Sample records for andoh hideo ikeda

  1. Daisaku Ikeda and the Culture of Translation

    ERIC Educational Resources Information Center

    Gebert, Andrew

    2012-01-01

    Although not functionally multilingual or a translator himself, Daisaku Ikeda has been deeply involved in translation processes, both as a reader and as someone who has produced texts for translation into various languages. This article examines two sources of influence shaping Ikeda's attitude toward translation culture: the flourishing culture…

  2. Daisaku Ikeda's Educational Philosophy in the Context of English Education Policy in Japan

    ERIC Educational Resources Information Center

    Hatano, Kazuma

    2012-01-01

    In this article, the author considers Daisaku Ikeda's (1928-) educational philosophy in the context of English education policies in Japan. The author begins by explicating Ikeda's concepts of wisdom versus knowledge and "society for education" (e.g., Ikeda, 2000; Sadovnichy & Ikeda, 2002). He then suggests consideration of these…

  3. Restructuring the Ikeda City school urinary screening system: report of a screening survey

    PubMed Central

    2013-01-01

    Background Annual urinary screening is conducted at municipal kindergartens, elementary schools, and junior high schools in Ikeda City, Osaka, Japan (Ikeda City School System), and the results are reviewed by a general physician, but standards for when to recommend specialist referral have not been clear. Methods In all children attending the Ikeda City School System in 2012, dipstick urinalysis of a first-morning urine specimen was recommended once or twice, and if a second urinalysis showed proteinuria (≥1+), the urinary protein/creatinine ratio was measured. If this showed ≥0.2 g/g of creatinine (g/gCr), it was recommended that the child be evaluated by a specialist at Ikeda City Hospital. Results Urinary screening was performed in about 20% (388) of kindergarten, about 90% (5363) of elementary school, and about 86% (2523) of junior high school children living in Ikeda City. Urine samples were obtained from 387, 5349, and 2476 children, respectively. The urinary protein/creatinine ratio was ≥0.2 g/gCr in 13 children, including 1 elementary and 12 junior high children. In these 13 children, chronic nephritic syndrome (CNS) was suspected in 6 junior high school children, and of these, this was a new finding in 5, and renal biopsy was indicated in 3. In Ikeda City, the prevalence of CNS in elementary school children was <0.03%, the prevalence of CNS in junior high school children was 0.29%, and a renal biopsy was indicated in 0.14%. By eliminating the costs associated with assessment of the results by the Ikeda Medical Association, and by directly contracting with the testing company, the expenses paid by Ikeda City for the system itself decreased from 2,508,619 yen to 966,157 yen. Conclusions Incorporating the urinary protein/creatinine ratio into the school urinary screening system in the Ikeda City School System and clarifying standards for specialist referral has enabled restructuring of the system so that is efficient and its effectiveness can be

  4. Ikeda Research in China and Taiwan: Critical Analysis of the Chinese Language Literature

    ERIC Educational Resources Information Center

    Inukai, Nozomi

    2012-01-01

    This study is the first attempt to conduct a critical analysis of the research on Ikeda's educational philosophy published in mainland China and Taiwan. The study employed a combination of archival research and responses to an online questionnaire by professors and doctorate students studying Ikeda's educational philosophy. The study analyzed the…

  5. Daisaku Ikeda's Curriculum of Soka Education: Creating Value through Dialogue, Global Citizenship, and "Human Education" in the Mentor-Disciple Relationship

    ERIC Educational Resources Information Center

    Goulah, Jason; Ito, Takao

    2012-01-01

    This essay review focuses on Daisaku Ikeda (b. 1928) and his curriculum of Soka, or value-creating, education present in two works: "Choose Life: A Dialogue" (Toynbee & Ikeda, 1976) and "Thoughts on Education for Global Citizenship" (Ikeda, 1996b). In reviewing these works, the authors trace the biographical roots of Ikeda's educational philosophy…

  6. Lessons from Afar: A Review of www.daisakuikeda.org, Official Website of Daisaku Ikeda

    ERIC Educational Resources Information Center

    Arauz, Luis

    2012-01-01

    Daisaku Ikeda (1928- ) is a Buddhist leader, peace builder, school founder, and poet. His own biography and lifework provide a model for how one can transform adversity into alternative opportunities for some of the most disenfranchised students. Scrutinizing Ikeda's official website (www.daisakuikeda.org) reveals an extensive collection of his…

  7. Daisaku Ikeda and Value-Creative Dialogue: A New Current in Interculturalism and Educational Philosophy

    ERIC Educational Resources Information Center

    Goulah, Jason

    2012-01-01

    This article focuses on Daisaku Ikeda's (1928- ) philosophy and practice of intercultural dialogue--what I call "value-creative dialogue"--as a new current in interculturalism and educational philosophy and theory. I use excerpts from Ikeda's writings to consider two aspects of his approach to dialogue. First, I locate his approach…

  8. Monitoring Theileria orientalis (Ikeda)-associated bovine anaemia in affected cattle over time.

    PubMed

    McFadden, Amj; Hart, M; Bueno, I M; Ha, H J; Heath, Acg; Pulford, D J

    2017-10-15

    The aim of the study was to observe changes in haematocrit (HCT) over time in a New Zealand South Island dairy herd affected by an outbreak of Theileria-associated bovine anaemia (TABA; Ikeda). A secondary aim was to relate individual cow HCTs to the amount of Theileria orientalis Ikeda DNA present in the blood, as measured by cycle threshold values, using a quantitative PCR (qPCR). Over a 6 month period, blood samples from 19 randomly selected cattle were monitored from a herd of 600 dairy cows. The sampling interval was approximately fortnightly for the first six weeks, followed by sampling at between four and six week intervals. At the initial report of the outbreak, two from six cattle were anaemic (HCT<0.25L/L). Blood collected from 14 cattle 11 days later showed that 57% (95% CI 33-77%) of the cattle sampled were anaemic. Of the 19 cattle that went on to be monitored, 12 (63% 95% CI=41-81%) developed anaemia at some point during the period of monitoring. One of the anaemic animals did not meet the case definition for TABA Ikeda. For individual cattle, the average number of days between when cattle were first detected as anaemic and when HCT returned to normal was 53days (median=47 days, range=6-92 days). At the point of notification the amount of T. orientalis Ikeda DNA in the blood of the six cattle tested was low (Cq median=36), but 11days later the amount of DNA in blood of 14 additional cows tested was relatively high (Cq median=24). Levels of all 19 cows monitored continued to remain moderately high through the period of testing (Cq median=29). This was despite a general improvement in the HCT of affected cattle. In four of the 15 cattle positive to T. orientalis Ikeda where blood fractions (plasma and whole blood) were tested, it appeared that T. orientalis Ikeda (as measured by qPCR) dropped more rapidly in plasma fractions than in whole blood at the point that HCT started to return to normal levels. Despite the assumption that tick populations were

  9. Daisaku Ikeda's Philosophy of Peace, Education Proposals, and Soka Education: Convergences and Divergences in Peace Education

    ERIC Educational Resources Information Center

    Goulah, Jason; Urbain, Olivier

    2013-01-01

    In this article, the authors introduce and explicate Daisaku Ikeda's contributions to peace education. Ikeda is a Buddhist leader, peacebuilder, school founder, and prolific author whose six decades of contributions to peace education have had a global impact in practice but have remained unexamined in the extant, particularly Anglophone,…

  10. Realizing Daisaku Ikeda's Educational Philosophy through Language Learning and Study Abroad: A Critical Instrumental Case Study

    ERIC Educational Resources Information Center

    Goulah, Jason

    2012-01-01

    This article focuses in two ways on Daisaku Ikeda (b. 1928) and language and culture education. First, the author excerpts Ikeda's translated and lesser-known Japanese speeches to explicate his view of world language learning and cultural exchange as curricular components of a broader educational philosophy for becoming "fully human." Second, the…

  11. Developing high throughput quantitative PCR assays for diagnosing Ikeda and other Theileria orientalis types common to New Zealand in bovine blood samples.

    PubMed

    Pulford, D J; Gias, E; Bueno, I M; McFadden, Amj

    2016-01-01

    To develop rapid, quantitative PCR (qPCR) assays using high resolution melt (HRM) analysis and type-specific TaqMan assays for identifying the prevalent types of Theileria orientalis found in New Zealand cattle; and to evaluate their analytical and diagnostic characteristics compared with other assays for T. orientalis. Nucleotide sequences aligned with T. orientalis Buffeli, Chitose and Ikeda types, obtained from DNA extracted from blood samples from infected cattle, were used to design HRM and type-specific probe-based qPCR assays. The three type-specific assays were also incorporated into a single-tube multiplex qPCR assay. These assays were validated using DNA extracted from blood samples from cattle in herds with or without clinical signs of T. orientalis infection, other veterinary laboratory samples, as well as plasmids containing T. orientalis type-specific sequences. Diagnostic specificity (DSp) and sensitivity (DSe) estimates for the qPCR assays were compared to blood smear piroplasm results, and other PCR assays for T. orientalis. Copy number estimates of Ikeda DNA in blood were determined from cattle exhibiting anaemia using the Ikeda-specific qPCR assay. The T. orientalis type-specific and the HRM qPCR assays displayed 100% analytical specificity. The Ikeda-specific qPCR assay exhibited linearity (R(2) = 0.997) with an efficiency of 94.3%. Intra-assay CV were ≤0.08 and inter-assay CV were ≤0.095. For blood samples from cows with signs of infection with T. orientalis, the DSp and DSe of the multiplex probe qPCR assay were 93 and 96%, respectively compared with blood smears, and 97 and 100%, respectively compared with conventional PCR assays. For the Ikeda-specific qPCR assay, the number of positive samples (n=66) was slightly higher than a conventional PCR assay (n=64). The concentration of Ikeda genomes in blood samples from 41 dairy cows with signs of infection with T. orientalis ranged between 5.6 × 10(4) and 3.3 × 10(6) genomes per

  12. Application of quantitative PCR assays for diagnosing Ikeda and other Theileria orientalis types to examine associations between severity of anaemia and parasitaemia in bovine anaemia outbreaks.

    PubMed

    Gias, E; Pulford, D J; Lawrence, K; McFadden, Amj

    2016-01-01

    To use quantitative PCR assays to detect Theileria orientalis Ikeda type in cattle presumed infected with T. orientalis, to examine the relationship between theilerial piroplasm count and haematocrit (HCT), and the relationship with quantification cycle threshold (Cq) values. Blood samples in EDTA (n=1,024), derived from herds affected by anaemia associated with T. orientalis infection (TABA) between April and October 2013, were submitted for testing using quantitative PCR (qPCR) assays for T. orientalis and Ikeda type. Nucleotide sequencing of the major piroplasm surface protein (MPSP) gene was performed on 16 samples to identify T. orientalis types. Blood smear and/or HCT results were supplied with most samples. For data analysis, the number of theilerial piroplasm per 1,000 erythrocytes counted was categorised as negative (0), low (1-9), moderate (10-100) or high (>100). HCT was categorised as severely anaemic (<0.15 L/L), mildly anaemic (0.15-0.24 L/L) or not anaemic (>0.24 L/L). Differences between categories in proportion of samples positive for Ikeda type or mean Cq value were examined using χ(2) tests or analysis of variance, respectively. Of 1,022 samples containing amplifiable DNA, 916 (90%) were positive for T. orientalis and 789 (77%) were positive for Ikeda type. Nucleotide sequencing of MPSP amplicons also identified the presence of Chitose and Buffeli types in 11 samples without Ikeda. Ikeda was detected in a greater proportion of severely anaemic (288/302; 95%) than mildly anaemic (227/252; 90%) cattle (p=0.02). In non-anaemic cattle, 344/406 (85%) were positive for T. orientalis and 247/406 (60%) were positive for Ikeda type. In samples from cattle that were piroplasm-positive, a greater proportion of anaemic (483/505, 96%) than non-anaemic (211/307; 69%) cattle were positive for Ikeda type (p<0.001). In piroplasm-negative cattle, 20/37 (54%) anaemic and 25/78 (32%) non-anaemic cattle were Ikeda-positive (p<0.05). The distributions of Cq values

  13. Monitoring an epidemic of Theileria-associated bovine anaemia (Ikeda) in cattle herds in New Zealand.

    PubMed

    McFadden, A M J; Vink, D; Pulford, D J; Lawrence, K; Gias, E; Heath, A C G; McFadden, C B; Bingham, P

    2016-03-01

    Monitoring an epidemic of an emerging vector-borne disease can be problematic; particularly in a country where vector-borne disease has previously had minimal impact on livestock. This paper describes methods of past and current surveillance of the Theileria-associated bovine anaemia (Ikeda; TABA) epidemic in New Zealand, and the resulting inferences made. Over the three year period of the TABA epidemic a portfolio of surveillance methods has been used: case reporting (with subsidised PCR testing), syndromic surveillance, sentinel surveillance, testing convenience samples for herd infection, as well as specific active surveillance initiatives to understand the tick vector distribution. Surveillance data have shown that the number of affected cattle herds has continued to increase over time with seasonal peaks in spring and autumn coinciding with peak activity of nymph and adult ticks respectively. In spring 2014, the epidemic extended south into areas that were previously considered to be unsuitable for the tick vector. As a result a survey was initiated that showed that ticks were present in areas outside of the known distribution. Testing pooled blood samples from cattle herds across New Zealand showed there still remained a significant percentage of herds where only non-Ikeda type infections were present, indicating that these herds were at risk of future TABA (Ikeda) outbreaks. For some regions there had been a noticeable increase in the percentage of herds infected, yet with only a small increase in the number of outbreaks compared with the previous year. Thus, outbreaks had either gone unobserved or had not been confirmed by testing. In these regions extensive low-input beef farming could explain the non-detection observed. There was a close relationship between the number of syndromic reports of anaemia and the number of confirmed cases of TABA (Ikeda), (P<0.01, adjusted R-squared=0.74). Active monitoring of the epidemic for a three year period has provided

  14. Ikeda-like chaos on a dynamically filtered supercontinuum light source

    NASA Astrophysics Data System (ADS)

    Chembo, Yanne K.; Jacquot, Maxime; Dudley, John M.; Larger, Laurent

    2016-08-01

    We demonstrate temporal chaos in a color-selection mechanism from the visible spectrum of a supercontinuum light source. The color-selection mechanism is governed by an acousto-optoelectronic nonlinear delayed-feedback scheme modeled by an Ikeda-like equation. Initially motivated by the design of a broad audience live demonstrator in the framework of the International Year of Light 2015, the setup also provides a different experimental tool to investigate the dynamical complexity of delayed-feedback dynamics. Deterministic hyperchaos is analyzed here from the experimental time series. A projection method identifies the delay parameter, for which the chaotic strange attractor originally evolving in an infinite-dimensional phase space can be revealed in a two-dimensional subspace.

  15. Epidemiology of the epidemic of bovine anaemia associated with Theileria orientalis (Ikeda) between August 2012 and March 2014.

    PubMed

    Lawrence, K; McFadden, Amj; Gias, E; Pulford, D J; Pomroy, W E

    2016-01-01

    To describe the epidemiology of the epidemic of bovine anaemia associated with Theileria orientalis infection (TABA) in New Zealand between 30 August 2012 and 4 March 2014. Blood samples and associated data were obtained from cases of TABA. The case definition for TABA was met when piroplasms were present on blood smears and the haematocrit was ≤0.24 L/L. Samples were analysed using quantitative PCR (qPCR) assays for the detection of T. orientalis Ikeda type. Only cases that were positive in the qPCR assays were included in the analysis. A case herd was defined as a herd that had ≥1 animal positive for T. orientalis Ikeda. Movement records for farms were accessed through the national animal identification and tracing scheme. The OR for cattle movements onto a case farm compared to a non-case farm was estimated using a generalised estimating equation model and the geodesic distance for movements onto case and non-case farms compared using Student's t-test. The kernel-smoothed risk of disease at the farm level was calculated using an extraction map and the clustering of diseased farms in time and space was measured using the spatial temporal inhomogeneous pair correlation function. In the first 18 months there were 496 case herds; 392 (79%) were dairy and 104 (21%) beef herds. Of 882 individual cases, 820 (93.0%) were positive for T. orientalis Ikeda in the qPCR assays. Case herds were initially clustered in the Northland, then the Waikato regions. The OR for a case farm compared to a non-case farm having ≥1 inward cattle movements was 2.03 (95% CI=1.52-2.71) and the distance moved was 26 (95% CI=20.8-31.3) km greater for case farms. The risk of disease was highest in a north, north-eastern to south, south-western belt across the Waikato region. The spatial-temporal analysis showed significant clustering of infected herds within 20-30 days and up to 15 km distant from a case farm. Theileria orientalis Ikeda type is likely to have been introduced into

  16. Clinical haematology and biochemistry profiles of cattle naturally infected with Theileria orientalis Ikeda type in New Zealand.

    PubMed

    Lawrence, K E; Forsyth, S F; Vaatstra, B L; McFadden, Amj; Pulford, D J; Govindaraju, K; Pomroy, W E

    2018-01-01

    To present the haematology and biochemistry profiles for cattle in New Zealand naturally infected with Theileria orientalis Ikeda type and investigate if the results differed between adult dairy cattle and calves aged <6 months. Haematology and biochemistry results were obtained from blood samples from cattle which tested positive for T. orientalis Ikeda type by PCR, that were submitted to veterinary laboratories in New Zealand between October 2012 and November 2014. Data sets for haematology and biochemistry results were prepared for adult dairy cattle (n=62 and 28, respectively) and calves aged <6 months (n=62 and 28, respectively), which were matched on the basis of individual haematocrit (HCT). Results were compared between age groups when categorised by HCT. Selected variables were plotted against individual HCT, and locally weighted scatterplot smoothing (Loess) curves were fitted to the data for adult dairy cattle and calves <6 months old. When categorised by HCT, the proportion of samples with HCT <0.15 L/L (severe anaemia) was greater for adult dairy cattle than for beef or dairy calves, for both haematology (p<0.002) and biochemistry (p<0.001) submissions. There were differences (p<0.05) between adult dairy cattle and calves aged <6 months in the relationships between HCT and red blood cell counts, mean corpuscular volume, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentrations, lymphocyte and eosinophil counts, and activities of glutamate dehydrogenase and aspartate aminotransferase. In both age groups anisocytosis was frequently recorded. The proportion of blood smears showing mild and moderate macrocytosis was greater in adults than calves (p=0.01), and mild and moderate poikilocytosis was greater in calves than adults (p=0.005). The haematology and biochemistry changes observed in cattle infected with T. orientalis Ikeda type were consistent with extravascular haemolytic anaemia. Adult dairy cattle were more likely to be severely

  17. Chaos based video encryption using maps and Ikeda time delay system

    NASA Astrophysics Data System (ADS)

    Valli, D.; Ganesan, K.

    2017-12-01

    Chaos based cryptosystems are an efficient method to deal with improved speed and highly secured multimedia encryption because of its elegant features, such as randomness, mixing, ergodicity, sensitivity to initial conditions and control parameters. In this paper, two chaos based cryptosystems are proposed: one is the higher-dimensional 12D chaotic map and the other is based on the Ikeda delay differential equation (DDE) suitable for designing a real-time secure symmetric video encryption scheme. These encryption schemes employ a substitution box (S-box) to diffuse the relationship between pixels of plain video and cipher video along with the diffusion of current input pixel with the previous cipher pixel, called cipher block chaining (CBC). The proposed method enhances the robustness against statistical, differential and chosen/known plain text attacks. Detailed analysis is carried out in this paper to demonstrate the security and uniqueness of the proposed scheme.

  18. Cluster analysis of the clinical histories of cattle affected with bovine anaemia associated with Theileria orientalis Ikeda type infection.

    PubMed

    Lawrence, K E; Forsyth, S F; Vaatstra, B L; McFadden, Amj; Pulford, D J; Govindaraju, K; Pomroy, W E

    2017-11-01

    AIM To determine the most commonly used words in the clinical histories of animals naturally infected with Theileria orientalis Ikeda type; whether these words differed between cases categorised by age, farm type or haematocrit (HCT), and if there was any clustering of the common words in relation to these categories. METHODS Clinical histories were transcribed for 605 cases of bovine anaemia associated with T. orientalis (TABA), that were submitted to laboratories with blood samples which tested positive for T. orientalis Ikeda type infection by PCR analysis, between October 2012 and November 2014. χ 2 tests were used to determine whether the proportion of submissions for each word was similar across the categories of HCT (normal, moderate anaemia or severe anaemia), farm type (dairy or beef) and age (young or old). Correspondence analysis (CA) was carried out on a contingency table of the frequency of the 28 most commonly used history words, cross-tabulated by age categories (young, old or unknown). Agglomerative hierarchical clustering, using Ward's method, was then performed on the coordinates from the correspondence analysis. RESULTS The six most commonly used history words were jaundice (204/605), lethargic (162/605), pale mucous membranes (161/605), cow (151/605), anaemia (147/605), and off milk (115/605). The proportion of cases with some history words differed between categories of age, farm type and HCT. The cluster analysis indicated that the recorded history words were grouped in two main clusters. The first included the words weight loss, tachycardia, pale mucous membranes, anaemia, lethargic and thin, and was associated with adult (p<0.001), severe anaemia (p<0.001) and dairy (p<0.001). The second cluster included the words deaths, ill-thrift, calves, calf and diarrhoea, and was associated with young (p<0.001), normal HCT (p<0.001), beef (p<0.001) and moderate anaemia (p<0.001). CONCLUSIONS AND CLINICAL RELEVANCE Cluster analysis of words recorded in

  19. Interaction between Liénard and Ikeda dynamics in a nonlinear electro-optical oscillator with delayed bandpass feedback.

    PubMed

    Marquez, Bicky A; Larger, Laurent; Brunner, Daniel; Chembo, Yanne K; Jacquot, Maxime

    2016-12-01

    We report on experimental and theoretical analysis of the complex dynamics generated by a nonlinear time-delayed electro-optic bandpass oscillator. We investigate the interaction between the slow- and fast-scale dynamics of autonomous oscillations in the breather regime. We analyze in detail the coupling between the fast-scale behavior associated to a characteristic low-pass Ikeda behavior and the slow-scale dynamics associated to a Liénard limit-cycle. Finally, we show that when projected onto a two-dimensional phase space, the attractors corresponding to periodic and chaotic breathers display a spiral-like pattern, which strongly depends on the shape of the nonlinear function.

  20. The Meaning of Relationships for Student Agency in Soka Education: Exploring the Lived Experiences and Application of Daisaku Ikeda's Value-Creating Philosophy through Narrative Inquiry

    ERIC Educational Resources Information Center

    Nagashima, Julie Takako

    2016-01-01

    This dissertation examines a pedagogy called Soka education that was founded in early 20th century Japan. Specifically, this dissertation offers an empirical and conceptual study that examines the application of Soka education in present day. After examining the historical and political context of Soka education, I explicate on Ikeda's (1928- )…

  1. Orientia tsutsugamushi Strain Ikeda Ankyrin Repeat-Containing Proteins Recruit SCF1 Ubiquitin Ligase Machinery via Poxvirus-Like F-Box Motifs.

    PubMed

    Beyer, Andrea R; VieBrock, Lauren; Rodino, Kyle G; Miller, Daniel P; Tegels, Brittney K; Marconi, Richard T; Carlyon, Jason A

    2015-10-01

    A rising theme among intracellular microbes is the delivery of ankyrin repeat-containing effectors (Anks) that interact with target proteins to co-opt host cell functions. Orientia tsutsugamushi, an obligate intracellular bacterium and the etiologic agent of scrub typhus, encodes one of the largest Ank repertoires of any sequenced microorganism. They have been previously identified as type 1 secretion system substrates. Here, in silico and manual sequence analyses revealed that a large proportion of O. tsutsugamushi strain Ikeda Anks bear a eukaryotic/poxvirus-like F-box motif, which is known to recruit host cell SCF1 ubiquitin ligase machinery. We assessed the Anks for the ability to serve as F-box proteins. Coimmunoprecipitation assays demonstrated that F-box-containing Anks interact with overexpressed and/or endogenous SCF1 components. When coexpressed with FLAG-Ank4_01 or FLAG-Ank9, a glutathione S-transferase (GST)-tagged version of the SCF1 component SKP1 localized to subcellular sites of FLAG-Ank accumulation. The abilities of recombinant Anks to interact and colocalize with SKP1 were F-box dependent. GST-SKP1 precipitated O. tsutsugamushi-derived Ank9 from infected host cells, verifying both that the pathogen expresses Ank9 during infection and the protein's capability to bind SKP1. Aligning O. tsutsugamushi, poxviral, and eukaryotic F-box sequences delineated three F-box residues that are highly conserved and likely to be functionally important. Substitution of these residues ablated the ability of GFP-Ank9 to interact with GST-SKP1. These results demonstrate that O. tsutsugamushi strain Ikeda Anks can co-opt host cell polyubiquitination machinery, provide the first evidence that an O. tsutsugamushi Ank does so during infection, and advance overall understanding of microbial F-box proteins. Ankyrin repeat-containing proteins (Anks) are important virulence factors of intracellular bacteria that mediate protein-protein interactions with host cell targets

  2. Orientia tsutsugamushi Strain Ikeda Ankyrin Repeat-Containing Proteins Recruit SCF1 Ubiquitin Ligase Machinery via Poxvirus-Like F-Box Motifs

    PubMed Central

    Beyer, Andrea R.; VieBrock, Lauren; Rodino, Kyle G.; Miller, Daniel P.; Tegels, Brittney K.; Marconi, Richard T.

    2015-01-01

    ABSTRACT A rising theme among intracellular microbes is the delivery of ankyrin repeat-containing effectors (Anks) that interact with target proteins to co-opt host cell functions. Orientia tsutsugamushi, an obligate intracellular bacterium and the etiologic agent of scrub typhus, encodes one of the largest Ank repertoires of any sequenced microorganism. They have been previously identified as type 1 secretion system substrates. Here, in silico and manual sequence analyses revealed that a large proportion of O. tsutsugamushi strain Ikeda Anks bear a eukaryotic/poxvirus-like F-box motif, which is known to recruit host cell SCF1 ubiquitin ligase machinery. We assessed the Anks for the ability to serve as F-box proteins. Coimmunoprecipitation assays demonstrated that F-box-containing Anks interact with overexpressed and/or endogenous SCF1 components. When coexpressed with FLAG-Ank4_01 or FLAG-Ank9, a glutathione S-transferase (GST)-tagged version of the SCF1 component SKP1 localized to subcellular sites of FLAG-Ank accumulation. The abilities of recombinant Anks to interact and colocalize with SKP1 were F-box dependent. GST-SKP1 precipitated O. tsutsugamushi-derived Ank9 from infected host cells, verifying both that the pathogen expresses Ank9 during infection and the protein's capability to bind SKP1. Aligning O. tsutsugamushi, poxviral, and eukaryotic F-box sequences delineated three F-box residues that are highly conserved and likely to be functionally important. Substitution of these residues ablated the ability of GFP-Ank9 to interact with GST-SKP1. These results demonstrate that O. tsutsugamushi strain Ikeda Anks can co-opt host cell polyubiquitination machinery, provide the first evidence that an O. tsutsugamushi Ank does so during infection, and advance overall understanding of microbial F-box proteins. IMPORTANCE Ankyrin repeat-containing proteins (Anks) are important virulence factors of intracellular bacteria that mediate protein-protein interactions with

  3. Biocompatible Adhesives

    DTIC Science & Technology

    1991-03-01

    gram of —> Triton X-405 (70%) and 0.5 gram sodium lauryl sulfate . After a nitrogen -3- /- „, y-iu/iouitj Cod*s Avail and/oh ’t , • Special...period of several hours and d) using a redox system comprising of additional persulfate and a reducing agent such as sodium bisulfite or sodium

  4. Semicrystalline Ferroelectric Fluoropolymers and Process for Preparing Same

    DTIC Science & Technology

    2000-12-05

    Furukawa, and N. Seo, Japanese Journal of Applied Physics, 29, 675, 1990], crystallization under high pressure [T. Yuki, S. Ito, T. Koda , and S. Ikeda...8217 Macromoiecules, 21, 2463 (1988), and 23, 3. B. Daudin, and M. Dubus, J. Appl. Phys., 62,994(1987). 4. T. Yuki, S. Ito, T. Koda , and S. Ikeda, Jpn. J. Appl...Fimilrawa and N. Sen. Jpn. J. Appl. Phvs., 29, 675 (1990). 21. T. Yuki, S. Ito, T. Koda , and S. Ikeda, Jpn. J. Appl. Phvs., 37, 5372 (1998). 22. S. Ikeda

  5. The Role of Peripheral Nerve Function in Age-Related Bone Loss and Changes in Bone Adaptation

    DTIC Science & Technology

    2015-12-01

    scratch response in development of spontaneous dermatitis in NC/Nga mice. Br J Dermatol 2004;151:335-45. 32. Nakano T, Andoh T, Sasaki A, Nojima H, Kuraishi... contact a stripe of brain derived neurotrophic factor becomes the axon [16]. During neuron growth, mitochondria, membrane vesicles, proteins involved in...epiphyseal bone marrow [27]. The CGRP containing neurons in rat femurs near the growth plate come in contact with osteoclasts [21]. Neuropeptide

  6. AltitudeOmics: The Basic Biology of Human Acclimatization to High Altitude

    DTIC Science & Technology

    2013-09-01

    News Physiol Sci 17: 17–21, 2002. 62. Willie CK, Macleod DB, Shaw AD, Smith KJ, Tzeng YC, Eves ND, Ikeda K, Graham J, Lewis NC, Day TA, Ainslie PN...transcranial magnetic stimulation. J Physiol 551, 661-671. Willie, C. K., Macleod, D. B., Shaw , A. D., Smith, K. J., Tzeng, Y. C., Eves, N. D., Ikeda...blood flow. Davis, Philadelphia. Willie CK, Macleod DB, Shaw AD, Smith KJ, Tzeng YC, Eves ND, Ikeda K, Graham J, Lewis NC, Day TA & Ainslie PN

  7. Prevalence of Theileria orientalis types in beef cattle herds on the North Coast of New South Wales.

    PubMed

    Proctor, Akk; Ball, M; Freeman, P; Jenkins, C; Bogema, D R

    2016-04-01

    To estimate the prevalence of Theileria orientalis infection for Chitose, Ikeda and Buffeli major piroplasm surface protein (MPSP) types at a herd- and animal-level in beef cattle in the North Coast Livestock Health and Pest Authority (NCLHPA) region of New South Wales (NSW). A total of 24 beef herds in the NCLHPA region containing more than 100 cattle were randomly selected. Blood samples were collected from five animals per herd and tested using Theileria PCR for Chitose, Buffeli and Ikeda. Samples were only taken from female cattle older than 2 years, born in the NCLHPA region and apparently healthy at the time of testing. The herd-level prevalence for all MPSP types (Chitose, Ikeda and Buffeli) was 100%, with a 95% confidence interval of 86.3-99.9%. The mean prevalence at an animal level was 83.3%, 92.5% and 95.0% for Theileria Chitose, Buffeli and Ikeda, respectively. Quantitative PCR testing showed that 81.9% of animals had a low-level infection, while 17.0% had a moderate level of infection, and only 1.0% had a high level of infection. The majority of animals had a mixed infection of two or three MPSP types and few animals showed single infection. The results indicate endemicity of T. orientalis, especially the Ikeda type, in the NCLHPA region of Australia. © 2016 Australian Veterinary Association.

  8. Optical Tuning of the Reflection of Azobenzene Liquid Crystal Doped Cholesterics (Preprint)

    DTIC Science & Technology

    2007-04-01

    RG 6. AUTHOR(S) Uladzimir A . Hrozhyk, Svetlana V . Serak, and Nelson V . Tabiryan (Beam Engineering for Advanced Measurements Corporation) Timothy...Reflection of Azobenzene Liquid Crystal Doped Cholesterics** By Uladzimir A . Hrozhyk, Svetlana V Serak, Nelson V . Tabil)lall * and Timothy 1. Bunning...1249. [5] T. Ikeda, O. Tsutsumi, Science 1995, 268, 1873. [6] T. Ikeda, J Mat. Chern. 2003, 13, 2037. [7] A . Urbas, J. Klosterman, V . Tondiglia, L

  9. Development of Liposome Encapsulated Hemoglobin (LEH) and Studies of Hemorrhagic Shock by Use of Imaging Studies with Oxygen-15 and Other Radiotracers

    DTIC Science & Technology

    2004-09-01

    hemoglobin in the oxy-hemoglobin state [Stratton 1988; Takeoka 1997]. 3) Decreased Vasoactivity. Because LEH has physical properties closer to red cells...in rabbit arterial segments. J Appl Physiol 82:1826-1835. [21] Sakai H, Horinouchi H, Masada Y, Takeoka S, Ikeda E, Takaori M, Kobayashi K and...4317-4325. [22] Sakai H, Horinouchi H, Tomiyama K, Ikeda E, Takeoka S, Kobayashi K and Tsuchida E (2001) Hemoglobin-vesicles as oxygen carriers

  10. Surface Characterization and Direct Bioelectrocatalysis of Multicopper Oxidases (POSTPRINT)

    DTIC Science & Technology

    2010-01-01

    4620. [29] M. Tarasevich, V. Bogdanovskaya, A. Kapustin, Electrochem. Commun. 5 (2003) 491. [30] S. Tsujimura , Y. Kamitaka, K. Kano, Fuel Cells 7 (2007...463. [31] S. Tsujimura , K. Kano, T. Ikeda, J. Electroanal. Chem. 576 (2005) 113. [32] S. Varfolomeev, I. Kurochkin, A. Yaropolov, Biosens...L. Rulisek, E. Solomon, U. Ryde, Inorg. Chem. 44 (2005) 5612. [42] S. Tsujimura , H. Tatsumi, J. Ogawa, S. Shimizu, K. Kano, T. Ikeda, J. Electroanal

  11. Relationship between the three kinds of healthy habits and the metabolic syndrome.

    PubMed

    Wada, Takashi; Fukumoto, Tsutomu; Ito, Kyoko; Hasegawa, Yasutaka; Osaki, Takanobu

    2009-08-01

    In 2005, the diagnostic criteria for Japan-specific metabolic syndrome were published. The representative health habits are Breslow's seven healthy practices, Morimoto's eight items and Ikeda's six healthy habits. We investigated the prevalence of metabolic syndrome related with life-style strongly among these three sets of healthy habit. Cross-sectional study was conducted for the prevalence of metabolic syndrome by practicing these healthy habits. 20,776 Japanese individuals visited the Health Science Center at Jikei University Hospital in Japan for medical check-ups. Subjects were divided into 8 groups based on gender and age (females in their 30s, 40s, 50s and 60s, and males in their 30s, 40s, 50s and 60s). Participants completed a simple, self-administered lifestyle questionnaire based on the three sets of healthy habits. Subjects were divided into three groups (poor, moderate and favorable) according to each of the healthy habit criteria. Significant differences were observed among 10 groups for Breslow's seven healthy practices, 4 groups for Morimoto's eight items, and 13 groups for Ikeda's six healthy habits. Ikeda's six healthy habits showed the most significant differences among the three sets of habits. Among the three methods tested, to practice more Ikeda's healthy habits were the most useful for metabolic syndrome. © 2009 Asian Oceanian Association for the Study of Obesity . Published by Elsevier Ltd. All rights reserved.

  12. Fundamental Principles of Coherent-Feedback Quantum Control

    DTIC Science & Technology

    2014-12-08

    in metrology (acceleration sensing, vibrometry, gravity wave detection) and in quantum information processing (continuous-variables quantum ...AFRL-OSR-VA-TR-2015-0009 FUNDAMENTAL PRINCIPLES OF COHERENT-FEEDBACK QUANTUM CONTROL Hideo Mabuchi LELAND STANFORD JUNIOR UNIV CA Final Report 12/08...foundations and potential applications of coherent-feedback quantum control. We have focused on potential applications in quantum -enhanced metrology and

  13. The Effects of Antioxidants and Experience on the Development of Age Dependent Cognitive Dysfunction and Neuropathology in Canines

    DTIC Science & Technology

    2001-10-01

    Douglas, H. Murphey, B.A. Muggenburg, S. Zicker , and N.W. Milgram. The effects of experience and antioxidants on size discrimination learning in the dog...submission: Appendix F. N.W. Milgram, S.C. Zicker , E. Head, B.A. Muggenburg, H. Murphey, C. Ikeda-Douglas, and C.W. Cotman. Dietary enrichment...dysfunction in canines N.W. Milgram,1* S.C. Zicker ,2 E. Head,3 B. A.Muggenburg,4 H. Murphey,4 C. Ikeda-Douglas’, and C.W. Cotman 3 ’Life Science Division

  14. Comparison of the performance of three PCR assays for the detection and differentiation of Theileria orientalis genotypes.

    PubMed

    Perera, Piyumali K; Gasser, Robin B; Pulford, David J; Stevenson, Mark A; Firestone, Simon M; McFadden, Andrew M J; Jabbar, Abdul

    2015-03-31

    Oriental theileriosis is a tick-borne disease of bovines caused by the members of the Theileria orientalis complex. Recently, we developed a multiplexed tandem (MT) PCR to detect, differentiate and quantitate four genotypes (i.e., buffeli, chitose, ikeda and type 5) of T. orientalis. In this study, we used MT PCR to assess the prevalence and infection intensity of four T. orientalis genotypes in selected cattle herds that experienced oriental theileriosis outbreaks in New Zealand, and compared the sensitivities and specificities of MT PCR, PCR-high resolution melting (PCR-HRM) and a TaqMan qPCR. MT PCR, PCR-HRM analysis for T. orientalis and a TaqMan qPCR assay for ikeda genotype were employed to test 154 and 88 cattle blood samples from North (where oriental theileriosis outbreaks had occurred; designated as Group 1) and South (where no outbreaks had been reported; Group 2) Islands of New Zealand, respectively. Quantitative data from MT PCR assay were analyzed using generalized linear model and paired-sample t-test. The diagnostic specificity and sensitivity of the assays were estimated using a Bayesian latent class modeling approach. In Group 1, 99.4% (153/154) of cattle were test-positive for T. orientalis in both the MT PCR and PCR-HRM assays. The apparent prevalences of genotype ikeda in Group 1 were 87.6% (134/153) and 87.7% (135/154) using the MT PCR and Ikeda TaqMan qPCR assays, respectively. Using the MT PCR test, all four genotypes of T. orientalis were detected. The infection intensity estimated for genotype ikeda was significantly higher (P = 0.009) in severely anaemic cattle than in those without anaemia, and this intensity was significantly higher than that of buffeli (P < 0.001) in the former cattle. Bayesian latent class analysis showed that the diagnostic sensitivities (97.1-98.9%) and specificities (96.5-98.9%) of the three PCR assays were very comparable. The present findings show the advantages of using the MT PCR assay as a useful tool

  15. Investigation of the index case herd and identification of the genotypes of Theileria orientalis associated with outbreaks of bovine anaemia in New Zealand in 2012.

    PubMed

    Pulford, D J; McFadden, Amj; Hamilton, J S; Donald, J

    2016-01-01

    On 7 September 2012 the Ministry for Primary Industries was notified of a dairy cow with regenerative anaemia (haematocrit (HCT) 0.08 L/L) in a herd of 465 Jersey-Friesian cross cows (index case herd) in the Northland region of New Zealand. Organisms consistent with Theileria spp. were present in red blood cells on a blood smear. No other causes of anaemia were detected following examination of affected cows. Blood samples collected from 29 randomly selected cows on 26 September 2012 showed that 24 (83%) were anaemic (HCT≤0.24 L/L) and therefore fitted the case definition for bovine anaemia associated with Theileria orientalis infection. Using a T. orientalis type-specific PCR assay that targeted the single subunit rRNA gene, all of six animals tested were positive for T. orientalis type Ikeda. Blood samples collected from clinically affected cattle in 11 subsequent outbreaks from throughout the North Island showed that T. orientalis Ikeda type was a common finding, but mixed infections with Chitose type were also identified. In addition, using a PCR assay that targeted the major piroplasm surface gene, T. orientalis type 5 was detected in one cow from the Waikato region. The presence of T. orientalis type Ikeda, as well as type 5, was confirmed in cattle from outbreaks of bovine anaemia in herds throughout the North Island of New Zealand. Two new types of T. orientalis were identified in this investigation, that were associated with a sudden rise in cases of bovine anaemia. The body of evidence showed that the Ikeda type was implicated as the cause of disease observed in this epidemic.

  16. A Study of Electrical and Optical Stability of GSZO THin Film Transisitors

    DTIC Science & Technology

    2014-01-01

    introduces an overview of the research carried out on IGZO , ZnO, and GSZO thin film transistors that is relevant to the work discussed in this...dangling bonds or electron trapping near the gate insulator interface in IGZO thin film transistors . Mathews et al. [13] indicated that subjecting TFTs to...Ping David Shieh, Hideo Hosono, and Jerzy Kanicki, Photofield-Effect in Amporphous In-Ga-Zn-O (a- IGZO ) Thin - Film Transistors . Journal of Information

  17. Investigation of bovine haemoplasmas and their association with anaemia in New Zealand cattle.

    PubMed

    McFadden, Amj; Ha, H J; Donald, J J; Bueno, I M; van Andel, M; Thompson, J C; Tisdall, D J; Pulford, D J

    2016-01-01

    A dairy cow, from a herd in the Waikato region of New Zealand, was reported with regenerative anaemia on 12 September 2014. Testing of blood from the animal using PCR assays for Theileria orientalis produced a negative result for both Chitose and Ikeda types. Using PCR and DNA sequencing, blood from the cow was positive for Candidatus Mycoplasma haemobos. Further testing of another 12 animals from the case herd, 27 days after the affected cow was first reported, showed 11 animals were positive for Candidatus M. haemobos or Mycoplasma wenyonii in the PCR. None of these cattle were clinically anaemic or positive for T. orientalis Ikeda type using PCR. A convenience sample of 47 blood samples from cattle throughout New Zealand, submitted to the Investigation and Diagnostic Centre (Ministry for Primary Industries) for surveillance testing for T. orientalis Ikeda, was selected for further testing for bovine haemoplasmas. Of these samples, 6/47 (13%) and 13/47(28%) were positive for M. wenyonii and Candidatus M. haemobos, respectively. There was no difference in the proportion of samples positive for the bovine haemaplasmas between cattle with anaemia that were negative for T. orientalis (6/20, 33%), or without anaemia or T. orientalis (10/18, 56%), or from cattle herds experiencing anaemia and infection with T. orientalis Ikeda type (3/9, 33%). Bovine haemoplasmosis. The presence of bovine haemoplasmas in blood does not establish causality for anaemia in cattle. Diagnosis of anaemia associated with haemoplasmosis would require exclusion of other causes of regenerative anaemia and an association of the agent with anaemia in affected cattle herds. The data collected in this study did not provide evidence that bovine haemoplasmas were associated with a large number of outbreaks of anaemia in cattle in New Zealand.

  18. IEEE International Semiconductor Laser Conference (14th) Held in Maui, Hawaii on September 19-23, 1994

    DTIC Science & Technology

    1994-09-23

    subcommittee chairs, Tom Koch, James Whiteaway and Yasuhiko Arakawa, for their efforts. The other Conference Committee members, Gary Evans, Joanne...Academy of Sciences, St. Petersburg, Russia Asia end Ausat/agla K. Ikeda Chair: Yasuhiko Arakawa Mitsubishi Electric Corporation, Hyogo, Japan University

  19. Dietary and Environmental Exposure to Cadmium and the Risk of Breast Cancer

    DTIC Science & Technology

    2011-10-01

    feeding history, oral contraceptive use or hormone replacement therapy. There was little difference between urinary Cd concentrations based on...Flemish adolescents and adults: associations and dose- response relationships. Environ Int, 2010, 36:330-7. Ikeda, M. , Moriguchi, J. , Ezaki, T

  20. Whole Adult Organism Transcriptional Profiling of Acute Metal Exposures in Male Zebrafish

    DTIC Science & Technology

    2014-03-10

    metabolism arginine & proline metabolism tyrosine metabolism glycine, serine & threonine metabolism tryptophan metabolism histidine metabolism nicotinate...gene locus - Associations with obesity indices in middle-aged women. Diabetes 2002, 51(4):1281–1286. 85. Inoue I, Shinoda Y, Ikeda M, Hayashi K

  1. Molecular characterisation of Theileria orientalis in imported and native bovines from Pakistan.

    PubMed

    Gebrekidan, Hagos; Abbas, Tariq; Wajid, Muhammad; Ali, Aamir; Gasser, Robin B; Jabbar, Abdul

    2017-01-01

    The epidemiological aspects of Theileria orientalis in Pakistan are unknown; therefore, investigations using sensitive and precise molecular techniques are required. This study reports the first molecular characterisation of T. orientalis detected from imported (Bos taurus) and native cattle (Bos indicus×Bos taurus) and buffaloes (Bubalus bubalis) selected from four districts of Punjab, Pakistan. DNA samples from blood (n=246) were extracted and tested using conventional PCR utilising the major piroplasm surface protein (MPSP) gene and multiplexed tandem PCR (MT-PCR). Theileria orientalis DNA was detected (15%; 22/147) only in imported cattle by conventional PCR, whereas 24.5% (36/147), 6% (3/50) and 6.1% (3/49) of the imported cattle and native Pakistani cattle and buffaloes, respectively were test-positive for T. orientalis using MT-PCR. Using MT-PCR, the prevalence of T. orientalis was significantly higher (P<0.0001) in imported cattle compared to that of detected in native Pakistani bovines. The prevalence of T. orientalis and DNA copies of chitose and ikeda were significantly higher (P<0.05) in imported cattle than those detected in native Pakistani bovines. DNA sequencing of amplicons of the conventional PCR revealed the presence of buffeli, chitose and ikeda genotypes of T. orientalis. Phylogenetic analysis revealed that the MPSP sequences of buffeli, chitose and ikeda from imported cattle were closely related to those sequences reported previously from Australia and other regions. This study provides the first survey of T. orientalis infection in imported and native bovines in Pakistan, and highlights the need for future studies to understand the spread of transboundary animal diseases. Copyright © 2016. Published by Elsevier B.V.

  2. Community-Based Research: Learning about Attitudes towards the Criminal Justice System

    ERIC Educational Resources Information Center

    Marche, Tammy A.; Briere, Jennifer L.

    2012-01-01

    Research points to the pedagogical value of an engaged and community service-learning approach to developing understanding of course content (Astin, Vogelgesang, Ikeda, & Yee, 2000). To help students achieve a better understanding of how the discipline of psychology contributes to the discipline of law, some students in a second year…

  3. Investigation of the Role of the Mitogenic Neuropeptide Galanin in Mammary Gland Development and Carcinogenesis

    DTIC Science & Technology

    2001-08-01

    mice completely inhibited lactation and resulted in the death of all pups within 24 hrs of birth (Table 1). S179D PRL treated mice displayed normal...42. Plaut, K., Ikeda, M. & Vonderhaar, B. K. (1993) Endocrinology 133, 1843-8. 43. Horseman , N. D., Zhao, W., Montecino-Rodriguez, E., Tanaka, M

  4. Discrimination and social anxiety disorder among African-Americans, Caribbean blacks, and non-Hispanic whites.

    PubMed

    Levine, Debra Siegel; Himle, Joseph A; Abelson, Jamie M; Matusko, Niki; Dhawan, Nikhil; Taylor, Robert Joseph

    2014-03-01

    The present study investigated the relationship between discrimination and social anxiety disorder (SAD) in a sample of African-Americans, Caribbean blacks, and non-Hispanic whites using the National Survey of American Life, the most comprehensive study of psychopathology among American blacks to date (N = 6082). Previous work has highlighted a strong association between discrimination and mental health symptoms (Keith, Lincoln, Taylor, and Jackson [Sex Roles 62:48-59, ]; Kessler, Mickelson, and Williams [J Health Soc Behav 40:208-230, 1999]; Soto, Dawson-Andoh, and BeLue [J Anxiety Disord 25:258-265, ]). However, few studies have examined the effects of particular types of discrimination on specific anxiety disorders or among different black subgroups. In this study, logistic regression analyses indicated that everyday but not major experiences of discrimination are associated with SAD for African-Americans, Caribbean blacks, and non-Hispanic whites. This study adds to the extant literature by demonstrating that specific types of discrimination may be uniquely associated with SAD for different ethnic/racial groups.

  5. A Moral Cosmopolitan Perspective on Language Education

    ERIC Educational Resources Information Center

    Obelleiro, Gonzalo

    2012-01-01

    In recent years, scholars have turned to cosmopolitanism as a framework for thinking through issues of language and citizenship. In this article, I present Daisaku Ikeda's philosophy of cosmopolitan education and compare it with others' in the extant literature. I examine, from a philosophical perspective, its roots in the Mahayana tradition of…

  6. All-Optical, Photonic Band Gap Modulation in Azobenzene Liquid Crystal Doped Cholesterics (Preprint)

    DTIC Science & Technology

    2006-10-01

    4348 5e. TASK NUMBER RG 6. AUTHOR(S) Uladzimir A . Hrozhyk, Svetlana V . Serak, and Nelson V . Tabiryan (Beam Engineering for Advanced Measurements...modulation in azobenzene liquid crystal doped cholesterics Uladzimir A . Hrozhyk, Svetlana v . Serak, Nelson V . Tabiryan Beam Engineeringfor Advanced...Tsutsumi, Science, 1995,268, 1873. [6] T. Ikeda, J Mat. Chern., 2003,13, 2037. [7] A . Urbas, J. Klosterman, V . Tondiglia, L. Natarajan, R

  7. Complete Genome Sequence of Methylobacterium populi P-1M, Isolated from Pink-Pigmented Household Biofilm.

    PubMed

    Morohoshi, Tomohiro; Ikeda, Tsukasa

    2016-06-16

    Methylobacterium populi P-1M is isolated from the pink-pigmented household biofilm. Here, we present the complete genome sequence of P-1M, consisting of one chromosome of 5,705,640 bp and five plasmids of 64,864 bp, 59,879 bp, 42,569 bp, 41,417 bp, and 29,506 bp. Copyright © 2016 Morohoshi and Ikeda.

  8. Quantization by Cosmic Background Radiation

    DTIC Science & Technology

    1989-05-01

    not use their results. However, in the last fifteen years many workers have realized the usefulness of the Kustaanheimo - Stiefel (K-S) transformation ...discussed by Ikeda and Miyachi in 1970 [19]. Five years earlier, Kustaanheimo and Stiefel had generalized the Levi-Civita tranformation and showed...perturbations are small and periodic in time, we might follow the advice of Kustaanheimo and Stiefel [251 and use the two-dimensional Levi- Civita

  9. Depth of Cure of New Flowable Composite Resins

    DTIC Science & Technology

    2012-03-30

    Flowable composites were introduced to the dental community in the late 1990’s (Ikeda, 2009; Bayne, 1998). The advantage of flowable composite-based...Depth of Cure of New Flowable Composite Resins A THESIS Presented to the Faculty of The Air Force Postgraduate Dental School...SCIENCE In Oral Biology By Inaam A. Pedalino, BS, DDS Dunn Dental Clinic Lackland AFB, TX 30 March 2012 Depth of Cure of New

  10. An outbreak of oriental theileriosis in dairy cattle imported to Vietnam from Australia.

    PubMed

    Gebrekidan, Hagos; Nelson, Linda; Smith, Greg; Gasser, Robin B; Jabbar, Abdul

    2017-05-01

    This study reports an outbreak of oriental theileriosis in dairy cattle imported to Vietnam from Australia. Following clinical and pathological diagnoses, a total of 112 cattle blood samples were divided into three groups and tested using multiplexed tandem PCR. Group 1 were from aborted heifers in Vietnam; group 2 were from cattle before shipment from group 1 cattle and group 3 were from the same batch of cattle but transported to Taiwan. Theileria orientalis DNA was detected in 72·3% cattle. The prevalences of T. orientalis in groups 1, 2 and 3 were 77·6, 86·9 and 57·5%, respectively, and the difference in prevalence was significant between groups 1 and 3 (P < 0·0001). The infection intensities of genotypes chitose and ikeda of T. orientalis were higher in groups 1 (57 721 and 33 709, respectively) and 3 (5897 and 61 766, respectively) than those in group 2 (2071 and 6331, respectively). Phylogenetic analyses of the major piroplasm surface protein sequences revealed that genotypes chitose and ikeda determined herein were closely related to those previously reported from Australia. This first report of an outbreak of oriental theileriosis in imported cattle emphasizes improved measures for the export and import of cattle infected with T. orientalis.

  11. Assessment of sequence variability in a p23 gene region within and among three genotypes of the Theileria orientalis complex from south-eastern Australia.

    PubMed

    Perera, Piyumali K; Gasser, Robin B; Jabbar, Abdul

    2015-03-01

    Oriental theileriosis is a tick-borne, protozoan disease of cattle caused by one or more genotypes of Theileria orientalis complex. In this study, we assessed sequence variability in a region of the 23kDa piroplasm membrane protein (p23) gene within and among three T. orientalis genotypes (designated buffeli, chitose and ikeda) in south-eastern Australia. Genomic DNA (n=100) was extracted from blood of infected cattle from various locations endemic for oriental theileriosis and tested by polymerase chain reaction (PCR)-coupled mutation scanning (single-strand conformation polymorphism (SSCP)) and targeted sequencing analysis. Eight distinct sequences represented all DNA samples, and three genotypes were found: buffeli (n=3), chitose (3) and ikeda (2). Nucleotide pairwise comparisons among these eight sequences revealed considerably higher variability among the genotypes (6.6-11.7%) than within them (0-1.9%), indicating that the p23 gene region allows the accurate identification of T. orientalis genotypes. In the future, we will combine this gene with other molecular markers to study the genetic structure of T. orientalis populations in Australasia, which will pave the way to establish a highly sensitive and specific PCR-based assay for genotypic diagnosis of infection and for assessing levels of parasitaemia in cattle. Copyright © 2014 Elsevier GmbH. All rights reserved.

  12. Overwintering Strategies of the Calanoid Copepod Calanus plumchrus in a Periodically Anoxic British Columbia Fjord.

    DTIC Science & Technology

    1982-10-01

    such as copepods, euphausids and pteropods in the water column (Sameoto, 1976; Hansen and Dunbar, 1971 ). When such organisms are concentrated in large...responsible for the acoustic volume reverberation he observed at 330 KHZ in the Western Pacific. Bary and Pieper ( 1971 ) working in Saanich Inlet, B.C...and chitin account for 8.5% of the total dry weight (Ikeda, 1972), the lipid analyses of Lee ( 1971 and 1974) would indicate that the total protein

  13. International Conference on Langmuir-Blodgett Films (5th) Held in Paris, France on 26-30 August 1991, Abstracts Booklet

    DTIC Science & Technology

    1991-08-01

    Fojihh LN.. aIsetiki, LA. Bazaheu*o, .Kaimx BP30 CI Photo-amplified stroget n y with Incorporation of non-amphiphilic compounds polyion complexed p...donor- films of N-acyl-p-nitroaniline and its acceptor organic compounds homologous amphiphile D. Zhu, C. Yang, Yu. Liu, Y. Xu Y..Mixamo, K, Kauiu, T...R. Kenn, H. MChwald, K. Kjaer, J. LB films of polyheterocyclic compounds with Als-Nielsen long alkyl chains HLNAkabam K. Fukuda, M. Ikeda, K

  14. Parameter-dependent behaviour of periodic channels in a locus of boundary crisis

    NASA Astrophysics Data System (ADS)

    Rankin, James; Osinga, Hinke M.

    2017-06-01

    A boundary crisis occurs when a chaotic attractor outgrows its basin of attraction and suddenly disappears. As previously reported, the locus of a boundary crisis is organised by homo- or heteroclinic tangencies between the stable and unstable manifolds of saddle periodic orbits. In two parameters, such tangencies lead to curves, but the locus of boundary crisis along those curves exhibits gaps or channels, in which other non-chaotic attractors persist. These attractors are stable periodic orbits which themselves can undergo a cascade of period-doubling bifurcations culminating in multi-component chaotic attractors. The canonical diffeomorphic two-dimensional Hénon map exhibits such periodic channels, which are structured in a particular ordered way: each channel is bounded on one side by a saddle-node bifurcation and on the other by a period-doubling cascade to chaos; furthermore, all channels seem to have the same orientation, with the saddle-node bifurcation always on the same side. We investigate the locus of boundary crisis in the Ikeda map, which models the dynamics of energy levels in a laser ring cavity. We find that the Ikeda map features periodic channels with a richer and more general organisation than for the Hénon map. Using numerical continuation, we investigate how the periodic channels depend on a third parameter and characterise how they split into multiple channels with different properties.

  15. Computing the Lyapunov spectrum of a dynamical system from an observed time series

    NASA Technical Reports Server (NTRS)

    Brown, Reggie; Bryant, Paul; Abarbanel, Henry D. I.

    1991-01-01

    The paper examines the problem of accurately determining, from an observed time series, the Liapunov exponents for the dynamical system generating the data. It is shown that, even with very large data sets, it is clearly advantageous to utilize local neighborhood-to-neighborhood mappings with higher-order Taylor series rather than just local linear maps. This procedure is demonstrated on the Henon and Ikeda maps of the plane itself, the Lorenz system of three ordinary differential equations, and the Mackey-Glass delay differential equation.

  16. Semiquantitative Multiplexed Tandem PCR for Detection and Differentiation of Four Theileria orientalis Genotypes in Cattle

    PubMed Central

    Perera, Piyumali K.; Gasser, Robin B.; Firestone, Simon M.; Smith, Lee; Roeber, Florian

    2014-01-01

    Oriental theileriosis is an emerging, tick-borne disease of bovines in the Asia-Pacific region and is caused by one or more genotypes of the Theileria orientalis complex. This study aimed to establish and validate a multiplexed tandem PCR (MT-PCR) assay using three distinct markers (major piroplasm surface protein, 23-kDa piroplasm membrane protein, and the first internal transcribed spacer of nuclear DNA), for the simultaneous detection and semiquantification of four genotypes (Buffeli, Chitose, Ikeda, and type 5) of the T. orientalis complex. Analytical specificity, analytical sensitivity, and repeatability of the established MT-PCR assay were assessed in a series of experiments. Subsequently, the assay was evaluated using 200 genomic DNA samples collected from cattle from farms on which oriental theileriosis outbreaks had occurred, and 110 samples from a region where no outbreaks had been reported. The results showed the MT-PCR assay specifically and reproducibly detected the expected genotypes (i.e., genotypes Buffeli, Chitose, Ikeda, and type 5) of the T. orientalis complex, reliably differentiated them, and was able to detect as little as 1 fg of genomic DNA from each genotype. The diagnostic specificity and sensitivity of the MT-PCR were estimated at 94.0% and 98.8%, respectively. The MT-PCR assay established here is a practical and effective diagnostic tool for the four main genotypes of T. orientalis complex in Australia and should assist studies of the epidemiology and pathophysiology of oriental theileriosis in the Asia-Pacific region. PMID:25339402

  17. Emergence of new types of Theileria orientalis in Australian cattle and possible cause of theileriosis outbreaks

    PubMed Central

    2011-01-01

    Theileria parasites cause a benign infection of cattle in parts of Australia where they are endemic, but have, in recent years, been suspected of being responsible for a number of outbreaks of disease in cattle near the coast of New South Wales. The objective of this study was to identify and characterize the species of Theileria in cattle on six farms in New South Wales where disease outbreaks have occurred, and compare with Theileria from three disease-free farms in Queensland that is endemic for Theileria. Special reference was made to sub-typing of T. orientalis by type-specific PCR and sequencing of the small subunit (SSU) rRNA gene, and sequence analysis of the gene encoding a polymorphic merozoite/piroplasm surface protein (MPSP) that may be under immune selection. Nucleotide sequencing of SSU rRNA and MPSP genes revealed the presence of four Theileria genotypes: T. orientalis (buffeli), T. orientalis (ikeda), T. orientalis (chitose) and T. orientalis type 4 (MPSP) or type C (SSU rRNA). The majority of animals showed mixed infections while a few showed single infection. When MPSP nucleotide sequences were translated into amino acids, base transition did not change amino acid composition of the protein product, suggesting possible silent polymorphism. The occurrence of ikeda and type 4 (type C) previously not reported to occur and silent mutation is thought to have enhanced parasite evasion of the host immune response causing the outbreak. PMID:21338493

  18. Molecular characterization of Theileria orientalis from cattle in Ethiopia.

    PubMed

    Gebrekidan, Hagos; Gasser, Robin B; Baneth, Gad; Yasur-Landau, Daniel; Nachum-Biala, Yaarit; Hailu, Asrat; Jabbar, Abdul

    2016-07-01

    This study reports the first molecular characterization of Theileria orientalis in local breeds of cattle in Ethiopia. A conventional PCR utilizing major piroplasm surface protein (MPSP) gene and an established multiplexed tandem PCR (MT-PCR) were used to characterize T. orientalis and to assess the infection intensity, respectively. Of 232 blood samples tested, T. orientalis DNA was detected in only 2.2% of samples using conventional PCR; two genotypes buffeli (1.3%; 3/232) and type 5 (0.9%; 2/232) of T. orientalis were detected. Phylogenetic analysis revealed that the buffeli MPSP sequences from Ethiopia were closely related to those reported from Kenya, Sri Lanka and Myanmar, and type 5 sequences from Ethiopia grouped with those from Korea, Japan, Vietnam and Thailand. A higher number of samples (3.9%; 9/232) were test-positive by MT-PCR and four genotypes (buffeli, chitose, ikeda and type 5) of T. orientalis were detected. The average intensity of infections with genotypes buffeli (DNA copy numbers 11,056) and type 5 (7508) were significantly higher (P<0.0001) than the pathogenic genotype ikeda (61 DNA copies). This first insight into T. orientalis from cattle in Ethiopia using MPSP gene provides a basis for future studies of T. orientalis in various agroclimatic zones and of the impact of oriental theilerosis on cattle in this and other countries of Africa. Copyright © 2016 Elsevier GmbH. All rights reserved.

  19. Significance of urinary hippuric acid determination as an index of toluene exposure

    PubMed Central

    Ikeda, Masayuki; Ohtsuji, Hatsue

    1969-01-01

    Ikeda, Masayuki, and Ohtsuji, Hatsue (1969).Brit. J. industr. Med.,26, 244-246. Significance of urinary hippuric acid determination as an index of toluene exposure. Urine samples from 118 male workers in photogravure printing factories were analysed for hippuric acid. The urinary levels of hippuric acid were proportional to the environmental concentrations of toluene, although within wide variations. The urinary concentration of hippuric acid corresponding to 200 p.p.m. of toluene was 3·5 g./litre (specific gravity 1·016) or 4·3 g./g. creatinine. PMID:5794951

  20. Effect of forward speed on the roll damping of three small fishing vessels

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Haddara, M.R.; Zhang, S.

    1994-05-01

    An extensive experimental program has been carried out to estimate roll damping parameters for three models of fishing vessels having different hull shapes and moving with forward speed. Roll damping parameters are determined using a novel method. This method combines the energy method and the modulating function method. The effect of forward speed, initial heel angle and the natural frequency on damping is discussed. A modification of Ikeda's formula for lift damping prediction is suggested. The modified formula produces results which are in good agreement with the experiments.

  1. Development and Validation of a Quantitative PCR Assay Using Multiplexed Hydrolysis Probes for Detection and Quantification of Theileria orientalis Isolates and Differentiation of Clinically Relevant Subtypes

    PubMed Central

    Bogema, D. R.; Deutscher, A. T.; Fell, S.; Collins, D.; Eamens, G. J.

    2015-01-01

    Theileria orientalis is an emerging pathogen of cattle in Asia, Australia, and New Zealand. This organism is a vector-borne hemoprotozoan that causes clinical disease characterized by anemia, abortion, and death, as well as persistent subclinical infections. Molecular methods of diagnosis are preferred due to their sensitivity and utility in differentiating between pathogenic and apathogenic genotypes. Conventional PCR (cPCR) assays for T. orientalis detection and typing are laborious and do not provide an estimate of parasite load. Current real-time PCR assays cannot differentiate between clinically relevant and benign genotypes or are only semiquantitative without a defined clinical threshold. Here, we developed and validated a hydrolysis probe quantitative PCR (qPCR) assay which universally detects and quantifies T. orientalis and identifies the clinically associated Ikeda and Chitose genotypes (UIC assay). Comparison of the UIC assay results with previously validated universal and genotype-specific cPCR results demonstrated that qPCR detects and differentiates T. orientalis with high sensitivity and specificiy. Comparison of quantitative results based on percent parasitemia, determined via blood film analysis and packed cell volume (PCV) revealed significant positive and negative correlations, respectively. One-way analysis of variance (ANOVA) indicated that blood samples from animals with clinical signs of disease contained statistically higher concentrations of T. orientalis DNA than animals with subclinical infections. We propose clinical thresholds to assist in classifying high-, moderate-, and low-level infections and describe how parasite load and the presence of the Ikeda and Chitose genotypes relate to disease. PMID:25588653

  2. Smectic phases in hard particle mixtures: Koda's theory

    NASA Astrophysics Data System (ADS)

    Vesely, Franz J.

    Mixtures of parallel linear particles and spheres tend to demix upon compression. The linear species usually concentrates in regular layers, thus forming a smectic phase. With increasing concentration of spheres this 'smectic demixing' transition occurs at ever lower packing densities. For the specific case of hard spherocylinders and spheres Koda et al. [T. Koda, M. Numajiri, S. Ikeda, J. Phys. Jap., 65, 3551 (1996)] have explained the layering effect in terms of a second virial approximation to the free energy. We extend this approach from spherocylinders to other linear particles, namely fused spheres, ellipsoids and sphero-ellipsoids.

  3. Shape-retainment control using an antagonistic shape memory alloy system

    NASA Astrophysics Data System (ADS)

    Ikeda, T.; Sawamura, K.; Senba, A.; Tamayama, M.

    2015-04-01

    Since shape memory alloy (SMA) actuators can generate large force per unit weight, they are expected as one of the next generation actuators for aircraft. To keep a position of conventional control surfaces or morphing wings with SMA actuators, the SMA actuators must keep being heated, and the heating energy is not small. To save the energy, a new control method proposed for piezoelectric actuators utilizing hysteresis in deformation [Ikeda and Takahashi, Proc. SPIE 8689 (2013), 86890C] is applied to an antagonistic SMA system. By using the control method any position can be an equilibrium point within hysteresis of stress-strain diagrams. To confirm a feasibility of the control method, a fundamental experiment is performed. The SMA wires are heated by applying electric current to the wires. When a pulsed current is applied to the two SMA wires alternately, the equilibrium position changes between two positions alternately, and when a series of pulse whose amplitude increases gradually is applied to one SMA wire, the equilibrium position changes like a staircase. However, just after the pulse the position returns slightly, that is, overshoot takes place. To investigate such a behavior of the system, numerical simulation is also performed. The one-dimensional phase transformation model [Ikeda, Proc. SPIE 5757 (2005), 344-352] is used for a constitutive model of the SMA wires. The simulated result agrees with the experiment qualitatively, including the overshoot. By examining volume fraction of each phase, it is found that the overshoot is caused by that austenite phase transforms into stress-induced martensite phase during the cooling process after the pulse.

  4. The origins of scientific psychology in Japan.

    PubMed

    Takasuna, Miki

    2006-01-01

    The origins of scientific psychology in Japan arrived primarily through six routes. First, psychology was imported through translations by Amane Nishi, which resulted in the coining of words such as "psychology," "subject," and "object." Second, psychology arrived in the form of education that was directed by American Christian missionaries. The third route brought psychology through lectures presented at universities (e.g., Masakazu Toyama began lecturing at the University of Tokyo in 1877). The fourth route relates to teacher education: Shuji Izawa and Hideo Takamine introduced psychology as part of the first curriculum at Tokyo Higher Normal School in 1879. The fifth route was created by Japanese philosophers who studied abroad, such as Tetsujiro Inouye. Finally, the sixth and most important avenue involved the introduction of experimental psychology, as well as a formal educational curriculum for psychologists (e.g., Yujiro Motora was the first Japanese to introduce experimental psychology to Japan, where he trained many students). Consequently, the establishment of scientific psychology in Japan was primarily owed to the Japanese scholars who studied abroad in the U.S. and Germany.

  5. Crystal Structures of Copper-depleted and Copper-bound Fungal Pro-tyrosinase

    PubMed Central

    Fujieda, Nobutaka; Yabuta, Shintaro; Ikeda, Takuya; Oyama, Takuji; Muraki, Norifumi; Kurisu, Genji; Itoh, Shinobu

    2013-01-01

    Tyrosinase, a dinuclear copper monooxygenase/oxidase, plays a crucial role in the melanin pigment biosynthesis. The structure and functions of tyrosinase have so far been studied extensively, but the post-translational maturation process from the pro-form to the active form has been less explored. In this study, we provide the crystal structures of Aspergillus oryzae full-length pro-tyrosinase in the holo- and the apo-forms at 1.39 and 2.05 Å resolution, respectively, revealing that Phe513 on the C-terminal domain is accommodated in the substrate-binding site as a substrate analog to protect the dicopper active site from substrate access (proteolytic cleavage of the C-terminal domain or deformation of the C-terminal domain by acid treatment transforms the pro-tyrosinase to the active enzyme (Fujieda, N., Murata, M., Yabuta, S., Ikeda, T., Shimokawa, C., Nakamura, Y., Hata, Y., and Itoh, S. (2012) ChemBioChem. 13, 193–201 and Fujieda, N., Murata, M., Yabuta, S., Ikeda, T., Shimokawa, C., Nakamura, Y., Hata, Yl, and Itoh, S. (2013) J. Biol. Inorg. Chem. 18, 19–26). Detailed crystallographic analysis and structure-based mutational studies have shown that the copper incorporation into the active site is governed by three cysteines as follows: Cys92, which is covalently bound to His94 via an unusual thioether linkage in the holo-form, and Cys522 and Cys525 of the CXXC motif located on the C-terminal domain. Molecular mechanisms of the maturation processes of fungal tyrosinase involving the accommodation of the dinuclear copper unit, the post-translational His-Cys thioether cross-linkage formation, and the proteolytic C-terminal cleavage to produce the active tyrosinase have been discussed on the basis of the detailed structural information. PMID:23749993

  6. Chaotic evolution of the long-period Milankovitch cycle during the early Mesozoic: independent evidences from the Newark lacustrine sequence (North America) and the pelagic bedded chert sequence (Japan)

    NASA Astrophysics Data System (ADS)

    Ikeda, M.; Olsen, P. E.; Tada, R.

    2012-12-01

    The correlation of Earth's orbital parameters with climatic variations has been used to generate astronomically calibrated geologic time scales of high accuracy. However, because of the chaotic behavior of the solar planets, the orbital models have a large uncertainty beyond several tens of million years in the past. This chaotic behavior also causes the long-period astronomical cycles (> 0.5 Myr periodicity) to modulate their frequency and amplitude. In other words, their modulation patterns could be potential constraints for the orbital models. Here we report the first geologic constraints on the timing of frequency transition and amplitude modulation of the ~ 2 Myr long eccentricity cycles during the early Mesozoic. We examined the lake level records of the early Mesozoic Newark lacustrine sequence in North America and the biogenic silica burial rate of the pelagic bedded chert sequence in the Inuyama area, Japan, which are proven to be reflect the astronomical cycle (Olsen, 1986; Olsen and Kent, 1996; Ikeda et al., 2010). The time scales of the two sequences were orbitally calibrated with the end-Triassic mass extinction interval as the age anchor, covering ~ 30 Myr and ~ 65 Myr, respectively (Olsen et al., 2011; Ikeda et al., 2010, in prep). We find that the frequency modulation of ~ 2 Myr cycle between 2.4 Myr to 1.6 Myr cycle have occurred at least the Middle to Late Triassic. In addition, the ~ 2 Myr cycle modulate its amplitude with ~ 10 Myr periodicity with in-phase relation between the two. Similar modulation patterns of ~ 2 Myr cycles from the two independent geologic records indicate convincing evidences for the chaotic behavior of the Solar planets. Because these modulation patterns are different from the results of the orbital models by Laskar et al. (2004, 2011), our records will provide the new and challenging constraints for the orbital models in terms of chaotic behavior of Solar planets.

  7. High-lying Gamow-Teller excited states in the deformed nuclei,76Ge,82Se and N = 20 nuclei in the island of inversion by the Deformed QRPA (DQRPA)

    NASA Astrophysics Data System (ADS)

    Cheoun, Myung-Ki; Ha, Eunja

    2013-07-01

    With the advent of high analysis technology in detecting the Gamow-Teller (GT) excited states beyond one nucleon emission threshold, the quenching of the GT strength to the Ikeda sum rule (ISR) seems to be recovered by the high-lying (HL) GT states. We address that these HL GT excited states result from the smearing of the Fermi surface by the increase of the chemical potential owing to the deformation within a framework of the deformed quasi-particle random phase approximation (DQRPA). Detailed mechanism leading to the smearing is discussed, and comparisons to the available experimental data on 76Ge,82Se and N = 20 nuclei are shown to explain the strong peaks on the HL GT excited states.

  8. Exact synchronization bound for coupled time-delay systems.

    PubMed

    Senthilkumar, D V; Pesquera, Luis; Banerjee, Santo; Ortín, Silvia; Kurths, J

    2013-04-01

    We obtain an exact bound for synchronization in coupled time-delay systems using the generalized Halanay inequality for the general case of time-dependent delay, coupling, and coefficients. Furthermore, we show that the same analysis is applicable to both uni- and bidirectionally coupled time-delay systems with an appropriate evolution equation for their synchronization manifold, which can also be defined for different types of synchronization. The exact synchronization bound assures an exponential stabilization of the synchronization manifold which is crucial for applications. The analytical synchronization bound is independent of the nature of the modulation and can be applied to any time-delay system satisfying a Lipschitz condition. The analytical results are corroborated numerically using the Ikeda system.

  9. Simulation of noisy dynamical system by Deep Learning

    NASA Astrophysics Data System (ADS)

    Yeo, Kyongmin

    2017-11-01

    Deep learning has attracted huge attention due to its powerful representation capability. However, most of the studies on deep learning have been focused on visual analytics or language modeling and the capability of the deep learning in modeling dynamical systems is not well understood. In this study, we use a recurrent neural network to model noisy nonlinear dynamical systems. In particular, we use a long short-term memory (LSTM) network, which constructs internal nonlinear dynamics systems. We propose a cross-entropy loss with spatial ridge regularization to learn a non-stationary conditional probability distribution from a noisy nonlinear dynamical system. A Monte Carlo procedure to perform time-marching simulations by using the LSTM is presented. The behavior of the LSTM is studied by using noisy, forced Van der Pol oscillator and Ikeda equation.

  10. Mannitol and Mannitol Dehydrogenases in Conidia of Aspergillus oryzae

    PubMed Central

    Horikoshi, Koki; Iida, Shigeji; Ikeda, Yonosuke

    1965-01-01

    Horikoshi, Koki (The Institute of Physical and Chemical Research, Tokyo, Japan), Shigeji Iida, and Yonosuke Ikeda. Mannitol and mannitol dehydrogenases in conidia of Aspergillus oryzae. J. Bacteriol. 89:326–330. 1965.—A sugar alcohol was isolated from the conidia of Aspergillus oryzae and identified as d-mannitol. Two types of d-mannitol dehydrogenases, nicotinamide adenine dinucleotide phosphate-linked and nicotinamide adenine dinucleotide-linked, were found in the conidia. Substrate specificities, pH optima, Michaelis-Menton constants, and the effects of inhibitors were studied. d-Mannitol was converted to fructose by the dehydrogenases. Synthesis of d-mannitol dehydrogenases was not observed during germination; the content of d-mannitol decreased at an early stage of germination. It was assumed, therefore, that d-mannitol might be used as the source of endogenous respiration and provide energy for the germination. PMID:14255698

  11. Modelling of c-C2H4O Formation on Grain-Surfaces

    NASA Astrophysics Data System (ADS)

    Occhiogrosso, Angela; Viti, S.; Ward, M. D.; Price, S. D.

    2013-01-01

    Ethylene oxide (c-C2H4O) is a ring-shaped organic compound that may lead to the synthesis of amino acids and the early metabolic pathways in the interstellar medium (ISM) (Cleaves 2003; Miller & Schlesinger 1993). This molecule has been detected towards several high-mass star forming regions (Ikeda et al. 2001) but to date, its observational abundances cannot be reproduced by chemical models. We include new experimental results in the UCL_CHEM chemical model with the aim of reproducing the abundances of ethylene oxide across high-mass sources. In particular, we focused on the solid state reaction investigated by Ward & Price (2011). By comparing our theoretical column densities with those from the observations we found that the reaction between atomic oxygen and ethylene on grains is a viable route of formation for ethylene oxide (Occhiogrosso et al., accepted by MNRAS).

  12. Three-dimensional drift kinetic response of high-β plasmas in the DIII-D tokamak.

    PubMed

    Wang, Z R; Lanctot, M J; Liu, Y Q; Park, J-K; Menard, J E

    2015-04-10

    A quantitative interpretation of the experimentally measured high-pressure plasma response to externally applied three-dimensional (3D) magnetic field perturbations, across the no-wall Troyon β limit, is achieved. The self-consistent inclusion of the drift kinetic effects in magnetohydrodynamic (MHD) modeling [Y. Q. Liu et al., Phys. Plasmas 15, 112503 (2008)] successfully resolves an outstanding issue of the ideal MHD model, which significantly overpredicts the plasma-induced field amplification near the no-wall limit, as compared to experiments. The model leads to quantitative agreement not only for the measured field amplitude and toroidal phase but also for the measured internal 3D displacement of the plasma. The results can be important to the prediction of the reliable plasma behavior in advanced fusion devices, such as ITER [K. Ikeda, Nucl. Fusion 47, S1 (2007)].

  13. Assessing the performance of multiplexed tandem PCR for the diagnosis of pathogenic genotypes of Theileria orientalis using pooled blood samples from cattle.

    PubMed

    Gebrekidan, Hagos; Gasser, Robin B; Stevenson, Mark A; McGrath, Sean; Jabbar, Abdul

    2017-02-01

    Oriental theileriosis caused by multiple genotypes of Theileria orientalis is an important tick-borne disease of bovines. Here, we assessed the performance of an established multiplexed tandem PCR (MT-PCR) for the diagnosis of the two recognized, pathogenic genotypes (chitose and ikeda) of T. orientalis in cattle using pooled blood samples. We used a total of 265 cattle blood samples, which were divided into two groups according to previous MT-PCR results for individual samples. Samples in group 1 (n = 155) were from a herd with a relatively high prevalence of T. orientalis infection; and those in group 2 (n = 110) were from four herds with a low prevalence. For group 1, 31 and 15 batches of five- and ten-pooled samples (selected at random), respectively, were formed. For group 2, 22 and 11 batches of five- and ten-pooled samples (selected at random), respectively, were formed. DNAs from individual pooled samples in each batch and group were then tested by MT-PCR. For group 1, the apparent prevalences estimated using the 31 batches of five-pooled samples (97%) and 15 batches of ten-pooled samples (100%) were significantly higher compared with individual samples (75%). For group 2, higher apparent prevalences (9% and 36%) were also recorded for the 22 and 11 batches of pooled samples, respectively, compared with individual samples (7%). Overall, the average infection intensity recorded for the genotypes of chitose and ikeda were considerably lower in pooled compared with individual samples. The diagnostic specificities of MT-PCR were estimated at 95% and 94%, respectively, when batches of five- and ten-pooled samples were tested, and 94% for individual samples. The diagnostic sensitivity of this assay was estimated at 98% same for all individual, five- and ten-pooled samples. This study shows that screening batches of five- and ten-pooled blood samples from cattle herds are similar to those obtained for individual samples, and, importantly, that the reduced cost

  14. Autosomal dominant cortical tremor, myoclonus and epilepsy.

    PubMed

    Striano, Pasquale; Zara, Federico

    2016-09-01

    The term 'cortical tremor' was first introduced by Ikeda and colleagues to indicate a postural and action-induced shivering movement of the hands which mimics essential tremor, but presents with the electrophysiological findings of cortical reflex myoclonus. The association between autosomal dominant cortical tremor, myoclonus and epilepsy (ADCME) was first recognized in Japanese families and is now increasingly reported worldwide, although it is described using different acronyms (BAFME, FAME, FEME, FCTE and others). The disease usually takes a benign course, although drug-resistant focal seizures or slight intellectual disability occur in some cases. Moreover, a worsening of cortical tremor and myoclonus is common in advanced age. Although not yet recognized by the International League Against Epilepsy (ILAE), this is a well-delineated epilepsy syndrome with remarkable features that clearly distinguishes it from other myoclonus epilepsies. Moreover, genetic studies of these families show heterogeneity and different susceptible chromosomal loci have been identified.

  15. Covalent Binding with Neutrons on the Femto-scale

    NASA Astrophysics Data System (ADS)

    von Oertzen, W.; Kanada-En'yo, Y.; Kimura, M.

    2017-06-01

    In light nuclei we have well defined clusters, nuclei with closed shells, which serve as centers for binary molecules with covalent binding by valence neutrons. Single neutron orbitals in light neutron-excess nuclei have well defined shell model quantum numbers. With the combination of two clusters and their neutron valence states, molecular two-center orbitals are defined; in the two-center shell model we can place valence neutrons in a large variety of molecular two-center states, and the formation of Dimers becomes possible. The corresponding rotational bands point with their large moments of inertia and the Coriolis decoupling effect (for K = 1/2 bands) to the internal molecular orbital structure in these states. On the basis of these the neutron rich isotopes allow the formation of a large variety molecular structures on the nuclear scale. An extended Ikeda diagram can be drawn for these cases. Molecular bands in Be and Ne-isotopes are discussed as text-book examples.

  16. Molecular epidemiology and genetic diversity of Orientia tsutsugamushi from patients with scrub typhus in 3 regions of India.

    PubMed

    Varghese, George M; Janardhanan, Jeshina; Mahajan, Sanjay K; Tariang, David; Trowbridge, Paul; Prakash, John A J; David, Thambu; Sathendra, Sowmya; Abraham, O C

    2015-01-01

    Scrub typhus, an acute febrile illness that is widespread in the Asia-Pacific region, is caused by the bacterium Orientia tsutsugamushi, which displays high levels of antigenic variation. We conducted an investigation to identify the circulating genotypes of O. tsutsugamushi in 3 scrub typhus-endemic geographic regions of India: South India, Northern India, and Northeast India. Eschar samples collected during September 2010-August 2012 from patients with scrub typhus were subjected to 56-kDa type-specific PCR and sequencing to identify their genotypes. Kato-like strains predominated (61.5%), especially in the South and Northeast, followed by Karp-like strains (27.7%) and Gilliam and Ikeda strains (2.3% each). Neimeng-65 genotype strains were also observed in the Northeast. Clarifying the genotypic diversity of O. tsutsugamushi in India enhances knowledge of the regional diversity among circulating strains and provides potential resources for future region-specific diagnostic studies and vaccine development.

  17. A Statement of Values for Our Research on Music in Peacebuilding: A Synthesis of Galtung and Ikeda's Peace Theories

    ERIC Educational Resources Information Center

    Urbain, Olivier

    2016-01-01

    Recent years have seen a growing interest in research linking musicking and peacebuilding, and the establishment of the Min-On Music Research Institute (MOMRI) in 2014 in Tokyo follows this trend. Its mission statement is: "To pursue a multidisciplinary investigation of the potential application of music in peacebuilding activities," in…

  18. Modified Hartree-Fock-Bogoliubov theory at finite temperature

    NASA Astrophysics Data System (ADS)

    Dinh Dang, Nguyen; Arima, Akito

    2003-07-01

    The modified Hartree-Fock-Bogoliubov (MHFB) theory at finite temperature is derived, which conserves the unitarity relation of the particle-density matrix. This is achieved by constructing a modified-quasiparticle-density matrix, where the fluctuation of the quasiparticle number is microscopically built in. This matrix can be directly obtained from the usual quasiparticle-density matrix by applying the secondary Bogoliubov transformation, which includes the quasiparticle-occupation number. It is shown that, in the limit of constant pairing parameter, the MHFB theory yields the previously obtained modified BCS (MBCS) equations. It is also proved that the modified quasiparticle-random-phase approximation, which is based on the MBCS quasiparticle excitations, conserves the Ikeda sum rule. The numerical calculations of the pairing gap, heat capacity, level density, and level-density parameter within the MBCS theory are carried out for 120Sn. The results show that the superfluid-normal phase transition is completely washed out. The applicability of the MBCS up to a temperature as high as T˜5 MeV is analyzed in detail.

  19. Designing the Alluvial Riverbeds in Curved Paths

    NASA Astrophysics Data System (ADS)

    Macura, Viliam; Škrinár, Andrej; Štefunková, Zuzana; Muchová, Zlatica; Majorošová, Martina

    2017-10-01

    The paper presents the method of determining the shape of the riverbed in curves of the watercourse, which is based on the method of Ikeda (1975) developed for a slightly curved path in sandy riverbed. Regulated rivers have essentially slightly and smoothly curved paths; therefore, this methodology provides the appropriate basis for river restoration. Based on the research in the experimental reach of the Holeška Brook and several alluvial mountain streams the methodology was adjusted. The method also takes into account other important characteristics of bottom material - the shape and orientation of the particles, settling velocity and drag coefficients. Thus, the method is mainly meant for the natural sand-gravel material, which is heterogeneous and the particle shape of the bottom material is very different from spherical. The calculation of the river channel in the curved path provides the basis for the design of optimal habitat, but also for the design of foundations of armouring of the bankside of the channel. The input data is adapted to the conditions of design practice.

  20. Projective-anticipating, projective, and projective-lag synchronization of time-delayed chaotic systems on random networks.

    PubMed

    Feng, Cun-Fang; Xu, Xin-Jian; Wang, Sheng-Jun; Wang, Ying-Hai

    2008-06-01

    We study projective-anticipating, projective, and projective-lag synchronization of time-delayed chaotic systems on random networks. We relax some limitations of previous work, where projective-anticipating and projective-lag synchronization can be achieved only on two coupled chaotic systems. In this paper, we realize projective-anticipating and projective-lag synchronization on complex dynamical networks composed of a large number of interconnected components. At the same time, although previous work studied projective synchronization on complex dynamical networks, the dynamics of the nodes are coupled partially linear chaotic systems. In this paper, the dynamics of the nodes of the complex networks are time-delayed chaotic systems without the limitation of the partial linearity. Based on the Lyapunov stability theory, we suggest a generic method to achieve the projective-anticipating, projective, and projective-lag synchronization of time-delayed chaotic systems on random dynamical networks, and we find both its existence and sufficient stability conditions. The validity of the proposed method is demonstrated and verified by examining specific examples using Ikeda and Mackey-Glass systems on Erdos-Renyi networks.

  1. UV light induced insulator-metal transition in ultra-thin ZnO/TiOx stacked layer grown by atomic layer deposition

    NASA Astrophysics Data System (ADS)

    Saha, D.; Misra, P.; Joshi, M. P.; Kukreja, L. M.

    2016-08-01

    In the present study, atomic layer deposition has been used to grow a series of Ti incorporated ZnO thin films by vertically stacking different numbers (n = 1-7) of ZnO/TiOx layers on (0001) sapphire substrates. The effects of defect states mediated chemisorption of O2 and/OH groups on the electrical properties of these films have been investigated by illuminating the samples under UV light inside a high vacuum optical cryostat. The ultra-thin film having one stacked layer (n = 1) did not show any change in its electrical resistance upon UV light exposure. On the contrary, marginal drop in the electrical resistivity was measured for the samples with n ≥ 3. Most surprisingly, the sample with n = 2 (thickness ˜ 12 nm) showed an insulator to metal transition upon UV light exposure. The temperature dependent electrical resistivity measurement on the as grown film (n = 2) showed insulating behaviour, i.e., diverging resistivity on extrapolation to T→ 0 K. However, upon UV light exposure, it transformed to a metallic state, i.e., finite resistivity at T → 0 K. Such an insulator-metal transition plausibly arises due to the de-trapping of conduction electrons from the surface defect sites which resulted in an upward shift of the Fermi level above the mobility edge. The low-temperature electron transport properties on the insulating film (n = 2) were investigated by a combined study of zero field electrical resistivity ρ(T) and magnetoresistance (MR) measurements. The observed negative MR was found to be in good agreement with the magnetic field induced suppression of quantum interference between forward-going paths of tunnelling electrons. Both ρ(T) and MR measurements provided strong evidence for the Efros-Shklovskii type variable range hopping conduction in the low-temperature (≤40 K) regime. Such studies on electron transport in ultra-thin n-type doped ZnO films are crucial to achieve optimum functionality with long term reliability of ZnO based transparent

  2. In vivo detection of fluctuating brain steroid levels SHORT

    PubMed Central

    Ikeda, Maaya; Rensel, Michelle A.; Schlinger, Barney A.; Remage-Healey, Luke

    2015-01-01

    This protocol describes a method for in vivo measurement of steroid hormones in brain circuits of the zebra finch. In vivo microdialysis has been used successfully to detect fluctuating neurosteroids in the auditory forebrain (Remage-Healey et al., 2008; 2012; Ikeda et al., 2012) and in the hippocampus (Rensel et al., 2012; 2013) of behaving adult zebra finches. In some cases, the steroids measured are derived locally (e.g., ‘neurosteroids’ like estrogens in males) whereas in other cases the steroids measured reflect systemic circulating levels and/or central conversion (e.g., the primary androgen testosterone and the primary glucocorticoid corticosterone). We also describe the method of reverse-microdialysis (‘retrodialysis’) of compounds that can influence local steroid neurochemistry as well as behavior. In vivo microdialysis can now be used to study steroid signaling in the brain for a variety of experimental purposes. Furthermore, similar methods have been developed to examine changing levels of catecholamines in behaving zebra finches (e.g., Sasaki et al., 2006). Thus, the combined study of neurochemistry and behavior in a vocal learning species now has a new set of powerful tools. PMID:25342066

  3. Astronomical large Ge immersion grating by Canon

    NASA Astrophysics Data System (ADS)

    Sukegawa, Takashi; Suzuki, Takeshi; Kitamura, Tsuyoshi

    2016-07-01

    Immersion grating is a powerful optical device for thee infrared high-resolution spectroscope. Germanium (GGe) is the best material for a mid-infrared immersion grating because of Ge has very large reflective index (n=4.0). On the other hands, there is no practical Ge immersion grating under 5umm use. It was very difficult for a fragile IR crystal to manufacture a diffraction grating precisely. Our original free-forming machine has accuracy of a few nano-meter in positioning and stability. We already fabricated the large CdZnTe immersion grating. (Sukegawa et al. (2012), Ikeda et al. (2015)) Wee are developing Ge immersion grating that can be a good solution for high-resolution infrared spectroscopy with the large ground-based/space telescopes. We succeeded practical Ge immersion grating with the grooved area off 75mm (ruled direction) x 119mm (grove width) and the blaze angle of 75 degrees. Our astronomical large Ge immersion grating has the grooved area of 155mm (ruled direction) x 41mmm (groove width) and groove pitch off 91.74um. We also report optical performance of astronomical large Ge immersion grating with a metal coating on the diffraction surface.

  4. The higher mode of surface wave derived from ambient noise and preliminary application to estimating subsurface

    NASA Astrophysics Data System (ADS)

    Zhentao, Y.; Xiaofei, C.; Jiannan, W.

    2016-12-01

    The fundamental mode is the primary component of surface wave derived from ambient noise. It is the basis of the method of structure imaging from ambient noise (e.g. SPAC, Aki 1957; F-K, Lascoss 1968; MUSIC, Schmidt 1986). It is well known, however, that if the higher modes of surface wave can be identified from data and are incorporated in the inversion of dispersion curves, the uncertainty in inversion results will be greatly reduced (e.g., Tokimastu,1997). Actually, the ambient noise indeed contains the higher modes as well in its raw data of ambient noise. If we could extract the higher modes from ambient noise, the structure inversion method of ambient noise would be greatly improved. In the past decade, there are many studies to improve SPAC and analyses the relationship of fundamental mode and higher mode (Ohri et al 2002; Asten et al. 2006; Tashiaki Ykoi 2010 ;Tatsunori Ikeda 2012). In this study, we will present a new method of identifying higher modes from ambient noise data by reprocessing the "surface waves' phases" derived from the ambient noise through cross-correlation analysis, and show preliminary application in structure inversion.

  5. VizieR Online Data Catalog: WINERED CN-red band emission in comet C/2013 R1 (Shinnaka+, 2017)

    NASA Astrophysics Data System (ADS)

    Shinnaka, Y.; Kawakita, H.; Kondo, S.; Ikeda, Y.; Kobayashi, N.; Hamano, S.; Sameshima, H.; Fukue, K.; Matsunaga, N.; Yasui, C.; Izumi, N.; Mizumoto, M.; Otsubo, S.; Takenaka, K.; Watase, A.; Kawanishi, T.; Nakanishi, K.; Nakaoka, T.

    2018-05-01

    High-resolution spectroscopic observations of comet C/2013 R1 (Lovejoy; hereafter, comet Lovejoy) in the near-infrared wavelength region were performed using the WINERED spectrograph (Ikeda et al. 2016SPIE.9908E..5ZI) mounted on the Nasmyth focus of the 1.3 m Araki telescope (F/10) at Koyama Astronomical Observatory, Japan (Yoshikawa et al. 2012SPIE.8444E..6GY). We used a slit of length 47" and width 1.5". This slit width corresponds to a spectral resolving power of R=28000 (two pixels). The observations of comet Lovejoy were performed on 2013 November 30, from 19:08 UT to 21:04 UT; the total integration time was 6000 s on source. The heliocentric and geocentric distances were 0.91 au and 0.49 au, respectively, and the relative velocities of the comet to the Sun and observer were -14.5 km/s and 25.8 km/s, respectively, at the observations. We put the comet at the center of the slit during the exposures. Other calibration data (darks, flats, and comparison-lamp frames) were also acquired. (1 data file).

  6. Hydrogen Sulfide Treatment Promotes Glucose Uptake by Increasing Insulin Receptor Sensitivity and Ameliorates Kidney Lesions in Type 2 Diabetes

    PubMed Central

    Xue, Rong; Hao, Dan-Dan; Sun, Ji-Ping; Li, Wen-Wen; Zhao, Man-Man; Li, Xing-Hui; Chen, Ying; Zhu, Jian-Hua; Ding, Ying-Jiong; Liu, Jun

    2013-01-01

    Abstract Aims: To examine if hydrogen sulfide (H2S) can promote glucose uptake and provide amelioration in type 2 diabetes. Results: Treatment with sodium hydrosulfide (NaHS, an H2S donor) increased glucose uptake in both myotubes and adipocytes. The H2S gas solution showed similar effects. The NaHS effects were blocked by an siRNA-mediated knockdown of the insulin receptor (IR). NaHS also increased phosphorylation of the IR, PI3K, and Akt. In Goto-Kakizaki (GK) diabetic rats, chronic NaHS treatment (30 μmol·kg−1·day−1) decreased fasting blood glucose, increased insulin sensitivity, and increased glucose tolerance with increased phosphorylation of PI3K and Akt in muscles. Similar insulin-sensitizing effects of NaHS treatment were also observed in Wistar rats. Moreover, glucose uptake was reduced in the cells with siRNA-mediated knockdown of the H2S-generating enzyme cystathionine γ-lyase in the presence or absence of exogenous H2S. Moreover, chronic NaHS treatment reduced oxygen species and the number of crescentic glomeruli in the kidney of GK rats. Innovation and Conclusion: This study provides the first piece of evidence for the insulin-sensitizing effect of NaHS/H2S in the both in vitro and in vivo models of insulin resistance. Rebound Track: This work was rejected during a standard peer review and rescued by the Rebound Peer Review (Antoxid Redox Signal 16: 293–296, 2012) with the following serving as open reviewers: Jin-Song Bian, Samuel Dudley, Hideo Kimura, and Xian Wang. Antioxid. Redox Signal. 19, 5–23. PMID:23293908

  7. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Saha, D., E-mail: sahaphys@gmail.com, E-mail: pmisra@rrcat.gov.in; Misra, P., E-mail: sahaphys@gmail.com, E-mail: pmisra@rrcat.gov.in; Joshi, M. P.

    In the present study, atomic layer deposition has been used to grow a series of Ti incorporated ZnO thin films by vertically stacking different numbers (n = 1–7) of ZnO/TiO{sub x} layers on (0001) sapphire substrates. The effects of defect states mediated chemisorption of O{sub 2} and/OH groups on the electrical properties of these films have been investigated by illuminating the samples under UV light inside a high vacuum optical cryostat. The ultra-thin film having one stacked layer (n = 1) did not show any change in its electrical resistance upon UV light exposure. On the contrary, marginal drop in the electrical resistivity wasmore » measured for the samples with n ≥ 3. Most surprisingly, the sample with n = 2 (thickness ∼ 12 nm) showed an insulator to metal transition upon UV light exposure. The temperature dependent electrical resistivity measurement on the as grown film (n = 2) showed insulating behaviour, i.e., diverging resistivity on extrapolation to T→ 0 K. However, upon UV light exposure, it transformed to a metallic state, i.e., finite resistivity at T → 0 K. Such an insulator-metal transition plausibly arises due to the de-trapping of conduction electrons from the surface defect sites which resulted in an upward shift of the Fermi level above the mobility edge. The low-temperature electron transport properties on the insulating film (n = 2) were investigated by a combined study of zero field electrical resistivity ρ(T) and magnetoresistance (MR) measurements. The observed negative MR was found to be in good agreement with the magnetic field induced suppression of quantum interference between forward-going paths of tunnelling electrons. Both ρ(T) and MR measurements provided strong evidence for the Efros-Shklovskii type variable range hopping conduction in the low-temperature (≤40 K) regime. Such studies on electron transport in ultra-thin n-type doped ZnO films are crucial to achieve optimum

  8. Developing the Digital Kyoto Collection in Education and Research.

    PubMed

    Hill, Mark Anthony

    2018-04-16

    The Kyoto embryo collection was begun in 1961 by Dr. Hideo Nishimura. The collection has been continuously developed and currently contains over 44,000 human normal and abnormal specimens. Beginning online in 1997, the internet provided an opportunity to make embryos from the collection widely available for research and educational purposes (http://tiny.cc/Embryo). These embryonic development resources have been continuously published and available from that time until today. Published in Japanese as an Atlas of Embryonic Development. Published online as the Kyoto Human Embryo Visualization Project (http://atlas.cac.med.kyoto-u.ac.jp) and also as the Human Embryo Atlas (http://tiny.cc/Human_Embryo_Atlas). Published now electronically as a digital eBook (http://tiny.cc/Kyoto_Collection_eBook). This new digital format allows incorporation of whole embryo and histology manipulable images, labels, and a linked glossary. New imaging modalities of magnetic resonance imaging (MRI) and episcopic fluorescence image capture (EFIC) can also be easily displayed as animations. For research, the collection specimens and histological sections have been extensively studied and published in several hundred papers, discussed here and elsewhere in this special edition. I will also describe how the Kyoto collection will now form a major partner of a new international embryology research group, the Digital Embryology Consortium (https://human-embryology.org). The digital Kyoto collection will be made available for remote researcher access, analysis, and comparison with other collections allowing new research and educational applications. This work was presented at the 40th Anniversary Commemoration Symposium of the Congenital Anomaly Research Center, Graduate School of Medicine, Kyoto University, Japan, November, 2015. Anat Rec, 2018. © 2018 Wiley Periodicals, Inc. © 2018 Wiley Periodicals, Inc.

  9. Anderson localized state as a predissipative state: irreversible emission of thermalized quanta from a dynamically delocalized state.

    PubMed

    Yamada, Hiroaki; Ikeda, Kensuke S

    2002-04-01

    It was shown that localization in one-dimensional disordered (quantum) electronic system is destroyed against coherent harmonic perturbations and the delocalized electron exhibits an unlimited diffusive motion [Yamada and Ikeda, Phys. Rev. E 59, 5214 (1999)]. The appearance of diffusion implies that the system has potential for irreversibility and dissipation. In the present paper, we investigate dissipative property of the dynamically delocalized state, and we show that an irreversible quasistationary energy flow indeed appears in the form of a "heat" flow when we couple the system with another dynamical degree of freedom. In the concrete we numerically investigate dissipative properties of a one-dimensional tight-binding electronic system perturbed by time-dependent harmonic forces, by coupling it with a quantum harmonic oscillator or a quantum anharmonic oscillator. It is demonstrated that if the on-site potential is spatially irregular an irreversible energy transfer from the scattered electron to the test oscillator occurs. Moreover, the test oscillator promptly approaches a thermalized state characterized by a well-defined time-dependent temperature. On the contrary, such a relaxation process cannot be observed at all for periodic potential systems. Our system is one of the minimal quantum systems in which a distinct nonequilibrium statistical behavior is self-induced.

  10. Suzaku  Observations of Heavily Obscured (Compton-thick) Active Galactic Nuclei Selected by the Swift/BAT Hard X-Ray Survey

    NASA Astrophysics Data System (ADS)

    Tanimoto, Atsushi; Ueda, Yoshihiro; Kawamuro, Taiki; Ricci, Claudio; Awaki, Hisamitsu; Terashima, Yuichi

    2018-02-01

    We present a uniform broadband X-ray (0.5–100.0 keV) spectral analysis of 12 Swift/Burst Alert Telescope selected Compton-thick ({log}{N}{{H}}/{{cm}}-2≥slant 24) active galactic nuclei (CTAGNs) observed with Suzaku. The Suzaku data of three objects are published here for the first time. We fit the Suzaku and Swift spectra with models utilizing an analytic reflection code and those utilizing the Monte-Carlo-based model from an AGN torus by Ikeda et al. The main results are as follows: (1) The estimated intrinsic luminosity of a CTAGN strongly depends on the model; applying Compton scattering to the transmitted component in an analytic model may largely overestimate the intrinsic luminosity at large column densities. (2) Unabsorbed reflection components are commonly observed, suggesting that the tori are clumpy. (3) Most of CTAGNs show small scattering fractions (<0.5%), implying a buried AGN nature. (4) Comparison with the results obtained for Compton-thin AGNs suggests that the properties of these CTAGNs can be understood as a smooth extension from Compton-thin AGNs with heavier obscuration; we find no evidence that the bulk of the population of hard-X-ray-selected CTAGNs are different from less obscured objects.

  11. Bayesian data assimilation provides rapid decision support for vector-borne diseases.

    PubMed

    Jewell, Chris P; Brown, Richard G

    2015-07-06

    Predicting the spread of vector-borne diseases in response to incursions requires knowledge of both host and vector demographics in advance of an outbreak. Although host population data are typically available, for novel disease introductions there is a high chance of the pathogen using a vector for which data are unavailable. This presents a barrier to estimating the parameters of dynamical models representing host-vector-pathogen interaction, and hence limits their ability to provide quantitative risk forecasts. The Theileria orientalis (Ikeda) outbreak in New Zealand cattle demonstrates this problem: even though the vector has received extensive laboratory study, a high degree of uncertainty persists over its national demographic distribution. Addressing this, we develop a Bayesian data assimilation approach whereby indirect observations of vector activity inform a seasonal spatio-temporal risk surface within a stochastic epidemic model. We provide quantitative predictions for the future spread of the epidemic, quantifying uncertainty in the model parameters, case infection times and the disease status of undetected infections. Importantly, we demonstrate how our model learns sequentially as the epidemic unfolds and provide evidence for changing epidemic dynamics through time. Our approach therefore provides a significant advance in rapid decision support for novel vector-borne disease outbreaks. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

  12. Isolation and genetic characterization of Aurantimonas and Methylobacterium strains from stems of hypernodulated soybeans.

    PubMed

    Anda, Mizue; Ikeda, Seishi; Eda, Shima; Okubo, Takashi; Sato, Shusei; Tabata, Satoshi; Mitsui, Hisayuki; Minamisawa, Kiwamu

    2011-01-01

    The aims of this study were to isolate Aurantimonas and Methylobacterium strains that responded to soybean nodulation phenotypes and nitrogen fertilization rates in a previous culture-independent analysis (Ikeda et al. ISME J. 4:315-326, 2010). Two strategies were adopted for isolation from enriched bacterial cells prepared from stems of field-grown, hypernodulated soybeans: PCR-assisted isolation for Aurantimonas and selective cultivation for Methylobacterium. Thirteen of 768 isolates cultivated on Nutrient Agar medium were identified as Aurantimonas by colony PCR specific for Aurantimonas and 16S rRNA gene sequencing. Meanwhile, among 187 isolates on methanol-containing agar media, 126 were identified by 16S rRNA gene sequences as Methylobacterium. A clustering analysis (>99% identity) of the 16S rRNA gene sequences for the combined datasets of the present and previous studies revealed 4 and 8 operational taxonomic units (OTUs) for Aurantimonas and Methylobacterium, respectively, and showed the successful isolation of target bacteria for these two groups. ERIC- and BOX-PCR showed the genomic uniformity of the target isolates. In addition, phylogenetic analyses of Aurantimonas revealed a phyllosphere-specific cluster in the genus. The isolates obtained in the present study will be useful for revealing unknown legume-microbe interactions in relation to the autoregulation of nodulation.

  13. Characterization of Peptides from Capsicum annuum Hybrid Seeds with Inhibitory Activity Against α-Amylase, Serine Proteinases and Fungi.

    PubMed

    Vieira Bard, Gabriela C; Nascimento, Viviane V; Ribeiro, Suzanna F F; Rodrigues, Rosana; Perales, Jonas; Teixeira-Ferreira, André; Carvalho, André O; Fernandes, Katia Valevski S; Gomes, Valdirene M

    2015-04-01

    Over the last several years, the activity of antimicrobial peptides (AMPs), isolated from plant species, against different microorganisms has been demonstrated. More recently, some of these AMPs have been described as potent inhibitors of α-amylases and serine proteinases from insects and mammals. The aim of this work was to obtain AMPs from protein extracts of a hybrid Capsicum (Ikeda × UENF 1381) seeds and to evaluate their microbial and enzyme inhibitory activities. Initially, proteins were extracted from the Capsicum hybrid seeds in buffer (sodium phosphate pH 5.4,) and precipitated with ammonium sulfate (90% saturated). Extract of hybrid seeds was subjected to size exclusion chromatography, and three fractions were obtained: S1, S2 and S3. The amino acid sequence, obtained by mass spectrometry, of the 6 kDa peptide from the S3 fraction, named HyPep, showed 100% identity with PSI-1.2, a serine protease inhibitor isolated from C. annuum seeds, however the bifunctionality of this inhibitor against two enzymes is being shown for the first time in this work. The S3 fraction showed the highest antifungal activity, inhibiting all the yeast strains tested, and it also exhibited inhibitory activity against human salivary and Callosobruchus maculatus α-amylases as well as serine proteinases.

  14. Bayesian data assimilation provides rapid decision support for vector-borne diseases

    PubMed Central

    Jewell, Chris P.; Brown, Richard G.

    2015-01-01

    Predicting the spread of vector-borne diseases in response to incursions requires knowledge of both host and vector demographics in advance of an outbreak. Although host population data are typically available, for novel disease introductions there is a high chance of the pathogen using a vector for which data are unavailable. This presents a barrier to estimating the parameters of dynamical models representing host–vector–pathogen interaction, and hence limits their ability to provide quantitative risk forecasts. The Theileria orientalis (Ikeda) outbreak in New Zealand cattle demonstrates this problem: even though the vector has received extensive laboratory study, a high degree of uncertainty persists over its national demographic distribution. Addressing this, we develop a Bayesian data assimilation approach whereby indirect observations of vector activity inform a seasonal spatio-temporal risk surface within a stochastic epidemic model. We provide quantitative predictions for the future spread of the epidemic, quantifying uncertainty in the model parameters, case infection times and the disease status of undetected infections. Importantly, we demonstrate how our model learns sequentially as the epidemic unfolds and provide evidence for changing epidemic dynamics through time. Our approach therefore provides a significant advance in rapid decision support for novel vector-borne disease outbreaks. PMID:26136225

  15. Prototapirella ciliates from wild habituated Virunga mountain gorillas (Gorilla beringei beringei) in Rwanda with the descriptions of two new species.

    PubMed

    Ito, Akira; Eckardt, Winnie; Stoinski, Tara S; Gillespie, Thomas R; Tokiwa, Toshihiro

    2016-06-01

    The morphology of Prototapirella fosseyi n. sp., P. rwanda n. sp. and P. gorillaeImai, Ikeda, Collet, and Bonhomme, 1991 in the Entodiniomorphida were described from the mountain gorillas, Gorilla beringei beringei, in Rwanda. The ciliates have a retractable adoral ciliary zone, four non-retractable ciliary tufts in four caudalia, and one broad skeletal plate beneath the body surface. P. rwanda has a dorsal lobe and ventral lobes in two rows whereas P. fosseyi has no lobes. These two new species have an elongated body, a flat tail flap leaning to the ventral, a macronucleus with a tapering anterior end, a round posterior end and a shallow depression on the dorsal side, a micronucleus lying near the anterior end of macronucleus, a thin left region of the skeletal plate, a distinct skeletal rod plate, and four contractile vacuoles. P. gorillae has some variations in the nuclei and the skeletal plate. The infraciliary bands of three Prototapirella species were the same as some Triplumaria species; a C-shaped adoral polybrachykinety, a slender perivestibular polybrachykinety, and paralabial kineties in their retractable adoral ciliary zone and short lateral polybrachykineties in their four caudalia. The perivestibular polybrachykinety is joined only to the right end of adoral polybrachykinety. Copyright © 2016 Elsevier GmbH. All rights reserved.

  16. Reduction of opioid side effects by prophylactic measures of palliative care team may result in improved quality of life.

    PubMed

    Myotoku, Michiaki; Nakanishi, Akiko; Kanematsu, Miwa; Sakaguchi, Noriko; Hashimoto, Norio; Koyama, Fumiko; Yamaguchi, Seiji; Ikeda, Kenji; Konishi, Hiroki; Hirotani, Yoshihiko

    2010-04-01

    In February 2002, the palliative care team was established in Ikeda Municipal Hospital to improve palliative care. We investigated changes in the incidences of side effects related to opioids, and evaluated palliative care team activities. Regarding inpatients for whom narcotics were prescribed in our hospital in the years of 2002 (from October 1, 2002 until September 30, 2003), 2004 (from October 1, 2004 until September 30, 2005), and 2006 (from October 1, 2006 until September 30, 2007), we surveyed the rates at which laxatives or antiemetics were prescribed, frequency of defecation/its state before and after the start of narcotic therapy, frequency of nausea/vomiting, and dietary intake. The proportions of patients in whom laxatives were simultaneously prescribed during opioid therapy in 2002, 2004, and 2006 were 43.5%, 78.7%, and 75.6%, respectively. The proportions of those in whom antiemetics were combined with opioids were 45.7%, 78.7%, and 78.0%, respectively. The incidences of constipation were 50.0%, 39.3%, and 37.8%, respectively. Those of nausea/vomiting were 30.4%, 21.3%, and 9.8%, respectively. Those of anorexia were 65.3%, 39.4%, and 15.4%, respectively. These results suggest that palliative care team activities facilitated appropriate drug prescription during opioid therapy, reducing the appearance of side effects, with likelihood of improved quality of life.

  17. Testing the Feasibility and Usability of a Novel Smartphone-Based Self-Management Support System for Dialysis Patients: A Pilot Study.

    PubMed

    Hayashi, Aki; Yamaguchi, Satoko; Waki, Kayo; Fujiu, Katsuhito; Hanafusa, Norio; Nishi, Takahiro; Tomita, Hyoe; Kobayashi, Haruka; Fujita, Hideo; Kadowaki, Takashi; Nangaku, Masaomi; Ohe, Kazuhiko

    2017-04-20

    Diet and fluid restrictions that need continuous self-management are among the most difficult aspects of dialysis treatment. Smartphone applications may be useful for supporting self-management. Our objective is to investigate the feasibility and usability of a novel smartphone-based self-management support system for dialysis patients. We developed the Self-Management and Recording System for Dialysis (SMART-D), which supports self-monitoring of three mortality-related factors that can be modified by lifestyle: interdialytic weight gain and predialysis serum potassium and phosphorus concentrations. Data is displayed graphically, with all data evaluated automatically to determine whether they achieve the values suggested by the Japanese Society for Dialysis Therapy guidelines. In a pilot study, 9 dialysis patients used SMART-D system for 2 weeks. A total of 7 of them completed questionnaires rating their assessment of SMART-D's usability and their satisfaction with the system. In addition, the Kidney Disease Quality of Life scale was compared before and after the study period. All 9 participants were able to use SMART-D with no major problems. Completion rates for body weight, pre- and postdialysis weight, and serum potassium and phosphorus concentrations were, respectively, 89% (SD 23), 95% (SD 7), and 78% (SD 44). Of the 7 participants who completed the usability survey, all were motivated by the sense of security derived from using the system, and 6 of the 7 (86%) reported that using SMART-D helped improve their lifestyle and self-management. Using SMART-D was feasible, and the system was well regarded by patients. Further study with larger scale cohorts and longer study and follow-up periods is needed to evaluate the effects of SMART-D on clinical outcomes and quality of life. ©Aki Hayashi, Satoko Yamaguchi, Kayo Waki, Katsuhito Fujiu, Norio Hanafusa, Takahiro Nishi, Hyoe Tomita, Haruka Kobayashi, Hideo Fujita, Takashi Kadowaki, Masaomi Nangaku, Kazuhiko Ohe

  18. Free fatty acid receptor 3 is a key target of short chain fatty acid. What is the impact on the sympathetic nervous system?

    PubMed

    López Soto, Eduardo Javier; Gambino, Luisina Ongaro; Mustafá, Emilio Román

    2014-01-01

    Nervous system (NS) activity participates in metabolic homeostasis by detecting peripheral signal molecules derived from food intake and energy balance. High quality diets are thought to include fiber-rich foods like whole grain rice, breads, cereals, and grains. Several studies have associated high consumption of fiber-enriched diets with a reduced risk of diabetes, obesity, and gastrointestinal disorders. In the lower intestine, anaerobic fermentation of soluble fibers by microbiota produces short chain fatty acids (SCFAs), key energy molecules that have a recent identified leading role in the intestinal gluconeogenesis, promoting beneficial effects on glucose tolerance and insulin resistance. SCFAs are also signaling molecules that bind to specific G-protein coupled receptors (GPCRs) named Free Fatty Acid Receptor 3 (FFA3, GPR41) and 2 (FFA2, GPR43). However, how SCFAs impact NS activity through their GPCRs is poorly understood. Recently, studies have demonstrated the presence of FFA2 and FFA3 in the sympathetic NS of rat, mouse and human. Two studies have showed that FFA3 activation by SCFAs increases firing and norepinephrine (NE) release from sympathetic neurons. However, the recent study from the Ikeda Laboratory revealed that activation of FFA3 by SCFAs impairs N-type calcium channel (NTCC) activity, which contradicts the idea of FFA3 activation leading to increased action potential evoked NE release. Here we will discuss the scope of the latter study and the putative physiological role of SCFAs and FFAs in the sympathetic NS.

  19. EDITORIAL: Focus on Quantum Control

    NASA Astrophysics Data System (ADS)

    Rabitz, Herschel

    2009-10-01

    represent two-photon power spectra of arbitrarily and adaptively shaped broadband laser pulses M A Montgomery and N H Damrauer Accurate and efficient implementation of the von Neumann representation for laser pulses with discrete and finite spectra Frank Dimler, Susanne Fechner, Alexander Rodenberg, Tobias Brixner and David J Tannor Coherent strong-field control of multiple states by a single chirped femtosecond laser pulse M Krug, T Bayer, M Wollenhaupt, C Sarpe-Tudoran, T Baumert, S S Ivanov and N V Vitanov Quantum-state measurement of ionic Rydberg wavepackets X Zhang and R R Jones On the paradigm of coherent control: the phase-dependent light-matter interaction in the shaping window Tiago Buckup, Jurgen Hauer and Marcus Motzkus Use of the spatial phase of a focused laser beam to yield mechanistic information about photo-induced chemical reactions V J Barge, Z Hu and R J Gordon Coherent control of multiple vibrational excitations for optimal detection S D McGrane, R J Scharff, M Greenfield and D S Moore Mode selectivity with polarization shaping in the mid-IR David B Strasfeld, Chris T Middleton and Martin T Zanni Laser-guided relativistic quantum dynamics Chengpu Liu, Markus C Kohler, Karen Z Hatsagortsyan, Carsten Muller and Christoph H Keitel Continuous quantum error correction as classical hybrid control Hideo Mabuchi Quantum filter reduction for measurement-feedback control via unsupervised manifold learning Anne E B Nielsen, Asa S Hopkins and Hideo Mabuchi Control of the temporal profile of the local electromagnetic field near metallic nanostructures Ilya Grigorenko and Anatoly Efimov Laser-assisted molecular orientation in gaseous media: new possibilities and applications Dmitry V Zhdanov and Victor N Zadkov Optimization of laser field-free orientation of a state-selected NO molecular sample Arnaud Rouzee, Arjan Gijsbertsen, Omair Ghafur, Ofer M Shir, Thomas Back, Steven Stolte and Marc J J Vrakking Controlling the sense of molecular rotation Sharly Fleischer

  20. Effects of Acutely Intermittent Hypoxic Exposure on Running Economy and Physical Performance in Basketball Players.

    PubMed

    Kilding, Andrew E; Dobson, Bryan P; Ikeda, Erika

    2016-07-01

    Kilding, AE, Dobson, BP, and Ikeda, E. Effects of acutely intermittent hypoxic exposure on running economy and physical performance in basketball players. J Strength Cond Res 30(7): 2033-2042, 2016-The aim of this study was to determine the effect of short duration intermittent hypoxic exposure (IHE) on physical performance in basketball players. Using a single-blind placebo-controlled group design, 14 trained basketball players were subjected to 15 days of passive short duration IHE (n = 7), or normoxic control (CON, n = 7), using a biofeedback nitrogen dilution device. A range of physiological, performance, and hematological variables were measured at baseline, and 10 days after IHE. After intervention, the IHE group, relative to the CON group, exhibited improvements in the Yo-Yo intermittent recovery level 1 (+4.8 ± 1.6%; effect size [ES]: 1.0 ± 0.4) and repeated high-intensity exercise test performance (-3.5 ± 1.6%; ES: -0.4 ± 0.2). Changes in hematological parameters were minimal, although soluble transferrin receptor increased after IHE (+9.2 ± 10.1%; ES: 0.3 ± 0.3). Running economy at 11 km·h (-9.0 ± 9.7%; ES: -0.7 ± 0.7) and 13 km·h was improved (-8.2 ± 6.9%; ES: -0.7 ± 0.5), but changes to V[Combining Dot Above]O2peak, HRpeak, and lactate were unclear. In summary, acutely IHE resulted in worthwhile changes in physical performance tests among competitive basketball players. However, physiological measures explaining the performance enhancement were in most part unclear.

  1. Isolation of a novel Orientia species (O. chuto sp. nov.) from a patient infected in Dubai.

    PubMed

    Izzard, Leonard; Fuller, Andrew; Blacksell, Stuart D; Paris, Daniel H; Richards, Allen L; Aukkanit, Nuntipa; Nguyen, Chelsea; Jiang, Ju; Fenwick, Stan; Day, Nicholas P J; Graves, Stephen; Stenos, John

    2010-12-01

    In July 2006, an Australian tourist returning from Dubai, in the United Arab Emirates (UAE), developed acute scrub typhus. Her signs and symptoms included fever, myalgia, headache, rash, and eschar. Orientia tsutsugamushi serology demonstrated a 4-fold rise in antibody titers in paired serum collections (1:512 to 1:8,192), with the sera reacting strongest against the Gilliam strain antigen. An Orientia species was isolated by the in vitro culture of the patient's acute blood taken prior to antibiotic treatment. The gene sequencing of the 16S rRNA gene (rrs), partial 56-kDa gene, and the full open reading frame 47-kDa gene was performed, and comparisons of this new Orientia sp. isolate to previously characterized strains demonstrated significant sequence diversity. The closest homology to the rrs sequence of the new Orientia sp. isolate was with three strains of O. tsutsugamushi (Ikeda, Kato, and Karp), with a nucleotide sequence similarity of 98.5%. The closest homology to the 47-kDa gene sequence was with O. tsutsugamushi strain Gilliam, with a nucleotide similarity of 82.3%, while the closest homology to the 56-kDa gene sequence was with O. tsutsugamushi strain TA686, with a nucleotide similarity of 53.1%. The molecular divergence and geographically unique origin lead us to believe that this organism should be considered a novel species. Therefore, we have proposed the name "Orientia chuto," and the prototype strain of this species is strain Dubai, named after the location in which the patient was infected.

  2. Isolation of a Novel Orientia Species (O. chuto sp. nov.) from a Patient Infected in Dubai ▿

    PubMed Central

    Izzard, Leonard; Fuller, Andrew; Blacksell, Stuart D.; Paris, Daniel H.; Richards, Allen L.; Aukkanit, Nuntipa; Nguyen, Chelsea; Jiang, Ju; Fenwick, Stan; Day, Nicholas P. J.; Graves, Stephen; Stenos, John

    2010-01-01

    In July 2006, an Australian tourist returning from Dubai, in the United Arab Emirates (UAE), developed acute scrub typhus. Her signs and symptoms included fever, myalgia, headache, rash, and eschar. Orientia tsutsugamushi serology demonstrated a 4-fold rise in antibody titers in paired serum collections (1:512 to 1:8,192), with the sera reacting strongest against the Gilliam strain antigen. An Orientia species was isolated by the in vitro culture of the patient's acute blood taken prior to antibiotic treatment. The gene sequencing of the 16S rRNA gene (rrs), partial 56-kDa gene, and the full open reading frame 47-kDa gene was performed, and comparisons of this new Orientia sp. isolate to previously characterized strains demonstrated significant sequence diversity. The closest homology to the rrs sequence of the new Orientia sp. isolate was with three strains of O. tsutsugamushi (Ikeda, Kato, and Karp), with a nucleotide sequence similarity of 98.5%. The closest homology to the 47-kDa gene sequence was with O. tsutsugamushi strain Gilliam, with a nucleotide similarity of 82.3%, while the closest homology to the 56-kDa gene sequence was with O. tsutsugamushi strain TA686, with a nucleotide similarity of 53.1%. The molecular divergence and geographically unique origin lead us to believe that this organism should be considered a novel species. Therefore, we have proposed the name “Orientia chuto,” and the prototype strain of this species is strain Dubai, named after the location in which the patient was infected. PMID:20926708

  3. Rise of pairwise thermal entanglement for an alternating Ising and Heisenberg spin chain in an arbitrarily oriented magnetic field

    NASA Astrophysics Data System (ADS)

    Rojas, M.; de Souza, S. M.; Rojas, Onofre

    2014-03-01

    Typically two particles (spins) could be maximally entangled at zero temperature, and for a certain temperature the phenomenon of entanglement vanishes at the threshold temperature. For the Heisenberg coupled model or even the Ising model with a transverse magnetic field, one can observe some rise of entanglement even for a disentangled region at zero temperature. So we can understand this emergence of entanglement at finite temperature as being due to the mixing of some maximally entangled states with some other untangled states. Here, we present a simple one-dimensional Ising model with alternating Ising and Heisenberg spins in an arbitrarily oriented magnetic field, which can be mapped onto the classical Ising model with a magnetic field. This model does not show any evidence of entanglement at zero temperature, but surprisingly at finite temperature rise a pairwise thermal entanglement between two untangled spins at zero temperature when an arbitrarily oriented magnetic field is applied. This effect is a purely magnetic field, and the temperature dependence, as soon as the temperature increases, causes a small increase in concurrence, achieving its maximum at around 0.1. Even for long-range entanglement, a weak concurrence still survives. There are also some real materials that could serve as candidates that would exhibit this effect, such as Dy(NO3)(DMSO)2Cu(opba)(DMSO)2 [DMSO = dimethyl sulfoxide; opba = o-phenylenebis(oxamoto)] [J. Strečka, M. Hagiwara, Y. Han, T. Kida, Z. Honda, and M. Ikeda, Condens. Matter Phys. 15, 43002 (2012), 10.5488/CMP.15.43002].

  4. Coexistence of Multiple Nonlinear States in a Tristable Passive Kerr Resonator

    NASA Astrophysics Data System (ADS)

    Anderson, Miles; Wang, Yadong; Leo, François; Coen, Stéphane; Erkintalo, Miro; Murdoch, Stuart G.

    2017-07-01

    Passive Kerr cavities driven by coherent laser fields display a rich landscape of nonlinear physics, including bistability, pattern formation, and localized dissipative structures (solitons). Their conceptual simplicity has for several decades offered an unprecedented window into nonlinear cavity dynamics, providing insights into numerous systems and applications ranging from all-optical memory devices to microresonator frequency combs. Yet despite the decades of study, a recent theoretical work has surprisingly alluded to an entirely new and unexplored paradigm in the regime where nonlinearly tilted cavity resonances overlap with one another [T. Hansson and S. Wabnitz, J. Opt. Soc. Am. B 32, 1259 (2015), 10.1364/JOSAB.32.001259]. We use synchronously driven fiber ring resonators to experimentally access this regime and observe the rise of new nonlinear dissipative states. Specifically, we observe, for the first time to the best of our knowledge, the stable coexistence of temporal Kerr cavity solitons and extended modulation instability (Turing) patterns, and perform real-time measurements that unveil the dynamics of the ensuing nonlinear structure. When operating in the regime of continuous wave tristability, we further observe the coexistence of two distinct cavity soliton states, one of which can be identified as a "super" cavity soliton, as predicted by Hansson and Wabnitz. Our experimental findings are in excellent agreement with theoretical analyses and numerical simulations of the infinite-dimensional Ikeda map that governs the cavity dynamics. The results from our work reveal that experimental systems can support complex combinations of distinct nonlinear states, and they could have practical implications to future microresonator-based frequency comb sources.

  5. Long-read whole genome sequencing and comparative analysis of six strains of the human pathogen Orientia tsutsugamushi.

    PubMed

    Batty, Elizabeth M; Chaemchuen, Suwittra; Blacksell, Stuart; Richards, Allen L; Paris, Daniel; Bowden, Rory; Chan, Caroline; Lachumanan, Ramkumar; Day, Nicholas; Donnelly, Peter; Chen, Swaine; Salje, Jeanne

    2018-06-01

    Orientia tsutsugamushi is a clinically important but neglected obligate intracellular bacterial pathogen of the Rickettsiaceae family that causes the potentially life-threatening human disease scrub typhus. In contrast to the genome reduction seen in many obligate intracellular bacteria, early genetic studies of Orientia have revealed one of the most repetitive bacterial genomes sequenced to date. The dramatic expansion of mobile elements has hampered efforts to generate complete genome sequences using short read sequencing methodologies, and consequently there have been few studies of the comparative genomics of this neglected species. We report new high-quality genomes of O. tsutsugamushi, generated using PacBio single molecule long read sequencing, for six strains: Karp, Kato, Gilliam, TA686, UT76 and UT176. In comparative genomics analyses of these strains together with existing reference genomes from Ikeda and Boryong strains, we identify a relatively small core genome of 657 genes, grouped into core gene islands and separated by repeat regions, and use the core genes to infer the first whole-genome phylogeny of Orientia. Complete assemblies of multiple Orientia genomes verify initial suggestions that these are remarkable organisms. They have larger genomes compared with most other Rickettsiaceae, with widespread amplification of repeat elements and massive chromosomal rearrangements between strains. At the gene level, Orientia has a relatively small set of universally conserved genes, similar to other obligate intracellular bacteria, and the relative expansion in genome size can be accounted for by gene duplication and repeat amplification. Our study demonstrates the utility of long read sequencing to investigate complex bacterial genomes and characterise genomic variation.

  6. Characterization of the diatomite binding domain in the ribosomal protein L2 from E. coli and functions as an affinity tag.

    PubMed

    Li, Junhua; Zhang, Yang; Yang, Yanjun

    2013-03-01

    The ribosomal protein L2, a constituent protein of the 50S large ribosomal subunit, can be used as Si-tag using silica particles for the immobilization and purification of recombinant proteins (Ikeda et al. (Protein Expr Purif 71:91-95, 2010); Taniguchi et al. (Biotechnol Bioeng 96:1023-1029, 2007)). We applied a diatomite powder, a sedimentary rock mainly composed with diatoms silica, as an affinity solid phase and small ubiquitin-like modifier (SUMO) technology to release a target protein from the solid phase. The L2 (203-273) was the sufficient region for the adsorption of ribosomal protein L2 on diatomite. We comparatively analyzed the different adsorption properties of the two deleted proteins of L2 (L2 (1-60, 203-273) and L2 (203-273)) on diatomite. The time required to reach adsorption equilibrium of L2 (203-273) fusion protein on diatomite was shorter than that of L2 (1-60, 203-273) fusion protein. The maximum adsorption capacity of L2 (203-273) fusion protein was larger than that of L2 (1-60, 203-273) fusion protein. In order to study whether the L2 (203-273) can function as an affinity purification tag, SUMO was introduced as one specific protease cleavage site between the target protein and the purification tags. The L2 (203-273) and SUMO fusion protein purification method was tested using enhanced green fluorescent protein as a model protein; the result shows that the purification performance of this affinity purification method was good. The strong adsorption characteristic of L2 (203-273) on diatomite also provides a potential protein fusion tag for the immobilization of enzyme.

  7. Study of Swift/Bat Selected Low-luminosity Active Galactic Nuclei Observed with Suzaku

    NASA Astrophysics Data System (ADS)

    Kawamuro, Taiki; Ueda, Yoshihiro; Tazaki, Fumie; Terashima, Yuichi; Mushotzky, Richard

    2016-11-01

    We systematically analyze the broadband (0.5-200 keV) X-ray spectra of hard X-ray (>10 keV) selected local low-luminosity active galactic nuclei (LLAGNs) observed with Suzaku and Swift/BAT. The sample consists of 10 LLAGNs detected with Swift/BAT with intrinsic 14-195 keV luminosities smaller than 1042 erg s-1 available in the Suzaku archive, covering a wide range of the Eddington ratio from 10-5 to 10-2. The overall spectra can be reproduced with an absorbed cut-off power law, often accompanied by reflection components from distant cold matter, and/or optically thin thermal emission from the host galaxy. In all of the objects, relativistic reflection components from the innermost disk are not required. Eight objects show a significant narrow iron-Kα emission line. Comparing their observed equivalent widths with the predictions from the Monte-Carlo-based torus model by Ikeda et al. (2009), we constrain the column density in the equatorial plane to be {log} {N}{{H}}{{eq}}\\gt 22.7, or the torus half-opening angle θ oa < 70°. We infer that the Eddington ratio (λ Edd) is a key parameter that determines the torus structure of LLAGNs: the torus becomes large at λ Edd ≳ 2 × 10-4, whereas at lower accretion rates it is little developed. The luminosity correlation between the hard X-ray and mid-infrared (MIR) bands of the LLAGNs follows the same correlation as for more luminous AGNs. This implies that mechanisms other than AGN-heated dust are responsible for the MIR emission in low Eddington ratio LLAGNs.

  8. Laboratory Studies on the Formation of Three C2H4O Isomers-Acetaldehyde (CH3CHO), Ethylene Oxide (c-C2H4O), and Vinyl Alcohol (CH2CHOH)-in Interstellar and Cometary Ices

    NASA Astrophysics Data System (ADS)

    Bennett, Chris J.; Osamura, Yoshihiro; Lebar, Matt D.; Kaiser, Ralf I.

    2005-11-01

    Laboratory experiments were conducted to unravel synthetic routes to form three C2H4O isomers-acetaldehyde (CH3CHO), ethylene oxide (c-C2H4O), and vinyl alcohol (CH2CHOH)-in extraterrestrial ices via electronic energy transfer processes initiated by electrons in the track of MeV ion trajectories. Here we present the results of electron irradiation on a 2:1 mixture of carbon dioxide (CO2) and ethylene (C2H4). Our studies suggest that suprathermal oxygen atoms can add to the carbon-carbon π bond of an ethylene molecule to form initially an oxirene diradical (addition to one carbon atom) and the cyclic ethylene oxide molecule (addition to two carbon atoms) at 10 K. The oxirene diradical can undergo a [1, 2]-H shift to the acetaldehyde molecule. Both the ethylene oxide and the acetaldehyde isomers can be stabilized in the surrounding ice matrix. To a minor amount, suprathermal oxygen atoms can insert into a carbon-hydrogen bond of the ethylene molecule, forming vinyl alcohol. Once these isomers have been synthesized inside the ice layers of the coated grains in cold molecular clouds, the newly formed molecules can sublime as the cloud reaches the hot molecular core stage. These laboratory investigations help to explain astronomical observations by Nummelin et al. and Ikeda et al. toward massive star-forming regions and hot cores, where observed fractional abundances of these isomers are higher than can be accounted for by gas-phase reactions alone. Similar synthetic routes could help explain the formation of acetaldehyde and ethylene oxide in comet C/1995 O1 (Hale-Bopp) and also suggest a presence of both isomers in Titan's atmosphere.

  9. Raman spectroscopy on ice cores from Greenland and Antarctica

    NASA Astrophysics Data System (ADS)

    Weikusat, C.; Kipfstuhl, S.

    2012-04-01

    Ice cores are invaluable archives for the reconstruction of the climatic history of the earth. Besides the analysis of various climatic processes from isotopes and chemical signatures they offer the unique possibility of directly extracting the past atmosphere from gaseous inclusions in the ice. Many aspects of the formation and alterations of these inclusions, e.g. the entrapment of air at the firn-ice-transition, the formation of crystalline gas hydrates (clathrates) from the bubbles or the structural relaxation during storage of the cores, need to be better understood to enable reliable interpretations of the obtained data. Modern micro Raman spectroscopy is an excellent tool to obtain high-quality data for all of these aspects. It has been productively used for phase identification of solid inclusions [1], investigation of air clathrates [2] and high-resolution measurements of N2/O2 mixing ratios inside individual air bubbles [3,4]. Detailed examples of the various uses of Raman spectroscopy will be presented along with practical information about the techniques required to obtain high-quality spectra. Retrieval and interpretation of quantitative data from the spectra will be explained. Future possibilities for advanced uses of Raman spectroscopy for ice core research will be discussed. [1] T. Sakurai et al., 2009, Direct observation of salts as micro-inclusions in the Greenland GRIP ice core. Journal of Glaciology, 55, 777-783. [2] F. Pauer et al., 1995, Raman spectroscopic study of nitrogen/oxygen ratio in natural ice clathrates in the GRIP ice core. Geophysical Research Letters, 22, 969-971. [3] T. Ikeda-Fukazawa et al., 2001, Variation in N2/O2 ratio of occluded air in Dome Fuji antarctic ice. Journal of Geophysical Research, 106, 17799-17810. [4] C. Weikusat et al., Raman spectroscopy of gaseous inclusions in EDML ice core: First results - microbubbles. Journal of Glaciology, accepted.

  10. Nuclear structure properties and stellar weak rates for 76Se: Unblocking of the Gamow Teller strength

    NASA Astrophysics Data System (ADS)

    Nabi, Jameel-Un; Ishfaq, Mavra; Böyükata, Mahmut; Riaz, Muhammad

    2017-10-01

    At finite temperatures (≥ 107K), 76Se is abundant in the core of massive stars and electron capture on 76Se has a consequential role to play in the dynamics of core-collapse. The present work may be classified into two main categories. In the first phase we study the nuclear structure properties of 76Se using the interacting boson model-1 (IBM-1). The IBM-1 investigations include the energy levels, B (E 2) values and the prediction of the geometry. We performed the extended consistent-Q formalism (ECQF) calculation and later the triaxial formalism calculation (constructed by adding the cubic term to the ECQF). The geometry of 76Se can be envisioned within the formalism of the potential energy surface based on the classical limit of IBM-1 model. In the second phase, we reconfirm the unblocking of the Gamow-Teller (GT) strength in 76Se (a test case for nuclei having N > 40 and Z < 40). Using the deformed pn-QRPA model we calculate GT transitions, stellar electron capture cross section (within the limit of low momentum transfer) and stellar weak rates for 76Se. The distinguishing feature of our calculation is a state-by-state evaluation of stellar weak rates in a fully microscopic fashion. Results are compared with experimental data and previous calculations. The calculated GT distribution fulfills the Ikeda sum rule. Rates for β-delayed neutrons and emission probabilities are also calculated. Our study suggests that at high stellar temperatures and low densities, the β+-decay on 76Se should not be neglected and needs to be taken into consideration along with electron capture rates for simulation of presupernova evolution of massive stars.

  11. Predicting the potential environmental suitability for Theileria orientalis transmission in New Zealand cattle using maximum entropy niche modelling.

    PubMed

    Lawrence, K E; Summers, S R; Heath, A C G; McFadden, A M J; Pulford, D J; Pomroy, W E

    2016-07-15

    The tick-borne haemoparasite Theileria orientalis is the most important infectious cause of anaemia in New Zealand cattle. Since 2012 a previously unrecorded type, T. orientalis type 2 (Ikeda), has been associated with disease outbreaks of anaemia, lethargy, jaundice and deaths on over 1000 New Zealand cattle farms, with most of the affected farms found in the upper North Island. The aim of this study was to model the relative environmental suitability for T. orientalis transmission throughout New Zealand, to predict the proportion of cattle farms potentially suitable for active T. orientalis infection by region, island and the whole of New Zealand and to estimate the average relative environmental suitability per farm by region, island and the whole of New Zealand. The relative environmental suitability for T. orientalis transmission was estimated using the Maxent (maximum entropy) modelling program. The Maxent model predicted that 99% of North Island cattle farms (n=36,257), 64% South Island cattle farms (n=15,542) and 89% of New Zealand cattle farms overall (n=51,799) could potentially be suitable for T. orientalis transmission. The average relative environmental suitability of T. orientalis transmission at the farm level was 0.34 in the North Island, 0.02 in the South Island and 0.24 overall. The study showed that the potential spatial distribution of T. orientalis environmental suitability was much greater than presumed in the early part of the Theileria associated bovine anaemia (TABA) epidemic. Maximum entropy offers a computer efficient method of modelling the probability of habitat suitability for an arthropod vectored disease. This model could help estimate the boundaries of the endemically stable and endemically unstable areas for T. orientalis transmission within New Zealand and be of considerable value in informing practitioner and farmer biosecurity decisions in these respective areas. Copyright © 2016 Elsevier B.V. All rights reserved.

  12. Solar System Chaos and its climatic and biogeochemical consequences

    NASA Astrophysics Data System (ADS)

    Ikeda, M.; Tada, R.; Ozaki, K.; Olsen, P. E.

    2017-12-01

    Insolation changes caused by changes in Earth's orbital parameters are the main driver of climatic variations, whose pace has been used for astronomically-calibrated geologic time scales of high accuracy to understand Earth system dynamics. However, the astrophysical models beyond several tens of million years ago have large uncertainty due to chaotic behavior of the Solar System, and its impact on amplitude modulation of multi-Myr-scale orbital variations and consequent climate changes has become the subject of debate. Here we show the geologic constraints on the past chaotic behavior of orbital cycles from early Mesozoic monsoon-related records; the 30-Myr-long lake level records of the lacustrine sequence in Newark-Hartford basins (North America) and 70-Myr-long biogenic silica (BSi) burial flux record of pelagic deep-sea chert sequence in Inuyama area (Japan). BSi burial flux of chert could be considered as proportional to the dissolved Si (DSi) input from chemical weathering on timescales longer than the residence time of DSi ( 100 kyr), because chert could represent a major sink for oceanic dissolved silica (Ikeda et al., 2017).These geologic records show multi-Myr cycles with similar frequency modulations of eccentricity solution of astronomical model La2010d (Laskar et al., 2011) compared with other astronomical solutions, but not exactly same. Our geologic records provide convincing evidence for the past chaotic dynamical behaviour of the Solar System and new and challenging additional constraints for astrophysical models. In addition, we find that ˜10 Myr cycle detected in monsoon proxies and their amplitude modulation of ˜2 Myr cycle may be related to the amplitude modulation of ˜2 Myr eccentricity cycle through non-linear process(es) of Earth system dynamics, suggesting possible impact of the chaotic behavior of Solar planets on climate change. Further impact of multi-Myr orbital cycles on global biogeochemical cycles will be discussed.

  13. New Genotypes of Orientia tsutsugamushi Isolated from Humans in Eastern Taiwan

    PubMed Central

    Lin, Chin-Hui; Chen, Tren-Yi; Chen, Li-Kuang

    2012-01-01

    Scrub typhus, an acute febrile illness, is caused by the obligate intracellular bacterium Orientia tsutsugamushi. In our study, O. tsutsugamushi was rapidly detected and typed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis of the 56-kDa type-specific antigen (TSA) gene. To investigate the genotypes of clinical variants of O. tsutsugamushi, we collected 3223 blood samples from eastern Taiwanese patients with suspected scrub typhus from 2002 to 2008. In total, 505 samples were found to be positive for scrub typhus infection by PCR, and bacteria were isolated from 282 of them. Four prototype genotype strains (Karp, Kato, Kawasaki and Gilliam) and eleven different Taiwanese genotype isolates (Taiwan-A, -B, -C, -D, -E, -G, -H, -J, -N, -O and -P) were identified by RPLF analysis. Taiwan-H, the major genotype in eastern Taiwan, exhibited prevalence and isolation rates of 47.3% (239/505) and 42.6% (120/282), respectively. We also assessed the genetic relatedness of the 56-kDa TSA gene among eight Taiwan-H isolates, thirteen other Taiwanese isolates and 104 DNA sequences deposited in the GenBank database using MEGA version 5.0 and PHYLIP version 3.66. We found that the Taiwan-H isolates formed into a new cluster, which was designated the Taiwan Gilliam-variant (TG-v) cluster to distinguish it from the Japanese Gilliam-variant (JG-v) cluster. According to Simplot analysis, TG-v is a new recombinant strain among Gilliam, Ikeda and Kato. Moreover, the Gilliam-Kawasaki cluster had the highest percentage of RFLP cases and was the most frequently isolated type in eastern Taiwan (50.1%, 253/505; 44.0%, 124/282). These findings shed light on the genetic evolution of O. tsutsugamushi into different strains and may be useful in vaccine development and epidemic disease control in the future. PMID:23071693

  14. Molecular characterization of variant alpha-subunit of electron transfer flavoprotein in three patients with glutaric acidemia type II--and identification of glycine substitution for valine-157 in the sequence of the precursor, producing an unstable mature protein in a patient.

    PubMed Central

    Indo, Y; Glassberg, R; Yokota, I; Tanaka, K

    1991-01-01

    In our previous study of eight glutaric acidemia type II (GAII) fibroblast lines by using [35S]methionine labeling and immunoprecipitation, three of them had a defect in the synthesis of the alpha-subunit of electron transfer flavoprotein (alpha-ETF) (Ikeda et al. 1986). In one of them (YH1313) the labeling of the mature alpha-ETF was barely detectable, while that of the precursor (p) was stronger. In another (YH605) no synthesis of immunoreactive p alpha-ETF was detectable. In the third cell line (YH1391) the rate of variant p alpha-ETF synthesis was comparable to normal, but its electrophoretic mobility was slightly faster than normal. In the present study, the northern blot analysis revealed that all three mutant cell lines contained p alpha-ETF mRNA and that their size and amount were comparable to normal. In immunoblot analysis, both alpha- and beta-ETF bands were barely detectable in YH1313 and YH605 but were detectable in YH1391 in amounts comparable to normal. Sequencing of YH1313 p alpha-ETF cDNA via PCR identified a transversion of T-470 to G. We then devised a simple PCR method for the 119-bp section (T-443/G-561) for detecting this mutation. In the upstream primer, A-466 was artificially replaced with C, to introduce a BstNI site into the amplified copies in the presence of G-470 from the variant sequence. The genomic DNA analysis using this method demonstrated that YH1313 was homozygous for T----G-470 transversion. It was not detected either in two other alpha-ETF-deficient GAII or in seven control cell lines. The alpha-ETF cDNA sequence in YH605 was identical to normal. Images Figure 1 Figure 2 Figure 3 Figure 5 PMID:1882842

  15. Suzaku View of the Swift/BAT Active Galactic Nuclei. V. Torus Structure of Two Luminous Radio-Loud Active Galactic Nuclei (3C 206 and PKS 0707-35)

    NASA Technical Reports Server (NTRS)

    Tazaki, Fumie; Ueda, Yoshihiro; Terashima, Yuichi; Mushotzky, Richard F.; Tombesi, Francesco

    2013-01-01

    We present the results from broadband X-ray spectral analysis of 3C 206 and PKS 0707-35 with Suzaku and Swift/BAT, two of the most luminous unobscured and obscured radio-loud active galactic nuclei (AGNs) with hard X-ray luminosities of 10(sup 45.5) erg per second and 10(sup 44.9) erg per second (14-195 keV), respectively. Based on the radio core luminosity, we estimate that the X-ray spectrum of 3C 206 contains a significant (60% in the 14-195 keV band) contribution from the jet, while it is negligible in PKS 0707-35.We can successfully model the spectra with the jet component (for 3C 206), the transmitted emission, and two reflection components from the torus and the accretion disk. The reflection strengths from the torus are found to be R(sub torus)(=Omega/2pi) = 0.29 +/- 0.18 and 0.41 +/- 0.18 for 3C 206 and PKS 0707-35, respectively, which are smaller than those in typical Seyfert galaxies. Utilizing the torus model by Ikeda et al., we quantify the relation between the half-opening angle of a torus (theta(sub oa)) and the equivalent width of an iron-K line. The observed equivalent width of 3C 206, less than 71 eV, constrains the column density in the equatorial plane to N(sup eq)(sub H) lesst han 10(sup 23) per square centimeter, or the half-opening angle to theta(sub oa) greater than 80 deg. if N(sup eq)(sub H) = 10(sup 24) per square centimeter is assumed. That of PKS 0707-35, 72 +/- 36 eV, is consistent with N(sup eq)(sub H) 10(sup 23) per square centimeter. Our results suggest that the tori in luminous radio-loud AGNs are only poorly developed. The trend is similar to that seen in radio-quiet AGNs, implying that the torus structure is not different between AGNs with jets and without jets.

  16. Application of indexes of underground structure using land gravity data to the Eastern Boundary Fault zone of the Shonai Plain, northeastern Japan.

    NASA Astrophysics Data System (ADS)

    Tanaka, T.; Hiramatsu, Y.; Matsumoto, N.; Honda, R.; Wada, S.; Sawada, A.; Okada, S.

    2016-12-01

    Gravity gradients, which are directly measured and are also derived by differentiating land gravity anomaly data, are sensitive to the density structure of shallow subsurfaces and therefore can be used to formulate ratings for Indexes of Underground Structure (IUS) [e.g., Kusumoto,2015,2016]. Recently, dense land gravity data measurements for almost entire Japan have been available [Honda et al., 2012]. In this study, we use gravity gradient tensors from the data to apply IUS to the Eastern Boundary Fault zone of the Shonai Plain (EBFSP), which spans 40 km in length and caused the historical Mjma 7.0 earthquake in 1894. The IUS we adopt here comprises the dip angle of the structural boundary (Beta) [Beiki, 2013], the dimensionality index (I) [Pedersen and Rasmussen, 1990], the structural boundary (Horizontal First Derivation(HFD) and TDX [Cooper and Cowan, 2006]), and density anomaly cylinder bodies in the depth direction (TD) [Copper, 2011]. The IUS show that the northern part of the EBFSP is characterized by high-Beta, low-I (dyke-like), intense-(HFD and TDX), and many short TD. Contrary to this, the southern part exhibits low-Beta, high-I, mild-(HFD and TDX), and few long TD. Previous geological/geomorphological surveys of the EBFSP [Ikeda et al., 2002] distinguish between the northern part comprising parallel/echelon short faults and the southern part comprising a single long fault. These findings are consistent with the gravimetrical IUS. However, the IUS more emphasizes the Aosawa Fault zone, which is geologically old and runs nearly parallel to the EBFSP at about 5-10 km distance on the eastern side of the EBFSP. Because gravity anomalies are a time-integrated representation of crustal activity, it is difficult to identify the relative timing of faulting events in an analysis range. However, the IUS can objectively contribute to producing comprehensive characterizations of target faults. This study is supported by JSPS KAKENHI Grant Number 26400450.

  17. Elastic strain budget and inelastic deformation in northeast Japan

    NASA Astrophysics Data System (ADS)

    Sagiya, T.; Meneses Gutierrez, A. D. V.

    2016-12-01

    A degree of magnitude discrepancy between geodetic and geologic strain rates of the Japan islands has been debated for a long time. Ikeda (1996) hypothesized that geodetic strain rate is affected by interseismic locking at the plate interface, which was later supported by the occurrence of the 2011 Tohoku-oki earthquake. The hypothesis also predicts that the interseismic elastic strain must be fully released in association with large earthquakes and do not accumulates in time. However, there has been no such quantitative discussion about the elastic strain budget of the Japan Islands so far. A 261 km-long baseline connecting GEONET stations Ryotsu (950232) and Oshika (960550) runs across the northeast Japan in the E-W direction. The baseline length change shows interseismic contraction at 0.11 ppm/yr before 2011, and coseismic extension of about 20 ppm, which comprises only 200 years of interseismic strain. Geologically the recurrence interval of 2011-type giant earthquakes is estimated as 400-800 years, much longer than a prediction from the elastic strain budget. Menese-Gutierrez and Sagiya (2016) recently identified persistent crustal shortening of 4-10 mm/yr along the Japan Sea coastal area from continuous GPS data. This contribution of inelastic deformation corresponds to 10 30% of the total interseismic shortening. The discrepancy can be also partly resolved by considering the effects of M7-class earthquakes and inelastic deformation of the island arc. M7-class earthquakes such as the 1978 and 2005 Miyagi-oki earthquakes cause 0.05-0.10 cm of baseline extension every about 40 years, releasing about 10 % of the totals strain. In addition, a postseismic extension still continues after 5 years from the main shock. By assuming this postseismic phase continues for about 50-100 years, the total elastic strain budget is balanced for a recurrence interval of about 400 yrs. If we assume a longer recurrence interval, we need additional ingredients such as inelastic

  18. Sterylglucoside catabolism in Cryptococcus neoformans with endoglycoceramidase-related protein 2 (EGCrP2), the first steryl-β-glucosidase identified in fungi.

    PubMed

    Watanabe, Takashi; Ito, Tomoharu; Goda, Hatsumi M; Ishibashi, Yohei; Miyamoto, Tomofumi; Ikeda, Kazutaka; Taguchi, Ryo; Okino, Nozomu; Ito, Makoto

    2015-01-09

    Cryptococcosis is an infectious disease caused by pathogenic fungi, such as Cryptococcus neoformans and Cryptococcus gattii. The ceramide structure (methyl-d18:2/h18:0) of C. neoformans glucosylceramide (GlcCer) is characteristic and strongly related to its pathogenicity. We recently identified endoglycoceramidase-related protein 1 (EGCrP1) as a glucocerebrosidase in C. neoformans and showed that it was involved in the quality control of GlcCer by eliminating immature GlcCer during the synthesis of GlcCer (Ishibashi, Y., Ikeda, K., Sakaguchi, K., Okino, N., Taguchi, R., and Ito, M. (2012) Quality control of fungus-specific glucosylceramide in Cryptococcus neoformans by endoglycoceramidase-related protein 1 (EGCrP1). J. Biol. Chem. 287, 368-381). We herein identified and characterized EGCrP2, a homologue of EGCrP1, as the enzyme responsible for sterylglucoside catabolism in C. neoformans. In contrast to EGCrP1, which is specific to GlcCer, EGCrP2 hydrolyzed various β-glucosides, including GlcCer, cholesteryl-β-glucoside, ergosteryl-β-glucoside, sitosteryl-β-glucoside, and para-nitrophenyl-β-glucoside, but not α-glucosides or β-galactosides, under acidic conditions. Disruption of the EGCrP2 gene (egcrp2) resulted in the accumulation of a glycolipid, the structure of which was determined following purification to ergosteryl-3β-glucoside, a major sterylglucoside in fungi, by mass spectrometric and two-dimensional nuclear magnetic resonance analyses. This glycolipid accumulated in vacuoles and EGCrP2 was detected in vacuole-enriched fraction. These results indicated that EGCrP2 was involved in the catabolism of ergosteryl-β-glucoside in the vacuoles of C. neoformans. Distinct growth arrest, a dysfunction in cell budding, and an abnormal vacuole morphology were detected in the egcrp2-disrupted mutants, suggesting that EGCrP2 may be a promising target for anti-cryptococcal drugs. EGCrP2, classified into glycohydrolase family 5, is the first steryl

  19. Stopped-flow kinetic studies of sphere-to-rod transitions of sodium alkyl sulfate micelles induced by hydrotropic salt.

    PubMed

    Zhang, Jingyan; Ge, Zhishen; Jiang, Xiaoze; Hassan, P A; Liu, Shiyong

    2007-12-15

    The kinetics and mechanism of sphere-to-rod transitions of sodium alkyl sulfate micelles induced by hydrotropic salt, p-toluidine hydrochloride (PTHC), were investigated by stopped-flow with light scattering detection. Spherical sodium dodecyl sulfate (SDS) micelles transform into short ellipsoidal shapes at low salt concentrations ([PTHC]/[SDS], chi(PTHC)=0.3 and 0.4). Upon stopped-flow mixing aqueous solutions of spherical SDS micelles with PTHC, the scattered light intensity gradually increases with time. Single exponential fitting of the dynamic traces leads to characteristic relaxation time, tau(g), for the growth process from spherical to ellipsoidal micelles, and it increases with increasing SDS concentrations. This suggests that ellipsoidal micelles might be produced by successive insertion of unimers into spherical micelles, similar to the case of formation of spherical micelles as suggested by Aniansson-Wall (A-W) theory. At chi(PTHC) > or = 0.5, rod-like micelles with much higher axial ratio form. The scattered light intensity exhibits an initially abrupt increase and then levels off. The dynamic curves can be well fitted with single exponential functions, and the obtained tau(g) decreases with increasing SDS concentration. Thus, the growth from spherical to rod-like micelles might proceed via fusion of spherical micelles, in agreement with mechanism proposed by Ikeda et al. At chi(PTHC)=0.3 and 0.6, the apparent activation energies obtained from temperature dependent kinetic studies for the micellar growth are 40.4 and 3.6 kJ/mol, respectively. The large differences between activation energies for the growth from spherical to ellipsoidal micelles at low chi(PTHC) and the sphere-to-rod transition at high chi(PTHC) further indicate that they should follow different mechanisms. Moreover, the sphere-to-rod transition kinetics of sodium alkyl sulfate with varying hydrophobic chain lengths (n=10, 12, 14, and 16) are also studied. The longer the carbon chain

  20. Conditional nonlinear optimal perturbations based on the particle swarm optimization and their applications to the predictability problems

    NASA Astrophysics Data System (ADS)

    Zheng, Qin; Yang, Zubin; Sha, Jianxin; Yan, Jun

    2017-02-01

    In predictability problem research, the conditional nonlinear optimal perturbation (CNOP) describes the initial perturbation that satisfies a certain constraint condition and causes the largest prediction error at the prediction time. The CNOP has been successfully applied in estimation of the lower bound of maximum predictable time (LBMPT). Generally, CNOPs are calculated by a gradient descent algorithm based on the adjoint model, which is called ADJ-CNOP. This study, through the two-dimensional Ikeda model, investigates the impacts of the nonlinearity on ADJ-CNOP and the corresponding precision problems when using ADJ-CNOP to estimate the LBMPT. Our conclusions are that (1) when the initial perturbation is large or the prediction time is long, the strong nonlinearity of the dynamical model in the prediction variable will lead to failure of the ADJ-CNOP method, and (2) when the objective function has multiple extreme values, ADJ-CNOP has a large probability of producing local CNOPs, hence making a false estimation of the LBMPT. Furthermore, the particle swarm optimization (PSO) algorithm, one kind of intelligent algorithm, is introduced to solve this problem. The method using PSO to compute CNOP is called PSO-CNOP. The results of numerical experiments show that even with a large initial perturbation and long prediction time, or when the objective function has multiple extreme values, PSO-CNOP can always obtain the global CNOP. Since the PSO algorithm is a heuristic search algorithm based on the population, it can overcome the impact of nonlinearity and the disturbance from multiple extremes of the objective function. In addition, to check the estimation accuracy of the LBMPT presented by PSO-CNOP and ADJ-CNOP, we partition the constraint domain of initial perturbations into sufficiently fine grid meshes and take the LBMPT obtained by the filtering method as a benchmark. The result shows that the estimation presented by PSO-CNOP is closer to the true value than the

  1. Metabolic engineering of an ATP-neutral Embden-Meyerhof-Parnas pathway in Corynebacterium glutamicum: growth restoration by an adaptive point mutation in NADH dehydrogenase.

    PubMed

    Komati Reddy, Gajendar; Lindner, Steffen N; Wendisch, Volker F

    2015-03-01

    Corynebacterium glutamicum uses the Embden-Meyerhof-Parnas pathway of glycolysis and gains 2 mol of ATP per mol of glucose by substrate-level phosphorylation (SLP). To engineer glycolysis without net ATP formation by SLP, endogenous phosphorylating NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was replaced by nonphosphorylating NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (GapN) from Clostridium acetobutylicum, which irreversibly converts glyceraldehyde-3-phosphate (GAP) to 3-phosphoglycerate (3-PG) without generating ATP. As shown recently (S. Takeno, R. Murata, R. Kobayashi, S. Mitsuhashi, and M. Ikeda, Appl Environ Microbiol 76:7154-7160, 2010, http://dx.doi.org/10.1128/AEM.01464-10), this ATP-neutral, NADPH-generating glycolytic pathway did not allow for the growth of Corynebacterium glutamicum with glucose as the sole carbon source unless hitherto unknown suppressor mutations occurred; however, these mutations were not disclosed. In the present study, a suppressor mutation was identified, and it was shown that heterologous expression of udhA encoding soluble transhydrogenase from Escherichia coli partly restored growth, suggesting that growth was inhibited by NADPH accumulation. Moreover, genome sequence analysis of second-site suppressor mutants that were able to grow faster with glucose revealed a single point mutation in the gene of non-proton-pumping NADH:ubiquinone oxidoreductase (NDH-II) leading to the amino acid change D213G, which was shared by these suppressor mutants. Since related NDH-II enzymes accepting NADPH as the substrate possess asparagine or glutamine residues at this position, D213G, D213N, and D213Q variants of C. glutamicum NDH-II were constructed and were shown to oxidize NADPH in addition to NADH. Taking these findings together, ATP-neutral glycolysis by the replacement of endogenous NAD-dependent GAPDH with NADP-dependent GapN became possible via oxidation of NADPH formed in this pathway by mutant NADPH

  2. Multiscale plant wakes, turbulence and non linear scaling flexible effects

    NASA Astrophysics Data System (ADS)

    Vila, Teresa; Redondo, Jose M.; Velasco, David

    2010-05-01

    We present velocity ADV measurements and flow visualization of the turbulent wakes behind plant arrays, as these are often fractal in nature, we compare the multifractal spectra and the turbulence structure behind the wakes. Both statistical measures allowing to calculate integral lengthscales and their profiles modified by the plant cannopies [1,2] as well as intermittency and spectral behaviour are also measured [3,4]. We distinguish several momentum transfer mechanisms between the cannopy and the flow, an internal one where lateral turbulent tensions are dominant, and another one just above the plant average height dominated by vertical Reynolds stresses. Visualization of flow over individual plant models show the role of coherent vortices triggered by plant elasticity. The deformation rate of the plants and their Youngs modulus may be correlated with overal plant drag and geometry. This is modified strongly in fractal canopies. Large turbulent integral scales are linked to rugosity and the scaling of the waves.[5,6] Pearlescence experiments where local shear is visualized and numerical simulations of Fractal grids are compared following [7]. [1] Nepf,H.M. Drag, turbulence and diffusion in flow through emergent vegetation. Water Resources Res. 35(2)(1999) [2] Ben Mahjoub,O., Redondo J.M. and Babiano A. Jour.Structure functions in complex flows. Flow Turbulence and Combustion 59, 299-313. [3] El-Hakim, O. Salama, M. Velocity distribution inside and above branched flexible roughness. ASCE Journal of Irrigation and Drainage Engineering, Vol. 118, No 6, (November/December 1992) 914-927. [4] Finnigan,J. Turbulence in plant canopies. Annu. Rev. Fluid Mech. 2000 , Vol. 32: 519-571. [5] Ikeda, S., Kanazawa, M. Three- dimensional organized vortices above flexible water plants. ASCE Journal of Hydraulic Engineering, Vol. 122, No 11, (1996) 634-640. [6] Velasco, D.,Bateman A.,Redondo J.M and Medina V. An open channel flow experimental and theorical study of resistance and

  3. Diagnostic Accuracy of the FIGO and the 5-Tier Fetal Heart Rate Classification Systems in the Detection of Neonatal Acidemia.

    PubMed

    Martí Gamboa, Sabina; Giménez, Olga Redrado; Mancho, Jara Pascual; Moros, María Lapresta; Sada, Julia Ruiz; Mateo, Sergio Castan

    2017-04-01

    Objective  The objective of this study was to determine ability to detect neonatal acidemia and interobserver agreement with the FIGO 3-tier and 5-tier fetal heart rate (FHR) classification systems. Design  This was a case-control study. Setting  This study was set at the University Medical Center. Population  A total of 202 FHR tracings of 102 women who delivered an acidemic fetus (umbilical arterial cord gas pH ≤ 7.10 and BE < - 8) and 100 who delivered a nonacidemic fetus (umbilical arterial cord gas pH > 7.10) were assessed. A subanalysis was performed for those fetuses who suffered severe metabolic acidemia (pH ≤ 7.0 and BE < - 12). Methods  Two reviewers blind to clinical and outcome data classified tracings according to the new 3-tier system proposed by the FIGO and the 5-tier system proposed by Parer and Ikeda. Main Outcome Measures  Sensitivity and specificity for detecting neonatal acidemia and interobserver agreement in classifying FHR tracings into categories of both systems were studied. Results  The 3-tier system showed a greater sensitivity and lower specificity to detect neonatal acidemia (43.6% sensitivity, 82.5% specificity) and severe metabolic acidemia (71.4% sensitivity, 74.0% specificity) compared with the 5-tier system (36.3% sensitivity, 88% specificity and 61.9% sensitivity, 80.1% specificity, respectively). Both systems were compared by area under the receiver-operating characteristic curve, with comparable predictive ability for detecting neonatal acidemia (FIGO-area under the curve [AUC]: 0.63 [95% confidence interval [CI]: 0.57-0.68] and Parer-AUC: 0.62 [95% CI: 0.56-0.67]). Interobserver agreement was moderate for both systems, but performance at each specific category showed a better agreement for the 5-tier system identifying a pathological tracing (orange or red, κ: 0.625 vs. pathological category, κ: 0.538). Conclusion  Both systems presented a comparable ability to predict neonatal acidemia

  4. Thz Spectroscopy of 13C Isotopic Species of a "weed": Acetaldehyde

    NASA Astrophysics Data System (ADS)

    Margulès, L.; Motiyenko, R. A.; Guillemin, J.-C.

    2011-06-01

    Our studies of the isotopic species of 13C and D isotopologues of methyl formate (HCOOCH_3), have allowed the detection of more than 600 lines in Orion. This confirms that many observed U-lines are coming from isotopic species of one of the most abundant molecules in space. Since its first detection in 1976 in SgrB2 and in Orion A, acetaldehyde (CH_3CHO) was detected in many other numerous objects. If its deuterated species (CD_3CHO and CH_3CDO) have been previously studied in the millimeterwave range, the data concerning the 13C species are limited to few lines measured in 1957 up to 40 GHz. In this context we decided to study the 13C species of acetaldehyde. Acetaldehyde molecule displays a large amplitude motion: the hindered rotation of the methyl group with respect to the rest of the molecule. The analysis is performed with the Rho Axis Method. Recent versions of the codes include high orders term in order to reproduce the observed frequencies for large quantum numbers values as J-values as high as 70a,b,. Measurements and analysis of the rotational spectra of 13C isotopic species are in progress in Lille with a solid-state submillimetre-wave spectrometer (50-950 GHz), the first results will be presented. This work is supported by the contract ANR-08-BLAN-0054 and by the Programme National de Physico-Chimie du Milieu Interstellaire (PCMI-CNRS). Carvajal, M.; Margulès, L.; Tercero, B.; et al.A&A 500, (2009) 1109 Margulès, L.; Huet, T. R.; Demaison J.; et al.,ApJ 714, (2010) 1120. Ikeda, M.; Ohishi, M.; Nummelin, A.; et al., ApJ, 560, (2001) 792 Kleiner, I.; Lopez, J.-C.; Blanco, S.; et al.J. Mol. Spectrosc. 197, (1999) 275 Elkeurti M.; Coudert, L. H.; Medvedev, I. R.; et al.J. Mol. Spectrosc. 263, (2010) 145 Kilb, R.W.; Lin, C.C.; and Wilson, E.B.J. Chem. Phys. 26, (1957) 1695 Kleiner, I. J. Mol. Spectrosc. 260, (2010) 1 Ilyushin, V.V.; Kryvda, A; and Alekseev, E;J. Mol. Spectrosc. 255, (2009) 32

  5. Advances in the evaluation of wind-induced undercatch using CFD-based simulations of snow gauge performance

    NASA Astrophysics Data System (ADS)

    Colli, Matteo; Lanza, Luca; Rasmussen, Roy; Thériault, Julie

    2016-04-01

    Hydrometeorol., 17(1), pages 231-243. Colli, M., Lanza, L.G., Rasmussen, R.M. and J.M. Thèriault (2016b). The collection efficiency of shielded and unshielded precipitation gauges. Part II: modelling particle trajectories. J. of Hydrometeorol., 17(1), 245-255. Thériault, J. M., R. Rasmussen, K. Ikeda, and S. Landolt, (2012). Dependence of snow gauge collection efficiency on snowflake characteristics. J. Appl. Meteor. Climatol., 51, 745-762.

  6. Three-dimensional Numerical Simulation of Venus' Cloud-level Convection

    NASA Astrophysics Data System (ADS)

    Sugiyama, K. I.; Nakajima, K.; Odaka, M.; Imamura, T.; Hayashi, Y. Y.; Ishiwatari, M.; Kawabata, T.

    2015-12-01

    Although some observational evidences have suggested the occurrence of convection in the lower part of Venus' cloud layer, its structure remains to be clarified. To date, a few numerical studies have examined the structure of convective motion (Baker et al., 1998, 2000; Imamura et al., 2014), but the model they utilized is two-dimensional. Here we report on the results of our numerical calculations performed in order to investigate possible three-dimensional structure of the convection. We use a convection resolving model developed by Sugiyama et al. (2009), which is used in the simulations of the atmospheric convection of Jupiter (Sugiyama et al., 2011,2014) and Mars (Yamashita et al., submitted). We perform two experiments. The first one, which we call Ext.B, is based on Baker et al. (1998). A constant turbulent mixing coefficient is used in the whole domain, and a constant thermal flux is given at the upper and lower boundaries as a substitute for infrared heating. The second one, which we call Exp.I, is based on Imamura et al. (2014). The sub-grid turbulence process is implemented by Klemp and Wilhelmson (1989), and an infrared heating profile obtained in a radiative-convective equilibrium calculation (Ikeda, 2011) is used. In both experiments, the averaged solar heating profile is used. The spatial resolution is 200 m in the horizontal direction and 125 m in the vertical direction. The domain covers 128km x 128km horizontally and altitudes from 40 km to 60 km. Obtained structures of convection moderately differ in the two experiments. Although the depth of convection layer is almost the same, the horizontal cell size of Exp.B is larger than that of Exp.I; the cell sizes in Exp.B and Exp.I are about 40 km and 25 km, respectively. The vertical motion in Exp.B is asymmetric; updrafts are widespread and weak (~3m/s), whereas downdrafts are narrow and strong (~10m/s). On the other hand, the vertical motion in Exp.I is nearly symmetric and weaker (~2m/s) compared

  7. Computer simulations of channel meandering and the formation of point bars: Linking channel dynamics to the preserved stratigraphy

    NASA Astrophysics Data System (ADS)

    Sun, T.; Covault, J. A.; Pyrcz, M.; Sullivan, M.

    2012-12-01

    Meandering rivers are probably one of the most recognizable geomorphic features on earth. As they meander across alluvial and delta plains, channels migrate laterally and develop point bars, splays, levees and other geomorphic and sedimentary features that compose substantial portions of the fill within many sedimentary basins. These basins can include hydrocarbon producing fields. Therefore, a good understanding of the processes of meandering channels and their associated deposits is critical for exploiting these reservoirs in the subsurface. In the past couple of decades, significant progress has been made in our understanding of the morphodynamics of channel meandering. Basic fluid dynamics and sediment transport (Ikeda and Parker, 1981; Howard, 1992) has shown that many characteristic features of meandering rivers, such as the meandering wavelength, growth rate and downstream migration rate, can be predicted quantitatively. As a result, a number of variations and improvement of the theory have emerged (e.g., Blondeaux and Seminara, 1985; Parker and Andrews, 1985, 1986; and Sun et al., 2001a, b).The main improvements include the recognition of so called "bar-bend" interactions, where the development of bars on the channel bed and their interactions with the channel bend is recognized as a primary cause for meandering channels to develop greater complexity than the classic goose-neck meander bend shapes, such as compound bend. Recently, Sun and others have shown that the spatial patterns of width variations in meandering channels can be explained by an extrinsic periodic flow variations coupled with the intrinsic bend instability dynamics. In contrast to the significant improvement of our understanding of channel meandering, little work has been done to link the geomorphic features of meandering channels to the geometry and heterogeneity of the deposits they form and ultimately preserves. A computer simulation model based on the work of Sun and others (1996, 2001

  8. An initial event in the insect innate immune response: structural and biological studies of interactions between β-1,3-glucan and the N-terminal domain of β-1,3-glucan recognition protein.

    PubMed

    Dai, Huaien; Hiromasa, Yasuaki; Takahashi, Daisuke; VanderVelde, David; Fabrick, Jeffrey A; Kanost, Michael R; Krishnamoorthi, Ramaswamy

    2013-01-08

    In response to invading microorganisms, insect β-1,3-glucan recognition protein (βGRP), a soluble receptor in the hemolymph, binds to the surfaces of bacteria and fungi and activates serine protease cascades that promote destruction of pathogens by means of melanization or expression of antimicrobial peptides. Here we report on the nuclear magnetic resonance (NMR) solution structure of the N-terminal domain of βGRP (N-βGRP) from Indian meal moth (Plodia interpunctella), which is sufficient to activate the prophenoloxidase (proPO) pathway resulting in melanin formation. NMR and isothermal calorimetric titrations of N-βGRP with laminarihexaose, a glucose hexamer containing β-1,3 links, suggest a weak binding of the ligand. However, addition of laminarin, a glucose polysaccharide (~6 kDa) containing β-1,3 and β-1,6 links that activates the proPO pathway, to N-βGRP results in the loss of NMR cross-peaks from the backbone (15)N-(1)H groups of the protein, suggesting the formation of a large complex. Analytical ultracentrifugation (AUC) studies of formation of the N-βGRP-laminarin complex show that ligand binding induces self-association of the protein-carbohydrate complex into a macro structure, likely containing six protein and three laminarin molecules (~102 kDa). The macro complex is quite stable, as it does not undergo dissociation upon dilution to submicromolar concentrations. The structural model thus derived from this study for the N-βGRP-laminarin complex in solution differs from the one in which a single N-βGRP molecule has been proposed to bind to a triple-helical form of laminarin on the basis of an X-ray crystallographic structure of the N-βGRP-laminarihexaose complex [Kanagawa, M., Satoh, T., Ikeda, A., Adachi, Y., Ohno, N., and Yamaguchi, Y. (2011) J. Biol. Chem. 286, 29158-29165]. AUC studies and phenoloxidase activation measurements conducted with the designed mutants of N-βGRP indicate that electrostatic interactions involving Asp45, Arg54

  9. Superquakes and Supercycles

    NASA Astrophysics Data System (ADS)

    Goldfinger, C.; Ikeda, Y.; Yeats, R. S.

    2011-12-01

    The recent Mw=9 superquake off Tohoku Japan, and the 2004 Sumatra-Andaman superquake have humbled many in earthquake research. Neither region was thought capable of earthquakes of magnitudes exceeding Mw~8.4 based on historical records and theories based on short instrumental records. In NE Japan, horizontal shortening is ~5-7 mm/yr. based on faulting and regional uplift data. On the Pacific coast, high rates of subsidence from tide gauges, and geodetic observations revealed E-W contraction at several tens of mm/yr. Only a fraction (< 10%) of plate convergence is inelastic. The elastic rate is ~ an order of magnitude greater than the geologic rate, and is comparable to convergence at the Trench. These data strongly suggested that the strain must be released periodically in earthquakes stronger than those in the historical record (Ikeda, 2003). The Jogan tsunami of 869 is a likely equivalent to the 2011 earthquake, and had two predecessors at ~ 1000 year intervals (Minoura et al., 2001; Shishikura et al., 2007). A related example is the Haiyuan fault, China, the source of an earthquake in 1920 with a rupture length of 237 km. Paleoseismic trenching divided the 1920 rupture into three segments and dated surface-rupturing earthquakes in the past 6000 yrs. Some earthquakes ruptured one segment, some ruptured two, but only one (6100-6200 yrs BP) ruptured all three segments and was a likely duplicate of 1920 (Ran et al. 1997). Prior to trenching, there was a tendency to regard the 1920 earthquake as the characteristic earthquake, when the majority of the paleoseismic examples were much smaller. The two largest events had much greater net slip (5.6 and 7.0 m respectively for ~6150 BP and AD 1920) than the intervening events which averaged 1.5-2 m. In Cascadia, a 10ka paleoseismic record includes evidence of segmented ruptures, clustering, and several outsized events. Goldfinger et al. (2011) compared the mass of correlated turbidite deposits along strike, and found strong

  10. EDITORIAL: Fluctuations and noise in photonics and quantum optics: a special issue in memory of Hermann Haus

    NASA Astrophysics Data System (ADS)

    Abbott, Derek; Shapiro, Jeffrey H.; Yamamoto, Yoshihisa

    2004-08-01

    dedicated this Special Issue to him. The first item is an obituary reflecting on his life and work. The first technical paper in this issue represents Hermann’s last sole author publication; a special thanks is due to A P Flitney for organizing this manuscript into publishable form. We thank the members of the International Programme Committee, listed below, and all those who contributed to making the event such a success. At this point we take the opportunity to express our gratitude to both the authors and reviewers, for their unfailing efforts in preparing and ensuring the high quality of the papers in this Special Issue. International Programme Committee David A Cardimona Air Force Research Laboratory, USA Howard Carmichael University of Auckland, New Zealand Carlton M Caves University of New Mexico, Albuquerque, USA Peter D Drummond University of Queensland, St Lucia, Australia Paul J Edwards University of Canberra, Australia Luca Gammaitoni Università degli Studi di Perugia, Italy Brage Golding Michigan State University, East Lansing, USA Gabriela Gonzalez Louisiana State University, Baton Rouge, USA Guangcan Guo University of Science and Technology of China, Hefei, China Salman Habib Los Alamos National Laboratory, NM, USA Murray Hamilton University of Adelaide, Australia Bei-Lok Hu University of Maryland/College Park, USA Daniel K Johnstone Virginia Commonwealth University, Richmond, USA Franz X Kärtner Massachusetts Institute of Technology, Cambridge, USA Prem Kumar Northwestern University, Evanston, IL, USA Zachary Lemnios DARPA, Arlington, VA, USA Gerd Leuchs Friedrich-Alexander Universität Erlangen--Nürnberg, Germany Hideo Mabuchi California Institute of Technology, Pasadena, USA Peter W Milonni Los Alamos National Laboratory, NM, USA Adrian C Ottewill University College Dublin, Ireland Martin B Plenio Imperial College, London, UK Rajeev J Ram Massachusetts Institute of Technology, Cambridge, USA Farhan Rana Massachusetts Institute of Technology, Cambridge

  11. Earthquake Recurrence along the Kuril Trench: A New View from Paleoseismology

    NASA Astrophysics Data System (ADS)

    Satake, K.; Nanayama, F.

    2003-12-01

    Paleoseismological data along the Pacific coast of eastern Hokkaido indicate that unusual earthquakes have repeated at about 500 year interval with the most recent event in the 17th century. Along the Kuril trench, interplate earthquakes with rupture length of 100-200 km occurred in 1952 (Mw 8.1) and 1973 (Mw 7.8), as well as 1843 (M 8.0) and 1894 (M 7.9), which have been considered characteristics of this subduction zone. We review paleoseismological data, examine coastal deformation and tsunami inundation from fault models, and propose a model of earthquake recurrence in the Kuril subduction zone. Pleistocene marine terraces on the Pacific coast show slight net uplift, at an average of 0.1-0.4 mm/yr in the past several hundred thousand years, whereas tide-gauge data show gradual subsidence of 8-9 mm/yr since 1900. Infrequent unusual event (Armageddon) has been inferred (Ikeda, 1996) to resolve this conflict. Holocene stratigraphic and microfossil studies have indicated sea-level changes in the last 3 ka (e.g., Sawai, 2001). Each event is marked by an abrupt upward change from brackish bay deposits to freshwater peat. The youngest change has been dated in the 17th century with an estimated uplift amount of 0.5-1m (Atwater et al., 2003). Such evidence has been found along the 100 km long coast and recurred up to seven times in the last 2.5 ka (Kelsey et al., 2002). Extensive tsunami deposits indicate large prehistoric tsunamis (Nanayama et al., 2003). At Kiritappu, for instance, sand sheets extend 3 km inland, much further than historic tsunamis. Ten sheets of tsunami deposits indicate recurrence of such unusual tsunami with an average recurrence interval of about 500 years. The most recent event occurred in the 17th century. Historic documents in Honshu rules out unusual tsunamis that would cause damage along the Sanriku coast. Tsunami damage from the 1611 and 1677 earthquakes, both along the Japan trench, have been documented along the Sanriku coast. We modeled

  12. PREFACE: 7th International Conference on Applications of Physics in Financial Analysis

    NASA Astrophysics Data System (ADS)

    Takayasu, M.; Watanabe, T.; Ikeda, Y.; Takayasu, H.

    2010-04-01

    become interested in such datasets, conducting empirical investigations about various aspects of economic activities. Specifically, they have searched for regularities and 'laws' akin to the ones in natural science, successfully producing fascinating results, as shown in the papers contained in this volume. Each paper submitted for publication in this volume has gone through the refereeing process, and has been revised on the basis of comments and discussion at the conference as well as comments from the anonymous referees. Finally, 19 papers were accepted for publication. The editors are very grateful to the colleagues involved in the refereeing process for their rapid and careful reviewing of the papers. We thank Takayuki Mizuno, Koji Sakai, Hiwon Yoon and Hiroki Matsui for their support for the conference. We appreciate the administrative assistance provided by Yayoi Hatano of Hitotsubashi University, and Masahiko Ozaki, Masato Yamada and Tomoko Kase of RIETI. We are most grateful to the authors for their contributions, as well as to the participants, all of whom made this conference stimulating and enjoyable. Misako Takayasu Tokyo Institute of Technology, Japan Tsutomu Watanabe Hitotsubashi University, Japan RIETI, Japan Yuichi Ikeda Hitachi Research Laboratory, Hitachi Ltd, Japan Hideki Takayasu Sony Computer Science Laboratories, Inc, Japan

  13. Quantum Chaos

    NASA Astrophysics Data System (ADS)

    Casati, Giulio; Chirikov, Boris

    2006-11-01

    Preface; Acknowledgments; Introduction: 1. The legacy of chaos in quantum mechanics G. Casati and B. V. Chirikov; Part I. Classical Chaos and Quantum Localization: 2. Stochastic behaviour of a quantum pendulum under a periodic perturbation G. Casati, B. V. Chirikov, F. M. Izrailev and J. Ford; 3. Quantum dynamics of a nonintegrable system D. R. Grempel, R. E. Prange and S. E. Fishman; 4. Excitation of molecular rotation by periodic microwave pulses. A testing ground for Anderson localization R. Blümel, S. Fishman and U. Smilansky; 5. Localization of diffusive excitation in multi-level systems D. K. Shepelyansky; 6. Classical and quantum chaos for a kicked top F. Haake, M. Kus and R. Scharf; 7. Self-similarity in quantum dynamics L. E. Reichl and L. Haoming; 8. Time irreversibility of classically chaotic quantum dynamics K. Ikeda; 9. Effect of noise on time-dependent quantum chaos E. Ott, T. M. Antonsen Jr and J. D. Hanson; 10. Dynamical localization, dissipation and noise R. F. Graham; 11. Maximum entropy models and quantum transmission in disordered systems J.-L. Pichard and M. Sanquer; 12. Solid state 'atoms' in intense oscillating fields M. S. Sherwin; Part II. Atoms in Strong Fields: 13. Localization of classically chaotic diffusion for hydrogen atoms in microwave fields J. E. Bayfield, G. Casati, I. Guarneri and D. W. Sokol; 14. Inhibition of quantum transport due to 'scars' of unstable periodic orbits R. V. Jensen, M. M. Sanders, M. Saraceno and B. Sundaram; 15. Rubidium Rydberg atoms in strong fields G. Benson, G. Raithel and H. Walther; 16. Diamagnetic Rydberg atom: confrontation of calculated and observed spectra C.-H. Iu, G. R. Welch, M. M. Kash, D. Kleppner, D. Delande and J. C. Gay; 17. Semiclassical approximation for the quantum states of a hydrogen atom in a magnetic field near the ionization limit M. Y. Kuchiev and O. P. Sushkov; 18. The semiclassical helium atom D. Wintgen, K. Richter and G. Tanner; 19. Stretched helium: a model for quantum chaos

  14. Quantum Chaos

    NASA Astrophysics Data System (ADS)

    Casati, Giulio; Chirikov, Boris

    1995-04-01

    Preface; Acknowledgments; Introduction: 1. The legacy of chaos in quantum mechanics G. Casati and B. V. Chirikov; Part I. Classical Chaos and Quantum Localization: 2. Stochastic behaviour of a quantum pendulum under a periodic perturbation G. Casati, B. V. Chirikov, F. M. Izrailev and J. Ford; 3. Quantum dynamics of a nonintegrable system D. R. Grempel, R. E. Prange and S. E. Fishman; 4. Excitation of molecular rotation by periodic microwave pulses. A testing ground for Anderson localization R. Blümel, S. Fishman and U. Smilansky; 5. Localization of diffusive excitation in multi-level systems D. K. Shepelyansky; 6. Classical and quantum chaos for a kicked top F. Haake, M. Kus and R. Scharf; 7. Self-similarity in quantum dynamics L. E. Reichl and L. Haoming; 8. Time irreversibility of classically chaotic quantum dynamics K. Ikeda; 9. Effect of noise on time-dependent quantum chaos E. Ott, T. M. Antonsen Jr and J. D. Hanson; 10. Dynamical localization, dissipation and noise R. F. Graham; 11. Maximum entropy models and quantum transmission in disordered systems J.-L. Pichard and M. Sanquer; 12. Solid state 'atoms' in intense oscillating fields M. S. Sherwin; Part II. Atoms in Strong Fields: 13. Localization of classically chaotic diffusion for hydrogen atoms in microwave fields J. E. Bayfield, G. Casati, I. Guarneri and D. W. Sokol; 14. Inhibition of quantum transport due to 'scars' of unstable periodic orbits R. V. Jensen, M. M. Sanders, M. Saraceno and B. Sundaram; 15. Rubidium Rydberg atoms in strong fields G. Benson, G. Raithel and H. Walther; 16. Diamagnetic Rydberg atom: confrontation of calculated and observed spectra C.-H. Iu, G. R. Welch, M. M. Kash, D. Kleppner, D. Delande and J. C. Gay; 17. Semiclassical approximation for the quantum states of a hydrogen atom in a magnetic field near the ionization limit M. Y. Kuchiev and O. P. Sushkov; 18. The semiclassical helium atom D. Wintgen, K. Richter and G. Tanner; 19. Stretched helium: a model for quantum chaos

  15. Mesoscale eddies in the Gulf of Aden and their impact on the spreading of Red Sea Outflow Water

    NASA Astrophysics Data System (ADS)

    Bower, Amy S.; Furey, Heather H.

    2012-04-01

    anticyclonic eddies are added to the previously identified Gulf of Aden Eddy (GAE; Prasad and Ikeda, 2001) and Somali Current Ring (SCR; Fratantoni et al., 2006). These are the Summer Eddy (SE) and the Lee Eddy (LE), both of which form at the beginning of the summer monsoon when strong southwest winds blowing through Socotra Passage effectively split the GAE into two smaller eddies. The SE strengthens as it propagates westward deeper in the GOA, while the Lee Eddy remains stationary in the lee of Socotra Island. Both eddies are strengthened or sustained by Ekman convergence associated with negative wind stress curl patches caused by wind jets through or around high orography. The annual cycle in the appearance, propagation and demise of these new eddies and those described in earlier work is documented to provide a comprehensive view of the most energetic circulation features in the GOA. The observations contain little evidence of features that have been shown previously to be important in the spreading of Mediterranean Outflow Water (MOW) in the North Atlantic, namely a wall-bounded subsurface jet (the Mediterranean Undercurrent) and submesoscale coherent lenses containing a core of MOW (‘meddies’). This is attributed to the fact that the RSOW enters the open ocean on a western boundary. High background eddy kinetic energy typical of western boundary regimes will tend to shear apart submesoscale eddies and boundary undercurrents. Even if a submesoscale lens of RSOW did form in the GOA, westward self-propagation would transport the eddy and its cargo of outflow water back toward, rather than away from, its source.

  16. Cognitive and Behavioral Skills Exercises Completed by Patients with Major Depression During Smartphone Cognitive Behavioral Therapy: Secondary Analysis of a Randomized Controlled Trial.

    PubMed

    Furukawa, Toshi A; Horikoshi, Masaru; Fujita, Hirokazu; Tsujino, Naohisa; Jinnin, Ran; Kako, Yuki; Ogawa, Sei; Sato, Hirotoshi; Kitagawa, Nobuki; Shinagawa, Yoshihiro; Ikeda, Yoshio; Imai, Hissei; Tajika, Aran; Ogawa, Yusuke; Akechi, Tatsuo; Yamada, Mitsuhiko; Shimodera, Shinji; Watanabe, Norio; Inagaki, Masatoshi; Hasegawa, Akio

    2018-01-11

    tasks, engaged in different types of activities, and also filled in more cognitive restructuring worksheets than the latter. Activities such as "test-drive a new car," "go to a coffee shop after lunch," or "call up an old friend" were found to be particularly rewarding. All cognitive restructuring strategies were found to significantly decrease the distress level, with "What would be your advice to a friend who has a similar problem?" found more helpful than some other strategies. The CBT program offered via smartphone and connected to the remote server is not only effective in alleviating depression but also opens a new avenue in gathering information of what and how each participant may utilize the program. The activities and strategies found useful in this analysis will provide valuable information in brush-ups of the program itself and of mobile health (mHealth) in general. Japanese Clinical Trials Registry UMIN CTR 000013693; https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ ctr_view.cgi?recptno=R000015984 (Archived by WebCite at http://www.webcitation.org/6u6pxVwik). ©Toshi A Furukawa, Masaru Horikoshi, Hirokazu Fujita, Naohisa Tsujino, Ran Jinnin, Yuki Kako, Sei Ogawa, Hirotoshi Sato, Nobuki Kitagawa, Yoshihiro Shinagawa, Yoshio Ikeda, Hissei Imai, Aran Tajika, Yusuke Ogawa, Tatsuo Akechi, Mitsuhiko Yamada, Shinji Shimodera, Norio Watanabe, Masatoshi Inagaki, Akio Hasegawa. Originally published in JMIR Mental Health (http://mental.jmir.org), 11.01.2018.

  17. Opening Address

    NASA Astrophysics Data System (ADS)

    Yamada, T.

    2014-12-01

    Ladies and Gentlemen, it is my great honor and pleasure to present an opening address of the 3rd International Workshop on "State of the Art in Nuclear Cluster Physics"(SOTANCP3). On the behalf of the organizing committee, I certainly welcome all your visits to KGU Kannai Media Center belonging to Kanto Gakuin University, and stay in Yokohama. In particular, to whom come from abroad more than 17 countries, I would appreciate your participations after long long trips from your homeland to Yokohama. The first international workshop on "State of the Art in Nuclear Cluster Physics", called SOTANCP, was held in Strasbourg, France, in 2008, and the second one was held in Brussels, Belgium, in 2010. Then the third workshop is now held in Yokohama. In this period, we had the traditional 10th cluster conference in Debrecen, Hungary, in 2012. Thus we have the traditional cluster conference and SOTANCP, one after another, every two years. This obviously shows our field of nuclear cluster physics is very active and flourishing. It is for the first time in about 10 years to hold the international workshop on nuclear cluster physics in Japan, because the last cluster conference held in Japan was in Nara in 2003, about 10 years ago. The president in Nara conference was Prof. K. Ikeda, and the chairpersons were Prof. H. Horiuchi and Prof. I. Tanihata. I think, quite a lot of persons in this room had participated at the Nara conference. Since then, about ten years passed. So, this workshop has profound significance for our Japanese colleagues. The subjects of this workshop are to discuss "the state of the art in nuclear cluster physics" and also discuss the prospect of this field. In a couple of years, we saw significant progresses of this field both in theory and in experiment, which have brought better and new understandings on the clustering aspects in stable and unstable nuclei. I think, the concept of clustering has been more important than ever. This is true also in the

  18. [Health examination in future at the era of low tuberculosis incidence--from contacts examination toward active epidemiological studies].

    PubMed

    Maeda, Hideo; Shirai, Chika

    2013-03-01

    test in Tokyo: Hideo MAEDA (Bureau of Social Welfare and Public Health, Tokyo Metropolitan Government). 2. Contact investigation of a tuberculosis outbreak: Kenichi MIYAMOTO (Takaido Community Health Center). We have experienced a TB outbreak in integrated junior and senior high school in Tokyo. Index patient was a student with persistent respiratory symptoms for six months before diagnosis of sputum smear-positive TB. Public health center started contact investigation immediately. QFT-positive rates were high in close contacts, especially in classmates. Additionally, a student outside of contact investigation was diagnosed as TB and considered to be infected from the first patient by VNTR analysis. Therefore, public health center expanded QFT-tests to all students and teachers in this school. Finally, 9 students and 2 teachers in this school were diagnosed as sputum smear-negative TB by contact investigation. 3. Utilization of molecular epidemiological procedure in contact investigation in Kyoto City: Masahiro ITO (Public Health Center of Kyoto City) Molecular epidemiological procedure using VNTR analysis has been used for contact investigation of tuberculosis since January 2011 in Kyoto City. One hundred forty four strains of Mycobacterium tuberculosis from patients with tuberculosis were investigated and 130 strains were fully analyzed. Fourteen clusters were found and the number of strains included in the cluster was ranged from two to 11. Epidemiological relationship between patients in one cluster was found, however, significant relationship in another clusters was not demonstrated. It was suggested that VNTR analysis is useful for molecular epidemiological analysis of tuberculosis. 4. The population based molecular epidemiological studies and QFT test in a contact examination: Riyo FUJIYAMA, Keisuke MATSUBAYASHI, Setsuko MIZUSHIRI, Junko HIGUCHIL Chika SHIRAI, Yuko KATAGAMI, Mieko CHIHARA, Akihiro IJICHI (Kobe City Public Health Center), Kentaro ARIKAWA, Noriko

  19. Post-fire changes in sediment transport connectivity from pedon to watershed scale. The Navalón wildfire in Eastern Spain

    NASA Astrophysics Data System (ADS)

    Cerdà, Artemi; Bodí, Merche B.; González, Óscar; Mataix Solera, Jorge; Doerr, Stefan Helmut

    2015-04-01

    ., Sheridan, G. J., Smith, H. G., Lane, P. N. J. (2012). Surface runoff and erosion after prescribed burning and the effect of different fire regimes in forests and shrublands: a review. International Journal of Wildland Fire, 21(7), 857-872. Cerdà, A., Lasanta, A. 2005. Long-term erosional responses after fire in the Central Spanish Pyrenees: 1. Water and sediment yield. Catena, 60, 59-80. Doerr, S., Cerdà, A. 2005. Fire effects on soil system functioning: new insights and future challenges International Journal of Wildland Fire Preface. International Journal of Wildland Fire 14(4) 339-342 Guénon, R., Vennetier, M., Dupuy, N., Roussos, S., Pailler, A., Gros, R. 2013. Trends in recovery of Mediterranean soil chemical properties and microbial activities after infrequent and frequent wildfires. Land Degradation & Development, 24: 115- 128. DOI 10.1002/ldr.1109 Kaiho, K., Yatsu, S., Oba, M., Gorjan, P., Casier, J. G., Ikeda, M. (2013). A forest fire and soil erosion event during the Late Devonian mass extinction. Palaeogeography, Palaeoclimatology, Palaeoecology, 392, 272-280. Lasanta, A., Cerdà, A. 2005. Long-term erosional responses after fire in the Central Spanish Pyrenees: 2. Solute release. Catena, 60, 80-101. Pérez-Cabello, F., Cerdà, A., de la Riva, J., Echeverría, M.T., García-Martín, A., Ibarra, P., Lasanta, T., Montorio, R., Palacios, V. 2012. Micro-scale post-fire surface cover changes monitored using high spatial resolution photography in a semiarid environment: A useful tool in the study of post-fire soil erosion processes, Journal of Arid Environments, 76: 88-96. 10.1016/j.jaridenv.2011.08.007 Prats, S.A., Malvar, M.C., Simões-Vieira, D.C., MacDonald, L., Keizer, J.J. 2015. Effectiveness of hydro- mulching to reduce runoff and erosion in a recently burnt pine plantation in central Portugal. Land Degradation & Development, DOI: 10.1002/ldr.2236.

  20. EDITORIAL: Focus on Iron-Based Superconductors FOCUS ON IRON-BASED SUPERCONDUCTORS

    NASA Astrophysics Data System (ADS)

    Hosono, Hideo; Ren, Zhi-An

    2009-02-01

    Elastic theory for the vortex-lattice melting in iron-based high-Tc superconductors Q-H Chen, Q-M Nie, J-P Lv and T-C Au Yeung Electronic properties of LaO1-xFxFeAs in the normal state probed by NMR/NQR H-J Grafe, G Lang, F Hammerath, D Paar, K Manthey, K Koch, H Rosner, N J Curro, G Behr, J Werner, N Leps, R Klingeler, H-H Klauss, F J Litterst and B Büchner AFe2As2 (A = Ca, Sr, Ba, Eu) and SrFe2-xTMxAs2 (TM = Mn, Co, Ni): crystal structure, charge doping, magnetism and superconductivity Deepa Kasinathan, Alim Ormeci, Katrin Koch, Ulrich Burkhardt, Walter Schnelle, Andreas Leithe-Jasper and Helge Rosner Impurity states in a family of antiferromagnetic iron arsenides Qiang Han and Z D Wang Coherence-incoherence crossover in the normal state of iron oxypnictides and importance of Hund's rule coupling K Haule and G Kotliar Electronic structure of heavily electron-doped BaFe1.7Co0.3As2 studied by angle-resolved photoemission Y Sekiba, T Sato, K Nakayama, K Terashima, P Richard, J H Bowen, H Ding, Y-M Xu, L J Li, G H Cao, Z-A Xu and T Takahashi Absorption and photoemission spectroscopy of rare-earth oxypnictides T Kroll, F Roth, A Koitzsch, R Kraus, D R Batchelor, J Werner, G Behr, B Büchner and M Knupfer Superconductivity in LnFePO (Ln = La, Pr and Nd) single crystals R E Baumbach, J J Hamlin, L Shu, D A Zocco, N M Crisosto and M B Maple Unconventional pairing originating from disconnected Fermi surfaces in the iron-based superconductor Kazuhiko Kuroki, Seiichiro Onari, Ryotaro Arita, Hidetomo Usui, Yukio Tanaka, Hiroshi Kontani and Hideo Aoki Near-degeneracy of several pairing channels in multiorbital models for the Fe pnictides S Graser, T A Maier, P J Hirschfeld and D J Scalapino Investigation of superconducting gap structure in TbFeAsO0.9F0.1 using point contact Andreev reflection K A Yates, K Morrison, J A Rodgers, G B S Penny, J-W G Bos, J P Attfield and L F Cohen Competition of magnetism and superconductivity in underdoped (Ba1-xKx)Fe2As2 Marianne Rotter, Marcus

  1. PREFACE: Tenth International Conference on Topics in Astroparticle and Underground Physics (TAUP2007)

    NASA Astrophysics Data System (ADS)

    Inoue, Kunio; Suzuki, Atsuto; Mitsui, Tadao

    2008-07-01

    The tenth meeting of the TAUP Workshop Series, TAUP 2007, was organized by the Research Center for Neutrino Science, Tohoku University. In TAUP 2007 all the various aspects of Astroparticle Physics have been covered, from Cosmology and Dark Constituents, to Gravitational Waves, to Neutrino Physics and Astrophysics, to High Energy Astrophysics, to Cosmic Rays and Gamma-Rays Astronomy. New and important scientific results were presented and debated in the plenary review talks and in a very large number of contributions in topical parallel sessions. As editors of these proceedings, we hope that this volume, which contains most of the talks and contributions presented at TAUP 2007, will provide a detailed state-of-the-art account of the various facets of Astroparticle Physics. We thank all the invited speakers, conveners, and contributors who made this possible. Full coverage of the transparencies presented at the conference can be found on the website http://www.awa.tohoku.ac.jp/taup2007. The TAUP 2007 Organizing Committee thanks IUPAP/PaNAGIC, Sendai Tourism and Convention Bureau, COE program: Exploring New Science by Bridging Particle-Matter Hierarchy, SEIKO EG&G, and REPIC corporation for sponsoring the Conference, and Sendai Civic Auditorium, where the meeting was held, for their hospitality. We wish to thank Alessandro Bottino, Junpei Shirai, Fumihiko Suekane, David Sinclair, Takaaki Kajita, Takeo Moroi, Masaki Mori, Masahiro Kawasaki, Yoshihito Gando, Sei Yoshida, Kyoko Tamae, Sanshiro Enomoto, Alexandre Kozlov, Yasuhiro Kishimoto, Itaru Shimizu, Kengo Nakamura, Haruo Ikeda, and Kyo Nakajima for their invaluable contribution in the scientific shaping of the conference and in the preparation of the present volume. The Organizing Committee is grateful to the members of the International Advisory Committee and of the TAUP Steering Committee for assistance and advice on the scientific program. Very special thanks are due to Ms Rika Bizen, Mr Fujio Miura, Ms Akemi

  2. PREFACE: Domain wall dynamics in nanostructures Domain wall dynamics in nanostructures

    NASA Astrophysics Data System (ADS)

    Marrows, C. H.; Meier, G.

    2012-01-01

    spin-transfer torque threshold current density in coupled vortex domain wallsS Lepadatu, A P Mihai, J S Claydon, F Maccherozzi, S S Dhesi, C J Kinane, S Langridge and C H Marrows Large RF susceptibility of transverse domain wallsO Rousseau, S Petit-Watelot and M Viret Expansion and relaxation of magnetic mirror domains in a Pt/Co/Pt/Co/Pt multilayer with antiferromagnetic interlayer couplingP J Metaxas, R L Stamps, J-P Jamet, J Ferré, V Baltz and B Rodmacq Current-induced domain wall motion and magnetization dynamics in CoFeB/Cu/Co nanostripesV Uhlíř, J Vogel, N Rougemaille, O Fruchart, Z Ishaque, V Cros, J Camarero, J C Cezar, F Sirotti and S Pizzini Roles of the magnetic field and electric current in thermally activated domain wall motion in a submicrometer magnetic strip with perpendicular magnetic anisotropySatoru Emori and Geoffrey S D Beach Electrical domain morphologies in compositionally graded ferroelectric filmsM B Okatan, A L Roytburd, V Nagarajan and S P Alpay Domain-wall pinning by local control of anisotropy in Pt/Co/Pt strips J H Franken, M Hoeijmakers, R Lavrijsen and H J M Swagten Experimental detection of domain wall propagation above the Walker field Kouta Kondou, Norikazu Ohshima, Daichi Chiba, Shinya Kasai, Kensuke Kobayashi and Teruo Ono Enhanced functionality in magnonics by domain walls and inhomogeneous spin configurationsG Duerr, R Huber and D Grundler Domain wall motion in perpendicular anisotropy nanowires with edge roughness Maximilian Albert, Matteo Franchin, Thomas Fischbacher, Guido Meier and Hans Fangohr Determination of the spin torque non-adiabaticity in perpendicularly magnetized nanowiresJ Heinen, D Hinzke, O Boulle, G Malinowski, H J M Swagten, B Koopmans, C Ulysse, G Faini, B Ocker, J Wrona and M Kläui Domain wall dynamics driven by spin transfer torque and the spin-orbit field Masamitsu Hayashi, Yoshinobu Nakatani, Shunsuke Fukami, Michihiko Yamanouchi, Seiji Mitani and Hideo Ohno Dynamic propagation and nucleation in domain

  3. PREFACE: The Sixth International Conference on Gravitation & Cosmology

    NASA Astrophysics Data System (ADS)

    Date, Ghanashyam; Souradeep, Tarun

    2008-07-01

    (Chennai), RRI (Bangalore), SINP (Kolkata) and IUCAA. The conference banquet was sponsored by Hewlett-Packard and the reception dinner was sponsored by the Bank of Baroda. We thank them all. It is a pleasure to thank Professor Naresh Dadhich, Director, IUCAA, members of the IAGRG council, members of the SOC and members of the LOC for their pivotal role in the organization of the conference, and the speakers, the participants, and the IUCAA staff for their efforts which made the sixth ICGC a very successful meeting. Ghanashyam Date Institute for Mathematical Science, Chennai Tarun Souradeep Inter-University Centre for Astronomy & Astrophysics, Pune Scientific Organizing Committee Ghanashyam Date (Chairman, SOC, IMSc, India) Abhay Ashtekar (Pennsylvania State Univ., US) Bhuvnesh Jain (Univ. of Pennsylvania, US) Carlo Rovelli (CPT, Marseille, France) Clifford M. Will (Washington Univ., US) Gabriela Gonza'lez (Lousiana State Univ., US) Hideo Kodama (Kyoto Univ. Japan) John Ellis (CERN, Switzerland) Luc Blanchet (IAP, France) Madhavan Varadarajan (RRI, India) Masaru Shibata (Univ. of Tokyo, Japan) Narayan Banerjee (Jadavpur Univ. India) Parthasarathi Mitra (SINP, India) Rajesh Gopakumar (HRI, India) Sanjeev Dhurandhar (IUCAA, India) Somnath Bharadwaj (IITKGP, India) Subhendra Mohanty (PRL, India) Subir Sarkar (Univ. of Oxford, UK) Tarun Souradeep (IUCAA, India) T. P. Singh (TIFR, India) Local Organizing Committee Tarun Souradeep (Chairman, LOC) Biswajit Pandey Gaurang Mahajan Manjiri Mahabal Maulik Parikh Minu Joy Moumita Aich Niranjan Abhyankar Nirupama Bawdekar Ratna Rao Saugata Chatterjee Savita Dalvi Sharanya Sur Snehlata Shankar Subharthi Ray Sudhanshu Barway Tuhin Ghosh Plenary Speakers and Talks The Plenary Talks are available at http://meghnad.iucaa.ernet.in/~icgc07/ Gary Hinshaw Status of WMAP Data Andrew Jaffe The Future of CMB Studies Subir Sarkar Cosmology beyond the Standard Model HongSheng Zhao Dark Matter and Dark Energy: Puzzles and an Alternative Solution

  4. [Studies on the intradermal reactions with the fractions of Ascaris lumbricoides

    PubMed

    Lee, Chan Wook

    1967-06-01

    INTRODUCTION : The studies on allergic reaction with the substances of Ascaris lumbricoides have long been studied by various worers; Conventry(1929), Campbell(1936), Sakei(1949), Miyakawa(1950), Ikeda(1952), Matsumoto and Imawari(1952), Morishita and Kobayashi(1953, 1954), Komiyayama(1954) and Yammoto(1956). Campbell(1936) and some other workers reported that the polysaccharides from ascaris produced the stronger intrademal reactions than protein fraction, though Yamamoto(1954) and others found the reverse results. On the other hand, Hosotani(1954) reported that the crude antigen or mixed antigen with polysaccharide and protein fraction of the ascaris produced the strongest skin reaction than with the other single fraction. As are shown in above reports, the intensity of the allergic reaction with the substances from ascaris is still remained under dipute. The reason might be due to the difference of the method of preparation, technique and evaluation. The aim of the present study is to elucidate the intensity of allergic reactivity fo protein and polysaccharide fration and mixed substance of two fractions and crude antigen of Ascaris lumbricoides. MATERIALS AND METHODS : A Intrdermal Test 1. Human Experiment. The intradermal test was performed on several groups of people. A: Ascaris lumbricoides egg positive cases among adult ages. B: Ascaris lumbricoides egg negative cases but who bad doubtful symptom. C: Ascaris lumbricoides egg negative cases but who had past history of ascaris infection. D: Ascaris lumbricoides egg negative cases and aged 3-8 months old. 2. Animal Experiment: Same breeds of 6 dogs were raised i cages of laboratory for 6 months, During the period, special attention was paid to keep them in parasite free conditon. The body weight was 10kg in average. B. Antigens. The adults worms of Ascaris lumbricoides, which were obtained during laparotomy, were first washed with sterilized saline solution. Each ascaris was placed in 50ml of saline solution

  5. Physics of Unstable Nuclei

    NASA Astrophysics Data System (ADS)

    Khoa, Dao Tien; Egelhof, Peter; Gales, Sydney; Giai, Nguyen Van; Motobayashi, Tohru

    2008-04-01

    ]C([symbol], n)[symbol]O by the transfer reaction [symbol]C([symbol]Li, t)[symbol]O / F. Hammache et al. -- SPIRAL2 at GANIL: a world of leading ISOL facility for the physics of exotic nuclei / S. Gales -- Magnetic properties of light neutron-rich nuclei and shell evolution / T. Suzuki, T. Otsuka -- Multiple scattering effects in elastic and quasi free proton scattering from halo nuclei / R. Crespo et al. -- The dipole response of neutron halos and skins / T. Aumann -- Giant and pygmy resonances within axially-symmetric-deformed QRPA with the Gogny force / S. Péru, H. Goutte -- Soft K[symbol] = O+ modes unique to deformed neutron-rich unstable nuclei / K. Yoshida et al. -- Synthesis, decay properties, and identification of superheavy nuclei produced in [symbol]Ca-induced reactions / Yu. Ts. Oganessian et al. -- Highlights of the Brazilian RIB facility and its first results and hindrance of fusion cross section induced by [symbol]He / P. R. S. Gomes et al. -- Search for long fission times of super-heavy elements with Z = 114 / M. Morjean et al. -- Microscopic dynamics of shape coexistence phenomena around [symbol]Se and [symbol]Kr / N. Hinohara et al. -- [symbol]-cluster states and 4[symbol]-particle condensation in [symbol]O / Y. Funaki et al. -- Evolution of the N = 28 shell closure far from stability / O. Sorlin et al. -- Continuum QRPA approach and the surface di-neutron modes in nuclei near the neutron drip-line / M. Matsuo et al. -- Deformed relativistic Hartree-Bogoliubov model for exotic nuclei / S. G. Zhou et al. -- Two- and three-body correlations in three-body resonances and continuum states / K. Katō, K. Ikeda -- Pion- and Rho-Meson effects in relativistic Hartree-Fock and RPA / N. V. Giai et al. -- Study of the structure of neutron rich nuclei by using [symbol]-delayed neutron and gamma emission method / Y. Ye et al. -- Production of secondary radioactive [symbol] Na beam for the study of [symbol]Na([symbol], p)[symbol]Mg stellar reaction / D. N. Binh et al

  6. EDITORIAL: Cluster issue on Heusler compounds and devices Cluster issue on Heusler compounds and devices

    NASA Astrophysics Data System (ADS)

    Felser, Claudia; Hillebrands, Burkard

    2009-04-01

    ] Sakuraba Y, Hattori M, Oogane M, Ando Y, Kato H, Sakuma A, Miyazaki T and Kubota H 2006 Appl. Phys. Lett. 88 192508 [11] Inomata K, Okamura S, Miyazaki A, Kikuchi M, Tezuka N, Wojcik M and Jedryka E 2006 J. Phys. D: Appl. Phys. 39 816 [12] Fecher G H and Felser C 2007 J. Phys. D: Appl. Phys. 40 1582 [13] Tezuka N, Ikeda N, Miyazaki A, Sugimoto S, Kikuchi M and Inomata K 2006 Appl. Phys. Lett. 89 112514 [14] Kallmayer M, Schneider H, Jakob G, Elmers H J, Balke B and Cramm S 2007 J. Phys. D: Appl. Phys. 40 1552 [15] Cinchetti M, Wüstenberg J P, Sánchez Albaneda M, Steeb F, Conca A, Jourdan M and Aeschlimann M 2007 J. Phys. D: Appl. Phys. 40 1544 [16] Fecher G H, Balke B, Ouardi S, Felser C, Schonhense G, Ikenaga E, Kim J J, Ueda S and Kobayashi K 2007 J. Phys. D: Appl. Phys. 40 1576 [17] Chioncel L, Sakuraba Y, Arrigoni E, Katsnelson M I, Oogane M, Ando Y, Miyazaki T, Burzo E and Lichtenstein A I 2008 Phys. Rev. Lett. 100 086402 [18] Hamrle J, Blomeier S, Gaier O, Hillebrands B, Schneider H, Jakob G, Postava K and Felser C 2007 J. Phys. D: Appl. Phys. 40 1563 [19] Furubayashi T, Kodama K, Sukegawa H, Takahashi Y K, Inomata K and Hono K 2008 Appl. Phys. Lett. 93 122507 [20] Balke B, Fecher G H, Winterlik J and Felser C 2007 Appl. Phys. Lett. 90 152504 [21] Wurmehl S, Kandpal H C, Fecher G H and Felser C 2006 J. Phys.: Cond. Mat. 18 6171 [22] Entel P, Bucheinikov V D, Khovailo V V, Zayak A T, Adeagbo W A, Gruner M E, Herper H C and Wassermann E F 2006 J. Phys. D: Appl. Phys. 39 865