Science.gov

Sample records for alternative design comparison

  1. Comparison of the FRM-II HEU design with an alternative LEU design

    SciTech Connect

    Mo, S.C.; Hanan, N.A.; Matos, J.E.

    1995-12-01

    The FRM-II reactor design of the Technical University of Munich has a compact core that utilizes fuel plates containing highly-enriched uranium (HEU, 93%). This paper presents an alternative core design utilizing low-enriched uranium (LEU, <20%) silicide fuel with 4.8 g/cm{sup 3} that provides nearly the same neutron flux for experiments as the HEU design, but has a less favorable fuel cycle economy. If an LEU fuel with a uranium density of 6.0 - 6.5 g/cm{sup 3} were developed, the alternative design would provide the same neutron flux and use the same number of cores per year as the HEU design. The results of this study show that there are attractive possibilities for using LEU fuel instead of HEU fuel in the FRM-II. Further optimization of the LEU design and near-term availability of LEU fuel with a uranium density greater than 4.8 g/cm{sup 3} would enhance the performance of the LEU core. The RERTR Program is ready to exchange information with the Technical University of Munich to resolve any differences that may exist and to identify design modifications that would optimize reactor performance utilizing LEU fuel.

  2. Thermal and electrical analysis of Mars Rover RTG, and performance comparison of alternative design options

    NASA Astrophysics Data System (ADS)

    Schock, Alfred; Or, Chuen T.; Skrabek, Emil A.

    This paper describes the thermal, thermoelectric, and electrical analysis of Radioisotope Thermoelectric Generators (RTGs) for powering the Mars Rover vehicle, which is a critical element of the unmanned Mars Rover and Sample Return mission (MRSR). It describes an analytical approach and computer code developed for this task, and examines the effect on the RTG's performance of different operating conditions. The paper also describes and analyzes a number of alternative RTG designs, to determine the effect of different power levels, different thermoelectric element designs, and different thermoelectric figures of merit on the RTG's specific power. The results presented show the RTG performance achievable with current technology, and the performance improvements that would be achievable with various technology developments. It provides a basis for selecting the optimum strategy for meeting the Mars Rover design goals with minimal programmatic risk and cost.

  3. Design of an Acoustic Array for Comparison with an Alternative Source Localization Method

    NASA Astrophysics Data System (ADS)

    Coombs, Deshawn; Lewalle, Jacques; Glauser, Mark; Wang, Guannan

    2013-11-01

    We report on the design, testing and construction of a conventional acoustic array, and document an alternate method of signal processing. The purpose of the new algorithm is to improve the spatial localization of acoustic sources. The reference results are obtained using the beamforming algorithm. The array design includes 60 microphones with a maximum aperture diameter of 39 inches. The arrays target frequency range is 500-5000 Hz. The new algorithm uses fewer microphones. We will show results with simulated signals and with jet noise experimental data. Details of the array calibration and representative data from measurements will be presented along with data post-processing procedures. Support from Syracuse University MAE department and LSAMP.

  4. Thermal and Electrical Analysis of MARS Rover RTG, and Performance Comparison of Alternative Design Options.

    SciTech Connect

    Schock, Alfred; Or, Chuen T; Skrabek, Emanuel A

    1989-09-29

    The paper describes the thermal, thermoelectric and electrical analysis of Radioisotope Thermoelectric Generators (RTGs) for powering the MARS Rover vehicle, which is a critical element of the unmanned Mars Rover and Sample Return mission (MRSR). The work described was part of an RTG design study conducted by Fairchild Space Company for the U.S. Department of Energy, in support of the Jet Propulsion Laboratory's MRSR Project.; A companion paper presented at this conference described a reference mission scenario, al illustrative Rover design and activity pattern on Mars, its power system requirements and environmental constraints, a design approach enabling RTG operation in the Martian atmosphere, and the design and the structural and mass analysis of a conservative baseline RTG employing safety-qualified heat source modules and reliability-proven thermoelectric converter elements.; The present paper presents a detailed description of the baseline RTG's thermal, thermoelectric, and electrical analysis. It examines the effect of different operating conditions (beginning versus end of mission, water-cooled versus radiation-cooled, summer day versus winter night) on the RTG's performance. Finally, the paper describes and analyzes a number of alternative RTG designs, to determine the effect of different power levels (250W versus 125W), different thermoelectric element designs (standard versus short unicouples versus multicouples) and different thermoelectric figures of merit (0.00058K(superscript -1) to 0.000140K (superscript -1) on the RTG's specific power.; The results presented show the RTG performance achievable with current technology, and the performance improvements that would be achievable with various technology developments. It provides a basis for selecting the optimum strategy for meeting the Mars Rover design goals with minimal programmatic risk and cost.; There is a duplicate copy and also a duplicate copy in the ESD files.

  5. Seal design alternatives study

    SciTech Connect

    Van Sambeek, L.L.

    1993-06-01

    This report presents the results from a study of various sealing alternatives for the WIPP sealing system. Overall, the sealing system has the purpose of reducing to the extent possible the potential for fluids (either gas or liquid) from entering or leaving the repository. The sealing system is divided into three subsystems: drift and panel seals within the repository horizon, shaft seals in each of the four shafts, and borehole seals. Alternatives to the baseline configuration for the WIPP seal system design included evaluating different geometries and schedules for seal component installations and the use of different materials for seal components. Order-of-magnitude costs for the various alternatives were prepared as part of the study. Firm recommendations are not presented, but the advantages and disadvantages of the alternatives are discussed. Technical information deficiencies are identified and studies are outlined which can provide required information.

  6. Evaluation and comparison of alternative designs for water/solid-waste processing systems for spacecraft

    NASA Technical Reports Server (NTRS)

    Spurlock, J. M.

    1975-01-01

    Promising candidate designs currently being considered for the management of spacecraft solid waste and waste-water materials were assessed. The candidate processes were: (1) the radioisotope thermal energy evaporation/incinerator process; (2) the dry incineration process; and (3) the wet oxidation process. The types of spacecraft waste materials that were included in the base-line computational input to the candidate systems were feces, urine residues, trash and waste-water concentrates. The performance characteristics and system requirements for each candidate process to handle this input and produce the specified acceptable output (i.e., potable water, a storable dry ash, and vapor phase products that can be handled by a spacecraft atmosphere control system) were estimated and compared. Recommendations are presented.

  7. State alternative route designations

    SciTech Connect

    Not Available

    1989-07-01

    Pursuant to the Hazardous Materials Transportation Act (HMTA), the Department of Transportation (DOT) has promulgated a comprehensive set of regulations regarding the highway transportation of high-level radioactive materials. These regulations, under HM-164 and HM-164A, establish interstate highways as the preferred routes for the transportation of radioactive materials within and through the states. The regulations also provide a methodology by which a state may select alternative routes. First,the state must establish a state routing agency,'' defined as an entity authorized to use the state legal process to impose routing requirements on carriers of radioactive material (49 CFR 171.8). Once identified, the state routing agency must select routes in accordance with Large Quantity Shipments of Radioactive Materials or an equivalent routing analysis. Adjoining states and localities should be consulted on the impact of proposed alternative routes as a prerequisite of final route selection. Lastly, the states must provide written notice of DOT of any alternative route designation before the routes are deemed effective.

  8. State alternative route designations

    SciTech Connect

    Not Available

    1989-07-01

    Pursuant to the Hazardous Materials Transportation Act (HMTA), the Department of Transportation (DOT) has promulgated a comprehensive set of regulations regarding the highway transportation of high-level radioactive materials. These regulations, under HM-164 and HM-164A, establish interstate highways as the preferred routes for the transportation of radioactive materials within and through the states. The regulations also provide a methodology by which a state may select alternative routes. First,the state must establish a ``state routing agency,`` defined as an entity authorized to use the state legal process to impose routing requirements on carriers of radioactive material (49 CFR 171.8). Once identified, the state routing agency must select routes in accordance with Large Quantity Shipments of Radioactive Materials or an equivalent routing analysis. Adjoining states and localities should be consulted on the impact of proposed alternative routes as a prerequisite of final route selection. Lastly, the states must provide written notice of DOT of any alternative route designation before the routes are deemed effective.

  9. Cost comparisons of alternative landfill final covers

    SciTech Connect

    Dwyer, S.F.

    1997-02-01

    A large-scale field demonstration comparing and contrasting final landfill cover designs has been constructed and is currently being monitored. Four alternative cover designs and two conventional designs (a RCRA Subtitle ``D`` Soil Cover and a RCRA Subtitle ``C`` Compacted Clay Cover) were constructed of uniform size, side-by-side. The demonstration is intended to evaluate the various cover designs based on their respective water balance performance, ease and reliability of construction, and cost. This paper provides an overview of the construction costs of each cover design.

  10. Alternative Natural Energy Sources in Building Design.

    ERIC Educational Resources Information Center

    Davis, Albert J.; Schubert, Robert P.

    This publication provides a discussion of various energy conserving building systems and design alternatives. The information presented here covers alternative space and water heating systems, and energy conserving building designs incorporating these systems and other energy conserving techniques. Besides water, wind, solar, and bio conversion…

  11. Alternate Propulsion Subsystem Concepts Tripropellant Comparison Study

    NASA Technical Reports Server (NTRS)

    Levack, Daniel

    1995-01-01

    A study was conducted under MSFC contract NAS8-39210 to compare tripropellant and bipropellant engine configurations for the SSTO mission. The objective was to produce an 'apples-to-apples' comparison to isolate the effects of design implementation, designing company, year of design, or technologies included from the basic tripropellant/bipropellant comparison. Consequently, identical technologies were included (e.g., jet pumps) and the same design groundrules and practices were used. Engine power cycles were examined as were turbomachinery/preburner arrangements for each cycle. The bipropellant approach and two tripropellant approaches were separately optimized in terms of operating parameters: exit pressures, mixture ratios, thrust splits, etc. This briefing presents the results of the study including engine weights for both tripropellant and bipropellant engines; dry vehicle weight performance for a range of engine chamber pressures; discusses the basis for the results; examines vehicle performance due to engine cycles and the margin characteristics of various cycles; and identifies technologies with significant payoffs for this application.

  12. Piled Embankment Design Comparison

    NASA Astrophysics Data System (ADS)

    Drusa, Marián; Kais, Ladislav; Vlček, Jozef; Mečár, Martin

    2015-05-01

    There are currently several national standards or regulations for the design of the piled embankment, providing suitable solutions for foundation of transport structure on soft, high compressible subsoil, [1]. The most widely used and the best-known standard is British Standard BS8006 [2], which was confronted with another analytical design methodologies (Ebgeo, CUR). Today's popularity and versatility of FEM numerical models brings many advantages, which analytical methods cannot achieved, but must be verified by proposed scaled physical model, which was currently being developed by Department of Geotechnics, University of Žilina.

  13. 49 CFR 229.209 - Alternative locomotive crashworthiness designs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Alternative locomotive crashworthiness designs... Locomotive Crashworthiness Design Requirements § 229.209 Alternative locomotive crashworthiness designs. (a... design standard. (b) Petitions for FRA approval of alternative locomotive crashworthiness designs....

  14. 49 CFR 229.209 - Alternative locomotive crashworthiness designs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Alternative locomotive crashworthiness designs... Locomotive Crashworthiness Design Requirements § 229.209 Alternative locomotive crashworthiness designs. (a... design standard. (b) Petitions for FRA approval of alternative locomotive crashworthiness designs....

  15. 49 CFR 229.209 - Alternative locomotive crashworthiness designs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Alternative locomotive crashworthiness designs... Locomotive Crashworthiness Design Requirements § 229.209 Alternative locomotive crashworthiness designs. (a... design standard. (b) Petitions for FRA approval of alternative locomotive crashworthiness designs....

  16. A comparison of alternative energy storage systems for automobiles

    NASA Astrophysics Data System (ADS)

    The performance potentials of primary batteries, fuel cells, and flywheel-transmission systems in comparison with secondary batteries as alternates to conventional internal combustion engine automobile power systems are discussed. A number of areas of research that are recommended for attention as part of a well-rounded investigation of alternatives are outlined.

  17. Optimizing Monitoring Designs under Alternative Objectives

    DOE PAGESBeta

    Gastelum, Jason A.; USA, Richland Washington; Porter, Ellen A.; USA, Richland Washington

    2014-12-31

    This paper describes an approach to identify monitoring designs that optimize detection of CO2 leakage from a carbon capture and sequestration (CCS) reservoir and compares the results generated under two alternative objective functions. The first objective function minimizes the expected time to first detection of CO2 leakage, the second more conservative objective function minimizes the maximum time to leakage detection across the set of realizations. The approach applies a simulated annealing algorithm that searches the solution space by iteratively mutating the incumbent monitoring design. The approach takes into account uncertainty by evaluating the performance of potential monitoring designs across amore » set of simulated leakage realizations. The approach relies on a flexible two-tiered signature to infer that CO2 leakage has occurred. This research is part of the National Risk Assessment Partnership, a U.S. Department of Energy (DOE) project tasked with conducting risk and uncertainty analysis in the areas of reservoir performance, natural leakage pathways, wellbore integrity, groundwater protection, monitoring, and systems level modeling.« less

  18. Optimizing Monitoring Designs under Alternative Objectives

    SciTech Connect

    Gastelum, Jason A.; USA, Richland Washington; Porter, Ellen A.; USA, Richland Washington

    2014-12-31

    This paper describes an approach to identify monitoring designs that optimize detection of CO2 leakage from a carbon capture and sequestration (CCS) reservoir and compares the results generated under two alternative objective functions. The first objective function minimizes the expected time to first detection of CO2 leakage, the second more conservative objective function minimizes the maximum time to leakage detection across the set of realizations. The approach applies a simulated annealing algorithm that searches the solution space by iteratively mutating the incumbent monitoring design. The approach takes into account uncertainty by evaluating the performance of potential monitoring designs across a set of simulated leakage realizations. The approach relies on a flexible two-tiered signature to infer that CO2 leakage has occurred. This research is part of the National Risk Assessment Partnership, a U.S. Department of Energy (DOE) project tasked with conducting risk and uncertainty analysis in the areas of reservoir performance, natural leakage pathways, wellbore integrity, groundwater protection, monitoring, and systems level modeling.

  19. An alternate end design for SSC dipoles

    SciTech Connect

    Peters, C.; Caspi, S.; Taylor, C.

    1989-02-01

    Experience in the SSC dipole program has shown that fabrication of cylindrical coil ends is difficult. Cable stiffness requires large forces to maintain the proper position of the conductors in the end during winding. After winding, the coil ends remain distorted nd significant motion of the need conductors is required to force the coil end into the molding cavity. Local mechanical stresses are high during this process and extra pieces of insulation are required to prevent turn-to-turn shorts from developing during the winding and molding steps. Prior to assembly the coil end is compressed in a mold cavity and injected with a filler material to correct surface irregularities and fill voids in the end. LBL has developed an alternate design which permits the conductors to be wound over the end using minimal force and technician coerosion. The conductors are placed on a conical surface where the largest diameter over the outer layer conductors is 10 cm. No coil end spaces or insulation pieces between turns are required. The conductor geometry was analytically optimized to meet SSC multipole requirements for the ends. The first 1-m dipole utilizing this end geometry has been constructed and successfully tested. Design and construction data are presented. Also model test results, including training and multipole measurements of the end are given. 1 ref., 12 figs., 3 tabs.

  20. Designing an Alternate Mission Operations Control Room

    NASA Technical Reports Server (NTRS)

    Montgomery, Patty; Reeves, A. Scott

    2014-01-01

    The Huntsville Operations Support Center (HOSC) is a multi-project facility that is responsible for 24x7 real-time International Space Station (ISS) payload operations management, integration, and control and has the capability to support small satellite projects and will provide real-time support for SLS launches. The HOSC is a service-oriented/ highly available operations center for ISS payloads-directly supporting science teams across the world responsible for the payloads. The HOSC is required to endure an annual 2-day power outage event for facility preventive maintenance and safety inspection of the core electro-mechanical systems. While complete system shut-downs are against the grain of a highly available sub-system, the entire facility must be powered down for a weekend for environmental and safety purposes. The consequence of this ground system outage is far reaching: any science performed on ISS during this outage weekend is lost. Engineering efforts were focused to maximize the ISS investment by engineering a suitable solution capable of continuing HOSC services while supporting safety requirements. The HOSC Power Outage Contingency (HPOC) System is a physically diversified compliment of systems capable of providing identified real-time services for the duration of a planned power outage condition from an alternate control room. HPOC was designed to maintain ISS payload operations for approximately three continuous days during planned HOSC power outages and support a local Payload Operations Team, International Partners, as well as remote users from the alternate control room located in another building.

  1. 49 CFR 229.209 - Alternative locomotive crashworthiness designs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Alternative locomotive crashworthiness designs... Locomotive Crashworthiness Design Requirements § 229.209 Alternative locomotive crashworthiness designs. (a... locomotive crashworthiness designs which are not consistent with any FRA-approved locomotive...

  2. 40 CFR 72.22 - Alternate designated representative.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Alternate designated representative. 72.22 Section 72.22 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Designated Representative § 72.22 Alternate designated representative. (a) The certificate of representation...

  3. 40 CFR 60.4111 - Alternate Hg designated representative.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 6 2010-07-01 2010-07-01 false Alternate Hg designated representative... Times for Coal-Fired Electric Steam Generating Units Hg Designated Representative for Hg Budget Sources § 60.4111 Alternate Hg designated representative. (a) A certificate of representation under §...

  4. 46 CFR 177.340 - Alternate design considerations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Alternate design considerations. 177.340 Section 177.340... TONS) CONSTRUCTION AND ARRANGEMENT Hull Structure § 177.340 Alternate design considerations. When the structure of vessel is of novel design, unusual form, or special materials, which cannot be reviewed...

  5. 46 CFR 116.340 - Alternate design considerations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Alternate design considerations. 116.340 Section 116.340... ARRANGEMENT Hull Structure § 116.340 Alternate design considerations. The Commanding Officer, Marine Safety Center, may approve the structure of a vessel of novel design, unusual form, or special materials,...

  6. 46 CFR 177.340 - Alternate design considerations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Alternate design considerations. 177.340 Section 177.340... TONS) CONSTRUCTION AND ARRANGEMENT Hull Structure § 177.340 Alternate design considerations. When the structure of vessel is of novel design, unusual form, or special materials, which cannot be reviewed...

  7. 46 CFR 116.340 - Alternate design considerations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Alternate design considerations. 116.340 Section 116.340... ARRANGEMENT Hull Structure § 116.340 Alternate design considerations. The Commanding Officer, Marine Safety Center, may approve the structure of a vessel of novel design, unusual form, or special materials,...

  8. 46 CFR 177.340 - Alternate design considerations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Alternate design considerations. 177.340 Section 177.340... TONS) CONSTRUCTION AND ARRANGEMENT Hull Structure § 177.340 Alternate design considerations. When the structure of vessel is of novel design, unusual form, or special materials, which cannot be reviewed...

  9. 46 CFR 116.340 - Alternate design considerations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Alternate design considerations. 116.340 Section 116.340... ARRANGEMENT Hull Structure § 116.340 Alternate design considerations. The Commanding Officer, Marine Safety Center, may approve the structure of a vessel of novel design, unusual form, or special materials,...

  10. 46 CFR 116.340 - Alternate design considerations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Alternate design considerations. 116.340 Section 116.340... ARRANGEMENT Hull Structure § 116.340 Alternate design considerations. The Commanding Officer, Marine Safety Center, may approve the structure of a vessel of novel design, unusual form, or special materials,...

  11. 46 CFR 177.340 - Alternate design considerations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Alternate design considerations. 177.340 Section 177.340... TONS) CONSTRUCTION AND ARRANGEMENT Hull Structure § 177.340 Alternate design considerations. When the structure of vessel is of novel design, unusual form, or special materials, which cannot be reviewed...

  12. 77 FR 30047 - Petition for Alternative Locomotive Crashworthiness Design

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-21

    ... Federal Railroad Administration Petition for Alternative Locomotive Crashworthiness Design In accordance... design for an electric locomotive, Model ACS-64, built by Siemens Industry, Inc. This request is made in...-0036. The alternative design incorporates crash energy management features, detailed in the...

  13. 40 CFR 97.111 - Alternate CAIR designated representative.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 21 2014-07-01 2014-07-01 false Alternate CAIR designated representative. 97.111 Section 97.111 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... Designated Representative for CAIR NOX Sources § 97.111 Alternate CAIR designated representative. (a)...

  14. 40 CFR 97.111 - Alternate CAIR designated representative.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 22 2013-07-01 2013-07-01 false Alternate CAIR designated representative. 97.111 Section 97.111 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... Designated Representative for CAIR NOX Sources § 97.111 Alternate CAIR designated representative. (a)...

  15. Alternative designs for nanocrystalline silicon solar cells

    NASA Astrophysics Data System (ADS)

    Madhavan, Atul

    Nanocrystalline silicon is an attractive material for solar cells. It has very small grains, about 20 nm, and yet its electronic properties are very similar to those of crystalline silicon. The material exhibits smaller mobilities than crystalline Silicon, but the minority carrier lifetimes are reasonable. It is known that the properties of the material depend critically upon deposition parameters, in particular, the degree of grain boundary passivation achieved during growth and grain size. Previous work has shown that as the material grows, the grains tend to agglomerate into a cluster, and the development of this cluster leads to poorer electronic properties. The traditional method for overcoming such clustering has been to change the hydrogen to silane dilution ratio as the material grows, keeping the material near its crystalline to amorphous transition zone. However, this method is dependent upon the precise growth chemistry and is not suitable for mass production. In this project, we develop a new device design, a superlattice comprising alternating layers of amorphous and nanocrystalline silicon, which allows one to precisely control the agglomeration of grains without having to resort to hydrogen profiling techniques. We study structural properties such as grain size and the degree of crystallnity, and electronic properties such as carrier diffusion lengths and defect densities. We show that an appropriate design of the superlattice allows one to minimize defect densities and maximize carrier diffusion lengths. We also study how to reduce series resistance in solar cells, and show that an appropriate combination of superlattice and contacts can lead to devices with high fill factors and good solar cell efficiencies. We also report on a new discovery, namely that the optical absorption itself depends critically upon grain size. Larger grain sizes, up to 50 nm, lead to increased optical absorption, a totally unexpected and very useful discovery for devices

  16. Alternative methods for the design of jet engine control systems

    NASA Technical Reports Server (NTRS)

    Sain, M. K.; Leake, R. J.; Basso, R.; Gejji, R.; Maloney, A.; Seshadri, V.

    1976-01-01

    Various alternatives to linear quadratic design methods for jet engine control systems are discussed. The main alternatives are classified into two broad categories: nonlinear global mathematical programming methods and linear local multivariable frequency domain methods. Specific studies within these categories include model reduction, the eigenvalue locus method, the inverse Nyquist method, polynomial design, dynamic programming, and conjugate gradient approaches.

  17. 40 CFR 96.111 - Alternate CAIR designated representative.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 22 2013-07-01 2013-07-01 false Alternate CAIR designated representative. 96.111 Section 96.111 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... IMPLEMENTATION PLANS CAIR Designated Representative for CAIR NOX Sources § 96.111 Alternate CAIR...

  18. 40 CFR 96.111 - Alternate CAIR designated representative.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 21 2014-07-01 2014-07-01 false Alternate CAIR designated representative. 96.111 Section 96.111 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... IMPLEMENTATION PLANS CAIR Designated Representative for CAIR NOX Sources § 96.111 Alternate CAIR...

  19. Case studies in alternative landfill design

    SciTech Connect

    Barbagallo, J.C.; Druback, G.W.

    1995-12-31

    In the past, landfills or {open_quotes}dumps{close_quotes} were not highly regulated and typically did not require a detailed engineering design. However, landfills are no longer just holes in the ground, and landfill closures entail more than just spreading some dirt on top of piles of garbage. Today landfill design is a highly regulated, complex design effort that integrates soils and geosynthetics into systems aimed at providing long-term protection for the environment and surrounding communities. Integrating these complex design systems into the available landscape and exising landfill configuration often requires the designer go beyond the {open_quotes}typical{close_quotes} landfill and landfill closure design to satisfy regulations and provide cost-effective solutions.

  20. Digital Hardware Design Teaching: An Alternative Approach

    ERIC Educational Resources Information Center

    Benkrid, Khaled; Clayton, Thomas

    2012-01-01

    This article presents the design and implementation of a complete review of undergraduate digital hardware design teaching in the School of Engineering at the University of Edinburgh. Four guiding principles have been used in this exercise: learning-outcome driven teaching, deep learning, affordability, and flexibility. This has identified…

  1. Designing oligo libraries taking alternative splicing into account

    NASA Astrophysics Data System (ADS)

    Shoshan, Avi; Grebinskiy, Vladimir; Magen, Avner; Scolnicov, Ariel; Fink, Eyal; Lehavi, David; Wasserman, Alon

    2001-06-01

    We have designed sequences for DNA microarrays and oligo libraries, taking alternative splicing into account. Alternative splicing is a common phenomenon, occurring in more than 25% of the human genes. In many cases, different splice variants have different functions, are expressed in different tissues or may indicate different stages of disease. When designing sequences for DNA microarrays or oligo libraries, it is very important to take into account the sequence information of all the mRNA transcripts. Therefore, when a gene has more than one transcript (as a result of alternative splicing, alternative promoter sites or alternative poly-adenylation sites), it is very important to take all of them into account in the design. We have used the LEADS transcriptome prediction system to cluster and assemble the human sequences in GenBank and design optimal oligonucleotides for all the human genes with a known mRNA sequence based on the LEADS predictions.

  2. Alternative clinical trial design in neurocritical care.

    PubMed

    Lazaridis, Christos; Maas, Andrew I R; Souter, Michael J; Martin, Renee H; Chesnut, Randal M; DeSantis, Stacia M; Sung, Gene; Leroux, Peter D; Suarez, Jose I

    2015-06-01

    Neurocritical care involves the care of highly complex patients with combinations of physiologic derangements in the brain and in extracranial organs. The level of evidence underpinning treatment recommendations remains low due to a multitude of reasons including an incomplete understanding of the involved physiology; lack of good quality, prospective, standardized data; and the limited success of conventional randomized controlled trials. Comparative effectiveness research can provide alternative perspectives and methods to enhance knowledge and evidence within the field of neurocritical care; these include large international collaborations for generation and maintenance of high quality data, statistical methods that incorporate heterogeneity and individualize outcome prediction, and finally advanced bioinformatics that integrate large amounts of variable-source data into patient-specific phenotypes and trajectories. PMID:25894451

  3. Alternative aperture stop position designs for SIRTF

    NASA Technical Reports Server (NTRS)

    Davis, Paul K.; Dinger, Ann S.

    1990-01-01

    Three designs of the Space Infrared Telescope Facility (SIRTF) for a 100,000 high earth orbit are considered with particular attention given to the evaluation of the aperture stop position. The choice of aperture stop position will be based on stray light considerations which are being studied concurrently. It is noted that there are advantages in cost, mass, and astronomical aperture to placing the aperture stop at or near the primary mirror, if the stray light circumstances allow.

  4. 36. DETAIL, ALTERNATE DESIGN USING THROUGH ARCH SPANS Pencil drawing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    36. DETAIL, ALTERNATE DESIGN USING THROUGH ARCH SPANS Pencil drawing by project architect Alfred Eichler, ca. 1934. - Sacramento River Bridge, Spanning Sacramento River at California State Highway 275, Sacramento, Sacramento County, CA

  5. Insights Gained from Testing Alternate Cell Designs

    SciTech Connect

    J. E. O'Brien; C. M. Stoots; J. S. Herring; G. K. Housley; M. S. Sohal; D. G. Milobar; Thomas Cable

    2009-09-01

    The Idaho National Laboratory (INL) has been researching the application of solid-oxide electrolysis cell for large-scale hydrogen production from steam over a temperature range of 800 to 900ºC. The INL has been testing various solid oxide cell designs to characterize their electrolytic performance operating in the electrolysis mode for hydrogen production. Some results presented in this report were obtained from cells, initially developed by the Forschungszentrum Jülich and now manufactured by the French ceramics firm St. Gobain. These cells have an active area of 16 cm2 per cell. They were initially developed as fuel cells, but are being tested as electrolytic cells in the INL test stands. The electrolysis cells are electrode-supported, with ~10 µm thick yttria-stabilized zirconia (YSZ) electrolytes, ~1400 µm thick nickel-YSZ steam-hydrogen electrodes, and manganite (LSM) air-oxygen electrodes. The experiments were performed over a range of steam inlet mole fractions (0.1 to 0.6), gas flow rates, and current densities (0 to 0.6 A/cm2). Steam consumption rates associated with electrolysis were measured directly using inlet and outlet dewpoint instrumentation. On a molar basis, the steam consumption rate is equal to the hydrogen production rate. Cell performance was evaluated by performing DC potential sweeps at 800, 850, and 900°C. The voltage-current characteristics are presented, along with values of area-specific resistance as a function of current density. Long-term cell performance is also assessed to evaluate cell degradation. Details of the custom single-cell test apparatus developed for these experiments are also presented. NASA, in conjunction with the University of Toledo, has developed another fuel cell concept with the goals of reduced weight and high power density. The NASA cell is structurally symmetrical, with both electrodes supporting the thin electrolyte and containing micro-channels for gas diffusion. This configuration is called a bi

  6. Brayton heat exchanger unit development program (alternate design)

    NASA Technical Reports Server (NTRS)

    Duncan, J. D.; Gibson, J. C.; Graves, R. F.; Morse, C. J.; Richard, C. E.

    1973-01-01

    A Brayton Heat Exchanger Unit Alternate Design (BHXU-Alternate) consisting of a recuperator, a heat sink heat exchanger, and a gas ducting system, was designed and fabricated. The design was formulated to provide a high performance unit suitable for use in a long-life Brayton-cycle powerplant. Emphasis was on double containment against external leakage and leakage of the organic coolant into the gas stream. A parametric analysis and design study was performed to establish the optimum component configurations to achieve low weight and size and high reliability, while meeting the requirements of high effectiveness and low pressure drop. Layout studies and detailed mechanical and structural design were performed to obtain a flight-type packaging arrangement, including the close-coupled integration of the BHXU-Alternate with the Brayton Rotating Unit (BRU).

  7. ENVIRONMENTAL COMPARISON METRICS FOR LIFE CYCLE IMPACT ASSESSMENT AND PROCESS DESIGN

    EPA Science Inventory

    Metrics (potentials, potency factors, equivalency factors or characterization factors) are available to support the environmental comparison of alternatives in application domains like proces design and product life-cycle assessment (LCA). These metrics typically provide relative...

  8. 40 CFR 72.22 - Alternate designated representative.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... the term “designated representative” is used under the Acid Rain Program, the term shall be construed...), whenever the term “alternate designated representative” is used under the Acid Rain Program, the term shall...” is used under the Acid Rain Program, the term shall be construed to include either of the...

  9. 40 CFR 72.22 - Alternate designated representative.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... the term “designated representative” is used under the Acid Rain Program, the term shall be construed...), whenever the term “alternate designated representative” is used under the Acid Rain Program, the term shall...” is used under the Acid Rain Program, the term shall be construed to include either of the...

  10. 40 CFR 72.22 - Alternate designated representative.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the term “designated representative” is used under the Acid Rain Program, the term shall be construed...), whenever the term “alternate designated representative” is used under the Acid Rain Program, the term shall... used under the Acid Rain Program, the term shall be construed to include either of the...

  11. 40 CFR 72.22 - Alternate designated representative.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the term “designated representative” is used under the Acid Rain Program, the term shall be construed...), whenever the term “alternate designated representative” is used under the Acid Rain Program, the term shall...” is used under the Acid Rain Program, the term shall be construed to include either of the...

  12. 46 CFR 177.340 - Alternate design considerations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... TONS) CONSTRUCTION AND ARRANGEMENT Hull Structure § 177.340 Alternate design considerations. When the structure of vessel is of novel design, unusual form, or special materials, which cannot be reviewed or approved in accordance with §§ 177.300, 177.310 or 177.315, the structure may be approved by the...

  13. 46 CFR 116.340 - Alternate design considerations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ARRANGEMENT Hull Structure § 116.340 Alternate design considerations. The Commanding Officer, Marine Safety Center, may approve the structure of a vessel of novel design, unusual form, or special materials, which... principles that the vessel structure provides adequate safety and strength. An owner seeking approval of...

  14. Nonrandom Assignment in ANCOVA: The Alternate Ranks Design

    ERIC Educational Resources Information Center

    Dalton, Starrett; Overall, John E.

    1977-01-01

    A specific form of nonrandom assignment to treatment groups, the "alternate ranks" design, was investigated. This design eliminates the possibility of a correlation between the covariate and the treatment, and rules out experimenter bias in assignment of subjects to groups. (Editor)

  15. Subsurface barrier design alternatives for confinement and controlled advection flow

    SciTech Connect

    Phillips, S.J.; Stewart, W.E.; Alexander, R.G.; Cantrell, K.J.; McLaughlin, T.J.

    1994-02-01

    Various technologies and designs are being considered to serve as subsurface barriers to confine or control contaminant migration from underground waste storage or disposal structures containing radioactive and hazardous wastes. Alternatives including direct-coupled flood and controlled advection designs are described as preconceptual examples. Prototype geotechnical equipment for testing and demonstration of these alternative designs tested at the Hanford Geotechnical Development and Test Facility and the Hanford Small-Tube Lysimeter Facility include mobile high-pressure injectors and pumps, mobile transport and pumping units, vibratory and impact pile drivers, and mobile batching systems. Preliminary laboratory testing of barrier materials and additive sequestering agents have been completed and are described.

  16. 29 CFR 2703.2 - Designated agency ethics official and alternate designated agency ethics official.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 9 2011-07-01 2011-07-01 false Designated agency ethics official and alternate designated agency ethics official. 2703.2 Section 2703.2 Labor Regulations Relating to Labor (Continued) FEDERAL... agency ethics official and alternate designated agency ethics official. The Chairman shall appoint...

  17. 29 CFR 2703.2 - Designated agency ethics official and alternate designated agency ethics official.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 9 2012-07-01 2012-07-01 false Designated agency ethics official and alternate designated agency ethics official. 2703.2 Section 2703.2 Labor Regulations Relating to Labor (Continued) FEDERAL... agency ethics official and alternate designated agency ethics official. The Chairman shall appoint...

  18. 29 CFR 2703.2 - Designated agency ethics official and alternate designated agency ethics official.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Designated agency ethics official and alternate designated agency ethics official. 2703.2 Section 2703.2 Labor Regulations Relating to Labor (Continued) FEDERAL... agency ethics official and alternate designated agency ethics official. The Chairman shall appoint...

  19. 29 CFR 2703.2 - Designated agency ethics official and alternate designated agency ethics official.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 9 2013-07-01 2013-07-01 false Designated agency ethics official and alternate designated agency ethics official. 2703.2 Section 2703.2 Labor Regulations Relating to Labor (Continued) FEDERAL... agency ethics official and alternate designated agency ethics official. The Chairman shall appoint...

  20. 29 CFR 2703.2 - Designated agency ethics official and alternate designated agency ethics official.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 9 2014-07-01 2014-07-01 false Designated agency ethics official and alternate designated agency ethics official. 2703.2 Section 2703.2 Labor Regulations Relating to Labor (Continued) FEDERAL... agency ethics official and alternate designated agency ethics official. The Chairman shall appoint...

  1. The cost of ethanol production from lignocellulosic biomass -- A comparison of selected alternative processes. Final report

    SciTech Connect

    Grethlein, H.E.; Dill, T.

    1993-04-30

    The purpose of this report is to compare the cost of selected alternative processes for the conversion of lignocellulosic biomass to ethanol. In turn, this information will be used by the ARS/USDA to guide the management of research and development programs in biomass conversion. The report will identify where the cost leverages are for the selected alternatives and what performance parameters need to be achieved to improve the economics. The process alternatives considered here are not exhaustive, but are selected on the basis of having a reasonable potential in improving the economics of producing ethanol from biomass. When other alternatives come under consideration, they should be evaluated by the same methodology used in this report to give fair comparisons of opportunities. A generic plant design is developed for an annual production of 25 million gallons of anhydrous ethanol using corn stover as the model substrate at $30/dry ton. Standard chemical engineering techniques are used to give first order estimates of the capital and operating costs. Following the format of the corn to ethanol plant, there are nine sections to the plant; feed preparation, pretreatment, hydrolysis, fermentation, distillation and dehydration, stillage evaporation, storage and denaturation, utilities, and enzyme production. There are three pretreatment alternatives considered: the AFEX process, the modified AFEX process (which is abbreviated as MAFEX), and the STAKETECH process. These all use enzymatic hydrolysis and so an enzyme production section is included in the plant. The STAKETECH is the only commercially available process among the alternative processes.

  2. Coal slurry transportation alternatives: Conceptual design and economics: Final report

    SciTech Connect

    Mann, C.E.; Manning, S.H.

    1987-07-01

    The Coal Slurry Transportation Alternatives study provides utilities with a decisionmaking tool and necessary cost data to facilitate a systematic and rigorous comparison of slurry, rail, and barge transportation from the mine to the busbar for coal deliveries to both existing and new power plants. Volume 3 summarizes the methodology and results of examining operating and cost differences between slurry and run-of-mine coal. Two objectives of the study are to document the engineering costs and assumptions of the coal slurry pipeline system and to provide comparative estimates of costs and performance for power generation from slurry pipeline and run-of-mine coal. The results indicate that an increase in fuel moisture causes a decrease in boiler efficiency; that is, higher fuel burn rates and higher gas flows. For new plants, major equipment must be sized to accommodate higher fuel, ash, and flue gas flow rates associated with coal slurry. Other impacts include higher auxiliary power requirements, increased scrubber additive requirements, and potential increases in plant maintenance. For existing plants, a more serious concern may be the capability of current fuel transport systems to properly dry and transport the fuel. Flue gas flow rates for slurry should be within the design margins of run-of-mine, but where flue gas flow rates are increased, downstream FGD and particulate removal equipment may be impacted. Of the total levelized busbar costs for new plants, approximately 40 percent of differential costs are associated with capital, with the remaining 60 percent associated with consumables. For existing plants, replacement power costs due to limitations in fuel drying and conveyance may be up to 20 percent of the total generation cost. 40 figs., 62 tabs.

  3. Evaluation of HiPHES convective reformer design alternatives

    SciTech Connect

    Not Available

    1991-08-01

    Phase I Stone Webster presented three potential design configurations for a ceramic-tubed steam-methane reformer. These were the Tube-Within-a-Tube (TWIT) design, the Once-Through design, and the Monolith design. Although the TWIT design configuration appeared to be the most viable, the inclusion of a more detailed examination of design alternatives for the HiPHES reformer was deemed appropriate for the Phase II program. Of particular concern was the length of the ceramic tubes required for the TWIT design. To assist in this evaluation, Stone Webster established a Development Team consisting of specialists in the areas of heat transfer, ceramic materials, exchanger design, vessel design, and potential users. Stone Webster reviewed the critical areas of concern for a ceramic convective reformer, evaluated competing design configurations, and presented the results to the Development Team. This report presents Stone Webster's evaluations and the comments and recommendations of the Development Team. This effort comprised the majority of Task 1 of Phase II of Stone Webster's HiPHES project. The design review was executed in parallel with the material coupon screening tests at BP America. The goal of both tasks was to confirm the materials selection and reformer design configuration so that the conditions for the tube and joint tests to be conducted at Oak Ridge National Laboratory (ORNL) could be specified. The ORNL tests are intended to evaluate the reformer design configuration and materials of construction used for the reformer design in Phase II, and to be used in the demonstration unit in Phase III. The Task 1 (Evaluation of Alternative Reformer Designs) effort has identified a preferred design configuration for the proposed ceramic reformer. Additional engineering and material evaluation work is necessary before an operating prototype can be designed.

  4. Comparison of alternative cogeneration power systems for three industrial sites

    SciTech Connect

    Harper, A.D.

    1983-01-01

    Three alternative on-site cogeneration power systems were evaluated against technical and economic criteria for three industrial sites. Technical factors included plant sizing to meet process thermal loads, fuel utilization, power output, siting consideration, fuel savings, etc. Economic factors included capital cost, return on equity, and ownership/financing options among others. Each cogeneration plant was evaluated by comparison with the current separate generation scheme. The technologies considered were conventional coal-fired, steam topping cycles; coal-fired, atmospheric fluidized bed/closed-cycle gas turbines; and coal-fired, atmospheric fluidized bed/open cycle gas turbines. These approaches were optimized for three sites: an agricultural chemical plant, a brewery, and a kraft paper mill. The results showed that the closed cycle gas turbines yielded the best economics, primarily due to a lower initial cost. The open cycle gas turbine, when combined with a steam bottoming cycle, resulted in larger power outputs than would be realized in the closed cycle or steam turbine cases. None of the plants studied matched the plant electrical load while following the thermal load.

  5. An alternative tensiometer design for deep vadose zone monitoring

    NASA Astrophysics Data System (ADS)

    Moradi, A. B.; Kandelous, M. M.; Hopmans, J. W.

    2015-12-01

    The conventional tensiometer is among the most accurate devices for soil water matric potential measurements, as well as for estimations of soil water flux from soil water potential gradients. Uncertainties associated with conventional tensiometers such as caused by ambient temperature effects and the draining of the tensiometer tube, as well as their limitation for deep soil monitoring has prevented their widespread use for vadose zone monitoring, despite their superior accuracy, in general. We introduce an alternative tensiometer design that offers the accuracy of the conventional tensiometer, while minimizing afore-mentioned uncertainties and limitations. The proposed alternative tensiometer largely eliminates temperature-induced diurnal fluctuations and uncertainties associated with the draining of the tensiometer tube, and removes the limitation in installation depth. In addition, the manufacturing costs of this alternative tensiometer design is close to that of the conventional tensiometer, while it is especially suited for monitoring of soil water potential gradients as required for soil water flux measurements.

  6. 34. ALTERNATE DESIGN USING BATTERED AND UNSHEATHED LIFT TOWERS, WITH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    34. ALTERNATE DESIGN USING BATTERED AND UNSHEATHED LIFT TOWERS, WITH DEEPENED TRUSS ON LIFT SPAN. Pen-and-ink drawing by project architect Alfred Eichler, 1934. - Sacramento River Bridge, Spanning Sacramento River at California State Highway 275, Sacramento, Sacramento County, CA

  7. 37. ALTERNATE DESIGN, SIMILAR TO THAT ULTIMATELY SELECTED, BUT USING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    37. ALTERNATE DESIGN, SIMILAR TO THAT ULTIMATELY SELECTED, BUT USING STEPPED TOWERS, AND WITH PYLONS CAPPED BY LANTERNS Pen-and-ink drawing by project architect Alfred Eichler, ca. 1934. - Sacramento River Bridge, Spanning Sacramento River at California State Highway 275, Sacramento, Sacramento County, CA

  8. 35. ALTERNATE DESIGN USING THROUGH ARCH SPANS, WITH ARCH REPEATED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    35. ALTERNATE DESIGN USING THROUGH ARCH SPANS, WITH ARCH REPEATED BETWEEN TOWER LEGS, AND ASHLAR MASONRY WALLS AND PYLONS Pen-and-ink drawing by project architect Alfred Eichler, 1934. - Sacramento River Bridge, Spanning Sacramento River at California State Highway 275, Sacramento, Sacramento County, CA

  9. Expert System Approach For Generating And Evaluating Engine Design Alternatives

    NASA Astrophysics Data System (ADS)

    Shen, Stewart N. T.; Chew, Meng-Sang; Issa, Ghassan F.

    1989-03-01

    Artificial intelligence is becoming an increasingly important subject of study for computer scientists, engineering designers, as well as professionals in other fields. Even though AI technology is a relatively new discipline, many of its concepts have already found practical applications. Expert systems, in particular, have made significant contributions to technologies in such fields as business, medicine, engineering design, chemistry, and particle physics. This paper describes an expert system developed to aid the mechanical designer with the preliminary design of variable-stroke internal-combustion engines. The expert system accomplished its task by generating and evaluating a large number of design alternatives represented in the form of graphs. Through the application of structural and design rules directly to the graphs, optimal and near optimal preliminary design configurations of engines are deduced.

  10. Dairy cow preference and usage of an alternative freestall design.

    PubMed

    Abade, C C; Fregonesi, J A; von Keyserlingk, M A G; Weary, D M

    2015-02-01

    Freestall housing for dairy cows was created to reduce the amount of bedding and labor needed to keep stalls clean. However, some aspects of stall design may restrict stall usage by cows. The aim of this study was to assess dairy cow preference and usage of a conventional stall (with a neck rail and metal stall dividers) and an alternative stall design with no neck rail or stall dividers other than a wooden board protruding slightly (8cm) above the lying surface. In the no-choice phase of the study, 48 cows were randomly assigned to 8 groups (of 6 cows each); groups were alternately allocated to the 2 treatments. Each group was observed for 7 d on one treatment and then switched to the alternate treatment for 7 d. For the choice phase (also 7 d), groups in adjacent pens were merged (to form 4 groups, each with 12 cows) and cows had free access to both treatments within the merged pen. In the no-choice phase, cows spent more time standing with 4 hooves in the alternative versus conventional freestall (0.60±0.06 vs. 0.05±0.06h/d), but stall designs had no effect on time spent lying down (13.2±0.4 vs. 12.9±0.4h/d). In the choice phase, cows spent more time lying down in the conventional freestall (9.4±0.8 vs. 4.1±0.8h/d) and more time standing with all 4 hooves in the alternative stall (0.24±0.03 vs. 0.02±0.03h/d). These results illustrate how different stall design features can affect different types of stall use; the more open design facilitated standing fully in the stall, but the protruding partitions likely made the stall less suitable for lying. PMID:25497827

  11. An alternative LEU design for the FRM-II

    SciTech Connect

    Hanan, N.A.; Mo, S.C.; Smith, R.S.; Matos, J.E.

    1997-02-01

    The Alternative LEU Design for the FRM-II proposed by the RERTR Program at Argonne National Laboratory (ANL) has a compact core consisting of a single fuel element that uses LEU silicide fuel with a uranium density of 4.5 g/cm[sup 3] and has a power level of 32 MW. Both the HEU design by the Technical University of Munich (TUM) and the alternative LEU design by ANL have the same fuel lifetime (50 days) and the same neutron flux performance (8 x 10[sup 14] n/cm[sup 2]/s in the reflector). LEU silicide fuel with 4.5 g/cm[sup 3] has been thoroughly tested and is fully-qualified, licensable, and available now for use in a high flux reactor such as the FRM-II. Computer models for the HEU and LEU designs have been exchanged between TUM and ANL and discrepancies have been resolved. The following issues are addressed: qualification of HEU and LEU silicide fuels, stability of the fuel plates, gamma heating in the heavy water reflector, a hypothetical accident involving the configuration of the reflector, a loss of primary coolant flow transient due to an interrupted power supply, the radiological consequences of larger fission product and plutonium inventories in the LEU core, and cost and schedule. Calculations were also done to address the possibility that new high density LEU fuels could be developed that would allow conversion of the TUM HEU design to LEU fuel. Based on the excellent results for the Alternative LEU Design that were obtained in these analyses, the RERTR Program concludes that all of the major technical issues regarding use of LEU fuel instead of HEU fuel in the FRM-II have been successfully resolved and that it is definitely feasible to use LEU fuel in the FRM-II without compromising the safety or performance of the facility.

  12. 40 CFR 97.312 - Changing CAIR designated representative and alternate CAIR designated representative; changes in...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... for CAIR NOX Ozone Season Sources § 97.312 Changing CAIR designated representative and alternate CAIR... superseding complete certificate of representation under § 97.313. Notwithstanding any such change, all... Season source and the CAIR NOX Ozone Season units at the source. (b) Changing alternate CAIR...

  13. 40 CFR 97.312 - Changing CAIR designated representative and alternate CAIR designated representative; changes in...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... for CAIR NOX Ozone Season Sources § 97.312 Changing CAIR designated representative and alternate CAIR... superseding complete certificate of representation under § 97.313. Notwithstanding any such change, all... Season source and the CAIR NOX Ozone Season units at the source. (b) Changing alternate CAIR...

  14. 40 CFR 97.312 - Changing CAIR designated representative and alternate CAIR designated representative; changes in...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... for CAIR NOX Ozone Season Sources § 97.312 Changing CAIR designated representative and alternate CAIR... superseding complete certificate of representation under § 97.313. Notwithstanding any such change, all... Season source and the CAIR NOX Ozone Season units at the source. (b) Changing alternate CAIR...

  15. 40 CFR 97.312 - Changing CAIR designated representative and alternate CAIR designated representative; changes in...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... for CAIR NOX Ozone Season Sources § 97.312 Changing CAIR designated representative and alternate CAIR... superseding complete certificate of representation under § 97.313. Notwithstanding any such change, all... Season source and the CAIR NOX Ozone Season units at the source. (b) Changing alternate CAIR...

  16. 40 CFR 97.312 - Changing CAIR designated representative and alternate CAIR designated representative; changes in...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... for CAIR NOX Ozone Season Sources § 97.312 Changing CAIR designated representative and alternate CAIR... superseding complete certificate of representation under § 97.313. Notwithstanding any such change, all... Season source and the CAIR NOX Ozone Season units at the source. (b) Changing alternate CAIR...

  17. 40 CFR 97.615 - Changing designated representative and alternate designated representative; changes in owners and...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (CONTINUED) FEDERAL NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS TR SO2 Group 1 Trading... new designated representative and the owners and operators of the TR SO2 Group 1 source and the TR SO2... alternate designated representative, the designated representative, and the owners and operators of the...

  18. 40 CFR 97.615 - Changing designated representative and alternate designated representative; changes in owners and...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (CONTINUED) FEDERAL NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS TR SO2 Group 1 Trading... new designated representative and the owners and operators of the TR SO2 Group 1 source and the TR SO2... alternate designated representative, the designated representative, and the owners and operators of the...

  19. 40 CFR 97.415 - Changing designated representative and alternate designated representative; changes in owners and...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (CONTINUED) FEDERAL NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS TR NOX Annual Trading... new designated representative and the owners and operators of the TR NOX Annual source and the TR NOX... alternate designated representative, the designated representative, and the owners and operators of the...

  20. 40 CFR 97.415 - Changing designated representative and alternate designated representative; changes in owners and...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (CONTINUED) FEDERAL NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS TR NOX Annual Trading... new designated representative and the owners and operators of the TR NOX Annual source and the TR NOX... alternate designated representative, the designated representative, and the owners and operators of the...

  1. 40 CFR 97.615 - Changing designated representative and alternate designated representative; changes in owners and...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (CONTINUED) FEDERAL NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS TR SO2 Group 1 Trading... new designated representative and the owners and operators of the TR SO2 Group 1 source and the TR SO2... alternate designated representative, the designated representative, and the owners and operators of the...

  2. 40 CFR 97.415 - Changing designated representative and alternate designated representative; changes in owners and...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (CONTINUED) FEDERAL NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS TR NOX Annual Trading... new designated representative and the owners and operators of the TR NOX Annual source and the TR NOX... alternate designated representative, the designated representative, and the owners and operators of the...

  3. 40 CFR 60.4112 - Changing Hg designated representative and alternate Hg designated representative; changes in...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 6 2010-07-01 2010-07-01 false Changing Hg designated representative and alternate Hg designated representative; changes in owners and operators. 60.4112 Section 60.4112... Generating Units Hg Designated Representative for Hg Budget Sources § 60.4112 Changing Hg...

  4. Comparison of Traditional versus Alternative Preparation of Special Education Teachers

    ERIC Educational Resources Information Center

    Robertson, Janna Siegel; Singleton, Jacques D.

    2010-01-01

    The shortage of special education teachers has prompted the creation of alternative certification programs. The effectiveness of the University of Memphis's (U of M's) 14-year-old alternative Special Education Institute program in preparing teachers to teach and remain in the field was examined. The program was compared to the U of M's traditional…

  5. A Comparison of State Alternative Education Accountability Policies and Frameworks

    ERIC Educational Resources Information Center

    Schlessman, Amy; Hurtado, Kelly

    2012-01-01

    The purpose of this policy study was to report descriptive research on state-level policy and frameworks for accountability systems of alternative education in the United States. The six states; California, Colorado, Texas, Florida, Oklahoma, and North Carolina; identified in the 2010 Jobs for the Futures policy analysis of alternative education…

  6. An alternative feed design for the MRO antenna

    NASA Technical Reports Server (NTRS)

    Imbriale, William A.

    2005-01-01

    NASA's Mars Reconnaissance Orbiter (MRO), scheduled for launch in 2005, will study the history of water on Mars. The current feed design for the 3-meter reflector antenna uses a dielectrically supported disk-on-rod Kaband (32 GHz) feed in the center of an X-band (7.2, 8.4 GHz) corrugated horn. As a potential backup design in case of problems, an alternate feed design for the MRO antenna that does not use any dielectric materials or a disc-on-rod was developed. The design uses a Ka-band Potter Horn in the center of the current Xband MRO corrugated horn. Using the same High-gain reflector assembly, the new feed provides virtually the same X-band gain (within 0.1 db) and more than 1 dB improvement at Ka-band.

  7. Validation of erythromycin microbiological assay using an alternative experimental design.

    PubMed

    Lourenço, Felipe Rebello; Kaneko, Telma Mary; Pinto, Terezinha de Jesus Andreoli

    2007-01-01

    The agar diffusion method, widely used in antibiotic dosage, relates the diameter of the inhibition zone to the dose of the substance assayed. An experimental plan is proposed that may provide better results and an indication of the assay validity. The symmetric or balanced assays (2 x 2) as well as those with interpolation in standard curve (5 x 1) are the main designs used in the dosage of antibiotics. This study proposes an alternative experimental design for erythromycin microbiological assay with the evaluation of the validation parameters of the method referring to linearity, precision, and accuracy. The design proposed (3 x 1) uses 3 doses of standard and 1 dose of sample applied in a unique plate, aggregating the characteristics of the 2 x 2 and 5 x 1 assays. The method was validated for erythromycin microbiological assay through agar diffusion, revealing its adequacy to linearity, precision, and accuracy standards. Likewise, the statistical methods used demonstrated their accordance with the method concerning the parameters evaluated. The 3 x 1 design proved to be adequate for the dosage of erythromycin and thus a good alternative for erythromycin assay. PMID:17760348

  8. Multiple comparisons in complex clinical trial designs.

    PubMed

    Hung, H M James; Wang, Sue-Jane

    2013-05-01

    Multiple comparisons have drawn a great deal of attention in evaluation of statistical evidence in clinical trials for regulatory applications. As the clinical trial methodology is increasingly more complex to properly take into consideration many practical factors, the multiple testing paradigm widely employed for regulatory applications may not suffice to interpret the results of an individual trial and of multiple trials. In a large outcome trial, an increasing need of studying more than one dose complicates a proper application of multiple comparison procedures. Additional challenges surface when a special endpoint, such as mortality, may need to be tested with multiple clinical trials combined, especially under group sequential designs. Another interesting question is how to study mortality or morbidity endpoints together with symptomatic endpoints in an efficient way, where the former type of endpoints are often studied in only one single trial but the latter type of endpoints are usually studied in at least two independent trials. This article is devoted to discussion of insufficiency of such a widely used paradigm applying only per-trial based multiple comparison procedures and to expand the utility of the procedures to such complex trial designs. A number of viable expanded strategies are stipulated. PMID:23620458

  9. An alternative LEU design for the FRM-II

    SciTech Connect

    Hanan, N.A.; Mo, S.C.; Smith, R.S.; Matos, J.E.

    1996-12-01

    The Alternative LEU Design for the FRM-II proposed by the RERTR Program at Argonne National Laboratory (ANL) has a compact core consisting of a single fuel element that uses LEU silicide fuel with a uranium density of 4.5 g/cm{sup 3} and has a power level of 32 MW. Both the HEU design by the Technical University of Munich (TUM) and the alternative LEU design by ANL have the same fuel lifetime (50 days) and the same neutron flux performance. LEU silicide fuel with 4.5 g/cm{sup 3} has been thoroughly tested and is fully-qualified, licensable, and available now for use in a high flux reactor such as the FRM-II. The following issues raised by TUM were addressed in Ref. 1: qualification of HEU and LEU silicide fuels, gamma heating in the heavy water reflector, radiological consequences of larger fission product and plutonium inventories in the LEU core, and cost and schedule. The conclusions of these analyses are summarized below. This paper addresses three additional safety issues that were raised by TUM in Ref. 2: stability of the involute fuel plates, a hypothetical accident involving the configuration of the reflector, and a loss of primary coolant flow transient due to an interrupted power supply. Based on the excellent results for the Alternative LEU Design that were obtained in these analyses, the RERTR Program concludes that all of the major technical issues regarding use of LEU fuel instead of HEU fuel in the FRM-II have been successfully resolved and that it is definitely feasible to use LEU fuel in the FRM-II without compromising the safety or performance of the facility.

  10. Arizona Public Service - Alternative Fuel (Hydrogen) Pilot Plant Design Report

    SciTech Connect

    James E. Francfort

    2003-12-01

    Hydrogen has promise to be the fuel of the future. Its use as a chemical reagent and as a rocket propellant has grown to over eight million metric tons per year in the United States. Although use of hydrogen is abundant, it has not been used extensively as a transportation fuel. To assess the viability of hydrogen as a transportation fuel and the viability of producing hydrogen using off-peak electric energy, Pinnacle West Capital Corporation (PNW) and its electric utility subsidiary, Arizona Public Service (APS) designed, constructed, and operates a hydrogen and compressed natural gas fueling station—the APS Alternative Fuel Pilot Plant. This report summarizes the design of the APS Alternative Fuel Pilot Plant and presents lessons learned from its design and construction. Electric Transportation Applications prepared this report under contract to the U.S. Department of Energy’s Advanced Vehicle Testing Activity. The Idaho National Engineering and Environmental Laboratory manages these activities for the Advanced Vehicle Testing Activity.

  11. An Evaluation of Alternative Designs for a Grid Information Service

    NASA Technical Reports Server (NTRS)

    Smith, Warren; Waheed, Abdul; Meyers, David; Yan, Jerry; Kwak, Dochan (Technical Monitor)

    2001-01-01

    The Globus information service wasn't working well. There were many updates of data from Globus daemons which saturated the single server and users couldn't retrieve information. We created a second server for NASA and Alliance. Things were great on that server, but a bit slow on the other server. We needed to know exactly how the information service was being used. What were the best servers and configurations? This viewgraph presentation gives an overview of the evaluation of alternative designs for a Grid Information Service. Details are given on the workload characterization, methodology used, and the performance evaluation.

  12. 40 CFR 97.413 - Authorization of designated representative and alternate designated representative.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... NOX AND SO2 TRADING PROGRAMS TR NOX Annual Trading Program § 97.413 Authorization of designated representative and alternate designated representative. (a) Except as provided under § 97.415, each TR NOX Annual source, including all TR NOX Annual units at the source, shall have one and only one...

  13. 40 CFR 97.515 - Changing designated representative and alternate designated representative; changes in owners and...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (CONTINUED) FEDERAL NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS TR NOX Ozone Season... the new designated representative and the owners and operators of the TR NOX Ozone Season source and the TR NOX Ozone Season units at the source. (b) Changing alternate designated representative....

  14. 40 CFR 97.513 - Authorization of designated representative and alternate designated representative.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... NOX AND SO2 TRADING PROGRAMS TR NOX Ozone Season Trading Program § 97.513 Authorization of designated representative and alternate designated representative. (a) Except as provided under § 97.515, each TR NOX Ozone Season source, including all TR NOX Ozone Season units at the source, shall have one and only...

  15. 40 CFR 97.613 - Authorization of designated representative and alternate designated representative.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... NOX AND SO2 TRADING PROGRAMS TR SO2 Group 1 Trading Program § 97.613 Authorization of designated representative and alternate designated representative. (a) Except as provided under § 97.615, each TR SO2 Group 1 source, including all TR SO2 Group 1 units at the source, shall have one and only one...

  16. 40 CFR 97.413 - Authorization of designated representative and alternate designated representative.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... NOX AND SO2 TRADING PROGRAMS TR NOX Annual Trading Program § 97.413 Authorization of designated representative and alternate designated representative. (a) Except as provided under § 97.415, each TR NOX Annual source, including all TR NOX Annual units at the source, shall have one and only one...

  17. 40 CFR 97.613 - Authorization of designated representative and alternate designated representative.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... NOX AND SO2 TRADING PROGRAMS TR SO2 Group 1 Trading Program § 97.613 Authorization of designated representative and alternate designated representative. (a) Except as provided under § 97.615, each TR SO2 Group 1 source, including all TR SO2 Group 1 units at the source, shall have one and only one...

  18. 40 CFR 97.513 - Authorization of designated representative and alternate designated representative.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... NOX AND SO2 TRADING PROGRAMS TR NOX Ozone Season Trading Program § 97.513 Authorization of designated representative and alternate designated representative. (a) Except as provided under § 97.515, each TR NOX Ozone Season source, including all TR NOX Ozone Season units at the source, shall have one and only...

  19. 40 CFR 97.515 - Changing designated representative and alternate designated representative; changes in owners and...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (CONTINUED) FEDERAL NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS TR NOX Ozone Season... the new designated representative and the owners and operators of the TR NOX Ozone Season source and the TR NOX Ozone Season units at the source. (b) Changing alternate designated representative....

  20. 40 CFR 97.515 - Changing designated representative and alternate designated representative; changes in owners and...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (CONTINUED) FEDERAL NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS TR NOX Ozone Season... the new designated representative and the owners and operators of the TR NOX Ozone Season source and the TR NOX Ozone Season units at the source. (b) Changing alternate designated representative....

  1. 40 CFR 97.613 - Authorization of designated representative and alternate designated representative.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... NOX AND SO2 TRADING PROGRAMS TR SO2 Group 1 Trading Program § 97.613 Authorization of designated representative and alternate designated representative. (a) Except as provided under § 97.615, each TR SO2 Group 1 source, including all TR SO2 Group 1 units at the source, shall have one and only one...

  2. 40 CFR 97.513 - Authorization of designated representative and alternate designated representative.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... NOX AND SO2 TRADING PROGRAMS TR NOX Ozone Season Trading Program § 97.513 Authorization of designated representative and alternate designated representative. (a) Except as provided under § 97.515, each TR NOX Ozone Season source, including all TR NOX Ozone Season units at the source, shall have one and only...

  3. 40 CFR 97.413 - Authorization of designated representative and alternate designated representative.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... NOX AND SO2 TRADING PROGRAMS TR NOX Annual Trading Program § 97.413 Authorization of designated representative and alternate designated representative. (a) Except as provided under § 97.415, each TR NOX Annual source, including all TR NOX Annual units at the source, shall have one and only one...

  4. 40 CFR 96.312 - Changing CAIR designated representative and alternate CAIR designated representative; changes in...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Designated Representative for CAIR NOX Ozone Season Sources § 96.312 Changing CAIR designated representative... CAIR NOX Ozone Season source and the CAIR NOX Ozone Season units at the source. (b) Changing alternate... representative and the owners and operators of the CAIR NOX Ozone Season source and the CAIR NOX Ozone...

  5. 40 CFR 96.312 - Changing CAIR designated representative and alternate CAIR designated representative; changes in...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Designated Representative for CAIR NOX Ozone Season Sources § 96.312 Changing CAIR designated representative... CAIR NOX Ozone Season source and the CAIR NOX Ozone Season units at the source. (b) Changing alternate... representative and the owners and operators of the CAIR NOX Ozone Season source and the CAIR NOX Ozone...

  6. 40 CFR 96.312 - Changing CAIR designated representative and alternate CAIR designated representative; changes in...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Designated Representative for CAIR NOX Ozone Season Sources § 96.312 Changing CAIR designated representative... CAIR NOX Ozone Season source and the CAIR NOX Ozone Season units at the source. (b) Changing alternate... representative and the owners and operators of the CAIR NOX Ozone Season source and the CAIR NOX Ozone...

  7. 40 CFR 96.312 - Changing CAIR designated representative and alternate CAIR designated representative; changes in...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Designated Representative for CAIR NOX Ozone Season Sources § 96.312 Changing CAIR designated representative... CAIR NOX Ozone Season source and the CAIR NOX Ozone Season units at the source. (b) Changing alternate... representative and the owners and operators of the CAIR NOX Ozone Season source and the CAIR NOX Ozone...

  8. 40 CFR 96.312 - Changing CAIR designated representative and alternate CAIR designated representative; changes in...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Designated Representative for CAIR NOX Ozone Season Sources § 96.312 Changing CAIR designated representative... CAIR NOX Ozone Season source and the CAIR NOX Ozone Season units at the source. (b) Changing alternate... representative and the owners and operators of the CAIR NOX Ozone Season source and the CAIR NOX Ozone...

  9. 31 CFR 0.104 - Designated Agency Ethics Official and Alternate Designated Agency Ethics Official.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Standards and Treasury Supplemental Standards and Rules. See 5 CFR 2638.203. The Senior Counsel for Ethics... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Designated Agency Ethics Official and Alternate Designated Agency Ethics Official. 0.104 Section 0.104 Money and Finance: Treasury Office of...

  10. 31 CFR 0.104 - Designated Agency Ethics Official and Alternate Designated Agency Ethics Official.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Standards and Treasury Supplemental Standards and Rules. See 5 CFR 2638.203. The Senior Counsel for Ethics... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false Designated Agency Ethics Official and Alternate Designated Agency Ethics Official. 0.104 Section 0.104 Money and Finance: Treasury Office of...

  11. 31 CFR 0.104 - Designated Agency Ethics Official and Alternate Designated Agency Ethics Official.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Standards and Treasury Supplemental Standards and Rules. See 5 CFR 2638.203. The Senior Counsel for Ethics... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false Designated Agency Ethics Official and Alternate Designated Agency Ethics Official. 0.104 Section 0.104 Money and Finance: Treasury Office of...

  12. 31 CFR 0.104 - Designated Agency Ethics Official and Alternate Designated Agency Ethics Official.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Standards and Treasury Supplemental Standards and Rules. See 5 CFR 2638.203. The Senior Counsel for Ethics... 31 Money and Finance: Treasury 1 2012-07-01 2012-07-01 false Designated Agency Ethics Official and Alternate Designated Agency Ethics Official. 0.104 Section 0.104 Money and Finance: Treasury Office of...

  13. 31 CFR 0.104 - Designated Agency Ethics Official and Alternate Designated Agency Ethics Official.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Standards and Treasury Supplemental Standards and Rules. See 5 CFR 2638.203. The Senior Counsel for Ethics... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Designated Agency Ethics Official and Alternate Designated Agency Ethics Official. 0.104 Section 0.104 Money and Finance: Treasury Office of...

  14. COMPARISON OF THE BIOCIDAL EFFICIENCY OF ALTERNATIVE DISINFECTANTS

    EPA Science Inventory

    Of the current potential alternatives to free residual chlorine for drinking water disinfection (ozone, chlorine dioxide, and chloroamines), ozone is the most potent biocide. Chlorine dioxide is about on a par with hypochlorous acid, but in contrast to free residual chloride, its...

  15. Comparison of translation loads for standard and alternative genetic codes

    PubMed Central

    2010-01-01

    Background The (almost) universality of the genetic code is one of the most intriguing properties of cellular life. Nevertheless, several variants of the standard genetic code have been observed, which differ in one or several of 64 codon assignments and occur mainly in mitochondrial genomes and in nuclear genomes of some bacterial and eukaryotic parasites. These variants are usually considered to be the result of non-adaptive evolution. It has been shown that the standard genetic code is preferential to randomly assembled codes for its ability to reduce the effects of errors in protein translation. Results Using a genotype-to-phenotype mapping based on a quantitative model of protein folding, we compare the standard genetic code to seven of its naturally occurring variants with respect to the fitness loss associated to mistranslation and mutation. These fitness losses are computed through computer simulations of protein evolution with mutations that are either neutral or lethal, and different mutation biases, which influence the balance between unfolding and misfolding stability. We show that the alternative codes may produce significantly different mutation and translation loads, particularly for genomes evolving with a rather large mutation bias. Most of the alternative genetic codes are found to be disadvantageous to the standard code, in agreement with the view that the change of genetic code is a mutationally driven event. Nevertheless, one of the studied alternative genetic codes is predicted to be preferable to the standard code for a broad range of mutation biases. Conclusions Our results show that, with one exception, the standard genetic code is generally better able to reduce the translation load than the naturally occurring variants studied here. Besides this exception, some of the other alternative genetic codes are predicted to be better adapted for extreme mutation biases. Hence, the fixation of alternative genetic codes might be a neutral or nearly

  16. Probabilistic comparison of alternative characterization technologies at the Fernald Uranium-in-Soils Integrated Demonstration Project

    SciTech Connect

    Rautman, C.A.; McGraw, M.A.; Istok, J.D.; Sigda, J.M.; Kaplan, P.G.

    1993-12-31

    The performance of four alternative characterization technologies proposed for use in characterization of surficial uranium contamination in soil at the Incinerator and Drum Baling Areas at the Fernald Environmental Management Project in southwestern Ohio has been evaluated using a probabilistic, risk-based decision-analysis methodology. The basis of comparison is to minimize a computed total cost for environmental cleanup. This total-cost-based approach provides a framework for evaluating the trade-offs among remedial investigation, the remedial design, and the risk of regulatory penalties. The approach explicitly recognizes the value of information provided by remedial investigation; additional measurements are only valuable to the extent that the information they provide reduces total cost.

  17. Total System Performance Assessment: Enhanced Design Alternative V

    SciTech Connect

    N. Erb; S. Miller; V. Vallikat

    1999-07-08

    This calculation documents the total system performance assessment modeling of Enhanced Design Analysis (EDA) V. EDA V is based on the TSPA-VA base design which has been modified with higher thermal loading, a quartz sand invert, and line loading with 21 PWR waste packages that have 2-cm thick titanium grade 7 corrosion resistance material (CRM) drip shields placed over dual-layer waste packages composed of 'inside out' VA reference material (CRWMS M and O 1999a). This document details the changes and assumptions made to the VA reference Performance Assessment Model (CRWMS M and O 1998a) to incorporate the design changes detailed for EDA V. The performance measure for this evaluation is expected value dose-rate history. Time histories of dose rate are presented for EDA V and a Defense in Depth (DID) analysis base on EDA V. Additional details concerning the Enhanced Design Alternative II are provided in the 'LADS 3-12 Requests' interoffice correspondence (CRWMS M and O 1999a).

  18. Alternative comparison, analysis, and evaluation of solid waste and materials system alternatives

    SciTech Connect

    Brothers, A.J.

    1995-09-01

    This paper presents a comprehensive analysis of the impact of solid waste technical options on values and objectives that are important to the public. It is written in support of the Solid Waste and Materials Systems Alternatives Study (WHC, 1995). Described are the values that were identified, the major programmatic risks, how the impacts were measured, the performance of alternatives, the methodology used for the analysis, and the implications of the results. Decision analysis was used to guide the collection and analysis of data and the logic of the evaluation. Decision analysis is a structured process for the analysis and evaluation of alternatives. It is theoretically grounded in a set of axioms that capture the basic principles of decision making (von Neuman and Morgenstern 1947). Decision analysis objectively specifies what factors are to be considered, how they are to be measured and evaluated, and heir relative importance. The result is an analysis in which the underlying rationale or logic upon which the decision is based is made explicit. This makes possible open discussion of the decision basis in which facts and values are clearly distinguished, resulting in a well- documented decision that can be clearly explained and justified. The strategy of decision analysis is to analyze the various components relevant to the decision separately and then integrate the individual judgments to arrive at an overall decision. This assures that all the relevant factors are identified and their relative importance is considered. The procedure for obtaining the individual judgments, and the decision rules, for combining them and evaluating alternatives, have both theoretical and empirical foundation in mathematics, economics, and psychology.

  19. Screening of one-well hydraulic barrier design alternatives.

    PubMed

    Rubin, Hillel; Shoemaker, Christine A; Köngeter, Jürgen

    2008-01-01

    Abstract This study develops a robust method for screening one-well hydraulic barrier design alternatives that can be easily computed without a numerical simulation model. The paper outlines the general method and shows its implementation with hydraulic barriers using a single pumping well. For such barriers, the method is easily computable with spreadsheets and/or charts depicted within the paper and posted online. The method applies the potential flow theory, which leads to using a curvilinear coordinate system for all types of calculations. For contaminant transport calculations, the method applies the boundary layer theory. For calculations of aquifer remediation, the method refers to bulk characteristics of the domain. As an example, the method has been applied to calculate the possible containment of a wide part of the coastal plain aquifer in Israel, which is contaminated by entrapped kerosene (a light nonaqueous phase liquid). PMID:18266729

  20. A Cost Comparison of Alternative Approaches to Distance Education in Developing Countries

    NASA Technical Reports Server (NTRS)

    Ventre, Gerard G.; Kalu, Alex

    1996-01-01

    This paper presents a cost comparison of three approaches to two-way interactive distance learning systems for developing countries. Included are costs for distance learning hardware, terrestrial and satellite communication links, and designing instruction for two-way interactive courses. As part of this project, FSEC is developing a 30-hour course in photovoltaic system design that will be used in a variety of experiments using the Advanced Communications Technology Satellite (ACTS). A primary goal of the project is to develop an instructional design and delivery model that can be used for other education and training programs. Over two-thirds of the world photovoltaics market is in developing countries. One of the objectives of this NASA-sponsored project was to develop new and better energy education programs that take advantage of advances in telecommunications and computer technology. The combination of desktop video systems and the sharing of computer applications software is of special interest. Research is being performed to evaluate the effectiveness of some of these technologies as part of this project. The design of the distance learning origination and receive sites discussed in this paper were influenced by the educational community's growing interest in distance education. The following approach was used to develop comparative costs for delivering interactive distance education to developing countries: (1) Representative target locations for receive sites were chosen. The originating site was assumed to be Cocoa, Florida, where FSEC is located; (2) A range of course development costs were determined; (3) The cost of equipment for three alternative two-way interactive distance learning system configurations was determined or estimated. The types of system configurations ranged from a PC-based system that allows instructors to originate instruction from their office using desktop video and shared application software, to a high cost system that uses a

  1. UTILITY BOILER DESIGN/COST COMPARISON: FLUIDIZED-BED COMBUSTION VS. FLUE GAS DESULFURIZATION

    EPA Science Inventory

    The report gives results of a conceptual design, performance, and cost comparison of utility scale (750-925 MWe) coal-burning power plants employing three alternative technologies: conventional boiler with a stack gas scrubber (CWS), atmospheric-pressure fluidized-bed combustion ...

  2. A life-cycle comparison of alternative automobile fuels.

    PubMed

    MacLean, H L; Lave, L B; Lankey, R; Joshi, S

    2000-10-01

    We examine the life cycles of gasoline, diesel, compressed natural gas (CNG), and ethanol (C2H5OH)-fueled internal combustion engine (ICE) automobiles. Port and direct injection and spark and compression ignition engines are examined. We investigate diesel fuel from both petroleum and biosources as well as C2H5OH from corn, herbaceous bio-mass, and woody biomass. The baseline vehicle is a gasoline-fueled 1998 Ford Taurus. We optimize the other fuel/powertrain combinations for each specific fuel as a part of making the vehicles comparable to the baseline in terms of range, emissions level, and vehicle lifetime. Life-cycle calculations are done using the economic input-output life-cycle analysis (EIO-LCA) software; fuel cycles and vehicle end-of-life stages are based on published model results. We find that recent advances in gasoline vehicles, the low petroleum price, and the extensive gasoline infrastructure make it difficult for any alternative fuel to become commercially viable. The most attractive alternative fuel is compressed natural gas because it is less expensive than gasoline, has lower regulated pollutant and toxics emissions, produces less greenhouse gas (GHG) emissions, and is available in North America in large quantities. However, the bulk and weight of gas storage cylinders required for the vehicle to attain a range comparable to that of gasoline vehicles necessitates a redesign of the engine and chassis. Additional natural gas transportation and distribution infrastructure is required for large-scale use of natural gas for transportation. Diesel engines are extremely attractive in terms of energy efficiency, but expert judgment is divided on whether these engines will be able to meet strict emissions standards, even with reformulated fuel. The attractiveness of direct injection engines depends on their being able to meet strict emissions standards without losing their greater efficiency. Biofuels offer lower GHG emissions, are sustainable, and

  3. A comparison of alternative multiobjective calibration strategies for hydrological modeling

    NASA Astrophysics Data System (ADS)

    Fenicia, Fabrizio; Savenije, Hubert H. G.; Matgen, Patrick; Pfister, Laurent

    2007-03-01

    A conceptual hydrological model structure contains several parameters that have to be estimated through matching observed and modeled watershed behavior in a calibration process. The requirement that a model simulation matches different aspects of system response at the same time has led the calibration problem toward a multiobjective approach. In this work we compare two multiobjective calibration approaches, each of which represents a different calibration philosophy. The first calibration approach is based on the concept of Pareto optimality and consists of calibrating all parameters with respect to a common set of objectives in one calibration stage. This approach results in a set of Pareto-optimal solutions representing the trade-offs between the selected calibration objectives. The second is a stepped calibration approach (SCA), which implies a stepwise calibration of sets of parameters that are associated with specific aspects of the system response. This approach replicates the steps followed by a hydrologist in manual calibration and develops a single solution. The comparison is performed considering the same set of objectives for the two approaches and two model structures of a different level of complexity. The difference in the two approaches, their reciprocal utility, and the practical implications involved in their application are analyzed and discussed using the Hesperange catchment case, an experimental basin in the Alzette River basin in Luxembourg. We show that the two approaches are not necessarily conflicting but can be complementary. The first approach provides useful information about the deficiencies of a model structure and therefore helps the model development, while the second attempts at determining a solution that is consistent with the data available. We also show that with increasing model complexity it becomes possible to reproduce the observations more accurately. As a result, the solutions for the different calibration objectives

  4. Cost comparison of the satellite power system and six alternative technologies

    SciTech Connect

    Wolsko, T.; Samsa, M.

    1981-04-01

    A framework is described for comparing the Satellite Power System (SPS) with various projected alternative energy sources on the basis of technical possibility, economic viability, and social and environmental acceptability. Each of the following energy sources is briefly described: conventional coal, light water reactor, coal gasification/combined cycle, liquid-metal fast-breeder reactor, central station terrestrial photovoltaic, fusion, and the SPS. The analysis consists of comparison of characterizations, side-by-side analysis, and alternative futures analysis. (LEW)

  5. Supports and Enhancements Designed for Alternative School Programming

    ERIC Educational Resources Information Center

    Menendez, Anthony L.

    2007-01-01

    In this informational survey, the author briefly explores the needs of professional staff and administrators who serve students in alternative educational settings and special education and provides a listing of helpful Internet resources. Initially, the author provides general information concerning the current state of alternative education…

  6. RIP INPUT TABLES FROM WAPDEG FOR LA DESIGN SELECTION: ENHANCED DESIGN ALTERNATIVE V

    SciTech Connect

    K. Mon

    1999-07-01

    The purpose of this calculation is to document (1) the Waste Package Degradation (WAPDEG) version 3.09 (CRWMS M&O 1998b, Software Routine Report for WAPDEG (Version 3.09)) simulations used to analyze degradation and failure of 2-cm thick titanium grade 7 corrosion resistant material (CRM) drip shields (that are placed over waste packages composed of a 2-cm thick Alloy 22 corrosion resistant material (CRM) as the outer barrier and an unspecified material to provide structural support as the inner barrier) as well as degradation and failure of the waste packages themselves, and (2) post-processing of these results into tables of drip shield/waste package degradation time histories suitable for use as input into the Integrated Probabilistic Simulator for Environmental Systems (RIP) version 5.19.01 (Golder Associates 1998) computer code. Performance credit of the inner barrier material is not taken in this calculation. This calculation supports Performance Assessment analysis of the License Application Design Selection (LADS) Enhanced Design Alternative V. Additional details concerning the Enhanced Design Alternative V are provided in a Design Input Request (CRWMS M&O 1999e, Design Input Request for LADS Phase II EDA Evaluations, Item 3).

  7. Defect printability of alternating phase-shift mask: a critical comparison of simulation and experiment

    NASA Astrophysics Data System (ADS)

    Ozawa, Ken; Komizo, Tooru; Kikuchi, Koji; Ohnuma, Hidetoshi; Kawahira, Hiroichi

    2002-07-01

    An alternative phase shift mask (alt-PSM) is a promising device for extending optical lithography to finer design rules. There have been few reports, however, on the mask's ability to identify phase defects. We report here an alt-PSM of a dual-trench type for KrF exposure, with programmed quartz defects used to evaluate defect printability by measuring aerial images with a Zeiss MSM100 measuring system. The experimental results are simulated using the TEMPEST program. First, a critical comparison of the simulation and the experiment is conducted. The actual measured topography of quartz defects are used in the simulation. Moreover, a general simulation study on defect printability using an alt-PSM for ArF exposure is conducted. The defect dimensions, which produce critical CD errors are determined by simulation that takes into account the full 3-dimensional structure of phase defects as well as a simplified structure. The critical dimensions of an isolated defect identified by the alt-PSM of a single-trench type for ArF exposure are 240 nm in bottom diameter and 50 degrees in height (phase) for the cylindrical shape and 240 nm in bottom diameter and 90 degrees in height (phase) for the rotating trapezoidal shape, where the CD error limit is +/- 5%.

  8. Modular Design/Phased Construction Alternative Evaluation Report

    SciTech Connect

    Schwartztrauber, K.

    1999-05-28

    Modular design concepts are being considered for the license application during the surface facility design phase of the Monitored Geologic Repository (MGR). The Viability Assessment (VA) design is used as the reference design for the report. The primary objectives are to spread construction of the WHB and the subsurface repository over time to reduce annual project costs, and to provide a cost-effective design for the surface facilities that supports waste emplacement starting in the year 2010.

  9. The Validity and Precision of the Comparative Interrupted Time-Series Design: Three Within-Study Comparisons

    ERIC Educational Resources Information Center

    St. Clair, Travis; Hallberg, Kelly; Cook, Thomas D.

    2016-01-01

    We explore the conditions under which short, comparative interrupted time-series (CITS) designs represent valid alternatives to randomized experiments in educational evaluations. To do so, we conduct three within-study comparisons, each of which uses a unique data set to test the validity of the CITS design by comparing its causal estimates to…

  10. An alternating treatment comparison of oral and total communications training programs with echolalic autistic children.

    PubMed Central

    Barrera, R D; Sulzer-Azaroff, B

    1983-01-01

    An alternating treatment comparison was conducted of the relative effectiveness of oral and total communication training models for teaching expressive labeling skills to three echolalic autistic children. The results of this comparison demonstrated that total communication proved to be the most successful approach with each of the subjects. In addition, the replication of these findings both within and across subjects suggest that total communication may be, in general, the most effective of these two training models for teaching basic vocal language skills to echolalic children. A number of hypotheses are presented that may provide a basis for the demonstrated effect. PMID:6654770

  11. Alternative positron-target design for electron-positron colliders

    SciTech Connect

    Donahue, R.J. ); Nelson, W.R. )

    1991-04-01

    Current electron-positron linear colliders are limited in luminosity by the number of positrons which can be generated from targets presently used. This paper examines the possibility of using an alternate wire-target geometry for the production of positrons via an electron-induced electromagnetic cascade shower. 39 refs., 38 figs., 5 tabs.

  12. Designs for Emerging Order in Qualitative Research: An Alternative Perspective.

    ERIC Educational Resources Information Center

    Sawada, Daiyo; Pothier, Yvonne

    As an alternative to traditional methodology in education research, an approach transcending the distinction between quantitative and qualitative perspectives is suggested. Emerging insights in qualitative research can be enhanced by beginning with the phenomenon of emerging order. The theory of Dissipative Structures suggests that research…

  13. Alternate space shuttle concepts study: Design requirements and phased programs evaluation

    NASA Technical Reports Server (NTRS)

    1971-01-01

    A study to determine program and technical alternatives to the design of the space shuttle orbiter is described. The alternatives include a phased approach, involving orbiter development and operation with an expendable booster for an interim period, as well as design variations to the basic vehicle. The space shuttle orbiter configurations and predicted performance parameters are presented.

  14. EDIN design study alternate space shuttle booster replacement concepts. Volume 2: Design simulation results

    NASA Technical Reports Server (NTRS)

    Demakes, P. T.; Hirsch, G. N.; Stewart, W. A.; Glatt, C. R.

    1976-01-01

    Historical weight estimating relationships were developed for the liquid rocket booster (LRB) using Saturn technology, and modified as required to support the EDIN05 study. Mission performance was computed using February 1975 shuttle configuration groundrules to allow reasonable comparison of the existing shuttle with the EDIN05 designs. The launch trajectory was constrained to pass through both the RTLS/AOA and main engine cut-off points. Performance analysis was based on a point design trajectory model which optimized initial tilt rate and exo-atmospheric pitch profile. A gravity turn was employed during the boost phase in place of the shuttle angle-of-attack profile. Engine throttling add/or shutdown was used to constrain dynamic pressure and/or longitudinal acceleration where necessary.

  15. Comparison of oil removal in surfactant alternating gas with water alternating gas, water flooding and gas flooding in secondary oil recovery process

    PubMed Central

    Salehi, Mehdi Mohammad; Safarzadeh, Mohammad Amin; Sahraei, Eghbal; Nejad, Seyyed Alireza Tabatabaei

    2014-01-01

    Growing oil prices coupled with large amounts of residual oil after operating common enhanced oil recovery methods has made using methods with higher operational cost economically feasible. Nitrogen is one of the gases used in both miscible and immiscible gas injection process in oil reservoir. In heterogeneous formations gas tends to breakthrough early in production wells due to overriding, fingering and channeling. Surfactant alternating gas (SAG) injection is one of the methods commonly used to decrease this problem. Foam which is formed on the contact of nitrogen and surfactant increases viscosity of injected gas. This increases the oil–gas contact and sweep efficiency, although adsorption of surfactant on rock surface can causes difficulties and increases costs of process. Many parameters must be considered in design of SAG process. One of the most important parameters is SAG ratio that should be in optimum value to improve the flooding efficiency. In this study, initially the concentration of surfactant was optimized due to minimization of adsorption on rock surface which results in lower cost of surfactant. So, different sodium dodecyl sulfate (SDS) concentrations of 100, 500, 1000, 2000, 3000 and 4000 ppm were used to obtain the optimum concentration at 70 °C and 144.74×105 Pa. A simple, clean and relatively fast spectrophotometric method was used for determination of surfactant which is based on the formation of an ion-pair. Then the effect of surfactant to gas volume ratio on oil recovery in secondary oil recovery process during execution of immiscible surfactant alternating gas injection was examined experimentally. The experiments were performed with sand pack under certain temperature, pressure and constant rate. Experiments were performed with surfactant to gas ratio of 1:1, 1:2, 1:3, 2:1 and 3:1 and 1.2 pore volume injected. Then, comparisons were made between obtained results (SAG) with water flooding, gas flooding and water alternating gas

  16. Design Alternatives for a Free Electron Laser Facility

    SciTech Connect

    Jacobs, K; Bosch, R A; Eisert, D; Fisher, M V; Green, M A; Keil, R G; Kleman, K J; Kulpin, J G; Rogers, G C; Wehlitz, R; Chiang, T; Miller, T J; Lawler, J E; Yavuz, D; Legg, R A; York, R C

    2012-07-01

    The University of Wisconsin-Madison is continuing design efforts for a vacuum ultraviolet/X-ray Free Electron Laser facility. The design incorporates seeding the FEL to provide fully coherent photon output at energies up to {approx}1 keV. The focus of the present work is to minimize the cost of the facility while preserving its performance. To achieve this we are exploring variations in the electron beam driver for the FEL, in undulator design, and in the seeding mechanism. Design optimizations and trade-offs between the various technologies and how they affect the FEL scientific program will be presented.

  17. NPS alternate techsat satellite, design project for AE-4871

    NASA Technical Reports Server (NTRS)

    1993-01-01

    This project was completed as part of AE-4871, Advanced Spacecraft Design. The intent of the course is to provide experience in the design of all the major components in a spacecraft system. Team members were given responsibility for the design of one of the six primary subsystems: power, structures, propulsion, attitude control, telemetry, tracking and control (TT&C), and thermal control. In addition, a single member worked on configuration control, launch vehicle integration, and a spacecraft test plan. Given an eleven week time constraint, a preliminary design of each subsystem was completed. Where possible, possible component selections were also made. Assistance for this project came principally from the Naval Research Laboratory's Spacecraft Technology Branch. Specific information on components was solicited from representatives in industry. The design project centers on a general purpose satellite bus that is currently being sought by the Strategic Defense Initiative.

  18. Implications of solar energy alternatives for community design

    SciTech Connect

    Santos, A.; Steinitz, C.

    1980-06-01

    A graduate-level studio at the Harvard School of Design explored how a policy of solar-based energy independence will influence the design of a new community of approximately 4500 housing units and other uses. Three large sites outside Tucson (a cooling problem), Atlanta (a humidity problem), and Boston (a heating problem) were selected. Each is typical of its region. A single program was assumed and designed for. Each site had two teams, one following a compact approach and one following a more dispersed approach. Each was free to choose the most appropriate mix of (solar) technology and scale, and was free to integrate energy and community in the design as it saw fit. These choice and integration issues are key areas where our experience may be of interest to those involved in community design and solar energy.

  19. Alternate bearing design fabrication and test program, exhibit B

    NASA Technical Reports Server (NTRS)

    1978-01-01

    A 50 ft-lb-sec (FPS) reaction wheel was modified with an ironless armature brushless dc motor and a magnetic bearing suspension. The purpose was to demonstrate the performance of an alternate bearing concept, i.e., a magnetic bearing suspension, which could be used in Skylab type CMG's to meet the attitude control requirements of long term space stations. A magnetic suspension was built, installed and tested in the 50 FPS reaction wheel. A secondary effort included the build and test of a compatible reaction wheel motor. Performance characteristics of both are presented and discussed.

  20. Alternative Designs for the NSLS-II Injection Straight Section

    SciTech Connect

    Shaftan,T.; Heese, R.; Weihreter, E.; Willeke, F.; Rehak, M.; Meier, R.; Fliller, R.; Johnson, E. D.

    2009-05-04

    Brookhaven National Laboratory (BNL) is developing a state-of-the-art 3 GeV synchrotron light source, the NSLS-II [1]. The 9.3 meter-long injection straight section of its storage ring now fits a conventional injection set-up consisting of four kickers producing a closed bump, together with a DC septum and a pulsed septum. In this paper, we analyze an alternative option based on injection via a pulsed sextupole magnet. We discuss the dynamics of the injected and stored beams and, subsequently, the magnet's specifications and tolerances. We conclude by summarized the advantages and drawbacks of each injection scheme.

  1. How Can Comparison Groups Strengthen Regression Discontinuity Designs?

    ERIC Educational Resources Information Center

    Wing, Coady; Cook, Thomas D.

    2011-01-01

    In this paper, the authors examine some of the ways that different types of non-equivalent comparison groups can be used to strengthen causal inferences based on regression discontinuity design (RDD). First, they consider a design that incorporates pre-test data on assignment scores and outcomes that were collected either before the treatment…

  2. An Alternating Treatment Comparison of Minimal and Maximal Opposition Sound Selection in Turkish Phonological Disorders

    ERIC Educational Resources Information Center

    Topbas, Seyhun; Unal, Ozlem

    2010-01-01

    A single-subject alternating treatment design in combination with a staggered multiple baseline model across subjects was implemented with two 6:0 year-old girls, monozygotic twins, who were referred to a university clinic for evaluation and treatment. The treatment programme was structured according to variants of "minimal pair contrast…

  3. Alternative Spring Break at the Savannah College of Art and Design: Engaging Art and Design Students in Community Service

    ERIC Educational Resources Information Center

    Hoey, J. Joseph; Feld-Gore, Jeffrey A.

    2014-01-01

    This chapter describes the impact of an alternative spring break program on students at the Savannah College of Art and Design over a set of years as well as its effectiveness as a service-learning tool.

  4. Comparisons of luminaires: Efficacies and system design

    NASA Astrophysics Data System (ADS)

    Albright, L. D.; Both, A. J.

    1994-03-01

    Lighting designs for architectural (aesthetic) purposes, vision and safety, and plant growth have many features in common but several crucial ones that are not. The human eye is very sensitive to the color (wavelength) of light, whereas plants are less so. There are morphological reactions, particularly to the red and blue portions of the light spectrum but, in general, plants appear to accept and use light for photosynthesis everywhere over the PAR region of the spectrum. In contrast, the human eye interprets light intensity on a logarithmic scale, making people insensitive to significant differences of light intensity. As a rough rule, light intensity must change by 30 to 50% for the human eye to recognize the difference. Plants respond much more linearly to light energy, at least at intensities below photosynthetic saturation. Thus, intensity differences not noticeable to the human eye can have significant effects on total plant growth and yield, and crop timing. These factors make luminaire selection and lighting system design particularly important when designing supplemental lighting systems for plant growth. Supplemental lighting for plant growth on the scale of commercial greenhouses is a relatively expensive undertaking. Light intensities are often much higher than required for task (vision) lighting, which increases both installation and operating costs. However, and especially in the northern regions of the United States (and Canada, Europe, etc.), supplemental lighting during winter may be necessary to produce certain crops (e.g., tomatoes) and very useful to achieve full plant growth potential and crop timing with most other greenhouse crops. Operating costs over the life of a luminaire typically will exceed the initial investment, making lighting efficacy a major consideration. This report reviews tests completed to evaluate the efficiencies of various commercially-available High-Pressure Sodium luminaires, and then describes the results of using a

  5. Comparisons of luminaires: Efficacies and system design

    NASA Technical Reports Server (NTRS)

    Albright, L. D.; Both, A. J.

    1994-01-01

    Lighting designs for architectural (aesthetic) purposes, vision and safety, and plant growth have many features in common but several crucial ones that are not. The human eye is very sensitive to the color (wavelength) of light, whereas plants are less so. There are morphological reactions, particularly to the red and blue portions of the light spectrum but, in general, plants appear to accept and use light for photosynthesis everywhere over the PAR region of the spectrum. In contrast, the human eye interprets light intensity on a logarithmic scale, making people insensitive to significant differences of light intensity. As a rough rule, light intensity must change by 30 to 50% for the human eye to recognize the difference. Plants respond much more linearly to light energy, at least at intensities below photosynthetic saturation. Thus, intensity differences not noticeable to the human eye can have significant effects on total plant growth and yield, and crop timing. These factors make luminaire selection and lighting system design particularly important when designing supplemental lighting systems for plant growth. Supplemental lighting for plant growth on the scale of commercial greenhouses is a relatively expensive undertaking. Light intensities are often much higher than required for task (vision) lighting, which increases both installation and operating costs. However, and especially in the northern regions of the United States (and Canada, Europe, etc.), supplemental lighting during winter may be necessary to produce certain crops (e.g., tomatoes) and very useful to achieve full plant growth potential and crop timing with most other greenhouse crops. Operating costs over the life of a luminaire typically will exceed the initial investment, making lighting efficacy a major consideration. This report reviews tests completed to evaluate the efficiencies of various commercially-available High-Pressure Sodium luminaires, and then describes the results of using a

  6. Design and Implementation Considerations for Alternative Teacher Compensation Programs

    ERIC Educational Resources Information Center

    Brodsky, Andrew; DeCesare, Dale; Kramer-Wine, Jennifer

    2010-01-01

    Over the past decade, educators and policymakers have used a variety of approaches to designing and implementing teacher compensation programs. These approaches include federal incentive funds, state-level programs, and district initiatives. This article reviews 6 such programs in order to identify themes and draw conclusions relevant to…

  7. Design element alternatives for stress-management intervention websites.

    PubMed

    Williams, Reg A; Gatien, Gary; Hagerty, Bonnie

    2011-01-01

    Typical public and military-sponsored websites on stress and depression tend to be prescriptive. Some require users to complete lengthy questionnaires. Others reproduce printed flyers, papers, or educational materials not adapted for online use. Some websites require users to follow a prescribed path through the material. Stress Gym was developed as a first-level, evidence-based, website intervention to help U.S. military members learn how to manage mild to moderate stress and depressive symptoms using a self-help intervention with progress tracking and 24/7 availablility. It was designed using web-based, health-management intervention design elements that have been proven effective and users reported they prefer. These included interactivity, self-pacing, and pleasing aesthetics. Users learned how to manage stress by accessing modules they choose, and by practicing proven stress management strategies interactively immediately after login. Test results of Stress Gym with Navy members demonstrated that it was effective, with significant decreases in reported perceived stress levels from baseline to follow-up assessment. Stress Gym used design elements that may serve as a model for future websites to emulate and improve upon, and as a template against which to compare and contrast the design and functionality of future online, health-intervention websites. PMID:21684565

  8. ALTERNATE MATERIALS IN DESIGN OF RADIOACTIVE MATERIAL PACKAGES

    SciTech Connect

    Blanton, P.; Eberl, K.

    2010-07-09

    This paper presents a summary of design and testing of material and composites for use in radioactive material packages. These materials provide thermal protection and provide structural integrity and energy absorption to the package during normal and hypothetical accident condition events as required by Title 10 Part 71 of the Code of Federal Regulations. Testing of packages comprising these materials is summarized.

  9. 10 CFR 61.54 - Alternative requirements for design and operations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Alternative requirements for design and operations. 61.54 Section 61.54 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE Technical Requirements for Land Disposal Facilities § 61.54 Alternative requirements...

  10. 10 CFR 61.54 - Alternative requirements for design and operations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Alternative requirements for design and operations. 61.54 Section 61.54 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE Technical Requirements for Land Disposal Facilities § 61.54 Alternative requirements...

  11. 10 CFR 61.54 - Alternative requirements for design and operations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Alternative requirements for design and operations. 61.54 Section 61.54 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE Technical Requirements for Land Disposal Facilities § 61.54 Alternative requirements...

  12. 10 CFR 61.54 - Alternative requirements for design and operations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Alternative requirements for design and operations. 61.54 Section 61.54 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE Technical Requirements for Land Disposal Facilities § 61.54 Alternative requirements...

  13. 10 CFR 61.54 - Alternative requirements for design and operations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Alternative requirements for design and operations. 61.54 Section 61.54 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE Technical Requirements for Land Disposal Facilities § 61.54 Alternative requirements...

  14. Alternatives generation and analysis for phase I intermediate waste feed staging system design requirements

    SciTech Connect

    Britton, M.D.

    1996-10-02

    This document provides; a decision analysis summary; problem statement; constraints, requirements, and assumptions; decision criteria; intermediate waste feed staging system options and alternatives generation and screening; intermediate waste feed staging system design concepts; intermediate waste feed staging system alternative evaluation and analysis; and open issues and actions.

  15. License Application Design Selection Enhanced Design Alternative V: Very High Thermal Loading

    SciTech Connect

    C. L. Linden

    1999-06-22

    The major goals of Enhanced Design Alternative (EDA) V are to keep the temperature of the cladding on the spent nuclear fuel (SNF) within the waste package below 350 C (Section 4.2.3), the temperature of the emplacement drift walls below 225 C (Section 4.2.3), and to keep the emplacement drifts dry for several thousand years. In addition, the design would produce relatively consistent heat output from waste package to waste package and ensure that waste package thermal outputs are spread more evenly across the repository. The design would also provide defense in depth (Section 5.3). The goals of this design would be achieved by the combination of design features described below. This EDA would have an areal mass loading (AML) of 150 metric tons of uranium equivalent (MTU) per acre (Section 4.1.16) as opposed to the 85 MTU/acre in the Viability Assessment (VA) reference design. To achieve this loading and the elements necessary to the EDA's overall goals, the design would require approximately 420 acres of emplacement area, within the lower repository block (Appendix A, Section A.2). A conceptual layout was developed for EDA V (Section 5.4.3). The layout, as shown in Figure 2, contains openings that are sized and arranged in a similar configuration as the VA reference design. A total of 54 emplacement drifts will be required for emplacement of the 70,000 MTU of spent nuclear fuel and high level waste packages. A total of four ventilation shafts, one intake and three exhausts are anticipated for the layout in order to provide sufficient air quantities to the emplacement drifts. Two exhaust mains will be located below the level of the emplacement drifts to provide exhaust from the emplacement drifts. In addition, the evaluation has confirmed that the decision to close the repository is possible 50 years after start of emplacement (Section 5.7.5). The licensing and preclosure period encompassed by the Mined Geologic Repository (MGR) extends from the year 2002 through

  16. Intelligent break-even analysis system for comparison of manufacturing alternatives

    NASA Astrophysics Data System (ADS)

    Wang, Kesheng; Zhang, Shiqi; Lei, Bing

    1995-08-01

    This paper describes the construction of an intelligent break-even analysis system for comparison of manufacturing alternatives. Such a system integrates expert system with existing PC software tools, for example, spreadsheet, database and conventional programming packages, etc. and is used to help managers to make the decision in production process. The system is developed by using KnowledgePro, a PC-based intelligent system development environment. The advantages offered by the system are: (1) their ability to deal with both quantitative computations and qualitative reasoning; (2) their suitability for small and middle size enterprise.

  17. Alternate architectures and technologies for Intelsat type DSI design

    NASA Astrophysics Data System (ADS)

    Keelty, J. M.; Hatzigeorgiou, S.

    1983-01-01

    The architectural choices in the unit design have to do with the amount of storage and the type of storage in the unit, the type of high-speed interface, the type of echo-protection features, the FEC encoding, and the degree of human interface for testing and maintenance. Since the interpolation process takes time, the unit is by necessity memory-oriented, and an efficient choice of memory architecture is cardinal. The two principal design choices are referred to as 'oorder and storage' and 'storage and order.' Store-and-order implies storage of data on all received channels (regardless of whether they are to be processed), followed by data routing for selected channels. Order-and-store implies immediate selection of the traffic to be processed. The architecture is also affected by the choice of interface between the DSI (digital speech interpolation) and the 'satellite' side equipment. Although the principal choice is between word- and bit-oriented data transmission, tradeoffs exist involving handshaking for control signals as well.

  18. Space Shuttle Main Engine (SSME) alternate turbopump design and development

    NASA Astrophysics Data System (ADS)

    Mitchell, J. P.; Price, J. L.

    1992-08-01

    The development of high-pressure turbopumps for the 400,000-lb-thrust class Space Shuttle Main Engine (SSME) is examined with attention given to reducing maintenance and improving turbopump life. The high-pressure turbopump is designed with single-crystal turbine blades, an integral disk/shaft, a stiff rotor with larger bearings, and advanced homogeneous structural housings. The High-pressure Fuel Turbopump is shown to raise the fuel pressure significantly to enhance injection at all thrust levels, and the High-pressure Oxidizer Turbopump enhances oxidizer pressure for adequate injection at all power levels. Both of the turbopumps are tested in a high-pressure facility with attention given to start and shutdown characteristics, and breakaway torque and inertias are shown to influence combustor priming, ignition, temperature spikes, and thrust.

  19. An alternate method for designing dipole magnet ends

    SciTech Connect

    Pope, W.L.; Green, M.A.; Peters, C.; Caspi, S.; Taylor, C.E.

    1988-08-01

    Small bore superconducting dipole magnets, such as those for the SSC, often have problems in the ends. These problems can often be alleviated by spreading out the end windings so that the conductor sees less deformation. This paper presents a new procedure for designing dipole magnet ends which can be applied to magnets with either cylindrical or conical bulged ends to have integrated field multipoles which meet the constraints imposed by the SSC lattice. The method described here permits one to couple existing multiparameter optimization routines (i.e., MINUIT with suitable independent parameter constraints) with a computer code DIPEND, which describes the multiples, so that one can meet any reasonable objective (i.e., minimizing integrated sextupole and decapole). This paper will describe how the computer method was used to analyze the bulged conical ends for an SSC dipole. 6 refs, 6 figs, 2 tabs.

  20. A Comparison of Alternative Distributed Dynamic Cluster Formation Techniques for Industrial Wireless Sensor Networks.

    PubMed

    Gholami, Mohammad; Brennan, Robert W

    2016-01-01

    In this paper, we investigate alternative distributed clustering techniques for wireless sensor node tracking in an industrial environment. The research builds on extant work on wireless sensor node clustering by reporting on: (1) the development of a novel distributed management approach for tracking mobile nodes in an industrial wireless sensor network; and (2) an objective comparison of alternative cluster management approaches for wireless sensor networks. To perform this comparison, we focus on two main clustering approaches proposed in the literature: pre-defined clusters and ad hoc clusters. These approaches are compared in the context of their reconfigurability: more specifically, we investigate the trade-off between the cost and the effectiveness of competing strategies aimed at adapting to changes in the sensing environment. To support this work, we introduce three new metrics: a cost/efficiency measure, a performance measure, and a resource consumption measure. The results of our experiments show that ad hoc clusters adapt more readily to changes in the sensing environment, but this higher level of adaptability is at the cost of overall efficiency. PMID:26751447

  1. A Comparison of Alternative Distributed Dynamic Cluster Formation Techniques for Industrial Wireless Sensor Networks

    PubMed Central

    Gholami, Mohammad; Brennan, Robert W.

    2016-01-01

    In this paper, we investigate alternative distributed clustering techniques for wireless sensor node tracking in an industrial environment. The research builds on extant work on wireless sensor node clustering by reporting on: (1) the development of a novel distributed management approach for tracking mobile nodes in an industrial wireless sensor network; and (2) an objective comparison of alternative cluster management approaches for wireless sensor networks. To perform this comparison, we focus on two main clustering approaches proposed in the literature: pre-defined clusters and ad hoc clusters. These approaches are compared in the context of their reconfigurability: more specifically, we investigate the trade-off between the cost and the effectiveness of competing strategies aimed at adapting to changes in the sensing environment. To support this work, we introduce three new metrics: a cost/efficiency measure, a performance measure, and a resource consumption measure. The results of our experiments show that ad hoc clusters adapt more readily to changes in the sensing environment, but this higher level of adaptability is at the cost of overall efficiency. PMID:26751447

  2. Comparison of JSFR design with EDF requirements for future SFR

    SciTech Connect

    Uematsu, M. M.; Prele, G.; Mariteau, P.; Sauvage, J. F.; Hayafune, H.; Chikazawa, Y.

    2012-07-01

    A comparison of Japan sodium-cooled fast reactor (JSFR) design with future French SFR concept has been done based on the requirement of EDF, the investor-operator of future French SFR, and the French safety baseline, under the framework of EDF-JAEA bilateral agreement of research and development cooperation on future SFR. (authors)

  3. Structural optimization of an alternate design for the Space Shuttle solid rocket booster field joint

    NASA Technical Reports Server (NTRS)

    Barthelemy, Jean-Francois M.; Rogers, James L., Jr.; Chang, Kwan J.

    1987-01-01

    A structural optimization procedure is used to determine the shape of an alternate design for the Shuttle's solid rocket booster field joint. In contrast to the tang and clevis design of the existing joint, this alternate design consists of two flanges bolted together. Configurations with 150 studs of 1 1/8 in diameter and 135 studs of 1 3/16 in diameter are considered. Using a nonlinear programming procedure, the joint weight is minimized under constraints on either von Mises or maximum normal stresses, joint opening and geometry. The procedure solves the design problem by replacing it by a sequence of approximate (convex) subproblems; the pattern of contact between the joint halves is determined every few cycles by a nonlinear displacement analysis. The minimum weight design has 135 studs of 1 3/16 in diameter and is designed under constraints on normal stresses. It weighs 1144 lb per joint more than the current tang and clevis design.

  4. Structural optimization of an alternate design for the space shuttle solid rocket booster field joint

    NASA Technical Reports Server (NTRS)

    Barthelemy, J.-F. M.; Chang, K. J.; Rogers, J. L., Jr.

    1987-01-01

    A structural optimization procedure is used to determine the shape of an alternate design for the shuttle solid rocket booster field joint. In contrast to the tang and clevis design of the existing joint, this alternate design consists of two flanges bolted together. Configurations with 150 studs of 1 1/8 in. diameter and 135 studs of 1 3/16 in. diameter are considered. Using a nonlinear programming procedure, the joint weight is minimized under constraints on either von Mises or maximum normal stresses, joint opening and geometry. The procedure solves the design problem by replacing it by a sequence of approximate (convex) subproblems; the pattern of contact between the joint halves is determined every few cycles by a nonliner displacement analysis. The minimum weight design has 135 studs of 1 3/16 in. diameter and is designed under constraints on normal stresses. It weighs 1144 lb per joint more than the current tang and clevis design.

  5. Use of the Alternating Treatment Design to Evaluate Intervention in Low Vision Rehabilitation.

    ERIC Educational Resources Information Center

    LaGrow, S. J.; Murray, S.

    1992-01-01

    This article illustrates use of the alternating treatment design to assess effectiveness of individualized interventions in low vision rehabilitation. The design was used to determine whether enlarging copy (to one of two magnification levels) and adding contrast would be effective in reducing the time a visually impaired student required to read…

  6. Detailed design, fabrication and testing of an engineering prototype compensated pulsed alternator. Final report

    SciTech Connect

    Bird, W.L. Jr.; Woodson, H.H.

    1980-03-01

    The design, fabrication, and test results of a prototype compensated pulsed alternator are discussed. The prototype compulsator is a vertical shaft single phase alternator with a rotating armature and salient pole stator. The machine is designed for low rep rate pulsed duty and is sized to drive a modified 10 cm Beta amplifier. The load consists of sixteen 15 mm x 20 mm x 112 cm long xenon flashlamps connected in parallel. The prototype compulsator generates an open circuit voltage of 6 kV, 180 Hz, at a maximum design speed of 5400 rpm. At maximum speed, the inertial energy stored in the compulsator rotor is 3.4 megajoules.

  7. Total System Performance Assessment- License Appication Design Selection (LADS) Phase 1 Analysis for Post-Closure Ventilation (Design Alternative 3)

    SciTech Connect

    N. Erb

    1999-06-21

    The objective of this report is to evaluate the effect of potential changes to the TSPA-VA base case design on long-term repository performance. The design changes that are evaluated in this report include two configurations for post-closure ventilation. bow tie and open loop (Design Alternative 3 or D3). The following paragraphs briefly describe the motivation for evaluating post-closure ventilation. The bow tie configuration for post closure ventilation has been identified as a design alternative to the TSPA-VA base case model (CRWMS M&O, 1998a) that may provide improved performance by reducing the temperature and relative humidity within the waste package drifts. The bow tie configuration for post-closure ventilation is a closed-loop design. In this design. cross drifts are placed in pairs with each drift angling up on opposite sides of the repository. From the side, the cross drifts and side drifts form the shape of a bow tie. Movement of air through the system is driven by convective heating from the waste packages in the cross drifts. The open loop configuration is also being considered for its potential to improve post-closure performance of the repository. As with the bow tie configuration, the open loop is designed to decrease temperature and relative humidity within the waste package drifts. For the open loop configuration, air is drawn into the drifts from outside the mountain. The configuration for the repository with open-loop ventilation is similar to the base case repository design with a few added shafts to increase air flow through the drifts. This report documents the modeling assumptions and calculations conducted to evaluate the long-term performance of Design Alternative 3. The performance measure for this evaluation is dose rate. Results are presented that compare the dose-rate time histories with the new design alternatives to that for the TSPA-VA base case calculation (CRWMS M&O, 1998a).

  8. Preliminary design of a mini-Brayton Compressor-Alternator-Turbine (CAT)

    NASA Technical Reports Server (NTRS)

    1973-01-01

    The preliminary design of a mini-Brayton compressor-alternator-turbine system is discussed. The program design goals are listed. The optimum system characteristics over the entire range of power output were determined by performing a wide-range parametric study. The ability to develop the required components to the degree necessary within the limitations of present technology is evaluated. The sensitivity of the system to various individual design parameters was analyzed.

  9. Digital-computer program for design analysis of salient, wound pole alternators

    NASA Technical Reports Server (NTRS)

    Repas, D. S.

    1973-01-01

    A digital computer program for analyzing the electromagnetic design of salient, wound pole alternators is presented. The program, which is written in FORTRAN 4, calculates the open-circuit saturation curve, the field-current requirements at rated voltage for various loads and losses, efficiency, reactances, time constants, and weights. The methods used to calculate some of these items are presented or appropriate references are cited. Instructions for using the program and typical program input and output for an alternator design are given, and an alphabetical list of most FORTRAN symbols and the complete program listing with flow charts are included.

  10. Evaluation of HiPHES convective reformer design alternatives. Phase 2, Final issue

    SciTech Connect

    Not Available

    1991-08-01

    Phase I Stone & Webster presented three potential design configurations for a ceramic-tubed steam-methane reformer. These were the Tube-Within-a-Tube (TWIT) design, the Once-Through design, and the Monolith design. Although the TWIT design configuration appeared to be the most viable, the inclusion of a more detailed examination of design alternatives for the HiPHES reformer was deemed appropriate for the Phase II program. Of particular concern was the length of the ceramic tubes required for the TWIT design. To assist in this evaluation, Stone & Webster established a Development Team consisting of specialists in the areas of heat transfer, ceramic materials, exchanger design, vessel design, and potential users. Stone & Webster reviewed the critical areas of concern for a ceramic convective reformer, evaluated competing design configurations, and presented the results to the Development Team. This report presents Stone & Webster`s evaluations and the comments and recommendations of the Development Team. This effort comprised the majority of Task 1 of Phase II of Stone & Webster`s HiPHES project. The design review was executed in parallel with the material coupon screening tests at BP America. The goal of both tasks was to confirm the materials selection and reformer design configuration so that the conditions for the tube and joint tests to be conducted at Oak Ridge National Laboratory (ORNL) could be specified. The ORNL tests are intended to evaluate the reformer design configuration and materials of construction used for the reformer design in Phase II, and to be used in the demonstration unit in Phase III. The Task 1 (Evaluation of Alternative Reformer Designs) effort has identified a preferred design configuration for the proposed ceramic reformer. Additional engineering and material evaluation work is necessary before an operating prototype can be designed.

  11. Cell and stack design alternatives. Final report, August 1, 1978-December 31, 1979

    SciTech Connect

    Hoover, Jr., D. Q.; King, Robert B.

    1980-02-01

    The work described comprised the first phase of a planned six phase program to develop commercially viable phosphoric acid fuel cell (PAFC) driven on-site integrated energy systems (OS/IES). The Phase I effort was organized as three major technical tasks; (1) study of system design alternatives; (2) fuel cell design alternatives; and (3) methane conditioner study. It was decided that comprehensive modeling of one application would most effectively utilize the resources available for the study of systems design alternatives. A 48 unit apartment complex located in Albany, New York and built to HUD minimum standards was selected as being typical of the applications that will be served by the systems. The time varying space conditioning (HVAC) and electrical requirements including the effects of varying weather conditions, living habits and occupancy patterns were modeled. These requirements formed the basis for comparing the performance and cost of the alternative configurations with each other and with a conventional system. Five basic alternative OS/IES configurations plus four variations were selected from a preliminary list of 13 basic configurations for detailed performance nd cost evaluations. Study procedures and results are presented in detail. (WHK)

  12. Identification of alternative splice variants in Aspergillus flavus through comparison of multiple tandem MS search algorithms

    PubMed Central

    2011-01-01

    Background Database searching is the most frequently used approach for automated peptide assignment and protein inference of tandem mass spectra. The results, however, depend on the sequences in target databases and on search algorithms. Recently by using an alternative splicing database, we identified more proteins than with the annotated proteins in Aspergillus flavus. In this study, we aimed at finding a greater number of eligible splice variants based on newly available transcript sequences and the latest genome annotation. The improved database was then used to compare four search algorithms: Mascot, OMSSA, X! Tandem, and InsPecT. Results The updated alternative splicing database predicted 15833 putative protein variants, 61% more than the previous results. There was transcript evidence for 50% of the updated genes compared to the previous 35% coverage. Database searches were conducted using the same set of spectral data, search parameters, and protein database but with different algorithms. The false discovery rates of the peptide-spectrum matches were estimated < 2%. The numbers of the total identified proteins varied from 765 to 867 between algorithms. Whereas 42% (1651/3891) of peptide assignments were unanimous, the comparison showed that 51% (568/1114) of the RefSeq proteins and 15% (11/72) of the putative splice variants were inferred by all algorithms. 12 plausible isoforms were discovered by focusing on the consensus peptides which were detected by at least three different algorithms. The analysis found different conserved domains in two putative isoforms of UDP-galactose 4-epimerase. Conclusions We were able to detect dozens of new peptides using the improved alternative splicing database with the recently updated annotation of the A. flavus genome. Unlike the identifications of the peptides and the RefSeq proteins, large variations existed between the putative splice variants identified by different algorithms. 12 candidates of putative isoforms

  13. Alternate design concept for the SSC dipole magnet cryogenic support post

    SciTech Connect

    Lipski, A.; Nicol, T.H.; Richardson, R.

    1991-03-01

    New materials and developments in the field of advanced composites have created the opportunity to take a fresh look into the design of the cryogenic supports for SSC collider dipole cryostats. Although the present reentrant post design meets the structural and thermal requirements, its assembly requires precision and proficiency. The objective of the proposed alternate concept is to reduce the overall cost of the support post by means of simplifying and optimizing its component design and assembly process. The present shrink fitted tube assembly may potentially be replaced by injection molded parts. New resin systems with lower thermal conductivity and high strength properties enable the utilization of automated production techniques such as injection molding and filament winding. This paper will provide analysis and design information for the alternate support post concept and compare its test performance and cost to the present support post. 3 refs., 12 figs., 4 tabs.

  14. Alternatives generation and analysis for the Phase I intermediate waste feed staging system design requirements

    SciTech Connect

    Claghorn, R.D., Fluor Daniel Hanford

    1997-02-06

    This alternatives generation and analysis (AGA) addresses the question: What is the design basis for the facilities required to stage low-level waste (LLW) feed to the Phase I private contractors? Alternative designs for the intermediate waste feed staging system were developed, analyzed, and compared. Based on these analyses, this document recommends installing mixer pumps in the central pump pit of double-shell tanks 241-AP-102 and 241-AP-104. Also recommended is installing decant/transfer pumps at these tanks. These recommendations have clear advantages in that they provide a low shedule impact/risk and the highest operability of all the alternatives investigated. This revision incorporates comments from the decision board.

  15. Alternative Communication Network Designs for an Operational Plato IV CAI System.

    ERIC Educational Resources Information Center

    Morley, Robert E., Jr.; Eastwood, Lester F., Jr.

    Alternative communication networks for the dissemination of PLATO IV computer aided instruction were designed and comparative cost estimates were made for leased telephone lines, satellite communications, UHF TV, and low-power microwave radio. Costs per student contact hour were computed on the basis of student population density in public schools…

  16. Single-Case Research Design: An Alternative Strategy for Evidence-Based Practice

    ERIC Educational Resources Information Center

    Stapleton, Drue; Hawkins, Andrew

    2015-01-01

    Objective: The trend of utilizing evidence-based practice (EBP) in athletic training is now requiring clinicians, researchers, educators, and students to be equipped to both engage in and make judgments about research evidence. Single-case design (SCD) research may provide an alternative approach to develop such skills and inform clinical and…

  17. What Can We Learn from Chaos Theory? An Alternative Approach to Instructional Systems Design.

    ERIC Educational Resources Information Center

    You, Yeongmahn

    1993-01-01

    Explains chaos theory; compares a conventional instructional systems design (ISD) approach with chaos theory and dynamic nonlinear systems, including deterministic predictability and indeterministic unpredictability and negative and positive feedback; explores theoretical implications for developing an alternative ISD model; and recommends future…

  18. 49 CFR 451.14 - Alternative approval of new containers by design type.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 6 2011-10-01 2011-10-01 false Alternative approval of new containers by design type. 451.14 Section 451.14 Transportation Other Regulations Relating to Transportation (Continued) COAST GUARD, DEPARTMENT OF HOMELAND SECURITY SAFETY APPROVAL OF CARGO CONTAINERS TESTING AND APPROVAL OF CONTAINERS Approval of New Containers §...

  19. Comparison of Alternatives to the 2004 Vacuum Vessel Heat Transfer System

    SciTech Connect

    Yoder Jr, Graydon L; Carbajo, Juan J; Kim, Seokho H

    2010-12-01

    A study comparing different alternatives for the Vacuum Vessel Primary Heat Transfer System has been completed. Three alternatives were proposed in a Project Change Request (PCR-190) by relocating the heat exchangers (HXs) from the roof of the Tokamak building to inside the Vacuum Vessel Pressure Suppression System (VVPSS) tank. The study evaluated the three alternatives and recommended modifications to one of them to arrive at a preferred configuration that included relocating the HXs inside the Tokamak building but outside the VVPSS tank as well as including a small safety-rated pump and HX in parallel to the main circulation pump and HX. The Vacuum Vessel (VV) Primary Heat Transfer System (PHTS) removes heat generated in the VV during normal operation (10 MW, pulsed power) as well as the decay heat from the VV itself and from the structures/components attached to the VV (first wall, blanket, and divertor {approx}0.48 MW peak). Therefore, the VV PHTS has two safety functions: (1) contain contaminated cooling water (similar to the other PHTSs) and (2) provide passive cooling during an accident event. The 2004 design of the VV PHTS consists of two independent loops, each loop cooling half of the 18 VV segments with a nominal flow of 475 kg/s of water at about 1.1 MPa and 100 C. The total flow for both loops is 950 kg/s. Both loops are required to remove the heat load during normal plasma operation. During accident conditions, only one loop is needed to remove by natural convection (no pump needed) the decay heat of the complete VV and attached components. The heat is transferred to heat exchanger (HXs) located on top of the roof, outside the Tokamak building. These HXs are air-to-water (A/W) HXs. Three alternatives have been proposed for this cooling system. For a detailed discussion of these alternatives, please refer to Project Change Request, PCR-190 (Ref. 1). A brief introduction is given here. Alternative 1 includes only one main forced circulation loop with a

  20. Mirror fusion propulsion system: A performance comparison with alternate propulsion systems for the manned Mars Mission

    NASA Technical Reports Server (NTRS)

    Schulze, Norman R.; Carpenter, Scott A.; Deveny, Marc E.; Oconnell, T.

    1993-01-01

    The performance characteristics of several propulsion technologies applied to piloted Mars missions are compared. The characteristics that are compared are Initial Mass in Low Earth Orbit (IMLEO), mission flexibility, and flight times. The propulsion systems being compared are both demonstrated and envisioned: Chemical (or Cryogenic), Nuclear Thermal Rocket (NTR) solid core, NTR gas core, Nuclear Electric Propulsion (NEP), and a mirror fusion space propulsion system. The proposed magnetic mirror fusion reactor, known as the Mirror Fusion Propulsion System (MFPS), is described. The description is an overview of a design study that was conducted to convert a mirror reactor experiment at Lawrence Livermore National Lab (LLNL) into a viable space propulsion system. Design principles geared towards minimizing mass and maximizing power available for thrust are identified and applied to the LLNL reactor design, resulting in the MFPS. The MFPS' design evolution, reactor and fuel choices, and system configuration are described. Results of the performance comparison shows that the MFPS minimizes flight time to 60 to 90 days for flights to Mars while allowing continuous return-home capability while at Mars. Total MFPS IMLEO including propellant and payloads is kept to about 1,000 metric tons.

  1. Mirror fusion propulsion system - A performance comparison with alternate propulsion systems for the manned Mars mission

    NASA Technical Reports Server (NTRS)

    Deveny, M.; Carpenter, S.; O'Connell, T.; Schulze, N.

    1993-01-01

    The performance characteristics of several propulsion technologies applied to piloted Mars missions are compared. The characteristics that are compared are Initial Mass in Low Earth Orbit (IMLEO), mission flexibility, and flight times. The propulsion systems being compared are both demonstrated and envisioned: Chemical (or Cryogenic), Nuclear Thermal Rocket (NTR) solid core, NTR gas core, Nuclear Electric Propulsion (NEP), and a mirror fusion space propulsion system. The proposed magnetic mirror fusion reactor, known as the Mirror Fusion Propulsion System (MFPS), is described. The description is an overview of a design study that was conducted to convert a mirror reactor experiment at Lawrence Livermore National Lab (LLNL) into a viable space propulsion system. Design principles geared towards minimizing mass and maximizing power available for thrust are identified and applied to the LLNL reactor design, resulting in the MFPS. The MFPS' design evolution, reactor and fuel choices, and system configuration are described. Results of the performance comparison shows that the MFPS minimizes flight time to 60 to 90 days for flights to Mars while allowing continuous return-home capability while at Mars. Total MFPS IMLEO including propellant and payloads is kept to about 1,000 metric tons.

  2. Mirror fusion propulsion system: A performance comparison with alternate propulsion systems for the manned Mars Mission

    SciTech Connect

    Schulze, N.R.; Carpenter, S.A.; Deveny, M.E.; Oconnell, T.

    1993-06-01

    The performance characteristics of several propulsion technologies applied to piloted Mars missions are compared. The characteristics that are compared are Initial Mass in Low Earth Orbit (IMLEO), mission flexibility, and flight times. The propulsion systems being compared are both demonstrated and envisioned: Chemical (or Cryogenic), Nuclear Thermal Rocket (NTR) solid core, NTR gas core, Nuclear Electric Propulsion (NEP), and a mirror fusion space propulsion system. The proposed magnetic mirror fusion reactor, known as the Mirror Fusion Propulsion System (MFPS), is described. The description is an overview of a design study that was conducted to convert a mirror reactor experiment at Lawrence Livermore National Lab (LLNL) into a viable space propulsion system. Design principles geared towards minimizing mass and maximizing power available for thrust are identified and applied to the LLNL reactor design, resulting in the MFPS. The MFPS' design evolution, reactor and fuel choices, and system configuration are described. Results of the performance comparison shows that the MFPS minimizes flight time to 60 to 90 days for flights to Mars while allowing continuous return-home capability while at Mars. Total MFPS IMLEO including propellant and payloads is kept to about 1,000 metric tons.

  3. Mirror fusion propulsion system - A performance comparison with alternate propulsion systems for the manned Mars mission

    SciTech Connect

    Deveny, M.; Carpenter, S.; O'connell, T.; Schulze, N.

    1993-06-01

    The performance characteristics of several propulsion technologies applied to piloted Mars missions are compared. The characteristics that are compared are Initial Mass in Low Earth Orbit (IMLEO), mission flexibility, and flight times. The propulsion systems being compared are both demonstrated and envisioned: Chemical (or Cryogenic), Nuclear Thermal Rocket (NTR) solid core, NTR gas core, Nuclear Electric Propulsion (NEP), and a mirror fusion space propulsion system. The proposed magnetic mirror fusion reactor, known as the Mirror Fusion Propulsion System (MFPS), is described. The description is an overview of a design study that was conducted to convert a mirror reactor experiment at Lawrence Livermore National Lab (LLNL) into a viable space propulsion system. Design principles geared towards minimizing mass and maximizing power available for thrust are identified and applied to the LLNL reactor design, resulting in the MFPS. The MFPS' design evolution, reactor and fuel choices, and system configuration are described. Results of the performance comparison shows that the MFPS minimizes flight time to 60 to 90 days for flights to Mars while allowing continuous return-home capability while at Mars. Total MFPS IMLEO including propellant and payloads is kept to about 1,000 metric tons. 50 refs.

  4. 40 CFR 97.417 - Objections concerning designated representative and alternate designated representative.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... NOX AND SO2 TRADING PROGRAMS TR NOX Annual Trading Program § 97.417 Objections concerning designated... designated representative or the finality of any decision or order by the Administrator under the TR NOX... of TR NOX Annual allowance transfers....

  5. 40 CFR 97.417 - Objections concerning designated representative and alternate designated representative.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... NOX AND SO2 TRADING PROGRAMS TR NOX Annual Trading Program § 97.417 Objections concerning designated... designated representative or the finality of any decision or order by the Administrator under the TR NOX... of TR NOX Annual allowance transfers....

  6. 40 CFR 97.417 - Objections concerning designated representative and alternate designated representative.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... NOX AND SO2 TRADING PROGRAMS TR NOX Annual Trading Program § 97.417 Objections concerning designated... designated representative or the finality of any decision or order by the Administrator under the TR NOX... of TR NOX Annual allowance transfers....

  7. Dual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin-converting enzyme inhibition in patients with chronic systolic heart failure: rationale for and design of the Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF)

    PubMed Central

    McMurray, John J. V.; Packer, Milton; Desai, Akshay S.; Gong, Jim; Lefkowitz, Martin P.; Rizkala, Adel R.; Rouleau, Jean; Shi, Victor C.; Solomon, Scott D.; Swedberg, Karl; Zile, Michael R.

    2013-01-01

    Aims Although the focus of therapeutic intervention has been on neurohormonal pathways thought to be harmful in heart failure (HF), such as the renin–angiotensin–aldosterone system (RAAS), potentially beneficial counter-regulatory systems are also active in HF. These promote vasodilatation and natriuresis, inhibit abnormal growth, suppress the RAAS and sympathetic nervous system, and augment parasympathetic activity. The best understood of these mediators are the natriuretic peptides which are metabolized by the enzyme neprilysin. LCZ696 belongs to a new class of drugs, the angiotensin receptor neprilysin inhibitors (ARNIs), which both block the RAAS and augment natriuretic peptides. Methods Patients with chronic HF, NYHA class II–IV symptoms, an elevated plasma BNP or NT-proBNP level, and an LVEF of ≤40% were enrolled in the Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortailty and morbidity in Heart Failure trial (PARADIGM-HF). Patients entered a single-blind enalapril run-in period (titrated to 10 mg b.i.d.), followed by an LCZ696 run-in period (100 mg titrated to 200 mg b.i.d.). A total of 8436 patients tolerating both periods were randomized 1:1 to either enalapril 10 mg b.i.d. or LCZ696 200 mg b.i.d. The primary outcome is the composite of cardiovascular death or HF hospitalization, although the trial is powered to detect a 15% relative risk reduction in cardiovascular death. Perspectives PARADIGM-HF will determine the place of the ARNI LCZ696 as an alternative to enalapril in patients with systolic HF. PARADIGM-HF may change our approach to neurohormonal modulation in HF. Trial registration NCT01035255 PMID:23563576

  8. Mixed land use and obesity: an empirical comparison of alternative land use measures and geographic scales

    PubMed Central

    Yamada, Ikuho; Brown, Barbara B.; Smith, Ken R.; Zick, Cathleen D.; Kowaleski-Jones, Lori; Fan, Jessie X.

    2011-01-01

    Obesity is a growing epidemic in the United States. Walkable neighborhoods, characterized as having the 3Ds of walkability (population Density, land use Diversity, and pedestrian-friendly Design), have been identified as a potentially promising factor to prevent obesity for their residents. Past studies examining the relationship between obesity and walkability vary in geographic scales of neighborhood definitions and methods of measuring the 3Ds. To better understand potential influences of these sometimes arbitrary choices, we test how four types of alternative measures of land use diversity measured at three geographic scales relate to body mass index for 4960 Salt Lake County adults. Generalized estimation equation models demonstrate that optimal diversity measures differed by gender and geographic scale and that integrating walkability measures at different scales improved the overall performance of models. PMID:22665941

  9. Alternatives to Double Hull Tank Vessel Design, Oil Pollution Act of 1990. Report to the Congress

    SciTech Connect

    Not Available

    1992-12-24

    The report required by section 4115(e) of the Oil Pollution Act of 1990. The report concludes that, at present, there are no equivalent designs to the double hull tanker for the prevention of oil outflow due to groundings, which are the most prevalent type of serious vessel accident in U.S. waters. The report does not recommend any changes to the Oil Pollution Act of 1990 to allow alternatives to double hull design, but does recommend that the Coast Guard continue to evaluate novel tanker designs and associated technologies.

  10. Comparison of alternative flue gas dry treatment technologies in waste-to-energy processes.

    PubMed

    Dal Pozzo, Alessandro; Antonioni, Giacomo; Guglielmi, Daniele; Stramigioli, Carlo; Cozzani, Valerio

    2016-05-01

    Acid gases such as HCl and SO2 are harmful both for human health and ecosystem integrity, hence their removal is a key step of the flue gas treatment of Waste-to-Energy (WtE) plants. Methods based on the injection of dry sorbents are among the Best Available Techniques for acid gas removal. In particular, systems based on double reaction and filtration stages represent nowadays an effective technology for emission control. The aim of the present study is the simulation of a reference two-stage (2S) dry treatment system performance and its comparison to three benchmarking alternatives based on single stage sodium bicarbonate injection. A modelling procedure was applied in order to identify the optimal operating configuration of the 2S system for different reference waste compositions, and to determine the total annual cost of operation. Taking into account both operating and capital costs, the 2S system appears the most cost-effective solution for medium to high chlorine content wastes. A Monte Carlo sensitivity analysis was carried out to assess the robustness of the results. PMID:26951719

  11. An alternative parameterization of Bayesian logistic hierarchical models for mixed treatment comparisons.

    PubMed

    Pechlivanoglou, Petros; Abegaz, Fentaw; Postma, Maarten J; Wit, Ernst

    2015-01-01

    Mixed treatment comparison (MTC) models rely on estimates of relative effectiveness from randomized clinical trials so as to respect randomization across treatment arms. This approach could potentially be simplified by an alternative parameterization of the way effectiveness is modeled. We introduce a treatment-based parameterization of the MTC model that estimates outcomes on both the study and treatment levels. We compare the proposed model to the commonly used MTC models using a simulation study as well as three randomized clinical trial datasets from published systematic reviews comparing (i) treatments on bleeding after cirrhosis, (ii) the impact of antihypertensive drugs in diabetes mellitus, and (iii) smoking cessation strategies. The simulation results suggest similar or sometimes better performance of the treatment-based MTC model. Moreover, from the real data analyses, little differences were observed on the inference extracted from both models. Overall, our proposed MTC approach performed as good, or better, than the commonly applied indirect and MTC models and is simpler, fast, and easier to implement in standard statistical software. PMID:25958984

  12. Defect printability of ArF alternative phase-shift mask: a critical comparison of simulation and experiment

    NASA Astrophysics Data System (ADS)

    Ozawa, Ken; Komizo, Tooru; Ohnuma, Hidetoshi

    2002-07-01

    An alternative phase shift mask (alt-PSM) is a promising device for extending optical lithography to finer design rules. There have been few reports, however, on the mask's ability to identify phase defects. We report here an alt-PSM of a single-trench type with undercut for ArF exposure, with programmed phase defects used to evaluate defect printability by measuring aerial images with a Zeiss MSM193 measuring system. The experimental results are simulated using the TEMPEST program. First, a critical comparison of the simulation and the experiment is conducted. The actual measured topographies of quartz defects are used in the simulation. Moreover, a general simulation study on defect printability using an alt-PSM for ArF exposure is conducted. The defect dimensions, which produce critical CD errors, are determined by simulation that takes into account the full 3-dimensional structure of phase defects as well as a simplified structure. The critical dimensions of an isolated bump defect identified by the alt-PSM of a single-trench type with undercut for ArF exposure are 300 nm in bottom dimension and 74 degrees in height (phase) for the real shape, where the depth of wet-etching is 100 nm and the CD error limit is +/- 5 percent.

  13. Comparison of Response Surface and Kriging Models in the Multidisciplinary Design of an Aerospike Nozzle

    NASA Technical Reports Server (NTRS)

    Simpson, Timothy W.

    1998-01-01

    The use of response surface models and kriging models are compared for approximating non-random, deterministic computer analyses. After discussing the traditional response surface approach for constructing polynomial models for approximation, kriging is presented as an alternative statistical-based approximation method for the design and analysis of computer experiments. Both approximation methods are applied to the multidisciplinary design and analysis of an aerospike nozzle which consists of a computational fluid dynamics model and a finite element analysis model. Error analysis of the response surface and kriging models is performed along with a graphical comparison of the approximations. Four optimization problems are formulated and solved using both approximation models. While neither approximation technique consistently outperforms the other in this example, the kriging models using only a constant for the underlying global model and a Gaussian correlation function perform as well as the second order polynomial response surface models.

  14. Comparison of Response Surface and Kriging Models for Multidisciplinary Design Optimization

    NASA Technical Reports Server (NTRS)

    Simpson, Timothy W.; Korte, John J.; Mauery, Timothy M.; Mistree, Farrokh

    1998-01-01

    In this paper, we compare and contrast the use of second-order response surface models and kriging models for approximating non-random, deterministic computer analyses. After reviewing the response surface method for constructing polynomial approximations, kriging is presented as an alternative approximation method for the design and analysis of computer experiments. Both methods are applied to the multidisciplinary design of an aerospike nozzle which consists of a computational fluid dynamics model and a finite-element model. Error analysis of the response surface and kriging models is performed along with a graphical comparison of the approximations, and four optimization problems m formulated and solved using both sets of approximation models. The second-order response surface models and kriging models-using a constant underlying global model and a Gaussian correlation function-yield comparable results.

  15. A Collaborative Alternative Path Program for Career-Changing Mathematics and Science Professionals: Context, Design, and Replication

    ERIC Educational Resources Information Center

    Selke, Mary J.; Fero, George J.

    2005-01-01

    The purpose of this article is to provide insights useful to readers involved in or considering the design and delivery of alternative path programs by presenting (a) a chronology of the multiple definitions of alternative certification, (b) key components of quality alternative path programs, viewed through the example of a program for…

  16. Comparison of alternative treatment systems for DOE mixed low-level waste

    SciTech Connect

    Schwinkendorf, W.E.

    1997-03-01

    From 1993 to 1996, the Department of Energy, Environmental Management, Office of Science and Technology (OST), has sponsored a series of systems analyses to guide its future research and development (R&D) programs for the treatment of mixed low-level waste (MLLW) stored in the DOE complex. The two original studies were of 20 mature and innovative thermal systems. As a result of a technical review of these thermal system studies, a similar study of five innovative nonthermal systems was conducted in which unit operations are limited to temperatures less than 350{degrees}C to minimize volatilization of heavy metals and radionuclides, and de novo production of dioxins and furans in the offgas. Public involvement in the INTS study was established through a working group of 20 tribal and stakeholder representatives to provide input to the INTS studies and identify principles against which the systems should be designed and evaluated. Pre-conceptual designs were developed for all systems to treat the same waste input (2927 lbs/hr) in a single centralized facility operating 4032 hours per year for 20 years. This inventory consisted of a wide range of combustible and non-combustible materials such as paper, plastics, metals, concrete, soils, sludges, liquids, etc., contaminated with trace quantities of radioactive materials and RCRA regulated wastes. From this inventory, an average waste profile was developed for simulated treatment using ASPEN PLUS{copyright} for mass balance calculations. Seven representative thermal systems were selected for comparison with the five nonthermal systems. This report presents the comparisons against the TSWG principles, of total life cycle cost (TLCC), and of other system performance indicators such as energy requirements, reagent requirements, land use, final waste volume, aqueous and gaseous effluents, etc.

  17. Knowledge engineering: An alternative approach to curriculum design for science education at a distance

    NASA Astrophysics Data System (ADS)

    Jegede, Olugbemiro J.; Taylor, James C.; Okebukola, Peter Akinsola

    1991-12-01

    Most of the curriculum design models within the technical-scientific approach utilise the rational and sequential process of designing and inter-relating the various elements of the design process. While this procedure may be efficient and adequate for conventional education in which the designers are professional science educators, there is doubt if it satisfies the particular needs of distance education. The experience accumulated through a multi-disciplinary team approach to distance learning courseware development for higher education at the University of Southern Queensland Distance Education Centre motivated this study which primarily focused on a search for an alternative approach to curriculum development with a more satisfactory functional value. Using selected units in Engineering as a focus, an experiment was designed in which a variant of the classical Wheeler model was used. This paper reports the results of this experiment. The implications for contemporary curriculum development initiatives in science especially within distance education settings are pointed out.

  18. Performance of R-410A Alternative Refrigerants in a Reciprocating Compressor Designed for Air Conditioning Applications

    SciTech Connect

    Shrestha, Som S; Vineyard, Edward Allan; Mumpower, Kevin

    2016-01-01

    In response to environmental concerns raised by the use of refrigerants with high Global Warming Potential (GWP), the Air-Conditioning, Heating, and Refrigeration Institute (AHRI) has launched an industry-wide cooperative research program, referred to as the Low-GWP Alternative Refrigerants Evaluation Program (AREP), to identify and evaluate promising alternative refrigerants for major product categories. After successfully completing the first phase of the program in December 2013, AHRI launched a second phase of the Low-GWP AREP in 2014 to continue research in areas that were not previously addressed, including refrigerants in high ambient conditions, refrigerants in applications not tested in the first phase, and new refrigerants identified since testing for the program began. Although the Ozone Depletion Potential of R-410A is zero, this refrigerant is under scrutiny due to its high GWP. Several candidate alternative refrigerants have already demonstrated low global warming potential. Performance of these low-GWP alternative refrigerants is being evaluated for Air conditioning and heat pump applications to ensure acceptable system capacity and efficiency. This paper reports the results of a series of compressor calorimeter tests conducted for the second phase of the AREP to evaluate the performance of R-410A alternative refrigerants in a reciprocating compressor designed for air conditioning systems. It compares performance of alternative refrigerants ARM-71A, L41-1, DR-5A, D2Y-60, and R-32 to that of R-410A over a wide range of operating conditions. The tests showed that, in general, cooling capacities were slightly lower (except for the R-32), but energy efficiency ratios (EER) of the alternative refrigerants were comparable to that of R-410A.

  19. 40 CFR 97.614 - Responsibilities of designated representative and alternate designated representative.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... NOX AND SO2 TRADING PROGRAMS TR SO2 Group 1 Trading Program § 97.614 Responsibilities of designated... delegation of authority to make submissions, each submission under the TR SO2 Group 1 Trading Program shall... representative for each TR SO2 Group 1 source and TR SO2 Group 1 unit for which the submission is made. Each...

  20. 40 CFR 97.414 - Responsibilities of designated representative and alternate designated representative.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... NOX AND SO2 TRADING PROGRAMS TR NOX Annual Trading Program § 97.414 Responsibilities of designated... delegation of authority to make submissions, each submission under the TR NOX Annual Trading Program shall be... each TR NOX Annual source and TR NOX Annual unit for which the submission is made. Each such...

  1. 40 CFR 97.517 - Objections concerning designated representative and alternate designated representative.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... NOX AND SO2 TRADING PROGRAMS TR NOX Ozone Season Trading Program § 97.517 Objections concerning... designated representative or the finality of any decision or order by the Administrator under the TR NOX... of TR NOX Ozone Season allowance transfers....

  2. 40 CFR 97.517 - Objections concerning designated representative and alternate designated representative.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... NOX AND SO2 TRADING PROGRAMS TR NOX Ozone Season Trading Program § 97.517 Objections concerning... designated representative or the finality of any decision or order by the Administrator under the TR NOX... of TR NOX Ozone Season allowance transfers....

  3. 40 CFR 97.414 - Responsibilities of designated representative and alternate designated representative.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... NOX AND SO2 TRADING PROGRAMS TR NOX Annual Trading Program § 97.414 Responsibilities of designated... delegation of authority to make submissions, each submission under the TR NOX Annual Trading Program shall be... each TR NOX Annual source and TR NOX Annual unit for which the submission is made. Each such...

  4. 40 CFR 97.614 - Responsibilities of designated representative and alternate designated representative.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... NOX AND SO2 TRADING PROGRAMS TR SO2 Group 1 Trading Program § 97.614 Responsibilities of designated... delegation of authority to make submissions, each submission under the TR SO2 Group 1 Trading Program shall... representative for each TR SO2 Group 1 source and TR SO2 Group 1 unit for which the submission is made. Each...

  5. 40 CFR 97.517 - Objections concerning designated representative and alternate designated representative.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... NOX AND SO2 TRADING PROGRAMS TR NOX Ozone Season Trading Program § 97.517 Objections concerning... designated representative or the finality of any decision or order by the Administrator under the TR NOX... of TR NOX Ozone Season allowance transfers....

  6. 40 CFR 97.414 - Responsibilities of designated representative and alternate designated representative.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... NOX AND SO2 TRADING PROGRAMS TR NOX Annual Trading Program § 97.414 Responsibilities of designated... delegation of authority to make submissions, each submission under the TR NOX Annual Trading Program shall be... each TR NOX Annual source and TR NOX Annual unit for which the submission is made. Each such...

  7. 40 CFR 97.614 - Responsibilities of designated representative and alternate designated representative.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... NOX AND SO2 TRADING PROGRAMS TR SO2 Group 1 Trading Program § 97.614 Responsibilities of designated... delegation of authority to make submissions, each submission under the TR SO2 Group 1 Trading Program shall... representative for each TR SO2 Group 1 source and TR SO2 Group 1 unit for which the submission is made. Each...

  8. Alternative routes for highway shipments of radioactive materials and lessons learned from state designations

    SciTech Connect

    Not Available

    1990-07-01

    Pursuant to the Hazardous Materials Transportation Act (HMTA), the Department of Transportation (DOT) has promulgated a comprehensive set of regulations regarding the highway transportation of high-level radioactive materials. These regulations, under docket numbers HM-164 and HM-164A, establish interstate highways as the preferred routes for the transportation of radioactive materials within and through the states. The regulations also provide a methodology by which a state may select altemative routes. First, the state must establish a ``state routing agency``, defined as an entity authorized to use the state legal process to impose routing requirements on carriers of radioactive material (49 CFR 171.8). Once identified, the state routing agency must select routes in accordance with DOTs Guidelines for Selecting Preferred Highway Routes for Large Quantity Shipments of Radioactive Materials or an equivalent routing analysis. Adjoining states and localities should be consulted on the impact of proposed alternative routes as a prerequisite of final route selection. Lastly, the states must provide written notice to DOT of any alternative route designation before the routes are deemed effective. The purpose of this report is to discuss the ``lessons learned`` by the five states within the southern region that have designated alternative or preferred routes under the regulations of the Department of Transportation (DOT) established for the transportation of radioactive materials. The document was prepared by reviewing applicable federal laws and regulations, examining state reports and documents and contacting state officials and routing agencies involved in making routing decisions. In undertaking this project, the Southern States Energy Board hopes to reveal the process used by states that have designated alternative routes and thereby share their experiences (i.e., lessons learned) with other southern states that have yet to make designations.

  9. Alternative routes for highway shipments of radioactive materials and lessons learned from state designations

    SciTech Connect

    Not Available

    1990-07-01

    Pursuant to the Hazardous Materials Transportation Act (HMTA), the Department of Transportation (DOT) has promulgated a comprehensive set of regulations regarding the highway transportation of high-level radioactive materials. These regulations, under docket numbers HM-164 and HM-164A, establish interstate highways as the preferred routes for the transportation of radioactive materials within and through the states. The regulations also provide a methodology by which a state may select altemative routes. First, the state must establish a state routing agency'', defined as an entity authorized to use the state legal process to impose routing requirements on carriers of radioactive material (49 CFR 171.8). Once identified, the state routing agency must select routes in accordance with DOTs Guidelines for Selecting Preferred Highway Routes for Large Quantity Shipments of Radioactive Materials or an equivalent routing analysis. Adjoining states and localities should be consulted on the impact of proposed alternative routes as a prerequisite of final route selection. Lastly, the states must provide written notice to DOT of any alternative route designation before the routes are deemed effective. The purpose of this report is to discuss the lessons learned'' by the five states within the southern region that have designated alternative or preferred routes under the regulations of the Department of Transportation (DOT) established for the transportation of radioactive materials. The document was prepared by reviewing applicable federal laws and regulations, examining state reports and documents and contacting state officials and routing agencies involved in making routing decisions. In undertaking this project, the Southern States Energy Board hopes to reveal the process used by states that have designated alternative routes and thereby share their experiences (i.e., lessons learned) with other southern states that have yet to make designations.

  10. Surveillance of Aedes aegypti: Comparison of House Index with Four Alternative Traps

    PubMed Central

    Codeço, Claudia T.; Lima, Arthur W. S.; Araújo, Simone C.; Lima, José Bento P.; Maciel-de-Freitas, Rafael; Honório, Nildimar A.; Galardo, Allan K. R.; Braga, Ima A.; Coelho, Giovanini E.; Valle, Denise

    2015-01-01

    Introduction The mosquito Aedes aegypti, vector of dengue, chikungunya and yellow fever viruses, is an important target of vector control programs in tropical countries. Most mosquito surveillance programs are still based on the traditional household larval surveys, despite the availability of new trapping devices. We report the results of a multicentric entomological survey using four types of traps, besides the larval survey, to compare the entomological indices generated by these different surveillance tools in terms of their sensitivity to detect mosquito density variation. Methods The study was conducted in five mid-sized cities, representing variations of tropical climate regimens. Surveillance schemes using traps for adults (BG-Sentinel, Adultrap and MosquiTRAP) or eggs (ovitraps) were applied monthly to three 1 km2 areas per city. Simultaneously, larval surveys were performed. Trap positivity and density indices in each area were calculated and regressed against meteorological variables to characterize the seasonal pattern of mosquito infestation in all cities, as measured by each of the four traps. Results The House Index was consistently low in most cities, with median always 0. Traps rarely produced null indices, pointing to their greater sensitivity in detecting the presence of Ae. aegypti in comparison to the larval survey. Trap positivity indices tend to plateau at high mosquito densities. Despite this, both indices, positivity and density, agreed on the seasonality of mosquito abundance in all cities. Mosquito seasonality associated preferentially with temperature than with precipitation even in areas where temperature variation is small. Conclusions All investigated traps performed better than the House Index in measuring the seasonal variation in mosquito abundance and should be considered as complements or alternatives to larval surveys. Choice between traps should further consider differences of cost and ease-of-use. PMID:25668559

  11. A Comparison of Candidate Seal Designs for Future Docking Systems

    NASA Technical Reports Server (NTRS)

    Dunlap, Patrick, H., Jr.; Steinetz, Bruce, M.

    2012-01-01

    NASA is developing a new docking system to support future space exploration missions to low Earth orbit, the Moon, and other destinations. A key component of this system is the seal at the main docking interface which inhibits the loss of cabin air once docking is complete. Depending on the mission, the seal must be able to dock in either a seal-on-flange or seal-on-seal configuration. Seal-on-flange mating would occur when a docking system equipped with a seal docks to a system with a flat metal flange. This would occur when a vehicle docks to a node on the International Space Station. Seal-on-seal mating would occur when two docking systems equipped with seals dock to each other. Two types of seal designs were identified for this application: Gask-O-seals and multi-piece seals. Both types of seals had a pair of seal bulbs to satisfy the redundancy requirement. A series of performance assessments and comparisons were made between the candidate seal designs indicating that they meet the requirements for leak rate and compression and adhesion loads under a range of operating conditions. Other design factors such as part count, integration into the docking system tunnel, seal-on-seal mating, and cost were also considered leading to the selection of the multi-piece seal design for the new docking system. The results of this study can be used by designers of future docking systems and other habitable volumes to select the seal design best-suited for their particular application.

  12. DOE/ORNL heat pump design model, overview and application to R-22 alternatives

    SciTech Connect

    Rice, C.K.

    1997-12-01

    This computer program is a public-domain system design tool for application to air-to-air heat pumps. The main aspects of the program are reviewed with emphasis on the newest features of the current fifth-generation version (Mark V) and an upcoming more fully HFC-capable release (Mark VI). Current model predictions are compared to test data for a leading HFC alternative to HCFC-22 in heat pumps. Examples are shown of some user interfaces that have been recently developed for the program. To demonstrate the design capabilities of the model for R-22 alternatives, a refrigerant-side optimization was conducted to find the best balance of heat transfer versus pressure drop for HCFC R-22, HFCs R-134a and R-410A, and the natural refrigerant propane. COP was maximized while refrigerant charge and tube size were minimized. Independent design parameters were fraction of total area in the outdoor coil, tube diameter and number of circuits for each heat exchanger, and condenser subcooling. Heat exchanger design tradeoffs are discussed for a heat pump relative to air conditioners and heating-only units. A design optimized for heating-only operation is presented.

  13. Alternative design of inductive pointing device for oral interface for computers and wheelchairs.

    PubMed

    Lontis, Eugen R; Andreasen Struijk, Lotte N S

    2012-01-01

    An inductive pointing device was designed and implemented successfully in a tongue controlled oral interface. Sensors were manufactured as an assembly of multilayer coils in the printed circuit board technology on two pads. The sensor pads were encapsulated together with electronics and battery in a mouthpiece, placed in the upper palate of the oral cavity. The PCB technology allowed surface activation of one or more sensors by gliding over the surface of the coils assembly of a small cylindrical unit attached to the tongue. The model consisted of 8 sensors and allowed real time proportional control of both speed and direction similar to a joystick. However, the size of the oral cavity, the number and geometry of the coil loops and characteristics of the activation unit impose limits in designing the sensors and call for an alternative layout design. Two alternative sensor designs are proposed in this paper, aiming to reduce the size of the sensor pad by one third, extending the target group, including children, and increasing the easiness of wear of the oral interface. PMID:23366638

  14. Characterizing cryogenic propellant flow behavior through a cavitating venturi in comparison to alternative flow control mechanisms

    NASA Astrophysics Data System (ADS)

    Ingle, Marjorie Adele

    The work detailed is an investigation of the use of a cavitating venturi as both a flow control and metering device. This was achieved through the combination of actual experimentation and numerical modeling of the fluid behavior of both liquid water and liquid methane as it passes through the test article designed, developed, and validated here within this study. The discharge coefficient of the cavitating venturi was determined through weigh flow calibration testing to determine an average mass flow rate. Turbine flow meter flow rate readings were used as a point of comparison and the discharge coefficient was computed. The discharge coefficient was then implemented into the Bernoulli Equation along with experimental pressure and temperature data to again calculate mass flow rate through the cavitating venturi. The agreement of the venturi flow rate data to that of the turbine flow meter effectively established its applicability as a passive flow control and metering feature. A preliminary CFD cavitation model was developed and validated for cavitating water flow regimes using ANSYS FLUENT. Agreement between mass flow rates obtained from the model to experimental data for cavitating water flow indicates that deviations in results for liquid methane analysis from experimental results could simply be the result of insufficiently defined fluid characteristics in the ANSYS FLUENT materials database. SEM surface roughness analysis of a secondary test article indicated that the default average surface roughness for steel in ANSYS FLUENT was reasonable. In addition, the methodology could be further applied to future duty life studies for the cavitating venturi flow meter.

  15. Clinical outcome research in complementary and alternative medicine: an overview of experimental design and analysis.

    PubMed

    Gatchel, R J; Maddrey, A M

    1998-09-01

    This article serves as a primer for those beginning clinical research in complementary and alternative medicine. The authors provide a basic overview of important experimental design and statistical issues, of which clinical researchers in the area of complementary and alternative medicine must be aware when attempting to demonstrate the effectiveness of particular treatment modalities. As the article suggests, science is an inferential process, and experimental investigations can vary greatly in methodological integrity. Key concepts in clinical outcome research such as internal validity, statistical conclusion validity, and the appropriate measurement and operational definitions of outcomes are discussed. New scientific approaches that are evolving because of paradigm shifts in science (e.g., chaos theory) are also reviewed. Suggestions are provided to further develop an understanding of clinical outcome research methodology. PMID:9737030

  16. Alternative communication network designs for an operational Plato 4 CAI system

    NASA Technical Reports Server (NTRS)

    Mobley, R. E., Jr.; Eastwood, L. F., Jr.

    1975-01-01

    The cost of alternative communications networks for the dissemination of PLATO IV computer-aided instruction (CAI) was studied. Four communication techniques are compared: leased telephone lines, satellite communication, UHF TV, and low-power microwave radio. For each network design, costs per student contact hour are computed. These costs are derived as functions of student population density, a parameter which can be calculated from census data for one potential market for CAI, the public primary and secondary schools. Calculating costs in this way allows one to determine which of the four communications alternatives can serve this market least expensively for any given area in the U.S. The analysis indicates that radio distribution techniques are cost optimum over a wide range of conditions.

  17. Exploration of alternate catalytic mechanisms and optimization strategies for retroaldolase design.

    PubMed

    Bjelic, Sinisa; Kipnis, Yakov; Wang, Ling; Pianowski, Zbigniew; Vorobiev, Sergey; Su, Min; Seetharaman, Jayaraman; Xiao, Rong; Kornhaber, Gregory; Hunt, John F; Tong, Liang; Hilvert, Donald; Baker, David

    2014-01-01

    Designed retroaldolases have utilized a nucleophilic lysine to promote carbon-carbon bond cleavage of β-hydroxy-ketones via a covalent Schiff base intermediate. Previous computational designs have incorporated a water molecule to facilitate formation and breakdown of the carbinolamine intermediate to give the Schiff base and to function as a general acid/base. Here we investigate an alternative active-site design in which the catalytic water molecule was replaced by the side chain of a glutamic acid. Five out of seven designs expressed solubly and exhibited catalytic efficiencies similar to previously designed retroaldolases for the conversion of 4-hydroxy-4-(6-methoxy-2-naphthyl)-2-butanone to 6-methoxy-2-naphthaldehyde and acetone. After one round of site-directed saturation mutagenesis, improved variants of the two best designs, RA114 and RA117, exhibited among the highest kcat (>10(-3)s(-1)) and kcat/KM (11-25M(-1)s(-1)) values observed for retroaldolase designs prior to comprehensive directed evolution. In both cases, the >10(5)-fold rate accelerations that were achieved are within 1-3 orders of magnitude of the rate enhancements reported for the best catalysts for related reactions, including catalytic antibodies (kcat/kuncat=10(6) to 10(8)) and an extensively evolved computational design (kcat/kuncat>10(7)). The catalytic sites, revealed by X-ray structures of optimized versions of the two active designs, are in close agreement with the design models except for the catalytic lysine in RA114. We further improved the variants by computational remodeling of the loops and yeast display selection for reactivity of the catalytic lysine with a diketone probe, obtaining an additional order of magnitude enhancement in activity with both approaches. PMID:24161950

  18. Exploration of Alternate Catalytic Mechanisms and Optimization Strategies for Retroaldolase Design

    PubMed Central

    Bjelic, Sinisa; Kipnis, Yakov; Wang, Ling; Pianowski, Zbigniew; Vorobiev, Sergey; Su, Min; Seetharaman, Jayaraman; Xiao, Rong; Kornhaber, Gregory; Hunt, John F.; Tong, Liang; Hilvert, Donald; Baker, David

    2014-01-01

    Designed retroaldolases have utilized a nucleophilic lysine to promote carbon–carbon bond cleavage of β-hydroxy-ketones via a covalent Schiff base intermediate. Previous computational designs have incorporated a water molecule to facilitate formation and breakdown of the carbinolamine intermediate to give the Schiff base and to function as a general acid/base. Here we investigate an alternative active-site design in which the catalytic water molecule was replaced by the side chain of a glutamic acid. Five out of seven designs expressed solubly and exhibited catalytic efficiencies similar to previously designed retroaldolases for the conversion of 4-hydro-xy-4-(6-methoxy-2-naphthyl)-2-butanone to 6-methoxy-2-naphthaldehyde and acetone. After one round of site-directed saturation mutagenesis, improved variants of the two best designs, RA114 and RA117, exhibited among the highest kcat (>10−3 s−1) and kcat/KM (11–25 M−1 s−1) values observed for retroaldolase designs prior to comprehensive directed evolution. In both cases, the >105-fold rate accelerations that were achieved are within 1–3 orders of magnitude of the rate enhancements reported for the best catalysts for related reactions, including catalytic antibodies (kcat/kuncat = 106 to 108) and an extensively evolved computational design (kcat/kuncat > 107). The catalytic sites, revealed by X-ray structures of optimized versions of the two active designs, are in close agreement with the design models except for the catalytic lysine in RA114. We further improved the variants by computational remodeling of the loops and yeast display selection for reactivity of the catalytic lysine with a diketone probe, obtaining an additional order of magnitude enhancement in activity with both approaches. PMID:24161950

  19. Comparison of Explicit Forgiveness Interventions with an Alternative Treatment: A Randomized Clinical Trial

    ERIC Educational Resources Information Center

    Wade, Nathaniel G.; Worthington, Everett L.; Haake, Shawn

    2009-01-01

    Forgiveness interventions can help people forgive past offenses. However, few studies have compared forgiveness interventions with genuine alternative treatments. The authors compared forgiveness interventions with a therapeutic alternative treatment. Participants reduced unforgiveness and increased forgiveness regardless of treatment condition.…

  20. A Comparison of Student Academic Achievement between Alternatively and Traditionally Certified Teachers

    ERIC Educational Resources Information Center

    Stephens, Mary W.

    2007-01-01

    This research study evaluated the achievement of students who were taught by traditionally certified teachers with students who were taught by alternatively certified teachers or those seeking certification through an alternative certification program. The primary purpose of the study was to examine significant differences, if any, in student…

  1. Comparison of coil designs for peripheral magnetic muscle stimulation.

    PubMed

    Goetz, S M; Herzog, H-G; Gattinger, N; Gleich, B

    2011-10-01

    The recent application of magnetic stimulation in rehabilitation is often said to solve key drawbacks of the established electrical method. Magnetic fields cause less pain, allow principally a better penetration of inhomogeneous biologic tissue and do not require skin contact. However, in most studies the evoked muscle force has been disappointing. In this paper, a comparison of a classical round circular geometry, a commercial muscle-stimulation coil and a novel design is presented, with special emphasis on the physical field properties. These systems show markedly different force responses for the same magnetic energy and highlight the enormous potential of different coil geometries. The new design resulted in a slope of the force recruiting curve being more than two and a half times higher than the other coils. The data were analyzed with respect to the underlying physical causes and field conditions. After a parameter-extraction approach, the results for the three coils span a two-dimensional space with clearly distinguishable degrees of freedom, which can be manipulated nearly separately and reflect the two main features of a field; the peak amplitude and its decay with the distance. PMID:21832812

  2. Alternative Ultrasound Gel for a Sustainable Ultrasound Program: Application of Human Centered Design

    PubMed Central

    Bissinger, Alexa; Muller, Mundenga Mutendi; Gebreyesus, Alegnta; Geremew, Haimanot; Wendell, Sarah; Azaza, Aklilu; Salumu, Maurice; Benfield, Nerys

    2015-01-01

    This paper describes design of a low cost, ultrasound gel from local products applying aspects of Human Centered Design methodology. A multidisciplinary team worked with clinicians who use ultrasound where commercial gel is cost prohibitive and scarce. The team followed the format outlined in the Ideo Took Kit. Research began by defining the challenge "how to create locally available alternative ultrasound gel for a low-resourced environment? The "End-Users," were identified as clinicians who use ultrasound in Democratic Republic of the Congo and Ethiopia. An expert group was identified and queried for possible alternatives to commercial gel. Responses included shampoo, oils, water and cornstarch. Cornstarch, while a reasonable solution, was either not available or too expensive. We then sought deeper knowledge of locally sources materials from local experts, market vendors, to develop a similar product. Suggested solutions gleaned from these interviews were collected and used to create ultrasound gel accounting for cost, image quality, manufacturing capability. Initial prototypes used cassava root flour from Great Lakes Region (DRC, Rwanda, Uganda, Tanzania) and West Africa, and bula from Ethiopia. Prototypes were tested in the field and resulting images evaluated by our user group. A final prototype was then selected. Cassava and bula at a 32 part water, 8 part flour and 4 part salt, heated, mixed then cooled was the product design of choice. PMID:26252003

  3. Alternative Ultrasound Gel for a Sustainable Ultrasound Program: Application of Human Centered Design.

    PubMed

    Salmon, Margaret; Salmon, Christian; Bissinger, Alexa; Muller, Mundenga Mutendi; Gebreyesus, Alegnta; Geremew, Haimanot; Wendel, Sarah K; Wendell, Sarah; Azaza, Aklilu; Salumu, Maurice; Benfield, Nerys

    2015-01-01

    This paper describes design of a low cost, ultrasound gel from local products applying aspects of Human Centered Design methodology. A multidisciplinary team worked with clinicians who use ultrasound where commercial gel is cost prohibitive and scarce. The team followed the format outlined in the Ideo Took Kit. Research began by defining the challenge "how to create locally available alternative ultrasound gel for a low-resourced environment? The "End-Users," were identified as clinicians who use ultrasound in Democratic Republic of the Congo and Ethiopia. An expert group was identified and queried for possible alternatives to commercial gel. Responses included shampoo, oils, water and cornstarch. Cornstarch, while a reasonable solution, was either not available or too expensive. We then sought deeper knowledge of locally sources materials from local experts, market vendors, to develop a similar product. Suggested solutions gleaned from these interviews were collected and used to create ultrasound gel accounting for cost, image quality, manufacturing capability. Initial prototypes used cassava root flour from Great Lakes Region (DRC, Rwanda, Uganda, Tanzania) and West Africa, and bula from Ethiopia. Prototypes were tested in the field and resulting images evaluated by our user group. A final prototype was then selected. Cassava and bula at a 32 part water, 8 part flour and 4 part salt, heated, mixed then cooled was the product design of choice. PMID:26252003

  4. Interdigital H -mode drift-tube linac design with alternative phase focusing for muon linac

    NASA Astrophysics Data System (ADS)

    Otani, M.; Mibe, T.; Yoshida, M.; Hasegawa, K.; Kondo, Y.; Hayashizaki, N.; Iwashita, Y.; Iwata, Y.; Kitamura, R.; Saito, N.

    2016-04-01

    We have developed an interdigital H-mode (IH) drift-tube linac (DTL) design with an alternative phase focusing (APF) scheme for a muon linac, in order to measure the anomalous magnetic moment and electric dipole moment (EDM) of muons at the Japan Proton Accelerator Research Complex (J-PARC). The IH-DTL accelerates muons from β =v /c =0.08 to 0.28 at an operational frequency of 324 MHz. The output beam emittances are calculated as 0.315 π and 0.195 π mm mrad in the horizontal and vertical directions, respectively, which satisfies the experimental requirement.

  5. Environmental and economic comparisons of the satellite power system and six alternative energy technologies

    NASA Astrophysics Data System (ADS)

    Whitfield, R. G.; Habegger, L. J.; Levine, E. P.; Tanzman, E.

    1981-04-01

    The satellite power system (SPS) was compared with alternative systems on life cycle cost and environmental impacts. Environmental and economic effects are evaluated and subdivided into the following issue areas: human health and safety, environmental welfare, resources (land, materials, energy, water, labor), macroeconomics, socioeconomics, and institutional. These evaluations are based on technology characterization data and alternative futures scenarios, developed as part of CDEP. The technologies and the scenarios are described. The cost and performance of the SPS and the alternative technologies provide the basis of the macroeconomic analyses.

  6. A comparative study of Soviet versus Western helicopters. Part 1: General comparison of designs

    NASA Technical Reports Server (NTRS)

    Stepniewski, W. Z.

    1983-01-01

    This document provides a general comparison of the state of the art of Soviet helicopter design vs. that of the West (U.S. in particular). It includes both commonalities and differences in conceptual design philosophies by addressing design parameters and design effectiveness according to accepted criteria. The baseline for comparison is by design gross weight which is presented in four categories: under 12,000 lb, 30-100,000 lb, and greater than 100,000 lb.

  7. Preliminary design study of an alternate heat source assembly for a Brayton isotope power system

    NASA Technical Reports Server (NTRS)

    Strumpf, H. J.

    1978-01-01

    Results are presented for a study of the preliminary design of an alternate heat source assembly (HSA) intended for use in the Brayton isotope power system (BIPS). The BIPS converts thermal energy emitted by a radioactive heat source into electrical energy by means of a closed Brayton cycle. A heat source heat exchanger configuration was selected and optimized. The design consists of a 10 turn helically wound Hastelloy X tube. Thermal analyses were performed for various operating conditions to ensure that post impact containment shell (PICS) temperatures remain within specified limits. These limits are essentially satisfied for all modes of operation except for the emergency cooling system for which the PICS temperatures are too high. Neon was found to be the best choice for a fill gas for auxiliary cooling system operation. Low cycle fatigue life, natural frequency, and dynamic loading requirements can be met with minor modifications to the existing HSA.

  8. A better alternative to stratified permuted block design for subject randomization in clinical trials.

    PubMed

    Zhao, Wenle

    2014-12-30

    Stratified permuted block randomization has been the dominant covariate-adaptive randomization procedure in clinical trials for several decades. Its high probability of deterministic assignment and low capacity of covariate balancing have been well recognized. The popularity of this sub-optimal method is largely due to its simplicity in implementation and the lack of better alternatives. Proposed in this paper is a two-stage covariate-adaptive randomization procedure that uses the block urn design or the big stick design in stage one to restrict the treatment imbalance within each covariate stratum, and uses the biased-coin minimization method in stage two to control imbalances in the distribution of additional covariates that are not included in the stratification algorithm. Analytical and simulation results show that the new randomization procedure significantly reduces the probability of deterministic assignments, and improve the covariate balancing capacity when compared to the traditional stratified permuted block randomization. PMID:25043719

  9. A demonstration of motion base design alternatives for the National Advanced Driving Simulator

    NASA Technical Reports Server (NTRS)

    Mccauley, Michael E.; Sharkey, Thomas J.; Sinacori, John B.; Laforce, Soren; Miller, James C.; Cook, Anthony

    1992-01-01

    A demonstration of the capability of NASA's Vertical Motion Simulator to simulate two alternative motion base designs for the National Advanced Driving simulator (NADS) is reported. The VMS is located at ARC. The motion base conditions used in this demonstration were as follows: (1) a large translational motion base; and (2) a motion base design with limited translational capability. The latter had translational capability representative of a typical synergistic motion platform. These alternatives were selected to test the prediction that large amplitude translational motion would result in a lower incidence or severity of simulator induced sickness (SIS) than would a limited translational motion base. A total of 10 drivers performed two tasks, slaloms and quick-stops, using each of the motion bases. Physiological, objective, and subjective measures were collected. No reliable differences in SIS between the motion base conditions was found in this demonstration. However, in light of the cost considerations and engineering challenges associated with implementing a large translation motion base, performance of a formal study is recommended.

  10. A Visual Analytics Based Decision Support Methodology For Evaluating Low Energy Building Design Alternatives

    NASA Astrophysics Data System (ADS)

    Dutta, Ranojoy

    The ability to design high performance buildings has acquired great importance in recent years due to numerous federal, societal and environmental initiatives. However, this endeavor is much more demanding in terms of designer expertise and time. It requires a whole new level of synergy between automated performance prediction with the human capabilities to perceive, evaluate and ultimately select a suitable solution. While performance prediction can be highly automated through the use of computers, performance evaluation cannot, unless it is with respect to a single criterion. The need to address multi-criteria requirements makes it more valuable for a designer to know the "latitude" or "degrees of freedom" he has in changing certain design variables while achieving preset criteria such as energy performance, life cycle cost, environmental impacts etc. This requirement can be met by a decision support framework based on near-optimal "satisficing" as opposed to purely optimal decision making techniques. Currently, such a comprehensive design framework is lacking, which is the basis for undertaking this research. The primary objective of this research is to facilitate a complementary relationship between designers and computers for Multi-Criterion Decision Making (MCDM) during high performance building design. It is based on the application of Monte Carlo approaches to create a database of solutions using deterministic whole building energy simulations, along with data mining methods to rank variable importance and reduce the multi-dimensionality of the problem. A novel interactive visualization approach is then proposed which uses regression based models to create dynamic interplays of how varying these important variables affect the multiple criteria, while providing a visual range or band of variation of the different design parameters. The MCDM process has been incorporated into an alternative methodology for high performance building design referred to as

  11. Model‐Based Assessment of Alternative Study Designs in Pediatric Trials. Part II: Bayesian Approaches

    PubMed Central

    Smania, G; Baiardi, P; Ceci, A; Magni, P

    2016-01-01

    This study presents a pharmacokinetic‐pharmacodynamic based clinical trial simulation framework for evaluating the performance of a fixed‐sample Bayesian design (BD) and two alternative Bayesian sequential designs (BSDs) (i.e., a non‐hierarchical (NON‐H) and a semi‐hierarchical (SEMI‐H) one). Prior information was elicited from adult trials and weighted based on the expected similarity of response to treatment between the pediatric and adult populations. Study designs were evaluated in terms of: type I and II errors, sample size per arm (SS), trial duration (TD), and estimate precision. No substantial differences were observed between NON‐H and SEMI‐H. BSDs require, on average, smaller SS and TD compared to the BD, which, on the other hand, guarantees higher estimate precision. When large differences between children and adults are expected, BSDs can return very large SS. Bayesian approaches appear to outperform their frequentist counterparts in the design of pediatric trials even when little weight is given to prior information from adults. PMID:27530374

  12. Survey of alternative gas turbine engine and cycle design. Final report

    SciTech Connect

    Lukas, H.

    1986-02-01

    In the period of the 1940's to 1960's much experimentation was performed in the areas of intercooling, reheat, and recuperation, as well as the use of low-grade fuels in gas turbines. The Electric Power Research Institute (EPRI), in an effort to document past experience which can be used as the basis for current design activities, commissioned a study to document alternate cycles and components used in gas turbine design. The study was performed by obtaining the important technical and operational criteria of the cycles through a literature search of published documents, articles, and papers. Where possible the information was augmented through dialogue with persons associated with those cycles and with the manufacturers. The survey indicated that many different variations of the simple open-cycle gas turbine plant were used. Many of these changes resulted in increases in efficiency over the low simple-cycle efficiency of that period. Metallurgy, as well as compressor and turbine design, limited the simple-cycle efficiency to the upper teens. The cycle modifications increased those efficiencies to the twenties and thirties. Advances in metallurgy as well as compressor and turbine design, coupled with the decrease in flue cost, stopped the development of these complex cycles. Many of the plants operated successfully for many years, and only because newer simple-cycle gas turbine plants and large steam plants had better heat rates were these units shutdown or put into stand-by service. 24 refs., 25 figs., 114 tabs.

  13. Lithography alternatives meet design style reality: How do they "line" up?

    NASA Astrophysics Data System (ADS)

    Smayling, Michael C.

    2016-03-01

    Optical lithography resolution scaling has stalled, giving innovative alternatives a window of opportunity. One important factor that impacts these lithographic approaches is the transition in design style from 2D to 1D for advanced CMOS logic. Just as the transition from 3D circuits to 2D fabrication 50 years ago created an opportunity for a new breed of electronics companies, the transition today presents exciting and challenging time for lithographers. Today, we are looking at a range of non-optical lithography processes. Those considered here can be broadly categorized: self-aligned lithography, self-assembled lithography, deposition lithography, nano-imprint lithography, pixelated e-beam lithography, shot-based e-beam lithography .Do any of these alternatives benefit from or take advantage of 1D layout? Yes, for example SAPD + CL (Self Aligned Pitch Division combined with Complementary Lithography). This is a widely adopted process for CMOS nodes at 22nm and below. Can there be additional design / process co-optimization? In spite of the simple-looking nature of 1D layout, the placement of "cut" in the lines and "holes" for interlayer connections can be tuned for a given process capability. Examples of such optimization have been presented at this conference, typically showing a reduction of at least one in the number of cut or hole patterns needed.[1,2] Can any of the alternatives complement each other or optical lithography? Yes.[3] For example, DSA (Directed Self Assembly) combines optical lithography with self-assembly. CEBL (Complementary e-Beam Lithography) combines optical lithography with SAPD for lines with shot-based e-beam lithography for cuts and holes. Does one (shrinking) size fit all? No, that's why we have many alternatives. For example NIL (Nano-imprint Lithography) has been introduced for NAND Flash patterning where the (trending lower) defectivity is acceptable for the product. Deposition lithography has been introduced in 3D NAND Flash to

  14. Management of radioactive waste gases from the nuclear fuel cycle. Volume I. Comparison of alternatives

    SciTech Connect

    Evans, A.G.; Prout, W.E.; Buckner, J.T.; Buckner, M.R.

    1980-12-01

    Alternatives were compared for collection and fixation of radioactive waste gases released during normal operation of the nuclear fuel cycle, and for transportation and storage/disposal of the resulting waste forms. The study used a numerical rating scheme to evaluate and compare the alternatives for krypton-85, iodine-129, and carbon-14; whereas a subjective evaluation, based on published reports and engineering judgement, was made for transportation and storage/disposal options. Based on these evaluations, certain alternatives are recommended for an integrated scheme for waste management of each of the subject waste gases. Phase II of this project, which is concerned with the development of performance criteria for the waste forms associated with the subject gases, will be completed by the end of 1980. This work will be documented as Volume II of this report.

  15. Randomized controlled trials in schizophrenia: opportunities, limitations, and trial design alternatives.

    PubMed

    Correll, Christoph U; Kishimoto, Taishiro; Kane, John M

    2011-01-01

    State-of-the art clinical trial design and methodology are enormously important for the advancement of the field. In contrast, the critical relevance of trial conduct and implementation have only more recently been the focus of discussion and research. Although randomized controlled trials are generally considered the gold standard for the assessment of pharmacologic and nonpharmacologic interventions in medicine, trials are vulnerable to complications and influences that can seriously compromise their success. Like interventions, trial design and conduct are also contextual. They need to be individualized and adapted to a number of relevant variables, such as setting, population, illness phase, interventions, patient and rater expectations and biases, and the overall aims of the investigation. While this means that there is no unified approach possible, certain general principles and guidelines require careful consideration. Knowledge of basic solutions and alternatives, and the recognition of the complex challenges that need to be addressed proactively can help to minimize unwanted outcomes, including trial failure and uninformative or falsely negative outcomes. Moreover, novel design alternatives need to be explored that target sample enrichment according to the study question and enhancement of precision in the measurement of relevant outcomes. We propose two novel design strategies that take advantage of the recently validated early antipsychotic response paradigm (that has also been observed with antidepressants and mood stabilizers). In the "early responder randomized discontinuation design" all patients are assigned to the active drug, and only those who had at least a minimal response at 2 weeks are enrolled in a double-blind, placebo-controlled discontinuation trial, enriching the placebo controlled trial portion with true drug responders. In the mirror image "early nonresponder randomized dose increase or augmentation design," early nonresponders at 2

  16. Screening and comparison of remedial alternatives for the South Field and flyash piles at the Fernald site

    SciTech Connect

    Bumb, A.C.; Jones, G.N.; Warner, R.D.

    1996-05-01

    The South Field, the Inactive Flyash Pile, and the Active Flyash Pile are in close proximity to each other and are part of Operable Unit 2 (OU2) at the Fernald Environmental Management Project (FEMP). The baseline risk assessment indicated that the exposure pathways which pose the most significant risk are external radiation from radionuclides in surface soils and use of uranium contaminated groundwater. This paper presents screening and comparison of various remedial alternatives considered to mitigate risks from the groundwater pathway. Eight remedial alternatives were developed which consisted of consolidation and capping, excavation and off-site disposal with or without treatment, excavation and on-site disposal with or without treatment and combinations of these. Risk-based source (soil) preliminary remediation levels (PRLs) and waste acceptance criteria (WACs) were developed for consolidation and capping, excavation, and on-site disposal cell. The PRLs and WACs were developed using an integrated modeling tool consisting of an infiltration model, a surface water model, a vadose zone model, and a three-dimensional contaminant migration model in saturated media. The PRLs and WACs were then used to determine need for soil treatment, determine excavation volumes, and screen remedial alternatives. The selected remedial alternative consisted of excavation and on-site disposal with off-site disposal of the fraction exceeding the WAC.

  17. Randomized controlled trials and neuro-oncology: should alternative designs be considered?

    PubMed

    Mansouri, Alireza; Shin, Samuel; Cooper, Benjamin; Srivastava, Archita; Bhandari, Mohit; Kondziolka, Douglas

    2015-09-01

    quality of design/reporting of RCTs in neuro-oncology persist. Quality improvement is necessary. Consideration of alternative strategies should be considered. PMID:26297044

  18. RIP Input From WAPDEG for LA Desgin Selection: Enhanced Design Alternative II

    SciTech Connect

    B.E. Bullard

    1999-07-16

    The purpose of this analysis is to identify and analyze concepts for the acquisition of data in support of the Performance Confirmation (PC) program at the potential subsurface nuclear waste repository at Yucca Mountain. This analysis is being prepared to document an investigation of design concepts, current available technology, technology trends, and technical issues associated with data acquisition during the PC period. This analysis utilizes the ''Performance Confirmation Plan'' (CRWMS M&O 2000b) to help define the scope for the PC data acquisition system. The focus of this analysis is primarily on the PC period for a minimum of 30 years after emplacement of the last waste package. The design of the data acquisition system shall allow for a closure deferral up to 300 years from initiation of waste emplacement. (CRWMS M&O 2000h, page 5-1). This analysis is a revision to and supercedes analysis, ''Performance Confirmation Data Acquisition System'', DI No. BCAI00000-017 17-0200-00002 Rev 00 (CRWMS M&O 1997), and incorporates the latest repository design changes following the M&O & DOE evaluation of a series of Enhanced Design Alternatives (EDAs), as described in the ''Enhanced Design Alternatives II Report'' (CRWMS M&O 1999d). Significant design changes include: thermal line loading of the emplacement drifts, closer spacing of the waste packages (WPs), wider spacing and fewer emplacement drifts, continuous ventilation of all active emplacement drifts, thinner walled WP designs which will increase external radiation levels, a 50-year repository closure option, inclusion of a drip-shield, exclusion of backfill, and new conceptual designs for the waste emplacement vehicles and equipment (Stroupe 2000). The scope and primary objectives of this analysis are to: (1) Review the criteria for design as presented in the Performance Confirmation Data Acquisition/Monitoring System Description Document, by way of the Input Transmittal, ''Performance Confirmation Input Criteria

  19. A Comparison of Dense-to-Lean and Fixed Lean Schedules of Alternative Reinforcement and Extinction

    ERIC Educational Resources Information Center

    Hagopian, Louis P.; Toole, Lisa M.; Long, Ethan S.; Bowman, Lynn G.; Lieving, Gregory A.

    2004-01-01

    Behavior-reduction interventions typically employ dense schedules of alternative reinforcement in conjunction with operant extinction for problem behavior. After problem behavior is reduced in the initial treatment stages, schedule thinning is routinely conducted to make the intervention more practical in natural environments. In the current…

  20. Table or Circles: A Comparison of Two Methods for Choosing among Career Alternatives

    ERIC Educational Resources Information Center

    Amit, Adi; Gati, Itamar

    2013-01-01

    A sample of 182 young adults about to choose their college major were randomly assigned to 2 guidance methods aimed at facilitating choosing among promising career alternatives: Table-for-Choice and Circles-for-Choice. Table-for-Choice was perceived as more effective, but individuals' confidence in their choice was higher in the Circles-for-Choice…

  1. A Comparison of Technology Experiences Included in Alternative and Traditional Teacher Education Programs

    ERIC Educational Resources Information Center

    Strycker, Jesse D.

    2011-01-01

    Though an educational technology experience is required as part of a traditional teacher education program student's educational preparation, research has been limited into the experiences had by alternative teacher education program students. Similarly, little research has been done comparing technology experiences between both types of teacher…

  2. Comparison of Traditional and Alternative Fitness Teaching Formats on Heart Rate Intensity and Perceived Enjoyment.

    ERIC Educational Resources Information Center

    Ha, Amy Sau-ching; Heung-Sang Wong, Stephen

    2002-01-01

    Compared a traditional and an alternative (skill-fitness- music) fitness teaching format to determine whether there would be differences on Hong Kong middle school students' heart rate intensity and perceived enjoyment. Data from heart rate monitors and student surveys indicated that the two formats did not produce differences in heart rates.…

  3. Comparison of Alternate and Original Items on the Montreal Cognitive Assessment

    PubMed Central

    Lebedeva, Elena; Huang, Mei; Koski, Lisa

    2016-01-01

    Background The Montreal Cognitive Assessment (MoCA) is a screening tool for mild cognitive impairment (MCI) in elderly individuals. We hypothesized that measurement error when using the new alternate MoCA versions to monitor change over time could be related to the use of items that are not of comparable difficulty to their corresponding originals of similar content. The objective of this study was to compare the difficulty of the alternate MoCA items to the original ones. Methods Five selected items from alternate versions of the MoCA were included with items from the original MoCA administered adaptively to geriatric outpatients (N = 78). Rasch analysis was used to estimate the difficulty level of the items. Results None of the five items from the alternate versions matched the difficulty level of their corresponding original items. Conclusions This study demonstrates the potential benefits of a Rasch analysis-based approach for selecting items during the process of development of parallel forms. The results suggest that better match of the items from different MoCA forms by their difficulty would result in higher sensitivity to changes in cognitive function over time. PMID:27076861

  4. A Comparison of the Professional Concerns of Traditionally Prepared and Alternatively Licensed New Teachers

    ERIC Educational Resources Information Center

    Wayman, Jeffrey C.; Foster, Ann M.; Mantle-Bromley, Corinne; Wilson, Carol Ann

    2003-01-01

    In large urban school districts across the country, shortages of teachers who are qualified for and interested in working in critical content areas are reality. Alternative licensing routes, broadly defined as licensure programs not requiring traditional university teacher preparation work, are increasing in number and a variety of structures.…

  5. A Comparison of the Alternative and Traditional Licensure Programs at Metropolitan State College of Denver.

    ERIC Educational Resources Information Center

    Heyman, Ernest L.

    This study evaluated Metropolitan State College of Denver's Teacher-in-Residence (TiR) alternative licensure program. To participate, teacher candidates must possess a baccalaureate degree, have a teaching contract in a participating local school district, enroll in the TiR program, and pass a state content test. This study examined what Metro…

  6. Overview On Alternate Asbestos Control Method Research And NESHAP Comparison - Nashville, TN

    EPA Science Inventory

    The alternative asbestos control method (AACM) is an experimental approach to building demolition. Unlike the NESHAP method, the AACM allows some regulated asbestos containing material to remain in the building and a surfactant-water solution is used to suppress asbestos fibers ...

  7. Teaching Efficacy: A Comparison of Traditionally and Alternatively Certified CTE Teachers in Idaho

    ERIC Educational Resources Information Center

    Duncan, Dennis W.; Cannon, John; Kitchel, Allen

    2013-01-01

    The purpose of this study was to examine Idaho career and technical education (CTE) teachers' perceived levels of efficacy as related to the domain of teaching and learning, both for traditionally and alternatively certified teachers with 10 or less years of teaching experience. Efficacy was examined for early to mid-career CTE teachers…

  8. Total Program Efficacy: A Comparison of Traditionally and Alternatively Certified Agriculture Teachers

    ERIC Educational Resources Information Center

    Duncan, Dennis W.; Ricketts, John C.

    2008-01-01

    The purpose of this study was to determine agriculture teachers' perceived levels of efficacy as they relate to managing the total program of agricultural education, both for traditionally and alternatively certified teachers. The constructs used in this study were technical content, FFA/leadership development/SAE, teaching and learning, and…

  9. Comparison of Health-Risk Behaviors among Students Attending Alternative and Traditional High Schools in Minnesota

    ERIC Educational Resources Information Center

    Johnson, Karen E.; McMorris, Barbara J.; Kubik, Martha Y.

    2013-01-01

    Previous research, over a decade old, suggests students attending alternative high schools (AHS) engage in high levels of health-risk behaviors. Data from the 2007 Minnesota Student Survey for students attending AHS ("n" = 2,847) and traditional high schools (THS; "n" = 87,468) were used for this cross-sectional analysis to…

  10. Randomized controlled trials in schizophrenia: opportunities, limitations, and trial design alternatives

    PubMed Central

    Correll, Christoph U.; Kishimoto, Taishiro; Kane, John M.

    2011-01-01

    State-of-the art clinical trial design and methodology are enormously important for the advancement of the field. In contrast, the critical relevance of trial conduct and implementation have only more recently been the focus of discussion and research. Although randomized controlled trials are generally considered the gold standard for the assessment of pharmacologic and nonpharmacologic interventions in medicine, trials are vulnerable to complications and influences that can seriously compromise their success, Like interventions, trial design and conduct are also contextual. They need to be individualized and adapted to a number of relevant variables, such as setting, population, illness phase, interventions, patient and rater expectations and biases, and the overall aims of the investigation. While this means that there is no unified approach possible, certain general principles and guidelines require careful consideration. Knowledge of basic solutions and alternatives, and the recognition of the complex challenges that need to be addressed proactively can help to minimize unwanted outcomes, including trial failure and uninformative or falsely negative outcomes. Moreover, novel design alternatives need to be explored that target sample enrichment according to the study question and enhancement of precision in the measurement of relevant outcomes. We propose two novel design strategies that take advantage of the recently validated early antipsychotic response paradigm (that has also been observed with antidepressants and mood stabilizers). In the “early responder randomized discontinuation design” all patients are assigned to the active drug, and only those who had at least a minimal response at 2 weeks are enrolled in a double-blind, placebo-controlled discontinuation trial, enriching the placebo controlled trial portion with true drug responders. In the mirror image “early nonresponder randomized dose increase or augmentation design,” early nonresponders