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Sample records for apres chirurgie bariatrique

  1. Cinétique de la troponine Ic et valeurs seuils pour le diagnostic d'infarctus du myocarde après chirurgie cardiaque sous circulation extracorporelle

    PubMed Central

    Kallel, Samy; Jarraya, Anwar; Ellouze, Maged; Frikha, Imed; Karoui, Abbdelhamid

    2012-01-01

    Introduction L'objectif de ce travail était d’étudier la cinétique de la Troponine Ic (TnIc) après chirurgie cardiaque sous circulation extracorporelle (CEC) et établir des valeurs seuils de TnIc pour le diagnostic d'infarctus du myocarde (IDM) post opératoire. Il s'agissait d'une étude prospective type cohorte observationnelle. Méthodes Nous avons inclus 37 patients âgés de plus de 18 ans proposés pour chirurgie valvulaire ou pontage aorto coronarien sous CEC. Nous avons suivi la cinétique de TnIc par des dosages immunoenzymatique sur mini-vidas® avant et après la CEC, à H4 et H12 postopératoire puis tous les jours les 4 premiers jours. Le cutoff pour le diagnostic d'IDM post opératoire a été défini comme la valeur moyenne de troponine + deux déviations standards des patients indemnes de complications cardiaques. Résultats Les valeurs de TnIc en préopératoire étaient toutes inférieures au seuil de détection de la méthode de dosage (<0,01µg/l). Les valeurs de TnIc augmentent en postopératoire immédiat pour atteindre un maximum à H4 puis diminuent progressivement pour se normaliser après 4 à 5 jours. Les valeurs seuils ont été déterminées pour H0, H4,H12, H24, H48, H72, H96 et ont été respectivement 1.36, 2.58, 3.1, 3.23, 2.13, 1.53, 1.17 pour la chirurgie coronaire et 3.75, 5.39, 4.22, 3.41, 1.65, 1.3 1.19 pour la chirurgie valvulaire. Conclusion La connaissance de la cinétique de TnIc lors de chirurgie cardiaque non compliquée et la fixation de valeur seuil ou Cutoff permet aux cliniciens de distinguer entre dommage myocardique secondaire à la chirurgie et IDM. PMID:23396754

  2. Le syndrome de sevrage nicotinique après chirurgie cardiaque: à propos d’un cas

    PubMed Central

    Kallel, Samy; Ellouze, Maged; Triki, Zied; Karoui, Abdelhamid

    2012-01-01

    L’agitation post-opératoire constitue une pathologie extrêmement fréquente. Les étiologies à évoquer en réanimation sont nombreuses. Le syndrome de sevrage à la nicotine est une cause possible mais rarement évoquée. Nous rapportons le cas d’un patient tabagique qui a été admis en unité de soins intensifs pour un triple pontage aorto-coronaire sous circulation extracorporelle. Les suites opératoires ont été marquées par des difficultés de sédation du patient et puis la survenue d’une agitation au réveil et d’un échec du sevrage de la ventilation mécanique. Après avoir éliminer toutes les causes organiques d’agitation, le syndrome de sevrage à la nicotine a été évoqué et la mise en place d’un timbre de nicotine a permis une amélioration rapide de l’agitation et le sevrage de la ventilation mécanique. Cette observation suggère que le syndrome de sevrage nicotinique peut être responsable d’un véritable delirium et la mise en place d’un timbre transdermique à la nicotine pourrait constituer un moyen diagnostique et thérapeutique simple. PMID:23308317

  3. Epidémiologie et facteurs de risque des complications respiratoires majeures après chirurgie de l'aorte abdominale au CHU Ibn Sina, Maroc

    PubMed Central

    Awab, Almahdi; Elahmadi, Brahim; Lamkinsi, Tarik; El Moussaoui, Rachid; El Hijri, Ahmed; Azzouzi, Abderrahim; Alilou, Mustapha

    2013-01-01

    Introduction L'incidence des complications respiratoires postopératoires (CRPO) reste très diversement appréciées selon les critères diagnostiques retenues dans les différentes études, ce qui la fait varier de 5 à plus de 50%. Les CRPO majeurs après chirurgie de l'aorte abdominale sont responsables d'une grande morbi-mortalité pouvant aller jusqu’à 36%, d'une durée d'hospitalisation et d'un coût plus importants. Ainsi dans l'optique d'améliorer notre prise en charge périopératoire de la chirurgie de l'aorte, nous avons décidé de mener une étude pour dresser le profil épidémiologique et déterminer les facteurs de risque des complications respiratoires dans notre contexte Méthodes Il s'agit d'une étude de cohorte rétrospective du mois de Janvier 2007 au mois de décembre 2011 portant sur l'ensemble des patients opérés pour pathologie aortique au bloc opératoire central de l'hôpital Ibn Sina de Rabat, Maroc. Résultats Cent vingt cinq patients ont été inclus dans notre étude, 24 patients ont été opérés pour anévrysme de l'aorte abdominale et 101 patients pour lésion occlusive aortoiliaque. Dans notre série 22 malades soit 17,6% ont présenté une complication respiratoire majeure avec, une reventilation dans 4,8% des cas, une difficulté de sevrage de la ventilation artificielle dans 3,2% des cas, une pneumopathie dans 4% des cas, un syndrome de détresse respiratoire aigue (SDRA) dans 4% des cas et une nécessité de fibroaspiration bronchique dans 1,6% des cas. En analyse univariée: l’âge, la présence d'une BPCO avec dyspnée stade 3 ou 4, la présence d'une anomalie à l'EFR préopératoire, la présence d'un stade avancé (III ou IV) de LOAI et la reprise chirurgicale étaient statistiquement associés à la survenue d'une complication respiratoire postopératoire. En analyse multivariée, seule une anomalie à l'EFR en préopératoire constituait un facteur de risque indépendant de survenue d'une complication

  4. Pronostic visuel et évolution réfractive après chirurgie de la cataracte congénitale avec implantation primaire: étude d'une série de 108 cas

    PubMed Central

    Hafidi, Zouheir; Ibrahimy, Wafaa; Ahid, Samir; Handor, Hanan; Ouafae Cherkaoui, Lalla; Bencherif, Zahid; Laghmari, Mina; Ouazzanni, Btissam; Boutimzine, Noureddine; Daoudi, Rajae

    2013-01-01

    La cataracte congénitale constitue la cause la plus fréquente de cécité évitable chez les enfants. Le but de cette étude est d’évaluer le pronostic réfractif et fonctionnel, des enfants opérés de cataracte congénitale avec implantation. Il s'agit d'une étude rétrospective de 108 enfants, dont 85 cataractes bilatérales, 23 unilatérales opérés entre 2007 et 2011. La réfraction a été mesurée à 1 mois, 3 mois, 6 mois, 1 an, 2 ans, 3 ans et/ou 4 ans en post-opératoire. La meilleure acuité visuelle corrigée, ainsi que l'incidence des complications post-opératoires ont été analysé. L’âge moyen de la chirurgie était de 25 mois avec une durée moyenne de suivi de 3,17 ans. Les complications retrouvées étaient l'inflammation, la prolifération secondaire, et le glaucome. L'acuité visuelle (AV) moyenne corrigée finale était de 5,75/10e pour les formes bilatérales, et de 4,16/10e pour les unilatérales (p = 0,001). Les facteurs de mauvais pronostic retrouvés étaient l’âge tardif de la chirurgie, la densité de la cataracte et la survenue de complications (p = 0,001). L'incidence des complications post-opératoires était significativement plus élevé chez les enfants opérés à un jeune âge (p = 0,001). Les facteurs de mauvais pronostic visuel chez les enfants opérés pour cataracte congénitale avec implantation, sont représentés par le caractère unilatéral de la cataracte, l’âge tardif de la chirurgie, la densité de la cataracte et la survenue de complications post opératoires. PMID:24672622

  5. La chirurgie du diaphragme sous aortique

    PubMed Central

    Moutakiallah, Younes; Maaroufi, Ilham; Aithoussa, Mahdi; Bamous, Mehdi; Abdou, Abdessamad; Atmani, Noureddine; Hatim, Abdedaïm; Amahzoune, Brahim; Bekkali, Youssef El; Boulahya, Abdelatif

    2016-01-01

    Le diaphragme sous aortique se caractérise par une certaine latence clinique et une faible morbi-mortalité. La chirurgie reste le traitement de choix malgré un réel risque de récurrence à long terme. Nous rapportons 18 patients opérés entre Avril 1994 et Mars 2011 pour diaphragme sous aortique d’âge moyen de 18,1±9,7 ans avec 11 patients de sexe masculin. Le diaphragme était de nature fibreuse chez 13 patients et fibro-musculaire chez 5 patients. Tous les patients ont été opérés par résection de diaphragme associée à une myectomie, une plastie aortique, une fermeture de communication interventriculaire et une ligature de canal artériel perméable respectivement chez 3, 3, 2 et 2 patients. La Mortalité opératoire était nulle et sans aucun cas de trouble de conduction postopératoire. Le suivi a duré en moyenne 44,3±36,8 mois sans aucun décès tardif. Deux patients ont présenté une récidive de diaphragme qui a nécessité une réopération avec bonne évolution. La tendance actuelle dans la chirurgie du diaphragme se fait vers des interventions précoces et des résections plus extensives. Cependant, le risque de récidive impose une surveillance échographique systématique et rapprochée. PMID:27516830

  6. The scientific contributions of British Plastic Surgeons to the Revue de Chirurgie Plastique and the Revue de Chirurgie Structive, Brussels (1931-1938).

    PubMed

    Vrebos, J

    2001-01-01

    In 1931, Maurice Coelst, M.D. from Brussels started the publication of the first international journal of plastic surgery ever published: the Revue de Chirurgie Plastique (1931-1934), which eventually became the Revue de Chirurgie Structive (1935-1938). In 1936, he established the first European Society of Structive Surgery, which held its first congress in Brussels. Further congresses were held in London in 1937 and in Milan in 1938. It is the collaboration and the participation of British plastic surgeons in this Society, this journal, and these meetings that I want to stress, because I am firmly convinced that these documents fill a gap in the history of Plastic Surgery in Great Britain, since--as far as I know--no detailed information concerning this period was ever published in Plastic Surgery literature. PMID:11426315

  7. APR-2 Tropical Cyclone Observations

    NASA Technical Reports Server (NTRS)

    Durden, S. L.; Tanelli, S.

    2011-01-01

    The Second Generation Airborne Precipitation Radar (APR-2) participated in the Genesis and Rapid Intensification Processes (GRIP) experiment in August and September of 2010, collecting a large volume of data in several tropical systems, including Hurricanes Earl and Karl. Additional measurements of tropical cyclone have been made by APR-2 in experiments prior to GRIP (namely, CAMEX-4, NAMMA, TC4); Table 1 lists all the APR-2 tropical cyclone observations. The APR-2 observations consist of the vertical structure of rain reflectivity at 13.4 and 35.6 GHz, and at both co-polarization and crosspolarization, as well as vertical Doppler measurements and crosswind measurements. APR-2 normally flies on the NASA DC-8 aircraft, as in GRIP, collecting data with a downward looking, cross-track scanning geometry. The scan limits are 25 degrees on either side of the aircraft, resulting in a roughly 10-km swath, depending on the aircraft altitude. Details of the APR-2 observation geometry and performance can be found in Sadowy et al. (2003).The multiparameter nature of the APR-2 measurements makes the collection of tropical cyclone measurements valuable for detailed studies of the processes, microphysics and dynamics of tropical cyclones, as well as weaker systems that are associated with tropical cyclone formation. In this paper, we give a brief overview of how the APR-2 data are processed. We also discuss use of the APR-2 cross-track winds to estimate various quantities of interest in in studies of storm intensification. Finally, we show examples of the standard products and derived information.

  8. Résultats de la chirurgie avancée de la cataracte par tunnélisation: à propos de 262 cas réalisés au CHR de Banfora (Burkina Faso)

    PubMed Central

    Djiguimdé, Pierre Windinmanégdé; Diomandé, Ibrahim Abib; Ahnoux-Zabsonré, Ahgbatouhabéba; Koffi, Konan Virgile; Meda, Tierinyê Armand; Diomandé, Gossé François; Sanou, Jerôme; Meda-Hien, Gertude; Sankara, Paté; Meda, Nonfounikoun

    2015-01-01

    La cataracte demeure la première cause de cécité dans les pays en voie de développement posant un problème de santé publique. Le but de cette étude est de faire le bilan d'une activité de chirurgie avancée de la cataracte par la technique dite de « phacoalternative » ou par tunnélisation. Il s'agissait d'une étude prospective de base réalisée au Burkina Faso portant sur la chirurgie de la cataracte par la technique de tunnélisation. L’âge moyen de nos patients atteints de cataracte était de 62,47 ± 12,77 ans avec un sex-ratio de 0,98. La majorité des patients opérés (82,82%) étaient des cultivateurs et des ménagères. L'acuité visuelle de loin était réduite à la perception lumineuse dans 68,70% des cas. La profondeur moyenne de la chambre antérieure était de 2,98 ± 0,53 mm. L’épaisseur moyenne du cristallin était de 3,55 ± 0,75 mm. La longueur axiale moyenne de l’œil de nos patients opérés de la cataracte était de 22,88 ± 0,90 mm. La puissance réfractive moyenne estimée de la cornée était de 43,21 ± 2,03 dioptries chez nos patients. La puissance moyenne estimée de l'implant intra oculaire (IOL) utilisé était de23,11 ± 2,35D. La majorité (79,6%) de nos patients avait une bonne acuité visuelle après la chirurgie de la cataracte par tunnélisation. La chirurgie de la cataracte par tunnélisation est une technique révolutionnaire adaptée aux pays pauvres d'Afrique. Elle permet une lutte efficace à moindre coût contre la cécité par cataracte dans nos régions. La tunnélisation est une technique chirurgicale adaptée pour lutter efficacement contre la cécité due à la cataracte en Afrique. PMID:27022426

  9. Arrêt cardiaque au cours d'une chirurgie de kyste hydatique du foie

    PubMed Central

    Ouzzad, Omar; Kechna, Hicham; Moudden, Mohamed Karim; Chkoura, Khalid; Hanafi, Sidi Mohamed

    2015-01-01

    L'hydatidose est une pathologie fréquente qui reste encore endémique au Maroc. Sa localisation privilégiée est le foie. Son traitement repose essentiellement sur la chirurgie. Celui-ci est parfois incriminé dans la survenue de réactions allergiques sévères pouvant menacer le pronostic vital. Nous rapportons un nouveau cas de réaction anaphylactique sévère de grade IV peropératoire au cours d'une chirurgie de kystes hydatiques multiples du foie. Nous insistons sur la nécessité de sa reconnaissance rapide afin d'instaurer rapidement un traitement efficace. La prévention de cet accident est basée sur des précautions chirurgicales pour éviter les fuites ou les ruptures accidentelles peropératoires des kystes hydatiques. PMID:26664533

  10. La chirurgie coronaire sous circulation extra-corporelle chez le patient diabétique

    PubMed Central

    Moutakiallah, Younes; Benzaghmout, Khadija; Aithoussa, Mahdi; Atmani, Nourreddine; Amahzoune, Brahim; Hatim, Abdedaim; Drissi, Mohamed; Benyass, Aatif; ElBekkali, Youssef; Boulahya, Abdelatif

    2014-01-01

    Nous rapportons les résultats de la chirurgie coronaire chez une population de coronariens diabétiques opérés sous circulation extra-corporelle dans le service de chirurgie cardiaque de l'hôpital militaire d'instruction Mohammed V de Rabat. C'est une étude rétrospective menée entre Janvier 2008 et Février 2012 (4 ans), portant sur 103 patients diabétiques consécutifs opérés pour pontage coronaire. L’âge moyen des patients était de 61±8,7ans (37-82ans) avec un sexe ratio (H/F) de 3,9. Tous les patients diabétiques de type 2 et sous traitement anti-diabétique ont été inclus dans cette étude. La sténose du tronc commun gauche était présente chez 26,2% des patients et 53,4% étaient tritronculaires. Quatre-vingt patients (78,6%) étaient insulino-nécessitant, l'Euro-score moyen était de 1,63±1% et le nombre moyen de pontage de 2,3±0,7. Les durées moyennes de la circulation extra-corporelle et du clampage aortique étaient respectivement de 134,4 ± 42 min et 76 ± 28 min. La mortalité hospitalière était de 2 décès (1,9%), les durées moyennes de ventilation artificielle, du séjour en réanimation et du séjour postopératoire étaient respectivement de 7h (5-16h), 48h (42-52h) et 15,6 ± 8,6 jours. Les complications postopératoires étaient l'infarctus du myocarde, l'infection de paroi, la médiastinite et le bas débit cardiaque chez respectivement 1,9%, 10,7%, 3,9% et 1,9% des patients. Il ressort de notre étude, que les facteurs prédictifs d'infection post opératoire étaient la durée de ventilation artificielle (p = 0,002), la durée de la circulation extra-corporelle (p < 0,001) en plus du tabac (p = 0,004) et de l'obésité (p = 0,005). Les patients ont été contactés par téléphone ou lors de la consultation régulière de contrôle. Le taux de suivi a atteint 92,1% et la survie à 2 ans était de 98,9% des patients contrôlés avec une mortalité tardive de 1% avec un décès suite à un accident vasculaire c

  11. Pratique anesthésique à Lubumbashi: indications, types de chirurgie et types de patient

    PubMed Central

    Kabey, Alain Kabey a; Lubanga, Muyumba; Tshamba, Mundongo; Kaut, Mukeng; Kakambal, Kaij; Muteya, Manika; Manzanza, Kilembe; Kalal, Kapend

    2015-01-01

    Introduction Cette étude a pour objectif de décrire la pratique anesthésique dans un pays à faible revenu et où le plateau technique anesthésique est moins équipé. Méthodes Une étude descriptive transversale a été menée durant l'année 2013. L'enquête a concerné les pratiques anesthésiques, les indications chirurgicales et les caractéristiques des malades. L'encodage et l'analyse des données ont été réalisées grâce aux logiciels Epi Info 3.5.3 et Excel 2010. Résultats Nous avons enregistré 2358 patients dont l’âge médian était de 29 + 15 ans, avec 81,5% âgés de 11 à 50 ans. Parmi eux, 67,3% des malades étaient du sexe féminin. Dans ensemble, 62,5% de ces patients étaient pris en charge pour les interventions programmées. L’évaluation du risque anesthésique a montré que 91,9% des patients étaient de la classe ASA I et II. La chirurgie la plus pratiquée était viscérale (46,7%) suivie de la chirurgie gynéco-obstétricale (29,2%). Les différents types d'anesthésie étaient les suivants: anesthésie générale (87,6%), locorégionale (11,8%) et combinée (0,6%). Conclusion La pratique anesthésique dans la population d’étude était dominée par l'anesthésie générale. Les malades étaient au trois quart de sexe féminin et de la classe ASA I et II. Les résultats de cette étude indiquent la nécessité d’évaluer l'issue de cette pratique. La pratique anesthésique à Lubumbashi est tributaire du plateau technique, des compétences du personnel et de l'acceptabilité du type d'anesthésie par les patients. PMID:26523180

  12. Evaluating SPP/APR Improvement Activities

    ERIC Educational Resources Information Center

    National Early Childhood Technical Assistance Center (NECTAC), 2009

    2009-01-01

    This document is intended to assist State Education Agency (SEA) and Lead Agency (LA) staff and technical assistance providers in designing a meaningful evaluation for the State Performance Plan (SPP)/Annual Performance Report (APR) improvement activities. It provides: (1) information about the relevance of evaluation in the context of improvement…

  13. Characterization of AprE176, a fibrinolytic enzyme from Bacillus subtilis HK176.

    PubMed

    Jeong, Seon-Ju; Heo, Kyeong; Park, Ji Yeong; Lee, Kang Wook; Park, Jae-Yong; Joo, Sang Hoon; Kim, Jeong Hwan

    2015-01-01

    Bacillus subtilis HK176 with high fibrinolytic activity was isolated from cheonggukjang, a Korean fermented soyfood. A gene, aprE176, encoding the major fibrinolytic enzyme was cloned from B. subtilis HK176 and overexpressed in E. coli BL21(DE3) using plasmid pET26b(+). The specific activity of purified AprE176 was 216.8 ± 5.4 plasmin unit/mg protein and the optimum pH and temperature were pH 8.0 and 40°C, respectively. Error-prone PCR was performed for aprE176, and the PCR products were introduced into E. coli BL21(DE3) after ligation with pET26b(+). Mutants showing enhanced fibrinolytic activities were screened first using skim-milk plates and then fibrin plates. Among the mutants, M179 showed the highest activity on a fibrin plate and it had one amino acid substitution (A176T). The specific activity of M179 was 2.2-fold higher than that of the wild-type enzyme, but the catalytic efficiency (kcat/Km) of M179 was not different from the wild-type enzyme owing to reduced substrate affinity. Interestingly, M179 showed increased thermostability. M179 retained 36% of activity after 5 h at 45°C, whereas AprE176 retained only 11%. Molecular modeling analysis suggested that the 176(th) residue of M179, threonine, was located near the cation-binding site compared with the wild type. This probably caused tight binding of M179 with Ca(2+), which increased the thermostability of M179. PMID:25315053

  14. Place de la chirurgie dans la prise en charge des cancers du sein chez la femme au Centre Hospitalier Universitaire Yalgado Ouedraogo: à propos de 81 cas

    PubMed Central

    Zongo, Nayi; Millogo-Traore, Timonga Françoise Danielle; Bagre, Sidpawalmdé Carine; Bagué, Abdoul-Halim; Ouangre, Edgar; Zida, Maurice; Bambara, Aboubacar; Bambara, Tozoula Augustin; Traoré, Si Simon

    2015-01-01

    Etudier la place de la chirurgie dans la prise en charge des cancers du sein au centre hospitalier universitaire Yalgado Ouédraogo. Nous avons réalisé une étude prospective et descriptive sur dix (10) mois portant sur la place de la chirurgie dans le cancer du sein. Elle a eu pour cadre les services de gynécologie-obstétrique et de chirurgie viscérale et digestive du centre hospitalier universitaire Yalgado Ouédraogo. Ont été pris en compte les indications, les gestes et les résultats de la chirurgie. Nous avons colligé 81 cancers mammaires. Le délai moyen de consultation a été de 14,26 mois. Les tumeurs T3 à T4 représentaient 82,71% des cas. Trente-huit patientes (46,91%) ont été opérées. La chimiothérapie néo adjuvante a été réalisée dans 29,63% des cas. Trente-quatre patientes (41,97%) étaient opérables d'emblée. Il s'agissait de mastectomie selon Madden dans 94,74% des cas et de chirurgie de propreté dans 2 cas (5,26% des cas). Une chimiothérapie adjuvante a été réalisée chez 52,63% des patientes opérées. Des complications à type de lymphocèle ont été notées dans 23,68% des cas. Leur traitement a consisté en des ponctions évacuatrices. Les indications de la chirurgie sont limitées par le retard diagnostique corollaire de stades avancés des cancers du sein. L'absence de la radiothérapie rend délicate la pratique de la chirurgie conservatrice et la mastectomie occupe toujours une place importante. Un diagnostic précoce permettrait d'augmenter les indications chirurgicales. PMID:26848364

  15. Les myélopathies cervicarthrosiques: résultat clinique et radiologique de la chirurgie sur une série de 135 patients opérés au service de neurochirurgie CHU Avicenne

    PubMed Central

    Djoubairou, Ben Ousmanou; Nabil, Moussé; Karekezi, Claire; Diawara, Seylan; El Fatemi, Nizar; Gana, Rachid; El Abbadi, Najia; Maaqili, Moulay Rachid

    2014-01-01

    La myélopathie cervicarthrosique est un syndrome clinique en relation avec la diminution des dimensions du canal rachidien, la cervicarthrose est l’étiologie principale après 50 ans. L'objectif du traitement est de rétablir les dimensions du canal rachidien cervical. Le choix de la technique chirurgicale sera guidé par l'analyse des signes cliniques, imageries, pré opératoire en fonction de laquelle sera pratiquée soit la voie antérieure, postérieure, ou exceptionnellement la voie combinée. Notre étude a pour but dans un premier temps d’évaluer à long terme les résultats cliniques et radiologiques de la chirurgie ensuite répondre à cette préoccupation: La lordose cervicale pré opératoire et postopératoire sont t-elles des facteurs de bon pronostic? Nous rapportons une étude rétrospective entre 2000 et 2013 portant sur 135 patients opérés dans notre formation et remplissant les critères inclusions. La collecte des données s'est faite en s'aidant du dossier médical des patients (échelle d'Association des orthopédistes Japonais), Imagerie (Radio, TDM, IRM), mesure de l'angle de courbure rachidienne en pré et postopératoire, ceci dans le but d’évaluer à long terme les résultats clinique et radiologique de la chirurgie. Ont été inclus dans notre étude 135 patients, 82 Hommes (60%), 53 femmes (40%) avec un âge moyen de 52 ans, ayant consulté pour des motifs divers (Névralgies cervicobrachiales, lourdeur des membres, troubles génito-sphinctériens). Soixante cinq patients (48%) ont bénéficié d'un abord antérieur (dissectomie, cloward, somatotomie médiane), 64 patients (47%) ont été opérés par voie postérieure (laminectomie de 1 à 3 niveaux) et 6 patients (5%) ont bénéficié d'un abord combiné dans un délai moyen de 3 mois devant la persistance des symptômes. Le niveau cervical le plus touché était C5C6 suivie de C4C5. L’évolution globale de nos patients était favorable dans 58% des cas, stationnaire

  16. Soins Aux Brules Apres Un Accident Nucleaire

    PubMed Central

    Bargues, L.; Donat, N.; Jault, P.; Leclerc, T.

    2010-01-01

    Summary Les lésions radiques sont dues le plus souvent à des radio-isotopes utilisés dans l’industrie. L’explosion d’un réacteur nucléaire, les armes nucléaires ou une attaque terroriste constituent un risque d’afflux massif de victimes brûlées. Les radiations ionisantes occasionnent des brûlures thermiques, des syndromes d’irradiation aiguë avec pancytopénie et des signes cutanés retardés. Après une période de latence, des symptômes cutanés apparaissent et leur profondeur est proportionnelle à la dose reçue. Les protocoles habituels de réanimation des brûlés s’appliquent ici. Les soins aux irradiés nécessitent aussi une mesure de l’irradiation et une décontamination par des personnels entraînés. En cas de catastrophe nucléaire, la priorité est d’optimiser les structures existantes et de préserver les moyens pour les patients ayant la plus forte probabilité de survie. Après un accident nucléaire isolé, les difficultés dans les centres de brûlés sont l’évaluation de la profondeur et les techniques chirurgicales de couverture cutanée. La préparation des moyens médicaux et des centres de brûlés est nécessaire pour faire face à la prise en charge de ces brûlures différentes et complexes. PMID:21991218

  17. PERSONAL RECOLLECTIONS OF DR. HANS SELYE AND OF HIS INSTITUT DE MèDECINE ET DE CHIRURGIE EXPèRIMENTALES (IMCE).

    PubMed

    Salas-Prato, Milagros

    2014-03-30

    This article is a short personal recollection of Dr. Hans Selye (HS) and of his institute in order to show, first, why and how he influenced us; second, who he was as a person, human being, physician, scientist, professor, mentor; third, what was the structure and functioning of the Institut de Mèdecine et Chirurgie Expèrimentales (IMCE) and fourth, what HS' contributions and accomplishments were. PMID:26118245

  18. Migration pelvienne de broche guide dans la chirurgie des fractures de hanche: à propos de 3 cas

    PubMed Central

    Guèye, Mohamadou Lamine; Thiam, Ousmane; Touré, Alpha Oumar; Seck, Mamadou; Cissé, Mamadou; Kâ, Ousmane; Dieng, Madieng; Dia, Abderahmane; Touré, Cheikh Tidiane

    2015-01-01

    La migration de matériel d'ostéosynthèse est une complication bien connue du traitement chirurgical des fractures. Toutefois, la migration pelvienne de broche guide dans la chirurgie des fractures de la hanche est un incident rare et potentiellement grave. Nous rapportons 3 observations dans lesquelles on notait une migration de broche guide dans le pelvis lors d'une ostéosynthèse dela hanche de type DHS. L'indication chirurgicale était une fracture per-trochantérienne dans 2 cas et une fracture du col fémoral type 4 de Garden dans 1 cas. Une minilaparotomie permettait d'objectiver une plaie du ligament large gauche et un hématome ligamentaire dans 1 cas, tandis que dans les 2 autres cas, il n'y avait pas de lésion viscérale. L'extraction de la broche a été effectuée dans les 3 cas. Les suites opératoires ont été simples chez tous les patients. PMID:26327949

  19. 6. Neg. No. F52, Apr 13, 1930, EXTERIOR EAST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Neg. No. F-52, Apr 13, 1930, EXTERIOR - EAST SIDE OF WAREHOUSE AND LOADING DOCK, SHOWING CRANE, LOOKING NORTH - Ford Motor Company Long Beach Assembly Plant, Crane, 700 Henry Ford Avenue, Long Beach, Los Angeles County, CA

  20. Revision of testing criteria for air cleaning unit of renovated APR-1000 and APR-1400 NPPS.

    PubMed

    Jeong, Seung-Young

    2011-07-01

    Designing Air Cleaning Units (ACU) of an Engineered Safety Feature and normal atmosphere clean-up system at the renovated APR-1000 and APR-1400 NPP, and fuel cycle facilities in Korea, is required to meet the standards of ASME AG-1 (1997), ASME N509/N510 (1989) and KEPIC-MH (2001) to enhance the removal efficiency of aerosols and particulates from the effluents. The revised ACU testing criteria are allowed to use alternative challenge agents of the dioctyl phthalate and Refrigerant-11 for in situ testing of high efficiency particulate air filters and adsorption banks. The operability testing time of engineered safety feature (ESF) trains was changed from 10 h to 15 min. The activated carbon in adsorption banks should undergo laboratory tests at a temperature of 30 °C and relative humidity 95 %. The removal criteria of methyl iodide should be over 99.5 % for ESF and 99 % for normal systems. This paper provides the background of the changed criteria for designing and testing of the ACU system in nuclear facilities. PMID:21502294

  1. Les facteurs prédictifs de morbimortalité chez les patients sous ballon de contre pulsion intra-aortique en chirurgie cardiaque

    PubMed Central

    Elahmadi, Brahim; Motiaa, Youssef; Hatim, Abdedaim Elghadbane; Atmani, Noureddine; Moutakillah, Younes; Wahid, Fouad Amal; Elbekkali, Youssef; Houssa, Mahdi Ait; Razine, Rachid; Boulahya, Abdelatif; Drissi, Mohammed

    2015-01-01

    Le ballon de contre pulsion intra-aortique (BCPIA) est fréquemment utilisé en chirurgie cardiaque, comme moyen d'assistance circulatoire en cas de bas débit cardiaque. Il est d'intérêt clinique de déterminer les facteurs pronostiques chez les patients porteurs d'un BCPIA en chirurgie cardiaque, et qui restent un sujet rarement élucidé dans la littérature. L'objectif de notre travail est de déterminer les facteurs prédictifs de morbi-mortalité chez les patients sous ballon de contre pulsion intraortique en périopératoire d'une chirurgie cardiaque. Il s'agit d'une étude rétrospective portant sur l'ensemble des patients opérés en chirurgie cardiaque sous circulation extracorporelle, et ayant bénéficiés de la mise en place d'un ballon de contre pulsion intra-aortique en périopératoire, au service de chirurgie cardiovasculaire de l'Hôpital Militaire Mohamed V de Rabat, entre le mois de janvier 2005 et le mois d'aout 20014. Soixante dix patients ont été inclus dans notre étude. En analyse univariée l'âge, la dyspnée de stade III et IV, l'insuffisance cardiaque, la présence d'un infarctus du myocarde, d'une coronaropathie mono et bitronculaire, les anomalies du doppler de trons supra-aortique et du membre inférieur, le caractère urgent de la chirurgie, la durée de la circulation extracorporelle, l'instabilité hémodynamique postopératoire, le saignement et l'insuffisance rénale postopératoire étaient statistiquement associés à une mortalité postopératoire élevée. La dyskinésie préopératoire et la sortie de circulation extracorporelle sous drogues étaient associées à une morbidité globale élevée. En analyse multi variée, seule l'âge, constituait un facteur de risque indépendant de mortalité dans notre série avec un Odds Ratio (OR): 1,89 ; un Intervalle de Confiance (IC) 95% de (1,52-4,97) et un p =0,045. Au terme de notre étude, le taux de mortalité était de 48,57% et de morbidité globale était de 87,1%. Il

  2. 15 CFR 781.3 - Scope of the APR.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Agreement Between the United States of America and the International Atomic Energy Agency Concerning the Application of Safeguards in the United States of America, known as the Additional Protocol. (a) Persons and... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false Scope of the APR. 781.3 Section...

  3. 14 CFR Appendix H to Part 23 - Installation of An Automatic Power Reserve (APR) System

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... intersection of the engine and APR failure flight path line with the minimum performance all engine flight path line. The engine and APR failure flight path line intersects the one-engine-inoperative flight path line at 400 feet above the takeoff surface. The engine and APR failure flight path is based on...

  4. 14 CFR Appendix H to Part 23 - Installation of An Automatic Power Reserve (APR) System

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... intersection of the engine and APR failure flight path line with the minimum performance all engine flight path line. The engine and APR failure flight path line intersects the one-engine-inoperative flight path line at 400 feet above the takeoff surface. The engine and APR failure flight path is based on...

  5. Chirurgie angeborener Herzfehler

    NASA Astrophysics Data System (ADS)

    Schreiber, Christian; Libera, Paul; Lange, Rüdiger

    Störungen der embryonalen Entwicklung in der frühen Phase der Schwangerschaft können zu Fehlbildungen am Herz- und Gefäßsystem führen. Die Häufigkeit liegt bei 0.8-1 % aller lebend geborenen Kinder. In Deutschland werden jedes Jahr etwa 6.000 Kinder mit einem Herzfehler geboren (Quelle: http://www.kompetenznetzahf.de). Das Spektrum reicht von einfachen Fehlern, die das Herz-Kreislauf-System wenig beeinträchtigen, bis zu sehr schweren Herzerkrankungen, die unbehandelt zum Tode führen. Fortschritte der Kinderkardiologie, Herzchirurgie und Anästhesie ermöglichen heute ein Überleben bei über 90 % der Patienten. Auch die spezialisierte Pränataldiagnostik (vorgeburtliche Diagnostik) ermöglicht schon die frühe Weichenstellung für mögliche Therapieoptionen. Bei der chirurgischen Therapie ist jedoch festzuhalten, dass ein Herzfehler entweder korrigierend behandelt wird oder nur "palliiert“ werden kann. Bei letzterer Therapie wird bei einem Patienten eine medizinische Maßnahme durchgeführt, die nicht die Herstellung normaler Körperfunktionen zum Ziel hat, sondern in Anpassung an die physiologischen Besonderheiten des Patienten dessen Zustand lediglich stabilisiert und optimiert. Dies kann beispielsweise bei einer nicht korrigierbaren angeborenen Fehlbildung notwendig sein, bei der lediglich eine funktionelle Herzkammer vorhanden ist (z. B. hypoplastisches Linksherz). Hierbei muss eine prothetische Verbindung zur Lungenstrombahn in der Folgezeit entfernt werden.

  6. Review of APR+ Level 2 PSA. Revision 2

    SciTech Connect

    Lehner, John R.; Mubayi, Vinod; Pratt, W. Trevor; Kim, Do Sam; Cho, Yong Jin; Cho, Sang Jin; Kim, In Goo

    2012-02-17

    Brookhaven National Laboratory (BNL) assisted the Korea Institute of Nuclear Safety (KINS) in reviewing the Level 2 Probabilistic Safety Assessment (PSA) of the APR+ Advanced Pressurized Water Reactor (PWR) prepared by the Korea Hydro & Nuclear Power Co., Ltd (KHNP) and KEPCO Engineering & Construction Co., Inc. (KEPCO-E&C). The work described in this report involves a review of the APR+ Level 2 PSA submittal [Ref. 1]. The PSA and, therefore, the review is limited to consideration of accidents initiated by internal events. As part of the review process, the review team also developed three sets of Requests for Additional Information (RAIs). These RAIs were provided to KHNP and KEPCO-E&C for their evaluation and response. This final detailed report documents the review findings for each technical element of the PSA and includes consideration of all of the RAIs made by the reviewers as well as the associated responses. This final report was preceded by an interim report [Ref. 2] that focused on identifying important issues regarding the PSA. In addition, a final meeting on the project was held at BNL on November 21-22, 2011, where BNL and KINS reviewers discussed their preliminary review findings with KHNP and KEPCO-E&C staffs. Additional information obtained during this final meeting was also used to inform the review findings of this final report. The review focused not only on the robustness of the APR+ design to withstand severe accidents, but also on the capability and acceptability of the Level 2 PSA in terms of level of detail and completeness. The Korean nuclear regulatory authorities will decide whether the PSA is acceptable and the BNL review team is providing its comments for KINS consideration. Section 2.0 provides the basis for the BNL review. Section 3.0 presents the review of each technical element of the PSA. Conclusions and a summary are presented in Section 4.0. Section 5.0 contains the references.

  7. Apr3 accelerates the senescence of human retinal pigment epithelial cells.

    PubMed

    Han, Song; Lu, Qingjun; Wang, Ningli

    2016-04-01

    Senescence of retinal pigment epithelium (RPE) cells is a major contributor to age‑related macular degeneration (AMD). However, the molecular mechanisms underlying RPE dysfunction are not well understood. Apoptosis related protein 3 (Apr3) was originally cloned from HL‑60 cells induced by all‑trans retinoic acid (ATRA). Preliminary data revealed elevated Apr3 expression in the tissues of aged mice, suggesting that it is involved in the aging process. The present study demonstrated that Apr3 mRNA and protein levels were markedly increased in aged mouse RPE cells. Elevated Apr3 expression was also observed during premature senescence induced by oxidative stress (H2O2 and tert‑BHP) in ARPE‑19 cells. Moreover, Apr3 overexpression promoted cellular senescence in ARPE‑19 cells, as characterized by enhanced senescence‑associated β‑galactosidase activity, reduced cell proliferation and increased expression of the senescence markers p53 and p21. In addition, it was demonstrated that overexpression of Apr3‑N, a truncated counterpart of Apr3, abrogated Apr3‑induced phenotypes. It was concluded that Apr3 expression was induced in replicative and premature senescence of RPE cells and its overexpression accelerated senescence of ARPE‑19 cells, which provides important insights into the function of Apr3 in senescence‑associated diseases. PMID:26934949

  8. Evaluation de la formation des résidents en chirurgie générale et digestive en Tunisie

    PubMed Central

    Mahmoudi, Ammar; Noomen, Faouzi; Nasr, Mohamed; Zouari, Khadija; Hamdi, Abdelaziz

    2015-01-01

    Introduction De nombreux moyens sont mis à disposition des résidents en chirurgie générale et digestive pour assurer leur formation théorique et pratique. Cependant, le niveau d'utilisation de ces différents outils et leur impact sur la formation des résidents n'ont jamais été évalués. L'objectif de notre étude était d’étudier l’état des lieux des moyens de formation utilisés par les résidents pour évaluer leurs degrés de satisfaction et leurs propositions en vue d'améliorer leur formation. Méthodes Un questionnaire anonyme a été distribué aux résidents de chirurgie générale et digestive de l'année 2012-2013. Ce questionnaire portait sur les caractéristiques démographiques, les ressources pédagogiques, ainsi que le cursus médical et universitaire. Une évaluation de la formation ainsi qu'un recueil des propositions faites en vue d'améliorer leurs formations étaient réalisées. Résultats Cinquante résidents sur 83 ont répondu au questionnaire. L'orientation de carrière la plus fréquente était l'hospitalo-universitaire dans 70% des cas. La pratique quotidienne et l'internet étaient les deux ressources pédagogiques les plus utilisées. La formation chirurgicale était jugée satisfaisante par seulement 10% des répondants. Parmi l'ensemble des propositions faites, l'apprentissage sur simulateur chirurgical, l'existence d'un ouvrage national de référence, et l'institution d'un tutorat par un chirurgien senior recueillaient plus de 80% d'avis favorable. Conclusion La majorité des résidents jugent leur formation non satisfaisante. Une meilleure information sur les ressources déjà existantes, un renforcement du compagnonnage et un accès plus large à un apprentissage sur simulateur chirurgical permettraient de diminuer ce sentiment d'insatisfaction. PMID:26587174

  9. Pseudomonas syringae evades host immunity by degrading flagellin monomers with alkaline protease AprA.

    PubMed

    Pel, Michiel J C; van Dijken, Anja J H; Bardoel, Bart W; Seidl, Michael F; van der Ent, Sjoerd; van Strijp, Jos A G; Pieterse, Corné M J

    2014-07-01

    Bacterial flagellin molecules are strong inducers of innate immune responses in both mammals and plants. The opportunistic pathogen Pseudomonas aeruginosa secretes an alkaline protease called AprA that degrades flagellin monomers. Here, we show that AprA is widespread among a wide variety of bacterial species. In addition, we investigated the role of AprA in virulence of the bacterial plant pathogen P. syringae pv. tomato DC3000. The AprA-deficient DC3000 ΔaprA knockout mutant was significantly less virulent on both tomato and Arabidopsis thaliana. Moreover, infiltration of A. thaliana Col-0 leaves with DC3000 ΔaprA evoked a significantly higher level of expression of the defense-related genes FRK1 and PR-1 than did wild-type DC3000. In the flagellin receptor mutant fls2, pathogen virulence and defense-related gene activation did not differ between DC3000 and DC3000 ΔaprA. Together, these results suggest that AprA of DC3000 is important for evasion of recognition by the FLS2 receptor, allowing wild-type DC3000 to be more virulent on its host plant than AprA-deficient DC3000 ΔaprA. To provide further evidence for the role of DC3000 AprA in host immune evasion, we overexpressed the AprA inhibitory peptide AprI of DC3000 in A. thaliana to counteract the immune evasive capacity of DC3000 AprA. Ectopic expression of aprI in A. thaliana resulted in an enhanced level of resistance against wild-type DC3000, while the already elevated level of resistance against DC3000 ΔaprA remained unchanged. Together, these results indicate that evasion of host immunity by the alkaline protease AprA is important for full virulence of strain DC3000 and likely acts by preventing flagellin monomers from being recognized by its cognate immune receptor. PMID:24654978

  10. [A century since the publication of Grossich's paper in Zentralblatt für Chirurgie--an innovation in the field of antisepsis].

    PubMed

    Petaros, A; Skrobonja, A

    2010-06-01

    This review recalls the first presentation of a modified method for the use of iodine tincture in preoperative disinfection of skin and minor injuries by the Rijeka physician Antonio Grossich (1849-1926), which was published in "Zentralblatt für Chirurgie" 100 years ago. It did not have to wait long before it received acclaim from 20 other medical journals, and in 1909, from the audience at the International Surgery Congress held in Budapest for an extended presentation on the subject. In the following 2 years, surgeons all over the world published their experiences with this optimised technique in over a hundred journals. Doctor Grossich put these articles together and published them with his commentary in 1911 in a monograph entitled "Meine Präparationsmethode des Operationsfelds mittels Jodtinktur" (English: "My personal approach for the preparation of the surgical field using iodine tincture"). Although iodine tincture was also used by other physicians and surgeons at that time, Grossich optimised the method for its use, and he was the first to publish his experience in surgical practice. PMID:20549591

  11. 14 CFR Appendix H to Part 23 - Installation of An Automatic Power Reserve (APR) System

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Installation of An Automatic Power Reserve (APR) System H Appendix H to Part 23 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT... AIRPLANES Pt. 23, App. H Appendix H to Part 23—Installation of An Automatic Power Reserve (APR) System...

  12. Fuel assembly design for APR1400 with low CBC

    SciTech Connect

    Hah, Chang Joo

    2015-04-29

    APR 1400 is a PWR (Pressurized Water Reactor) with rated power of 3983 MWth and 241 assemblies. Recently, demand for extremely longer cycle up to 24 months is increasing with challenge of higher critical boron concentration (CBC). In this paper, assembly design method of selecting Gd-rods is introduced to reduce CBC. The purpose of the method is to lower the critical boron concentration of the preliminary core loading pattern (PLP), and consequently to achieve more negative or less positive moderator temperature coefficient (MTC). In this method, both the ratio of the number of low-Gd rod to the number of high-Gd rod (r) and assembly average Gd wt% (w) are the decision variables. The target function is the amount of soluble boron concentration reduction, which can be converted to Δk{sub TARGET}. A set of new designed fuel assembly satisfies an objective function, min [f=∑{sub i}(Δk{sub FA}−Δk{sub i})], and enables a final loading pattern to reach a target CBC. The constraints required to determine a set of Δk are physically realizable pair, (r,w), and the sum of Δk of new designed assemblies as close to Δk{sub TARGET} as possible. New Gd-bearing assemblies selected based on valid pairs of (r,w) are replaced with existing assemblies in a PLP. This design methodology is applied to Shin-Kori Unit 3 Cycle 1 used as a reference model. CASMO-3/MASTER code is used for depletion calculation. CASMO-3/MASTER calculations with new designed assemblies produce lower CBC than the expected CBC, proving that the proposed method works successful.

  13. Fuel assembly design for APR1400 with low CBC

    NASA Astrophysics Data System (ADS)

    Hah, Chang Joo

    2015-04-01

    APR 1400 is a PWR (Pressurized Water Reactor) with rated power of 3983 MWth and 241 assemblies. Recently, demand for extremely longer cycle up to 24 months is increasing with challenge of higher critical boron concentration (CBC). In this paper, assembly design method of selecting Gd-rods is introduced to reduce CBC. The purpose of the method is to lower the critical boron concentration of the preliminary core loading pattern (PLP), and consequently to achieve more negative or less positive moderator temperature coefficient (MTC). In this method, both the ratio of the number of low-Gd rod to the number of high-Gd rod (r) and assembly average Gd wt% (w) are the decision variables. The target function is the amount of soluble boron concentration reduction, which can be converted to ΔkTARGET. A set of new designed fuel assembly satisfies an objective function, min [f =∑i (ΔkF A-Δki ) ] , and enables a final loading pattern to reach a target CBC. The constraints required to determine a set of Δk are physically realizable pair, (r,w), and the sum of Δk of new designed assemblies as close to ΔkTARGET as possible. New Gd-bearing assemblies selected based on valid pairs of (r,w) are replaced with existing assemblies in a PLP. This design methodology is applied to Shin-Kori Unit 3 Cycle 1 used as a reference model. CASMO-3/MASTER code is used for depletion calculation. CASMO-3/MASTER calculations with new designed assemblies produce lower CBC than the expected CBC, proving that the proposed method works successful.

  14. 82. Neg. No. F66A, Apr 13, 1930, INTERIORASSEMBLY BUILDING, TRIM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    82. Neg. No. F-66A, Apr 13, 1930, INTERIOR-ASSEMBLY BUILDING, TRIM LINE AND GLASS DEPARTMENTS - Ford Motor Company Long Beach Assembly Plant, Assembly Building, 700 Henry Ford Avenue, Long Beach, Los Angeles County, CA

  15. 77. Neg. No. F65A, Apr 13, 1930, INTERIORASSEMBLY BUILDING, UNLOADING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    77. Neg. No. F-65A, Apr 13, 1930, INTERIOR-ASSEMBLY BUILDING, UNLOADING THE ENAMEL OVEN - Ford Motor Company Long Beach Assembly Plant, Assembly Building, 700 Henry Ford Avenue, Long Beach, Los Angeles County, CA

  16. 76. Neg. No. F58, Apr 13, 1930, INTERIORASSEMBLY BUILDING, BURNOFF, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    76. Neg. No. F-58, Apr 13, 1930, INTERIOR-ASSEMBLY BUILDING, BURNOFF, LOAD END OF ENAMEL OVEN - Ford Motor Company Long Beach Assembly Plant, Assembly Building, 700 Henry Ford Avenue, Long Beach, Los Angeles County, CA

  17. 78. Neg. No. F143A, Apr 1, 1932, INTERIORASSEMBLY BUILDING, CONVEYOR ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    78. Neg. No. F-143A, Apr 1, 1932, INTERIOR-ASSEMBLY BUILDING, CONVEYOR LINE WITH CAR CHASSIS - Ford Motor Company Long Beach Assembly Plant, Assembly Building, 700 Henry Ford Avenue, Long Beach, Los Angeles County, CA

  18. 81. Neg. No. F63, Apr 13, 1930, INTERIORASSEMBLY BUILDING, HOOD ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    81. Neg. No. F-63, Apr 13, 1930, INTERIOR-ASSEMBLY BUILDING, HOOD DEPARTMENT - Ford Motor Company Long Beach Assembly Plant, Assembly Building, 700 Henry Ford Avenue, Long Beach, Los Angeles County, CA

  19. 83. Neg. No. F53, Apr 13, 1930, INTERIORASSEMBLY BUILDING, BACK ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    83. Neg. No. F-53, Apr 13, 1930, INTERIOR-ASSEMBLY BUILDING, BACK TRIM LINE - Ford Motor Company Long Beach Assembly Plant, Assembly Building, 700 Henry Ford Avenue, Long Beach, Los Angeles County, CA

  20. 90. Neg. No. F59A, Apr 13, 1930, INTERIORASSEMBLY BUILDING, CHASSIS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    90. Neg. No. F-59A, Apr 13, 1930, INTERIOR-ASSEMBLY BUILDING, CHASSIS LINE, LOOKING SOUTH - Ford Motor Company Long Beach Assembly Plant, Assembly Building, 700 Henry Ford Avenue, Long Beach, Los Angeles County, CA

  1. 84. Neg. No. F62, Apr 13, 1930, INTERIORASSEMBLY BUILDING, FRAME ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    84. Neg. No. F-62, Apr 13, 1930, INTERIOR-ASSEMBLY BUILDING, FRAME AND MOTOR STORAGE CONVEYOR - Ford Motor Company Long Beach Assembly Plant, Assembly Building, 700 Henry Ford Avenue, Long Beach, Los Angeles County, CA

  2. Current status of integrated HFE V and V system of APR1400

    SciTech Connect

    Lee, M. S.; Hong, J. H.; Lee, S. H.; Lee, Y. K.

    2006-07-01

    The first Advanced Light Water Reactor called Advanced Power Reactor (APR1400) has many specific features such as passive safety features, digital I and C, and digitalized main control room design. This digital-based neo-concept main control room design needs comprehensive verification and validation process to get the license for construction. An integrated system for APR1400 MMIS design validation is under development by KEPRI with the participating of KHNP. The facility which is based on the NUREG/CR-6393 and ANS3.5 can simulate all of the dynamic functions and responses of APR1400, and measure the human factors by using conventional subject methods and measuring the operator's biological signals. This system will be used in human factors V and V process of the PRM (NUREG0711) of APR1400 MMIS design. (authors)

  3. 85. Neg. No. F51, Apr 13, 1930, INTERIORASSEMBLY BUILDING, BODY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    85. Neg. No. F-51, Apr 13, 1930, INTERIOR-ASSEMBLY BUILDING, BODY AND CUSHION LINE - Ford Motor Company Long Beach Assembly Plant, Assembly Building, 700 Henry Ford Avenue, Long Beach, Los Angeles County, CA

  4. 79. Neg. No. F61A, Apr 13, 1930, INTERIORASSEMBLY BUILDING, BODY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    79. Neg. No. F-61A, Apr 13, 1930, INTERIOR-ASSEMBLY BUILDING, BODY CONSTRUCTION - Ford Motor Company Long Beach Assembly Plant, Assembly Building, 700 Henry Ford Avenue, Long Beach, Los Angeles County, CA

  5. 86. Neg. No. F64, Apr 13, 1930, INTERIORASSEMBLY BUILDING, BODY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    86. Neg. No. F-64, Apr 13, 1930, INTERIOR-ASSEMBLY BUILDING, BODY STORAGE CONVEYOR - Ford Motor Company Long Beach Assembly Plant, Assembly Building, 700 Henry Ford Avenue, Long Beach, Los Angeles County, CA

  6. 15 CFR 782.1 - Overview of reporting requirements under the APR.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE ADDITIONAL PROTOCOL... (see § 782.5 of the APR). In addition, forms may be downloaded from the Internet at http://www.ap.gov....

  7. 15 CFR 782.5 - Where to obtain APR report forms.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE ADDITIONAL PROTOCOL REGULATIONS GENERAL... forms required by the APR may be downloaded from the Internet at http://www.ap.gov. You also may...

  8. Reliability enhancement of APR + diverse protection system regarding common cause failures

    SciTech Connect

    Oh, Y. G.; Kim, Y. M.; Yim, H. S.; Lee, S. J.

    2012-07-01

    The Advanced Power Reactor Plus (APR +) nuclear power plant design has been developed on the basis of the APR1400 (Advanced Power Reactor 1400 MWe) to further enhance safety and economics. For the mitigation of Anticipated Transients Without Scram (ATWS) as well as Common Cause Failures (CCF) within the Plant Protection System (PPS) and the Emergency Safety Feature - Component Control System (ESF-CCS), several design improvement features have been implemented for the Diverse Protection System (DPS) of the APR + plant. As compared to the APR1400 DPS design, the APR + DPS has been designed to provide the Safety Injection Actuation Signal (SIAS) considering a large break LOCA accident concurrent with the CCF. Additionally several design improvement features, such as channel structure with redundant processing modules, and changes of system communication methods and auto-system test methods, are introduced to enhance the functional reliability of the DPS. Therefore, it is expected that the APR + DPS can provide an enhanced safety and reliability regarding possible CCF in the safety-grade I and C systems as well as the DPS itself. (authors)

  9. Evaluation of APR1 Gene Expression in Candida albicans Strains Isolated From Patients With Multiple Sclerosis

    PubMed Central

    Amri Saroukolaei, Shahla; Ghabaee, Mojdeh; Shokri, Hojjatollah; Khosravi, Alireza; Badiei, Alireza

    2016-01-01

    Background Intracellular aspartic proteinase A enzyme is expressed by the APR1 gene and is one of the important factors in the development of systemic candidiasis caused by Candida albicans. Objectives The aim of this study was to evaluate the expression of the APR1 gene in C. albicans isolates obtained from patients with multiple sclerosis (MS) and from controls. Patients and Methods The samples were obtained from 135 MS patients with candidiasis and 100 matched controls of healthy individuals during 2010 - 2011. The clinical and control isolates of C. albicans obtained from individuals were cultured onto sabouraud dextrose agar (SDA). The evaluation of APR1 gene expression was performed using the reverse transcriptase-polymerase chain reaction (RT-PCR) method. Results There was a statistically significant difference in APR1 gene expression of C. albicans strains between MS patients (mean ± SD: 0.5208 ± 0.11518) and the control group (mean ± SD: 0.7603 ± 0.11405) (P = 0.000). Significant correlations were found between the APR1 gene expression of C. albicans strains from MS patients with regard to age and the expanded disability status scale (EDSS) (P = 0.000). The mean values of EDSS were 1.6074 ± 0.1081 after antifungal treatment and 2.2519 ± 0.1323 before antifungal treatment (P = 0.000). No significant correlation was observed between the APR1 gene expression with regard to sex and MS subtypes. Conclusions The results suggested that APR1 gene expression in C. albicans strains isolated from MS patients may be an important factor for invasive C. albicans strains in the progression of MS disease. PMID:27540458

  10. 15 CFR 781.1 - Definitions of terms used in the Additional Protocol Regulations (APR).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Definitions of terms used in the Additional Protocol Regulations (APR). 781.1 Section 781.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE ADDITIONAL PROTOCOL REGULATIONS...

  11. 15 CFR 781.1 - Definitions of terms used in the Additional Protocol Regulations (APR).

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false Definitions of terms used in the Additional Protocol Regulations (APR). 781.1 Section 781.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE ADDITIONAL PROTOCOL REGULATIONS...

  12. 15 CFR 781.1 - Definitions of terms used in the Additional Protocol Regulations (APR).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 2 2012-01-01 2012-01-01 false Definitions of terms used in the Additional Protocol Regulations (APR). 781.1 Section 781.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE ADDITIONAL PROTOCOL REGULATIONS...

  13. 15 CFR 781.1 - Definitions of terms used in the Additional Protocol Regulations (APR).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false Definitions of terms used in the Additional Protocol Regulations (APR). 781.1 Section 781.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE ADDITIONAL PROTOCOL REGULATIONS...

  14. 91. Neg. No. F174A, Apr 24, 1936, INTERIORASSEMBLY BUILDING, FINISHED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    91. Neg. No. F-174A, Apr 24, 1936, INTERIOR-ASSEMBLY BUILDING, FINISHED CARS AT THE END OF THE ASSEMBLY LINE - Ford Motor Company Long Beach Assembly Plant, Assembly Building, 700 Henry Ford Avenue, Long Beach, Los Angeles County, CA

  15. 14 CFR Appendix H to Part 23 - Installation of An Automatic Power Reserve (APR) System

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... failure, transmit signals, actuate fuel controls or power levers on operating engines, including power... power lever position; and (c) That shown to be free of hazardous engine response characteristics when...; (3) Prevent deactivation of the APR by manual adjustment of the power levers following an...

  16. 15 CFR 782.5 - Where to obtain APR report forms.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE ADDITIONAL PROTOCOL REGULATIONS GENERAL INFORMATION REGARDING REPORTING REQUIREMENTS AND PROCEDURES § 782.5 Where to obtain APR report forms. Report... these forms by contacting: Treaty Compliance Division, Bureau of Industry and Security, U.S....

  17. 15 CFR 782.5 - Where to obtain APR report forms.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE ADDITIONAL PROTOCOL REGULATIONS GENERAL INFORMATION REGARDING REPORTING REQUIREMENTS AND PROCEDURES § 782.5 Where to obtain APR report forms. Report... these forms by contacting: Treaty Compliance Division, Bureau of Industry and Security, U.S....

  18. 15 CFR 782.5 - Where to obtain APR report forms.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE ADDITIONAL PROTOCOL REGULATIONS GENERAL INFORMATION REGARDING REPORTING REQUIREMENTS AND PROCEDURES § 782.5 Where to obtain APR report forms. Report... these forms by contacting: Treaty Compliance Division, Bureau of Industry and Security, U.S....

  19. 48 CFR 1552.235-79 - Release of contractor confidential business information (APR 1996).

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Release of contractor confidential business information (APR 1996). 1552.235-79 Section 1552.235-79 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of Provisions and Clauses...

  20. 48 CFR 1552.235-79 - Release of contractor confidential business information (APR 1996).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Release of contractor confidential business information (APR 1996). 1552.235-79 Section 1552.235-79 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of Provisions and Clauses...

  1. 14 CFR Appendix H to Part 23 - Installation of An Automatic Power Reserve (APR) System

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... failure, transmit signals, actuate fuel controls or power levers on operating engines, including power... power lever position; and (c) That shown to be free of hazardous engine response characteristics when...; (3) Prevent deactivation of the APR by manual adjustment of the power levers following an...

  2. Privacy Impact Assessment for the TRIO Programs Annual Performance Report (APR) System

    ERIC Educational Resources Information Center

    US Department of Education, 2008

    2008-01-01

    The TRIO Programs Annual Performance Report (APR) System collects individual student records on individuals served by the following Federal TRIO Programs: Upward Bound (which includes regular Upward Bound (UB), Upward Bound Math-Science (UBMS), and Veterans Upward Bound (VUB)); Student Support Services (SSS); and the Ronald E. McNair Post…

  3. Using a Classroom Response System to Improve Multiple-Choice Performance in AP[R] Physics

    ERIC Educational Resources Information Center

    Bertrand, Peggy

    2009-01-01

    Participation in rigorous high school courses such as Advanced Placement (AP[R]) Physics increases the likelihood of college success, especially for students who are traditionally underserved. Tackling difficult multiple-choice exams should be part of any AP program because well-constructed multiple-choice questions, such as those on AP exams and…

  4. The 6th Annual AP[R] Report to the Nation

    ERIC Educational Resources Information Center

    College Board, 2010

    2010-01-01

    Educators across the United States continue to enable a wider and more ethnically diverse proportion of students to achieve success in AP[R]. Significant inequities remain, however, which can result in traditionally underserved students not receiving the type of AP (Advanced Placement) opportunities that can best prepare them for college success.…

  5. 23. "GAFFTC 20 APR 60, H65A F106A; ESCAPE SYSTEM RUN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. "G-AFFTC 20 APR 60, H-6-5A F-106A; ESCAPE SYSTEM RUN 5A." Testing the ejection system on a Convair sled. - Edwards Air Force Base, South Base Sled Track, Edwards Air Force Base, North of Avenue B, between 100th & 140th Streets East, Lancaster, Los Angeles County, CA

  6. Annual Personnel Report (APR) Data Base Data Element Dictionary, 1999-2000.

    ERIC Educational Resources Information Center

    Florida State Board of Community Colleges, Tallahassee.

    The document comprises the data element dictionary for the Annual Personnel Report (APR) Data Base (Version 8.0), 1999-2000, for the Florida Community College System (FCCS). The Annual Personnel Reports System was created to meet federal and state requirements for reporting personnel information. The key fields are listed at the top of the table…

  7. Les complications abdominales associées à la chirurgie cardiaque : à propos d'une expérience chirurgicale contemporaine et examen d'une population opérée sans circulation extracorporelle

    PubMed Central

    Poirier, Brigitte; Baillot, Richard; Bauset, Richard; Dagenais, François; Mathieu, Patrick; Simard, Serge; Dionne, Brigitte; Caouette, Manon; Hould, Frédéric-Simon; Doyle, Daniel; Poirier, Paul

    2003-01-01

    Introduction Pour évaluer l'incidence, les facteurs de risque et la morbidité associés aux complications gastro-intestinales (GI) suite à une chirurgie cardiaque avec ou sans circulation extra-corporelle (CEC), nous avons effectué une étude rétrospective de cohortes dans un hôpital universitaire. Méthodes 11 405 patients adultes répartis en 2 groupes : groupe A (de janvier 1992 à juin 1996, 4657 patients) et groupe B (de juillet 1996 à décembre 2000, 6748 patients). Résultats 134 patients (1,2 %) ont présenté 147 complications. Le pourcentage des événements GI fut identique pour les 2 groupes (groupe A, n = 59/4657 [1,2 %]; groupe B, n = 75/6748 [1,1 %]). Le groupe B était composé de patients plus âgés, obèses, diabétiques ayant une maladie vasculaire cérébrale et périphérique. Les complications les plus fréquentes sont associées à l'œsophage et l'estomac, n = 67/147 (45,5 %). Nous identifions à la suite 10 (6,8 %) cholécystites, 13 (8,8 %) pancréatites, 17 (11,6 %) atteintes ischémiques du grêle et du colon, 12 (8,2 %) colites pseudomembraneuses et 5 (3,4 %) diverticulites. L'ischémie mésentérique est responsable de 11 (37,9 %) des 29 décès; 293 patients ont subi une revascularisation myocardique à cœur battant. Cinq patients (1,7 %) ont présenté des complications GI dont trois avec ischémie viscérale. L'analyse multivariée démontre que l'insuffisance rénale, l'intubation prolongée et l'infection sont associées aux complications GI dans les deux groupes alors que le score de Parsonnet et l'accident vasculaire cérébral apparaissent prédictifs dans le second groupe. Conclusions Ces résultats démontent que le nombre de patients qui présentent des complications GI lors d'une chirurgie cardiaque n'augmente pas malgré le caractère sénescent et la co-morbidité. La chirurgie coronarienne pratiquée sans CEC ne semble pas diminuer l'incidence des complications GI. PMID:12812238

  8. EURAPS at 20 years. A brief history of European Plastic Surgery from the Société Européenne de Chirurgie Structive to the European Association of Plastic Surgeons (EURAPS).

    PubMed

    Mazzola, Riccardo F; Kon, Moshe

    2010-06-01

    By the end of WWI, plastic surgery had reached unexpected heights. The high quality of the work done for soldiers with facial injuries and burns, either as an emergency or as a delayed procedure, demonstrated that this new discipline was honourable, worthwhile and socially crucial, thus deserving official recognition and independence. The establishment of new plastic surgery centres, scientific societies and specialised journals were the key to success for the achievement of this goal. In 1936, the Belgian Maurice Coelst (1894-1963) founded the Société Européenne de Chirurgie Structive, the first supranational society, with the aim of gathering once a year all those interested in this new branch of surgery and favouring confrontation of ideas by showing innovative clinical procedures. The very successful first Congress with a large international participation was held in Brussels, with Coelst as the president, the second in London, in 1937, organised by Kilner and the third in Milano, in 1938, arranged by Sanvenero Rosselli. Even live surgery was performed during the meetings. The beginning of the WWII stopped the Societé's activities, which were never resumed. In the late 1980s, when plastic surgery reached its zenith, the necessity was felt to create a new supranational society, different in its purpose from the existing European Section of IPRAS, later European Society of Plastic Reconstructive and Aesthetic Surgery (ESPRAS), an organisation where all the official European plastic surgery societies merged automatically. The aim was to promote the excellence of plastic surgery in Europe, to furnish an annual forum for the selection of the best scientific works presented at national societies and to stimulate research and education at a European level. Established in 1989, 53 years after the foundation of the Société Européenne de Chirurgie Structive, it was named the European Association of Plastic Surgeons (EURAPS). The first scientific meeting took place

  9. Chirurgie coronaire isolée chez l’octogénaire : Résultats immédiats et analyse du taux de survie et de la qualité de vie à long terme

    PubMed Central

    Bach, Vincent; Tramaille, Sophie; Chavanon, Olivier; Durand, Michel; Noirclerc, Marianne; Vesin, Claire; Porcu, Paolo; Hacini, Rachid; Vanzetto, Gérald; Machecourt, Jacques

    2008-01-01

    HISTORIQUE : Près de trois millions d’octogénaires vivent en France, et ils sont nombreux à présenter une coronaropathie. Par ailleurs, l’espérance de vie à 80 ans semble encore importante. OBJECTIF : Évaluer les résultats d’une chirurgie coronaire chez ces patients. MÉTHODOLOGIE : Nous avons comparé 88 patients octogénaires consécutifs ayant subi un pontage aortocoronarien isolé entre 1996 et 2002 à 165 patients de 60 à 70 ans. Les deux groupes ont été appariés selon les principaux facteurs de risque. Nous avons pris contact avec les patients par téléphone et leur avons fait parvenir un questionnaire sur la qualité de vie. RÉSULTATS : La mortalité opératoire s’élevait à 2,3 % chez les octogénaires, par rapport à 1,2 % chez les 60 à 70 ans (P non significatif). Il y avait plus de bas débit, d’insuffisance rénale aiguë postopératoire et de transfusion chez les octogénaires. La survie à long terme (durée moyenne du suivi de 3,8 ans) était plus élevée chez les 60 à 70 ans : 89,7 % par rapport à 77,9 % (P=0,025). Nous avons constaté quatre facteurs de risque indépendants d’augmentation de la mortalité à long terme; âge, diabète, antécédents d’accident vasculaire cérébral et de transfusion sanguine postopératoire. Enfin, la survie à long terme des octogénaires opérés était significativement plus élevée que celle des octogénaires de la population générale de France, et leur qualité de vie était considérée comme satisfaisante. CONCLUSION : Pour des octogénaires sélectionnés, on peut proposer une chirurgie coronaire isolée, et les résultats à court et à long terme seront comparables à ceux d’une population plus jeune. PMID:18841258

  10. Assistant Personal Robot (APR): Conception and Application of a Tele-Operated Assisted Living Robot

    PubMed Central

    Clotet, Eduard; Martínez, Dani; Moreno, Javier; Tresanchez, Marcel; Palacín, Jordi

    2016-01-01

    This paper presents the technical description, mechanical design, electronic components, software implementation and possible applications of a tele-operated mobile robot designed as an assisted living tool. This robotic concept has been named Assistant Personal Robot (or APR for short) and has been designed as a remotely telecontrolled robotic platform built to provide social and assistive services to elderly people and those with impaired mobility. The APR features a fast high-mobility motion system adapted for tele-operation in plain indoor areas, which incorporates a high-priority collision avoidance procedure. This paper presents the mechanical architecture, electrical fundaments and software implementation required in order to develop the main functionalities of an assistive robot. The APR uses a tablet in order to implement the basic peer-to-peer videoconference and tele-operation control combined with a tactile graphic user interface. The paper also presents the development of some applications proposed in the framework of an assisted living robot. PMID:27136552

  11. Assistant Personal Robot (APR): Conception and Application of a Tele-Operated Assisted Living Robot.

    PubMed

    Clotet, Eduard; Martínez, Dani; Moreno, Javier; Tresanchez, Marcel; Palacín, Jordi

    2016-01-01

    This paper presents the technical description, mechanical design, electronic components, software implementation and possible applications of a tele-operated mobile robot designed as an assisted living tool. This robotic concept has been named Assistant Personal Robot (or APR for short) and has been designed as a remotely telecontrolled robotic platform built to provide social and assistive services to elderly people and those with impaired mobility. The APR features a fast high-mobility motion system adapted for tele-operation in plain indoor areas, which incorporates a high-priority collision avoidance procedure. This paper presents the mechanical architecture, electrical fundaments and software implementation required in order to develop the main functionalities of an assistive robot. The APR uses a tablet in order to implement the basic peer-to-peer videoconference and tele-operation control combined with a tactile graphic user interface. The paper also presents the development of some applications proposed in the framework of an assisted living robot. PMID:27136552

  12. La Greffe de Peau dans le Traitement des Sequelles de la Main Brulee. A Propos de 152 Cas - Experience du Service de Chirurgie Plastique du Centre Hospitalier Universitaire Ibn-Sina, Rabat, Maroc

    PubMed Central

    El Mazouz, S.; Fejjal, N.; Hafidi, J.; Cherkab, L.; Mejjati, H.; Belfqih, R.; Gharib, N.; Abbassi, A.

    2010-01-01

    Summary La main est fréquemment exposée aux brûlures, entraînant des séquelles esthétiques et fonctionnelles. Le traitement de ces séquelles est surtout chirurgical et consiste en la greffe de peau, dont le type dépend de la localisation de la brûlure et du type des séquelles. Dans ce travail rétrospectif, nous rapportons une série de 152 cas de brûlures des mains colligés au service de chirurgie plastique du Centre Hospitalier Universitaire Ibn-Sina de Rabat sur une période de dix ans, allant de 1998 à 2007. Les indications thérapeutiques dépendent du type de séquelles et de la localisation de la brûlure. En tout, 97 patients ont bénéficié d'une greffe cutanée, dont 76% par greffe de peau totale, 21% par greffe de peau demi-épaisse et 3% par peau fine. Les séquelles des brûlures des mains posent un problème thérapeutique majeur, malgré la diversité des procédés chirurgicaux, d'où l'intérêt de la prévention. PMID:21991196

  13. Torsion d'annexe après hystérectomie abdominale: une première observation

    PubMed Central

    Elhjouji, Abderrahman; Zahdi, Othman; Baba, Hicham; Belhamidi, Said; Bounaim, Ahmed; Aitali, Abdelmounaim; Sair, Khalid

    2015-01-01

    La torsion d'annexes survient classiquement sur ovaires kystiques ou tumoraux. De rares cas de torsion ont été rapports dans la littérature après hystérectomie laparoscopique. Nous rapportons la première observation de torsion d'annexe survenant sur annexe normale après hystérectomie abdominale et décrivons les particularités de cette forme clinique. PMID:26759694

  14. Experimental study on the operational and the cooling performance of the APR+ passive auxiliary feedwater system

    SciTech Connect

    Kang, K. H.; Bae, B. U.; Kim, S.; Cho, Y. J.; Park, Y. S.; Kim, B. D.

    2012-07-01

    The passive auxiliary feedwater system (PAFS) is one of the advanced safety features adopted in the APR+ which is intended to completely replace the conventional active auxiliary feedwater system. The PAFS cools down the steam generator secondary side and eventually removes the decay heat from the reactor core by introducing a natural driving force mechanism; i.e., condensing steam in nearly-horizontal U-tubes submerged inside the passive condensation cooling tank (PCCT). With an aim of validating the cooling and operational performance of the PAFS, the separate effect test, PASCAL (PAFS Condensing Heat Removal Assessment Loop), is being performed to experimentally investigate the condensation heat transfer and natural convection phenomena in the PAFS. A single nearly-horizontal U-tube whose dimension is same as the prototypic U-tube of the APR+ PAFS is simulated in the PASCAL test. By performing the PASCAL test, the major thermal-hydraulic parameters such as local/overall heat transfer coefficients, fluid temperature inside the tube, wall temperature of the tube, and pool temperature distribution in the PCCT were produced not only to evaluate the current condensation heat transfer model but also to present database for the safety analysis related with the PAFS. (authors)

  15. Detection of the apr gene in proteolytic psychrotrophic bacteria isolated from refrigerated raw milk.

    PubMed

    Martins, Maurilio L; de Araújo, Elza F; Mantovani, Hilário C; Moraes, Célia A; Vanetti, Maria C D

    2005-07-15

    Bacteria of the genus Pseudomonas have been associated with the spoilage of raw milk and dairy products due to the production of thermostable proteolytic enzymes. The apr gene encodes for alkaline metalloprotease in Pseudomonas and other related bacteria. Its presence in psychrotrophic proteolytic bacteria isolated from raw milk collected from cooling tanks was verified. A polymerase chain reaction (PCR) technique was used with degenerate primers. Total DNA from 112 isolates was pooled in different groups and then used as template for the amplification reactions. Controls consisted of DNA extracted from 26 cultures. An expected DNA fragment of 194 bp was detected in groups that contained bacteria identified as Pseudomonas. The PCR product was observed only when DNA from control cultures of Pseudomonas aeruginosa, Pseudomonas fluorescens, Serratia marcescens and Aeromonas hydrophila were used. A detection limit assay indicated that the apr gene could be directly amplified from pasteurized milk inoculated with 10(8) CFU/ml of P. fluorescens. With this method it was possible to detect proteolytic bacteria at 10(5) CFU/ml in reconstituted skim milk powder if cells were recovered for DNA extraction before amplification. PMID:15992619

  16. Crystallization of the C-terminal redox domain of the sulfur-assimilatory enzyme APR1 from Arabidopsis thaliana

    PubMed Central

    Chen, Fang-Fang; Chang, Yu-Yung; Cho, Chao-Cheng; Hsu, Chun-Hua

    2014-01-01

    Plant-type APS reductase (APR), which catalyzes the reduction of activated sulfate to sulfite in plants, consists of a reductase domain and a C-terminal redox domain showing sequence homology to thioredoxin but possessing the activity of glutaredoxin. In order to understand the structural and biochemical properties of the redox domain of plant-type APS reductase, the C-terminal domain of APR1 (APR1C) from Arabidopsis thaliana was crystallized using the sitting-drop vapour-diffusion method. X-ray diffraction data were collected to a resolution of 2.70 Å on the SPXF beamline BL13B1 at the NSRRC, Taiwan. The crystals belonged to space group P43212 or P41212, with unit-cell parameters a = b = 58.2, c = 86.7 Å. With one molecule per asymmetric unit, the crystal volume per unit protein weight (V M) is 2.64 Å3 Da−1, which corresponds to a solvent content of approximately 53.49%. Further structure-based functional studies of APR1C would extend knowledge of the molecular mechanism and regulation of APR. PMID:25195893

  17. Après-Coup in French Psychoanalysis: The Long Afterlife of Nachträglichkeit: The First Hundred Years, 1893 to 1993.

    PubMed

    House, Jonathan; Slotnick, Julie

    2015-10-01

    Après-coup finds its origins in Freud's earliest psychoanalytic writings, but it was only half a century ago that French psychoanalysts rediscovered, clarified, and developed the concept and so brought it recognition as an essential Freudian concept. Because the history of après-coup is embedded in the French reading of Freud, this article will give an account of that reading in relation to après-coup. PMID:26485487

  18. Phylogenetic Diversity of aprA Genes in Subseafloor Sediments on the Northwestern Pacific Margin off Japan.

    PubMed

    Aoki, Masataka; Kakiuchi, Ryota; Yamaguchi, Takashi; Takai, Ken; Inagaki, Fumio; Imachi, Hiroyuki

    2015-01-01

    Markedly diverse sequences of the adenosine-5'-phosphosulfate reductase alpha subunit gene (aprA), which encodes a key enzyme in microbial sulfate reduction and sulfur oxidation, were detected in subseafloor sediments on the northwestern Pacific off Japan. The aprA gene sequences were grouped into 135 operational taxonomic units (90% sequence identity), including genes related to putative sulfur-oxidizing bacteria predominantly detected in sulfate-depleted deep sediments. Our results suggest that microbial ecosystems in the subseafloor biosphere have phylogenetically diverse genetic potentials to mediate cryptic sulfur cycles in sediments, even where sulfate is rarely present. PMID:26156553

  19. New tools for NTD vaccines: A case study of quality control assays for product development of the human hookworm vaccine Na-APR-1M74.

    PubMed

    Pearson, Mark S; Jariwala, Amar R; Abbenante, Giovanni; Plieskatt, Jordan; Wilson, David; Bottazzi, Maria Elena; Hotez, Peter J; Keegan, Brian; Bethony, Jeffrey M; Loukas, Alex

    2015-01-01

    Na-APR-1(M74) is an aspartic protease that is rendered enzymatically inactive by site-directed mutagenesis and is a candidate antigen component in the Human Hookworm Vaccine. The mutant protease exerts vaccine efficacy by inducing antibodies that neutralize the enzymatic activity of wild type enzyme (Na-APR-1wt) in the gut of the hookworm, thereby depriving the worm of its ability to digest its blood meal. Previously, canines immunized with Na-APR-1(M74) and challenged with Ancylostoma caninum were partially protected against hookworm challenge infection, especially from the loss in hemoglobin observed in control canines and canine immunoglobulin (Ig) G raised against Na-APR-1 was shown to inhibit the enzymatic activity of Na-APR-1 wt in vitro, thereby providing proof of concept of Na-APR-1(M74) as a vaccine antigen. The mutated version, Na-APR-1(M74), was then expressed at the cGMP level using a Nicotiana benthamiana expression system (Fraunhofer, CMB, Delaware, MD), formulated with Alhydrogel®, and used to immunize mice in a dose-ranging study to explore the enzyme-neutralizing capacity of the resulting anti- Na-APR-1(M74) IgG. As little as 0.99 μg of recombinant Na-APR-1(M74) could induce anti Na-APR-1(M74) IgG in mice that were capable of inhibiting Na-APR-1w t-mediated digestion of a peptide substrate by 89%. In the absence of enzymatic activity of Na-APR-1(M74) as a surrogate marker of protein functionality, we developed an assay based on the binding of a quenched fluorescence-labeled inhibitor of aspartic proteases, BODIPY-FL pepstatin A (BDP). Binding of BDP in the active site of Na-APR-1 wt was demonstrated by inhibition of enzymatic activity, and competitive binding with unlabelled pepstatin A. BDP also bound to Na-APR-1(M74) which was assessed by fluorescence polarization, but with an ∼ 50-fold reduction in the dissociation constant. Taken together, these assays comprise a "toolbox" that could be useful for the analyses of Na-APR-1(M74) as it

  20. Résultats fonctionnels de la chirurgie de la cataracte par phacoalternative avec implantation en chambre postérieure: à propos de 300 cas à Bobo Dioulasso (Burkina Faso)

    PubMed Central

    Diallo, Jean Wenceslas; Meda, Nonfounikoun; Ahnoux-Zabsonre, Ahgbatouhabéba; Yameogo, Claudette; Dolo, Mariam; Sanou, Jérôme; Daboue, Arsène

    2015-01-01

    La cataracte est la première cause de cécité curable dans le monde. Son traitement est chirurgical. Le but de notre travail a été d’évaluer les résultats de la phacoalternative ou la chirurgie de la cataracte à petite incision. Il s'est agi d'une étude transversale descriptive à collecte prospective allant du 1er janvier au 31 septembre 2014, chez des patients âgés d'au moins 40 ans. Les données socio-démographiques, l'acuité visuelle, l'astigmatisme et les complications ont été évalués. Nous avons inclus 300 yeux de 286 patients. L’âge moyen était de 66 ans (écart type 9,93) avec une prédominance masculine de 57,7%. Les co-morbidités étaient dominées par l'hypertension artérielle 30,33% des cas. L'acuité visuelle pré-opératoire était de moins de 1/20è dans 70, 7% des cas. En biométrie, la puissance moyenne était de 21,50 dioptries. L'implant posé a été adéquat dans 60%. Les principales complications per-opératoires étaient le chémosis post-anesthésie 4,67% et l'issue de vitrée moins de 2% des cas. Les complications post opératoires précoces ont été dominées par l’œdème de cornée 26,33%, et les complications tardives par la cataracte secondaire. L'astigmatisme induit était de 1, 12 dioptrie en moyenne (écart type 1,26). Sans correction, les résultats visuels étaient mauvais dans moins de 1%, limites dans 31%, et bons 68% suivants les normes de l'Organisation Mondiale de la Santé. La phacoalternative donne des résultats satisfaisants, avec peu de complications. L'amélioration du plateau technique et la disponibilité d'implants adéquats pourraient les améliorer. PMID:26140073

  1. Prenatal transportation alters the acute phase response (APR) of bull calves exposed to a lipopolysaccharide (LPS) challenge

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This study was designed to determine if prenatal transportation influences the acute phase response (APR) to a postnatal Lipopolysaccharide (LPS) challenge. Pregnant Brahman cows (n=96) matched by age and parity were separated into transported (TRANS; n=48; transported for 2 hours on gestational day...

  2. Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy

    PubMed Central

    Bykov, Vladimir J. N.; Zhang, Qiang; Zhang, Meiqiongzi; Ceder, Sophia; Abrahmsen, Lars; Wiman, Klas G.

    2016-01-01

    TP53 is the most frequently mutated gene in cancer. The p53 protein activates transcription of genes that promote cell cycle arrest or apoptosis, or regulate cell metabolism, and other processes. Missense mutations in TP53 abolish specific DNA binding of p53 and allow evasion of apoptosis and accelerated tumor progression. Mutant p53 often accumulates at high levels in tumor cells. Pharmacological reactivation of mutant p53 has emerged as a promising strategy for improved cancer therapy. Small molecules that restore wild type activity of mutant p53 have been identified using various approaches. One of these molecules, APR-246, is a prodrug that is converted to the Michael acceptor methylene quinuclidinone (MQ) that binds covalently to cysteines in p53, leading to refolding and restoration of wild type p53 function. MQ also targets the cellular redox balance by inhibiting thioredoxin reductase (TrxR1) and depleting glutathione. This dual mechanism of action may account for the striking synergy between APR-246 and platinum compounds. APR-246 is the only mutant p53-targeting compound in clinical development. A phase I/IIa clinical trial in hematological malignancies and prostate cancer showed good safety profile and clinical effects in some patients. APR-246 is currently tested in a phase Ib/II trial in patients with high-grade serous ovarian cancer. PMID:26870698

  3. The Experience of Staging Nijinsky's "L'Apres-Midi d'un Faune" in a Higher Education Dance Program

    ERIC Educational Resources Information Center

    Curran, Tina

    2010-01-01

    This study documented the experiences of staging Vaslav Nijinsky's "L'Apres-midi d'un Faune" in a higher education dance program. The ballet was staged from Labanotation. Research questions focused on teaching and learning pedagogy, characterization of the process over time, experiences of the participants and teaching approaches. The project…

  4. Validating the AP[R] German Language Exam through a Curricular Survey of Third-Year College Language Courses

    ERIC Educational Resources Information Center

    Bischof, Deborah Lokai

    2005-01-01

    Curriculum surveys are used periodically to validate the use of Advanced Place Program[R] (AP[R]) Exams as assessments of skills required for advanced college-level study. In the case of AP German Language, the target level is third-year college language study. This article presents results from a 2003 curriculum survey completed by third-year…

  5. Modeling of melt retention in EU-APR1400 ex-vessel core catcher

    SciTech Connect

    Granovsky, V. S.; Sulatsky, A. A.; Khabensky, V. B.; Sulatskaya, M. B.; Gusarov, V. V.; Almyashev, V. I.; Komlev, A. A.; Bechta, S.; Kim, Y. S.; Park, R. J.; Kim, H. Y.; Song, J. H.

    2012-07-01

    A core catcher is adopted in the EU-APR1400 reactor design for management and mitigation of severe accidents with reactor core melting. The core catcher concept incorporates a number of engineering solutions used in the catcher designs of European EPR and Russian WER-1000 reactors, such as thin-layer corium spreading for better cooling, retention of the melt in a water-cooled steel vessel, and use of sacrificial material (SM) to control the melt properties. SM is one of the key elements of the catcher design and its performance is critical for melt retention efficiency. This SM consists of oxide components, but the core catcher also includes sacrificial steel which reacts with the metal melt of the molten corium to reduce its temperature. The paper describes the required properties of SM. The melt retention capability of the core catcher can be confirmed by modeling the heat fluxes to the catcher vessel to show that it will not fail. The fulfillment of this requirement is demonstrated on the example of LBLOCA severe accident. Thermal and physicochemical interactions between the oxide and metal melts, interactions of the melts with SM, sacrificial steel and vessel, core catcher external cooling by water and release of non-condensable gases are modeled. (authors)

  6. General relativistic magnetohydrodynamic simulations of binary neutron star mergers with the APR4 equation of state

    NASA Astrophysics Data System (ADS)

    Endrizzi, A.; Ciolfi, R.; Giacomazzo, B.; Kastaun, W.; Kawamura, T.

    2016-08-01

    We present new results of fully general relativistic magnetohydrodynamic simulations of binary neutron star (BNS) mergers performed with the Whisky code. All the models use a piecewise polytropic approximation of the APR4 equation of state for cold matter, together with a ‘hybrid’ part to incorporate thermal effects during the evolution. We consider both equal and unequal-mass models, with total masses such that either a supramassive NS or a black hole is formed after merger. Each model is evolved with and without a magnetic field initially confined to the stellar interior. We present the different gravitational wave (GW) signals as well as a detailed description of the matter dynamics (magnetic field evolution, ejected mass, post-merger remnant/disk properties). Our simulations provide new insights into BNS mergers, the associated GW emission and the possible connection with the engine of short gamma-ray bursts (both in the ‘standard’ and in the ‘time-reversal’ scenarios) and other electromagnetic counterparts.

  7. Cas rare de rupture bilatérale des tendons d'Achille sans notion de tendinopathie ou de chirurgie de la cheville chez un jeune sportif: à propos d'un cas et revue de la literature

    PubMed Central

    Belmoubarik, Amine; Abouchane, Merouane; Mahraoui, Mohamed Amine

    2015-01-01

    Les lésions du tendon d'Achille sont plus fréquentes que celles du tendon quadricipital ou patellaire. Les lésions bilatérales sont par contre plus rares et sont souvent associées à une notion de tendinopathie, d'injection de corticoïdes ou de maladies systémiques tels que le lupus érythémateux, l'ostéomalacie ou l'insuffisance rénale chronique. Nous rapportons le cas d'un patient de 34 ans victime d'une rupture bilatérale des tendons d'Achille suite à une réception de saut lors de la pratique de gymnastique. Le patient n’était pas suivi pour maladie de système ou mis sous corticothérapie ou fluoroquinolones. Le diagnostic a été suspecté devant une dépression anormalement creusant le relief sous cutané des deux tendons d'Achille avec une impossibilité de flexion dorsale des deux chevilles en association à un signe de Thompson bilatéralement positif. L’échographie a confirmé le diagnostic. Le patient a été traité par laçage et suture tendineuse à ciel ouvert. La rupture bilatérale du tendon d'Achille est rare. La plupart des patients rapportent une notion de maladie systémique ou un antécédent de chirurgie du genou. Nous rapportons le cas d'une lésion rare dans la littérature, une rupture bilatérale des tendons achiléens sans notions de maladies auto-immunes ni de traitement aux corticoïdes. Les lésions bilatérales présentent certaines particularités thérapeutiques et évolutives. En effet, deux difficultés sont à noter la première réside dans l'absence de référence comparative pour régler et apprécier l’équin physiologique lors de la réparation tendineuse. La deuxième difficulté est l'obligation de différer l'appui à 45 jours. Ce qui est contraignant pour le patient. La technique de réparation à ciel ouvert couplée à une immobilisation en équin protégeant la suture nous a donné des résultats satisfaisants. PMID:26140066

  8. Single port-assisted fully laparoscopic abdominoperineal resection (APR) with immediate V-RAM flap reconstruction of the perineal defect.

    PubMed

    Ali, Sayid; Moftah, Mohamed; Ajmal, Nadeem; Cahill, Ronan A

    2012-09-01

    Abdominoperineal resection (APR) of anorectal cancers after neoadjuvant chemoradiotherapy may incur significant perineal morbidity. While vertical rectus abdominis muscle (V-RAM) flaps can fill the pelvic resection space with health tissue, their use has previously been described predominantly in association with laparotomy. Here, we describe a means of combination laparoscopic APR with V-RAM flap reconstruction that allows structural preservation of the entire abdominal wall throughout the oncological resection and of the deep parietal layers after V-RAM donation. Furthermore, a single port access device used at the end colostomy site allows a second senior surgeon assist with an additional two working instruments for the purpose of improved pelvic tissue retraction, especially useful in obese patients. PMID:22644717

  9. Anti-Influenza Activity of Betulinic Acid from Zizyphus jujuba on Influenza A/PR/8 Virus

    PubMed Central

    Hong, Eun-Hye; Song, Jae Hyoung; Kang, Kyo Bin; Sung, Sang Hyun; Ko, Hyun-Jeong; Yang, Heejung

    2015-01-01

    Betulinic acid, a pentacyclic triterpene isolated from Jujube tree (Zizyphus jujuba Mill), has been known for a wide range of biological and medicinal properties such as antibacterial, antimalarial, anti-inflammatory, antihelmintic, antinociceptive, and anticancer activities. In the study, we investigated the antiviral activity on influenza A/PR/8 virus infected A549 human lung adenocarcinoma epithelial cell line and C57BL/6 mice. Betulinic acid showed the anti-influenza viral activity at a concentration of 50 μM without a significant cytotoxicity in influenza A/PR/8 virus infected A549 cells. Also, betulinic acid significantly attenuated pulmonary pathology including increased necrosis, numbers of inflammatory cells and pulmonary edema induced by influenza A/PR/8 virus infection compared with vehicle- or oseltamivir-treated mice in vivo model. The down-regulation of IFN-γ level, which is critical for innate and adaptive immunity in viral infection, after treating of betulinic acid in mouse lung. Based on the obtained results, it is suggested that betulinic acid can be the potential therapeutic agent for virus infection via anti-inflammatory activity. PMID:26157551

  10. Facteurs déterminants le regret après ligature tubaire

    PubMed Central

    Boufettal, Houssine; Mahdaoui, Sakher; Samouh, Naïma

    2014-01-01

    Introduction La ligature tubaire peut générer regret. Le but de cette étude est d’étudier le vécu après la stérilisation ainsi que le regret et ses facteurs de risque. Méthodes Il s'agit d'une étude rétrospective chez 52 femmes stérilisées entre 2004 et 2010. Résultats Vingt cinq (48%) femmes avaient regretté la réalisation de la ligature tubaire. La moyenne d’âge était de 40,5 ans. Le temps consacré aux explications était très court dans tous les cas. Trois quart des femmes n’était pas au courant des complications de la ligature tubaire. Le regret était dû au facteur religieux (23%), aux algies pelviennes (11,5%), au désir d'autres enfants (9,6%) ou à la prise de connaissance d'autres moyens contraceptifs (3,9%). Conclusion Un certains nombre de facteurs de risque de regret de la ligature tubaire sont retrouvés dans la littérature, comme dans notre série, dont l’âge, le désir de procréer, l'information incomplète, le délai de réflexion et le facteur religieux. PMID:25309644

  11. Apres ORIENT, a PT-based new resource strategy in nuclear fuel cycle

    SciTech Connect

    Ozawa, M.; Han, C.Y.; Kaneshiki, T.; Nilsson, M.

    2013-07-01

    The 'Apres ORIENT' research program, recently initiated in 2011, will deal with the transmutation of radioactive fission products (FP) to create rare metals / rare earth (RE) elements (NRM) by neutron capture on the FP followed by beta- decay. Target are radioactive FP and any created NRM should be more valuable and non-, or significantly less, radioactive than the initial FP. In the case of transmutation of radioactive Ba (i.e., non RE element) to La (i.e., light RE), the yield of {sup 139}La was low (< 3.5 %) with 5 years irradiation at thermal neutron energy conditions. However, by neutron irradiation in the fast reactor blanket region corresponding to a resonance energy range of 10 - 100 keV with an expected cross section, σ{sub γ}=0.27 b, of {sup 139}Ba a higher transmutation rate of more than 12 % over 5 years is obtained when the neutron flux is 1.0*10{sup 15} n/cm{sup 2}*s. Created La will be non-radioactive (< 0.001 Bq/g) despite natural La is slightly radioactive ca. 1 Bq/g. To facilitate Ba/La separation various kinds of crown ether (CE) resins were tested. The highest separation of Ba{sup 2+}/La{sup 3+} was obtained by a newly synthesized Benzo-18-Crown-6 (BC18) -substituted resin indicating SF(Ba/La) > 1,000 at 5 mol/l HCl medium. To confirm the scientific feasibility on such new program, actual irradiation tests by various target materials in a test reactor and separation/analysis of the products are required. While the test reactor available at the University of California Irvine has a steady state flux in the order of 10{sup 12} n/cm{sup 2}*s which is at least 2 orders of magnitude lower than a conventional power reactor, proof-of-concept investigations will be carried out since the production of nuclides should scale up linearly with the neutron flux. (author)

  12. Processing of High Resolution, Multiparametric Radar Data for the Airborne Dual-Frequency Precipitation Radar APR-2

    NASA Technical Reports Server (NTRS)

    Tanelli, Simone; Meagher, Jonathan P.; Durden, Stephen L.; Im, Eastwood

    2004-01-01

    Following the successful Precipitation Radar (PR) of the Tropical Rainfall Measuring Mission, a new airborne, 14/35 GHz rain profiling radar, known as Airborne Precipitation Radar - 2 (APR-2), has been developed as a prototype for an advanced, dual-frequency spaceborne radar for a future spaceborne precipitation measurement mission. . This airborne instrument is capable of making simultaneous measurements of rainfall parameters, including co-pol and cross-pol rain reflectivities and vertical Doppler velocities, at 14 and 35 GHz. furthermore, it also features several advanced technologies for performance improvement, including real-time data processing, low-sidelobe dual-frequency pulse compression, and dual-frequency scanning antenna. Since August 2001, APR-2 has been deployed on the NASA P3 and DC8 aircrafts in four experiments including CAMEX-4 and the Wakasa Bay Experiment. Raw radar data are first processed to obtain reflectivity, LDR (linear depolarization ratio), and Doppler velocity measurements. The dataset is then processed iteratively to accurately estimate the true aircraft navigation parameters and to classify the surface return. These intermediate products are then used to refine reflectivity and LDR calibrations (by analyzing clear air ocean surface returns), and to correct Doppler measurements for the aircraft motion. Finally, the the melting layer of precipitation is detected and its boundaries and characteristics are identifIed at the APR-2 range resolution of 30m. The resulting 3D dataset will be used for validation of other airborne and spaceborne instruments, development of multiparametric rain/snow retrieval algorithms and melting layer characterization and statistics.

  13. Multi-analytical characterisation of D'Aprés Cormon by José Veloso Salgado

    NASA Astrophysics Data System (ADS)

    Cardeira, A. M.; Longelin, S.; Costa, S.; Candeias, A.; Carvalho, M. L.; Manso, M.

    2014-07-01

    This case study reveals the analytical characterisation carried out on ‘D'Aprés Cormon' (1891) by Veloso Salgado, a copy of ‘Caïn' (1880) by Fernando Cormon, belonging nowadays to Musée d'Orsay. Infrared Reflectography made in situ revealed underdrawing grid that was used to transpose the original painting to a smaller scale, pictorial style, execution method and retouched/restored areas. In situ EDXRF analysis together with Raman microscopy allowed the identification of gypsum, lead white, titanium white, yellow ochre, vermilion, ultramarine and lamp black. These results provide valuable information about the Salgado's palette and his production technique.

  14. A Bayesian inversion for slip distribution of 1 Apr 2007 Mw8.1 Solomon Islands Earthquake

    NASA Astrophysics Data System (ADS)

    Chen, T.; Luo, H.

    2013-12-01

    On 1 Apr 2007 the megathrust Mw8.1 Solomon Islands earthquake occurred in the southeast pacific along the New Britain subduction zone. 102 vertical displacement measurements over the southeastern end of the rupture zone from two field surveys after this event provide a unique constraint for slip distribution inversion. In conventional inversion method (such as bounded variable least squares) the smoothing parameter that determines the relative weight placed on fitting the data versus smoothing the slip distribution is often subjectively selected at the bend of the trade-off curve. Here a fully probabilistic inversion method[Fukuda,2008] is applied to estimate distributed slip and smoothing parameter objectively. The joint posterior probability density function of distributed slip and the smoothing parameter is formulated under a Bayesian framework and sampled with Markov chain Monte Carlo method. We estimate the spatial distribution of dip slip associated with the 1 Apr 2007 Solomon Islands earthquake with this method. Early results show a shallower dip angle than previous study and highly variable dip slip both along-strike and down-dip.

  15. [Preparation and Identification of High Immunogenic A/PR/8/34 Maternal Strain HA Protein for Influenza Virus Classical Reassortment].

    PubMed

    Tang, Jing; Xin, Li; Guo, Junfeng; Zhu, Wenfei; Zhang, Heyuan; Lang, Shaohui; Wang, Dayan; Shu, Yuelong

    2016-03-01

    Preparation of maternal strain A/PR/8/34 HA antiserum for influenza virus classical reassortment. A/PR/8/34 virus was digested by bromelain after inactivation and purification. 5%-20% sucrose continuous density gradient centrifugation method was used to purify HA protein. SIRD method was used to select the target protein. SDS-PAGE method was used to identified HA protein. High Immunogenic A/PR/8/34 HA protein was successfully prepared and HI titer reached 10240. High purity HA antiserum was identified by SIRD method. The key reagent in the classical reassortment of influenza virus was prepared, and the complete set of technical methods were explored, which laid the foundation for the independent research and development of seasonal influenza vaccine strains of China. PMID:27396155

  16. Sulphur flux through the sulphate assimilation pathway is differently controlled by adenosine 5′-phosphosulphate reductase under stress and in transgenic poplar plants overexpressing γ-ECS, SO, or APR

    PubMed Central

    Scheerer, Ursula; Haensch, Robert; Mendel, Ralf R.; Kopriva, Stanislav; Rennenberg, Heinz; Herschbach, Cornelia

    2010-01-01

    Sulphate assimilation provides reduced sulphur for the synthesis of cysteine, methionine, and numerous other essential metabolites and secondary compounds. The key step in the pathway is the reduction of activated sulphate, adenosine 5′-phosphosulphate (APS), to sulphite catalysed by APS reductase (APR). In the present study, [35S]sulphur flux from external sulphate into glutathione (GSH) and proteins was analysed to check whether APR controls the flux through the sulphate assimilation pathway in poplar roots under some stress conditions and in transgenic poplars. (i) O-Acetylserine (OAS) induced APR activity and the sulphur flux into GSH. (ii) The herbicide Acetochlor induced APR activity and results in a decline of GSH. Thereby the sulphur flux into GSH or protein remained unaffected. (iii) Cd treatment increased APR activity without any changes in sulphur flux but lowered sulphate uptake. Several transgenic poplar plants that were manipulated in sulphur metabolism were also analysed. (i) Transgenic poplar plants that overexpressed the γ-glutamylcysteine synthetase (γ-ECS) gene, the enzyme catalysing the key step in GSH formation, showed an increase in sulphur flux into GSH and sulphate uptake when γ-ECS was targeted to the cytosol, while no changes in sulphur flux were observed when γ-ECS was targeted to plastids. (ii) No effect on sulphur flux was observed when the sulphite oxidase (SO) gene from Arabidopsis thaliana, which catalyses the back reaction of APR, that is the reaction from sulphite to sulphate, was overexpressed. (iii) When Lemna minor APR was overexpressed in poplar, APR activity increased as expected, but no changes in sulphur flux were observed. For all of these experiments the flux control coefficient for APR was calculated. APR as a controlling step in sulphate assimilation seems obvious under OAS treatment, in γ-ECS and SO overexpressing poplars. A possible loss of control under certain conditions, that is Cd treatment, Acetochlor

  17. Sulphur flux through the sulphate assimilation pathway is differently controlled by adenosine 5'-phosphosulphate reductase under stress and in transgenic poplar plants overexpressing gamma-ECS, SO, or APR.

    PubMed

    Scheerer, Ursula; Haensch, Robert; Mendel, Ralf R; Kopriva, Stanislav; Rennenberg, Heinz; Herschbach, Cornelia

    2010-01-01

    Sulphate assimilation provides reduced sulphur for the synthesis of cysteine, methionine, and numerous other essential metabolites and secondary compounds. The key step in the pathway is the reduction of activated sulphate, adenosine 5'-phosphosulphate (APS), to sulphite catalysed by APS reductase (APR). In the present study, [(35)S]sulphur flux from external sulphate into glutathione (GSH) and proteins was analysed to check whether APR controls the flux through the sulphate assimilation pathway in poplar roots under some stress conditions and in transgenic poplars. (i) O-Acetylserine (OAS) induced APR activity and the sulphur flux into GSH. (ii) The herbicide Acetochlor induced APR activity and results in a decline of GSH. Thereby the sulphur flux into GSH or protein remained unaffected. (iii) Cd treatment increased APR activity without any changes in sulphur flux but lowered sulphate uptake. Several transgenic poplar plants that were manipulated in sulphur metabolism were also analysed. (i) Transgenic poplar plants that overexpressed the gamma-glutamylcysteine synthetase (gamma-ECS) gene, the enzyme catalysing the key step in GSH formation, showed an increase in sulphur flux into GSH and sulphate uptake when gamma-ECS was targeted to the cytosol, while no changes in sulphur flux were observed when gamma-ECS was targeted to plastids. (ii) No effect on sulphur flux was observed when the sulphite oxidase (SO) gene from Arabidopsis thaliana, which catalyses the back reaction of APR, that is the reaction from sulphite to sulphate, was overexpressed. (iii) When Lemna minor APR was overexpressed in poplar, APR activity increased as expected, but no changes in sulphur flux were observed. For all of these experiments the flux control coefficient for APR was calculated. APR as a controlling step in sulphate assimilation seems obvious under OAS treatment, in gamma-ECS and SO overexpressing poplars. A possible loss of control under certain conditions, that is Cd treatment

  18. Carcinoïde primitif du rein métastasant après 12 ans

    PubMed Central

    Bacha, Dhouha; Lahmar, Ahlem; Gharbi, Lassad; Slama, Sana Ben; Bouraoui, Saadia; Chatti, Samia; Regaya, Sabeh Mzabi

    2016-01-01

    Les carcinoïdes primitifs du rein sont rares avec une centaine de cas rapportés dans la littérature. Sur le plan histologique, il s'agit d'une tumeur bien différenciée dont la morphologie rejoint souvent celle des carcinoïdes dans les autres localisations. Nous rapportons un cas de carcinoïde primitif du rein survenant chez un homme de 41 ans, découvert à la suite de métastases hépatiques. La tumeur était particulière par son architecture tubulo-papillaire, suggérant à tort le diagnostic de carcinome papillaire du rein. Ce diagnostic a été redressé 12 ans après, à la suite de l'apparition d'autres métastases hépatiques, osseuses et pulmonaires. PMID:27217899

  19. Vascular endothelial growth factor concentrations in the plasma-activated platelets rich (P-APR) of healthy controls and colorectal cancer patients.

    PubMed

    Ranieri, Girolamo; Coviello, Maria; Patruno, Rosa; Valerio, Paolo; Martino, Domenico; Milella, Pietro; Catalano, Vittorio; Scotto, Francesco; De Ceglie, Antonella; Quaranta, Michele; Ribatti, Domenico; Pellecchia, Antonio

    2004-10-01

    Vascular endothelial growth factor (VEGF) is known to play a key role in tumour angiogenesis. Our preliminary published data suggest that plasma-activated platelets rich (P-APR) rather than other plasma compartments (i.e. plasma, plasma-platelets poor) or serum is the more suitable blood fraction for measuring VEGF in a miscellaneous series of gastrointestinal cancer patients. The aim of this confirmatory study was to assess VEGF in P-APR blood compartments of 30 healthy control subjects (HCS) and a homogeneous series of 62 colorectal cancer patients (CRCP), prospectively collected, to evaluate its possible clinical-biological significance. Samples of plasma (P) in both sodium citrate (SC) and sodium citrate-theophylline-adenosine-dipyridamole (CTAD) were collected from venous blood. After the centrifugation and separation methods VEGF levels were detected by ELISA in P-APR. The best differentiation between HCS and CRCP in VEGF level was seen for P-APRCTAD (median value: 255 pg/ml versus 142 pg/ml; p=0.000 by Mann-Whitney U test). No significant correlation among the P-APR VEGF concentrations and the main clinical pathological features was found. We suggest that P-APRCTAD fraction, obtained according to well standardised conditions, could represent the suitable blood compartment for the assessment of VEGF as marker of malignant intestinal transformation. PMID:15375505

  20. Synthesis of Key Points from the OSEP Early Childhood Transition FAQ (SPP/APR Indicators C-8, B-11 and B-12)

    ERIC Educational Resources Information Center

    Diefendorf, M.; Henson, J.; Lucas, A.; Whaley, K.

    2010-01-01

    This document is a synthesis of the key points provided in the Office of Special Education Programs (OSEP) Early Childhood Transition FAQs: SPP/APR indicators C-8 and B-12 released on December 1, 2009. It was developed to assist states with the implementation of effective transition policies and practices. The following is included: (1) Transition…

  1. Effect of surgical castration of bull calves at different stages of maturity with or without analgesia on the acute phase response (APR) and complete blood count (CBC)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The study objective was to determine if surgical castration at birth or weaning impacts the acute phase response (APR) or complete blood counts (CBC) and whether concurrent administration of an oral analgesic (meloxicam) ameliorates inflammation. Bull calves (n=29) from the University of Arkansas re...

  2. 15 CFR 781.4 - U.S. Government requests for information needed to satisfy the requirements of the APR or the Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false U.S. Government requests for information needed to satisfy the requirements of the APR or the Act. 781.4 Section 781.4 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND...

  3. 78 FR 14155 - Special Conditions: Learjet Inc., Model LJ-200-1A10 Airplane; Use of Automatic Power Reserve (APR...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-05

    ..., 2000 (65 FR 19477-19478), as well as at http://DocketsInfo.dot.gov/ . Docket: Background documents or... Power Reserve (APR), an Automatic Takeoff Thrust Control System (ATTCS), for Go-Around Performance... airplane will have novel or unusual design features associated with utilizing go-around performance...

  4. APR-246 (PRIMA-1(MET)) strongly synergizes with AZD2281 (olaparib) induced PARP inhibition to induce apoptosis in non-small cell lung cancer cell lines.

    PubMed

    Deben, Christophe; Lardon, Filip; Wouters, An; Op de Beeck, Ken; Van den Bossche, Jolien; Jacobs, Julie; Van Der Steen, Nele; Peeters, Marc; Rolfo, Christian; Deschoolmeester, Vanessa; Pauwels, Patrick

    2016-06-01

    APR-246 (PRIMA-1(Met)) is able to bind mutant p53 and restore its normal conformation and function. The compound has also been shown to increase intracellular ROS levels. Importantly, the poly-[ADP-ribose] polymerase-1 (PARP-1) enzyme plays an important role in the repair of ROS-induced DNA damage. We hypothesize that by blocking this repair with the PARP-inhibitor AZD2281 (olaparib), DNA damage would accumulate in the cell leading to massive apoptosis. We observed that APR-246 synergistically enhanced the cytotoxic response of olaparib in TP53 mutant non-small cell lung cancer cell lines, resulting in a strong apoptotic response. In the presence of wild type p53 a G2/M cell cycle block was predominantly observed. NOXA expression levels were significantly increased in a TP53 mutant background, and remained unchanged in the wild type cell line. The combined treatment of APR-246 and olaparib induced cell death that was associated with increased ROS production, accumulation of DNA damage and translocation of p53 to the mitochondria. Out data suggest a promising targeted combination strategy in which the response to olaparib is synergistically enhanced by the addition of APR-246, especially in a TP53 mutant background. PMID:26975633

  5. Le don après un décès d'origine cardiocirculatoire au Canada

    PubMed Central

    Shemie, Sam D.; Baker, Andrew J.; Knoll, Greg; Wall, William; Rocker, Graeme; Howes, Daniel; Davidson, Janet; Pagliarello, Joe; Chambers-Evans, Jane; Cockfield, Sandra; Farrell, Catherine; Glannon, Walter; Gourlay, William; Grant, David; Langevin, Stéphan; Wheelock, Brian; Young, Kimberly; Dossetor, John

    2006-01-01

    Résumé Ces recommandations sont le fruit d'un processus multidisciplinaire national ayant duré un an et visant à déterminer si et comment l'on pourrait procéder au don d'organes après un décès d'origine cardiocirculatoire («don après le décès cardiocirculatoire», ou DDC) au Canada. Le forum national organisé en février 2005 a permis aux participants de discuter et d'élaborer des recommandations sur les principes, interventions et pratiques se rapportant au DDC. Les aspects éthiques et juridiques ont été abordés dans les discussions. À la fin du Forum, la majorité des participants ont été favorables à l'implantation de programmes de DDC au Canada. Les participants du Forum ont également convenu qu'il fallait formuler et prôner des valeurs fondamentales pour orienter l'élaboration de programmes et de protocoles basés sur le cadre médical, éthique et juridique établi lors de cette réunion. Même si la possibilité d'un don d'organes et de tissus doit faire partie intégrante des soins de fin de vie, il faut insister sur le fait que le devoir de diligence envers les patients mourants et leurs familles doit demeurer la priorité des équipes soignantes. La complexité et les répercussions profondes du décès sont reconnues et doivent être respectées, de même que les différences personnelles, ethnoculturelles et religieuses face à la mort et au don d'organes. Les décisions d'arrêter le traitement de maintien des fonctions vitales, la prise en charge des derniers moments de la vie et le diagnostic de décès selon des critères cardiocirculatoires doivent être distincts et indépendants des processus de don et transplantation. Ce rapport contient des recommandations destinées aux gestionnaires de program, aux autorités sanitaires régionales et aux instances appelés à élaborer les protocoles de DDC. Les programmes doivent être conçus en fonction des éléments suivants : direction et planification locales, éducation et

  6. APR-246/PRIMA-1(MET) rescues epidermal differentiation in skin keratinocytes derived from EEC syndrome patients with p63 mutations.

    PubMed

    Shen, Jinfeng; van den Bogaard, Ellen H; Kouwenhoven, Evelyn N; Bykov, Vladimir J N; Rinne, Tuula; Zhang, Qiang; Tjabringa, Geuranne S; Gilissen, Christian; van Heeringen, Simon J; Schalkwijk, Joost; van Bokhoven, Hans; Wiman, Klas G; Zhou, Huiqing

    2013-02-01

    p53 and p63 share extensive sequence and structure homology. p53 is frequently mutated in cancer, whereas mutations in p63 cause developmental disorders manifested in ectodermal dysplasia, limb defects, and orofacial clefting. We have established primary adult skin keratinocytes from ectrodactyly, ectodermal dysplasia, and cleft lip/palate (EEC) syndrome patients with p63 mutations as an in vitro human model to study the disease mechanism in the skin of EEC patients. We show that these patient keratinocytes cultured either in submerged 2D cultures or in 3D skin equivalents have impaired epidermal differentiation and stratification. Treatment of these patient keratinocytes with the mutant p53-targeting compound APR-246/PRIMA-1(MET) (p53 reactivation and induction of massive apoptosis) that has been successfully tested in a phase I/II clinical trial in cancer patients partially but consistently rescued morphological features and gene expression during epidermal stratification in both 2D and 3D models. This rescue coincides with restoration of p63 target-gene expression. Our data show that EEC patient keratinocytes with p63 mutations can be used for characterization of the abnormal molecular circuitry in patient skin and may open possibilities for the design of novel pharmacological treatment strategies for patients with mutant p63-associated developmental abnormalities. PMID:23355676

  7. Experimental and code simulation of a station blackout scenario for APR1400 with test facility ATLAS and MARS code

    SciTech Connect

    Yu, X. G.; Kim, Y. S.; Choi, K. Y.; Park, H. S.; Cho, S.; Kang, K. H.; Choi, N. H.

    2012-07-01

    A SBO (station blackout) experiment named SBO-01 was performed at full-pressure IET (Integral Effect Test) facility ATLAS (Advanced Test Loop for Accident Simulation) which is scaled down from the APR1400 (Advanced Power Reactor 1400 MWe). In this study, the transient of SBO-01 is discussed and is subdivided into three phases: the SG fluid loss phase, the RCS fluid loss phase, and the core coolant depletion and core heatup phase. In addition, the typical phenomena in SBO-01 test - SG dryout, natural circulation, core coolant boiling, the PRZ full, core heat-up - are identified. Furthermore, the SBO-01 test is reproduced by the MARS code calculation with the ATLAS model which represents the ATLAS test facility. The experimental and calculated transients are then compared and discussed. The comparison reveals there was malfunction of equipments: the SG leakage through SG MSSV and the measurement error of loop flow meter. As the ATLAS model is validated against the experimental results, it can be further employed to investigate the other possible SBO scenarios and to study the scaling distortions in the ATLAS. (authors)

  8. Antiviral activity of the plant extracts from Thuja orientalis, Aster spathulifolius, and Pinus thunbergii against influenza virus A/PR/8/34.

    PubMed

    Won, Ji-Na; Lee, Seo-Yong; Song, Dae-sub; Poo, Haryoung

    2013-01-01

    Influenza viruses cause significant morbidity and mortality in humans through epidemics or pandemics. Currently, two classes of anti-influenza virus drugs, M2 ion-channel inhibitors (amantadin and rimantadine) and neuraminidase inhibitors (oseltamivir and zanamivir), have been used for the treatment of the influenza virus infection. Since the resistance to these drugs has been reported, the development of a new antiviral agent is necessary. In this study, we examined the antiviral efficacy of the plant extracts against the influenza A/PR/8/34 infection. In vitro, the antiviral activities of the plant extracts were investigated using the cell-based screening. Three plant extracts, Thuja orientalis, Aster spathulifolius, and Pinus thunbergii, were shown to induce a high cell viability rate after the infection with the influenza A/PR/8/34 virus. The antiviral activity of the plant extracts also increased as a function of the concentration of the extracts and these extracts significantly reduced the visible cytopathic effect caused by virus infections. Furthermore, the treatment with T. orientalis was shown to have a stronger inhibitory effect than that with A. spathulifolius or P. thunbergii. These results may suggest that T. orientalis has anti-influenza A/PR/8/34 activity. PMID:23314378

  9. Nighttime Near Infrared Observations of Augustine Volcano Jan-Apr, 2006 Recorded With a Small Astronomical CCD Camera

    NASA Astrophysics Data System (ADS)

    Sentman, D.; McNutt, S.; Reyes, C.; Stenbaek-Nielsen, H.; Deroin, N.

    2006-12-01

    Nighttime observations of Augustine Volcano were made during Jan-Apr, 2006 using a small, unfiltered, astronomical CCD camera operating from Homer, Alaska. Time-lapse images of the volcano were made looking across the open water of the Cook Inlet over a slant range of ~105 km. A variety of volcano activities were observed that originated in near-infrared (NIR) 0.9-1.1 micron emissions, which were detectable at the upper limit of the camera passband but were otherwise invisible to the naked eye. These activities included various types of steam releases, pyroclastic flows, rockfalls and debris flows that were correlated very closely with seismic measurements made from instruments located within 4 km on the volcanic island. Specifically, flow events to the east (towards the camera) produced high amplitudes on the eastern seismic stations and events presumably to the west were stronger on western stations. The ability to detect nighttime volcanic emissions in the NIR over large horizontal distances using standard silicon CCD technology, even in the presence of weak intervening fog, came as a surprise, and is due to a confluence of several mutually reinforcing factors: (1) Hot enough (~1000K) thermal emissions from the volcano that the short wavelength portion of the Planck radiation curve overlaps the upper portions (0.9-1.1 micron) of the sensitivity of the silicon CCD detectors, and could thus be detected, (2) The existence of several atmospheric transmission windows within the NIR passband of the camera for the emissions to propagate with relatively small attenuation through more than 10 atmospheres, and (3) in the case of fog, forward Mie scattering.

  10. p53 Reactivation by PRIMA-1(Met) (APR-246) sensitises (V600E/K)BRAF melanoma to vemurafenib.

    PubMed

    Krayem, Mohammad; Journe, Fabrice; Wiedig, Murielle; Morandini, Renato; Najem, Ahmad; Salès, François; van Kempen, Leon C; Sibille, Catherine; Awada, Ahmad; Marine, Jean-Christophe; Ghanem, Ghanem

    2016-03-01

    Intrinsic and acquired resistance of metastatic melanoma to (V600E/K)BRAF and/or MEK inhibitors, which is often caused by activation of the PI3K/AKT survival pathway, represents a major clinical challenge. Given that p53 is capable of antagonising PI3K/AKT activation we hypothesised that pharmacological restoration of p53 activity may increase the sensitivity of BRAF-mutant melanoma to MAPK-targeted therapy and eventually delay and/or prevent acquisition of drug resistance. To test this possibility we exposed a panel of vemurafenib-sensitive and resistant (innate and acquired) (V600E/K)BRAF melanomas to a (V600E/K)BRAF inhibitor (vemurafenib) alone or in combination with a direct p53 activator (PRIMA-1(Met)/APR-246). Strikingly, PRIMA-1(Met) synergised with vemurafenib to induce apoptosis and suppress proliferation of (V600E/K)BRAF melanoma cells in vitro and to inhibit tumour growth in vivo. Importantly, this drug combination decreased the viability of both vemurafenib-sensitive and resistant melanoma cells irrespectively of the TP53 status. Notably, p53 reactivation was invariably accompanied by PI3K/AKT pathway inhibition, the activity of which was found as a dominant resistance mechanism to BRAF inhibition in our lines. From all various combinatorial modalities tested, targeting the MAPK and PI3K signalling pathways through p53 reactivation or not, the PRIMA-1(Met)/vemurafenib combination was the most cytotoxic. We conclude that PRIMA-1(Met) through its ability to directly reactivate p53 regardless of the mechanism causing its deactivation, and thereby dampen PI3K signalling, sensitises (V600E/K)BRAF-positive melanoma to BRAF inhibitors. PMID:26790143

  11. Molecular Analysis of the Diversity of Sulfate-Reducing and Sulfur-Oxidizing Prokaryotes in the Environment, Using aprA as Functional Marker Gene▿ †

    PubMed Central

    Meyer, Birte; Kuever, Jan

    2007-01-01

    The dissimilatory adenosine-5′-phosposulfate reductase is a key enzyme of the microbial sulfate reduction and sulfur oxidation processes. Because the alpha- and beta-subunit-encoding genes, aprBA, are highly conserved among sulfate-reducing and sulfur-oxidizing prokaryotes, they are most suitable for molecular profiling of the microbial community structure of the sulfur cycle in environment. In this study, a new aprA gene-targeting assay using a combination of PCR and denaturing gradient gel electrophoresis is presented. The screening of sulfate-reducing and sulfur-oxidizing reference strains as well as the analyses of environmental DNA from diverse habitats (e.g., microbial mats, invertebrate tissue, marine and estuarine sediments, and filtered hydrothermal water) by the new primer pair revealed an improved microbial diversity coverage and less-pronounced template-to-PCR product bias in direct comparison to those of the previously published primer set (B. Deplancke, K. R. Hristova, H. A. Oakley, V. J. McCracken, R. Aminov, R. I. Mackie, and H. R. Gaskins, Appl. Environ. Microbiol. 66:2166-2174, 2000). The concomitant molecular detection of sulfate-reducing and sulfur-oxidizing prokaryotes was confirmed. The new assay was applied in comparison with the 16S rRNA gene-based analysis to investigate the microbial diversity of the sulfur cycle in sediment, seawater, and manganese crust samples from four study sites in the area of the Lesser Antilles volcanic arc, Caribbean Sea (Caribflux project). The aprA gene-based approach revealed putative sulfur-oxidizing Alphaproteobacteria of chemolithoheterotrophic lifestyle to have been abundant in the nonhydrothermal sediment and water column. In contrast, the sulfur-based microbial community that inhabited the surface of the volcanic manganese crust was more complex, consisting predominantly of putative chemolithoautotrophic sulfur oxidizers of the Betaproteobacteria and Gammaproteobacteria. PMID:17921272

  12. Peut-on réaliser une analgésie péridurale après un blood patch récent?

    PubMed Central

    Chkoura, Khalid; Kechna, Hicham; Loutid, Jaouad; Ouzad, Omar; Hachimi, Moulay Ahmed; Hannafi, Sidi Mohamed

    2015-01-01

    Le blood patch constitue le traitement de référence du syndrome post ponction lombaire. Son efficacité a été démontrée par plusieurs essais randomisés comparant le BPE aux mesures conservatrices et au placebo. Il consiste en l'injection d'une quantité de sang autologue dans l'espace péridurale afin d'obturer la brèche dure-mérienne. La réalisation d'une analgésie péridurale après antécédent de blood patch est possible, malgré la persistance de questions sur les délais de retour à la normal de l'espace péridurale. Nous rapportons un cas où une analgésie péridurale a été réalisée avec succès trois semaines après un blood patch. PMID:26600909

  13. Monoclinically distorted perovskites, A{sub 2}ZnTiO{sub 6} (A=Pr, Gd): Rietveld refinement, and dielectric studies

    SciTech Connect

    Das, Nibedita; Nath, Masood A.; Thakur, Gohil S.; Thirumal, M.; Ganguli, Ashok K.

    2015-09-15

    Double perovskite related oxide A{sub 2}ZnTiO{sub 6}A=Pr, Gd were synthesized by the solid state reaction method at 1523 K. The structure and microstructure of the compounds were studied by X-ray, SAED and FESEM. Rietveld refinement of the powder X-ray analysis shows that the compounds crystallizes in monoclinic space group P2{sub 1}/n (a{sup +}b{sup −}b{sup −}) with unit cell parameter √2a{sub p}×√2a{sub p}×2a{sub p} (a=5.5026(1) Å, b=5.6305(1) Å, c=7.8149(1) Å, β=90.02(1)° for Pr{sub 2}ZnTiO{sub 6} and a=5.3621(1) Å, b=5.6565(2) Å, c=7.6779(2) Å and β=90.264(2)° for Gd{sub 2}ZnTiO{sub 6}. Electron diffraction study confirms P2{sub 1}/n symmetry of the oxides. The monoclinic distortion is larger in Gd{sub 2}ZnTiO{sub 6} than Pr{sub 2}ZnTiO{sub 6} which is associated with the tolerance factor and the tilting angle of ZnO{sub 6} and TiO{sub 6} octahedra (ϕ=13.64° for Pr{sub 2}ZnTiO{sub 6} and 16.51° for Gd{sub 2}ZnTiO{sub 6}). The compounds are highly ordered. The charge and size difference between B site cations are the driving force for the ordering of the B′O{sub 6} and B″O{sub 6} octahedra. Pr{sub 2}ZnTiO{sub 6} shows a dielectric constant of 27 and dielectric loss of 0.003 while Gd{sub 2}ZnTiO{sub 6} has a dielectric constant of 17 and dielectric loss of 0.005 measured at 1 MHz. - Graphical abstract: Synthesis of new double perovskite dielectric material with very low dielectric loss. - Highlights: • Synthesis of new monoclinically distorted double perovskite (Pr{sub 2}ZnTiO{sub 6}). • Synthesis of monoclinically distorted double perovskite (Gd{sub 2}ZnTiO{sub 6}). • Selected area electron diffraction study of A{sub 2}ZnTiO{sub 6} (A=Pr, Gd). • Study of dielectric properties of A{sub 2}ZnTiO{sub 6} (A=Pr, Gd)

  14. Real-Time PCR Quantification and Diversity Analysis of the Functional Genes aprA and dsrA of Sulfate-Reducing Prokaryotes in Marine Sediments of the Peru Continental Margin and the Black Sea

    PubMed Central

    Blazejak, Anna; Schippers, Axel

    2011-01-01

    Sulfate-reducing prokaryotes (SRP) are ubiquitous and quantitatively important members in many ecosystems, especially in marine sediments. However their abundance and diversity in subsurface marine sediments is poorly understood. In this study, the abundance and diversity of the functional genes for the enzymes adenosine 5′-phosphosulfate reductase (aprA) and dissimilatory sulfite reductase (dsrA) of SRP in marine sediments of the Peru continental margin and the Black Sea were analyzed, including samples from the deep biosphere (ODP site 1227). For aprA quantification a Q-PCR assay was designed and evaluated. Depth profiles of the aprA and dsrA copy numbers were almost equal for all sites. Gene copy numbers decreased concomitantly with depth from around 108/g sediment close to the sediment surface to less than 105/g sediment at 5 mbsf. The 16S rRNA gene copy numbers of total bacteria were much higher than those of the functional genes at all sediment depths and used to calculate the proportion of SRP to the total Bacteria. The aprA and dsrA copy numbers comprised in average 0.5–1% of the 16S rRNA gene copy numbers of total bacteria in the sediments up to a depth of ca. 40 mbsf. In the zone without detectable sulfate in the pore water from about 40–121 mbsf (Peru margin ODP site 1227), only dsrA (but not aprA) was detected with copy numbers of less than 104/g sediment, comprising ca. 14% of the 16S rRNA gene copy numbers of total bacteria. In this zone, sulfate might be provided for SRP by anaerobic sulfide oxidation. Clone libraries of aprA showed that all isolated sequences originate from SRP showing a close relationship to aprA of characterized species or form a new cluster with only distant relation to aprA of isolated SRP. For dsrA a high diversity was detected, even up to 121 m sediment depth in the deep biosphere. PMID:22203820

  15. The LasB Elastase of Pseudomonas aeruginosa Acts in Concert with Alkaline Protease AprA To Prevent Flagellin-Mediated Immune Recognition

    PubMed Central

    Casilag, Fiordiligie; Lorenz, Anne; Krueger, Jonas; Klawonn, Frank; Weiss, Siegfried

    2015-01-01

    The opportunistic pathogen Pseudomonas aeruginosa is capable of establishing severe and persistent infections in various eukaryotic hosts. It encodes a wide array of virulence factors and employs several strategies to evade immune detection. In the present study, we screened the Harvard Medical School transposon mutant library of P. aeruginosa PA14 for bacterial factors that modulate interleukin-8 responses in A549 human airway epithelial cells. We found that in addition to the previously identified alkaline protease AprA, the elastase LasB is capable of degrading exogenous flagellin under calcium-replete conditions and prevents flagellin-mediated immune recognition. Our results indicate that the production of two proteases with anti-flagellin activity provides a failsafe mechanism for P. aeruginosa to ensure the maintenance of protease-dependent immune-modulating functions. PMID:26502908

  16. The LasB Elastase of Pseudomonas aeruginosa Acts in Concert with Alkaline Protease AprA To Prevent Flagellin-Mediated Immune Recognition.

    PubMed

    Casilag, Fiordiligie; Lorenz, Anne; Krueger, Jonas; Klawonn, Frank; Weiss, Siegfried; Häussler, Susanne

    2016-01-01

    The opportunistic pathogen Pseudomonas aeruginosa is capable of establishing severe and persistent infections in various eukaryotic hosts. It encodes a wide array of virulence factors and employs several strategies to evade immune detection. In the present study, we screened the Harvard Medical School transposon mutant library of P. aeruginosa PA14 for bacterial factors that modulate interleukin-8 responses in A549 human airway epithelial cells. We found that in addition to the previously identified alkaline protease AprA, the elastase LasB is capable of degrading exogenous flagellin under calcium-replete conditions and prevents flagellin-mediated immune recognition. Our results indicate that the production of two proteases with anti-flagellin activity provides a failsafe mechanism for P. aeruginosa to ensure the maintenance of protease-dependent immune-modulating functions. PMID:26502908

  17. Use of micronutrient supplements among pregnant women in Alberta: results from the Alberta Pregnancy Outcomes and Nutrition (APrON) cohort.

    PubMed

    Gómez, Mariel Fajer; Field, Catherine J; Olstad, Dana Lee; Loehr, Sarah; Ramage, Stephanie; McCargar, Linda J

    2015-10-01

    Maternal nutrient intake in the prenatal period is an important determinant of fetal growth and development and supports maternal health. Many women, however, fail to meet their prenatal nutrient requirements through diet alone and are therefore advised to consume nutrient supplements. The purpose of this study was to describe the use of natural health products (NHP) by pregnant women in each trimester of pregnancy. Women (n = 599) participating in the first cohort of the Alberta Pregnancy Outcomes and Nutrition (APrON) study completed an interviewer-administered supplement intake questionnaire during each trimester of pregnancy. NHP use was high, with >90% taking multivitamin/mineral supplements, and nearly half taking at least one additional single-nutrient supplement. Compliance with supplementation guidelines was high for folic acid (>90%), vitamin D (∼70%) and calcium (∼80%), but low for iron (<30%) and for all four nutrients together (≤11%). On average, women met or exceeded the recommended dietary allowance for folic acid, vitamin D and iron from NHPs alone, with median daily intakes of 1000 μg, 400 IU and 27 mg, respectively. The median calcium intake was 250 mg d(-1) . Up to 26% of women exceeded the tolerable upper intake level for folic acid and up to 19% did so for iron at some point of their pregnancy. Findings highlight the need to consider both dietary and supplemental sources of micronutrients when assessing the nutrient intakes of pregnant women. PMID:23557540

  18. Impaired epithelial differentiation of induced pluripotent stem cells from ectodermal dysplasia-related patients is rescued by the small compound APR-246/PRIMA-1MET.

    PubMed

    Shalom-Feuerstein, Ruby; Serror, Laura; Aberdam, Edith; Müller, Franz-Josef; van Bokhoven, Hans; Wiman, Klas G; Zhou, Huiqing; Aberdam, Daniel; Petit, Isabelle

    2013-02-01

    Ectodermal dysplasia is a group of congenital syndromes affecting a variety of ectodermal derivatives. Among them, ectrodactyly, ectodermal dysplasia, and cleft lip/palate (EEC) syndrome is caused by single point mutations in the p63 gene, which controls epidermal development and homeostasis. Phenotypic defects of the EEC syndrome include skin defects and limbal stem-cell deficiency. In this study, we designed a unique cellular model that recapitulated major embryonic defects related to EEC. Fibroblasts from healthy donors and EEC patients carrying two different point mutations in the DNA binding domain of p63 were reprogrammed into induced pluripotent stem cell (iPSC) lines. EEC-iPSC from both patients showed early ectodermal commitment into K18(+) cells but failed to further differentiate into K14(+) cells (epidermis/limbus) or K3/K12(+) cells (corneal epithelium). APR-246 (PRIMA-1(MET)), a small compound that restores functionality of mutant p53 in human tumor cells, could revert corneal epithelial lineage commitment and reinstate a normal p63-related signaling pathway. This study illustrates the relevance of iPSC for p63 related disorders and paves the way for future therapy of EEC. PMID:23355677

  19. Coseismic Dip Slip Distribution of the 1 Apr 2007 Solomon Islands Mw8.1 Earthquake from a Fully Bayesian Inversion

    NASA Astrophysics Data System (ADS)

    Chen, T.

    2009-12-01

    102 uplift and subsidence measurements over the southeastern end of the rupture zone from two field surveys shortly after 1 Apr 2007 Solomon Islands Earthquake provide a unique geodetic constraint in the following inversion of distributed slip. In the conventional inversion of geodetic data for spatial distribution of fault slip the solution is maintained by minimizing the second-order spatial derivative of slip and the smoothing parameter is often selected subjectively at the bend of the trade-off curve of misfit as a function of slip roughness. A fully Bayesian slip inversion method[Fukuda et al.,2008] is used to overcome the deficiency of selecting the smoothing parameter subjectively. The smoothing parameter is estimated with the distributed slip at the same time under a unified theoretical Bayesian framework. The joint posterior probability density function of distributed slip and smoothing parameter is formulated using Bayes’ theorem and sampled with Markov chain Monte Carlo method. I will apply this method to coseismic slip distribution associated with the 2007 Mw8.1 Solomon Islands earthquake and compare the results of this method with conventional method and the coseismic finite fault model of Furlong et al.[2009].

  20. Anti-leukaemic effects induced by APR-246 are dependent on induction of oxidative stress and the NFE2L2/HMOX1 axis that can be targeted by PI3K and mTOR inhibitors in acute myeloid leukaemia cells.

    PubMed

    Ali, Dina; Mohammad, Dara K; Mujahed, Huthayfa; Jonson-Videsäter, Kerstin; Nore, Beston; Paul, Christer; Lehmann, Sören

    2016-07-01

    The small molecule APR-246 (PRIMA-1(MET) ) is a novel drug that restores the activity of mutated and unfolded TP53 protein. However, the mechanisms of action and potential off-target effects are not fully understood. Gene expression profiling in TP53 mutant KMB3 acute myeloid leukaemia (AML) cells showed that genes which protected cells from oxidative stress to be the most up-regulated. APR-246 exposure also induced reactive oxygen species (ROS) formation and depleted glutathione in AML cells. The genes most up-regulated by APR-246, confirmed by quantitative real time polymerase chain reaction, were heme oxygenase-1 (HMOX1, also termed HO-1), SLC7A11 and RIT1. Up-regulation of HMOX1, a key regulator of cellular response to ROS, was independent of TP53 mutational status. NFE2L2 (also termed Nrf2), a master regulator of HMOX1 expression, showed transcriptional up-regulation and nuclear translocation by APR-246. Down-regulation of NFE2L2 by siRNA in AML cells significantly increased the antitumoural effects of APR-246. The PI3K inhibitor wortmannin and the mTOR inhibitor rapamycin inhibited APR-246-induced nuclear translocation of NFE2L2 and counteracted the protective cellular responses to APR-246, resulting in synergistic cell killing together with APR-246. In conclusion, ROS induction is important for antileukaemic activities of APR-246 and inhibiting the protective response of the Nrf-2/HMOX1 axis using PI3K inhibitors, enhances the antileukaemic effects. PMID:26991755

  1. Regulation of the aprX-lipA operon of Pseudomonas fluorescens B52: differential regulation of the proximal and distal genes, encoding protease and lipase, by ompR-envZ.

    PubMed

    McCarthy, Conor N; Woods, Rick G; Beacham, Ifor R

    2004-12-15

    The production of lipase and protease from psychrotrophic strains of Pseudomonas fluorescens may result in spoilage of dairy products. The lipase (lipA) and alkaline metalloprotease (aprX) genes of P. fluorescens B52 are regulated by temperature and are located at opposite ends of an operon which contains eight genes and spans 14 kb. In this report, we show that lipase activity in the supernatant of cultures of P. fluorescens strain B52 is also regulated by the homologue of the Escherichia coli EnvZ-OmpR two-component regulatory system. Differences in the regulation of lipase and protease may be related to the proximal and distal locations of aprX and lipA within the operon. PMID:15598539

  2. A scaling study of the natural circulation flow of the ex-vessel core catcher cooling system of EU-APR1400 for designing a scale-down test facility for design verification

    SciTech Connect

    Rhee, B. W.; Ha, K. S.; Park, R. J.; Song, J. H.; Revankar, S. T.

    2012-07-01

    In this paper a scaling study on the steady state natural circulation flow along the flow path of the ex vessel core catcher cooling system of EU-APR1400 is described, and the scaling criteria for reproducing the same steady state thermalhydraulic characteristics of the natural circulation flow as a prototype core catcher cooling system in the scale-down test facility are derived in terms of the down-comer pipe diameter and orifice resistance. (authors)

  3. Development of a murine nose-only inhalation model of influenza: comparison of disease caused by instilled and inhaled A/PR/8/34

    PubMed Central

    Bowen, Larry E.; Rivers, Katie; Trombley, John E.; Bohannon, J. Kyle; Li, Shixiong X.; Boydston, Jeremy A.; Eichelberger, Maryna C.

    2012-01-01

    Influenza continues to cause widespread disease and death during winter months. In preclinical studies to evaluate the potential efficacy of drugs and vaccines, influenza challenge virus is usually instilled into the noses of animals in the form of large liquid drops. Since inhalation of aerosolized influenza is commonly associated with human transmission, instillation of challenge virus raises uncertainty about the applicability of results. In order to compare the challenge methods, we established conditions to generate influenza aerosols with a mass median aerodynamic diameter (MMAD) of 1 μm that were delivered to mice in a nose-only inhalation system. In this report, we describe the system and compare the 50% lethal dose (LD50) of instilled and inhaled A/PR/8/34 (PR8) in BALB/c mice. The estimated LD50 for inhaled virus was 8.7 plaque forming units (PFU) and the mean time to death was 7.7 days, whereas the estimated LD50 for instilled virus was 51.6 PFU and the mean time to death was 8.2 days. Our results show that mice are more sensitive to inhaled virus than virus delivered by intranasal instillation. The murine nose-only inhalation model of influenza infection can be used to infect large numbers of animals simultaneously with well-characterized, homogenous PR8 bioaerosol in a controlled and reproducible manner. This model provides the means to evaluate the efficacy of drug and vaccine candidates against the relevant route of challenge, thereby providing data that may better predict clinical outcome. PMID:22919665

  4. Coadministration of Hedera helix L. Extract Enabled Mice to Overcome Insufficient Protection against Influenza A/PR/8 Virus Infection under Suboptimal Treatment with Oseltamivir.

    PubMed

    Hong, Eun-Hye; Song, Jae-Hyoung; Shim, Aeri; Lee, Bo-Ra; Kwon, Bo-Eun; Song, Hyuk-Hwan; Kim, Yeon-Jeong; Chang, Sun-Young; Jeong, Hyeon Gun; Kim, Jong Geal; Seo, Sang-Uk; Kim, HyunPyo; Kwon, YongSoo; Ko, Hyun-Jeong

    2015-01-01

    Several anti-influenza drugs that reduce disease manifestation exist, and although these drugs provide clinical benefits in infected patients, their efficacy is limited by the emergence of drug-resistant influenza viruses. In the current study, we assessed the therapeutic strategy of enhancing the antiviral efficacy of an existing neuraminidase inhibitor, oseltamivir, by coadministering with the leaf extract from Hedera helix L, commonly known as ivy. Ivy extract has anti-inflammatory, antibacterial, antifungal, and antihelminthic properties. In the present study, we investigated its potential antiviral properties against influenza A/PR/8 (PR8) virus in a mouse model with suboptimal oseltamivir that mimics a poor clinical response to antiviral drug treatment. Suboptimal oseltamivir resulted in insufficient protection against PR8 infection. Oral administration of ivy extract with suboptimal oseltamivir increased the antiviral activity of oseltamivir. Ivy extract and its compounds, particularly hedrasaponin F, significantly reduced the cytopathic effect in PR8-infected A549 cells in the presence of oseltamivir. Compared with oseltamivir treatment alone, coadministration of the fraction of ivy extract that contained the highest proportion of hedrasaponin F with oseltamivir decreased pulmonary inflammation in PR8-infected mice. Inflammatory cytokines and chemokines, including tumor necrosis factor-alpha and chemokine (C-C motif) ligand 2, were reduced by treatment with oseltamivir and the fraction of ivy extract. Analysis of inflammatory cell infiltration in the bronchial alveolar of PR8-infected mice revealed that CD11b+Ly6G+ and CD11b+Ly6Cint cells were recruited after virus infection; coadministration of the ivy extract fraction with oseltamivir reduced infiltration of these inflammatory cells. In a model of suboptimal oseltamivir treatment, coadministration of ivy extract fraction that includes hedrasaponin F increased protection against PR8 infection that could be

  5. Coadministration of Hedera helix L. Extract Enabled Mice to Overcome Insufficient Protection against Influenza A/PR/8 Virus Infection under Suboptimal Treatment with Oseltamivir

    PubMed Central

    Shim, Aeri; Lee, Bo-Ra; Kwon, Bo-Eun; Song, Hyuk-Hwan; Kim, Yeon-Jeong; Chang, Sun-Young; Jeong, Hyeon Gun; Kim, Jong Geal; Seo, Sang-Uk; Kim, HyunPyo; Kwon, YongSoo; Ko, Hyun-Jeong

    2015-01-01

    Several anti-influenza drugs that reduce disease manifestation exist, and although these drugs provide clinical benefits in infected patients, their efficacy is limited by the emergence of drug-resistant influenza viruses. In the current study, we assessed the therapeutic strategy of enhancing the antiviral efficacy of an existing neuraminidase inhibitor, oseltamivir, by coadministering with the leaf extract from Hedera helix L, commonly known as ivy. Ivy extract has anti-inflammatory, antibacterial, antifungal, and antihelminthic properties. In the present study, we investigated its potential antiviral properties against influenza A/PR/8 (PR8) virus in a mouse model with suboptimal oseltamivir that mimics a poor clinical response to antiviral drug treatment. Suboptimal oseltamivir resulted in insufficient protection against PR8 infection. Oral administration of ivy extract with suboptimal oseltamivir increased the antiviral activity of oseltamivir. Ivy extract and its compounds, particularly hedrasaponin F, significantly reduced the cytopathic effect in PR8-infected A549 cells in the presence of oseltamivir. Compared with oseltamivir treatment alone, coadministration of the fraction of ivy extract that contained the highest proportion of hedrasaponin F with oseltamivir decreased pulmonary inflammation in PR8-infected mice. Inflammatory cytokines and chemokines, including tumor necrosis factor-alpha and chemokine (C-C motif) ligand 2, were reduced by treatment with oseltamivir and the fraction of ivy extract. Analysis of inflammatory cell infiltration in the bronchial alveolar of PR8-infected mice revealed that CD11b+Ly6G+ and CD11b+Ly6Cint cells were recruited after virus infection; coadministration of the ivy extract fraction with oseltamivir reduced infiltration of these inflammatory cells. In a model of suboptimal oseltamivir treatment, coadministration of ivy extract fraction that includes hedrasaponin F increased protection against PR8 infection that could be

  6. Inhibitory effect of cinnamaldehyde, derived from Cinnamomi cortex, on the growth of influenza A/PR/8 virus in vitro and in vivo.

    PubMed

    Hayashi, K; Imanishi, N; Kashiwayama, Y; Kawano, A; Terasawa, K; Shimada, Y; Ochiai, H

    2007-04-01

    We have investigated the inhibitory effect of trans-cinnamaldehyde (CA), one of the principal constituents of essential oil derived from Cinnamomi cortex, on the growth of influenza A/PR/8 virus in vitro and in vivo. When 1-h drug treatment was initiated at various times post-infection (p.i.) in Madin-Darby canine kidney cells using a fixed dose of CA (40 microM), the maximum inhibitory effect (29.7% virus yield of control) was obtained when drug treatment was started at 3h p.i. Under the same treatment schedule, CA inhibited the virus growth in a dose-dependent manner (20-200 microM), and, at 200 microM, the virus yield was reduced to an undetectable level. RT-PCR and SDS-PAGE analyses showed that CA inhibited viral protein synthesis at the post-transcriptional level. In mice infected with the lung-adapted PR-8 virus, inhalation (50mg/cage/day) and nasal inoculation (250 microg/mouse/day) of CA significantly increased survival rates on the 8 days to 100% and 70%, respectively, in contrast to a survival rate of 20% in the untreated control group. Importantly, inhalation of CA caused virus yield reduction by 1 log in bronchoalveolar lavage fluid on day 6 after infection, compared with that of the untreated control group. These findings might provide further support to the empirical indication of Cinnamomi cortex-containing Kampo medicines for acute respiratory infectious diseases. PMID:17303260

  7. Première expérience de l'utilisation du Misoprostol comme soin après avortement (SAA) à Libreville, Gabon

    PubMed Central

    Mayi-Tsonga, Sosthène; Minkobame, Ulysse; Mbila, Arielle; Assoumou, Pamphile; Diop, Ayisha; Winikoff, Beverly

    2014-01-01

    Introduction Une étude a été menée afin de déterminer le taux d'acceptabilité de 400µg de misoprostol par voie sublinguale comme traitement de première intention de l'avortement incomplet et de préciser le taux d'avortement complet ou vacuité utérine. Méthodes Les femmes éligibles avaient un diagnostic clinique d'avortement incomplet avec une taille utérine inférieure à celle d'un utérus de 12 semaines d'aménorrhées (SA). Chacune a reçu 400µg de misoprostol par voie sublinguale. Les femmes ont été revues après une semaine. A J7, celles qui n'avaient pas complètement expulsé ont eu le choix entre une nouvelle consultation de suivi à J14 et la pratique d'une évacuation chirurgicale immédiate. Résultats 145 patientes ont été éligibles et ont toutes accepté la méthode (100%). L’âge moyen était de 25,9 ± 6 ans. A J7, 120 patientes étaient guéries (85,7%). A J14, le taux de réussitea été de 95,7% soit 134 patientes guéries. Les patientes guéries ont déclaré être très satisfaites (57,5%), satisfaites (41,8%) et insatisfaite (0,7%). Au total,128 femmes (95,5%) ont dit être prêtes à utiliser de nouveau le misoprostol comme méthode d’évacuation utérine en cas d'avortement incomplet. Conclusion L’étude démontre que le 400µg misoprostol par voie sublinguale nous permet de prendre en charge d'une manière adéquate l'avortement incomplet surtout dans les pays à faible ressource et notamment dans les structures sanitaires de première ligne ou éloignées. PMID:25469194

  8. A study on the effect of various design parameters on the natural circulation flow rate of the ex-vessel core catcher cooling system of EU-APR1400

    SciTech Connect

    Rhee, B. W.; Ha, K. S.; Park, R. J.; Song, J. H.

    2012-07-01

    In this paper, a study on the effect of various design parameters such as the channel gap width, heat flux distribution, down-comer pipe size and two-phase flow slip ratio on the natural circulation flow rate is performed based on a physical model for a natural circulation flow along the flow path of the ex-vessel core catcher cooling system of an EU-APR1400, and these effects on the natural circulation flow rate are analyzed and compared with the minimum flow rate required for the safe operation of the system. (authors)

  9. Complications métaboliques après transplantation rénale à partir du donneur vivant: expérience du CHU Ibn Sina de Rabat

    PubMed Central

    Mouram, Hala; Benamar, Loubna; Ouzeddoune, Naima; Bayahia, Rabia; Ezaitouni, Fatima

    2014-01-01

    La transplantation rénale (TR) constitue le traitement de choix de l'insuffisance rénale chronique terminale. Les complications métaboliques après TR (diabète, dyslipidémie, hyperuricémie, obésité), en grande partie liées au traitement immunosuppresseur, deviennent une préoccupation car elles constituent un facteur de risque de morbimortalité et de perte fonctionnelle du greffon. Le but de notre étude est d’évaluer la fréquence de ces anomalies après TR. Il s'agit d'une étude rétrospective incluant tous les patients ayant bénéficié d'une première TR par donneur vivant (DV) de Juin 1998 à Décembre 2010. Nous avons recensé les données démographiques propres au receveur, le traitement immunosuppresseur après TR. Les paramètres clinico-biologiques recueillis sont (index de masse corporel (IMC), glycémie à jeun, hémoglobine glyquée, CT, C-HDL, C-LDL, TG, acide urique). Soixante dix patients ont été colligés, l’âge moyen est de 36.3 + /-9.6 ans (21 à 62) avec un sex ratio de 0.5. Quinze patients (21.4%) étaient hypertendus avant la TR et 2.9% avaient une néphropathie diabétiques. L’âge moyen du donneur est de 47.5 + /-10.2 ans (20-65). Le traitement immunosuppresseur pendant la phase d'induction était une trithérapie associant corticostéroïdes, anticalcineurines chez tous les patients et mycophénolate mofétil chez 68.6% et azathioprine dans 31.4% des cas. L'IMC moyen était de 24.1 + /-4.0 (16.9 à 37), 33% des patients étaient considérés en surpoids dont 21.8% en obésité. L'hypercholestérolémie, a été retrouvée chez 25 patients soit 36%. Presque la moitié des patients (48.5%) avaient une hyperuricémie. Quatre patients ont développé un diabète après TR soit 6% des cas. La perte du greffon a été notée chez 12 patients et 2 patients sont décédés dont un avec un greffon fonctionnel. En analyse univariée, l'hyperuricémie et la dyslipidémie ont été considérées comme facteur de risque de perte

  10. Influence du débit et de la répartition de dose sur l'incidence des cancers pulmonaires après inhalation d'émetteurs

    NASA Astrophysics Data System (ADS)

    Fritsch, P.; Dudoignon, N.; Morlier, J. P.; Monchaux, G.; Morin, M.

    1998-04-01

    We have discussed experimental results reported on the influence of dose rate and dose distribution on the incidence of lung tumors after inhalation exposure to α emitters. New experiments have been carried out to characterize the range of tumor risk which could vary over more than a factor 20 depending on the α activity of the inhaled particles. Long term effects induced in rats after inhalation of poorly soluble 237NpO2 and industrial PuO2 with a similar granulometry will be compared, the specific activities of which varying within a factor 500. Nous avons rapporté les différentes données expérimentales de cancérogenèse pulmonaire qui montrent une variation du risque d'induction des tumeurs après inhalation de radionucléides émetteurs α selon le débit et la répartition de dose. De nouvelles expérimentations ont été initiées afin de préciser ces variations qui s'étalent sur plus d'un facteur 20. Elles consistent à comparer les effets induits chez le rat après exposition à des aérosols de 237NpO2 et de PuO2 d'origine industrielle peu solubles et de granulométrie analogue dont les activités spécifiques diffèrent d'un facteur 500.

  11. Tomographie par coherence optique pour le guidage de chirurgies minimalement invasives du rachis

    NASA Astrophysics Data System (ADS)

    Beaudette, Kathy

    Adolescent idiopathic scoliosis is a complex 3D deformity of the spine which requires surgical intervention in severe cases of the condition. The existing corrective procedure of scoliosis is very invasive; it involves a long incision and a large instrumentation, in addition to the fusion of a section of the spine. To improve postoperative conditions and to preserve patients' spinal flexibility, novel fusionless surgical approaches involving growth modulation are under investigation. With this objective in mind, a multidisciplinary team from École Polytechnique of Montreal and Sainte-Justine University Hospital Research Center is developing a surgical technique based on the insertion of micro-staples between vertebral growth plates and corresponding intervertebral disks. Each micro-staple passively modulates the vertebral growth on the convex side of the scoliotic curvature. This modulation modifies vertebral geometry which, for scoliotic patients, presents a wedging deformity. The modulation induced by these devices could lead to the correction of the curvature of the spine. This innovative procedure would preserve the flexibility of the spine as well as the health of intervertebral disks, in addition to being compatible with minimally invasive approaches. However, to be efficient, the micro-staples must be placed at the junction between the growth plate and the disk with a sub-millimeter precision. An intraoperative guiding system is therefore required to ensure the success of the intervention. Optical coherence tomography (OCT) is a promising candidate for this application. OCT is based on low-coherence interferometry and provides cross-sectional images with a resolution about 10 μm for a depth of 2 to 3 mm. This technique allows for the real-time acquisition of images and is compatible with endoscopy, thereby showing a potential for the intraoperative guidance of minimally invasive surgeries (MIS) of the spine. The main objective of this master's project is therefore to evaluate the possibility of using OCT to localize as well as identify spinal structures (such as growth plates, osseous tissue, intervertebral disks and connective tissue) and to guide the insertion of micro-staples. To attain this objective, an OCT handheld probe was designed and developed according to the surgical constraints of MIS performed by thoracoscopy (through the thorax). This probe has an external diameter of 17 mm and is 30 cm long. Coupled with a fibered interferometer, the axial and lateral resolutions of the probe are of 16 and 27 μm respectively. The OCT probe was used in vivo during an open surgery on a porcine model. Different tissues within the operative window (lung, muscles, osseous tissues and intervertebral disk) were imaged during the procedure. These preliminary in vivo tests demonstrated that the probe is capable of identifying different types of tissue with a good sensitivity and an adequate penetration depth. These results also showed that a visual inspection of the in vivo OCT images alone is not sufficient to localize the growth plates on the vertebrae. An ex vivo study using porcine vertebrae was therefore performed to identify quantitative markers in order to facilitate the interpretation of in vivo OCT images. OCT images were initially compared to corresponding histological sections. The ensuing results showed that the connective tissue layer presents a band pattern due to the birefringence properties of the collagen-rich tissue. The intervertebral disk was also shown to have a characteristic lamellar structure on OCT images. Lastly, within growth plate and osseous tissue locations, the OCT signal decay is monotonic, but with different attenuation coefficients (different slopes). Relative attenuation coefficients were therefore measured for each tissue (growth plate, osseous tissue, connective tissue and intervertebral disk) on several specimens and were compared. These results showed that growth plates present an average relative attenuation coefficient statistically different from the other tissues. An automatic growth plate segmentation algorithm was then developed and tested. The algorithm was applied to images from an ex vivo specimen of a porcine vertebra and successfully identified most of the growth plate (> 75%) amidst the osseous tissue of the vertebral body and the intervertebral disk. This master's project shows that OCT presents contrast, resolution and penetration depth that are sufficient for the identification of musculoskeletal structures of the spine. It is thus reasonable to believe that, ultimately, OCT could be used for the intraoperative guiding of the insertion of micro-staples during corrective surgeries of scoliosis.

  12. Application de la méthode de Laue refocalisée à haute énergie à l'étude des mécanismes de recristallisation après déformation à froid de métaux CFC

    NASA Astrophysics Data System (ADS)

    Chauveau, Th.; Gerber, Ph.; Bastie, P.; Hamelin, B.; Tarasiuk, J.; Bacroix, B.

    2002-07-01

    In order to determine the kinetics of recystallization process, the Laue diffraction method is apllied here on cold rolled and recrystallized copper materials. Firts, the results obtained from reflexion X-ray diffraction texture measurements are presented. It is shown that the both techniques are complementar, and that the transmission Laue method presents some advantadges. Some previous hypotheses are verified in this work. Especially, the Cube orientation \\{100\\} <001> loses during recrystallization its advantadge of growth, which implies the development of a mixed “deformed-recrystallized” texture at the end of the process. The nucleation step determines the final recrystallized texture. La méthode de Laue haute énergie est appliquée ici dans le but de déterminer les cinétiques de recristallisation de matériaux cuivre après laminages à froid et recuits interrompus. Après présentation des résultats obtenus par mesures classiques en réflexion, une comparaison est effectuée entre les deux techniques permettant de rendre compte des avantages certains qu'offrent des mesures en transmission et de la complémentarité des deux techniques utilisées. Quelques hypothèses sur les mécanismes régissant le processus de recristallisation sont ainsi vérifiées. Au tout début du processus de recristallisation, il a clairement été mis en évidence une perte de l'avantage de croissance des germes d'orientation Cube \\{100\\} <001> au profit des composantes constituant la texture de déformation. Dans ce type de processus, n'est préférentielle que l'étape de germination, dans le sens où elle détermine la texture finale après recristallisation.

  13. Protocols for evaluating oxidant mechanisms for urban and regional models. Rept. for Apr 89-Apr 92

    SciTech Connect

    Jeffries, H.E.; Gery, M.W.; Carter, W.P.L.

    1992-06-01

    Procedures have been developed for evaluating chemical kinetics mechanisms that are candidates for use in urban and regional air quality simulation models. To accomplish the goal, a task force of experimentalists and modelers was assembled to address issues related to developing protocols for evaluating mechanisms against smog chamber data. The efforts of the task force were scrutinized in two workshops attended by national and international experts on smog chamber experimentation and model development. Based on the work undertaken by the task force and the input received from the committee of experts, a protocol was formulated that involves testing mechanisms against a standard data base of smog chamber experiments. The protocol describes the types and number of chamber experiments that should be used in the evaluation and how the evaluation should be conducted.

  14. Surface-Based Observations of Contrail Occurrence Over the US, Apr. 1993 to Apr. 1994

    NASA Technical Reports Server (NTRS)

    Minnis, Patrick; Ayers, J. Kirk; Weaver, Steven P.

    1997-01-01

    Surface observers stationed at 19 U.S. Air Force Bases and Army Air Stations recorded the daytime occurrence of contrails and cloud fraction on an hourly basis for the period April 1993 through April 1994. Each observation uses one of four main categories to report contrails as unobserved, non-persistent, persistent, and indeterminate. Additional classification includes the co-occurrence of cirrus with each report. The data cover much of the continental U.S. including locations near major commercial air routes. The mean annual frequency of occurrence in unobstructed viewing conditions is 13 percent for these sites. Contrail occurrence varied substantially with location and season. Most contrails occurred during the winter months and least during the summer with a pronounced minimum during July. Although nocturnal observations are not available, it appears that the contrails have a diurnal variation that peaks during mid morning over most areas. Contrails were most often observed in areas near major commercial air corridors and least often over areas far removed from the heaviest air traffic. A significant correlation exists between mean contrail frequency and aircraft fuel usage above 7 km suggesting predictive potential for assessing future contrail effects on climate.

  15. 15 CFR 740.16 - Additional permissive reexports (APR).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... foreign-made product, subject to the restrictions in § 734.4 of the EAR. (i) Reexports to Sudan of items... knowledge that they will be reexported directly or indirectly, in whole or in part to Sudan is...

  16. 15 CFR 740.16 - Additional permissive reexports (APR).

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... foreign-made product, subject to the restrictions in § 734.4 of the EAR. (i) Reexports to Sudan of items... knowledge that they will be reexported directly or indirectly, in whole or in part to Sudan is...

  17. 15 CFR 740.16 - Additional permissive reexports (APR).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... North Korea and the commodity being reexported is controlled for national security reasons. (b..., South Korea, Spain, Sweden, Switzerland, Turkey, and the United Kingdom if: (i) Such cameras are...

  18. Asteroid Lightcurve Analysis at the Danhenge Observatory Apr - Aug 2011

    NASA Astrophysics Data System (ADS)

    Coley, Daniel

    2012-01-01

    The lightcurves for three main-belt asteroids, 1413 Roucarie, 3385 Bronnina, and 39890 Bobstephens. All observations were taken from the DanHenge Observatory, one of 13 observatories at Goat Mountain Astronomical Research Station (GMARS - MPC G79).

  19. 15 CFR 740.16 - Additional permissive reexports (APR).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Supplement No. 1 to part 740), other than North Korea and the commodity being reexported is controlled for... Africa, South Korea, Spain, Sweden, Switzerland, Turkey, and the United Kingdom if: (i) Such cameras...

  20. 15 CFR 740.16 - Additional permissive reexports (APR).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... supplement No. 1 to part 740), other than North Korea and the commodity being reexported is controlled for... Africa, South Korea, Spain, Sweden, Switzerland, Turkey, and the United Kingdom if: (i) Such cameras...

  1. Reduction of hexachloroethane and carbon tetrachloride at surfaces of biotite, vermiculite, pyrite, and marcasite. Book chapter Apr 88-Apr 90

    SciTech Connect

    Kriegman-King, M.R.; Reinhard, M.

    1991-01-01

    Contamination of groundwater resources by halogenated compounds spurred the formation of a national program to clean up hazardous waste sites across the United States. Compounds such as carbon tetrachloride (CTET), chloroform (CF), and hexachloroethane (HCA) are a few of the chemicals which have been proposed to be 'characteristic' hazardous wastes to be included in the toxic contaminant leachate potential (TCLP) test. Consequently, chemical and biological transformation pathways are being studied to aid in understanding the fate of these contaminants in groundwater environments and to apply the processes occurring naturally in groundwater environments to remediation technologies. Environmental factors significantly affect the transformation rates and the pathways of halogenated aliphatic compounds. The authors have studied the transformation of tetrachloromethane (CTET), and hexachloroethane (HCA) in homogenous and heterogenous systems designed to simulate groundwater and sediment conditions. The laboratory studies were aimed at (1) identifying the sediment components which may act as reducing components and (2) quantifying the environmental factors which govern the transformation rates. Both model and natural systems were studied. Their data indicate that the humic acid fraction in combination with sulfide and Fe(2+) may promote transformation rates. Similarly, surfaces of sheet silicates, such as biotite and vermiculite, were found to promote degradation of CTET and perchloroethylene, respectively.

  2. Paragangliome rétropéritonéal non secrétant: une cause rare d'occlusion intestinale haute

    PubMed Central

    Soufi, Mehdi; Benamr, Said; Chad, Bouziane

    2014-01-01

    Les paragangliomes sont des tumeurs neuroendocrines rares diagnostiquées le plus souvent chez le jeune adulte. Nous rapportons le cas rare d'une jeune femme de 20 ans présentant un paragangliome rétropéritonéal situé sur la face antérolatérale de l'aorte et comprimant l'angle duodéno-jéjunal responsable d'un syndrome subocclusif haut. Dans les formes non sécrétantes, la symptomatologie est souvent déroutante. Le diagnostic n'est généralement fait qu'après examen histologique de la pièce de résection. Le traitement de choix repose sur une chirurgie carcinologique intégrant une concertation multidisciplinaire. PMID:25469205

  3. La trochantérite tuberculeuse, un diagnostic souvent difficile

    PubMed Central

    Mhammdi, Younes; Boufettal, Moncef; Kharmaz, Mohamed; Lahlou, Abdou; Mahfoud, Mustapha; EL Bardouni, Ahmed; Berrada, Mohamed Saleh

    2016-01-01

    La trochantérite tuberculeuse est une affection rare (<2% des tuberculoses ostéo-articulaires), même en pays à forte endémie, elle est caractérisée par une symptomatologie insidieuse rendant souvent son diagnostic tardif. Les auteurs rapportent une série de 9 cas, le diagnostic a été posé sur des études bactériologiques et histologiques après un bilan d'imagerie (échographie, IRM, TDM). Le traitement de cette affection est médical (antibiothérapie antituberculeuse), et la chirurgie ne trouve sa place qu'en cas de complications et permet d'améliorer l’évolution. PMID:27279938

  4. Lead detection and mapping with reference to relationships between scale, sensor characteristics, surface conditions, and atmospheric properties. Annual report, 15 Apr 91-14 Apr 92

    SciTech Connect

    Key, J.; Stone, R.S.; Maslanik, J.A.; Ellefsen, E.

    1992-04-20

    During the first two years of the project, empirical studies of scale relationships in the retrieval of sea ice lead statistics have been undertaken, as have modeling investigations of atmospheric influences on the satellite signal. Additionally, we have developed statistical models that describe the scaling properties of leads. The empirical studies have been based primarily on comparisons within and between Landsat and AVHRR imagery, while the atmospheric models have been specific to the AVHRR. Submarine sonar data have been used in the statistical model development. Specific accomplishments to date include: The parameterizations of clouds, haze, and atmospheric chemical constituents in the LOWTRAN 7 radiative transfer model have been reviewed. Atmospheric temperature and humidity profiles for the arctic have been constructed from Soviet ice island data and are being used in the model. Resampling methods have been tested on simulated, AVHRR, and Landsat images, as have the effects of digital enhancements. Procedures for the retrieval of lead statistics have been developed and applied to Landsat imagery successively degraded to more coarse resolutions.

  5. Chronic effects of JP-8 jet-fuel exposure on the lungs. Annual report, 1 Apr 91-1 Apr 92

    SciTech Connect

    Witten, M.L.

    1992-04-23

    This research has resulted in four separate projects. The first was the exposure of Fischer 344 rats to JP-8 jet fuel for 7 or 28 days. This exposure resulted in changes in pulmonary function and lung chemical mediators, specifically Substance P, after 28 days of exposure. The second project dealt with blocking the increase in SP in these rats by a pretreatment regimen with capsaicin before jet fuel exposure. Capsaicin caused a further increase in lung permeability and a million-fold increase in airway sensitivity to histamine after the 7-day jet fuel exposure. The third project dealt with the effects of a 7-day jet fuel exposure in congenic mice who are deficient in the inducibility of the aryl hydrocarbon hydroxylase enzyme. These mice are relatively resistant to the effects of jet fuel-induced lung injury. The fourth project investigated the effects of the jet fuel exposure on secondary organs, specifically the liver, spleen, and kidneys. There were pathological differences in the liver, spleen, and kidneys between the 7-day jet fuel exposure group and baseline controls. However, some of these differences were not apparent in the 28-day exposure group, possibly indicating compensatory mechanisms to the exposure.

  6. Radio-chimiothérapie adjuvante des adénocarcinomes gastriques: à propos de 34 cas et d'une revue de la literature

    PubMed Central

    James, Laurianne; Dossou, Sepos; Bellfiq, Sarah; Irigo, Joëlle; Ogandaga, Etienne; Mouden, Karima; Loughmari, Saïda; Filali, Dounia; El Majjaoui, Sanaa; Kebdani, Tayeb; Ahid, Samir; Benjafaar, Nourredine

    2014-01-01

    Notre étude consistera en l’évaluation du pronostic des patients porteurs d'un adénocarcinome gastrique opérés et traités par radio-chimiothérapie adjuvante en technique conformationnelle. Entre Janvier 2007 et Décembre 2011, 34 patients ont reçu après une chirurgie radicale (R0 ou R1), un à trois cycles de 5-Fluoro-uracile associé à de l'Elvorine en adjuvant, suivi d'une radio-chimiothérapie selon le même protocole à la dose de 45Gy, puis de deux cycles de chimiothérapie à un mois d'intervalle après la radio-chimiothérapie concomitante. Dans le groupe d’étude, il y avait 34 patients d’âge médian 50 ans (47-58), avec un sexe ratio (H/F) de 2,4. Une chirurgie de type R1 a été réalisée dans 26,5% des cas, et 53% des patients étaient de stade III-IV. Le rapport nombres de ganglions positifs, sur nombre de ganglions prélevés étaient > 0,4 dans 26,5% des cas. Durant le traitement mené à terme, une neutropénie de grade III a été observée chez quatre patients, avec des troubles digestifs (nausées, vomissement, ou diarrhée) de grade I/II dans la majorité des cas. Après un suivi médian de 20 mois, 70,6% des patients étaient en survie sans rechute, et 29,4% ont présenté une récidive métastatique; la survie globale à 5 ans était de 35,4% et la survie sans progression de 58,7%. La radio-chimiothérapie concomitante postopératoire pourrait être un régime efficace et sûre chez les patients ayant bénéficié d'une gastrectomie à visée curative dans le cancer de l'estomac localement avancé. PMID:25709728

  7. Anesthésie pour prothése totale de la hanche: à propos de 50 cas

    PubMed Central

    Serghini, Issam; Qamouss, Youssef; Zoubir, Mohamed; Lalaoui, Jaafar Salim; Koulali, Idrissi Khalid; Boughalem, Mohamed

    2015-01-01

    La chirurgie de la prothèse totale de la hanche (PTH) est une chirurgie fonctionnelle qui consiste en un remplacement d'une articulation endommagée afin d'améliorer la qualité de vie du patient. L'anesthésie pour PTH exige une préparation rigoureuse à l'intervention, la consultation d'anesthésie sera donc la clef de cette réussite. Nous avons réalisé une étude rétrospective concernant 60 arthroplasties totales de la hanche implantées chez 50 patients adultes, colligée au sevice de Traumatologie et de chirurgie orthopédique à l'Hôpital Militaire Avicenne de Marrakech sur une période étalée de Janvier 2010 au Décembre 2012. Nous avons évalué la prise en charge anesthésique: pré, per et postopératoire des patients opérés pour une PTH. La moyenne d’âge était de 56,5 ans, le sex-ratio était de 1,63 en faveur des hommes. L'indication prédominante était la coxarthrose primitive. L'anesthésie générale était la technique anesthésique la plus utilisée (66% des cas), l'intubation difficile était rencontrée chez 6% de nos patients. La durée moyenne de l'acte chirurgical était de 114 +/- 25,33 mn. 12% de nos patients ont présenté une hypotension artérielle peropératoire. L'incidence de la transfusion homologue perop était de 14%. Nous avons noté 08 cas de complications postop: 03 cas d'infection de la PTH 15 jours après l'intervention, 03 cas de descellement aseptique, 01 cas de luxation de PTH et 01 cas de descellement septique avec un recul moyen de 54 mois. PMID:27047619

  8. Anévrismes de l'aorte abdominale sous-rénale rompus: aspects chirurgicaux à Dakar: à propos de 6 observations

    PubMed Central

    Dieng, Papa Adama; Diop, Momar Sokhna; Ba, Papa Salmane; Diatta, Souleymane; Gaye, Magaye; Sow, Ndeye Fatou; Diagne, Papa Amath; Sene, Etienne Birame; Ciss, Amadou Gabriel; Ndiaye, Assane; Ndiaye, Mouhamadou

    2015-01-01

    La rupture des anévrismes de l'aorte est une situation catastrophique. La chirurgie ouverte et le traitement endovasculaire sont débattus comme option. Dans cette étude sont évaluées les modalités du traitement chirurgical et ses résultats sur 6 malades opérés pour rupture d'un anévrysme de l'aorte abdominale sous-rénale. Dans 4 cas, il s'agissait d'une « rupture contenue » dans le péritoine pariétal postérieur, avec un hématome péri vertébral. Dans les 2 autres cas, il s'agissait d'une rupture en péritoine libre. Tous les malades avaient bénéficié après contrôle de l'hémostase d'une mise à plat de l'anévrisme suivie de greffe d'une prothèse aortique. Des complications précoces étaient notées chez 2 patients à type d'insuffisance rénale aigue et de poussée hypertensive. La mortalité opératoire était de 16,66%. La morbi-motalité des anévrismes rompus de l'aorte abdominale est particulièrement élevée, d'où la nécessité d'un dépistage précoce des patients à risque et l'introduction de la chirurgie endovasculaire. PMID:26587142

  9. Les Cicatrices Retractiles Post-Brulures Du Membre Inferieur Chez L’Enfant

    PubMed Central

    Sankale, A.A.; Manyacka Ma Nyemb, P.; Coulibaly, N.F.; Ndiaye, A.; Ndoye, M.

    2010-01-01

    Summary Il s'agit d'une étude faisant ressortir les aspects épidémiologiques, cliniques et thérapeutiques des séquelles de brûlures du membre inférieur chez l'enfant, à propos de 42 cas colligés au service de chirurgie infantile de l'Hôpital Aristide Le Dantec (Sénégal). L'âge moyen retrouvé est de 5 ans et 3 mois, et le sex-ratio garçons/filles de 1,8/1. La brûlure thermique est causée par une flamme dans 33% des cas, par un liquide chaud dans 21% des cas, et par des braises dans 21% des cas. Les cicatrices rétractiles intéressent le genou et le creux poplité dans 47% des cas et le pied dans 45% des cas. Elles sont bilatérales dans 21% des cas, et concernent une autre localisation associée dans 21% des cas. Quant aux brides, 21% ont bénéficié d'une chirurgie, avec un délai moyen de 3 ans et 2 mois après la brûlure. Cette procédure chirurgicale consiste en une plastie en Z dans 91% des cas, à laquelle est associée une greffe de peau dans 54% des cas. Une rééducation fonctionnelle est pratiquée chez 54% des opérés. Parallèlement aux données de la littérature, nos résultats montrent que l'optimisation de la prise en charge passe par une meilleure prévention des accidents domestiques et une bonne codification thérapeutique. PMID:21991202

  10. Oncoplastie avec conservation mammaire dans le traitement du cancer du sein: à propos de 16 cas

    PubMed Central

    Bouzoubaa, Wail; Laadioui, Meryam; Jayi, Sofia; Alaoui, Fatime Zahra Fdili; Bouguern, Hakima; Chaara, Hikmat; Melhouf, Moulay Abdelilah

    2015-01-01

    Le cancer du sein est actuellement le cancer le plus fréquent chez la femme, et pose un véritable problème diagnostique et thérapeutique. Le dépistage des lésions à un stade de plus en plus précoce, a permis une extension des indications du traitement conservateur radiochirurgical, qui était initialement limitées aux tumeurs de moins de 3 cm, unifocales, non inflammatoires. Par ailleurs, l'utilisation de traitements préopératoires permet d’étendre les indications du traitement conservateur à des tumeurs plus volumineuses. Parallèlement à cette extension des indications de conservation mammaire, on a observé le développement de nouvelles approches thérapeutiques notamment la chirurgie oncoplastique, technique du ganglion sentinelle et chirurgie stéréotaxique, dont les résultats initiaux sont très encouragent. A travers cette étude réalisée dans le service de gynécologie et obstétrique II du CHU HASSAN II de FES au MAROC, après l'analyse rétrospective de 16 patientes traitées par traitement conservateur et oncoplastie, nous avons voulus montrer notre aptitude a réalisé ses techniques chirurgicales et a bien prendre en charge ces patientes, mais aussi évaluer ces techniques en termes de résultat carcinologique et de résultat esthétique, aussi en terme de survie globale, survie sans métastase et en termes de récidive locale entre les plasties mammaires et les traitements usuels: mastectomie et traitement conservateur classique. PMID:26430477

  11. Subregional variability in Missouri tornado statistics. Technical report Apr 77-Jun 79

    SciTech Connect

    Jamison, S.W.; Darkow, G.L.

    1981-11-01

    The reality of subregional variability in tornado occurrence density as evidenced in the county to county variability in Missouri is examined. Reported tornadoes for the period from 1916 through 1975 were used. Demographic and geographic factors known to impact on tornado reporting efficiencies and accuracies are related to county tornado report densities by step-wise multiple linear regression techniques. The analysis suggests that over 75 percent of the county to county apparent variability in reported tornado densities in Missouri is explainable in terms of variability in population density, other related demographic variables and regional scale geographic factors.

  12. 15 CFR 781.1 - Definitions of terms used in the Additional Protocol Regulations (APR).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... CFR parts 781 to 786 that were promulgated by the Department of Commerce to implement and enforce the... Weapons (NPT). ITAR. The International Traffic in Arms Regulations (22 CFR Parts 120-130), which are... United States of America and the International Atomic Energy Agency for the Application of Safeguards...

  13. Science of artificial neural networks; Proceedings of the Meeting, Orlando, FL, Apr. 21-24, 1992

    SciTech Connect

    Ruck, D.W.

    1992-01-01

    The present conference discusses high-order neural networks with adaptive architecture, a parallel cascaded one-step learning machine, stretch and hammer neural networks, visual grammars for neural networks, the net pruning of a multilayer perceptron, neural correlates of the sensorial and cognitive control of behavior, neural nets for massively parallel optimization, parametric and additive perturbations for global optimization, design rules for multilayer perceptrons, the negative transfer problem in neural networks, and a vision-based neural multimap pattern recognition architecture. Also discussed are function prediction with recurrent neural networks, fuzzy neural computing systems, edge detection via fuzzy neural networks, modeling confusion for autonomous systems, self-organization by fuzzy clustering, neural nets in information retrieval, neighborhoods and trajectories in Kohonen maps, the random structure of error surfaces, and conceptual recognition by neural networks.

  14. Race to the Top. Ohio. State-Reported APR: Year One

    ERIC Educational Resources Information Center

    US Department of Education, 2012

    2012-01-01

    This paper describes Ohio's progress in implementing a comprehensive and coherent approach to education reform from the time of application through June 30, 2011. The sections presented in this report highlight key accomplishments made by Ohio to implement a comprehensive and coherent approach to education reform over the reporting period in the…

  15. Hybrid image processing; Proceedings of the Meeting, Orlando, FL, Apr. 1, 2, 1986

    SciTech Connect

    Casasent, D.P.; Tescher, A.

    1986-01-01

    The conference presents papers on optical pattern recognition; optical image processing, artificial intelligence, and synthetic discrimination functions; digital image processing; and hybrid image processing. Attention is given to multiple optical filter design simulation results, acoustooptic image correlators, texture classification using the Hough transform, iteratively designed optical correlation filters for distortion invariant recognition, and an instrument-induced spatial crosstalk deconvolution algorithm. Papers are also presented on infrared power spectral density diurnal variations and clutter rejection scaling laws for focal plane arrays, the use of complementary analog and digital processing in the removal of local background in low contrast images, and the construction of low noise correlation filters.

  16. Remote sensing of atmospheric chemistry; Proceedings of the Meeting, Orlando, FL, Apr. 1-3, 1991

    NASA Technical Reports Server (NTRS)

    Mcelroy, James L. (Editor); Mcneal, Robert J. (Editor)

    1991-01-01

    The present volume on remote sensing of atmospheric chemistry discusses special remote sensing space observations and field experiments to study chemical change in the atmosphere, network monitoring for detection of stratospheric chemical change, stratospheric chemistry studies, and the combining of model, in situ, and remote sensing in atmospheric chemistry. Attention is given to the measurement of tropospheric carbon monoxide using gas filter radiometers, long-path differential absorption measurements of tropospheric molecules, air quality monitoring with the differential optical absorption spectrometer, and a characterization of tropospheric methane through space-based remote sensing. Topics addressed include microwave limb sounder experiments for UARS and EOS, an overview of the spectroscopy of the atmosphere using an FIR emission experiment, the detection of stratospheric ozone trends by ground-based microwave observations, and a FIR Fabry-Perot spectrometer for OH measurements.

  17. The Lower Solar Atmosphere During the WHI Campaign (20 Apr-16 May 2008)

    NASA Technical Reports Server (NTRS)

    Sterling, Alphonse

    2009-01-01

    The Whole Heliospheric Interval (WHI) period of 20 March - 16 April had a "quiet side" of the Sun, and an "active side," with three ARs. At least two of the ARs produced CMEs, but there were several events that may have been "confined eruptions" from these regions too. Examining the magnetic environment of the erupting regions gives insight into the onset and dynamics of the eruptions. Several of the CMEs can be traced back to likely disk sources, but several unmatched cases still remain. More work is needed to sort through these points.

  18. Mathematical aspects of vortex dynamics; Proceedings of the Workshop, Leesburg, VA, Apr. 25-27, 1988

    SciTech Connect

    Caflisch, R.E.

    1989-01-01

    Various papers on the mathematical aspects of vortex dynamics are presented. Individual topics addressed include: mathematical analysis of vortex dynamics, improved vortex methods for three-dimensional flows, the relation between thin vortex layer and vortex sheets, computations of broadband instabilities in a class of closed-streamline flows, vortex-sheet dynamics and hyperfunction theory, free surface vortex method with weak viscous effects, iterative method for computing steady vortex flow systems, invariant measures for the two-dimensional Euler flow, similarity flows containing two-branched vortex sheets, strain-induced vortex stripping, convergence of the vortex method for vortex sheets, boundary conditions and deterministic vortex methods for the Navier-Stokes equations, vorticity creation boundary conditions, vortex dynamics of stratified flows, vortex breakdown, numerical studies of vortex reconnection, vortex lattices in theory and practice, dynamics of vortex structures in the wall region of a turbulent boundary layer, and energy of a vortex lattice configuration.

  19. Race to the Top. Rhode Island. State-Reported APR: Year One

    ERIC Educational Resources Information Center

    US Department of Education, 2012

    2012-01-01

    This paper describes Rhode Island's progress in implementing a comprehensive and coherent approach to education reform from the time of application through June 30, 2011. In particular, this report highlights key accomplishments over the reporting period in the four reform areas: standards and assessments, data systems to support instruction,…

  20. 15 CFR 782.1 - Overview of reporting requirements under the APR.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE ADDITIONAL PROTOCOL REGULATIONS GENERAL INFORMATION REGARDING REPORTING REQUIREMENTS AND PROCEDURES § 782.1 Overview of reporting... Annual Update Report, a No Changes Report, an Import Confirmation Report, a Supplemental...

  1. 15 CFR 782.1 - Overview of reporting requirements under the APR.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE ADDITIONAL PROTOCOL REGULATIONS GENERAL INFORMATION REGARDING REPORTING REQUIREMENTS AND PROCEDURES § 782.1 Overview of reporting... Annual Update Report, a No Changes Report, an Import Confirmation Report, a Supplemental...

  2. 15 CFR 782.1 - Overview of reporting requirements under the APR.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE ADDITIONAL PROTOCOL REGULATIONS GENERAL INFORMATION REGARDING REPORTING REQUIREMENTS AND PROCEDURES § 782.1 Overview of reporting... Annual Update Report, a No Changes Report, an Import Confirmation Report, a Supplemental...

  3. Novel optoelectronic devices; Proceedings of the Meeting, The Hague, Netherlands, Mar. 31-Apr. 2, 1987

    NASA Technical Reports Server (NTRS)

    Adams, Michael J. (Editor)

    1987-01-01

    The present conference on novel optoelectronics discusses topics in the state-of-the-art in this field in the Netherlands, quantum wells, integrated optics, nonlinear optical devices and fiber-optic-based devices, ultrafast optics, and nonlinear optics and optical bistability. Attention is given to the production of fiber-optics for telecommunications by means of PCVD, lifetime broadening in quantum wells, nonlinear multiple quantum well waveguide devices, tunable single-wavelength lasers, an Si integrated waveguiding polarimeter, and an electrooptic light modulator using long-range surface plasmons. Also discussed are backward-wave couplers and reflectors, a wavelength-selective all-fiber switching matrix, the impact of ultrafast optics in high-speed electronics, the physics of low energy optical switching, and all-optical logical elements for optical processing.

  4. Investigation of electron attachment in polyatomic molecules. Final report 1 Apr 77-31 Mar 80

    SciTech Connect

    Dowell, J.T.

    1980-05-30

    Electron attachment to polyatomic molecules was studied using molecular beams of variable temperature crossed with an electron of high energy resolution. Species investigated include sulfur hexafluoride, molybdenum hexafluoride, and tungsten oxide polymers. New results were obtained in sulfur hexafluoride demonstrating importance of internal energy for the dissociative attachment in molybdenum hexafluoride. Tungsten oxide vapor exhibits both monomer and dimer negative ion formation near zero energy, apparently from dissociative attachment to the trimer.

  5. Applications of artificial intelligence VI; Proceedings of the Meeting, Orlando, FL, Apr. 4-6, 1988

    SciTech Connect

    Trivedi, M.M.

    1988-01-01

    Papers are presented on architectures for AI applications, schemes for image understanding, knowledge-based systems, image segmentation and analysis, expert systems, and uncertainty management. Also considered are computational vision, syntactic learning, three-dimensional vision schemes involving shape recovery and analysis, computer vision models and applications, and parallel architectures. Other topics include path planning, robotic systems, target detection and image understanding, natural language systems, and knowledge acquisition and representation.

  6. Applications of artificial intelligence IX; Proceedings of the Meeting, Orlando, FL, Apr. 2-4, 1991

    SciTech Connect

    Trivedi, M.M.

    1991-01-01

    The present conference discusses expert systems, object-detection techniques, planning and scheduling, image-analysis methods, knowledge-based systems, robot vision systems, AI-based diagnosis methods, design environment and tools for intelligent robots, and mobile robots. Also discussed are intelligent robot architectures, machine/computer vision applications, knowledge-acquisition and knowledge-based system verification, three-dimensional robot vision, image modeling, synthesis, and evaluation, applications of neural networks, hardware architectures for AI, planning robotic tasks, the representation and machine comprehension of natural language, and 3D textured vision systems.

  7. Race to the Top. Maryland. State-Reported APR: Year One

    ERIC Educational Resources Information Center

    US Department of Education, 2012

    2012-01-01

    This paper describes Maryland's progress in implementing a comprehensive and coherent approach to education reform from the time of application through June 30, 2011. In particular, this report highlights key accomplishments over the reporting period in the four reform areas: standards and assessments, data systems to support instruction, great…

  8. APR1400 LBLOCA uncertainty quantification by Monte Carlo method and comparison with Wilks' formula

    SciTech Connect

    Hwang, M.; Bae, S.; Chung, B. D.

    2012-07-01

    An analysis of the uncertainty quantification for the PWR LBLOCA by the Monte Carlo calculation has been performed and compared with the tolerance level determined by Wilks' formula. The uncertainty range and distribution of each input parameter associated with the LBLOCA accident were determined by the PIRT results from the BEMUSE project. The Monte-Carlo method shows that the 95. percentile PCT value can be obtained reliably with a 95% confidence level using the Wilks' formula. The extra margin by the Wilks' formula over the true 95. percentile PCT by the Monte-Carlo method was rather large. Even using the 3 rd order formula, the calculated value using the Wilks' formula is nearly 100 K over the true value. It is shown that, with the ever increasing computational capability, the Monte-Carlo method is accessible for the nuclear power plant safety analysis within a realistic time frame. (authors)

  9. Advances in optical structure systems; Proceedings of the Meeting, Orlando, FL, Apr. 16-19, 1990

    NASA Astrophysics Data System (ADS)

    Breakwell, John; Genberg, Victor L.; Krumweide, Gary C.

    Various papers on advances in optical structure systems are presented. Individual topics addressed include: beam pathlength optimization, thermal stress in glass/metal bond with PR 1578 adhesive, structural and optical properties for typical solid mirror shapes, parametric study of spinning polygon mirror deformations, simulation of small structures-optics-controls system, spatial PSDs of optical structures due to random vibration, mountings for a four-meter glass mirror, fast-steering mirrors in optical control systems, adaptive state estimation for control of flexible structures, surface control techniques for large segmented mirrors, two-time-scale control designs for large flexible structures, closed-loop dynamic shape control of a flexible beam. Also discussed are: inertially referenced pointing for body-fixed payloads, sensor blending line-of-sight stabilization, controls/optics/structures simulation development, transfer functions for piezoelectric control of a flexible beam, active control experiments for large-optics vibration alleviation, composite structures for a large-optical test bed, graphite/epoxy composite mirror for beam-steering applications, composite structures for optical-mirror applications, thin carbon-fiber prepregs for dimensionally critical structures.

  10. 48 CFR 1552.235-79 - Release of contractor confidential business information (APR 1996).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... entitled to confidential treatment under existing Agency regulations (40 CFR part 2) may be included in the... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Release of contractor... Texts of Provisions and Clauses 1552.235-79 Release of contractor confidential business information...

  11. 48 CFR 1552.235-79 - Release of contractor confidential business information (APR 1996).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... entitled to confidential treatment under existing Agency regulations (40 CFR part 2) may be included in the... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Release of contractor... Texts of Provisions and Clauses 1552.235-79 Release of contractor confidential business information...

  12. Complexity theory of neural networks. Final technical report, 15 Sep-14 Apr 91

    SciTech Connect

    Berman, P.; Schnitger, G.; Parberry, I.

    1991-08-09

    Significant progress has been made in laying the foundations of a complexity theory of neural networks. The fundamental complexity classes have been identified and studied. The class of problems solvable by small, shallow neural networks has been found to be the same class even if (1) probabilistic behaviour (2)Multi-valued logic, and (3)analog behaviour, are allowed (subject to certain resonable technical assumptions). Neural networks can be made provably fault-tolerant by physically separating the summation units from the thresholding units. New results have also been obtained on the complexity of approximation, communication complexity, the complexity of learning from examples and counterexamples, learning with multi-valued neurons, exponential lower bounds for restricted neural networks, and fault tolerance in distributed computation.

  13. 48 CFR 1552.235-79 - Release of contractor confidential business information (APR 1996).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... entitled to confidential treatment under existing Agency regulations (40 CFR part 2) may be included in the.... 7401 et seq.); the Federal Water Pollution Control Act (33 U.S.C.1251 et seq.); the Safe Drinking Water... “Treatment of Confidential Business Information.”) Except where otherwise provided by law, the Agency...

  14. High temperature solar receiver. Final report, 7 Jun. 1979 - 7 Apr. 1981

    SciTech Connect

    Not Available

    1981-04-01

    The development of a high temperature solar thermal receiver is described. A prototype receiver and associated test support (auxiliary) hardware was fabricated. Shakedown and initial performance tests of the prototype receiver were performed. Maximum outlet temperatures of 1600 F were achieved at 100% solar (70-75 kW) input power with 900 F inlet temperatures and a subsequent testing was concluded by a 2550 F outlet run. The window retaining assembly was modified to improve its tolerance for thermal distortion of the flanges. It is shown that cost effective receiver designs can be implemented within the framework of present materials technology.

  15. CO2 laser frequency doubling. Final report, 24 Sep 91-24 Apr 92

    SciTech Connect

    Not Available

    1992-04-24

    This work addresses the possibility of a high average power coherent light source in the mid-infrared, specifically in the 4.8 micrometers atmospheric window. The approach is to frequency-double the 9.55 micrometers CO2 laser line, yielding 4.775 micrometers. In order to achieve efficient conversion, the intensity of the laser is increased by intracavity resonant modulation, or modelocking. The intensity for efficient conversion in typical available lengths of doubling material is at a minimum 20 MW sq.cm. However, the most efficient CO2 lasers operate with a pulse duration of at least 1 microsec, the characteristic time for energy transfer from N2 to CO2 at 1 atmosphere. Without modulation a fluence of at least 20 J sq.cm would therefore be needed for high overall system efficiency. With modulation at a 1:10 or better mark-to-space ratio, this fluence is reduced to the 2 J sq.cm range that typifies the surface damage threshold of available materials. One important unknown was the effect on damage threshold of a modulated versus an unmodulated pulse. Was the threshold dependent on peak intensity, or fluence. Other questions related to the specific material AgGaSe2, silver gallium selenide, chosen for this work. What was the quality of the second harmonic beam; what was the effective nonlinear coefficient; what was the temperature dependence of the phase-matching; and what was its thermal conductivity (to remove absorbed heat in an average power situation).

  16. Optically pumped metal vapor lasers. Final technical report, 15 Apr 1978-15 Jul 1980

    SciTech Connect

    Mandl, A.; Hyman, H.

    1980-09-01

    The properties of optically-excited Hg/NH/sub 3/ and Hg/ND/sub 3/ mixtures have been studied as a function of mercury pressure in the range 1 to 40 torr. At low mercury pressures, less than or equal to 1 torr, the well-known uv emission band due to HgNH/sub 3/* is dominant; this regime has been investigated extensively over the past ten years. However, at higher pressures the uv band disappears and is replaced by a strong green emission band, centered near 500 nm. From a detailed study of the spectral and temporal characteristics of the green band, it is concluded that it arises from the formation of the Hg/sub 2/NH/sub 3/* (or Hg/sub 2/ND/sub 3/*) excited molecular complex. The lifetime of this exciplex has been measured and is found to be 3.8 ..mu..sec (+- 25%). Because of interest in the system as a potential energy storage laser medium, optical transmission measurements have been carried out at selected wavelengths. Net absorption has been observed across the green band at high mercury density, as well as in the uv band in the low density regime.

  17. 15 CFR 781.2 - Purposes of the Additional Protocol and APR.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... and with physical access to reportable locations where nuclear facilities, materials, or ores are.... Declaration). The Additional Protocol is based upon and is virtually identical to the IAEA Model...

  18. Blytheville AFB, Arkansas. Water quality management survey. Final report 11-14 Apr 83

    SciTech Connect

    New, G.R.; Gibson, D.P. Jr.

    1983-05-01

    The USAF OEHL conducted an on site water quality management survey at Blytheville AFB. Main areas of interest were (1) the wastewater treatment plant effluent fecal coliform count, and residual chlorine content, and (2) the stream sampling protocol. The drinking water plant, landfill and industrial shops were also included in the survey. Results of the survey indicated that the low residual chlorine content caused high fecal coliform counts in the wastewater effluent. The chemical parameters sampled in the stream monitoring program did not coincide with the requirements of the State of Arkansas and required modification. Recommendations were made to increase the residual chlorine content of the wastewater effluent and to increase the mixing of the chlorine contact chamber. A list of the chemical parameters was included in the report for stream monitoring.

  19. Space Electrochemical Research and Technology Conference, 2nd, Cleveland, OH, Apr. 11-13, 1989, Proceedings

    NASA Technical Reports Server (NTRS)

    O'Donnell, Patricia M. (Editor)

    1990-01-01

    Attention is given to topics of advanced concepts, hydrogen-oxygen fuel cells and electrolyzers, nickel electrodes, and advanced rechargeable batteries. Papers are presented on human exploration mission studies, advanced rechargeable sodium batteries with novel cathodes, advanced double-layer capacitors, recent advances in solid-polymer electrolyte fuel cell technology with low platinum loading electrodes, electrocatalysts for oxygen electrodes in fuel cells and water electrolyzers for space applications, and the corrosion testing of candidates for the alkaline fuel cell cathode. Other papers are on a structural comparison of nickel electodes and precursor phases, the application of electrochemical impedance spectroscopy for characterizing the degradation of Ni(OH)2/NiOOH electrodes, advances in lightweight nickel electrode technology, multimission nickel-hydrogen battery cell for the 1990s, a sodium-sulfur battery flight experiment definition study, and advances in ambient-temperature secondary lithium cells.

  20. Race to the Top. Tennessee. State-Reported APR: Year One

    ERIC Educational Resources Information Center

    US Department of Education, 2012

    2012-01-01

    This paper describes Tennessee's progress in implementing a comprehensive and coherent approach to education reform from the time of application through June 30, 2011. In particular, this report highlights key accomplishments over the reporting period in the four reform areas: standards and assessments, data systems to support instruction, great…

  1. Race to the Top. District of Columbia. State-Reported APR: Year One

    ERIC Educational Resources Information Center

    US Department of Education, 2012

    2012-01-01

    This paper describes the District of Columbia's progress in implementing a comprehensive and coherent approach to education reform from the time of application through June 30, 2011. In particular, this report highlights key accomplishments over the reporting period in the four reform areas: standards and assessments, data systems to support…

  2. Time-dependent gravity in southern California, May 1974 - Apr 1979

    NASA Technical Reports Server (NTRS)

    Whitcomb, J. H.; Franzen, W. O.; Given, J. W.; Pechman, J. C.; Ruff, L. J.

    1979-01-01

    Gravity measurements were coordinated with the long baseline three dimensional geodetic measurements of the Astronomical Radio Interferometric Earth Surveying project which used radio interferometry with extra-galactic radio sources. Gravity data from 28 of the stations had a single reading standard deviation of 11 microgal which gives a relative single determination between stations a standard deviation of 16 microgal. The largest gravity variation observed, 80 microgal, correlated with nearby waterwell variations and with smoothed rainfall. Smoothed rainfall data appeared to be a good indicator of the qualitative response of gravity to changing groundwater levels at other suprasediment stations, but frequent measurement of gravity at a station was essential until the quantitative calibration of the station's response to groundwater variations was accomplished.

  3. Infrared readout electronics; Proceedings of the Meeting, Orlando, FL, Apr. 21, 22, 1992

    NASA Astrophysics Data System (ADS)

    Fossum, Eric R.

    The present volume on IR readout electronics discusses cryogenic readout using silicon devices, cryogenic readout using III-V and LTS devices, multiplexers for higher temperatures, and focal-plane signal processing electronics. Attention is given to the optimization of cryogenic CMOS processes for sub-10-K applications, cryogenic measurements of aerojet GaAs n-JFETs, inP-based heterostructure device technology for ultracold readout applications, and a three-terminal semiconductor-superconductor transimpedance amplifier. Topics addressed include unfulfilled needs in IR astronomy focal-plane readout electronics, IR readout integrated circuit technology for tactical missile systems, and radiation-hardened 10-bit A/D for FPA signal processing. Also discussed are the implementation of a noise reduction circuit for spaceflight IR spectrometers, a real-time processor for staring receivers, and a fiber-optic link design for INMOS transputers.

  4. Applications of artificial intelligence III; Proceedings of the Meeting, Orlando, FL, Apr. 1-3, 1986

    SciTech Connect

    Gilmore, J.F.

    1986-01-01

    Papers are presented on expert systems for such functions as model management, the labeling segment in FLIR imagery, and on-board fault monitoring and diagnosis; procedures for analyzing and interpreting images; and knowledge-based systems for planning, ship identification, fault-identification systems, design issues, interpretation of signal images, and electronic circuit-diagram interpretation. Topics discussed include image procesing, heuristic systems, and knowledge presentation. Consideration is given to pattern recognition, robotics, and a number of artificial intelligence applications.

  5. Design of optical instruments; Proceedings of the Meeting, Orlando, FL, Apr. 22-24, 1992

    NASA Astrophysics Data System (ADS)

    Aikens, David M.; Genberg, Victor L.; Krumweide, Gary C.; Thomas, Michael J.

    1992-09-01

    Topics discussed in this volume include optical system design, recent application of composite materials to precision optical instrument structure, development of composite mirrors and reflectos, development of composite materials for dimensionally stable structures, and structural mechanics. Papers are presented on adjustable distortion correctors, the optical design for the ATLAS multispectral scanner, an internal thermal emission analysis of an IR seeker, recent developments with the Mars Observer Camera graphite/epoxy structure, and moisture effects and control for the Ultraviolet Coronagraph Spectrograph composite structure. Attention is also given to composite materials for precision space reflector panels, the structural design and analysis for an ultralow-CTE optical bench for the Hubbale Space Telescope corrective optics, the evaluation of high-modulus pitch/cyanate material systems for dimensionally stable structures, weight minimization of an active mirror, and a compliant optical mount design. (For individual items see A93-29782 to A93-29798)

  6. Atmospheric processes in reaction of Northern Sumatra Earthquake sequence Dec 2004-Apr 2005

    NASA Astrophysics Data System (ADS)

    Ouzounov, D.; Pulinets, S.; Cervone, G.; Singh, R.; Taylor, P.

    2005-05-01

    This work describes our first results in analyzing data from different and independent sources ûemitted long-wavelength radiation (OLR), surface latent heat flux (SHLF) and GPS Total Electron Content (TEC) collected from ground based (GPS) and satellite TIR (thermal infra-red) data sources (NOAA/AVHRR, MODIS). We found atmosphere and ionosphere anomalies one week prior to both the Sumatra-Andaman Islands earthquake (Dec 26, 2004) and M 8.7 - Northern Sumatra, March 28, 2005. We analyzed 118 days of data from December 1, 2004 through April 1, 2005 for the area (0°-10°,north latitude and 90°-100° east longitude) which included 125 earthquakes with M>5.5. Recent analysis of the continuous OLR from the Earth surface indicates anomalous variations (on top of the atmosphere) prior to a number of medium to large earthquakes. In the case of M 9.0 - Sumatra-Andaman Islands event, compared to the reference fields for the months of December between 2001 and 2004, we found strongly OLR anomalous +80 W/m2 signals (two sigma) along the epicentral area on Dec 21, 2004 five days before the event. In the case of M8.7 March 28, 2005 anomalues signatures over the epicenter appears on March 26 is much weaker (only +20W/m2) and have a different topology. Anomalous values of SHLF associated with M9.0 - Sumatra-Andaman Islands were found on Dec 22, 2005 (SLHF +280Wm2) and less intensity on Mar 23, 2005 (SLHF +180Wm2). Ionospheric variations (GPS/TEC) associated with the Northern Sumatra events were determine by five Regional GPS network stations (COCO, BAKO, NTUS, HYDE and BAST2). For every station time series of the vertical TEC (VTEC) were computed together with correlation with the Dst index. On December 22, four days prior to the M9.0 quake GPS/TEC data reach the monthly maximum for COCO with minor DST activity. For the M 8.7-March 28 event, the increased values of GPS/TEC were observed during four days (March 22-25) in quiet geomagnetic background. Our results need additional validation and the could be explained within the framework of a model of Lithosphere-Atmosphere-Ionosphere coupling, supporting the hypothesis of a relationship between a thermodynamic processes produced by increasing tectonic stresses in the Earth's crust and attendant electro-chemical interactions between the crust and the atmosphere/ionosphere.

  7. Remote sensing of the biosphere; Proceedings of the Meeting, Orlando, FL, Apr. 19, 20, 1990

    NASA Technical Reports Server (NTRS)

    Smith, James A. (Editor)

    1990-01-01

    The global context and monitoring of the biological aspects relevant to the EOS program are addressed, the large-scale regional field experiments required to understand ecosystem functioning in more detail and to calibrate the application of remote-sensing techniques for extracting flux and state information are covered, and sensors of the proposed EOS platform are discussed. Attention is given to terrestrial productivity, both tropical-forest and semiarid environments, coastal environments, and global oceanic productivity. Focus is placed on the First International Field Experiment (FIFE) in Kansas, the HAPEX field experiment in France, the ABLE-2 experiment in the Amazon, and the Forest Ecosystem Study in Maine. The proposed electro-optical instruments for EOS including both MODIS-N and MODIS-T, the AIRS and MISR instruments, the ITIR, and ERBE calibration issues are considered.

  8. Race to the Top. North Carolina. State-Reported APR: Year One

    ERIC Educational Resources Information Center

    US Department of Education, 2012

    2012-01-01

    This paper describes the State's progress in implementing a comprehensive and coherent approach to education reform from the time of application through June 30, 2011. In particular, this report highlights key accomplishments over the reporting period in the four reform areas: standards and assessments, data systems to support instruction, great…

  9. Acquisition, tracking, and pointing IV; Proceedings of the Meeting, Orlando, FL, Apr. 19, 20, 1990

    SciTech Connect

    Gowrinathan, S.

    1990-01-01

    Various papers on acquisition, tracking, and pointing are presented. Individual topics addressed include: backlash control techniques in geared servo mechanics; optical fiber and photodetector array for robotic seam tracking; star trackers for spacecraft applications; Starfire optical range tracking system for the 1.5 m telescope; real-time video image centroid tracker; optical alignment with a beamwalk system; line-of-sight stabilization requirements for target tracking system; image quality with narrow beam illumination in an active tracking system; IR sensor data fusion for target detection, identification, and tracking; target location and pointing algorithm for a three-axis stabilized line scanner. Also discussed are: adaptive control system techniques applied to inertial stabilization systems; supervisory control of electrooptic tracking and pointing; position loop compensation for flex-pivot-mounted gimbal stabilization systems; advanced testing methods for acquisition, tracking, and pointing; development of kinmatics for gimballed mirror systems.

  10. Remote sensing; Proceedings of the Meeting, Orlando, FL, Apr. 3, 4, 1986

    NASA Technical Reports Server (NTRS)

    Menzies, Robert T. (Editor)

    1986-01-01

    Advances in optical technology for remote sensing are discussed in reviews and reports of recent experimental investigations. Topics examined include industrial applications, laser diagnostics for combustion research, laser remote sensing for ranging and altimetry, and imaging systems for terrestrial remote sensing from space. Consideration is given to LIF in forensic diagnostics, time-resolved laser-induced-breakdown spectrometry for rapid analysis of alloys, CARS in practical combustion environments, airborne inertial surveying using laser tracking and profiling techniques, earth-resources instrumentation for the EOS polar platform of the Space Station, and the SAR for EOS.

  11. Investigation of laser-induced retinal damage. Annual report, 1 Apr 91-31 Mar 92

    SciTech Connect

    Glickman, R.D.; Lam, K.W.

    1992-04-22

    Laser-induced, photooxidative damage in ocular tissue was studied with a quantitative assay using high performance liquid chromatography (HPLC) to separate oxidized and reduced ascorbic acid in exposed tissue components. We demonstrated that ascorbic acid, incubated with whole, bovine retinal pigment epithelial (RPE) cells, was oxidized when the reaction mixture was exposed to the output of an argon-ion continuous wave laser The amount of ascorbic acid oxidized was proportional to the irradiance of the sample, and the reaction was wavelength-dependent, with short-wavelength visible light more effective than long-wavelengths in driving the, reaction. The photosensitizing activity was associated with the RPE melanin pigment granules, and was not lost after disrupting or heating the RPE cells. Because melanin was known to form free radicals when illuminated, we hypothesized that ascorbic acid detoxified the light-activated melanin free radicals while being itself oxidized in process. If the supply of reduced ascorbic acid were exhausted, however, the activated melanin could have been the source of tissue-damaging radicals. This model was consistent with a photochemical damage mechanism involving light-activated melanin.

  12. Small satellite technologies and applications II; Proceedings of the Meeting, Orlando, FL, Apr. 21, 22, 1992

    NASA Astrophysics Data System (ADS)

    Horais, Brian J.

    The present conference on small satellite (SS) systems and their supporting technologies discusses the Medsat SS for malaria early warning and control, results of the Uosat earth-imaging system, commercial applications for MSSs, an SS family for LEO communications, videosignal signature-synthesis for fast narrow-bandwidth transmission, and NiH battery applications in SSs. Also discussed are the 'PegaStar' spacecraft concept for remote sensing, dual-cone scanning earth sensor processing algorithms, SS radiation-budget instrumentation, SDI's relevance to SSs, spacecraft fabrication and test integration, and cryocooler producibility. (For individual items see A93-28077 to A93-28100)

  13. Apres le Deluge at State U: A Comprehensive Public University Responds to the Great Recession

    ERIC Educational Resources Information Center

    Skinner, Richard A.; Miller, Emily R.

    2013-01-01

    In this article, the authors describe one institution--East Carolina University--that they think is representative of an important type and a large proportion of American universities, the comprehensive public university, and its responses to the lingering Great Recession. As a group, comprehensives handle almost 40 per cent of the total student…

  14. Race to the Top. Delaware. State-Reported APR: Year One

    ERIC Educational Resources Information Center

    US Department of Education, 2012

    2012-01-01

    This paper describes Delaware's progress in implementing a comprehensive and coherent approach to education reform from the time of application through June 30, 2011. In particular, it highlights key accomplishments over the reporting period in the four reform areas: standards and assessments, data systems to support instruction, great teachers…

  15. Energy-conserving coating - pigment research. Final report, Sep 88-Apr 91

    SciTech Connect

    Novinson, T.

    1991-05-01

    This report documents research into novel experimental paints made from color-reversible pigments. These pigments are of two types: Photochromic and thermochromic. The first group changes color on exposure to light, and the second changes color when subjected to a change in temperature. If successfully incorporated into a coating and applied to walls and roofs, these pigments could reduce heating and cooling costs by presenting a more absorbent color in the winter and a more reflective color in the summer.

  16. AIAA Dynamics Specialists Conference, Dallas, TX, Apr. 16, 17, 1992, Technical Papers

    SciTech Connect

    Not Available

    1992-01-01

    This conference presents papers in the fields of spacecraft dynamics, the control of structures, the active flexible wing, flutter characteristics, and rotary-wing aeroelasticity. Also considered are control-structure interaction, unsteady aerodynamics, fixed-wing aeroelasticity, structural dynamics systems, and CSI-sensors and actuators.

  17. Mobile system for extracting spilled hazardous materials from excavated soils. Final report Dec 76-Apr 82

    SciTech Connect

    Scholz, R.; Milanowski, J.

    1983-10-01

    Laboratory tests were conducted with three separate pollutants (phenol, arsenic trioxide, and polychlorinated biphenyls (PCB's) and two soils of widely different characteristics (sand/gravel/silt/clay and organic loam) to evaluate techniques for cleansing soil contaminated with released or spilled hazardous materials. The tests show that scrubbing of excavated soil on site is an efficient approach for freeing soils of certain contaminants but that the effectiveness depends on the washing fluid (water + additives) and on the soil composition and particle size distribution. Based on the test results, a full-scale, field-use system was designed, engineered, fabricated, assembled, and briefly tested; the unit is now ready for field demonstrations.

  18. 1993 Aerospace Avionic Systems Division Conference, 3rd, Denver, CO, Apr. 22, 1993, Proceedings

    NASA Astrophysics Data System (ADS)

    Topics addressed include a single-supply monolithic, MIL-STD-1553 transreceiver implemented in BiCMOS wafer fabrication technology, a development methodology for contemporary avionics systems, MIL-STD-1553 remote terminal design using ASIC megacell technology, a modular electrooptic bus coupler, experiences in validating MIL-STD-1553 remote terminals, and the STANAG 3910 data bus for the next generation of European avionics systems. Attention is also given to JIAWG compatible development boards for the i960, high-speed databus evaluation, the space avionics architecture standard tailored to the common lunar lander conceptual design, and 1553 RT mechanizations for data sample consistency and multimessage transfers.

  19. Analysis of Parent Survey Data Addressing Part B SPP/APR Indicator #8--2012

    ERIC Educational Resources Information Center

    Penfield, Randall D.

    2012-01-01

    In accordance with federal reporting requirements mandated by the U.S. Department of Education, Office of Special Education Programs (OSEP) under the Individuals with Disabilities Education Act, the Bureau of Indian Education (BIE) must report annually on 20 performance indicators related to the provision of special education services to children…

  20. Space Congress, 29th, Cocoa Beach, FL, Apr. 21-24, 1992, Proceedings

    NASA Astrophysics Data System (ADS)

    The present volume on the quest for new frontiers in space discusses weather impacts on space operations, planning for the performance of future space bases, a new guidance and control unit for the Titan IV vehicle, and nondestructive evaluation of Shuttle Columbia tiles. Attention is given to Space Shuttle payload accommodations and trends in customer demands, a generic propellants transfer unit, making space part of general education, space station on-orbit solar array loads during assembly, and dimensional stability of the attitude reference assembly on SSF. Topics addressed include National Launch System payload accommodations and launch operations, the integrated factory/launch site processing concept, Pioneer 10 interstellar studies, and the role of advanced nuclear propulsion systems in precursor interstellar missions. Also discussed are legal challenges in realizing interstellar initiatives, Mars transportation system synthesis, and NASA's commercial space program. (For individual items see A93-25277 to A93-25313)

  1. Space Congress, 28th, Cocoa Beach, FL, Apr. 23-26, 1991, Proceedings

    NASA Astrophysics Data System (ADS)

    1991-11-01

    The present conference on aerospace developments and issues encompasses interstellar and space-exploration initiatives, commercial space development, science payloads, space shuttle derivatives, space education, and Space Station activities. Specific issues addressed include magnetic shielding for interplanetary spacecraft, a launch-site comparison between the earth, moon, and Mars, the Spacehab approach, commercial infrastructure participation in the Space Station Freedom (SSF), the science uses of tethered satellites in low planetary orbits, and enabling life-sciences research on the SSF. Also addressed are simulations of shuttle and derivative-vehicle processing, daily operations that support the Global Positioning System, the utilization of common pressured modules on the SSF, the development of ground- and space-based laser systems, the crisis in human capital, and the automated servicing of scientific payloads aboard orbiting laboratories.

  2. Race to the Top. Hawaii. State-Reported APR: Year One

    ERIC Educational Resources Information Center

    US Department of Education, 2012

    2012-01-01

    This paper describes Hawaii's progress in implementing a comprehensive and coherent approach to education reform from the time of application through June 30, 2011. In particular, it highlights key accomplishments over the reporting period in the four reform areas: standards and assessments, data systems to support instruction, great teachers and…

  3. GOES Animation of the Tornadoes from Apr. 27-28, 2014

    NASA Video Gallery

    This animation of NOAA's GOES-East satellite data shows the development and movement of the weather system that spawned tornadoes affecting seven central and southern U.S. states on April 27-28, 20...

  4. Space Congress, 24th, Cocoa Beach, FL, Apr. 21-24, 1987, Proceedings

    SciTech Connect

    Not Available

    1987-01-01

    Topics covered include space colonization, European technology development, expendable launch vehicles in the USA and Europe, Space Station technologies, Space Station servicing, and Columbus and Eureca. Consideration is also given to second generation STS/launch vehicle technology, computers, contracts and management, and technology spinoffs.

  5. Space Congress, 26th, Cocoa Beach, FL, Apr. 25-28, 1989, Proceedings

    SciTech Connect

    Not Available

    1989-01-01

    The papers presented in this volume provide an overview of new programs in space research, including a new beginning for the manned space flight, a rebirth of expendable vehicles, and commercialization of space exploration. Topics discussed include the next generation of STS, national space programs, space enterprise development, commercial space transportation, technology benefits, and the international aspect of Space Station. Attention is also given to state initiatives in space, launch responsiveness, offshore space launch developments, and Shuttle and Space Station scientific payloads and their role in the next generation.

  6. Space Congress, 28th, Cocoa Beach, FL, Apr. 23-26, 1991, Proceedings

    SciTech Connect

    Not Available

    1991-01-01

    The present conference on aerospace developments and issues encompasses interstellar and space-exploration initiatives, commercial space development, science payloads, space shuttle derivatives, space education, and Space Station activities. Specific issues addressed include magnetic shielding for interplanetary spacecraft, a launch-site comparison between the earth, moon, and Mars, the Spacehab approach, commercial infrastructure participation in the Space Station Freedom (SSF), the science uses of tethered satellites in low planetary orbits, and enabling life-sciences research on the SSF. Also addressed are simulations of shuttle and derivative-vehicle processing, daily operations that support the Global Positioning System, the utilization of common pressured modules on the SSF, the development of ground- and space-based laser systems, the crisis in human capital, and the automated servicing of scientific payloads aboard orbiting laboratories.

  7. Space Congress, 25th, Cocoa Beach, FL, Apr. 26-29, 1988, Proceedings

    SciTech Connect

    Not Available

    1988-01-01

    Papers are presented dealing with commercial aspects of space, space business, robotics, space station technologies, artificial intelligence applications in space, lunar and Mars exploration concepts, launch vehicles, and systems automation. Topics covered include ground processing of experiments conducted in space, the development of a commercial expendable launch vehicle industry, a small LEO satellite bus, epitaxial thin film growth in space, development of space enterprise, negotiating governmental contracts, robots in Shuttle hardware, telerobotic Space Station applications, simulation of an articulated transporter/manipulator system, welding the Space Station common module prototype, modeling the environment of the Man Tended Free Flyer, and Space Station rapid sample return. Ground operations support by AI, expert system prototype developments, Mars mission profile options and opportunities, launch vehicle operations analyses, space launch systems resiliency, model-based reasoning for knowledge-based software project management, technology advances for Space Shuttle processing, real-time fault management for large-scale systems, information systems for Shuttle processing, orbiter maneuvering vehicle support to the Space Station, and hydrogen-air-steam combustion regimes in large volumes are also discussed.

  8. Space Congress, 27th, Cocoa Beach, FL, Apr. 24-27, 1990, Proceedings

    SciTech Connect

    Not Available

    1990-01-01

    The present symposium on aeronautics and space encompasses DOD research and development, science payloads, small microgravity carriers, the Space Station, technology payloads and robotics, commercial initiatives, STS derivatives, space exploration, and DOD space operations. Specific issues addressed include the use of AI to meet space requirements, the Astronauts Laboratory Smart Structures/Skins Program, the Advanced Liquid Feed Experiment, an overview of the Spacelab program, the Autonomous Microgravity Industrial Carrier Initiative, and the Space Station requirements and transportation options for a lunar outpost. Also addressed are a sensor-data display for telerobotic systems, the Pegasus and Taurus launch vehicles, evolutionary transportation concepts, the upgrade of the Space Shuttle avionics, space education, orbiting security sentinels, and technologies for improving launch-vehicle responsiveness.

  9. Evaluation of longwall dust sources. Open file report 15 Sep 80-15 Apr 83

    SciTech Connect

    Ludlow, J.; Marshall, E.

    1983-04-01

    The major objective of this study was to define the relative contributions of various sources of respirable airborne dust on longwall faces. In order to define the contribution of various primary sources, continuous dust level data were recorded on five longwalls for an average of five shifts at each. By analysis of these data with records of face activity, it was possible to determine the overall contribution of each of the major elements of the longwall system to overall respirable dust exposure at various face locations. Average levels were determined for roof support generated dust, conveyor and intake dust, and for dust levels during various shearer activities. When average levels are compared between mines, a significant degree of consistency is noted. Another objective of the study was to differentiate the various dust sources associated with the shearer.

  10. Small-satellite technology and applications; Proceedings of the Meeting, Orlando, FL, Apr. 4, 5, 1991

    NASA Astrophysics Data System (ADS)

    Horais, Brian J.

    Remote sensing applications and systems, small satellites for sensing missions, and supporting technologies are the broad topics discussed. Particular papers are presented on small satellites for water cycle experiments, low-cost spacecraft buses for remote sensing applications, Webersat (a low-cost imaging satellite), DARPA initiatives in small-satellite technologies, a solid-state magnetic azimuth sensor for small satellites, and thermal analysis of a small expendable tether satellite package. (For individual items see A93-24152 to A93-24175)

  11. Race to the Top. Georgia. State-Reported APR: Year One

    ERIC Educational Resources Information Center

    US Department of Education, 2012

    2012-01-01

    This paper describe Georgia's progress in implementing a comprehensive and coherent approach to education reform from the time of application through June 30, 2011. In particular, it highlights key accomplishments over the reporting period in the four reform areas: standards and assessments, data systems to support instruction, great teachers and…

  12. Race to the Top. New York. State-Reported APR: Year One

    ERIC Educational Resources Information Center

    US Department of Education, 2012

    2012-01-01

    This paper describes New York's progress in implementing a comprehensive and coherent approach to education reform from the time of application through June 30, 2011. In particular, this report highlights key accomplishments over the reporting period in the four reform areas: standards and assessments, data systems to support instruction, great…

  13. LANL Water Protection Status Report - FY12 3rd Qtr. (Apr thru Jun 2012)

    SciTech Connect

    Douglass, Craig R.

    2012-07-12

    Continued monitoring of the Buckman Direct Diversion and Los Alamos County Water Supply Wells; Groundwater Protection - Continued implementation of the Interim Facility-Wide Groundwater Monitoring Plan (IFGMP); Surface Water Protection - Continued protection of surface water through implementation of the Individual Stormwater Permit (IP); Buckman Early Notification System operability at 100% per MOU Requirements.

  14. Hawaii. State Supplement. The 10th Annual AP[R] Report to the Nation

    ERIC Educational Resources Information Center

    College Board, 2014

    2014-01-01

    This report provides educators and policymakers with information they can use to celebrate their successes, understand their unique challenges, and set meaningful goals to increase opportunity for all students. It is important to note that while AP® Exams are valid measures of students' content mastery of college-level studies in specific academic…

  15. Alabama. State Supplement. The 10th Annual AP[R] Report to the Nation

    ERIC Educational Resources Information Center

    College Board, 2014

    2014-01-01

    This report provides educators and policymakers with information they can use to celebrate their successes, understand their unique challenges, and set meaningful goals to increase opportunity for all students. It is important to note that while AP® Exams are valid measures of students' content mastery of college-level studies in specific academic…

  16. Arizona. State Supplement. The 10th Annual AP[R] Report to the Nation

    ERIC Educational Resources Information Center

    College Board, 2014

    2014-01-01

    This report provides educators and policymakers with information they can use to celebrate their successes, understand their unique challenges, and set meaningful goals to increase opportunity for all students. It is important to note that while AP® Exams are valid measures of students' content mastery of college-level studies in specific academic…

  17. Colorado. State Supplement. The 10th Annual AP[R] Report to the Nation

    ERIC Educational Resources Information Center

    College Board, 2014

    2014-01-01

    This report provides educators and policymakers with information they can use to celebrate their successes, understand their unique challenges, and set meaningful goals to increase opportunity for all students. It is important to note that while AP® Exams are valid measures of students' content mastery of college-level studies in specific academic…

  18. The 8th Annual AP[R] Report to the Nation

    ERIC Educational Resources Information Center

    College Board, 2012

    2012-01-01

    In classrooms around the country, AP (Advanced Placement) teachers are preparing students for tomorrow by teaching them how to think and learn today. AP students learn to construct solid arguments, test theories, and see many sides of an issue--the kind of thinking that solves tough problems both in and outside the classroom, in college and…

  19. Maine. State Supplement. The 10th Annual AP[R] Report to the Nation

    ERIC Educational Resources Information Center

    College Board, 2014

    2014-01-01

    This report provides educators and policymakers with information they can use to celebrate their successes, understand their unique challenges, and set meaningful goals to increase opportunity for all students. It is important to note that while AP® Exams are valid measures of students' content mastery of college-level studies in specific academic…

  20. Delaware. State Supplement. The 10th Annual AP[R] Report to the Nation

    ERIC Educational Resources Information Center

    College Board, 2014

    2014-01-01

    This report provides educators and policymakers with information they can use to celebrate their successes, understand their unique challenges, and set meaningful goals to increase opportunity for all students. It is important to note that while AP® Exams are valid measures of students' content mastery of college-level studies in specific academic…

  1. Kansas. State Supplement. The 10th Annual AP[R] Report to the Nation

    ERIC Educational Resources Information Center

    College Board, 2014

    2014-01-01

    This report provides educators and policymakers with information they can use to celebrate their successes, understand their unique challenges, and set meaningful goals to increase opportunity for all students. It is important to note that while AP® Exams are valid measures of students' content mastery of college-level studies in specific academic…

  2. Alaska. State Supplement. The 10th Annual AP[R] Report to the Nation

    ERIC Educational Resources Information Center

    College Board, 2014

    2014-01-01

    This report provides educators and policymakers with information they can use to celebrate their successes, understand their unique challenges, and set meaningful goals to increase opportunity for all students. It is important to note that while AP® Exams are valid measures of students' content mastery of college-level studies in specific academic…

  3. Connecticut. State Supplement. The 10th Annual AP[R] Report to the Nation

    ERIC Educational Resources Information Center

    College Board, 2014

    2014-01-01

    This report provides educators and policymakers with information they can use to celebrate their successes, understand their unique challenges, and set meaningful goals to increase opportunity for all students. It is important to note that while AP® Exams are valid measures of students' content mastery of college-level studies in specific academic…

  4. Symposium on Electromagnetic Launcher Technology, 5th, Sandestin, FL, Apr. 3-5, 1990, Proceedings

    NASA Astrophysics Data System (ADS)

    Gooden, Clarence E.

    1991-01-01

    The present conference on electromagnetic accelerators (EMAs) and railguns (RGs) discusses active-current management for four-rail RGs, the design of a compulsator-drive 60-caliber RG, EMA studies with augmented rails, muzzle-shunt augmentation of conventional RGs, effect of in-bore gas on RG performance, the distributed-energy store RG, plasma diagnostics for high power ignitron development, a review of EMA armature research, RG hybrid armatures, a new solid-armature design concept, and the electrodynamics of RG plasma armatures. Also discussed is RG modeling at speed using three-dimensional finite elements, power supply technology for EMAs, rotating machine power supplies for next-generation EMAs, advanced EMA power supplies with magnetic-flux compression, metal-to-metal switches for large currents, lightweight high-effiency energy-storage transformers, hypervelocity projectile development for EMAs, structural design issues for EMA projectiles, stiff RGs, a reinforced Al conductor for cryogenic applications, mass-stabilized projectile designs for EMA launch, indictively-commutated coilguns, an actively switched pulsed induction accelerator, a plasma gun-augmented electrothermal accelerator, a symmetrical rail accelerator, and a travelling-wave synchronous coil gun.

  5. 78 FR 2684 - Notice of Proposed Information Collection for Public Comment: Annual Progress Report (APR) for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-14

    ... URBAN DEVELOPMENT Notice of Proposed Information Collection for Public Comment: Annual Progress Report... Community Planning and Development, U.S. Department of Housing and Urban Development (HUD). ACTION: Notice... Urban Development, 451 7th Street SW., Room 4160, Washington, DC 20410-5000; telephone (202)...

  6. Infrared optical materials VI; Proceedings of the Meeting, Orlando, FL, Apr. 4, 5, 1988

    NASA Astrophysics Data System (ADS)

    Musikant, Solomon

    1988-01-01

    Recent advances in IR optics are discussed in reviews and reports. Topics addressed include IR sensors and mirrors, IR-transmitting ceramics, IR waveguides, and IR glasses. Consideration is given to in situ visualization of the solid-liquid interface during crystal growth, (HgZn)Te IR photovoltaic detectors, lanthana-strengthened yttria IR-transmitting materials, high-temperature transmission measurements of IR window materials, fabrication of heavy-metal-fluoride glass fibers containing ultralow amounts of oxygen and water, and the material properties required for hollow fibers transmitting high-power IR radiation.

  7. Applications of artificial intelligence VIII; Proceedings of the Meeting, Orlando, FL, Apr. 17-19, 1990

    SciTech Connect

    Trivedi, M.M.

    1990-01-01

    The present conference on applications of artificial intelligence (AI) encompasses computer vision, knowledge acquisition and representation, model-based vision, neural networks, robot planning, knowledge-based systems, path planning, image analysis, AI in aerospace systems, and semiconductor manufacturing systems. Specific issues addressed include object detection using scale space, nonmonotonic scene interpretation, 3D object reconstruction from multiple stereo views, recognition via alignment using aspect models, target detection in a neural-network environment, the optimization of precedence-constraint robot assembly sequences, and free-space representations for robot-path planning. Also addressed are an edge-detection method, an approach to elemental task learning, issues in building intelligent grasping systems, an oral task-oriented dialogue for air-traffic controller training, and the experimental optimization of the neuronlike network applied for the processing of moving images.

  8. Properties of supported metal catalysts. Progress report, 1 Apr 1980-1 March 1981

    SciTech Connect

    Butt, J. B.; Burwell, Jr, R. L.; Cohen, J. B.

    1981-03-01

    The set of Pd/SiO/sub 2/ catalysts described in Report COO-4254-3 has been further characterized by in-situ, controlled atmosphere x-ray diffraction studies. In-situ reaction studies have also been conducted for methylcyclopropane hydrogenolysis and the formation of palladium hydride has been detected for the first time during a catalytic reaction. Isotopic exchange between cyclopentane and deuterium has been investigated for the series. This reaction is structure sensitive with the turnover number increasing monotonically with percentage metal exposed. Selectivity for exchange is also structure sensitive, with the ratio of d/sub 10//d/sub 5/ steadily declining with increasing percentage exposed. Similar behavior has been found for the hydrogenation of propylene, although the patterns of structure sensitivity differ. The mean square amplitude of vibration of the Pt atoms (measured with x-rays) has been obtained in situ in different gas environments; it has been found to increase with increasing temperature of H/sub 2/ reduction during pretreatment. For low percent Pt exposed in these catalysts, it was found that Pt changes form with increasing temperature of hydrogen reduction during pretreatment. The volume fraction determined from the area of the diffraction peak decreases appreciably. An examination of the Pt fluourescent x-rays however, shows that the Pt is still present.

  9. Space Electrochemical Research and Technology Conference, 2nd, Cleveland, OH, Apr. 11-13, 1989, Proceedings

    NASA Astrophysics Data System (ADS)

    O'Donnell, Patricia M.

    1990-02-01

    Attention is given to topics of advanced concepts, hydrogen-oxygen fuel cells and electrolyzers, nickel electrodes, and advanced rechargeable batteries. Papers are presented on human exploration mission studies, advanced rechargeable sodium batteries with novel cathodes, advanced double-layer capacitors, recent advances in solid-polymer electrolyte fuel cell technology with low platinum loading electrodes, electrocatalysts for oxygen electrodes in fuel cells and water electrolyzers for space applications, and the corrosion testing of candidates for the alkaline fuel cell cathode. Other papers are on a structural comparison of nickel electodes and precursor phases, the application of electrochemical impedance spectroscopy for characterizing the degradation of Ni(OH)2/NiOOH electrodes, advances in lightweight nickel electrode technology, multimission nickel-hydrogen battery cell for the 1990s, a sodium-sulfur battery flight experiment definition study, and advances in ambient-temperature secondary lithium cells.

  10. Visual information processing; Proceedings of the Meeting, Orlando, FL, Apr. 20-22, 1992

    NASA Technical Reports Server (NTRS)

    Huck, Friedrich O. (Editor); Juday, Richard D. (Editor)

    1992-01-01

    Topics discussed in these proceedings include nonlinear processing and communications; feature extraction and recognition; image gathering, interpolation, and restoration; image coding; and wavelet transform. Papers are presented on noise reduction for signals from nonlinear systems; driving nonlinear systems with chaotic signals; edge detection and image segmentation of space scenes using fractal analyses; a vision system for telerobotic operation; a fidelity analysis of image gathering, interpolation, and restoration; restoration of images degraded by motion; and information, entropy, and fidelity in visual communication. Attention is also given to image coding methods and their assessment, hybrid JPEG/recursive block coding of images, modified wavelets that accommodate causality, modified wavelet transform for unbiased frequency representation, and continuous wavelet transform of one-dimensional signals by Fourier filtering.

  11. Visual information processing II; Proceedings of the Meeting, Orlando, FL, Apr. 14-16, 1993

    NASA Technical Reports Server (NTRS)

    Huck, Friedrich O. (Editor); Juday, Richard D. (Editor)

    1993-01-01

    Various papers on visual information processing are presented. Individual topics addressed include: aliasing as noise, satellite image processing using a hammering neural network, edge-detetion method using visual perception, adaptive vector median filters, design of a reading test for low-vision image warping, spatial transformation architectures, automatic image-enhancement method, redundancy reduction in image coding, lossless gray-scale image compression by predictive GDF, information efficiency in visual communication, optimizing JPEG quantization matrices for different applications, use of forward error correction to maintain image fidelity, effect of peanoscanning on image compression. Also discussed are: computer vision for autonomous robotics in space, optical processor for zero-crossing edge detection, fractal-based image edge detection, simulation of the neon spreading effect by bandpass filtering, wavelet transform (WT) on parallel SIMD architectures, nonseparable 2D wavelet image representation, adaptive image halftoning based on WT, wavelet analysis of global warming, use of the WT for signal detection, perfect reconstruction two-channel rational filter banks, N-wavelet coding for pattern classification, simulation of image of natural objects, number-theoretic coding for iconic systems.

  12. Infrared readout electronics; Proceedings of the Meeting, Orlando, FL, Apr. 21, 22, 1992

    NASA Technical Reports Server (NTRS)

    Fossum, Eric R. (Editor)

    1992-01-01

    The present volume on IR readout electronics discusses cryogenic readout using silicon devices, cryogenic readout using III-V and LTS devices, multiplexers for higher temperatures, and focal-plane signal processing electronics. Attention is given to the optimization of cryogenic CMOS processes for sub-10-K applications, cryogenic measurements of aerojet GaAs n-JFETs, inP-based heterostructure device technology for ultracold readout applications, and a three-terminal semiconductor-superconductor transimpedance amplifier. Topics addressed include unfulfilled needs in IR astronomy focal-plane readout electronics, IR readout integrated circuit technology for tactical missile systems, and radiation-hardened 10-bit A/D for FPA signal processing. Also discussed are the implementation of a noise reduction circuit for spaceflight IR spectrometers, a real-time processor for staring receivers, and a fiber-optic link design for INMOS transputers.

  13. Optical pattern recognition III; Proceedings of the Meeting, Orlando, FL, Apr. 21, 22, 1992

    NASA Technical Reports Server (NTRS)

    Casasent, David P. (Editor); Chao, Tien-Hsin (Editor)

    1992-01-01

    Consideration is given to transitioning of optical processing into systems (TOPS), optical correlator hardware, phase-only optical correlation filters, optical distortion-invariant correlation filters, and optical neural networks. Particular attention is given to a test target for optical correlators, a TOPS electronic warfare channelizer program, a portable video-rate optical correlator, a joint transform correlator employing electron trapping materials, a novelty filtered optical correlator using a photorefractive crystal, a comparison of correlation performance of smart ternary phase-amplitude filters with gray-scale and binary input scenes, real-time distortion-tolerant composite filters for automatic target identification, landscaping the correlation surface, fast designing of a circular harmonic filter using simulated annealing, feature-based correlation filters for distortion invariance, automatic target recognition using a feature-based optical neural network, and a holographic inner-product processor for pattern recognition.

  14. Illinois. State Supplement. The 10th Annual AP[R] Report to the Nation

    ERIC Educational Resources Information Center

    College Board, 2014

    2014-01-01

    This report provides educators and policymakers with information they can use to celebrate their successes, understand their unique challenges, and set meaningful goals to increase opportunity for all students. It is important to note that while AP® Exams are valid measures of students' content mastery of college-level studies in specific academic…

  15. Applications of artificial neural networks; Proceedings of the Meeting, Orlando, FL, Apr. 18-20, 1990

    SciTech Connect

    Rogers, S.K.

    1990-01-01

    The present conference discusses artificial neural networks (ANNs) for automatic target recognition, theory of networks for learning, abductive networks, target recognition in parallel networks, ANN recognition of atomic and molecular species, multispectral image fusion with ANNs, radar warning/emitter identification processing by ANNs, IR target motion estimation by ANNs, and the analog hardware implementation of neocognition networks. Also discussed are a multidimensional Kohonen net on a HyperCube, robot learning, probabilistic neural networks, ANNs for interpolation and extrapolation, knowledge-base browsing with hybrid distributed/local connectionist networks, predicate calculus for ANNs, abductive networks for electronic warfare, uncertainty computations in ANNs, and the classification power of multiple-layer ANNs.

  16. Smart battery controller for lithium/sulfur dioxide batteries. Technical report, Jan 89-Apr 91

    SciTech Connect

    Atwater, T.; Bard, A.; Testa, B.; Shader, W.

    1992-08-01

    Each year, the U.S. Army purchases millions of lithium sulfur dioxide batteries for use in portable electronics equipment. Because of their superior rate capability and service life over a wide variety of conditions, lithium batteries are the power source of choice for military equipment. There is no convenient method of determining the available energy remaining in partially used lithium batteries; hence, users do not take full advantage of all the available battery energy. Currently, users replace batteries before each mission, which leads to premature disposal, and results in the waste of millions of dollars in battery energy every year. Another problem of the lithium battery is that it is necessary to ensure complete discharge of the cells when the useful life of the battery has been expended, or when a hazardous condition exists; a hazardous condition may result in one or more of the cells venting. The Electronics Technology and Devices Laboratory has developed a working prototype of a smart battery controller (SBC) that addresses these problems.

  17. Race to the Top. Massachusetts. State-Reported APR: Year One

    ERIC Educational Resources Information Center

    US Department of Education, 2012

    2012-01-01

    This paper describes Massachusetts' progress in implementing a comprehensive and coherent approach to education reform from the time of application through June 30, 2011. In particular, it highlights key accomplishments over the reporting period in the four reform areas: standards and assessments, data systems to support instruction, great…

  18. Laser research at the Frank J. Seiler Research Lab. Report for Sep 80-Apr 82

    SciTech Connect

    Shaw, G.L.; Saito, T.T.

    1982-05-20

    The Frank J. Seiler Research Laboratory (FJSRL) is an Air Force Systems Command (AFSC) organization charged with (1) planning and executing USAF research programs in aerospace-mechanics, applied mathematics and chemistry; (2) supporting research by USAF Academy faculty and cadets; and (3) functioning as the AFSC focal point for USAF Academy research and development efforts proposed for AFSC sponsorship. FJSRL is the only USAF basic research lab. Within the Aerospace-Mechanics Directorate, the authors have two projects which are particularly suited to the total mission outlined above. These are the laser gyro and laser damage projects. They discuss both the background and plans for each of these experimental research efforts.

  19. Annual Performance Report. FFY 2012. Revised Clarification April 30, 2014. APR Template-Part B.

    ERIC Educational Resources Information Center

    Bureau of Indian Education, 2014

    2014-01-01

    During school year (SY) 2012-2013, the Bureau of Indian Education (BIE) continued its efforts to improve the validity and reliability of data reporting. BIE data collections are dependent on school level entry (self-reporting) into the Native American Student Information System (NASIS) or into the BIE's Academic Report (formerly the BIEs…

  20. Research, development, and demonstration of algal production raceway (APR) systems for the production of hydrocarbon resources

    SciTech Connect

    Laws, E.A.

    1984-02-01

    A fractional factorial experimental design was used to determine the maximum production and photosynthetic efficiency that could be achieved in shallow algal mass culture systems (SAMCS) of the marine diatom Phaeodactylum tricornutum. Dilution rate and CO/sub 2/ supply were found to be the most important system parameters. Maximum production was found to be about 25 g dry wt m/sup -2/d/sup -1/. This production corresponded to a photosynthetic efficiency of 5.6%. These figures are 50 to 100% better than the production rates achieved in earlier P. tricornutum cultures using conventional culture techniques. The results are consistent with a theoretical model of the impact of the flashing light effect on algal mass culture production. This model predicts that at the typical irradiances in Hawaii, full utilization of the flashing light effect should enhance production by 70% to over 200%. It was concluded that the use of foil arrays in the experimental flume creates systematic vertical mixing on a time scale suitable for utilizing the flashing light effect. Production of P. tricornutum culture is probably limited by temperature. P. tricornutum cannot survive at temperatures in excess of 25/sup 0/C in outdoor mass cultures. Growth of mesophilic species in the temperature range 30 to 35/sup 0/C may well result in even higher production than that achieved with P. tricornutum.

  1. Atmospheric propagation and remote sensing; Proceedings of the Meeting, Orlando, FL, Apr. 21-23, 1992

    SciTech Connect

    Kohnle, A.; Miller, W.B.

    1992-01-01

    Topics addressed include modeling aerosol extinction in a coastal environment, a specific marine boundary layer aerosol model, light scattering of fractal aerosol aggregates using a T-matrix method, a lidar inversion technique using total attenuation and the lidar system constant, a comparison of two retrieval methods for ground reflectance, a two-wavelength lidar inversion technique, and conceptual design of a spaceborne radar for rain and cloud sensing. Also discussed are an energy balance model for imagery and electromagnetic propagation, short-exposure imaging of nonisoplanatic objects through turbulence, atmospheric modeling with an intent of training a neural net wavefront sensor, effect of random layers on atmospheric propagation, atmospheric effects on laser radar performance at 2 microns, the adjacency-blurring effect of scenes modeled by the radiosity method, atmospheric transmittance measurements of CO2 and near-IR laser radiation over 8.6 km, and a comparison of turbulence modulation transfer function (MTF) and aerosol MTF.

  2. AFRRI reports, second quarter 1992. Rept. for Apr-Jul 92

    SciTech Connect

    Not Available

    1992-07-01

    This report includes the following topics: Short and long courses of ofloxacin therapy of Klebsiella pneumoniae sepsis following irradiation, Possible 'accelerated striatal aging' induced by 56Fe heavy-particle irradiation: Implications for manned space flights, Modulation of mortality by tissue trauma and sepsis in mice after radiation injury, Cytokine therapy in canine and primate models of radiation-induced marrow aplasia, Comparison of behavioral and radioprotective effects of WR-2721 and WR-3689, Energy transfer mechanisms in DNA: Relationship to energy deposition in sub-microscopic volumes, Role of interleukin 6 (IL-6) in protection from lethal irradiation and in endocrine responses to IL-1 and tumor necrosis factor, Effects on enhancing hemopoietic reconstitution and increasing survival following exposure to ionizing radiation, and Radioprotection of hematopoietic tissues in mice by lipoic acid.

  3. 15 CFR 781.2 - Purposes of the Additional Protocol and APR.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Protocol (see IAEA Information Circular, INFCIRC/540, at http://www.iaea.org/Publications/Documents... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Purposes of the Additional Protocol... Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE ADDITIONAL...

  4. Progress in holography; Proceedings of the Meeting, The Hague, Netherlands, Mar. 31-Apr. 2, 1987

    NASA Astrophysics Data System (ADS)

    Ebbeni, Jean

    1987-01-01

    Materials and fabrication methods for holographic devices are discussed in reviews and reports. The current status of optical technology in the Netherlands is surveyed, and particular attention is given to the optimization of photorefractive sillenites, four-wave interaction phenomena in holographic scattering, the photorefractive effect due to holes in undoped Be12GeO20 crystals, a holographic optical-element fiber coupler for the NIR, holographic secondaries for telescopes, and a binary synthetic phase-only filter with a random mask. Also considered are real-time holographic three-dimensional imaging based on multiplexing techniques and optoelectronic holograms, rainbow contouring by holographic multiplexing, optical pulse compression by a holographic method, and simulation of the thermal characteristics of substrates.

  5. Space Congress, 29th, Cocoa Beach, FL, Apr. 21-24, 1992, Proceedings

    NASA Technical Reports Server (NTRS)

    1992-01-01

    The present volume on the quest for new frontiers in space discusses weather impacts on space operations, planning for the performance of future space bases, a new guidance and control unit for the Titan IV vehicle, and nondestructive evaluation of Shuttle Columbia tiles. Attention is given to Space Shuttle payload accommodations and trends in customer demands, a generic propellants transfer unit, making space part of general education, space station on-orbit solar array loads during assembly, and dimensional stability of the attitude reference assembly on SSF. Topics addressed include National Launch System payload accommodations and launch operations, the integrated factory/launch site processing concept, Pioneer 10 interstellar studies, and the role of advanced nuclear propulsion systems in precursor interstellar missions. Also discussed are legal challenges in realizing interstellar initiatives, Mars transportation system synthesis, and NASA's commercial space program.

  6. La radiothérapie du cancer de l'endomètre: expérience de l'institut national d'oncologie à propos de 52 cas

    PubMed Central

    Mezouri, Imane; Berhili, Soufiane; Mouhajir, Nawal; Bellefqih, Sara; Elkacemi, Hanan; Kebdani, Tayeb; Benjaafar, Noureddine

    2016-01-01

    Le cancer de l'endomètre est le cancer gynécologique le plus fréquent en occident. Il concerne principalement les femmes ménopausées. L'objectif de notre travail est de rapporter l'expérience du service de radiothérapie à l'Institut National d'Oncologie (INO) dans la prise en charge du cancer de l'endomètre. Nous avons analysé rétrospectivement 52 cas de cancer de l'endomètre traités dans le service de radiothérapie de l'INO entre 2007 à 2009. Les données collectées à partir des dossiers médicaux de nos patientes concernaient les aspects épidémiologiques, cliniques, thérapeutiques et évolutifs de ce cancer. La médiane d’âge des patientes était de 57 ans, 87% étaient ménopausées. Le délai moyen de consultation était de six mois. Le maitre symptôme était des métrorragies chez 51 patientes. Le diagnostic histologique a été porté sur un curetage biopsique de l'endomètre dans 51% des cas. L'examen anatomopathologique a montré un adénocarcinome endométrioïde dans 92% des cas. Après le bilan, 27% des patientes étaient stade I, 30% stade II, 20% stade III et 1% stade IVA selon la classification de la Fédération Internationale de Gynécologie Obstétrique (FIGO). Après la chirurgie, 51% des patientes ont reçu une radiothérapie externe. La dose délivrée était de 46 Gray (Gy). Une curiethérapie du fond vaginal a été délivrée chez toutes les patientes. Sur le plan évolutif, 83% des patientes étaient toujours suivies en situation de bon contrôle de leur maladie, 8% ont eu une récidive locorégionale et 4% avaient des métastases à distance. Ainsi, le cancer de l'endomètre est un cancer dont le traitement repose sur la chirurgie. La radiothérapie est le traitement adjuvant principal. PMID:27279969

  7. Les sepsis intra-abdominaux diffus post-operatoires: aspects épidémiologiques, diagnostiques et thérapeutiques au Service de Chirurgie Générale du CHU Aristide Le Dantec de Dakar

    PubMed Central

    Touré, Alpha Oumar; Cissé, Mamadou; Ka, Ibrahima; Dieng, Madieng; Konaté, Ibrahima; Ka, Ousmane; Touré, Cheikh Tidiane

    2014-01-01

    Les sepsis intra-abdominaux diffus postopératoires (SIADPO) ont encore une fréquence alarmante. Ils mettent rapidement en cause l'intégrité des grandes fonctions. Le but de cette étude était d’évaluer leur prise en charge. Il s'agissait d'une étude rétrospective descriptive sur 10 ans (janvier 2000 à décembre 2009) portant sur 45 cas de SIADPO. Nous avons étudié les aspects épidémiologiques, diagnostiques, thérapeutiques et pronostiques. Il s'agissait de 45 cas dont 25 hommes et 20 femmes avec un sex-ratio de 1,25. L’âge moyen des patients était de 34 ans avec des extrêmes de 20 et 70 ans. Le SIADPO survenait au décours d'une intervention septique en urgence dans 68,8% des cas. Le délai moyen de diagnostic était de 10 jours. Les signes cliniques étaient dominés par les troubles du transit (80%), la douleur abdominale (77,7%), la fièvre (66,7%), le météorisme abdominal (33%). Une hyperleucocytose a été retrouvée dans 60% des cas. Le liquide intra-abdominal était polymicrobien. Tous les patients ont bénéficié d'une laparotomie xipho-pubienne dans les 72 heures. Nous avons noté 82,2% de péritonites secondaires notamment post-opératoires et 17,8% de péritonites persistantes. Les étiologies étaient dominées par le lâchage de suture digestive ou gynécologique (66,7% des cas). La stomie digestive a été le geste le plus fréquemment réalisé (41%). La guérison est survenue chez 75,5%. La morbidité opératoire était de 42% faite de suppuration pariétale (10 cas), de fistule entérocutanée (6 cas), d’éviscération (2 cas). La mortalité était de 24,5% en rapport avec le retard diagnostique et les défaillances multi-viscérales. Les interventions septiques en urgence sont les plus grandes pourvoyeuses de SIADPO. La mortalité reste encore élevée en rapport avec la défaillance viscérale. La précocité du diagnostic et de la réintervention conditionnent ainsi le pronostic. PMID:25161748

  8. Léiomyosarcome du pancréas: une tumeur de mauvais pronostic - cas clinique et revue de la littérature

    PubMed Central

    Laalim, Said Ait; Hijri, Fatim Zahra; Kamaoui, Imane; Hassani, Karim Ibn Majdoub; Toughai, Imane; Mazaz, Khalid

    2012-01-01

    Le léiomyosarcome (LMS) primitif du pancréas est une tumeur mésenchymateuse rare (0,1% des tumeurs pancréatiques), seulement 47 cas ont été publiés la littérature depuis 1951. Le diagnostique est basée sur l’immunohistochimie. C’est une tumeur très agressive et souvent découverte à un stade avancé. Nous rapportant le cas d’un patient de 40 ans qui présentait un léiomyosarcome primitif du pancréas de la queue du pancréas avec envahissement de la rate et la partie gauche du colon transverse. Une spléno-pancréatectomie caudale carcinologique avec une colectomie segmentaire était réalisée. Des nodules péritonéaux ont apparus 2 mois après l’intervention au niveau du site opératoire et le paient est décédé 3 mois en postopératoire. Le LMS primitif du pancréas doit être évoqués devant les volumineuses tumeurs du pancréas. Une chirurgie carcinologique est le seul traitement curatif. Le pronostic de ces tumeurs est mauvais et la médiane de survie de ces tumeurs ne dépasse pas 2 ans. PMID:23024830

  9. Récidive de mélanome malin unguéal achromique: à propos d'un cas

    PubMed Central

    Benyass, Youssef; Chafry, Bouchaib; Koufagued, Kaldadak; Bouabid, Salim; Benchebba, Driss; Chagar, Belkacem

    2015-01-01

    Le mélanome malin unguéal représente 1,8 à 8,1% des mélanomes malins cutanés. Sa prise en charge s'adresse aujourd'hui aux praticiens de différentes spécialités. L'acte chirurgical initial est une étape incontournable du traitement curatif. La biopsie de la lésion doit être complète, afin de déterminer de façon exacte la profondeur de l'envahissement en cas de malignité. Nous rapportons un cas de mélanome malin achromique à localisation unguéal chez une femme. La chirurgie initiale consistait en une amputation transphalangienne proximale. L’évolution après deux ans était marquée par une récidive avec extension vers le carpe. Ayant subie une reprise chirurgicale avec une exérèse large. Le traitement des récidives est palliatif et vise à apporter un confort de vie au patient. Le principe du traitement fait appel à l'exérèse chirurgicale des lésions. Des alternatives thérapeutiques sont à l’étude. PMID:26977229

  10. Appliance Repairer. D.O.T. 637.261-018, 723.381-010, 827.261-010. Competency-Based Education. Instructor's Manual. Instructor's Package (Task Assignment Sheets APR-001 through APR-070). Student Package.

    ERIC Educational Resources Information Center

    Murray State Univ., KY.

    This package contains both an instructor's manual and student materials for a course in appliance repair. The instructor's manual is designed to aid the instructor in the use of the Kentucky Appliance Repairer Competency Based Task Assignment System. Following a description of the field and a list of 77 references, the instructor's manual is…

  11. Superconductivity applications for infrared and microwave devices II; Proceedings of the Meeting, Orlando, FL, Apr. 4, 5, 1991

    NASA Technical Reports Server (NTRS)

    Heinen, Vernon O. (Editor); Bhasin, Kul B. (Editor)

    1991-01-01

    Topics discussed include thin-film technology, microwave transmission lines and resonators, microwave devices and circuits, infrared detectors and bolometers, and superconducting junctions. Papers are presented on possible enhancement in bolometric response using free-standing film of YBa2Cu3O(x), aging and surface instability in high-Tc superconductors, epitaxial Tl2Ba2CaCu2O8 thin films on LaAlO3 and their microwave device properties, the performance of stripline resonators using sputtered YBCO films, and a coplanar waveguide microwave filter of YBa2Cu3O7. Attention is also given to the performance characteristics of Y-Ba-Cu-O microwave superconducting detectors, high-Tc bolometer developments for planetary missions, infrared detectors from YBaCuO thin films, high-temperature superconductor junction technology, and submillimeter receiver components using superconducting tunnel junctions.

  12. Superconductivity applications for infrared and microwave devices; Proceedings of the Meeting, Orlando, FL, Apr. 19, 20, 1990

    NASA Technical Reports Server (NTRS)

    Bhasin, Kul B. (Editor); Heinen, Vernon O. (Editor)

    1990-01-01

    Various papers on superconductivity applications for IR and microwave devices are presented. The individual topics addressed include: pulsed laser deposition of Tl-Ca-Ba-Cu-O films, patterning of high-Tc superconducting thin films on Si substrates, IR spectra and the energy gap in thin film YBa2Cu3O(7-delta), high-temperature superconducting thin film microwave circuits, novel filter implementation utilizing HTS materials, high-temperature superconductor antenna investigations, high-Tc superconducting IR detectors, high-Tc superconducting IR detectors from Y-Ba-Cu-O thin films, Y-Ba-Cu0-O thin films as high-speed IR detectors, fabrication of a high-Tc superconducting bolometer, transition-edge microbolometer, photoresponse of YBa2Cu3O(7-delta) granular and epitaxial superconducting thin films, fast IR response of YBCO thin films, kinetic inductance effects in high-Tc microstrip circuits at microwave frequencies.

  13. Calibration of passive remote observing optical and microwave instrumentation; Proceedings of the Meeting, Orlando, FL, Apr. 3-5, 1991

    NASA Technical Reports Server (NTRS)

    Guenther, Bruce W. (Editor)

    1991-01-01

    Various papers on the calibration of passive remote observing optical and microwave instrumentation are presented. Individual topics addressed include: on-board calibration device for a wide field-of-view instrument, calibration for the medium-resolution imaging spectrometer, cryogenic radiometers and intensity-stabilized lasers for EOS radiometric calibrations, radiometric stability of the Shuttle-borne solar backscatter ultraviolet spectrometer, ratioing radiometer for use with a solar diffuser, requirements of a solar diffuser and measurements of some candidate materials, reflectance stability analysis of Spectralon diffuse calibration panels, stray light effects on calibrations using a solar diffuser, radiometric calibration of SPOT 23 HRVs, surface and aerosol models for use in radiative transfer codes. Also addressed are: calibrated intercepts for solar radiometers used in remote sensor calibration, radiometric calibration of an airborne multispectral scanner, in-flight calibration of a helicopter-mounted Daedalus multispectral scanner, technique for improving the calibration of large-area sphere sources, remote colorimetry and its applications, spatial sampling errors for a satellite-borne scanning radiometer, calibration of EOS multispectral imaging sensors and solar irradiance variability.

  14. Space Electrochemical Research and Technology Conference, 3rd, NASA Lewis Research Center, Cleveland, OH, Apr. 9, 10, 1991, Proceedings

    NASA Technical Reports Server (NTRS)

    Warshay, Marvin (Editor)

    1991-01-01

    The proceedings of NASA's third Space Electrochemical Research and Technology (SERT) conference are presented. The objective of the conference was to assess the present status and general thrust of research and development in those areas of electrochemical technology required to enable NASA missions in the next century. The conference provided a forum for the exchange of ideas and opinions of those actively involved in the field, in order to define new opportunities for the application of electrochemical processes in future NASA missions. Papers were presented in three technical areas: the electrochemical interface, the next generation in aerospace batteries and fuel cells, and electrochemistry for nonenergy storage applications.

  15. Injury and destruction of Moraxella-Acinetobacter in the radappertization process. Final Report Apr 78-1 May 80

    SciTech Connect

    Maxcy, R.B.; Rowley, D.B.

    1981-02-01

    Some highly radiation-resistant Moraxella-Acinetobacter (M-A) may survive the radappertization process for meat preservation, because these vegetative bacteria are more resistant than spores to radiation. They are, however, more susceptible than spores to other destructive factors. This work was to determine the effect of some environmental factors that influence the radappertization process. M-A, M. radiodurans, and B. cereus spores varied greatly in their response to changes in temperature of radiation and menstruum in which they were suspended. Available water was critical in response of vegetative cells to radiation. Salts at the level incorporated into meat for the radappertization process suppressed growth of both injured and uninjured M-A. This effect was attributed to reduction in water activity of the menstruum. Freezing and thawing of M-A indicated some destruction and some injury. The injured cells recovered during subsequent incubation. Thus, specific food products and conditions of radappertization must be considered for setting processing parameters. When all the factors of injury, destruction, and suppression of microbial growth are considered in the radappertization process, it is apparent there is little likelihood any of the low number of naturally occurring M-A cells would survive.

  16. Digital and optical shape representation and pattern recognition; Proceedings of the Meeting, Orlando, FL, Apr. 4-6, 1988

    NASA Technical Reports Server (NTRS)

    Juday, Richard D. (Editor)

    1988-01-01

    The present conference discusses topics in pattern-recognition correlator architectures, digital stereo systems, geometric image transformations and their applications, topics in pattern recognition, filter algorithms, object detection and classification, shape representation techniques, and model-based object recognition methods. Attention is given to edge-enhancement preprocessing using liquid crystal TVs, massively-parallel optical data base management, three-dimensional sensing with polar exponential sensor arrays, the optical processing of imaging spectrometer data, hybrid associative memories and metric data models, the representation of shape primitives in neural networks, and the Monte Carlo estimation of moment invariants for pattern recognition.

  17. 78 FR 47051 - Proposed Collection; Comment Request for Forms 943, 943-PR, 943-A, and 943A-PR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-02

    ..., Employer's Annual Tax Return for Agricultural Employees, 943-PR, Planilla Para La Declarcion Anual De La... Para La Declarcion Anual De La Contribucion Federal Del Patrono De Empleados Agricolas (Form...

  18. 75 FR 44847 - Proposed Collection; Comment Request for Forms 943, 943-PR, 943-A, and 943A-PR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-29

    ..., Employer's Annual Tax Return for Agricultural Employees, 943-PR, Planilla Para La Declarcion Anual De La... Employees (Form 943), Planilla Para La Declarcion Anual De La Contribucion Federal Del Patrono De...

  19. Columbus VIII - Symposium on Space Station Utilization, 8th, Munich, Germany, Mar. 30-Apr. 4, 1992, Selected Papers

    NASA Astrophysics Data System (ADS)

    1993-03-01

    The symposium includes topics on the Columbus Programme and Precursor missions, the user support and ground infrastructure, the scientific requirements for the Columbus payloads, the payload operations, and the Mir missions. Papers are presented on Columbus Precursor Spacelab missions, the role of the APM Centre in the support of Columbus Precursor flights, the refined decentralized concept and development support, the Microgravity Advanced Research and Support (MARS) Center update, and the Columbus payload requirements in human physiology. Attention is also given to the fluid science users requirements, European space science and Space Station Freedom, payload operations for the Precursor Mission E1, and the strategic role of automation and robotics for Columbus utilization. Other papers are on a joint Austro-Soviet space project AUSTROMIR-91; a study of cognitive functions in microgravity, COGIMIR; the influence of microgravity on immune system and genetic information; and the Mir'92 project. (For individual items see A93-26552 to A93-26573)

  20. Applications of artificial intelligence X: Machine vision and robotics; Proceedings of the Meeting, Orlando, FL, Apr. 22-24, 1992

    SciTech Connect

    Bowyer, K.W.

    1992-01-01

    Various papers on artificial intelligence in machine vision and robotics are presented. The general topics addressed include: design of a robot head, machine vision inspection techniques, segmentation of fused range and intensity imagery, parallel and VLSI architectures for machine vision, comparison of range image segmentation algorithms, state of the art in postcanny edge detection, simulation and visualization environments for autonomous robots, exploration of recognition by components representation and matching, reactive robotic control strategies, image processing techniques.

  1. Applications of artificial intelligence 1993: Machine vision and robotics; Proceedings of the Meeting, Orlando, FL, Apr. 14-16, 1993

    SciTech Connect

    Boyer, K.L.; Stark, L.

    1993-01-01

    Various levels of machine vision and robotics are addressed, including object recognition, image feature extraction, active vision, stereo and matching, range image acquisition and analysis, sensor models, motion and path planning, and software environments. Papers are presented on integration of geometric and nongeometric attributes for fast object recognition, a four-degree-of-freedom robot head for active computer vision, shape reconstruction from shading with perspective projection, fast extraction of planar surfaces from range images, and real-time reconstruction and rendering of three-dimensional occupancy maps.

  2. Transonic aerodynamics of dense gases. M.S. Thesis - Virginia Polytechnic Inst. and State Univ., Apr. 1990

    NASA Technical Reports Server (NTRS)

    Morren, Sybil Huang

    1991-01-01

    Transonic flow of dense gases for two-dimensional, steady-state, flow over a NACA 0012 airfoil was predicted analytically. The computer code used to model the dense gas behavior was a modified version of Jameson's FL052 airfoil code. The modifications to the code enabled modeling the dense gas behavior near the saturated vapor curve and critical pressure region where the fundamental derivative, Gamma, is negative. This negative Gamma region is of interest because the nonclassical gas behavior such as formation and propagation of expansion shocks, and the disintegration of inadmissible compression shocks may exist. The results indicated that dense gases with undisturbed thermodynamic states in the negative Gamma region show a significant reduction in the extent of the transonic regime as compared to that predicted by the perfect gas theory. The results support existing theories and predictions of the nonclassical, dense gas behavior from previous investigations.

  3. Planets around pulsars; Proceedings of the Conference, California Inst. of Technology, Pasadena, Apr. 30-May 1, 1992

    NASA Technical Reports Server (NTRS)

    Phillips, J. A. (Editor); Thorsett, Steve E. (Editor); Kulkarni, Shri R. (Editor)

    1993-01-01

    Topics addressed include planets and pulsar timing; timing noise in pulsars and alternative explanations; orbital dynamics; planet formation scenarios; searches for disks and other planets; and comets, planetesimals, and debris disks. Particular attention is given to PSR 1257+12 and its planetary companions; the detectability of planetary companions to radio pulsars; orbital dynamics of PSR 1257+12 and its two planetary companions; formation and evolution of pulsars; the circumstellar environment of the GG Tau multiple system; IRAS sources near positions of pulsars; and gamma-ray bursts from planetesimal accretion.

  4. IEEE National Radar Conference, 3rd, University of Michigan, Ann Arbor, MI, Apr. 20, 21, 1988, Proceedings

    NASA Astrophysics Data System (ADS)

    The present conference discusses topics in radar systems and subsystems, radar techniques, radar signal processing, and radar phenomenology. Attention is given to mm-wave radar system tradeoffs, polarimetric X/L/C-band SAR, a VHF radar for tropical jungle terrain elevation modeling, low probability of intercept techniques and implementations, target tracking in maneuver-centered coordinates, advanced techniques for extension of SAR depth-of-focus under arbitrary aircraft maneuvers, and iterative noncoherent angular superresolution. Also discussed are the effect of codebook size on the vector quantization of SAR data, the application of knowledge-based systems to surveillance, digital filters for SAR, novel radar pulse compression waveforms, the theory and application of SAR oceanography, autoregressive modeling of radar data with application to target identification, and a coherent model of radar weather clutter.

  5. Experiments and computational modeling of pulverized-coal ignition. Semiannual report, Apr 1, 1998--Sep 30, 1998

    SciTech Connect

    John C. Chen; Samuel Owusu-Ofori

    1998-10-31

    Under typical conditions of pulverized-coal combustion, which is characterized by fine particles heated at very high rates, there is currently a lack of certainty regarding the ignition mechanism of bituminous and lower rank coals. It is unclear whether ignition occurs first at the particle-oxygen interface (heterogeneous ignition) or if it occurs in the gas phase due to ignition of the devolatilization products (homogeneous ignition). Furthermore, there have been no previous studies aimed at determining the dependence of the ignition mechanism on variations in experimental conditions, such as particle size, oxygen concentration, and heating rate. Finally, there is a need to improve current mathematical models of ignition to realistically and accurately depict the particle-to-particle variations that exist within a coal sample. Such a model is needed to extract useful reaction parameters from ignition studies, and to interpret ignition data in a more meaningful way. The authors propose to examine fundamental aspects of coal ignition through (1) experiments to determine the ignition mechanism of various coals by direct observation, and (2) modeling of the ignition process to derive rate constants and to provide a more insightful interpretation of data from ignition experiments. They propose to use a novel laser-based ignition experiment to achieve their objectives. The heating source will be a pulsed, carbon dioxide laser in which both the pulse energy and pulse duration are independently variable, allowing for a wide range of heating rates and particle temperatures--both of which are decoupled from each other and from the particle size. This level of control over the experimental conditions is truly novel in ignition and combustion experiments. Laser-ignition experiments also offer the distinct advantage of easy optical access to the particles because of the absence of a furnace or radiating walls, and thus permit direct observation and particle temperature measurement. The ignition mechanism of different coals under various experimental conditions can therefore be easily determined by direct observation with high-speed photography. The ignition rate-constants, when the ignition occurs heterogeneously, and the particle heating rates will both be determined from analyses based on direct, particle-temperature measurements using two-color pyrometry.

  6. Mechanisms of microwave-induced blood-brain barrier alterations. Final report 1 Apr 1978-31 Aug 1980

    SciTech Connect

    Lin, J.C.

    1980-09-01

    This investigation was designed to study the mechanisms of interaction between microwaves and the blood-brain barrier and was aimed at correlating changes of blood-brain barrier permeability with the quantity and distribution of absorbed microwave energy inside the brain of adult Wistar rats under sodium pentobarbital anesthesia. Through use of thermographic methods and a direct-contact applicator at the animal's head, the pattern of absorbed microwave energy was determined. Indwelling catheters were placed in the femoral vein. Evans blue in isotonic saline were used as a visual indicator of barrier permeation. Irradiation with pulsed 2450-MHz microwaves for 20 min at average power densities of 0.5 to 2600 mW/squared, which resulted in average specific absorption rates (SARs) of 0.04 to 200 mW/g in the brain, did not produce staining, except in regions that normally are highly permeable. When the incident power density was increased to 3000 mW/squared (SAR of 240 mW/g), extravasation of Evans blue could be seen in the cortex, hippocampus and midbrain.

  7. Biomass energy production. 1975-April, 1980 (citations from the International Aerospace Abstracts Data Base). Report for 1975-Apr 80

    SciTech Connect

    Moore, P.W.

    1980-06-01

    These citations from the international literature describe the production and/or utilization of most forms of biomass as a source of energy, fuel, food, and chemical intermediates or feedstocks. Biomass conversion by incineration, gasification, pyrolysis, hydrolysis, anaerobic digestion, or fermentation, as well as by catalytic, photosynthetic, chemosynthetic, and bio-electrochemical means are among the conversion processes considered. Discussions include biomass plantation and material productivity, transportation and equipment requirements, environmental effects, comparisons of means and efficiencies of utilization and conversion, assessments of limitations, and evaluations of economic potential. (Contains 210 abstracts)

  8. XeF pumped Tm:YLF laser scaling. Final report 1 Apr 80-31 May 81

    SciTech Connect

    Chicklis, E.P.; Baer, J.; Knights, M.; McCarthy, J.

    1984-02-01

    The laser requirements (energy per pulse, average power, beam quality) for the ground based Strategic Laser Communications (SLC) mission represent a significant advance over currently available technology. The combination of very high average power and near diffraction limited beam quality in a spectral region where comparatively few devices have been developed poses a severe challenge to the technology. This report describes work on a Tm:YLF laser, a resonantly pumped, crystalline solid state laser, which emits nominally at 450nm when pumped by the XeF rare gas halide laser. The technical objective of this program was the determination of the feasibility of XeF pumped Tm:YLF as a source for the SLC ground based mission.

  9. Evaluation of electrodialysis for chronic acid recovery and purification at Corpus Christi Army Depot. Final report, Oct 89-Apr 91

    SciTech Connect

    Davis, J.S.

    1991-09-01

    A large quantity of hazardous waste is generated during the maintenance, repair, and overhaul of a wide variety of military equipment at Army depots. Some of this waste is generated by the use of chromic acid solutions for chromium electroplating and the application and removal of chromate conversion coatings. Hazardous waste results when metal contamination builds up in the solutions to such a degree that the solutions must be disposed of as hazardous waste. Removal of this metal contamination should result in a lengthened bath life and reduced hazardous wate generation. As part of its pollution abatement and environmental control mission, the U.S. Army Toxic and Hazardous Materials Agency (USATHAMA) is pursuing R and D projects to assist depots in meeting the Army goal of a 50 percent reduction in hazardous waste by the end of 1992 compared with 1985 baseline levels. In one project, USATHAMA purchased, installed, operated, and evaluated an electrodialysis system on two chromic acid process solutions at Corpus Christi Army Depot (CCAD) in Corpus Christi, Texas. The objective of this task was to evaluate the system's ability to remove metal contamination and oxidize trivalent chromium (an impurity) to hexavalent chromium (chromic acid).

  10. Thermal infrared sensing for diagnostics and control (Thermosense X); Proceedings of the Meeting, Orlando, FL, Apr. 5-8, 1988

    SciTech Connect

    Lucier, R.D.

    1988-01-01

    Instrumentation and applications aspects of IR thermal sensing are discussed in reviews and reports. Topics addressed include standards and ethics, diagnostics of buildings and structures, electronics and microelectronics fabrication monitoring, process and product monitoring and control, facilities and utilities, and ongoing RandD efforts. Consideration is given to airborne IR surveys of roof moisture, thermographic inspection of superplastically formed diffusion-bonded Ti panels, IR surveys of electrical transmission systems, emissivity-independent temperature measurements on low-emissivity targets, IR images of microwave scattering from a ferrite-coated cylinder, and remote thermal imaging of aeroacoustic phenomena.

  11. Advanced development of diagnostics for non-ideal blast flows. Technical report 1 Apr 89-1 Jun 91

    SciTech Connect

    Modarress, D.; Hoeft, T.

    1992-07-01

    Investigations of non-ideal airblast are performed at the Ernst Mach Institute in a shock tube that simulates a radiation-induced thermal layer. Visualization techniques were adequate for overall study of the flow, but did not provide the detailed data for validation of computer codes. Under this contract three tasks were performed to provide needed data. The first task was to develop a software package for analysis of interferogram fringes. This package translates fringes shift due to the presence of helium into densities over the image area. This package was installed at EMI. The second task was to evaluate and test techniques for direct time-varying measurement of gas species concentration. Absorption spectroscopy of NO2 was selected to be used, but had corrosion problems and was abandoned. As a replacement, filtered Rayleigh scattering from Freon gas was identified. The third task was to fabricate and install a multi-location laser Doppler velocimeter system for the shock tube. This unit was installed in the shock tube and preliminary velocity measurements of flow over a rough surface were made.

  12. Spaceflight dynamics 1993; AAS/NASA International Symposium, 8th, Greenbelt, MD, Apr. 26-30, 1993, Parts 1 & 2

    NASA Technical Reports Server (NTRS)

    Teles, Jerome (Editor); Samii, Mina V. (Editor)

    1993-01-01

    A conference on spaceflight dynamics produced papers in the areas of orbit determination, spacecraft tracking, autonomous navigation, the Deep Space Program Science Experiment Mission (DSPSE), the Global Positioning System, attitude control, geostationary satellites, interplanetary missions and trajectories, applications of estimation theory, flight dynamics systems, low-Earth orbit missions, orbital mechanics, mission experience in attitude dynamics, mission experience in sensor studies, attitude dynamics theory and simulations, and orbit-related experience. These papaers covered NASA, European, Russian, Japanese, Chinese, and Brazilian space programs and hardware.

  13. Characterization, propagation, and simulation of infrared scenes; Proceedings of the Meeting, Orlando, FL, Apr. 16-20, 1990

    SciTech Connect

    Watkins, W.R.; Zegel, F.H.; Triplett, M.J.

    1990-01-01

    Various papers on the characterization, propagation, and simulation of IR scenes are presented. Individual topics addressed include: total radiant exitance measurements, absolute measurement of diffuse and specular reflectance using an FTIR spectrometer with an integrating sphere, fundamental limits in temperature estimation, incorporating the BRDF into an IR scene-generation system, characterizing IR dynamic response for foliage backgrounds, modeling sea surface effects in FLIR performance codes, automated imaging IR seeker performance evaluation system, generation of signature data bases with fast codes, background measurements using the NPS-IRST system. Also discussed are: naval ocean IR background analysis, camouflage simulation and effectiveness assessment for the individual soldier, discussion of IR scene generators, multiwavelength Scophony IR scene projector, LBIR target generator and calibrator for preflight seeker tests, dual-mode hardware-in-the-loop simulation facility, development of the IR blackbody source of gravity-type heat pipe and study of its characteristic.

  14. Infrared focal plane array producibility and related materials; Proceedings of the Meeting, Orlando, FL, Apr. 20, 21, 1992

    NASA Astrophysics Data System (ADS)

    Balcerak, Ray; Pellegrini, Paul W.; Scribner, Dean A.

    The present conference discusses the commercial diversification of the U.S. IR detector industry's commercial diversification, HgCdTe focal-plane array (FPAs) manufacture, LPE of (Hg,Cd)Te FPAs, uncooled IR FPA detector producibility, a high performance staring IR camera, and novel technologies for FPA dewars. Also discussed are hybridizing FPAs, cryoprober test development, HgCdTe on Si for monolithic focal plane arrays, popcorn noise in linear InGaAs detector arrays, and the use of narrowband laser speckle for MTF characterization of CCDs. (No individual items are abstracted in this volume)

  15. Modeling of the magnetosphere-ionosphere-atmosphere system. Ph.D. Thesis Semiannual Report, 1 Nov. 1993 - 30 Apr. 1994

    NASA Technical Reports Server (NTRS)

    1994-01-01

    During the period covered by this report we continued to investigate basic processes in magnetosphere-ionosphere coupling and to develop algorithms for analyzing ultraviolet, visible, and X-ray images that will be acquired on the POLAR spacecraft. An image analysis procedure combines several numerical models to obtain a self-consistent picture of the ionosphere and thermosphere. Our ionosphere-aurora model was extended by the inclusion of the magnetic mirror force and a self-consistent parallel electric field in the ionosphere. The electron transport model which forms a critical part of the aurora model was evaluated by comparison with laboratory measurements and auroral observations. We determined the uncertainties that arise from our limited knowledge of cross sections and energy degradation functions for electron neutral interaction.

  16. Metal matrix composites: Testing, analysis, and failure modes; Proceedings of the Symposium, Sparks, NV, Apr. 25, 26, 1988

    NASA Technical Reports Server (NTRS)

    Johnson, W. S. (Editor)

    1989-01-01

    The present conference discusses the tension and compression testing of MMCs, the measurement of advanced composites' thermal expansion, plasticity theory for fiber-reinforced composites, a deformation analysis of boron/aluminum specimens by moire interferometry, strength prediction methods for MMCs, and the analysis of notched MMCs under tensile loading. Also discussed are techniques for the mechanical and thermal testing of Ti3Al/SCS-6 MMCs, damage initiation and growth in fiber-reinforced MMCs, the shear testing of MMCs, the crack growth and fracture of continuous fiber-reinforced MMCs in view of analytical and experimental results, and MMC fiber-matrix interface failures.

  17. Gesellschaft fuer angewandte Mathematik und Mechanik, Scientific Annual Meeting, Universitaet Dortmund, West Germany, Apr. 1-4, 1986, Reports

    NASA Astrophysics Data System (ADS)

    Various papers on applied mathematics and mechanics are presented. The general topics addressed include: mechanics of fluids; numerical treatment of differential equations; optimization, decision theory, stochastics, and insurance mathematics; applied analysis and mathematical physics; and numerical analysis.

  18. Reflective and refractive optical materials for earth and space applications; Proceedings of the Meeting, Orlando, FL, Apr. 4, 5, 1991

    NASA Astrophysics Data System (ADS)

    Riedl, Max J.; Hale, Robert R.; Parsonage, Thomas B.

    The present conference discusses beryllium mirror design and fabrication, production of aspheric beryllium optical surfaces by HIP consolidation, the control of thermally induced porosity for the fabrication of beryllium optics, fine-grained beryllium optical coatings, light-absorbing beryllium baffle materials, and advanced broadband baffle materials. Also discussed are radiation-resistant optical glasses, a catalog of IR and cryooptical properties of selected materials, durable metal-dielectric mirror coatings, the optical stability of diffuse reflectance materials, and optical filters for space applications.

  19. Characterization, propagation, and simulation of infrared scenes; Proceedings of the Meeting, Orlando, FL, Apr. 16-20, 1990

    NASA Astrophysics Data System (ADS)

    Watkins, Wendell R.; Zegel, Ferdinand H.; Triplett, Milton J.

    1990-09-01

    Various papers on the characterization, propagation, and simulation of IR scenes are presented. Individual topics addressed include: total radiant exitance measurements, absolute measurement of diffuse and specular reflectance using an FTIR spectrometer with an integrating sphere, fundamental limits in temperature estimation, incorporating the BRDF into an IR scene-generation system, characterizing IR dynamic response for foliage backgrounds, modeling sea surface effects in FLIR performance codes, automated imaging IR seeker performance evaluation system, generation of signature data bases with fast codes, background measurements using the NPS-IRST system. Also discussed are: naval ocean IR background analysis, camouflage simulation and effectiveness assessment for the individual soldier, discussion of IR scene generators, multiwavelength Scophony IR scene projector, LBIR target generator and calibrator for preflight seeker tests, dual-mode hardware-in-the-loop simulation facility, development of the IR blackbody source of gravity-type heat pipe and study of its characteristic.

  20. Composite materials: Fatigue and fracture; Proceedings of the Second Symposium, Cincinnati, OH, Apr. 27, 28, 1987. Volume 2

    SciTech Connect

    Lagace, P.A.

    1989-01-01

    Topics discussed in this volume are concerned with fatigue and damage growth, models and analysis, delamination, and structural aspects. Papers are presented on the fatigue life prediction of cross-ply composite laminates; damage initiation and growth in notched laminates under reversed cyclic loading; the influence of fiber, matrix, and interface on transverse cracking in carbon-fiber-reinforced plastic cross-ply laminates; edge stresses in woven laminates at low temperatures; and predicting interlaminar fatigue crack growth rates in compressively loaded laminates. Attention is also given to the mode II delamination fracture toughness of unidirectional graphite/epoxy composites, the mode I and mode II delamination of thermosetting and thermoplastic composites, free-edge delamination characteristics in S2/CE9000 glass/epoxy laminates under static and fatigue loads, delamination failure modes in filament-wound composite tubes, and the lateral impact of composite cylinders.

  1. Reflective and refractive optical materials for earth and space applications; Proceedings of the Meeting, Orlando, FL, Apr. 4, 5, 1991

    NASA Technical Reports Server (NTRS)

    Riedl, Max J. (Editor); Hale, Robert R. (Editor); Parsonage, Thomas B. (Editor)

    1991-01-01

    The present conference discusses beryllium mirror design and fabrication, production of aspheric beryllium optical surfaces by HIP consolidation, the control of thermally induced porosity for the fabrication of beryllium optics, fine-grained beryllium optical coatings, light-absorbing beryllium baffle materials, and advanced broadband baffle materials. Also discussed are radiation-resistant optical glasses, a catalog of IR and cryooptical properties of selected materials, durable metal-dielectric mirror coatings, the optical stability of diffuse reflectance materials, and optical filters for space applications.

  2. Signal and image processing systems performance evaluation, simulation, and modeling; Proceedings of the Meeting, Orlando, FL, Apr. 4, 5, 1991

    NASA Astrophysics Data System (ADS)

    Nasr, Hatem N.; Bazakos, Michael E.

    The various aspects of the evaluation and modeling problems in algorithms, sensors, and systems are addressed. Consideration is given to a generic modular imaging IR signal processor, real-time architecture based on the image-processing module family, application of the Proto Ware simulation testbed to the design and evaluation of advanced avionics, development of a fire-and-forget imaging infrared seeker missile simulation, an adaptive morphological filter for image processing, laboratory development of a nonlinear optical tracking filter, a dynamic end-to-end model testbed for IR detection algorithms, wind tunnel model aircraft attitude and motion analysis, an information-theoretic approach to optimal quantization, parametric analysis of target/decoy performance, neural networks for automated target recognition parameters adaptation, performance evaluation of a texture-based segmentation algorithm, evaluation of image tracker algorithms, and multisensor fusion methodologies. (No individual items are abstracted in this volume)

  3. Physiological stress from chemical-defense clothing and equipment. Final report, 1 Apr 90-31 Mar 92

    SciTech Connect

    Nunneley, S.A.

    1992-08-01

    Topics include groundcrew heat stress in Chemical Defense Ensemble (CDE), validation of the heat-humidity index for work in CDE, evaluation of CDE made with various materials, groundcrew cooling devices, and aircrew guidelines. A bibliography is included.

  4. Applications of artificial intelligence X: Knowledge-based systems; Proceedings of the Meeting, Orlando, FL, Apr. 22-24, 1992

    SciTech Connect

    Biswas, G. )

    1992-01-01

    The present conference discusses cognitive mapping as a knowledge-engineering tool, inconsistency checking, abductive signal interpretation for NDE, hypotheticodeductive diagnoses, a parallel architecture for a multiple-input fuzzy logic controller, fuzzy-concept formation, and a case-associative mobile-robot planning system. Also considered are symbolic planning with metric time, the acquisition of teleological descriptions, genetic algorithm learning of scheduling heuristics, dynamical networks for pattern recognition, and an automated AI-based designer of electrical distribution systems.

  5. Contemporary optical instrument design, fabrication, and testing; Proceedings of the Meeting, Innsbruck, Austria, Apr. 17, 18, 1986

    NASA Astrophysics Data System (ADS)

    Beckmann, Leo H. J. F.; Briers, J. D.; Yoder, Paul R., Jr.

    1986-01-01

    Advanced optical instruments are discussed, with a focus on system-integration, fabrication, and testing aspects. Topics addressed include theoretical models for determining temperature transients in multilayer optical thin films subjected to CW and pulsed laser radiation, diamond grinding of optical surfaces on aspheric lens molds, the impact of novel production methods on IR system design, fabrication and testing of highly nonconventional optics, subaperture optical testing, and digital interferogram analysis and DIN norms. Consideration is given to the optical design of the Hipparcos telescope, verification of the Hipparcos payload short-term stability, complementary and analogous information obtained with acoustic and optical microscopy, an IR/visual imaging sea surveillance sensor, a longitudinal chromatic aberration spectroscope, CO2 lidar airspeed measurement, optical systems for gas-turbine engines, and a heterodyne interferometer for surface profile measurements with height resolution 5 nm.

  6. Gesellschaft fuer angewandte Mathematik und Mechanik, Scientific Annual Meeting, Technische Universitaet Wien, Vienna, Austria, Apr. 5-9, 1988, Reports

    NASA Astrophysics Data System (ADS)

    Various papers on applied mathematics and mechanics are presented. The general topics considered include: numerical treatment of implicit differential equations and differential algebraic systems; software for scientific calculation; structural analysis and simulation; stochastic methods; biomathematics; interpolation and approximation; quadrature; optimization; methods in operations research; enclosures for linear and nonlinear equations; enclosures for functional equations; ordinary differential equations and dynamical systems; ordinary differential and difference equations; and numerics of stiff differential equations. Also addressed are: waves, analysis, applications, and numerics in partial differential equations; large systems of linear equations; multigrid methods; iterative processes in applied function theory; discrete mathematics and informatics; fundamentals, special methods, and shells in FEM; beams and special applications; fundamentals, solid mechanics, and fluid mechanics in BEM.

  7. Future European and Japanese remote-sensing sensors and programs; Proceedings of the Meeting, Orlando, FL, Apr. 1, 2, 1991

    SciTech Connect

    Slater, P.N.

    1991-01-01

    Consideration is given to the METEOSAT second-generation program, the ESA earth observation polar platform program, a new satellite for a climatology study in the tropics, a medium-resolution imaging spectrometer, a Michelson interferometer for passive atmosphere sounding, an optical mapping instrument, an optical sensor system for Japanese earth resources satellite 1, a synthetic aperture radar of JERS-1, an ocean color and temperature scanner for Advanced Earth-Observing Satellite (ADEOS), an interferometric monitor for greenhouse gasses for ADEOS. Attention is also given to Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) for EOS-A, short-wave infrared subsystem design status of ASTER, ASTER calibration concept, Japanese polar orbit platform program, and airborne and spaceborne thermal multispectral remote sensing.

  8. Symposium on Electromagnetic Launch Technology, 6th, Univ. of Texas, Austin, Apr. 28-30, 1992, Proceedings

    NASA Astrophysics Data System (ADS)

    Grosser, Julie K.

    1993-01-01

    The present conference discusses topics in the military and commercial applications of electrical launcher systems, electromagnetic and electrothermal 'railgun' launchers, 'coilguns', armature and launcher designs, power-conditioning and energy storage systems, and launcher materials and structures and their diagnostics. Attention is given to an earth-to-orbit railgun launcher, polyphase and multiphase railguns, hypervelocity projectile design, determining the Lorentz forces in plasma armatures, pulse power generators, advanced compulsator technology, airborne-platform electric launcher applications, magnetic design for structural stiffness, current multipliers, pulse-forming network design, and cannon-caliber electromagnetic launchers.

  9. Nicotinic cholinergic receptors in rat brain. Annual report No. 3, 1 May 85-30 Apr 86

    SciTech Connect

    Kellar, K.J.

    1986-05-01

    We have compared the characteristics of the recognition sites for 3(H)acetylcholine and 3H(-)nicotine in rat brain and found that the pharmacology, distribution, disulfide bond requirement, and regulation by chronic administration of nicotine and soman are identical. From these studies we conclude that 3Hacetylcholine and 3H(-)nicotine recognize the same recognition site which has the characteristics expected of a nicotinic cholinergic receptor. We have also determined that 3Hacetylcholine of high specific radioactivity (80 Ci/mmol) is an excellent ligand with which to study muscarinic receptors that have high affinity for agonists. These receptors may represent a subtype of muscarinic receptors found in brain, heart, glands, an some smooth muscle. (JS)

  10. Thematic Conference on Geologic Remote Sensing, 8th, Denver, CO, Apr. 29-May 2, 1991, Proceedings. Vols. 1 & 2

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The proceedings contain papers discussing the state-of-the-art exploration, engineering, and environmental applications of geologic remote sensing, along with the research and development activities aimed at increasing the future capabilities of this technology. The following topics are addressed: spectral geology, U.S. and international hydrocarbon exporation, radar and thermal infrared remote sensing, engineering geology and hydrogeology, mineral exploration, remote sensing for marine and environmental applications, image processing and analysis, geobotanical remote sensing, and data integration and geographic information systems. Particular attention is given to spectral alteration mapping with imaging spectrometers, mapping the coastal plain of the Congo with airborne digital radar, applications of remote sensing techniques to the assessment of dam safety, remote sensing of ferric iron minerals as guides for gold exploration, principal component analysis for alteration mappping, and the application of remote sensing techniques for gold prospecting in the north Fujian province.

  11. Signal processing, sensor fusion, and target recognition; Proceedings of the Meeting, Orlando, FL, Apr. 20-22, 1992

    NASA Astrophysics Data System (ADS)

    Libby, Vibeke; Kadar, Ivan

    Consideration is given to a multiordered mapping technique for target prioritization, a neural network approach to multiple-target-tracking problems, a multisensor fusion algorithm for multitarget multibackground classification, deconvolutiom of multiple images of the same object, neural networks and genetic algorithms for combinatorial optimization of sensor data fusion, classification of atmospheric acoustic signals from fixed-wing aircraft, and an optics approach to sensor fusion for target recognition. Also treated are a zoom lens for automatic target recognition, a hybrid model for the analysis of radar sensors, an innovative test bed for developing and assessing air-to-air noncooperative target identification algorithms, SAR imagery scene segmentation using fractal processing, sonar feature-based bandwidth compression, laboratory experiments for a new sonar system, computational algorithms for discrete transform using fixed-size filter matrices, and pattern recognition for power systems.

  12. Heat Flow and Magnetization in the Oceanic Lithosphere. Ph.D. ThesisSemiannual Report, Nov. 1987 - Apr. 1988

    NASA Technical Reports Server (NTRS)

    Hayling, Kjell Lennart

    1988-01-01

    Two aspects of the processing and interpretation of satellite measurements of the geomagnetic field are described. One deals with the extraction of the part of the geomagnetic field that originates from sources in the earth's atmosphere. The other investigates the possibility of using the thermal state of the oceanic lithosphere to further constrain modelling and interpretation of magnetic anomalies. It is shown that some of the magnetic signal in crustal anomaly maps can be an artifact of the mathematical algorithms that have been used to separate the crustal field from the observed data. Strong magnetic anomalies can be distorted but are probably real, but weak magnetic anomalies can arise from leakage of power from short wavelengths, and will also appear in anomaly maps as repetitions of the strong crustal anomaly. The distortion and the ghost anomalies follow the magnetic dip lines in a way that is similar to actual MAGSAT anomaly fields. This phenomenon will also affect the lower degree spherical harmonic terms in the power spectrum of the crustal field. A model of the magnetic properties of the oceanic crust that has been derived from direct measurements of the rock magnetic properties of oceanic rocks is presented. The average intensity of magnetization in the oceanic crust is not strong enough to explain magnetic anomalies observed over oceanic areas. This is the case for both near surface observations (ship and aeromagnetic data) and satellite altitude observations. It is shown that magnetic sources in the part of the upper mantle that is situated above the Curie isotherm, if sufficiently strong, can produce satellite magnetic anomalies that are comparable to MAGSAT data. The method developed for the study of depth to the Curie isotherm and magnetic anomalies can also be used in inverse modelling of satellite magnetic anomalies when the model is to be adjusted with an annihilator.

  13. Thematic Conference on Geologic Remote Sensing, 8th, Denver, CO, Apr. 29-May 2, 1991, Proceedings. Vols. 1 2

    SciTech Connect

    Not Available

    1991-01-01

    The proceedings contain papers discussing the state-of-the-art exploration, engineering, and environmental applications of geologic remote sensing, along with the research and development activities aimed at increasing the future capabilities of this technology. The following topics are addressed: spectral geology, US and international hydrocarbon exporation, radar and thermal infrared remote sensing, engineering geology and hydrogeology, mineral exploration, remote sensing for marine and environmental applications, image processing and analysis, geobotanical remote sensing, and data integration and geographic information systems. Particular attention is given to spectral alteration mapping with imaging spectrometers, mapping the coastal plain of the Congo with airborne digital radar, applications of remote sensing techniques to the assessment of dam safety, remote sensing of ferric iron minerals as guides for gold exploration, principal component analysis for alteration mappping, and the application of remote sensing techniques for gold prospecting in the north Fujian province.

  14. Frictional ignition suppression by the use of cutter-drum mounted sprays. Open file report Apr 79-Dec 81

    SciTech Connect

    Agbede, R.O.; Whitehead, K.L.; Mundell, R.L.; Saltsman, R.D.

    1982-01-01

    The contract objective was to conduct tests with a full-scale longwall shearer drum in a simulated mine environment to determine the effectiveness of drum-mounted water sprays in controlling frictional ignitions. The tests were conducted with a drum equipped with a single bit that cuts a sandstone block enclosed in a chamber filled with a combustible methane-air mixture. Without the sprays operating no ignition occurred when only the carbide tip was impacting the stone. The likelihood of ignition increased with degree of bit wear and exposed steel contact area. Backflushing sprays, properly applied, were effective in controlling ignitions, but pick flushing and bit-cooling sprays were ineffective. Decreasing drum speed did not reduce the likelihood of ignitions until a bit peripheral speed of 200 fpm, 14 rpm for a 54-inch drum, was reached. A fully laced drum was then designed and tested. Results corroborated the findings of the single-bit tests.

  15. Sensors and sensor systems for guidance and navigation II; Proceedings of the Meeting, Orlando, FL, Apr. 22, 23, 1992

    NASA Technical Reports Server (NTRS)

    Welch, Sharon S. (Editor)

    1992-01-01

    Topics discussed in this volume include aircraft guidance and navigation, optics for visual guidance of aircraft, spacecraft and missile guidance and navigation, lidar and ladar systems, microdevices, gyroscopes, cockpit displays, and automotive displays. Papers are presented on optical processing for range and attitude determination, aircraft collision avoidance using a statistical decision theory, a scanning laser aircraft surveillance system for carrier flight operations, star sensor simulation for astroinertial guidance and navigation, autonomous millimeter-wave radar guidance systems, and a 1.32-micron long-range solid state imaging ladar. Attention is also given to a microfabricated magnetometer using Young's modulus changes in magnetoelastic materials, an integrated microgyroscope, a pulsed diode ring laser gyroscope, self-scanned polysilicon active-matrix liquid-crystal displays, the history and development of coated contrast enhancement filters for cockpit displays, and the effect of the display configuration on the attentional sampling performance.

  16. Excrétion rénale des ions divalents après homotransplantation rénale

    PubMed Central

    Cartier, F.; Popovtzer, M. M.; Robinette, J.; Pinggera, W. F.; Halgrimson, C. G.; Starzl, T. E.

    2010-01-01

    RÉSUMÉ L’élimination rénale des ions divalents, celle du Na et du K, ont été étudiées de façon comparative dans les suites immédiates de l’homotransplantation rénale chez 6 patients. Durant la période initiale polyurique (> 3ml/mn), le taux d’excrétion du Ca filtré (Cca/Ccr), du Mg, du P, du Na et du K, est élevé et il existe une corrélation étroite et quasi constante entre l’élimination du Ca, du Mg et du Na ; la corrélation n’est pas constante entre l’élimination du Na et du K, du Mg et du K. Pendant les deux jours suivants, le taux d’excrétion diminue, sauf pour le P ; il existe encore une corrélation entre l’excrétion du Ca, du Mg et du Na, non entre celle du Na et du K, du Mg et du K. L’excrétion du Ca l’emporte sur celle du Na au cours de la première période, non au cours de la seconde. A la lumière de ces données, on envisage l’intervention possible de divers facteurs, tels l’inflation hydrosique et l’hyperazotémie préalables, l’ischémie rénale contemporaine de la transplantation, les effets de la dénervation rénale, du traitement cortisonique, de l’hyperparathyroïdie et ceux des modifications circulatoires rénales. PMID:4574592

  17. Surface-crack growth: Models, experiments, and structures; Proceedings of the Symposium, Sparks, NV, Apr. 25, 1988

    NASA Technical Reports Server (NTRS)

    Reuter, Walter G. (Editor); Underwood, John H. (Editor); Newman, James C., Jr. (Editor)

    1990-01-01

    The present volume on surface-crack growth modeling, experimental methods, and structures, discusses elastoplastic behavior, the fracture analysis of three-dimensional bodies with surface cracks, optical measurements of free-surface effects on natural surfaces and through cracks, an optical and finite-element investigation of a plastically deformed surface flaw under tension, fracture behavior prediction for rapidly loaded surface-cracked specimens, and surface cracks in thick laminated fiber composite plates. Also discussed are a novel study procedure for crack initiation and growth in thermal fatigue testing, the growth of surface cracks under fatigue and monotonically increasing load, the subcritical growth of a surface flaw, surface crack propagation in notched and unnotched rods, and theoretical and experimental analyses of surface cracks in weldments.

  18. Electrostatics 1987; Proceedings of the Seventh International Conference on Electrostatic Phemomena, Oxford University, England, Apr. 8-10, 1987

    NASA Astrophysics Data System (ADS)

    Sproston, J. L.

    The present conference on electrostatic phenomena and technologies discusses topics in the application of electrostatic effects, the fundamentals and simulation of electrostatic hazards, electrostatic damage (ESD) and its related effects, and measurement and testing methods for electrostatics. Attention is given to space charge and evaporation effects in electrostatic aerial spraying, ink-jet electrostatic drop-deflection printing, static charge elimination methods, ESD in solar panels, contact electrification and conduction in polymers, an in-flight particle charge detector, the gravure development of electrostatic images in electrophotography, and electrostatic hazards in the manufacture of IR decoy flares.

  19. Annual Performance Report. Bureau of Indian Education FFY 2011. Revised Clarification, May 17, 2013. APR Template-Part B

    ERIC Educational Resources Information Center

    Bureau of Indian Education, 2013

    2013-01-01

    During SY 2011-2012, the Bureau of Indian Education (BIE) continued their efforts to improve the validity and reliability of data reporting. BIE data collections are dependent on school level entry (self-reporting) into the Native American Student Information System (NASIS) or into the BIE's Annual Report from the schools. In addition, data…

  20. Effects of blast trauma (impulse noise) on hearing: A parametric study. Final report, 1 Apr 86-31 May 91

    SciTech Connect

    Hamernik, R.P.; Ahroon, W.A.; Turrentine, G.; Davis, R.I.; Hsueh, K.D.

    1991-05-01

    The primary goal of this research project was to produce a data base from which one could estimate the hazards to hearing associated with a wide variety of non-reverberant (free-field) blast were exposures. To achieve this objective four different blast wave generation devices were designed. Three of these sources are based upon shock tube methods and one uses a high energy electrical discharge to produce a shock wave. The four sources produce pressure-time waveforms whose A-weighted amplitude spectra peak at four different regions of the audible spectrum. The conventional shock tube (Source I) has maximum A-weighted energy in the 0.250 kHz octave band; the 5-inch Lamont rapid acting valve driven shock tube (Source II) has its energy maxima in the 2 kHz octave band; while the spark discharge energy (Source III) has its energy maxima in the 2 kHz octave band; while the spark discharge energy (Source IV) is concentrated in the 4 and 8 kHz octave band. These sources in anechoic surroundings produce non-reverberant waves that approximate the ideal Friedlander wave.

  1. 78 FR 17223 - Notice of Submission of Proposed Information Collection to OMB: Annual Progress Report (APR) for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-20

    ... Program (SHP), Shelter Plus Care (S+C) Program, and the Section 8 Moderate ] Rehabilitation for the Single.... Members of the affected public: Grant recipients for the Supportive Housing Program (SHP), Shelter...

  2. Disjonction symphysaire après un accouchement par voie basse dystocique: à propos d'un cas

    PubMed Central

    Laadioui, Meriem; Slimani, Wafae; Jayi, Sofia; Alaoui, Fatimazahra Fdili; Bouguern, Hakima; Chaara, Hikmat; Melhouf, Moulay Aabdelilah

    2014-01-01

    La disjonction symphysaire est une affection rare, qui se définie par un élargissement au niveau de l'articulation inter-symphysaire estimé supérieur à 10 mm. Cette affection nécessite une prise en charge spécialisée en cas de douleurs sévères et invalidantes. Nous rapportant le cas d'une patiente présentant des douleurs pelviennes intense avec impotence du MI gauche à J2 d'un accouchement dystocique, l'examen clinique a objectivé une douleur exquise à la palpation de la symphyse pubienne. Le diagnostic a été confirmé par une radiologie du bassin de face objectivant un élargissement de la symphyse pubienne de 15 mm, la prise en charge thérapeutique a consisté en une mise sous décharge et anti-coagulation préventive avec un traitement antalgique à base de paracétamol et AINS. L’évolution était favorable. A travers notre cas, nous insisterons sur les caractéristiques de cette pathologie notamment pronostic, ce qui permettra au praticien de comprendre l'intérêt du diagnostic et prise en charge précoce de cette entité qu'elle évoquer devant toute douleurs pelviennes survenant au cours de la grossesse ou en post partum. PMID:24932344

  3. Measuring ocean waves from space; Proceedings of the Symposium, Johns Hopkins University, Laurel, MD, Apr. 15-17, 1986

    NASA Technical Reports Server (NTRS)

    Beal, Robert C. (Editor)

    1987-01-01

    Papers are presented on ocean-wave prediction; the quasi-universal form of the spectra of wind-generated gravity waves at different stages of their development; the limitations of the spectral measurements and observations of the group structure of surface waves; the effect of swell on the growth of wind wave; operational wave forecasting; ocean-wave models, and seakeeping using directional wave spectra. Consideration is given to microwave measurements of the ocean-wave directional spectra; SIR research; estimating wave energy spectra from SAR imagery, with the radar ocean-wave spectrometer, and SIR-B; the wave-measurement capabilities of the surface contour radar and the airborne oceanographic lidar; and SIR-B ocean-wave enhancement with fast-Fourier transform techniques. Topics discussed include wave-current interaction; the design and applicability of Spectrasat; the need for a global wave monitoring system; the age and source of ocean swell observed in Hurricane Josephine; and the use of satellite technology for insulin treatment.

  4. Brulures Profondes des Membres Apres Intoxication au Co Par Usage du Barbecue Traditionnel en Salle de Bain

    PubMed Central

    Chraïbi, R.; Moussaoui, A.; Tourabi, K.; Ennouhi, A.; Ihrai, H.; Hassam, B.

    2007-01-01

    Summary En l'absence des moyens de chauffage moderne à domicile chez une proportion non négligeable des Marocains, le recours au moyen traditionnel est fréquent. A travers six observations de brûlures profondes des membres, particulières par leur mode de survenue et par leur gravité, les Auteurs attirent l'attention sur le danger de l'utilisation du barbecue traditionnel «majmer» pour réchauffement en milieu clos. PMID:21991072

  5. Le dermatofibrosarcome de Darier et Ferrand, une tumeur cutanée particulière: à propos de 32 cas et revue de la littérature

    PubMed Central

    Elamrani, Driss; Droussi, Hatim; Boukind, Samira; Elatiqi, Keltoum; Dlimi, Meriem; Benchamkha, Yassine; Ettalbi, Saloua

    2014-01-01

    Le dermatofibrosarcome (DFS) est une tumeur fibreuse de la peau, de croissance lente, à très haut risque de récidive locale, mais à potentiel métastatique faible. A partir d'une étude rétrospective étalée sur une période de 5 ans (décembre 2008 - décembre 2013), nous avons analysé les caractéristiques épidémiologiques et cliniques, le délai de diagnostic, le type de thérapeutique et le devenir de 32 patients présentant des tumeurs de Darier et Ferrand histologiquement prouvées. Parmi les 32 patients, 10 se sont présentés initialement au service pour une récidive tumorale. Une discrète prédominance masculine a été notée. Les DFS touchent préférentiellement l'adulte jeune. Le délai diagnostique observé est en moyenne de 4 ans. Le tronc est la localisation préférentielle (60%), suivi par les extrémités proximales (30%). Les 32 patients ont été traités par exérèse chirurgicale avec une marge de 5cm en surface, emportant en profondeur une barrière anatomique saine. La couverture de la perte de substance (PDS) a été réalisée après confirmation anatomopathologique du caractère carcinologique de l'exérèse, et a fait appel à différents moyens allant de la greffe cutanée aux lambeaux musculo –cutanés libres. L’évolution a été marquée par la survenue d'une récidive tumorale chez 8 patients (3 cas parmi les tumeurs vues en première intention et 5 cas parmi les tumeurs vues en récidive) et les résultats ont été jugés satisfaisants sur le plan esthétique et fonctionnel. Le DFS de Darier et Ferrand est une tumeur dont le pronostic et le risque évolutif sont principalement liés au délai diagnostic et la qualité de la première exérèse. Le diagnostic tardif, rend difficile la chirurgie d'exérèse et de reconstruction Les possibilités de guérison en cas de chirurgie primaire bien conduite sont significativement supérieures à celles d'une chirurgie de rattrapage. L'amélioration du pronostic passe par

  6. La pubalgie du sportif: mise au point à propos d'une étude rétrospective de 128 joueurs

    PubMed Central

    Mahmoudi, Ammar; Frioui, Samia; Jemni, Sonia; Khachnaoui, Faycel; Dahmene, Younes

    2015-01-01

    La pubalgie du sportif de haut niveau représente une entité nosologique à part entière, tant en raison du mécanisme à l'origine de la pathologie que des lésions objectivables au niveau de la paroi abdominale. C'est un syndrome douloureux de la région inguino-pubienne qui touche particulièrement les footballeurs. Son étiologie est attribuée à la répétition de mouvements des membres inférieurs et du tronc associant rotation et adduction forcées. Son incidence est nettement plus élevée chez les hommes. Après avoir écarté une pathologie d'organe, le patient devrait bénéficier tout au début de son traitement conservateur d'une IRM afin d'effectuer un bilan lésionnel complet qui, selon les situations, permet d’écourter le traitement conservateur et de proposer un traitement chirurgical optimal. Le traitement doit être résolument conservateur pendant 3 mois. La rééducation est le plus souvent le traitement de première intention. Les patients présentant une persistance des symptômes sont candidats à la chirurgie. L'intervention de Nesovic est le traitement de choix chez les sportifs de haut niveau et qui permet, dans la très grande majorité des cas, une reprise sans aucune limitation de l'activité sportive antérieure. La technique de Bassini semble être moins lourde que celle de Nesovic, puisqu'elle est moins invasive. Une prise en charge multidisciplinaire centrée sur l'athlète avant et après l'intervention permet un retour aux activités physiques après quelques mois. Nous rapportons l'expérience de la prise en charge de 128 joueurs opérés selon la technique de Bassini et nous comparons nos résultats avec celles de la littérature. PMID:26966484

  7. Schwannome benin primitif retrovesical: une tumeur très rare à propos d'un cas

    PubMed Central

    Beddouche, Ali; Fahsi, Othemane; Kallat, Adil; El Bote, Hicham; Ziani, Idriss; El Sayegh, Hachem; Iken, Ali; Benslimane, Lounis; Nouini, Yassine

    2016-01-01

    Le schwannome est une tumeur le plus souvent bénigne, d'origine nerveuse se développant à partir des cellules de la gaine de Schwann. C'est une tumeur très rare tant par sa fréquence que par sa localisation rétrovésicale. L'examen anatomopathologique et immunohistochimique confirme le type histologique ainsi que le caractère bénin ou malin du schwannome. En raison des récidives, et du risque de transformation maligne, l'exérèse doit être complète. Nous rapportons le cas d'un patient âgé de 39 ans, admis pour une douleur pelvienne chronique à type de pesanteur, des signes irritatifs du bas appareil urinaire, et des troubles de transit. L'imagerie (échographie, TDM, IRM) a révélé la présence d'une masse pelvienne rétrovésicale, à paroi fine, latéralisée à gauche, mesurant 68x70x70 mm, exerçant un effet de masse sur la vessie et le sigmoïde. L'intervention chirurgicale menée par une laparotomie médiane a permis l'exérèse d'une masse retrovésicale bien encapsulée. L'examen anatomopathologique et immunohistochimique ont conclu à un schwannome bénin. La récidive et la transformation maligne bien que rare après chirurgie impose une surveillance post opératoire clinique et tomodensitométrique annuelle. PMID:27217902

  8. Afflux massif de brûlés : la doctrine française de triage en temps de paix

    PubMed Central

    Bargues, L.; Fall, M.M.

    2015-01-01

    Summary Les situations de catastrophe impliquant un grand nombre de brûlés peuvent survenir à tout moment après un incendie, une attaque terroriste, une explosion industrielle ou un accident de transport. Les différentes sociétés internationales de brûlologie ont publié des recommandations sur la préparation à l’afflux massif de brûlés. La Société Française d’Étude et de Traitement des Brûlés (SFETB) propose le triage des victimes selon la Surface Cutanée Brûlée (SCB), l’inhalation de fumées et les lésions traumatiques associées. Ce plan cherche à catégoriser les victimes et à attribuer à chaque patient un lit adapté à ses besoins thérapeutiques (centre des brûlés, réanimation médicale ou chirurgicale, service d’urgences, chirurgie, poste de triage). Les Services d’Aide Médicale Urgente (SAMU) sont au coeur du dispositif : premiers soins, poste Médical Avancé (pMA), régulation, triage et transport, renfort en matériel dans l’hôpital de proximité. Un plan catastrophe pour brûlés doit être adapté aux capacités hospitalières du pays. PMID:26668563

  9. L'endométriose de la paroi abdominale: à propos d'un cas rare

    PubMed Central

    Jayi, Sofia; Laadioui, Meriem; Bouguern, Hakima; Chaara, Hikmat; Melhouf, Aabdelilah

    2013-01-01

    L'endométriose de la paroi est une entité clinique rare, dont la physiopathologie demeure imprécise. Elle survient le plus souvent après une intervention chirurgicale gynécologique ou obstétricale. Nous rapportons le cas d'une patiente présentant une douleur cyclique, au niveau de la cicatrice de césarienne. Avec à l'examen clinique une masse de 3 cm localisée au niveau de la fosse iliaque droite. L'échographie-doppler a objectivé une image d'allure tissulaire, polylobée, à vascularisation centrale, mesurant 32/16 mm, évoquent une masse endométriosique ou une tumeur des parties molles. D'où la décision d'excision de la lésion, au cours de laquelle on a découvert une masse dure de 3/2 cm, en sous aponévrotique accolée au muscle grand droit de l'abdomen. L'étude anatomopathologique a confirmé le diagnostic d'endométriose pariétale. Les suites postopératoires étaient simples avec un recul de 2 ans et demie sans récidive de la masse ni de la douleur. A travers notre cas, nous insisterons sur les caractéristiques de cette pathologie notamment pronostic, ce qui permettra au praticien de comprendre l'intérêt du diagnostic et prise en charge précoce de cette entité - pour laquelle on ne pense jamais assez devant une masse pariétale - et de sa prévention au cours de chaque chirurgie gynécologique ou obstétricale. PMID:24171068

  10. Le mélanome malin: une tumeur rare des fosses nasales - à propos d'une série de 10 cas

    PubMed Central

    Errachdi, Amal; Epala, Brice Nkoua; Asabbane, Amal; Kabbali, Naoual; Hemmich, Mariem; Kebdani, Tayeb; Benjaafar, Noureddine

    2014-01-01

    Le mélanome malin des fosses nasales est une tumeur rare mais très agressive, de traitement complexe et de pronostic défavorable. Son traitement relève en principe d'une prise en charge essentiellement chirurgicale complétée par une radiothérapie. L'objectif de ce travail est de rapporter les caractéristiques cliniques, thérapeutiques et évolutives des mélanomes des fosses nasales. Nous avons analysé rétrospectivement 10 cas de mélanomes des fosses nasales suivis à l'institut national d'oncologie de Rabat. La rhinoscopie avec biopsie a permis la confirmation histologique du diagnostic de mélanome. Le bilan d'extension comprenait une tomodensitométrie ou imagerie par résonnance magnétique du massif facial, une radiographie thoracique et une échographie abdominale. Dans notre série, l’âge médian était de 67.5 ans, avec une prédominance féminine (7femmes et 3hommes). Le délai médian de découverte était de 6 mois. Deux patients étaient métastatiques d'emblée, et toutes les tumeurs étaient localement avancées au moment du diagnostic. Sept patients ont été opérés avec des limites chirurgicales envahies dans 2 cas et 3 patients étaient inopérables. 2 patients ont été irradiés après la chirurgie et 2 patients ont reçu une chimiothérapie arrêtée au moment de la progression. Deux patients ont récidivé après traitement, et un patient était en mauvais état général et a bénéficié uniquement de soins palliatifs. Tous les patients sont décédés avec un délai médian de survie de 12 mois. Le mélanome malin muqueux des fosses nasales, bien que rare, demeure une pathologie de pronostic défavorable et pose des problèmes de prise en charge. PMID:25404963

  11. Éviscération vaginale post hystérectomie récidivante

    PubMed Central

    Traoré, Boubacar Zan; Benmansour, Anis; Hachim, Hajar; Saoud, Oumar; Ekogha, Jean Claude Ekogha; Mbida, Rachida; Chkoff, Rachid Mohammed

    2014-01-01

    L’éviscération vaginale après hystérectomie, bien que rare, est une complication postopératoire grave pour les patients jeunes et les personnes âgées. Chez la femme ménopausée, elle est très souvent due à une chirurgie pelvienne, associée à un trouble de soutien du plancher pelvien. L'iléon distal est l'organe le plus fréquent d’éviscération, mais le prolapsus de l’épiploon, appendice et des trompes de Fallope a été rapportés. Une patiente âgée de 53 ans était admise au service des urgences chirurgicales viscérales en raison d'une masse vaginale apparue sans effort notable. Ses antécédents comportaient une hystérectomie vaginale réalisée en 2009 pour une pathologie bénigne et une éviscération vaginale en 2011 traitée par voie vaginale. L'examen gynécologique révélait une éviscération vaginale d'anses intestinales par une rupture du sommet du vagin. Le segment intestinal hernié, sale, œdématié avec infiltration de la graisse mésentérique est jugé viable. La patiente était opérée en urgence immédiatement après le diagnostic par laparotomie médiane sous-ombilicale. La réintégration en douceur de l'intestin permettait d'objectiver une perforation du sommet du vagin. Cette dernière était fermée par un surjet au fil résorbable après ravivement des berges de la perforation. Le vagin était ensuite fixé au promontoire par des points séparés. Les suites opératoires étaient simples. La patiente sortait de l'hôpital après six jours d'hospitalisation. L’éviscération vaginale est une urgence chirurgicale dont les modalités de prise en charge doivent être connues. Si la laparotomie a longtemps été la technique de référence, la voie vaginale exclusive peut être réalisée en cas d'exploration aisée du segment éviscéré. PMID:25667704

  12. Potential nitrogen contamination of ground water as affected by soil, water, and land-use relationships. Technical report, 1 Apr 89-31 Mar 90

    SciTech Connect

    Crum, J.R.; Pierce, F.J.; Vitosh, M.L.; Knezek, B.D.

    1990-04-01

    To assess nitrate leaching to soil profile characteristics and its association with land use, suction lysimeters were installed in production alfalfa and corn fields and in an adjacent hardwood forest. The amount of N at approximately one meter depth in the soil was greatest in the corn (averaged about 26 ppm N for the year), was less in the alfalfa (averaged about 16 ppm N for the year), and was just above the level of detection (about 0.2 ppm N for the year) in the hardwood forest. N availability is reduced in the second year following alfalfa reducing yield and quality of corn. These effects are more pronounced in no-tillage and ridge-tillage than in conventional tillage systems. Total inorganic N contents in the 0-60 cm soil profile did not vary between tillage or N treatments. The manured soils had significantly higher profile inorganic N contents in July, 1989. Soil nitrate and ammonium levels and potato petiole nitrate concentrations were directly related to the rate of N application and declined with time. Tuber size was significantly improved by either 60 or 120 pounds/acre rate of sidedress N. Specific gravity of potato tubers was unaffected by N application rate.

  13. Étude des anomalies chromosomiques après radiothérapie chez des patients traités pour lymphome malin non-Hodgkinien

    NASA Astrophysics Data System (ADS)

    Mahe, M. A.; André, M. J.; Moyon, E.; Le Mevel, A.; Soubeyran, P.; Hamidou, M.; Milpied, N.; Bourdin, S.; Cuillière, J. C.; Chatal, J. F.

    1998-04-01

    Structural chromosome defects were evaluated in the lymphocytes of 30 patients (pts) who had undergone radiotherapy for non Hodgkin's lymphoma (NHL). Twelve had received 20 Grays (Gy) over the abdomen (group I), 12 whole body irradiation at 1.5 Gy (group II) and 6 whole body irradiation at 15 Gy (group III). A cohort of 468 unirradiated pts served as controls. For the irradiated group, 7% of cells had aberrations compared to 0.4% in controls {P <10-6}. The frequency of abnormal cells was statistically higher in group I (12%) than in group II (3.5%) and III (2.5%) . In group I, frequency of aberrations was statistically higher in pts who had additionnal extra-abdominal involved field irradiation, those with evolutive NHL and those receiving chemotherapy at the time of the cytogenetic analysis. Les aberrations chromosomiques ont ,été, mesurées sur les lymphocytes de 30 patients (pts) irradiés pour lymphome malin non-hodgkinien (LNH) selon 3 modalités : 20 Grays (Gy) sur l'abdomen (groupe I : 12 pts), Irradiation corporelle totale 1,5 Gy (groupe II : 12 pts), ou 15 Gy (groupe III : 6 pts). Une population non irradiée de 468 pts a servi de témoin. Dans le groupe irradié, 7 % des cellules présentaient des anomalies contre 0,4 % dans le groupe témoin {P <10-6}. Les aberrations ,étaient statistiquement plus nombreuses dans le groupe I (12 % des cellules) que dans les groupes II (3,5 %) et III (2,5 %). Dans le groupe I, les anomalies , étaient statistiquement plus fréquentes chez les pts ayant eu une irradiation localisée extra-abdominale en complément de celle de l'abdomen ainsi que chez ceux en rechute de leur LNH et ceux recevant une chimiothérapie lors de l',étude cytogénétique.

  14. Natural and augmented snowfall growth processes and their interactions with the natural and modified aerosol. Final report, 1 March 1989-30 AprIL 1990

    SciTech Connect

    Warburton, J.

    1991-07-01

    The second annual report describes the activities performed under seven separate tasks. These are the same tasks as outlined in the original proposal for the three-year program of research. These tasks dealt with the development of a trace chemical method of assessing the effects of seeding in a snow producing environment and the use of the stable isotopes of water for assessing the regions of ice-phase water capture in the cloud systems from which precipitation fell in the study regions. They also dealt with the theoretical aspects of these trace chemical programs of study and with the roles which trace impurities can play in affecting the growth characteristics of ice particles in supercooled clouds and of the shapes and number fluxes of ice crystals which occur under both natural and artificially seeded conditions. These tasks also included studies of the supercooled liquid water and ice contents of winter storms over the central Sierra Nevada, both spatially and temporally through the use of ground-based remote sensing radar and microwave radiometers. Some work was also conducted on the further development of new aircraft instrumentation for measuring atmospheric motions and the microphysical composition of winter orographic clouds.

  15. Developments in theoretical and applied mechanics. Volume 14; Proceedings of the Fourteenth Southeastern Conference on Theoretical and Applied Mechanics, Biloxi, MS, Apr. 18, 19, 1988

    SciTech Connect

    Wang, S.S.Y.; Hackett, R.M.; Deleeuw, S.L.; Smith, A.M.

    1988-01-01

    The conference presents papers on computational fluid dynamics, coastal hydrodynamics, hydraulics, fluid mechanics, biomechanics, materials, structural mechanics, plates and shells, and numerical methods. Topics include unsteady transonic airfoil computation using implicit Euler scheme on body-fixed grid, the numerical simulation of the vertical flow over a round-edged double-delta wing, MHD modeling of solar active phenomena via numerical methods, and recent developments in turbulent flow. Consideration is also given to modeling of the dynamic sea surface with satellite altimeter signals, the wave structure in unsteady flows past a flat plate in a rotating medium, equivalent systems for variable stiffness plates, and higher order theories for thick transversely isotropic cylindrical shells.

  16. Etude comparative sur la propagation de l'endommagement apres impact des composites carbone/epoxy renforces par piquage au fil Kevlar et titane-nickel

    NASA Astrophysics Data System (ADS)

    Vachon, Pierre-Luc

    Composite laminates have strong in-plane mechanical properties, but they are generally weaker through their thickness. This specificity makes the laminates prone to delamination, particularly under low-velocity impact loads. Consequently numerous research efforts have been dedicated to developing interlaminar reinforcing methods, such as transverse stitching. The present project proposes the use of the stitching technique combined with a special stitching thread made of superelastic TiNi alloy. This technology is intended to improve the delamination toughness in composite laminates loaded in bending. In the first part of this study a numerical model was developed for analyzing composite structures. The 3-D finite element model was built with the ANSYS commercial software using 20-node solid and 8-node shell elements. The progressive damage modeling technique was used, allowing the prediction of delamination propagation in a laminate submitted to various loading modes. The model was validated for a plate under quasi-static traction load, and it was then used to simulate three-point bending tests. Secondly, carbon/epoxy composite panels were fabricated, with each panel containing unstitched and stitched specimens. Two different materials were used for the stitching thread: superelastic TiNi wires and Kevlar threads as a reference. Some stitched specimens were cut in slices in order to make some observations of the internal stitch using an optical microscope. Standardized low-velocity impact tests and compression after impact tests were carried out on stitched and unstitched specimens (ASTM D7136 and D7137). The Kevlar reinforcements have shown great performance in reducing the delaminated zone after impact, as well as in improving the residual compression strength. The TiNi reinforcements provided encouraging results during the impact tests, though being less effective than the Kevlar threads. During the compression after impact tests, only a slight difference could be measured between the TiNi-stitched and the unstitched specimens. Then the bending performance of the specimens was quantified experimentally by calculating the energy required to create a unit volume of damaged material (Gv, J/mm3). This metric is similar to the Strain Energy Release Rate (SERR) commonly used in studies on delamination. According to the experimental results, the damage resistance in three-point bending was not improved by the Kevlar reinforcements, despite the reduced damaged zone after the impact test. Indeed, when the strain energy in bending is relativized to the induced damaged volume during propagation, it turns out that the TiNi reinforcements are more effective than the Kevlar's for improving the damage resistance. Finally, the numerical study on the behavior of both types of stitched reinforcements allowed identifying subtle differences between those. Indeed, both stitching threads (TiNi and Kevlar) promoted the interlaminar propagation of the delamination during simulation of the bending test, with this behavior being less pronounced for the TiNi-stitched plate. However the Kevlar threads seemed more effective for stopping this propagation in the zones between the stitches. Keywords: composite materials, stitching, numerical model, shape memory alloy, three-point bending, low-velocity impact, ultrasound imaging.

  17. Task Order 7. Use of activated carbon for treatment of explosives-contaminated groundwater at the Milan Army Ammunition Plant (MAAP). Final report, Apr 89-May 90

    SciTech Connect

    Dennis, R.M.; Wujcik, W.J.; Lowe, W.L.; Marks, P.J.

    1990-05-01

    The primary objective of this task was to determine the feasibility of using GAC to treat ground water contaminated by explosives at the Milan Army Ammunition Plant (MAAP) in Milan, Tennessee. Laboratory GAC isotherm studies were conducted and two carbons, Atochem, Inc. GAC 830 and Calgon Filtrasorb 300, were selected for further testing in continuous flow GAC columns. Three pilot scale continuous flow GAC column tests were performed at MAAP using the two carbons selected from the laboratory GAC isotherm studies. The results from the laboratory and pilot studies are presented in this report. They show that concurrent removal of explosives such as TNT, RDX, HMX, Tetryl, and nitrobenzenes from ground water using continuous flow granular activated carbon is feasible.

  18. Optical system design, analysis, and production for advanced technology systems; Proceedings of the Meeting, Innsbruck, Austria, Apr. 15-17, 1986

    NASA Technical Reports Server (NTRS)

    Fischer, Robert E. (Editor); Rogers, Philip J. (Editor)

    1986-01-01

    The present conference considers topics in the fields of optical systems design software, the design and analysis of optical systems, illustrative cases of advanced optical system design, the integration of optical designs into greater systems, and optical fabrication and testing techniques. Attention is given to an extended range diffraction-based merit function for lens design optimization, an assessment of technologies for stray light control and evaluation, the automated characterization of IR systems' spatial resolution, a spectrum of design techniques based on aberration theory, a three-field IR telescope, a large aperture zoom lens for 16-mm motion picture cameras, and the use of concave holographic gratings as monochomators. Also discussed are the use of aspherics in optical systems, glass choice procedures for periscope design, the fabrication and testing of unconventional optics, low mass mirrors for large optics, and the diamond grinding of optical surfaces on aspheric lens molds.

  19. Annual Performance Report 2009-2010. Bureau of Indian Education. Submitted February 1, 2011. Revised Clarification, April 18, 2011. APR Template-Part B (4)

    ERIC Educational Resources Information Center

    Bureau of Indian Education, 2011

    2011-01-01

    During SY 2009-2010, the Bureau of Indian Education (BIE) continued their efforts to improve the validity and reliability of data reporting. BIE data collections are dependent on school level entry (self reporting) into the Native American Student Information System (NASIS) or into the Bureau's Annual Report from the schools. In addition,…

  20. Dynamics and control of a five degree-of-freedom magnetic suspension system. Thesis Progress Report, 1 Nov. 1991 - 30 Apr. 1992

    NASA Technical Reports Server (NTRS)

    Haj, Anwar Mohammed; Britcher, Colin P.

    1992-01-01

    A large-gap magnetic suspension system with five degrees-of-freedom is presented. The system is multi-input/multi-output with coupling between degrees-of-freedom. Simulation was performed on this multi degree-of-freedom system in order to control each degree-of-freedom separately. Two types of controllers are considered by adding white noise to a single degree-of-freedom system in order to test their behavior and determine which is the best choice for the system. The responses of the system are produced in continuous and discrete time where a sample interval and delay time was introduced. Using these responses, a comparison between each degree-of-freedom was made and the maximum value of the delay time was determined.

  1. Definition of procedures for chronic exposure of cancer-prone mice to low-level 2,450-MHz radiofrequency radiation. Final report, Jan-Apr 91

    SciTech Connect

    Frei, M.R.; Merritt, J.H.

    1991-09-01

    Several published reports have implied that long-term, low-level exposure to radio-frequency radiation (RFR) may influence the growth and/or differentiation of mammalian cells in vivo. Specifically, the issue involves whether or not such RFR exposure can cause cells to differentiate into an invasive form (tumor induction) or can act as a promoter of tumor expression. To address this issue, the United States Air Force sponsors a project involving long-term exposure of tumor-prone mice to low-level 435-MHz RFR. An earlier onset, greater incidence, or faster growth rate of tumors in the irradiated group, as compared to sham irradiated controls, would suggest an enhanced tumor promotion potential. This investigation is essentially a parallel study to that being conducted at 435 MHz. The critical difference is the exposure frequency; this study will be conducted at 2,450 MHz, which is near the resonant frequency for mice. Knowledge gained from this study will contribute to the ongoing evaluation of safety standards for human exposure to RFR which is essential to the protection of military operational personnel and the general public.

  2. Gesellschaft fuer angewandte Mathematik und Mechanik, Scientific Annual Meeting, Universitaet Hannover, Hanover, Federal Republic of Germany, Apr. 8-12, 1990, Reports

    NASA Astrophysics Data System (ADS)

    Various papers on applied mathematics and mechanics are presented. Among the individual topics addressed are: dynamical systems with time-varying or unsteady structure, micromechanical modeling of creep rupture, forced vibrations of elastic sandwich plates with thick surface layers, postbuckling of a complete spherical shell under a line load, differential-geometric approach to the multibody system dynamics, stability of an oscillator with stochastic parametric excitation, identification strategies for crack-formation in rotors, identification of physical parameters of FEMs, impact model for elastic and partly plastic impacts on objects, varying delay and stability in dynamical systems. Also discussed are: parameter identification of a hybrid model for vibration analysis using the FEM, vibration behavior of a labyrinth seal with through-flow, similarities in the boundary layer of fiber composite materials, distortion parameter in shell theories, elastoplastic crack problem at finite strain, algorithm for computing effective stiffnesses of plates with periodic structure, plasticity of metal-matrix composites in a mixed stress-strain space formation, constitutive equations in directly formulated plate theories, microbuckling and homogenization for long fiber composites.

  3. Rotating machinery - Transport phenomena; Proceedings of the 3rd International Symposium on Transport Phenomena and Dynamics of Rotating Machinery (ISROMAC-3), Honolulu, HI, Apr. 1-4, 1990

    NASA Astrophysics Data System (ADS)

    Kim, J. H.; Yang, W.-J.

    Topics discussed in these proceedings include turbine cooling heat transfer, rotating surfaces, curved ducts and rotating channels, flow in pumps, analytical and numerical methods, design and design methods, and multiphase flow and cavitation. Papers are presented on transient heat analysis of stator in air-cooled turbine generators, numerical evaluation of single central jet for turbine disk cooling, film condensation on a rotating cone, flows of a gas in an abruptly rotating cylinder, developing turbulent flow in a curved duct with strong secondary motion, effects of turn region treatments on pressure loss through sharp 180-deg bends, and examination of inlet surging in centrifugal pumps. Particular attention is given to the prediction of viscous flows in rotating machinery using Navier-Stokes techniques, two-dimensional transonic flow around VKI turbine cascade, the dynamic transfer matrix of a pump and its use in pumping system design, a fast CAE/CAD procedure for the optimum design of arbitrary impellers, particle dynamics and erosion in radial turbine guide vanes, sustained oscillations of pumped two-phase flow in a closed loop, and rotor/stator flow coupling in turbomachines.

  4. Waste water/storm water characterization and toxicity identification evaluation, Sheppard Air Force Base, Texas. Final report, 22 Apr-3 May 91

    SciTech Connect

    McCoy, R.P.; Holck, A.R.; Acker, A.M.

    1991-12-01

    A wastewater characterization survey was conducted at Sheppard AFB TX from 22 April 1991 to 3 May 1991 by personnel from the Water Quality and Environmental Biology Functions of Armstrong Laboratory. Quantitative Data were also collected during a rain event to assess the quality of the storm water runoff from Sheppard AFB. Biomonitoring of the influent and effluent to the Wastewater Treatment Plant (WWTP) was also performed to identify the toxic fraction(s) in the wastewater causing periodic failures in biomonitoring. A qualitative odor survey was also performed to determine if the source of a pungent, onion-like odor could be identified. Measurable concentrations of industrial solvents were found in the wastewater, indicating that some industrial wastes are entering the sanitary sewer system. Phenol concentrations greater than the permitted 50 micrograms per liter were found in many of the sampling sites. The toxic fraction identified in the WWTP influent was an organic electrophile, possibly a petroleum hydrocarbon, oil, grease, or surfactant. The identity of the odor was not conclusively determined, but solids lying in the manholes are thought to be decomposing and emitting noxious gases.

  5. The effects of winglets on low aspect ratio wings at supersonic Mach numbers. M.S. Thesis Report Feb. 1989 - Apr. 1991

    NASA Technical Reports Server (NTRS)

    Keenan, James A.; Kuhlman, John M.

    1991-01-01

    A computational study was conducted on two wings, of aspect ratios 1.244 and 1.865, each having 65 degree leading edge sweep angles, to determine the effects of nonplanar winglets at supersonic Mach numbers. A Mach number of 1.62 was selected as the design value. The winglets studied were parametrically varied in alignment, length, sweep, camber, thickness, and dihedral angle to determine which geometry had the best predicted performance. For the computational analysis, an available Euler marching technique was used. The results indicated that the possibility existed for wing-winglet geometries to equal the performance of wing-alone bodies in supersonic flows with both bodies having the same semispan. The first wing with winglet used NACA 1402 airfoils for the base wing and was shown to have lift-to-pressure drag ratios within 0.136 percent to 0.360 percent of the NACA 1402 wing-alone. The other base wing was a natural flow wing which was previously designed specifically for a Mach number of 1.62. The results obtained showed that the natural wing-alone had a slightly higher lift-to-pressure drag than the natural wing with winglets.

  6. A methodology for airplane parameter estimation and confidence interval determination in nonlinear estimation problems. Ph.D. Thesis - George Washington Univ., Apr. 1985

    NASA Technical Reports Server (NTRS)

    Murphy, P. C.

    1986-01-01

    An algorithm for maximum likelihood (ML) estimation is developed with an efficient method for approximating the sensitivities. The ML algorithm relies on a new optimization method referred to as a modified Newton-Raphson with estimated sensitivities (MNRES). MNRES determines sensitivities by using slope information from local surface approximations of each output variable in parameter space. With the fitted surface, sensitivity information can be updated at each iteration with less computational effort than that required by either a finite-difference method or integration of the analytically determined sensitivity equations. MNRES eliminates the need to derive sensitivity equations for each new model, and thus provides flexibility to use model equations in any convenient format. A random search technique for determining the confidence limits of ML parameter estimates is applied to nonlinear estimation problems for airplanes. The confidence intervals obtained by the search are compared with Cramer-Rao (CR) bounds at the same confidence level. The degree of nonlinearity in the estimation problem is an important factor in the relationship between CR bounds and the error bounds determined by the search technique. Beale's measure of nonlinearity is developed in this study for airplane identification problems; it is used to empirically correct confidence levels and to predict the degree of agreement between CR bounds and search estimates.

  7. Gesellschaft fuer angewandte Mathematik und Mechanik, Scientific Annual Meeting, Universitaet Stuttgart, Federal Republic of Germany, Apr. 13-17, 1987, Reports

    NASA Astrophysics Data System (ADS)

    Recent experimental, theoretical, and numerical investigations of problems in applied mechanics are discussed in reviews and reports. The fields covered include vibration and stability; the mechanics of elastic and plastic materials; fluid mechanics; the numerical treatment of differential equations; finite and boundary elements; optimization, decision theory, stochastics, and actuarial analysis; applied analysis and mathematical physics; and numerical analysis. Reviews are presented on mathematical applications of geometric-optics methods, biomechanics and implant technology, vibration theory in engineering, the stiffness and strength of damaged materials, and the existence of slow steady flows of viscoelastic fluids of integral type.

  8. Gesellschaft fuer angewandte Mathematik und Mechanik, Scientific Annual Meeting, Universitaet Stuttgart, Federal Republic of Germany, Apr. 13-17, 1987, Reports

    NASA Astrophysics Data System (ADS)

    Recent advances in the analytical and numerical treatment of physical and engineering problems are discussed in reviews and reports. Topics addressed include fluid mechanics, numerical methods for differential equations, FEM approaches, and boundary-element methods. Consideration is given to optimization, decision theory, stochastics, actuarial mathematics, applied mathematics and mathematical physics, and numerical analysis.

  9. Engineering, construction, and operations in space II; Proceedings of Space 90, the Second International Conference, Albuquerque, NM, Apr. 22-26, 1990. Vols. 1 & 2

    NASA Technical Reports Server (NTRS)

    Johnson, Stewart W. (Editor); Wetzel, John P. (Editor)

    1990-01-01

    Attention is given to such topics as the processing of lunar soils, the automated processing of extraterrestrial materials, lunar excavation and mining, lunar oxygen, lunar base development, lunar surface structures, planetary surface transportation, and Mars missions. Papers are also presented on the Space Station, space debris, robotics and automated processing, structures and structural response, Mission to Planet Earth, life support systems, space power, human factors, artificial gravity, and education.

  10. Qualitative and quantitative behaviour of planetary systems; Proceedings of the 3rd Alexander von Humboldt Colloquium on Celestial Mechanics, Ramsau, Austria, Mar. 29-Apr. 4, 1992

    NASA Astrophysics Data System (ADS)

    Dvorak, R.; Henrard, J.

    1993-06-01

    Topics addressed include planetary theories, the Sitnikov problem, asteroids, resonance, general dynamical systems, and chaos and stability. Particular attention is given to recent progress in the theory and application of symplectic integrators, a computer-aided analysis of the Sitnikov problem, the chaotic behavior of trajectories for the asteroidal resonances, and the resonant motion in the restricted three-body problem. Also discussed are the second order long-period motion of Hyperion, meteorites from the asteroid 6 Hebe, and least squares parameter estimation in chaotic differential equations.

  11. Rotating machinery - Dynamics; Proceedings of the 3rd International Symposium on Transport Phenomena and Dynamics of Rotating Machinery (ISROMAC-3), Honolulu, HI, Apr. 1-4, 1990

    NASA Astrophysics Data System (ADS)

    Kim, J. H.; Yang, W.-J.

    Topics addressed include rotordynamic software, blade loss dynamics of a magnetically supported rotor, flow visualization in a single simulated brush seal, an analytical investigation of a cryogenic journal bearing, vibration protection of aeration turbine gear motor, a simple procedure for assessing rotor stability, and stability of rotating cylindrical shells including nonlinear stiffening. Attention is also given to aeroelastic analysis of vertical axis wind turbines, an active chamber system for vibration control of rotating machinery, a computer system for multibearing rotor design, equations of motion of a flexible rotor with axially loose disc, and simulation research on the dynamic characteristics of a steam-injected gas turbine.

  12. Demonstration of oxygen-enriched air staging at Owens-Brockway glass containers. Quarterly report. Feb. 1, 1996--Apr. 30, 1996

    SciTech Connect

    1996-07-01

    Objective is to demonstrate use of a previously developed combustion modification technology to reduce NO{sub x} emissions from sideport regenerative container glass melters. Host furnace is an Owens- Brockway 6-port pair sideport furnace in Vernon CA producing 325- ton/d of amber container glass. Baseline NO{sub x} level is 4.0 lb/ton glass; an anticipated NO{sub x} reduction of 50% would lower this to below 2 lb/ton. With the OEAS operating on only one of the 6 ports, an overall NO{sub x} reduction of 8-10% was obtained, suggesting that an overall furnance NO{sub x} reduction of 50% can be achieved.

  13. AIAA/ASME/ASCE/AHS/ASC Structures, Structural Dynamics and Materials Conference, 33rd, Dallas, TX, Apr. 13-15, 1992, Technical Papers. Pt. 3 - Structural dynamics I

    SciTech Connect

    Not Available

    1992-01-01

    The present conference on structural dynamics encompasses finite-element analyses of rotorcraft vibration, spacecraft dynamics, dynamic analyses, rotor aeroelasticity, rotorcraft dynamics, damping, control analysis and experiments, and experimental dynamics and testing. Specific issues addressed include NASA/industry design-analysis methods for vibrations, controlling a large flexible structure to mimic a rigid one, the dynamic response of rapidly heated space structures, interval prediction in structural dynamic analysis, mode localization in computer disk drives, and a discrete transfer-matrix method for rotating beams. Also addressed are the dynamics of axially moving continua on an elastic foundation, stiffness and stress in a fluid-filled circular diaphragm, linear structure control by the modal force technique, directional filters for sensing 1D structural dynamics, and an adaptive multilevel substructuring method for efficient modeling of complex structures.

  14. A study of the striped bass in the marine district of New York State. Completion report 1 Apr 76-31 Mar 79

    SciTech Connect

    Young, B.H.

    1980-05-01

    Between April of 1976 and March of 1979, a total of 9,791 striped bass were netted from western Long Island Sound, the Hudson River and the heated plume at the Northport Power Station using beach seines and gill nets. Of these, 1,854 striped bass were collected in western Long Island Sound, 1,701 of which were tagged and released. Most of these fish were less than two years old. In the Hudson River, 7,920 young-of-the-year and yearling striped bass were collected; 1,017 of this collection were tagged and released. In addition, 17 striped bass were collected, tagged and released in the heated plume at the Northport Power Station.

  15. Effects of magnetic storm phases on F-layer irregularities from auroral to equatorial latitudes. Quarterly report, 1 Apr-30 Jun 92

    SciTech Connect

    Aarons, J.; Mendillo, M.

    1992-06-30

    The review of equatorial data relative to F-layer irregularities continued during this period with an emphasis in this quarter on the results of a long series of optical measurements. The study uses the largest optical data base yet obtained of equatorial airglow depletions to describe such observational features of irregularity plume onset and development under different seasonal and geomagnetic conditions. They are most interested in the data showing the extreme altitudes/latitudes reached by such effects.

  16. Smart materials fabrication and materials for micro-electro-mechanical systems; Symposium Proceedings, San Francisco, CA, Apr. 28-30, 1992

    NASA Technical Reports Server (NTRS)

    Jardine, A. Peter (Editor); Johnson, George C. (Editor); Crowson, Andrew (Editor); Allen, Mark (Editor)

    1992-01-01

    A conference on the rapidly developing fields of `smart materials' and micro-electro-mechanical systems produced papers in the areas of fabrication and characterization of ferroelectric thin films; polycrystalline silicon; optical, chemical, and biological sensors; thin film shape memory alloys; materials characterization; and alternative materials and applications.

  17. Evaluation of the efficacy of Rohm and Haas Ambergard XE-555 resin for decontamination of a biological simulant. Final report, Apr-Jul 91

    SciTech Connect

    Harvey, S.P.; Kutchey, C.M.; Whally, C.E.

    1992-01-01

    Our objective was to determine the efficacy of the Rohm and Haas Ambergard XE-555 decontaminant resin for the removal of Bacillus thuringiensis spores from four surfaces: rubber gloves, canteen covers, webbed belts, and canteens. The percentage of recoverable spores was compared between the same surfaces decontaminated with the XE-555 resin and laboratory paper towel. Results show that although there were some differences in the efficiency with which the paper towels and the resin pads removed spores from different surfaces, there was no evidence that the pads provided any significant degree of enhanced decontamination. The rationale for the comparison was that the paper towel and the resin pads should have similar ability to physically remove Bt spores from various surfaces. If the resin has any significant affinity for the spores or if it has any killing effect on them, correspondingly fewer living spores should be isolated from the surfaces decontaminated with the resin than with the paper towel.

  18. Alternative energy sources in fisheries and aquaculture; management of tropical fisheries, and aquaranching: ICLARM newsletter, volume 4, numbers 2-4. Report for Apr-Oct 81

    SciTech Connect

    Not Available

    1981-10-01

    These Newsletters have articles on: ADB-ICLARM Workshop on Alternative Energy; Working group recommendations on strategy, technology identification, and research priorities; Oil, fish, and the sun and the wind; Wind energy, hydropower, and heat pumps for aquaculture; Village integrated energy systems; Low energy fishing vessels-the use of sail power; Solar power for on-shore activities; Fuels from biomass - prospects for use in fishing communities; Why Sinarapan almost disappeared from Lake Buhi; Research and management for tropical multispecies fisheries; and Toward economic management of fisheries in China.

  19. Flammability and sensitivity of materials in oxygen-enriched atmospheres; Proceedings of the Fourth International Symposium, Las Cruces, NM, Apr. 11-13, 1989. Volume 4

    NASA Technical Reports Server (NTRS)

    Stoltzfus, Joel M. (Editor); Benz, Frank J. (Editor); Stradling, Jack S. (Editor)

    1989-01-01

    The present volume discusses the ignition of nonmetallic materials by the impact of high-pressure oxygen, the promoted combustion of nine structural metals in high-pressure gaseous oxygen, the oxygen sensitivity/compatibility ranking of several materials by different test methods, the ignition behavior of silicon greases in oxygen atmospheres, fire spread rates along cylindrical metal rods in high-pressure oxygen, and the design of an ignition-resistant, high pressure/temperature oxygen valve. Also discussed are the promoted ignition of oxygen regulators, the ignition of PTFE-lined flexible hoses by rapid pressurization with oxygen, evolving nonswelling elastomers for high-pressure oxygen environments, the evaluation of systems for oxygen service through the use of the quantitative fault-tree analysis, and oxygen-enriched fires during surgery of the head and neck.

  20. 20 ans après: a second mutation in MAOA identified by targeted high-throughput sequencing in a family with altered behavior and cognition

    PubMed Central

    Piton, Amélie; Poquet, Hélène; Redin, Claire; Masurel, Alice; Lauer, Julia; Muller, Jean; Thevenon, Julien; Herenger, Yvan; Chancenotte, Sophie; Bonnet, Marlène; Pinoit, Jean-Michel; Huet, Frédéric; Thauvin-Robinet, Christel; Jaeger, Anne-Sophie; Le Gras, Stéphanie; Jost, Bernard; Gérard, Bénédicte; Peoc'h, Katell; Launay, Jean-Marie; Faivre, Laurence; Mandel, Jean-Louis

    2014-01-01

    Intellectual disability (ID) is characterized by an extraordinary genetic heterogeneity, with >250 genes that have been implicated in monogenic forms of ID. Because this complexity precluded systematic testing for mutations and because clinical features are often non-specific, for some of these genes only few cases or families have been unambiguously documented. It is the case of the X-linked gene encoding monoamine oxidase A (MAOA), for which only one nonsense mutation has been identified in Brunner syndrome, characterized in a single family by mild non-dysmorphic ID and impulsive, violent and aggressive behaviors. We have performed targeted high-throughput sequencing of 220 genes, including MAOA, in patients with undiagnosed ID. We identified a c.797_798delinsTT (p.C266F) missense mutation in MAOA in a boy with autism spectrum disorder, attention deficit and autoaggressive behavior. Two maternal uncles carry the mutation and have severe ID, with a history of maltreatment in early childhood. This novel missense mutation decreases MAOA enzymatic activity, leading to abnormal levels of urinary monoamines. The identification of this new point mutation confirms, for the first time since 1993, the monogenic implication of the MAOA gene in ID of various degrees, autism and behavioral disturbances. The variable expressivity of the mutation observed in male patients of this family may involve gene–environment interactions, and the identification of a perturbation in monoamine metabolism should be taken into account when prescribing psychoactive drugs in such patients. PMID:24169519

  1. Fire hazard criteria for noise control products in underground coal mines. Open file report 28 Sep 79-5 Apr 83

    SciTech Connect

    Pettitt, M.R.; Giuntini, R.E.; Wessels, W.R.

    1983-05-01

    The development of fire hazard criteria for noise control products in underground coal mines are presented. Qualifying requisites of the criteria include maintaining miners' safety, allowing for maximum use of noise control products, and economic feasibility. The burning process is analyzed for its relationship to fire hazard criteria developed by the National Aeronautics and Space Administration and the Federal Aviation Administration, and the mine environment is analyzed in conjunction with the end-use applications of noise control products. Also, the interim fire hazard specification developed by the Mine Safety and Health Administration is appraised as it applies to end-use applications of noise control products. From these analyses and a literature survey, fire hazard criteria are developed that include an initial screening procedure that evaluates the level of flammability testing required.

  2. Cellular- and molecular- level responses after radiofrequency radiation exposure, alone or in combination with x rays or chemicals. Annual technical report, 1 Apr 91-31 Mar 92

    SciTech Connect

    Meltz, M.L.

    1992-07-30

    The focus of the first year's activities, at a time when a major recruitment of personnel was underway, revolved around: selection of the appropriate cell line for performing the mammalian cell mutagenicity studies; preliminary studies with the Balb/c 3T3 cell transformation assay; mutation spectrum analysis of the spontaneous mutants arising in AS52 and BH4 chinese hamster ovary (CHO) cell lines; liposome encapsulation studies of the polymer diazoluminomelanin (DALM); and redesign of the thermal control system originally constructed as a prototype for the Radiofrequency Radiation Division at USAF Armstrong Laboratory. Most importantly, although the original proposal called for the study of the possible mutagenic interaction of microwaves and ionizing radiation using the AS52 line of CHO cells, the results of the mutation spectrum analysis study led to the decision to alter future protocols to perform these studies with the BH4 cells; otherwise, the experiments would predominantly be measuring small deletion type mutations, and would not have enough sensitivity to pick up alterations of other types of mutation which might occur due to the microwave exposures. In addition, the liposome studies revealed the difficulty of encapsulating chemically synthesized DALM in this biological system; these studies will need to be furthered using other resources. The redesign and construction of a modified thermal control system was begun, allowing for one control unit to perform the temperature measurement and temperature control functions in two separate incubator systems.

  3. Mitigation of explosion bubble pulsation caused by the deep underwater detonation of a tapered charge. Final report 21 Apr-31 Oct 80

    SciTech Connect

    Thomsen, J.M.; Ruhl, S.F.

    1980-10-31

    The dynamics of the explosion bubble growth and collapse due to the underwater detonation of a 5.3-m-long tapered charge containing 454 kg of TNT are examined calculationally. The burst was 305 m below the sea surface in deep water. The calculational method, using a coupled Eulerian-Lagrangian finite-difference hydrodynamics computer code, was made credible by successfully calculating the explosion bubble dynamics of spherical TNT charges detonated at the same depth of burst. Results show the tapered charge explosion bubble exhibits characteristics that are very similar to an equal-weight spherical charge over the first bubble period. This implies that bubble pulses will be produced by tapered charge detonations at this depth and deeper. The bubble pulses emitted by deep tapered charge detonations are not characteristic of the underwater nuclear detonation that these charges are designed to simulate. In fact, for conventional charges, bubble reloading of models is severe, and can lead to their unplanned collapse. Three methods of tapered charge bubble pulse mitigation were examined: (1) injection of propellant gas into the bubble to prevent/cushion collapse, (2) dissipation of bubble energy through enhancement of turbulence at the first minimum by creating an asymmetric bubble, and (3) using an explosive that produces condensible/soluble detonation products, thereby allowing more rapid transfer of bubble energy to the water and preventing the creation of a substantial bubble pulse. Results show that 2 and 3 are promising methods of bubble pulse mitigation. Additional work must be done to quantify the effectiveness of these methods and produce specific test designs.

  4. Rotating machinery - Transport phenomena; Proceedings of the 3rd International Symposium on Transport Phenomena and Dynamics of Rotating Machinery (ISROMAC-3), Honolulu, HI, Apr. 1-4, 1990

    SciTech Connect

    Kim, J.H.; Yang, W.J.

    1992-01-01

    Topics discussed in these proceedings include turbine cooling heat transfer, rotating surfaces, curved ducts and rotating channels, flow in pumps, analytical and numerical methods, design and design methods, and multiphase flow and cavitation. Papers are presented on transient heat analysis of stator in air-cooled turbine generators, numerical evaluation of single central jet for turbine disk cooling, film condensation on a rotating cone, flows of a gas in an abruptly rotating cylinder, developing turbulent flow in a curved duct with strong secondary motion, effects of turn region treatments on pressure loss through sharp 180-deg bends, and examination of inlet surging in centrifugal pumps. Particular attention is given to the prediction of viscous flows in rotating machinery using Navier-Stokes techniques, two-dimensional transonic flow around VKI turbine cascade, the dynamic transfer matrix of a pump and its use in pumping system design, a fast CAE/CAD procedure for the optimum design of arbitrary impellers, particle dynamics and erosion in radial turbine guide vanes, sustained oscillations of pumped two-phase flow in a closed loop, and rotor/stator flow coupling in turbomachines.

  5. Investigation of methods for updating ionospheric scintillation models using topside in-situ plasma-density measurements. Rept. for 1 May 90-30 Apr 91

    SciTech Connect

    Secan, J.A.

    1991-05-15

    Modern military communication, navigation, and surveillance systems depend on reliable, noise-free transionospheric radio-frequency channels. They can be severely impacted by small-scale electron-density irregularities in the ionosphere, which cause both phase and amplitude scintillation. Basic tools used in planning and mitigation schemes are climatological in nature and thus may greatly over- and under-estimate the effects of scintillation in a given scenario. This report summarizes the results of the first year of a three-year investigation into the methods for updating ionospheric scintillation models using observations of ionospheric plasma-density irregularities measured by DMSP Scintillation Meter (SM) sensor. Results are reported from the analysis of data from a campaign conducted in January 1990 near Tromso, Norway, in which near coincident in-situ plasma-density and transionospheric scintillation measurements were made. Estimates for the level of intensity and phase scintillation on a transionospheric UHF radio link in the early-evening auroral zone were calculated from DMSP SM data and compared to the levels actually observed.

  6. Metallurgical coatings and thin films; Proceedings of the International Conference, 18th, San Diego, CA, Apr. 22-26, 1991. Vols. 1 & 2

    NASA Technical Reports Server (NTRS)

    Mcguire, Gary E. (Editor); Mcintyre, Dale C. (Editor); Hofmann, Siegfried (Editor)

    1991-01-01

    A conference on metallurgical coatings and thin films produced papers in the areas of coatings for use at high temperatures; hard coatings and deposition technologies; diamonds and related materials; tribological coatings/surface modifications; thin films for microelectronics and high temperature superconductors; optical coatings, film characterization, magneto-optics, and guided waves; and methods for characterizing films and modified surfaces.

  7. The investigation of the combined use of microbarometric and seismic data to detect and identify infrasonic signals. Semi-annual report No. 1, 1 Apr-30 Sep 81

    SciTech Connect

    Sorrells, G.G.

    1981-12-30

    There is a need to acquire an infrasonics monitoring capability to supplement existing atmospheric nuclear test surveillance systems. A research program to investigate the combined use of a three-component seismograph and a microbarograph to supply the desired monitoring capability is currently underway. A temporary observatory consisting of a five-element microbarograph array and a three-component, long-period seismograph system has been established near McKinney, Texas, to acquire the experimental data necessary to perform the investigation. Preliminary analysis of the data indicates that the infrasonic signal-to-noise ratio will be greater at the output of a vertical seismograph than at the output of a microbarograph in a frequency range extending roughly from 0.005 Hz to 0.05 Hz during intervals of atmospheric turbulence.

  8. Évolution de leucémies myéloïdes chroniques sous nilotinib après échec a l'imatinib

    PubMed Central

    Sawadogo, Salifo; Hien, Francis Michel; Ouédraogo, Macaire Sampawendé; Drabo, Youssouf Joseph

    2014-01-01

    C'est une étude observationnelle prospective ouverte: quatre leucémies myéloïdes chroniques résistant ou intolérant à l'Imatinib ont été traitées par le Nilotinib. Elles ont été incluses dans le programme GIPAP et suivies selon les recommandations de “European LeukemiaNet”. Trois ont un score de Sokal de haut risque et une de bas risque. Deux étaient hypertendues. Mises sous Nilotinib, il y a eu deux rémissions cytogénétiques complètes et deux échecs. Le traitement a été interrompu chez les deux rémissions complètes, l'un pour effet secondaire du Nilotinib et l'autre pour changement de pays. Les deux échecs sont dus à des résistances. Le Nilotinib réduisant la fréquence des mutations des leucémies myéloïdes chroniques à haut risque et risque intermédiaire, il serait judicieux d'utiliser ce produit en première intention dans ces cas - ci pour réduire la charge des examens complémentaires. Les pays à bas revenu confrontés à des problèmes de survie ont besoin de la solidarité mondiale pour prendre en charge les leucémies myéloïdes chroniques. PMID:25419280

  9. Analysis of ground-water contaminant transport with three-dimensional scaled models. Technical completion report, 1 May 88-30 Apr 89

    SciTech Connect

    Sill, B.L.

    1991-04-01

    A three dimensional scale model was designed and built to simulate the transport of a solute in the groundwater at a known location. The study was undertaken to further validate a new method of groundwater transport modeling which has been under development at Clemson University, using mixtures of cement, sand and water to simulate the subsurface matrix. By comparing field measurements with laboratory simulations, it was judged that transport times and concentrations were modeled satisfactorily.

  10. Monolithic microwave integrated circuits for sensors, radar, and communications systems; Proceedings of the Meeting, Orlando, FL, Apr. 2-4, 1991

    NASA Technical Reports Server (NTRS)

    Leonard, Regis F. (Editor); Bhasin, Kul B. (Editor)

    1991-01-01

    Consideration is given to MMICs for airborne phased arrays, monolithic GaAs integrated circuit millimeter wave imaging sensors, accurate design of multiport low-noise MMICs up to 20 GHz, an ultralinear low-noise amplifier technology for space communications, variable-gain MMIC module for space applications, a high-efficiency dual-band power amplifier for radar applications, a high-density circuit approach for low-cost MMIC circuits, coplanar SIMMWIC circuits, recent advances in monolithic phased arrays, and system-level integrated circuit development for phased-array antenna applications. Consideration is also given to performance enhancement in future communications satellites with MMIC technology insertion, application of Ka-band MMIC technology for an Orbiter/ACTS communications experiment, a space-based millimeter wave debris tracking radar, low-noise high-yield octave-band feedback amplifiers to 20 GHz, quasi-optical MESFET VCOs, and a high-dynamic-range mixer using novel balun structure.

  11. Hp-41CV flight performance advisory system (FPAS) for the E-2c, E-2B, and C-2A aircraft. Final technical report Apr-Jun 82

    SciTech Connect

    Ferrell, D.R.

    1982-06-01

    This report describes follow-on work performed under the auspices of AE 4900, Directed Studies in Aeronautical Engineering at the Naval Postgraduate School, to complement the original design of a Flight Performance Advisory System (FPAS) for the E-2C aircraft. The original design fulfilled the requirements of AE 3001, Aircraft Energy Conservation. AE 3001, offered in the Fall Quarter 1981, and conducted by Professor Allen E. Fuhs, was sponsored in part by the Naval Air Development Center (NADC). NADC desired to obtain the input of several fleet experienced aviators in order to design program code for the HP-41CV handheld, programmable calculator that would benefit pilots by providing them with fuel efficiency parameters in flight. Calculators were made available to the participants with the proviso that a completed and operable code for each aircraft be submitted by the end of the academic quarter, September 1981. Upon completion of the E-2C program, attempts were made to use the calculator in flight. One test was conducted informally in an E-2C at RVAW-110, NAS Miramar. Unfortunately, the voltage field induced in the cockpit by the main lobe of the radar passing over the cockpit caused the calculator to cease functioning. The need to devise shielding for the calculator, plus the desire to simplify and improve the existing code lead to this effort.

  12. Finite element analysis in fluids; Proceedings of the Seventh International Conference on Finite Element Methods in Flow Problems, University of Alabama, Huntsville, Apr. 3-7, 1989

    NASA Astrophysics Data System (ADS)

    Chung, T. J.; Karr, Gerald R.

    Recent advances in computational fluid dynamics are examined in reviews and reports, with an emphasis on finite-element methods. Sections are devoted to adaptive meshes, atmospheric dynamics, combustion, compressible flows, control-volume finite elements, crystal growth, domain decomposition, EM-field problems, FDM/FEM, and fluid-structure interactions. Consideration is given to free-boundary problems with heat transfer, free surface flow, geophysical flow problems, heat and mass transfer, high-speed flow, incompressible flow, inverse design methods, MHD problems, the mathematics of finite elements, and mesh generation. Also discussed are mixed finite elements, multigrid methods, non-Newtonian fluids, numerical dissipation, parallel vector processing, reservoir simulation, seepage, shallow-water problems, spectral methods, supercomputer architectures, three-dimensional problems, and turbulent flows.

  13. Finite element analysis in fluids; Proceedings of the Seventh International Conference on Finite Element Methods in Flow Problems, University of Alabama, Huntsville, Apr. 3-7, 1989

    NASA Technical Reports Server (NTRS)

    Chung, T. J. (Editor); Karr, Gerald R. (Editor)

    1989-01-01

    Recent advances in computational fluid dynamics are examined in reviews and reports, with an emphasis on finite-element methods. Sections are devoted to adaptive meshes, atmospheric dynamics, combustion, compressible flows, control-volume finite elements, crystal growth, domain decomposition, EM-field problems, FDM/FEM, and fluid-structure interactions. Consideration is given to free-boundary problems with heat transfer, free surface flow, geophysical flow problems, heat and mass transfer, high-speed flow, incompressible flow, inverse design methods, MHD problems, the mathematics of finite elements, and mesh generation. Also discussed are mixed finite elements, multigrid methods, non-Newtonian fluids, numerical dissipation, parallel vector processing, reservoir simulation, seepage, shallow-water problems, spectral methods, supercomputer architectures, three-dimensional problems, and turbulent flows.

  14. Radiosensibilité comparative des cellules épithéliales de trachée de rats après irradiation alpha in vitro

    NASA Astrophysics Data System (ADS)

    Kugel, C.; Bailly-Despiney, I.; Lagroye, I.; Poncy, J. L.

    1998-04-01

    The main risk in nuclear industry is the internal contamination after inhalation of high LET alpha emitters radionuclides. Main targets of pulmonary carcinogenesis are epithelial respiratory tract cells. An in vitro study was performed in order to determine if a difference in the radiosensitivity occured in epithelial cells from the trachea of two rat strains: Sprague Dawley and Wistar Furth-Fischer F344 after alpha exposure. The cells were irradiated after sedimentation in a specific well. The irradiation was performed using 241Am electrodeposited sources. The irradiation dosecloning efficiency relation was evaluated. A kinetic study of the proliferation and the clonal growth has also been investigated. La contamination interne par inhalation de radionucléides émetteurs alpha de haut TEL est le risque majeur de l'industrie nucléaire. Les cibles principales de la cancérogenèse pulmonaire sont les cellules épithéliales de l'appareil respiratoire. Une étude in vitro a été menée pour déterminer s'il existe une différence de radiosensibilité aux rayonnement alpha, des cellules épithéliales trachéales de deux souches de rats : Sprague Dawley et Wistar Furth-Fischer F344. Les cellules sont irradiées sédimentées au fond d'un puit spécifique à l'aide de sources électrodéposées de 241Am. L'évaluation de la survie cellulaire en fonction de la dose d'irradiation est complétée par un suivi cinétique de la formation et de la prolifération des colonies.

  15. Annual Performance Report 2010-2011. Bureau of Indian Education. Submitted February 1, 2012. Revised Clarification, April 17, 2012. APR Template-Part B (4)

    ERIC Educational Resources Information Center

    Bureau of Indian Education, 2012

    2012-01-01

    During SY 2010-2011, the Bureau of Indian Education (BIE) continued their efforts to improve the validity and reliability of data reporting. BIE data collections are dependent on school level entry (self-reporting) into the Native American Student Information System (NASIS) or into the Bureau's Annual Report from the schools. In addition,…

  16. American Society for Photogrammetry and Remote Sensing and ACSM, Annual Convention, Baltimore, MD, Mar. 29-Apr. 3, 1987, Technical Papers. Volume 1 - Remote sensing

    SciTech Connect

    Not Available

    1987-01-01

    Topics discussed in this volume include hydrospheric sciences; the applications of photointerpretation to resource assessments; earth-system science remote sensing research on global change; developments in workstations for image processing and geographic data handling; plant sciences; use of satellites for assessing forest cover; the techniques and applications of radar/sonar; and geography, land use, and land cover remote sensing. Papers are presented on the development of multidate estuarine water quality models using Landsat 2 and 4 MSS data, technical considerations in software design for scene catalog geographic searches, multistage remote sensing as a tool for Minnesota natural resources management, and modeling interactions between the terrestrial biosphere and the global atmosphere. Other papers include those on software and workstation design considerations for grass, the prinicipal component analysis of aerial video imagery, the definition of forest stand characteristics based on multiincidence angle SIR-B data, image-based SAR product simulation for analysis, and automated road network extraction from Landsat TM data.

  17. Applications of artificial intelligence 1993: Knowledge-based systems in aerospace and industry; Proceedings of the Meeting, Orlando, FL, Apr. 13-15, 1993

    NASA Technical Reports Server (NTRS)

    Fayyad, Usama M. (Editor); Uthurusamy, Ramasamy (Editor)

    1993-01-01

    The present volume on applications of artificial intelligence with regard to knowledge-based systems in aerospace and industry discusses machine learning and clustering, expert systems and optimization techniques, monitoring and diagnosis, and automated design and expert systems. Attention is given to the integration of AI reasoning systems and hardware description languages, care-based reasoning, knowledge, retrieval, and training systems, and scheduling and planning. Topics addressed include the preprocessing of remotely sensed data for efficient analysis and classification, autonomous agents as air combat simulation adversaries, intelligent data presentation for real-time spacecraft monitoring, and an integrated reasoner for diagnosis in satellite control. Also discussed are a knowledge-based system for the design of heat exchangers, reuse of design information for model-based diagnosis, automatic compilation of expert systems, and a case-based approach to handling aircraft malfunctions.

  18. La métaplasie osteoide de l'endomètre après une grossesse à terme: à propos d'un cas rare

    PubMed Central

    Jayi, Sofia; Bouguern, Hakima; Fatemi, Hind; Chaara, Hikmat; Laamarti, Afaf; Melhouf, Aabdelilah

    2013-01-01

    La métaplasie ostéoïde de l'endomètre (MOE) est une entité rare correspondant à la présence de tissu osseux dans l'endomètre, elle est le plus souvent diagnostiquée dans un contexte d'infertilité secondaire faisant suite à une grossesse interrompue. Même si plusieurs facteurs de risque sont répertoriés, sa physiopathologie reste mal connue et sa traduction clinique est très variable. Nous rapportons un cas de MOE apparu suite à un curetage pour rétention placentaire en post-partum. Le diagnostic a été suspecté par l'hystéroscopie et confirmé par l’étude anatomopathologique. A notre connaissance c'est le premier cas décrit suite à un accouchement à terme. A travers notre cas et à la lumière d'une revue de la littérature nous insistons sur les caractéristiques épidémiologiques, physiopathologiques, cliniques et para cliniques de cette entité rare, dont la connaissance est primordiale pour un diagnostic sûr et par conséquent un traitement adapté permettant souvent de récupérer la fertilité de la patiente. PMID:23898363

  19. International Conference on Finite Elements in Flow Problems, 7th, University of Alabama, Huntsville, Apr. 3-7, 1989, Selected Papers

    NASA Astrophysics Data System (ADS)

    1990-10-01

    Topics presented include the finite element analysis of confined turbulent swirling flows, compressible viscous flow calculations using compatible finite element approximations, the equilibrium and stability of Tokamaks, and a coupled finite element solution of biharmonic problems for vector potentials. Also presented are the Godunov-mixed methods for immiscible displacement, the iterative adaptive implicit-explicit methods for flow problems, finite element methods for one-dimensional combustion problems, and a technique for analyzing finite element methods for viscous incompressible flow.

  20. Approche à l’égard des nouveaux anticoagulants oraux en pratique familiale

    PubMed Central

    Douketis, James; Bell, Alan David; Eikelboom, John; Liew, Aaron

    2014-01-01

    Résumé Objectif Traiter des différentes éventualités pouvant survenir durant le suivi clinique et la prise en charge prolongés des patients prenant de nouveaux anticoagulants oraux (NACO). Qualité des données Aux fins de cette révision narrative (non systématique), nous avons effectué une recherche dans la base de données PubMed afin de relever des études cliniques récentes (soit de janvier 2008 à la semaine 32 de 2013) portant sur l’emploi des NACO pour la prévention des AVC dans les cas de fibrillation auriculaire et le traitement de la thromboembolie veineuse aiguë. Nous avons utilisé cette base de données probantes pour répondre à nos questions prédéfinies ayant trait à l’emploi des NACO en pratique générale. Message principal Le dabigatran et le rivaroxaban doivent être pris avec les repas afin de limiter la dyspepsie et de favoriser l’absorption, respectivement. Aucun NACO n’est accompagné de restrictions alimentaires, à l’exception de la consommation modérée d’alcool, et le rivaroxaban et l’apixaban peuvent être écrasés, au besoin. Les antiacides ne semblent pas perturber l’efficacité des NACO. Comme c’est le cas avec la warfarine, les patients traités aux NACO doivent éviter l’emploi prolongé d’anti-inflammatoires non stéroïdiens et d’antiplaquettaires. Chez les patients devant subir une chirurgie, il faut interrompre la prise de NACO de 2 à 5 jours avant l’intervention, en fonction du risque de saignement, et le traitement par le NACO doit être habituellement repris au moins 24 heures après la chirurgie. Il n’est habituellement pas nécessaire d’effectuer un test préopératoire de coagulation. Chez les patients qui développent un saignement, un saignement mineur ne justifie habituellement pas un test de laboratoire ni l’interruption du traitement par le NACO; dans le cas des saignements majeurs, il faut se concentrer sur l’application de mesures localisées visant à endiguer le

  1. Aspects épidémiologiques, diagnostiques et thérapeutiques des ostéosarcomes de l'enfant au CHU Aristide le Dantec de Dakar: à propos de 16 cas

    PubMed Central

    Ndour, Oumar; Alumeti, Desire Munyali; Fall, Mbaye; Fall, Aimée Faye; Diouf, Cheikh; Ndoye, Ndeye Aby; Ngom, Gabriel; Ndoye, Mamadou

    2013-01-01

    Le but de cette étude était de décrire les aspects épidémiologiques, diagnostiques et thérapeutiques des ostéosarcomes de l'enfant. Il s'agissait d'une étude rétrospective sur dix ans qui a colligé 16 dossiers d'ostéosarcome pris en charge au service de Chirurgie Pédiatrique de l'hôpital Aristide Le Dantec de Dakar. Les paramètres étudiés étaient le niveau d'instruction et le niveau socioprofessionnel des parents, l'origine géographique, l’âge, le sexe, les antécédents particuliers, le délai de consultation, les motifs de consultation, les signes physiques, les signes radiologiques, la biologie, les modalités thérapeutiques et l’évolution. Tous les patients avaient bénéficié d'un examen anatomopathologique qui a confirmé le diagnostic d'ostéosarcome. Pour la majeure partie de nos patients (58% des cas) les parents avaient un niveau d'instruction bas. L’âge moyen était de 11ans. Une prédominance masculine était retrouvée avec un sex-ratio de 3,25:1. Le délai de consultation moyen était de 16 mois. Le principal motif de consultation était la tuméfaction (10 cas). Huit patients avaient bénéficié d'un traitement traditionnel. La taille de la tumeur était supérieure à 10cm dans 14 cas. La localisation la plus fréquente était le genou (14 cas). La radiographie standard retrouvait dans 15 cas des images d'ostéolyse. Le bilan d'extension n'avait pas retrouvé de métastases. Les options thérapeutiques étaient dominées par l'amputation seule (43,75% des cas). La survie à 2 ans était de 17%. L'ostéosarcome atteint le plus souvent le garçon après l’âge de 10 ans. Sa prise en charge au Sénégal se heurte à d’énormes difficultés liées au retard diagnostique. La solution repose essentiellement sur une collaboration pluridisciplinaire. PMID:23720705

  2. Fiabilité test retest et validité de construit de la version française de L'Échelle fonctionnelle des membres inférieurs (ÉFMI), partie II

    PubMed Central

    René, Frédéric; Casimiro, Lynn; Tremblay, Manon; Chea, Phanny; Létourneau, Liliane; Silva, Megan; Stockwell, Victoria; Bergeron, Louis-Philippe

    2011-01-01

    RÉSUMÉ Introduction : Le Lower Extremity Functional Scale a été traduit en français en 2006. La version canadienne-française se nomme l'Échelle fonctionnelle des membres inférieurs (ÉFMI). La validité de construit et la fiabilité test-retest de l'ÉFMI n'ont pas encore été examinées. But : Examiner la fiabilité test-retest, la consistance interne et la validité de construit de l'ÉFMI. Méthodologie : Trente-quatre participants ayant subi une chirurgie ou une blessure à un membre inférieur ont rempli un questionnaire démographique et complété l'ÉFMI lors d'une évaluation initiale alors qu'ils étaient hospitalisés. Ils ont à nouveau complété l'ÉFMI dans un intervalle de 72 heures après la première évaluation. Le coefficient de corrélation intra-classe (CCI) et le coefficient kappa ont été utilisés afin d'examiner la fiabilité de type test-retest de l'ÉFMI. Le coefficient alpha Cronbach a été calculé pour évaluer la consistance interne. L'analyse factorielle a été utilisée pour examiner la validité de construit afin de déterminer le nombre de dimensions et leur signification respective. Résultats : Le CCI s'élève à une valeur de 0,92 [0,88–0,96] (IC: 95%). Le résultat du test α-Cronbach est de 0,95 (0,91–0,99) IC à 95%. L'analyse factorielle révèle que tous les éléments de l'ÉFMI se logent sur une dimension principale. Conclusion : Les résultats montrent que la version canadienne-française de l'ÉFMI est un outil unidimensionnel qui offre une fiabilité test-retest et une consistance interne excellentes. PMID:22379266

  3. Les séquelles de brûlures cervicales: aspects épidémiologique, clinique et thérapeutique au Maroc

    PubMed Central

    Rafik, Amine; Chabak, Hakim; Diouri, Mounia; Bahechar, Naïma; Chlihi, Abdessamad

    2015-01-01

    Les séquelles de brûlures cervicales représentent une entité fréquente des séquelles de brûlure, elles affectent la fonction, l'esthétique et l’état psychologique des patients et peuvent être de traitement difficile. Il s'agit d'une étude rétrospective étalée sur 5 ans de Mars 2009 au Octobre2014, réalisée au centre national des brûlés et de chirurgie plastique au CHU Ibn Rochd Casablanca. Nous avons analysé les caractéristiques épidémiologiqueset cliniques ainsi que les indications et les résultats thérapeutiques chez 300 patients présentant des rétractions cervicales post-brûlure, suivis dans notre formation. Les jeunes femmes étaient le plus souvent touchées (56%). la brûlure thermique par flamme de butane dans le cadre d'accident domestique était l’étiologie la plus fréquente (91%).75% des patients ont été pris en charge dans un délai de 18 mois après avoir présenté une incapacité fonctionnelle. Les brides cervicales modérées et sévères sont les plus fréquentes et représentent respectivement 60% et 16% des cas. Le traitement chirurgical a fait appel aux greffes cutanées dans 67%des cas, aux plasties locales dans 24%des cas et aux lambeaux dans 24% des cas, les résultats sont jugés bons dans 75%des cas et moyens dans 18% des cas, tandis que les cas restants (7%) ont nécessité une reprise chirurgicale. Le traitement des brides cervicales doit être associé à un programme de rééducation adapté, afin d'assurer la pérennité des résultats fonctionnels et esthétiques. PMID:26301017

  4. Leiomyosarcome de la langue: à propos d'un cas

    PubMed Central

    El jahd, Lahcen; Barhmi, Ismail; Tazi, Nabil; Rouadi, Sami; Abada, Reda; Roubal, Mohammed; janah, Abdelaziz; Mahtar, Mohammed

    2015-01-01

    Le léiomyosarcome primitif de la langue est une tumeur rare qui se développe aux dépens des fibres musculaires lisses. Le diagnostic est souvent difficile, fondé sur des caractéristiques immuno-histologiques particulières. L'objectif de ce travail est de décrire le profil épidémiologique, clinique, thérapeutique et évolutif du léiomyosarcome à travers un cas et une revue de la littérature. Nous rapportons le cas d'un homme âgé de 26 ans, sans antécédents pathologique particuliers, consultant pour une tuméfaction de la langue mobile évoluant depuis 2 ans. Une biopsie de la masse a été réalisée. L’étude anatomopathologique et immunohistochimique a confirmé le diagnostic d'un léiomyosarcome de la langue. L'IRM de la langue a objectivé un processus lesionnel intéressant la portion mobile et antérieur de la langue. Une exérèse de la masse a été réalisée. L'examen histologique a montré la présence d'un large néoplasme de 6 cm compatible à un léiomyosarcome peu différencié de la langue, de garde II selon la Fédération Nationale des Centres de Lutte Contre le Cancer (FNCLCC). Une radiothérapie externe sur la cavité buccale avec une dose de 65 Gy a été réalisée. Le patient a présenté 2 mois après la fin du traitement une adénopathie latéro-cervicale haute gauche (territoire II), il a bénéficié d'un curage ganglionnaire fonctionnel intéressant les territoires I, II et III puis réadressé en radiothérapie. Le léiomyosarcome de la langue est très rare surtout chez le sujet jeune. La chirurgie et la radiothérapie sont les armes thérapeutiques majeures. Le pronostic est très mauvais, Les facteurs les plus importants sont les marges d'exérèse et le grade. PMID:26600908

  5. Les cellulites cervico-faciales graves, facteurs et critères de gravité

    PubMed Central

    Lakouichmi, Mohammed; Tourabi, Khalid; Abir, Bader-eddine; Zouhair, Said; Lahmiti, Saad; Hattab, Nadia Mansouri

    2014-01-01

    La cellulite cervico-faciale grave est une infection polymicrobienne extensive et redoutable du tissu cellulo-adipeux de la face et du cou. L'objectif de cette étude est d'analyser certains facteurs favorisants et d’évaluer les critères de gravité en fonction des formes anatomo-cliniques. Il s'agit d'une étude rétrospective réalisée, entre janvier 2007 et décembre 2012, au service de chirurgie maxillo faciale de l'hôpital militaire Avicenne de Marrakech. Sur 147 cas de cellulites cervico-faciales pris en charge au niveau du service, 13 dossiers de cellulites graves ont été retenus. Neuf hommes (69%) et quatre femmes (31%) ont fait l'objet de cette étude, avec un âge moyen de 35 ans. Tous les patients ont été adressés pour prise en charge secondaire après avoir pris des anti-inflammatoires (AI). Sept cas (54%) étaient immunocompétents. La cause dentaire était soulevée chez neufs cas (69%). Cinq cas (38%) ont présenté une forme pseudo phlegmoneuse avec des signes compressifs des voies aéro-digestives. L'extension médiastinale a été observée chez quatre patients (31%). La forme nécrosante extensive a été retrouvée dans trois cas (23%). L’étude bactériologique, réalisée chez tous les patients, avait mis en évidence une flore microbienne mixte et polymorphe. Les cellulites cervico-faciales graves posent un réel problème de prise en charge thérapeutique. L'analyse des facteurs favorisants et l’évaluation des critères de gravité dans cette série ont permis de limiter une évolution défavorable. PMID:26113891

  6. Les fractures distales de la clavicule type II de Neer: plaque à crochet versus brochage transacromiale

    PubMed Central

    Mechchat, Atif; Elidrissi, Mohammed; Shimi, Mohammed; Elibrahimi, Abdelhalim; Elmrini, Abdelmajid

    2015-01-01

    Cette étude a été menée afin de faire une comparaison entre deux techniques chirurgicales différentes: la plaque à crochet et l'embrochage dans les fractures instables du quart externe de la clavicule. Nous avons mené une étude prospective entre 2009 et 2013, incluant deux groupes de patients: un premier groupe de 14 patients traités par plaque à crochet par voie d'abord antéro-inférieure, un second de 12 patients traités par brochage. Tous les patients ont été hospitalisés 24 h après la chirurgie et ont été suivi pendant 1 an. Nous avons comparé les résultats des deux techniques en étudiant: le temps opératoire, le saignement, délai de consolidation, la douleur et la fonction selon le score de constant. L'analyse statistique des résultats fonctionnels et radiologiques a montré la supériorité d'une technique par rapport à l'autre; ainsi l’âge moyen global était de 32,6 ans (+/- 13,7), le sex-ratio (H/F) était de 1. Le temps opératoire moyen est de 35 min pour la plaque à crochet contre 45 minutes pour le brochage, le délai moyen de consolidation était de 6,1 (+/-0,7) semaines dans le groupe traité par plaque vissée, et de 6 (+/-0,7) semaines dans le groupe traité par embrochage (p = 0,5), le score de Constant absolu moyen était respectivement de 86 (+/-10,4) et de 90,92 (+/-2,5) (p = 0,04). L'analyse uni variée a montré une association statistiquement significative entre les paramètres d’évaluation et les deux techniques chirurgicales étudiées. Par conséquent, l’étude a noté la supériorité de la plaque à crochet contre l'embroche dans les fractures instables du quart externe de la clavicule. PMID:26090053

  7. Le synovialosarcome de la sphère oto-rhino-laryngée: une localisation rare: à propos de deux cas

    PubMed Central

    Kouhen, Fadila; Afif, Mohammed; Benhmidou, Naoual; Rais, Fadoua; El kabous, Mustapha; Khmou, Mouna; Cherradi, Nadia; Majjaoui, Sanaa; Elkacemi, Hanan; Kebdani, Tayeb; Benjaafar, Noureddine

    2015-01-01

    La localisation ORL du synovialosarcome est rare représentant moins de 5% des tumeurs de la région. Sa prise en charge est multidisciplinaire reposant sur une chirurgie large et complète suivie d'une radiothérapie externe. Nous rapportons deux cas de synovialosarcome de l'oropharynx et du sinus maxillaire chez deux adultes jeunes traités par une chirurgie et une radiothérapie externe avec une bonne réponse locorégionale. PMID:26140075

  8. Adenomyose utérine, étude clinique et thérapeutique: à propos de 87 cas

    PubMed Central

    Kdous, Moez; Ferchiou, Monia; Zhioua, Fethi

    2015-01-01

    Le but de notre étude est l'analyse des différents aspects épidémiologiques, cliniques, paracliniques et thérapeutiques de l'adénomyose. Il s'agit d'une étude rétrospective sur 87 patientes ayant bénéficié d'une hystérectomie pour des raisons diverses (hors prolapsus) entre le 1er janvier 2000 et 31 décembre 2006 et dont l’étude histologique de la pièce opératoire a révélé la présence d'adénomyose. 586 hystérectomies (hors prolapsus) ont été réalisées pendant la même période d’étude, soit une fréquence de l'adénomyose sur pièce opératoire de 14.85%. L'age moyen de nos patientes est de 43.97 ans (extrêmes: 26-64 ans). 29.88% d'entres-elles sont ménopausées et 41.37% avaient des antécédents de traumatisme utérin. La symptomatologie a été dominée par les ménometrorragies (82.77%) et les douleurs pelviennes (71.22%). Le diagnostic préopératoire a été suspecté sur les données de l'hystéroscopie dans 63.22% des cas, de l'hystérographie dans 58.46% des cas et de l’échographie transvaginale dans 40.5% des cas. Une chirurgie radicale a été indiquée de première intention dans 57 cas, après échec du traitement médical dans 16 cas et après échec d'une réduction endométriale dans 14 cas. L'analyse histologique des pièces d'hystérectomie trouve des myomes associés dans 32.18% des cas, une hyperplasie de l'endomètre dans 13.79%, des polypes dans 5.74% et une atrophie de l'endomètre dans 3.44%. L'adénomyose, maladie énigmatique, échappe toujours à une stratégie thérapeutique bien codifiée, et demeure étroitement liée à l'hystérectomie. Son dépistage chez des femmes de plus en plus jeunes et à des stades moins avancés pourrait éviter l’évolution systématique vers les traitements radicaux. PMID:26834926

  9. Cystostomie percutanée à la pince de Kelly: indications, technique et résultats

    PubMed Central

    Diabaté, Ibrahima; Ouédraogo, Bouréima; Sow, Ibrahima; Bâ, Aliou

    2015-01-01

    Introduction La dérivation urinaire sus-pubienne est pratiquée dans différentes circonstances. Cette étude vise à décrire la technique de cystostomie percutanée (CPC) pratiquée à l'aide d'une pince de Kelly pour la pose d'une sonde de Foley, à définir les indications de cette technique et à rapporter les résultats. Méthodes Du 1er janvier 2005 au 31 décembre 2014, il a été réalisé 194 CPC à la pince de Kelly dans notre service, en urgence, sous anesthésie locale, chez des patients en rétention vésicale. Cette technique, dérivée de la cystostomie par ponction au trocart vise à placer dans la vessie une sonde de Foley après incision cutanée et aponévrotique (de 1 cm sur la ligne médiane, à 1,5 - 2 cm au-dessus de la symphyse pubienne) et la ponction vésicale à la pince de Kelly à travers cette incision. Résultats Les 194 patients étaient tous de sexe masculin, âgés en moyenne de 50 ans ± 21 (extrêmes de 17 ans et 86 ans). Les pathologies à l'origine des rétentions vésicales étaient: les rétrécissements urétraux (n=119), les hypertrophies bénignes de la prostate (n=47), les cancers de prostate (n=21), les traumatismes de l'urètre (n=7). Tous les patients ont été opérés avec succès par cette méthode et les suites ont été simples. Le temps de réalisation était de 6 minutes ± 1. Les sondes de Foley mises en place étaient de charrière 16 (n=59), charrière 18 (n=116) et charrière 20 (n=19). La cicatrisation du trajet de la CPC après l'ablation de la sonde de Foley n'a posée aucun problème chez 146 patients suivis, les 48 autres ayant été perdus de vue. Conclusion La CPC à la pince de Kelly est une technique simple, rapide et pas onéreuse. Ses indications sont les mêmes que pour toute CPC et elle représente une alternative à la cystostomie par chirurgie ouverte. PMID:26893798

  10. Faut-il continuer à infiltrer le scalp par un anesthésique local pour une craniotomie?

    PubMed Central

    Doumiri, Mouhssine; Motiaa, Youssef; Razine, Rachid; Amor, Morad; Moussaoui, Abdelmajid; Kabbaj, Saad; Maazouzi, Wajdi

    2015-01-01

    Introduction Le maintien de la stabilité hémodynamique est un objectif primordial de l'anesthésie pour craniotomie. Peu d’études ont prouvé l'efficacité de l'infiltration du scalp par un anesthésique local pour le maintien de la stabilité hémodynamique après l'incision. L'objectif de notre travail est d’évaluer l'influence de l'infiltration de la ligne d'incision du scalp par la lidocaïne à 0,5% adrénalinée sur les paramètres hémodynamiques après incision pour craniotomie supratentorielle. Méthodes Étude prospective en double aveugle réalisée au bloc opératoire de l'hôpital des spécialités de Rabat sur une période d'une année incluant 80 malades programmés pour craniotomie supratentorielle. Les malades étaient randomisés par tirage au sort en 2 groupes: Le groupe 1 était infiltré par 40 ml du sérum salé adrénaliné (1/200 000) et le groupe 2 était infiltré par 40 ml de la lidocaïne 0,5% adrénalinée (1/200 000). Le critère de jugement principal était la pression artérielle moyenne (PAM) après l'incision. L’étude statistique a fait appel aux tests t de student et l'U- mann-whitney. Une valeur de p <0.05 était considérée significative. Résultats L’étude a inclus 80 patients (40 hommes et 40 femmes). L’âge moyen était 42,33±14,76 ans. Le poids moyen était 71,58 ±10 kg. Le 3/4 des patients était ASA 1, seulement 25% étaient ASA2. La durée moyenne de la chirurgie était de 252,06±38,62 mn. Les deux groupes étaient comparables concernant l’âge, le sexe, le poids, la durée d'intervention, le type d'abord chirurgical, la dose totale du fentanyl reçue jusqu'a l'incision, ainsi que les paramètres hémodynamiques avant l'incision. Après l'incision la FC moyenne a augmenté dans les deux groupes: 80,53±7,72 bpm dans le groupe contrôle et 76,85±8,52 bpm dans le groupe lidocaïne. La différence d'augmentation de la FC entre les deux groupes était statistiquement significative (p = 0,047). L

  11. Anévrisme de l'artère splénique rompu dans l'estomac: traitement chirurgical après échec d'une tentative d'embolisation

    PubMed Central

    Lachhab, Imad; Benkabbou, Amine; Souadka, Amine; El Malki, Haj Omar; Mohsine, Raouf; Ifrine, Lahcen; Belkouchi, Abdelkader

    2015-01-01

    L'anévrisme de l'artère splénique (AAS) est une entité pathologique rare le plus souvent asymptomatique. Nous rapportons le cas d'un patient âgé de 60 ans, hypertendu qui s'est présenté aux urgences pour un épisode d'hématémèse sans retentissement hémodynamique. Un bilan complet comportant un Angioscanner abdominal a mis en évidence un anévrisme de l'artère splénique refoulant la paroi postérieure de l'estomac en avant. Le diagnostic d'anévrisme de l'artère splénique rompu dans l'estomac a été posé et un traitement endovasculaire à type d'embolisation par coils effectué. Au 5ème jour post embolisation, le patient nous a été référé pour une persistance de mélénas. Un traitement chirurgical a été décidé. La mise à plat de l'anévrisme a permis d’évacuer les coils et le thrombus. L'objectif de cette observation est de montrer que l'embolisation d'un AAS rompu dans l'estomac a été une cause de retard thérapeutique qui pourrait être fatal pour le patient. Le traitement de référence est la cure chirurgicale de l'AAS par voie conventionnelle sans rétablissement de la continuité artérielle splénique, sans splénectomie et avec suture de l'orifice digestif. PMID:26090024

  12. High resolution 10 mu spectrometry at different planetary latitudes. A practical Hadamard transform spectrometer for astronomical application. Final Report, 1 Sep. 1973 - 28 Apr. 1977. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Tai, M. H.; Harwit, M.; Melnick, G.; Dain, F. W.; Stasavage, G.; Briotta, D. A., Jr.; King, L. W.; Kameth, M.

    1977-01-01

    Infrared observations at different latitudes were studied in order to obtain spectra in the 10 micrometers region to understand differences in chemical composition or physical structure of the optical features. In order to receive such spectra of a rotating planet, simultaneous observations at different latitudes were made. A Hadamard transform spectrometer with 15 entrance slits was used to obtain 15 simultaneous spectra, at a resolution of 0.01 micrometers. The spectral band covered contained 255 spectral elements.

  13. Insights into the Regulation of DMSP Synthesis in the Diatom Thalassiosira pseudonana through APR Activity, Proteomics and Gene Expression Analyses on Cells Acclimating to Changes in Salinity, Light and Nitrogen

    PubMed Central

    Kettles, Nicola Louise; Kopriva, Stanislav; Malin, Gill

    2014-01-01

    Despite the importance of dimethylsulphoniopropionate (DMSP) in the global sulphur cycle and climate regulation, the biological pathways underpinning its synthesis in marine phytoplankton remain poorly understood. The intracellular concentration of DMSP increases with increased salinity, increased light intensity and nitrogen starvation in the diatom Thalassiosira pseudonana. We used these conditions to investigate DMSP synthesis at the cellular level via analysis of enzyme activity, gene expression and proteome comparison. The activity of the key sulphur assimilatory enzyme, adenosine 5′-phosphosulphate reductase was not coordinated with increasing intracellular DMSP concentration. Under all three treatments coordination in the expression of sulphur assimilation genes was limited to increases in sulphite reductase transcripts. Similarly, proteomic 2D gel analysis only revealed an increase in phosphoenolpyruvate carboxylase following increases in DMSP concentration. Our findings suggest that increased sulphur assimilation might not be required for increased DMSP synthesis, instead the availability of carbon and nitrogen substrates may be important in the regulation of this pathway. This contrasts with the regulation of sulphur metabolism in higher plants, which generally involves up-regulation of several sulphur assimilatory enzymes. In T. pseudonana changes relating to sulphur metabolism were specific to the individual treatments and, given that little coordination was seen in transcript and protein responses across the three growth conditions, different patterns of regulation might be responsible for the increase in DMSP concentration seen under each treatment. PMID:24733415

  14. AIAA/ASME/ASCE/AHS/ASC Structures, Structural Dynamics, and Materials Conference, 34th and AIAA/ASME Adaptive Structures Forum, La Jolla, CA, Apr. 19-22, 1993, Technical Papers. Pts. 1-6

    NASA Technical Reports Server (NTRS)

    1993-01-01

    Topics addressed include the prediction of helicopter component loads using neural networks, spacecraft on-orbit coupled loads analysis, hypersonic flutter of a curved shallow panel with aerodynamic heating, thermal-acoustic fatigue of ceramic matrix composite materials, transition elements based on transfinite interpolation, damage progression in stiffened composite panels, a direct treatment of min-max dynamic response optimization problems, and sources of helicopter rotor hub inplane shears. Also discussed are dynamics of a layered elastic system, confidence bounds on structural reliability, mixed triangular space-time finite elements, advanced transparency development for USAF aircraft, a low-velocity impact on a graphite/PEEK, an automated mode-tracking strategy, transonic flutter suppression by a passive flap, a nonlinear response of composite panels to random excitation, an optimal placement of elastic supports on a simply supported plate, a probabilistic assessment of composite structures, a model for mode I failure of laminated composites, a residual flexibility approach to multibody dynamics,and multilayer piezoelectric actuators.

  15. Extension to the dynamic modeling of the large angle magnetic suspension test fixture. M.S. Thesis - Old Dominion Univ., May 1995 Progress Report, 1 Nov. 1994 - 30 Apr. 1995

    NASA Technical Reports Server (NTRS)

    Foster, Lucas E.; Britcher, Colin P.

    1995-01-01

    The Large Angle Magnetic Suspension Test Fixture (LAMSTF) is a laboratory scale proof-of-concept system. The configuration is unique in that the electromagnets are mounted in a circular planar array. A mathematical model of the system had previously been developed, but was shown to have inaccuracies. These inaccuracies showed up in the step responses. Eddy currents were found to be the major cause of the modeling errors. In the original system, eddy currents existed in the aluminum baseplate, iron cores, and the sensor support frame. An attempt to include the eddy current dynamics in the system model is presented. The dynamics of a dummy sensor ring were added to the system. Adding the eddy current dynamics to the simulation improves the way it compares to the actual experiment. Also presented is a new method of determining the yaw angle of the suspended element. From the coil currents the yaw angle can be determined and the controller can be updated to suspend at the new current. This method has been used to demonstrate a 360 degree yaw angle rotation.

  16. High power lasers: Sources, laser-material interactions, high excitations, and fast dynamics in laser processing and industrial applications; Proceedings of the Meeting, The Hague, Netherlands, Mar. 31-Apr. 3, 1987

    NASA Technical Reports Server (NTRS)

    Kreutz, E. W. (Editor); Quenzer, Alain (Editor); Schuoecker, Dieter (Editor)

    1987-01-01

    The design and operation of high-power lasers for industrial applications are discussed in reviews and reports. Topics addressed include the status of optical technology in the Netherlands, laser design, the deposition of optical energy, laser diagnostics, nonmetal processing, and energy coupling and plasma formation. Consideration is given to laser-induced damage to materials, fluid and gas flow dynamics, metal processing, and manufacturing. Graphs, diagrams, micrographs, and photographs are provided.

  17. Steel bars and forgings, 0.50Cr 0.55Ni 0.25Mo (0.38 0.43C) (SAE 8740), heat treated, 125,000 psi (862 MPa) tensile strength (reaffirmed, Apr 1994). (SAE standard)

    SciTech Connect

    1988-10-01

    This specification covers an aircraft-quality, low-alloy steel in the form of bars and forgings. Primarily for parts, such as nuts, bolts, and screws, 1.50 inch (38.1 mm) and under in section thickness, requiring a minimum tensile strength of 125,000 (862 MPa). Alloy: 8740 UNS Number: G8740.

  18. AIAA/ASME/ASCE/AHS/ASC Structures, Structural Dynamics, and Materials Conference, 34th and AIAA/ASME Adaptive Structures Forum, La Jolla, CA, Apr. 19-22, 1993, Technical Papers. Pts. 1-6

    NASA Astrophysics Data System (ADS)

    Topics addressed include the prediction of helicopter component loads using neural networks, spacecraft on-orbit coupled loads analysis, hypersonic flutter of a curved shallow panel with aerodynamic heating, thermal-acoustic fatigue of ceramic matrix composite materials, transition elements based on transfinite interpolation, damage progression in stiffened composite panels, a direct treatment of min-max dynamic response optimization problems, and sources of helicopter rotor hub inplane shears. Also discussed are dynamics of a layered elastic system, confidence bounds on structural reliability, mixed triangular space-time finite elements, advanced transparency development for USAF aircraft, a low-velocity impact on a graphite/PEEK, an automated mode-tracking strategy, transonic flutter suppression by a passive flap, a nonlinear response of composite panels to random excitation, an optimal placement of elastic supports on a simply supported plate, a probabilistic assessment of composite structures, a model for mode I failure of laminated composites, a residual flexibility approach to multibody dynamics,and multilayer piezoelectric actuators.

  19. Migration intra-péritonéal d'un dispositif intra utérin diagnostiqué 20 ans après l'insertion: à propos d'un cas

    PubMed Central

    Bouzouba, Wail; Alaoui, Fatime Zahra Fdili; Jayi, Sofia; Bouguern, Hakima; Melhouf, Moulay Abdelilah

    2014-01-01

    Le dispositif intra-utérin (DIU) est une des méthodes contraceptives les plus efficaces et les plus utilisé à travers le monde: environ 100 millions d'utilisatrices. La perforation reste exceptionnelle âpres la pose d'un DIU cependant c'est une des complications les plus graves. Nous rapportant le cas d'une patiente de 49 ans, notion de pose de stérilet il y a 20 ans, suivie en oncologie pour un carcinome canalaire infiltrant du sein ayant bénéficiée d'un patey puis chimiothérapie adjuvante actuellement sous hormonothérapie, qui dans le cadre du bilan d'extension, un scanner thoraco-abdomino-pelvienne a objectivé la présence d'un DIU en sous hépatique. Sous guidage coelioscopique, on a réussie à retirer le DIU qui était enchâssé dans l’épiploon au niveau de la gouttière pariéto-colique droite. Nous insistons à travers cette observation et sous la lumière de la revue de la littérature sur l'efficacité et l'innocuité du DIU lorsque la technique et les indications sont rigoureusement respectées, mais aussi sur une des complications rarissime de la pose du DIU, et à mettre en évidence le rôle diagnostic et thérapeutique de la cœlioscopie dans la prise en charge de ces migrations. PMID:25184024

  20. Nécrose pariétale utérine partielle après capitonnage hémostatique au cours d'une hémorragie de la délivrance

    PubMed Central

    Alaoui, Fatima Zohra Fdili; Jayi, Sofia; Bouguern, Hakima; Melhouf, Moulayabdilah; Fatemi, Hinde El; Amarti, Afaf

    2013-01-01

    L'hémorragie de la délivrance reste la première cause de mortalité dans la majorité des pays y compris le Maroc. Sa prise en charge doit être multidisciplinaire, rapide, avec mise en ‘uvre de moyens médicaux et parfois chirurgicaux pour contrôler l'hémorragie. Les techniques de compression ou de cloisonnement utérins ont été peu évaluées mais diffusées rapidement dans le monde entier vu la facilité de leur réalisation; Néanmoins des complications secondaires ont été rapportées dans la littérature dont la nécrose utérine. Nous rapportons le cas d'une patiente de 33ans césarisée à 38 semaines d'aménorrhée pour utérus cicatriciel associé à une grossesse gémellaire avec inertie utérine. Un capitonnage hémostatique a été nécessaire pour contrôler l'hémorragie, l’évolution a été marquée par la survenue d'une nécrose partielle utérine confirmée histologiquement. Nous insistons à travers cette observation et sous la lumière de la revue de la littérature sur la nécessité d'un suivi post opératoire des patientes qui bénéficient de capitonnage hémostatique pour mieux documenter l'efficacité et les complications de cet acte chirurgical qui reste encore sous évalué. PMID:24009808

  1. 75 FR 75502 - Order Extending and Modifying Temporary Exemptions Under the Securities Exchange Act of 1934 in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-03

    ... Nos. 60372 (Jul. 23, 2009), 74 FR 37748 (Jul. 29, 2009) and 61973 (Apr. 23, 2010), 75 FR 22656 (Apr...); Securities Exchange Act Release Nos. 60373 (Jul. 23, 2009), 74 FR 37740 (Jul. 29, 2009) and 61975 (Apr. 23, 2010), 75 FR 22641 (Apr. 29, 2010) (temporary exemptions in connection with CDS clearing by...

  2. 31 CFR 351.30 - What are interest rates and monthly accruals for Series EE bonds with issue dates of May 1, 1997...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .... through Jan. Feb. or Aug May 1 Aug. through Jan Sep. through Feb. Mar. or Sep May 1 Sep. through Feb Oct. through Mar. Apr. or Oct May 1 Oct. through Mar Nov. through Apr. May or Nov May 1 May through Oct Jun.... through Sep. Apr. or Oct Nov. 1 Apr. through Sep May through Oct. May or Nov Nov. 1 Nov. through Apr...

  3. 31 CFR 351.30 - What are interest rates and monthly accruals for Series EE bonds with issue dates of May 1, 1997...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .... through Jan. Feb. or Aug May 1 Aug. through Jan Sep. through Feb. Mar. or Sep May 1 Sep. through Feb Oct. through Mar. Apr. or Oct May 1 Oct. through Mar Nov. through Apr. May or Nov May 1 May through Oct Jun.... through Sep. Apr. or Oct Nov. 1 Apr. through Sep May through Oct. May or Nov Nov. 1 Nov. through Apr...

  4. Les complications tardives de prothèse totale de la hanche: à propos de 42 cas

    PubMed Central

    Azarkane, Mohamed; Boussakri, Hassan; Shimi, Mohamed; Elibrahimi, Abdlehalim; Elmrini, Abdlemeji

    2013-01-01

    L'arthroplastie de la hanche est un moyen fiable dans le traitement des affections de la hanche. En lui rendant sa mobilité sa stabilité et son indolence. Cependant cette chirurgie prothétique expose au risque de la survenue des complications qui peuvent engager le pronostic fonctionnel. Nous avons réalisé une étude rétrospective sur une durée de 8 ans de janvier 2004 au janvier 2012 au service de traumatologie-orthopédie de CHU HASSAN II FEZ. Pendant cette période nous avons opéré 240 patients pour PTH. Après un recul moyen de 5 ans nous avons noté chez 42 (17,4%) patients une complication tardive. Nous noté 13 cas de descellement aseptique soit 5,4%. Cette complication a été survenue dans notre série sur une prothèse cimentée dans 8 cas et non cimentée dans 5 cas. Le traitement que nous avons adopté dans notre série a été une reprise de PTH sans greffe osseuse ni anneau de reconstruction dans 4 cas, reprise avec mise en place d'anneau de Kerboull dans 7 cas et reprise avec greffe osseuse et anneau de kerboull dans 2 cas. Nous avons trouvé 11 cas de sepsis tardive soit 4,6% des cas. Nous avons le diabète comme facteur de risque chez 3 malades. L'agent causal a été staphylococcus épdermidis dans 5 cas, colibacille dans 2 cas et association staphylococcus-BGN dans 1 cas. Les différentes modalités que nous avons utilisé pour traiter l'infection dans notre ont été un lavage simple, système d'irrigation-drainage et réimplantation simple en un seul temps ou en 2 temps avec couverture systématique par une antibiothérapie adaptée selon l'antibiogramme. Nous avons noté également 11 cas de fracture sur PTH intéressant dans tous les cas le fémur, nous avons traité ce type de fracture dans notre série par une tige fémorale prothétique longue dans 4 cas, une plaque vissée cerclée dans 3 cas et cerclage simple dans 4 cas. La consolidation a été obtenue chez 9 patients avec 2 cas de pseudarthrose. Nous avons noté 7 cas de

  5. Dilatation aigue de l'estomac: à propos de 02 cas et revue de la literature

    PubMed Central

    Touré, Alpha Oumar; Thiam, Ousmane; Cisée, Mamadou; Nduwimana, Diomede; Gueye, Mohamadou Lamine; Seck, Mamadou; Ka, Ousmane; Dieng, Madieng; Touré, Cheikh Tidiane

    2015-01-01

    La dilatation aiguë de l'estomac est une pathologie rare. Elle est classiquement observée en psychiatrie dans les troubles du comportement alimentaire. Le diagnostic préopératoire est difficile et fait appel à la radiologie. La mortalité liée aux complications varie entre 80% et 100%. Nous rapportons 2cas de dilatation aiguë de l'estomac prises en charge au service de Chirurgie Générale de l'Hôpital Aristide Le Dantec de Dakar dont l'une était compliquée de nécrose et l'autre d'une rupture gastrique. Il s'agissait de 2 patients dont l'un était de sexe masculin âgé de 32 ans et l'autre de sexe féminin âgée de 36 ans. Ils étaient reçus dans un tableau de douleurs abdominales aiguës et un état de collapsus cardiovasculaire. L'examen avait retrouvé un syndrome d'irritation péritonéale chez les 2 patients. A la biologie, on notait une anémie chez tous les patients. A la radiographie de l'abdomen sans préparation, on notait un pneumopéritoine massif chez le patient et un gros niveau hydro-aérique chez la patiente. Le diagnostic préopératoire était une péritonite par perforation d'organe creux chez le patient et une occlusion intestinale aiguë chez la patiente. Après une réanimation, la laparotomie avait permis de retrouver une dilatation énorme de l'estomac avec une large rupture au niveau de la petite courbure chez le patient et une dilatation importante de l'estomac avec une nécrose du fundus chez la patiente. Une suture de la petite courbure était réalisée chez le patient et une gastrectomie atypique fundique chez la patiente. Les suites opératoires étaient marquées par un décès chez le patient au deuxième jour post-opératoire et une sténose gastrique chez la patiente nécessitant une gastrectomie totale.La dilatation aiguë de l'estomac est une pathologie rare. Son diagnostic aux urgences est difficile car les signes ne sont pas spécifiques. Les formes compliquées donnent un tableau d'abdomen chirurgical aigu. L

  6. Cholestéatome de l'oreille moyenne - étude rétrospective à propos de 145 cas

    PubMed Central

    Bouaity, Brahim; Chihani, Mehdi; Nadour, Karim; Moujahid, Mountassir; Touati, Mliha; Darouassi, Youssef; Ammar, Haddou

    2014-01-01

    L'otite moyenne chronique cholestéatomateuse représente une entité fréquente et dangereuse en chirurgie otologique, mettant en jeu le pronostic fonctionnel auditif et exposant à des complications redoutables justifiant pleinement le recours exclusif à un traitement chirurgical et à un suivi post-opératoire rigoureux. Dans le but de mettre le point sur les caractéristiques épidémiologiques, cliniques, thérapeutiques et évolutives de cette pathologie, nous avons mené une étude rétrospective, étalée sur 11 ans et portant sur 145 cas de cholestéatome de l'oreille moyenne opérés au sein du service d'oto-rhino-laryngologie et chirurgie cervico-faciale de l'hôpital militaire Avicenne de Marrakech. PMID:25120876

  7. Plaie de l'artère sous-clavière gauche par un tournevis: à propos d'un cas

    PubMed Central

    Labsaili, Hicham; Makani, Said

    2014-01-01

    Nous rapportons le cas d'un patient présentant une plaie de l'artère sous-clavière gauche suite à un traumatisme par un tournevis. Il s'agit d'une lésion rare mais grave, qui entraine souvent des complications neurologiques et respiratoires pouvant être mortelles. Dans les pays en voie de développement, la chirurgie classique à ciel ouvert reste de premier recours. PMID:25400842

  8. 78 FR 42127 - Self-Regulatory Organizations; National Securities Clearing Corporation; Notice of Filing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-15

    .... Release No. 34-69313 (Apr. 4, 2013), 78 FR 21487 (Apr. 10, 2013). On April 19, 2013, NSCC filed Amendment... Amendment No. 1. Release No. 34-69620 (May 22, 2013), 78 FR 32292 (May 29, 2013). On June 11, 2013, NSCC... the proposal are completed. \\4\\ See Release No. 34-69451 (Apr. 25, 2013), 78 FR 25496 (May 1,...

  9. 76 FR 67099 - Forwarding of Asylum Applications to the Department of State

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-31

    ... corresponding regulations at 8 CFR 208.11. See 74 FR 15367 (Apr. 6, 2009). USCIS's revised regulations took... asylum applications filed with USCIS. See 74 FR 15367 (Apr. 6, 2009). As noted earlier, the EOIR.... See 74 FR 15367 (Apr. 6, 2009). Prior to these changes, USCIS requests for information on...

  10. 75 FR 75520 - Order Extending Temporary Conditional Exemptions Under The Securities Exchange Act of 1934 in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-03

    ... Release Nos. 60372 (Jul. 23, 2009), 74 FR 37748 (Jul. 29, 2009) and 61973 (Apr. 23, 2010), 75 FR 22656...); Securities Exchange Act Release Nos. 60373 (Jul. 23, 2009), 74 FR 37740 (Jul. 29, 2009) and 61975 (Apr. 23, 2010), 75 FR 22641 (Apr. 29, 2010) (temporary exemptions in connection with CDS clearing by...

  11. Etude de la flore bactérienne contaminant les téléphones mobiles avant et après la désinfection: comparaison entre les professionnels soignants de l'hôpital militaire d'instruction Mohammed V de Rabat et les témoins

    PubMed Central

    Uwingabiye, Jean; Moustanfii, Wafaa; Chadli, Meryem; Sekhsokh, Yassine

    2015-01-01

    Introduction L'objectif de notre travail était évaluer la contamination microbienne des téléphones mobiles utilisés par les personnels soignants des différents services de l'hôpital militaire d'instructions Mohammed V de Rabat et la comparer à celui d'une population témoin et aussi démontrer l'efficacité des solutions hydroalcoolique dans la désinfection de ces téléphones mobiles. Méthodes Il s'agit d'une étude descriptive transversale réalisée sur une période de 9 mois entre septembre 2010 et juin 2011, dans le service de bactériologie de l'hôpital militaire d'Instruction Mohammed V. Résultats L’étude bactériologique a été faite sur 240 téléphones mobiles dont 50% provenaient de personnels de sante. Le taux de contamination bactérienne de tous les téléphones mobiles était de 100%. Les cultures des bactéries isolées au niveau des téléphones mobiles du personnel médical étaient plus polymorphes que celles de la population témoin (p=0,028). Parmi 437 bactéries isolées: 223(51%) provenaient de téléphones de personnels de santé et 214(49%) de téléphones de la population témoin avec une différence qui n’était pas statistiquement significative(p>0,05) sauf pour les isolats de Staphylocoque à coagulase négative et Staphylococcus aureus. Les bactéries isolées étaient représentées par: Staphylocoque à coagulase (57,7%), Staphylococcus aureus (18,1%), Corynebacterium sp (18,8%), Bacillus sp (2,3%) et autres (2,2%). La différence entre la prévalence des bactéries isolées selon les services et les fonctions des personnels de santé n’était pas statistiquement significative (p>0,05). La désinfection des téléphones portables par la solution hydroalcoolique a réduit à 99,5% le nombre des colonies. Conclusion Ce travail montre que les téléphones portables pourraient jouer un rôle dans la transmission des infections nosocomiales et communautaires. Dans le cadre de prévention de ces risques, il faut sensibiliser les utilisateurs des téléphones mobiles l'importance du lavage des mains et l'utilisation des solutions hydro alcoolique pour désinfecter aussi bien les téléphones portables que les mains. PMID:26977234

  12. Le pronostic statural après une pseudo-puberté précoce par déficit en 11ß hydroxylase chez une fille de 7 ans: à propos d'un cas avec revue de la literature

    PubMed Central

    Latrech, Hanane; Gaouzi, Ahmed

    2015-01-01

    L'hyperplasie congénitale des surrénales par déficit en 11ß hydroxylase se voit dans 5 à 10% des cas et est diagnostiquée, habituellement, devant des signes de virilisation d'un nouveau né ou d'un fœtus 46 XX et plus tard devant une HTA avec une hypokaliémie. Le pronostic de taille chez ces patients est très souvent compromis. Nous rapportons le cas d'un déficit en 11ß hydroxylase chez une enfant âgée de 7 ans révélé par une pseudo- puberté précoce traitée par hydrocortisone. La survenue d'une puberté précoce centrale complique encore plus la situation par la mise en jeu du pronostic de taille finale et nécessitant une prise en charge thérapeutique particulière. PMID:26113905

  13. A study of tectonic activity in the Basin-Range Province and on the San Andreas Fault. No. 3: Kinematics of Great Basin intraplate extension from earthquake, geodetic and geologic information. Final Technical Report, 15 Apr. 1981 - 31 Jan. 1986 M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Eddington, P. K.

    1986-01-01

    Strain rates assessed from brittle fracture, associated with earthquakes, and total brittle-ductile deformation measured from geodetic data were compared to paleostrain from Quaternary geology for the intraplate Great Basin of the western United States. These data provide an assessment of the kinematics and mode of lithospheric extension that the western U.S. Cordillera has experienced in the last 5 to 10 million years. Strain and deformation rates were determined by the seismic moment tensor method using historic seismicity and fault plane solutions. Contemporary deformation of the Great Basin occurs principally along the active seismic zones. The earthquake related strain shows that the Great Basin is characterized by regional E-W extension at 8.4 mm/a in the north that diminishes to NW-SE extension of 3.5 mm/a in the south. Zones of maximum extension correspond to belts of shallow crust, high heat flow, and Quaternary basaltic volcanism, suggesting that these parameters are related through an effect such as a stress relaxation allowing bouyant uplift and ascension of magmas.

  14. Evaluation des résultats après traitement des lésions intra épithéliales du col utérin par la cryothérapie: étude préliminaire au Centre Hospitalier Universitaire de Yaoundé: A propos de 21 cas

    PubMed Central

    Ndoua, Claude Cyrille Noa; Tebeu, Pierre Marie; Kemfang, Jean Dupont; Kasia, Jean Marie

    2015-01-01

    Nous rapportons les résultats d'une série de 21 cas de prise en charge par cryothérapie de lésions intra-épithéliales cervicales au Centre Hospitalier et Universitaire (CHU) de Yaoundé. Notre objectif principal était d’évaluer les résultats préliminaires de la prise en charge des lésions précancéreuses éligibles pour la cryothérapie. Il s'agissait d'une étude transversale descriptive qui s'est étalée sur 24 mois. Etaient inclus dans l’étude toutes les femmes traitées par cryothérapie. Nous avons exclu les patientes traitées par une autre méthode, les patientes perdues de vue et les dossiers incomplets. Le statut cervical a été déterminé à 6 semaines, 6 mois et 12 mois. Les complications précoces et tardives ont également été répertoriées. Au total 95.2% des lésions étaient cicatrisées à 6 semaines. A 6 mois, toutes les lésions avaient disparu et au 12ème mois, la guérison était effective chez 95.2% des patientes. Les saignements et l'hydrorrhée étaient les principales complications tardives avec des fréquences respectives de 66.7% et 95.2%. Aucun cas de sténose cervicale n'a été répertorié. La cryothérapie peut être utilisée comme méthode de traitement pour des lésions précancéreuses du col. PMID:26140068

  15. Recognition of Anterior Peritoneal Reflections and Their Relationship With Rectal Tumors Using Rectal Magnetic Resonance Imaging

    PubMed Central

    Yiqun, Sun; Tong, Tong; Fangqi, Liu; Sanjun, Cai; Chao, Xin; Yajia, Gu; Ye, Xu

    2016-01-01

    Abstract Our goal was to explore the factors influencing the visualization of anterior peritoneal reflections (APRs) using rectal MRI. We evaluated the usefulness of rectal MRI in measuring the distance from the anal verge to the APR and determining the relationship between the APR and the rectal tumor. Clinical and imaging data from 319 patients who underwent surgery after MRI examination between October 2010 and December 2013 were retrospectively analyzed. The distance from the anal verge to the APR and the relationship between the APR and the location of the rectal tumor was evaluated. analysis of variance, logistic regression, independent samples t tests, and Kappa tests were used for statistical analysis. The APR was visible in 283 of 319 cases using rectal MRI. The APR was more readily observed in patients who were older than 58 years (P = 0.046), in patients whose subcutaneous fat thicknesses were >22.2 mm (P = 0.004), in patients with nondistended bladders (P = 0.001), and in those with an anteversion of the uterus (P = 0.001). There was a significant difference between the distance from the anal verge to the APR between females (10.4 ± 1.1 cm) and males (10.0 ± 1.2 cm; P = 0.014). The accuracy in predicting tumor location with respect to the APR was 70%, 50%, 98.2%, respectively for patients with tumors located above, at, and below the APR (compared with the location determined during surgery). Most of the APRs were visible using rectal MRI, whereas certain internal factors influence visualization. Rectal MRI could be a useful tool for evaluating the distance from the anal verge to the APR and relationship between rectal tumors and the APR. PMID:26945377

  16. Compression médullaire d'origine métastatique

    PubMed Central

    Bouhafa, Touria; Elmazghi, Abderrahman; Masbah, Ouafae; Hassouni, Khalid

    2014-01-01

    La compression médullaire d'origine métastatique est une complication neurologique fréquente du cancer. C'est une urgence diagnostique et thérapeutique qui nécessite une prise en charge rapide et efficace. L'imagerie par résonnance magnétique (IRM) constitue l'examen de choix pour l'exploration de l'ensemble de la moelle. La prise en charge thérapeutique doit être multidisciplinaire incluant la corticothérapie, la radiothérapie et la chirurgie. PMID:25829974

  17. Entwicklung und Evaluation einer Kalibrierungsmethode für 3D-Ultraschall

    NASA Astrophysics Data System (ADS)

    Bergmeir, Christoph; Seitel, Mathias; Frank, Christian; de Simone, Raffaele; Meinzer, Hans-Peter; Wolf, Ivo

    Wir stellen eine Methode zur Kalibrierung einer 3D-Ultraschallsonde vor. Für Anwendungen in der minimalinvasiven Chirurgie wird die Ultraschallsonde mit einem Trackingsystem verbunden, um dem Aufnahmevolumen eine definierte räumliche Lage zu geben. Die Kalibrierung bringt die Koordinatensysteme des Trackingsystems und des Ultraschallbildes zur Deckung. Hierzu wird ein bekanntes Objekt, das Phantom, aufgenommen und im Ultraschallbild lokalisiert. Die Kalibrierungstransformation wird dann durch ein Verfahren der Hand-Auge-Kalibrierung errechnet. Ein oft übliches Anbringen zusätzlicher Trackingssensoren am Phantom ist damit nicht nötig, was die Kalibrierungsprozedur vereinfacht.

  18. Curiethérapie dans le traitement palliatif du cancer de l’œsophage

    PubMed Central

    Toulba, Ahmedou; Bakkali, Hanae; Boutayeb, Salwa; Kebdani, Tayeb; Ahid, Samir; Benjaafar, Noureddine

    2015-01-01

    Les patients atteints du cancer de l’œsophage ont souvent une maladie localement avancée, la dysphagie est le symptôme majeur chez la plupart de ces patients, plusieurs modalités thérapeutiques ont été utilisées pour améliorer cette dysphagie. Le but de ce travail est d’étudier l'efficacité et la tolérance de la curiethérapie haut débit de dose (HDR) endo-luminale dans le traitement palliatif des cancers de l’œsophage inopérable. Sur une période de 15 ans, l’étude a inclus les patients atteints de cancer de l’œsophage inopérable et/ou métastatique avec une dysphagie, sans extension à l'hypopharynx ou a la trachée et qui ont bénéficié d'une curiethérapie HDR avec ou sans radiothérapie externe à visée palliative. Au total 46 patients ont été inclus dans l’étude, 58,7% étaient des hommes, 42,2% avaient une dysphagie grade 2 et 37,8% étaient aphagiques, 78,6% des patients étaient performance satus PS 2, l'amaigrissement à été trouvé chez 81,4%, la localisation de la tumeur était surtout au niveau du tiers moyen et inférieur dans 97,8%, la hauteur médiane de la tumeur était de 7 cm (5,5-9), le carcinome épidermoïde était le type histologique le plus fréquent chez 31 patients (70,5%). Après un médiane de suivi de 5 mois, l'amélioration de la dysphagie a été retrouvée chez 76% des malades (p1]. L′incidence la plus élevée est observée dans certains pays notamment en Asie et en Afrique, et l′incidence dans les pays développés occidentaux est en augmentation [2]. Selon le registre du cancer de Rabat 2006-2008, le cancer de l’œsophage est rare et constitue 1,5% de tous les cancers chez l'homme [3]. Le taux de survie globale à 5 ans est de 8%, avec 80% des décès liés à l’évolution locale de la maladie [4]. Pour la minorité des patients avec une maladie localisée, le traitement par radiochimiothérapie concomitante avec ou sans chirurgie permet une amélioration de la survie [5]. Plus de 50

  19. Angelica polymorpha Maxim Induces Apoptosis of Human SH-SY5Y Neuroblastoma Cells by Regulating an Intrinsic Caspase Pathway.

    PubMed

    Rahman, Md Ataur; Bishayee, Kausik; Huh, Sung-Oh

    2016-02-01

    Angelica polymorpha Maxim root extract (APRE) is a popular herbal medicine used for treating stomachache, abdominal pain, stomach ulcers, and rheumatism; however the effect of APRE on cancer cells has not yet been explored. Here, we examined APRE cytotoxicity seen on target neuroblastoma cells (NB) using cell viability assays, DAPI visualization of fragmented DNA, and Western blotting analysis of candidate signaling pathways involved in proliferation and apoptosis. We demonstrated that APRE reduced cell viability in NB to a greater extent than in fibroblast cells. In addition, we found that APRE could inhibit the three classes of MAPK proteins and could also down-regulate the PI3K/AKT/GSK-3β activity all being relevant for proliferation and survival. APRE could also up-regulate Bax expression and down-regulate Bcl-2 and Mcl-1. With APRE treatment, depolarization of mitochondria membrane potential and activation of caspase-3 was demonstrated in the SH-SY5Y cells. We could not found increased activity of death receptor and caspase-8 as markers of the extrinsic apoptosis pathway for the APRE treated cells. In presence of a caspase-3 siRNA and a pan-caspase inhibitor, APRE could not reduce the viability of NB cells to a significant degree. So we predicted that with APRE, the intrinsic pathway was solely responsible for inducing apoptosis as we also showed that the non-caspase autophagy pathway or ER stress-ROS mediated pathways were not involved. These findings demonstrate that an intrinsic mitochondria-mediated apoptosis pathway mediates the apoptotic effects of APRE on SH-SY5Y cells, and that APRE shows promise as a novel agent for neuroblastoma therapy. PMID:26674967

  20. Angelica polymorpha Maxim Induces Apoptosis of Human SH-SY5Y Neuroblastoma Cells by Regulating an Intrinsic Caspase Pathway

    PubMed Central

    Rahman, Md. Ataur; Bishayee, Kausik; Huh, Sung-Oh

    2016-01-01

    Angelica polymorpha Maxim root extract (APRE) is a popular herbal medicine used for treating stomachache, abdominal pain, stomach ulcers, and rheumatism; however the effect of APRE on cancer cells has not yet been explored. Here, we examined APRE cytotoxicity seen on target neuroblastoma cells (NB) using cell viability assays, DAPI visualization of fragmented DNA, and Western blotting analysis of candidate signaling pathways involved in proliferation and apoptosis. We demonstrated that APRE reduced cell viability in NB to a greater extent than in fibroblast cells. In addition, we found that APRE could inhibit the three classes of MAPK proteins and could also down-regulate the PI3K/AKT/GSK-3β activity all being relevant for proliferation and survival. APRE could also up-regulate Bax expression and down-regulate Bcl-2 and Mcl-1. With APRE treatment, depolarization of mitochondria membrane potential and activation of caspase-3 was demonstrated in the SH-SY5Y cells. We could not found increased activity of death receptor and caspase-8 as markers of the extrinsic apoptosis pathway for the APRE treated cells. In presence of a caspase-3 siRNA and a pan-caspase inhibitor, APRE could not reduce the viability of NB cells to a significant degree. So we predicted that with APRE, the intrinsic pathway was solely responsible for inducing apoptosis as we also showed that the non-caspase autophagy pathway or ER stress-ROS mediated pathways were not involved. These findings demonstrate that an intrinsic mitochondria-mediated apoptosis pathway mediates the apoptotic effects of APRE on SH-SY5Y cells, and that APRE shows promise as a novel agent for neuroblastoma therapy. PMID:26674967

  1. Experiment 2039 – Diagnostic Logging in EE-3

    SciTech Connect

    Dash, Zora V.; Grigsby, Charles O.; Murphy, Hugh D.

    1984-06-19

    Experiment 2039, diagnostic logging in EE-3, was conducted in two parts. Part A, temperature and collar locator surveys while injecting water was run from ~16:00, 4-Apr-84 through ~11:00, 5-Apr-84. Part B, tracer surveys, run from ~8:15 - 21:00, 6-Apr-84. The purpose of the surveys was to determine fluid entry locations in the open hole sections of EE-3

  2. Usage Statistics: MedlinePlus

    MedlinePlus

    ... Oct-Dec-98 682,215 53,071 Jan-Mar-99 627,997 62,638 Apr-Jun-99 ... Dec-99 2,836,277 147,131 Jan-Mar-00 3,593,336 190,669 Apr-Jun- ... Dec-00 12,856,799 992,647 Jan-Mar-01 16,329,501 1,196,030 Apr- ...

  3. Usage Statistics

    MedlinePlus

    ... Oct-Dec-98 682,215 53,071 Jan-Mar-99 627,997 62,638 Apr-Jun-99 ... Dec-99 2,836,277 147,131 Jan-Mar-00 3,593,336 190,669 Apr-Jun- ... Dec-00 12,856,799 992,647 Jan-Mar-01 16,329,501 1,196,030 Apr- ...

  4. Short-term Outcomes of an Extralevator Abdominoperineal Resection in the Prone Position Compared With a Conventional Abdominoperineal Resection for Advanced Low Rectal Cancer: The Early Experience at a Single Institution

    PubMed Central

    Park, Seungwan; Hur, Hyuk; Min, Byung Soh

    2016-01-01

    Purpose This study compared the perioperative and pathologic outcomes between an extralevator abdominoperineal resection (APR) in the prone position and a conventional APR. Methods Between September 2011 and March 2014, an extralevator APR in the prone position was performed on 13 patients with rectal cancer and a conventional APR on 26 such patients. Patients' demographics and perioperative and pathologic outcomes were obtained from the colorectal cancer database and electronic medical charts. Results Age and preoperative carcinoembryonic antigen (CEA) level were significantly different between the conventional and the extralevator APR in the prone position (median age, 65 years vs. 55 years [P = 0.001]; median preoperative CEA level, 4.94 ng/mL vs. 1.81 ng/mL [P = 0.011]). For perioperative outcomes, 1 (3.8%) intraoperative bowel perforation occurred in the conventional APR group and 2 (15.3%) in the extralevator APR group. In the conventional and extralevator APR groups, 12 (46.2%) and 6 patients (46.2%) had postoperative complications, and 8 (66.7%) and 2 patients (33.4%) had major complications (Clavien-Dindo III/IV), respectively. The circumferential resection margin involvement rate was higher in the extralevator APR group compared with the conventional APR group (3 of 13 [23.1%] vs. 3 of 26 [11.5%]). Conclusion The extralevator APR in the prone position for patients with advanced low rectal cancer has no advantages in perioperative and pathologic outcomes over a conventional APR for such patients. However, through early experience with a new surgical technique, we identified various reasons for the lack of favorable outcomes and expect sufficient experience to produce better peri- or postoperative outcomes. PMID:26962531

  5. Arthrose due au genu varum: traitement par osteotomie tibiale de valgisation

    PubMed Central

    Moussa, Abdou Kadri; Lukulunga, Loubet Unyendje; Mahfoud, Mustapha; El Bardouni, Ahmed; Ismail, Farid; Kharmaz, Mohamed; Berrada, Mohammed Saleh; El Yaacoubi, Moradh

    2014-01-01

    Le traitement du genu varum est le plus souvent conservateur (ostéotomie tibiale de valgisation) permettant de corriger le trouble architectural afin de rétablir l'axe physiologique du membre inférieur. Le but de l’étude était d’évaluer les résultats du traitement et comparer à ceux de la littérature. Il s'est agi d'une étude rétrospective portant sur des patients présentant un genu varum qui s'est déroulée dans le Service de Chirurgie Orthopédique et Traumatologie de CHU Ibn SINA de RABAT, sur une période de 9 ans (2000 au 31 Décembre 2008). Nous avons inclus dans notre étude: les patients qui avaient un genu-varum clinique avec examen radiographique standard ainsi qu'un pangonogramme; traités par différents procédés d'ostéotomie tibiale de valgisation; avec un suivis d’ au moins deux ans. Nos critères d’évaluation ont été appréciés selon le score HSS. Nous avons colligé 115 cas de genu-varum par ostéotomie de valgisation. L’âge de nos patients variait entre 40 et 69 ans, avec une moyenne de 53 ans. Le pic de fréquence se situait entre 52et 63 ans. Le sexe féminin prédominait avec 87 cas (75,6%) avec un sex ratio 3,1. Un Indice de masse corporelle supérieur à 30 a été noté dans 44 cas (38%). Quant aux antécédents chirurgicaux,18 patients de la série (soit 14%) ont été opérés pour le genu varum d'un autre genou. Le délai de consultation a varié entre 4 mois à 6 ans, avec une moyenne de 2 ans. La douleur était le principal motif de consultation et était de siège médial dans 70% des cas et bicompartimental dans 30% cas. Il s'agissait d'une douleur mécanique dans 76% des cas, mixte 21% des cas et inflammatoire 4% des cas. La déformation du genou appréciée par l’écart intercondylien a été en moyenne de 8,7 cm avec des extrêmes de 3 cm et 33cm. Le bilan de l'imagerie médicale reposait essentiellement sur les radiographies standards du genou de face et de profil, ainsi que la goniométrie. Ces

  6. 76 FR 25366 - Notice of Submission of Proposed Information Collection to OMB Housing Opportunities for Persons...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-04

    ... for Persons With AIDS (HOPWA) Program: Competitive Grant Application; Annual Progress Report (APR) for...: Housing Opportunities for Persons with AIDS (HOPWA) Program: Competitive Grant Application;...

  7. Interleukin-6-Specific Activation of the C/EBPδ Gene in Hepatocytes Is Mediated by Stat3 and Sp1

    PubMed Central

    Cantwell, Carrie A.; Sterneck, Esta; Johnson, Peter F.

    1998-01-01

    C/EBPδ (CCAAT/enhancer binding protein δ) has been implicated as a regulator of acute-phase response (APR) genes in hepatocytes. Its expression increases dramatically in liver during the APR and can be induced in hepatic cell lines by interleukin-6 (IL-6), an acute-phase mediator that activates transcription of many APR genes. Here we have investigated the mechanism by which C/EBPδ expression is regulated by IL-6 in hepatoma cells. C/EBPδ promoter sequences to −125 bp are sufficient for IL-6 inducibility of a reporter gene and include an APR element (APRE) that is essential for IL-6 responsiveness. DNA binding experiments and transactivation assays demonstrate that Stat3, but not Stat1, interacts with this APRE. Two Sp1 sites, one of which is adjacent to the APRE, are required for IL-6 induction and transactivation by Stat3. Thus, Stat3 and Sp1 function cooperatively to activate the C/EBPδ promoter. Replacement of the APRE with Stat binding elements (SBEs) from the ICAM-1 or C/EBPβ promoter, both of which recognize both Stat1 and Stat3, confers responsiveness to gamma interferon, a cytokine that selectively activates Stat1. Sequence comparisons suggest that the distinct Stat binding specificities of the C/EBPδ and C/EBPβ SBEs are determined primarily by a single base pair difference. Our findings indicate that the cytokine specificity of C/EBPδ gene expression is governed by the APRE sequence. PMID:9528783

  8. René Leriche and “Philosophy of Surgery” in the light of contemporary medical ethics

    PubMed Central

    Akça, Tamer; Aydın, Süha

    2013-01-01

    Prof. Dr. René Leriche was a famous French surgeon who lived between 1879 and 1955. After working as a vascular surgeon in Lyon, he was appointed professor at the University of Strasbourg in 1924 and later the Paris Collége de France in 1937. Leriche had proposed vascular patches as the ideal treatment for obliterated vascular segments and advocated the necessity of sympathectomy in arterial diseases in the 1920s. He defined “Leriche Syndrome” in 1923 which is known by his name and which develops as a result of incomplete obstruction of the aortic bifurcation. René Leriche wrote a monograph entitled “La Chirurgie de la Douleur-Pain Surgery” in 1940 and he also became a pioneer in the sympathectomy procedure for pain treatment. René Leriche focused on topics that must be remembered again today, including surgery advanced into science, the physiological basis of surgery, research methods, as well as issues such as business technology, humanity in surgery, surgical essence and surgeon’s qualifications in the book entitled “La Philosophie de la Chirurgie-Philosophy of Surgery” that he wrote in 1951. In this review, the issues that Prof. Dr. René Leriche addressed in middle of the 20th century were revised in the light of contemporary medical ethics. PMID:25931863

  9. History of the ISS/SIC: Antoine Depage, one of the founders of the ISS/SIC.

    PubMed

    Van Hee, R

    2002-10-01

    Antoine Depage, born near Brussels in 1862, was one of the founders and first Secretary General of the Société Internationale de Chirurgie (ISS-SIC). After an excellent medical education at the Free Brussels University, he became professor at the same university at the age of 27. Surgically trained by Prof. Thiriar, he became one of the leading Belgian surgeons at the end of the nineteenth century, and he published more than 100 articles in national and international journals. In 1907 he founded a school for nurses in Brussels, to be directed by Edith Cavell. He also vigorously transformed the organization of the public hospitals in the Belgian capital. During World War I Queen Elisabeth appointed him surgeon-in-chief of the Océan-hospital in De Panne, where more than 50,000 soldiers with wounds, fractures, cerebral trauma, nitrous gas intoxication, and infectious diseases, among other problems were treated. The results he and his team obtained were excellent, and mortality was low. Many surgeons, including Alexis Carrel, as well as distinguished political leaders came to visit him in the hospital barracks. After the war he was honored by many political and scientific organizations, including the Société Internationale de Chirurgie. He served our Society not only as Secretary General from 1902 to 1912 but became President of the 4th Congress of the ISS-SIC in New York. Antoine Depage died after a long illness in 1925. PMID:12205562

  10. Commentary on "Reproductive factors and kidney cancer risk in 2 US cohort studies, 1993-2010." Karami S, Daugherty SE, Schonfeld SJ, Park Y, Hollenbeck AR, Grubb RL 3rd, Hofmann JN, Chow WH, Purdue MP, Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD. Am J Epidemiol 2013; 177(12):1368-77. [Epub 2013 Apr 26]. doi: 10.1093/aje/kws406.

    PubMed

    Boorjian, Stephen

    2014-08-01

    Clinical and experimental findings suggest that female hormonal and reproductive factors could influence kidney cancer development. To evaluate this association, we conducted analyses in 2 large prospective cohorts (the National Institutes of Health-AARP Diet and Health Study (NIH-AARP), 1995-2006, and the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial (PLCO), 1993-2010). Cohort-specific and aggregated hazard ratios and 95% confidence intervals relating reproductive factors and kidney cancer risk were computed by Cox regression. The analysis included 792 incident kidney cancer cases among 283,952 postmenopausal women. Women who had undergone a hysterectomy were at a significantly elevated kidney cancer risk in both NIH-AARP (hazard ratio = 1.28, 95% confidence interval: 1.09, 1.50) and PLCO (hazard ratio = 1.41, 95% confidence interval: 1.06, 1.88). Similar results were observed for both cohorts after analyses were restricted to women who had undergone a hysterectomy with or without an oophorectomy. For the NIH-AARP cohort, an inverse association was observed with increasing age at menarche (P for trend= 0.02) and increasing years of oral contraceptive use (P for trend = 0.02). No clear evidence of an association with parity or other reproductive factors was found. Our results suggest that hysterectomy is associated with increased risk of kidney cancer. The observed associations with age at menarche and oral contraceptive use warrant further investigation. PMID:25087669

  11. 78 FR 24584 - Imposition of Special Measures Against Halawi Exchange Co. as a Financial Institution of Primary...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-25

    ... less than 1% of small broker-dealers. \\8\\ 17 CFR 240.0-10(c). \\9\\ 76 FR 37572, 37602 (June 27, 2011... small FCMs. \\10\\ 47 FR 18618, 18619 (Apr. 30, 1982). For purposes of the RFA, an introducing broker.... \\11\\ SBA Size Standards at 28. \\12\\ 77 FR 20128, 20197 (Apr. 3, 2012). \\13\\ 2007 Economic...

  12. 78 FR 24575 - Imposition of Special Measures Against Kassem Rmeiti & Co. for Exchange as a Financial...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-25

    ...-dealers. \\8\\ 17 CFR 240.0-10(c). \\9\\ 76 FR 37572, 37602 (June 27, 2011) (The SEC estimates 871 small... FCMs. \\10\\ 47 FR 18618, 18619 (Apr. 30, 1982). For purposes of the RFA, an introducing broker.... \\11\\ SBA Size Standards at 28. \\12\\ 77 FR 20128, 20197 (Apr. 3, 2012). \\13\\ 2007 Economic...

  13. 78 FR 79534 - Self-Regulatory Organizations; New York Stock Exchange LLC; NYSE MKT LLC; Order Approving...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ... Exchange Act Release No. 67437, 77 FR 42525 (July 13, 2012) (``Disapproval Order''). A. Trading Floor... Exchange Act Release Nos. 69427 (Apr. 23, 2013), 78 FR 25118 (SR-NYSE-2013-21) (``NYSE Notice'') and 69428 (Apr. 23, 2013), 78 FR 25102 (SR-NYSEMKT-2013-25) (``NYSE MKT Notice'') (collectively ``Notices'')....

  14. 78 FR 19356 - Notice of Schedule Information Submission Deadline for O'Hare International Airport, San...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-29

    ... International Airport, 73 FR 3510 (Jan. 18, 2008) as amended 76 FR 18620 (Apr. 4, 2011); Operating Limitations at Newark Liberty International Airport, 73 FR 29550 (May 21, 2008) as amended 76 FR 18618 (Apr. 4... International Airport, San Francisco International Airport, John F. Kennedy International Airport, and...

  15. Evaluation of phytotoxicity of acibenzolar on fresh market bell peppers, 2012

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This experiment was conducted inTifton, Georgia to evaluate the phytotoxicity of acibenzolar on fresh market bell peppers in 2012 for the control of bacterial spot. Five broadcast foliar applications were applied on a 6-8 day schedule beginning on 2 Apr and ending on 29 May 2012. On 2 and 17 Apr a...

  16. 78 FR 36017 - MCM Rail Services LLC, d/b/a Baltimore Industrial Railroad-Operation Exemption-Hilco SP Rail, LLC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-14

    ... Railroad Holding, LLC, FD 35734 (STB served Apr. 26, 2013); 78 FR 24,803 (Apr. 26, 2013). MCM's notice was... Surface Transportation Board MCM Rail Services LLC, d/b/a Baltimore Industrial Railroad-- Operation Exemption--Hilco SP Rail, LLC MCM Rail Services LLC, d/b/a Baltimore Industrial Railroad (MCM), a...

  17. 50 CFR 100.26 - Subsistence taking of wildlife.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... season. Unit 1D No open season. Coyote: 2 coyotes Sept. 1-Apr. 30. Fox, Red (including Cross, Black, and...): 20 per day, 40 in possession Aug. 1-May 15. TRAPPING Beaver: Unit 1—No limit Dec. 1-May 15. Coyote... qualified subsistence users hunting under these regulations Coyote: 2 coyotes Sept. 1-Apr. 30. Fox,...

  18. 36 CFR 242.26 - Subsistence taking of wildlife.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... season. Unit 1D No open season. Coyote: 2 coyotes Sept. 1-Apr. 30. Fox, Red (including Cross, Black, and...): 20 per day, 40 in possession Aug. 1-May 15. TRAPPING Beaver: Unit 1—No limit Dec. 1-May 15. Coyote... qualified subsistence users hunting under these regulations Coyote: 2 coyotes Sept. 1-Apr. 30. Fox,...

  19. 50 CFR 100.26 - Subsistence taking of wildlife.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... season. Unit 1D No open season. Coyote: 2 coyotes Sept. 1-Apr. 30. Fox, Red (including Cross, Black, and...): 20 per day, 40 in possession Aug. 1-May 15. TRAPPING Beaver: Unit 1—No limit Dec. 1-May 15. Coyote... qualified subsistence users hunting under these regulations Coyote: 2 coyotes Sept. 1-Apr. 30. Fox,...

  20. 36 CFR 242.26 - Subsistence taking of wildlife.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... season. Unit 1D No open season. Coyote: 2 coyotes Sept. 1-Apr. 30. Fox, Red (including Cross, Black, and...): 20 per day, 40 in possession Aug. 1-May 15. TRAPPING Beaver: Unit 1—No limit Dec. 1-May 15. Coyote... qualified subsistence users hunting under these regulations Coyote: 2 coyotes Sept. 1-Apr. 30. Fox,...

  1. 77 FR 43892 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-26

    ... Commission recently approved. See Securities Exchange Act Release No. 34-66279 (January 30, 2012), 77 FR 5611... FR 43842 (Aug. 23, 1995). \\8\\ 15 U.S.C. 6102. In 1997, the Commission determined that telemarketing... Additional Rulemaking Required, Securities Exchange Act Release No. 38480 (Apr.7, 1997), 62 FR 18666 (Apr....

  2. 76 FR 77593 - Proposed Exemptions From Certain Prohibited Transaction Restrictions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-13

    ... (55 FR 32836, 32847, August 10, 1990). Effective December 31, 1978, section 102 of Reorganization Plan... procedures set forth in 29 CFR part 2570, subpart B (55 FR 32836, 32847, August 10, 1990).\\1\\ \\1\\ For... notes that Class Exemption 80-26 (45 FR 28545 (Apr. 29, 1980), as amended at 71 FR 17917 (Apr. 7,...

  3. 75 FR 41017 - Political Contributions by Certain Investment Advisers

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-14

    ... Release No. 2910 (Aug. 3, 2009) [74 FR 39840 (Aug. 7, 2009)] (the ``Proposing Release''). \\30\\ MSRB rule G... the Proposed Rule, Exchange Act Release No. 33868 (Apr. 7, 1994) [59 FR 17621 (Apr. 13, 1994)]. The.... 8, 1987) [52 FR 38400 (Oct. 16, 1987)]. Most public pension plans establish procedures for...

  4. 75 FR 11231 - Amendments to Regulation SHO

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-10

    ...), 64 FR 57996 (Oct. 28, 1999) (``1999 Concept Release''). \\5\\ See Exchange Act Release No. 50104 (July 28, 2004), 69 FR 48032 (Aug. 6, 2004) (``Pilot Release''). \\6\\ See http://www.sec.gov/about/economic... Exchange Act Release No. 59748 (Apr. 10, 2009), 74 FR 18042, 18043 (Apr. 20, 2009) (the ``Proposal'')....

  5. 75 FR 14103 - Version One Regional Reliability Standard for Resource and Demand Balancing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-24

    ... Establishment, Approval, and Enforcement of Electric Reliability Standards, Order No. 672, 71 FR 8662 (Feb. 17, 2006), FERC Stats. & Regs. ] 31,204, at P 290 (2006); order on reh'g, Order No. 672-A, 71 FR 19814 (Apr... the Bulk-Power System, Order No. 693, 72 FR 16416 (Apr. 4, 2007), FERC Stats. & Regs. ] 31,242, at...

  6. 77 FR 16290 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-20

    ... approved. See Securities Exchange Act Release No. 66279 (Jan. 30, 2012), 77 FR 5611 (Feb. 3, 2012) (SR... Act in 1995. See Federal Trade Commission, Telemarketing Sales Rule, 60 FR 43842 (Aug. 23, 1995). \\6... Exchange Act Release No. 38480 (Apr. 7, 1997), 62 FR 18666 (Apr. 16, 1996). The Commission also...

  7. 77 FR 51076 - Self-Regulatory Organizations; National Stock Exchange, Inc.; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-23

    ... under the Prevention Act in 1995. See FTC, Telemarketing Sales Rule, 60 FR 43842 (Aug. 23, 1995). \\5\\ 15... Release No. 38480 (Apr. 7, 1997), 62 FR 18666 (Apr. 16, 1996). The Commission also determined that some..., Telemarketing Sales Rule, 73 FR 51164 (Aug. 29, 2008) (amendments to the Telemarketing Sales Rule relating...

  8. 78 FR 64173 - Swap Dealers and Major Swap Participants; Clerical or Ministerial Employees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-28

    ...'' in the context of other Commission registrants.\\5\\ \\3\\ See 77 FR 2613 (Jan. 19, 2012). \\4\\ 17 CFR 1.3... by an SD or MSP in a clerical or ministerial capacity.\\8\\ \\7\\ 78 FR 20848 (Apr. 8, 2013). \\8\\ In this... to ``individuals.'' See 48 FR 14933, 14954 n. 115 (Apr. 6, 1983). \\12\\ See 77 FR 2613, 2620 (Jan....

  9. A Call To Action III: 1989/90 Legislative Agenda.

    ERIC Educational Resources Information Center

    Association of Puerto Rican Executive Directors, New York, NY.

    This publication of the Association of Puerto Rican Executive Directors (APRED) presents recommendations for action by the New York State legislature to improve opportunities and services for the Puerto Rican and Latino community. The agenda for legislative action, produced by the APRED Legislative Task Force, calls for the integration of the…

  10. 76 FR 42150 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-18

    ... underlying orders. \\4\\ See Securities Exchange Act Release No. 56017 (July 5, 2007), 72 FR 38110 (July 12... Securities Exchange Act Release No. 56968 (Dec. 14, 2007), 72 FR 72432 (Dec. 20, 2007) (SR-NYSE-2007-114). \\7\\ See Securities Exchange Act Release Nos. 57682 (Apr. 17, 2008), 73 FR 22193 (Apr. 24, 2008)...

  11. A Longitudinal Study of Academic Progress Rate as a Result of Team and Institutional Variables at NCAA Division I Schools

    ERIC Educational Resources Information Center

    Hale, Jimmie Edwin

    2014-01-01

    This study explained Academic Progress Rate (APR) levels and differences in APR (DAPR) with team and institutional variables. Team variables included team gender, sport profile, and squad size. Institutional variables included individual variables aggregated to the institutional level. The data analyzed in this study was derived from the National…

  12. Electron transfer between the QmoABC membrane complex and adenosine 5'-phosphosulfate reductase.

    PubMed

    Duarte, Américo G; Santos, André A; Pereira, Inês A C

    2016-04-01

    The dissimilatory adenosine 5'-phosphosulfate reductase (AprAB) is a key enzyme in the sulfate reduction pathway that catalyzes the reversible two electron reduction of adenosine 5'-phosphosulfate (APS) to sulfite and adenosine monophosphate (AMP). The physiological electron donor for AprAB is proposed to be the QmoABC membrane complex, coupling the quinone-pool to sulfate reduction. However, direct electron transfer between these two proteins has never been observed. In this work we demonstrate for the first time direct electron transfer between the Desulfovibrio desulfuricans ATCC 27774 QmoABC complex and AprAB. Cyclic voltammetry conducted with the modified Qmo electrode and AprAB in the electrolyte solution presented the Qmo electrochemical signature with two additional well-defined one electron redox processes, attributed to the AprAB FAD redox behavior. Moreover, experiments performed under catalytic conditions using the QmoABC modified electrode, with AprAB and APS in solution, show a catalytic current peak develop in the cathodic wave, attributed to substrate reduction, and which is not observed in the absence of QmoABC. Substrate dependence conducted with different electrode preparations (with and without immobilized Qmo) demonstrated that the QmoABC complex is essential for efficient electron delivery to AprAB, in order to sustain catalysis. These results confirm the role of Qmo in electron transfer to AprAB. PMID:26768116

  13. 78 FR 62893 - Self-Regulatory Organizations; National Securities Clearing Corporation; Notice of Filing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-22

    ... Rule 19b-4 thereunder. Release No. 34-69313 (Apr. 4, 2013), 78 FR 21487 (Apr. 10, 2013). On April 19... Change, as modified by Amendment No. 1. Release No. 34-69620 (May 22, 2013), 78 FR 32292 (May 29, 2013... Proposed Rule Change (``Order Instituting Proceedings''). Release No. 34-69951 (Jul. 9, 2013), 78 FR...

  14. 77 FR 14303 - Federal Acquisition Regulation; Women-Owned Small Business (WOSB) Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-09

    ... PROVISIONS AND CONTRACT CLAUSES 1. On page 12918 in Sec. 52.212-3, in the first column, the fifteenth line... Items (APR 2012)'' 2. On page 12918 in Sec. 52.212-5, in the first column, the fifth line from the... Executive Orders-- Commercial Items (APR 2012)'' 3. On page 12918 in Sec. 52.219-29, in the second...

  15. 78 FR 22251 - Agency Information Collection Activities; Comment Request; IDEA Part B State Performance Plan...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-15

    ... Performance Plan (SPP) and Annual Performance Report (APR). OMB Control Number: 1820-0624. Type of Review: a... Agency Information Collection Activities; Comment Request; IDEA Part B State Performance Plan (SPP) and Annual Performance Report (APR) AGENCY: Office of Special Education and Rehabilitative Services...

  16. 78 FR 22253 - Agency Information Collection Activities; Comment Request; IDEA Part C State Performance Plan...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-15

    ... Performance Plan (SPP) and Annual Performance Report (APR). OMB Control Number: 1820-0578. Type of Review: a... Agency Information Collection Activities; Comment Request; IDEA Part C State Performance Plan (SPP) and Annual Performance Report (APR) AGENCY: Office of Special Education and Rehabilitative Services...

  17. 75 FR 482 - Self-Regulatory Organizations; Notice of Filing and Immediate Effectiveness of Proposed Rule...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-05

    ... underlying orders. \\4\\ See Securities Exchange Act Release No. 34-56017 (July 5, 2007), 72 FR 38110 (July 12... Securities Exchange Act Release No. 56968 (Dec. 14, 2007), 72 FR 72432 (Dec. 20, 2007), SR-NYSE-2007-114. \\7\\ See Securities Exchange Act Release Nos. 57682 (Apr. 17, 2008), 73 FR 22193 (Apr. 24, 2008)...

  18. Prospects for the Development and Internationalization of Higher Education in Asia

    ERIC Educational Resources Information Center

    Krechetnikov, Konstantin; Pestereva, Nina; Rajovic, Goran

    2016-01-01

    This study investigates the current process of internationalization of higher education in the countries of the Asia Pacific region (APR) through the example of China, the Republic of Korea, Japan, and Russia. The article aims to familiarize the reader with the experience of internationalizing higher education in APR states against a backdrop of…

  19. Efficacy of ProPhyt mixed with a low rate of Captec for control of peach scab in South Carolina, 2014

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Fungicides were evaluated for control of scab in a mid-ripening experimental nectarine block (‘Redgold’) located at the Clemson University Research Station in Seneca, SC. Chemical formulations were applied with a handgun sprayer (200 gal/A spray volume) on 1 Apr (petal fall), 9 Apr (shuck split) and...

  20. 50 CFR 32.8 - Areas closed to hunting.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    .... 2239 Apr. 10, 1939 Georgia Savannah National Wildlife Refuge 3 CFR Cum. Supp.; 4 FR 1595. Nov. 3, 1970... Wildlife Refuge 25 FR 7741. 2617 Oct. 18, 1948 Massachusetts Parker River National Wildlife Refuge 3 CFR... Wildlife Refuge 47 Stat. 2513. 2329 Apr. 10, 1939 .......do Savannah National Wildlife Refuge 3 CFR,...

  1. Special Education Report to the 2005 Montana Legislature

    ERIC Educational Resources Information Center

    Montana Office of Public Instruction, 2005

    2005-01-01

    The Annual Performance Report (APR) for Grant Year July 1, 2002, through June 30, 2003, was submitted to the U.S. Department of Education in accordance with the requirements of the U.S. Department of Education, Office of Special Education Programs (OSEP). The OSEP designed the APR to serve as a state?s self-assessment and improvement planning…

  2. 78 FR 32214 - Land Acquisitions: Appeals of Land Acquisition Decisions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-29

    ... in trust. See 61 FR 18082 (Apr. 24, 1996). The Department had determined such rule was necessary... of the Secretary's decision under the APA. See 61 FR 18082 (Apr. 24, 1996). The stated reason for... Governments,'' Executive Order 13175 (59 FR 22951, November 6, 2000), and 512 DM 2, we have evaluated...

  3. 75 FR 68559 - Disclosure Requirements and Prohibitions Concerning Business Opportunities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-08

    ... 1, 2009 to discuss proposed amended disclosure requirements.\\4\\ \\2\\ 71 FR 19,056 (Apr. 12, 2006). \\3\\ 73 FR 16,110 (Mar. 28, 2008). \\4\\ 74 FR 18,712 (Apr. 24, 2009). Pursuant to the Commission's Rules of... CFR Part 437 Disclosure Requirements and Prohibitions Concerning Business Opportunities...

  4. 78 FR 47467 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-05

    ... Exchange Act Release No. 59598 (Mar. 18, 2009), 74 FR 12919 (Mar. 25, 2009) (SR-NYSEArca-2009-05). In April... Act Release No. 69274 (Apr. 2, 2013), 78 FR 20986 (Apr. 8, 2013) (SR-NYSEArca-2013-30). No other... the need for such data.\\8\\ \\8\\ See Securities Exchange Act Release No. 51808 (June 9, 2005), 70...

  5. 78 FR 47474 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-05

    ... (Mar. 19, 2009), 74 FR 13293 (Mar. 26, 2009) (SR-NYSE-2009-04). In April 2013, the Exchange began.... \\5\\ See Securities Exchange Act Release No. 69272 (Apr. 2, 2013), 78 FR 20983 (Apr. 8, 2013) (SR-NYSE... the need for such data.\\8\\ \\8\\ See Securities Exchange Act Release No. 51808 (June 9, 2005), 70...

  6. Genomic selection for quantitative adult plant stem rust resistance in wheat

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Quantitative adult plant resistance (APR) to stem rust (Puccinia graminis f. sp. tritici) is an important breeding target in wheat (Triticum aestivum L.) and a potential target for genomic selection (GS). To evaluate the relative importance of known APR loci in applying genomic selection, we charact...

  7. 78 FR 31842 - Determination of Rates and Terms for Preexisting Subscription Services and Satellite Digital...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-28

    ... published the Final Determination on April 17, 2013, as required by 17 U.S.C. 803(c)(6).\\1\\ See 78 FR 23054... dissent was published with the Final Determination. See 78 FR 23075- 96 (Apr. 17. 2013). References to the... adjusted rates. See 78 FR 22913 (Apr. 17, 2013). After careful consideration, the Judges find that such...

  8. 77 FR 26348 - Self-Regulatory Organizations; EDGA Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-03

    ... Securities Exchange Act Release No. 66279 (Jan. 30, 2012), 77 FR 5611 (Feb. 3, 2012) (SR-FINRA-2011-059... Act in 1995. See Federal Trade Commission, Telemarketing Sales Rule, 60 FR 43842 (Aug. 23, 1995). \\6... Exchange Act Release No. 38480 (Apr. 7, 1997), 62 FR 18666 (Apr. 16, 1997). The Commission also...

  9. 77 FR 26343 - Self-Regulatory Organizations; EDGX Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-03

    ... Securities Exchange Act Release No. 66279 (Jan. 30, 2012), 77 FR 5611 (Feb. 3, 2012) (SR-FINRA-2011-059... Act in 1995. See Federal Trade Commission, Telemarketing Sales Rule, 60 FR 43842 (Aug. 23, 1995). \\6... Exchange Act Release No. 38480 (Apr. 7, 1997), 62 FR 18666 (Apr. 16, 1997). The Commission also...

  10. 77 FR 15577 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-16

    ... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a.../0280 2/23/12 ILS RWY 23, ILS Kingsport. Cities Rgnl. RWY 23 (CAT II), Amdt 24D. 5-Apr-12 AK Soldotna... (CAT II), ILS RWY 11 (CAT III), Orig-A. 5-Apr-12 MO St Louis........ Lambert-St Louis 2/2721...

  11. 76 FR 53015 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-24

    ... Exchange Act Release No. 63895 (February 11, 2011), 76 FR 9386 (February 17, 2011) (SR-FINRA-2009-090). The...\\ See Securities Exchange Act Release Nos. 56968 (Dec. 14, 2007), 72 FR 72432 (Dec. 20, 2007) (SR-NYSE-2007-114); 57682 (Apr. 17, 2008), 73 FR 22193 (Apr. 24, 2008) (SR-NYSE-2008-29); 59621 (Mar. 23,...

  12. Genetics Home Reference: Koolen-de Vries syndrome

    MedlinePlus

    ... Genet. 2011 Mar-Apr;54(2):144-51. doi: 10.1016/j.ejmg.2010.11.003. Epub ... Genet A. 2013 Jan;161A(1):21-6. doi: 10.1002/ajmg.a.35652. Epub 2012 Nov ... Genet. 2012 Apr 6;90(4):599-613. doi: 10.1016/j.ajhg.2012.02.013. Citation ...

  13. Genetics Home Reference: Kabuki syndrome

    MedlinePlus

    ... Hum Genet. 2012 Apr;57(4):223-7. doi: 10.1038/jhg.2012.28. Epub 2012 Mar ... Hum Genet. 2009 May;54(5):304-9. doi: 10.1038/jhg.2009.30. Epub 2009 Apr ... Genet. 2012 Jan 13;90(1):119-24. doi: 10.1016/j.ajhg.2011.11.021. Epub ...

  14. Efficacy of fungicides for control of scab on a mid-ripening peach variety in middle Georgia, 2012

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Fungicides were evaluated for control of scab in a mid-ripening experimental peach block (‘Flameprince’) located at the USDA-ARS Fruit and Tree Nut Research Laboratory (Byron, GA). Chemical formulations were applied at each application date: 3 Apr (petal fall to 1% shuck split), 10 Apr (shuck split ...

  15. 31 CFR 351.19 - What are maturity periods of Series EE savings bonds with issue dates prior to May 1, 1995?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Jan. 1980-Oct. 1980 11 10 9 Jan. 2010-Oct. 2010. Nov. 1980-Apr. 1981 9 10 11 Nov. 2010-Apr. 2011. May 1981-Oct. 1982 8 10 12 May 2011-Oct. 2012. Nov. 1982-Oct. 1986 10 10 10 Nov. 2012-Oct. 2016. Nov....

  16. 31 CFR 351.19 - What are maturity periods of Series EE savings bonds with issue dates prior to May 1, 1995?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...-Oct. 1980 11 10 9 Jan. 2010-Oct. 2010. Nov. 1980-Apr. 1981 9 10 11 Nov. 2010-Apr. 2011. May 1981-Oct. 1982 8 10 12 May 2011-Oct. 2012. Nov. 1982-Oct. 1986 10 10 10 Nov. 2012-Oct. 2016. Nov. 1986-Feb....

  17. Efficacy of petal fall and shuck split fungicides for control of scab on peach in middle Georgia, 2012

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Fungicides were evaluated for control of scab in a mid-ripening experimental peach block (‘Flameprince’) located at the USDA-ARS Fruit and Tree Nut Research Laboratory (Byron, GA). Chemical formulations were applied at each application date: 3 Apr (petal fall to 1% shuck split), 10 Apr (shuck split ...

  18. 76 FR 10628 - Self-Regulatory Organizations; the Depository Trust Company; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-25

    .... Securities Exchange Act Release No. 61922 (Apr. 15, 2010), 75 FR 21072 (Apr. 22, 2010). Also in 2010, DTC... Release No. 63415 (Dec. 2, 2010), 75 FR 76506 (Dec. 8, 2010). DTC states that the proposed rule change is... Effectiveness of Proposed Rule Change Regarding Providing Participants With a New Optional Settlement...

  19. 78 FR 38270 - Endangered and Threatened Wildlife; Proposed Rule To Revise the Code of Federal Regulations for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-26

    ......... Canary rockfish originating from Puget 75 FR 22276, Apr 28, NA NA Georgia Basin DPS). Sound and the... originating from Puget 75 FR 22276, Apr 28, NA NA Georgia Basin DPS). Sound and the Georgia Basin. 2010... salmon ESUs and steelhead DPSs in California (76 FR 50447, August 15, 2011; and 76 FR 76386, December...

  20. 77 FR 30504 - Certain Orange Juice From Brazil: Notice of Rescission of Antidumping Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-23

    ... Request Administrative Review, 77 FR 12559 (Mar. 1, 2012). On March 30, 2012, in accordance with section....\\2\\ \\2\\ See Revocation of Antidumping Duty Order: Certain Orange Juice From Brazil, 77 FR 23659 (Apr..., 77 FR 25401 (Apr. 30, 2012). On May 11, 2012, Southern Gardens timely withdrew its request...

  1. 76 FR 70921 - Implementation of the Fair Housing Act's Discriminatory Effects Standard

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-16

    ... Discrimination in Lending, 59 FR 18,266, 18,268 (Apr. 15, 1994). In addition, in regulations implementing the... (Fannie Mae) and the Federal Home Loan Mortgage Corporation (Freddie Mac), 60 FR. 61,846, 61,867 (Dec. 1...); see also Policy Statement on Discrimination in Lending, 59 FR. 18,266, 18,269 (Apr. 15,...

  2. 76 FR 25299 - Notice of Petitions by Firms for Determination of Eligibility To Apply for Trade Adjustment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-04

    ... Flat Street, 21-Apr-11 The firm manufactures Cumberland, RI 02864. architectural woodwork such as..., 26-Apr-11 The firm manufactures acoustic Inc. Braintree, MA 02184. countermeasures--electro-acoustic products used to decoy/confuse acoustic homing torpedoes, sonar transducers. Any party having a...

  3. 77 FR 32004 - Guidelines for the Supervisory Review Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-31

    ... supervisory determinations credit unions may appeal to the Committee. 78 FR 19778 (Apr. 23, 2002). In order to.... 309(a), 108 Stat. 2160 (1994); 60 FR 14795 (Mar. 20, 1995). Through IRPS 95-1, NCUA established a... Board combined IRPS 95-1 and 02-1 into IRPS 11-1. 83 FR 23871 (Apr. 29, 2011). In December 2011,...

  4. 78 FR 55126 - Order Exempting Broker-Dealers Participating in NYSE Arca, Inc.'s Lead Market Maker Incentive...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-09

    ..., 2013), 78 FR 35340 (June 12, 2013) (SR-NYSEArca-2013-34) (the ``Approval Order''). The Approval Order... on April 11, 2013. Securities Exchange Act Release No. 69335 (Apr. 5, 2013), 78 FR 21681 (Apr. 11...., Exchange Act Release Nos. 6726 (Feb. 8, 1962), 27 FR 1415 (Feb. 15, 1962) and 21577 (Dec. 18, 1984), 49...

  5. 78 FR 16311 - Self-Regulatory Organizations; Chicago Stock Exchange, Inc.; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-14

    ... executable without repricing. \\8\\ Securities Exchange Act Release No. 64319 (Apr. 21, 2011), 76 FR 23634 (Apr... entry and in certain cases again reprices and re-displays an order at a more aggressive price one time... achieves a more aggressive price, based upon changes to the prevailing NBBO; provided, however, that...

  6. Identification of QTL for adult plant resistance to stripe rust in Chinese wheat landrace Caoxuan 5

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Yellow (or stripe) rust, caused by Puccinia striiformis f. sp. tritici (Pst), is an important wheat disease worldwide. The development of wheat cultivars with adult plant resistance (APR) has been given increasing emphasis in recent years because of the reputed durability of APR compared to all-stag...

  7. 75 FR 77687 - Self-Regulatory Organizations; Notice of Filing and Immediate Effectiveness of Proposed Rule...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-13

    ... underlying orders. \\4\\ See Securities Exchange Act Release No. 56017 (July 5, 2007), 72 FR 38110 (July 12... Securities Exchange Act Release No. 56968 (Dec. 14, 2007), 72 FR 72432 (Dec. 20, 2007) (SR-NYSE-2007-114). \\7\\ See Securities Exchange Act Release Nos. 57682 (Apr. 17, 2008), 73 FR 22193 (Apr. 24, 2008)...

  8. 75 FR 77685 - Self-Regulatory Organizations; Notice of Filing and Immediate Effectiveness of Proposed Rule...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-13

    ... all of the underlying orders. \\5\\ See Securities Exchange Act Release No. 56017 (Jul. 5, 2007), 72 FR... Exchange Act Release No. 56968 (Dec. 14, 2007), 72 FR 72432 (Dec. 20, 2007) (SR-NYSE-2007-114). \\8\\ See Securities Exchange Act Release Nos. 57682 (Apr. 17, 2008), 73 FR 22193 (Apr. 24, 2008)...

  9. 9 CFR 381.224 - Designation of States under section 11 of the Act; application of sections of the Act and the...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Puerto Rico Rhode Island South Dakota Tennessee Virgin Islands Washington July 31, 1999. Apr. 1, 1976... Hampshire New Jersey New York Northern Mariana Islands Oregon Pennsylvania Puerto Rico Rhode Island South Dakota Tennessee Virgin Islands Washington July 31, 1999. Apr. 1, 1976. July 1, 1975. Oct. 1, 1975....

  10. 9 CFR 381.224 - Designation of States under section 11 of the Act; application of sections of the Act and the...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Puerto Rico Rhode Island South Dakota Tennessee Virgin Islands Washington July 31, 1999. Apr. 1, 1976... Hampshire New Jersey New York Northern Mariana Islands Oregon Pennsylvania Puerto Rico Rhode Island South Dakota Tennessee Virgin Islands Washington July 31, 1999. Apr. 1, 1976. July 1, 1975. Oct. 1, 1975....

  11. 75 FR 38557 - Application Nos. and Proposed Exemptions; D-11489, Morgan Stanley & Co., Incorporated; L-11609...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-02

    ... (55 FR 32836, 32847, August 10, 1990). Effective December 31, 1978, section 102 of Reorganization Plan... (the Code), and in accordance with the procedures set forth in 29 CFR part 2570, subpart B (55 FR 32836... Prohibited Transaction Exemption (PTE) 80-26 (45 FR 28545 (Apr. 29, 1980), as amended at 71 FR 17917 (Apr....

  12. 77 FR 19410 - Notice of Schedule Information Submission Deadline for O'Hare International Airport, San...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-30

    ... Airport, 73 FR 3510 (Jan. 18, 2008) as amended 76 FR 18620 (Apr. 4, 2011); Operating Limitations at Newark Liberty International Airport, 73 FR 29550 (May 21, 2008) as amended 76 FR 18618 (Apr. 4, 2011). The FAA... Liberty International Airport for the Winter 2012-2013 Scheduling Season AGENCY: Department...

  13. 76 FR 56868 - Notice of Submission Deadline for Schedule Information for O'Hare International Airport, John F...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-14

    ... Airport, 73 FR 3510 (Jan. 18, 2008) as amended 76 FR 18620 (Apr. 4, 2011); Operating Limitations at Newark Liberty International Airport, 73 FR 29550 (May 21, 2008) as amended 76 FR 18618 (Apr. 4, 2011). The FAA... International Airport, John F. Kennedy International Airport, and Newark Liberty International Airport for...

  14. 77 FR 58608 - Notice of Submission Deadline for Schedule Information for O'Hare International Airport, San...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-21

    ... Limitations at John F. Kennedy International Airport, 73 FR 3510 (Jan. 18, 2008) as amended 76 FR 18620 (Apr. 4, 2011); Operating Limitations at Newark Liberty International Airport, 73 FR 29550 (May 21, 2008) as amended 76 FR 18618 (Apr. 4, 2011). The FAA is primarily concerned about planned passenger...

  15. Increases in the serum acute phase proteins after ozone exposure are associated with induction of genes in the lung but not liver

    EPA Science Inventory

    Acute Phase Response (APR), a systemic reaction to infection, trauma, and inflammation, is characterized by increases and decreases in plasma levels of positive and negative acute phase proteins (APP), respectively. Although the liver has been shown to contribute to APR in variou...

  16. 78 FR 54718 - Self-Regulatory Organizations; ICE Clear Europe Limited; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-05

    ...); see Securities Exchange Act Release No. 69628 (Apr. 9, 2013), 78 FR 22350, 22351-52 (Apr. 15, 2013... COMMISSION Self-Regulatory Organizations; ICE Clear Europe Limited; Notice of Filing and Immediate... is hereby given that on August 20, 2013, ICE Clear Europe Limited (``ICE Clear Europe'') filed...

  17. 77 FR 66219 - Clearing Agency Standards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-02

    ... to clear credit default swaps. See Exchange Act Release Nos. 60372 (July 23, 2009), 74 FR 37748 (July 29, 2009), 61973 (Apr. 23, 2010), 75 FR 22656 (Apr. 29, 2010) and 63389 (Nov. 29, 2010), 75 FR 75520 (Dec. 3, 2010) (CDS clearing by ICE Clear Europe Limited); 60373 (July 23, 2009), 74 FR 37740 (July...

  18. 78 FR 29186 - Self-Regulatory Organizations; The Depository Trust Company; Order Approving Proposed Rule Change...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-17

    ...\\ Release No. 34-69276 (Apr. 2, 2013), 78 FR 20999 (Apr. 8, 2013). II. Description DTC filed the Proposed...)(3)(F). \\12\\ Release No. 34-68080 (Oct. 22, 2012), 77 FR 66219 (Nov. 2, 2012). \\13\\ 17 CFR 240.17Ad... May 13, 2013. I. Introduction On March 20, 2013, The Depository Trust Company (``DTC'') filed with...

  19. Annual Percentage Rate and Annual Effective Rate: Resolving Confusion in Intermediate Accounting Textbooks

    ERIC Educational Resources Information Center

    Vicknair, David; Wright, Jeffrey

    2015-01-01

    Evidence of confusion in intermediate accounting textbooks regarding the annual percentage rate (APR) and annual effective rate (AER) is presented. The APR and AER are briefly discussed in the context of a note payable and correct formulas for computing each is provided. Representative examples of the types of confusion that we found is presented…

  20. 76 FR 60593 - Title VI; Proposed Circular

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-29

    ... April 11, 2000 (65 FR 19477). Docket: For access to the docket to read background documents and comments... Low-Income Populations,'' 62 FR 18377, Apr. 15, 1977) describes the process the Department and its... that best match their resources needs, and standard practices.'' (72 FR 18732, 18735, Apr. 13,...

  1. 76 FR 29808 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Granting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-23

    .... 64341 (Apr. 26, 2011), 76 FR 24076 (Apr. 29, 2011) (SR-FINRA-2011-017). \\4\\ The Commission received one... (September 29, 2010), 75 FR 61541 (October 5, 2010) (Order Approving File No. SR- NASD-2003-140). \\6\\ See... COMMISSION Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order...

  2. BOREAS Level-0 TIMS Imagery: Digital Counts in BIL Format

    NASA Technical Reports Server (NTRS)

    Newcomer, Jeffrey A.; Dominquez, Roseanne; Hall, Forrest G. (Editor)

    2000-01-01

    For BOREAS, the TIMS imagery, along with the other remotely sensed images, was collected to provide spatially extensive information over the primary study areas. The level-0 TIMS images cover the time periods of 16-Apr-1994 to 20-Apr-1994 and 06-Sep-1994 to 17-Sep-1994. The images are available in their original uncalibrated format.

  3. 76 FR 65210 - Certain Products and Pharmaceutical Compositions Containing Recombinant Human Erythropoetin...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-20

    ... Oaks, California. 71 FR 27,742 (May 12, 2006). The complaint alleged a violation of section 337 of the... Patent (Dec. 22, 2009). The Commission granted that motion. 75 FR 18,548 (Apr. 12, 2010). Also on... stipulated district court judgment on this investigation. 75 FR 18,548 (Apr. 12, 2010). On March 11,...

  4. The expression and genetics of resistance to stripe (yellow) rust in three European and four New Zealand wheat cultivars.

    PubMed

    Pathan, Amin K; Park, Robert F; Wellings, Colin R; Bariana, Harbans S

    2007-01-01

    Adult plant resistance (APR) to stripe rust in three European (Pegaso, Victo and Aztec) and four New Zealand cultivars (Weka, Kopara, Kokart and Takahe) was characterised using hybrid analysis and tests of allelism. In agreement with earlier work, the APR in most of these cultivars appeared to be controlled by two or more genes with additive effects. It was suggested that heavy selection pressure should be avoided in early generations in breeding programs utilising APR, because lines in which APR genes are heterozygous may display lower levels of resistance due to the incompletely dominant and interactive nature of many APRs. Such lines are capable of generating more resistant progenies following selfing. It was also demonstrated that it is possible to misclassify F2 plants as susceptible if APR genes are in a heterozygous condition, especially in the case of gene(s) conferring intermediate levels of resistance. The presence of a common APR gene in Kopara and Takahe, and perhaps Weka, was suggested because all shared a common parent in their pedigree and no susceptible plants were observed in F2 populations derived from intercrossing them. The difficulties inherent in conducting genetic studies on APRs and the need for large population sizes for such studies were emphasised. PMID:17666772

  5. 75 FR 76677 - Financial Crimes Enforcement Network: Anti-Money Laundering Program and Suspicious Activity...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-09

    ... vulnerabilities. \\7\\ 31 U.S.C. 5312(a)(2)(P). \\8\\ See 31 CFR 103.170; 67 FR 21113 (Apr. 29, 2002), as amended at 67 FR 67549 (Nov. 6, 2002) and corrected at 67 FR 68935 (Nov. 14, 2002). The statutory mandate that... defined. \\11\\ See 68 FR 17569 (Apr. 10, 2003). This category of financial institution is listed at 31...

  6. Expression and characterization of Coprothermobacter proteolyticus alkaline serine protease

    Technology Transfer Automated Retrieval System (TEKTRAN)

    TECHNICAL ABSTRACT A putative protease gene (aprE) from the thermophilic bacterium Coprothermobacter proteolyticus was cloned and expressed in Bacillus subtilis. The enzyme was determined to be a serine protease based on inhibition by PMSF. Biochemical characterization demonstrated the enzyme had...

  7. 78 FR 77755 - Self-Regulatory Organizations; The Depository Trust Company; Notice of Filing of Proposed Rule...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-24

    ... Procedures. \\3\\ See Securities Exchange Act Release No. 20221 (Sept. 23, 1983), 48 FR 45167 (Oct. 3, 1983... Exchange Act Release No. 19678 (Apr. 15, 1983), 48 FR 17603, 17605, n.5 (Apr. 25, 1983) (describing... Deposit Chills and Global Locks DTC maintains a robust system for monitoring its compliance with...

  8. Evaluation of phytotoxicity of acibenzolar on fresh market bell peppers, 2011

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This experiment was conducted inTifton, Georgia to evaluate the phytotoxicity of acibenzolar on fresh market bell peppers in 2011 for the control of bacterial spot. Five broadcast foliar applications were applied on a 6-8 day schedule beginning on 18 Apr and ending on 13 Jun 2011. On 18 Apr and 2 ...

  9. 78 FR 18393 - Self-Regulatory Organizations; the NASDAQ Stock Market LLC; Order Granting Approval of a Proposed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-26

    ... Release Nos. 66765 (Apr. 6, 2012), 77 FR 22042 (Apr. 12, 2012) (SR-NASDAQ-2012-043) and 68378 (Dec. 6, 2012), 77 FR 74042 (Dec. 12, 2012). See also Notice, infra note 4, at 77141, n.3. \\4\\ Securities Exchange Act Release No. 68515 (Dec. 21, 2012), 77 FR 77141 (Dec. 31, 2012) (``Notice''). \\5\\ See...

  10. [Regulation of the activity and synthesis of enzymes participating in the formation of 6,7-dimethyl-8-ribityllumazine, a riboflavin precursor in yeast].

    PubMed

    Logvinenko, E M; Shavlovskiĭ, G M; Zakal'skiĭ, A E; Samarskiĭ, V A

    1989-01-01

    The properties of two flavinogenesis enzymes--synthase of the aliphatic precursor of riboflavin (APR-synthase) and 6.7-dimethyl-8-ribityllumazinesynthase (DMRL-synthase) of Pichia guilliermondii. It is established that DMRL-synthase, uses APR as a substrate which contains, evidently, a phosphate group. The value of Km for APR is equal to 0.7.10(-5) M, for 2.4-dihydroxy-5-amino-6-ribitylaminopyrimidine--1.25.10(-5) M. It is riboflavin but not FAD that inhibits the activity of DMRL-synthase; the value (I)0.5 is equal to 2.10(-5) M. DMRL, riboflavin, flavin mononucleotide and FAD do not affect the APR-synthase activity. In iron-deficient cells of P. guilliermondii, Torulopsis candida, Debaryomyces klöckeri and Schwanniomyces occidentalis realizing the oversynthesis of riboflavin there occurs derepression of DMRL-synthase and APR-synthase. PMID:2741238

  11. The past, present and future of breeding rust resistant wheat

    PubMed Central

    Ellis, Jeffrey G.; Lagudah, Evans S.; Spielmeyer, Wolfgang; Dodds, Peter N.

    2014-01-01

    Two classes of genes are used for breeding rust resistant wheat. The first class, called R (for resistance) genes, are pathogen race specific in their action, effective at all plant growth stages and probably mostly encode immune receptors of the nucleotide binding leucine rich repeat (NB-LRR) class. The second class is called adult plant resistance genes (APR) because resistance is usually functional only in adult plants, and, in contrast to most R genes, the levels of resistance conferred by single APR genes are only partial and allow considerable disease development. Some but not all APR genes provide resistance to all isolates of a rust pathogen species and a subclass of these provides resistance to several fungal pathogen species. Initial indications are that APR genes encode a more heterogeneous range of proteins than R proteins. Two APR genes, Lr34 and Yr36, have been cloned from wheat and their products are an ABC transporter and a protein kinase, respectively. Lr34 and Sr2 have provided long lasting and widely used (durable) partial resistance and are mainly used in conjunction with other R and APR genes to obtain adequate rust resistance. We caution that some APR genes indeed include race specific, weak R genes which may be of the NB-LRR class. A research priority to better inform rust resistance breeding is to characterize further APR genes in wheat and to understand how they function and how they interact when multiple APR and R genes are stacked in a single genotype by conventional and GM breeding. An important message is do not be complacent about the general durability of all APR genes. PMID:25505474

  12. Good clinical outcomes from a 7-year holistic programme of fistula repair in Guinea

    PubMed Central

    Delamou, Alexandre; Diallo, Moustapha; Beavogui, Abdoul Habib; Delvaux, Thérèse; Millimono, Sita; Kourouma, Mamady; Beattie, Karen; Barone, Mark; Barry, Thierno Hamidou; Khogali, Mohamed; Edginton, Mary; Hinderaker, Sven Gudmund; Ruminjo, Joseph; Zhang, Wei-Hong; De Brouwere, Vincent

    2015-01-01

    ée. L'objectif de cet article est de présenter et de discuter les résultats cliniques de sept années de travail impliquant 2116 femmes traitées dans trois hôpitaux à travers le pays. Méthodes Il s'agit d'une étude de cohorte rétrospective utilisant des données extraites des dossiers médicaux de réparations de fistules menées de 2007 à 2013. Les données de l’étude ont été analysées au cours de la période allant d'avril à août 2014. Résultats La majorité des 2116 femmes qui ont subi une réparation chirurgicale avaient une fistule vésico vaginale (n = 2 045, 97%) et 3% avaient une fistule recto vaginale ou une combinaison des deux. Au total, 1748 (83%) femmes ont eu leur fistule refermée et sont devenues continentes d'urine immédiatement après la chirurgie. À la sortie, 1795 femmes (85%) avaient une fistule fermée et 1680 (79%) étaient sèches, c'est à dire qu'elles n'avaient plus de fuite d'urine et/ou de matières fécales. 115 (5%) femmes avaient toujours une incontinence résiduelle malgré la fermeture de la fistule. Le suivi à trois mois a été complété par 1663 (79%) femmes dont 1405 (84,5%) ont eu leur fistule fermée et 80% étaient continentes. 21% ont été perdues au suivi. Conclusion La réparation programmatique de routine de la fistule obstétricale dans les régions à faibles ressources peut donner de bons résultats. Toutefois, davantage d'efforts sont nécessaires pour remédier à la perte au suivi, maintenir les résultats et prévenir l'apparition et/ou la réapparition de fistules. Objetivos La fístula genital femenina continúa siendo una preocupación de salud pública en países en vías de desarrollo. Entre Enero 2007 y Septiembre 2013, el proyecto Fistula Care, manejado por EngenderHealth junto con el Ministerio de Salud de Guinea, y financiado por USAID, integró los servicios de reparación de fistula en las maternidades de hospitales generales en Guinea. El objetivo de este artículo es presentar y

  13. Identification and Partial Characterization of Extracellular Aspartic Protease Genes from Metschnikowia pulcherrima IWBT Y1123 and Candida apicola IWBT Y1384

    PubMed Central

    Reid, Vernita J.; Theron, Louwrens W.; du Toit, Maret

    2012-01-01

    The extracellular acid proteases of non-Saccharomyces wine yeasts may fulfill a number of roles in winemaking, which include increasing the available nitrogen sources for the growth of fermentative microbes, affecting the aroma profile of the wine, and potentially reducing protein haze formation. These proteases, however, remain poorly characterized, especially at genetic level. In this study, two extracellular aspartic protease-encoding genes were identified and sequenced, from two yeast species of enological origin: one gene from Metschnikowia pulcherrima IWBT Y1123, named MpAPr1, and the other gene from Candida apicola IWBT Y1384, named CaAPr1. In silico analysis of these two genes revealed a number of features peculiar to aspartic protease genes, and both the MpAPr1 and CaAPr1 putative proteins showed homology to proteases of yeast genera. Heterologous expression of MpAPr1 in Saccharomyces cerevisiae YHUM272 confirmed that it encodes an aspartic protease. MpAPr1 production, which was shown to be constitutive, and secretion were confirmed in the presence of bovine serum albumin (BSA), casein, and grape juice proteins. The MpAPr1 gene was found to be present in 12 other M. pulcherrima strains; however, plate assays revealed that the intensity of protease activity was strain dependent and unrelated to the gene sequence. PMID:22820332

  14. Effect of variable conditions on steam reforming and aqueous phase reforming of n-butanol over Ni/CeO2 and Ni/Al2O3 catalysts

    NASA Astrophysics Data System (ADS)

    Roy, B.; Sullivan, H.; Leclerc, C. A.

    2014-12-01

    A comparison of aqueous phase reforming (APR) and steam reforming (SR) of n-butanol (n-BuOH) over Ni(20 wt%) loaded Al2O3 and CeO2 catalysts has been discussed in this paper. The BuOH conversion increases as the system pressure decreases in APR and SR. For both catalysts, the H2 and CO2 selectivity increased as the pressure increased in SR, reached a maximum at the bubble point pressure, and then decreased in the APR region. The Ni/CeO2 catalyst demonstrated higher selectivity for H2 and CO2than the Ni/Al2O3 catalyst during SR, which are consistent with the results of our previous publication on APR of n-butanol (n-BuOH) over similar catalysts. Unlike in APR, the Ni/CeO2 catalyst produced CO in SR. For both of the catalysts, the activation energies for H2 and CO2 production and BuOH conversion were lower in SR than that in APR. The proposed primary reaction pathway for reforming of BuOH on both catalysts is the same for APR and SR. The n-BuOH dehydrogenated to butaldehyde followed by decarbonylation to propane. Then the propane is steam reformed to hydrogen and carbon monoxide. The CO converts to CO2 mostly through water gas shift.

  15. Trace determination of 1-aminopropanone, a potential marker for wastewater contamination by liquid chromatography and atmospheric pressure chemical ionization-mass spectrometry.

    PubMed

    Singh, Simrat P; Gardinali, Piero R

    2006-02-01

    1-Aminopropanone (APR) is a volatile aminoketone of human origin that has been identified in raw sewage and surface waters. However, the traditional methodology for the determination of APR is extremely complicated and requires a skilled chemist to achieve consistent results. This investigation presents a novel and simple method for the analysis of APR by direct derivatization in aqueous media. APR is synthesized as its hydrochloride and derivatized using mercaptoethanol and o-phthalaldehyde. The product of reaction is separated on a 15 cm x 4.6 mm Luna C-18 column (1 mL/min, 45:55 acetonitrile: Water) and detected using a single quadrupole mass spectrometer detector operated in atmospheric pressure chemical ionization (APCI) mode. Method detection limits as low as 100 nM were routinely obtained with a precision of 1.7%. Recoveries of APR were always found to be greater then 88% in surface and wastewater samples fortified at three different levels. However, despite the robustness of the method and the fact that APR was consistently detected in urine it was not present in a variety surface or wastewaters analyzed during the course of the study. These results pose a critical question on the use of APR as a tracer for human derived wastewaters. PMID:16443254

  16. Characterization of a C3 Deoxygenation Pathway Reveals a Key Branch Point in Aminoglycoside Biosynthesis.

    PubMed

    Lv, Meinan; Ji, Xinjian; Zhao, Junfeng; Li, Yongzhen; Zhang, Chen; Su, Li; Ding, Wei; Deng, Zixin; Yu, Yi; Zhang, Qi

    2016-05-25

    Apramycin is a clinically interesting aminoglycoside antibiotic (AGA) containing a highly unique bicyclic octose moiety, and this octose is deoxygenated at the C3 position. Although the biosynthetic pathways for most 2-deoxystreptamine-containing AGAs have been well characterized, the pathway for apramycin biosynthesis, including the C3 deoxygenation process, has long remained unknown. Here we report detailed investigation of apramycin biosynthesis by a series of genetic, biochemical and bioinformatical studies. We show that AprD4 is a novel radical S-adenosyl-l-methionine (SAM) enzyme, which uses a noncanonical CX3CX3C motif for binding of a [4Fe-4S] cluster and catalyzes the dehydration of paromamine, a pseudodisaccharide intermediate in apramycin biosynthesis. We also show that AprD3 is an NADPH-dependent reductase that catalyzes the reduction of the dehydrated product from AprD4-catalyzed reaction to generate lividamine, a C3' deoxygenated product of paromamine. AprD4 and AprD3 do not form a tight catalytic complex, as shown by protein complex immunoprecipitation and other assays. The AprD4/AprD3 enzyme system acts on different pseudodisaccharide substrates but does not catalyze the deoxygenation of oxyapramycin, an apramycin analogue containing a C3 hydroxyl group on the octose moiety, suggesting that oxyapramycin and apramycin are partitioned into two parallel pathways at an early biosynthetic stage. Functional dissection of the C6 dehydrogenase AprQ shows the crosstalk between different AGA biosynthetic gene clusters from the apramycin producer Streptomyces tenebrarius, and reveals the remarkable catalytic versatility of AprQ. Our study highlights the intriguing chemistry in apramycin biosynthesis and nature's ingenuity in combinatorial biosynthesis of natural products. PMID:27120352

  17. Fever and acute phase reactants in the rat.

    PubMed Central

    van Vugt, H.; van Gool, J.; Deutz, N. E.

    1988-01-01

    In rats synthesis of some acute phase reactants can be induced by a combination of corticosteroids and adrenaline. During fever both hormones show high plasma levels. We studied the effect of fever induced by intra-cerebroventricular (i.c.v.) injection of PGE2 on the acute phase response. Fever was continuously recorded and 24 h after induction acute phase reactant (APR) response was measured as indicated by the rise of alpha-macrofetoprotein (alpha M FP, alpha 2 macroglobulin of the rat). Controls received 0.9% saline i.c.v. Controls did not develop fever (dTmax less than or equal to 1 degree C) nor did they show significant APR response. The maximal rise in body temperature after PGE2 (2.6 +/- 0.7 degrees C) correlated significantly with the rise in alpha M FP concentration 24 h later. Adrenalectomy prevented the APR response completely but the magnitude of the fever reaction remained the same (2.1 +/- 0.3 degrees C). alpha-Blockade gave a smaller fever response but had no effect on the APR response. In alpha- and beta-blockade, fever response was normal but no APR response was obtained. Destroying the sympathetic nerve supply to the liver with 6-OH dopamine retarded the fever response but again APR response was not impeded. In order to differentiate between the role of fever as such and the effect of PGE2 on APR synthesis, we used heat exposure to induce hyperthermia in normal rats who showed an APR response comparable with that after i.c.v. PGE2. Pretreatment with sodium salicylate before inducing hyperthermia led to a variable rise in alpha M FP. Fever as such, without tissue injury, induces an APR response. The pathway to this effect probably involves circulating corticosterone and adrenaline, possibly via a beta-receptor mediated stimulation. PMID:2460123

  18. Salt stress represses production of extracellular proteases in Bacillus pumilus.

    PubMed

    Liu, R F; Huang, C L; Feng, H

    2015-01-01

    Bacillus pumilus is able to secrete subtilisin-like prote-ases, one of which has been purified and characterized biochemically, demonstrating great potential for use in industrial applications. In the current study, the biosynthesis and transcription of extracellular pro-teases in B. pumilus (BA06) under salt stress were investigated using various methods, including a proteolytic assay, zymogram analysis, and real-time PCR. Our results showed that total extracellular proteolytic activity, both in fermentation broth and on milk-containing agar plates, was considerably repressed by salt in a dosage-dependent manner. As Bacillus species usually secret multiple extracellular proteases, a vari-ety of individual extracellular protease encoding genes were selected for real-time PCR analysis. It was shown that proteases encoded by the aprE and aprX genes were the major proteases in the fermentation broth in terms of their transcripts in B. pumilus. Further, transcription of aprE, aprX, and epr genes was indeed repressed by salt stress. In con-trast, transcription of other genes (e.g., vpr and wprA) was not repressed or significantly affected by the salt. Conclusively, salt stress represses total extracellular proteolytic activity in B. pumilus, which can largely be ascribed to suppression of the major protease-encoding genes (aprE, aprX) at the transcriptional level. In contrast, transcription of other pro-tease-encoding genes (e.g., vpr, wprA) was not repressed by salt stress. PMID:25966269

  19. Cloning and over-expression of an alkaline protease from Bacillus licheniformis.

    PubMed

    Tang, Xue-Ming; Shen, Wei; Lakay, F M; Shao, Wei-Lan; Wang, Zheng-Xiang; Prior, B A; Zhuge, Jian

    2004-06-01

    The alkaline protease gene, apr, from Bacillus licheniformis 2709 was cloned into a Bacillus shuttle expression vector, pHL, to yield the recombinant plasmid pHL-apr. The pHL-apr was expressed in Bacillus subtilis WB600, yielding a high expression strain BW-016. The amount of alkaline protease produced in the recombinant increased by 65% relative to the original strain. SDS-PAGE analysis indicated a Mr of 30.5 kDa. The amino acid sequence deduced from the DNA sequence analysis revealed a 98% identity to that of Bacillus licheniformis 6816. PMID:15269522

  20. Observations of solar flare photon energy spectra from 20 keV to 7 MeV

    NASA Technical Reports Server (NTRS)

    Yoshimori, M.; Watanabe, H.; Nitta, N.

    1985-01-01

    Solar flare photon energy spectra in the 20 keV to 7 MeV range are derived from the Apr. 1, Apr. 4, apr. 27 and May 13, 1981 flares. The flares were observed with a hard X-ray and a gamma-ray spectrometers on board the Hinotori satellite. The results show that the spectral shape varies from flare to flare and the spectra harden in energies above about 400 keV. Effects of nuclear line emission on the continuum and of higher energy electron bremsstrahlung are considered to explain the spectral hardening.