Sample records for anatomy project nci

  1. Working Group Rosters: NCI Concise Informed Consent Template Project

    Cancer.gov

    Page of 6Working Group Rosters: NCI Concise Informed Consent Template Project Role Working Group 1 (Beginning of template – background, required tests, intervention sections) Working Group 2 (Risks and benefits sections) Working Group 3 (Alternatives,

  2. Cancer Genome Anatomy Project

    NSDL National Science Digital Library

    The National Cancer Institute has launched the Cancer Genome Anatomy Project to "achieve a comprehensive molecular characterization of normal, precancerous, and malignant cells." Sequenced genes are held as library entries in a database and are available for downloading (fasta format). Each cDNA library entry may include biological source, number of sequences, and library construction detail information. Thousands of gene sequences are available for over 15 cancers, including breast, colon, and prostrate. Contact information for donating or obtaining tissue samples for research purposes is provided.

  3. NCI DTP Discovery Services

    Cancer.gov

    What's New Home Discovery Development Pathways Grants/Contracts Books/Publications Site Search Data Search What's New New NCI60 data release MicroXeno Project data now available NCI-60 characterization NCI Experimental Therapeutics Program (NExT)

  4. NCI Organization

    Cancer.gov

    As the nation's leading federal agency for cancer research, NCI has 30 divisions, offices, and centers who work together to build, maintain, and enhance a cohesive and comprehensive cancer research agenda.

  5. Using Independent Research Projects to Foster Learning in the Comparative Vertebrate Anatomy Laboratory

    ERIC Educational Resources Information Center

    Ghedotti, Michael J.; Fielitz, Christopher; Leonard, Daniel J.

    2005-01-01

    This paper presents a teaching methodology involving an independent research project component for use in undergraduate Comparative Vertebrate Anatomy laboratory courses. The proposed project introduces cooperative, active learning in a research context to comparative vertebrate anatomy. This project involves pairs or groups of three students…

  6. NCI Workshop

    Cancer.gov

    NCI Workshop Advanced Technologies for Breast Cancer Radiation of Intact Breast Excellent LOCAL CONTROL (95 % at 5 years) achieved with standard dose 50 Gy Whole Breast plus boost to primary site NO NEED to Dose Escalate OARs: Skin, Lung, Heart (Left

  7. NCI Grants Management

    Cancer.gov

    The Office of Grants Administration (OGA) is the principal office at NCI  that manages all NCI business-related activities associated with the negotiation, award, and administration of NCI grants and cooperative agreements to help financially support

  8. NCI's Cancer Information Service

    MedlinePLUS

    ... and personalized answers. Who Should Use the NCI Contact Center NCI's Contact Center can help you whether ... are of interest. Tell Others About the NCI Contact Center Web Tiles To use one of the ...

  9. NCI Mouse Repository - Information

    Cancer.gov

    General Information About the NCI Mouse Repository Pricing Ordering Information Ordering Live Mice Ordering Cryoarchived Strains Health Reports Getting Assistance / Reporting a Problem Submitting Strains to the NCI Mouse Repository Material Transfer

  10. NCI Designated Cancer Centers

    MedlinePLUS

    ... United States. Find a center near you and learn about its patient services and research capabilities. Most ... this video on YouTube. Partners in Advancing Research Learn how the NCI and its NCI-Designated Cancer ...

  11. NCI DEA - Grant Policies

    Cancer.gov

    In FY 2011, NCI will not publish an RPG payline. Rather, individual consideration of a broad range of applications will be the hallmark of NCI’s selection process for all competing applications. Peer review evaluation of scientific merit will remain the primary consideration in these funding decisions, which will be made by NCI Scientific Program Leaders (SPL) following discussions with Program Staff.

  12. NCI: SBIR & STTR - About - Employment Opportunities

    Cancer.gov

    The National Cancer Institute (NCI) Small Business Innovation Research (SBIR) Development Center manages more than $115 million in small business projects to accelerate the progress of cancer research and care.

  13. NCI DEA - NCI Notices Related to Initiatives

    Cancer.gov

    National Institutes of Health, National Cancer Institute, Division of Extramural Activities - Home Page Skip to Main Content Home Funding Advisory Consumer Guides FAQs & Glossary Awarded Research Division of Extramural Activities NCI Notices Related

  14. Humanities in Gross Anatomy Project: A Novel Humanistic Learning Tool at Des Moines University

    NSDL National Science Digital Library

    Craig Canby (College of Osteopathic Medicine, Des Moines University Anatomy)

    2010-02-08

    This article describes the development of a Humanities in Gross Anatomy Project (HuGA) course for physical therapy students. The purpose of the course is to have physical therapy students reflect on the humanistic side of cadaver donation. Curriculum and outcomes of course are described.

  15. Audio-Tutorial Project: An Audio-Tutorial Approach to Human Anatomy and Physiology.

    ERIC Educational Resources Information Center

    Muzio, Joseph N.; And Others

    A two course sequence on human anatomy and physiology using the audiotutorial method of instruction was developed for use by nursing students and other students in the health or medical fields at the Kingsborough Community College in New York. The project was motivated by the problems of often underprepared students coming to learn a new field and…

  16. Strategic Planning - NCI OSPA Website

    Cancer.gov

    OSPA guides the NCI Divisions, Offices, and Centers (DOCs) in developing goals and strategies that will collectively help NCI achieve its vision. OSPA begins this process by educating NCI staff about the purpose, value, and process of strategic panning.

  17. NCI Interactive Budget Analysis Tool

    Cancer.gov

    This tool provides users an interactive overview of the National Cancer Institute (NCI) budget and Fact Book data since Fiscal Year 1999. Additional historical NCI budget information can be obtained through the NCI Fact Book Collection.

  18. NCI-MATCH

    Cancer.gov

    The NCI-Molecular Analysis for Therapy Choice (NCI-MATCH) trial is a clinical trial that will analyze patients’ tumors to determine whether they contain genetic abnormalities upon which a drug could have an effect (termed “actionable mutations”) and assign treatment based on which abnormality is present.

  19. CDC and NCI Recommendations

    E-print Network

    Appendix A CDC and NCI Responses to Key NAS Recommendations The National Academy of Sciences Committee to Review the CDC-NCI Feasibility Study of the Health Consequences from Nuclear Weapon Test was asked by CDC to address the following specific questions: 1. Are the methods and sources of information

  20. NCI GeoViewer Data

    Cancer.gov

    Skip to Main Content at the National Institutes of Health | www.cancer.gov Search: Submit Home Overview About GIS GIS at NCI GIS Resources GIS Special Interest Group NCI GIS Portal Overview NCI Geoviewer NCI Map Stories Animated Historical Cancer

  1. NCI DEA - Cleared Concepts

    Cancer.gov

    Specific information on each initiative, including receipt date, will be available once the Request for Applications (RFAs) or Program Announcements (PAs) has been published. This page provides links to recent concepts cleared for upcoming solicitations and presents key information, including the objectives and descriptions of future solicitations and a direct link to NCI staff contacts. The NCI staff contacts can provide additional information on specific concepts, where available and appropriate.

  2. Reference -NCI Best Case Series-OCCAM

    Cancer.gov

    Contact Us | Sitemap CAM at the NCI NCI CAM History Highlights of NCI CAM Activities NCI CAM Annual Report Research Funding Opportunities Grant Application Information Research Resources Funded Research Research Results Training Opportunities FAQ's

  3. CAM Research Sponsored by NCI-OCCAM

    Cancer.gov

    Contact Us | Sitemap CAM at the NCI NCI CAM History Highlights of NCI CAM Activities NCI CAM Annual Report Research Funding Opportunities Grant Application Information Research Resources Funded Research Research Results Training Opportunities FAQ's

  4. nci-2007-fact-book

    Cancer.gov

    Former Directors of the NCI.......................................................... O-2 National Cancer Advisory Board................................................... O-3 Boards of Scientific Counselors and Advisors .............................. O-7 President's Cancer Panel ............................................................. O-8 Executive Committee Members .................................................... O-8 NCI Director’s Consumer Liaison Group.

  5. NCI DTP Books and Publications

    Cancer.gov

    Books and Publications Home Discovery Development Pathways Grants/Contracts Books/Publications Site Search Data Search What's New NCI Investigational Drugs - Chemical Information NCI Investigational Drugs - Pharmaceutical Information

  6. NCI Interactive Budget Analysis Tool

    Cancer.gov

    skip to content Home Financial Data Cancer Statistics Contribute About OBF Financial Data Budget Formulation & Justification Plan & Budget Proposal Congressional Justification Congressional Appropriations Documents Historical Spending NCI Fact Book NCI

  7. CISNET: NCI Bulletin Articles

    Cancer.gov

    The NCI Cancer Bulletin is an award-winning biweekly online newsletter designed to provide useful, timely information about cancer research to the cancer community. The material is entirely in the public domain and can be repurposed or reproduced without permission. Citation of the source is appreciated.

  8. Previous NCI Directors

    Cancer.gov

    Since Congress established the National Cancer Institute Act in 1937, the National Cancer Institute has had 14 directors. Douglas Lowy, M.D. is the current Acting Director of the NCI.  Name Entered Office Departed Office Harold E. Varmus July 12,

  9. NCI Best Practices

    Cancer.gov

    This informational publication issued by the NCI OBBR is designed to increase awareness and understanding among advocates and the interested public of the importance and role of biospecimens in cancer research. It outlines the need for and purpose of best practices for biospecimen resources.

  10. NCI DTP Disclaimer

    Cancer.gov

    The U.S. Government, NIH, NCI and their employees and contractors do not make any warranty, express or implied, including the warranties of merchantability and fitness for a particular purpose with respect to documents and data available from this server.

  11. NCI Mobile Apps

    Cancer.gov

    Quit Pal App NCI QuitPal is a free smartphone app to support smokers working to become smoke-free. This interactive app is developed using proven quit strategies and tools to help change behavior and assist you with giving up smoking.

  12. DTP - NCI Investigational Drugs

    Cancer.gov

    This edition of NCI Investigational Drugs - Chemical Information is designed to provide those involved in various phases of drug development with chemical and physical data on compounds which are past or current development candidates in the Developmental Therapeutics Program, Division of Cancer Treatment Diagnosis and Centers, National Cancer Institute. These range from agents which have only just entered the development pipeline to those which are available commercially.

  13. nci-2008-fact-book

    Cancer.gov

    Former Directors of the NCI.......................................................... O-2 National Cancer Advisory Board.................................................O-3A National Cancer Advisory Board, Continued................................O-3B Boards of Scientific Counselors and Advisors .............................. O-7 President's Cancer Panel ............................................................. O-8 Executive Committee Members .................................................... O-8 NCI Director’s Consumer Liaison Group.

  14. About OSPA - NCI OSPA Website

    Cancer.gov

    The Office of Science Planning and Assessment (OSPA), as part of NCI's Office of the Director, is primarily responsible for the development and coordination of NCI's strategic planning and evaluation activities. OSPA carries out its mission through the activities of interconnected groups.

  15. NCI Mouse Repository- Protocol Information

    Cancer.gov

    ICR-Tg(GFAP-CDK4)2Gtm/Nci PCR Protocol Strain: ICR-Tg(GFAP-CDK4)2Gtm/Nci Strain Code: 01XK1 Protocol Number: 1 Introductory Comment: The primer set was taken from the following published paper: Oncogene 21:1325-1334. The primer set amplifies the GFAP

  16. NCI CCT K Awards Evaluation

    Cancer.gov

    NCI’s career development (K) awards program provides support for early-career scientists and clinicians  to develop independent careers in cancer research.  A recent evaluation of the K awards program administered by NCI’s Center for Cancer Training tracked

  17. Humanities in Gross Anatomy Project: A Novel Humanistic Learning Tool at Des Moines University

    ERIC Educational Resources Information Center

    Canby, Craig A.; Bush, Traci A.

    2010-01-01

    Gross anatomy affords physical therapy students an opportunity to discover human morphology by intimately studying the dead. Moreover, it also exposes future physical therapists to the humanistic aspects of the profession. In 2007, anatomy faculty decided to socialize students to the humanities with a new course requirement: Humanities in Gross…

  18. The LINDSAY Virtual Human Project: An immersive Approach to Anatomy and Physiology

    ERIC Educational Resources Information Center

    Tworek, Janet K.; Jamniczky, Heather A.; Jacob, Christian; Hallgrímsson, Benedikt; Wright, Bruce

    2013-01-01

    The increasing number of digital anatomy teaching software packages challenges anatomy educators on how to best integrate these tools for teaching and learning. Realistically, there exists a complex interplay of design, implementation, politics, and learning needs in the development and integration of software for education, each of which may be…

  19. NCI DEA - NCI Grant Guidelines and Descriptions

    Cancer.gov

    NIH Director's New Innovator Awards The DP2 NIH Director’s New Innovator Awards provide support to highly innovative research projects by new investigators in all areas of biomedical and behavioral research.

  20. nci-2011-fact-book

    Cancer.gov

    Fiscal Year 2011 Annual Report ......................................................iii Director's Biography .................................................................... O-1 Former Directors of the NCI......................................................... O-2 National Cancer Advisory Board.................................................. O-4 Boards of Scientific Counselors and Advisors.............................. O-8 President's Cancer Panel ............................................................ O-9 Scientific Program Leaders.

  1. NCI DEA - NCRA Meeting Information

    Cancer.gov

    National Institutes of Health, National Cancer Institute, Division of Extramural Activities - Home Page Skip to Main Content Home Funding Advisory Consumer Guides FAQs & Glossary Awarded Research Division of Extramural Activities NCI Council of Research

  2. NCI Mouse Repository - Ordering Information

    Cancer.gov

    STRAIN UNAVAILABLE FOR ORDERING The HB-PLAP(A to G) strain is currently unavailable for ordering. Top of Page | NCI Mouse Repository | Emice Website | Privacy | Disclaimer Available Strains | Newly Accepted Strains | General Info & Help | Frequently

  3. NCI Interactive Budget Analysis Tool

    Cancer.gov

    Supports planning for new programs, expansion or modification of existing resources, and feasibility studies to explore various approaches to the development of interdisciplinary programs that offer potential solutions to problems of special significance to the mission of the NCI.

  4. NCI Visuals Online: My Pictures

    Cancer.gov

    Skip Navigation NCI Visuals Online Home About My Pictures Browse Search Quick Search My Pictures My Pictures is a place to temporarily store images during your current Visuals Online session. My Pictures currently has no images. Home | About/Contact

  5. NCI Mouse Repository- Protocol Information

    Cancer.gov

    B6;129S-Nkx3-1tm4(cre/ERT2)Mms/Nci PCR Protocol Strain: B6;129S-Nkx3-1tm4(cre/ERT2)Mms/Nci Strain Code: 01XBQ Protocol Number: 1 Introductory Comment: The primers used are to detect the Nkx.3 mutation under CreERT2 control. Primers:  BQ1 :   5'-AAC

  6. NCI Mouse Repository- Protocol Information

    Cancer.gov

    B6;129-Dmtf1tm1Cjs/Nci PCR Protocol Strain: B6;129-Dmtf1tm1Cjs/Nci Strain Code: 01XH1 Protocol Number: 1 Introductory Comment: Primers:  D001 :   5'-GAT GGT ccA ccA TTT AcT TcG -3'  D003 :   5'-GcT GTA GcT GAA AGA GTG GGT Ac -3'  D002 :   5'-AGT ATc

  7. NCI Mouse Repository- Protocol Information

    Cancer.gov

    STOCK Col1a1tm1(CAG-EGFR)Char/Nci PCR Protocol Strain: STOCK Col1a1tm1(CAG-EGFR)Char/Nci Strain Code: 01X67 Protocol Number: 1 Introductory Comment: Primers:  67C1 :   5'-GCA CAG CAT TGC GGA CAT GC -3'  67C3 :   5'-GCA GAA GCG CGG CCG TCT GG -3'  67C2

  8. NCI Shady Grove Shuttle Schedule

    Cancer.gov

    National Cancer Institute Shady Grove Metro Shuttle Schedule NCI Shady Grove Shady Grove Metro Departure NCI SG Departure SGM -- 6:00 AM -- 6:15 AM 6:15 AM 6:30 AM 6:30 AM 6:45 AM 6:45 AM 7:00 AM 7:00 AM 7:15 AM 7:15 AM 7:30 AM 7:30 AM 7:45

  9. Anatomy & Physiology

    MedlinePLUS

    Search SEER Training: SEER Training Modules Print Home Glossary Citation Help Home » Cancer Registration & Surveillance Modules » Anatomy & Physiology Cancer Registration & Surveillance Modules Anatomy & Physiology Intro ...

  10. Governance — CBIIT: Welcome to the NCI Center for Biomedical Informatics and Information Technology

    Cancer.gov

    Established in mid-2011 by the NCAB, the IWG is charged with providing strategic guidance and direction on NCI informatics investments that support the Institute’s scientific goals. The IWG provides a venue for identifying high-priority biomedical informatics needs, harmonizing ongoing and proposed informatics projects across NCI programs, both intramural and extramural, and reducing redundancies wherever possible.

  11. NCI support for particle therapy: past, present, future.

    PubMed

    Deye, James A

    2012-11-01

    In light of the rising worldwide interest in particle therapy, and proton therapy specifically in the United States, the National Cancer Institute (NCI) is being asked more often about funding for such research and facilities. Many of the questions imply that NCI is naive to the exciting possibilities inherent in particle therapies, and thus they wish to encourage NCI to initiate and underwrite such programs. In fact, NCI has a long track record of support for the translation of hadrons from the physics laboratory to the therapy clinic by way of technology development and scientific investigations of physical and biological processes as well as clinical outcomes. Early work has included continuous funding since 1961 of proton treatments for more than 15,000 patients and facility construction at the Harvard/Massachusetts General Hospital (MGH) site; treatment of 227 patients with the pi-meson facility at Los Alamos between 1974 and 1981; funding of more than $69M for seven neutron therapy centers between 1971 and 1989; many funded projects in boron neutron capture radiation therapy through the present time; and numerous radiobiology projects over the past 50 y. NCI continues to play an active role in the incorporation of protons into randomized clinical trials through the Children's Oncology Group, Radiation Therapy Oncology Group, and the Program Project Grant (P01), which is co-directed by the MGH and MD Anderson Cancer Center. This has required funding development and implementation of guidelines that enable intercomparison of dosimetry and treatment between facilities. NCI has also funded recent efforts to develop new physical processes for the production of particles such as protons. With regard to the future, while it is true that there are no specific funding opportunity announcements directed to particle therapy research, it is also true that NCI remains open to reviewing any research that is compatible with an established mechanism. However, given the very substantial resources that these facilities currently require along with the highly competitive economic environment that now exists, it is clear that scientific review of such grant applications will look to leverage the scientific pursuits that are the NCI mandate with the reality of the clinical practices, just as is the case for photon radiation research. Such leveraging should be enhanced by the growing opportunities and need for international collaborations. On the other hand, these collaborations are complicated by the fact that these particle therapies are now fully reimbursable modalities, which makes it difficult to separate research (the NCI mission) from clinical practice development. This paper seeks to illuminate these new realities in order to encourage the pursuit and funding of the scientific underpinnings of physical methods, radiobiology, and clinical practice with particle therapy. PMID:23032896

  12. Pros and Cons of a Group Webpage Design Project in a Freshman Anatomy and Physiology Course

    ERIC Educational Resources Information Center

    Crisp, Kevin M.; Jensen, Murray; Moore, Randy

    2007-01-01

    To generate motivation and promote the development of written communication skills, students in a freshman-level anatomy and physiology course for nonmajors created group webpages describing historically important diseases. After the groups had been formed, each individual was assigned specific components of the disease (e.g., causes or…

  13. NCI at a Glance Infographic (Infographic)

    Cancer.gov

    The National Cancer Institute (NCI) leads the cancer research community toward accelerating the rate of scientific discovery and reducing the burden of cancer in the United States and around the world. NCI is the federal government's principal agency

  14. 2013 NCI Cohort Consortium Annual Meeting

    Cancer.gov

    The annual NCI Cohort Consortium meeting, sponsored by EGRP and the Division of Cancer Epidemiology and Genetics (DCEG), was held on November 18-19, 2013, at the NCI Shady Grove Campus in Rockville, Maryland.

  15. Download the NCI FYI Mobile App

    Cancer.gov

    The NCI @ NIH Fellows and Young Investigators (NCI @ NIH FYI) mobile application offers a centralized source of available resources to fellows and trainees working on the NIH main Campus in Bethesda, MD, off campus in the surrounding area in Rockville,

  16. Teleconference Summary: NCI Clinical Trials Systems

    Cancer.gov

    Over the course of several years, NCI has held extensive discussions with stakeholders, including the scientific and advocacy communities and national advisory boards, about ways to improve and modernize the NCI clinical trials systems (e.g., the 2005 NCI Clinical Trials Working Group Report, the 2010 NCI Operational Efficiency Working Group Report, and the 2010 Institute of Medicine Report). Each of these reports, coupled with regular input from our stakeholders, guided the current changes.

  17. The LINDSAY Virtual Human Project: an immersive approach to anatomy and physiology.

    PubMed

    Tworek, Janet K; Jamniczky, Heather A; Jacob, Christian; Hallgrímsson, Benedikt; Wright, Bruce

    2013-01-01

    The increasing number of digital anatomy teaching software packages challenges anatomy educators on how to best integrate these tools for teaching and learning. Realistically, there exists a complex interplay of design, implementation, politics, and learning needs in the development and integration of software for education, each of which may be further amplified by the somewhat siloed roles of programmers, faculty, and students. LINDSAY Presenter is newly designed software that permits faculty and students to model and manipulate three-dimensional anatomy presentations and images, while including embedded quizzes, links, and text-based content. A validated tool measuring impact across pedagogy, resources, interactivity, freedom, granularity, and factors outside the immediate learning event was used in conjunction with observation, field notes, and focus groups to critically examine the impact of attitudes and perceptions of all stakeholders in the early implementation of LINDSAY Presenter before and after a three-week trial period with the software. Results demonstrate that external, personal media usage, along with students' awareness of the need to apply anatomy to clinical professional situations drove expectations of LINDSAY Presenter. A focus on the software over learning, which can be expected during initial orientation, surprisingly remained after three weeks of use. The time-intensive investment required to create learning content is a detractor from user-generated content and may reflect the consumption nature of other forms of digital learning. Early excitement over new technologies needs to be tempered with clear understanding of what learning is afforded, and how these constructively support future application and integration into professional practice. PMID:22791664

  18. nci-2010-fact-book

    Cancer.gov

    Executive Summary Organization Cancer Statistics Budget Data Extramural Programs Fiscal Year 2010 Annual Report ......................................................iii Director's Biography .................................................................... O-1 Former Directors of the NCI......................................................... O-2 National Cancer Advisory Board.................................................. O-4 Boards of Scientific Counselors and Advisors.............................. O-8 President's Cancer Panel ............................................................ O-9 Scientific Program Leaders.

  19. NCI Budget Fact Book Archive

    Cancer.gov

    All of the NCI Budget Fact Books, dating back to 1971, are available as PDFs. FY 2013-2000 FY 2013 FY 2012 FY 2011 FY 2010 FY 2009 FY 2008 FY 2007 FY 2006 FY 2005 FY 2004 FY 2003 FY 2002 FY 2001 FY 2000 FY 1999-1990 FY 1999 FY 1998 FY

  20. NCI DTP - Discovery Services - NCI-60 Screening Services

    Cancer.gov

    The Developmental Therapeutics Program (DTP) operates a progressive, tiered in vitro and in vivo anti-cancer compound screening program for single pure compounds with the goal of identifying and evaluating novel chemical leads and biological mechanisms of action. The program does not support screening of chemical libraries. The DTP screens include the NCI 60 cell line screen and, as appropriate, the hollow fiber assay and relevant human tumor xenograft and rodent tumor models.

  1. Anatomy Corner

    NSDL National Science Digital Library

    2013-01-01

    This fascinating and informative website was created by a high school teacher in Granite City, Missouri. It brings together a wide range of resources designed to help students learn about anatomy. The materials are divided into three sections: Anatomy Galleries, Anatomy Topics, and Virtual Cat Dissection. The Anatomy Galleries area provides slides, photos, and illustrative materials related to eye dissection, sheep heart dissection, and cat muscles. The Anatomy Topics area includes overviews of the major body systems, including the nervous, circulatory, and endocrine systems. The site also includes a Virtual Cat Dissection, which walks interested parties through this process.

  2. NCI Mouse Repository - Ordering Information

    Cancer.gov

    You may select to have mice recovered for you at NCI-Frederick. After their genotype and health status has been verified, live animals will be delivered to you. You will be notified when mice become available for shipping. Please expect to receive at least one mutant carrier within 16-20 weeks. There is no charge for the cryorecovery procedure. Please note that cryorecoveries may be performed in a facility that has a history of exposure to murine norovirus.

  3. International Activities of NCI Designated Cancer Centers

    Cancer.gov

    This report is not a comprehensive summary of the international efforts of NCI-Designated Cancer Centers and not all of the efforts outlined in this report are NCI or NIH-funded. Rather, this report summarizes information that was provided by Cancer Centers who responded to requests from the NCI Center for Global Health for information on international activities. This is an ongoing data- collection effort, the data collection status for individual cancer centers can be found in Appendix A.

  4. NCI Community Cancer Centers Program - Frequently Asked Questions

    Cancer.gov

    NCI Community Cancer Centers Program - Frequently Asked Questions Search NCCCP Contact Us Overview Frequently Asked Questions Frequently Asked Questions NCI Community Cancer Centers Program Pilot: 2007-2010 Key Points The NCI Community

  5. The Atomic-to-Molecular Transition: Anatomy of a Forming Molecular Cloud. (Follow-up Request for Project C2586)

    NASA Astrophysics Data System (ADS)

    Dawson, Joanne; Mcclure-Griffiths, Naomi; Jones, Paul; Dickey, John; Cunningham, Maria; Jones, Courtney

    2012-04-01

    The formation of molecular clouds from the atomic interstellar medium is a key link in the lifecycle of material in galactic systems, but one that remains poorly observationally constrained. We are currently in the process of obtaining HI, OH and CO line data at parsec and sub-parsec resolutions in order to form a comprehensive picture of the anatomy of a region in which this atomic-molecular transition is occurring (projects C2586, P806 and M614). This combination of tracers will reveal the medium throughout this evolutionary process, providing an unparalleled dataset for comparison with theoretical models, and allowing the testing of key predictions such as structure formation size scales and the degree of interpenetration of the molecular and atomic phases. This proposal requests 12 hours to complete the requirements originally requested for C2586, in order to obtain necessary long-baseline data essential for the HI portion of the project. This data will be used to disentangle complex and blended spatio-velocity structure, resolve streams of converging atomic gas, and assess correlations between HI and CO.

  6. NCI Launches Proteomics Assay Portal

    Cancer.gov

    In a paper recently published by the journal Nature Methods, Investigators from the National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (NCI-CPTAC) announced the launch of a proteomics Assay Portal for multiple reaction monitoring-mass spectrometry (MRM-MS) assays. This community web-based repository for well-characterized quantitative proteomic assays currently consists of 456 unique peptide assays to 282 unique proteins and serves as a public resource of methodologies and data related to cancer associated targets.

  7. INTRODUCTION..........................................................................................................................................................3 ANATOMIE DU DIAPHRAGME.................................................................

    E-print Network

    Promayon, Emmanuel

    ..........................................................................................................................................................3 ANATOMIE DU DIAPHRAGME...............................................................................................................................4 Anatomie morphologique du diaphragme [,]..................................................................................................4 Anatomie fonctionnelle

  8. NCI and the Precision Medicine Initiative

    Cancer.gov

    Under this White House-led initiative, NCI is focusing on three broad areas: new and expanded precision medicine clinical trials; mechanisms to overcome the persistent problem of drug resistance to cancer treatments; and building and sharing a digital repository of data resulting from NCI-sponsored precision medicine clinical trials, all with the aim of bringing precision medicine into everyday clinical practice.

  9. Discovery | NCI Experimental Therapeutics (NExT)

    Cancer.gov

    The Advanced Technology Program (ATP) laboratories at NCI-Frederick are operated by SAIC Frederick, Inc. and were established to provide NCI and other NIH laboratories and initiatives with access to leading-edge technologies and specialized expertise through a tightly integrated, highly effective approach to the study of complex biological problems.

  10. 2009 NCI SBIR Investor Forum Program Book

    Cancer.gov

    LETTER FROM NCI SBIR Welcome to the inaugural National Cancer Institute (NCI) Small Business Innovation Research (SBIR) Investor Forum. Thank you for joining us. I hope that today will be a valuable opportunity for you to learn more about the most

  11. Discovery | NCI Experimental Therapeutics (NExT)

    Cancer.gov

    Skip to Content Search this site DISCOVERY NCINExTInfo@mail.nih.gov Overview Chemical Biology Consortium NExT Diversity Library Discovery Activities in DTP Discovery Activities in CCR Other NCI Programs Last Updated: 09/15/14 OTHER NCI PROGRAMS Cancer

  12. NCI: SBIR & STTR - Funding Opportunities - Receipt Dates

    Cancer.gov

    Please visit this page often to view new opportunities. You may also sign up to receive email updates from the NCI SBIR Development Center announcing new funding opportunities. If you would like to receive updates from the NCI SBIR and STTR Program, please enter your email address into the box below.

  13. NCI-MICCAI Challenge on Brain Tumor

    E-print Network

    Paris-Sud XI, Université de

    I NCI-MICCAI Challenge on Multimodal Brain Tumor Segmentation Proceedings of NCI-MICCAI BRATS 2013 of their unpredictable appearance and shape, segmenting brain tumors from multi-modal imaging data is one of the most; ...), the type of lesion (primary or secondary tumors; solid or infiltratively growing), and the state

  14. Students as resurrectionists--A multimodal humanities project in anatomy putting ethics and professionalism in historical context.

    PubMed

    Hammer, Rachel R; Jones, Trahern W; Hussain, Fareeda Taher Nazer; Bringe, Kariline; Harvey, Ronee E; Person-Rennell, Nicole H; Newman, James S

    2010-01-01

    Because medical students have many different learning styles, the authors, medical students at Mayo Clinic, College of Medicine researched the history of anatomical specimen procurement, reviewing topic-related film, academic literature, and novels, to write, direct, and perform a dramatization based on Robert Louis Stevenson's The Body-Snatcher. Into this performance, they incorporated dance, painting, instrumental and vocal performance, and creative writing. In preparation for the performance, each actor researched an aspect of the history of anatomy. These micro-research projects were presented in a lecture before the play. Not intended to be a research study, this descriptive article discusses how student research and ethics discussions became a theatrical production. This addition to classroom and laboratory learning addresses the deep emotional response experienced by some students and provides an avenue to understand and express these feelings. This enhanced multimodal approach to"holistic learning" could be applied to any topic in the medical school curriculum, thoroughly adding to the didactics with history, humanities, and team dynamics. PMID:20827724

  15. Human Anatomy

    NSDL National Science Digital Library

    Ms. Schultz

    2007-11-09

    Please find links below: Human Anatomy Human Anatomy Online Human Body - Gray s Anatomy - Digestive Aparatus MEDtropolis - Virtual Body - can be viewed in English or Spanish. Contains tours of the Human Brain, Skeleton, Human Heart, and Digestive Tract. Respiratory System National Heart, Lung, and Blood Institute HealthTalk COPD (chronic obstructive pulmonary disease) American Lung Association - Disease Finder Association of Legal Aid Attorneys/UAW 2325 Canadian Lung Association Kids Health Family Living and Personal Living - Ms. Schultz added this link because on this page there is CDC, American ...

  16. nci-2009-fact-book

    Cancer.gov

    Total Extramural Funds 3,756.3 3,720.7 3,733.2 3,732.0 3,800.9 1.2% Mechanism 2005 2006 2007 2008 2009 05-09% chg. Intramural Research $711.0 $687.3 $706.2 $718.4 $781.4 9.9% RMS 173.7 184.1 188.7 231.0 384.6 121.4% Control Inhouse 154.0 155.0 164.5 146.3 0.0 -100.0% Total Inhouse Funds 1,038.7 1,026.5 1,059.4 1,095.7 1,166.0 12.3% Total NCI 4,795.0 4,747.2 4792.6 4,827.7 4,966.9 3.6% Inhouse National Cancer Institute Extramural vs.

  17. NCI DEA - DCLG Archive Meeting Information

    Cancer.gov

    National Institutes of Health, National Cancer Institute, Division of Extramural Activities - Home Page Skip to Main Content Home Funding Advisory Consumer Guides FAQs & Glossary Awarded Research Division of Extramural Activities NCI Council of Research

  18. 2007 NCI Cohort Consortium Annual Meeting Agenda

    Cancer.gov

    Skip to Main Content at the National Institutes of Health | www.cancer.gov Epidemiology and Genomics Research In NCI's Division of Cancer Control and Population Sciences Search EGRP: Main Menu EGRP Home About the Program Mission & Vision Organizational

  19. Discovery | NCI Experimental Therapeutics (NExT)

    Cancer.gov

    The NCI Alliance for Nanotechnology in Cancer is in the initial stage of product development and could provide important new platforms for the development and delivery of novel molecules discovered by the CBC.

  20. NCI: SBIR & STTR - Past Funding - Contract Topics

    Cancer.gov

    Additionally, please refer to the following cancer-related topic issued by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The funding was provided by NIDDK while the receipt, review, and contracting was handled by NCI.

  1. NCI: SBIR & STTR - Past Funding - Contract Topics

    Cancer.gov

    Download slides from the NCI SBIR contracts funding webinar. An audio recording and transcript of the webinar are also available for download. Please click here for answers to frequently asked questions on contract funding opportunities.

  2. Discovery | NCI Experimental Therapeutics (NExT)

    Cancer.gov

    Skip to Content Search this site DISCOVERY NCINExTInfo@mail.nih.gov Overview Chemical Biology Consortium NExT Diversity Library Discovery Activities in DTP Discovery Activities in CCR Other NCI Programs Last Updated: 10/28/10 North

  3. NCI announces plans to reinvigorate clinical trials;

    Cancer.gov

    The National Cancer Institute (NCI) has announced major changes to be made in the long-established Clinical Trials Cooperative Group Program that conducts many of the nationwide trials of new cancer therapies.

  4. NCI: SBIR & STTR - Investor Forum - Presenting Companies

    Cancer.gov

    The 28 SBIR-funded companies selected to present at the 2014 NCI SBIR Investor Forum represent promising innovators that are developing the next generation of cancer therapeutics, diagnostics, and devices primed for commercialization.

  5. 2009 NCI Cohort Consortium Annual Meeting Agenda

    Cancer.gov

    Skip to Main Content at the National Institutes of Health | www.cancer.gov Epidemiology and Genomics Research In NCI's Division of Cancer Control and Population Sciences Search EGRP: Main Menu EGRP Home About the Program Mission & Vision Organizational

  6. NCI: Research Resources > Resources by Category

    Cancer.gov

    NCI-sponsored Cooperative Group, established to provide for a multi-center network for the systematic study and facilitation of the development and rigorous assessment of technologies relevant to diagnostic imaging of cancer.

  7. NCI-Frederick PHL - Courier Services

    Cancer.gov

    Courier services can be arranged through Stephanie Smith (301-846-1281), Histotechnology Departmental Administrative Assistant, for the collection of animals, samples, or other materials directly from the NIH-Bethesda campus to our laboratory at NCI Frederick.

  8. Extramural NCI Data Access Committee: Contact Us

    Cancer.gov

    Skip to Main Content at the National Institutes of Health | www.cancer.gov Epidemiology and Genomics Research In NCI's Division of Cancer Control and Population Sciences Search EGRP: Main Menu EGRP Home About the Program Mission & Vision Organizational

  9. NCI Contact Center—Cancer Information Service

    Cancer.gov

    The NCI Contact Center (formerly the Cancer Information Service) provides accurate, up-to-date, and reliable information on cancer that is easy to understand. Trained information specialists provide personalized responses to a range of cancer questions.

  10. NIH and NCI Grants-Related Policies

    Cancer.gov

    This section contains links compiled by the Epidemiology and Genomics Research Program (EGRP) to help investigators learn more about NIH and NCI policies related to grant applications and has FAQs related to grants policies.

  11. NCI Shady Grove Metro Shuttle Express Schedule

    Cancer.gov

    National Cancer Institute Shady Grove to NIH Campus Schedule NCI Express NOTE: This schedule is subject to change during periods of inclement weather. OPM scheduled delayed opening, closures and changes in

  12. About the NCI Council of Research Advocates

    Cancer.gov

    The NCRA focuses on matters that facilitate research and often identifies and responds to challenges facing the Institute at the request of NCI leadership. In addition, NCRA members bring their unique skills and perspectives by identifying new approaches, promoting innovation, recognizing unforeseen risks or barriers, and identifying unintended consequences that could result from NCI decisions. The NCRA focuses on enhancing community input, optimizing community outreach, and promoting strong collaborations to improve research outcomes.

  13. NCI Imaging Sciences Working Group (ISWG)

    Cancer.gov

    Dr. Richard Klausner introduced the "Working Group concept," noting that the role of these "think tanks" is to identify an intellectually robust vision for new investment in particular areas of cancer (identified in the NCI Bypass Budget for fiscal years 1997-1998). It is expected that the Working Groups will make recommendations for actions that the NCI can take to advance research opportunities in these areas.

  14. NCI: Research Resources > Resources by Category

    Cancer.gov

    NCI has developed a listing of Glycemic Index (GI) values for individual foods. Food codes from the USDA Continuing Survey of Food Intakes of Individuals (CSFII) are used as a reference. The file provides GI values for those foods consumed by adults and queried on the Diet History Questionnaire (DHQ) or other Food Frequency Questionnaires used at NCI. Two files are provided on the Website. The first is organized by CSFII food code.

  15. Programa de análisis molecular para la elección de tratamientos del NCI (NCI-MATCH)

    Cancer.gov

    Información sobre el Programa de análisis molecular para la elección de tratamientos del NCI (NCI-MATCH), en el cual los investigadores examinarán tejidos de tumor de pacientes con tumores sólidos y linfomas avanzados que han dejado de responder al tratamiento.

  16. NCI-Molecular Analysis for Therapy Choice Program (NCI-MATCH)

    Cancer.gov

    Information about the NCI-Molecular Analysis for Therapy Choice (NCI-MATCH) Program, in which researchers will examine tumor tissue from patients with advanced solid tumors and lymphomas that have stopped responding to treatment and assign patients to treatment arms based on the molecular profiles of their disease.

  17. ANATOMY, MODELLING AND PREDICTION OF AEROSERVOELASTIC ROTORCRAFT-PILOT-COUPLING

    E-print Network

    ANATOMY, MODELLING AND PREDICTION OF AEROSERVOELASTIC ROTORCRAFT-PILOT-COUPLING Massimo Gennaretti and results obtained within the European project ARISTOTEL (2010-2013) are presented. It deals with anatomy project ARISTO- TEL (2010-2013) and specifically on the anatomy, mod- elling and prediction

  18. Anatomy of Alternating Quantifier Satisfiability (Work in progress)

    E-print Network

    Paris-Sud XI, Université de

    Anatomy of Alternating Quantifier Satisfiability (Work in progress) Anh-Dung Phan Technical procedures. We instantiate the generalization to projection functions based on virtual substitutions, i on Satisfiability Modulo Theories, Manchester : United Kingdom (2012)" #12;Anatomy of Alternating Quantifier

  19. NCI Community Cancer Centers Program - Resources - Cancer Continuum

    Cancer.gov

    NCI develops, implements, and evaluates programs across the cancer continuum. To complement these programs, NCI has developed a large variety of educational materials, many of them designed for patients.

  20. 2014 NCI Mechanics in Oncology Workshop Executive Summary

    Cancer.gov

    NCI Division of Cancer Biology Strategic Workshop Prospective Outlook of Mechanics in Oncology Executive Summary, Agenda, and Participants List September 11-12, 2014 NCI Shady Grove, Terrace Room TE406 9609 Medical Center Drive, Rockville, MD 20850

  1. NCI Community Cancer Centers Program - Related Programs Overview

    Cancer.gov

    One or more of the NCCCP�s four focus areas is shared by several NCI programs � including the NCI Cancer Centers Program, Community Clinical Oncology Program, Community Network Program, and others. The NCCCP will incorporate best practices from other NCI community cancer programs in delivering services to these communities.

  2. News Note: NCI Launches Centers of Quantitative Imaging Excellence Program

    Cancer.gov

    NCI is launching a new program to qualify existing NCI designated Cancer Centers with an added attribute -- as Centers of Quantitative Imaging Excellence. This program will significantly decrease potential variability in image procedures done while a patient is undergoing treatment as part of a NCI-sponsored clinical trial.

  3. NCI Community Cancer Centers Program - Related Programs Overview

    Cancer.gov

    One or more of the NCCCP’s four focus areas is shared by several NCI programs – including the NCI Cancer Centers Program, Community Clinical Oncology Program, Community Network Program, and others. The NCCCP will incorporate best practices from other NCI community cancer programs in delivering services to these communities.

  4. Dream Anatomy

    NSDL National Science Digital Library

    For centuries, artists and physicians have rendered the human body and its anatomy in a myriad of ways, and with the invention of the printing press in the 15th century, the number of anatomical drawings and their like multiplied. Drawing on the collections contained within the National Library of Medicine, this revealing digital exhibit explores some of the ways in which human anatomy has been imagined and represented over the past five centuries or so. These images are divided into a number of thematic sections, including "Anatomical Dreamtime", "Getting Real", and "Visionary & Visible". Visitors to the site can also view the winners in a related contest which asked children to draw what they thought the body looked like "under the skin".

  5. Web Anatomy

    NSDL National Science Digital Library

    Jensen, Murray

    The College of Education and Human Development at the University of Minnesota has created this interactive and engaging set of resources designed to help college students learn about anatomy and physiology. Along with the learning modules, visitors can also take part in the rather fun "Anatomy Bowl". Here visitors can take on topics like biochemistry, the heart, and the reproductive system in a format that is quite similar to a certain popular television game show. Moving along, there's the "Self Test" section. Here visitors can take quizzes of varying lengths designed to test their knowledge of fifteen different subjects, including the endocrine system and the lymphatic system. The site also contains a "Timed Tests" area and a more comprehensive "Quiz Bowl" which allows visitors the opportunity to answer seventeen questions across a myriad of topics.

  6. Speed anatomy.

    PubMed

    2015-06-01

    This fun game helps you get to grips with the basics of anatomy. If, like me, you came into nursing with little grasp of human biology, it can help you to understand how we are put together and picture what we look like on the inside. How fast can you point to your liver or gall bladder? And do you know the difference between the auricle and the utricle? PMID:26036394

  7. NCI Computer Services — CBIIT: Welcome to the NCI Center for Biomedical Informatics and Information Technology

    Cancer.gov

    NCS manages the IT infrastructure for the NCI enterprise. This includes the hardware, hardware-maintenance contracts, software, network, labor, structures, and IT policies required to support the scientific and administrative activities of the Institute.

  8. AAA: Anatomy Textbook Reviews

    NSDL National Science Digital Library

    2011-12-23

    This link on the American Anatomists Association (AAA) provides students and teachers with a one stop site for review of anatomy textbook and education resources (ex: flash cards and atlases). Textbooks include clinical anatomy, human anatomy and specialized regions.

  9. NCI International EBV-Gastric Cancer Consortium

    Cancer.gov

    A collaboration among NCI and extramural investigators, established by DCEG in 2006, that utilizes data and biospecimens from completed and ongoing case series and observational studies of gastric cancer to replicate and extend findings from previous studies hindered by small numbers of EBV-positive cases, and to stimulate multidisciplinary research in this area.

  10. NCL Partnerships - NCI - Nanotechnology Characterization Laboratory

    Cancer.gov

    NCI-Frederick focuses on direct research aimed at identifying the causes of cancer, AIDS, and related diseases. More than 100 scientists here are investigating the genetic, molecular, environmental, and behavioral factors that contribute to human cancers, as well as identifying new targets for cancer diagnosis, treatment, and prevention.

  11. NCI: SBIR & STTR - News & Events - Recent Events

    Cancer.gov

    This session provided an overview of the SBIR and STTR Programs and current funding opportunities for innovative biomedical technologies. The presentation included updates on new initiatives at the NCI SBIR Development Center, and practical strategies and tips for developing successful and competitive proposals.

  12. Discovery | NCI Experimental Therapeutics (NExT)

    Cancer.gov

    Sanford-Burnham Medical Research Institute is one of seven NCI-designated basic research Cancer Centers. The Institute is among the world leaders in areas of fundamental interest to anti-cancer drug discovery, including studies focusing on mechanisms of cell survival and cell death, cell motility, invasion and angiogenesis, cell stress and intracellular signaling.

  13. NCI GeoViewer Text-View

    Cancer.gov

    The NCI GeoViewer is not accessible to users of assistive technologies. All of the statistics displayed in the application are available on this page in tabular format. Make your selections based on data source, area, race, and statistic to create an accessible table.

  14. NCI Training and Career Development Inventory

    Cancer.gov

    Office of the Director, NCI DCP CCR DCEG DCCPS DEA DCTD DCB OD OD 2. Organ Systems Branch (SPORES) 3. Cancer Training Branch (CTB) 4. Comprehensive Minority Biomedical Branch (CMBB) 6. Office of Training and Education 5. Office of Preventive Oncology 7. Office of Education 1.

  15. 2009 NCI Cohort Consortium Annual Meeting

    Cancer.gov

    The NCI Cohort Consortium celebrated its 10th anniversary at its annual meeting held on November 5, 2009, in Bethesda, MD. The meeting was sponsored by the Division of Cancer Control and Population Sciences (DCCPS) and the Division of Cancer Epidemiology and Genetics (DCEG).

  16. NCI: Research Resources > Resources by Category

    Cancer.gov

    The Health Information National Trends Survey (HINTS) is a nationally representative, biennial telephone survey of 8,000 randomly selected adults. NCI and extramural communication researchers are analyzing data to gain insight into people's knowledge about cancer, the communication channels through which they obtain health information, and their cancer-related behaviors.

  17. NCI Interactive Budget Analysis Tool

    Cancer.gov

    Broadly based, multidisciplinary, often long-term, research program which has a specific major objective or a basic theme. A program project is directed toward a range of problems having a central research focus in contrast to the usually narrower thrust of the traditional research project.

  18. Anatomy in Surgical Examinations

    Microsoft Academic Search

    Andrew T Raftery

    2002-01-01

    Today, more than ever, the postgraduate surgical trainee requires instruction in anatomy, for no longer does the undergraduate get a thorough grounding in anatomy. In the past, the postgraduate trainee had formal tuition and examination in anatomy at 2nd M.B. and, therefore, only recall and reinforcement of knowledge were necessary to learn the anatomy required for the old Primary Examination

  19. 12) Anatomy Course Outline

    E-print Network

    De Volder, Kris

    12) Anatomy Course Outline 0) Introduction and Course Overview (week 1) 1) Scheme Crash Course (week 1,2) 2) Anatomy of a Language Definition (week 3) 3) Environments and Scope (week 4, 5, 6) 4-Oriented Programming (week 11, 12) 7) Aspect-Oriented Programming (week 13) 22) Anatomy 2) Anatomy of a Language

  20. NCI Map Stories - Geographic Information Systems & Science

    Cancer.gov

    Colorectal Cancer shows incidence, mortality, and screening rate maps for the most recent colorectal cancer statistics. This map story has been released in conjunction with Colorectal Cancer Awareness Month (March 2015). The data was sourced from the State Cancer Profiles website which the NCI and CDC collaborate on. The user can view one map at a time using tabs. Additionally, the user can download the data in tabular, geographic, or PDF format. To see the county layer, zoom in on the map.

  1. NCI-Frederick Receiving and Quarantine Home

    Cancer.gov

    The primary function of the Receiving and Quarantine Facility is to protect the health of the NCI-Frederick animal facilities. This facility holds and tests a variety of animal models that have been requested for importation by investigators to ensure that these strains are not harboring undesirable organisms prior to release into the animal facilities. The staff works closely with investigators to establish a timeline for holding, testing, and rederivation if necessary.

  2. NCI-Frederick PHL - Molecular Pathology

    Cancer.gov

    The Molecular Pathology Group (MPG) is a recent addition to the laboratory Animal Science Program (LASP), at the Frederick, Maryland campus of the National Cancer Institute. This Leidos Biomedical Research, Inc. group is actively working to expand high-quality, pathology-based research application support available to NCI investigators and their collaborators. Its primary role is to extend the capabilities of the existing Leidos Biomedical Research, Inc.

  3. Regulatory Anatomy

    PubMed Central

    2015-01-01

    This article proposes the term “safety logics” to understand attempts within the European Union (EU) to harmonize member state legislation to ensure a safe and stable supply of human biological material for transplants and transfusions. With safety logics, I refer to assemblages of discourses, legal documents, technological devices, organizational structures, and work practices aimed at minimizing risk. I use this term to reorient the analytical attention with respect to safety regulation. Instead of evaluating whether safety is achieved, the point is to explore the types of “safety” produced through these logics as well as to consider the sometimes unintended consequences of such safety work. In fact, the EU rules have been giving rise to complaints from practitioners finding the directives problematic and inadequate. In this article, I explore the problems practitioners face and why they arise. In short, I expose the regulatory anatomy of the policy landscape. PMID:26139952

  4. Human Anatomy

    NSDL National Science Digital Library

    This website, crafted by the State University of New York-Upstate Medical University, brings together key resources for students and others interested in human anatomy. These materials were designed with first year medical students in mind, but they will also be of use to individuals taking biology and other science-related courses. On the site, visitors can make their way through six sections ranging from extremities to the head and neck. Each area contains a variety of detailed anatomical charts, glossaries, and images. Radiology resources are also prominently featured within each section, providing students with a different perspective of the human body through x-rays, CT scans, and MRIs. Other helpful resources include fact sheets, quizzes, teaching materials, and other freely available course materials offered from other medical schools.

  5. Based on 20 published articles, 6 NCI market research reports, 1 literature review submitted to NCI in January, 2004, and the NCI Clinical Trials Education Series.

    E-print Network

    Garfunkel, Eric

    to NCI in January, 2004, and the NCI Clinical Trials Education Series. Clinical Trials Recruitment that one of the major barriers to recruitment and enrollment of patients in clinical trials is patients information on what prevents patients from participating in a clinical trial once recruited. Most

  6. From: Harold Varmus (NIH/NCI) Sent: Thursday, March 07, 2013 9:14 PM

    E-print Network

    Spence, Harlan Ernest

    From: Harold Varmus (NIH/NCI) Sent: Thursday, March 07, 2013 9:14 PM To: NCI Staff Subject into effect as of March 1st . All components of the NIH, including the NCI, are working diligently to assess determined. As I have described in earlier messages and as is detailed on the NCI's web site (https://deaissl.nci.nih

  7. An Overview of NCI’s National Clinical Trials Network

    Cancer.gov

    On March 1, 2014, after several years of extensive consultation and coordination with many stakeholders, NCI transformed its longstanding Cooperative Group program into the new National Clinical Trials Network (NCTN). Guided by recommendations in a 2010 Institute of Medicine (IOM) report, the design and implementation of the NCTN incorporates feedback from Cooperative Group investigators, NCI Comprehensive Cancer Center directors, several NCI working groups, leading cancer researchers, industry representatives, and patient advocates.

  8. SKELETAL ANATOMY The Anatomy of Sea Turtles 53

    E-print Network

    SKELETAL ANATOMY The Anatomy of Sea Turtles 53 intermedium centrale humerus lateral process distal ANATOMY The Anatomy of Sea Turtles54 intermedium humerus medial process centrale radius ulna pisiform) and become sepa- rate elements when skeletons are prepared. #12;SKELETAL ANATOMY The Anatomy of Sea Turtles

  9. Nail anatomy.

    PubMed

    de Berker, David

    2013-01-01

    The nail unit comprises the nail plate, the surrounding soft tissues, and their vasculature and innervation based upon the distal phalanx. The nail plate is a laminated keratinized structure lying on the nail matrix (15-25%), the nail bed with its distal onychodermal band (75-85%), and the hyponychium at its free edge. The distal part of the matrix, the lunula characterized by its half-moon shape, can be observed in some digits. The nail plate is embedded by the proximal and lateral folds. From the proximal nail fold, the cuticle (also known as the eponychium), adheres to the superficial surface of the proximal nail plate. The nail unit possesses a complex and abundant vascular network to ensure adequate blood supply. Finally, both the periungual soft tissues and the nail folds are innervated. The shapes, structure, and inter-relationships of these tissues are factors in the way nails present with disease and how we understand and manage those diseases. In particular, an understanding of the surgical anatomy is important for those undertaking diagnostic or curative operations on the nail. With this knowledge, the most appropriate surgery can be planned and the patient can be provided with accurate and clear guidance to enable informed consent. PMID:24079579

  10. NCI GIS Portal - Geographic Information Systems & Science

    Cancer.gov

    NCI GIS Portal is a web-based station for interactive mapping and visualization of cancer related geo-spatial data. The portal combines Geographic Information Systems (GIS) and Science principles and tools to harmonize a relatively large and multi-dimensional datasets, including population-based cancer statistics and behavioral, environmental, clinical, socioeconomic, and policy data at the county and state levels. The tools that comprise GIS Portal combine intelligent web maps with graphs, charts, tables, and text to inform, educate, and inspire users to generate research hypothesis.

  11. Discovery | NCI Experimental Therapeutics (NExT)

    Cancer.gov

    The University of Minnesota Chemical Diversity Center is based primarily on the capabilities of the Institute for Therapeutics Discovery and Development (ITDD) and the Department of Medicinal Chemistry in collaboration with the NCI-designated Masonic Comprehensive Cancer Center, the College of Pharmacy, the Center for Translational Medicine, and the Minnesota Supercomputing Institute. The University of Minnesota Chemical Diversity Center’s research focus is the discovery and development of anticancer agents, using stateof-the-art chemical, biological, computational, pharmacological and imaging approaches.

  12. Extramural NCI Data Access Committee: Charter

    Cancer.gov

    The Extramural National Cancer Institute (NCI) Data Access Committee (DAC) will review and approve or disapprove all requests from the research community for access to controlled data of genome-wide association studies (GWAS) of cancer and other genotype-phenotype studies (including sequencing and molecular diagnostic assays) for which it is responsible. The Committee evaluates if the request conforms to NIH policies and procedures including consistency of the proposed research use with data use limitations stipulated by the submitting institution for each study.

  13. Anatomy: Spotlight on Africa

    NSDL National Science Digital Library

    Dr. Amadi O Ihunwo (University of the Witwatersrand Anatomical Sciences)

    2008-05-01

    This article describes a survey of African Anatomy Departments in the Medical School setting. The purpose of the survey was to understand how African Anatomy Departments and curriculum compare in various factors to western medical schools.

  14. Digital Standards for NCI Websites and Social Media

    Cancer.gov

    The Digital Standards for NCI Websites and Social Media provide developers and content managers guidance on the visual and content standards, as well as policies and procedures, in effect for National Cancer Institute (NCI) digital media – including traditional and mobile websites, as well as social and new media channels.

  15. Implementation of the NCI’s National Clinical Trials Network

    Cancer.gov

    NCI is launching a new clinical trials research network intended to improve treatment for the more than 1.6 million Americans diagnosed with cancer each year. The new system, NCI’s National Clinical Trials Network (NCTN), will facilitate the rapid initiation and completion of cancer clinical trials at over 3,000 clinical trials sites.

  16. Virtual Human Anatomy

    Microsoft Academic Search

    Lin Yong; J. X. Chen; Yanling Liu

    2005-01-01

    To learn human anatomy, medical students must practice on cadavers, as must physicians when they want to brush up on their anatomy knowledge. However, cadavers are in short supply in medical schools worldwide. One potential solution to this problem is the virtual human anatomy and surgery system. VHASS uses cryosection images - cross-section natural-color images generated by slicing a frozen

  17. The quail anatomy portal.

    PubMed

    Ruparelia, Avnika A; Simkin, Johanna E; Salgado, David; Newgreen, Donald F; Martins, Gabriel G; Bryson-Richardson, Robert J

    2014-01-01

    The Japanese quail is a widely used model organism for the study of embryonic development; however, anatomical resources are lacking. The Quail Anatomy Portal (QAP) provides 22 detailed three-dimensional (3D) models of quail embryos during development from embryonic day (E)1 to E15 generated using optical projection tomography. The 3D models provided can be virtually sectioned to investigate anatomy. Furthermore, using the 3D nature of the models, we have generated a tool to assist in the staging of quail samples. Volume renderings of each stage are provided and can be rotated to allow visualization from multiple angles allowing easy comparison of features both between stages in the database and between images or samples in the laboratory. The use of JavaScript, PHP and HTML ensure the database is accessible to users across different operating systems, including mobile devices, facilitating its use in the laboratory.The QAP provides a unique resource for researchers using the quail model. The ability to virtually section anatomical models throughout development provides the opportunity for researchers to virtually dissect the quail and also provides a valuable tool for the education of students and researchers new to the field. DATABASE URL: http://quail.anatomyportal.org (For review username: demo, password: quail123). PMID:24715219

  18. Entomology 201 Lab 3 Anatomy and

    E-print Network

    Eubanks, Micky

    Entomology 201 Lab 3 Anatomy and Metamorphosis #12;External Anatomy head #12;External Anatomy thorax #12;External Anatomy abdomen #12;External Anatomy abdomen #12;External Anatomy abdomen #12;External Anatomy abdomen #12;External Anatomy abdomen #12;External Anatomy abdomen ovipositor #12;External

  19. Highlights from the 2015 NCI Intramural Scientific Investigators Retreat

    Cancer.gov

    Highlights from the 2015 NCI Intramural Scientific Investigators Retreat, an annual event at which NIH intramural investigators from the Division of Cancer Epidemiology & Genetics and the Center for Cancer Research share their latest research findings.

  20. NCI Requests Targets for Monoclonal Antibody Production and Characterization

    Cancer.gov

    In an effort to provide well-characterized monoclonal antibodies to the scientific community, NCI's Antibody Characterization Program requests cancer-related protein targets for affinity production and distribution.

  1. NCI Requests Cancer Targets for Monoclonal Antibody Production and Characterization

    Cancer.gov

    In an effort to provide well-characterized monoclonal antibodies to the scientific community, NCI's Antibody Characterization Program requests cancer-related protein targets for affinity production and distribution.

  2. Comparative Cardiac Anatomy

    Microsoft Academic Search

    Alexander J. Hill; Paul A. Iaizzo

    Anatomy is one of the oldest branches of medicine, with historical records dating back at least as far as the 3rd century\\u000a bc; animal research dates back equally as far. Aristotle (384–322 bc) studied comparative animal anatomy and physiology, and Erasistratus of Ceos (304–258 bc) studied live animal anatomy and physiology (1). Galen of Pergamum (129–199 ad) is probably the

  3. HUMAN GROSS ANATOMY ANTH 695

    E-print Network

    Auerbach, Benjamin M.

    1 HUMAN GROSS ANATOMY ANTH 695 THE UNIVERSITY OF TENNESSEE Instructor in Anatomy Lecture Series Fridays: 12:20 PM ­ 1:10 PM lectures: 33 ALUMNI MEMORIAL BUILDING Course description: Human Gross Anatomy

  4. How To Apply | NCI Experimental Therapeutics (NExT)

    Cancer.gov

    Please note that a NExT proposal is NOT a grant application. Rather, a NExT proposal is an application to gain access to scientific capabilities and resources available to the NCI with the goal of moving promising anti-cancer concepts and novel agents into clinical testing. Applications to the NExT Program are evaluated for scientific merit, feasibility, novelty, clinical need, and alignment with NCI mission.

  5. Hepatic arterial anatomy: demonstration of normal supply and vascular variants with three-dimensional CT angiography.

    PubMed

    Winter, T C; Nghiem, H V; Freeny, P C; Hommeyer, S C; Mack, L A

    1995-07-01

    Three-dimensional (3D) helical computed tomographic (CT) angiography is a promising method of determining vascular anatomy. This technique is useful in delineating the arterial anatomy of the liver, demonstrating the normal anatomy and vascular variants in a highly visual fashion. The "typical" hepatic arterial anatomy occurs in only 55% of the population, and numerous variants exist; the standard classification system for hepatic arterial anatomy includes 10 variations. After helical scanning, postprocessing with reconstruction algorithms such as shaded surface display and maximum-intensity projection provides highly graphic, easily understandable views of vascular anatomy. The 3D CT angiograms, with their global view of the anatomy and inherent advantage of volumetric rotation of the vascular system, are useful to surgeons and others with limited experience in interpreting axial anatomy. Determination of hepatic arterial anatomy with 3D CT angiography has already been shown to be clinically useful in patients being evaluated for liver transplantation. PMID:7569128

  6. Anatomy of Alternating Quantifier Satisfiability (Work in progress)

    E-print Network

    Monniaux, David

    Anatomy of Alternating Quantifier Satisfiability (Work in progress) Anh-Dung Phan Technical procedures. We instantiate the generalization to projection functions based on virtual substitutions, i. 118­128 #12;Anatomy of Alternating Quantifier Satisfiability A.-D. Phan, N. Bjørner, D. Monniaux

  7. FUTURE OF CONTENT The Stanford Clinical Anatomy SCAnS Library

    E-print Network

    Das, Rhiju

    FUTURE OF CONTENT The Stanford Clinical Anatomy SCAnS Library WHAT IF What if learning about human anatomy and biology in today's digital world was enriched by the ability to view and interact with 3D used to teach anatomy in secondary schools. PEOPLE BEHIND THE PROJECT Alan Detton, PhD, is an anatomist

  8. Computerized anatomy instruction.

    PubMed

    Meals, R A; Kabo, J M

    1986-07-01

    A self-paced gross anatomy teaching package is under development using computer-generated anatomic images controlled by branching instructional software on a personal computer. The package is designed to overcome several problems encountered in the traditional study of anatomy. The capabilities, strengths, and weaknesses of computer-assisted instruction are highlighted. PMID:3522034

  9. Anatomy comic strips.

    PubMed

    Park, Jin Seo; Kim, Dae Hyun; Chung, Min Suk

    2011-01-01

    Comics are powerful visual messages that convey immediate visceral meaning in ways that conventional texts often cannot. This article's authors created comic strips to teach anatomy more interestingly and effectively. Four-frame comic strips were conceptualized from a set of anatomy-related humorous stories gathered from the authors' collective imagination. The comics were drawn on paper and then recreated with digital graphics software. More than 500 comic strips have been drawn and labeled in Korean language, and some of them have been translated into English. All comic strips can be viewed on the Department of Anatomy homepage at the Ajou University School of Medicine, Suwon, Republic of Korea. The comic strips were written and drawn by experienced anatomists, and responses from viewers have generally been favorable. These anatomy comic strips, designed to help students learn the complexities of anatomy in a straightforward and humorous way, are expected to be improved further by the authors and other interested anatomists. PMID:21634024

  10. An NCI perspective on creating sustainable biospecimen resources.

    PubMed

    Vaught, Jimmie; Rogers, Joyce; Myers, Kimberly; Lim, Mark David; Lockhart, Nicole; Moore, Helen; Sawyer, Sherilyn; Furman, Jeffrey L; Compton, Carolyn

    2011-01-01

    High-quality biospecimens with appropriate clinical annotation are critical in the era of personalized medicine. It is now widely recognized that biospecimen resources need to be developed and operated under established scientific, technical, business, and ethical/legal standards. To date, such standards have not been widely practiced, resulting in variable biospecimen quality that may compromise research efforts. The National Cancer Institute (NCI) Office of Biorepositories and Biospecimen Research (OBBR) was established in 2005 to coordinate NCI's biospecimen resource activities and address those issues that affect access to the high-quality specimens and data necessary for its research enterprises as well as the broader translational research field. OBBR and the NCI Biorepository Coordinating Committee developed NCI's "Best Practices for Biospecimen Resources" after consultation with a broad array of experts. A Biospecimen Research Network was established to fund research to develop additional evidence-based practices. Although these initiatives will improve the overall availability of high-quality specimens and data for cancer research, OBBR has been authorized to implement a national biobanking effort, cancer HUman Biobank (caHUB). caHUB will address systematically the gaps in knowledge needed to improve the state-of-the-science and strengthen the standards for human biobanking. This commentary outlines the progressive efforts by NCI in technical, governance, and economic considerations that will be important as the new caHUB enterprise is undertaken. PMID:21672889

  11. Neurobiology & AnatomyNeurobiology & Anatomy Welcome and Introduction to the Neurobiology & Anatomy Department

    E-print Network

    Alvarado, Alejandro Sánchez

    Neurobiology & AnatomyNeurobiology & Anatomy Welcome and Introduction to the Neurobiology & Anatomy Department Hello, Welcome to the Neurobiology & Anatomy Department. Below you will find helpful information be found at the University of Utah Human Resources web site. Go to Human Resources Training and Development

  12. NCI Summer Curriculum in Cancer Prevention - Additional Lectures for International Participants

    Cancer.gov

    July 17, 2013 - Dr. Jack Welch discusses cancer drug development in the U.S., NCI's infrastructural role in U.S. clinical trials, international collaborations, and NCI trials in resource-constrained settings.

  13. 78 FR 2678 - Proposed Collection; Comment Request (60-Day FRN): The National Cancer Institute (NCI...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-14

    ...Cancer Institute (NCI) SmokefreeTXT (Text Message) Program Evaluation (NCI) SUMMARY...efficacy of the SmokefreeTXT program, a text message smoking cessation intervention...data using the bidirectional aspect of text- messaging service and a series of...

  14. American Type Culture Collection MTA Addendum for the NCI PBCF CONTRACT

    Cancer.gov

    American Type Culture Collection MTA Addendum for the NCI PBCF CONTRACT The National Cancer Institute (NCI) Division of Cancer Biology (DCB) supports and facilitates basic research in all areas of cancer biology at academic institutions and research

  15. Anatomy of the Brain

    MedlinePLUS

    ... Financials Board of Directors Scientific Advisory Council & Reviewers Leadership News Careers Brain Tumor Information Brain Anatomy Brain Tumor Symptoms Diagnosis Types of Tumors Tumor Grade Risk Factors Brain Tumor ...

  16. Anatomy and Physiology Everyday

    NSDL National Science Digital Library

    Teresa Alvarez (St. Louis Community College Forest Park AHNS)

    2008-08-22

    Students use information from newspaper articles to write a paper or presentation on the correlation of information from the article and their understanding of it using knowledge gained in anatomy and physiology class.

  17. Vet Anatomy Lab 

    E-print Network

    Unknown

    2011-08-17

    in the careers of six notable Elizabethans. It deserves a place alongside its new historicist contenders as a rejoinder to be reckoned with. Peter Mitchell. ?The Purple Island? and Anatomy in Early Seventeenth- Century Literature, Philosophy, and Theology...-selected his intended audience, consisting exclusively of advanced graduate students and dedicated seventeenth- century scholars. He has written a book that makes a leisurely, albeit rigorous, case: ?The conceptual metaphors of anatomy and the analo- gies...

  18. EVS (Enterprise Vocabulary Services) — CBIIT: Welcome to the NCI Center for Biomedical Informatics and Information Technology

    Cancer.gov

    The NCI Thesaurus and NCI Metathesaurus provide standard vocabularies for biomedical research. The content of the NCI Thesaurus is available for download in tab-delimited flat file format, Web Ontology Language (OWL) format and in LexGrid XML format. LexEVS is the terminology server used at NCI to support programmatic and web browser access to the vocabularies; it is also available for download and use by third parties.

  19. Evidence-Based Anatomy

    PubMed Central

    Yammine, Kaissar

    2014-01-01

    Anatomy is a descriptive basic medical science that is no longer considered a research-led discipline. Many publications in clinical anatomy are prevalence studies treating clinically relevant anatomical variations and reporting their frequencies and/or associations with variables such as age, sex, side, laterality, and ancestry. This article discusses the need to make sense of the available literature. A new concept, evidence-based anatomy (EBA), is proposed to find, appraise, and synthetize the results reported in such publications. It consists in applying evidence-based principles to the field of epidemiological anatomy research through evidence synthesis using systematic reviews and meta-analyses to generate weighted pooled results. Pooled frequencies and associations based on large pooled sample size are likely to be more accurate and to reflect true population statistics and associations more closely. A checklist of a typical systematic review in anatomy is suggested and the implications of EBA for practice and future research, along with its scope, are discussed. The EBA approach would have positive implications for the future preservation of anatomy as a keystone basic science, for sound knowledge of anatomical variants, and for the safety of medical practice. Clin. Anat. 27:847–852, 2014. PMID:24797314

  20. Ontology-enriched Visualization of Human Anatomy

    SciTech Connect

    Pouchard, LC

    2005-12-20

    The project focuses on the problem of presenting a human anatomical 3D model associated with other types of human systemic information ranging from physiological to anatomical information while navigating the 3D model. We propose a solution that integrates a visual 3D interface and navigation features with the display of structured information contained in an ontology of anatomy where the structures of the human body are formally and semantically linked. The displayed and annotated anatomy serves as a visual entry point into a patient's anatomy, medical indicators and other information. The ontology of medical information provides labeling to the highlighted anatomical parts in the 3D display. Because of the logical organization and links between anatomical objects found in the ontology and associated 3D model, the analysis of a structure by a physician is greatly enhanced. Navigation within the 3D visualization and between this visualization and objects representing anatomical concepts within the model is also featured.

  1. 2011 FRIENDS-OF-NCI-EGRP News Flashes

    Cancer.gov

    The following is an archive of listserv announcements, or "News Flashes" sent by the Epidemiology and Genetics Research Program (EGRP) to FRIENDS-OF-NCI-EGRP LISTSERV subscribers. These occasional announcements communicate information about funding opportunities related to cancer epidemiology, grantsmanship issues, research resources, and other relevant news.

  2. 2010 FRIENDS-OF-NCI-EGRP News Flashes

    Cancer.gov

    The following is an archive of listserv announcements, or "News Flashes" sent by the Epidemiology and Genetics Research Program (EGRP) to FRIENDS-OF-NCI-EGRP LISTSERV subscribers. These occasional announcements communicate information about funding opportunities related to cancer epidemiology, grantsmanship issues, research resources, and other relevant news.

  3. 2012 FRIENDS-OF-NCI-EGRP News Flashes

    Cancer.gov

    The following is an archive of listserv announcements, or "News Flashes" sent by the Epidemiology and Genetics Research Program (EGRP) to FRIENDS-OF-NCI-EGRP LISTSERV subscribers. These occasional announcements communicate information about funding opportunities related to cancer epidemiology, grantsmanship issues, research resources, and other relevant news.

  4. NCI-Frederick PHL Hematology / Blood Chemistry Request

    Cancer.gov

    NCI-Frederick PHL Hematology / Blood Chemistry Request: Step 1 of 4 Please complete the form below as completely as possible. Required fields are marked with an "*". ACUC Protocol Number* First Name* Last Name* Date* Sp./Strain/Code* Gender* Male Female Both Grp/Geno Building Room Phone Date

  5. 2014 FRIENDS-OF-NCI-EGRP News Flashes

    Cancer.gov

    The following is an archive of listserv announcements, or "News Flashes" sent by the Epidemiology and Genetics Research Program (EGRP) to FRIENDS-OF-NCI-EGRP LISTSERV subscribers. These occasional announcements communicate information about funding opportunities related to cancer epidemiology, grantsmanship issues, research resources, and other relevant news.

  6. Microsoft PowerPoint - Bradley-NCI 062004.ppt

    Cancer.gov

    Labor Market Outcomes of Cancer Survivors NCI R01 CA86045-01A1 Investigators „ Cathy J. Bradley „ David Neumark „ Charles W. Given „ Maryjean Schenk Cancer detection in working age people „ Screening is recommended for working age people, and as screening.

  7. News Note: NCI Scientists Identify a New Inflammatory Syndrome

    Cancer.gov

    NCI scientists have identified a new inflammatory condition called interleukin-6 syndrome caused by Kaposi’s sarcoma-associated herpesvirus (KSHV) in some people with HIV/AIDS. This syndrome will be added to three existing types of KSHV-linked illnesses in people with HIV/AIDS.

  8. NCI: Cancer Mortality Maps and Graphs: Contact Us

    Cancer.gov

    Contact us For technical or navigational difficulties: send a message to the Cancer Atlas administrator (atlasadm@pop.nci.nih.gov). To comment on this Web site: your feedback is greatly appreciated and will help to make this a better resource. Please

  9. NCI Releases Preliminary Data on Genetic Susceptibility for Prostate Cancer

    Cancer.gov

    The National Cancer Institute (NCI), part of the National Institutes of Health, has released new data from the Cancer Genetic Markers of Susceptibility (CGEMS) study on prostate cancer. This information could help identify genetic factors that influence the disease and will be integral to the discovery and development of new, targeted therapies.

  10. CRN Projects

    Cancer.gov

    The CRN Cancer Communication Research Center (CCRC) was funded by NCI in 2008 as a program project (P20) to advance research about cancer communication in clinical settings. Led by Dr. James Dearing (KPC), this is the first communication research center founded within the CRN. The Center identifies, tests, and applies optimal communication and coordination processes that facilitate patient-centered cancer care.

  11. NCI: SBIR & STTR - News & Events - Announcements

    Cancer.gov

    This FOA encourages applications from small businesses that seek additional funding to support the next stage of development for projects that were previously funded under SBIR or STTR Phase II awards from any Federal agency.

  12. The Drosophila anatomy ontology

    PubMed Central

    2013-01-01

    Background Anatomy ontologies are query-able classifications of anatomical structures. They provide a widely-used means for standardising the annotation of phenotypes and expression in both human-readable and programmatically accessible forms. They are also frequently used to group annotations in biologically meaningful ways. Accurate annotation requires clear textual definitions for terms, ideally accompanied by images. Accurate grouping and fruitful programmatic usage requires high-quality formal definitions that can be used to automate classification and check for errors. The Drosophila anatomy ontology (DAO) consists of over 8000 classes with broad coverage of Drosophila anatomy. It has been used extensively for annotation by a range of resources, but until recently it was poorly formalised and had few textual definitions. Results We have transformed the DAO into an ontology rich in formal and textual definitions in which the majority of classifications are automated and extensive error checking ensures quality. Here we present an overview of the content of the DAO, the patterns used in its formalisation, and the various uses it has been put to. Conclusions As a result of the work described here, the DAO provides a high-quality, queryable reference for the wild-type anatomy of Drosophila melanogaster and a set of terms to annotate data related to that anatomy. Extensive, well referenced textual definitions make it both a reliable and useful reference and ensure accurate use in annotation. Wide use of formal axioms allows a large proportion of classification to be automated and the use of consistency checking to eliminate errors. This increased formalisation has resulted in significant improvements to the completeness and accuracy of classification. The broad use of both formal and informal definitions make further development of the ontology sustainable and scalable. The patterns of formalisation used in the DAO are likely to be useful to developers of other anatomy ontologies. PMID:24139062

  13. DEPARTMENT OF ANATOMY AND NEUROBIOLOGY

    E-print Network

    Quirk, Gregory J.

    CREDIT-HOURS: 32 (33) First Year: 21 Credit-Hours ANAT 8501 Human Gross Anatomy 8 ANAT 8503 Human Embryology 2 ANAT 8504 Human Cell Biology and Microscopic Anatomy 4 ANAT 8505 Human Neuroanatomy WITH SPECIALTY IN ANATOMY (Ph.D.) TOTAL CREDIT-HOURS: 63 (65) First Year: 21 Credit-Hours ANAT 8501 Human Gross

  14. Virtual Anatomy: From the Body in the Text to the Body on the Screen

    Microsoft Academic Search

    Catherine Waldby

    2000-01-01

    This paper analyzes the transformations in anatomical representation introduced by the Visible Human Project, the first complete virtual anatomy object. By comparing the process of production of book based classical anatomy with that of the Visible Human Project, the paper identifies the medium specificity of anatomical knowledge, the extent to which its powers of demonstration and analysis are conditioned by

  15. Department of Anatomy & Neurobiology

    E-print Network

    Gereau, Robert W. IV

    Department of Anatomy & Neurobiology Department of Anesthesiology Department of Biology Department for Cellular and Molecular Neurobiology McDonnell Center for Systems Neuroscience Washington University PainTexas, Southwestern) Friday October 4, 2013 John Wood, PhD Professor of Molecular Neurobiology Head, Molecular

  16. Anatomy for Biomedical Engineers

    ERIC Educational Resources Information Center

    Carmichael, Stephen W.; Robb, Richard A.

    2008-01-01

    There is a perceived need for anatomy instruction for graduate students enrolled in a biomedical engineering program. This appeared especially important for students interested in and using medical images. These students typically did not have a strong background in biology. The authors arranged for students to dissect regions of the body that…

  17. Illustrated Speech Anatomy.

    ERIC Educational Resources Information Center

    Shearer, William M.

    Written for students in the fields of speech correction and audiology, the text deals with the following: structures involved in respiration; the skeleton and the processes of inhalation and exhalation; phonation and pitch, the larynx, and esophageal speech; muscles involved in articulation; muscles involved in resonance; and the anatomy of the…

  18. Philosophical anatomy revisited

    Microsoft Academic Search

    A. C. Masquelet

    1997-01-01

    Philosophical or transcendental anatomy was a corner stone in the different visions of science which developed in the first half of the XIXth century. It is linked to a fundamental division in biologic sciences: whether animal structure should be explained by reference to function or by morphologic laws. In France, the scientific rivalry of Cuvier and Geoffroy Saint-Hilaire exemplified these

  19. Anatomy of the Honeybee

    ERIC Educational Resources Information Center

    Postiglione, Ralph

    1977-01-01

    In this insect morphology exercise, students study the external anatomy of the worker honeybee. The structures listed and illustrated are discussed in relation to their functions. A goal of the exercise is to establish the bee as a well-adapted, social insect. (MA)

  20. External Anatomy Lab

    NSDL National Science Digital Library

    0000-00-00

    Interactive grasshopper anatomy lessons. Mouthparts, legs, abdomen, various sutures are all featured, as well as well as more general discussions about the types of insect antennae,wings, legs, and mouthparts. An excellent flash demonstration of mouthpart modifications is also featured.

  1. Clinical Topographic Anatomy

    NSDL National Science Digital Library

    2010-01-01

    This website created by faculty at the University of Zurich and University of Australia provides mini-lectures on regional anatomy. The lectures are broken up by the head, neck & trunk, upper limb, lower Limb, thorax, abdomen, and pelvis. Quizzes for each region are also available.

  2. Dilute Aperture Visible Nulling Coronagraph Imaging (DAViNCI)

    NASA Technical Reports Server (NTRS)

    Shao, Michael; Levine, B. M.; Vasisht, G.; Lane, B. F.; Woodruff, R.; Vasudevan, G.; Samuele R.; Harvey, K.; Clampin, M.; Lyon, R.; Guyon, O.; Tolls, V.

    2008-01-01

    The presentation focuses on instrument and mission overview, science case, Team X study, and technology status. Topics include DAViNCI study milestones, number of targets versus inner working angle, planet orbit and IWA, combiner/nuller instrument, DAViNCI Team X costs, technology status and near future plans, and deep laser null 1.23 x 10(exp -7) suppression. Summary points are: dilute aperture concept advantages, lower cost than a comparable 7-8m coronagraph working at 2 lambda/D, technology progress prior to 2008 was seriously limited by available funding but showed 1e-y suppression (2006) of laser light needed for 1e-9 to approximately 1e-10 contrast, and current technology effort is off to a fast date with a demonstration of less than 100pm wavefront measurement in Nov 08.

  3. Industry Collaboration — NCI - Cooperative Group - Industry Relationship Guidelines

    Cancer.gov

    Each CTA or CRADA defines certain obligations for the government and the Collaborator. Generally, these obligations focus on intellectual property and data rights, which may arise pursuant to these studies. Under federal funding agreement guidelines and the agreements in place between the Cooperative Groups and the NCI, certain obligations and guidelines apply to the Cooperative Groups. Compliance with any of the guidelines (in particular, publication review, data access, and intellectual property licensing) is mandatory for the Cooperative Group.

  4. Division of Cancer Epidemiology and Genetics (DCEG), NCI, NIH

    Cancer.gov

    The Division of Cancer Epidemiology and Genetics (DCEG) is a research program of the National Cancer Institute (NCI), one of the National Institutes of Health (NIH). The Division is the world’s most comprehensive cancer epidemiology research group. Its renowned epidemiologists, geneticists, and biostatisticians conduct population and multidisciplinary research to discover the genetic and environmental determinants of cancer and new approaches to cancer prevention. The Division’s research impacts public health policy in the United States and around the world.

  5. Symposium: Applying NCI Etiologic Epidemiologic Discoveries to Reduce Cancer Burden

    Cancer.gov

    Etiologic epidemiologists at NCI study the patterns, determinants and development of cancer. The successful identification of a causal exposure or informative biomarker raises hopes of subsequent application to reducing cancer incidence and mortality, but a strong finding of association does not necessarily mandate or assure application. The formal study of how best to apply etiologic epidemiologic findings is not new, but methods are evolving and thus this topic merits increased cooperative attention from etiologists and application researchers.

  6. NCI Community Cancer Centers Program - Related Programs - Cancer Information Service

    Cancer.gov

    The National Cancer Institute�s (NCI) Cancer Information Service (CIS) educates the public about cancer prevention, risk factors, symptoms, diagnosis, treatment, and research . CIS information specialists provide the latest, most accurate information about cancer by telephone, TTY, instant messaging, and e-mail and operates the NCI�s Smoking Quitline. Through its Partnership Program, the CIS works with established national, regional, and state organizations to reach those most in need of cancer information.

  7. Human ocular anatomy.

    PubMed

    Kels, Barry D; Grzybowski, Andrzej; Grant-Kels, Jane M

    2015-01-01

    We review the normal anatomy of the human globe, eyelids, and lacrimal system. This contribution explores both the form and function of numerous anatomic features of the human ocular system, which are vital to a comprehensive understanding of the pathophysiology of many oculocutaneous diseases. The review concludes with a reference glossary of selective ophthalmologic terms that are relevant to a thorough understanding of many oculocutaneous disease processes. PMID:25704934

  8. NCI Community Cancer Centers Program - Pilot Subcommittees - NCCCP Program Advisory Committee

    Cancer.gov

    NCI Community Cancer Centers Program - Pilot Subcommittees - NCCCP Program Advisory Committee Search NCCCP Pilot Goals Overview Pilot Subcommittees Pilot Executive Subcommittee Disparities Clinical Trials Information

  9. University of Oregon Human Anatomy I

    E-print Network

    Lockery, Shawn

    University of Oregon Human Anatomy I HPHY 321 Fall 2013 Monday learning opportunity occurs if students choose to take HPHY 321 (Anatomy I Resources: 1. Anatomy & Physiology Revealed 3.0, Web-Based Program. This is a great

  10. HUMAN GROSS ANATOMY ANTH 695 SPRING 2014

    E-print Network

    Auerbach, Benjamin M.

    1 HUMAN GROSS ANATOMY ANTH 695 ­ SPRING 2014 THE UNIVERSITY OF TENNESSEE description: Human Gross Anatomy provides advanced graduate students with in in Anatomy Lecture Series Fridays: 12:20 PM ­ 1:10 PM * All

  11. Anatomy Adventure: A Board Game for Enhancing Understanding of Anatomy

    ERIC Educational Resources Information Center

    Anyanwu, Emeka G.

    2014-01-01

    Certain negative factors such as fear, loss of concentration and interest in the course, lack of confidence, and undue stress have been associated with the study of anatomy. These are factors most often provoked by the unusually large curriculum, nature of the course, and the psychosocial impact of dissection. As a palliative measure, Anatomy

  12. The anatomy of anatomy: a review for its modernization.

    PubMed

    Sugand, Kapil; Abrahams, Peter; Khurana, Ashish

    2010-01-01

    Anatomy has historically been a cornerstone in medical education regardless of nation or specialty. Until recently, dissection and didactic lectures were its sole pedagogy. Teaching methodology has been revolutionized with more reliance on models, imaging, simulation, and the Internet to further consolidate and enhance the learning experience. Moreover, modern medical curricula are giving less importance to anatomy education and to the acknowledged value of dissection. Universities have even abandoned dissection completely in favor of user-friendly multimedia, alternative teaching approaches, and newly defined priorities in clinical practice. Anatomy curriculum is undergoing international reformation but the current framework lacks uniformity among institutions. Optimal learning content can be categorized into the following modalities: (1) dissection/prosection, (2) interactive multimedia, (3) procedural anatomy, (4) surface and clinical anatomy, and (5) imaging. The importance of multimodal teaching, with examples suggested in this article, has been widely recognized and assessed. Nevertheless, there are still ongoing limitations in anatomy teaching. Substantial problems consist of diminished allotted dissection time and the number of qualified anatomy instructors, which will eventually deteriorate the quality of education. Alternative resources and strategies are discussed in an attempt to tackle these genuine concerns. The challenges are to reinstate more effective teaching and learning tools while maintaining the beneficial values of orthodox dissection. The UK has a reputable medical education but its quality could be improved by observing international frameworks. The heavy penalty of not concentrating on sufficient anatomy education will inevitably lead to incompetent anatomists and healthcare professionals, leaving patients to face dire repercussions. PMID:20205265

  13. NCI intramural research highlighted at 2014 AACR meeting

    Cancer.gov

    This year’s American Association for Cancer Research meeting featured plenary talks by two NCI scientists, Steven Rosenberg, M.D., and Louis Staudt, M.D., Ph.D., that highlighted the challenges in developing varied and potentially synergistic treatments for aggressive forms of cancer. Each researcher has been focusing primarily on a particularly difficult to treat cancer (melanoma and lymphoma, respectively) for many decades, and their presentations highlight the diligence and tenacity needed to come to a better understanding of the cancer process and to find effective agents to target the diseases they study.

  14. Terminology — CBIIT: Welcome to the NCI Center for Biomedical Informatics and Information Technology

    Cancer.gov

    Enterprise Vocabulary Services (EVS) works with NCI and extramural partners to develop, license, and publish terminology; to support software applications; and to promote harmonization and shared standards. EVS provides the foundational layer for NCI's informatics infrastructure, and participates in federal and international standards efforts.

  15. AACR 2015: NCI Exhibit Booth: Center for Cancer Genomics “Meet the Experts” Session

    Cancer.gov

    Home News and Events Events AACR 2015:“Meet the Experts” Session AACR 2015: NCI Exhibit Booth: Center for Cancer Genomics “Meet the Experts” Session Monday, April 20, 2015, 10:30 AM - 11:00 AM NCI Exhibit Booth (#601), Pennsylvania Convention Center,

  16. About CBIIT — CBIIT: Welcome to the NCI Center for Biomedical Informatics and Information Technology

    Cancer.gov

    NCI created CBIIT to lead the coordination, development, and deployment of enterprise-wide digital capabilities (including biomedical informatics, scientific-management information systems, and computing resources) in support of the Institute's initiatives. Through CBIIT, NCI is helping to speed scientific discovery and facilitate translational research by using IT and informatics to address complex research challenges.

  17. Webinar Summary: A Conversation with NCI Acting Director, Dr. Douglas R Lowy

    Cancer.gov

    In his remarks, Dr. Lowy broadly discussed the President’s budget proposal for the Precision Medicine Initiative and the proposed increase in funding for NCI and NIH. In closing, he outlined the federal budget cycle and highlighted NCI’s infrastructure and purchasing power.

  18. TEMPORAL DYNAMICS OF BRAIN ANATOMY

    E-print Network

    Thompson, Paul

    1 TEMPORAL DYNAMICS OF BRAIN ANATOMY Arthur W. Toga and Paul M. Thompson Laboratory of Neuro-mail: toga@loni.ucla.edu Words= Pages= Figures= #12;2 TEMPORAL DYNAMICS OF BRAIN ANATOMY Arthur W. Toga The brain changes profoundly in structure and function during development, and as a result of diseases

  19. Health Instruction Packages: Cardiac Anatomy.

    ERIC Educational Resources Information Center

    Phillips, Gwen; And Others

    Text, illustrations, and exercises are utilized in these five learning modules to instruct nurses, students, and other health care professionals in cardiac anatomy and functions and in fundamental electrocardiographic techniques. The first module, "Cardiac Anatomy and Physiology: A Review" by Gwen Phillips, teaches the learner to draw and label…

  20. Anatomie et physiologieAnatomie et physiologie de lde l''oreilleoreille

    E-print Network

    Jacquet, Stéphan

    Anatomie et physiologieAnatomie et physiologie de lde l''oreilleoreille Picut GPicut Gééraldrald Mf1/bees1Mf1/bees1 Horizon plongHorizon plongéée 2007e 2007 #12;Anatomie /physiologieAnatomie /physiologie cc''est quoi ?est quoi ? · Anatomie = constitution de l' organe · ( de quoi il est fait

  1. Intrinsic and Extrinsic Analysis on Computational Anatomy

    E-print Network

    Paris-Sud XI, Université de

    Intrinsic and Extrinsic Analysis on Computational Anatomy Anqi Qiu1 , Laurent Younes1 , Michael I Computational Anatomy (CA) [1] is a discipline which is evolving rapidly world- wide. The three major areas in the anatomy. 68 Mathematical Foundations of Computational Anatomy (MFCA'06) inria-00635889,version1-26Oct2011

  2. BIM Anatomy An investigation into implementation prerequisites

    E-print Network

    BIM Anatomy An investigation into implementation prerequisites Martin Hooper #12;BIM Anatomy Title: BIM Anatomy An investigation into implementation prerequisites Published: 2012 Design SE221 00 Lund Sweden Tel: +46 (0)46 222 48 63 #12;BIM Anatomy: An investigation

  3. Rapid Interaction of Helicobacter pylori with Microvilli of the Polar Human Gastric Epithelial Cell Line NCI-N87

    PubMed Central

    Diesing, Anne-Kathrin; Nossol, Constanze; Faber-Zuschratter, Heidi; Zuschratter, Werner; Renner, Lydia; Sokolova, Olga; Naumann, Michael; Rothkötter, Hermann-Josef

    2013-01-01

    Infection with Helicobacter pylori results often in chronic gastritis, gastric ulcers or even gastric tumor development. Little is known about the initial interaction between gastric epithelial cells and H. pylori. The aim of the present study was to analyze the initial host contact to the bacteria. Monolayers of the human gastric epithelial cell line NCI-N87 grown on porous membranes were used and the apical side of the epithelium was exposed to the H. pylori wild-type strain P1 for 1 hr. Many epithelial cells were colonized by bacteria within the period of 60 min. Using scanning electron microscopy we detected that the bacteria were in close contact with the epithelia via microvilli. Further, transmission electron microscopy of the contact sites revealed no difference in the morphology of the microvilli in comparison to those not attached to the bacteria. The present study demonstrates the importance of microvilli on apical epithelial cells during the initial contact of the host by colonizing H. pylori. Anat Rec, 296:1800–1805, 2013. © 2013 The Authors. The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology published by Wiley Periodicals, Inc. on behalf of the American Association of Anatomists. PMID:24136815

  4. Carpal Ligament Anatomy and Biomechanics.

    PubMed

    Pulos, Nicholas; Bozentka, David J

    2015-08-01

    A fundamental understanding of the ligamentous anatomy of the wrist is critical for any physician attempting to treat carpal instability. The anatomy of the wrist is complex, not only because of the number of named structures and their geometry but also because of the inconsistencies in describing these ligaments. The complex anatomy of the wrist is described through a review of the carpal ligaments and their effect on normal carpal motion. Mastery of this topic facilitates the physician's understanding of the patterns of instability that are seen clinically. PMID:26205699

  5. Incorporating 3D virtual anatomy into the medical curriculum

    Microsoft Academic Search

    Celina Imielinska; Pat Molholt

    2005-01-01

    The introduction of the Visible Human Project by Ackerman in 1995, described in the seminal paper in 1996 [9], brought a promise to anatomists that these two frozen, milled, and digitized cadavers---the Visible Male and Female---would revolutionize anatomy teaching by providing the most complete and detailed anatomical images ever. This vision could be compared to the proverbial \\

  6. Anatomy of Alternating Quantifier Satisfiability (Work in progress)

    E-print Network

    Bjørner, Nikolaj S.

    Anatomy of Alternating Quantifier Satisfiability (Work in progress) Anh-Dung Phan Technical procedures. We instantiate the generalization to projection functions based on virtual substitutions, i for producing candidate formulas. Section 4 instantiates the algorithm with a concrete procedure for virtual

  7. WebAnatomy.net

    NSDL National Science Digital Library

    Swan, Jim

    With a longtime presence on the web, Professor Jim Swan of the University of New Mexico has created a fine set of online anatomy and physiology resources that he uses in his courses on a regular basis. Students of the human body will also want to avail themselves of these materials, which include sets of pathology images and slides that cover such conditions as coronary artery thrombosis, atherosclerosis, and so on. One rather handy section includes weblab modules that introduce acolytes to the world of the heart, the lungs, and the digestive system through slides and interactive photos. The site is rounded out by the �Virtual Microscope� area, which includes detailed slides and explanations of cartilage, bone, blood, and muscular tissue.

  8. Please complete and give to Karen Evans in 401 MREB Neurobiology & AnatomyNeurobiology & Anatomy

    E-print Network

    Alvarado, Alejandro Sánchez

    Please complete and give to Karen Evans in 401 MREB Neurobiology & AnatomyNeurobiology & Anatomy: Microbiology Neuroscience Anatomy Lab Name: Lab Location: Lab Ph #: Bldg. Rm # EMERGENCY CONTACT INFORMATION

  9. Project Year Project Team

    E-print Network

    Gray, Jeffrey J.

    and acoustics in a coupled, comprehensive manner. Solution We propose to create a series of virtual mini of introductory material, such as basic anatomy and signal processing techniques. In the setting of a one topics. To address this problem, this project team will create a CD with a series of virtual mini

  10. The assessment of virtual reality for human anatomy instruction

    NASA Technical Reports Server (NTRS)

    Benn, Karen P.

    1994-01-01

    This research project seeks to meet the objective of science training by developing, assessing, and validating virtual reality as a human anatomy training medium. In ideal situations, anatomic models, computer-based instruction, and cadaver dissection are utilized to augment the traditional methods of instruction. At many institutions, lack of financial resources limits anatomy instruction to textbooks and lectures. However, human anatomy is three dimensional, unlike the one dimensional depiction found in textbooks and the two dimensional depiction found on the computer. Virtual reality is a breakthrough technology that allows one to step through the computer screen into a three dimensional world. This technology offers many opportunities to enhance science education. Therefore, a virtual testing environment of the abdominopelvic region of a human cadaver was created to study the placement of body parts within the nine anatomical divisions of the abdominopelvic region and the four abdominal quadrants.

  11. Administrative Supplement to Strengthen NCI-Supported Community Outreach Capacity through Community Health Educators (CHEs) of the National Outreach Network (NON)

    Cancer.gov

    The Center to Reduce Cancer Health Disparities (CRCHD) of the National Cancer Institute (NCI), in partnership with the NCI Office of Cancer Centers (OCC) and the NCI Office of Communications and Public Liaison (OCPL), announces the opportunity to compete for administrative supplements to the Cancer Center Support Grants (CCSGs) for NCI-designated Cancer Centers (P30) to strengthen community outreach capacity through Community Health Educators (CHE) of the NCI National Outreach Network (NON).

  12. Interoperability and Semantics — CBIIT: Welcome to the NCI Center for Biomedical Informatics and Information Technology

    Cancer.gov

    The NCI semantic infrastructure includes end-user applications, services, and content for helping to achieve interoperability, data integration, and data sharing through the use of metadata, models, and controlled terminology.

  13. SAIC/NCI-Frederick’s Nanotechnology Characterization Lab (NCL) is pleased to announce that Dr

    Cancer.gov

    Dr. Martin Fritts, Senior Principal Scientist and Co-Founder of the NCL, Receives the 2010 ASTM International President’s Leadership Award SAIC/NCI-Frederick’s Nanotechnology Characterization Lab (NCL) is pleased to announce that Dr. Martin Fritts

  14. Agenda for the Second NCI Epidemiology Leadership Workshop: Understudied Rare Cancers

    Cancer.gov

    Skip to Main Content at the National Institutes of Health | www.cancer.gov Epidemiology and Genomics Research In NCI's Division of Cancer Control and Population Sciences Search EGRP: Main Menu EGRP Home About the Program Mission & Vision Organizational

  15. Mission — CBIIT: Welcome to the NCI Center for Biomedical Informatics and Information Technology

    Cancer.gov

    The Center for Biomedical Informatics and Information Technology provides and advocates for the appropriate use of data science, informatics, and information technology (IT) to support and accelerate the NCI mission to prevent and cure cancer.

  16. 75 FR 46945 - Proposed Collection; Comment Request; the Drug Accountability Record (Form NIH 2564) (NCI)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-04

    ...the Drug Accountability Record (Form NIH 2564) (NCI) SUMMARY: In compliance with...the National Institutes of Health (NIH) will publish periodic summaries of proposed...The Drug Accountability Record (Form NIH 2564) (OMB No. 0925-0240). Type...

  17. [Dental anatomy of dogs].

    PubMed

    2014-12-01

    The aim of the research was to investigate dog teeth anatomy as animal model for study of etiopathogenesis of caries disease and physiological tooth wear in human. After examining the dog's dental system, following conclusions were drawn: the dog has 42 permanent teeth, which are distributed over the dental arches not equally, and so the upper dentition consists of 20, and the lower of 22 teeth. The largest are considered upper fourth premolar and lower first molars, which are called discordant teeth. Between discordant teeth and fangs a dog has an open bite, which is limited to the top and bottom conical crown premolar teeth. Thus, in the closed position of the jaws, behind this occlusion is limited by discordant teeth, just in contact are smaller in size two molars. Only large dog's molars in a valid comparison can be likened to human molars, which allows us to use them in an analog comparison between them with further study of the morphological features ensure durability short-crown teeth and their predisposition to caries. PMID:25617107

  18. NCI: SBIR & STTR - Past Funding Opportunities - Contracts - 229 Development of Molecular Pharmacodynamic Assays for Targeted Therapies

    Cancer.gov

    The NCI requests that qualified small businesses submit proposals to develop pharmacodynamic assays for measuring a number of high-priority molecular targets. (For a list of the targets of interest to NCI, please click here). The short term goal of this contract is to develop new rigorous, validated assays to measure molecular-level response to treatment in conjunction with preclinical development of new candidate therapeutic agents.

  19. NCI-MATCH trial will link targeted cancer drugs to gene abnormalities

    Cancer.gov

    Investigators for the nationwide trial, NCI-MATCH: Molecular Analysis for Therapy Choice, announced that the trial will seek to determine whether targeted therapies for people whose tumors have specific gene mutations will be effective regardless of their cancer type. NCI-MATCH will incorporate more than 20 different study drugs or drug combinations, each targeting a specific gene mutation, in order to match each patient in the trial with a therapy that targets a molecular abnormality in their tumor.

  20. Metathesaurus Downloads — CBIIT: Welcome to the NCI Center for Biomedical Informatics and Information Technology

    Cancer.gov

    This page contains hyperlinks to most of the files associated with the NCI Metathesaurus (NCIm) distribution, the exception being the actual NCIm data files which requires validation of your UMLS credentials. The NCIm is built on top of a subset of the National Library of Medicine's (NLM) UMLS Metathesaurus, use of which is restricted under the UMLS license agreement and requires us to validate your UMLS license. This validation is done from a separate page (see "NCI Metathesaurus Data File Downloads" below).

  1. The place of surface anatomy in the medical literature and undergraduate anatomy textbooks.

    PubMed

    Azer, Samy A

    2013-01-01

    The aims of this review were to examine the place of surface anatomy in the medical literature, particularly the methods and approaches used in teaching surface and living anatomy and assess commonly used anatomy textbooks in regard to their surface anatomy contents. PubMed and MEDLINE databases were searched using the following keywords "surface anatomy," "living anatomy," "teaching surface anatomy," "bony landmarks," "peer examination" and "dermatomes". The percentage of pages covering surface anatomy in each textbook was calculated as well as the number of images covering surface anatomy. Clarity, quality and adequacy of surface anatomy contents was also examined. The search identified 22 research papers addressing methods used in teaching surface anatomy, 31 papers that can help in the improvement of surface anatomy curriculum, and 12 anatomy textbooks. These teaching methods included: body painting, peer volunteer surface anatomy, use of a living anatomy model, real time ultrasound, virtual (visible) human dissector (VHD), full body digital x-ray of cadavers (Lodox(®) Statscan(®) images) combined with palpating landmarks on peers and the cadaver, as well as the use of collaborative, contextual and self-directed learning. Nineteen of these studies were published in the period from 2006 to 2013. The 31 papers covered evidence-based and clinically-applied surface anatomy. The percentage of surface anatomy in textbooks' contents ranged from 0 to 6.2 with an average of 3.4%. The number of medical illustrations on surface anatomy varied from 0 to 135. In conclusion, although there has been a progressive increase in publications addressing methods used in teaching surface anatomy over the last six to seven years, most anatomy textbooks do not provide students with adequate information about surface anatomy. Only three textbooks provided a solid explanation and foundation of understanding surface anatomy. PMID:23650274

  2. Syllabus Human Anatomy and Human Anatomy Laboratory -Biol 350 Spring 2014 page 1 of 10

    E-print Network

    Houde, Peter

    Syllabus Human Anatomy and Human Anatomy Laboratory - Biol 350 Spring 2014 page 1 of 10 Welcome to Human Anatomy! Except for those destined for medical or dental school, it is assumed that students in this course will not enroll in additional anatomy courses. Thus, it is necessary for this course to provide

  3. Syllabus Human Anatomy and Human Anatomy Laboratory -Biol 350 Fall 2014 page 1 of 10

    E-print Network

    Houde, Peter

    Syllabus Human Anatomy and Human Anatomy Laboratory - Biol 350 Fall 2014 page 1 of 10 Welcome to Human Anatomy! Except for those destined for medical or dental school, it is assumed that students in this course will not enroll in additional anatomy courses. Thus, it is necessary for this course to provide

  4. Data Mining the NCI60 to Predict Generalized Cytotoxicity

    PubMed Central

    Lee, Adam C.; Shedden, Kerby; Rosania, Gustavo R.; Crippen, Gordon M.

    2008-01-01

    Elimination of cytotoxic compounds in the early and later stages of drug discovery can help reduce the costs of research and development. Through the application of principal components analysis (PCA), we were able to data mine and prove that ?89% of the total log GI50 variance is due to the non-specific cytotoxic nature of substances. Furthermore, PCA led to the identification of groups of structurally unrelated substances showing very specific toxicity profiles, such as a set of 45 substances toxic only to the Leukemia_SR cancer cell line. In an effort to predict non-specific cytotoxicity based on the mean log GI50, we created a decision tree using MACCS keys that can correctly classify over 83% of the substances as cytotoxic/non-cytotoxic in silico, based on the cutoff of mean log GI50 = ?5.0. Finally, we have established a linear model using least squares in which 9 of the 59 available NCI60 cancer cell lines can be used to predict the mean log GI50. The model has R2=0.99 and root mean square deviation between the observed and calculated mean log GI50 (RMSE) = 0.09. Our predictive models can be applied to flag generally cytotoxic molecules in virtual and real chemical libraries, thus saving time and effort. PMID:18588283

  5. CARO – The Common Anatomy Reference Ontology

    Microsoft Academic Search

    Melissa A. Haendel; Fabian Neuhaus; David Osumi-Sutherland; Paula M. Mabee; L. V. Mejino Jr; Chris J. Mungall; Barry Smith

    The Common Anatomy Reference Ontology (CARO) is being developed to facilitate interoperability between existing anatomy ontologies\\u000a for different species, and will provide a template for building new anatomy ontologies. CARO has a structural axis of classification\\u000a based on the top-level nodes of the Foundational Model of Anatomy. CARO will complement the developmental process sub-ontology\\u000a of the GO Biological Process ontology,

  6. COMPUTATIONAL ANATOMY: AN EMERGING Ulf Grenandery

    E-print Network

    COMPUTATIONAL ANATOMY: AN EMERGING DISCIPLINE Ulf Grenandery and Michael I. Millerz June 25, 1998 Abstract This paper studies mathematical methods in the emerging new discipline of Computational Anatomy. Herein we formalize the Brown/Washington University model of anatomy following the global pattern theory

  7. NEW CO-CHAIRS FOR ANATOMY &

    E-print Network

    Yates, Andrew

    #12;2 NEW CO-CHAIRS FOR ANATOMY & STRUCTURAL BIOLOGY Drs. John Condeelis and Robert Singer have been named co-chairs of the Department of Anatomy & Structural Biology. They had been serving jointly of anatomy in 1977. Appointed profes- sor in 1987, he currently serves as sci- entific director

  8. Singular solutions, momentum maps and computational anatomy

    E-print Network

    Boyer, Edmond

    Singular solutions, momentum maps and computational anatomy Colin J. Cotter1 and Darryl D. Holm1. This paper describes the variational formulation of tem- plate matching problems of computational anatomy (CA to instruct, or at least entertain, without wearying." ­ Lorenzo da Ponte 1 Introduction Computational Anatomy

  9. Anatomy Department Act of Remembrance and Thanksgiving

    E-print Network

    O'Mahony, Donal E.

    Anatomy Department Act of Remembrance and Thanksgiving ON Wednesday 6th March 2013 AT 5.15pm with the staff and students from the Anatomy Department have an opportunity to show their appreciation readings, singing, and music which is performed by the Chapel Choir and students from the Anatomy Dept

  10. College of Medicine ANA Anatomy and Neurobiology

    E-print Network

    MacAdam, Keith

    completion of ANA 109. ANA 209 PRINCIPLES OF HUMAN ANATOMY. (3-basedundergraduateanatomyandregionally-basedmedicalprofessional anatomy. The human body will be taught in an online format, including modules for independent study.Prereq:Anintroductorycourse in biology, zoology, or botany and consent of instructor. ANA 511 INTRODUCTION TO HUMAN ANATOMY. (5

  11. Lab 2: Anatomy of Coral

    NSDL National Science Digital Library

    In this activity, students examine hydra, a fresh-water relative of coral, under a microscope to observe feeding behavior and identify stinging cells that are characteristic of corals. They also learn more about the individual animals that make up coral reefs and construct simple models of coral polyp anatomy and feeding behavior.

  12. Human Anatomy II: Circulatory System

    E-print Network

    Brown, Christopher A.

    1 Human Anatomy II: Circulatory System The Cardiovascular System Major functions include) Maintenance of fluid balance Protection against invading organisms Circulatory systems may be open or closed Open circulatory systems allow circulatory fluid to empty out of vessels Closed circulatory systems

  13. How Much Anatomy is Enough?

    NSDL National Science Digital Library

    2008-08-01

    This article describes a study conducted at 8 Dutch Medical Schools investigating the effect of various didactic approaches to teaching anatomy on performance. Outcomes discussed include that good test performance is not related to teaching style, but rather course hours, clinical relevance, and revisiting anatomical concepts.

  14. Classic versus millennial medical lab anatomy.

    PubMed

    Benninger, Brion; Matsler, Nik; Delamarter, Taylor

    2014-10-01

    This study investigated the integration, implementation, and use of cadaver dissection, hospital radiology modalities, surgical tools, and AV technology during a 12-week contemporary anatomy course suggesting a millennial laboratory. The teaching of anatomy has undergone the greatest fluctuation of any of the basic sciences during the past 100 years in order to make room for the meteoric rise in molecular sciences. Classically, anatomy consisted of a 2-year methodical, horizontal, anatomy course; anatomy has now morphed into a 12-week accelerated course in a vertical curriculum, at most institutions. Surface and radiological anatomy is the language for all clinicians regardless of specialty. The objective of this study was to investigate whether integration of full-body dissection anatomy and modern hospital technology, during the anatomy laboratory, could be accomplished in a 12-week anatomy course. Literature search was conducted on anatomy text, journals, and websites regarding contemporary hospital technology integrating multiple image mediums of 37 embalmed cadavers, surgical suite tools and technology, and audio/visual technology. Surgical and radiology professionals were contracted to teach during the anatomy laboratory. Literature search revealed no contemporary studies integrating full-body dissection with hospital technology and behavior. About 37 cadavers were successfully imaged with roentograms, CT, and MRI scans. Students were in favor of the dynamic laboratory consisting of multiple activity sessions occurring simultaneously. Objectively, examination scores proved to be a positive outcome and, subjectively, feedback from students was overwhelmingly positive. Despite the surging molecular based sciences consuming much of the curricula, full-body dissection anatomy is irreplaceable regarding both surface and architectural, radiological anatomy. Radiology should not be a small adjunct to understand full-body dissection, but rather, full-body dissection aids the understanding of radiology mediums. The millennial anatomy dissection laboratory should consist of, at least, 50% radiology integration during full-body dissection. This pilot study is an example of the most comprehensive integration of full-body dissection, radiology, and hospital technology. PMID:24677128

  15. Analysis of hydrogen-bond interaction potentials from the electron density: Integration of NCI regions

    PubMed Central

    Contreras-García, Julia; Yang, Weitao; Johnson, Erin R.

    2013-01-01

    Hydrogen bonds are of crucial relevance to many problems in chemistry biology and materials science. The recently-developed NCI (Non-Covalent Interactions) index enables real-space visualization of both attractive (van der Waals and hydrogen-bonding) and repulsive (steric) interactions based on properties of the electron density It is thus an optimal index to describe the interplay of stabilizing and de-stabilizing contributions that determine stable minima on hydrogen-bonding potential-energy surfaces (PESs). In the framework of density-functional theory energetics are completely determined by the electron density Consequently NCI will be shown to allow quantitative treatment of hydrogen-bond energetics. The evolution of NCI regions along a PES follows a well-behaved pattern which, upon integration of the electron density is capable of mimicking conventional hydrogen-bond interatomic potentials. PMID:21786796

  16. Anatomy adventure: a board game for enhancing understanding of anatomy.

    PubMed

    Anyanwu, Emeka G

    2014-01-01

    Certain negative factors such as fear, loss of concentration and interest in the course, lack of confidence, and undue stress have been associated with the study of anatomy. These are factors most often provoked by the unusually large curriculum, nature of the course, and the psychosocial impact of dissection. As a palliative measure, Anatomy Adventure, a board game on anatomy was designed to reduce some of these pressures, emphasize student centered and collaborative learning styles, and add fun to the process of learning while promoting understanding and retention of the subject. To assess these objectives, 95 out of over 150 medical and dental students who expressed willingness to be part of the study were recruited and divided into a Game group and a Non-game group. A pretest written examination was given to both groups, participants in the Game group were allowed to play the game for ten days, after which a post-test examination was also given. A 20-item questionnaire rated on a three-point scale to access student's perception of the game was given to the game group. The post-test scores of the game group were significantly higher (P?anatomy. PMID:23878076

  17. Anatomy of a Bird

    NASA Astrophysics Data System (ADS)

    2007-12-01

    Using ESO's Very Large Telescope, an international team of astronomers [1] has discovered a stunning rare case of a triple merger of galaxies. This system, which astronomers have dubbed 'The Bird' - albeit it also bears resemblance with a cosmic Tinker Bell - is composed of two massive spiral galaxies and a third irregular galaxy. ESO PR Photo 55a/07 ESO PR Photo 55a/07 The Tinker Bell Triplet The galaxy ESO 593-IG 008, or IRAS 19115-2124, was previously merely known as an interacting pair of galaxies at a distance of 650 million light-years. But surprises were revealed by observations made with the NACO instrument attached to ESO's VLT, which peered through the all-pervasive dust clouds, using adaptive optics to resolve the finest details [2]. Underneath the chaotic appearance of the optical Hubble images - retrieved from the Hubble Space Telescope archive - the NACO images show two unmistakable galaxies, one a barred spiral while the other is more irregular. The surprise lay in the clear identification of a third, clearly separate component, an irregular, yet fairly massive galaxy that seems to be forming stars at a frantic rate. "Examples of mergers of three galaxies of roughly similar sizes are rare," says Petri Väisänen, lead author of the paper reporting the results. "Only the near-infrared VLT observations made it possible to identify the triple merger nature of the system in this case." Because of the resemblance of the system to a bird, the object was dubbed as such, with the 'head' being the third component, and the 'heart' and 'body' making the two major galaxy nuclei in-between of tidal tails, the 'wings'. The latter extend more than 100,000 light-years, or the size of our own Milky Way. ESO PR Photo 55b/07 ESO PR Photo 55b/07 Anatomy of a Bird Subsequent optical spectroscopy with the new Southern African Large Telescope, and archive mid-infrared data from the NASA Spitzer space observatory, confirmed the separate nature of the 'head', but also added further surprises. The 'head' and major parts of the 'Bird' are moving apart at more than 400 km/s (1.4 million km/h!). Observing such high velocities is very rare in merging galaxies. Also, the 'head' appears to be the major source of infrared luminosity in the system, though it is the smallest of the three galaxies. "It seems that NACO has caught the action right at the time of the first high-speed fly-by of the 'head' galaxy through the system consisting of the other two galaxies," says Seppo Mattila, member of the discovery team. "These two galaxies must have met earlier, probably a couple of hundred million years ago." The 'head' is forming stars violently, at a rate of nearly 200 solar masses per year, while the other two galaxies appear to be at a more quiescent epoch of their interaction-induced star formation history. The 'Bird' belongs to the prestigious family of luminous infrared galaxies, with an infrared luminosity nearly one thousand billion times that of the Sun. This family of galaxies has long been thought to signpost important events in galaxy evolution, such as mergers of galaxies, which in turn trigger bursts of star formation, and may eventually lead to the formation of a single elliptical galaxy. The findings presented here are reported in a paper to appear in a future issue of the journal Monthly Notices of the Royal Astronomical Society ("Adaptive optics imaging and optical spectroscopy of a multiple merger in a luminous infrared galaxy", by P. Väisänen" et al.). Note [1]: The team is composed of P. Väisänen, A. Kniazev, D. A. H. Buckley, L. Crause, Y. Hashimoto, N. Loaring, E. Romero-Colmenero, and M. Still (SAAO, South Africa), S. Mattila (Tuorla Observatory, Finland), A. Adamo and G. Östlin (Stockholm University, Sweden), A. Efstathiou (Cyprus College, Nicosia, Cyprus), D. Farrah (Cornell University, USA), P. H. Johansson (Universitäts-Sternwarte München, Germany), E. B. Burgh and K. Nordsieck (University of Wisconsin, USA), P. Lira (Universidad de Chile, Santiago, Chile),

  18. Connecting genomic alterations to cancer biology with proteomics: the NCI Clinical Proteomic Tumor Analysis Consortium.

    PubMed

    Ellis, Matthew J; Gillette, Michael; Carr, Steven A; Paulovich, Amanda G; Smith, Richard D; Rodland, Karin K; Townsend, R Reid; Kinsinger, Christopher; Mesri, Mehdi; Rodriguez, Henry; Liebler, Daniel C

    2013-10-01

    The National Cancer Institute (NCI) Clinical Proteomic Tumor Analysis Consortium is applying the latest generation of proteomic technologies to genomically annotated tumors from The Cancer Genome Atlas (TCGA) program, a joint initiative of the NCI and the National Human Genome Research Institute. By providing a fully integrated accounting of DNA, RNA, and protein abnormalities in individual tumors, these datasets will illuminate the complex relationship between genomic abnormalities and cancer phenotypes, thus producing biologic insights as well as a wave of novel candidate biomarkers and therapeutic targets amenable to verification using targeted mass spectrometry methods. PMID:24124232

  19. Connecting Genomic Alterations to Cancer Biology with Proteomics: The NCI Clinical Proteomic Tumor Analysis Consortium

    PubMed Central

    Ellis, Matthew J.; Gillette, Michael; Carr, Steven A.; Paulovich, Amanda G.; Smith, Richard D.; Rodland, Karin K.; Townsend, R. Reid; Kinsinger, Christopher; Mesri, Mehdi; Rodriguez, Henry; Liebler, Daniel C.

    2013-01-01

    The National Cancer Institute (NCI) Clinical Proteomic Tumor Analysis Consortium (CPTAC) is applying latest generation of proteomic technologies to genomically annotated tumors from The Cancer Genome Atlas (TCGA) program, a joint initiative of the NCI and National Human Genome Research Institute. By providing a fully integrated accounting of DNA, RNA and protein abnormalities in individual tumors, these datasets will illuminate the complex relationship between genomic abnormalities and cancer phenotypes, thus producing biological insights as well as a wave of novel candidate biomarkers and therapeutic targets amenable to verification using targeted mass spectrometry methods. PMID:24124232

  20. Body-Painting: A Tool Which Can Be Used to Teach Surface Anatomy

    PubMed Central

    Nanjundaiah, Komala; Chowdapurkar, Sheshgiri

    2012-01-01

    Introduction The primary method of learning the surface anatomy is by making the students mark structures on mummified bodies. The students feel that learning the surface anatomy on mummified cadavers is not interesting. The present project on learning the surface anatomy through the body painting method was undertaken to evoke interest among the students. Materials and Methods Physiotherapy and dental undergraduate students who volunteered were involved in this study. A few surface anatomy classes were conducted by using the traditional method and a few more by using the body painting exercise. Non toxic body paints of various colours and brushes of different sizes were used for the body painting. Results A feedback was obtained from the students by using a structured questionnaire. The students opined that the body painting method was advantageous to them in learning the human anatomy. They also felt that they could have more practice sessions in any setting other than in the classroom and that they did not need to rely upon the mummified bodies. They described the body painting method as self explanatory, which gave them the feel of live structures. Conclusion This project was successful in achieving its objectives as the students felt that the method was exciting, with lots of fun during the learning. The body painting method was well accepted by the students as an effective method for learning the surface and the clinical anatomy. PMID:23205358

  1. Controlling the vocabulary for anatomy.

    PubMed Central

    Baud, R. H.; Lovis, C.; Rassinoux, A. M.; Ruch, P.; Geissbuhler, A.

    2002-01-01

    When confronted with the representation of human anatomy, natural language processing (NLP) system designers are facing an unsolved and frequent problem: the lack of a suitable global reference. The available sources in electronic format are numerous, but none fits adequately all the constraints and needs of language analysis. These sources are usually incomplete, difficult to use or tailored to specific needs. The anatomist's or ontologist's view does not necessarily match that of the linguist. The purpose of this paper is to review most recognized sources of knowledge in anatomy usable for linguistic analysis. Their potential and limits are emphasized according to this point of view. Focus is given on the role of the consensus work of the International Federation of Associations of Anatomists (IFAA) giving the Terminologia Anatomica. PMID:12463780

  2. AACR 2014: NCI/NIH-Sponsored Session: Large-Scale Genomics Data for the Research Community through the NCI Center for Cancer Genomics

    Cancer.gov

    The NCI’s Center for Cancer Genomics (CCG), which includes the Office of Cancer Genomics and The Cancer Genome Atlas Program Office, provides the research community access to large-scale molecular characterization data, which is largely sequence-based. CCG programs aim to improve patient outcome through identification of valid molecular targets and associated molecular markers (prognostic or diagnostic), in and across diseases investigated, which should ultimately lead to the rapid development of novel, more effective therapies.

  3. [Surgical anatomy of the nose].

    PubMed

    Nguyen, P S; Bardot, J; Duron, J B; Jallut, Y; Aiach, G

    2014-12-01

    Thorough knowledge of the anatomy of the nose is an essential prerequisite for preoperative analysis and the understanding of surgical techniques. Like a tent supported by its frame, the nose is an osteo-chondral structure covered by a peri-chondroperiosteal envelope, muscle and cutaneous covering tissues. For didactic reasons, we have chosen to treat this chapter in the form of comments from eight key configurations that the surgeon should acquire before performing rhinoplasty. PMID:25159815

  4. Anatomy Resources Provided by MCW Libraries Acland's Video Atlas of Human Anatomy, ClinicalKey, LWW Health Library Premium

    E-print Network

    Anatomy Resources Provided by MCW Libraries Acland's Video Atlas of Human Anatomy, ClinicalKey, LWW the library proxy server. Acland's Video Atlas of Human Anatomy Web-based product featuring freshly dissected such as Atlas of Human Anatomy (Netter) and over 20 additional Netter titles, Gray's Anatomy for Students

  5. Anatomy of the infant head

    SciTech Connect

    Bosma, J.F.

    1986-01-01

    This text is mainly an atlas of illustration representing the dissection of the head and upper neck of the infant. It was prepared by the author over a 20-year period. The commentary compares the anatomy of the near-term infant with that of a younger fetus, child, and adult. As the author indicates, the dearth of anatomic information about postnatal anatomic changes represents a considerable handicap to those imaging infants. In part 1 of the book, anatomy is related to physiologic performance involving the pharynx, larynx, and mouth. Sequential topics involve the regional anatomy of the head (excluding the brain), the skeleton of the cranium, the nose, orbit, mouth, larynx, pharynx, and ear. To facilitate use of this text as a reference, the illustrations and text on individual organs are considered separately (i.e., the nose, the orbit, the eye, the mouth, the larynx, the pharynx, and the ear). Each part concerned with a separate organ includes materials from the regional illustrations contained in part 2 and from the skeleton, which is treated in part 3. Also included in a summary of the embryologic and fetal development of the organ.

  6. Hip: Anatomy and US technique

    PubMed Central

    Molini, L.; Precerutti, M.; Gervasio, A.; Draghi, F.; Bianchi, S.

    2011-01-01

    Ultrasound (US) has always had a relatively limited role in the evaluation of the hip due to the deep location of this joint. However, many hip diseases are well detectable at US, but before approaching such a study it is necessary to be thoroughly familiar with the normal anatomy and related US images. The study technique is particularly important as optimization of various parameters is required, such as probe frequency, focalization, positioning of the probe, etc. Also the patient’s position is important, as it varies according to the area requiring examination. For the study of the anterior structures, the patient should be in the supine position; for the medial structures, the leg should be abducted and rotated outward with the knee flexed; for the lateral structures, the patient should be in the controlateral decubitus position; for the posterior structures the patient must be in the prone position. US study of the hip includes assessment of the soft tissues, tendons, ligaments and muscles, and also of the bone structures, joint space and serous bursae. The purpose of this article is to review the normal anatomy of the hip as well as the US anatomy of this joint. PMID:23397030

  7. LEAF ANATOMY OF ORCUTTIEAE (POACEAE: CHLORIDOIDEAE): MORE EVIDENCE OF C4 PHOTOSYNTHESIS WITHOUT KRANZ ANATOMY

    E-print Network

    Pockman, William T.

    LEAF ANATOMY OF ORCUTTIEAE (POACEAE: CHLORIDOIDEAE): MORE EVIDENCE OF C4 PHOTOSYNTHESIS WITHOUT KRANZ ANATOMY LAURA M. BOYKIN1,2,3 , WILLIAM T. POCKMAN1 AND TIMOTHY K. LOWREY1 1 Department of Biology, University of New Mexico, Albuquerque, NM 87131 ABSTRACT C4 photosynthesis without Kranz anatomy (single

  8. The nose and paranasal sinuses physiology and anatomy.

    PubMed

    Jones, N

    2001-09-23

    The paranasal sinuses and nose are much more than two cavities behind a projection on the centre of the face. They humidify, filter, warm, and sense what we breathe. The anatomy and physiology interact forming a dynamic system. The anatomy, airflow, nasal resistance, its turbulence, the nasal cycle - a process by which the turbinates or cushions lining the nose alternatively swell and congest from side to side, can all potentially influence the nasal delivery of drugs. Along with these factors mucus rheology and mucociliary clearance influence the removal of substances delivered to the nose. The health of the nose and its immunological response to what is inhaled, be it pollutants, allergens, drugs or vaccines, all need to be considered. It is a fascinating sensor for the body, not only detecting the potentially harmful substances such as smoke, but its psychosexual aspects have far reaching implications and the olfactory pathway has potential as a pathway for the delivery of drugs. PMID:11516776

  9. [Anatomy of the midface].

    PubMed

    Delmar, H

    2009-10-01

    The middle third of the face comes in three areas: malar, zygomatic and orbital. Its bone's base, essentially formed by the maxilla and the zygoma, shows an orbital edge whose projection is not flat and offers an integration to the arcus marginalis. The orbicularis oculi muscle (OOM), wide muscular sheet, is held by several ligamentary structures, one of which is the orbicularis retaining ligament (ORL), peripheric around the orbit and by malar septa. The two layers of fat, one superficial and one deep, are split by the OOM. The deep malar fat pad (or suborbicularis oculi fat pad [SOOF]) is compact with the tracti that cover it and acts as a syssarcosis. The superficial malar fat pad is thick and divided by retinaculi cutis. It acts as a buffer zone in the interorificial role allowing different functions like the gradation in the comical expression and the wide opening for the mouth prehension. This anatomic disposition complies with Lambros' clinical observations who noticed few cutaneous moves of the malar area. PMID:19717217

  10. NCI's Physician Data Query (PDQ®) cancer information summaries: history, editorial processes, influence, and reach.

    PubMed

    Manrow, Richard E; Beckwith, Margaret; Johnson, Lenora E

    2014-03-01

    In the National Cancer Act of 1971, the Director of the National Cancer Institute (NCI) was given a mandate to "Collect, analyze, and disseminate all data useful in the prevention, diagnosis, and treatment of cancer, including the establishment of an International Cancer Research Data Bank (ICRDB) to collect, catalog, store, and disseminate insofar as feasible the results of cancer research undertaken in any country for the use of any person involved in cancer research in any country" (National Cancer Act of 1971, S 1828, 92nd Congress, 1st Sess (1971)). In subsequent legislation, the audience for NCI's information dissemination activities was expanded to include physicians and other healthcare professionals, patients and their families, and the general public, in addition to cancer researchers. The Institute's response to these legislative requirements was to create what is now known as the Physician Data Query (PDQ®) cancer information database. From its beginnings in 1977 as a database of NCI-sponsored cancer clinical trials, PDQ has grown to include extensive information about cancer treatment, screening, prevention, supportive and palliative care, genetics, drugs, and more. Herein, we describe the history, editorial processes, influence, and global reach of one component of the PDQ database, namely its evidence-based cancer information summaries for health professionals. These summaries are widely recognized as important cancer information and education resources, and they further serve as foundational documents for the development of other cancer information products by NCI and other organizations. PMID:23996204

  11. NCI’s Annual Report on Complementary and Alternative Medicine(CAM)- OCCAM

    Cancer.gov

    Krystle Zuniga, a Ph.D. candidate at University of Illinois at Urbana-Champaign (UI-UC), has always been interested in nutrition and learning how various whole foods can have an impact on cancer prevention. Ms. Zuniga is a recipient of an NCI Ruth L.

  12. El estudio NCI-MATCH vinculará medicamentos dirigidos para el cáncer con anomalías genéticas

    Cancer.gov

    Los investigadores del estudio a nivel nacional NCI-MATCH: Análisis molecular para la elección de tratamientos, anunciaron que el estudio busca determinar la eficacia de los tratamientos dirigidos en personas con tumores que presentan mutaciones genéticas específicas independientemente de su tipo de cáncer.

  13. NCI scientists find protective mechanism against cancer in the cells of progeria patients

    Cancer.gov

    NCI scientists have studied cells of patients with an extremely rare genetic disease that is characterized by drastic premature aging and discovered a new protective cellular mechanism against cancer. They found that cells from patients with Hutchinson Gilford Progeria Syndrome (HGPS), who typically do not develop cancer, contain a tumor protection mechanism that is mediated by BRD4.

  14. Mission — CBIIT: Welcome to the NCI Center for Biomedical Informatics and Information Technology

    Cancer.gov

    The National Cancer Informatics Program (NCIP) supports NCI research initiatives through sustaining a multidisciplinary community of biomedical researchers, informaticists, and developers dedicated to improving informatics practices in the study of cancer and the translation of that knowledge into improved clinical interventions.

  15. NCI Releases Preliminary Data on Genetic Susceptibility for Prostate Cancer | Office of Cancer Genomics

    Cancer.gov

    The National Cancer Institute (NCI), part of the National Institutes of Health, has released new data from the Cancer Genetic Markers of Susceptibility (CGEMS) study on prostate cancer. This information could help identify genetic factors that influence the disease and will be integral to the discovery and development of new, targeted therapies.

  16. NIAID/NCI/NIST Workshop on Radiation Dosimetry Standardization for Radiobiology

    E-print Network

    1 NIAID/NCI/NIST Workshop on Radiation Dosimetry Standardization for Radiobiology September 15 ­ 16 to answer is what are the current requirements in the field with regard to dosimetry PRECISION and ACCURACY for PRECISION and ACCURACY? · Whether human or research animal, there are large biological differences

  17. El papel que desempeña el NCI en la investigación del cáncer

    Cancer.gov

    El Instituto Nacional del Cáncer (NCI) es el patrocinador más grande del mundo de investigaciones sobre el cáncer y financia investigaciones realizadas en el mismo instituto y en centros oncológicos, hospitales, clínicas comunitarias y universidades en Estados Unidos y en todo el mundo.

  18. Centro de Contacto del NCI—Servicio de Información sobre el Cáncer

    Cancer.gov

    El Instituto Nacional del Cáncer (NCI) ofrece información actualizada, precisa, confiable y fácil de entender sobre diferentes de temas de cáncer. Los especialistas en información le pueden ayudar en el teléfono 1-800-422-6237 (1-800-4-CANCER).

  19. NCI’s Center for Global Health announces first major research grants to support portable technologies

    Cancer.gov

    NCI’s Center for Global Health announced grants that will support the development and validation of low-cost, portable technologies. These technologies have the potential to improve early detection, diagnosis, and non-invasive or minimally invasive treatment of several cancer types that have a particularly high prevalence in a number of low- and middle-income countries.

  20. NCI clinician-scientists at the forefront of new prostate cancer diagnostics and treatment

    Cancer.gov

    Introduction of the UroNav was the result of nearly a decade’s research and development, principally conducted at NCI. Resembling a stylized computer workstation on wheels, the system electronically fuses together pictures from magnetic resonance imaging and ultrasound to create a detailed, three-dimensional view of the prostate, which physicians can then use to guide precision biopsies.

  1. NCI Statement on the U.S. Surgeon General's "Call to Action to Prevent Skin Cancer"

    Cancer.gov

    As the Federal Government's principal agency for cancer research and training, the National Cancer Institute (NCI) endorses the U.S. Surgeon General’s “Call to Action to Prevent Skin Cancer,” which provides a comprehensive evaluation of the current state of skin cancer prevention efforts in the United States and recommends actions for improvement in the future.

  2. Aspectos generales de la Red Nacional de Estudios Clínicos del NCI

    Cancer.gov

    Reseña general sobre la estructura organizativa de la Red Nacional de Estudios Clínicos del NCI, así como un resumen de los cambios que se están llevando a cabo y una sinopsis de cómo estos cambios se basan en el éxito del programa de Grupos Cooperativos.

  3. About NExT | NCI Experimental Therapeutics (NExT)

    Cancer.gov

    Skip to Content Search this site ABOUT NExT NCINExTInfo@mail.nih.gov Overview Mission Contacts Last Updated: 03/02/15 Phase 0 - I NExT Projects Applicant Institute Project Dorr, Andrew BioMarin Pharmaceutical Inc Patient Selection Assay Strategies

  4. About NExT | NCI Experimental Therapeutics (NExT)

    Cancer.gov

    Skip to Content Search this site ABOUT NExT NCINExTInfo@mail.nih.gov Overview Mission Contacts Last Updated: 09/25/14 Preclinical Evaluation Stage NExT Projects Applicant Institute Project Cassady, Kevin University of Alabama at Birmingham Production

  5. Anatomy of Ursa Majoris

    NASA Astrophysics Data System (ADS)

    Karachentsev, I. D.; Nasonova, O. G.; Courtois, H. M.

    2013-03-01

    A nearby friable cloud in Ursa Majoris contains 270 galaxies with radial velocities 500 < VLG < 1500 km s-1 inside the area of RA = [11^h. 0, 13^h. 0] and Dec. = [ + 40°, +60°]. At present, 97 galaxies of them have individual distance estimates. We use these data to clarify the structure and kinematics of the UMa complex. According to Makarov & Karachentsev, most of the UMa galaxies belong to seven bound groups, which have the following median parameters: velocity dispersion of 58 km s-1, harmonic projected radius of 300 kpc, virial mass of 2 × 1012 M? and virial mass-to-K-band luminosity ratio of 27 M?/L?. Almost a half of the UMa cloud population are gas-rich dwarfs (Ir, Im, BCD) with active star formation seen in the GALEX UV-survey. The UMa groups reside within 15-19 Mpc from us, being just at the same distance as the Virgo cluster. The total virial mass of the UMa groups is 4 × 1013 M?, yielding the average density of dark matter in the UMa cloud to be ?m = 0.08, i.e. a factor of 3 lower than the cosmic average. This is despite the fact that the UMa cloud resides in a region of the Universe that is an apparent overdensity. A possible explanation for this is that most mass in the Universe lies in the empty space between clusters. Herewith, the mean distances and velocities of the UMa groups follow nearly undisturbed Hubble flow without a sign of the `Z-wave' effect caused by infall towards a massive attractor. This constrains the total amount of dark matter between the UMa groups within the cloud volume.

  6. AUTOMATIC ANATOMY RECOGNITION VIA FUZZY OBJECT Jayaram K. Udupaa

    E-print Network

    Ciesielski, Krzysztof Chris

    AUTOMATIC ANATOMY RECOGNITION VIA FUZZY OBJECT MODELS Jayaram K. Udupaa , Dewey Odhnera , Alexandre radiological practice, computerized automatic anatomy recognition (AAR) during radiological image reading

  7. Screening Services – NCI-60 DTP Human Tumor Cell Line Screen

    Cancer.gov

    The In Vitro Cell Line Screening Project (IVCLSP) is a dedicated service providing direct support to the DTP anticancer drug discovery program. The in vitro cell line screen was implemented in fully operational form in April of 1990. It required approximately five years (1985 - 1990) to develop, and persistence in the effort reflected dissatisfaction with the performance of prior in vivo primary screens. This project is designed to screen up to 3,000 compounds per year for potential anticancer activity.

  8. Anatomy Education Faces Challenges in Pakistan

    ERIC Educational Resources Information Center

    Memon, Ismail K.

    2009-01-01

    Anatomy education in Pakistan is facing many of the same challenges as in other parts of the world. Roughly, a decade ago, all medical and dental colleges in Pakistan emphasized anatomy as a core basic discipline within a traditional medical science curriculum. Now institutions are adopting problem based learning (PBL) teaching philosophies, and…

  9. Cochlear Anatomy of the Alligator Lizard

    Microsoft Academic Search

    Michael J. Mulroy

    1974-01-01

    The anatomy of the peripheral auditory system of the alligator lizard, Gerrhonotus multicarinatus, is described. The histology of the auditory receptor (basilar papilla) is described in detail and compared with the mammalian organ of Corti. Special features of the cochlear anatomy are correlated with intracellular responses recorded within the basilar papilla. The cochlea of the alligator lizard is a suitable

  10. The Development of Spinal Cord Anatomy

    Microsoft Academic Search

    J. M. S. Pearce

    2008-01-01

    A panel illustrating spinal cord injury in The Dying Lioness in the British Museum dates to 650 BC. This paper outlines the subsequent progression of knowledge of the anatomy of the spinal cord. The animal dissections of Galen are considered because his deductions persisted through the Dark Ages until the late 18th century. Anatomy advanced gradually to yield discoveries of

  11. The history and illustration of anatomy in the Middle Ages.

    PubMed

    Gurunluoglu, Raffi; Gurunluoglu, Aslin; Williams, Susan A; Cavdar, Safiye

    2013-11-01

    This article reviews the influence of key figures on the pictorial representation of anatomy and the evolution of anatomical illustration during the Middle Ages until the time of the Renaissance, based on medical history books, journals and ancient medical books. During the early period in the Middle Ages, most illustrations were traditional drawings of emblematic nature, oftentimes unrealistic, not only because the precise knowledge of anatomy was lacking but also because the objective was to elucidate certain principles for teaching purposes. Five figure-series that came down to us through ancient manuscripts and textbooks represent the best examples of such traditional illustrations. With the advent of human dissection in the 13th and 14th centuries, a significant transformation in the depiction of anatomy began to project the practice of human dissection, as we see in the works of Mondino de Luzzi, Henri de Mondeville and Guido de Vigevano. After the invention of book printing in the second half of the 15th century, the reproduction of books was commonly practised and the woodcut made multiplication of pictures easier. Peter of Abano, Hieronymous Brunschwig, Johannes de Ketham, Johannes Peyligk, Gregory Reisch, Magnus Hundt, Laurentius Phryesen and many more included several anatomical illustrations in their treatises that demonstrated the development of anatomical illustration during the later Middle Ages. PMID:24585828

  12. The development, assessment and validation of virtual reality for human anatomy instruction

    NASA Technical Reports Server (NTRS)

    Marshall, Karen Benn

    1996-01-01

    This research project seeks to meet the objective of science training by developing, assessing, validating and utilizing VR as a human anatomy training medium. Current anatomy instruction is primarily in the form of lectures and usage of textbooks. In ideal situations, anatomic models, computer-based instruction, and cadaver dissection are utilized to augment traditional methods of instruction. At many institutions, lack of financial resources limits anatomy instruction to textbooks and lectures. However, human anatomy is three-dimensional, unlike the one-dimensional depiction found in textbooks and the two-dimensional depiction found on the computer. Virtual reality allows one to step through the computer screen into a 3-D artificial world. The primary objective of this project is to produce a virtual reality application of the abdominopelvic region of a human cadaver that can be taken back to the classroom. The hypothesis is that an immersive learning environment affords quicker anatomic recognition and orientation and a greater level of retention in human anatomy instruction. The goal is to augment not replace traditional modes of instruction.

  13. NCI QuitPal, an App from the National Cancer Institute | NIH MedlinePlus the Magazine

    MedlinePLUS

    ... turn Javascript on. NCI QuitPal, an App from the National Cancer Institute Past Issues / Winter 2013 Table ... Institutes of Health National Cancer Institute What if the tools you need to quit smoking were as ...

  14. COMPARATIVE WOOD ANATOMY OF PERENNIAL SHOOTS OF POTENTILLA (ROSACEAE)

    Microsoft Academic Search

    A. Stepanova; E. S. Chavchavadze; S. Jansen

    2007-01-01

    SUMMARY The wood anatomy of perennial shoots of 26 Potentilla species was studied using light and scanning electron microscopy. Secondary xylem of different growth forms was compared. The wood anatomy of perennial shoots of Potentilla species with growth forms intermediate between shrubs and herbs (except P. biflora and P. palustris) is similar to the wood anatomy of shrubs. Wood anatomy

  15. GASTROINTESTINAL ANATOMY Fig. 171. Longitudinal section through the liver

    E-print Network

    GASTROINTESTINAL ANATOMY Fig. 171. Longitudinal section through the liver and gallbladder gallbladder gallbladder bile duct ampulla of Vater (bile duct papilla) duodenum pylorus duodenum The Anatomy of Sea Turtles 113 #12;The Anatomy of Sea Turtles114 GASTROINTESTINAL ANATOMY Figs. 172a and 172b

  16. THE ANATOMY OF INTEGERS AND PERMUTATIONS Andrew Granville

    E-print Network

    Granville, Andrew

    THE ANATOMY OF INTEGERS AND PERMUTATIONS Andrew Granville We begin, as in any mathematical paper, with definitions: Anatomy (a-nat-o-my) noun: The scientific study of the shape and structure of an organism together a forensic team to investigate the anatomy of some of the most common mathematical objects, say

  17. Abstracting and Generalising the Foundational Model Anatomy (FMA) Ontology

    E-print Network

    Stevens, Robert

    of Anatomy (FMA) is a highly detailed reference ontology representing the human anatomy from a developmental1 Abstracting and Generalising the Foundational Model Anatomy (FMA) Ontology Eleni Mikroyannidi Motivation: The Foundational Model of Anatomy (FMA) is arguably the largest and most complete ontology

  18. INTEGRATING GENOMIC KNOWLEDGE SOURCES THROUGH AN ANATOMY ONTOLOGY

    E-print Network

    Yetisgen-Yildiz, Meliha

    expression experiments. We present two examples where we have combined a large ontology of human anatomy (theINTEGRATING GENOMIC KNOWLEDGE SOURCES THROUGH AN ANATOMY ONTOLOGY JOHN H. GENNARI, ADAM SILBERFEIN that one way to integrate multiple knowledge sources is through anatomy--both generic cellular anatomy

  19. Identification of Two Nickel Ion-Induced Genes, NCI16 and PcGST1, in Paramecium caudatum

    PubMed Central

    Haga, Nobuyuki; Nakano, Takanari; Ikeda, Masaaki; Katayama, Shigehiro; Awata, Takuya

    2014-01-01

    Here, we describe the isolation of two nickel-induced genes in Paramecium caudatum, NCI16 and PcGST1, by subtractive hybridization. NCI16 encoded a predicted four-transmembrane domain protein (?16 kDa) of unknown function, and PcGST1 encoded glutathione S-transferase (GST; ?25 kDa) with GST and glutathione peroxidase (GPx) activities. Exposing cells to cobalt chloride also caused the moderate upregulation of NCI16 and PcGST1 mRNAs. Both nickel sulfate and cobalt chloride dose dependently induced NCI16 and PcGST1 mRNAs, but with different profiles. Nickel treatment caused a continuous increase in PcGST1 and NCI16 mRNA levels for up to 3 and 6 days, respectively, and a notable increase in H2O2 concentrations in P. caudatum. NCI16 expression was significantly enhanced by incubating cells with H2O2, implying that NCI16 induction in the presence of nickel ions is caused by reactive oxygen species (ROS). On the other hand, PcGST1 was highly induced by the antioxidant tert-butylhydroquinone (tBHQ) but not by H2O2, suggesting that different mechanisms mediate the induction of NCI16 and PcGST1. We introduced a luciferase reporter vector with an ?0.42-kb putative PcGST1 promoter into cells and then exposed the transformants to nickel sulfate. This resulted in significant luciferase upregulation, indicating that the putative PcGST1 promoter contains a nickel-responsive element. Our nickel-inducible system also may be applicable to the efficient expression of proteins that are toxic to host cells or require temporal control. PMID:25001407

  20. Living anatomy in the 21st century: how far can we go?

    Microsoft Academic Search

    Pallab K Ganguly; Lap Ki Chan

    Living anatomy, defined as the anatomy revealed on living humans, is gaining importance in modern anatomy education, and has even been considered to replace cadaver-based anatomy study. We discussed the modalities through which living anatomy can be studied and explore the feasibility of using them to replace cadaver-based anatomy. We believe that the study of anatomy via the three main

  1. NCI’s Annual Report on Complementary and Alternative Medicine(CAM)- OCCAM

    Cancer.gov

    The NCI Polyp Prevention Trial (PPT) was a multicenter, randomized clinical trial, with almost 2,000 individuals, that tested whether a diet (high-fiber, low-fat, and high in fruits and vegetables) could prevent the recurrence of precancerous adenomas (polyps) in the colon and rectum. However, the researchers found no preventive effect of the healthy diet on polyp recurrence, even after long-term follow up.

  2. The NCI’s Cancer Information Service staff training program: A foundation for excellence

    Microsoft Academic Search

    Rosemarie Slevin Perocchia; Annette Galassi; Randy Jacobs; Nancy Krauss; K. Kim LeMaitre; Sue Rutledge

    2007-01-01

    The philosophy of the National Cancer Institute’s (NCI) Cancer Information Service (CIS) staff training program is based on\\u000a the premise that a solid relationship exists between staff performance and training. As a leading edge organization and the\\u000a premiere cancer information service in the world, the CIS provides more training to its staff than many organizations. This\\u000a factor is in part

  3. NCI Launches New Initiative to Identify Genetic Risk Factors for Breast and Prostate Cancer

    Cancer.gov

    The National Cancer Institute (NCI), part of the National Institutes of Health, today launched an initiative to identify genetic alterations that make people susceptible to prostate and breast cancer, two of the most commonly diagnosed cancers in the United States. Cancer Genetic Markers of Susceptibility (CGEMS) is a three-year initiative, funded for $14 million, that will conduct scans of the entire human genome (genotyping) to identify common, inherited gene mutations that increase the risks for breast and prostate cancer.

  4. Expression of MicroRNAs in the NCI-60 Cancer Cell-Lines

    PubMed Central

    Patnaik, Santosh K.; Dahlgaard, Jesper; Mazin, Wiktor; Kannisto, Eric; Jensen, Thomas; Knudsen, Steen; Yendamuri, Sai

    2012-01-01

    The NCI-60 panel of 60 human cancer cell-lines of nine different tissues of origin has been extensively characterized in biological, molecular and pharmacological studies. Analyses of data from such studies have provided valuable information for understanding cellular processes and developing strategies for the diagnosis and treatment of cancer. Here, Affymetrix® GeneChip™ miRNA version 1 oligonucleotide microarrays were used to quantify 847 microRNAs to generate an expression dataset of 495 (58.4%) microRNAs that were identified as expressed in at least one cell-line of the NCI-60 panel. Accuracy of the microRNA measurements was partly confirmed by reverse transcription and polymerase chain reaction assays. Similar to that seen among the four existing NCI-60 microRNA datasets, the concordance of the new expression dataset with the other four was modest, with mean Pearson correlation coefficients of 0.37–0.54. In spite of this, comparable results with different datasets were noted in clustering of the cell-lines by their microRNA expression, differential expression of microRNAs by the lines’ tissue of origin, and correlation of specific microRNAs with the doubling-time of cells or their radiation sensitivity. Mutation status of the cell-lines for the TP53, PTEN and BRAF but not CDKN2A or KRAS cancer-related genes was found to be associated with changes in expression of specific microRNAs. The microRNA dataset generated here should be valuable to those working in the field of microRNAs as well as in integromic studies of the NCI-60 panel. PMID:23209617

  5. Expression of microRNAs in the NCI-60 cancer cell-lines.

    PubMed

    Patnaik, Santosh K; Dahlgaard, Jesper; Mazin, Wiktor; Kannisto, Eric; Jensen, Thomas; Knudsen, Steen; Yendamuri, Sai

    2012-01-01

    The NCI-60 panel of 60 human cancer cell-lines of nine different tissues of origin has been extensively characterized in biological, molecular and pharmacological studies. Analyses of data from such studies have provided valuable information for understanding cellular processes and developing strategies for the diagnosis and treatment of cancer. Here, Affymetrix® GeneChip™ miRNA version 1 oligonucleotide microarrays were used to quantify 847 microRNAs to generate an expression dataset of 495 (58.4%) microRNAs that were identified as expressed in at least one cell-line of the NCI-60 panel. Accuracy of the microRNA measurements was partly confirmed by reverse transcription and polymerase chain reaction assays. Similar to that seen among the four existing NCI-60 microRNA datasets, the concordance of the new expression dataset with the other four was modest, with mean Pearson correlation coefficients of 0.37-0.54. In spite of this, comparable results with different datasets were noted in clustering of the cell-lines by their microRNA expression, differential expression of microRNAs by the lines' tissue of origin, and correlation of specific microRNAs with the doubling-time of cells or their radiation sensitivity. Mutation status of the cell-lines for the TP53, PTEN and BRAF but not CDKN2A or KRAS cancer-related genes was found to be associated with changes in expression of specific microRNAs. The microRNA dataset generated here should be valuable to those working in the field of microRNAs as well as in integromic studies of the NCI-60 panel. PMID:23209617

  6. NCI Issues and Expands the Cancer Trends Progress Report: 2009/2010 Update

    Cancer.gov

    The NCI released the Cancer Trends Progress Report: 2009/2010 Update. The report, which spans the cancer control continuum from prevention through end of life and summarizes our nation's progress against cancer in relation to the Healthy People  targets developed by the U.S. Department of Health and Human Services, has expanded its focus in this year’s update to include additional info on Medicaid, tobacco marketing, the cost of cancer and other topics.

  7. Development of Community College Instructional Modules for Biology and Comparative Vertebrate Anatomy.

    ERIC Educational Resources Information Center

    Vasiliauskas, Jura B.

    A project was undertaken to: (1) formulate objectives for a biology unit dealing with frog dissection and vertebrate anatomy, (2) on the basis of these objectives, develop self-instructional modules utilizing audio-visual and printed instructional materials, and (3) formulate instruments for the evaluation of the modules. The rationale for the…

  8. Book Review: Megaprojects and Risk: An Anatomy of Ambition by Bent Flyvbjerg, Nils Bruzelius

    E-print Network

    Levinson, David M.

    Book Review: Megaprojects and Risk: An Anatomy of Ambition by Bent Flyvbjerg, Nils Bruzelius and David Luberoff Two recent books on the development and deployment of large projects have recently been released. Both books tackle Megaprojects, but from somewhat different points- of-view, one European

  9. Art, antiquarianism and early anatomy.

    PubMed

    Guest, Clare E L

    2014-12-01

    Discussions of the early relationship between art and anatomy are shaped by Vasari's account of Florentine artists who dissected bodies in order to understand the causes of movement, and the end of movement in action. This account eclipses the role of the study of antiquities in Renaissance anatomical illustration. Beyond techniques of presentation, such as sectioning and analytic illustration, or a preoccupation with the mutilated fragment, antiquarianism offered a reflection on the variant and the role of temperament which could be adapted for anatomical purposes. With its play on ambiguities of life and death, idealisation and damage, antiquarianism also provided a way of negotiating the difficulties of content inherent in anatomical illustration. As such, it goes beyond exclusively historical interest to provoke reflection on the modes, possibilities and humane responsibilities of medical illustration. PMID:24696510

  10. In praise of tedious anatomy

    PubMed Central

    Devlin, Joseph T.; Poldrack, Russell A.

    2006-01-01

    Functional neuroimaging is fundamentally a tool for mapping function to structure, and its success consequently requires neuroanatomical precision and accuracy. Here we review the various means by which functional activation can be localized to neuroanatomy and suggest that the gold standard should be localization to the individual’s or group’s own anatomy through the use of neuroanatomical knowledge and atlases of neuroanatomy. While automated means of localization may be useful, they cannot provide the necessary accuracy, given variability between individuals. We also suggest that the field of functional neuroimaging needs to converge on a common set of methods for reporting functional localization including a common “standard” space and criteria for what constitutes sufficient evidence to report activation in terms of Brodmann’s areas. PMID:17870621

  11. An atlas of radiological anatomy

    SciTech Connect

    Weir, J.; Abrahams, P.

    1986-01-01

    This book contains a wealth of radiologic images of normal human anatomy; plain radiographs, contrast-enhanced radiographs, and computed tomography (CT) scans. There are 18 pages of magnetic resonance (MR) images, most on the brain and spinal cord, so that there are only two pages on MR imaging of the heart and two pages on abdominal and pelvic MR imaging. Twelve pages of ultrasound (US) images are included. This book has the radiologic image paired with an explanatory drawing; the image is on the left with a paragraph or two of text, and the drawing is on the right with legends. This book includes images of the brain and spinal cord obtained with arteriography, venography, myelography, encephalography, CT, and MR imaging.

  12. Providing visualisation support for the analysis of anatomy ontology data

    PubMed Central

    Dadzie, Aba-Sah; Burger, Albert

    2005-01-01

    Background Improvements in technology have been accompanied by the generation of large amounts of complex data. This same technology must be harnessed effectively if the knowledge stored within the data is to be retrieved. Storing data in ontologies aids its management; ontologies serve as controlled vocabularies that promote data exchange and re-use, improving analysis. The Edinburgh Mouse Atlas Project stores the developmental stages of the mouse embryo in anatomy ontologies. This project is looking at the use of visual data overviews for intuitive analysis of the ontology data. Results A prototype has been developed that visualises the ontologies using directed acyclic graphs in two dimensions, with the ability to study detail in regions of interest in isolation or within the context of the overview. This is followed by the development of a technique that layers individual anatomy ontologies in three-dimensional space, so that relationships across multiple data sets may be mapped using physical links drawn along the third axis. Conclusion Usability evaluations of the applications confirmed advantages in visual analysis of complex data. This project will look next at data input from multiple sources, and continue to develop the techniques presented to provide intuitive identification of relationships that span multiple ontologies. PMID:15790390

  13. The NCI Alliance for Nanotechnology in Cancer: achievement and path forward.

    PubMed

    Ptak, Krzysztof; Farrell, Dorothy; Panaro, Nicholas J; Grodzinski, Piotr; Barker, Anna D

    2010-01-01

    Nanotechnology is a 'disruptive technology', which can lead to a generation of new diagnostic and therapeutic products, resulting in dramatically improved cancer outcomes. The National Cancer Institute (NCI) of National Institutes of Health explores innovative approaches to multidisciplinary research allowing for a convergence of molecular biology, oncology, physics, chemistry, and engineering and leading to the development of clinically worthy technological approaches. These initiatives include programmatic efforts to enable nanotechnology as a driver of advances in clinical oncology and cancer research, known collectively as the NCI Alliance for Nanotechnology in Cancer (ANC). Over the last 5 years, ANC has demonstrated that multidisciplinary approach catalyzes scientific developments and advances clinical translation in cancer nanotechnology. The research conducted by ANC members has improved diagnostic assays and imaging agents, leading to the development of point-of-care diagnostics, identification and validation of numerous biomarkers for novel diagnostic assays, and the development of multifunctional agents for imaging and therapy. Numerous nanotechnology-based technologies developed by ANC researchers are entering clinical trials. NCI has re-issued ANC program for next 5 years signaling that it continues to have high expectations for cancer nanotechnology's impact on clinical practice. The goals of the next phase will be to broaden access to cancer nanotechnology research through greater clinical translation and outreach to the patient and clinical communities and to support development of entirely new models of cancer care. PMID:20552623

  14. High precision anatomy for MEG?

    PubMed Central

    Troebinger, Luzia; López, José David; Lutti, Antoine; Bradbury, David; Bestmann, Sven; Barnes, Gareth

    2014-01-01

    Precise MEG estimates of neuronal current flow are undermined by uncertain knowledge of the head location with respect to the MEG sensors. This is either due to head movements within the scanning session or systematic errors in co-registration to anatomy. Here we show how such errors can be minimized using subject-specific head-casts produced using 3D printing technology. The casts fit the scalp of the subject internally and the inside of the MEG dewar externally, reducing within session and between session head movements. Systematic errors in matching to MRI coordinate system are also reduced through the use of MRI-visible fiducial markers placed on the same cast. Bootstrap estimates of absolute co-registration error were of the order of 1 mm. Estimates of relative co-registration error were < 1.5 mm between sessions. We corroborated these scalp based estimates by looking at the MEG data recorded over a 6 month period. We found that the between session sensor variability of the subject's evoked response was of the order of the within session noise, showing no appreciable noise due to between-session movement. Simulations suggest that the between-session sensor level amplitude SNR improved by a factor of 5 over conventional strategies. We show that at this level of coregistration accuracy there is strong evidence for anatomical models based on the individual rather than canonical anatomy; but that this advantage disappears for errors of greater than 5 mm. This work paves the way for source reconstruction methods which can exploit very high SNR signals and accurate anatomical models; and also significantly increases the sensitivity of longitudinal studies with MEG. PMID:23911673

  15. The human anatomy teacher-scholar: Meeting the expectations of educational outcomes research, course content innovation, and textbook innovation for educational scholarship

    NASA Astrophysics Data System (ADS)

    Eckel, Christine Marie

    A human anatomy teacher-scholar is a scholar whose area of expertise includes content knowledge of the anatomical sciences (gross anatomy, histology, embryology, and/or neuroanatomy) and whose research interests and focus are centered in medical educational outcomes. The projects described in this dissertation represent endeavors I engaged in to become a human anatomy teacher-scholar. These projects included: (1) prospectively testing a hypothesis, and performing outcomes assessment in a field for which little data (theory) exist (dissection guide educational research project), (2) creating innovative course content that bridged disciplines (cadaver autopsy project), and (3) composing original teaching material for a specific audience (human anatomy laboratory manual). The training of a human anatomy teacher-scholar emphasizes knowledge acquisition in both the basic sciences (particularly gross anatomy) and in educational outcomes research methodology and theory. Therefore, human anatomy teacher-scholars are positioned to create innovative course content and materials and assess the innovations to guide future efforts. These are important skills for faculty members involved in the education of medical students in the U.S. as the medical education system in the U.S. continues to evolve.

  16. BOLD Granger Causality Reflects Vascular Anatomy

    PubMed Central

    Webb, J. Taylor; Ferguson, Michael A.; Nielsen, Jared A.; Anderson, Jeffrey S.

    2013-01-01

    A number of studies have tried to exploit subtle phase differences in BOLD time series to resolve the order of sequential activation of brain regions, or more generally the ability of signal in one region to predict subsequent signal in another region. More recently, such lag-based measures have been applied to investigate directed functional connectivity, although this application has been controversial. We attempted to use large publicly available datasets (FCON 1000, ADHD 200, Human Connectome Project) to determine whether consistent spatial patterns of Granger Causality are observed in typical fMRI data. For BOLD datasets from 1,240 typically developing subjects ages 7–40, we measured Granger causality between time series for every pair of 7,266 spherical ROIs covering the gray matter and 264 seed ROIs at hubs of the brain’s functional network architecture. Granger causality estimates were strongly reproducible for connections in a test and replication sample (n=620 subjects for each group), as well as in data from a single subject scanned repeatedly, both during resting and passive video viewing. The same effect was even stronger in high temporal resolution fMRI data from the Human Connectome Project, and was observed independently in data collected during performance of 7 task paradigms. The spatial distribution of Granger causality reflected vascular anatomy with a progression from Granger causality sources, in Circle of Willis arterial inflow distributions, to sinks, near large venous vascular structures such as dural venous sinuses and at the periphery of the brain. Attempts to resolve BOLD phase differences with Granger causality should consider the possibility of reproducible vascular confounds, a problem that is independent of the known regional variability of the hemodynamic response. PMID:24349569

  17. Molecular Cell Biology Cell Biology and Anatomy ----------------------------------------------------------------------------

    E-print Network

    Miyashita, Yasushi

    Molecular Cell Biology A G C T 14 Cell Biology and Anatomy associated proteins (MAPs) using molecular cell biology, biophysics, structural biology, and molecular genetics. ·Molecular cell biological study of KIFs ·Studies of the mechanism for recognition of and binding

  18. Professional Storytelling in Clinical Dental Anatomy Teaching

    NSDL National Science Digital Library

    2008-03-31

    This article describes a study in a clinical dental anatomy course exploring the effects of storytelling and problem based learning on student satisfaction. The article explains potential reasons as to why this method demonstrated improved satisfaction among students.

  19. Curricular Guidelines for Teaching Dental Anatomy.

    ERIC Educational Resources Information Center

    Okeson, Jeffrey; Buckman, James

    1981-01-01

    Guidelines developed by the Section on Dental Anatomy and Occlusion of the American Association of Dental Schools for use by individual educational institutions as curriculum development aids are provided. (MLW)

  20. CPR Instruction in a Human Anatomy Class.

    ERIC Educational Resources Information Center

    Lutton, Lewis M.

    1978-01-01

    Describes how cardiopulmonary resuscitation (CPR) instruction can be included in a college anatomy and physiology course. Equipment and instructors are provided locally by the Red Cross or American Heart Association. (MA)

  1. Human Anatomy Biol 253 4 basic types

    E-print Network

    Houde, Peter

    endocrine - ductless exocrine - ducts Connective Tissue loose connective tissue areolar adipose reticular dense connective tissue regular irregular elastic cartilage hyaline elastic fibrous bone blood MuscleHuman Anatomy Biol 253 Tissues 4 basic types epithelial - basement membrane, one free surface

  2. Nurses Need Anatomy and Physiology for....?

    NSDL National Science Digital Library

    PhD Patricia S. Bowne (Alverno College Biology)

    2009-12-01

    A look at whether or not nursing students should take Anatomy and Physiology. Focusing on assessment, this resource describes seven situations where understanding how to take a pulse correlates to A & P.

  3. The IUPS Physiome Project

    Microsoft Academic Search

    P. J. Hunter

    2007-01-01

    Summary form only given. The Physiome Project of the International Union of Physiological Sciences (IUPS) is attempting to provide a comprehensive framework for modelling the physiology of the human body using multi-scale computational methods which can incorporate the biochemistry, biophysics and anatomy of cells, tissues and organs. A major goal of the project is to use computational modelling to analyse

  4. NON Community Networks Program Centers (CNPC) and NCI Community Oncology Research Program (NCORP) Projects

    Cancer.gov

    Strengthen the use of evidence-based education, outreach, and dissemination using the Community Guide, as well as partnership and capacity building, to improve knowledge, behavior, attitude, and beliefs with focus on the early detection of breast, cervical, and colorectal cancers, clinical trial and biospecimen research.

  5. Auditory pathways: anatomy and physiology.

    PubMed

    Pickles, James O

    2015-01-01

    This chapter outlines the anatomy and physiology of the auditory pathways. After a brief analysis of the external, middle ears, and cochlea, the responses of auditory nerve fibers are described. The central nervous system is analyzed in more detail. A scheme is provided to help understand the complex and multiple auditory pathways running through the brainstem. The multiple pathways are based on the need to preserve accurate timing while extracting complex spectral patterns in the auditory input. The auditory nerve fibers branch to give two pathways, a ventral sound-localizing stream, and a dorsal mainly pattern recognition stream, which innervate the different divisions of the cochlear nucleus. The outputs of the two streams, with their two types of analysis, are progressively combined in the inferior colliculus and onwards, to produce the representation of what can be called the "auditory objects" in the external world. The progressive extraction of critical features in the auditory stimulus in the different levels of the central auditory system, from cochlear nucleus to auditory cortex, is described. In addition, the auditory centrifugal system, running from cortex in multiple stages to the organ of Corti of the cochlea, is described. PMID:25726260

  6. Molecular Anatomy of Palate Development

    PubMed Central

    Potter, Andrew S.; Potter, S. Steven

    2015-01-01

    The NIH FACEBASE consortium was established in part to create a central resource for craniofacial researchers. One purpose is to provide a molecular anatomy of craniofacial development. To this end we have used a combination of laser capture microdissection and RNA-Seq to define the gene expression programs driving development of the murine palate. We focused on the E14.5 palate, soon after medial fusion of the two palatal shelves. The palate was divided into multiple compartments, including both medial and lateral, as well as oral and nasal, for both the anterior and posterior domains. A total of 25 RNA-Seq datasets were generated. The results provide a comprehensive view of the region specific expression of all transcription factors, growth factors and receptors. Paracrine interactions can be inferred from flanking compartment growth factor/receptor expression patterns. The results are validated primarily through very high concordance with extensive previously published gene expression data for the developing palate. In addition selected immunostain validations were carried out. In conclusion, this report provides an RNA-Seq based atlas of gene expression patterns driving palate development at microanatomic resolution. This FACEBASE resource is designed to promote discovery by the craniofacial research community. PMID:26168040

  7. Smooth extrapolation of unknown anatomy via statistical shape models

    NASA Astrophysics Data System (ADS)

    Grupp, R. B.; Chiang, H.; Otake, Y.; Murphy, R. J.; Gordon, C. R.; Armand, M.; Taylor, R. H.

    2015-03-01

    Several methods to perform extrapolation of unknown anatomy were evaluated. The primary application is to enhance surgical procedures that may use partial medical images or medical images of incomplete anatomy. Le Fort-based, face-jaw-teeth transplant is one such procedure. From CT data of 36 skulls and 21 mandibles separate Statistical Shape Models of the anatomical surfaces were created. Using the Statistical Shape Models, incomplete surfaces were projected to obtain complete surface estimates. The surface estimates exhibit non-zero error in regions where the true surface is known; it is desirable to keep the true surface and seamlessly merge the estimated unknown surface. Existing extrapolation techniques produce non-smooth transitions from the true surface to the estimated surface, resulting in additional error and a less aesthetically pleasing result. The three extrapolation techniques evaluated were: copying and pasting of the surface estimate (non-smooth baseline), a feathering between the patient surface and surface estimate, and an estimate generated via a Thin Plate Spline trained from displacements between the surface estimate and corresponding vertices of the known patient surface. Feathering and Thin Plate Spline approaches both yielded smooth transitions. However, feathering corrupted known vertex values. Leave-one-out analyses were conducted, with 5% to 50% of known anatomy removed from the left-out patient and estimated via the proposed approaches. The Thin Plate Spline approach yielded smaller errors than the other two approaches, with an average vertex error improvement of 1.46 mm and 1.38 mm for the skull and mandible respectively, over the baseline approach.

  8. DTP - Submission Of Pure Compounds For Testing In The NCI Screens

    Cancer.gov

    The Developmental Therapeutics Program (DTP) operates a tiered anti-cancer compound screening program for the benefit of the general research community with the goal of identifying novel chemical leads and biological mechanisms. The program, which includes the NCI 60-Cell Line Screen and operates at no cost to suppliers of compounds, encourages the submission of synthetic compounds and purified natural products from academic, public and private sources worldwide. Select non-viral biological agents may also be considered for screening by special request (see below).

  9. Tenure Track Faculty Positions in Neuroscience Department of Anatomy & Neurobiology

    E-print Network

    Pillow, Jonathan

    ! ! Tenure Track Faculty Positions in Neuroscience Department of Anatomy & Neurobiology The Department of Anatomy & Neurobiology at Washington University School of Medicine is undergoing a major of neuroscience: 1) Cellular and Molecular Neurobiology including cellular and signaling mechanisms regulating

  10. Dilated Canine Hearts: A Specimen For Teaching Cardiac Anatomy

    NSDL National Science Digital Library

    Dr. Lee Anne Cope (Winthrop University)

    2008-09-01

    This article describes an alternate mechanism for teaching cardiovascular anatomy using dilated canine hearts. The article describes the methodology and academic benefits of using canine hearts in an anatomy laboratory.

  11. The Anatomy Competence Score - A New Marker for Anatomical Ability

    NSDL National Science Digital Library

    2011-11-29

    This articles describes the development of the Anatomy Competence Score (ACS), which incorporates the three domains of anatomy teaching and assessment namely: theoretical knowledge, practical 3D application of the knowledge, and clinical or bedside application of knowledge on patients.

  12. WebAnatomy: Drill and Kill at Will

    NSDL National Science Digital Library

    Murray Jensen (University of Minnesota)

    2008-05-01

    A breakdown and explanation of WebAnatomy; an online way to learn and review Anatomy using four domains: self-test activities, timed-tests, Jeopardy-like games, and an image bank with a wide array of structures.

  13. Isolation and description of a stable carbazole-degrading microbial consortium consisting of Chryseobacterium sp. NCY and Achromobacter sp. NCW.

    PubMed

    Guo, Weiqiang; Li, Daping; Tao, Yong; Gao, Ping; Hu, Jijun

    2008-09-01

    A stable microbial consortium, separated from a refinery wastewater sample, was able to utilize carbazole as the sole source of carbon, nitrogen, and energy, and liberated ammonia from excess nitrogen. Two bacterial strains (NCY and NCW) were isolated from the microbial consortium using a nutrient agar plate. Based on the 16S rDNA sequence analysis, the two bacteria were identified as Chryseobacterium sp. NCY and Achromobacter sp. NCW, respectively. No intermediates of carbazole degradation were detected by high-performance liquid chromatography. The substrate specificity assay showed that the consortium could utilize compounds similar to carbazole, such as phenanthrene, naphthalene, and imidazole. Neither the pure strain NCY nor NCW could degrade carbazole after domestication for several times. It was suggested that the two bacteria formed a microbial consortium capable of metabolizing carbazole. PMID:18584242

  14. A powerful way of teaching anatomy.

    PubMed

    Mavridis, Ioannis N

    2013-05-01

    I read the article entitled "A plea for the use of drawing in human anatomy teaching", by Clavert et al. with great interest. I was glad to read that, in France, anatomy is initially taught by building each structure or region on a blackboard with colored chalk. I find this method quite efficient for this purpose. I believe that drawing is a powerful way of teaching anatomy and therefore the blackboard deserves its rightful place beside other 'high-tech' media. I agree with the authors that the blackboard and the chalk constitute wonderful and powerful educational media, and that appropriate simplification and transposing (of anatomical information) in daily practice are necessary for a sufficient educational result. Among other 'modern' media, movies of surgical procedures could easily attract the students' attention. PMID:23180394

  15. Teaching Anatomy and Physiology Using Computer-Based, Stereoscopic Images

    NSDL National Science Digital Library

    David Kuehn

    2007-01-01

    Learning real three-dimensional (3D) anatomy for the first time can be challenging. Two dimensional drawings and plastic models tend to over-simplify the complexity of anatomy. The approach described uses stereoscopy to create 3D images of the process of cadaver dissection and to demonstrate the underlying anatomy related to the speech mechanisms.

  16. Cours de botanique : niveau 3 ANATOMIE ET COLOGIE DES VGTAUX

    E-print Network

    Cours de botanique : niveau 3 ANATOMIE ET ÉCOLOGIE DES VÉGÉTAUX SERVICE DES FORMATIONS PAYANTES la morphologie, l'anatomie, l'écologie végétale et l'évolution des plantes et leur adaptation, par la.2 Morpho-anatomie et applications 3 nov. 2014 1.2 a Palynologie J. Dejax 17 nov 2014 1.2b les tissus de la

  17. A Physics Based Method for Combining Multiple Anatomy Models with

    E-print Network

    Magee, Derek

    alignment, component replacement, and component insertion. Keywords. Virtual anatomy, medical simulationA Physics Based Method for Combining Multiple Anatomy Models with Application to Medical Simulation, UK Abstract. We present a physics based approach to the construction of anatomy models by combining

  18. Human Hand Modeling from Surface Anatomy Taehyun Rhee

    E-print Network

    Shahabi, Cyrus

    Human Hand Modeling from Surface Anatomy Taehyun Rhee University of Southern California Ulrich surface anatomy: (a) palm creases extracted using tensor voting and surface anatomy, (b) estimated hand The human hand is an important interface with complex shape and movement. In virtual reality and gaming

  19. Anatomy Transfer Dicko Ali-Hamadi1,2,3

    E-print Network

    Plotkin, Joshua B.

    Anatomy Transfer Dicko Ali-Hamadi1,2,3 Tiantian Liu4 Benjamin Gilles5,1 Ladislav Kavan4 Franc University of Pennsylvania 5 LIRMM-CNRS Figure 1: A reference anatomy (left) is automatically transferred with anatomical rules. Abstract Characters with precise internal anatomy are important in film and visual effects

  20. Anatomy of a Shows the 9 components of

    E-print Network

    Venditti, Jeremy G.

    Anatomy of a Hillslope Shows the 9 components of hillslopes and the dominant transport processes and pathways Handout #12;Anatomy of a Hillslope Dominated by vertical soil formation processes Shows the 9 components of hillslopes and the dominant transport processes and pathways #12;Anatomy of a Hillslope

  1. EEB 240: HUMAN ANATOMY THE UNIVERSITY OF TENNESSEE KNOXVILLE

    E-print Network

    Auerbach, Benjamin M.

    1 EEB 240: HUMAN ANATOMY THE UNIVERSITY OF TENNESSEE ­ KNOXVILLE FALL 2013 Instructor: Dr a comprehension of human anatomy for general knowledge (never hurts to know your own body!) and clinical; 2 Course description and objectives: Anatomy is at the core of all medical practice

  2. Minority Supplement to the NCI-Supported National Research Service Award Institutional Research Training Grants (T32S)

    Cancer.gov

    The National Cancer Institute (NCI) Center to Reduce Cancer Health Disparities (CRCHD) Diversity Training Branch (DTB) established a new strategy for increasing the number of underserved trainees engaged in basic, clinical, and population-based cancer research. This strategy is part of the NCI’s Continuing Umbrella of Research Experiences (CURE) Program. The CURE program begins with introductory science experiences at the high school student level and continues progressively and selectively to the production of well-trained scientists conducting independent cancer research.

  3. Anatomy and biomechanics of the craniovertebral junction.

    PubMed

    Lopez, Alejandro J; Scheer, Justin K; Leibl, Kayla E; Smith, Zachary A; Dlouhy, Brian J; Dahdaleh, Nader S

    2015-04-01

    The craniovertebral junction (CVJ) has unique anatomical structures that separate it from the subaxial cervical spine. In addition to housing vital neural and vascular structures, the majority of cranial flexion, extension, and axial rotation is accomplished at the CVJ. A complex combination of osseous and ligamentous supports allow for stability despite a large degree of motion. An understanding of anatomy and biomechanics is essential to effectively evaluate and address the various pathological processes that may affect this region. Therefore, the authors present an up-to-date narrative review of CVJ anatomy, normal and pathological biomechanics, and fixation techniques. PMID:25828496

  4. Anatomy of liver arteries for interventional radiology.

    PubMed

    Favelier, S; Germain, T; Genson, P-Y; Cercueil, J-P; Denys, A; Krausé, D; Guiu, B

    2015-06-01

    The availability of intra-arterial hepatic therapies (radio and/or chemo-embolisation, intra-arterial hepatic chemotherapy) has convinced radiologists to perfect their knowledge of the anatomy of the liver arteries. These sometimes, complex procedures most often require selective arterial catheterization. Knowledge of the different arteries in the liver and the peripheral organs is therefore essential to optimize the procedure and avoid eventual complications. This paper aims to describe the anatomy of the liver arteries and the variants, applying it to angiography images, and to understand the implications of such variations in interventional radiological procedures. PMID:24534562

  5. NCI Workshop Report: Clinical and Computational Requirements for Correlating Imaging Phenotypes with Genomics Signatures

    PubMed Central

    Colen, Rivka; Foster, Ian; Gatenby, Robert; Giger, Mary Ellen; Gillies, Robert; Gutman, David; Heller, Matthew; Jain, Rajan; Madabhushi, Anant; Madhavan, Subha; Napel, Sandy; Rao, Arvind; Saltz, Joel; Tatum, James; Verhaak, Roeland; Whitman, Gary

    2014-01-01

    The National Cancer Institute (NCI) Cancer Imaging Program organized two related workshops on June 26–27, 2013, entitled “Correlating Imaging Phenotypes with Genomics Signatures Research” and “Scalable Computational Resources as Required for Imaging-Genomics Decision Support Systems.” The first workshop focused on clinical and scientific requirements, exploring our knowledge of phenotypic characteristics of cancer biological properties to determine whether the field is sufficiently advanced to correlate with imaging phenotypes that underpin genomics and clinical outcomes, and exploring new scientific methods to extract phenotypic features from medical images and relate them to genomics analyses. The second workshop focused on computational methods that explore informatics and computational requirements to extract phenotypic features from medical images and relate them to genomics analyses and improve the accessibility and speed of dissemination of existing NIH resources. These workshops linked clinical and scientific requirements of currently known phenotypic and genotypic cancer biology characteristics with imaging phenotypes that underpin genomics and clinical outcomes. The group generated a set of recommendations to NCI leadership and the research community that encourage and support development of the emerging radiogenomics research field to address short-and longer-term goals in cancer research. PMID:25389451

  6. Gestalt theory and morbid anatomy.

    PubMed

    Doerr, W

    1984-01-01

    Contact with medical students as a university teacher has shown that there are different types of aptitude: 5/9 of German medical students possess a visual faculty, 3/9 are kinaesthetic and only about 1/9 have the gift of the auditive faculty. Apart from this, there is a general quality which may be termed gestalt perception or gestalt blindness. The fact that for decades the attempt was made to relate qualitative differences in the characteristics of medical observations and pathological and anatomical findings to quantitative changes was the reason for the development of the concept of Relationspathologie . Intellectual pre-occupation with the perception of "gestalt qualities" has resulted in pathology in general being seen as the expression of the biophysics of open systems and making an organismic evaluation of its phenomena. The aim of all natural science is the recognition of order. Theoretical biology seeks an order free from hypotheses. Theoretical pathology involves the application of gestalt philosophy to the detection and evaluation of all potentially dangerous disturbances. Theoretical pathology has nothing to do with "natural philosophy", the "natural history viewpoint", the " vitalism " of the turn of the century or the "holism" of the 1930s . Gestalt qualities can be characterized by means of the " Ehrenfels criteria". In most cases this means distinguishing between "space gestalt", "time gestalt", "tone gestalt", and "sentence gestalt". As defined by gestalt theory, mental and physical processes correspond. Gestalt can always be defined and understood in concrete terms. In the gestalt the conceptual contradiction between "external" and "internal" is overcome. External phenomena are the manifestations of internal nature. In the fields of pathological anatomy, gestalt theory has direct methodological relevance with regard to the following: a) the concept of homology b) the conceptual idea of what is known as "specific inflammation" c) the theory of stages in minor organ diseases d) the characterization of the various forms of pathomorphosis e) patho-anatomical diagnostics according to the laws of mathematical logic. The relationship between individual sciences and philosophy has always been critical. The individual science and philosophy are mutually obscured from one another. Research into facts and research into essence come together, as in a "gestalt circle", to form a single process of understanding. All lawfulness and order originates from a principle of the mind. The visible manifestation of this principle is the innermost nature of the gestalten . PMID:6426156

  7. Fostering Improved Anatomy and Physiology Instructor Pedagogy

    ERIC Educational Resources Information Center

    Mattheis, Allison; Jensen, Murray

    2014-01-01

    Despite widespread calls for reform in undergraduate science, technology, engineering, and mathematics education, effecting lasting change in instructor practice is challenging to achieve. This article describes the results of a 2-yr research study that involved efforts to develop the pedagogical expertise of a group of anatomy and physiology…

  8. Testing to Enhance Retention in Human Anatomy

    ERIC Educational Resources Information Center

    Logan, Jessica M.; Thompson, Andrew J.; Marshak, David W.

    2011-01-01

    Recent work in cognitive psychology has shown that repeatedly testing one's knowledge is a powerful learning aid and provides substantial benefits for retention of the material. To apply this in a human anatomy course for medical students, 39 fill-in-the-blank quizzes of about 50 questions each, one for each region of the body, and four about the…

  9. Cardiac Anatomy and Physiology: A Review

    Microsoft Academic Search

    Mary Gavaghan

    1998-01-01

    This article reviews the normal anatomy and physiology of the heart. Understanding the normal anatomic and physiologic relationships described in this article will help perioperative nurses care for patients who are undergoing cardiac procedures. Such knowledge also assists nurses in educating patients about cardiac procedures and about activities that can prevent, reverse, or improve cardiac illness. AORN J 67 (April

  10. Proximal femoral anatomy of omomyiform primates

    Microsoft Academic Search

    Peter Schmid

    1996-01-01

    Compared to the adapid primates, the limb skeleton of omomyiforms is only poorly represented. With the discovery of some new material, the proximal femur is now known in several taxa, including representatives from both of the recognized families. We describe the femur of a very small North American omomyid from the Bridger formation (middle Eocene) and compare its anatomy with

  11. Real-Time Photorealistic Virtual Human Anatomy

    Microsoft Academic Search

    Yanling Liu; Jim X. Chen; Lin Yang

    2008-01-01

    The authors' voxel-based surface-reconstruction algorithm provides fast surface reconstruction and real-time modification to volume data. Focusing on high-quality human parts rendering as well as real-time interaction, the system provides a better platform for virtually learning human anatomy.

  12. Odynophagia Secondary to Variant Thyroid Cartilage Anatomy

    Microsoft Academic Search

    Doris Lin; Nancy Fischbein; David W. Eisele

    2005-01-01

    We present a case of a displaced superior cornu of the thyroid cartilage causing odynophagia and a foreign body sensation of the pharynx. Diagnosis was made by computed tomography (CT) scan and confirmed by direct endoscopic examination. We review the literature that addresses possible etiologies of this variant anatomy and review treatment options.

  13. Anatomy and physiology of genital organs - women.

    PubMed

    Graziottin, Alessandra; Gambini, Dania

    2015-01-01

    "Anatomy is destiny": Sigmund Freud viewed human anatomy as a necessary, although not a sufficient, condition for understanding the complexity of human sexual function with a solid biologic basis. The aim of the chapter is to describe women's genital anatomy and physiology, focusing on women's sexual function with a clinically oriented vision. Key points include: embryology, stressing that the "female" is the anatomic "default" program, differentiated into "male" only in the presence of androgens at physiologic levels for the gestational age; sex determination and sex differentiation, describing the interplay between anatomic and endocrine factors; the "clitoral-urethral-vaginal" complex, the most recent anatomy reading of the corpora cavernosa pattern in women; the controversial G spot; the role of the pelvic floor muscles in modulating vaginal receptivity and intercourse feelings, with hyperactivity leading to introital dyspareunia and contributing to provoked vestibulodynia and recurrent postcoital cystitis, whilst lesions during delivery reduce vaginal sensations, genital arousability, and orgasm; innervation, vessels, bones, ligaments; and the physiology of women's sexual response. Attention to physiologic aging focuses on "low-grade inflammation," genital and systemic, with its impact on women sexual function, especially after the menopause, if the woman does not or cannot use hormone replacement therapy. PMID:26003238

  14. Computerized grading of anatomy laboratory practical examinations.

    PubMed

    Krippendorf, Beth B; Bolender, David L; Kolesari, Gary L

    2008-01-01

    At the Medical College of Wisconsin, a procedure was developed to allow computerized grading and grade reporting of laboratory practical examinations in the Clinical Human Anatomy course. At the start of the course, first year medical students were given four Lists of Structures. On these lists, numbered items were arranged alphabetically; the items were anatomical structures that could be tagged on a given lab practical examination. Each lab exam featured an anatomy laboratory component and a computer laboratory component. For the anatomy lab component, students moved from one question station to another at timed intervals and identified tagged anatomical structures. As students identified a tagged structure, they referred to a copy of the list (provided with their answer sheet) and wrote the number corresponding to the structure on their answer sheet. Immediately after the anatomy lab component, students were escorted to a computer instruction laboratory where they typed their answer numbers into a secured testing component of a learning management system that recorded their answers for automatic grading. After a brief review of examination scores and item analysis by faculty, exam scores were reported to students electronically. Adding this brief computer component to each lab exam greatly reduced faculty grading time, reduced grading errors and provided faster performance feedback for students without changing overall student performance. PMID:19177415

  15. Anatomy and Physiology. Revised Teacher Edition.

    ERIC Educational Resources Information Center

    Hartman, Danene; And Others

    This curriculum guide contains 14 units of instruction for a course in anatomy and physiology for surgical technology students. The units cover the following topics: (1) organization of the body; (2) cells, tissues, and membranes; (3) integumentary system; (4) skeletal system; (5) muscular system; (6) nervous system; (7) special sense organs; (8)…

  16. Internal Anatomy of the Arthropods I

    E-print Network

    Brown, Christopher A.

    information to the mouthparts #12;4 Endocrine System FUNCTION: Communication within the organism; external communication Endocrine system works via release of chemicals called hormones from specialized cells or glands1 Internal Anatomy of the Arthropods I Muscular System FUNCTION: to move body parts Insects possess

  17. A Syllabus for Biol 242--Human Anatomy.

    ERIC Educational Resources Information Center

    Jacob, Willis H.

    This document is the fall and spring semester course syllabus of Biology 242--Human Anatomy at Southern University (Louisiana). Sections include: (1) Descriptive Information; (2) Specification of Course Goals and Objectives; (3) Readings; (4) Description of Instructional Procedures; (5) Course Requirements; (6) Course Schedule; (7) Evaluation of…

  18. Project

    Microsoft Academic Search

    E. Petersen; J. Ali-Adeeb; T. Cerling; M. Chan; D. Chapman; L. Cohen; M. Davis; D. Chapmandearing; S. Hill; S. Hynek; L. Millward; S. O'Grady; L. Richards; K. Solomon; S. Sampson; J. Schafer; L. Zanno; E. Zipser

    2004-01-01

    Project WEST (Water, the Environment, Science, and Teaching) is a graduate student fellowship program funded by a GK-12 grant from the National Science Foundation. WEST links the University of Utah, the Utah Museum of Natural History, and the Salt Lake City school district in enhancing inquiry based science teaching in grades 4, 8, and 9 and the interdisciplinary training of

  19. Gross anatomy and ultrasonographic images of the reproductive system of the Malayan tapir (Tapirus indicus).

    PubMed

    Lilia, K; Rosnina, Y; Abd Wahid, H; Zahari, Z Z; Abraham, M

    2010-12-01

    The Malayan tapir (Tapirus indicus) is the largest among the four tapir species and is listed as an endangered species. Ultrasound examination and description of the external anatomy of the female reproductive system of three adult females were performed, whereas the internal anatomy was investigated in necropsied samples of four adult females and one subadult female. Descriptions of the male external genitalia were conducted on one adult male. Gross examination revealed the presence of a bicornuate uterus. The uterine cervix is firm and muscular with projections towards its lumen, which is also evident on ultrasonography. The elongated and relatively small ovaries, which have a smooth surface, could not be imaged on ultrasonography, due to their anatomical position. The testes are located inside a slightly pendulous scrotum that is sparsely covered with soft, short hairs. The penis has one dorsal and two lateral penile projections just proximal to the glans penis. PMID:20809915

  20. News Note: New NCI Program Will Help Aid Development and Validation of Tests Used in Cancer Clinical Trials

    Cancer.gov

    In order to conduct rigorous and robust clinical trials, the tests, or assays, used in those trials must meet optimum standards. To bring those assays and standards in line with 21st century technology, NCI's Division of Cancer Treatment and Diagnosis has started a new program called the Clinical Assay Development Program (CADP) to facilitate development and validation of clinical assays.

  1. Letter from the National Cancer Institute to the Scientific Community To the NCI-supported scientific community

    E-print Network

    McQuade, D. Tyler

    Letter from the National Cancer Institute to the Scientific Community To the NCI- and intramural programs, including non-competitive (type 5) grant renewals, cancer centers, and research contracts. In addition, we do not expect to reduce salaries, place employees on furlough, or take other

  2. NCI's High Performance Computing (HPC) and High Performance Data (HPD) Computing Platform for Environmental and Earth System Data Science

    NASA Astrophysics Data System (ADS)

    Evans, Ben; Allen, Chris; Antony, Joseph; Bastrakova, Irina; Gohar, Kashif; Porter, David; Pugh, Tim; Santana, Fabiana; Smillie, Jon; Trenham, Claire; Wang, Jingbo; Wyborn, Lesley

    2015-04-01

    The National Computational Infrastructure (NCI) has established a powerful and flexible in-situ petascale computational environment to enable both high performance computing and Data-intensive Science across a wide spectrum of national environmental and earth science data collections - in particular climate, observational data and geoscientific assets. This paper examines 1) the computational environments that supports the modelling and data processing pipelines, 2) the analysis environments and methods to support data analysis, and 3) the progress so far to harmonise the underlying data collections for future interdisciplinary research across these large volume data collections. NCI has established 10+ PBytes of major national and international data collections from both the government and research sectors based on six themes: 1) weather, climate, and earth system science model simulations, 2) marine and earth observations, 3) geosciences, 4) terrestrial ecosystems, 5) water and hydrology, and 6) astronomy, social and biosciences. Collectively they span the lithosphere, crust, biosphere, hydrosphere, troposphere, and stratosphere. The data is largely sourced from NCI's partners (which include the custodians of many of the major Australian national-scale scientific collections), leading research communities, and collaborating overseas organisations. New infrastructures created at NCI mean the data collections are now accessible within an integrated High Performance Computing and Data (HPC-HPD) environment - a 1.2 PFlop supercomputer (Raijin), a HPC class 3000 core OpenStack cloud system and several highly connected large-scale high-bandwidth Lustre filesystems. The hardware was designed at inception to ensure that it would allow the layered software environment to flexibly accommodate the advancement of future data science. New approaches to software technology and data models have also had to be developed to enable access to these large and exponentially increasing data volumes at NCI. Traditional HPC and data environments are still made available in a way that flexibly provides the tools, services and supporting software systems on these new petascale infrastructures. But to enable the research to take place at this scale, the data, metadata and software now need to evolve together - creating a new integrated high performance infrastructure. The new infrastructure at NCI currently supports a catalogue of integrated, reusable software and workflows from earth system and ecosystem modelling, weather research, satellite and other observed data processing and analysis. One of the challenges for NCI has been to support existing techniques and methods, while carefully preparing the underlying infrastructure for the transition needed for the next class of Data-intensive Science. In doing so, a flexible range of techniques and software can be made available for application across the corpus of data collections available, and to provide a new infrastructure for future interdisciplinary research.

  3. New NCI-N87-derived human gastric epithelial line after human telomerase catalytic subunit over-expression

    PubMed Central

    Saraiva-Pava, Kathy; Navabi, Nazanin; Skoog, Emma C; Lindén, Sara K; Oleastro, Mónica; Roxo-Rosa, Mónica

    2015-01-01

    AIM: To establish a cellular model correctly mimicking the gastric epithelium to overcome the limitation in the study of Helicobacter pylori (H. pylori) infection. METHODS: Aiming to overcome this limitation, clones of the heterogenic cancer-derived NCI-N87 cell line were isolated, by stably-transducing it with the human telomerase reverse-transcriptase (hTERT) catalytic subunit gene. The clones were first characterized regarding their cell growth pattern and phenotype. For that we measured the clones’ adherence properties, expression of cell-cell junctions’ markers (ZO-1 and E-cadherin) and ability to generate a sustained transepithelial electrical resistance. The gastric properties of the clones, concerning expression of mucins, zymogens and glycan contents, were then evaluated by haematoxylin and eosin staining, Periodic acid Schiff (PAS) and PAS/Alcian Blue-staining, immunocytochemistry and Western blot. In addition, we assessed the usefulness of the hTERT-expressing gastric cell line for H. pylori research, by performing co-culture assays and measuring the IL-8 secretion, by ELISA, upon infection with two H. pylori strains differing in virulence. RESULTS: Compared with the parental cell line, the most promising NCI-hTERT-derived clones (CL5 and CL6) were composed of cells with homogenous phenotype, presented higher relative telomerase activities, better adhesion properties, ability to be maintained in culture for longer periods after confluency, and were more efficient in PAS-reactive mucins secretion. Both clones were shown to produce high amounts of MUC1, MUC2 and MUC13. NCI-hTERT-CL5 mucins were shown to be decorated with blood group H type 2 (BG-H), Lewis-x (Lex), Ley and Lea and, in a less extent, with BG-A antigens, but the former two antigens were not detected in the NCI-hTERT-CL6. None of the clones exhibited detectable levels of MUC6 nor sialylated Lex and Lea glycans. Entailing good gastric properties, both NCI-hTERT-clones were found to produce pepsinogen-5 and human gastric lipase. The progenitor-like phenotype of NCI-hTERT-CL6 cells was highlighted by large nuclei and by the apical vesicular-like distribution of mucin 5AC and Pg5, supporting the accumulation of mucus-secreting and zymogens-chief mature cells functions. CONCLUSION: These traits, in addition to resistance to microaerobic conditions and good responsiveness to H. pylori co-culture, in a strain virulence-dependent manner, make the NCI-hTERT-CL6 a promising model for future in vitro studies.

  4. Direct cortical hemodynamic mapping of somatotopy of pig nostril sensation by functional near-infrared cortical imaging (fNCI).

    PubMed

    Uga, Minako; Saito, Toshiyuki; Sano, Toshifumi; Yokota, Hidenori; Oguro, Keiji; Rizki, Edmi Edison; Mizutani, Tsutomu; Katura, Takusige; Dan, Ippeita; Watanabe, Eiju

    2014-05-01

    Functional near-infrared spectroscopy (fNIRS) is a neuroimaging technique for the noninvasive monitoring of human brain activation states utilizing the coupling between neural activity and regional cerebral hemodynamics. Illuminators and detectors, together constituting optodes, are placed on the scalp, but due to the presence of head tissues, an inter-optode distance of more than 2.5cm is necessary to detect cortical signals. Although direct cortical monitoring with fNIRS has been pursued, a high-resolution visualization of hemodynamic changes associated with sensory, motor and cognitive neural responses directly from the cortical surface has yet to be realized. To acquire robust information on the hemodynamics of the cortex, devoid of signal complications in transcranial measurement, we devised a functional near-infrared cortical imaging (fNCI) technique. Here we demonstrate the first direct functional measurement of temporal and spatial patterns of cortical hemodynamics using the fNCI technique. For fNCI, inter-optode distance was set at 5mm, and light leakage from illuminators was prevented by a special optode holder made of a light-shielding rubber sheet. fNCI successfully detected the somatotopy of pig nostril sensation, as assessed in comparison with concurrent and sequential somatosensory-evoked potential (SEP) measurements on the same stimulation sites. Accordingly, the fNCI system realized a direct cortical hemodynamic measurement with a spatial resolution comparable to that of SEP mapping on the rostral region of the pig brain. This study provides an important initial step toward realizing functional cortical hemodynamic monitoring during neurosurgery of human brains. PMID:24418508

  5. NCI's national environmental research data collection: metadata management built on standards and preparing for the semantic web

    NASA Astrophysics Data System (ADS)

    Wang, Jingbo; Bastrakova, Irina; Evans, Ben; Gohar, Kashif; Santana, Fabiana; Wyborn, Lesley

    2015-04-01

    National Computational Infrastructure (NCI) manages national environmental research data collections (10+ PB) as part of its specialized high performance data node of the Research Data Storage Infrastructure (RDSI) program. We manage 40+ data collections using NCI's Data Management Plan (DMP), which is compatible with the ISO 19100 metadata standards. We utilize ISO standards to make sure our metadata is transferable and interoperable for sharing and harvesting. The DMP is used along with metadata from the data itself, to create a hierarchy of data collection, dataset and time series catalogues that is then exposed through GeoNetwork for standard discoverability. This hierarchy catalogues are linked using a parent-child relationship. The hierarchical infrastructure of our GeoNetwork catalogues system aims to address both discoverability and in-house administrative use-cases. At NCI, we are currently improving the metadata interoperability in our catalogue by linking with standardized community vocabulary services. These emerging vocabulary services are being established to help harmonise data from different national and international scientific communities. One such vocabulary service is currently being established by the Australian National Data Services (ANDS). Data citation is another important aspect of the NCI data infrastructure, which allows tracking of data usage and infrastructure investment, encourage data sharing, and increasing trust in research that is reliant on these data collections. We incorporate the standard vocabularies into the data citation metadata so that the data citation become machine readable and semantically friendly for web-search purpose as well. By standardizing our metadata structure across our entire data corpus, we are laying the foundation to enable the application of appropriate semantic mechanisms to enhance discovery and analysis of NCI's national environmental research data information. We expect that this will further increase the data discoverability and encourage the data sharing and reuse within the community, increasing the value of the data much further than its current use.

  6. Radiographic protocol and normal anatomy of the hind feet in the white rhinoceros (Ceratotherium simum).

    PubMed

    Dudley, Robert J; Wood, Simon P; Hutchinson, John R; Weller, Renate

    2015-01-01

    Foot pathology is a common and important health concern in captive rhinoceroses worldwide, but osteopathologies are rarely diagnosed, partly because of a lack of radiographic protocols. Here, we aimed to develop the first radiographic protocol for rhinoceros feet and describe the radiographic anatomy of the white rhinoceros (Ceratotherium simum) hind foot (pes). Computed tomographic images were obtained of nine cadaver pedes from seven different white rhinoceroses and assessed for pathology. A single foot deemed free of pathology was radiographed using a range of different projections and exposures to determine the best protocol. 3D models were produced from the CT images and were displayed with the real radiographs to describe the normal radiographic anatomy of the white rhinoceros pes. An optimal radiographic projection was determined for each bone in the rhinoceros pes focusing on highlighting areas where pathology has been previously described. The projections deemed to be most useful were D60Pr-PlDiO (digit III), D45Pr45M-PlDiLO (digit II), and D40Pr35L-PlDiLO (digit IV). The primary beam was centered 5-7 cm proximal to the cuticle on the digit of interest. Articular surfaces, ridges, grooves, tubercles, processes and fossae were identified. The radiographic protocol we have developed along with the normal radiographic anatomy we have described will allow for more accessible and effective diagnosis of white rhinoceros foot osteopathologies. PMID:25339254

  7. Cloning and sequencing of the levansucrase gene from Acetobacter xylinum NCI 1005.

    PubMed

    Tajima, K; Tanio, T; Kobayashi, Y; Kohno, H; Fujiwara, M; Shiba, T; Erata, T; Munekata, M; Takai, M

    2000-08-31

    The levansucrase gene (lsxA) was cloned from the genomic DNA of Acetobacter xylinum NCI 1005, and the nucleotide sequence of the lsxA gene (1,293 bp) was determined. The deduced amino acid sequence of the lsxA gene showed 57.4% and 46.2% identity with the levansucrases from Zymomonas mobilis and Erwinia amylovora, respectively, while only 35.2% identity with that from Acetobacter diazotrophicus. The gene product of lsxA (LsxA) that was overproduced in E. coli coded for a polypeptide of molecular mass 47 kDa. The LsxA released glucose and produced polysaccharide from sucrose, the structure of which was analyzed by nuclear magnetic resonance spectroscopy and determined to be a beta-(2,6)-linked polyfructan. PMID:10997873

  8. NIOSH/NCI study of exposure to diesel exhaust in underground mines -- An industry perspective

    SciTech Connect

    Pritchard, C.J.

    1999-07-01

    In 1992, the National Institute for Occupational Safety and Health (NIOSH) initiated a study, funded by the National Cancer Institute (NCI), to evaluate the health effects, if any, involving underground miners exposure to diesel exhaust. An industry organization, the Methane Awareness Research Group (MARG) already in place to respond to gassy mine related issues, was redirected to work with diesel concerns. In 1995, NIOSH released a draft protocol and feasibility assessment, indicating its intent to initiate a study at 14 underground mines, some of which were operated by MARG members. After considerable debate on the study protocol, in-mine industrial hygiene studies were begun in December, 1997 and expected to end in early 1999.

  9. Moving the mountain: analysis of the effort required to transform comparative anatomy into computable anatomy

    PubMed Central

    Dahdul, Wasila; Dececchi, T. Alexander; Ibrahim, Nizar; Lapp, Hilmar; Mabee, Paula

    2015-01-01

    The diverse phenotypes of living organisms have been described for centuries, and though they may be digitized, they are not readily available in a computable form. Using over 100 morphological studies, the Phenoscape project has demonstrated that by annotating characters with community ontology terms, links between novel species anatomy and the genes that may underlie them can be made. But given the enormity of the legacy literature, how can this largely unexploited wealth of descriptive data be rendered amenable to large-scale computation? To identify the bottlenecks, we quantified the time involved in the major aspects of phenotype curation as we annotated characters from the vertebrate phylogenetic systematics literature. This involves attaching fully computable logical expressions consisting of ontology terms to the descriptions in character-by-taxon matrices. The workflow consists of: (i) data preparation, (ii) phenotype annotation, (iii) ontology development and (iv) curation team discussions and software development feedback. Our results showed that the completion of this work required two person-years by a team of two post-docs, a lead data curator, and students. Manual data preparation required close to 13% of the effort. This part in particular could be reduced substantially with better community data practices, such as depositing fully populated matrices in public repositories. Phenotype annotation required ?40% of the effort. We are working to make this more efficient with Natural Language Processing tools. Ontology development (40%), however, remains a highly manual task requiring domain (anatomical) expertise and use of specialized software. The large overhead required for data preparation and ontology development contributed to a low annotation rate of approximately two characters per hour, compared with 14 characters per hour when activity was restricted to character annotation. Unlocking the potential of the vast stores of morphological descriptions requires better tools for efficiently processing natural language, and better community practices towards a born-digital morphology. Database URL: http://kb.phenoscape.org PMID:25972520

  10. An Approach to the Anatomical Correlation of Species through the Foundational Model of Anatomy

    E-print Network

    Washington at Seattle, University of

    and relationships for correlating human anatomy, at all levels of structural organization, with the anatomy of any, and then propose an approach to mapping, as a prototype, instances of mouse anatomy to human anatomy. Before- relations are to be made. Although the FMA has been developed and instanti- ated for human anatomy, its

  11. REVISED Syllabus Human Anatomy -Biol 253 Fall 2013 page 1 of 8

    E-print Network

    Houde, Peter

    REVISED Syllabus Human Anatomy - Biol 253 Fall 2013 page 1 of 8 REVISED Welcome to Human Anatomy choose. #12;REVISED Syllabus Human Anatomy - Biol 253 Fall 2013 page 2 of 8 Professor: Peter Houde, Ph relating to classes. Corequisites: Biol 253 Human Anatomy and Biol 253L Human Anatomy Laboratory

  12. Complementing anatomy education using three-dimensional anatomy mobile software applications on tablet computers.

    PubMed

    Lewis, T L; Burnett, B; Tunstall, R G; Abrahams, P H

    2014-04-01

    Anatomy has traditionally been a cornerstone of medical education, which has been taught via dissection and didactic lectures. The rising prevalence of mobile tablet technology means medical software applications ("apps") play an increasingly important role in medical education. The applications highlighted in this article will aid anatomical educators to identify which are the most useful in clinical, academic, and educational environments. These have been systematically identified by downloading all applications with keywords related to anatomy and then carrying out qualitative assessment. Novel anatomy applications from developers such as Visible Body, 3D4Medical, and Pocket Anatomy allow students to visualize and manipulate complex anatomical structures using detailed 3D models. They often contain additional content including clinical correlations and a range of media from instructional videos to interactive quiz functions. The strength of tablet technology lies in its ability to consolidate and present anatomical information to the user in the most appropriate manner for their learning style. The only question mark remains over the level of detail and accuracy of these applications. Innovative medical educators who embrace tablet technology will find that anatomy applications serve as a useful learning tool when used in conjunction with existing teaching setups. PMID:23661327

  13. Fostering improved anatomy and physiology instructor pedagogy.

    PubMed

    Mattheis, Allison; Jensen, Murray

    2014-12-01

    Despite widespread calls for reform in undergraduate science, technology, engineering, and mathematics education, effecting lasting change in instructor practice is challenging to achieve. This article describes the results of a 2-yr research study that involved efforts to develop the pedagogical expertise of a group of anatomy and physiology instructors at the college level. Data were collected through a series of individual interviews that included the use of the Teacher Beliefs Inventory questionnaire (23) along with observations onsite in participants' college classrooms and at process-oriented guided inquiry learning (POGIL) curriculum writing workshops. Findings indicated attitudinal shifts on the part of participants from teacher-centered to more student-centered pedagogy and supported the benefits of long-term professional development for instructors. Here, we documented the successful progress of these professors as they participated in a curriculum development process that emphasized student-centered teaching with the goal of promoting broader change efforts in introductory anatomy and physiology. PMID:25434015

  14. The emerging discipline of Computational Functional Anatomy

    PubMed Central

    Miller, Michael I.; Qiu, Anqi

    2010-01-01

    Computational Functional Anatomy (CFA) is the study of functional and physiological response variables in anatomical coordinates. For this we focus on two things: (i) the construction of bijections (via diffeomorphisms) between the coordinatized manifolds of human anatomy, and (ii) the transfer (group action and parallel transport) of functional information into anatomical atlases via these bijections. We review advances in the unification of the bijective comparison of anatomical submanifolds via point-sets including points, curves and surface triangulations as well as dense imagery. We examine the transfer via these bijections of functional response variables into anatomical coordinates via group action on scalars and matrices in DTI as well as parallel transport of metric information across multiple templates which preserves the inner product. PMID:19103297

  15. Endoscopic anatomy of the pediatric middle ear.

    PubMed

    Isaacson, Glenn

    2014-01-01

    Traditionally, otologists have aimed to produce a clean, dry, safe ear with the best possible hearing result. More recently, "less invasively" has been added to this list of goals. The development of small-diameter, high-quality rigid endoscopes and high-definition video systems has made totally endoscopic, transcanal surgery a reality in adult otology and a possibility in pediatric otology. This article reviews the anatomy of the pediatric middle ear and its surrounding airspaces and structures based on the work of dozens of researchers over the past 50 years. It will focus on the developmental changes in ear anatomy from birth through the first decade, when structure and function change most rapidly. Understanding the limits and possibilities afforded by new endoscopic technologies, the pediatric otologist can strive for results matching or exceeding those achieved by more invasive surgical approaches. PMID:24154745

  16. Root anatomy of grasses and clovers

    Microsoft Academic Search

    Kathleen Soper

    1959-01-01

    Comparisons are made of the anatomy of the mature parts of roots of the grasses Lolium perenne, Dactylis glomerata, Glyceria fluitans, and Alopecurus pratensis.Noteworthy features include a well-marked exodermis and a subjacent layer of sclerenchyma in Glyceria; the greater lignification of the Dactylis root as compared with Lolium; the greater total cross-sectional area of metaxylem vessels in Dactylis compared with

  17. A gross anatomy ontology for hymenoptera.

    PubMed

    Yoder, Matthew J; Mikó, István; Seltmann, Katja C; Bertone, Matthew A; Deans, Andrew R

    2010-01-01

    Hymenoptera is an extraordinarily diverse lineage, both in terms of species numbers and morphotypes, that includes sawflies, bees, wasps, and ants. These organisms serve critical roles as herbivores, predators, parasitoids, and pollinators, with several species functioning as models for agricultural, behavioral, and genomic research. The collective anatomical knowledge of these insects, however, has been described or referred to by labels derived from numerous, partially overlapping lexicons. The resulting corpus of information--millions of statements about hymenopteran phenotypes--remains inaccessible due to language discrepancies. The Hymenoptera Anatomy Ontology (HAO) was developed to surmount this challenge and to aid future communication related to hymenopteran anatomy. The HAO was built using newly developed interfaces within mx, a Web-based, open source software package, that enables collaborators to simultaneously contribute to an ontology. Over twenty people contributed to the development of this ontology by adding terms, genus differentia, references, images, relationships, and annotations. The database interface returns an Open Biomedical Ontology (OBO) formatted version of the ontology and includes mechanisms for extracting candidate data and for publishing a searchable ontology to the Web. The application tools are subject-agnostic and may be used by others initiating and developing ontologies. The present core HAO data constitute 2,111 concepts, 6,977 terms (labels for concepts), 3,152 relations, 4,361 sensus (links between terms, concepts, and references) and over 6,000 text and graphical annotations. The HAO is rooted with the Common Anatomy Reference Ontology (CARO), in order to facilitate interoperability with and future alignment to other anatomy ontologies, and is available through the OBO Foundry ontology repository and BioPortal. The HAO provides a foundation through which connections between genomic, evolutionary developmental biology, phylogenetic, taxonomic, and morphological research can be actualized. Inherent mechanisms for feedback and content delivery demonstrate the effectiveness of remote, collaborative ontology development and facilitate future refinement of the HAO. PMID:21209921

  18. The Foundational Model of Anatomy Ontology

    Microsoft Academic Search

    Cornelius Rosse; José L. V. Mejino Jr

    Anatomy is the structure of biological organisms. The term also denotes the scientific discipline devoted to the study of\\u000a anatomical entities and the structural and developmental relations that obtain among these entities during the lifespan of\\u000a an organism. Anatomical entities are the independent continuants of biomedical reality on which physiological and disease\\u000a processes depend, and which, in response to etiological

  19. Anatomy and Physiology of Anorectal Prolapse

    Microsoft Academic Search

    S. R. Brown; A. J. Shorthouse

    \\u000a The pathophysiology of hemorrhoids and obstructed defecation requires a sound knowledge of the structure and function of the\\u000a pelvic floor. The essential structure of this area is disussed with a specific emphasis on applied anatomy. Current theories\\u000a regarding the physiology of continence and defecation are described. These concepts are then applied to explain the underlying\\u000a pathophysiology of hemorrhoids and obstructed

  20. Arthroscopy in cattle: technique and normal anatomy.

    PubMed

    Lardé, Hélène; Nichols, Sylvain

    2014-03-01

    Arthroscopy has all the advantages of minimally invasive surgery in cattle. Specialized equipment and knowledge of normal joint anatomy of cattle are mandatory for successful arthroscopy. The surgical technique is different in cattle compared with the horse. Thick skin and joint capsules complicate movement of the arthroscope within the joints. In cattle, septic arthritis and osteochondrosis are the most frequent disorders suitable for arthroscopic treatment. PMID:24534667

  1. A Gross Anatomy Ontology for Hymenoptera

    PubMed Central

    Yoder, Matthew J.; Mikó, István; Seltmann, Katja C.; Bertone, Matthew A.; Deans, Andrew R.

    2010-01-01

    Hymenoptera is an extraordinarily diverse lineage, both in terms of species numbers and morphotypes, that includes sawflies, bees, wasps, and ants. These organisms serve critical roles as herbivores, predators, parasitoids, and pollinators, with several species functioning as models for agricultural, behavioral, and genomic research. The collective anatomical knowledge of these insects, however, has been described or referred to by labels derived from numerous, partially overlapping lexicons. The resulting corpus of information—millions of statements about hymenopteran phenotypes—remains inaccessible due to language discrepancies. The Hymenoptera Anatomy Ontology (HAO) was developed to surmount this challenge and to aid future communication related to hymenopteran anatomy. The HAO was built using newly developed interfaces within mx, a Web-based, open source software package, that enables collaborators to simultaneously contribute to an ontology. Over twenty people contributed to the development of this ontology by adding terms, genus differentia, references, images, relationships, and annotations. The database interface returns an Open Biomedical Ontology (OBO) formatted version of the ontology and includes mechanisms for extracting candidate data and for publishing a searchable ontology to the Web. The application tools are subject-agnostic and may be used by others initiating and developing ontologies. The present core HAO data constitute 2,111 concepts, 6,977 terms (labels for concepts), 3,152 relations, 4,361 sensus (links between terms, concepts, and references) and over 6,000 text and graphical annotations. The HAO is rooted with the Common Anatomy Reference Ontology (CARO), in order to facilitate interoperability with and future alignment to other anatomy ontologies, and is available through the OBO Foundry ontology repository and BioPortal. The HAO provides a foundation through which connections between genomic, evolutionary developmental biology, phylogenetic, taxonomic, and morphological research can be actualized. Inherent mechanisms for feedback and content delivery demonstrate the effectiveness of remote, collaborative ontology development and facilitate future refinement of the HAO. PMID:21209921

  2. Exercises in anatomy: the normal heart.

    PubMed

    Anderson, Robert H; Sarwark, Anne; Spicer, Diane E; Backer, Carl L

    2014-01-01

    In the first of our exercises in anatomy, created for the Multimedia Manual of the European Association of Cardiothoracic Surgery, we emphasized that thorough knowledge of intracardiac anatomy was an essential part of the training for all budding cardiac surgeons, explaining how we had used the archive of congenitally malformed hearts maintained at Lurie Children's Hospital in Chicago to prepare a series of videoclips, demonstrating the salient features of tetralogy of Fallot. In this series of videoclips, we extend our analysis of the normal heart, since for our initial exercise we had concentrated exclusively on the structure of the right ventricular outflow tract. We begin our overview of normal anatomy by emphasizing the need, in the current era, to describe the heart in attitudinally appropriate fashion. Increasingly, clinicians are demonstrating the features of the heart as it is located within the body. It is no longer satisfactory, therefore, to describe these components in a 'Valentine' fashion, as continues to be the case in most textbooks of normal or cardiac anatomy. We then emphasize the importance of the so-called morphological method, which states that structures within the heart should be defined on the basis of their own intrinsic morphology, and not according to other parts, which are themselves variable. We continue by using this concept to show how it is the appendages that serve to distinguish between the atrial chambers, while the apical trabecular components provide the features to distinguish the ventricles. We then return to the cardiac chambers, emphasizing features of surgical significance, in particular the locations of the cardiac conduction tissues. We proceed by examining the cardiac valves, and conclude by providing a detailed analysis of the septal structures. PMID:25500767

  3. Microsurgical anatomy of the ocular motor nerves

    Microsoft Academic Search

    Yi ZhangHao; Hao Liu; En-Zhong Liu; You-Zhi Lin; Shi-Guang Zhao; Guo-Hua Jing

    2010-01-01

    This study was designed to provide anatomic data to help surgeons avoid damage to the ocular motor nerves during intraorbital\\u000a operations. The microsurgical anatomy of the ocular motor nerves was studied in 50 adult cadaveric heads (100 orbits). Dissections\\u000a were performed with a microscope. The nerves were exposed and the neural and muscular relationships of each portion of the\\u000a nerve

  4. Testing to enhance retention in human anatomy.

    PubMed

    Logan, Jessica M; Thompson, Andrew J; Marshak, David W

    2011-01-01

    Recent work in cognitive psychology has shown that repeatedly testing one's knowledge is a powerful learning aid and provides substantial benefits for retention of the material. To apply this in a human anatomy course for medical students, 39 fill-in-the-blank quizzes of about 50 questions each, one for each region of the body, and four about the nervous system, were developed. The quizzes were optional, and no credit was awarded. They were posted online using Blackboard, which provided feedback, and they were very popular. To determine whether the quizzes had any effect on retention, they were given in a controlled setting to 21 future medical and dental students. The weekly quizzes included questions on regional anatomy and an expanded set of questions on the nervous system. Each question about the nervous system was given three times, in a slightly different form each time. The second quiz was given approximately half an hour after the first one, and the third was given one week after the second to assess retention. The quizzes were unpopular, but students showed robust improvement on the questions about the nervous system. The scores increased by almost 9% on the second quiz, with no intervention except viewing the correct answers. The scores were 29% higher on the third quiz than on the first, and there was also a positive correlation between the grades on the quizzes and the final examination. Thus, repeated testing is an effective strategy for learning and retaining information about human anatomy. PMID:21805688

  5. Anatomy of a Smart house

    SciTech Connect

    Kennedy, L.

    1988-07-01

    The author describes the Gas Laboratory House in Bowie, MD. It is being built as a SMART HOUSE. This means it will contain a whole-house control system made up of communication chips, computer programs and microprocessor-based controllers. A single cable carries signals from the chips to many different types of appliances. Flexible gas piping forms a ''circulatory system'' that makes the house completely compatible with natural gas appliances. The SMART HOUSE is fully programmable so that appliances can be told when to turn on and off. It can also have a zoned space-conditioning system, allowing sections of the house to be heated or cooled independently. The authors explains how the system works and the project's development schedule.

  6. Wahlfach I: Ansthesiologie und Intensivmedizin, Anatomie Modul-Code: WP 247

    E-print Network

    Manstein, Dietmar J.

    Wahlfach I: Anästhesiologie und Intensivmedizin, Anatomie Modul-Code: WP 247 Wahlpflichtveranstaltung mit mind. 10 bis max. 15 Teilnehmern Thema: Anatomy Meets Anesthesia Lehrverantwortlicher: Dr. Jan Anatomie Veranstaltungsort: Seminarraum Klinik für Anästhesiologie und Intensivmedizin (Geb. K5, Knoten D

  7. Computational framework for generating transport models from databases of microvascular anatomy.

    PubMed

    Beard, D A

    2001-10-01

    Quantitative descriptions of transport and exchange in physiological systems should make use of the emerging wealth of data on vascular anatomic structure. These descriptions may take the form of computational models which then must be incorporated into the comprehensive database of knowledge of microcirculatory physiology being developed under the title, The Microcirculation Physiome Project. Toward this end we present a simple and efficient computational method for simulating transport (advection, permeation, diffusion) in tissues containing microvascular structures of arbitrary complexity. The method is convenient because transport is simulated on a regular Cartesian lattice, and efficient because features of the anatomy are resolved within individual volume elements of the lattice. As a result, relatively low-resolution lattices yield accurate results. Therefore the method provides a feasible approach for studying a general class of transport problems in the context of realistic representations of vascular anatomy. PMID:11764314

  8. NCI Launches New Initiative to Identify Genetic Risk Factors for Breast and Prostate Cancer | Office of Cancer Genomics

    Cancer.gov

    The National Cancer Institute (NCI), part of the National Institutes of Health, today launched an initiative to identify genetic alterations that make people susceptible to prostate and breast cancer, two of the most commonly diagnosed cancers in the United States. Cancer Genetic Markers of Susceptibility (CGEMS) is a three-year initiative, funded for $14 million, that will conduct scans of the entire human genome (genotyping) to identify common, inherited gene mutations that increase the risks for breast and prostate cancer.

  9. Organometallic Iridium(III) Anticancer Complexes with New Mechanisms of Action: NCI-60 Screening, Mitochondrial Targeting, and Apoptosis

    PubMed Central

    2013-01-01

    Platinum complexes related to cisplatin, cis-[PtCl2(NH3)2], are successful anticancer drugs; however, other transition metal complexes offer potential for combating cisplatin resistance, decreasing side effects, and widening the spectrum of activity. Organometallic half-sandwich iridium (IrIII) complexes [Ir(Cpx)(XY)Cl]+/0 (Cpx = biphenyltetramethylcyclopentadienyl and XY = phenanthroline (1), bipyridine (2), or phenylpyridine (3)) all hydrolyze rapidly, forming monofunctional G adducts on DNA with additional intercalation of the phenyl substituents on the Cpx ring. In comparison, highly potent complex 4 (Cpx = phenyltetramethylcyclopentadienyl and XY = N,N-dimethylphenylazopyridine) does not hydrolyze. All show higher potency toward A2780 human ovarian cancer cells compared to cisplatin, with 1, 3, and 4 also demonstrating higher potency in the National Cancer Institute (NCI) NCI-60 cell-line screen. Use of the NCI COMPARE algorithm (which predicts mechanisms of action (MoAs) for emerging anticancer compounds by correlating NCI-60 patterns of sensitivity) shows that the MoA of these IrIII complexes has no correlation to cisplatin (or oxaliplatin), with 3 and 4 emerging as particularly novel compounds. Those findings by COMPARE were experimentally probed by transmission electron microscopy (TEM) of A2780 cells exposed to 1, showing mitochondrial swelling and activation of apoptosis after 24 h. Significant changes in mitochondrial membrane polarization were detected by flow cytometry, and the potency of the complexes was enhanced ca. 5× by co-administration with a low concentration (5 ?M) of the ?-glutamyl cysteine synthetase inhibitor L-buthionine sulfoximine (L-BSO). These studies reveal potential polypharmacology of organometallic IrIII complexes, with MoA and cell selectivity governed by structural changes in the chelating ligands. PMID:23618382

  10. El Centro para la Salud Mundial del NCI anuncia las primeras becas de investigación para apoyar las tecnologías portátiles

    Cancer.gov

    El Centro para la Salud Mundial del NCI (CGH) anunció el otorgamiento de subvenciones que apoyarán el desarrollo y la validación de tecnologías portátiles y de bajo costo. Estas tecnologías tienen el potencial de mejorar la detección temprana, el diagnóstico y los tratamientos no invasivos o mínimamente invasivos de varios tipos de cáncer con una prevalencia particularmente alta en ciertos países con economías de ingreso bajo y mediano.

  11. mRNA and microRNA expression profiles of the NCI-60 integrated with drug activities.

    PubMed

    Liu, Hongfang; D'Andrade, Petula; Fulmer-Smentek, Stephanie; Lorenzi, Philip; Kohn, Kurt W; Weinstein, John N; Pommier, Yves; Reinhold, William C

    2010-05-01

    As part of the Spotlight on Molecular Profiling series, we present here new profiling studies of mRNA and microRNA expression for the 60 cell lines of the National Cancer Institute (NCI) Developmental Therapeutics program (DTP) drug screen (NCI-60) using the 41,000-probe Agilent Whole Human Genome Oligo Microarray and the 15,000-feature Agilent Human microRNA Microarray V2. The expression levels of approximately 21,000 genes and 723 human microRNAs were measured. These profiling studies include quadruplicate technical replicates for six and eight cell lines for mRNA and microRNA, respectively, and duplicates for the remaining cell lines. The resulting data sets are freely available and searchable online in our CellMiner database. The result indicates high reproducibility for both platforms and an essential biological similarity across the various cell types. The mRNA and microRNA expression levels were integrated with our previously published 1,429-compound database of anticancer activity obtained from the NCI DTP drug screen. Large blocks of both mRNAs and microRNAs were identified with predominately unidirectional correlations to approximately 1,300 drugs, including 121 drugs with known mechanisms of action. The data sets presented here will facilitate the identification of groups of mRNAs, microRNAs, and drugs that potentially affect and interact with one another. PMID:20442302

  12. Highlights of recent developments and trends in cancer nanotechnology research--view from NCI Alliance for Nanotechnology in Cancer.

    PubMed

    Hull, L C; Farrell, D; Grodzinski, P

    2014-01-01

    Although the incidence of cancer and cancer related deaths in the United States has decreased over the past two decades due to improvements in early detection and treatment, cancer still is responsible for a quarter of the deaths in this country. There is much room for improvement on the standard treatments currently available and the National Cancer Institute (NCI) has recognized the potential for nanotechnology and nanomaterials in this area. The NCI Alliance for Nanotechnology in Cancer was formed in 2004 to support multidisciplinary researchers in the application of nanotechnology to cancer diagnosis and treatment. The researchers in the Alliance have been productive in generating innovative solutions to some of the central issues of cancer treatment including how to detect tumors earlier, how to target cancer cells specifically, and how to improve the therapeutic index of existing chemotherapies and radiotherapy treatments. Highly creative ideas are being pursued where novelty in nanomaterial development enables new modalities of detection or therapy. This review highlights some of the innovative materials approaches being pursued by researchers funded by the NCI Alliance. Their discoveries to improve the functionality of nanoparticles for medical applications includes the generation of new platforms, improvements in the manufacturing of nanoparticles and determining the underlying reasons for the movement of nanoparticles in the blood. PMID:23948249

  13. Observations by a University Anatomy Teacher and a Suggestion for Curricular Change: Integrative Anatomy for Undergraduates

    ERIC Educational Resources Information Center

    Darda, David M.

    2010-01-01

    The observation that anatomical course offerings have decreased in undergraduate biology curricula is supported by a survey of undergraduate institutions in the state of Washington. This reduction, due partially to increased emphasis in other areas of the biology curriculum, along with the lack of anatomy prerequisites for admission to most…

  14. The Virtual Anatomy Laboratory: Usability Testing to Improve an Online Learning Resource for Anatomy Education

    ERIC Educational Resources Information Center

    Doubleday, Eldridge G.; O'Loughlin, Valerie D.; Doubleday, Alison F.

    2011-01-01

    An increasing number of instructors are seeking to provide students with online anatomy resources. Many researchers have attempted to identify associations between resource use and student learning but few studies discuss the importance of usability testing in resource design and modification. Usability testing provides information about ease of…

  15. "Digit Anatomy": A New Technique for Learning Anatomy Using Motor Memory

    ERIC Educational Resources Information Center

    Oh, Chang-Seok; Won, Hyung-Sun; Kim, Kyong-Jee; Jang, Dong-Su

    2011-01-01

    Gestural motions of the hands and fingers are powerful tools for expressing meanings and concepts, and the nervous system has the capacity to retain multiple long-term motor memories, especially including movements of the hands. We developed many sets of successive movements of both hands, referred to as "digit anatomy," and made students practice…

  16. An ontology of human developmental anatomy

    PubMed Central

    Hunter, Amy; Kaufman, Matthew H; McKay, Angus; Baldock, Richard; Simmen, Martin W; Bard, Jonathan B L

    2003-01-01

    Human developmental anatomy has been organized as structured lists of the major constituent tissues present during each of Carnegie stages 1–20 (E1–E50, ?8500 anatomically defined tissue items). For each of these stages, the tissues have been organized as a hierarchy in which an individual tissue is catalogued as part of a larger tissue. Such a formal representation of knowledge is known as an ontology and this anatomical ontology can be used in databases to store, organize and search for data associated with the tissues present at each developmental stage. The anatomical data for compiling these hierarchies comes from the literature, from observations on embryos in the Patten Collection (Ann Arbor, MI, USA) and from comparisons with mouse tissues at similar stages of development. The ontology is available in three versions. The first gives hierarchies of the named tissues present at each Carnegie stage (http://www.ana.ed.ac.uk/anatomy/database/humat/) and is intended to help analyse both normal and abnormal human embryos; it carries hyperlinked notes on some ambiguities in the literature that have been clarified through analysing sectioned material. The second contains many additional subsidiary tissue domains and is intended for handling tissue-associated data (e.g. gene-expression) in a database. This version is available at the humat site and at http://genex.hgu.mrc.ac.uk/Resources/intro.html/), and has been designed to be interoperable with the ontology for mouse developmental anatomy, also available at the genex site. The third gives the second version in GO ontology syntax (with standard IDs for each tissue) and can be downloaded from both the genex and the Open Biological Ontology sites (http://obo.sourceforge.net/) PMID:14620375

  17. Predicting enzyme targets for cancer drugs by profiling human Metabolic reactions in NCI-60 cell lines

    PubMed Central

    2010-01-01

    Background Drugs can influence the whole metabolic system by targeting enzymes which catalyze metabolic reactions. The existence of interactions between drugs and metabolic reactions suggests a potential way to discover drug targets. Results In this paper, we present a computational method to predict new targets for approved anti-cancer drugs by exploring drug-reaction interactions. We construct a Drug-Reaction Network to provide a global view of drug-reaction interactions and drug-pathway interactions. The recent reconstruction of the human metabolic network and development of flux analysis approaches make it possible to predict each metabolic reaction's cell line-specific flux state based on the cell line-specific gene expressions. We first profile each reaction by its flux states in NCI-60 cancer cell lines, and then propose a kernel k-nearest neighbor model to predict related metabolic reactions and enzyme targets for approved cancer drugs. We also integrate the target structure data with reaction flux profiles to predict drug targets and the area under curves can reach 0.92. Conclusions The cross validations using the methods with and without metabolic network indicate that the former method is significantly better than the latter. Further experiments show the synergism of reaction flux profiles and target structure for drug target prediction. It also implies the significant contribution of metabolic network to predict drug targets. Finally, we apply our method to predict new reactions and possible enzyme targets for cancer drugs. PMID:20932284

  18. NCI Think Tank Concerning the Identifiability of Biospecimens and “-Omic” Data

    PubMed Central

    Weil, Carol J.; Mechanic, Leah E.; Green, Tiffany; Kinsinger, Christopher; Lockhart, Nicole C.; Nelson, Stefanie A.; Rodriguez, Laura L.; Buccini, Laura D.

    2014-01-01

    On June 11 and 12, 2012, the National Cancer Institute (NCI) hosted a think tank concerning the identifiability of biospecimens and “omic” Data in order to explore challenges surrounding this complex and multifaceted topic. The think tank brought together forty-six leaders from several fields, including cancer genomics, bioinformatics, human subject protection, patient advocacy, and commercial genetics. The first day involved presentations regarding the state of the science of re-identification; current and proposed regulatory frameworks for assessing identifiability; developments in law, industry and biotechnology; and the expectations of patients and research participants. The second day was spent by think tank participants in small break-out groups designed to address specific sub-topics under the umbrella issue of identifiability, including considerations for the development of best practices for data sharing and consent, and targeted opportunities for further empirical research. We describe the outcomes of this two day meeting, including two complimentary themes that emerged from moderated discussions following the presentations on Day 1, and ideas presented for further empirical research to discern the preferences and concerns of research participants about data sharing and individual identifiability. PMID:23579437

  19. An Ensemble Based Top Performing Approach for NCI-DREAM Drug Sensitivity Prediction Challenge

    PubMed Central

    Wan, Qian; Pal, Ranadip

    2014-01-01

    We consider the problem of predicting sensitivity of cancer cell lines to new drugs based on supervised learning on genomic profiles. The genetic and epigenetic characterization of a cell line provides observations on various aspects of regulation including DNA copy number variations, gene expression, DNA methylation and protein abundance. To extract relevant information from the various data types, we applied a random forest based approach to generate sensitivity predictions from each type of data and combined the predictions in a linear regression model to generate the final drug sensitivity prediction. Our approach when applied to the NCI-DREAM drug sensitivity prediction challenge was a top performer among 47 teams and produced high accuracy predictions. Our results show that the incorporation of multiple genomic characterizations lowered the mean and variance of the estimated bootstrap prediction error. We also applied our approach to the Cancer Cell Line Encyclopedia database for sensitivity prediction and the ability to extract the top targets of an anti-cancer drug. The results illustrate the effectiveness of our approach in predicting drug sensitivity from heterogeneous genomic datasets. PMID:24978814

  20. Nonlinear Quantitative Radiation Sensitivity Prediction Model Based on NCI-60 Cancer Cell Lines

    PubMed Central

    Zhang, Chunying; Girard, Luc; Das, Amit; Chen, Sun; Zheng, Guangqiang

    2014-01-01

    We proposed a nonlinear model to perform a novel quantitative radiation sensitivity prediction. We used the NCI-60 panel, which consists of nine different cancer types, as the platform to train our model. Important radiation therapy (RT) related genes were selected by significance analysis of microarrays (SAM). Orthogonal latent variables (LVs) were then extracted by the partial least squares (PLS) method as the new compressive input variables. Finally, support vector machine (SVM) regression model was trained with these LVs to predict the SF2 (the surviving fraction of cells after a radiation dose of 2?Gy ?-ray) values of the cell lines. Comparison with the published results showed significant improvement of the new method in various ways: (a) reducing the root mean square error (RMSE) of the radiation sensitivity prediction model from 0.20 to 0.011; and (b) improving prediction accuracy from 62% to 91%. To test the predictive performance of the gene signature, three different types of cancer patient datasets were used. Survival analysis across these different types of cancer patients strongly confirmed the clinical potential utility of the signature genes as a general prognosis platform. The gene regulatory network analysis identified six hub genes that are involved in canonical cancer pathways. PMID:25032244

  1. Permissivity of the NCI-60 cancer cell lines to oncolytic Vaccinia Virus GLV-1h68

    PubMed Central

    2011-01-01

    Background Oncolytic viral therapy represents an alternative therapeutic strategy for the treatment of cancer. We previously described GLV-1h68, a modified Vaccinia Virus with exclusive tropism for tumor cells, and we observed a cell line-specific relationship between the ability of GLV-1h68 to replicate in vitro and its ability to colonize and eliminate tumor in vivo. Methods In the current study we surveyed the in vitro permissivity to GLV-1h68 replication of the NCI-60 panel of cell lines. Selected cell lines were also tested for permissivity to another Vaccinia Virus and a vesicular stomatitis virus (VSV) strain. In order to identify correlates of permissity to viral infection, we measured transcriptional profiles of the cell lines prior infection. Results We observed highly heterogeneous permissivity to VACV infection amongst the cell lines. The heterogeneity of permissivity was independent of tissue with the exception of B cell derivation. Cell lines were also tested for permissivity to another Vaccinia Virus and a vesicular stomatitis virus (VSV) strain and a significant correlation was found suggesting a common permissive phenotype. While no clear transcriptional pattern could be identified as predictor of permissivity to infection, some associations were observed suggesting multifactorial basis permissivity to viral infection. Conclusions Our findings have implications for the design of oncolytic therapies for cancer and offer insights into the nature of permissivity of tumor cells to viral infection. PMID:22011439

  2. PANCREATITIS - DIABETES - PANCREATIC CANCER: Summary of an NIDDK-NCI Workshop

    PubMed Central

    Andersen, Dana K.; Andren-Sandberg, Åke; Duell, Eric J.; Goggins, Michael; Korc, Murray; Petersen, Gloria M.; Smith, Jill P.; Whitcomb, David C.

    2013-01-01

    A workshop sponsored by the NIDDK and the NCI on “Pancreatitis-Diabetes-Pancreatic Cancer” focused on the risk factors of chronic pancreatitis (CP) and diabetes mellitus (DM) on the development of pancreatic ductal adenocarcinoma (PDAC). Sessions were held on a) an overview of the problem of PDAC, b) CP as a risk factor for PDAC, c) DM as a risk factor for PDAC, d) pancreatogenic, or type 3c DM (T3cDM), e) genomic associations of CP, DM, and PDAC, f) surveillance of high-risk populations and early detection of PDAC, and g) effects of DM treatment on PDAC. Recent data and current understandings of the mechanisms of CP- and DM-associated factors on PDAC development were discussed, and a detailed review of the possible risks of DM treatment on the development of PDAC was provided by representatives from academia, industry, and the Food and Drug Administration. The current status of possible biomarkers of PDAC and surveillance strategies for high-risk populations were discussed, and the gaps in knowledge and opportunities for further research were elucidated. A broad spectrum of expertise of the speakers and discussants provided an unusually productive workshop, the highlights of which are summarized in the accompanying article. PMID:24152948

  3. Lumbar vertebral pedicles: radiologic anatomy and pathology.

    PubMed

    Patel, N P; Kumar, R; Kinkhabwala, M; Wengrover, S I

    1988-01-01

    With the advancement of high-resolution computed tomography (CT) scanning the spine has added new knowledge to the various conditions affecting the pedicles. We wish to review the entire spectrum of pedicular lesions: the embryology, normal anatomy, normal variants, pitfalls, congenital anomalies, and pathological conditions are discussed. Different imaging modalities involving CT, isotope bone scanning, and Magnetic Resonance Imaging (MRI) are used to complement plain films of the lumbar spine. This subject review is an excellent source for future reference to lumbar pedicular lesions. PMID:3293918

  4. The flexible adult flatfoot: anatomy and pathomechanics.

    PubMed

    Walters, Jeremy L; Mendicino, Samuel S

    2014-07-01

    Adult acquired flatfoot deformity is generally associated with a collapsing medial longitudinal arch and progressive loss of strength of the tibialis posterior tendon. It is most commonly associated with posterior tibial tendon dysfunction that can have an arthritic or traumatic cause. With an increasing population of obese patients, the often misdiagnosed and overlooked posterior tibial tendon dysfunction will only continue to present more often in the foot and ankle specialist's office. This article focuses on the anatomy, classification, and pathomechanics of the flexible adult flatfoot. PMID:24980923

  5. Student-Directed Fresh Tissue Anatomy Course for Physician Assistants

    ERIC Educational Resources Information Center

    McBride, Jennifer M.; Drake, Richard L.

    2011-01-01

    Healthcare providers in all areas and levels of education depend on their knowledge of anatomy for daily practice. As educators, we are challenged with teaching the anatomical sciences in creative, integrated ways and often within a condensed time frame. This article describes the organization of a clinical anatomy course with a peer taught…

  6. Cranial pneumatic anatomy of Ornithomimus edmontonicus (Ornithomimidae: Theropoda)

    Microsoft Academic Search

    Rui Tahara; Hans C. E. Larsson

    2011-01-01

    Modern archosaurs have extensive pneumatic diverticula originating from paranasal and tympanic sinuses. This complex anatomy is present in many fossil archosaurs, but few descriptions of the complete cranial pneumatic system exist. The cranial pneumatic morphology of birds and non-avian theropods are the best studied, but complete description of this anatomy for an ornithomimid was lacking. We describe the cranial pneumaticity

  7. 9 Clarifying the functional neuro-anatomy of face

    E-print Network

    Rossion, Bruno

    9 Clarifying the functional neuro-anatomy of face perception by single case neuroimaging studies a reformulation of current hierarchical neuro-functional models of face identity processing. Initial studies in a single-case approach can greatly contribute to our understanding of the neuro-anatomy of face

  8. Measuring Change in Professionalism Attitudes during the Gross Anatomy Course

    ERIC Educational Resources Information Center

    Pearson, William G., Jr.; Hoagland, Todd M.

    2010-01-01

    By design or default, anatomy educators are often responsible for introducing students to medical professionalism. Although much has been said about the role of anatomical education, there are no published reports suggesting how to measure change. This study investigated what professionalism attitudes, if any, change during a gross anatomy course.…

  9. The 2007 Anatomy Ceremony: A Service of Gratitude

    PubMed Central

    2008-01-01

    Yale University medical and PA students, classes of 2010 and 2008 respectively, express their gratitude in a compilation of reflections on learning human anatomy. In coordination with the Section of Anatomy and Experimental Surgery at the School of Medicine, the Yale Journal of Biology and Medicine encourages you to hear the stories of the body as narrated by the student.

  10. GEOL 104 Dinosaurs: A Natural History Anatomy and Taxonomy Assignment

    E-print Network

    Holtz Jr., Thomas R.

    Name: 1 GEOL 104 Dinosaurs: A Natural History Anatomy and Taxonomy Assignment DUE: Fri. Sept. 29 Part I. Comparative Anatomy Below is the skull of the early primitive meat-eating dinosaur 25) Ulna 26) A Metacarpal 27) A Metatarsal 28) Chevron 29) Acetabulum Extra Credit) This dinosaur

  11. Statistical Computing on Manifolds: From Riemannian Geometry to Computational Anatomy

    Microsoft Academic Search

    Xavier Pennec

    2008-01-01

    Computational anatomy is an emerging discipline that aims at analyzing and modeling the individual anatomy of organs and their bi- ological variability across a population. The goal is not only to model the normal variations among a population, but also discover morphological differences between normal and pathological populations, and possibly to detect, model and classify the pathologies from structural abnormali-

  12. Using Multimedia and Web3D to Enhance Anatomy Teaching

    ERIC Educational Resources Information Center

    Brenton, Harry; Hernandez, Juan; Bello, Fernando; Strutton, Paul; Purkayastha, Sanjay; Firth, Tony; Darzi, Ara

    2007-01-01

    Anatomy teaching is undergoing significant changes due to time constraints, limited availability of cadavers and technological developments in the areas of three-dimensional modelling and computer-assisted learning. This paper gives an overview of methods used to teach anatomy to undergraduate medical students and discusses the educational…

  13. The Molecular Anatomy of Spontaneous Germline Mutations in Human Testes

    E-print Network

    Nachman, Michael

    The Molecular Anatomy of Spontaneous Germline Mutations in Human Testes Jian Qin1[¤ , Peter, Shinde DN, Yoon SR, et al. (2007) The molecular anatomy of spontaneous germline mutations in human testes syndrome mutation (C755G) in the human fibroblast growth factor receptor 2 gene (FGFR2) is 100­1,000 times

  14. The importance of spatial ability and mental models in learning anatomy

    NASA Astrophysics Data System (ADS)

    Chatterjee, Allison K.

    As a foundational course in medical education, gross anatomy serves to orient medical and veterinary students to the complex three-dimensional nature of the structures within the body. Understanding such spatial relationships is both fundamental and crucial for achievement in gross anatomy courses, and is essential for success as a practicing professional. Many things contribute to learning spatial relationships; this project focuses on a few key elements: (1) the type of multimedia resources, particularly computer-aided instructional (CAI) resources, medical students used to study and learn; (2) the influence of spatial ability on medical and veterinary students' gross anatomy grades and their mental models; and (3) how medical and veterinary students think about anatomy and describe the features of their mental models to represent what they know about anatomical structures. The use of computer-aided instruction (CAI) by gross anatomy students at Indiana University School of Medicine (IUSM) was assessed through a questionnaire distributed to the regional centers of the IUSM. Students reported using internet browsing, PowerPoint presentation software, and email on a daily bases to study gross anatomy. This study reveals that first-year medical students at the IUSM make limited use of CAI to study gross anatomy. Such studies emphasize the importance of examining students' use of CAI to study gross anatomy prior to development and integration of electronic media into the curriculum and they may be important in future decisions regarding the development of alternative learning resources. In order to determine how students think about anatomical relationships and describe the features of their mental models, personal interviews were conducted with select students based on students' ROT scores. Five typologies of the characteristics of students' mental models were identified and described: spatial thinking, kinesthetic approach, identification of anatomical structures, problem solving strategies, and study methods. Students with different levels of spatial ability visualize and think about anatomy in qualitatively different ways, which is reflected by the features of their mental models. Low spatial ability students thought about and used two-dimensional images from the textbook. They possessed basic two-dimensional models of anatomical structures; they placed emphasis on diagrams and drawings in their studies; and they re-read anatomical problems many times before answering. High spatial ability students thought fully in three-dimensional and imagined rotation and movement of the structures; they made use of many types of images and text as they studied and solved problems. They possessed elaborate three-dimensional models of anatomical structures which they were able to manipulate to solve problems; and they integrated diagrams, drawings, and written text in their studies. Middle spatial ability students were a mix between both low and high spatial ability students. They imagined two-dimensional images popping out of the flat paper to become more three-dimensional, but still relied on drawings and diagrams. Additionally, high spatial ability students used a higher proportion of anatomical terminology than low spatial ability or middle spatial ability students. This provides additional support to the premise that high spatial students' mental models are a complex mixture of imagistic representations and propositional representations that incorporate correct anatomical terminology. Low spatial ability students focused on the function of structures and ways to group information primarily for the purpose of recall. This supports the theory that low spatial students' mental models will be characterized by more on imagistic representations that are general in nature. (Abstract shortened by UMI.)

  15. Anatomy and Physiology. Module Set I: Introduction to Anatomy and Physiology. Teacher Edition [and] Student Edition. Surgical Technology.

    ERIC Educational Resources Information Center

    Hilley, Robert

    This document, which is the first part in a two-part set of modules on anatomy and physiology for future surgical technicians, contains the teacher and student editions of an introduction to anatomy and physiology that consists of modules on the following topics: (1) organization of the human body; (2) biochemistry and microbiology; (3) infection,…

  16. Virtual Reality Anatomy: Is It Comparable with Traditional Methods in the Teaching of Human Forearm Musculoskeletal Anatomy?

    ERIC Educational Resources Information Center

    Codd, Anthony M.; Choudhury, Bipasha

    2011-01-01

    The use of cadavers to teach anatomy is well established, but limitations with this approach have led to the introduction of alternative teaching methods. One such method is the use of three-dimensional virtual reality computer models. An interactive, three-dimensional computer model of human forearm anterior compartment musculoskeletal anatomy

  17. FMA-RadLex: An Application Ontology of Radiological Anatomy derived from the Foundational Model of Anatomy Reference Ontology

    E-print Network

    Rubin, Daniel L.

    FMA-RadLex: An Application Ontology of Radiological Anatomy derived from the Foundational Model of Anatomy Reference Ontology Jose L.V. Mejino Jr, MD1 , Daniel L. Rubin, MD, MS3 and James F. Brinkley, MD reference ontologies are being developed to serve as generalizable and reusable sources designed to support

  18. Normal shoulder ultrasound: anatomy and technique.

    PubMed

    Gupta, Harun; Robinson, Philip

    2015-07-01

    Shoulder ultrasound (US) is one of the most common applications of musculoskeletal US due to the high incidence of rotator cuff disorders. It can be used effectively for the diagnosis of rotator cuff diseases, and several studies have shown very high sensitivity and specificity for rotator cuff tears comparable with that of MRI. Shoulder US has several advantages over MRI such as lower cost, comparatively easier availability, short examination duration, dynamic capability, and ability to perform guided injection at the same appointment. However, it depends on the skill of the operator and therefore requires a standardized detailed protocol to avoid errors in diagnosis. A symptomatic area-only focused examination should not be performed because it is not uncommon to have symptoms away from the actual site of pathology. Detailed understanding of what anatomy can be evaluated is required, and this article discusses the relevant anatomy covering the rotator cuff, subacromial bursa, and acromioclavicular joint. The equipment requirements and technique of examination of different anatomical structures with transducer positions and normal sonographic appearances are described. Pitfalls and artifacts associated with shoulder US are covered; understanding them is crucial to avoid misinterpretation of findings. PMID:26021582

  19. Anatomy, biogenesis, and regeneration of salivary glands

    PubMed Central

    Holmberg, Kyle V.; Hoffman, Matthew P.

    2014-01-01

    An overview of the anatomy and biogenesis of salivary glands is important in order to understand the physiology, functions and disorders associated with saliva. A major disorder of salivary glands is salivary hypofunction and resulting xerostomia, or dry mouth, which affects hundreds of thousands of patients per year who suffer from salivary gland diseases or undergo head and neck cancer treatment. There is currently no curative therapy for these patients. To improve these patients’ quality of life, new therapies are being developed based on findings in salivary gland cell and developmental biology. Here we discuss the anatomy and biogenesis of the major human salivary glands and the rodent submandibular gland (SMG), which has been used extensively as a research model. We also include a review of recent research on the identification and function of stem cells in salivary glands, and the emerging field of research suggesting nerves play an instructive role during development and may be essential for adult gland repair and regeneration. Understanding the molecular mechanisms involved in gland biogenesis provides a template for regenerating, repairing or reengineering diseased or damaged adult human salivary glands. We provide an overview of three general approaches currently being developed to regenerate damaged salivary tissue, including gene therapy, stem cell-based therapy, and tissue engineering. In the future, it may be that a combination of all three will be used to repair, regenerate and reengineer functional salivary glands in patients to increase the secretion of their saliva, the focus of this monograph. PMID:24862590

  20. Animating functional anatomy for the web.

    PubMed

    Guttmann, G D

    2000-04-15

    The instructor sometimes has a complex task in explaining the concepts of functional anatomy and embryology to health professional students. However, animations can easily illustrate functional anatomy, clinical procedures, or the developing embryo. Web animation increases the accessibility of this information and makes it much more useful for independent student learning. A modified version of the animation can also be used for patient education. This article defines animation, provides a brief history of animation, discusses the principles of animation, illustrates and evaluates some of the video-editing or movie-making computer software programs, and shows examples of two of the author's animations. These two animations are the inferior alveolar nerve block from the mandibular nerve anesthetics unit and normal temporomandibular joint (TMJ) function from the muscles of the mastication and the TMJ function unit. The software discussed are the industry leaders and have made the job of producing computer-based animations much easier. The programs are Adobe Premiere, Adobe After Effects, Apple QuickTime and Macromedia Flash . PMID:10815810

  1. Obturator hernia: anatomy, embryology, diagnosis, and treatment.

    PubMed

    Petrie, Alison; Tubbs, R Shane; Matusz, Petru; Shaffer, Kitt; Loukas, Marios

    2011-07-01

    An obturator hernia is an infrequent but significant cause of intestinal obstruction. The incidence of obturator hernias is between 0.05 and 1.4% of all hernias. The mortality rate can be as high as 70% when acutely incarcerated due to the difficulty in diagnosis and delay in surgical treatment Three progressive stages of obturator herniation have been classified and can be one of three different varieties depending on the pathway the herniated sac follows. Knowledge of the anatomy and pathogenesis of obturator herniation is essential in diagnosis and treatment. The most common clinical presentation is intestinal obstruction (90%) and this is often seen in elderly, emaciated, multiparous women with predisposing conditions. Other classic signs, though not always present include obturator neuralgia, the Howship-Romberg sign and the Hannington-Kiff sign. Computed tomography scan is the most favored diagnostic imaging method. The abdominal surgical approach is most preferred when a diagnosis is uncertain and laparoscopy should be employed in elective early surgeries. This aim of this article is to review the diagnosis and treatment of obturator hernia by describing the anatomy, embryology, clinical presentation, diagnosis, and management currently in use. Increased awareness and proper management of this condition will result in decreased morbidity and mortality. PMID:21322061

  2. Computational Anatomy Atlas ofthe Heart Sebastian Ordas, Estanislao Oubel, Rafael Sebastian and Alejadro F. Frangi

    E-print Network

    Frangi, Alejandro

    Computational Anatomy Atlas ofthe Heart Sebastian Ordas, Estanislao Oubel, Rafael Sebastian. The present work aims at providing a common anatomi- A computational anatomy atlas of the heart has been built cal domain, or anatomy atlas, on top ofwhich diverse struc- for the main purposes ofpatient

  3. Design Features of On-Line Anatomy Information Resources: A Comparison with the Digital Anatomist

    E-print Network

    Washington at Seattle, University of

    . In addition to videodisks and CD-ROMs, hundreds of anatomy web sites present Visible Human and other1 Design Features of On-Line Anatomy Information Resources: A Comparison with the Digital Anatomist for learning and teaching anatomy as medical students, and have also examined available anatomy web sites

  4. Syllabus Human Anatomy -Biol 253 Fall 2012 page 1 of 8

    E-print Network

    Houde, Peter

    Syllabus Human Anatomy - Biol 253 Fall 2012 page 1 of 8 Welcome to Human Anatomy! The intent previous years copies of all handouts distributed in class Corequisites: Biol 253 Human Anatomy and Biol 253L Human Anatomy Laboratory are corequisites. One cannot be taken without the other. YOU MUST

  5. Physician Opinions About an Anatomy Core Curriculum: A Case for Medical Imaging and Vertical Integration

    E-print Network

    was to assess the importance of a human gross anatomy course by soliciting the opinions of physicians fromPhysician Opinions About an Anatomy Core Curriculum: A Case for Medical Imaging and Vertical and Anatomy, the University of Chicago, Chicago, Illinois Pre-clinical anatomy curricula must provide medical

  6. The reverse effect of X-ray irradiation on acquired gefitinib resistance in non-small cell lung cancer cell line NCI-H1975 in vitro.

    PubMed

    Wang, Jing; Wei, Hong; Zhao, Baoxia; Li, Mei; Lv, Weipeng; Lv, Ling; Song, Bo; Lv, Shen

    2014-12-01

    The clinical efficacy of gefitinib in the treatment of non-small cell lung cancer (NSCLC) with mutations in exon 18, 19 or 21 of epidermal growth factor receptor (EGFR) is limited by the acquired resistance to the drug. To explore whether X-ray irradiation could reverse the acquired gefitinib resistance in NSCLC cell in vitro. We chose a human NSCLC cell line NCI-H1975 to establish acquired gefitinib-resistant cell line named as NCI-H1975/GR. NCI-H1975/GR was irradiated with X-ray and then named as NCI-H1975/GR/XR. In the three cell lines, subsequently cell growth curves and cell population doubling time were calculated by cell proliferation assay, the changes of cell viability were evaluated by trypan blue dye exclusion method and MTT assay, the cell cycle distribution and apoptosis were investigated by flow cytometry, the expressions of E-cadherin and vimentin used to indicate epithelial-mesenchymal transition (EMT) were determined by western blot analysis, the protein expressions in EGFR/KRAS/BRAF transduction pathway were detected by immunocytochemistry, and the mutations of EGFR, KRAS and BRAF were detected by high resolution melting analysis and direct sequencing. We found that the X-ray irradiation enhanced the growth inhibitory effects of gefitinib on the acquired gefitinib-resistant cell line. Of NCI-H1975/GR/XR following gefitinib treatment, the IC50 decreased significantly, the cell proportion of phase G0/G1 was slightly higher, and the apoptosis cell proportion was significantly higher than those of NCI-H1975/GR. In addition, the reversal of EMT being present in NCI-H1975/GR cells was likely appearing in NCI-H1975/GR/XR cells. These results indicated that the acquired gefitinib resistance could be reversed by X-ray irradiation in NSCLC cell line NCI-H1975 harboring both the L858R and T790M mutation in vitro. PMID:25008024

  7. Anatomy in occupational therapy program curriculum: practitioners' perspectives.

    PubMed

    Schofield, Katherine Anne

    2014-01-01

    Anatomy education is undergoing significant transformation. It is unknown whether changes are in accordance with occupational therapy (OT) practice needs. The purpose of this pilot study was to survey OT clinicians to determine their perspectives on the value of anatomy in OT curricula, and anatomical knowledge required for practice. In addition to demographics, the survey asked questions on the value of a standalone anatomy course, integration of anatomical content in other coursework, practice areas requiring anatomy knowledge, course content, teaching media recommendations, and their opinions regarding whether graduates have adequate anatomy knowledge for competent practice. Surveys were distributed to OT practitioners in the state of Arizona (n = 107). Response rate was 51% on electronic surveys, 29% on mailed surveys. All respondents recommended an anatomy course in OT curricula; 97% as a standalone course with integration of course content throughout the curriculum. The most recommended teaching method was cadaver dissection. Content areas identified as important to cover included skeletal, muscular, and nervous systems. Regions recommended were the upper limb, thorax/trunk, head and neck, and lower limb. Practice areas requiring anatomy knowledge included joint range of motion and strengthening treatment interventions, goniometry, muscle strength testing, assessing muscle tone, wheelchair assessment/prescription, orthotics, physical agent modalities, and activity adaptation. Eighty-one percent felt that entry-level practitioners had adequate knowledge for competent practice. This study supports inclusion of a separate anatomy course in OT curricula, continued use of cadavers, and the importance of including input from practicing clinicians when determining anatomy course content. PMID:23804536

  8. Diffeomorphometry and geodesic positioning systems for human anatomy

    PubMed Central

    Miller, Michael I.; Younes, Laurent; Trouvé, Alain

    2014-01-01

    The Computational Anatomy project has largely been a study of large deformations within a Riemannian framework as an efficient point of view for generating metrics between anatomical configurations. This approach turns D’Arcy Thompson’s comparative morphology of human biological shape and form into a metrizable space. Since the metric is constructed based on the geodesic length of the flows of diffeomorphisms connecting the forms, we call it diffeomorphometry. Just as importantly, since the flows describe algebraic group action on anatomical submanifolds and associated functional measurements, they become the basis for positioning information, which we term geodesic positioning. As well the geodesic connections provide Riemannian coordinates for locating forms in the anatomical orbit, which we call geodesic coordinates. These three components taken together — the metric, geodesic positioning of information, and geodesic coordinates — we term the geodesic positioning system. We illustrate via several examples in human and biological coordinate systems and machine learning of the statistical representation of shape and form. PMID:24904924

  9. Integrating anatomy and function for zebrafish circuit analysis.

    PubMed

    Arrenberg, Aristides B; Driever, Wolfgang

    2013-01-01

    Due to its transparency, virtually every brain structure of the larval zebrafish is accessible to light-based interrogation of circuit function. Advanced stimulation techniques allow the activation of optogenetic actuators at different resolution levels, and genetically encoded calcium indicators report the activity of a large proportion of neurons in the CNS. Large datasets result and need to be analyzed to identify cells that have specific properties-e.g., activity correlation to sensory stimulation or behavior. Advances in three-dimensional (3D) functional mapping in zebrafish are promising; however, the mere coordinates of implicated neurons are not sufficient. To comprehensively understand circuit function, these functional maps need to be placed into the proper context of morphological features and projection patterns, neurotransmitter phenotypes, and key anatomical landmarks. We discuss the prospect of merging functional and anatomical data in an integrated atlas from the perspective of our work on long-range dopaminergic neuromodulation and the oculomotor system. We propose that such a resource would help researchers to surpass current hurdles in circuit analysis to achieve an integrated understanding of anatomy and function. PMID:23630469

  10. [Osseous vascular anatomy in the hand and wrist].

    PubMed

    Fontaine, C; Wavreille, G; Aumar, A; Bry, R; Demondion, X

    2010-12-01

    The design and the realization of vascularized osseous grafts at the hand and the wrist require a precise knowledge of the general and regional anatomy. This article gives first a progress report on current knowledge about the general organization of arterial and venous vascularization, of the long bones (number and localization of the nutrient foramina, communication between the epiphyseo-metaphyseal and diaphyseal networks) and of the short bones, in the adult and the child, before the closing of the growth plate. The general organization of arterial vascularization of the hand and the wrist is pointed out, with the current nomenclature and the contribution of the recent publications, in particular in these, which relate to the distal extremity of the radius. The vascularization of each bone (radius and ulna, carpal bones, metacarpals and phalanges) is then described; making way, the anatomical bases of each vascularized bone graft, which can be harvested there, are described. The last technical projections are included, in particular the realization of the reverse flow vascularized bone grafts harvested from the metacarpals. This article still gives a progress report on the osseous vascularization of the short bones, in particular of those which are exposed the most to the osteonecrosis (scaphoid, lunatum). It has the ambition to light the reader and to prepare him (her) with the reading of the following chapters. PMID:21075661

  11. Luteolin exerts an anticancer effect on NCI-H460 human non-small cell lung cancer cells through the induction of Sirt1-mediated apoptosis.

    PubMed

    Ma, Liping; Peng, Hongjun; Li, Kunsheng; Zhao, Runrun; Li, Li; Yu, Yilong; Wang, Xiaoming; Han, Zhifeng

    2015-09-01

    Luteolin is a falconoid compound, which exhibits anticancer properties, however, its contribution to Sirt1-mediated apoptosis in human non-small cell lung cancer remains to be elucidated. The present study confirmed that the anticancer effect of luteolin on NCI?H460 cells was through Sirt1?mediated apoptosis. The NCI?H460 cells were treated with different concentrations of luteolin, and a 3?(4,5?dimethyl?2?thiazolyl)?2,5?diphnyl?2H?tetrazolium bromide assay, cell cycle analysis and annexin?V/fluorescein isothiocyanate and propidium double staining were performed to assess the apoptotic effect of luteolin. Wound healing and Transwell assays were performed to confirm the inhibition of NCI?H460 cell migration. The protein levels of Sirt1 were knocked down in the NCI?H460 cells using a lentivirus to further investigate the role of this protein, and the expression levels of the apoptotic associated proteins, Bad, Bcl?2, Bax, caspase?3 and Sirt1, were measured using western blotting. The results of the present study demonstrated that luteolin exerted an anticancer effect against NCI?H460 cells through Sirt1?mediated apoptosis and the inhibition of cell migration. PMID:26096576

  12. FGFR2 Is Amplified in the NCI-H716 Colorectal Cancer Cell Line and Is Required for Growth and Survival

    PubMed Central

    Mathur, Anjili; Ware, Christopher; Davis, Lenora; Gazdar, Adi; Pan, Bo-Sheng; Lutterbach, Bart

    2014-01-01

    Aberrant kinase activation resulting from mutation, amplification, or translocation can drive growth and survival in a subset of human cancer. FGFR2 is amplified in breast and gastric cancer, and we report here the first characterization of FGFR2 gene amplification in colorectal cancer in the NCI-H716 colorectal cancer cell line. FGFR2 is highly expressed and activated in NCI-H716 cells, and FGFR selective small molecule inhibitors or FGFR2 shRNA strongly inhibited cell viability in vitro, indicating “addiction” of NCI-H716 cells to FGFR2. NCI-H716 growth in a xenograft model was also inhibited by an FGFR small molecule inhibitor. FGFR2 was required for activation of multiple downstream signaling proteins including AKT, ERK, S6RP and NFKB. Inhibition of downstream kinases such as AKT or ERK alone had modest effects on proliferation, whereas combined inhibition of AKT and ERK signaling resulted in a loss of viability similar to FGFR2 inhibition. We identified elevated FGFR2 expression in a small subset of primary colorectal cancer, however FGFR2 amplification was not observed. Although FGFR2 amplification is not common in primary colon cancer or lymph node and liver metastases, other subsets of colorectal cancer such as ascites, from which the NCI-H716 cell line was derived, have yet to be tested. These results suggest that emerging FGFR inhibitor therapeutics may have efficacy in a subset of colon cancer driven by FGFR2 amplification. PMID:24968263

  13. Anatomy integration blueprint: A fourth-year musculoskeletal anatomy elective model.

    PubMed

    Lazarus, Michelle D; Kauffman, Gordon L; Kothari, Milind J; Mosher, Timothy J; Silvis, Matthew L; Wawrzyniak, John R; Anderson, Daniel T; Black, Kevin P

    2014-01-01

    Current undergraduate medical school curricular trends focus on both vertical integration of clinical knowledge into the traditionally basic science-dedicated curricula and increasing basic science education in the clinical years. This latter type of integration is more difficult and less reported on than the former. Here, we present an outline of a course wherein the primary learning and teaching objective is to integrate basic science anatomy knowledge with clinical education. The course was developed through collaboration by a multi-specialist course development team (composed of both basic scientists and physicians) and was founded in current adult learning theories. The course was designed to be widely applicable to multiple future specialties, using current published reports regarding the topics and clinical care areas relying heavily on anatomical knowledge regardless of specialist focus. To this end, the course focuses on the role of anatomy in the diagnosis and treatment of frequently encountered musculoskeletal conditions. Our iterative implementation and action research approach to this course development has yielded a curricular template for anatomy integration into clinical years. Key components for successful implementation of these types of courses, including content topic sequence, the faculty development team, learning approaches, and hidden curricula, were developed. We also report preliminary feedback from course stakeholders and lessons learned through the process. The purpose of this report is to enhance the current literature regarding basic science integration in the clinical years of medical school. PMID:24591484

  14. Michelangelo: anatomy and its implication in his art.

    PubMed

    Hilloowala, Rumy

    2009-06-01

    Michelangelo's major interest was the Life of the Soul as expressed in the beautiful structure and movement of the human body, which he often called the "mortal veil" of the divine intentions. This study ascertains Michelangelo's interest in and acquisition of the knowledge of human anatomy, the use of small anatomical models to crystallize his concepts into reality and the application of anatomy to his art. Relatively little is known of this interaction between anatomy and art in Michelangelo's life and work. PMID:20027756

  15. Case Study: Bad Fish: Human Anatomy and Physiology Edition

    NSDL National Science Digital Library

    James Hewlett (Finger Lakes Community College Science and Technology)

    2003-04-13

    This is a case study for high school and undergraduate students in anatomy, physiology, and/or anatomy and physiology courses. In particular this case study explores anatomy and physiology associated with the nervous system. Users of the National Center for Case Study Teaching in Science will be required to register (free) to gain access to the answer key (and must be of teaching status to receive the key). Included in the resource are the case overview, objectives, case study, teaching notes and answer key.

  16. Data Mining of NCI’s Anticancer Screening Database Reveals Mitochondrial Complex I Inhibitors Cytotoxic to Leukemia Cell Lines

    PubMed Central

    Glover, Constance J.; Rabow, Alfred A.; Isgor, Yasemin G.; Shoemaker, Robert H.; Covell, David G.

    2007-01-01

    Mitochondria are principal mediators of apoptosis and thus can be considered molecular targets for new chemotherapeutic agents in the treatment of cancer. Inhibitors of mitochondrial complex I of the electron transport chain have been shown to induce apoptosis and exhibit antitumor activity. In an effort to find novel complex I inhibitors which exhibited anti-cancer activity in the NCI’s tumor cell line screen, we examined organized tumor cytotoxicity screening data available as SOM (self-organized maps) (http://spheroid.ncifcrf.gov) at the Developmental Therapeutics Program (DTP) of the National Cancer Institute (NCI). Our analysis focused on an SOM cluster comprised of compounds which included a number of known mitochondrial complex I (NADH:CoQ oxidoreductase) inhibitors. From these clusters ten compounds whose mechanism of action was unknown were tested for inhibition of complex I activity in bovine heart submitochondrial particles (SMP) resulting in the discovery that five of the ten compounds demonstrated significant inhibition with IC50's in the nM range for three of the five. Examination of screening profiles of the five inhibitors toward the NCI’s tumor cell lines revealed that they were cytotoxic to the leukemia subpanel (particularly K562 cells). Oxygen consumption experiments with permeabilized K562 cells revealed that the five most active compounds inhibited complex I activity in these cells in the same rank order and similar potency as determined with bovine heart SMP. Our findings thus fortify the appeal of mitochondrial Complex I as a possible anti-cancer molecular target and provide a data mining strategy for selecting candidate inhibitors for further testing. PMID:17109823

  17. Spatial Abilities in an Elective Course of Applied Anatomy After a Problem-Based Learning Curriculum

    NSDL National Science Digital Library

    Jean Langlois (Centre hospitalier Universitaire de Sherbrooke Emergency Medicine)

    2009-05-01

    This article describes a prospective study examining the effect of an elective applied anatomy course for medical residents on spatial anatomy abilities. The primary focus of the article is the level of interest residents have in a spatial anatomy course after completing a problem based learning curriculum. Outcomes discussed are the residents determination for additional anatomy instruction upon conclusion of a PBL course and reasons for general interest in selecting a spatial anatomy course.

  18. Sensory organs on the body parts of the bed-bug Cimex hemipterus fabricius (Hemiptera : Cimicidae) and the anatomy of its central nervous system

    Microsoft Academic Search

    R. Naresh Singh; Kusum Singh; Shri Prakash; M. J. Mendki; K. M. Rao

    1996-01-01

    Anatomy of the sensory organs on the prominent body parts of the adult bed-bug Cimex hemipterus (Hemiptera: Cimicidae) and its central nervous system (CNS) was studied by light, transmission, or scanning electron microscopy. The distal tips of antenna and rostrum were found to have rich complements of sensilla. The antenna has both olfactory and gustatory sensilla. Olfactory sensilla project to

  19. [Normal abdominal ultrasound anatomy. Examination procedure].

    PubMed

    Salcedo Joven, I; Segura Grau, A; Rodríguez Lorenzo, A; Segura Cabral, J M

    2014-01-01

    To carry out an abdominal ultrasound examination with the highest degree of accuracy and thoroughness, it is essential to have a good knowledge of the anatomy and the normal measurements of the different organs. In this way, we can determine their normal condition and identify the pathology and its location more easily. It is very important to adopt a correct examination procedure, systematically sweeping the scan in the same direction and not leaving any organ unexamined. We suggest a procedure consisting of longitudinal, cross-sectional and oblique scans to view all the abdominal organs, starting the examination in the epigastric region, scanning first the right upper quadrant, then the left upper quadrant, both iliac fossa, and lastly the hypogastric region. PMID:24746380

  20. Kienböck's disease. I. Anatomy and Etiology.

    PubMed

    Fredericks, T K; Fernandez, J E; Pirela-Cruz, M A

    1997-01-01

    Cumulative trauma disorders (CTD) pose a major industrial problem in terms of increased medical costs, lost productivity and degraded worker health and safety. From an anatomical view, CTD's are classified into three major categories: tendon disorders, neurovascular disorders and nerve disorders. Up until recently these categories seemed to cover CTD of the upper extremity, however, Kienböck's disease, a typically less common disease and one that does not fit into the established CTD categories, has been observed to exhibit CTD characteristics and does appear in the manufacturing environment. The most common types of employment observed to exhibit individuals with this disease are carpentry, jobs involving the use of pneumatic tools (wrench), spot welders, sheet metal work, farmers and factory workers. The present article makes a critical examination of the relevant anatomy and etiologic aspects of this disease. PMID:9187042

  1. Surgical anatomy of tetralogy of Fallot.

    PubMed

    Anderson, R H; Allwork, S P; Ho, S Y; Lenox, C C; Zuberbuhler, J R

    1981-06-01

    On the basis of previous experience, we have analyzed the anatomy of a series of 53 hearts catalogued as having tetralogy of Fallot in the museum of the Children's Hospital of Pittsburgh. All hearts had a ventricular septal defect, aortic overriding, infundibular pulmonary obstruction, and right ventricular hypertrophy. None of the hearts had been operated upon during life. We paid particular attention to features of surgical importance. Thus the ventricular septal defect was found to be of variable form. It was perimembranous in 42 hearts. In 11 hearts it had entirely muscular rims and in the remaining heart it was roofed by the conjoined aortic and pulmonary valve rings (subarterial). From our previous histologic experience, it was evident that this varying morphology significantly affected the surgical anatomy of the atrioventricular conduction tissues. We endeavored to display this disposition as might be viewed by the surgeon. The degree of aortic override was variable, the aortic valve being connected by 15% to 95% to the right ventricle. In 17 hearts more than half the aortic valve was attached to right ventricular musculature. The nature of the infundibular obstruction also varied markedly. In all cases (except the one with absent infundibular septum) the infundibular septum was deviated in cephalad and anterior direction so as to produce obstruction. In the majority of hearts further anatomic structures also contributed to the obstruction. In some hearts there was hypertrophy of the infundibular septum, particularly at its junction with the trabecular septum. In others there was hypertrophy of the trabecula septomarginalis, and in many hearts there was hypertrophy of additional anterior infundibular trabeculations. The pulmonary valve was the narrowest point of the outflow tract in only six hearts, but in many of the others, it was abnormal. The results emphasize that while hearts may exhibit the classical features of tetralogy of Fallot, there is usually considerable individual variation in each of these features which is of major surgical significance. PMID:7194951

  2. Renal anatomy in sparrows from different environments.

    PubMed

    Casotti, G; Braun, E J

    2000-03-01

    The renal anatomy of three species of sparrows, two from mesic areas, the House Sparrow (Passer domesticus) and Song Sparrow (Melospiza melodia), and one salt marsh species, the Savannah Sparrow (Passerculus sandwichensis) was examined. Electron microscopy was used to describe the ultrastructure of the nephron. In addition, stereology was used to quantify the volumes of cortex, medulla, and major vasculature of the kidneys, and the volumes and surface areas occupied by individual nephron components. There appeared to be no differences in the ultrastructural anatomy of the nephrons among the sparrows. Proximal tubules contained both narrow and wide intercellular spaces filled with interdigitations of the basolateral membrane. The thin limbs of Henle contained very wide intercellular spaces which were absent in the thick limbs of Henle. The distal tubule cells contained short, apical microvilli and infoldings of the basolateral membrane. In cross section, the medullary cones of all birds display an outer ring of thick limbs of Henle which surround an inner ring of collecting ducts, which in turn surround a central core of thin limbs of Henle. The Savannah Sparrow has a significantly higher volume of medulla compared to the two more mesic species. Within the cortex, the Savannah Sparrow also has a significantly higher volume of proximal tubules but a significantly lower volume of distal tubules than the other species. Within the medulla, the Savannah Sparrow has a significantly higher volume and surface area of capillaries, and a significantly higher surface area of thick limbs of Henle and collecting ducts than the mesic species. These data suggest that the salt marsh Savannah Sparrow has the renal morphology necessary to produce a more highly concentrated urine than the mesic zone species. PMID:10681473

  3. Evaluation of the effectiveness of a radiographic anatomy tutorial 

    E-print Network

    Lewis, Cheri MacFarlane

    2001-01-01

    . Both users and nonusers took a test containing 7 questions relevant to radiographic anatomy. Users gave more correct responses than nonusers on 4 questions. A chi-square analysis demonstrated a statistically significant difference on 2 questions ([p]<0...

  4. Teaching of clinical anatomy in rheumatology: a review of methodologies.

    PubMed

    Torralba, Karina D; Villaseñor-Ovies, Pablo; Evelyn, Christine M; Koolaee, R Michelle; Kalish, Robert A

    2015-07-01

    Clinical anatomy may be defined as anatomy that is applied to the care of the patient. It is the foundation of a well-informed physical examination that is so important in rheumatologic practice. Unfortunately, there is both documented and observed evidence of a significant deficiency in the teaching and performance of a competent musculoskeletal examination at multiple levels of medical education including in rheumatology trainees. At the Annual Meeting of the American College of Rheumatology in Boston, MA, that took place in November 2014, a Clinical Anatomy Study Group met to share techniques of teaching clinical anatomy to rheumatology fellows, residents, and students. Techniques that were reviewed included traditional anatomic diagrams, hands-on cross-examination, cadaver study, and musculoskeletal ultrasound. The proceedings of the Study Group section are described in this review. PMID:26037454

  5. Spatial Motion Constraints Using Virtual Fixtures Generated by Anatomy

    Microsoft Academic Search

    Ming Li; Masaru Ishii; Russell H. Taylor

    2007-01-01

    This paper describes a spatial motion constraints generation approach for human-machine collaborative surgi- cal assistant system from registered CT models. We extend constrained optimization formulation incorporating task goals, anatomy-based constraints, \\

  6. How the Musculoskeletal System Works: Integrating Anatomy and Function

    E-print Network

    Cooper, Robin L.

    How the Musculoskeletal System Works: Integrating Anatomy and Function Biomechanics laboratory task. The operation of the musculoskeletal system can be understood using the principles of lever; the #12; mechanical #12; principles #12; by #12; which #12; the #12; musculoskeletal

  7. How-To-Do-It: Pig Foot Anatomy.

    ERIC Educational Resources Information Center

    Rowe, Paula M.

    1988-01-01

    Described is an activity used to introduce the anatomy of the skeletal and muscular systems. A teacher conducted, video enhanced demonstration and a student activity are discussed. Included is a sample student laboratory paper. (CW)

  8. Evaluation of anatomy comic strips for further production and applications.

    PubMed

    Shin, Dong Sun; Kim, Dae Hyun; Park, Jin Seo; Jang, Hae Gwon; Chung, Min Suk

    2013-09-01

    The corresponding author of the study has been sketching comic strips to explain anatomy in a humorous manner. All the anatomy comic strips, including those in Korean (650 episodes) and English (451 episodes), can be viewed on the homepage (http://anatomy.co.kr). Such comic strips were created with the aim of assisting medical students. However, their impact was unknown, and therefore, we surveyed the students' responses. We noted that anatomy grades were better in the students who read the comic strips. The comics helped the trainees chat with individuals with and without a medical background. The authors also considered comments on the problems with the comic strips and attempted to find solutions. The episodes are being currently used and further produced for educational purposes. To support this effort, the readers' valuable opinions will be continuously collected and assessed. PMID:24179697

  9. Evaluation of anatomy comic strips for further production and applications

    PubMed Central

    Shin, Dong Sun; Kim, Dae Hyun; Park, Jin Seo; Jang, Hae Gwon

    2013-01-01

    The corresponding author of the study has been sketching comic strips to explain anatomy in a humorous manner. All the anatomy comic strips, including those in Korean (650 episodes) and English (451 episodes), can be viewed on the homepage (http://anatomy.co.kr). Such comic strips were created with the aim of assisting medical students. However, their impact was unknown, and therefore, we surveyed the students' responses. We noted that anatomy grades were better in the students who read the comic strips. The comics helped the trainees chat with individuals with and without a medical background. The authors also considered comments on the problems with the comic strips and attempted to find solutions. The episodes are being currently used and further produced for educational purposes. To support this effort, the readers' valuable opinions will be continuously collected and assessed. PMID:24179697

  10. Constructivist Learning of Anatomy: Gaining Knowledge by Creating Anatomical Casts

    NSDL National Science Digital Library

    Heidi L. Lujan (Wayne State Univ Sch Med Dept of Physiology)

    2011-03-01

    This article describes a method to promote inquiry based learning in the anatomy curriculum. The article describes a method requiring students to build casts of the bronchial tree and coronary arteries while faculty asked leading questions related to the material.

  11. mRNA and microRNA expression profiles of radioresistant NCI?H520 non?small cell lung cancer cells.

    PubMed

    Guo, Wei; Xie, Li; Zhao, Long; Zhao, Yuehuan

    2015-08-01

    To elucidate the mechanism of radioresistance in non?small cell lung cancer (NSCLC) cells and to identify key molecules conferring radioresistance, the radioresistant subclone NCI?H520/R, derived from the NCI?H520 NSCLC cell line, was established with eight rounds of sublethal irradiation. The radioresistant features were subsequently assessed using a clonogenic assay, analysis of apoptosis and an MTT assay, the gene expression levels were examined using an Agilent Whole Human Genome 4x44 k Oligo microarray and Agilent Human miRCURY™ LNA array, and confirmed by reverse transcription?quantitative polymerase chain reaction. Pathway analysis and Gene Ontology (GO) analysis were performed to determine the biological functions of the subset of differentially expressed genes. miRNA?mRNA correlation analysis between the expression levels of each miRNA and all its predicted target genes was performed to further understand the radioresistance in the NCI?H520 cells. Following eight rounds of sublethal irradiation, a total of 2,862 mRNAs were significantly differentially expressed in the NCI?H520/R cells, including 893 upregulated genes and 1,969 downregulated genes. A total of 162 upregulated miRNAs and 274 downregulated miRNAs were significantly deregulated in the NCI?H520/R cells. Multiple core regulatory processes and signaling pathways were identified as being of likely relevance to radioresistance in NCI?H520/R cells, including the mitogen?activated protein kinase signaling pathway and neurotrophin signaling pathway. The expression of genes associated with radioresistance reflects the complex biological processes involved in clinical cancer cell eradication and requires further investigation for future enhancement of therapy. PMID:25873351

  12. mRNA and microRNA expression profiles of radioresistant NCI-H520 non-small cell lung cancer cells

    PubMed Central

    GUO, WEI; XIE, LI; ZHAO, LONG; ZHAO, YUEHUAN

    2015-01-01

    To elucidate the mechanism of radioresistance in non-small cell lung cancer (NSCLC) cells and to identify key molecules conferring radioresistance, the radioresistant subclone NCI-H520/R, derived from the NCI-H520 NSCLC cell line, was established with eight rounds of sublethal irradiation. The radioresistant features were subsequently assessed using a clonogenic assay, analysis of apoptosis and an MTT assay, the gene expression levels were examined using an Agilent Whole Human Genome 4×44 k Oligo microarray and Agilent Human miRCURY™ LNA array, and confirmed by reverse transcription-quantitative polymerase chain reaction. Pathway analysis and Gene Ontology (GO) analysis were performed to determine the biological functions of the subset of differentially expressed genes. miRNA-mRNA correlation analysis between the expression levels of each miRNA and all its predicted target genes was performed to further understand the radioresistance in the NCI-H520 cells. Following eight rounds of sublethal irradiation, a total of 2,862 mRNAs were significantly differentially expressed in the NCI-H520/R cells, including 893 upregulated genes and 1,969 downregulated genes. A total of 162 upregulated miRNAs and 274 downregulated miRNAs were significantly deregulated in the NCI-H520/R cells. Multiple core regulatory processes and signaling pathways were identified as being of likely relevance to radioresistance in NCI-H520/R cells, including the mitogen-activated protein kinase signaling pathway and neurotrophin signaling pathway. The expression of genes associated with radioresistance reflects the complex biological processes involved in clinical cancer cell eradication and requires further investigation for future enhancement of therapy. PMID:25873351

  13. TeleImmersion: Preferred Infrastructure for Anatomy Instruction

    Microsoft Academic Search

    Jonathan C. Silverstein; Jesse M. Ehrenfeld; Darin A. Croft; Fred W. Dech; Stephen Small; Sandy Cook

    2006-01-01

    UNDERSTANDING SPATIAL RELATIONSHIPS among anatomic structures is an essential skill for physicians. Traditional medical education—using\\u000a books, lectures, physical models, and cadavers—may be insufficient for teaching complex anatomical relationships. This study\\u000a was designed to measure whether teaching complex anatomy to medical students using immersive virtual reality is an improvement\\u000a over traditional methods. Using a networked immersive virtual reality system, anatomy-teaching assistants

  14. Evolution of the paranasal sinuses' anatomy through the ages.

    PubMed

    Mavrodi, Alexandra; Paraskevas, George

    2013-12-01

    Previously, anatomists considered paranasal sinuses as a mysterious region of the human skull. Historically, paranasal sinuses were first identified by ancient Egyptians and later, by Greek physicians. After a long period of no remarkable improvement in the understanding of anatomy during the Middle Ages, anatomists of the Renaissance period-Leonardo da Vinci and Vesalius-made their own contribution. Nathaniel Highmore's name is also associated with the anatomy of paranasal sinuses as he was first to describe the maxillary sinus. PMID:24386595

  15. The use of computers to teach human anatomy and physiology to allied health and nursing students

    NASA Astrophysics Data System (ADS)

    Bergeron, Valerie J.

    Educational institutions are under tremendous pressure to adopt the newest technologies in order to prepare their students to meet the challenges of the twenty-first century. For the last twenty years huge amounts of money have been spent on computers, printers, software, multimedia projection equipment, and so forth. A reasonable question is, "Has it worked?" Has this infusion of resources, financial as well as human, resulted in improved learning? Are the students meeting the intended learning goals? Any attempt to develop answers to these questions should include examining the intended goals and exploring the effects of the changes on students and faculty. This project investigated the impact of a specific application of a computer program in a community college setting on students' attitudes and understanding of human anatomy and physiology. In this investigation two sites of the same community college with seemingly similar students populations, seven miles apart, used different laboratory activities to teach human anatomy and physiology. At one site nursing students were taught using traditional dissections and laboratory activities; at the other site two of the dissections, specifically cat and sheep pluck, were replaced with the A.D.A.M.RTM (Animated Dissection of Anatomy for Medicine) computer program. Analysis of the attitude data indicated that students at both sites were extremely positive about their laboratory experiences. Analysis of the content data indicated a statistically significant difference in performance between the two sites in two of the eight content areas that were studied. For both topics the students using the computer program scored higher. A detailed analysis of the surveys, interviews with faculty and students, examination of laboratory materials, and observations of laboratory facilities in both sites, and cost-benefit analysis led to the development of seven recommendations. The recommendations call for action at the level of the institution requiring investment in additional resources, and at the level of the faculty requiring a commitment to exploration and reflective practice.

  16. Effects of training experienced teachers in the use of the one-minute preceptor technique in the gross anatomy laboratory.

    PubMed

    Chan, Lap Ki; Sharma, Neel

    2014-01-01

    The one-minute preceptor (OMP) is a time-efficient, learner-centered teaching method used in a busy ambulatory care setting. This project evaluated the effects of training experienced anatomy teachers in the use of the OMP in the gross anatomy laboratory on students' perceived learning. Second-year medical students from a five-year, undergraduate-entry, system- and problem-based medical program were divided randomly into two groups of 76 students each. The groups took part in the same gross anatomy laboratory session on different dates, supervised by the same two teachers (both with over 25 years of teaching experience). The teachers attended a workshop on the use of the OMP between the two sessions. Students were given a questionnaire at the end of the two sessions to indicate their agreements to statements regarding their learning experiences. Semistructured interviews were conducted with the two teachers after the second session. Results showed that training experienced anatomy teachers in the use of the OMP did not result in improvement of student learning perception in the gross anatomy laboratory. The experienced teachers have developed their own approaches with elements similar to those in the OMP: being learner centered and adaptable to individual student's needs, providing feedback, and enhancing teacher immediacy. They do not have an explicit structure such as the OMP, and are thus flexible and adaptive. Confining the teachers' teaching behaviors to the OMP structure could limit their performance. Although there are theoretical advantages for novice teachers in adopting the OMP technique, these advantages still need to be supported by further studies. PMID:23864286

  17. Project Gutenberg

    NSDL National Science Digital Library

    Back in 1971, Michael Hart was given an operator's account with $100 million of computer time in it, courtesy of the operators of the Xerox Sigma V mainframe at the Materials Research Lab at the University of Illinois. He decided to give something back by creating electronic versions of different important documents, such as the Declaration of Independence. Thus, Project Gutenberg was born, and today this online archive contains 32,000 books which can be read online or on a portable device. From the homepage, visitors can perform a simple search, or use the "Bookshelves by topic" or "Top downloads" sections to focus in for some new reading material. Some of the most popular works include "Dracula", "Ulysses", and "The Count of Monte Cristo". Of course, visitors should also check out more obscure gems, like "The Anatomy of Melancholy", by scholar and Oxford fellow Robert Burton.

  18. NCI-H292 as an alternative cell line for the isolation and propagation of the human paramyxoviruses.

    PubMed

    Castells, E; George, V G; Hierholzer, J C

    1990-01-01

    Primary rhesus monkey kidney (MK) cells have long been the cells of choice for isolation and propagation of the human paramyxoviruses (parainfluenza 1, 2, 3, 4A, 4B, and mumps). However, problems with the supply and cost of MK cells and the presence of endogenous viruses, including herpes B virus and SV-5, necessitated a search for an alternative cell line. Continuous cell cultures of human origin (L132, A-549, HuT-292, HEK, G-293, G-401, A-498, A-704, CAKI-1, RD) and simian origin (LLC-MK2, BSC-1, MA-104, Vero) were evaluated for their capacity to support the growth of the human paramyxoviruses, as followed by cytopathic effect, hemadsorption, hemagglutination, and EIA. NCI-H292 (HuT-292) human lung mucoepidermoid carcinoma cells (ATCC # CRL-1848) proved to be the most sensitive line for cultivating all serotypes and strains of the paramyxoviruses. These cells were also shown to be a suitable substitute for MK in primary isolation of paramyxoviruses from clinical specimens. RPMI-1640 with 1.5 micrograms/ml trypsin was the preferred maintenance medium; alternatively, Eagle's MEM supplemented with 1.5 micrograms/ml trypsin and 0.1% ITS was satisfactory. NCI-H292 cells are a continuous line with excellent growth characteristics, although the genetic polyploidy of the cells may limit the number of passages of usable cells. PMID:2260924

  19. The clinical anatomy of the sinutubular junction.

    PubMed

    Loukas, Marios; Wartmann, Christopher T; Tubbs, R Shane; Apaydin, Nihal; Louis, Robert G; Easter, Laurie; Black, Brandie; Jordan, Robert

    2009-04-01

    Specific sites of atherosclerotic processes due to hemodynamic changes and resultant stress, including how these normal anatomical structures become problematic in certain individuals, have yet to be acknowledged. One of these areas of the cardiovascular system occurs at the sinutubular junction (SJ), causing altercation in an otherwise normal flow status. The anatomy of the SJ was examined in 100 adult human hearts during the gross anatomy course at St George's University, during the years 2006-2007. All hearts were examined in situ, using a General Electric model 3200S ultrasound machine with a 5 MHz linear probe. The aforementioned cadavers were also examined using a Stryker laparoscopic unit. Serial transverse histological sections were made through the SJ perpendicular to its axis, and stained with eosin-hematoxylin, van Gieson, Masson trichrome, and Orcein methods. In addition, an immunohistochemical analysis was performed for the detection of positive smooth muscle cells stained areas. During gross and endoscopic examination we were able to identify the SJ in all adult heart specimens. Neonatal and fetal hearts did not exhibit any gross evident SJ; however, a SJ was evident histologically. Ultrasonographically we were able to identify the SJ in all adult heart specimens examined, and a sinutubular ridge in 62%. A significant association was present between the thickness of the ridge and the age of the specimens. The SJ was found to exhibit atherosclerotic changes and plaque formation in an age-related manner. In older subjects, the SJ was marked with local calcification and hemorrhages. In contrast, the SJ of neonatal hearts appeared to have intimal thickening with focal fragmentation and absent or duplicate internal elastic lamina. Intuitively speaking, the presence of a sinutubular ridge, an inevitable fate in humans based on the results of this study, provides an irreversible atherosclerotic process as there is no evidence that the promoting ridge regresses. This is an alarming situation in those individuals who will eventually develop cardiovascular risk factors, whether through inevitable genetic manifestations or by means of exogenous environmental causes. PMID:19224331

  20. Anatomy and efficiency of urban multimodal mobility.

    PubMed

    Gallotti, Riccardo; Barthelemy, Marc

    2014-01-01

    The growth of transportation networks and their increasing interconnections, although positive, has the downside effect of an increasing complexity which make them difficult to use, to assess, and limits their efficiency. On average in the UK, 23% of travel time is lost in connections for trips with more than one mode, and the lack of synchronization decreases very slowly with population size. This lack of synchronization between modes induces differences between the theoretical quickest trip and the 'time-respecting' path, which takes into account waiting times at interconnection nodes. We analyse here the statistics of these paths on the multilayer, temporal network of the entire, multimodal british public transportation system. We propose a statistical decomposition - the 'anatomy' - of trips in urban areas, in terms of riding, waiting and walking times, and which shows how the temporal structure of trips varies with distance and allows us to compare different cities. Weaknesses in systems can be either insufficient transportation speed or service frequency, but the key parameter controlling their global efficiency is the total number of stop events per hour for all modes. This analysis suggests the need for better optimization strategies, adapted to short, long unimodal or multimodal trips. PMID:25371238

  1. Comprehensive combined visualization of anatomy and hemodynamics

    NASA Astrophysics Data System (ADS)

    Kose, Ursula; Visser, Kees P.; Tryon, Cathy L.; Breeuwer, Marcel

    2005-04-01

    In recent years, the assessment of patient-specific hemodynamic information of the cardiovascular system has become an important issue. It is believed that this information will improve the diagnosis and treatment of cardiovascular diseases. Realistic patient geometries and flow velocities acquired from image data can nowadays be used as input for computational fluid dynamics (CFD) simulations of the blood flow through the cardiovascular system. Results obtained from these simulations have to be comprehensively visualized so that the physician can understand them and draw diagnostic and/or therapeutic conclusions. The aim of the research reported in this paper is to provide methods for the combined comprehensive visualization of the anatomical information segmented from image data with the hemodynamic information acquired by CFD simulations based on these image data. Several methods are known for the visualization of the blood flow velocity, e.g. flow streamlines, particle traces or simple cut planes through the vessel with a color-coded overlay of the flow velocity. To make these flow visualizations more understandable for the physician, we have developed methods to generate combined visualizations of the simulated blood flow velocity and the patient"s anatomy segmented from the image data. First results of these methods show that the perception of CFD simulation results of blood flow is much better when it is combined with anatomical information of surrounding structures. Physicians reacted very enthusiastically during presentations of results of our new visualization methods. Results will be demonstrated at the conference.

  2. Comparative and Developmental Anatomy of Cardiac Lymphatics

    PubMed Central

    Ratajska, A.; Gula, G.; Flaht-Zabost, A.; Czarnowska, E.; Ciszek, B.; Jankowska-Steifer, E.; Niderla-Bielinska, J.; Radomska-Lesniewska, D.

    2014-01-01

    The role of the cardiac lymphatic system has been recently appreciated since lymphatic disturbances take part in various heart pathologies. This review presents the current knowledge about normal anatomy and structure of lymphatics and their prenatal development for a better understanding of the proper functioning of this system in relation to coronary circulation. Lymphatics of the heart consist of terminal capillaries of various diameters, capillary plexuses that drain continuously subendocardial, myocardial, and subepicardial areas, and draining (collecting) vessels that lead the lymph out of the heart. There are interspecies differences in the distribution of lymphatic capillaries, especially near the valves, as well as differences in the routes and number of draining vessels. In some species, subendocardial areas contain fewer lymphatic capillaries as compared to subepicardial parts of the heart. In all species there is at least one collector vessel draining lymph from the subepicardial plexuses and running along the anterior interventricular septum under the left auricle and further along the pulmonary trunk outside the heart and terminating in the right venous angle. The second collector assumes a different route in various species. In most mammalian species the collectors run along major branches of coronary arteries, have valves and a discontinuous layer of smooth muscle cells. PMID:24592145

  3. Content-Specific Auditing of a Large Scale Anatomy Ontology

    PubMed Central

    Kalet, Ira J.; Mejino, Jose L. V.; Wang, Vania; Whipple, Mark; Brinkley, James F.

    2009-01-01

    Biomedical ontologies are envisioned to be useable in a range of research and clinical applications. The requirements for such uses include formal consistency, adequacy of coverage, and possibly other domain specific constraints. In this report we describe a case study that illustrates how application specific requirements may be used to identify modeling problems as well as data entry errors in ontology building and evolution. We have begun a project to use the UW Foundational Model of Anatomy (FMA) in a clinical application in radiation therapy planning. This application focuses mainly (but not exclusively) on the representation of the lymphatic system in the FMA, in order to predict the spread of tumor cells to regional metastatic sites. This application requires that the downstream relations associated with lymphatic system components must only be to other lymphatic chains or vessels, must be at the appropriate level of granularity, and that every path through the lymphatic system must terminate at one of the two well known trunks of the lymphatic system. It is possible through a programmable query interface to the FMA to write small programs that systematically audit the FMA for compliance with these constraints. We report on the design of some of these programs, and the results we obtained by applying them to the lymphatic system. The algorithms and approach are generalizable to other network organ systems in the FMA such as arteries and veins. In addition to illustrating exact constraint checking methods, this work illustrates how the details of an application may reflect back a requirement to revise the design of the ontology itself. PMID:19248842

  4. NIH Announces Two Integral Components of The Cancer Genome Atlas Pilot Project | Office of Cancer Genomics

    Cancer.gov

    The National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI), both parts of the National Institutes of Health (NIH), today announced another two of the components of The Cancer Genome Atlas (TCGA) Pilot Project, a three-year, $100 million collaboration to test the feasibility of using large-scale genome analysis technologies to identify important genetic changes involved in cancer. Lung, brain (glioblastoma), and ovarian cancers have been chosen as the tumors for study by TCGA Pilot Project.

  5. NCI60 Cancer Cell Line Panel Data and RNAi Analysis Help Identify EAF2 as a Modulator of Simvastatin and Lovastatin Response in HCT116 Cells

    Microsoft Academic Search

    Sevtap Savas; David O. Azorsa; Hamdi Jarjanazi; Irada Ibrahim-Zada; Irma M. Gonzales; Shilpi Arora; Meredith C. Henderson; Yun Hee Choi; Laurent Briollais; Hilmi Ozcelik; Sukru Tuzmen; Eric Bernhard

    2011-01-01

    Simvastatin and lovastatin are statins traditionally used for lowering serum cholesterol levels. However, there exists evidence indicating their potential chemotherapeutic characteristics in cancer. In this study, we used bioinformatic analysis of publicly available data in order to systematically identify the genes involved in resistance to cytotoxic effects of these two drugs in the NCI60 cell line panel. We used the

  6. Chemical Data Mining of the NCI Human Tumor Cell Line Database Huijun Wang, Jonathan Klinginsmith, Xiao Dong, Adam C. Lee, Rajarshi Guha, Yuqing Wu,

    E-print Network

    Wu, Yuqing Melanie

    Chemical Data Mining of the NCI Human Tumor Cell Line Database Huijun Wang, Jonathan Klinginsmith Tenth Street, Bloomington, Indiana 47408, and College of Pharmacy, University of Michigan, 428 Church Human Tumor cell line data set is a publicly available database that contains cellular assay screening

  7. NCI’s Development of Baseline Cancer and Radiation-Related Illness Rates Relating to Nuclear Weapons Testing in the Marshall Islands - July 19, 2005

    Cancer.gov

    Chairman Domenici and Members of the Committee on Energy and Natural Resources, thank you for the opportunity to testify on behalf of the National Cancer Institute (NCI) of the National Institutes of Health, an agency of the U.S. Department of Health and Human Services.

  8. NCI’s Development of Baseline Cancer and Radiation-Related Illness Rates Relating to Nuclear Weapons Testing in the Marshall Islands - May 25, 2005

    Cancer.gov

    Chairman Pombo and Chairman Leach, Members of the Committee on Resources and the International Relations Subcommittee on Asia and the Pacific, thank you for the opportunity to testify on behalf of the National Cancer Institute (NCI) of the National Institutes of Health, an agency of the U.S. Department of Health and Human Services.

  9. Demethoxycurcumin-induced DNA Damage Decreases DNA Repair-associated Protein Expression Levels in NCI-H460 Human Lung Cancer Cells.

    PubMed

    Ko, Yang-Ching; Lien, Jin-Cherng; Liu, Hsin-Chung; Hsu, Shu-Chun; Lin, Hui-Yi; Chueh, Fu-Shin; Ji, Bin-Chuan; Yang, Mei-Due; Hsu, Wu-Huei; Chung, Jing-Gung

    2015-05-01

    Demethoxycurcumin (DMC) is a key component of Chinese medicine (Turmeric) and has been proven effective in killing various cancer cells. Its role in inducing cytotoxic effects in many cancer cells has been reported, but its role regarding DNA damage on lung cancer cells has not been studied in detail. In the present study, we demonstrated DMC-induced DNA damage and condensation in NCI-H460 cells by using the Comet assay and DAPI staining examinations, respectively. Western blotting indicated that DMC suppressed the protein levels associated with DNA damage and repair, such as 14-3-3? (an important checkpoint keeper of DNA damage response), DNA repair proteins breast cancer 1, early onset (BRCA1), O6-methylguanine-DNA methyltransferase (MGMT), mediator of DNA damage checkpoint 1 (MDC1), and p53 (tumor suppressor protein). DMC activated phosphorylated p53 and p-H2A.X (phospho Ser140) in NCI-H460 cells. Furthermore, we used confocal laser systems microscopy to examine the protein translocation. The results showed that DMC promotes the translocation of p-p53 and p-H2A.X from the cytosol to the nuclei in NCI-H460 cells. Taken together, DMC induced DNA damage and affected DNA repair proteins in NCI-H460 cells in vitro. PMID:25964547

  10. Kliniker-Vorlesungen in der Anatomie Wintersemester 2012/2013 Hrsaal V 1 Vorklinik 9:15-10:00

    E-print Network

    Groppe, Jinghua

    Kliniker-Vorlesungen in der Anatomie Wintersemester 2012/2013 ­ Hörsaal V 1 Vorklinik ­ 9 Schädigungsmuster Differentialdiagnostik Fallbeispiele Organisation: Institut für Anatomie Universität zu Lübeck

  11. Establishment and biological characteristics of acquired gefitinib resistance in cell line NCI-H1975/gefinitib-resistant with epidermal growth factor receptor T790M mutation.

    PubMed

    Zhao, Bao-Xia; Wang, Jing; Song, Bo; Wei, Hong; Lv, Wei-Peng; Tian, Li-Min; Li, Mei; Lv, Shen

    2015-04-01

    Non?small cell lung cancer (NSCLC) cells harboring mutations in the epidermal growth factor receptor (EGFR) gene initially respond well to EGFR tyrosine kinase inhibitors (TKI), including gefitinib. However the tumor cells will invariably develop acquired resistance to the drug. The EGFR T790M mutation is generally considered to be the molecular genetic basis of acquired TKI resistance. The present study aimed to explore how the T790M mutation induces tumor cells to escape inhibition by TKI treatment. An acquired gefitinib?resistant cell line (NCI?H1975/GR) was generated from the NCI?H1975 human NSCLC cell line, which harbors the sensitive L858R and resistant T790M mutations of EGFR. The resistant cell line was established by exposing the cells intermittently to increasing concentrations of gefitinib. The mechanisms by which NSCLC acquires resistance to TKIs based on the T790M mutation, were investigated by detecting the protein expression levels of the EGFR/Kirsten rat sarcoma viral oncogene homolog (KRAS)/v?Raf murine sarcoma viral oncogene homolog B (BRAF) transduction pathway, and epithelial?mesenchymal transition (EMT) with immunocytochemistry. The resistance of the NCI?H1975/GR cells to gefitinib was 2.009?fold, as compared with the parent cells; however, the protein expression levels of EGFR, KRAS and BRAF were lower in the resistant cells. Some mesenchymal morphology was observed in the NCI?H1975/GR cells, alongside a decreasing E?cadherin expression and increasing vimentin expression. These results suggest that the reactivation of the EGFR/KRAS/BRAF transduction pathway was not detected in the NCI?H1975/GR cells. EMT may have an important role in the development of acquired resistance to EGFR?TKIs in NSCLC cells with sensitivity and resistance mutations. PMID:25483995

  12. Spatial Abilities of Expert Clinical Anatomists: Comparison of Abilities Between Novices, Intermediates, and Experts in Anatomy

    NSDL National Science Digital Library

    Ruth Fernandez (University of Southampton Centre for Learning Anatomical Sciences)

    2011-01-17

    This article describes a study with two aims: To determine if spatial ability is a learned or inherent facet in learning anatomy and to ascertain if there is any difference in spatial ability between experts and novices in anatomy.

  13. Muscular Anatomy of the Podocoryna carnea Hydrorhiza

    PubMed Central

    Buss, Leo W.; Anderson, Christopher; Bolton, Edward W.

    2013-01-01

    The muscular anatomy of the athecate hydroid Podocoryna carnea hydrorhiza is elucidated. The polyp-stolon junction is characterized by an opening, here called the chloe, in the otherwise continuous hydrorhizal perisarc. The chloe is elliptical when the polyp first arises, but takes on a more complex outline as multiple stolons anastomose to communicate with that polyp. Surrounding the polyp base are spots, here called anchors, which autofluoresce at the same wavelengths as perisarc and which, like perisarc, contain chitin as assessed by Calcofluor White, Congo Red and wheat germ agglutinin staining. Anchors remain after living tissues are digested using KOH. Collagen IV staining indicates that the mesoglea is pegged to the anchors and rhodamine phallodin staining detects cytoskeletal F-actin fibers of the basal epidermis surrounding the anchors. Longitudinal muscle fibers of the polyp broaden at the polyp base and are inserted into the mesoglea of the underlying stolon, but were neither observed to extend along the stolonal axis nor to attach to the anchors. Circular muscular fibers of the polyp extend into stolons as a dense collection of strands running along the proximal-distal axis of the stolon. These gastrodermal axial muscular fibers extend to the stolon tip. Epidermal cells at the stolon tip and the polyp bud display a regular apical latticework of F-actin staining. A similar meshwork of F-actin staining was found in the extreme basal epidermis of all stolons. Immunohistochemical staining for tubulin revealed nerves at stolon tips, but at no other hydrorhizal locations. These studies bear on the mechanisms by which the stolon tip and polyp bud pulsate, the manner in which the stolon lumen closes, and on the developmental origin of the basal epidermis of the hydrorhiza. PMID:23967288

  14. Automatic anatomy recognition via fuzzy object models

    NASA Astrophysics Data System (ADS)

    Udupa, Jayaram K.; Odhner, Dewey; Falcão, Alexandre X.; Ciesielski, Krzysztof C.; Miranda, Paulo A. V.; Matsumoto, Monica; Grevera, George J.; Saboury, Babak; Torigian, Drew A.

    2012-02-01

    To make Quantitative Radiology a reality in routine radiological practice, computerized automatic anatomy recognition (AAR) during radiological image reading becomes essential. As part of this larger goal, last year at this conference we presented a fuzzy strategy for building body-wide group-wise anatomic models. In the present paper, we describe the further advances made in fuzzy modeling and the algorithms and results achieved for AAR by using the fuzzy models. The proposed AAR approach consists of three distinct steps: (a) Building fuzzy object models (FOMs) for each population group G. (b) By using the FOMs to recognize the individual objects in any given patient image I under group G. (c) To delineate the recognized objects in I. This paper will focus mostly on (b). FOMs are built hierarchically, the smaller sub-objects forming the offspring of larger parent objects. The hierarchical pose relationships from the parent to offspring are codified in the FOMs. Several approaches are being explored currently, grouped under two strategies, both being hierarchical: (ra1) those using search strategies; (ra2) those strategizing a one-shot approach by which the model pose is directly estimated without searching. Based on 32 patient CT data sets each from the thorax and abdomen and 25 objects modeled, our analysis indicates that objects do not all scale uniformly with patient size. Even the simplest among the (ra2) strategies of recognizing the root object and then placing all other descendants as per the learned parent-to-offspring pose relationship bring the models on an average within about 18 mm of the true locations.

  15. Training researchers in cancer prevention and control: a description and evaluation of NCI's Cancer Prevention Fellowship Program.

    PubMed

    Husten, C G; Weed, D L; Kaluzny, A D

    1993-01-01

    NCI's Cancer Prevention Fellowship Program recently initiated a continuing evaluation of the fellows' demographics, fellows' accomplishments in the program, fellow and preceptor expectations and satisfaction, program strengths and weaknesses, current employment for former fellows, and ex-fellows' perceptions of program training. Evaluation shows that the program attracts quality applicants (including minorities and females) nationwide from many disciplines. The program successfully educates about cancer prevention and provides a positive preceptor experience with publication opportunities. Areas for improvement are data access, stipend, office space, job assistance, and networking. Recommendations for other programs include committed enthusiastic staff; adequate budget, space, and support; a formal learning experience in public health fundamentals, research methods, and cancer prevention; individual mentored research within a productive scientific program; aggressive recruitment; competitive admissions policy; defined objectives for fellows; and ongoing formal program evaluation. PMID:8186080

  16. Surgical anatomy of the minimally invasive lateral lumbar approach.

    PubMed

    Bina, Robert W; Zoccali, Carmine; Skoch, Jesse; Baaj, Ali A

    2015-03-01

    The lateral lumbar interbody fusion approach (LLIF), which encompasses the extreme lateral interbody fusion or direct lateral interbody fusion techniques, has gained popularity as an alternative to traditional posterior approaches. With rapidly expanding applications, this minimally invasive surgery (MIS) approach is now utilized in basic degenerative pathologies as well as complex lumbar degenerative deformities and tumors. Given the intimate relationship of the psoas muscle, and hence the lumbar plexus, to this MIS approach, several authors have examined the surgical anatomy of this approach. Understanding this regional neural anatomy is imperative given the potential for serious injuries to both the motor and sensory nerves of the lumbar plexus. In this review, we critically and comprehensively discuss all published studies detailing the surgical anatomy of the lateral lumbar approach with respect to the MIS LLIF techniques. This is a timely review given the rapidly growing number of surgeons utilizing this technique. PMID:25449209

  17. The teaching of anatomy: the first hundred years (1905-2005).

    PubMed

    Wong, W C; Tay, S S W

    2005-07-01

    The Straits and Federated Malay States Government Medical School started on 3 July 1905 with the admission of 16 young persons for the full 5-year course. In 1910, 7 successful candidates qualified as medical practitioners and they were no more than 19 years of age. The medical course was based largely on the British system and consisted of 2 years of training in the basic sciences followed by 3 years of clinical clerkships in Medicine, Surgery and Midwifery. Anatomy was taught in the first year and extended into the second year, using cadavers (which were possibly fixed in formalin and glycerin) as study materials. The first Chair of Anatomy was established in 1922 and with the provision of full-time staff, the curriculum was brought in line with those conducted in the British colonies. From the mid-1960s to the mid-1990s, the Anatomy course for medical students spanned 1 1/2 years, with special emphasis on clinical applications, thereby projecting the professional relevance of the course. Big class lectures introduced and previewed important structures that were encountered in dissections and small group tutorials reviewed the tutorial objectives that had been made available earlier. In the late 1990s and early 2000s, the medical curriculum was further revised to meet the challenges of the 21st century. A track system was developed and Human Anatomy came under the "Human Structure and Development Track". The original 1 1/2 -year programme was tailored into a 1-year programme with a drastic reduction in teaching/contact hours, but the big class lectures and small group tutorials plus dissections/prosections were retained. Beginning in the academic year 2003/2004, prosected cadavers (dissected by professional staff) were employed for teaching purposes due to a progressive fall in the availability of cadavers and time constraints imposed by the introduction of several new modules. Teachers demonstrate and students learn on prosected materials and the success of this new mode of teaching-learning can only be seen in the near future. PMID:16010382

  18. Wahlfach I: Funkt. und angewandte Anatomie Modul-Code: WP 242

    E-print Network

    Manstein, Dietmar J.

    Wahlfach I: Funkt. und angewandte Anatomie Modul-Code: WP 242 Wahlpflichtveranstaltung mit max. 12 Teilnehmern Thema: Anatomie im Röntgenbild Leitung: Dr. Sabine Dettmer Prof. Dr. A. Schmiedl Dozenten: Prof anatomischen Präparaten soll die Anatomie ausgewählter Organsysteme erarbeitet werden. Hierdurch soll das

  19. Wahlfach I: Funkt. und angewandte Anatomie Modul-Code: WP 240

    E-print Network

    Manstein, Dietmar J.

    Wahlfach I: Funkt. und angewandte Anatomie Modul-Code: WP 240 Wahlpflichtveranstaltung mit max. 12 Teilnehmern Thema: Klinische Bedeutung der topografischen Anatomie der Hand sowie anatomische Grundlagen von Lappenplastiken Leitung: Prof. Dr. B. Rieck, Hildesheim / Prof. Dr. A. Schmiedl, Funkt. und angewandte Anatomie

  20. Wahlfach I: Ansthesiologie und Intensivmedizin, Anatomie Modul-Code: WP 247

    E-print Network

    Manstein, Dietmar J.

    Wahlfach I: Anästhesiologie und Intensivmedizin, Anatomie Modul-Code: WP 247 Wahlpflichtveranstaltung mit mind. 10 bis max. 15 Teilnehmern Thema: Anatomy Meets Anesthesia Lehrverantwortlicher: Dr. Jan Anatomie, Präpariersäle (J2, S0, 1420, 1430) Art/Umfang der Lehrveranstaltung: 24 Std. (Freitag 17

  1. Naam: dhr. prof. dr. R.L.A.W. Bleys Leeropdracht Klinische anatomie

    E-print Network

    Utrecht, Universiteit

    Naam: dhr. prof. dr. R.L.A.W. Bleys Profiel Leeropdracht Klinische anatomie Faculteit Geneeskunde (GNK) Onderdeel Anatomie Contactgegevens Telefoon (+31) 88 756 8302 E-mail r de hersencirculatie en ontstekingsreacties. Virtuele 3D modellen in de anatomie en hun bijdragen

  2. Template estimation form unlabeled point set data and surfaces for Computational Anatomy

    E-print Network

    Paris-Sud XI, Université de

    Template estimation form unlabeled point set data and surfaces for Computational Anatomy Joan Glaun, University of Utah, scjoshi@gmail.com Abstract. A central notion in Computational Anatomy is the gener- ation Introduction A major focus of computational anatomy has been the development of image mapping algorithms [3

  3. Effectiveness of a Shortened, Clinically Engaged Anatomy Course for Physician Assistant Students

    NSDL National Science Digital Library

    William C Rando (Yale University McDougal Graduate Teaching Center)

    2011-03-01

    This article describes a study examining whether clinically engaged anatomy could be adapted from the medical school curriculum to the Physican Assistant curriculum (a truncated version). Clinically engaged anatomy is a course that presents anatomy entirely within the context of common clinical cases. Methods and outcomes on student learning, particularly spatial reasoning and structure function relationships are discussed.

  4. Effectiveness of a Shortened, Clinically Engaged Anatomy Course for Physician Assistant Students

    ERIC Educational Resources Information Center

    Rizzolo, Lawrence J.; Rando, William C.; O'Brien, Michael K.; Garino, Alexandria; Stewart, William B.

    2011-01-01

    There is little consensus among programs that train physician assistants (PAs) regarding how much time should be devoted to the study of anatomy, what should be included, or how it should be taught. Similar concerns led us to redesign anatomy for medical students and introduce clinically engaged anatomy, an approach designed in collaboration with…

  5. Is Student Knowledge of Anatomy Affected by a Problem-Based Learning Approach? A Review

    ERIC Educational Resources Information Center

    Williams, Jonathan M.

    2014-01-01

    A fundamental understanding of anatomy is critical for students on many health science courses. It has been suggested that a problem-based approach to learning anatomy may result in deficits in foundation knowledge. The aim of this review is to compare traditional didactic methods with problem-based learning methods for obtaining anatomy

  6. Evaluation of 3D Model Segmentation Techniques based on Animal Anatomy

    E-print Network

    Lavoué, Guillaume

    Evaluation of 3D Model Segmentation Techniques based on Animal Anatomy Nasim Hajari, Irene Cheng impossible. In this paper we suggest to use animal anatomy as the ground truth and compare the result knowledge on anatomy of various animals. Based on this knowledge we specify the ground truth for different

  7. Anatomy Based 3D Dose Optimization in Brachytherapy Using Multiobjective Genetic Algorithms

    E-print Network

    Coello, Carlos A. Coello

    Anatomy Based 3D Dose Optimization in Brachytherapy Using Multiobjective Genetic Algorithms M: Anatomy Based 3D Dose Optimization .... Page 2 of 2 Abstract In conventional dose optimization algorithms in terms of the COIN distribution and differential volume histograms, taking into account patient anatomy

  8. ANATOMY AND HISTOLOGY OF THE GENITAL TRACT, SPERMATHECA, SPERMATHECAL DUCT AND GLANDS OF

    E-print Network

    Paris-Sud XI, Université de

    ANATOMY AND HISTOLOGY OF THE GENITAL TRACT, SPERMATHECA, SPERMATHECAL DUCT AND GLANDS OF APIS) and others have published new data about anatomy and insemination techniques. Lately, some modifications 230 mg. In this paper we present detailed information about anatomy and histology of the tract, mainly

  9. Functional Anatomy of the Arm for Muscle Forces Estimation C. Pontonnier1

    E-print Network

    Paris-Sud XI, Université de

    Functional Anatomy of the Arm for Muscle Forces Estimation C. Pontonnier1 , G. Dumont2 1. ABSTRACT This article presents how we use functional anatomy to develop a simplified model of the arm usable to estimate techniques are based on functional anatomy [6][7]. As we want to add a dynamical criterion to the postural

  10. Biol111 Course Syllabus1 Biol 111 Comparative and Human Anatomy

    E-print Network

    Bergmann, Philip J.

    Biol111 Course Syllabus1 Biol 111 ­ Comparative and Human Anatomy Course Syllabus Spring 2015@clarku.edu Office hours: Thursday 10:15-11:15, or by appointment Lab TA: Gen Morinaga Office: Lasry 150 (Anatomy Lab Required: · Liem, K.F., Bemis, W.E., Walker Jr., W.F. & Grande, L. 2001. Functional Anatomy

  11. Micro-CT study of the anatomy of the Leafhopper Homalodisca vitripennis (Hemiptera: Cicadellidae)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A Digital Anatomy Library, DAL, was produced to the anatomy of the glassy-winged sharpshooter adult, Homalodisca vitripennis (Hemiptera: Cicadellidae), vector of bacteria which cause Pierce’s disease of grapevines. The insect anatomy was elucidated using a high resolution Bruker Skyscan 1172 micro t...

  12. Anatomy of a Research Report--Part I Nesting habits of sparrows in

    E-print Network

    Dyer, Bill

    Anatomy of a Research Report--Part I Nesting habits of sparrows in five sparse canopies Roberta: · dependent variables: · independent variables: · conclusions: · recommendations: #12;Anatomy of a Research--why was this method chosen? #12;Anatomy of a Research Report--Part II Everything before the Results section explains

  13. 422 Department of Anatomy, Cell Biology and Physiological Sciences Graduate Catalogue 201415

    E-print Network

    degree in Human Morphology (Anatomy and Cell Biology), Physiology and in Neuroscience. Students with a BS Anatomy 24.198; 7 cr. A regional dissection of the entire human body supplemented by embryology, clinical422 Department of Anatomy, Cell Biology and Physiological Sciences Graduate Catalogue 2014

  14. Bio 2430 Anatomy and Physiology Lab. General information and policies. Lab manual

    E-print Network

    Aspbury, Andrea S. - Department of Biology, Texas State University

    Bio 2430 Anatomy and Physiology Lab. General information and policies. Lab manual : Human A & P Lab the structure and function of the human body. Most of the anatomy sections of the course are primarily covered attempt at learning human anatomy and physiology enjoyable and profitable. The lab schedule gives you

  15. Challenges in Precisely Aligning Models of Human Anatomy Using Generic Schema Matching

    E-print Network

    Pottinger, Rachel

    Challenges in Precisely Aligning Models of Human Anatomy Using Generic Schema Matching Peter large models of human anatomy. We summarize the generic schema matching algorithms we used to identify the centuries allows physicians to share observations and diag- noses. Human anatomy has been encoded in two

  16. Linking Ontologies with Three-Dimensional Models of Anatomy to Predict the Effects of Penetrating Injuries

    E-print Network

    Rubin, Daniel L.

    model of the heart from the Visible Human image data set. We linked this geometric model of anatomy body of explicit declarative knowledge about human anatomy (Figure 1). The FMA provides formalLinking Ontologies with Three-Dimensional Models of Anatomy to Predict the Effects of Penetrating

  17. Pocket atlas of head and neck MRI anatomy

    SciTech Connect

    Lufkin, R.B.; Hanafee, W.N.

    1989-01-01

    This pocket atlas depicts the anatomy of the head and neck as seen in magnetic resonance (MR) images. The collection of 140 high-resolution images covers all major areas - neck, larynx, oropharynx, tongue, nasopharynx, skull base, sinuses, and temporal bone - displayed in sagittal, axial, and coronal MR image planes. The images show maximum fat/muscle contrast for better visualization of fascial planes. In certain areas of the anatomy, such as the neck and temporal bone, surface coils were used to achieve significant advantages in image quality over standard head or body coils.

  18. Interprofessional education in anatomy: Learning together in medical and nursing training.

    PubMed

    Herrmann, Gudrun; Woermann, Ulrich; Schlegel, Claudia

    2014-12-01

    Teamwork and the interprofessional collaboration of all health professions are a guarantee of patient safety and highly qualified treatment in patient care. In the daily clinical routine, physicians and nurses must work together, but the education of the different health professions occurs separately in various places, mostly without interrelated contact. Such training abets mutual misunderstanding and cements professional protectionism, which is why interprofessional education can play an important role in dismantling such barriers to future cooperation. In this article, a pilot project in interprofessional education involving both medical and nursing students is presented, and the concept and the course of training are described in detail. The report illustrates how nursing topics and anatomy lectures can be combined for interprofessional learning in an early phase of training. Evaluation of the course showed that the students were highly satisfied with the collaborative training and believed interprofessional education (IPE) to be an important experience for their future profession and understanding of other health professionals. The results show that the IPE teaching concept, which combines anatomy and nursing topics, provides an optimal setting for learning together and helps nurses and doctors in training to gain knowledge about other health professionals' roles, thus evolving mutual understanding. Anat Sci Educ. © 2014 American Association of Anatomists. PMID:25475829

  19. The gross anatomy laboratory: a novel venue for critical thinking and interdisciplinary teaching in dental education.

    PubMed

    Rowland, Kevin C; Joy, Anita

    2015-03-01

    Reports on the status of dental education have concluded that there is a need for various types of curricular reform, making recommendations that include better integration of basic, behavioral, and clinical sciences, increased case-based teaching, emphasis on student-driven learning, and creation of lifelong learners. Dental schools faced with decreasing contact hours, increasing teaching material, and technological advancements have experimented with alternate curricular strategies. At Southern Illinois University School of Dental Medicine, curricular changes have begun with a series of integrated biomedical sciences courses. During the process of planning and implementing the integrated courses, a novel venue-the gross anatomy laboratory-was used to introduce all Year 1 students to critical thinking, self-directed learning, and the scientific method. The venture included student-driven documentation of anatomical variations encountered in the laboratory using robust scientific methods, thorough literature review, and subsequent presentation of findings in peer review settings. Students responded positively, with over 75% agreeing the experience intellectually challenged them. This article describes the process of re-envisioning the gross anatomy laboratory as an effective venue for small group-based, student-driven projects that focus on key pedagogical concepts to encourage the development of lifelong learners. PMID:25729023

  20. A Functional Perspective on the Embryology and Anatomy of the Cerebral Blood Supply

    PubMed Central

    Menshawi, Khaled; Mohr, Jay P

    2015-01-01

    The anatomy of the arterial system supplying blood to the brain can influence the development of arterial disease such as aneurysms, dolichoectasia and atherosclerosis. As the arteries supplying blood to the brain develop during embryogenesis, variation in their anatomy may occur and this variation may influence the development of arterial disease. Angiogenesis, which occurs mainly by sprouting of parent arteries, is the first stage at which variations can occur. At day 24 of embryological life, the internal carotid artery is the first artery to form and it provides all the blood required by the primitive brain. As the occipital region, brain stem and cerebellum enlarge; the internal carotid supply becomes insufficient, triggering the development of the posterior circulation. At this stage, the posterior circulation consists of a primitive mesh of arterial networks that originate from projection of penetrators from the distal carotid artery and more proximally from carotid-vertebrobasilar anastomoses. These anastomoses regress when the basilar artery and the vertebral arteries become independent from the internal carotid artery, but their persistence is not uncommon in adults (e.g., persistent trigeminal artery). Other common remnants of embryological development include fenestration or duplication (most commonly of the basilar artery), hypoplasia (typically of the posterior communicating artery) or agenesis (typically of the anterior communicating artery). Learning more about the hemodynamic consequence that these variants may have on the brain territories they supply may help understand better the underlying physiopathology of cerebral arterial remodeling and stroke in patients with these variants.

  1. Single-shot T1 mapping of the corpus callosum: a rapid characterization of fiber bundle anatomy

    PubMed Central

    Hofer, Sabine; Wang, Xiaoqing; Roeloffs, Volkert; Frahm, Jens

    2015-01-01

    Using diffusion-tensor magnetic resonance imaging and fiber tractography the topographic organization of the human corpus callosum (CC) has been described to comprise five segments with fibers projecting into prefrontal (I), premotor and supplementary motor (II), primary motor (III), and primary sensory areas (IV), as well as into parietal, temporal, and occipital cortical areas (V). In order to more rapidly characterize the underlying anatomy of these segments, this study used a novel single-shot T1 mapping method to quantitatively determine T1 relaxation times in the human CC. A region-of-interest analysis revealed a tendency for the lowest T1 relaxation times in the genu and the highest T1 relaxation times in the somatomotor region of the CC. This observation separates regions dominated by myelinated fibers with large diameters (somatomotor area) from densely packed smaller axonal bundles (genu) with less myelin. The results indicate that characteristic T1 relaxation times in callosal profiles provide an additional means to monitor differences in fiber anatomy, fiber density, and gray matter in respective neocortical areas. In conclusion, rapid T1 mapping allows for a characterization of the axonal architecture in an individual CC in less than 10 s. The approach emerges as a valuable means for studying neocortical brain anatomy with possible implications for the diagnosis of neurodegenerative processes. PMID:26029059

  2. Aerial organ anatomy of Smilax syphilitica (Smilacaceae).

    PubMed

    Silva, João Marcelo; Andreata, Regina Helena Potsch; Appezzato-da-Glória, Beatriz

    2012-09-01

    Smilax L. in Brazil is represented by 32 taxa and it is a taxonomically difficult genus because the plants are dioecious and show wide phenotypic variation. The analysis and use of leaf anatomy characters is recognized as a frequently successful taxonomic method to distinguish between individual taxon, when floral material is absent or minute differences in flowers and foliage exist such as in Smilax. The aim of this study was to characterize the anatomical features of the aerial organs in Smilax syphilitica collected from the Atlantic Rainforest, in Santa Teresa-ES and the Smilax aff. syphilitica from the Amazon Rainforest, in Manaus, Brazil. For this, a total of three samples of Smilax were collected per site. Sample leaves and stems were fixed with FAA 50, embedded in historesin, sectioned on a rotary microtome, stained and mounted in synthetic resin. Additionally, histochemical tests were performed and cuticle ornamentation was analyzed with standard scanning electron microscopy. S. syphilitica and S. aff. syphilitica differed in cuticle ornamentation, epidermal cell arrangement and wall thickness, stomata type and orientation, calcium oxalate crystal type, and position of stem thorns. Leaf blades of S. syphilitica from the Amazon Rainforest have a network of rounded ridges on both sides, while in S. aff. syphilitica, these ridges are parallel and the spaces between them are filled with numerous membranous platelets. Viewed from the front, the epidermal cells of S. syphilitica have sinuous walls (even more pronounced in samples from the Amazon); while in S. aff. syphilitica, these cells are also sinuous but elongated in the cross-section of the blade and arranged in parallel. Stomata of S. syphilitica are paracytic, whereas in S. aff. syphilitica, are both paracytic and anisocytic, and their polar axes are directed towards the mid-vein. Calcium oxalate crystals in S. syphilitica are prisms, whereas in S. aff. syphilitica, crystal sand. Thorns occur in nodes and internodes in S. syphilitica but only in internodes in S. af. syphilitica. These features have proven to be of diagnostic value and may support a separation into two species, but future studies are needed to confirm that S. aff. syphilitica is indeed a new taxon. PMID:23025085

  3. Exercises in anatomy: holes between the ventricles.

    PubMed

    Anderson, Robert H; Sarwark, Anne E; Spicer, Diane E; Backer, Carl L

    2014-01-01

    Holes between the ventricles are the commonest congenital cardiac malformations. As yet, however, there is no consensus as to how they can best be described and categorized. In this, our third exercise in cardiac anatomy, we address the issue of classification of ventricular septal defects. We begin our demonstration by analysing the normal heart. We show that the larger part of the ventricular septum is made up of its muscular component. The membranous part accounts for only a small portion, which is located centrally within the cardiac base. This small membranous part forms a boundary between the right-sided chambers and the aortic root. Holes at this site, therefore, which account for the commonest defects closed surgically, will open centrally in the cardiac base, being located postero-inferiorly relative to the supraventricular crest. We then show that the larger part of the crest itself is a free-standing muscular sleeve, which lifts the leaflets of the pulmonary valve away from the cardiac base. Only a very small part of the muscle forming the right ventricular outlet is located in the septal position. Turning our attention to malformed hearts, we show how holes between the ventricles can open centrally at the cardiac base, open to the inlet or outlet of the right ventricle or open within the substance of the apical muscular septum. We demonstrate, however, that description of such geographical location of the defects does not paint the full picture, since lesions with markedly different phenotypic features can open in comparable geographic locations. We illustrate how it is the phenotypic features, as seen from the right ventricle, which convey the crucial information for the surgeon with regard to the location of the atrioventricular conduction axis, using hearts with holes opening to the inlet of the right ventricle with muscular as opposed to partially fibrous borders to emphasize this point. We continue by showing how holes with different phenotypes can also open to the outlet of the right ventricle, the key feature in this regard being malalignment between the apical muscular septum relative to the muscular outlet septum or its fibrous remnant. Malalignment can also be found between the apical ventricular septum and the atrial septum, this being shown in a defect opening to the inlet of the right ventricle. We conclude by emphasizing that, so as to bring together all the information of surgical significance, it is necessary to take note of the geographical location of holes between the ventricles, their phenotypic features and the presence or absence of malalignment between the septal components. PMID:25547619

  4. CRN Projects

    Cancer.gov

    Most cancer cost estimates are from the NCI's SEER cancer registries linked to Medicare claims (SEER-Medicare). These data only represent the experience of the more than 80% of aged Medicare beneficiaries enrolled in the fee-for-service (FFS) indemnity option; no information is available about the remaining seniors enrolled in Medicare HMOs.

  5. Digital dissection system for medical school anatomy training

    NASA Astrophysics Data System (ADS)

    Augustine, Kurt E.; Pawlina, Wojciech; Carmichael, Stephen W.; Korinek, Mark J.; Schroeder, Kathryn K.; Segovis, Colin M.; Robb, Richard A.

    2003-05-01

    As technology advances, new and innovative ways of viewing and visualizing the human body are developed. Medicine has benefited greatly from imaging modalities that provide ways for us to visualize anatomy that cannot be seen without invasive procedures. As long as medical procedures include invasive operations, students of anatomy will benefit from the cadaveric dissection experience. Teaching proper technique for dissection of human cadavers is a challenging task for anatomy educators. Traditional methods, which have not changed significantly for centuries, include the use of textbooks and pictures to show students what a particular dissection specimen should look like. The ability to properly carry out such highly visual and interactive procedures is significantly constrained by these methods. The student receives a single view and has no idea how the procedure was carried out. The Department of Anatomy at Mayo Medical School recently built a new, state-of-the-art teaching laboratory, including data ports and power sources above each dissection table. This feature allows students to access the Mayo intranet from a computer mounted on each table. The vision of the Department of Anatomy is to replace all paper-based resources in the laboratory (dissection manuals, anatomic atlases, etc.) with a more dynamic medium that will direct students in dissection and in learning human anatomy. Part of that vision includes the use of interactive 3-D visualization technology. The Biomedical Imaging Resource (BIR) at Mayo Clinic has developed, in collaboration with the Department of Anatomy, a system for the control and capture of high resolution digital photographic sequences which can be used to create 3-D interactive visualizations of specimen dissections. The primary components of the system include a Kodak DC290 digital camera, a motorized controller rig from Kaidan, a PC, and custom software to synchronize and control the components. For each dissection procedure, the images are captured automatically, and then processed to generate a Quicktime VR sequence, which permits users to view an object from multiple angles by rotating it on the screen. This provides 3-D visualizations of anatomy for students without the need for special '3-D glasses' that would be impractical to use in a laboratory setting. In addition, a digital video camera may be mounted on the rig for capturing video recordings of selected dissection procedures being carried out by expert anatomists for playback by the students. Anatomists from the Department of Anatomy at Mayo have captured several sets of dissection sequences and processed them into Quicktime VR sequences. The students are able to look at these specimens from multiple angles using this VR technology. In addition, the student may zoom in to obtain high-resolution close-up views of the specimen. They may interactively view the specimen at varying stages of dissection, providing a way to quickly and intuitively navigate through the layers of tissue. Electronic media has begun to impact all areas of education, but a 3-D interactive visualization of specimen dissections in the laboratory environment is a unique and powerful means of teaching anatomy. When fully implemented, anatomy education will be enhanced significantly by comparison to traditional methods.

  6. 5 a day for better health—nine community research projects to increase fruit and vegetable consumption

    PubMed Central

    Havas, Stephen; Heimendinger, Jerianne; Damron, Dorothy; Nicklas, Theresa A.; Cowan, Arnette; Beresford, Shirley A. A.; Sorensen, Glorian; Buller, David; Bishop, Donald; Baranowski, Tom; Reynolds, Kim

    1995-01-01

    One of the national objectives in “Healthy People 2000” is for members of the public to increase their consumption of fruits and vegetables to five or more servings daily. The National Cancer Institute (NCI) began a nationwide campaign to achieve this objective in 1991. As part of this campaign, the NCI funded nine research studies in 1993. These projects are implementing and evaluating community-based programs designed to increase fruit and vegetable consumption among different segments of the population in Alabama, Arizona, Georgia, Louisiana, Maryland, Massachusetts, Minnesota, North Carolina, and Washington. The settings for these projects include the Special Supplement Food Program for Women, Infants, and Children (WIC Programs), churches, worksites, and schools. The projects are led by multidisciplinary teams and entail extensive collaboration among academic, governmental, private sector, and voluntary agencies within each State. The projects represent a model public health paradigm for conducting this type of research. PMID:7838947

  7. The relevance of anatomy and morbid anatomy for medical practice and hence for postgraduate and continuing medical education of doctors.

    PubMed Central

    Crisp, A. H.

    1989-01-01

    A case is presented for the durability of anatomy including dissection of the cadaver and of morbid anatomy as elements in medical education and practice. It is these subjects, as consistently relevant over the centuries for medical practice as are communication skills, that are our hallmark as doctors. It is submitted that we should take stock very carefully of their relevance to us before it is too late easily to redress the balance, given the major trends of the last two decades. PMID:2594599

  8. Requirements for an on-line knowledge-based anatomy information system.

    PubMed Central

    Brinkley, J. F.; Rosse, C.

    1998-01-01

    User feedback from the Digital Anatomist Web-based anatomy atlases, together with over 20 years of anatomy teaching experience, were used to formulate the requirements and system design for a next-generation anatomy information system. The main characteristic of this system over current image-based approaches is that it is knowledge-based. A foundational model of anatomy is accessed by an intelligent agent that uses its knowledge about the available anatomy resources and the user types to generate customized interfaces. Current usage statistics suggest that even partial implementation of this design will be of great practical value for both clinical and educational needs. Images Figure 1 PMID:9929347

  9. Attitudes of Healthcare Students on Gross Anatomy Laboratory Sessions

    ERIC Educational Resources Information Center

    Kawashiro, Yukiko; Anahara, Reiko; Kohno, Toshihiko; Mori, Chisato; Matsuno, Yoshiharu

    2009-01-01

    At Chiba University, gross anatomy laboratory sessions ("laboratories") are required for physical therapy students. Though most physical therapy schools require their students to participate in laboratories so that they will better understand the structure of the human body, few data exist on the value of these laboratories specifically for…

  10. Diffusion of Innovations: Smartphones and Wireless Anatomy Learning Resources

    ERIC Educational Resources Information Center

    Trelease, Robert B.

    2008-01-01

    The author has previously reported on principles of diffusion of innovations, the processes by which new technologies become popularly adopted, specifically in relation to anatomy and education. In presentations on adopting handheld computers [personal digital assistants (PDAs)] and personal media players for health sciences education, particular…

  11. KATRINA E. JONES Functional Anatomy and Evolution, Suite 305,

    E-print Network

    of Vertebrate Paleontology (Platform talk). 4. Jones, K. E. and Ruff, C. B. 2011. Male-male combat drives bite carnivorans. Society of Vertebrate Paleontology Program and Abstracts book. P113A. (Platform talk). 6. Jones in tree incongruency. Symposium of Vertebrate Paleontology and Comparative Anatomy (Platform talk). 7

  12. Diffusion of innovations: Smartphones and Wireless Anatomy Learning Resources

    NSDL National Science Digital Library

    Dr. Robert B Trelease (UCLA Center for Health Sciences Department of Pathology and Laboratory Medicine)

    2008-12-04

    This article describes the effectiveness (both beneficial and non-beneficial) of PDA technology in anatomy education. Included is a focus of how instructors versus student adapt and use technology and a recommendation for the use of the Apple iPhone technology over other PDA devices.

  13. Anatomy of cirrus clouds: Results from the Emerald airborne campaigns

    Microsoft Academic Search

    James Whiteway; Clive Cook; Martin Gallagher; Tom Choularton; John Harries; Paul Connolly; Reinhold Busen; Keith Bower; Michael Flynn; Peter May; Robin Aspey; Jorg Hacker

    2004-01-01

    The Emerald airborne measurement campaigns have provided a view of the anatomy of cirrus clouds in both the tropics and mid-latitudes. These experiments have involved two aircraft that combine remote sensing and in-situ measurements. Results are presented here from two separate flights: one in frontal cirrus above Adelaide, Australia, the other in the cirrus outflow from convection above Darwin. Recorded

  14. Standard methods for Apis mellifera anatomy and dissection

    Technology Transfer Automated Retrieval System (TEKTRAN)

    An understanding of the anatomy and functions of internal and external structures are fundamental to many studies on the honey bee Apis mellifera. Similarly, proficiency in dissection techniques is vital for many more complex procedures. In this paper, which is a prelude to the other papers of the C...

  15. Tele-Immersion: Preferred Infrastructure for Anatomy Instruction

    ERIC Educational Resources Information Center

    Silverstein, Jonathan C.; Ehrenfeld, Jesse M.; Croft, Darin A.; Dech, Fred W.; Small, Stephen; Cook, Sandy

    2006-01-01

    Understanding spatial relationships among anatomic structures is an essential skill for physicians. Traditional medical education--using books, lectures, physical models, and cadavers--may be insufficient for teaching complex anatomical relationships. This study was designed to measure whether teaching complex anatomy to medical students using…

  16. Teaching Bovine Abdominal Anatomy: Use of a Haptic Simulator

    ERIC Educational Resources Information Center

    Kinnison, Tierney; Forrest, Neil David; Frean, Stephen Philip; Baillie, Sarah

    2009-01-01

    Traditional methods of teaching anatomy to undergraduate medical and veterinary students are being challenged and need to adapt to modern concerns and requirements. There is a move away from the use of cadavers to new technologies as a way of complementing the traditional approaches and addressing resource and ethical problems. Haptic (touch)…

  17. Anatomy Drawing Screencasts: Enabling Flexible Learning for Medical Students

    ERIC Educational Resources Information Center

    Pickering, James D.

    2015-01-01

    The traditional lecture remains an essential method of disseminating information to medical students. However, due to the constant development of the modern medical curriculum many institutions are embracing novel means for delivering the core anatomy syllabus. Using mobile media devices is one such way, enabling students to access core material…

  18. Development of a Synergistic Case-Based Micro anatomy Curriculum

    ERIC Educational Resources Information Center

    McBride, Jennifer M.; Prayson, Richard A.

    2008-01-01

    This paper discusses the development of an interactive approach to teaching and assessing a micro anatomy curriculum in an innovative medical school program. As an alternative to lectures and labs, students are engaged in interactive seminars focused on discussion of clinical and research-based cases matched with normal histology and pathology…

  19. Anatomy and Selected Biomechanical Aspects of the Shoulder.

    ERIC Educational Resources Information Center

    Keene, James S.

    This paper focuses on the anatomy and functions of the shoulder that are relevant to the evaluation and treatment of athletic injuries. A discussion is presented on the four basic components of the shoulder mechanism: (1) super structure--bony components; (2) moving parts--joints involved; (3) motor power--musculature; and (4) communications…

  20. The anatomy and physiology of the ocular motor system

    Microsoft Academic Search

    Anja K. E. Horn; R. John Leigh

    2011-01-01

    Accurate diagnosis of abnormal eye movements depends upon knowledge of the purpose, properties, and neural substrate of distinct functional classes of eye movement. Here, we summarize current concepts of the anatomy of eye movement control. Our approach is bottom-up, starting with the extraocular muscles and their innervation by the cranial nerves. Second, we summarize the neural circuits in the pons