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  1. PRESS RELEASE / PRESS RELEASE / PRESS RELEASE / PRESS RELEASE / PRESS RELEASE Ecole Centrale Paris

    E-print Network

    Paragios, Nikos

    PRESS RELEASE / PRESS RELEASE / PRESS RELEASE / PRESS RELEASE / PRESS RELEASE Ecole Centrale Paris 10 www.ecp.fr - https://twitter.com/centraleparis Opening of Mahindra Ecole Centrale (Paris, July, 23 Centrale Paris with Mahindra Educational Institutes (Mahindra Group) in partnership with Jawaharlal Nehru

  2. PRESS RELEASE / PRESS RELEASE / PRESS RELEASE / PRESS RELEASE The Ecole Centrale Paris at Paris-Saclay

    E-print Network

    Paragios, Nikos

    PRESS RELEASE / PRESS RELEASE / PRESS RELEASE / PRESS RELEASE The Ecole Centrale Paris at Paris of the combined architectural and urban development competition for the installation of the Ecole Centrale Paris on the Paris-Saclay campus, The Ecole Centrale Paris et Paris-Saclay Public Authority invite you to come

  3. PRESS RELEASE / PRESS RELEASE / PRESS RELEASE / PRESS RELEASE Ecole Centrale Paris

    E-print Network

    Paragios, Nikos

    PRESS RELEASE / PRESS RELEASE / PRESS RELEASE / PRESS RELEASE Ecole Centrale Paris Grande Voie des of Ecole Centrale Paris. The Agreement, which is the result of a strategic partnership between Centrale Paris and the Kingdom of Morocco, defines the procedures whereby the Ecole Centrale Paris and the State

  4. PRESS RELEASE FOR IMMEDIATE RELEASE

    E-print Network

    Hochberg, Michael

    -in laser. It uses the phone's on-board GPS sensor for location tracking. The DDRS uses 3D modelingPRESS RELEASE FOR IMMEDIATE RELEASE Contact: Alexander Mamishev Phone: (206) 221-5729 Fax: (206) 543-3842 UW Dietary Recorder Offers Phone-Based Laser-Assisted Weight Loss November 25, 2011 ­ Seattle

  5. FOR IMMEDIATE RELEASE PRESS RELEASE

    E-print Network

    Chin, Wei Ngan

    for a being a pioneer in championing the cause of gender equality and women's rights in Singapore. She FOR IMMEDIATE RELEASE PRESS RELEASE NAVIGATING THE LABYRINTH: GENDER DIVERSITY AND WOMEN the complex challenges for women in leadership SINGAPORE ­ Women in Singapore and around the world continue

  6. FOR IMMEDIATE RELEASE PRESS RELEASE

    E-print Network

    Chin, Wei Ngan

    , public finance, research methods, policy analysis and program evaluation, and institutional analysisFOR IMMEDIATE RELEASE PRESS RELEASE SINGAPORE'S LEE KUAN YEW SCHOOL OF PUBLIC POLICY TO HOLD will be preceded by a lecture on US- China-Philippine relations by public policy expert Eduardo Araral MANILA

  7. PRESS RELEASE FROM NEUROPSYCHOPHARMACOLOGY

    E-print Network

    Cai, Long

    in question (if not). HYPE: We take great care not to hype the papers mentioned on our press releases.114 Rates of a minor brain malformation vary in the children of mothers with depression depending of depression and took SSRIs during pregnancy and compared these to 66 children whose mothers had no history

  8. Public Relations Press Release

    E-print Network

    Ould Ahmedou, Mohameden

    of the physical size that the red deer was most closely related to the giant deer; but we can clearly reject of red deer, other giant deer and reindeer, which were living at the beginning and the end of the lastPublic Relations Department Page 1/3 Press Release Giant deers were still present in Southern

  9. EcoleCentraleParis PRESS RELEASE / PRESS RELEASE / PRESS RELEASE / PRESS RELEASE The Ecole Centrale Paris confirms its intention to be a

    E-print Network

    Paragios, Nikos

    EcoleCentraleParis PRESS RELEASE / PRESS RELEASE / PRESS RELEASE / PRESS RELEASE The Ecole Centrale Paris confirms its intention to be a digital school by creating the Digital Institute (Paris, July 8th, 2013) ­The Ecole Centrale Paris, Engineering School, announces the creation of the Digital Institute

  10. University Art Museum PRESS RELEASE

    E-print Network

    Alexandrova, Ivana

    University Art Museum PRESS RELEASE 1400 Washington Avenue, Albany, NY 12222 PH: 518-442-4038 FX: 518-442-5075 www.albany.edu/museum For Immediate Release April 9, 2015 Master of Fine Arts Thesis Exhibition Opens at University Art Museum On view May 1 through 17, 2015 Opening Reception: Friday, May 8, 5

  11. CSR Press Release Submitted by

    E-print Network

    players in the food service industry want to serve products produced without rBGH, including yogurt. We the food service industry with a policy to purchase only milk from cows not treated with artificial bovineCSR Press Release Submitted by: Categories: Posted: Another Victory for the Sustainable Food 'Moo

  12. University Art Museum PRESS RELEASE

    E-print Network

    Alexandrova, Ivana

    University Art Museum PRESS RELEASE 1400 Washington Avenue, Albany, NY 12222 PH: 518-442-4038 FX--- The University Art Museum is pleased to announce that the exhibition The Ties That Bind: Artists and Archives. Working in various mediums including video, photography, drawing, and installation, these artists comb

  13. PRESS RELEASE 6 April 2010

    E-print Network

    PRESS RELEASE 6 April 2010 Green office design and fit out company Morgan Lovell has become to reduce its impact on the environment. These include lighting based on movement sensors, w hich refurbishment of its type in the UK, w inning both a Green Apple and BIFM Aw ard ­ and the company has made

  14. Joint Press Release TWELFTH ITER NEGOTIATION MEETING

    E-print Network

    Joint Press Release TWELFTH ITER NEGOTIATION MEETING Jeju, Korea, 6 December th 2005 Delegations on an Agreement on the joint implementation of the ITER international fusion energy project. This was the first/6/05 1:21 PMDraft Joint News Release Page 1 of 2http://www.iter.org/N_12_Joint_Press_Release.htm #12

  15. Member News Nano News Press Releases

    E-print Network

    Espinosa, Horacio D.

    NanoNEWS Member News Nano News Press Releases Nano Global News Nano Reports Nano Conferences", Exploring Matter with Synchrotron Light" and "Exploring Matter with Neutrons" by ordering from here. Nano. Send your Press R Judith.LightFeather@TNTG.org 14 Oct 2006 Researchers develop bistable nano switch

  16. PRESS RELEASE For Release: June 28, 2012

    E-print Network

    Hammack, Richard

    , CPHC, NA & EU, Roanoke, VA Contact: Adam J. Cohen, LEED AP, CPHC, NA & EU, 540-774-4800, acohen, Senior Commercial Advisor, from the Royal Danish Embassy spoke about their energy self-sufficient island. Samsø Island in Denmark has become one of the first industrialized places in the world to qualify

  17. Press Release for Semantics Content Enrichment

    E-print Network

    Napp, Nils

    Press Release AAAS/ for Semantics Content Enrichment The American Association for the Advancement, and TEMIS, leading Enterprise, to offer a new, integrated, semantically fueled digital publishing A global of the digital assets under the AAAS umbrella. "We wanted a flexible and portable semantics solution that could

  18. CECAD, University of Cologne Press release

    E-print Network

    Hartmann, Robert

    by Dr. Müller, who is a specialist in internal medicine and nephrology in the Department of Internal's international aging research and the Cluster's commitment to translational medicine ­ with cutting-edge researchCECAD, University of Cologne Press release New research group at the University of Cologne

  19. Press Release: Smithsonian Book News

    E-print Network

    Miller, Scott

    anthropological subjects such as forensic anthropology, human evolution, and archaeology. Each essay builds.Ruth@nmnh.si.edu FOR IMMEDIATE RELEASE ANTHROPOLOGY EXPLORED: NEW EDITION FEATURES MORE ESSAYS, INSTRUCTOR'S GUIDE Washington, D.C. ­ August 16, 2004 ­ Smithsonian Books announces the publication of the second edition of Anthropology

  20. AccuNet/AP (Associated Press) Multimedia Archive

    ERIC Educational Resources Information Center

    Young, Terrence E., Jr.

    2004-01-01

    The AccuNet/AP Multimedia Archive is an electronic library containing the AP's current photos and a selection of pictures from their enormous print and negative library, as well as text and graphic material. It is composed of two photo databases as well as graphics, text, and audio databases. The features of this database are briefly described in…

  1. PRESS RELEASE Ecole Centrale Paris, Altran, Mazars and Socit Gnrale

    E-print Network

    Paragios, Nikos

    members: Altran is a world leader in innovation and advanced engineering and supports companiesPRESS RELEASE Ecole Centrale Paris, Altran, Mazars and Société Générale create the Open Innovation the creation of the Open Innovation Institute (IOI). The Open Innovation Institute will be responsible

  2. ApJ, in press: 25 September 2002 Our Sun. V. A Bright Young Sun Consistent with Helioseismology and Warm

    E-print Network

    Boothroyd, Arnold

    be resolved for both Earth and Mars by a young Sun that is brighter than predicted by the standard solar model. The relatively modest mass loss rates in these models are consistent with observational limits from young starsApJ, in press: 25 September 2002 Our Sun. V. A Bright Young Sun Consistent with Helioseismology

  3. ApJ, in press; this version: March 01, 2011 Secular resonance sweeping of the main asteroid belt during

    E-print Network

    Malhotra, Renu

    ApJ, in press; this version: March 01, 2011 Secular resonance sweeping of the main asteroid belt a remnant asteroid belt to survive, we de- rive a lower limit on Saturn's migration speed of 0.15 AU My-1 during the era that the 6 resonance swept through the inner asteroid belt (semimajor axis range 2

  4. Vesicles derived via AP-3 dependent recycling contribute to asynchronous release and influence information transfer

    PubMed Central

    Evstratova, Alesya; Chamberland, Simon; Faundez, Victor; Tóth, Katalin

    2014-01-01

    Summary Action potentials trigger synchronous and asynchronous neurotransmitter release. Temporal properties of both types of release could be altered in an activity-dependent manner. While the effects of activity-dependent changes in synchronous release on postsynaptic signal integration have been studied, the contribution of asynchronous release to information transfer during natural stimulus patterns is unknown. Here we find that during trains of stimulations, asynchronous release contributes to the precision of action potential firing. Our data show that this form of release is selectively diminished in AP-3b2 KO animals, which lack functional neuronal AP-3, an adaptor protein regulating vesicle formation from endosomes generated during bulk endocytosis. We find that in the absence of neuronal AP-3, asynchronous release is attenuated and the activity-dependent increase in the precision of action potential timing is compromised. Lack of asynchronous release decreases the capacity of synaptic information transfer and renders synaptic communication less reliable in response to natural stimulus patterns. PMID:25410111

  5. PRESS RELEASE FROM MOLECULAR PSYCHIATRY This press release is copyright Nature Publishing Group. Please cite Molecular Psychiatry and the article's URL as

    E-print Network

    Cai, Long

    PRESS RELEASE FROM MOLECULAR PSYCHIATRY This press release is copyright Nature Publishing Group. Please cite Molecular Psychiatry and the article's URL as the source of the following item. High BMI, reports a paper in Molecular Psychiatry. Specifically, the research found that each unit increase in body

  6. PRESS RELEASE FROM MOLECULAR PSYCHIATRY This press release is copyright Nature Publishing Group. Please cite Molecular Psychiatry and the article's URL as

    E-print Network

    Cai, Long

    PRESS RELEASE FROM MOLECULAR PSYCHIATRY This press release is copyright Nature Publishing Group. Please cite Molecular Psychiatry and the article's URL as the source of the following item. Mental health in Molecular Psychiatry this week. The study suggests that a factor common to all mental health disorders may

  7. Disruption of adaptor protein 2? (AP-2?) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing.

    PubMed

    Jung, SangYong; Maritzen, Tanja; Wichmann, Carolin; Jing, Zhizi; Neef, Andreas; Revelo, Natalia H; Al-Moyed, Hanan; Meese, Sandra; Wojcik, Sonja M; Panou, Iliana; Bulut, Haydar; Schu, Peter; Ficner, Ralf; Reisinger, Ellen; Rizzoli, Silvio O; Neef, Jakob; Strenzke, Nicola; Haucke, Volker; Moser, Tobias

    2015-11-01

    Active zones (AZs) of inner hair cells (IHCs) indefatigably release hundreds of vesicles per second, requiring each release site to reload vesicles at tens per second. Here, we report that the endocytic adaptor protein 2? (AP-2?) is required for release site replenishment and hearing. We show that hair cell-specific disruption of AP-2? slows IHC exocytosis immediately after fusion of the readily releasable pool of vesicles, despite normal abundance of membrane-proximal vesicles and intact endocytic membrane retrieval. Sound-driven postsynaptic spiking was reduced in a use-dependent manner, and the altered interspike interval statistics suggested a slowed reloading of release sites. Sustained strong stimulation led to accumulation of endosome-like vacuoles, fewer clathrin-coated endocytic intermediates, and vesicle depletion of the membrane-distal synaptic ribbon in AP-2?-deficient IHCs, indicating a further role of AP-2? in clathrin-dependent vesicle reformation on a timescale of many seconds. Finally, we show that AP-2 sorts its IHC-cargo otoferlin. We propose that binding of AP-2 to otoferlin facilitates replenishment of release sites, for example, via speeding AZ clearance of exocytosed material, in addition to a role of AP-2 in synaptic vesicle reformation. PMID:26446278

  8. PRESS RELEASE Charles University in Prague opens its doors wide to the world -computer science

    E-print Network

    Cerveny, Vlastislav

    PRESS RELEASE Charles University in Prague opens its doors wide to the world - computer science taught in English (press release) Prague, 3 December 2012 ­ Faculty of Mathematics and Physics, Charles course in computer science in English. In 1952, when the Faculty of Mathematics and Physics, Charles

  9. The association between exaggeration in health related science news and academic press releases: retrospective observational study

    PubMed Central

    Vivian-Griffiths, Solveiga; Boivin, Jacky; Williams, Andy; Venetis, Christos A; Davies, Aimée; Ogden, Jack; Whelan, Leanne; Hughes, Bethan; Dalton, Bethan; Boy, Fred

    2014-01-01

    Objective To identify the source (press releases or news) of distortions, exaggerations, or changes to the main conclusions drawn from research that could potentially influence a reader’s health related behaviour. Design Retrospective quantitative content analysis. Setting Journal articles, press releases, and related news, with accompanying simulations. Sample Press releases (n=462) on biomedical and health related science issued by 20 leading UK universities in 2011, alongside their associated peer reviewed research papers and news stories (n=668). Main outcome measures Advice to readers to change behaviour, causal statements drawn from correlational research, and inference to humans from animal research that went beyond those in the associated peer reviewed papers. Results 40% (95% confidence interval 33% to 46%) of the press releases contained exaggerated advice, 33% (26% to 40%) contained exaggerated causal claims, and 36% (28% to 46%) contained exaggerated inference to humans from animal research. When press releases contained such exaggeration, 58% (95% confidence interval 48% to 68%), 81% (70% to 93%), and 86% (77% to 95%) of news stories, respectively, contained similar exaggeration, compared with exaggeration rates of 17% (10% to 24%), 18% (9% to 27%), and 10% (0% to 19%) in news when the press releases were not exaggerated. Odds ratios for each category of analysis were 6.5 (95% confidence interval 3.5 to 12), 20 (7.6 to 51), and 56 (15 to 211). At the same time, there was little evidence that exaggeration in press releases increased the uptake of news. Conclusions Exaggeration in news is strongly associated with exaggeration in press releases. Improving the accuracy of academic press releases could represent a key opportunity for reducing misleading health related news. PMID:25498121

  10. EXPOSURE AND RELEASE ESTIMATIONS FOR FILTER PRESS AND TRAY DRYER OPERATIONS BASED ON PILOT PLANT DATA

    EPA Science Inventory

    Worker exposures and chemical releases associated with a plate-and-frame filter press and a stationary tray dryer were studied in a pilot plant. he equipment was representative of those in a chemical manufacturing plant; the filter press was previously used at a chemical plant, a...

  11. ApJ, in press November 3, 2013 The density of mid-sized Kuiper belt object 2002 UX25 and the

    E-print Network

    Brown, Michael E.

    ApJ, in press November 3, 2013 The density of mid-sized Kuiper belt object 2002 UX25 in the Kuiper belt, with measured den- sities of 1.5 g cm-3 and higher, from the coagulation of small bodies for diameters larger than 350 km. In the Kuiper belt, no density measurements have been made between 350 km

  12. LIST OF ETV ARTICLES AND PRESS RELEASES--ETV PUBLICATIONS AND DOCUMENTS (ENVIRONMENTAL TECHNOLOGY VERIFICATION (ETV) PROGRAM)

    EPA Science Inventory

    The Environmental Technology Verification (ETV) Program produces articles and press releases related to the ETV program. This list of ETV articles and press releases will help readers stay informed of developments in the ETV Program.To view the complete list of articles and pre...

  13. Biosensors Group wins Nokia Open Innovation Challenge 2015 IMBBFORTH, Press release

    E-print Network

    Gizeli, Electra

    Biosensors Group wins Nokia Open Innovation Challenge 2015 IMBBFORTH, Press release 1 Biosensors Group is one of the winners in NOKIA Open Innovation Challenge 2015 The Biosensors Group". Within the above philosophy, the Biosensors group was awarded for presenting a new concept

  14. NATIONAL PRESS RELEASE I PARIS I 24 MARCH 2015 Combining magnetism and light to fight cancer

    E-print Network

    NATIONAL PRESS RELEASE I PARIS I 24 MARCH 2015 Combining magnetism and light to fight cancer By combining, in a liposome 1 , magnetic nanoparticles and photosensitizers that are simultaneously and remotely activated by external physical stimuli (a magnetic field and light), scientists at the Laboratoire

  15. PRESS RELEASES OF SENATOR PETE DOMENICI Domenici Supports 12 Percent Increase for Nuclear Energy, Disputes Fusion

    E-print Network

    PRESS RELEASES OF SENATOR PETE DOMENICI Domenici Supports 12 Percent Increase for Nuclear Energy his support for a 12 percent increase in federal funding for nuclear energy research, but challenged of modern nuclear power plants. Domenici is chairman of the Energy and Water Development Appropriations

  16. Corporate Responsibility in Communication: Empirical Analysis of Press Releases in a Conflict

    ERIC Educational Resources Information Center

    Lehtimaki, Hanna; Kujala, Johanna; Heikkinen, Anna

    2011-01-01

    The paper examines how the tensions of corporate responsibility are articulated and reconciled in a controversial situation of a foreign investment. We conducted a conventionalist analysis on the company press releases in a case where a Finnish forest industry company invested in a pulp mill in South America. The findings show that the use of…

  17. Press Release Monday October 5th, 2009 UHM Scientists Spark Aerospace in Hawaii

    E-print Network

    Press Release Monday October 5th, 2009 UHM Scientists Spark Aerospace in Hawaii Week Researchers from the School of Ocean and Earth Sciences and Technology at the University of Hawaii at Manoa will participate in lively panel discussions this week as part of Aerospace Week in Hawaii. All presentations

  18. Press Release Money for study abroad: dreams come true for many

    E-print Network

    Press Release Money for study abroad: dreams come true for many students ­ more than 6 million to money issues. "Not everyone can afford, the often, expen- sive time abroad". says Anja Hofmann, member about money matters. For a long time, we could only recommend Auslands-BAföG and scholarships

  19. engineering home news home press releases subscribe to e-news Dr. J. C. Chiao

    E-print Network

    Chiao, Jung-Chih

    sear engineering home news home press releases subscribe to e-news Dr. J. C. Chiao Pain Management components, to provide additional support for their research to develop pain management systems. Electrical an integrated, low-power, wireless body networking system to address the complex issues in managing chronic pain

  20. Press Release Von Roll Inova to build the UK's largest energy-from-waste

    E-print Network

    Columbia University

    Press Release Von Roll Inova to build the UK's largest energy-from-waste plant Zürich, September, 1 Roll Inova will build the UK's largest energy-from-waste facility. The contract is worth approximately and energy recovery. Apart from building and commissioning the plant, Von Roll Inova's scope of delivery also

  1. Press release: 5 November 2014 Curating Cambridge: our city, our stories, our stuff

    E-print Network

    parks, streets and buildings across Cambridge. " If you're interested in the history of CambridgePress release: 5 November 2014 Curating Cambridge: our city, our stories, our stuff 20 October ­ 23 November 2014 Half way through, still lots to do! Curating Cambridge: our city, our stories, our stuff has

  2. Chorum Press Releases Page 1 of 2 http://www.chorumtech.com/news-releases/NewsReviews_jc.poster.htm 2/25/2002

    E-print Network

    Chiao, Jung-Chih

    Chorum Press Releases Page 1 of 2 http://www.chorumtech.com/news-releases/NewsReviews_jc.poster.htm 2/25/2002 FOR IMMEDIATE RELEASE CHORUM TECHNOLOGIES' DR. J.C. CHIAO TO PRESENT PAPER IN THE POSTER WHAT: Dr. J.C. Chiao from Chorum Technologies in Richardson, Texas, will present a paper in the poster

  3. Press-coated tablets for time-programmed release of drugs.

    PubMed

    Conte, U; Maggi, L; Torre, M L; Giunchedi, P; La Manna, A

    1993-10-01

    A new dry-coated device for the release of drug after a programmable period of time is proposed. It is intended to be used mainly in the therapy of those diseases which depend on circadian rhythms. Some core formulations, characterized by different release rates and mechanisms (containing diltiazem hydrochloride or sodium diclofenac as model drugs), were coated by compression with different polymeric barrier layers (press-coated systems). The shell formulations tested contained either gellable or erodible polymers. The dissolution profiles of uncoated cores and press-coated devices were compared. The gellable and/or erodible characteristics (properties) of the barrier formulations were also examined by means of a penetrometer. The coatings prevent drug release from the core until the polymeric shell is completely eroded or swollen. This delay in release start is not influenced by the core composition and depends only on the shell formulation. Except for the time-lag, the release kinetics of the drug contained in the core are not significantly influenced by the presence of the erodible barrier, but can be widely modulated using a swellable polymeric shell. PMID:8286668

  4. Neuron, Vol. 40, 971982, December 4, 2003, Copyright 2003 by Cell Press ATP Released by Astrocytes Mediates

    E-print Network

    Newman, Eric A.

    Neuron, Vol. 40, 971­982, December 4, 2003, Copyright 2003 by Cell Press ATP Released by Astrocytes Mediates Glutamatergic Activity-Dependent Heterosynaptic Suppression ATP release and synaptic modulation by exogenous ATP have been widely reported, the endogenous source of ATP responsible for synaptic modulation

  5. Loss of AP-3 function affects spontaneous and evoked release at hippocampal mossy fiber synapses

    E-print Network

    Danglot, Lydia - Institut Jacques Monod, Université Paris 7

    -dependent tetanus neurotox- in-resistant asynchronous release that can be evoked at hippocam- pal mossy fiber (MF) synapses. Presynaptic targeting of the tetanus neurotoxin-resistant vesicle soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) tetanus neurotoxin- insensitive vesicle-associated membrane

  6. "Discoveries in Planetary Sciences": Turning Press Release Science into Teachable Moments in Higher Ed

    NASA Astrophysics Data System (ADS)

    Schneider, N. M.; Brain, D.; Sada, P. V.

    2011-12-01

    AGU disciplines are all fields that evolve rapidly, and it can take several years for new advances to work their way into college textbooks. Yet it is important for students to have exposure to these new advances for a number of reasons. In some cases, new work renders older textbook knowledge incorrect or incomplete. In some cases, new discoveries make it possible to emphasize older textbook knowledge in a new way. In all cases, new advances provide exciting and accessible examples of the scientific process in action. But press releases rarely provide these "teachable moments" in either content or format. To bridge the gap between textbooks and new advances in planetary sciences, we have developed content on new discoveries for use by undergraduate instructors. Called 'Discoveries in Planetary Sciences', each new discovery is summarized in a 3-slide PowerPoint presentation. The first slide describes the discovery, the second slide discusses the underlying planetary science concepts, and the third presents the big picture implications of the discovery. A fourth slide includes links to associated press releases, images, and primary sources. This effort is generously sponsored by the Division for Planetary Sciences of the American Astronomical Society, and the slide sets are available at http://dps.aas.org/education/dpsdisc/. More than twenty slide sets have been released so far covering topics spanning all sub-disciplines of planetary science, with a fall release planned for Spanish translations In this presentation we will discuss our motivation for this project, our implementation approach (from choosing topics to creating the slide sets, to getting them reviewed and released), and give examples of slide sets. We will present information in the form of web statistics on how many educators are using the slide sets, and which topics are most popular. We will also present feedback from educators who have used them in the classroom. The value and popularity of these slide sets in planetary science makes an excellent case for expansion to all AGU disciplines.

  7. The rural restaurant healthy options program: response of rural, local newspapers to a program press release.

    PubMed

    Nothwehr, Faryle; Andsager, Julie; Haines, Heidi

    2014-03-01

    Local media should be used to raise awareness of health promotion programs. In rural areas, local newspapers provide an opportunity to reach large numbers of residents. Although there are expert guidelines describing the process for successfully engaging local media, little has been documented regarding the range of responses that local, rural newspapers might have when approached about covering health promotion programs. This study describes the response of rural, local newspapers to a press release about a health promotion program taking place in 28 restaurants in different rural towns. The most common reason for not publishing a story was that it would constitute free advertising for the restaurant. Twenty-two stories were analyzed using descriptive statistics. The majority of the responding newspapers were weeklies, and 16 published the full press release verbatim. Three stories included photos, and five included quotes. Headlines typically included the name of the restaurant and the university partner. The overall response rate is encouraging; however, there is considerable room for improvement in terms of personalizing the story with photos or quotes. Greater efforts may be required to obtain this depth of coverage, including training for local journalists to increase their interest and confidence in covering health promotion issues. PMID:23182860

  8. The Rural Restaurant Healthy Options Program: Response of Rural, Local Newspapers to a Program Press Release

    PubMed Central

    Nothwehr, Faryle; Andsager, Julie; Haines, Heidi

    2014-01-01

    Local media should be used to raise awareness of health promotion programs. In rural areas, local newspapers provide an opportunity to reach large numbers of residents. Although there are expert guidelines describing the process for successfully engaging local media, little has been documented regarding the range of responses that local, rural newspapers might have when approached about covering health promotion programs. This study describes the response of rural, local newspapers to a press release about a health promotion program taking place in 28 restaurants in different rural towns. The most common reason for not publishing a story was that it would constitute free advertising for the restaurant. Twenty-two stories were analyzed using descriptive statistics. The majority of the responding newspapers were weeklies, and 16 published the full press release verbatim. Three stories included photos, and five included quotes. Headlines typically included the name of the restaurant and the university partner. The overall response rate is encouraging; however, there is considerable room for improvement in terms of personalizing the story with photos or quotes. Greater efforts may be required to obtain this depth of coverage, including training for local journalists to increase their interest and confidence in covering health promotion issues. PMID:23182860

  9. PRESS RELEASE / PRESS RELEASE / PRESS RELEASE / PRESS RELEASE / PRESS RELEASE / PRESS RELEASE Ecole Centrale Paris

    E-print Network

    Paragios, Nikos

    Centrale Paris Grande Voie des Vignes - 92295 Châtenay-Malabry Cedex Tél +33 1://twitter.com/centraleparis Centrale Paris, Supélec and Politecnico di Milano commit to enhance strategic cooperation (Milano, Paris, January 27, 2014) Ecole Centrale Paris, Supélec and Politecnico di Milano have decided to embark upon

  10. Coverage of Team Science by Public Information Officers: Content Analysis of Press Releases about the National Science Foundation Science and Technology Centers

    ERIC Educational Resources Information Center

    Graube, Marita; Clark, Fiona; Illman, Deborah L.

    2010-01-01

    This study examines the content of press releases from the National Science Foundation (NSF) Science and Technology Centers (STCs) to determine how public information officers (PIOs) presented the outcomes of centers to journalists and the public. A total of 68 press releases were analyzed for type of news covered, visibility of centers and their…

  11. IDARM PRESS RELEASE: IDARM conducts "Logistics and Life Cycle Management" course during 2629 May 2015 in Bogota,

    E-print Network

    IDARM PRESS RELEASE: IDARM conducts "Logistics and Life Cycle Management" course during 2629 May) program within the Center for CivilMilitary Relations (CCMR) conducted a "Logistics and Life Cycle and characteristics of effective logistics and life cycle management systems. Emphasis was placed on best

  12. PRESS RELEASE May 15, 2013, 10:12 a.m. ET Raw Cotton Absorbs Crude Oil Spills; Repels Water

    E-print Network

    Rock, Chris

    PRESS RELEASE May 15, 2013, 10:12 a.m. ET Raw Cotton Absorbs Crude Oil Spills; Repels Water NEW is highly effective at absorbing crude oil spills. The study, published in the most recent issue material for addressing ocean-based oil spills. The study was supported in part by Cotton Incorporated

  13. Nanotechnology Now -Press Release: "Researchers directly deposit gold nanoparticles in suspension" Web www.nanotech-now.com

    E-print Network

    Espinosa, Horacio D.

    Nanotechnology Now - Press Release: "Researchers directly deposit gold nanoparticles in suspension such as metal nanoparticles into predefined architectures and patterns is of great interest in nanotechnology or in plasmon waveguides to guide the transport of electromagnetic energy below the diffraction limit

  14. PRESS RELEASE I PARIS I 10 DECEMBER 2014 First measurements by the Rosetta mission's ROSINA instrument show that the deuterium-

    E-print Network

    PRESS RELEASE I PARIS I 10 DECEMBER 2014 First measurements by the Rosetta mission's ROSINA and oceans has a cometary origin. They also indicate that 67P comets do not all come from one region falls within the range of the D/H ratio of asteroids located between Mars and Jupiter, the water

  15. Development and optimization of press coated tablets of release engineered valsartan for pulsatile delivery.

    PubMed

    Shah, Sunny; Patel, Romik; Soniwala, Moinuddin; Chavda, Jayant

    2015-11-01

    The present work is aimed to develop and optimize pulsatile delivery during dissolution of an improved formulation of valsartan to coordinate the drug release with circadian rhythm. Preliminary studies suggested that ? cyclodextrin could improve the solubility of valsartan and showed AL type solubility curve. A 1:1 stoichiometric ratio of valsartan to ? cyclodextrin was revealed from phase solubility studies and Job's plot. The prepared complex showed significantly better dissolution efficiency (p?press-coated tablets of valsartan ? cyclodextrin complex were subsequently prepared and application of the Plackett-Burman screening design revealed that HPMC K4M and EC showed significant effect on lag time. A 3(2) full factorial design was used to measure the response of HPMC K4M and EC on lag time and time taken for 90% drug release (T90). The optimized batch prepared according to the levels obtained from the desirability function had a lag time of 6?h and consisted of HPMC K4M:ethylcellulose in a 1:1.5 ratio with 180?mg of coating and revealed a close agreement between observed and predicted value (R(2?)=?0.9694). PMID:25721985

  16. Below is an excerpt from a press release from the United Nations Assistance Mission in Afghanistan (UNAMA) that describes the current situation of Sunn Pest in two districts

    E-print Network

    Vermont, University of

    Below is an excerpt from a press release from the United Nations Assistance Mission in Afghanistan (UNAMA) that describes the current situation of Sunn Pest in two districts of Afghanistan. Press briefing by Richard Provencher, Public Information Officer and UN agencies in Afghanistan 26 May 2005 ..... Sunn Pest

  17. 76 FR 6328 - Official Release of the January 2011 AP-42 Method for Estimating Re-Entrained Road Dust From...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-04

    ... emissions model for SIPs and regional conformity purposes (75 FR 9411) and of the MOVES2010a and EMFAC models for transportation conformity hot-spot analyses (75 FR 79370). The January 2011 AP-42 method... grace period in the preamble to the 1993 transportation conformity rule (58 FR 62211): EPA and DOT...

  18. Transcriptional regulation of monocyte chemotactic protein-1 release by endothelin-1 in human airway smooth muscle cells involves NF-?B and AP-1

    PubMed Central

    Sutcliffe, Amy M; Clarke, Deborah L; Bradbury, Dawn A; Corbett, Lisa M; Patel, Jamie A; Knox, Alan J

    2009-01-01

    Background and purpose: Endothelin-1 (ET-1) is implicated in airway inflammation in asthma, but the mechanisms of its effects are poorly understood. We studied the effect of ET-1 on expression of the chemokine, monocyte chemotactic protein-1 (MCP-1), in primary cultures of human airway smooth muscle cells. Experimental approach: MCP-1 release was measured by elisa. Pharmacological antagonists/inhibitors, reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blotting were used to study ET receptors and kinase cascades. Transcriptional regulation was studied by real-time RT-PCR, transient transfection studies and chromatin immunoprecipitation assay. Major findings were confirmed in cells from three donors and mechanistic studies in cells from one donor. Key results: ET-1 increased MCP-1 release through an ETA and ETB receptor-dependent mechanism. ET-1 increased MCP-1 mRNA levels but not mRNA stability suggesting it was acting transcriptionally. ET-1 increased the activity of an MCP-1 promoter–reporter construct. Serial deletions of the MCP-1 promoter mapped ET-1 effects to a region between ?213 and ?128 base pairs upstream of the translation start codon, containing consensus sequences for activator protein-1 (AP-1) and nuclear factor-?B (NF-?B). ET-1 promoted binding of AP-1 c-Jun subunit and NF-?B p65 subunit to the MCP-1 promoter. Blocking the inhibitor of ?B kinase-2 with 2-[(aminocarbonyl)amino]-5-[4-fluorophenyl]-3-thiophenecarboxamide (TPCA-1) decreased ET-1-stimulated MCP-1 production. p38 and p44/p42 mitogen-activated protein kinases were involved in upstream signalling. Conclusions and implications: ET-1 regulated MCP-1 transcriptionally, via NF-?B and AP-1. The upstream signalling involved ETA, ETB receptors, p38 and p44/p42 mitogen-activated protein kinases. These may be targets for novel asthma therapies. PMID:19371341

  19. EVALUATION OF CHEMICAL RELEASES AND WORKER EXPOSURES FROM FILTER PRESS OPERATIONS

    EPA Science Inventory

    The exposures (inhalation and dermal) and releases (air, water, solids, and process streams) associated with the filtration of industrial wastewater sludge from an electronics manufacturing plant were characterized. hemical releases and worker exposures for a target chemical (tot...

  20. EVALUATION OF CHEMICAL RELEASES AND WORKER EXPOSURES FROM FILTER PRESS OPERATIONS

    EPA Science Inventory

    The exposures (inhalation and dermal) and releases (air, water, solids, and process streams) associated with the filtration of industrial wastewater sludge from an electronics manufacturing plant were characterized. Chemical releases and worker exposures for a target chemical (t...

  1. When Medical News Comes from Press Releases—A Case Study of Pancreatic Cancer and Processed Meat

    PubMed Central

    Taylor, Joseph W.; Long, Marie; Ashley, Elizabeth; Denning, Alex; Gout, Beatrice; Hansen, Kayleigh; Huws, Thomas; Jennings, Leifa; Quinn, Sinead; Sarkies, Patrick; Wojtowicz, Alex; Newton, Philip M.

    2015-01-01

    The media have a key role in communicating advances in medicine to the general public, yet the accuracy of medical journalism is an under-researched area. This project adapted an established monitoring instrument to analyse all identified news reports (n = 312) on a single medical research paper: a meta-analysis published in the British Journal of Cancer which showed a modest link between processed meat consumption and pancreatic cancer. Our most significant finding was that three sources (the journal press release, a story on the BBC News website and a story appearing on the ‘NHS Choices’ website) appeared to account for the content of over 85% of the news stories which covered the meta analysis, with many of them being verbatim or moderately edited copies and most not citing their source. The quality of these 3 primary sources varied from excellent (NHS Choices, 10 of 11 criteria addressed) to weak (journal press release, 5 of 11 criteria addressed), and this variance was reflected in the accuracy of stories derived from them. Some of the methods used in the original meta-analysis, and a proposed mechanistic explanation for the findings, were challenged in a subsequent commentary also published in the British Journal of Cancer, but this discourse was poorly reflected in the media coverage of the story. PMID:26083640

  2. 9/6/12 Press Releases | Embassy of the United States 1/4newdelhi.usembassy.gov/pr090512.html

    E-print Network

    Arnold, Jonathan

    9/6/12 Press Releases | Embassy of the United States 1/4newdelhi.usembassy.gov/pr090512.html 1/4newdelhi.usembassy.gov/pr090512.html nearly seven lakh nonimmigrant visa applications, an increase of more

  3. NATIONAL PRESS RELEASE I PARIS I 10 JUNE 2015 Rapidly detecting the presence of pathogenic bacteria is essential in a number of sectors,

    E-print Network

    van Tiggelen, Bart

    by concentrating the bacteria (E. coli) present in a sample. To achieve this, they applied the simple principle such as Escherichia coli or Salmonella typhimurium are Gram-negative bacteria. 2 An innovative chemical methodNATIONAL PRESS RELEASE I PARIS I 10 JUNE 2015 Rapidly detecting the presence of pathogenic bacteria

  4. PRESS RELEASE I PARIS I 14 OCTOBER 2015 Using data from 46 experiments on grassland plant diversity, an international team of

    E-print Network

    Matias, Catherine

    PRESS RELEASE I PARIS I 14 OCTOBER 2015 Using data from 46 experiments on grassland plant diversity study, the researchers therefore used data from 46 experiments on grassland plant diversity in order does indeed increase the resistance of grassland primary productivity1 for a broad range of climate

  5. engineering home news home press releases subscribe to e-news annual re UT Arlington Moving Ideas from Laboratories to Marketplace

    E-print Network

    Chiao, Jung-Chih

    sear engineering home news home press releases subscribe to e-news annual re UT Arlington Moving-effective Surface Texture on Solar Cells Electrical Engineering Associate Professor Meng Tao and Assistant Professor Weidong Zhou have developed a unique process that should reduce the cost of solar-generated electricity

  6. NATIONAL PRESS RELEASE I PARIS I 22 MAY 2013 A new way of tackling cancer and predicting tumor virulence are has been reported by a

    E-print Network

    Pouyanne, Nicolas

    NATIONAL PRESS RELEASE I PARIS I 22 MAY 2013 A new way of tackling cancer and predicting tumor physicians and anatomopathologists from the CHU de Grenoble, with the support of the Institut National du Cancer, the Ligue Nationale Contre le Cancer and the Fondation ARC pour la Recherche sur le Cancer

  7. Press release embargoed until 6.00am Thursday 22 August 2013 Find a 3D fossil the hunt is on!

    E-print Network

    Press release ­ embargoed until 6.00am Thursday 22 August 2013 Find a 3D fossil ­ the hunt is on Geological Survey that will see fossil types freely available to all. They are also running a competition County Museum. The `type' specimen of a fossil is the one to which all other similar specimens

  8. OFFICIAL POLICY 3.7.1 Media Relations: Press Releases and Statements 07/01/09

    E-print Network

    Kunkle, Tom

    of sports information, which is supervised by the Athletics Direcor ­ must be released through the Office of Media Relations in the Division of Marketing and Communications. The Office of Media Relations must Relations in the Division of Marketing and Communications

  9. 2014 PMEL Lab Review PMEL Press Releases and NOAA News Stories

    E-print Network

    Stories FY09-FY14 PMEL WIDE Oceanographer named to head NOAA's Seattle research laboratory http://www.noaanews.noaa.gov/stories2011/20111018_pmel.html CLIMATE THEME ­ most recent releases and stories listed first Carbon dioxide in the tropical

  10. About Us Contact Us Site Map Privacy Statement Terms of Use 2009 Business Wire More Business Wire sites: Business Wired blog Canada UK/Ireland Deutschland France Italy Japan EON Online Press Release Tradeshownews.com

    E-print Network

    Aksay, Ilhan A.

    sites: Business Wired blog Canada UK/Ireland Deutschland France Italy Japan EON Online Press Release conductive, versatile, and low-cost, conductive ink, for commercial sale to the printed electronics industry

  11. Press Release FOR IMMEDIATE RELEASE

    E-print Network

    Azevedo, Ricardo

    @central.uh.edu RESIDENCE HALLS GET NEW HIGH-TECH MACHINES IN LAUNDRY ROOMS Houston, June 7, 2012 ­ Not only will residents enjoy free and unlimited use of laundry equipment when they arrive in the fall, but they will also efficiency washers and dryers with LaundryView® technology. With this technology, residents can visit

  12. PRESS RELEASE FOR IMMEDIATE RELEASE

    E-print Network

    Chiao, Jung-Chih

    severe acid reflux that can lead to cancer. Other devices developed by Dr. Chiao include a battery less models for nurturing and sustaining innovation. The Edith and Peter O'Donnell Awards annually recognize

  13. Press Release IMMEDIATE RELEASE CONTACT

    E-print Network

    Alford, Simon

    gathered in NHANES to develop sound health policies, direct and design health programs and services-Green, MD, MHPE. Centers for Disease Control and Prevention #12;Everyone in the U.S., from babies yet

  14. Press Release FOR IMMEDIATE RELEASE

    E-print Network

    Azevedo, Ricardo

    to the Housing Fair on March 20- 21 to discover housing options and see how living on campus can elevate are interested in living on campus can take this opportunity to stop by and speak to RLH staff to see which on-campus, cotton candy and drinks as they take in their housing options and enjoy the festivities. Students who

  15. Landslide incidence in the North of Portugal: Analysis of a historical landslide database based on press releases and technical reports

    NASA Astrophysics Data System (ADS)

    Pereira, Susana; Zêzere, José Luís; Quaresma, Ivânia Daniela; Bateira, Carlos

    2014-06-01

    This work presents and explores the Northern Portugal Landslide Database (NPLD) for the period 1900-2010. NPLD was compiled from press releases (regional and local newspapers) and technical reports (reports by civil protection authorities and academic works); it includes 628 landslides, corresponding to 5.7 landslides per year on average. Although 50% of landslides occurred in the last 35 years of the series, the temporal distribution of landslides does not show any regular increase with time. The relationship between annual precipitation and landslide occurrence shows that reported landslides tend to be more frequent in wetter years. Moreover, landslides occur mostly in the wettest months of the year (December, January and February), which reflects the importance of rainfall in triggering slope instability. Most landslides cause damage that affects people and/or structures; 69.4% of the landslides in Northern Portugal caused 136 fatalities, 173 injured and left 460 persons homeless. More than half of the total landslides (321 landslides) led to railway or motorway closures and 49 landslides destroyed 126 buildings. The NPLD is compared with a landslide database for the whole of Portugal constructed from a single daily national newspaper covering the same reference period. It will be demonstrated that the regional and local newspapers are more effective than the national newspaper in reporting damaging landslides in the North of Portugal. Like other documentary-based landslide inventories, the NPLD does not accurately report non-damaging landslides. Therefore, NPLD was found unsuitable to validate municipal-scale landslide susceptibility models derived from detailed geomorphology-based landslide inventories.

  16. Pycnogenol Attenuates the Release of Proinflammatory Cytokines and Expression of Perilipin 2 in Lipopolysaccharide-Stimulated Microglia in Part via Inhibition of NF-?B and AP-1 Activation

    PubMed Central

    Fan, Bin; Dun, Sai-Hong; Gu, Jian-Qiu; Guo, Yang; Ikuyama, Shoichiro

    2015-01-01

    Over activation of microglia results in the production of proinflammatory agents that have been implicated in various brain diseases. Pycnogenol is a patented extract from French maritime pine bark (Pinus pinaster Aiton) with strong antioxidant and anti-inflammatory potency. The present study investigated whether pycnogenol may be associated with the production of proinflammatory mediators in lipopolysaccharide-stimulated BV2 (mouse-derived) microglia. It was found that pycnogenol treatment was dose-dependently associated with significantly less release of nitricoxide (NO), TNF-?, IL-6 and IL-1?, and lower levels of intercellular adhesion molecule1 (ICAM-1) and perilipin 2 (PLIN2). Furthermore, this effect was replicated in primary brain microglia. Levels of inducible NO synthase mRNA and protein were attenuated, whereas there was no change in the production of the anti-inflammatory cytokine IL-10. Further evidence indicated that pycnogenol treatment led to the suppression of NF-?B activation through inhibition of p65 translocation into the nucleus and inhibited DNA binding of AP-1, suggesting that these proinflammatory factors are associated with NF-?B and AP-1. We conclude that pycnogenol exerts anti-inflammatory effects through inhibition of the NF-?B and AP-1pathway, and may be useful as a therapeutic agent in the prevention of diseases caused by over activation of microglia. PMID:26367267

  17. Public Relations Press Release

    E-print Network

    Ould Ahmedou, Mohameden

    can dream of. With many strong emotions, an exciting crime drama, a message for our time and thus many opportunities for my expressive music to present itself in its full width." Under the creative direction that is appropriate to your medium." "The project is an incredible creative challenge," says Amelung. Wallander

  18. PRESS RELEASES WIFI ALLIANCE

    E-print Network

    Chiao, Jung-Chih

    animal testing on an RFID-based system to replace the wired sensor currently used to diagnose to conduct testing on living animals this summer and on humans by fall of this year. The device uses condition wirelessly. Currently, acid reflux testing requires an uncomfortable procedure that makes it very

  19. PRESS RELEASE FROM NEUROPSYCHOPHARMACOLOGY

    E-print Network

    Cai, Long

    , and examined the insula using magnetic resonance imaging (MRI) in 16­22-year-old participants. 24 participants Services and Markets Act 2000 and the US Securities Exchange Act of 1934, each of which may be subject to penalties and imprisonment. PICTURES: While we are happy for images from Neuropsychopharmacology

  20. Public Relations Press Release

    E-print Network

    Ould Ahmedou, Mohameden

    such learning tasks. Their findings are published in the latest Proceedings of the National Academy of Sciences neuronal representations of upcoming behavioral choices in crows. Proceedings of the National Academy of Sciences of the USA. Online Early Edition, Nov 23-27, 2015. http

  1. PRESS RELEASE / PRESS RELEASE / PRESS RELEASE / PRESS RELEASE TheEcoleCentraleParisstrengthensitsexpansiontowardstheSME

    E-print Network

    Paragios, Nikos

    PariscampusonMarch13.BringingtogethertheSchool'sstudentsand25SmallandEcoleCentraleParisclearlyshowthatthereisanincreasinginterestexpressedbystudentsfor these companies: 25% of students are attracted by entrepreneurship; 30% believe that working in an SME offersCentraliansoftheverywiderangeofactivitiescoveredbySMEandthewealthofprofessionalcareers availablethroughstudentprojects,internships,companypresentationsandprofessionaladvisors. Inthisframework,thefirst"Meeting with

  2. PRESSMEDDELANDE Press release

    E-print Network

    Adler, Joan

    15 56 70, INFO@KVA.SE HTTP://KVA.SE BESÖK/VISIT: LILLA FRESCATIVÄGEN 4A, SE-114 18 STOCKHOLM, SWEDEN In quasicrystals, we find the fascinating mosaics of the Arabic world reproduced at the level of atoms: regular solid matter, atoms were believed to be packed inside crystals in symmetrical patterns that were

  3. Press Release - Dec 1995

    Cancer.gov

    Mortality data have shown for several decades that breast cancer death rates are higher in the Northeast than in other regions of the country, particularly the South. But the new analysis demonstrates that the Northeast, Midwest, and West have a similar mortality risk after taking into account factors such as age at first live birth. Moreover, the differences between these regions and the South narrowed after accounting for such factors.

  4. PRESS RELEASE / PRESS RELEASE / PRESS RELEASE / PRESS RELEASE Herv Biausser, Director of the Ecole Centrale Paris,

    E-print Network

    Paragios, Nikos

    Centrale Paris, Has been nominated Director General of Supélec (Paris, September 2, 2013) ­ As previously Biausser has been reappointed has Director of Ecole Centrale Paris for a third term, as of September 1st, at the south of Paris, in Gif-sur-Yvette where two new buildings will be built by Centrale Paris (by 2017) near

  5. PRESS RELEASE FROM NEUROPSYCHOPHARMACOLOGY

    E-print Network

    Cai, Long

    ). For more information about DOIs and Advance Online Publication, see http://www.nature.com/ng/aop/. HYPE: We AS THE SOURCE OF THE FOLLOWING ITEMS. IF PUBLISHING ONLINE, PLEASE CARRY A HYPERLINK TO THE APPROPRIATE JOURNAL.1038/NPP.2013.201 A protein associated with HIV infection may increase vulnerability for cocaine abuse

  6. PRESS RELEASE Kehrwieder 12

    E-print Network

    electric and magnetic fields. In addition, the magnetic ordering in these crystals can be influenced energy-efficient computers of the future. Multiferroics, which are compounds of metals and oxygen, could. The multiferroics created by the prize winner ­ the majority of these crystals do not occur naturally ­ owe

  7. 3/4/13 FBI --Eighteen People Charged in International $200 Million Credit Card Fraud Scam www.fbi.gov/newark/press-releases/2013/eighteen-people-charged-in-international-200-million-credit-card-fraud-scam 1/3

    E-print Network

    Sandhu, Ravi

    3/4/13 FBI -- Eighteen People Charged in International $200 Million Credit Card Fraud Scam www.fbi.gov/newark/press-releases/2013/eighteen-people-charged-in-international-200-million-credit-card-fraud-scam 1/3 Eighteen People Charged in International $200 Million Credit Card Fraud Scam Crime Ring Invented 7,000 Fake Identities

  8. 1/9/09 2:14 PMResearchers Pinpoint Spontaneous Gene Mutations Responsible for 10 Percent of Non-Familial Cases of Schizophrenia Page 1 of 3http://cumc.columbia.edu/news/press_releases/gene-mutation-schizophrenia.html

    E-print Network

    -Familial Cases of Schizophrenia Page 1 of 3http://cumc.columbia.edu/news/press_releases/gene-mutation-schizophrenia Gene Mutations Responsible for 10 Percent of Non-Familial Cases of Schizophrenia NEW YORK (May 30, 2008) ­ Scans of the genome of patients with schizophrenia have revealed rare spontaneous copy number mutations

  9. Media Coverage, Journal Press Releases and Editorials Associated with Randomized and Observational Studies in High-Impact Medical Journals: A Cohort Study

    PubMed Central

    Wang, Michael T. M.; Bolland, Mark J.; Gamble, Greg; Grey, Andrew

    2015-01-01

    Background Publication of clinical research findings in prominent journals influences health beliefs and medical practice, in part by engendering news coverage. Randomized controlled trials (RCTs) should be most influential in guiding clinical practice. We determined whether study design of clinical research published in high-impact journals influences media coverage. Methods and Findings We compared the incidence and amount of media coverage of RCTs with that of observational studies published in the top 7 medical journals between 1 January 2013 and 31 March 2013. We specifically assessed media coverage of the most rigorous RCTs, those with >1000 participants that reported ‘hard’ outcomes. There was no difference between RCTs and observational studies in coverage by major newspapers or news agencies, or in total number of news stories generated (all P>0.63). Large RCTs reporting ‘hard’ outcomes did not generate more news coverage than small RCTs that reported surrogate outcomes and observational studies (all P>0.32). RCTs were more likely than observational studies to attract a journal editorial (70% vs 46%, P = 0.003), but less likely to be the subject of a journal press release (17% vs 50%, P<0.001). Large RCTs that reported ‘hard’ outcomes did not attract an editorial more frequently than other studies (61% vs 58%, P>0.99), nor were they more likely to be the subject of a journal press release (14% vs 38%, P = 0.14). Conclusions The design of clinical studies whose results are published in high-impact medical journals is not associated with the likelihood or amount of ensuing news coverage. PMID:26701758

  10. Nanotechnology Now -Press Release: "Sandia and UNM lead effort to destroy cancers: Boosting medicine with nanotechnology strengthens drug cocktail many times over" http://www.nanotech-now.com/news.cgi?story_id=42258[4/21/2011 11:23:41 AM

    E-print Network

    Brinker, C. Jeffrey

    Nanotechnology Now - Press Release: "Sandia and UNM lead effort to destroy cancers: Boosting > Press > Sandia and UNM lead effort to destroy cancers: Boosting medicine with nanotechnology strengthens and UNM lead effort to destroy cancers: Boosting medicine with nanotechnology strengthens drug cocktail

  11. Opening AP to All

    ERIC Educational Resources Information Center

    Gewertz, Catherine

    2008-01-01

    This article reports on a school's effort to open Advanced Placement (AP) to all by challenging its students to take the leap into AP courses. Samuel W. Wolfson High School, on the south side of Jacksonville, Florida, is one of 27 schools in five cities across the country that chose to participate in a College Board initiative called EXCELerator.…

  12. AP-Gate

    ERIC Educational Resources Information Center

    Whitman, Glenn

    2003-01-01

    In May 2001, students in the author's Advanced Placement (AP) United States History class were embroiled in a controversy surrounding the AP exam, in particular, having access to the exam's Document Based Question (DBQ) and free response portion prior to the test's administration. Prior to the exam, the College Board had provided a fifty-year time…

  13. Packard Building AP location plan AP Name AP location Ethernet MAC IP address

    E-print Network

    Levis, Philip

    Packard Building AP location plan #12;AP Name AP location Ethernet MAC IP address swanap61 Near Rm: Existing AP (Stanford Network) Proposed New AP location #12;Basement #12;1 st floor #12;2 nd floor #12;3 rd floor #12;

  14. APS Science 2006.

    SciTech Connect

    Gibson, J. M.; Fenner, R. B.; Long, G.; Borland, M.; Decker, G.

    2007-05-24

    In my five years as the Director of the Advanced Photon Source (APS), I have been fortunate to see major growth in the scientific impact from the APS. This year I am particularly enthusiastic about prospects for our longer-term future. Every scientific instrument must remain at the cutting edge to flourish. Our plans for the next generation of APS--an APS upgrade--got seriously in gear this year with strong encouragement from our users and sponsors. The most promising avenue that has emerged is the energy-recovery linac (ERL) (see article on page xx), for which we are beginning serious R&D. The ERL{at}APS would offer revolutionary performance, especially for x-ray imaging and ultrafast science, while not seriously disrupting the existing user base. I am very proud of our accelerator physics and engineering staff, who not only keep the current APS at the forefront, but were able to greatly impress our international Machine Advisory Committee with the quality of their work on the possible upgrade option (see page xx). As we prepare for long-term major upgrades, our plans to develop and optimize all the sectors at APS in the near future are advancing. Several new beamlines saw first light this year, including a dedicated powder diffraction beamline (11-BM), two instruments for inelastic x-ray scattering at sector 30, and the Center for Nanoscale Materials (CNM) Nanoprobe beamline at sector 26. Our partnership in the first x-ray free-electron laser (LCLS) to be built at Stanford contributes to revolutionary growth in ultrafast science (see page xx), and we are developing a pulse chirping scheme to get ps pulses at sector 7 of the APS within a year or so. In this report, you will find selected highlights of scientific research at the APS from calendar year 2006. The highlighted work covers diverse disciplines, from fundamental to applied science. In the article on page xx you can see the direct impact of APS research on technology. Several new products have emerged from work at the APS, to complement the tremendous output of work in basic science, which often has payoff in technology but over decades rather than years. Highlights in this report also reflect the relevance of APS work to Department of Energy missions, for example a route to more efficient fuel cells (page xx mr-88-073113) addresses the energy challenge, and natural approaches to cleaning up the environment.

  15. APS Science 2009.

    SciTech Connect

    Gibson, J. M; Mills, D. M.; Gerig, R.

    2010-05-01

    It is my pleasure to introduce the 2009 annual report of the Advanced Photon Source. This was a very good year for us. We operated with high reliability and availability, despite growing problems with obsolete systems, and our users produced a record output of publications. The number of user experiments increased by 14% from 2008 to more than 3600. We congratulate the recipients of the 2009 Nobel Prize in Chemistry-Venkatraman Ramakrishnan (Cambridge Institute for Medical Research), Thomas Steitz (Yale University), and Ada Yonath (Weizmann Institute) - who did a substantial amount of this work at APS beamlines. Thanks to the efforts of our users and staff, and the ongoing counsel of the APS Scientific Advisory Committee, we made major progress in advancing our planning for the upgrade of the APS (APS-U), producing a proposal that was positively reviewed. We hope to get formal approval in 2010 to begin the upgrade. With advocacy from our users and the support of our sponsor, the Office of Basic Energy Sciences in the Department of Energy (DOE) Office of Science, our operating budgets have grown to the level needed to more adequately staff our beamlines. We were also extremely fortunate to have received $7.9 M in American Recovery and Reinvestment Act ('stimulus') funding to acquire new detectors and improve several of our beamlines. The success of the new Linac Coherent Light Source at Stanford, the world's first x-ray free-electron laser, made us particularly proud since the undulators were designed and built by the APS. Among other highlights, we note that more than one-quarter of the 46 Energy Frontier Research Centers, funded competitively across the U.S. in 2009 by the DOE, included the Advanced Photon Source in their proposed work, which shows that synchrotron radiation, and the APS in particular, are central to energy research. While APS research covers everything from fundamental to applied science (reflected by the highlights in this report), the challenge of sustainable energy provides an opportunity for expanded involvement with industrial research. We were privileged to recruit several outstanding new leaders at the APS. Linda Young, from Argonne's Chemical Sciences Division, became the new Director of the X-ray Science Division (XSD). Chris Jacobsen (from Stony Brook University) has been added to Linda's team as an XSD Associate Division Director, joining George Srajer. Alexander (Sasha) Zholents (formerly of Berkeley Lab) became Director of the Accelerator Systems Division. Sasha is the inventor of the short-pulse x-ray scheme that we plan to implement in the APS-U to obtain very high average brightness, broadband, 1-ps x-ray pulses. Walter Lowe (formerly of Howard University) has taken a new position as senior advisor for outreach and development of the user community. Walter's role is to increase the diversity of the user community (with diversity read broadly to include users, institutions, and technical disciplines that are underrepresented at APS). Walter is also leading an effort to increase access for industrial users. I am confident that we have in place a great team to help our users and the APS take fullest advantage of the APS-U opportunity. In planning with users for the proposed APS-U, we focused on the need to study 'real materials under real conditions in real time' on spatial and temporal scales unavailable today. Only by studying materials as they are made-or as they perform-in difficult environments can we solve the grand challenge of higher-performance, sustainable materials for energy and health. The proposed APS-U will improve the brightness of penetrating x-rays produced by the APS over 100 times, and support our efforts in developing state-of-the-art instruments to address these challenges.

  16. Press release September 25, 2015

    E-print Network

    Goda, Keisuke

    of Economics) Coursera Visualizing Postwar Tokyo, Pt. 1 Shunya Yoshimi (Graduate School of Interdisciplinary Information Studies) edX Visualizing Postwar Tokyo, Pt. 2 Shunya Yoshimi edX 2015 academic year (in addition of Contemporary Japanese Architecture (tentative title) Kengo Kuma (Professor, Graduate School of Engineering) ed

  17. Wind Turbine Development: Press release

    SciTech Connect

    Not Available

    1994-05-09

    The US Department of Energy (DOE) has announced a new partnership with Zond Systems, Inc., of Tehachapi, California. The partnership is the firs to be announced under DOE`s new Value-Engineered Turbine (VET) project. The VET project is expected to lower the cost of manufacturing wind turbines and give the US wind industry a competitive boost.

  18. CSR Press Release Submitted by

    E-print Network

    and even levels of engagement vary from company to company, but businesses are taking sustainability and behavioural change delivery that has already enabled our clients to save millions of £'s and CO2 through and sustainability solutions for private and public sector organisations. We help our clients reduce their business

  19. PRESS RELEASE 2 June 2010

    E-print Network

    as part of our 'Plan A eco-plan'. We have found the term 'carbon neutral' highly effective standards-based solutions. Originating as the w orld's first national standards body, BSI has over 2® and CE marking toUK, European and international standards. BSI is a Notified Body for 15 New Approach EU

  20. Press Release | October 6, 2010

    E-print Network

    officially become the first university in Quebec to ban the sale of single-use bottled water on its campus initiated a "Think Global, Drink Local" campaign to raise awareness of the negative impacts of bottled water development intern, helped lead the "Think Global, Drink Local" campaign, successfully convincing her fellow

  1. University Art Museum PRESS RELEASE

    E-print Network

    Alexandrova, Ivana

    in our community. -more- Daniel Brody Game On / Game Over, 2015 Digital video, 9 minutes, 15 seconds Institute of History & Art, and The Hyde Collection in Glens Falls. It brings together local businesses

  2. Press Release April 1, 2015

    E-print Network

    School of Medicine; Associate Clinical Professor of Medicine and Pediatrics, IU School of Medicine. Two Development Center, Riley Hospital for Children; Associate Professor of Clinical Pediatrics, IU School, Chair of the Communication Studies Department, IU School of Liberal Arts. Using research from her book

  3. Press Release From MIST Council

    E-print Network

    Crowther, Paul

    "Space Weather" scientists welcome parliamentary report on science funding The parliamentary Innovation away its world lead in this area; however, it cannot prevent the loss of talented young scientists (its magnetosphere) and Earth's atmosphere. Scientists in the UK play a key role in understanding

  4. CSR Press Release Submitted by

    E-print Network

    Karmali - Bank of America Merrill Lynch, Allison Wood - Hunton & Williams, Annika Colston - Blue Source is designed for professionals working on environmental management issues as part of their companies' strategic Institutions, Corporate Representatives, Venture Capital Funds, Project Developers, Technology Providers

  5. PRESS RELEASE 22 December 2009

    E-print Network

    and evaluation of the carbon emission information throughout the product lifecycle of Hey Song Sarsaparilla. Hey in response to the government's policy for energy saving and carbon emission reduction, w e w ill continue certification contact your local BSI office. - ENDS - Notes to Editors For media information: Lucy Fulton Public

  6. PRESS RELEASE 26 May 2010

    E-print Network

    , archives, facilities, sales and exhibition as w ell as the UK Film Council, BSI and experts in the field documents agreed by experts in the field. As w ell as being w idely used w ithin the UK, they are used 50 global offices. The Group's key offerings are: The development and sale of private, national

  7. Press Release December 22, 2014

    E-print Network

    of plasma physics (AAPPS-DPP) Subramanyan Chandrasekhar Prize of Plasma Physics - Prof. Em. Setsuo Ichimaru of the University of Tokyo as the first Laureate of S. Chandrasekhar Prize of Plasma Physics, which is awarded

  8. CSR Press Release Submitted by

    E-print Network

    and services to customers. To meet customers' business intelligence needs, the Teradata Purpose-Built Platform-driven business intelligence. In addition to price and performance, customers can benefit from an operating

  9. PRESS RELEASE / PRESS RELEASE / PRESS RELEASE A new Advanced Master degree

    E-print Network

    Paragios, Nikos

    in Technology & Industry" The Ecole Centrale Paris will train very high-level buyers (Paris, January 12, 2010 will train students in the use of the most advanced techniques in purchasing and familiarise them Grandes Ecoles, is aimed at graduates (Bac + 5) from engineering schools and scientific universities

  10. 17 CFR 230.135e - Offshore press conferences, meetings with issuer representatives conducted offshore, and press...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...Exchanges 2 2011-04-01 2011-04-01 false Offshore press conferences, meetings with issuer representatives conducted offshore, and press-related materials released offshore. 230.135e Section 230.135e Commodity and...

  11. 17 CFR 230.135e - Offshore press conferences, meetings with issuer representatives conducted offshore, and press...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...Exchanges 2 2010-04-01 2010-04-01 false Offshore press conferences, meetings with issuer representatives conducted offshore, and press-related materials released offshore. 230.135e Section 230.135e Commodity and...

  12. Advancing beyond AP Courses

    ERIC Educational Resources Information Center

    Hammond, Bruce G.

    2009-01-01

    A quiet revolution is picking up steam in the nation's private secondary schools, with broad implications for college admissions and for teaching and learning on both sides of the transition from high school to college. About 50 of the nation's leading college-preparatory schools have opted out of the College Board's Advanced Placement (AP)…

  13. APS Science 2007.

    SciTech Connect

    Not Available

    2008-05-30

    This report provides research highlights from the Advanced Photon Source (APS). Although these highlights represent less than 10% of the published work from the APS in 2007, they give a flavor of the diversity and impact of user research at the facility. In the strategic planning the aim is to foster the growth of existing user communities and foresee new areas of research. This coming year finds the APS engaged in putting together, along with the users, a blueprint for the next five years, and making the case for a set of prioritized investments in beamlines, the accelerator, and infrastructure, each of which will be transformational in terms of scientific impact. As this is written plans are being formulated for an important user workshop on October 20-21, 2008, to prioritize strategic plans. The fruit from past investments can be seen in this report. Examples include the creation of a dedicated beamline for x-ray photon correlation spectroscopy at Sector 8, the evolution of dedicated high-energy x-ray scattering beamlines at sectors 1 and 11, a dedicated imaging beamline at Sector 32, and new beamlines for inelastic scattering and powder diffraction. A single-pulse facility has been built in collaboration with Sector 14 (BioCARS) and Phil Anfinrud at the National Institutes of Health, which will offer exceptionally high flux for single-pulse diffraction. The nanoprobe at Sector 26, built and operated jointly by the Argonne Center for Nanoscale Materials and the X-ray Operations and Research (XOR) section of the APS X-ray Science Division, has come on line to define the state of the art in nanoscience.

  14. Thermal Decomposition Characteristics of Orthorhombic Ammonium Perchlorate (o-AP) and an 0-AP/HTPB-Based Propellant

    SciTech Connect

    BEHRENS JR.,RICHARD; MINIER,LEANNA M.G.

    1999-10-25

    A study to characterize the low-temperature reactive processes for o-AP and an AP/HTPB-based propellant (class 1.3) is being conducted in the laboratory using the techniques of simultaneous thermogravimetric modulated beam mass spectrometry (STMBMS) and scanning electron microscopy (SEM). The results presented in this paper are a follow up of the previous work that showed the overall decomposition to be complex and controlled by both physical and chemical processes. The decomposition is characterized by the occurrence of one major event that consumes up to {approx}35% of the AP, depending upon particle size, and leaves behind a porous agglomerate of AP. The major gaseous products released during this event include H{sub 2}O, O{sub 2}, Cl{sub 2}, N{sub 2}O and HCl. The recent efforts provide further insight into the decomposition processes for o-AP. The temporal behaviors of the gas formation rates (GFRs) for the products indicate that the major decomposition event consists of three chemical channels. The first and third channels are affected by the pressure in the reaction cell and occur at the surface or in the gas phase above the surface of the AP particles. The second channel is not affected by pressure and accounts for the solid-phase reactions characteristic of o-AP. The third channel involves the interactions of the decomposition products with the surface of the AP. SEM images of partially decomposed o-AP provide insight to how the morphology changes as the decomposition progresses. A conceptual model has been developed, based upon the STMBMS and SEM results, that provides a basic description of the processes. The thermal decomposition characteristics of the propellant are evaluated from the identities of the products and the temporal behaviors of their GFRs. First, the volatile components in the propellant evolve from the propellant as it is heated. Second, the hot AP (and HClO{sub 4}) at the AP-binder interface oxidize the binder through reactions that preferentially strip the hydrogen from the binder and yield HCl and H{sub 2}O with some oxidation of the carbon from the binder. Third, the o-AP in the propellant decomposes in the same manner as in neat o-AP. Finally, AP-derived gaseous products interact with other ingredients in the propellant.

  15. Please cite this article in press as: Gingerich, A.J. et al., Evaluation of the interactive effects of air exposure duration and water temperature on the condition and survival of angled and released fish, Fish. Res. (2007), doi:10.1016/j.fishres.2007.06.

    E-print Network

    Suski, Cory David

    2007-01-01

    depressed ventilation rates relative to fish exposed to minimal air exposure and the lowest temperature of air exposure duration and water temperature on the condition and survival of angled and released fish, Fish. Res. (2007), doi:10.1016/j.fishres.2007.06.002 ARTICLE IN PRESS+Model FISH-2352; No.of Pages10

  16. AP-42 REVISION: COKE OVENS

    EPA Science Inventory

    The document "Compilation of Air Pollutant Emission Factors" (AP-42) has been published by the U. S. Environmental Protection Agency (EPA) since 1972. Supplements to AP-42 have been routinely published to add new emission source categories and to update existing emission factor...

  17. APS controls overview

    SciTech Connect

    1996-02-01

    The APS accelerator control system described in this report is a distributed system consisting of operator interfaces, a network, and interfaces to hardware. The operator interface is a UNIX-based workstation with an X-windows graphical user interface. The workstation may be located at any point on the facility network and maintain full functionality. The user has the ability to generate and alter control displays and to access the alarm handler, the archiver, interactive control programs, custom code, and other tools. The TCP/EP networking protocol has been selected as the underlying protocol for the control system network. TCP/EP is a commercial standard and readily available from network hardware vendors. Its implementation is independent of the particular network medium selected to implement the controls network. In the development environment copper Ethernet is the network medium; however, in the actual implementation a fiber-based system using hub technology will be utilized. The function of the network is to provide a generalized communication path between the host computers, operator workstations, input/output crates, and other hardware that comprise the control system.

  18. In situ gel-forming AP-57 peptide delivery system for cutaneous wound healing.

    PubMed

    Li, Xiaoling; Fan, Rangrang; Tong, Aiping; Yang, Meijia; Deng, Jiaojiao; Zhou, Liangxue; Zhang, Xiaoning; Guo, Gang

    2015-11-10

    In situ gel-forming system as local drug delivery system in dermal traumas has generated a great interest. Accumulating evidence shows that antimicrobial peptides play pivotal roles in the process of wound healing. Here in this study, to explore the potential application of antimicrobial peptide in wound healing, biodegradable poly(l-lactic acid)-Pluronic L35-poly(l-lactic acid) (PLLA-L35-PLLA) was developed at first. Then based on this polymer, an injectable in situ gel-forming system composed of human antimicrobial peptides 57 (AP-57) loaded nanoparticles and thermosensitive hydrogel was prepared and applied for cutaneous wound healing. AP-57 peptides were enclosed with biocompatible nanoparticles (AP-57-NPs) with high drug loading and encapsulation efficiency. AP-57-NPs were further encapsulated in a thermosensitive hydrogel (AP-57-NPs-H) to facilitate its application in cutaneous wound repair. As a result, AP-57-NPs-H released AP-57 in an extended period and exhibited quite low cytotoxicity and high anti-oxidant activity in vitro. Moreover, AP-57-NPs-H was free-flowing liquid at room temperature, and can form non-flowing gel without any crosslink agent upon applied on the wounds. In vivo wound healing assay using full-thickness dermal defect model of SD rats indicated that AP-57-NPs-H could significantly promote wound healing. At day 14 after operation, AP-57-NPs-H treated group showed nearly complete wound closure of 96.78±3.12%, whereas NS, NPs-H and AP-57-NPs group recovered by about 68.78±4.93%, 81.96±3.26% and 87.80±4.62%, respectively. Histopathological examination suggested that AP-57-NPs-H could promote cutaneous wound healing through enhancing granulation tissue formation, increasing collagen deposition and promoting angiogenesis in the wound tissue. Therefore, AP-57-NPs-H might have potential application in wound healing. PMID:26363112

  19. Low Earth orbit assessment of proton anisotropy using AP8 and AP9 trapped proton models.

    PubMed

    Badavi, Francis F; Walker, Steven A; Santos Koos, Lindsey M

    2015-04-01

    The completion of the International Space Station (ISS) in 2011 has provided the space research community with an ideal evaluation and testing facility for future long duration human activities in space. Ionized and secondary neutral particles radiation measurements inside ISS form the ideal tool for validation of radiation environmental models, nuclear reaction cross sections and transport codes. Studies using thermo-luminescent detectors (TLD), tissue equivalent proportional counter (TPEC), and computer aided design (CAD) models of early ISS configurations confirmed that, as input, computational dosimetry at low Earth orbit (LEO) requires an environmental model with directional (anisotropic) capability to properly describe the exposure of trapped protons within ISS. At LEO, ISS encounters exposure from trapped electrons, protons and geomagnetically attenuated galactic cosmic rays (GCR). For short duration studies at LEO, one can ignore trapped electrons and ever present GCR exposure contributions during quiet times. However, within the trapped proton field, a challenge arises from properly estimating the amount of proton exposure acquired. There exist a number of models to define the intensity of trapped particles. Among the established trapped models are the historic AE8/AP8, dating back to the 1980s and the recently released AE9/AP9/SPM. Since at LEO electrons have minimal exposure contribution to ISS, this work ignores the AE8 and AE9 components of the models and couples a measurement derived anisotropic trapped proton formalism to omnidirectional output from the AP8 and AP9 models, allowing the assessment of the differences between the two proton models. The assessment is done at a target point within the ISS-11A configuration (circa 2003) crew quarter (CQ) of Russian Zvezda service module (SM), during its ascending and descending nodes passes through the south Atlantic anomaly (SAA). The anisotropic formalism incorporates the contributions of proton narrow pitch angle (PA) and east-west (EW) effects. Within SAA, the EW anisotropy results in different level of exposure to each side of the ISS Zvezda SM, allowing angular evaluation of the anisotropic proton spectrum. While the combined magnitude of PA and EW effects at LEO depends on a multitude of factors such as trapped proton energy, orientation and altitude of the spacecraft along the velocity vector, this paper draws quantitative conclusions on the combined anisotropic magnitude differences within ISS SM target point between AP8 and AP9 models. PMID:26177846

  20. AP Human Geography and Success on the AP Test

    ERIC Educational Resources Information Center

    Roncone, John; Newhalfen, Nate

    2013-01-01

    Classroom projects that explore culture and globalization enhance the curriculum and help students see how geography directly connects to their lives. These authors contend that a project-based approach can supplement the teaching of an AP Human Geography course, and visualize this course as an essential tool for students to truly understand how…

  1. AP Geography, Environmental Science Thrive

    ERIC Educational Resources Information Center

    Robelen, Erik W.

    2012-01-01

    Geography may not be particularly known as a hot topic among today's students--even some advocates suggest it suffers from an image problem--but by at least one measure, the subject is starting to come into its own. Across more than 30 topics covered in the Advanced Placement (AP) program, participation in geography is rising faster than any…

  2. Please cite this article in press as: A.P. Mller, et al., High frequency of albinism and tumours in free-living birds around Chernobyl, Mutat. Res.: Genet. Toxicol. Environ. Mutagen. (2013), http://dx.doi.org/10.1016/j.mrgentox.2013.04.019

    E-print Network

    Mousseau, Timothy A.

    2013-01-01

    in free-living birds around Chernobyl, Mutat. Res.: Genet. Toxicol. Environ. Mutagen. (2013), http.elsevier.com/locate/mutres High frequency of albinism and tumours in free-living birds around Chernobyl A.P. Møllera, , A Keywords: Albinism Chernobyl Population decline Radiation Tumours a b s t r a c t The effects

  3. University of Toronto; Faculty of Applied Science and Engineering. Course Outline: Financial Management for Engineers. APS1016H. Fall 2013

    E-print Network

    Toronto, University of

    : Financial Management for Engineers. APS1016H. Fall 2013 Entrepreneurship, Leadership, Innovation 1016: Financial Management for Engineers Week Subject Class activity 1 Sept. 9th 2013 Introductions PPT, Distressed, and Complex Businesses (FT Press, ISBN-13: 9780137126897) Valuation: Measuring and Managing

  4. Letting The NASA Press Engine Work For You

    NASA Technical Reports Server (NTRS)

    Weaver, Kimberly

    2006-01-01

    You have an amazing result based on NASA data or a NASA Mission; you have written your seminal paper and submitted it to your favorite journal. You believe it has press potential and maybe you've even gotten help from your PR folks in writing a press release. Now you would really like NASA to issue this as a press release. But how do you do that? This presentation will illustrate the steps required to engage NASA in helping promote your story. What are NASA's requirements for newsworthiness? Should your news be released as a web feature story or in the local media? Does your news rise to the level of a full-blown press conference or will it be a media teleconference? How do you obtain approval for a NASA press event? Once your result is scheduled to be issued as a press release, how can you improve your chances of getting the best possible coverage for your story? I will discuss the NASA press process and suggest how to consider factors like timing, working with your collaborating institutions in an efficient way, and not letting the cat out of the bag until the press event.

  5. Preparing Students for the AP Psychology Exam

    ERIC Educational Resources Information Center

    Whitlock, Kristin

    2013-01-01

    The Advanced Placement Psychology exam is one of the fastest growing exams offered by the College Board. The average percent of change in the number of students taking this exam over the past five years is 12.4%. With 238,962 students taking the exam in 2013, the AP Psychology exam is the sixth largest exam, surpassing AP Biology and AP World…

  6. ASSESSING CHEMICAL RELEASES AND WORKER EXPOSURES FROM A FILTERPRESS

    EPA Science Inventory

    Chemical releases and worker exposures associated with the filtration of an industrial wastewater sludge were characterized. The filter was a recessed chamber filter press with an open filtrate discharge system. Chemical releases and worker exposures for a selected chemical were ...

  7. Sherwood/APS 2006 Conference

    SciTech Connect

    James F. Drake

    2009-07-28

    The International Sherwood Theory Meeting is a yearly meeting that focuses on the theory of magnetically confined fusion plasmas. There are many topics of common interest in fusion plasma systems and space and astrophysical plasmas. These common topics include such key topics as magnetic reconnection, the dynamo, turbulence and transport and particle heating and acceleration. One of the major participants of the April APS meeting is the APS Division of Astrophysics (DAP). The goal of having the Sherwood Meeting jointly with the April meeting was to promote discussion of topics of common interest in fusion and space and astrophysics. Scientists from the DAP, the Division of Plasma Physics (DPP), the Topical Group on Plasma Astrophysics (GPAP) and Sherwood worked together closely to produce a joint program that addressed areas of common interest. Four sessions of invited talks were sponsored jointly by the DAP, DPP and GPAP on laboratory experiments related to astrophysics. Plasma scientists working in theory and computation play a key role in connecting these laboratory experiments to the very disparate conditions found in fusion and astrophysical systems. Thus, the attendees of the Sherwood Theory meeting were critical to facilitating this effort at cross-disciplinary communication. Noteworthy were the selection of two of the prestigious plenary talks at the joint meeting on plasma topics - one related to the gyrokinetic modeling of turbulence and the other related to the structure of collisionless shocks. It is rare to see even a single plenary talk on plasma physics at the APS April Meeting. There were additional costs associated with hosting a joint meeting. The Office of Fusion Energy Sciences contributed $3000 in partial support of this meeting. This funding covered part of the costs of the poster boards and A. V. equipment that was used in the presentation of nearly 200 scientific papers related to magnetically confined fusion plasmas. The APS waived its indirect costs on this funding as part of their effort to support this joint meeting.

  8. The APS control system network

    SciTech Connect

    Sidorowicz, K.V.; McDowell, W.P.

    1995-12-31

    The APS accelerator control system is a distributed system consisting of operator interfaces, a network, and computer-controlled interfaces to hardware. This implementation of a control system has come to be called the {open_quotes}Standard Model.{close_quotes} The operator interface is a UNDC-based workstation with an X-windows graphical user interface. The workstation may be located at any point on the facility network and maintain full functionality. The function of the network is to provide a generalized communication path between the host computers, operator workstations, input/output crates, and other hardware that comprise the control system. The crate or input/output controller (IOC) provides direct control and input/output interfaces for each accelerator subsystem. The network is an integral part of all modem control systems and network performance will determine many characteristics of a control system. This paper will describe the overall APS network and examine the APS control system network in detail. Metrics are provided on the performance of the system under various conditions.

  9. Dynamics of intracellular clathrin/AP1 and clathrin/AP3 containing carriers

    PubMed Central

    Kural, Comert; Tacheva-Grigorova, Silvia K.; Boulant, Steeve; Cocucci, Emanuele; Baust, Thorsten; Duarte, Delfim; Kirchhausen, Tom

    2012-01-01

    Clathrin/AP1 and clathrin/AP3 coated vesicular carriers originate from endosomes and the TGN. We report here the real-time visualization of these structures in living cells reliably tracked by using rapid, three-dimensional imaging with a spinning-disk confocal microscope. We imaged relatively sparse, diffraction-limited, fluorescent objects containing chimeric fluorescent protein (clathrin light chain, ? adaptor subunits or dynamin2) with a spatial precision of up to ~ 30 nm and a temporal resolution of ~ 1 sec. The dynamic characteristics of the intracellular clathrin/AP1 and clathrin/AP3 carriers are similar to those of endocytic clathrin/AP2 pits and vesicles; the clathrin/AP1 coats are, on average, slightly shorter-lived than their AP2 and AP3 counterparts. We confirmed that while dynamin2 is recruited as a burst to clathrin/AP2 pits immediately before their budding from the plasma membrane, we found no evidence supporting a similar association of dynamin2 with clathrin/AP1 or clathrin/AP3 carriers at any stage during their lifetime. We found no effects of chemical inhibitors of dynamin function or the K44A dominant negative mutant of dynamin on AP1 and AP3 dynamics. This observation suggests that an alternative budding mechanism, yet to be discovered, is responsible for the scission step of clathrin/AP1 and clathrin/AP3 carriers. PMID:23103167

  10. recent press releases MIT scientists theorize

    E-print Network

    Yanik, Mehmet Fatih

    in experiments that require a large number of animals, such as testing the effects of many different drugs, 2010 Students develop a low- cost portable ventilator July 15, 2010 MIT researchers create fibers. -- One of the most commonly studied laboratory animals is the zebrafish -- a tiny fish with transparent

  11. PRESS RELEASE Paris, July 16, 2015

    E-print Network

    exchanges between the chloroplast and the mitochondrion, the cellular organelle responsible for respiration by the action of light, is attached to the mitochondrion, the site of cell respiration. The two cellular.tilly@cea.fr Phaeodactylum tricornutum (diatom) Chloroplast (photosynthesis) Mitochondrion (respiration) #12;

  12. Press Release EU, November 27th

    E-print Network

    of the Internet of Things, as well as other new and innovative applications, will see tens of billions communications system. METIS is a consortium of 29 partners spanning telecommunications manufacturers, network

  13. press release Edward Elgar Publishing Inc.

    E-print Network

    Nagurney, Anna

    of supply chains (as fluid models and in an network economic framework) and new applications of agent approaches to economic networks are developed in the context of supply chain and distribution networks in computational economics and finance, operations research, management science, applied mathematics and computer

  14. PRESS RELEASE 18th Wild Chimpanzee Foundation

    E-print Network

    and their habitat, the tropical rainforest, throughout tropical Africa. The philosophy of the WCF is threefold this competition we were looking for programmes which are innovative, sustainable and create real impact ­ and we of entrepreneurship, sustainability, and impact. The winners were selected by a panel of international judges

  15. CECAD, University of Cologne Press release

    E-print Network

    Hartmann, Robert

    2015 (Epub) de Boor, S.*, Knyphausen, P.*, Kuhlmann, N., Wroblowski, S., Brenig, J., Nolte, H., Krüger-acetylation. Proc. Natl. Acad. Sci. U. S. A.] 12(28):E3679-88. doi: 10.1073/pnas.1505995112. Epub 2015 Jun 29

  16. Report Nation March 2015 Press Release

    Cancer.gov

    For the first time, researchers have used national data to determine the incidence of the four major molecular subtypes of breast cancer by age, race/ethnicity, poverty level, and several other factors. The report showed continuing declines in cancer dea

  17. European Molecular Biology Organization PRESS RELEASE

    E-print Network

    Laux, Thomas

    by serving on advisory editorial boards of the organizations four scientific journals, mentoring young, Switzerland Ulrike Kutay, Switzerland Karim Labib, United Kingdom Ernest Laue, United Kingdom Thomas Laux, United States Michael R. Green, United States Thomas M. Jessell, United States Robert Martienssen, United

  18. About Global Forest Watch Press Release

    E-print Network

    in Indonesia, resulting in a doubling of the country's deforestation rates in the late 1990s, according. "Deforestation on this scale, at this speed, is unprecedented," said Emily Matthews, co-author of the report concludes that the doubling of deforestation rates in Indonesia is largely the result of a corrupt political

  19. [White House Press Releases on Drug Abuse.

    ERIC Educational Resources Information Center

    Executive Office of the President, Washington, DC.

    This collection of documents is concerned, specifically, with the problem of drug abuse in the U. S. and the coordinated attack planned by the President's proposed Special Action Office for Drug Abuse Prevention. The office would not be concerned, directly, with problems of reducing drug supply or with the law enforcement aspects of abuse control,…

  20. Press Release For the 1st

    E-print Network

    Chan, Hue Sun

    of the program a Canadian scientist is honoured with this award. Professor Eugenia Kumacheva, born in Russia in Canada, for the design and development of new materials with many applications including targeted drug

  1. PRESS RELEASE CONTACT: Jennifer Lewis, Managing Director

    E-print Network

    Rock, Chris

    (ICIAM) in Beijing, China, August 10 -14, 2015. Allen is the Paul Whitfield Horn Professor of Mathematics and stochastic models with a Paul Whitfield Horn Professorship. Since 1999, Allen has served as an adjunct

  2. AP reclamation and reuse in RSRM propellant

    NASA Technical Reports Server (NTRS)

    Miks, Kathryn F.; Harris, Stacey A.

    1995-01-01

    A solid propellant ingredient reclamation pilot plant has been evaluated at the Strategic Operations of Thiokol Corporation, located in Brigham City, Utah. The plant produces AP wet cake (95 percent AP, 5 percent water) for recycling at AP vendors. AP has been obtained from two standard propellant binder systems (PBAN and HTPB). Analytical work conducted at Thiokol indicates that the vendor-recrystallized AP meets Space Shuttle propellant specification requirements. Thiokol has processed 1-, 5-, and 600-gallon propellant mixes with the recrystallized AP. Processing, cast, cure, ballistic, mechanical, and safety properties have been evaluated. Phillips Laboratory static-test-fired 70-pound and 800-pound BATES motors. The data indicate that propellant processed with reclaimed AP has nominal properties.

  3. Press Start

    NASA Astrophysics Data System (ADS)

    Harteveld, Casper

    This level sets the stage for the design philosophy called “Triadic Game Design” (TGD). This design philosophy can be summarized with the following sentence: it takes two to tango, but it takes three to design a meaningful game or a game with a purpose. Before the philosophy is further explained, this level will first delve into what is meant by a meaningful game or a game with a purpose. Many terms and definitions have seen the light and in this book I will specifically orient at digital games that aim to have an effect beyond the context of the game itself. Subsequently, a historical overview is given of the usage of games with a serious purpose which starts from the moment we human beings started to walk on our feet till our contemporary society. It turns out that we have been using games for all kinds of non-entertainment purposes for already quite a long time. With this introductory material in the back of our minds, I will explain the concept of TGD by means of a puzzle. After that, the protagonist of this book, the game Levee Patroller, is introduced. Based on the development of this game, the idea of TGD, which stresses to balance three different worlds, the worlds of Reality, Meaning, and Play, came into being. Interested? Then I suggest to quickly “press start!”

  4. Agenda Building Role of News Releases in Corporate Takeovers.

    ERIC Educational Resources Information Center

    Ohl, Coral M.; And Others

    1995-01-01

    Examines how particular characteristics of two companies' press releases, generated during a hostile takeover attempt, influenced the media's news decisions. Finds that press releases from Prime Computer were associated with newspaper articles that were longer, more favorable to its point of view, and contained the same lead message points as…

  5. AP-1A controls secretory granule biogenesis and trafficking of membrane secretory granule proteins

    PubMed Central

    Bonnemaison, Mathilde; Bäck, Nils; Lin, Yimo; Bonifacino, Juan S.; Mains, Richard; Eipper, Betty

    2014-01-01

    The adaptor protein 1A complex (AP-1A) transports cargo between the trans-Golgi network (TGN) and endosomes. In professional secretory cells, AP-1A also retrieves material from immature secretory granules (SGs). The role of AP-1A in SG biogenesis was explored using AtT-20 corticotrope tumor cells expressing reduced levels of the AP-1A ?1A subunit. A two-fold reduction in ?1A resulted in a decrease in TGN cisternae and immature SGs and the appearance of regulated secretory pathway components in non-condensing SGs. Although basal secretion of endogenous SG proteins was unaffected, secretagogue-stimulated release was halved. The reduced ?1A levels interfered with the normal trafficking of carboxypeptidase D (CPD) and peptidylglycine ?-amidating monooxygenase-1 (PAM-1), integral membrane enzymes that enter immature SGs. The non-condensing SGs contained POMC products and PAM-1, but not CPD. Based on metabolic labeling and secretion experiments, the cleavage of newly synthesized PAM-1 into PHM was unaltered, but PHM basal secretion was increased in sh-?1A PAM-1 cells. Despite lacking a canonical AP-1A binding motif, yeast two-hybrid studies demonstrated an interaction between the PAM-1 cytosolic domain and AP-1A. Co-immunoprecipitation experiments with PAM-1 mutants revealed an influence of the luminal domains of PAM-1 on this interaction. Thus, AP-1A is crucial for normal SG biogenesis, function and composition. PMID:25040637

  6. Press Release For Immediate Release Seattle, USA. June 12, 2008

    E-print Network

    of increased competition for logs in the domestic market because the availability of Russian logs is dwindling implemented. The Russian government has assisted its forest industry by shutting of foreign competition

  7. Press release For Immediate Release Seattle, USA. May 21, 2008

    E-print Network

    and wood-based panel manufacturers eased early in the year resulting in more than 10% lower conifer fiber. These events resulted in the average global conifer wood price reaching a new all-time-high of US$109.67/odmt. The average non-conifer wood fiber costs were also up in the 1Q, reaching a record-high of US$106.11/odmt

  8. Press Release For Immediate Release Contact: Jennifer Morcone, CDC

    E-print Network

    they share the water with everyone else in the pool who may spread illness, including kids in diapers in diapers are advised to keep their children out of the pool if they have diarrhea. CDC also recommends swimming and washing their hands after visiting the restroom or changing diapers. According to CDC's most

  9. PRESS RELEASE 25 11 2015 -For immediate release

    E-print Network

    Ulidowski, Irek

    FUNDING FOR THE ENERGY RESEARCH ACCELERATOR £60m of Government funding for the Energy Research and universities. Research will transform UK expertise in energy storage, thermal energy and energy efficiency. Six Midlands Innovation Universities and the British Geological Survey welcome £180m Midlands energy

  10. Press release For Immediate Release Seattle, USA. June 6, 2008

    E-print Network

    wood pellets has gone up substantially the past few years as reported in the latest issue of the Wood Resource Quarterly. Global trade of wood pellets reached over three million tons in 2007. One of the most. Trade of wood pellets, which account for a large share of biomass trade, reached a record of over three

  11. ARTICLE IN PRESS Neurocomputing ( )

    E-print Network

    Breakspear, Michael

    ARTICLE IN PRESS Neurocomputing ( ) ­ www.elsevier.com/locate/neucom Modulation of excitatory-2312(02)00740-3 #12;2 M. Breakspear et al. / Neurocomputing ( ) ­ ARTICLE IN PRESS of a perceived object [11

  12. ARTICLE IN PRESS Neurocomputing ( )

    E-print Network

    Koch, Christof

    ARTICLE IN PRESS Neurocomputing ( ) ­ www.elsevier.com/locate/neucom Predictions of a model / Neurocomputing ( ) ­ ARTICLE IN PRESS be generated by a pooled response from several "simple cells". This idea

  13. Doppler Imaging of Ap Stars

    E-print Network

    R. Kuschnig

    1998-05-06

    Doppler imaging, a technique which inverts spectral line profile variations of an Ap star into a two-dimensional abundance maps, provides new observational constraints on diffusion mechanism in the presence of a global magnetic field. A programme is presented here with the aim to obtain abundance distributions of at least five elements on each star, in order to study how different diffusion processes act under influence of a stellar magnetic field. The importance of this multi-element approach is demonstrated, by presenting the abundance maps of helium, magnesium, silicon, chromium and iron for the magnetic B9pSi star CU Virginis.

  14. Tank 241-AP-106, Grab samples, 6AP-98-1, 6AP-98-2 and 6AP-98-3 Analytical results for the final report

    SciTech Connect

    FULLER, R.K.

    1999-02-23

    This document is the final report for tank 241-AP-106 grab samples. Three grab samples 6AP-98-1, 6AP-98-2 and 6AP-98-3 were taken from riser 1 of tank 241-AP-106 on May 28, 1998 and received by the 222-S Laboratory on May 28, 1998. Analyses were performed in accordance with the ''Compatability Grab Sampling and Analysis Plan'' (TSAP) (Sasaki, 1998) and the ''Data Quality Objectives for Tank Farms Waste Compatability Program (DQO). The analytical results are presented in the data summary report. No notification limits were exceeded. The request for sample analysis received for AP-106 indicated that the samples were polychlorinated biphenyl (PCB) suspects. The results of this analysis indicated that no PCBs were present at the Toxic Substance Control Act (TSCA) regulated limit of 50 ppm. The results and raw data for the PCB analysis are included in this document.

  15. ELECTROCHEMICAL CORROSION TESTING OF TANKS 241-AN-102 & 241-AP-107 & 241-AP-108 IN SUPPORT OF ULTRASONIC TESTING

    SciTech Connect

    WYRWAS RB; DUNCAN JB

    2008-11-20

    This report presents the results of the corrosion rates that were measured using electrochemical methods for tanks 241-AN-102 (AN-102), 241-AP-107 (AP 107), and 241-AP-108 (AP-108) performed under test plant RPP-PLAN-38215. The steel used as materials of construction for AN and AP tank farms was A537 Class 1. Test coupons of A537 Class 1 carbon steel were used for corrosion testing in the AN-107, AP-107, and AP-108 tank waste. Supernate will be tested from AN-102, AP-107, and Ap-108. Saltcake testing was performed on AP-108 only.

  16. The Global University Press

    ERIC Educational Resources Information Center

    Dougherty, Peter J.

    2012-01-01

    The modern world's understanding of American university press has long been shaped by university-press books. American university-press books are good international advertisements for the universities whose logos grace their spines. The growth of transnational scholarship and the expansion of digital communications networks are converging in ways…

  17. APS high heat load monochromator

    SciTech Connect

    Lee, W.K.; Mills, D.

    1993-02-01

    This document contains the design specifications of the APS high heat load (HHL) monochromator and associated accessories as of February 1993. It should be noted that work is continuing on many parts of the monochromator including the mechanical design, crystal cooling designs, etc. Where appropriate, we have tried to add supporting documentation, references to published papers, and calculations from which we based our decisions. The underlying philosophy behind performance specifications of this monochromator was to fabricate a device that would be useful to as many APS users as possible, that is, the design should be as generic as possible. In other words, we believe that this design will be capable of operating on both bending magnet and ID beamlines (with the appropriate changes to the cooling and crystals) with both flat and inclined crystal geometries and with a variety of coolants. It was strongly felt that this monochromator should have good energy scanning capabilities over the classical energy range of about 4 to 20 keywith Si (111) crystals. For this reason, a design incorporating one rotation stage to drive both the first and second crystals was considered most promising. Separate rotary stages for the first and second crystals can sometimes provide more flexibility in their capacities to carry heavy loads (for heavily cooled first crystals or sagittal benders of second crystals), but their tuning capabilities were considered inferior to the single axis approach.

  18. Coaching Strategies for AP: Building a Successful AP European History Program

    ERIC Educational Resources Information Center

    Fornaciari, Jim

    2014-01-01

    The October 2013 special issue of "Social Education" dealt with almost all AP social studies subjects, but omitted AP European History. This is one of the most fascinating AP subjects for students and teachers alike. In this article, the author shares his experiences since hewas given the responsibility of building his school's…

  19. APS: Lighting up the future

    SciTech Connect

    Potent, V.J.

    1993-09-01

    Work on the Advanced Photon Source (APS) at Argonne National Laboratory (ANL) involves the construction and supporting research and development for a national user facility for synchrotron radiation research in the x-ray region. The facility, when operational in 1997, will provide super-intense x-ray beams for many areas of basic research and will serve the entire US x-ray research community of several thousand users. This paper describes the pertinent features of the design, construction and planned operation of the facility; and the impact quality has had in these areas. In addition, the introduction of several quality management techniques such as total quality management, reliability/availability planning, and user interface are discussed concerning their status and success.

  20. AP-42 ADDITIONS AND REVISIONS - WILDLAND FIRES

    EPA Science Inventory

    This project is aimed at consolidating, selecting, and disseminating the most appropriate data and methods for estimating air emissions from wildfires and prescribed burns. The product will replace a current section of AP-42, but may not take the precise form of an AP-42 secti...

  1. APS-DPP Education and Outreach

    NASA Astrophysics Data System (ADS)

    Correll, Donald

    1998-11-01

    Through its membership and their respectful institutions, the APS-DPP continues to be recognized for its education and outreach efforts. Each year starting with the 1988 DPP annual meeting, DPP and the APS Office of Education have jointly sponsored a "Science Teachers' Day." Beginning in 1994, a companion "Plasma Physics Expo" has been held during the same week of the November meeting. Both events continue to receive uniformly enthusiastic responses from teachers and students who participate. These two events are not only supported financially by APS and APS-DPP but also by APS-DPP member contributions and by contributions of the major plasma physics and fusion research institutions. Recently, the DPP Interdivisional and Public Affairs Committee was re-named the DPP Science Education Committee (see DPP Newsletter, Spring 1998) to reflect the importance that the DPP puts on education and outreach. Nevertheless, as Andrew Sessler, APS President, said in the Education Outreach special insert of the January APS News "We have many education and outreach activities in the areas of K -12 education . . . but very few APS members are aware of what we are doing . . . ." This paper is an attempt to communicate to the DPP members who have not participated in DPP's education and outreach activities a summary of what is being accomplished in this area, what is being planned for the future, and how does one participate in these activities.

  2. Bachmann, K. T., Schou, J., and Brown, T. M. 1993, Ap. J., submitted. Brown, T. M. 1980, in Solar Instrumentation: What's Next?, ed. R. Dunn, (Sunspot, NM

    E-print Network

    Schou, Jesper

    and Magnetohydrodynamic Problems in the Sun and Stars, ed. Y. Osaki (Tokyo: University of Tokyo Press), p. 117­143. 105­400. Jefferies, S. M., Duvall, T. L., Harvey, J. W., Osaki, Y., and Pomerantz, M. A. 1991, Ap. J., 377, 330

  3. Incorporating Ninth-Grade PSAT/NMSQT® Scores into AP Potential™ Predictions for AP® European History and AP World History. Statistical Report 2014-1

    ERIC Educational Resources Information Center

    Zhang, Xiuyuan; Patel, Priyank; Ewing, Maureen

    2015-01-01

    Historically, AP Potential™ correlations and expectancy tables have been based on 10th-and 11th-grade PSAT/NMSQT® examinees and 11th-and 12th-grade AP® examinees for all subjects (Zhang, Patel, & Ewing,2014; Ewing, Camara, & Millsap, 2006; Camara & Millsap, 1998). However, a large number of students take AP European History and AP

  4. 55. QUARRY TILE CUTTERS, SECOND FLOOR, NORTH WING. WORKERS PRESSED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    55. QUARRY TILE CUTTERS, SECOND FLOOR, NORTH WING. WORKERS PRESSED THE CUTTERS INTO SLABS OF CLAY, LIFTED THEM ONTO DRYING BOARDS AND PRESSED THE PLUNGERS TO RELEASE THE CUT TILES. REPRODUCTIONS CUTTERS ARE NOT USED IN PRODUCTION. WOODEN FORMS FOR PRODUCING CLAY SLABS WITH ROLLING PINS REST AGAINST THE WALL. - Moravian Pottery & Tile Works, Southwest side of State Route 313 (Swamp Road), Northwest of East Court Street, Doylestown, Bucks County, PA

  5. 77 FR 24480 - Application for New Awards; Advanced Placement (AP) Test Fee Program-Reopening the AP Test Fee...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-24

    ...Reopening the AP Test Fee Fiscal Year 2012 Competition AGENCY: Office of Elementary and Secondary...reopening the AP Test Fee fiscal year 2012 competition...AP Test Fee fiscal year (FY) 2012 competition (February 15 notice). That...

  6. Smithsonian Institution Scholarly Press

    E-print Network

    Iliffe, Thomas M.

    Smithsonian Institution Scholarly Press Proceedings of the Smithsonian Marine Science Symposium. Kornicker, Department of Invertebrate Zoology, National Museum of Natural History, Smithsonian Institu- tion

  7. Regulation of atriopeptin release from the isolated rat heart

    SciTech Connect

    Currie, M.G.; Newman, W.H.

    1986-03-05

    Recent studies have demonstrated that the mammalian atria possess an endocrine function which appears to play a role in the regulation of systemic arterial pressure, fluid balance, and electrolyte homeostasis. They have begun to study the regulation of atriopeptin (atrial natriuretic factor) release into the coronary effluent of the isolated perfused rat heart. Characterization by high pressure liquid chromatography of the form of the hormone released indicates that the predominant form is the active low MW circulating hormone not the pro-hormone. The release of immunoreactive atriopeptin (iAP) was stimulated by infusion of norepinephrine (1 ..mu..M) or epinephrine (1 ..mu..M) 3.0 and 2.6-fold, respectively. The ..beta..-adrenergic agonist isoproterenol and the ..cap alpha..-2 adrenergic agonist BHT-920 lacked effects on iAP release. On the other hand, the ..cap alpha..-1 adrenergic agonist phenylephrine caused a dose-dependent increase in release of iAP. Release of iAP stimulated by phenylephrine was inhibited by the ..cap alpha.. antagonist phentolamine. Further, iAP release was stimulated 4.2-fold by phorbol ester (1 ..mu..M) but was not affected by 4-..beta.. phorbol (1 ..mu..M). From these collective data they conclude that the release of atriopeptin is stimulated by ..cap alpha..-1 receptor activation and that protein kinase C participates in the regulation of secretion. The data suggests that the sympathetic nervous system may play a physiologic role in the regulation of atriopeptin secretion.

  8. Development of the AP Technology Through Time

    NASA Astrophysics Data System (ADS)

    Charmier, F.; Martin, O.; Gariepy, R.

    2015-02-01

    This article presents the historical development of the AP Technology (Aluval, Voreppe, France) pot series starting with the AP13 in the 1960s, followed by the AP18 and the AP30 in the 1980s and 1990s. For most of the modern-era technology, from the late 1970s on, development has been based on a three-stage pattern, the first one being the pot modeling, followed by the pot prototype stage, and then the industrial stage, which fully validated the technology. This development pattern has proven to be successful since it has led to the very robust AP Technology pot design generation and a large number of greenfield smelters built in the 1990-2010 selected the AP Technology design. AP60 is the latest of this series: The development at the prototype level was initiated in the 1990s and is presented in the article. It is now followed by the first industrial realization at Jonquière with the startup in late 2013 and the full validation of the technology in mid-2014. The development of APXe, which aims at very low energy consumption, uses many common elements pertaining to the AP60 design and is presented in the article. AP Technology has also addressed the need for continuous and fast improvement of pot performances adapted to each existing client or site specifics; for this purpose, a new development methodology has recently emerged thanks to the very high modeling capabilities. This methodology, based on the validation of "technology bricks" and their integration in the final design following a strict process, is presented in the last section of this article.

  9. Operation of the APS rf gun.

    SciTech Connect

    Lewellen, J. W.

    1998-09-11

    The Advanced Photon Source (APS) has a thermionic-cathode rf gun system capable of providing beam to the APS linac. The gun system consists of a 1.6-cell thermionic-cathode rf gun, a fast kicker for beam current control, and an alpha magnet for bunch compression and injection into the APS linac line. This system is intended for use both as an injector for positron creation, and as a first beam source for the Low-Energy Undulator Test Line (LEUTL) project [1]. The first measured performance characteristics of the gun are presented.

  10. Meet the APS Editors Coffee Break

    NASA Astrophysics Data System (ADS)

    2014-03-01

    The APS Journal Editors invite you to join them for conversation and light refreshments. The Editors will be available to answer questions, discuss your ideas, and listen to your comments about the journals. All are welcome to attend.

  11. 46th APS-DPP Savannah, GA

    E-print Network

    Washington at Seattle, University of

    . Also has a natural divertor, facilitating reactor ash removal. It offers a very attractive candidate for an economic fusion reactor. #12;546th APS-DPP, November 15-19, 2004, Savannah, GA Translation of FRCs formed

  12. APS Activities with Other Professional Societies

    NASA Astrophysics Data System (ADS)

    Slakey, Francis

    2006-03-01

    In 1981, the APS Council issued a statement that opposed ``equal time'' presentation in public school science classes of creationism and evolution. The statement clarified that ``Scientific inquiry and religious beliefs are two distinct elements of the human experience. Attempts to present them in the same context can only lead to misunderstandings of both.'' The APS Council revisited the issue in 1999 when a school board in Kansas attempted to eliminate the Big Bang, among other issues, from the science curriculum. Since that time, the APS has been more directly involved in confronting efforts that would dilute the teaching of science in public school science classes. This talk will review the APS activities and describe a developing multi-science society activity.

  13. Kepler observations of rapidly oscillating Ap, ? Scuti and ? Doradus pulsations in Ap stars

    NASA Astrophysics Data System (ADS)

    Balona, L. A.; Cunha, M. S.; Kurtz, D. W.; Brandão, I. M.; Gruberbauer, M.; Saio, H.; Östensen, R.; Elkin, V. G.; Borucki, W. J.; Christensen-Dalsgaard, J.; Kjeldsen, H.; Koch, D. G.; Bryson, S. T.

    2011-01-01

    Observations of the A5p star KIC 8677585 obtained during the Kepler 10-d commissioning run with 1-min time resolution show that it is a rapidly oscillating Ap (roAp) star with several frequencies with periods near 10 min. In addition, a low frequency at 3.142 d-1 is also clearly present. Multiperiodic ? Doradus (? Dor) and ? Scuti (? Sct) pulsations, never before seen in any Ap star, are present in Kepler observations of at least three other Ap stars. Since ? Dor pulsations are seen in Ap stars, it is likely that the low frequency in KIC 8677585 is also a ? Dor pulsation. The simultaneous presence of both ? Dor and roAp pulsations and the unexpected detection of ? Sct and ? Dor pulsations in Ap stars present new opportunities and challenges for the interpretation of these stars. Since it is easy to confuse Am and Ap stars at classification dispersions, the nature of these Ap stars in the Kepler field needs to be confirmed.

  14. Ectopic expression of FaesAP3, a Fagopyrum esculentum (Polygonaceae) AP3 orthologous gene rescues stamen development in an Arabidopsis ap3 mutant.

    PubMed

    Fang, Zheng-wu; Qi, Rui; Li, Xiao-fang; Liu, Zhi-xiong

    2014-10-25

    Arabidopsis thaliana APETALA3 (AP3) and Antirrhinum majus DEFICIENS (DEF) MADS box genes are required to specify petal and stamen identity. AP3 and DEF are members of the euAP3 lineage, which arose by gene duplication coincident with radiation of the core eudicots. In order to investigate the molecular mechanisms underlying organ development in early diverging clades of core eudicots, we isolated and identified an AP3 homolog, FaesAP3, from Fagopyrum esculentum (buckwheat, Polygonaceae), a multi-food-use pseudocereal with healing benefits. Protein sequence alignment and phylogenetic analyses revealed that FaesAP3 grouped into the euAP3 lineage. Expression analysis showed that FaesAP3 was transcribed only in developing stamens, and differed from AP3 and DEF, which expressed in developing petals and stamens. Moreover, ectopic expression of FaesAP3 rescued stamen development without complementation of petal development in an Arabidopsis ap3 mutant. Our results suggest that FaesAP3 is involved in the development of stamens in buckwheat. These results also suggest that FaesAP3 holds some potential for biotechnical engineering to create a male sterile line of F. esculentum. PMID:25149019

  15. EPICS release 3.11 specific documentation -- EPICS release notes for 3.11

    SciTech Connect

    1994-01-19

    EPICS release 3.11 is now ready for user testing. A person who wants to set up a simplified application environment to boot an IOC and create databases using R3.11 should follow the directions in Appendix B, page 27, of the EPICS Source/Release Control Manual, Sept. 20, 1993. The R3.11 EPICS path at ANL/APS is /net/phebos/epics/R3.11 so the command to get the new release is /net/phebos/epics/R3.11/Unix/share/bin/getrel /net/phebos/epics/R3.11. An existing R3.8 short form report can be copied to this new directory and used to create a database. ANL/APS is currently testing an Application Developers Source/Release control system. It is not yet ready for general distribution. Attached are the EPICS R3.11 release notes.

  16. Internet: http://ue.eu.int E-mail: press.office@consilium.eu.int

    E-print Network

    ...........................................................................................................6 STEM CELL RESEARCH THIS PRESS RELEASE COVERS ITEMS DISCUSSED ON 26.11.2003 - RESEARCH ONLY - 2547th Council meeting - COMPETITIVENESS - (Internal market, Industry and Research) Brussels, 26 November 2003 President : Mrs Letizia

  17. Bulletin of the American Meteorological Society EARLY ONLINE RELEASE

    E-print Network

    California at Los Angeles, University of

    Bulletin of the American Meteorological Society EARLY ONLINE RELEASE This is a preliminary PDF-00034.1, in press. © 2015 American Meteorological Society AMERICAN METEOROLOGICAL SOCIETY TECHNICAL REPORT R-451

  18. Tank 241-AP-107, grab samples 7AP-97-1, 7AP-97-2 and 7AP-97-3 analytical results for the final report

    SciTech Connect

    Steen, F.H.

    1997-12-22

    This document is the final report for tank 241-AP-107 grab samples. Three grab samples were collected from riser 1 on September 11, 1997. Analyses were performed on samples 7AP-97-1, 7AP-97-2 and 7AP-97-3 in accordance with the Compatibility Grab Sampling and Analysis Plan (TSAP) (Sasaki, 1997) and the Data Quality Objectives for Tank Farms Waste Compatibility Program (DQO) (Rev. 1: Fowler, 1995; Rev. 2: Mulkey and Nuier, 1997). The analytical results are presented in the data summary report (Table 1). A notification was made to East Tank Farms Operations concerning low hydroxide in the tank and a hydroxide (caustic) demand analysis was requested. The request for sample analysis (RSA) (Attachment 2) received for AP-107 indicated that the samples were polychlorinated biphenyl (PCB) suspects. Therefore, prior to performing the requested analyses, aliquots were made to perform PCB analysis in accordance with the 222-S Laboratory administrative procedure, LAP-101-100. The results of this analysis indicated that no PCBs were present at 50 ppm and analysis proceeded as non-PCB samples. The results and raw data for the PCB analysis will be included in a revision to this document. The sample breakdown diagrams (Attachment 1) are provided as a cross-reference for relating the tank farm customer identification numbers with the 222-S Laboratory sample numbers and the portion of sample analyzed.

  19. Automated Plasma Spray (APS) process feasibility study

    NASA Technical Reports Server (NTRS)

    Fetheroff, C. W.; Derkacs, T.; Matay, I. M.

    1981-01-01

    An automated plasma spray (APS) process was developed to apply two layer (NiCrAlY and ZrO2-12Y2O3) thermal barrier coatings to aircraft and stationary gas turbine engine blade airfoils. The APS process hardware consists of four subsystems: a mechanical positioning subsystem incorporating two interlaced six degree of freedom assemblies (one for coating deposition and one for coating thickness monitoring); a noncoherent optical metrology subsystem (for in process gaging of the coating thickness buildup at specified points on the specimen); a microprocessor based adaptive system controller (to achieve the desired overall thickness profile on the specimen); and commerical plasma spray equipment. Over fifty JT9D first stage aircraft turbine blade specimens, ten W501B utility turbine blade specimens and dozens of cylindrical specimens were coated with the APS process in preliminary checkout and evaluation studies. The best of the preliminary turbine blade specimens achieved an overall coating thickness uniformity of 53 micrometers (2.1 mils), much better than is achievable manually. Comparative evaluations of coating thickness uniformity for manually sprayed and APS coated specimens were performed. One of the preliminary turbine blade evaluation specimens was subjected to a torch test and metallographic evaluation. Some cylindrical specimens coated with the APS process survived up to 2000 cycles in subsequent burner rig testing.

  20. Linkping University Electronic Press

    E-print Network

    Zhao, Yuxiao

    -term goals of LiU E-Press are to continue in this vein. In the short term this requires a focus on research databases. 1.2 Users Users comprise researchers, readers, authors and administrators. The authors who

  1. ARTICLE IN PRESS UNCORRECTEDPROOF

    E-print Network

    and Linear fracture Mechanics. To cite this article: J.-B. Colliat et al., C. R. Mecanique ··· (····). © 2007 rupture. Pour citer cet article : J.-B. Colliat et al., C. R. Mecanique ··· (····). © 2007 PublishedARTICLE IN PRESS UNCORRECTEDPROOF Please cite this article in press as: J.-B. Colliat et al

  2. Plyler Prize and APS Fellow Introductions

    NASA Astrophysics Data System (ADS)

    Nathanson, Gilbert

    2014-03-01

    The Division of Chemical Physics is delighted to announce the 2013 APS Fellows sponsored by DCP and to honor the 2014 Earl K. Plyler Prize Award winner. The new APS Fellows are: Ilan Benjamin, Hua Guo, Manos Mavrikakis, Josef Paldus, Joern Siepmann, Hans-Peter Steinrueck, Douglas Tobias, Angela Wilson, and Yijing Yan. The citations for each awardee will be read out loud. I will also introduce Prof. Lai-Sheng Wang of the Department of Chemistry at Brown University, who was awarded the 2014 Plyler Prize for Molecular Spectroscopy and Dynamics. Please come learn about these extraordinary scientists during this prize session. Prof. Wang's Plyler Prize talk will follow immediately after this introduction. For more information, see http://www.aps.org/units/dcp/.

  3. Developmental Cell, Vol. 1, 215225, August, 2001, Copyright 2001 by Cell Press The Sex Determination Gene doublesex Regulates

    E-print Network

    Baker, Bruce S.

    - the disc. In both sexes, the anal primordium occupiesders (Figure 1A; reviewed in Serrano and ODevelopmental Cell, Vol. 1, 215­225, August, 2001, Copyright 2001 by Cell Press The Sex Determination Gene doublesex Regulates the A/P Organizer to Direct Sex-Specific Patterns of Growth

  4. Neuron, Vol. 21, 271274, August, 1998, Copyright 1998 by Cell Press They're Playing Our Song: Minireview

    E-print Network

    Gentner, Timothy

    Neuron, Vol. 21, 271­274, August, 1998, Copyright ©1998 by Cell Press They're Playing Our Song- disciplines of neuroscience; the use of these new ap- tions of neurons in HVc appear to code for song syllables proaches has, in turn, produced principles of general (large units within songs), while RA neurons

  5. The White House Office of the Press Secretary

    E-print Network

    Rathbun, Julie A.

    The White House Office of the Press Secretary For Immediate Release April 15, 2010 Remarks's in the house. (Applause.) Four decades ago, Buzz became a legend. But in the four decades since he's also been in Congresswoman Kosmas. Please give her a big round of applause. (Applause.) I also want to thank everybody

  6. Tank 241-AP-106, grab samples, 6AP-96-1 through 6AP-96-3 analytical results for the final report

    SciTech Connect

    Esch, R.A., Westinghouse Hanford

    1996-12-11

    This document is the final report for tank 241-AP-106 grab samples. This document presents the analytical results for three samples (6AP-96-1, 6AP-96-2 and 6AP-96-3) taken from riser 1 @ 150{degrees} of tank 241-AP-1 06 on September 12, 1996. Analyses were performed in accordance with the Compatibility Grab Sampling and Analysis Plan (TSAP) (Sasaki, 1996) and the Data Quality Objectives for Tank Farms Waste Compatibility Program (DQO) (Fowler, 1995).

  7. Two Successful Approaches to Teaching AP Government

    ERIC Educational Resources Information Center

    Ladd, Brian; Stepp, Heidi

    2013-01-01

    Amador Valley High School, in Pleasanton, California, uses two unique approaches to teaching Advanced Placement Government and Politics. AP Government consists of six units: Constitutional Underpinnings; Political Behavior and Political Beliefs; Mass Media, Interest Groups, and Political Parties; Institutions of Government; Civil Liberties and…

  8. ACADEMIC PROBATION (AP) Causal Event(s)

    E-print Network

    Mootha, Vamsi K.

    ACADEMIC PROBATION (AP) Causal Event(s) or triggers Remedial Action Communication Documentation and must be constructed to promote professional development. Students on Academic Probation are not allowed the experience. Student receives written notice regarding PRB concerns and placement on Academic Probation

  9. Advanced Placement Program (AP) Examination Minimum

    E-print Network

    Mohaghegh, Shahab

    Advanced Placement Program (AP) Examination Minimum Score Credit Hours Course Equivalent ART (Studio) Studio Art Drawing 3 3 ART 111 Studio Art-2-D Design 3 or 4 3 Open credit ART Studio Art-2-D Science A 3 3 Open credit CS Computer Science AB 3 6 Open credit CS (6 units maximum for both tests

  10. Gapminder: An AP Human Geography Lab Assignment

    ERIC Educational Resources Information Center

    Keller, Kenneth H.

    2012-01-01

    This lesson is designed as a lab assignment for Advanced Placement (AP) Human Geography students wherein they use the popular Gapminder web site to compare levels of development in countries from different world regions. For this lesson, it is important for the teacher to practice with Gapminder before giving the assignment to students. (Contains…

  11. The Promise of AP World History

    ERIC Educational Resources Information Center

    Saldaña, Cristóbal T.

    2013-01-01

    AP World History is the ideal history course. It introduces students to 10,000 years of world history, and demands critical reading, critical writing, and critical thinking skills on the part of both the teacher and the students. It requires students to build their expertise in reading their textbook, and places demands on the teacher to assign…

  12. Structuring the AP Art History Course

    ERIC Educational Resources Information Center

    Herscher, Walter R.

    2013-01-01

    While AP (Advanced Placement) Art History may be taught within the art department in many schools, social studies teachers are equally capable of teaching the course well. They have the historical background to discuss the reasons for changes in art styles. A teacher's preparation is similar to teaching a course stressing political history,…

  13. A Timing-Based Scheme for Rogue AP Detection

    E-print Network

    Li, Qun

    A Timing-Based Scheme for Rogue AP Detection Hao Han, Bo Sheng, Member, IEEE, Chiu C. Tan, Member a practical timing-based technique that allows the user to avoid connecting to rogue APs. Our detection scheme such as SSID, MAC address, RSSI, and clock skew. A rogue AP is detected when its identities are compared

  14. Book Eyes Impact of AP Classes and Exams

    ERIC Educational Resources Information Center

    Viadero, Debra

    2010-01-01

    At a time of mushrooming interest in Advanced Placement (AP) tests, a new book, "AP: A Critical Examination of the Advanced Placement Program," assembles studies on how capable the program is of meeting the increasingly diverse expectations held up for it. Growing out of a symposium held at Harvard in 2007, the book focuses on AP science courses…

  15. Filter Press Building 

    E-print Network

    Bush, W. M.

    1986-01-01

    substantially lower operating costs and its concept matched the state of-the-art theme of the project and was developed with the full cooperation of the consultant. The final design, a state-of-the-art sludge dewatering system, resulted in a project with a...-of-the-art sludge dewatering system. This new system utilized an automatic filter press having the unique capability of removing 50% of , the water from the water pollution control , center's treated sludge. The new filter press would be among two state...

  16. Whoopers Released

    USGS Multimedia Gallery

    A Whooping crane chick is released into a temporary pen to acclimate before being released into the wild.  Four of the endangered chicks, hatched and raised by their parents at the U.S. Geological Survey’s Patuxent Wildlife Research Center in Laurel, Maryland, were released on Necedah Nat...

  17. 77 FR 24480 - Application for New Awards; Advanced Placement (AP) Test Fee Program-Reopening the AP Test Fee...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-24

    .... ACTION: Notice reopening the AP Test Fee fiscal year 2012 competition. Catalog of Federal Domestic Assistance (CFDA) Number: 84.330B. SUMMARY: On February 15, 2012, we published in the Federal Register (77 FR... Application for New Awards; Advanced Placement (AP) Test Fee Program--Reopening the AP Test Fee Fiscal...

  18. COMMUNIQUE DE PRESSE / COMMUNIQUE DE PRESSE / COMMUNIQUE DE PRESSE Ecole Centrale Paris

    E-print Network

    Paragios, Nikos

    COMMUNIQUE DE PRESSE / COMMUNIQUE DE PRESSE / COMMUNIQUE DE PRESSE Ecole Centrale Paris Grande Voie.ecp.fr - https://twitter.com/centraleparis Centrale Paris has won a new Erasmus Mundus (Paris, Friday July 19, 2013) ­ Leading a consortium of of 12 European, Japanese and Korean partners, Centrale Paris has been

  19. COMMUNIQUE DE PRESSE / COMMUNIQUE DE PRESSE / COMMUNIQUE DE PRESSE Ecole Centrale Paris

    E-print Network

    Paragios, Nikos

    COMMUNIQUE DE PRESSE / COMMUNIQUE DE PRESSE / COMMUNIQUE DE PRESSE Ecole Centrale Paris Grande.ecp.fr https://twitter.com/centraleparis Launching of T.I.M.E. Alumni Association (Paris, October 24th , 2013.I.M.E. assocoation in the presence of Ecole Centrale Paris representatives such as Pr. Hervé Biausser, President

  20. COMMUNIQUE DE PRESSE / COMMUNIQUE DE PRESSE / COMMUNIQUE DE PRESSE Ecole Centrale Paris

    E-print Network

    Paragios, Nikos

    COMMUNIQUE DE PRESSE / COMMUNIQUE DE PRESSE / COMMUNIQUE DE PRESSE Ecole Centrale Paris Grande.ecp.fr https://twitter.com/centraleparis ECOLES CENTRALES & ESSEC BUSINESS SCHOOL ALUMNI CAREER FORUM (Paris, October 14th 2013) ECOLE CENTRALE PARIS in partnership with ESSEC BUSINESS SCHOOL and the Group of ECOLE

  1. COMMUNIQUE DE PRESSE / COMMUNIQUE DE PRESSE / COMMUNIQUE DE PRESSE Ecole Centrale Paris

    E-print Network

    Paragios, Nikos

    COMMUNIQUE DE PRESSE / COMMUNIQUE DE PRESSE / COMMUNIQUE DE PRESSE Ecole Centrale Paris Grande.ecp.fr https://twitter.com/centraleparis Ecole Centrale Paris will participate in the India-France Technology Summit (Paris, October 21th 2013) - Ecole Centrale Paris will participate in the first edition

  2. COMMUNIQUE DE PRESSE / COMMUNIQUE DE PRESSE / COMMUNIQUE DE PRESSE Ecole Centrale Paris

    E-print Network

    Paragios, Nikos

    COMMUNIQUE DE PRESSE / COMMUNIQUE DE PRESSE / COMMUNIQUE DE PRESSE Ecole Centrale Paris Grande Voie on Centrale Paris campus on October 10th and 11th , 2013 as the Ecole Centrale Paris is coordinating this new Channels EcoleCentraleParis #12;

  3. Final report for tank 241-AP-108, grab samples 8AP-96-1, 8AP-96-2 and 8AP-96-FB

    SciTech Connect

    Esch, R.A.

    1996-04-19

    This document is the final report deliverable for the tank 241-AP-108 grab samples. The samples were subsampled and analyzed in accordance with the TSAP. Included in this report are the results for the Waste Compatibility analyses, with the exception of DSC and thermogravimetric analysis (TGA) results which were presented in the 45 Day report (Part 2 of this document). The raw data for all analyses, with the exception of DSC and TGA, are also included in this report.

  4. Beryllium window for an APS diagnostics beamline

    SciTech Connect

    Sheng, I.C.; Yang, B.X.; Sharma, Y.S.

    1997-09-01

    A beryllium (Be) window for an Advanced Photon Source (APS) diagnostics beamline has been designed and built. The window, which has a double concave axisymmetrical profile with a thickness of 0.5 mm at the center, receives 160 W/mm{sup 2} (7 GeV/100 mA stored beam) from an undulator beam. The window design as well as thermal and thermomechanical analyses, including thermal buckling of the Be window, are presented.

  5. Cultural Diversity in AP Art History

    ERIC Educational Resources Information Center

    Bolte, Frances R.

    2006-01-01

    Teaching AP Art History is like running on a treadmill that is moving faster than a teacher can run. Many teachers are out of breath before the end of the term and wonder how in the world they can cover every chapter. Because time is short and art from pre-history through to the present, including the non-European traditions, must be covered, this…

  6. NATURE METHODS | VOL.2 NO.9 | SEPTEMBER 2005 | 699 Cold Spring Harbor Laboratory Press PUBLISHED IN ASSOCIATION WITH

    E-print Network

    Cai, Long

    NATURE METHODS | VOL.2 NO.9 | SEPTEMBER 2005 | 699© Cold Spring Harbor Laboratory Press PROTOCOL PUBLISHED IN ASSOCIATION WITH COLD SPRING HARBOR LABORATORY PRESS Patch amperometry: high-resolution measurements of single-vesicle fusion and release Gregor Dernick1,3, Liang-Wei Gong1,3, Lucia Tabares2

  7. Neuron, Vol. 42, 653663, May 27, 2004, Copyright 2004 by Cell Press Heterosynaptic Dopamine Neurotransmission

    E-print Network

    Sulzer, David

    Neuron, Vol. 42, 653­663, May 27, 2004, Copyright 2004 by Cell Press Heterosynaptic Dopamine Center configuration suggests that dopamine release, which isSeattle, Washington 98105 elicited or by dopamine-3 Department of Psychiatry releasing drugs such as amphetamine, may not only4 Center

  8. Optically Aligned Drill Press

    NASA Technical Reports Server (NTRS)

    Adderholdt, Bruce M.

    1994-01-01

    Precise drill press equipped with rotary-indexing microscope. Microscope and drill exchange places when turret rotated. Microscope axis first aligned over future hole, then rotated out of way so drill axis assumes its precise position. New procedure takes less time to locate drilling positions and produces more accurate results. Apparatus adapted to such other machine tools as milling and measuring machines.

  9. ARTICLE IN PRESS UNCORRECTEDPROOF

    E-print Network

    Guerra, Vasco

    ARTICLE IN PRESS UNCORRECTEDPROOF Please cite this article as: V. Guerra, R. de Abreu, Comment on Communicated by P.R. Holland Abstract In a recent article [M. Consoli, E. Costanzo, Phys. Lett. A 333 (2004 a growing number of articles questioning the standard interpretation of special rela- tivity is appearing

  10. Nuclear criticality safety analysis of isostatic press

    SciTech Connect

    Clark, H.K.

    1988-01-01

    In response to your request a nuclear criticality safety analysis was done for the isostatic press for conditions that were specified. Under normal conditions the press is subcritical by a large margin. It is considered remotely possible, however, that the polyurethane compaction bag might rupture and release its contents. To prevent criticality from occurring should the contents be dispersed in the water in the press poison plates have been provided. The design of the plates has been altered from that previously analyzed, and it is desirable to substitute some other material for the cadmium sheet originally proposed. It was calculated that with stainless steel plates containing at least 1.0% natural boron, or alternatively, coated on both sides with 0.008'' of porcelain enamel containing high concentrations of cadmium and boron, 1.8 kg of /sup 235/U may be dispersed among the plates without becoming critical. A poison plate should also be provided above the bag and a poison ring below it if dispersal of U/sub 3/O/sub 8/ in these regions around the compaction tooling is considered credible. 16 refs., 1 figs., 3 tabs.

  11. Proactive AP Selection Method Considering the Radio Interference Environment

    NASA Astrophysics Data System (ADS)

    Taenaka, Yuzo; Kashihara, Shigeru; Tsukamoto, Kazuya; Yamaguchi, Suguru; Oie, Yuji

    In the near future, wireless local area networks (WLANs) will overlap to provide continuous coverage over a wide area. In such ubiquitous WLANs, a mobile node (MN) moving freely between multiple access points (APs) requires not only permanent access to the Internet but also continuous communication quality during handover. In order to satisfy these requirements, an MN needs to (1) select an AP with better performance and (2) execute a handover seamlessly. To satisfy requirement (2), we proposed a seamless handover method in a previous study. Moreover, in order to achieve (1), the Received Signal Strength Indicator (RSSI) is usually employed to measure wireless link quality in a WLAN system. However, in a real environment, especially if APs are densely situated, it is difficult to always select an AP with better performance based on only the RSSI. This is because the RSSI alone cannot detect the degradation of communication quality due to radio interference. Moreover, it is important that AP selection is completed only on an MN, because we can assume that, in ubiquitous WLANs, various organizations or operators will manage APs. Hence, we cannot modify the APs for AP selection. To overcome these difficulties, in the present paper, we propose and implement a proactive AP selection method considering wireless link condition based on the number of frame retransmissions in addition to the RSSI. In the evaluation, we show that the proposed AP selection method can appropriately select an AP with good wireless link quality, i.e., high RSSI and low radio interference.

  12. Managing Pesticide Resistance in Potato Health Management, ed. D. Johnson. APS Press

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Pesticides exert a selection pressure on pest populations and pests that are not controlled may produce progeny with genetic resistance to the pesticide. Pesticide classification systems based on site/mode of action have been developed and knowing a pesticides’s mode/site of action is key to planni...

  13. Managing Weeds in Potato Health Management, ed. D. Johnson. APS Press

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Weeds must be managed throughout the entire crop rotation to optimize potato tuber yield and quality. Understanding factors that promote weed species and allow them to persist in crop rotations is key to designing cropping systems that discourage and reduce the impact of weeds. Weeds can be best man...

  14. Applying Pesticides in Potato Health Management, ed. D. Johnson. APS Press

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Pesticides are an important component of most management programs for nematodes, diseases, weeds, and insects that impact yield and/or quality in potatoes. The appropriate pesticide, correct timing of application, effective rate, and appropriate method of application must be selected for effective p...

  15. ARTICLE IN PRESS UNCORRECTEDPROOF

    E-print Network

    Poli, Riccardo

    ARTICLE IN PRESS UNCORRECTEDPROOF JID:ARTINT AID:2206 /FLA [m3SC+; v 1.60; Prn:26/05/2006; 14:33] P 23 24 24 25 25 26 26 27 27 28 28 29 29 30 30 31 31 32 32 33 33 34 34 35 35 36 36 37 37 38 38 39 39 40, UK Received 12 August 2005; received in revised form 11 April 2006; accepted 24 April 2006 Abstract

  16. ARTICLE IN PRESS UNCORRECTEDPROOF

    E-print Network

    Herard, Jean-Marc

    ARTICLE IN PRESS UNCORRECTEDPROOF S1631-0721(02)01482-1/FLA AID:1482 Vol.330(0) P.1 (1-6) CRAgroup 2002/03/18 Prn:24/05/2002; 9:00 F:PXPP1482.tex by:JOL p. 1 C. R. Mecanique 330 (2002) 1­6 Hybrid is valid for the exact Godunov scheme and some approximate Godunov schemes. To cite this article: T

  17. ARTICLE IN PRESS UNCORRECTEDPROOF

    E-print Network

    , control and optimization. To cite this article: A. Ibrahimbegovic, C. R. Mecanique ··· (····). 2003 en optimisation. Pour citer cet article : A. Ibrahimbegovic, C. R. Mecanique ··· (····). 2003ARTICLE IN PRESS UNCORRECTEDPROOF S1631-0721(03)00062-7/FLA AID:42 Vol.···(···) P.1 (1-12) ELSGMLTM

  18. ARTICLE IN PRESS UNCORRECTEDPROOF

    E-print Network

    Madariaga, Raúl

    citer cet article : S. Peyrat et al., C. R. Mecanique 330 (2002) 1­14. 2002 Académie des sciencesARTICLE IN PRESS UNCORRECTEDPROOF S1631-0721(02)01455-9/FLA AID:1455 Vol.330(0) P.1 (1-14) CRAgroup 2002/03/18 Prn:19/03/2002; 13:41 F:PXPP1455.tex by:ES p. 1 C. R. Mecanique 330 (2002) 1­14 DOSSIER

  19. Notice to fruit growers and nurserymen relative to the naming and release of GulfSnow peach

    Technology Transfer Automated Retrieval System (TEKTRAN)

    GulfSnow peach is jointly released for grower trial by the U.S. Department of Agriculture, Agricultural Research Service (Byron, GA), Georgia Agricultural Experiment Station and Florida Agricultural Experiment Station. GulfSnow was previously tested as AP06-09W and originated from a cross of AP98-3...

  20. The APS machine protection system (MPS)

    SciTech Connect

    Fuja, R.; Berg, B.; Arnold, N.

    1996-08-01

    The machine protection system (MPS) that protects the APS storage ring vacuum chamber from x-ray beams, is active. There are over 650 sensors monitored and networked through the MPS system. About the same number of other process variables are monitored by the much slower EPICS control system, which also has an input to the rf abort chain. The MPS network is still growing with the beam position limits detection system coming on-line. The network configuration, along with a limited description of individual subsystems, is presented.

  1. Ozone mitigation tests at the APS

    SciTech Connect

    Kuzay, T.M.; Collins, J.T.; Pisharody, M.; Job, P.K.; Wang Zhibi

    1996-09-01

    Ozone is generated in the APS experimental stations whenever the x-ray beam has a chance to interact with air. Ozone concentrations in an experimental station have to be below a certain defined limit (current OSHA regulations specify 0.08 ppm as the maximum limit) before an experimenter can reenter the hutch. This limit is said to be currently under study for a downward adjustment. One method of depleting the ozone generated in an experimental station is mitigation through either adsorption or direct destruction. In recent tests, both methods were tried using commercially available units. Test results and some analytical predictions are presented.

  2. Progress on photon-counting intensified APS

    NASA Astrophysics Data System (ADS)

    Uslenghi, Michela C.; Bonanno, Giovanni; Belluso, Massimiliano; Cali, Antonio; Timpanaro, Cristina; Cosentino, Rosario; Scuderi, Salvatore; Modica, Angelo

    2003-02-01

    We report on the progress of the activity, started one year ago, to obtain a photon counting, MCP-based detector, optimized for high count-rate. A new electronic board, hosting both the APS and the electronics processing unit, has been developed. The new architecture of the system, designed to drive the detector, to acquire the images and compute the photon event centers, is described in detail in this paper. We also report the functional tests carried out on the sub-parts of the detector along with a preliminary characterization of the system.

  3. Laser drive development for the APS Dynamic Compression Sector

    NASA Astrophysics Data System (ADS)

    Lagrange, Thomas; Swift, Damian; Reed, Bryan; Bernier, Joel; Kumar, Mukul; Hawreliak, James; Eggert, Jon; Dixit, Sham; Collins, Gilbert

    2013-06-01

    The Dynamic Compression Sector (DCS) at the APS synchrotron offers unprecedented possibilities for x-ray diffraction and scattering measurements in-situ during dynamic loading, including single-shot data collection with x-ray energies high enough (tens of kV) to study high-Z samples in transmission as well as reflection. Dynamic loading induced by laser ablation is an important component of load generation, as the duration, strain rate, and pressure can be controlled via the energy, spot size, and pulse shape. Using radiation hydrodynamics simulations, validated by experiments at several laser facilities, we have investigated the relationship between irradiance history and pressure for ablative loads designed to induce shock and ramp loading in the nanosecond to microsecond range, and including free ablation and also ablation confined by a transparent substrate. We have investigated the effects of lateral release, which constrains the minimum diameter of the focal spot for a given drive duration. In this way, we are able to relate the desired drive conditions to the total laser energy needed, which dictates the laser technologies suitable for a given type of experiment. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

  4. Radiation characteristics of scintillator coupled CMOS APS for radiography conditions

    NASA Astrophysics Data System (ADS)

    Kim, Kwang Hyun; Kim, Soongpyung; Kang, Dong-Won; Kim, Dong-Kie

    2006-11-01

    Under industrial radiography conditions, we analyzed short-term radiation characteristics of scintillator coupled CMOS APS (hereinafter SC CMOS APS). By means of experimentation, the contribution of the transmitted X-ray through the scintillator to the properties of the CMOS APS and the afterimage, generated in the acquired image even at low dose condition, were investigated. To see the transmitted X-ray effects on the CMOS APS, Fein focus™ X-ray machine, two scintillators of Lanex™ Fine and Regular, and two CMOS APS array of RadEye™ were used under the conditions of 50 kV p/1 mAs and 100 kV p/1 mAs. By measuring the transmitted X-ray on signal and Noise Power Spectrum, we analytically examined the generation mechanism of the afterimage, based on dark signal or dark current increase in the sensor, and explained the afterimage in the SC CMOS APS.

  5. Evaluating EPA’s AP-42 development methodology to convert or rerate current AP-42 datasets

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In August 2013, the U.S. Environmental Protection Agency’s (EPA) published their new methodology for updating the Compilation of Air Pollution Emission Factors (AP-42). The “Recommended Procedures for Development of Emissions Factors and Use of the WebFIRE Database” instructs that the ratings of the...

  6. A comparison of impulse drying to double felted pressing on pilot- scale shoe presses and roll presses

    SciTech Connect

    Orloff, D.I.

    1992-08-01

    Pilot-scale shoe press and roll press experiments have been conducted to compare impulse drying and double felted pressing. Both ceramic coated and Beloit Type C press rolls have been evaluated. The experiments show that impulse drying can provide significantly higher outgoing solids than double felled pressing at the same impulse. For example, at an impulse of 0.234 MPa seconds (34 psi seconds), sheets at an ingoing solids of 52% were impulse dried (using the Beloit Type C press roll) to 68% solids while optimized double felled pressing could only yield press dryness of, at most, 60%.

  7. Tank 241-AP-108 grab sampling and analysis plan

    SciTech Connect

    Baldwin, J.H., Fluor Daniel Hanford

    1997-02-07

    This Sampling and Analysis Plan (SAP) will identify characterization objectives for sample collection, laboratory analytical evaluation, and reporting requirements for tank 241-AP-108 (AP 108). It is written in accordance with the Tank 241-AP-108 Tank Characterization Plan, the Tank Safety Screening Data Quality Objective, the 242-A Evaporator Liquid Effluent Retention Facility Data Quality Objectives, and the Data Quality Objectives for Tank Farms Waste Compatibility Program.

  8. The APS control system network upgrade.

    SciTech Connect

    Sidorowicz, K. v.; Leibfritz, D.; McDowell, W. P.

    1999-10-22

    When it was installed,the Advanced Photon Source (APS) control system network was at the state-of-the-art. Different aspects of the system have been reported at previous meetings [1,2]. As loads on the controls network have increased due to newer and faster workstations and front-end computers, we have found performance of the system declining and have implemented an upgraded network. There have been dramatic advances in networking hardware in the last several years. The upgraded APS controls network replaces the original FDDI backbone and shared Ethernet hubs with redundant gigabit uplinks and fully switched 10/100 Ethernet switches with backplane fabrics in excess of 20 Gbits/s (Gbps). The central collapsed backbone FDDI concentrator has been replaced with a Gigabit Ethernet switch with greater than 30 Gbps backplane fabric. Full redundancy of the system has been maintained. This paper will discuss this upgrade and include performance data and performance comparisons with the original network.

  9. On the Mechanisms for Defeating AP Projectiles

    NASA Astrophysics Data System (ADS)

    Rosenberg, Z.; Dekel, E.; Ashuach, Y.; Yeshurun, Y.

    The important mechanisms for defeating armor piercing (AP) projectiles are reviewed in this paper. These mechanisms are based on the compressive strength of the target material (its inherent resistance to penetration) and on the asymmetrical forces which it exerts on the threat, through proper geometrical arrangements. We discuss the basic features of the resistance to penetration, starting with the classical analysis of the cavity expansion process in elasto-plastic solids. This property of the target is responsible for the deceleration of hard cored projectiles and for the erosion of long rods, under normal impact conditions. We then discuss the asymmetrical interaction of AP projectiles with inclined plates (metals and polymers) and with ceramic spheres. These asymmetric forces are responsible for their deflection and breakup. Our work combines experimental observations with numerical simulations and engineering models, which enhance the understanding of the various phenomena encountered in these complex situations. This understanding is necessary for optimizing the performance of any armor design against a given threat.

  10. Verotoxin-1 induces tissue factor expression in human umbilical vein endothelial cells through activation of NF-kappaB/Rel and AP-1.

    PubMed

    Ishii, H; Takada, K; Higuchi, T; Sugiyama, J

    2000-10-01

    This study examined the effect of verotoxin-1 (VT-1), which is released from Escherichia coli O157:H7, on endothelial expression of tissue factor (TF), a cofactor required to initiate blood coagulation. In order to elucidate the molecular basis for development of hemolytic uremic syndrome (HUS) in patients infected with E. coli O157:H7, human umbilical vein endothelial cells (HUVECs) were exposed to purified VT-1. VT-1 increased both TF activity and TF mRNA in HUVECs without loss of cell viability in a time- and dose-dependent manner from 0.1 to 10 ng/ml VT-1. Nuclear proteins extracted from VT-1-stimulated HUVECs bound to the consensus NF-kappaB/Rel and AP-1 binding oligonucleotides in a dose-dependent manner within 2 h after the stimulation in electrophoretic mobility shift assays (EMSA). Nuclear proteins from VT-1-stimulated HUVECs formed two complexes with the NF-kappaB/Rel binding motif in the human TF promoter (TF-kappaB motif). The supershift assays, using antibodies for human p65, p50 or c-Rel, indicated that the lower complex was composed of p65/p50 and the higher complex was a p65 homo- or hetero-dimer with the Rel family, except c-Rel. The human TF promoter contains two AP-1 binding sites, the proximal and distal AP-1 binding sites. The supershift assays indicated that AP-1 containing mainly c-Jun and JunD, positively bound to the proximal AP-1 motif of TF (TF-AP-1). The distal TF-AP-1 motif did not show positive binding with nuclear proteins from VT-1-stimulated HUVECs. Pretreatment of HUVECs with curcumin, an inhibitor of NF-kappaB/Rel activation, synthesis of c-Jun mRNA and binding of activated AP- I with AP-binding oligonucleotide, prevented the VT-1 induced increase in TF mRNA and activity in VT-1-stimulated HUVECs. Curcumin also inhibited NF-kappaB and AP-1 binding to TF-kappaB and proximal TF-AP-1 oligonucleotides, respectively, in a dose-dependent manner. The present work suggests that both the NF-kappaB/Rel and AP-1 activated in endothelial cells by stimulation with VT-1 binds to the TF-kappaB and proximal AP-1 binding sites, respectively, of the TF promoter. PMID:11057875

  11. CIDER PRESS, LOOKING SOUTHEAST ACROSS THE SCHUYLKILL RIVER. THIS PRESS, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CIDER PRESS, LOOKING SOUTHEAST ACROSS THE SCHUYLKILL RIVER. THIS PRESS, CARVED OUT OF A LARGE BOULDER AT THE RIVERS EDGE, PROBABLY DATES FROM THE LIFETIME OF JOHN BARTRAM, IF NOT TO THE SWEDISH SETTLERS BEFORE HIM. THE IRON FENCE IS A NINETEENTH-CENTURY ADDITION - John Bartram House & Garden, 54th Street & Lindbergh Boulevard, Philadelphia, Philadelphia County, PA

  12. PRESS SHOP. SEVEN BLISS PRESSES STAMP OUT A VARIETY OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PRESS SHOP. SEVEN BLISS PRESSES STAMP OUT A VARIETY OF CARTRIDGE AND SHELL CASINGS. THIS DEPARTMENT WAS TRANSFORMED FROM A MONEY-LOSING OPERATION TO A PROFIT CENTER UNDER THE FIRST WORKER-MANAGED QUALITY CIRCLE IN THE PLANT. - American Brass Foundry, 70 Sayre Street, Buffalo, Erie County, NY

  13. News Release FOR IMMEDIATE RELEASE

    E-print Network

    Acton, Scott

    worked with DARS' Woodrow Wilson Rehabilitation Center in Fishersville to hire several of the center impact on Hershey's recruitment efforts. Rick Sizemore, director of Woodrow Wilson Rehabilitation CenterNews Release FOR IMMEDIATE RELEASE May 9, 2014 For more information, contact Cindy S. Roberts Cindy.Roberts

  14. The AP-1 transcription factor Fra1 inhibits follicular B cell differentiation into plasma cells

    PubMed Central

    Grötsch, Bettina; Brachs, Sebastian; Lang, Christiane; Luther, Julia; Derer, Anja; Schlötzer-Schrehardt, Ursula; Bozec, Aline; Fillatreau, Simon; Berberich, Ingolf; Hobeika, Elias; Reth, Michael; Wagner, Erwin F.; Schett, Georg

    2014-01-01

    The cornerstone of humoral immunity is the differentiation of B cells into antibody-secreting plasma cells. This process is tightly controlled by a regulatory gene network centered on the transcriptional repressor B lymphocyte–induced maturation protein 1 (Blimp1). Proliferation of activated B cells is required to foster Blimp1 expression but needs to be terminated to avoid overshooting immune reactions. Activator protein 1 (AP-1) transcription factors become quickly up-regulated upon B cell activation. We demonstrate that Fra1, a Fos member of AP-1, enhances activation-induced cell death upon induction in activated B cells. Moreover, mice with B cell–specific deletion of Fra1 show enhanced plasma cell differentiation and exacerbated antibody responses. In contrast, transgenic overexpression of Fra1 blocks plasma cell differentiation and immunoglobulin production, which cannot be rescued by Bcl2. On the molecular level, Fra1 represses Blimp1 expression and interferes with binding of the activating AP-1 member c-Fos to the Blimp1 promoter. Conversely, overexpression of c-Fos in Fra1 transgenic B cells releases Blimp1 repression. As Fra1 lacks transcriptional transactivation domains, we propose that Fra1 inhibits Blimp1 expression and negatively controls plasma cell differentiation through binding to the Blimp1 promoter. In summary, we demonstrate that Fra1 negatively controls plasma cell differentiation by repressing Blimp1 expression. PMID:25288397

  15. The AP2-like gene NsAP2 from water lily is involved in floral organogenesis and plant height.

    PubMed

    Luo, Huolin; Chen, Sumei; Jiang, Jiafu; Teng, Nianjun; Chen, Yu; Chen, Fadi

    2012-07-01

    APETALA2 (AP2) genes are ancient and widely distributed among the seed plants, and play an important role during the plant life cycle, acting as key regulators of many developmental processes. In this study, an AP2 homologue, NsAP2, was characterized from water lily (Nymphaea sp. cv. 'Yellow Prince') and is believed to be rather primitive in the evolution of the angiosperms. In situ RNA hybridization showed that NsAP2 transcript was present in all regions of the floral primordium, but had the highest level in the emerging floral organ primordium. After the differentiation of floral organs, NsAP2 was strongly expressed in sepals and petals, while low levels were found in stamens and carpels. The NsAP2 protein was suggested to be localized in the cell nucleus by onion transient expression experiment. Overexpression of NsAP2 in Arabidopsis led to more petal numbers, and Arabidopsis plants expressing NsAP2 exhibited higher plant height, which may be a result of down-regulated expression of GA2ox2 and GA2ox7. Our results indicated that the NsAP2 protein may function in flower organogenesis in water lily, and it is a promising gene for plant height improvement. PMID:22591856

  16. The CIA and the Press.

    ERIC Educational Resources Information Center

    Carvalho, Bernardo A.

    The involvement of the Central Intelligence Agency (CIA) with both United States and foreign news media has been recorded in numerous publications. This report reviews the important aspects of the CIA-press relationships as they have appeared in print and discusses the implications of these relationsihps for the credibility of the press. Media…

  17. Bridging the Small Press Gap.

    ERIC Educational Resources Information Center

    Hoffert, Barbara; Kinsella, Bridget

    1996-01-01

    Discusses the emergence of small presses as viable competitors in the publishing industry as a result of their growing use of trade associations, distributors, and wholesalers geared towards their particular needs. Through these intermediaries, small press offerings are entering the library market in increasing numbers. A sidebar presents contact…

  18. The Chilean Press Since Allende.

    ERIC Educational Resources Information Center

    Knudson, Jerry W.

    Based on interviews with 19 Chilean editors, government officials, heads of professional associations, and journalism education directors, this paper deals with the role of the press in Chile and with its future under the current military government. Following a review of the events concerning press control and censorship that followed the…

  19. Control units for APS power supplies

    SciTech Connect

    Despe, O.D.; Saunders, C.; McGhee, D.G.

    1993-07-01

    The Advanced Photon Source (APS) accelerator facility is made up of five major subsystems in addition to the linac: the positron accumulator ring (PAR), low energy transport (LET), booster synchrotron (SYNCH), high energy transport (HET), the storage ring (SR). Each subsystem has multiple magnet power supply combinations, some requiring multiple of operation. These magnet and power supply combinations computer controlled and monitored. The power supply control unit (PSCU) is the first layer of hardware and software above the power supply itself and is described in this paper. The description includes the basic philosophy for each of operation and how it influences the topology and of implementing control. The design of the analog reference blocks (ARBs) influenced the design of other custom functions well as the feedback controls for vibration and other dynamic corrections. The command set supported by the PSCU is discussed.

  20. Fabrication of Functionally Graded SOFC by APS

    NASA Astrophysics Data System (ADS)

    Yang, Y. Z.; Zhang, H. O.; Wang, G. L.; Xia, W. S.

    2007-12-01

    Atmospheric plasma spray (APS) was used to prepare the planar positive/electrolyte/negative (PEN) and mono-block layer built (MOLB) type PEN solid oxide fuel cells (SOFCs). On the basis of the spraying conditions optimized previously and the self-developed functionally graded powder feeder system, two types of PEN cells were fabricated. Then the microstructure and material composition of the PEN cells were analyzed. The results show that graded layers formed between the electrodes and electrolyte. Moreover, the material composition and the porosity of the graded layers vary gradually. In particular, the porosities of the resultant anode and cathode reach 32.74 and 32.24%, respectively. Using the AC complex impedance technique, the conductivity of the MOLB type composite electrode is tested. The electrical conductivity of the MOLB type composite electrode with the graded layers is larger than that without the graded layers.

  1. AP-42 ADDITIONS AND REVISIONS - RUBBER PRODUCTS MANUFACTURING

    EPA Science Inventory

    This project develops emission factors, etc., for the rubber products industry which are appended to AP-42. AP42 is a massive collection of material which describes processes which generate air emissions and presents emission factors and control effectiveness information. As res...

  2. Demo Abstract: HumanCoAP Interaction with Copper

    E-print Network

    browser for the Internet of Things based on the Constrained Application Protocol (CoAP). Current estimates foresee that the number of networked embedded devices encompassed by the Internet of Things will be vastAP protocol suite. I. INTRODUCTION The Internet of Things is the vision of interconnecting everyday objects

  3. STEP AP233 + Standard PDM = Systems Engineering PDM ?

    E-print Network

    Ulm, Universität

    STEP AP233 + Standard PDM = Systems Engineering PDM ? Roland Eckert1 , Wolfgang Mansel2 , Günther engineering environment. STEP ISO 10303 - AP233 provides an appropriate approach for integrating systems. A framework for a systems engineering PDM system is proposed and data exchange aspects discussed

  4. Performance of Project Advance Students on the AP Biology Examination.

    ERIC Educational Resources Information Center

    Mercurio, Joseph; And Others

    1984-01-01

    Compared performance of Project Advance biology students (N=60) with Advanced Placement (AP) candidates (N=15,947) nationally on College Entrance Examination Board AP biology test. The research, conducted to determine comparability of the program as valid measures of academic achievement, determined that Project Advance students scored above the…

  5. Baylor Geology | Student Profiles Applied Petroleum Studies (APS)

    E-print Network

    Lin, King-Ip "David"

    Baylor Geology | Student Profiles Applied Petroleum Studies (APS) Recruitment | 2015-2016 The joy Prospective Petroleum Industry Recruiter: The Baylor University Department of Geology is pleased to make you profiled within this brochure have participated within Baylor Geology's Applied Petroleum Studies (APS

  6. The APS SASE FEL : modeling and code comparison.

    SciTech Connect

    Biedron, S. G.

    1999-04-20

    A self-amplified spontaneous emission (SASE) free-electron laser (FEL) is under construction at the Advanced Photon Source (APS). Five FEL simulation codes were used in the design phase: GENESIS, GINGER, MEDUSA, RON, and TDA3D. Initial comparisons between each of these independent formulations show good agreement for the parameters of the APS SASE FEL.

  7. The 10th Annual AP® Report to the Nation

    ERIC Educational Resources Information Center

    College Board, 2014

    2014-01-01

    From the moment students step into an Advanced Placement Program® (AP®) classroom, they notice the difference in the teacher's approach to the subject, in the attitude of their classmates, in the new way of thinking the curriculum requires. More than just a class, AP is a community of students and educators who are passionate, curious, and…

  8. Standards and Excellence: Evidence from Advanced Placement (AP) Exams

    ERIC Educational Resources Information Center

    Dee, Thomas S.; Jacob, Brian A.

    2009-01-01

    This study assesses the effects of state exit exams on the student utilization of and performance on Advanced Placement (AP) exams. AP programs have become an increasingly popular way of providing fairly standardized and academically rigorous academic experiences that can prepare high school students for the transition to post-secondary schooling.…

  9. AP233: An Information Model for Systems Engineering

    NASA Technical Reports Server (NTRS)

    Siebes, Georg

    2009-01-01

    In today's world, information is abundant. We have no problems generating it. But we are challenged to find, organize, and exchange information. center dot A standardized model of information can help. Such a model nearly completed its development for Systems Engineering. It is referred to as AP233 (AP = Application Protocol).

  10. : The AE9/AP9 Next Generation Radiation Specification Models - Progress Report

    NASA Astrophysics Data System (ADS)

    OBrien, Paul; Johnston, W. Robert; Huston, Stuart; Ginet, Gregory

    2015-04-01

    The AE9/AP9 model has now been released to the global satellite design community. Since the release of version 1.0, we have been focused on documenting the model so that it is suitable for consideration as an international standard. We are also working on incorporating new data sources, such as THEMIS, TACSAT-4, and NASA's Van Allen Probes. Finally, we are scoping out architectural improvements to enable improvements requested by industry: improved stitching between the plasma and radiation models, local time dependence in the plasma model, longitude dependence in the electron radiation model, and solar cycle variation in the low altitude protons. We provide a brief update on the status of the model, plans for the future, and progress on international agreements.

  11. Press Release For Immediate Distribution Seattle, USA. May 8, 2008

    E-print Network

    37% less softwood logs from Russia in 2007 as compared to 2006. Although softwood log exports-term and long- term, as the costs of logs from Russia are likely to increase further. As of January 2009, the last shipments of softwood logs will be leaving Russia in late December this year. Global pulpwood

  12. www.Carolynparello.com www.beyondbenign.org PRESS RELEASE

    E-print Network

    Massachusetts at Lowell, University of

    on the challenge of a "toxic turnaround." They have seen the light, and they are going green, too. Parello for Green Chemistry Opening reception is on October 23, 2014 6:00 ­ 8:30pm WILMINGTON, MA ­ Beyond Benign and the Warner Babcock Institute for Green Chemistry, and local artist Carolyn Parello, in conjunction

  13. For Immediate Release Office of the Press Secretary

    E-print Network

    and International Trade Center Washington, D.C. President Discusses Energy Policy 11:05 A.M. EDT THE PRESIDENT to be here for the 16th annual Energy Efficiency Forum. It's an important forum. By advancing the national dialogue on the future of energy, you're helping us support the cause of energy efficiency. And that

  14. PRESS RELEASE IBM and Sabanci University take a strategic

    E-print Network

    Çetin, Müjdat

    decisions faster in research and technologies revolving around "Big Data." Those who manage data will shape competition According to many consulting companies, data analytics is one of the most popular jobs of the 21st out of data. Big Data, with its surrounding technol- ogies and ongoing research, offers businesses

  15. PRESS RELEASE THE LOUISE AND ALAN EDWARDS FOUNDATION

    E-print Network

    Shoubridge, Eric

    research project are to: `a) elucidate the potential impact of telomere shortening on pain behaviours's proposed project is titled, `Investigation of the potential relevance of telomeres in chronic inflammatory in mice; b) define telomere and cellular senescence fingerprints in various mouse models of inflammatory

  16. For Immediate Release Office of the Press Secretary

    E-print Network

    's an initiative that will reduce air pollution from power plants by 70 percent by the year 2018. It change our dependence upon foreign sources of energy; we can help with the quality of the air; we can

  17. JOINT PRESS RELEASE CITY OF GAINESVILLE POLICE DEPARTMENT

    E-print Network

    Slatton, Clint

    several times while police talked to her, so investigators are trying to determine what actually happenedStoppers at 352-372-STOP. You may also text an anonymous tip by texting keyword "GPDFL" plus your tip to 274637

  18. For Immediate Release Office of the Press Secretary

    E-print Network

    priorities: Use Technology To Increase Conservation And Energy Efficiency Promote energy efficiency and fuel-cell vehicles, residential solar energy systems, combined heat and power projects, and electricity a wide range of energy technology research and development programs to develop energy efficient next

  19. PRESS RELEASE FROM NEUROPSYCHOPHARMACOLOGY (http://www.nature.com/npp)

    E-print Network

    Cai, Long

    OF THE FOLLOWING ITEM. IF PUBLISHING ONLINE, PLEASE CARRY A HYPERLINK TO http://www.nature.com/npp/ Anesthesia be impaired in children who received general anesthesia as infants, according to a small initial study published in Neuropsychopharmacology. Animal studies have found that anesthesia causes nerve cell death

  20. NSF Web Site Press Release 10-018

    E-print Network

    Rogers, John A.

    Budget is 8-percent increase over fiscal year 2010, aligns with National Innovation Strategy The National's roots as the nation's wellspring of scientific innovation." In September of last year, the Administration unveiled a National Innovation Strategy that encourages technology and business innovation

  1. CELLULOSOMEPLUS PROJECT EU/FP7 PRESS RELEASE #1

    E-print Network

    Kisiel, Zbigniew

    materials like the organic fraction of municipal solid waste, inedible parts of plants or industrial scaling-up (Biopolis, S.A., Spain). The major bottleneck for plant biomass processing is fibre saccharification: the conversion of plant cell wall lignocellulosic biomass into fermentable sugars en route

  2. For Immediate Release Office of the Press Secretary

    E-print Network

    the world to environmental clean up to enhancing conservation and developing new sources of energy and to ensure that our country's homes and businesses have reliable, safe and affordable supplies of energy and power lines, so that energy flow is reliable. We will develop and deploy the latest technology

  3. CECAD Excellence Cluster, University of Cologne Press Release

    E-print Network

    Hartmann, Robert

    few regions in the adult brain where resident neural stem cells generate new neurons life-long, thus the molecular and cellular basis of aging-associated diseases as a mean to develop new effective therapeutic

  4. For Immediate Release Office of the Press Secretary

    E-print Network

    Rathbun, Julie A.

    as President by the Constitution and the laws of the United States of America, and to obtain recommendations's Commission on Implementation of United States Space Exploration Policy By the authority vested in me concerning implementation of the new vision for space exploration activities of the United States

  5. EIA new releases, July--August, 1995

    SciTech Connect

    1995-10-02

    This publication identifies energy related publications of the Energy Information Administration of the US Department of Energy. The topics and articles in this issue include data on residential energy use available on diskettes and Internet, natural gas price predictions, coal deliveries to electric utilities, growth in the US uranium industry, microfiche products, features and press releases, EIA`s electronic publishing system, new reports, machine-readable files, how to order EIA publications and energy data information contacts.

  6. EIA new releases, November--December 1995

    SciTech Connect

    1996-02-09

    Thus publication contains information compiled by the Energy information administration (EIA) on the following topics: heating fuel supplies; alternative fuel vehicles; natural gas production; clean air laws and coal transportation; EIA`s world Wide Web Site; EIA`s CD-ROM; Press Releases; Microfiched products; electronic publishing; new reports; machine-readable files; how to order EIA publications; and Energy Data Information Contracts.

  7. Glutamate Release.

    PubMed

    Hackett, John T; Ueda, Tetsufumi

    2015-12-01

    Our aim was to review the processes of glutamate release from both biochemical and neurophysiological points of view. A large body of evidence now indicates that glutamate is specifically accumulated into synaptic vesicles, which provides strong support for the concept that glutamate is released from synaptic vesicles and is the major excitatory neurotransmitter. Evidence suggests the notion that synaptic vesicles, in order to sustain the neurotransmitter pool of glutamate, are endowed with an efficient mechanism for vesicular filling of glutamate. Glutamate-loaded vesicles undergo removal of Synapsin I by CaM kinase II-mediated phosphorylation, transforming to the release-ready pool. Vesicle docking to and fusion with the presynaptic plasma membrane are thought to be mediated by the SNARE complex. The Ca(2+)-dependent step in exocytosis is proposed to be mediated by synaptotagmin. PMID:26012367

  8. Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes

    PubMed Central

    Sitaram, Anand; Dennis, Megan K.; Chaudhuri, Rittik; De Jesus-Rojas, Wilfredo; Tenza, Danièle; Setty, Subba Rao Gangi; Wood, Christopher S.; Sviderskaya, Elena V.; Bennett, Dorothy C.; Raposo, Graça; Bonifacino, Juan S.; Marks, Michael S.

    2012-01-01

    Cell types that generate unique lysosome-related organelles (LROs), such as melanosomes in melanocytes, populate nascent LROs with cargoes that are diverted from endosomes. Cargo sorting toward melanosomes correlates with binding via cytoplasmically exposed sorting signals to either heterotetrameric adaptor AP-1 or AP-3. Some cargoes bind both adaptors, but the relative contribution of each adaptor to cargo recognition and their functional interactions with other effectors during transport to melanosomes are not clear. Here we exploit targeted mutagenesis of the acidic dileucine–based sorting signal in the pigment cell–specific protein OCA2 to dissect the relative roles of AP-1 and AP-3 in transport to melanosomes. We show that binding to AP-1 or AP-3 depends on the primary sequence of the signal and not its position within the cytoplasmic domain. Mutants that preferentially bound either AP-1 or AP-3 each trafficked toward melanosomes and functionally complemented OCA2 deficiency, but AP-3 binding was necessary for steady-state melanosome localization. Unlike tyrosinase, which also engages AP-3 for optimal melanosomal delivery, both AP-1– and AP-3–favoring OCA2 variants required BLOC-1 for melanosomal transport. These data provide evidence for distinct roles of AP-1 and AP-3 in OCA2 transport to melanosomes and indicate that BLOC-1 can cooperate with either adaptor during cargo sorting to LROs. PMID:22718909

  9. Residual radiation studies at AP0

    SciTech Connect

    Alexander J Elwyn et al.

    2002-06-19

    The radiation environment at the NuMI experiment has received a lot of attention in the last few years in preparation for project construction. One important issue is the induced radioactivation of the components in the beam line and the shielding materials. This arises from irradiation by hadrons that are generated in the target. Since the level of the residual activity has to be considered when determining access procedures for maintenance during NuMI operation, an understanding of the properties of the remnant radiation is important. To this end, experimental studies were performed in the target vault at AP0 which is similar in design to the NuMI target area. Here 120 GeV protons bombard a target, generating the hadrons that produce the induced radioactivity. Two sets of samples each consisting of three small cylindrical or rectangular solids of iron and steel, one sample of aluminum, and one of concrete were irradiated. One set was hung just below the bottom of a module near the lithium lens (in-vault), and the other was placed on top of the modules downstream of this location (above-vault), just beneath the movable concrete roof of the vault at AP0. Further, four thin activation foils of Au, Au+Cd, In, and Al (along with small disks of the same iron, aluminum, and concrete samples discussed above) were mounted on four 10.2 cm diameter Al disks, one placed on the in-vault module and three at above-vault downstream locations as well. The radioactivity of all these materials on the 10.2 cm Al disks was determined at the Radioisotope Analysis Facility in an attempt to characterize the radionuclides produced during irradiation. The activities of the thin foils were employed in an effort to unfold a spectrum of the neutrons produced during the hadronic cascades in the target. The MARS Monte Carlo code (MO95, MO00) was used to predict and analyze the residual radiation produced during the beam irradiation. New subroutines have been developed for the MARS14 version providing reliable estimation of residual dose rates in arbitrary composite materials for arbitrary irradiation and cooling times (RA01). The results of the simulations have been compared with the measurements in Ref. (RA01) and this comparison will be summarized here.

  10. Preventing the press from engendering ethnic violence : press restraints and ethnic violence in Singapore

    E-print Network

    Saleem, Saleena Begum

    2005-01-01

    This thesis aims to find a solution to a commonly held problem of ethnic violence that is engendered by the press. Based on the premise that governmental influence on the press in the form of press restraints can prevent ...

  11. A search for rapid pulsations among nine luminous Ap stars

    NASA Astrophysics Data System (ADS)

    Freyhammer, L. M.; Kurtz, D. W.; Cunha, M. S.; Mathys, G.; Elkin, V. G.; Riley, J. D.

    2008-04-01

    The rapidly oscillating Ap (roAp) stars are of importance for studying the atmospheric structure of stars where the process of chemical element diffusion is significant. We have performed a survey for rapid oscillations in a sample of nine luminous Ap stars, selected from their location in the colour-magnitude diagram as more evolved main-sequence Ap stars that are inside the instability strip for roAp stars. Until recently this region was devoid of stars with observed rapid pulsations. We used the Very Large Telescope UV-Visual Echelle Spectrograph to obtain high time resolution spectroscopy to make the first systematic spectroscopic search for rapid oscillations in this region of the roAp instability strip. We report nine null detections with upper limits for radial velocity amplitudes of 20-65ms-1 and precisions of ? = 7-20ms-1 for combinations of Nd and Pr lines. Cross-correlations confirm these null results. At least six stars are magnetic and we provide magnetic field measurements for four of them, of which three are newly discovered magnetic stars. It is found that four stars have magnetic fields smaller than ~2kG, which according to theoretical predictions might be insufficient for suppressing envelope convection around the magnetic poles for more evolved Ap stars. Suppression of convection is expected to be essential for the opacity mechanism acting in the hydrogen ionization zone to drive the high-overtone roAp pulsations efficiently. Our null results suggest that the more evolved roAp stars may require particularly strong magnetic fields to pulsate. Three of the studied stars do, however, have magnetic fields stronger than 5kG. Based on observations collected at the European Southern Observatory, Paranal, Chile, as part of programmes 075.D-0145 (A), 078.D-0080(A), 072.D-0138(A) and 077.D-0150(A). E-mail: lmfreyhammer@uclan.ac.uk

  12. High Pressure Reverse Flow APS Engine

    NASA Technical Reports Server (NTRS)

    Senneff, J. M.

    1972-01-01

    A design and test demonstration effort was undertaken to evaluate the concept of the reverse flow engine for the APS engine application. The 1500 lb (6672 N) thrust engine was designed to operate on gaseous hydrogen and gaseous oxygen propellants at a mixture ratio of 4 and to achieve the objective performance of 435 sec (4266 Nsec/kg) specific impulse. Superimposed durability requirements called for a million-cycle capability with 50 hours duration. The program was undertaken as a series of tasks including the initial preliminary design, design of critical test components and finally, the design and demonstration of an altitude engine which could be used interchangeably to examine operating parameters as well as to demonstrate the capability of the concept. The program results are reported with data to indicate that all of the program objectives were met or exceeded within the course of testing on the program. The analysis effort undertaken is also reported in detail and supplemented with test data in some cases where prior definitions could not be made. The results are contained of these analyses as well as the test results conducted throughout the course of the program. Finally, the test data and analytical results were combined to allow recommendations for a flight weight design. This preliminary design effort is also detailed.

  13. Solving Symbolic Equations with PRESS 

    E-print Network

    Sterling, L.; Bundy, Alan; Byrd, L.; O'Keefe, R.; Silver, B.

    1982-01-01

    We outline a program, PRESS (PRolog Equation Solving System) for solving symbolic, transcendental, non-differential equations. The methods used for solving equations are described, together with the service facilities. The ...

  14. The effects of APS star tracker detection sensitivity

    NASA Astrophysics Data System (ADS)

    Zhang, Huaxun; Li, Jie

    2008-12-01

    Detection sensitivity is an important parameter of star tracker, which can express detecting limit of the weakest detected visual star magnitude. In this paper, the expressions of APS star detected signal and APS noise are given, so signal-noise ratio (SNR) of star tracker can be obtained. And the detection sensitivity model is obtained from SNR criterion of star target detected, star detecting probability is analyzed. Moreover the evaluation modal of the detection sensitivity in star system is deducted. The effects of detection sensitivity of APS star tracker were discussed.

  15. A new gap separation mechanism for APS insertion devices.

    SciTech Connect

    Trakhtenberg, E. M.; Tcheskidov, V.; Den Hartog, P. K.; Deriy, B.; Erdmann, M.; Makarov, O.; Moog, E. R.

    1999-10-25

    A new gap separation mechanism for use with the standard Advanced Photon Source (APS) 3.3-cm-period undulator magnetic structures has been designed and built and the first system has been installed in the APS storage ring. The system allows a minimum magnetic gap of 10 mm for use with the APS 8-mm insertion device vacuum chambers. The mechanism is a bolted steel frame structure with a simple 4-motor mechanical drive train. The control system uses servomotors with incremental rotary encoders and virtual absolute linear encoders.

  16. apGA: An adaptive parallel genetic algorithm

    SciTech Connect

    Liepins, G.E. ); Baluja, S. )

    1991-01-01

    We develop apGA, a parallel variant of the standard generational GA, that combines aggressive search with perpetual novelty, yet is able to preserve enough genetic structure to optimally solve variably scaled, non-uniform block deceptive and hierarchical deceptive problems. apGA combines elitism, adaptive mutation, adaptive exponential scaling, and temporal memory. We present empirical results for six classes of problems, including the DeJong test suite. Although we have not investigated hybrids, we note that apGA could be incorporated into other recent GA variants such as GENITOR, CHC, and the recombination stage of mGA. 12 refs., 2 figs., 2 tabs.

  17. A New Photon Counting Detector: Intensified CMOS-APS

    NASA Astrophysics Data System (ADS)

    Bonanno, G.; Belluso, M.; Cali, A.; Carbone, A.; Cosentino, R.; Modica, A.; Scuderi, S.; Timpanaro, C.; Uslenghi, M.

    A new type of position sensor (CMOS-APS) used as readout system in MCP-based intensified photon counter is presented. Thanks to CMOS technology, the pixel addressing and the readout circuits as well as the analogue-to-digital converters are integrated into the chip. These unique characteristics make the CMOS-APS a very compact, low power consumption, photon counting system. The more classical Photon Counting Intensified CCDs (PC-ICCD), the selected CMOS-APS, the driving and interface electronics based on Field Programmable Gate Array (FPGA), and the adopted algorithm to compute the center of the luminous spot on the MCP phosphor screen are described.

  18. An AP4B1 frameshift mutation in siblings with intellectual disability and spastic tetraplegia further delineates the AP-4 deficiency syndrome.

    PubMed

    Abdollahpour, Hengameh; Alawi, Malik; Kortüm, Fanny; Beckstette, Michael; Seemanova, Eva; Komárek, Vladimír; Rosenberger, Georg; Kutsche, Kerstin

    2015-02-01

    The recently proposed adaptor protein 4 (AP-4) deficiency syndrome comprises a group of congenital neurological disorders characterized by severe intellectual disability (ID), delayed or absent speech, hereditary spastic paraplegia, and growth retardation. AP-4 is a heterotetrameric protein complex with important functions in vesicle trafficking. Mutations in genes affecting different subunits of AP-4, including AP4B1, AP4E1, AP4S1, and AP4M1, have been reported in patients with the AP-4 deficiency phenotype. We describe two siblings from a non-consanguineous couple who presented with severe ID, absent speech, microcephaly, growth retardation, and progressive spastic tetraplegia. Whole-exome sequencing in the two patients identified the novel homozygous 2-bp deletion c.1160_1161delCA (p.(Thr387Argfs*30)) in AP4B1. Sanger sequencing confirmed the mutation in the siblings and revealed it in the heterozygous state in both parents. The AP4B1-associated phenotype has previously been assigned to spastic paraplegia-47. Identification of a novel AP4B1 alteration in two patients with clinical manifestations highly similar to other individuals with mutations affecting one of the four AP-4 subunits further supports the observation that loss of AP-4 assembly or functionality underlies the common clinical features in these patients and underscores the existence of the clinically recognizable AP-4 deficiency syndrome. PMID:24781758

  19. Simultaneous recording of t-tubular electrical activity and Ca2+-release in heart failure

    NASA Astrophysics Data System (ADS)

    Crocini, C.; Coppini, R.; Ferrantini, C.; Yan, P.; Loew, L.; Tesi, C.; Poggesi, C.; Cerbai, E.; Pavone, F. S.; Sacconi, L.

    2014-05-01

    T-tubules (TT) are invaginations of the surface sarcolemma (SS) that mediate the rapid propagation of the action potential (AP) to the cardiomyocyte core. We employed the advantages of an ultrafast random access multi-photon (RAMP) microscope (Sacconi et al., PNAS 2012) with a double staining approach to optically record t-tubular AP and, simultaneously, the corresponding local Ca2+-release in different positions across the cardiomyocytes. Despite a uniform AP between SS and TT at steady-state stimulation, in control cardiomyocytes we observed a non-negligible be variability of local Ca2+-transient amplitude and kinetics. This variability was significantly reduced by applying 0.1?M Isoproterenol, which increases the opening probability of Ca2+-release units. In the rat heart failure model (HF), we previously demonstrated that some tubular elements fail to propagate AP. We found that the tubules unable to propagate AP, displayed a reduced correspondent Ca2+-transient amplitude as well as a slower Ca2+ rise compared to electrically coupled tubules. Moreover variability of Ca2+-transient kinetics were increased in HF. Finally, TT that did not show AP, occasionally exhibited spontaneous depolarizations that were never accompanied by local Ca2+-release in the absence of any pro-arrhythmogenic stimulation. Simultaneous recording of AP and Ca2+-transient allows us to probe the spatio-temporal variability of Ca2+-release, whereas the investigation of Ca2+-transient in HF discloses an unexpected uncoupling between t-tubular depolarization and Ca2+-release in remodeled tubules. This work was funded by the European Union 7th Framework Program (FP7/2007- 2013) under grant agreement n° 284464, 241526, by the Italian Ministry of University and Research (NANOMAX), and by Telethon-Italy (GGP13162).

  20. Pyrometry in the Multianvil Press: New approach for temperature measurement in large volume press experiments

    NASA Astrophysics Data System (ADS)

    Sanehira, T.; Wang, Y.; Prakapenka, V.; Rivers, M. L.

    2008-12-01

    Temperature measurement in large volume press experiments has been based on thermocouple emf, which has well known problems: unknown pressure dependence of emf [e.g., 1], chemical reaction between thermocouple and other materials, deformation related texture development in the thermocouple wires [2], and so on. Thus, different techniques to measure temperatures in large volume press experiments other than thermocouples are required to measure accurate temperatures under high pressures. Here we report a new development using pyrometry in the multianvil press, where temperatures are derived on the basis of spectral radiometry. Several high pressure runs were conducted using the 1000 ton press with a DIA module installed at 13 ID-D GSECARS beamline at Advanced Photon Source (APS) [3]. The cubic pressure medium, 14 mm edge length, was made of soft-fired pyrophyllite with a graphite furnace. A moissanite (SiC) single crystal was built inside the pressure medium as a window for the thermal emission signal to go through. An MgO disk with 1.0 mm thickness was inserted in a gap between the top of the SiC crystal and thermocouple hot junction. The bottom of the window crystal was in direct contact with the tip of the anvil, which had a 1.5 mm diameter hole drilled all the way through the anvil axis. An optical fiber was inserted in this hole and the open end of fiber was in contact with the SiC crystal. Thermal spectral radiance from the inner cell assembly was obtained via the fiber and recorded by an Ocean Optics HP2000 spectrometer. The system response of spectrometer was calibrated by a tungsten ribbon ramp (OL550S, Optronic Laboratories, Inc.) with standard of spectral radiance. The cell assembly was compressed up to target value of 15 tons and then temperature was increased up to 1573 K. Radiation spectra were mainly obtained above 873 K and typical integration time was 1 ms or 10 ms. Data collection was done in the process of increase and decrease of temperature. In one in-situ X-ray experiment, pressures near the thermocouple were derived from the equations of state for gold [4] or MgO [5], and the pressure values varied up to approximately 1 GPa at various temperatures. Two different calculations were made to infer temperature based on pyrometry. One was made based on Planck radiation function and the other was made by the J-function, which was defined based on the law of Wien [6]. Calculated temperatures above about 1000 K were generally consistent with those obtained from the thermocouple emf. However, below about 1000 K, temperatures based on pyrometry in the process of increase of temperature were way off from those obtained by thermocouple emf. Recent results and future improvements will be discussed. Reference [1] I. C. Getting and G. C. Kennedy J. Appl. Phys., 41, 4552-4562, 1970. [2] J. Li, C. Hadidiacos, H.-K. Mao, Y. Fei and R. J. Hemley High Pressure Research, 23, 389-401, 2003. [3] Y. Wang, M. Rivers, S. Sutton, N. Nishiyama, T. Uchida, T. Sanehira Phys. Earth Planet. Inter. in press. [4] S.-H. Shim, T. S. Duffy and K. Takemura Earth Planet. Sci. Lett., 203, 729-739, 2002. [5] M. Matsui, S. C. Parker and M. Leslie Am. Mineral., 85, 312-316, 2000. [6] T. Yagi and J. Susaki, in High-Pressure Research: Application to Earth and Planetary Sciences, edited by Y. Syono and M. H. Manghnani, pp.51-54, TERRAPUB, Tokyo / AGU, Washington D.C., 1992.

  1. QCD on the Massively Parallel Computer AP1000

    NASA Astrophysics Data System (ADS)

    Akemi, K.; Fujisaki, M.; Okuda, M.; Tago, Y.; Hashimoto, T.; Hioki, S.; Miyamura, O.; Takaishi, T.; Nakamura, A.; de Forcrand, Ph.; Hege, C.; Stamatescu, I. O.

    We present the QCD-TARO program of calculations which uses the parallel computer AP1000 of Fujitsu. We discuss the results on scaling, correlation times and hadronic spectrum, some aspects of the implementation and the future prospects.

  2. Ap ery's Double Sum is Plain Sailing Indeed Carsten Schneider

    E-print Network

    Schneider, Carsten

    Ap#19;ery's Double Sum is Plain Sailing Indeed Carsten Schneider #3; Research Institute the summation package Sigma [6] we get plain sailing { instead of plane sailing, cf. van der Poorten's statement

  3. Engaging Cuban Physicists Through the APS/CPS Partnership

    NASA Astrophysics Data System (ADS)

    Lerch, Irving A.; Lerch, Irving A.

    In his reflections on Cuban physics, Marcelo Alonso urges APS to take steps to promote interactions between Cuban and US physicists. As an introduction to Marcello's essay, this note will summarize past and current activities.

  4. APS1005: Operations Research for Engineering Management Summer 2015

    E-print Network

    Toronto, University of

    APS1005: Operations Research for Engineering Management Summer 2015 Lecturer: Daniel Frances, optimal control, production planning, reliability engineering, and operations management. The contents applicable in solving various engineering problems. These techniques are widely used in engineering design

  5. APS/DPP 111207-se 1 University Fusion Association Meeting

    E-print Network

    APS/DPP 111207-se 1 University Fusion Association Meeting Orlando, FL November 12, 2007 Stephen.ofes.fusion.doe.gov U.S. Department of Energy's Office of Science #12;APS/DPP 111207-se 2 Topics · Budget status/DPP 111207-se 3 FY 2008 Fusion Energy Sciences Congressional Budget Request 144.6 146.3 20.8 311.7 FY 2007

  6. Observing roAp Stars with WET: A Primer

    NASA Astrophysics Data System (ADS)

    Kurtz, D. W.; Martinez, P.

    We give an extensive primer on roAp stars -- introducing them, putting them in context and explaining terminology and jargon, and giving a thorough discussion of what is known and not known about them. This provides a good understanding of the kind of science WET could extract from these stars. We also discuss the many potential pitfalls and problems in high-precision photometry. Finally, we suggest a WET campaign for the roAp star HR 1217.

  7. Minghui Hu, et al., Journal of Catalysis in press Page 1 of 25

    E-print Network

    Maruyama, Shigeo

    during reduction, and Mo carbides release active carbon to catalytic metallic Co particles from whichMinghui Hu, et al., Journal of Catalysis in press Page 1 of 25 Morphology and chemical state of Co-Mo catalysts for growth of single-walled carbon nanotubes vertically aligned on quartz substrates Minghui Hu

  8. The (Very) Slow Rotation of Magnetic Ap Stars

    NASA Astrophysics Data System (ADS)

    Mathys, Gautier

    2015-08-01

    To this date, 34 magnetic Ap stars that have periods of variation longer than 30 days are known. They represent a considerable fraction of the total number of Ap stars whose period has been reliably determined. All the available evidence unambiguously indicates that the observed variations of those long-period Ap stars result from the changing aspect of their visible hemisphere as they rotate, thus that the oblique rotator model is applicable throughout the whole range of periods of variation of the Ap stars. We show that the periods of the most slowly rotating Ap stars must be of the order of 300 years, and that some may even be longer, possibly up to 1000 years. The 5 to 6 orders of magnitude spanned by the rotation periods of the Ap stars present a major challenge for the understanding of their origin and their evolution. To guide the theo- retical developments, observational hints may be found in possible differences between the magnetic properties of stars that have rotation periods in different ranges. Such differences are starting to emerge from the existing data. To increase their significance level, study of the longest-period stars must be continued over their full rotation cycle. Failure to secure observations now may leave critical data missing for several decades, or even centuries.

  9. Chemical composition and fundamental parameters of roAp stars

    E-print Network

    M. J. Gelbmann

    1998-05-05

    Element abundances of three roAp stars, HD 166473, HD 203932, and HD 217522, were determined using Kurucz model atmospheres with metal abundances scaled to solar ones and the results were compared with data from the literature concerning three further roAp stars, normal B and A stars and two lambda Bootis stars. Up to 38 elements could be identified and therefore, this work represents the most complete chemical investigation hitherto published, which can be summarized as follows: - all investigated roAp stars have a similar abundance pattern, - the overabundances of rare earth and other heavy elements are comparable to cool non-pulsating Ap-stars, - iron belongs to the most deficient and cobalt to the most enhanced elements in the group of the iron peak elements, and - the light elements carbon, nitrogen, and oxygen are less abundant than in atmospheres with abundances scaled to the Sun. Beside an unexpected possible relation between effective temperature and metallicity of roAp stars, no outstanding differences from non-pulsating Ap stars could be detected. This statement, however, suffers from the lack of comparably detailed investigations of the latter.

  10. AP® Potential Predicted by PSAT/NMSQT® Scores Using Logistic Regression. Statistical Report 2014-1

    ERIC Educational Resources Information Center

    Zhang, Xiuyuan; Patel, Priyank; Ewing, Maureen

    2014-01-01

    AP Potential™ is an educational guidance tool that uses PSAT/NMSQT® scores to identify students who have the potential to do well on one or more Advanced Placement® (AP®) Exams. Students identified as having AP potential, perhaps students who would not have been otherwise identified, should consider enrolling in the corresponding AP course if they…

  11. Improving Dryer and Press Efficiencies Through Combustion of Hydrocarbon Emissions

    SciTech Connect

    Sujit Banerjee

    2005-10-31

    Emission control devices on dryers and presses have been legislated into the industry, and are now an integral part of the drying system. These devices consume large quantities of natural gas and electricity and down-sizing or eliminating them will provide major energy savings. The principal strategy taken here focuses on developing process changes that should minimize (and in some cases eliminate) the need for controls. A second approach is to develop lower-cost control options. It has been shown in laboratory and full-scale work that Hazardous Air Pollutants (HAPs) emerge mainly at the end of the press cycle for particleboard, and, by extension, to other prod-ucts. Hence, only the air associated with this point of the cycle need be captured and treated. A model for estimating terpene emissions in the various zones of veneer dryers has been developed. This should allow the emissions to be concentrated in some zones and minimized in others, so that some of the air could be directly released without controls. Low-cost catalysts have been developed for controlling HAPs from dryers and presses. Catalysts conventionally used for regenerative catalytic oxidizers can be used at much lower temperatures for treating press emissions. Fluidized wood ash is an especially inexpensive mate-rial for efficiently reducing formaldehyde in dryer emissions. A heat transfer model for estimating pinene emissions from hot-pressing strand for the manufacture of flakeboard has been constructed from first principles and validated. The model shows that most of the emissions originate from the 1-mm layer of wood adjoining the platen surface. Hence, a simple control option is to surface a softwood mat with a layer of hardwood prior to pressing. Fines release a disproportionate large quantity of HAPs, and it has been shown both theo-retically and in full-scale work that particles smaller than 400 ���µm are principally responsible. Georgia-Pacific is considering green-screening their furnish at several of their mills in order to remove these particles and reduce their treatment costs.

  12. Influence of Volume Deformation Rate on the Intensity of Oil-Bearing Crop Pressing-out in Relation to Rape Extrudate

    NASA Astrophysics Data System (ADS)

    Slavnov, E. V.; Petrov, I. A.

    2015-07-01

    The influence of the volume deformation rate on the intensity of piston pressing-out of oil has been investigated. The results of pressing by a piston moving with different speeds are presented. Mathematical simulation is carried out for the stage of pressing-out after the termination of sample loading, when oil release occurs due to the accumulated deformations of the skeleton. It has been assumed that in mechanical pressing there remains the least residual content of oil. A dimensionless complex representing the ratio of the characteristic times of loading to the material response (the process of pressing) has been obtained. The dependence of the rate of oil pressing-out at the stage of pressure relaxation on the dimensionless complex has been determined.

  13. Spatial distribution and compositional variation of APS minerals related to uranium deposits in the Kiggavik-Andrew Lake structural trend, Nunavut, Canada

    NASA Astrophysics Data System (ADS)

    Riegler, Thomas; Quirt, Dave; Beaufort, Daniel

    2015-07-01

    The Kiggavik-Andrew Lake structural trend consists of four mineralized zones, partially outcropping, lying 2 km south of the erosional contact with the unmetamorphosed sandstone and basal conglomerates of the Paleoproterozoic Thelon Formation. The mineralization is controlled by a major E-W fault system associated with illite and sudoite alteration halos developed in the Archean metagraywackes of the Woodburn Lake Group. Aluminum phosphate sulfate (APS) minerals from the alunite group crystallized in association with the clay minerals in the basement alteration halo as well as in the overlying sandstones, which underwent mostly diagenesis. APS minerals are Sr- and S-rich (svanbergite end-member) in the sedimentary cover overlying the unconformity, whereas they are light rare earth elements (LREE)-rich (florencite end-member) in the altered basement rocks below the unconformity. The geochemical signature of each group of APS minerals together with the petrography indicates three distinct generations of APS minerals related to the following: (1) paleoweathering of continental surfaces prior to the basin occurrence, (2) diagenetic processes during the burial history of the lower unit of the Thelon sandstones, and (3) hydrothermal alteration processes which accompanied the uranium deposition in the basement rocks and partially overlap the sedimentary-diagenetic mineral parageneses. In addition, the association of a first generation of APS minerals with both detrital cerium oxide and aluminum oxy-hydroxide highlights the fact that a part of the detrital material of the basal Thelon Formation originated from eroded paleolaterite (allochthonous regolith). The primary rare earth element (REE)-bearing minerals (e.g., monazite, REE carbonates, and allanite) of the host rocks were characterized to identify the potential sources of REE. The REE chemical composition highlights a local re-incorporation of the REE released from the alteration processes in the APS minerals of hydrothermal origin. The distinctive geochemical signatures between diagenetic (or sedimentary) and hydrothermal APS minerals suggest a different source material in the Thelon basin than in the Athabasca basin.

  14. 7 CFR 58.421 - Press.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...and Grading Service 1 Equipment and Utensils § 58.421 Press. The cheese press should be constructed of stainless steel and all joints welded and all surfaces, seams and openings readily cleanable. The pressure device shall be the...

  15. DESIGN AND OPERATION OF BELT FILTER PRESSES

    EPA Science Inventory

    Because early models of belt filter presses (developed from technology associated with the manufacture of paper) performed poorly, improved design and operation procedures for these presses were studied. Belt filter presses form part of a sludge dewatering system, and in terms of...

  16. UNIVERSITY OF CHICAGO PRESS Permission Department

    E-print Network

    Mateo, Jill M.

    UNIVERSITY OF CHICAGO PRESS Permission Department 1427 E. 60th Street Chicago, Illinois 60637 Fax of Chicago Press Material Thank you for your interest in republishing material from the University of Chicago material copyrighted by the University of Chicago Press [complete for each publication you wish to use

  17. Apollo 13 Facts: Press Conference

    NASA Technical Reports Server (NTRS)

    2001-01-01

    Flight Director Gene Krantz gives an overview of the Apollo 13 mission as corrections are made in the power down checklist, passive thermal control, and orbital burns after the spacecraft runs into problems. He then answers questions from the press with the help of Tony England, Bill Peters, and Dick Thorson. Footage then shows newspaper headlines 'We're Not Concerned' and 'Getting Ready to Land' as people watch televisions to see if the astronauts landed safely. The press conference section of this video has sound, the headlines section does not.

  18. The AP-1 transcription factor homolog Pf-AP-1 activates transcription of multiple biomineral proteins and potentially participates in Pinctada fucata biomineralization

    PubMed Central

    Zheng, Xiangnan; Cheng, Minzhang; Xiang, Liang; Liang, Jian; Xie, Liping; Zhang, Rongqing

    2015-01-01

    Activator protein-1 (AP-1) is an important bZIP transcription factor that regulates a series of physiological processes by specifically activating transcription of several genes, and one of its well-chartered functions in mammals is participating in bone mineralization. We isolated and cloned the complete cDNA of a Jun/AP-1 homolog from Pinctada fucata and called it Pf-AP-1. Pf-AP-1 had a highly conserved bZIP region and phosphorylation sites compared with those from mammals. A tissue distribution analysis showed that Pf-AP-1 was ubiquitously expressed in P. fucata and the mRNA level of Pf-AP-1 is extremely high in mantle. Pf-AP-1 expression was positively associated with multiple biomineral proteins in the mantle. The luciferase reporter assay in a mammalian cell line showed that Pf-AP-1 significantly up-regulates the transcriptional activity of the promoters of KRMP, Pearlin, and Prisilkin39. Inhibiting the activity of Pf-AP-1 depressed the expression of multiple matrix proteins. Pf-AP-1 showed a unique expression pattern during shell regeneration and pearl sac development, which was similar to the pattern observed for biomineral proteins. These results suggest that the Pf-AP-1 AP-1 homolog is an important transcription factor that regulates transcription of several biomineral proteins simultaneously and plays a role in P. fucata biomineralization, particularly during pearl and shell formation. PMID:26404494

  19. Impact Fragmentation and Ballistics of Pressed Aluminum Powder Projectiles

    NASA Astrophysics Data System (ADS)

    Thuot, S. C.; Wilkinson, J.; Lee, R. J.; Carney, J. R.; Hooper, J.; Lightstone, J. M.; Jouet, J. R.; Rogerson, J. G.

    2009-12-01

    The penetration and fragmentation characteristics of spheres made of pressed aluminum powder are studied via normal impact on thin steel plates at 0.6 to 1.8 km/s. Ultra-high speed photography and flash x-rays are used to monitor the formation and evolution of the debris cloud formed by impact. The mass distribution of debris fragments is measured directly via a soft-catch experiment. Experimental results are compared to simple analytic theories of brittle fragmentation and spall. This data aids in understanding the mechanical properties and potential energy release of porous reactive materials.

  20. Validation of the new trapped environment AE9/AP9/SPM at low Earth orbit

    NASA Astrophysics Data System (ADS)

    Badavi, Francis F.

    2014-09-01

    The completion of the international space station (ISS) in 2011 has provided the space research community an ideal proving ground for future long duration human activities in space. Ionizing radiation measurements in ISS form the ideal tool for the validation of radiation environmental models, nuclear transport codes and nuclear reaction cross sections. Indeed, prior measurements on the space transportation system (STS; shuttle) provided vital information impacting both the environmental models and the nuclear transport code developments by indicating the need for an improved dynamic model of the low Earth orbit (LEO) trapped environment. Additional studies using thermo-luminescent detector (TLD), tissue equivalent proportional counter (TEPC) area monitors, and computer aided design (CAD) model of earlier ISS configurations, confirmed STS observations that, as input, computational dosimetry requires an environmental model with dynamic and directional (anisotropic) behavior, as well as an accurate six degree of freedom (DOF) definition of the vehicle attitude and orientation along the orbit of ISS. At LEO, a vehicle encounters exposure from trapped particles and attenuated galactic cosmic rays (GCR). Within the trapped field, a challenge arises from properly estimating the amount of exposure acquired. There exist a number of models to define the intensities of the trapped particles during the solar quiet and active times. At active times, solar energetic particles (SEP) generated by solar flare or coronal mass ejection (CME) also contribute to the exposure at high northern and southern latitudes. Among the more established trapped models are the historic and popular AE8/AP8, dating back to the 1980s, the historic and less popular CRRES electron/proton, dating back to 1990s and the recently released AE9/AP9/SPM. The AE9/AP9/SPM model is a major improvement over the older AE8/AP8 and CRRES models. This model is derived from numerous measurements acquired over four solar cycles dating back to the 1970s, roughly representing 40 years of data collection. In contrast, the older AE8/AP8 and CRRES models were limited to only a few months of measurements taken during the prior solar minima and maxima. The dual goal of this paper is to first validate the AE8/AP8 and AE9/AP9/SPM trapped models against ISS dosemetric measurements for a silicon based detector, to assess the improvements in the AE9/AP9/SPM model as compared to AE8/AP8 model. The validation is done at selected target points within ISS-6A configuration during its passage through the south Atlantic anomaly (SAA). For such validation, only the isotropic spectrum of either model is needed. As a second goal, the isotropic spectra of both trapped models are re-casted into anisotropic spectra by modulating them with a measurement derived angular formalism which is applicable to trapped protons. Since at LEO electrons have minimal exposure contribution, the paper ignores the AE8 and AE9 component of the models and presents the angular validation of AP8 and AP9 against measurements from the compact environment anomaly sensor (CEASE) science instrument package, flown onboard the tri-service experiment-5 (TSX-5) satellite during the period of June 2000-July 2006. The spin stabilized satellite was flown in a 410 × 1710 km, 69° inclination orbit, allowing it to be exposed to a broad range of LEO regime. Particular emphasize is put on the validation of proton flux profiles at differential 40 MeV and integral >40 MeV, in the vicinity of SAA where protons exhibit east-west (EW) anisotropy and have a relatively narrow pitch angle distribution. Within SAA, the EW anisotropy results in different level of exposure to each side of CEASE instrument package, allowing the extraction of anisotropic proton spectra from the measurements. While the magnitude of the EW effect at LEO depends on a multitude of factors such as trapped proton energy, orientation of the spacecraft along the velocity vector and altitude of the spacecraft, for this part, the paper draws quantitative conclusions on t

  1. THE VALUE OF PHYSICS (My election statement for APS)

    E-print Network

    Gardel, Margaret

    . In some places, government labs are pressed into being mouthpieces of partisan policy or politics fabrication scandals at Bell Labs and Lawrence Berkeley have proven destructive, particularly so because

  2. EPICS Input/Output Controller (IOC) application developer`s guide. APS Release 3.12

    SciTech Connect

    Kraimer, M.R.

    1994-11-01

    This document describes the core software that resides in an Input/Output Controller (IOC), one of the major components of EPICS. The basic components are: (OPI) Operator Interface; this is a UNIX based workstation which can run various EPICS tools; (IOC) Input/Output Controller; this is a VME/VXI based chassis containing a Motorola 68xxx processor, various I/O modules, and VME modules that provide access to other I/O buses such as GPIB, (LAN), Local Area Network; and this is the communication network which allows the IOCs and OPIs to communicate. Epics provides a software component, Channel Access, which provides network transparent communication between a Channel Access client and an arbitrary number of Channel Access servers.

  3. The fundamental parameters of the Ap star 78 Virginis. Could 78 Vir be a rapidly oscillating Ap star?

    NASA Astrophysics Data System (ADS)

    Perraut, K.; Cunha, M.; Brandão, I.; Loridat, J.; Mourard, D.; Meilland, A.; Nardetto, N.; McAlister, H.; ten Brummelaar, T. A.; Sturmann, J.; Sturmann, L.; Turner, N.; Farrington, C.; Vargas, N.

    2015-07-01

    Context. Determining the effective temperature of Ap stars, including the roAp stellar pulsators, is a difficult task owing to their strong magnetic field and their related spotted surfaces. It is, however, an important step towards constraining models of their complex atmosphere and testing proposed pulsation excitation mechanisms. Aims: Using the unique angular resolution provided by long-baseline visible interferometry, we aim at deriving accurate angular diameters of a number of Ap targets, so as to determine their unbiased effective temperature (Teff) and their accurate position in the Hertzsprung-Russell diagram, to estimate their mass and age, and to test non-adiabatic pulsation models. Interferometric results on four Ap stars have been published in earlier works. Here we report the results on a fifth, significantly hotter star. Methods: We observed 78 Vir with the visible spectrograph VEGA installed at the combined focus of the CHARA long-baseline optical array. We derived the limb-darkened diameter of this Ap star from our interferometric measurements. Based on photometric and spectroscopic data available in the literature, we estimated the star's bolometric flux and used it, in combination with its parallax and angular diameter, to determine the star's luminosity and effective temperature. We then used the derived fundamental parameters to perform a non-adiabatic pulsation analysis. Results: We determined a limb-darkened angular diameter of 0.346 ± 0.006 mas and deduced a linear radius of R = 2.11 ± 0.04 R?. Considering a bolometric flux of 2.73 ± 0.20 10-7 erg/cm2/s we obtained a luminosity of L/L? = 27 ± 2 and an effective temperature of Teff = 9100 ± 190 K. The non-adiabatic pulsation modeling allows us to predict that high overtone pulsations could be excited in 78 Vir at frequencies ranging from 1.2 to 1.9 mHz, provided that the magnetic field is capable of suppressing envelope convection in the polar regions. Conclusions: Visible long-baseline interferometry is a unique means of deriving accurate fundamental parameters of Ap stars. The Ap star 78 Vir is found to be a promising roAp-star candidate and one that would allow us to extend recent tests on the roAp stars' excitation mechanism towards the blue edge of the instability strip. Asteroseismic data of this star would, therefore, be of strong interest. Based on observations made with the VEGA/CHARA spectro-interferometer.

  4. Ground vibration model studies for APS storage ring

    SciTech Connect

    Koul, R.K.

    1994-07-01

    An analytical ground vibration model is developed for study of the vibration effects on the beam motion in the Advanced Photon Source (APS) storage ring. The different physical parameters associated with the wave characteristics and the vibration modes needed for the study are taken from the vibration studies carried out at the APS site. The implementation has been carried out using Mathematica{trademark}. The study is carried out for the frequency range 1--35 Hz, with a number of sources changing from one through ten. The program written in Mathematica{trademark}, calculates orbit distortion, beta wave change, tune change, dispersion change, and chromaticity change. However, the main parameter studied for the APS storage ring has been the orbit distortion. The merit factor associated with different modes excited by the vibrations has been calculated.

  5. NATIONAL ACADEMY PRESS WEB SITE

    EPA Science Inventory

    The National Academy Press is the publisher for the National Academy of Sciences, the National Academy of Engineering, the Institute of Medicine, and the National Research Council. Through this web site, you have access to a virtual treasure trove of books, reports and publicatio...

  6. Gifted Education Press Quarterly, 1995.

    ERIC Educational Resources Information Center

    Fisher, Maurice D., Ed.

    1995-01-01

    This document consists of the four issues of the newsletter "Gifted Education Press Quarterly" published during 1995. This newsletter addresses issues in the education of gifted children and youth. The major articles are: (1) "Using Today's Technology: Parents Can Help Challenge Gifted Children" (Adrienne O'Neill); (2) "Outcomes-Based Education…

  7. Israel Studies Brandeis University Press

    E-print Network

    Snider, Barry B.

    Israel Studies Brandeis University Press #12;1 800-421-1561 · www.upne.com/brandeis.html BRANDEIS in Israel Studies Israel A History anita shapira Now in Paperback Written by one of Israel's most notable scholars, this volume provides a breathtaking history of Israel from the origins of the Zionist movement

  8. Book Editors IOS Press, 2006

    E-print Network

    Zell, Andreas

    in- sensitive to changes in viewpoint. There are two considerations when using local features [5 changes. While point localization and signature aspects of interest point algorithms are often designedBook Title Book Editors IOS Press, 2006 1 Appearance-based Localization of Mobile Robots using

  9. Piping benchmark problems for the Westinghouse AP600 Standardized Plant

    SciTech Connect

    Bezler, P.; DeGrassi, G.; Braverman, J.; Wang, Y.K.

    1997-01-01

    To satisfy the need for verification of the computer programs and modeling techniques that will be used to perform the final piping analyses for the Westinghouse AP600 Standardized Plant, three benchmark problems were developed. The problems are representative piping systems subjected to representative dynamic loads with solutions developed using the methods being proposed for analysis for the AP600 standard design. It will be required that the combined license licensees demonstrate that their solutions to these problems are in agreement with the benchmark problem set.

  10. AP39, A Mitochondrially Targeted Hydrogen Sulfide Donor, Exerts Protective Effects in Renal Epithelial Cells Subjected to Oxidative Stress in Vitro and in Acute Renal Injury in Vivo.

    PubMed

    Ahmad, Akbar; Olah, Gabor; Szczesny, Bartosz; Wood, Mark E; Whiteman, Matthew; Szabo, Csaba

    2016-01-01

    This study evaluated the effects of AP39 [(10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5yl) phenoxy)decyl) triphenyl phosphonium bromide], a mitochondrially targeted donor of hydrogen sulfide (H2S) in an in vitro model of hypoxia/oxidative stress injury in NRK-49F rat kidney epithelial cells (NRK cells) and in a rat model of renal ischemia-reperfusion injury. Renal oxidative stress was induced by the addition of glucose oxidase, which generates hydrogen peroxide in the culture medium at a constant rate. Glucose oxidase (GOx)-induced oxidative stress led to mitochondrial dysfunction, decreased intracellular ATP content, and, at higher concentrations, increased intracellular oxidant formation (estimated by the fluorescent probe 2, 7-dichlorofluorescein, DCF) and promoted necrosis (estimated by the measurement of lactate dehydrogenase release into the medium) of the NRK cells in vitro. Pretreatment with AP39 (30-300?nM) exerted a concentration-dependent protective effect against all of the above effects of GOx. Most of the effects of AP39 followed a bell-shaped concentration-response curve; at the highest concentration of GOx tested, AP39 was no longer able to afford cytoprotective effects. Rats subjected to renal ischemia/reperfusion responded with a marked increase (over four-fold over sham control baseline) blood urea nitrogen and creatinine levels in blood, indicative of significant renal damage. This was associated with increased neutrophil infiltration into the kidneys (assessed by the myeloperoxidase assay in kidney homogenates), increased oxidative stress (assessed by the malondialdehyde assay in kidney homogenates), and an increase in plasma levels of IL-12. Pretreatment with AP39 (0.1, 0.2, and 0.3?mg/kg) provided a dose-dependent protection against these pathophysiological alterations; the most pronounced protective effect was observed at the 0.3?mg/kg dose of the H2S donor; nevertheless, AP39 failed to achieve a complete normalization of any of the injury markers measured. The partial protective effects of AP39 correlated with a partial improvement of kidney histological scores and reduced TUNEL staining (an indicator of DNA damage and apoptosis). In summary, the mitochondria-targeted H2S donor AP39 exerted dose-dependent protective effects against renal epithelial cell injury in vitro and renal ischemia-reperfusion injury in vivo. We hypothesize that the beneficial actions of AP39 are related to the reduction of cellular oxidative stress, and subsequent attenuation of various positive feed-forward cycles of inflammatory and oxidative processes. PMID:26513708

  11. Exploring Mars: The Ares Payload Service (APS)

    NASA Astrophysics Data System (ADS)

    Bowen, Justin; Lusignan, Bruce

    1999-08-01

    In last year's Mars Society convention we introduced the results of five years of studies of space launch capability for the second millennium. We concluded that Single Stage to Orbit (SSTO) vehicles such as the Delta Clipper X33, and X34 cannot make it to orbit from the Earth's surface. Whether taking off vertically or horizontally or landing vertically or horizontally, the rocket equations, the performance of available fuels, and the realities of the weight and strength of materials leave no margin for payload. The promised savings from SSTO systems are illusory. However, a configuration that is able to deliver useful payload to orbit is the Single step to Orbit, SsTO, a rocket plane that is released fully fueled, from 35,000 to 40,000 feet altitude. Three approaches have been proposed. The Hot'l and Molnya Corporation designs carry the fueled rocket plane to altitude on the back of a carrier aircraft. In this design the carrier aircraft is Russia's Antonov 225 the world's largest cargo plane. The rocket plane is a modified version of the Buran, Russia's own space shuttle. Another configuration is Kelly Aviation's concept in which the fully fueled rocket plane is towed to altitude by the cargo plane and then released. A third approach is based on the early "X" planes, which were dropped from the belly of the carrier plane. While the rocket equations indicate that these three concepts can deliver useful payloads, the Stanford review found significant advantages to the approach of Pioneer Rocket, in which the rocket plane flies up to the carrier plane with conventional jet engines, docks, and then loads on the oxidizer for the flight to orbit. This architecture has more reasonable abort modes in case of system failure in either aircraft and can deliver a larger final payload to orbit for a given sized carrier. The Stanford recommendation is that the carrier aircraft be the Antonov 225. A design based on this was presented in a report last year. Refinements to the design notably an improved re-entry cooling system and fueling stability analysis were done this year. More technical detail and a proposed international consortium to develop the SSTO is presented in another session of this year's Mars convention. We believe that there will be no human exploration of Mars based on the Shuttle or Expendable launch vehicles, and no resources available except for a cooperative international program. However, just as the world is learning to cooperate in peacekeeping, we hold out the hope that similar cooperation will develop for Mars exploration. With that in mind, this year we asked the question- "How will the human mission get to Mars if it has to use the SsTO for transportation?"

  12. Exploring Mars: the Ares Payload Service (APS)

    NASA Technical Reports Server (NTRS)

    Bowen, Justin; Lusignan, Bruce

    1999-01-01

    In last year's Mars Society convention we introduced the results of five years of studies of space launch capability for the second millennium. We concluded that Single Stage to Orbit (SSTO) vehicles such as the Delta Clipper X33, and X34 cannot make it to orbit from the Earth's surface. Whether taking off vertically or horizontally or landing vertically or horizontally, the rocket equations, the performance of available fuels, and the realities of the weight and strength of materials leave no margin for payload. The promised savings from SSTO systems are illusory. However, a configuration that is able to deliver useful payload to orbit is the Single step to Orbit, SsTO, a rocket plane that is released fully fueled, from 35,000 to 40,000 feet altitude. Three approaches have been proposed. The Hot'l and Molnya Corporation designs carry the fueled rocket plane to altitude on the back of a carrier aircraft. In this design the carrier aircraft is Russia's Antonov 225 the world's largest cargo plane. The rocket plane is a modified version of the Buran, Russia's own space shuttle. Another configuration is Kelly Aviation's concept in which the fully fueled rocket plane is towed to altitude by the cargo plane and then released. A third approach is based on the early "X" planes, which were dropped from the belly of the carrier plane. While the rocket equations indicate that these three concepts can deliver useful payloads, the Stanford review found significant advantages to the approach of Pioneer Rocket, in which the rocket plane flies up to the carrier plane with conventional jet engines, docks, and then loads on the oxidizer for the flight to orbit. This architecture has more reasonable abort modes in case of system failure in either aircraft and can deliver a larger final payload to orbit for a given sized carrier. The Stanford recommendation is that the carrier aircraft be the Antonov 225. A design based on this was presented in a report last year. Refinements to the design notably an improved re-entry cooling system and fueling stability analysis were done this year. More technical detail and a proposed international consortium to develop the SSTO is presented in another session of this year's Mars convention. We believe that there will be no human exploration of Mars based on the Shuttle or Expendable launch vehicles, and no resources available except for a cooperative international program. However, just as the world is learning to cooperate in peacekeeping, we hold out the hope that similar cooperation will develop for Mars exploration. With that in mind, this year we asked the question- "How will the human mission get to Mars if it has to use the SsTO for transportation?"

  13. Spallation of Hot Pressed Boron Carbide Ceramic

    NASA Astrophysics Data System (ADS)

    Bartkowski, Peter T.; Dandekar, Dattatraya P.; Grove, David J.

    2001-06-01

    This work describes the results of plane shock wave spallation experiments conducted on Hot Pressed Boron Carbide marketed by Cercom as PAD B4C (>99of the material was determined to be 2.508 +/-0.016 Mg/m^3 while the longitudinal and shear wave velocities were measured at 13.49 +/-0.18 km/s and 8.65 +/-0.08 km/s, respectively. Spallation thresholds calculated from the measured "pull-back" velocity were determined up to an impact stress of 15.5 GPa. The values of spall threshold do not vary significantly with impact pressure but do exhibit a pulse width dependency indicating a time dependent generation of defects. The value of spall strength of boron carbide is 0.35 +/- 0.07 GPa when shocked between 2 and 15.5 GPa. The values of release impedance lie between 33 and 37 Gg/m^2s and are in good agreement with the longitudinal impedance of 33.8 +/-0.5 Gg/m^2s at the ambient condition measured ultrasonically. The free-surface velocity profiles obtained from these experiments were numerically simulated using Rajendran-Grove (R-G) ceramic model. The paper provides the values of material constants required by the R-G ceramic model for boron carbide.

  14. Spallation of Hot Pressed Boron Carbide Ceramic

    NASA Astrophysics Data System (ADS)

    Bartkowski, Peter T.; Dandekar, Dattatraya P.; Grove, David J.

    2002-07-01

    This work describes the results of plane shock wave spallation experiments conducted on Hot Pressed Boron Carbide marketed by Cercom as PAD B4C (>99% pure). Density of the material was determined to be 2.508 plus-or-minus0.016 Mg/m3 while the longitudinal and shear wave velocities were measured at 13.49 plus-or-minus0.18 km/s and 8.65 plus-or-minus0.08 km/s, respectively. Spallation thresholds calculated from the measured "pull-back" velocity were determined up to an impact stress of 15.5 GPa. The values of spall threshold do not vary significantly with impact pressure but do exhibit a pulse width dependency indicating a time dependent generation of defects. The value of spall strength of boron carbide is 0.35 plus-or-minus 0.07 GPa when shocked between 2 and 15.5 GPa. The values of release impedance lie between 33 and 37 Gg/m2s and are in good agreement with the longitudinal impedance of 33.8 plus-or-minus0.5 Gg/m2s at the ambient condition measured ultrasonically. The free-surface velocity profiles obtained from these experiments were numerically simulated using Rajendran-Grove (R-G) ceramic model. The paper provides the values of material constants required by the R-G ceramic model for boron carbide.

  15. Nuclear Reactor Safety--The APS Submits its Report

    ERIC Educational Resources Information Center

    Physics Today, 1975

    1975-01-01

    Presents the summary section of the American Physical Society (APS) report on the safety features of the light-water reactor, reviews the design, construction, and operation of a reactor and outlines the primary engineered safety features. Summarizes the major recommendations of the study group. (GS)

  16. The AP Course Audit Syllabus Review Process: Methodological Explanation

    ERIC Educational Resources Information Center

    Conley, David T.

    2007-01-01

    The AP Course Audit utilizes a criterion-based professional judgment method of analysis within a nested multi-step review process. The overall goal of the methodology is to yield a final judgment on each syllabus that is ultimately valid. While reviewer consistency is an important consideration, the most important goal is to reach a final judgment…

  17. Approximate entropy (ApEn) as a complexity measure

    NASA Astrophysics Data System (ADS)

    Pincus, Steve

    1995-03-01

    Approximate entropy (ApEn) is a recently developed statistic quantifying regularity and complexity, which appears to have potential application to a wide variety of relatively short (greater than 100 points) and noisy time-series data. The development of ApEn was motivated by data length constraints commonly encountered, e.g., in heart rate, EEG, and endocrine hormone secretion data sets. We describe ApEn implementation and interpretation, indicating its utility to distinguish correlated stochastic processes, and composite deterministic/ stochastic models. We discuss the key technical idea that motivates ApEn, that one need not fully reconstruct an attractor to discriminate in a statistically valid manner—marginal probability distributions often suffice for this purpose. Finally, we discuss why algorithms to compute, e.g., correlation dimension and the Kolmogorov-Sinai (KS) entropy, often work well for true dynamical systems, yet sometimes operationally confound for general models, with the aid of visual representations of reconstructed dynamics for two contrasting processes.

  18. ACTIVATION OF AP-1 IN UROTSA CELLS BY METHYLATED ARSENICALS

    EPA Science Inventory

    ACTIVATION OF AP-1 IN UROTSA CELLS BY METHYLATED TRIVALENT ARSENICALS. Z Drobna1, I Jaspers2, D J Thomas3 and M Styblo1. 1Department of Pediatrics; 2Center for Environmental Medicine and Lung Biology, University of North Carolina at Chapel Hill, NC, USA; 3US EPA, RTP, NC, USA.

  19. 76 FR 82079 - AP1000 Design Certification Amendment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-30

    ... any person. The NRC originally approved the AP1000 design certification in a final rule in 2006 (71 FR... notice of acceptance (ADAMS Accession No. ML073600743) in the Federal Register (73 FR 4926; January 28... applications: . Vogtle, Units 3 and 4......... Docket No. 05200025/6. 73 FR 33118. Bellefonte Nuclear...

  20. 8 | NewScientist | 28 January 2012 RALPHWILSON/AP

    E-print Network

    Jackson, Robert B.

    8 | NewScientist | 28 January 2012 RALPHWILSON/AP Fracking is causing a furore in the US and Europe is scarce DRILLING INTO THE UNKNOWN SPECIALREPORT/FRACKING #12;28 January 2012 | NewScientist | 9 "Neighbours of new fracking operations complain of breathing difficulties and nausea" 100s of metres 1000s

  1. Risks of using AP locations discovered through war driving

    E-print Network

    Kotz, David

    Risks of using AP locations discovered through war driving Minkyong Kim, Jeffrey J. Fielding the actual locations are often unavailable, they use estimated locations from war driving estimated through war driving. War driving is the process of collecting Wi-Fi beacons by driving or walking

  2. AP: A Critical Examination of the Advanced Placement Program

    ERIC Educational Resources Information Center

    Sadler, Philip M., Ed.; Sonnert, Gerhard, Ed.; Tai, Robert H., Ed.; Klopfenstein, Kristin, Ed.

    2010-01-01

    With an annual yearly growth rate of 9.3 percent over the last two decades, Advanced Placement courses have become a juggernaut in American high school education. AP courses are routinely perceived as an indicator of educational rigor, and many schools push to enroll low-income or minority students in these courses in the hope of preparing them…

  3. Characterisation of the AP-3 adaptor-like complex

    E-print Network

    Peden, Andrew Alexander

    2000-02-15

    and the AP-2 complex is associated with the clathrin coated vesicles that bud from the plasma membrane. A new type of adaptor-like complex was discovered in our laboratory and was published in 1996. The complex has been shown to consist of two known proteins...

  4. Status of TRANStatus of TRAN Presented at AP

    E-print Network

    Budny, Robert

    Status of TRANStatus of TRAN Presented at AP NovemberNovember Supported by U.S. DOE Contrac NSP Provide a com d t dend-to-end capability fop y confinement fu experiments oexperiments o tomor Doug Mc and rrow. une 3 #12;Traditional TRATraditional TRA Experiments (Asdex-U, C-Mo ITER, JET, MAST, NSTX, H

  5. 75 FR 75666 - Advanced Placement (AP) Test Fee Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-06

    ...: On September 1, 2010, we published in the Federal Register (75 FR 53681) a notice inviting... in the September 1, 2010 notice (75 FR 53682-53683). We encourage eligible applicants to submit their... Advanced Placement (AP) Test Fee Program AGENCY: Office of Elementary and Secondary Education...

  6. Automated Procurement System (APS) revised project management plan (DS-03)

    NASA Technical Reports Server (NTRS)

    Murphy, Diane R.

    1995-01-01

    The Project Plan is the governing document for the implementation of the Automated Procurement System (APS). It includes a description of the proposed system, describes the work to be done, establishes a schedule of deliverables, and discusses the major standards and procedures to be followed.

  7. Tank 241AP104 Grab Sampling and Analysis Plan

    SciTech Connect

    TEMPLETON, A.M.

    2000-11-09

    This sampling and analysis plan (SAP) identifies characterization objectives pertaining to sample collection, laboratory analytical evaluation, and reporting requirements for samples obtained from tank 241-AP-104. The purpose of this sampling event is to obtain information about the characteristics of the contents of 241-AP-104 required to provide sample material to the Waste Treatment Contractor. Grab samples will be obtained from riser 001 to provide sufficient material for the chemical analyses and tests required to satisfy these data quality objectives and ICD-23. The 222-S Laboratory will receive samples; composite the samples; perform chemical analyses on composite samples; and provide samples to the Waste Treatment Contractor and the Process Chemistry Laboratory. The Process Chemistry Laboratory at the 222-S Laboratory Complex will perform process tests to evaluate the behavior of the 241-AP-104 waste undergoing the retrieval and treatment scenarios defined in the applicable DQOs. The Waste Treatment Contractor will perform process verification and waste form qualification tests. Requirements for analyses of samples originating in the L & H DQO process tests will be documented in the corresponding test plan (Person 2000) and are not within the scope of this SAP. This report provides the general methodology and procedures to be used in the preparation, retrieval, transport, analysis, and reporting of results from grab samples retrieved from tank 241-AP-104.

  8. EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH CERNSL2002016 (AP)

    E-print Network

    Keil, Eberhard

    EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH CERN­SL­2002­016 (AP) CLIC Note 511 Monte Carlo (0) and generally be contained within 20-30 radia- tion length (where 0 = 0.56 cm for lead and 0 = 0, the muons do also loose their energy much slower and become the dominant component as far as leakage from

  9. Intermediate-break LOCA analyses for the AP600 design

    SciTech Connect

    Boyack, B.E.; Lime, J.F.

    1995-07-01

    A postulated double-ended guillotine break of a direct-vessel-injection line in an AP600 plant has been analyzed. This event is characterized as an intermediate break loss-of-coolant accident (IBLOCA). Most of the insights regarding the response of the AP600 safety systems to the postulated accident are derived from calculations performed with the TRAC-PFl/MOD2 code. However, complementary insights derived from a scaled experiment conducted in the ROSA facility, as well as insights based upon calculations by other codes, are also presented. The key processes occurring in an AP600 during a IBLOCA are primary coolant system depressurization, inventory depletion, inventory replacement via emergency core coolant injection, continuous core cooling, and long-term decay heat rejection to the atmosphere. Based upon the calculated and experimental results, the AP600 will not experience a core heat up and will reach a safe shutdown state using only safety-class equipment. Only the early part of the long-term cooling period initiated by In-containment Refueling Water Storage Tank injection was evaluated Thus, the observation that the core is continuously cooled should be verified for the latter phase of the long-term cooling period, the interval when sump injection and containment cooling processes are important.

  10. Vibrational Mechanics: Nonlinear Dynamic Effects, General Ap-proach, Applications

    E-print Network

    van der Heijden, Gert

    Review of: Vibrational Mechanics: Nonlinear Dynamic Effects, General Ap- proach, Applications Iliya.H.M. van der Heijden, University College London, UK Fast vibrations may have strong and sometimes unexpected effects on nonlinear mechanical systems. Familiar examples are the stabilisation of the inverted

  11. Integrating Particulate Representations into AP Chemistry and Introductory Chemistry Courses

    ERIC Educational Resources Information Center

    Prilliman, Stephen G.

    2014-01-01

    The College Board's recently revised curriculum for advanced placement (AP) chemistry places a strong emphasis on conceptual understanding, including representations of particle phenomena. This change in emphasis is informed by years of research showing that students could perform algorithmic calculations but not explain those calculations…

  12. 76 FR 10269 - AP1000 Design Certification Amendment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-24

    ... Energy Corporation, EDF-International North America, Inc., Entergy Nuclear, Inc., Exelon Generation...; Bellefonte Nuclear Station, Units 3 and 4, Docket Nos. 05200014/5, 73 FR 4923; Levy County, Units 1 and 2... AP1000 Standard Design,'' in September 2004. From March 2006 through May 2007, NuStart Energy...

  13. Mechanistic studies of the ClpAP protease/

    E-print Network

    Farbman, Mary E

    2008-01-01

    CIpA, a member of the Hspl00/Clp subset of the AAA+ superfamily, is an energy-dependent chaperone, disassembling and remodeling its protein substrates. CIpA also serves as the ATPase component of the ClpAP protease, where ...

  14. A comparison of impulse drying to double felted pressing on pilot- scale shoe presses and roll presses. Progress report, No. 6

    SciTech Connect

    Orloff, D.I.

    1992-08-01

    Pilot-scale shoe press and roll press experiments have been conducted to compare impulse drying and double felted pressing. Both ceramic coated and Beloit Type C press rolls have been evaluated. The experiments show that impulse drying can provide significantly higher outgoing solids than double felled pressing at the same impulse. For example, at an impulse of 0.234 MPa seconds (34 psi seconds), sheets at an ingoing solids of 52% were impulse dried (using the Beloit Type C press roll) to 68% solids while optimized double felled pressing could only yield press dryness of, at most, 60%.

  15. The Dao of human cloning: utopian/dystopian hype in the British press and popular films.

    PubMed

    Jensen, Eric

    2008-04-01

    The issue of human cloning has featured in the national science policy agendas in both the United States and the United Kingdom since the announcement in 1997 of Dolly the cloned sheep's birth in Scotland. Such news stories suggesting the imminent cloning of humans have inspired fictional entertainment media over the years, including numerous popular films. Study 1 examines elite British press coverage of human cloning from 1997 to 2004 (n = 857). Study 2 focuses on five human cloning films released between 1978 and 2003. Two sharply divergent discourses emerged from these data. Unqualified hope and habitually hyped claims of future cures permeated the press discourse. In contrast, the films constructed human cloning as an inherently dangerous technology often wielded by hubristic scientists in the tradition of Frankenstein. Both the predominately positive hype in the broadsheet press and the largely negative hype in the films indicate an impoverished and "thin" public debate on the issue of human cloning. PMID:19391375

  16. AP1000 Features Prevent Potential Containment Recirculation Screen Plugging

    SciTech Connect

    Andreychek, Timothy; Anderson, Richard; Schulz, Terry

    2004-07-01

    This paper presents the results of plant design development and evaluations that demonstrate that the AP1000 plant is not subject to potential containment recirculation screen plugging following a loss-of-coolant-accident (LOCA). Following a LOCA in a pressurized water reactor, it is necessary to recirculate water from the containment back into the reactor to maintain long term core cooling. The AP1000 utilizes passive safety systems to provide containment recirculation for long term core cooling following a LOCA. The AP1000 also has non-safety pumps which provide a backup means of providing recirculation. Screens are provided around the recirculation pipes to prevent debris from blocking recirculation flow and core cooling passages. Debris may be generated by the LOCA blowdown from insulation and coatings used inside containment. Even with effective cleanliness programs, there may be some resident debris such as dust and dirt. The potential for plugging the recirculation screens is a current PWR licensing issue. The AP1000 design provides inherent advantages with respect to the potential plugging of containment recirculation screens. These characteristics include prevention of fibrous debris generation, improved debris settling and improved recirculation screen design. Debris settling analysis demonstrates that failure of coatings does not result in debris being transported to the screens before it settles to the floor. Additional analysis also shows that the plant can tolerate conservative amounts of resident debris being transported to the screens. The AP1000 significantly reduces the probability of plugging the containment recirculation screens and significantly reduces inspection and maintenance of coatings used inside containment. (authors)

  17. AP Theory IV: Intrinsic Topological Quantum Langlands Theory

    E-print Network

    H. E. Winkelnkemper

    2010-10-25

    Without using any moduli, sheaves, stacks, nor any analytic, nor category-type arguments, we exhibit an analogue to Geometric Langlands Theory in an entirely model-independent, non-perturbative,purely smooth topological context in Artin Presentation Theory. A basic initial feature is that AP Theory, as a whole, is already, ab initio, a universal canonical 2D sigma-model, targeting smooth, compact, simply-connected 4-manifolds with a connected boundary, and its topological Planckian quantum starting point, as well as its cone-like, infinitely-generated at each stage, graded group of homology-preserving, but topology-changing transitions/interactions, exhibit the most general qualitative S-duality. We first point out the numerous mathematically rigorous, model-free, (i.e., intrinsic), topological AP analogues with the heuristic Kapustin-Witten version of Geometric Langlands theory, as well as the crucial differences between the two theories. The latter have to exist since AP Theory deals, a priori, essentially only with discrete group-theoretic presentation theory, not Lie group representation theory, not with category nor moduli theory, does not need classical SUSY, nor Feynman integrals, lattice models, etc., and furthermore is model-independent and characteristic of real dimension four. It will become clear that AP Langlands theory is a model-independent, cone-like, graded, compact completion and topological 'envelope' of 4D N=4 SUSY YM theory, their starting point, anchored, kept in place, so to speak, by a purely discrete group-theoretic analogue of Donaldson/Seiberg-Witten theory. Due to its discrete group-theoretic conceptual simplicity and universality, the AP Langlands program should also be considered to be a new type of intrinsic model-free symmetry, a universal Erlanger Program for Modern Physics.

  18. Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, VCP.

    PubMed

    Druck, T; Gu, Y; Prabhala, G; Cannizzaro, L A; Park, S H; Huebner, K; Keen, J H

    1995-11-01

    Clathrin-coated vesicles, involved in endocytosis and Golgi processing, have a surface lattice containing clathrin triskelia and stoichiometric amounts of additional components termed "assembly proteins," or APs. The AP form at the plasma membrane, AP2, is composed of two large subunits of 100-115 kDa, denoted AP2 alpha and AP2 beta, a medium chain of 50 kDa, designated AP50, and a small chain. We have determined human chromosomal locations of genes for a large AP2 beta (CLAPB1) and a medium (CLAPM1) AP subunit and of a novel clathrin-binding protein, VCP, that binds clathrin simultaneously with APs. Chromosomal in situ hybridization of a human genomic clone demonstrated that the CLAPM1 gene mapped to chromosome region 3q28. The gene for the CLAPB1 large subunit was mapped to 17q11.2-q12 by PCR amplification of an AP2 beta fragment from a panel of rodent-human hybrid DNAs. To map the human VCP sequence, a human-specific probe was made by RT-PCR of human mRNA using oligonucleotide primers from conserved regions of the porcine sequence. The amplified human fragment served as probe on Southern blots of hybrid DNAs to determine that the human VCP locus maps to chromosome region 9pter-q34. PMID:8595912

  19. Hot isostatic pressing of ceramics

    NASA Technical Reports Server (NTRS)

    Honma, K.

    1985-01-01

    A mixture containing glass 70 to 95 and BN or B4C powder (0.1-10 microns) 5 to 30 vol. % is used as a secondary pressure medium in hot isostatic pressing of ceramics. Thus, Pyrex beads were mixed with 15% vol. BN powder (average diameter 2 microns), fused at 1400 deg for 2 h, cooled, crushed, and put into a graphite crucible. A Si3N4 sintered body was embedded in the powder, heated in vacuum at 1200 deg for 2 h, treated in a hot isostatic press furnace at 1700 deg and 1000 atm. for 1 h, and cooled to give a Si3N4 ceramic. It was easily separated from the crucible.

  20. Synaptic and genomic responses to JNK and AP-1 signaling in Drosophilaneurons

    E-print Network

    Narayanan, Radhakrishnan

    Background: The transcription factor AP-1 positively controls synaptic plasticity at the Drosophila neuromuscular junction. Although in motor neurons, JNK has been shown to activate AP-1, a positive regulator of growth and ...

  1. Aviation Safety Program: Weather Accident Prevention (WxAP) Development of WxAP System Architecture And Concepts of Operation

    NASA Technical Reports Server (NTRS)

    Grantier, David

    2003-01-01

    This paper presents viewgraphs on the development of the Weather Accident Prevention (WxAP) System architecture and Concept of Operation (CONOPS) activities. The topics include: 1) Background Information on System Architecture/CONOPS Activity; 2) Activity Work in Progress; and 3) Anticipated By-Products.

  2. Slurry-pressing consolidation of silicon nitride

    NASA Technical Reports Server (NTRS)

    Sanders, William A.; Kiser, James D.; Freedman, Marc R.

    1988-01-01

    A baseline slurry-pressing method for a silicon nitride material is developed. The Si3N4 composition contained 5.8 wt percent SiO2 and 6.4 wt percent Y2O3. Slurry-pressing variables included volume percent solids, application of ultrasonic energy, and pH. Twenty vol percent slurry-pressed material was approximately 11 percent stronger than both 30 vol percent slurry-pressed and dry-pressed materials. The Student's t-test showed the difference to be significant at the 99 percent confidence level. Twenty volume percent (300 h) slurry-pressed test bars exhibited strengths as high as 980 MPa. Large, columnar beta-Si3N4 grains caused failure in the highest strength specimens. The improved strength correlated with better structural uniformity as determined by radiography, optical microscopy, and image analysis.

  3. Effect of enzyme-aided cell wall disintegration on protein extractability from intact and dehulled rapeseed (Brassica rapa L. and Brassica napus L.) press cakes.

    PubMed

    Rommi, Katariina; Hakala, Terhi K; Holopainen, Ulla; Nordlund, Emilia; Poutanen, Kaisa; Lantto, Raija

    2014-08-13

    Cell-wall- and pectin-degrading enzyme preparations were used to enhance extractability of proteins from rapeseed press cake. Rapeseed press cakes from cold pressing of intact Brassica rapa and partially dehulled Brassica napus seeds, containing 36-40% protein and 35% carbohydrates, were treated with pectinolytic (Pectinex Ultra SP-L), xylanolytic (Depol 740L), and cellulolytic (Celluclast 1.5L) enzyme preparations. Pectinex caused effective disintegration of embryonic cell walls through hydrolysis of pectic polysaccharides and glucans and increased protein extraction by up to 1.7-fold in comparison to treatment without enzyme addition. Accordingly, 56% and 74% of the total protein in the intact and dehulled press cakes was extracted. Light microscopy of the press cakes suggested the presence of pectins colocalized with proteins inside the embryo cells. Hydrolysis of these intracellular pectins and deconstruction of embryonic cell walls during Pectinex treatment were concluded to relate with enhanced protein release. PMID:25039585

  4. Expanded Analysis of Hot Isostatic Pressed Iodine-Loaded Silver-Exchanged Mordenite

    SciTech Connect

    Jubin, R. T.; Bruffey, S. H.; Patton, K. K.

    2014-09-30

    Reduced silver-exchanged mordenite (Ag0Z) is being evaluated as a potential material to control the release of radioactive iodine that is released during the reprocessing of used nuclear fuel into the plant off-gas streams. The purpose of this study was to determine if hot pressing could directly convert this iodine loaded sorbent into a waste form suitable for long-term disposition. The minimal pretreatment required for production of pressed pellets makes hot pressing a technically and economically desirable process. Initial scoping studies utilized hot uniaxial pressing (HUPing) to prepare samples of non-iodine-loaded reduced silver exchanged mordenite (Ag0Z). The resulting samples were very fragile due to the low pressure (~ 28 MPa) used. It was recommended that hot isostatic pressing (HIPing), performed at higher temperatures and pressures, be investigated. HIPing was carried out in two phases, with a third and final phase currently underway. Phase I evaluated the effects of pressure and temperature conditions on the manufacture of a pressed sample. The base material was an engineered form of silver zeolite. Six samples of Ag0Z and two samples of I-Ag0Z were pressed. It was found that HIPing produced a pressed pellet of high density. Analysis of each pressed pellet by scanning electron microscopy-energy dispersive spectrophotometry (SEM-EDS) and X-ray diffraction (XRD) demonstrated that under the conditions used for pressing, the majority of the material transforms into an amorphous structure. The only crystalline phase observed in the pressed Ag0Z material was SiO2. For the samples loaded with iodine (I-Ag0Z) iodine was present as AgI clusters at low temperatures, and transformed into AgIO4 at high temperatures. Surface mapping and EDS demonstrate segregation between silver iodide phases and silicon dioxide phases. Based on the results of the Phase I study, an expanded test matrix was developed to examine the effects of multiple source materials, compositional variations, and an expanded temperature range. Each sample was analyzed with the approach used in Phase I. In all cases, there is nothing in the SEM or XRD analyses that indicates creation of any AgI-containing silicon phase, with the samples being found to be largely amorphous. Phase III of this study has been initiated and is the final phase of scoping tests. It will expand upon the test matrix completed in Phase II and will examine the durability of the pressed pellets through product consistency testing (PCT) studies. Transformation of the component material into a well-characterized iodine-containing mineral phase would be desirable. This would limit the additional experimental testing and modeling required to determine the long-term stability of the pressed pellet, as much of that information has already been learned for several common iodine-containing minerals. However, this is not an absolute requirement, especially if pellets produced by hot isostatic pressing can be demonstrated through initial PCT studies to retain iodine well despite their amorphous composition.

  5. NASA/MSFC Large Stretch Press Study

    NASA Technical Reports Server (NTRS)

    Choate, M. W.; Nealson, W. P.; Jay, G. C.; Buss, W. D.

    1985-01-01

    The purpose of this study was to: A. assess and document the advantages/disadvantages of a government agency investment in a large stretch form press on the order of 5000 tons capacity (per jaw); B. develop a procurement specification for the press; and C. provide trade study data that will permit an optimum site location. Tasks were separated into four major elements: cost study, user survey, site selection, and press design/procurement specification.

  6. AP Studio Art as an Enabling Constraint for Secondary Art Education

    ERIC Educational Resources Information Center

    Graham, Mark A.

    2009-01-01

    Advanced Placement (AP) Studio Art is an influential force in secondary art education as is evident in the 31,800 portfolios submitted for review in 2008. From the perspectives of a high school educator and AP Reader, this author has observed how the constraints of the AP program can be used to generate support for high school art programs and…

  7. APS: 125 Years of Progress of Physiology as a Scientific Discipline and a Profession

    ERIC Educational Resources Information Center

    Carroll, Robert G.; Frank, Martin; Ra'anan, Alice; Matyas, Marsha L.

    2013-01-01

    The Experimental Biology 2012 meeting in San Diego, CA, included events to celebrate the 125th anniversary of the founding of the American Physiological Society (APS) and reflect on the recent accomplishments of the society. Most of the APS activities in the past quarter century were guided by a series of strategic plans. Membership in the APS

  8. IEEE/ACM TRANSACTIONS ON NETWORKING, VOL. , NO. , 2013 1 AP Association for Proportional Fairness in

    E-print Network

    Cheng, Xiuzhen "Susan"

    - tributed among all APs, RSSI based approach may overload some APs while leave others to carry very light, we propose a distributed heuristic BPF based on a novel performance revenue function, which provides times of other users associated with the same AP can be redistributed easily based on NLAO-PF. Extensive

  9. Circadian regulation of a transcription factor, ApC/EBP, in the eye of Aplysia californica

    E-print Network

    Circadian regulation of a transcription factor, ApC/EBP, in the eye of Aplysia californica Samer of the circadian oscillator with circadian rhythms of ApC/EBP mRNA present under constant dark conditions. Therefore, ApC/EBP is a candidate gene for a circadian transcription factor to mediate circadian responses

  10. Masters Engineering ELITE Programme Applying Innovation in Engineering University of Toronto APS1013

    E-print Network

    Toronto, University of

    Masters Engineering ELITE Programme Applying Innovation in Engineering University of Toronto APS Engineering ELITE Programme Applying Innovation in Engineering University of Toronto APS1013 Copyright © AMGI1013 Copyright © AMGI Inc 2012-2015 Generic Syllabus 5th Sept 2014 1 Applying Innovation - APS1013

  11. Using a Classroom Response System to Improve Multiple-Choice Performance in AP[R] Physics

    ERIC Educational Resources Information Center

    Bertrand, Peggy

    2009-01-01

    Participation in rigorous high school courses such as Advanced Placement (AP[R]) Physics increases the likelihood of college success, especially for students who are traditionally underserved. Tackling difficult multiple-choice exams should be part of any AP program because well-constructed multiple-choice questions, such as those on AP exams and…

  12. College Completion: Comparing AP®, Dual-Enrolled, and Nonadvanced Students. Research Report 2014-3

    ERIC Educational Resources Information Center

    Godfrey, Kelly; Matos-Elefonte, Haifa; Ewing, Maureen; Patel, Priyank

    2014-01-01

    The study presented here is an investigation and comparison of the relationships between the Advanced Placement Program® (AP®) and dual-enrolled high school courses and college outcomes. Previous research provides evidence that participation in AP, and subsequent success on AP Exams, is positively related to various college outcomes including an…

  13. 29 CFR 1910.217 - Mechanical power presses.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (4) Flywheels and bearings. Presses whose...press strokes caused by bearing seizure. (5) Brake...brake wear or other factors extend press stopping...Bearings Lubrication of bearings is considered the single...stresses and environmental factors affecting safety...

  14. Relationship between major geophysical events and the planetary magnetic Ap index, from 1844 to the present

    NASA Astrophysics Data System (ADS)

    Casati, Michele; Straser, Valentino

    2015-04-01

    In this study, for the first time, we compared the annual magnetic Ap index, taken from original sources, from 1844 to the present day [Svalgaard,2014], with: i) sixteen large volcanic eruptions of index VEI5 + recorded by, Smithsonian Institute (Global Volcanism Program), ii) three sets of the volcanic aerosols data [Ammann et.al, 2003][Gao;Chaochao;Alan Robock;Caspar Ammann,2008][Traufetter et.al,2004] and iii) eight major earthquakes of a magnitude between 8.7Ap index. Specifically, in the downward phase of the planetary Ap index, under the annual value of 7 or, in the phase when the annual value exceeded 22. We identified a total of 14 transitions (eight in the solar minimum and six in the solar maxima) each with a period of about two and a half years making a total of almost 35 years of activity during the 169 years under review. During the 14 transitions 18 of the 24 major historical geophysical events occurred from 1844 to the present. Analysis of data shows a clear link between the electromagnetic (EM) dynamics recorded in large historical solar minima (Maunder, Dalton or solar minimum 1880-1920), the large solar maxima (solar cycles 19, 21 & 22) and the energy released during large geophysical events [Casati,2014]. The physical process of solar-terrestrial interaction, also reveal a deep and intrinsic relationship between the EM dynamics of the inner solar system and the temporal occurrence of major geophysical events. The references in scientific literature, in support of this work, are numerous: from empirical evidence, that we find in the late nineteenth century - early twentieth century, to more recent references. Some of which are: [Casey,2010][Charvátová, 2010][Choi, 2010][Duma; Vilardo, 1998][Khachikyan et al,2014][Kolvankar,2008][Kovalyov,2014][Mazzarella;Palumbo,1989][Stothers,1989][St?eštik,2003][Sytinsky,1987 ,1989, 1998].

  15. arXiv:0904.1879v1[astro-ph.CO]12Apr2009 ApJ, in press

    E-print Network

    Taylor, Greg

    Jets of the Radio Galaxy 1946+708 G. B. Taylor1, P. Charlot2,3, R. C. Vermeulen4, and N. Pradel4 0.6 and 0.9 c. From the constraint that jet components cannot have intrinsic velocities faster than selected at high frequencies (Taylor, Readhead, & Pearson 1 Department of Physics and Astronomy, University

  16. arXiv:astro-ph/0409624v127Sep2004 ApJ in press -10 Jan 2005 issue

    E-print Network

    Taylor, Greg

    with a relatively high core flux density (> 100 mJy at 6 cm). This clearly favors objects with a beamed core, i.e., oriented at a small angle with respect to the line of sight. We will refer to this sample as the Bologna

  17. Crystal structures of Salmonella typhimurium propionate kinase and its complex with Ap4A: evidence for a novel Ap4A synthetic activity.

    PubMed

    Simanshu, Dhirendra K; Savithri, H S; Murthy, M R N

    2008-03-01

    Propionate kinase catalyses the last step in the anaerobic breakdown of L-threonine to propionate in which propionyl phosphate and ADP are converted to propionate and ATP. Here we report the structures of propionate kinase (TdcD) in the native form as well as in complex with diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) by X-ray crystallography. Structure of TdcD obtained after cocrystallization with ATP showed Ap4A bound to the active site pocket suggesting the presence of Ap4A synthetic activity in TdcD. Binding of Ap4A to the enzyme was confirmed by the structure determination of a TdcD-Ap4A complex obtained after cocrystallization of TdcD with commercially available Ap4A. Mass spectroscopic studies provided further evidence for the formation of Ap4A by propionate kinase in the presence of ATP. In the TdcD-Ap4A complex structure, Ap4A is present in an extended conformation with one adenosine moiety present in the nucleotide binding site and other in the proposed propionate binding site. These observations tend to support direct in-line transfer of phosphoryl group during the kinase reaction. PMID:17894350

  18. PsAP2 an AP2/ERF family transcription factor from Papaver somniferum enhances abiotic and biotic stress tolerance in transgenic tobacco.

    PubMed

    Mishra, Sonal; Phukan, Ujjal J; Tripathi, Vineeta; Singh, Dhananjay K; Luqman, Suaib; Shukla, Rakesh Kumar

    2015-09-01

    The AP2/ERFs are one of the most important family of transcription factors which regulate multiple responses like stress, metabolism and development in plants. We isolated PsAP2 a novel AP2/ERF from Papaver somniferum which was highly upregulated in response to wounding followed by ethylene, methyl jasmonate and ABA treatment. PsAP2 showed specific binding with both DRE and GCC box elements and it was able to transactivate the reporter genes in yeast. PsAP2 overexpressing transgenic tobacco plants exhibited enhanced tolerance towards both abiotic and biotic stresses . Real time transcript expression analysis showed constitutive upregulation of tobacco Alternative oxidase1a and Myo-inositol-1-phosphate synthase in PsAP2 overexpressing tobacco plants. Further, PsAP2 showed interaction with NtAOX1a promoter in vitro, it also specifically activated the NtAOX1a promoter in yeast and tobacco BY2 cells. The silencing of PsAP2 using VIGS lead to significant reduction in the AOX1 level in P. somniferum. Taken together PsAP2 can directly bind and transcriptionally activate NtAOX1a and its overexpression in tobacco imparted increased tolerance towards both abiotic and biotic stress. PMID:26319514

  19. Airborne Precision Spacing (APS) Dependent Parallel Arrivals (DPA)

    NASA Technical Reports Server (NTRS)

    Smith, Colin L.

    2012-01-01

    The Airborne Precision Spacing (APS) team at the NASA Langley Research Center (LaRC) has been developing a concept of operations to extend the current APS concept to support dependent approaches to parallel or converging runways along with the required pilot and controller procedures and pilot interfaces. A staggered operations capability for the Airborne Spacing for Terminal Arrival Routes (ASTAR) tool was developed and designated as ASTAR10. ASTAR10 has reached a sufficient level of maturity to be validated and tested through a fast-time simulation. The purpose of the experiment was to identify and resolve any remaining issues in the ASTAR10 algorithm, as well as put the concept of operations through a practical test.

  20. Variability of Balmer Profiles in Magnetic Ap/Bp Stars

    NASA Astrophysics Data System (ADS)

    Valyavin, G.; Lee, B.-C.; Shulyak, D.; Han, I.; Kochukhov, O.; Khang, D.-I.; Kim, K.-M.

    2007-06-01

    A set of high precision measurements of weak variations of hydrogen lines in spectra of seven magnetic Ap/Bp stars was carried out using the BOES echelle spectrograph of the Bohuynsan Optical Astronomy Observatory (South Korea). A weak (1-2 %) periodic variability of the Balmer line wings has been detected in the spectra of 2 program stars. Upper limits of possible variations are presented for the remaining 5 objects. We discuss the discovered variability in the framework of model atmospheres with magnetic force terms included. The periodic changes in the Balmer profiles are caused by perturbations in atmospheres of Ap/Bp stars due to their rotationally modulated non-force-free magnetic fields.

  1. Time resolved spectroscopy of the cool Ap star HD 213637*

    NASA Astrophysics Data System (ADS)

    Elkin, V. G.; Kurtz, D. W.; Mathys, G.

    2015-02-01

    We present an analysis of high time resolution spectra of the chemically peculiar Ap star HD 213637. The star shows rapid radial velocity variations with a period close to the photometric pulsation period. Radial velocity pulsation amplitudes vary significantly for different rare earth elements. The highest pulsation amplitudes belong to lines of Tb III (˜360 m s-1), Pr II (˜250 m s-1) and Pr III (˜230 m s-1). We did not detect any pulsations from spectral lines of Eu II and in H?, in contrast to many other roAp stars. We also did not find radial velocity pulsations using spectral lines of other chemical elements, including Mg, Si, Ca, Sc, Cr, Fe, Ni, Y and Ba. There are phase shifts between the maxima of pulsation amplitudes of different rare earth elements and ions, which is evidence of an outwardly running magneto-acoustic wave propagating through the upper stellar atmosphere.

  2. Tank 241-AP-107 tank characterization plan. Revision 1

    SciTech Connect

    Schreiber, R.D.

    1995-01-20

    Defense Nuclear Facilities Safety Board has directed the DOE to concentrate ear-term sampling and analysis activities on identification and resolution of issues (Conway 1993). The Data Quality Objective (DQO) process was chosen as a tool to be used in the resolution of safety issues. As a result, a revision in the Federal Facilities Agreement and Consent Order (Tri-Party Agreement) milestone M-44-00 has been made, which states that ``A Tank Characterization Plan (TCP) will be developed for each double-shell tank (DST) and single-shell tank (SST) using the DQO process; Development of TCPs by the DQO process is intended to allow users (e.g., Hanford Facility user groups, regulators) to ensure their needs will be met and that resources are devoted to gaining only necessary information.`` This document satisfies that requirement for the tank 241-AP-107 (AP-107).

  3. Endothelin receptor B-mediated induction of c-jun and AP-1 in response to shear stress in human endothelial cells.

    PubMed

    Morawietz, H; Wagner, A H; Hecker, M; Goettsch, W

    2008-08-01

    In vivo, endothelial cells are constantly exposed to shear stress by flowing blood. Short-term exposure of endothelial cells to shear stress has been shown to induce endothelin-1 release. It is currently unknown, however, whether this shear stress-dependent endothelin-1 release affects the expression and activity of transcription factors. In this study, primary cultures of human endothelial cells from the umbilical vein were exposed to laminar shear stress in a cone-and-plate viscometer. Laminar shear stress for 30 min induced a 2-fold increase in mRNA expression of c-jun , but not c-fos, in human endothelial cells. Blockade of endothelin receptor subtype B (ET B) with BQ788 prevented this shear stress-dependent induction of c-jun expression. The induction of c-jun by shear stress involved protein kinase C and endothelial NO synthase. In addition, exposure of endothelial cells to arterial laminar shear stress for 1 h increased the binding of transcription factor AP-1 to its consensus sequence by 1.7-fold in electrophoretic mobility shift assays. This induction was also mediated by an ET B-dependent pathway. Supershift analysis supports an AP-1 complex containing c-jun, but not c-fos, in human endothelial cells. In conclusion, our data suggest endothelin-1-mediated induction of c-jun expression and activation of AP-1 (possibly as a c-jun homodimer) by laminar shear stress in human endothelial cells. PMID:18758496

  4. Linking radio and gamma-ray emission in Ap Librae

    NASA Astrophysics Data System (ADS)

    Hervet, O.; Boisson, C.; Sol, H.

    2015-06-01

    Ap Lib is one of the rare low-synchrotron-peaked blazars detected so far at TeV energies. This type of source is not properly modelled by standard one-zone leptonic synchrotron self-Compton (SSC) emission scenarios. The aim of this paper is to study the relevance of additional components that should naturally occur in an SSC scenario for a better understanding of the emission mechanisms, especially at very high energies (VHE). We use simultaneous data from a multi-wavelength campaign of the Planck, Swift-UVOT, and Swift-XRT telescopes carried out in February 2010, as well as quasi-simultaneous data of WISE, Fermi, and HESS taken in 2010. The multi-lambda emission of Ap Lib is modelled by a blob-in-jet SSC scenario including the contribution of the base of the VLBI-extended jet, the radiative blob-jet interaction, the accretion disk, and its associated external photon field. We show that signatures of a strong parsec-scale jet and of an accretion disk emission are present in the spectral energy distribution. We can link the observational VLBI jet features from MOJAVE to parameters expected for a VHE-emitting blob accelerated near the jet base. The VHE emission appears to be dominated by the inverse-Compton effect of the blob relativistic electrons interacting with the jet synchrotron radiation. In this scenario, Ap Lib appears as an intermediate source between BL Lac objects and flat-spectrum radio quasars. Ap Lib could be a bright representative of a specific class of blazars, in which the parsec-scale jet luminosity is no more negligible compared to the blob and contributes to the high-energy emission through inverse-Compton processes.

  5. ALLUVIAL CHANNEL GEOMETRY: THEORY AND ApPLICATIONS

    E-print Network

    Julien, Pierre Y.

    ALLUVIAL CHANNEL GEOMETRY: THEORY AND ApPLICATIONS 8 TABLE 2. Variation of q with hid. according to (32) and (36) hId. q (1) (2) Discussion by Willi H. Hager,3 Fellow, ASCE 10° 1.23 x J(i 10' 6.5 x 10 this function and one may note that q increases very rapidly with hid" The function under consideration may

  6. Diffusion and Settling in Ap/Bp Stars

    SciTech Connect

    Turcotte, S

    2003-04-09

    Ap/Bp stars are magnetic chemically peculiar early A and late B type stars of the main sequence. They exhibit peculiar surface abundance anomalies that are thought to be the result of gravitational settling and radiative levitation. The physics of diffusion in these stars are reviewed briefly and some model predictions are discussed. While models reproduce some observations reasonably well, more work is needed before the behavior of diffusing elements in a complex magnetic field is fully understood.

  7. The roAp Star with the Strongest Magnetic Field: Characterizing HD 154708

    NASA Astrophysics Data System (ADS)

    Hubrig, S.; Kurtz, D. W.; Schöller, M.; Wolff, B.; Elkin, V. G.; Mathys, G.

    2012-09-01

    The rapidly oscillating Ap (roAp) stars with very strong magnetic fields are of special interest because the effect of the magnetic field on the structure of their atmospheres can be studied with the greatest detail and accuracy. The cool roAp star HD 154708 possesses the strongest magnetic field among the roAp stars, with a mean magnetic field modulus = 24.5 ± 1.0 kG, which is about a factor of three greater than that of HD 166473, Ap star with the second-strongest magnetic field.

  8. A Semi-automated Abundance Survey of Ap Stars

    NASA Astrophysics Data System (ADS)

    Hall, Martin P.; Kurtz, Don; Elkin, Vladimir; Bruntt, Hans

    2015-08-01

    We have carried out an abundance analysis on the high-resolution spectra of approximately 350 Ap stars collected between 2007 and 2010 on the FEROS Echelle (Fibre-led, Extended Range, Echelle ) spectrograph housed at the 2.2-m telescope at European Southern Observatory at La Silla, Chile. We employed the VWA package (vsin I, wavelength shift, abundance analysis) for preliminary selection of spectral lines, and a semi-automated set of routines which we developed in the programming language IDL, to calculate the equivalent widths and abundances of ions of Iron and the rare earth elements Neodymium and Praseodymium using the WIDTH program and NEMO model atmospheres. Initial results are presented, which reinforce the correlation between iron abundance and effective temperature, from an over-abundance in the late Bp stars, to under-abundant in the early F stars. Results also suggest that the disequilibrium in abundances of the first and second ionisation stages of these ions in the rapidly oscillating Ap (roAp) stars may a consequence of the relatively cool temperatures of those stars, rather than a signature of pulsation.

  9. Long-term stability of the APS storage ring

    SciTech Connect

    Friedsam, H.; Penicka, M.; Error, J.

    1999-10-26

    The Advanced Photon Source (APS), a third-generation synchrotrons light source, was commissioned in 1995 at Argonne ''National Laboratory and has been fully-operational for beamline users since 1997. The APS storage ring can accommodate up to 68 user beamlines; about 70% of the available beamlines are currently in use by various collaborative access teams (CATS). The 7-GeV synchrotrons light source produces light in the soft to hard x-ray range that is used for research in such areas as x-ray instrumentation; material, chemical and atomic sciences; biology; and geo/soil/ environmental sciences. For the successful operation of an x-ray light source such as the Advanced Photon Source, the long-term stability of the concrete floor supporting the beam components and user beamlines is crucial. Settlements impact the orbit and location of the x-ray source points as well as the position of the x-ray beamlines. This paper compares the results of two successive resurveys of the APS accelerator components performed in 1995 and 1998.

  10. Long-term stability of the APS storage ring

    SciTech Connect

    Friedsam, H.; Penicka, M.; Error, J.

    2000-03-16

    The Advanced Photon Source (APS), a third-generation synchrotron light source, was commissioned in 1995 at Argonne National Laboratory and has been fully operational for beamline users since 1997. The APS storage ring can accommodate up to 68 user beamlines; about 70% of the available beamlines are currently in use by various collaborative access teams (CATs). The 7-GeV synchrotron light source produces light in the soft to hard x-ray range that is used for research in such areas as x-ray instrumentation; material, chemical and atomic sciences; biology; and geo/soil/environmental sciences. For the successful operation of an x-ray light source such as the Advanced Photon Source, the long-term stability of the concrete floor supporting the beam components and user beamlines is crucial. Settlements impact the orbit and location of the x-ray source points as well as the position of the x-ray beamlines. This paper compares the results of two successive resurveys of the APS accelerator components performed in 1995 and 1998.

  11. Transcription factor AP-2gamma regulates murine adenosine deaminase gene expression during placental development.

    PubMed

    Shi, D; Kellems, R E

    1998-10-16

    Trophoblast cells are specialized extra-embryonic cells present only in eutherian mammals. They play a major role in the implantation and placentation processes. To understand better the molecular mechanisms that control the development and function of trophoblast cells, we sought to identify the transcription factors that regulate murine adenosine deaminase (ADA) gene expression in the placenta. Here we report a detailed characterization of a placenta-specific footprinting region (FP1) in the Ada placental regulatory element. The sequence of FP1 was mapped by DNase I footprinting and was found to match a consensus AP-2 transcription factor-binding site. Electrophoretic mobility shift assays demonstrated that FP1 interacted with AP-2-like proteins. Further analysis using AP-2 antibody confirmed that AP-2 protein was indeed present in the placenta and bound to FP1. Mutation at the AP-2 site in FP1 abolished the ability of the Ada placental regulatory element to bind AP-2 proteins and failed to target chloramphenicol acetyltransferase reporter gene expression to placentas in transgenic mice, indicating that AP-2 is required for Ada expression in the placenta. In addition, RNase protection assays demonstrated that AP-2gamma was the predominant AP-2 family member expressed in the placenta. In situ hybridization analysis revealed that AP-2gamma expression was enriched in the trophoblast lineage throughout development, suggesting that AP-2gamma may be critical for trophoblast development and differentiation. PMID:9765260

  12. Molecular Basis for Enhancement of the Meiotic DMCI Recombinase by RAD51AP1

    SciTech Connect

    Dray, Eloise; Dunlop, Myun Hwa; Kauppi, Liisa; San Filippo, Joseph San; Wiese, Claudia; Tsai, Miaw-Sheue; Begovic, Sead; Schild, David; Jasin, Maria; Keeney, Scott; Sung, Patrick

    2010-11-05

    Homologous recombination is needed for meiotic chromosome segregation, genome maintenance, and tumor suppression. RAD51AP1 (RAD51 Associated Protein 1) has been shown to interact with and enhance the recombinase activity of RAD51. Accordingly, genetic ablation of RAD51AP1 leads to enhanced sensitivity to and also chromosome aberrations upon DNA damage, demonstrating a role for RAD51AP1 in mitotic homologous recombination. Here we show physical association of RAD51AP1 with the meiosis-specific recombinase DMC1 and a stimulatory effect of RAD51AP1 on the DMC1-mediated D-loop reaction. Mechanistic studies have revealed that RAD51AP1 enhances the ability of the DMC1 presynaptic filament to capture the duplex DNA partner and to assemble the synaptic complex, in which the recombining DNA strands are homologously aligned. We also provide evidence that functional co-operation is dependent on complex formation between DMC1 and RAD51AP1, and that distinct epitopes in RAD51AP1 mediate interactions with RAD51 and DMC1. Finally, we show that RAD51AP1 is expressed in mouse testes, and that RAD51AP1 foci co-localize with a subset of DMC1 foci in spermatocytes. These results suggest that RAD51AP1 also serves an important role in meiotic homologous recombination.

  13. Adaptor Protein2 (AP2) orchestrates CXCR2-mediated cell migration

    PubMed Central

    Raman, Dayanidhi; Sai, Jiqing; Hawkins, Oriana; Richmond, Ann

    2014-01-01

    The chemokine receptor CXCR2 is vital for inflammation, wound healing, angiogenesis, cancer progression, and metastasis. Adaptor protein 2 (AP2), a clathrin binding heterotetrameric protein comprised of ?, ?2, ?2, and ?2 subunits, facilitates clathrin-mediated endocytosis. Mutation of the LLKIL motif in the CXCR2 carboxyl-terminal domain (CTD) results in loss of AP2 binding to the receptor and loss of ligand mediated receptor internalization and chemotaxis. AP2 knockdown also results in diminished ligand-mediated CXCR2 internalization, polarization and chemotaxis. Using knockdown/rescue approaches with AP2-?2 mutants, the binding domains were characterized in reference to CXCR2 internalization and chemotaxis. When in an open conformation, ?2 Patch 1 and Patch 2 domains bind tightly to membrane PIP2 phospholipids. When AP2-?2 is replaced with ?2 mutated in Patch 1 and/or Patch 2 domains, ligand-mediated receptor binding and internalization are not lost. However chemotaxis requires AP2-?2 Patch 1, but not Patch 2. AP2-?2 has been demonstrated to bind dileucine motifs to facilitate internalization. Expression of AP2-?2 V88D and V98S dominant negative mutants resulted in loss of CXCR2 mediated chemotaxis. Thus, AP2 binding to both membrane phosphatidylinositol phospholipids and dileucine motifs is crucial for directional migration or chemotaxis. Moreover, AP2-mediated receptor internalization can be dissociated from AP2-mediated chemotaxis. PMID:24450359

  14. The Drosophila melanogaster Mutants apblot and apXasta Affect an Essential apterous Wing Enhancer

    PubMed Central

    Bieli, Dimitri; Kanca, Oguz; Gohl, Daryl; Denes, Alexandru; Schedl, Paul; Affolter, Markus; Müller, Martin

    2015-01-01

    The selector gene apterous (ap) plays a key role during the development of the Drosophila melanogaster wing because it governs the establishment of the dorsal-ventral (D-V) compartment boundary. The D-V compartment boundary is known to serve as an important signaling center that is essential for the growth of the wing. The role of Ap and its downstream effectors have been studied extensively. However, very little is known about the transcriptional regulation of ap during wing disc development. In this study, we present a first characterization of an essential wing-specific ap enhancer. First, we defined an 874-bp fragment about 10 kb upstream of the ap transcription start that faithfully recapitulates the expression pattern of ap in the wing imaginal disc. Analysis of deletions in the ap locus covering this element demonstrated that it is essential for proper regulation of ap and formation of the wing. Moreover, we showed that the mutations apblot and apXasta directly affect the integrity of this enhancer, leading to characteristic wing phenotypes. Furthermore, we engineered an in situ rescue system at the endogenous ap gene locus, allowing us to investigate the role of enhancer fragments in their native environment. Using this system, we were able to demonstrate that the essential wing enhancer alone is not sufficient for normal wing development. The in situ rescue system will allow us to characterize the ap regulatory sequences in great detail at the endogenous locus. PMID:25840432

  15. Freedom of the Press vs. Public Access.

    ERIC Educational Resources Information Center

    Schmidt, Benno C., Jr.

    This book surveys the implications of freedom of the press for a constitutionally rooted public right of access to electronic and print media. Part one provides general perspectives on access to the media, including discussions of access in relation to the Supreme Court, to First Amendment history and theory, to current perceptions of the press,…

  16. Teenagers as Victims in the Press

    ERIC Educational Resources Information Center

    Andersson, Gunvor; Lundstrom, Tommy

    2007-01-01

    Research into press reporting on young people has tended to concentrate on young people as offenders. In contrast, this article focuses on press coverage of teenagers as victims. Reports in two Swedish newspapers (a morning broadsheet and an evening tabloid) were studied over a period of four months and subjected to a qualitative analysis of…

  17. Columbia University Press: Trading on Tradition.

    ERIC Educational Resources Information Center

    Fialkoff, Francine

    1998-01-01

    Columbia University Press's current and future solvency rests on a complex balance of reference, scholarly, and trade titles as well as an innovative collaboration with the library to help guarantee the house's preeminence in the academic community. The Press's strategic approach is described. (Author)

  18. Fracture toughness of hot-pressed beryllium

    NASA Technical Reports Server (NTRS)

    Lemon, D. D.; Brown, W. F., Jr.

    1985-01-01

    This paper presents the results of an investigation into the fracture toughness, sustained-load flaw growth, and fatigue-crack propagation resistance of S200E hot-pressed beryllium at room temperature. It also reviews the literature pertaining to the influence of various factors on the fracture toughness of hot-pressed beryllium determined using fatigue-cracked specimens.

  19. The Heptameric SmAP1 and SmAP2 Proteins of the Crenarchaeon Sulfolobus Solfataricus Bind to Common and Distinct RNA Targets

    PubMed Central

    Märtens, Birgit; Bezerra, Gustavo Arruda; Kreuter, Mathias Josef; Grishkovskaya, Irina; Manica, Andrea; Arkhipova, Valentina; Djinovic-Carugo, Kristina; Bläsi, Udo

    2015-01-01

    Sm and Sm-like proteins represent an evolutionarily conserved family with key roles in RNA metabolism. Sm-based regulation is diverse and can range in scope from eukaryotic mRNA splicing to bacterial quorum sensing, with at least one step in these processes being mediated by an RNA-associated molecular assembly built on Sm proteins. Despite the availability of several 3D-structures of Sm-like archaeal proteins (SmAPs), their function has remained elusive. The aim of this study was to shed light on the function of SmAP1 and SmAP2 of the crenarchaeon Sulfolobus solfataricus (Sso). Using co-purification followed by RNASeq different classes of non-coding RNAs and mRNAs were identified that co-purified either with both paralogues or solely with Sso-SmAP1 or Sso-SmAP2. The large number of associated intron-containing tRNAs and tRNA/rRNA modifying RNAs may suggest a role of the two Sso-SmAPs in tRNA/rRNA processing. Moreover, the 3D structure of Sso-SmAP2 was elucidated. Like Sso-SmAP1, Sso-SmAP2 forms homoheptamers. The binding of both proteins to distinct RNA substrates is discussed in terms of surface conservation, structural differences in the RNA binding sites and differences in the electrostatic surface potential of the two Sso-SmAP proteins. Taken together, this study may hint to common and different functions of both Sso-SmAPs in Sso RNA metabolism. PMID:25905548

  20. Recovery from the lethal effects of saxitoxin: a therapeutic window for 4-aminopyridine (4-AP).

    PubMed

    Benton, B J; Keller, S A; Spriggs, D L; Capacio, B R; Chang, F C

    1998-04-01

    We have shown that saxitoxin (STX) induced lethality can be reversed by 4-AP when it is administered at the time of respiratory arrest [Benton, B. J., Spriggs, D. L., Capacio, B. R. and Chang, F.-C. T. (1995) 4-Aminopyridine antagonizes the lethal effects of saxitoxin (STX) and tetrodotoxin (TTX). International Society of Toxicology, 5th Pan American Symposium on Animal, Plant and Microbial Toxins, Frederick, MD. July/August 1995, p. 217]. The purpose of this study was to determine whether 4-AP's efficacy could be enhanced further when administered at different times relative to STX intoxication. The animals used in this study were chronically instrumented for concurrent recordings of diaphragm electromyogram (DEMG), neck skeletal muscle electromyogram, Lead II electrocardiogram, and electrocorticogram (ECoG). There were five groups of unanesthetized guinea pigs. The first group served as 4-AP controls and received a 2 mg/kg i.m. dose of 4-AP. The four remaining groups were given a lethal dose of STX (5 microg/kg i.m.); the second group, STX controls, received no 4-AP; the third group, the 4-AP treatment group, received 4-AP immediately following cardiorespiratory collapse; the fourth group was the 4-AP/STX co-administration group and 4-AP was given concurrently with STX; and the fifth group was the 4-AP pretreatment group in which 4-AP was given 10 min before STX. At the point of STX-induced cardiorespiratory collapse, the guinea pigs were ventilated and given an i.p. injection of sodium bicarbonate. Results showed that 4-AP prevented cardiorespiratory collapse in 3/7 animals in the 4-AP pretreatment group. Also, 4-AP in conjunction with artificial ventilation and sodium bicarbonate accelerated recovery from STX-induced cardiorespiratory collapse in all the treatment groups compared to the STX controls. PMID:9643470

  1. Discourse analysis of the written press reports regarding rheumatoid arthritis, psoriasis, and psoriatic arthritis.

    PubMed

    Gabriel, Sequeira; Pia, Drozdowski Marina; Mabel, Gimenez Rey Marcela; Adrian, Schejtman; Mariana, Nuñez

    2014-09-01

    The management of rheumatoid arthritis (RA) and psoriasis/psoriatic arthritis (PS/PsA) has radically changed during the last decade modifying physicians' perception about those diseases. However, if communication and transfer of information, from doctors to patients, is not efficient, patients' perception could be influenced by other sources of information. The aim of this study is to analyze newspaper articles about RA or Ps/PsA published in the Argentinean written press between 1995 and 2010. Quantitative and qualitative analyses of all press articles that mentioned RA or Ps/PsA either on the headlines or in the text of the digital versions of the three main Argentinean newspapers from 1995 to 2010 were analyzed. A total of 166 press articles were analyzed; of these, 65.7 % of the articles were informative and the remaining were testimonials. Ninety-five articles were considered positives (57.2 %). Informative articles were positive with more frequency than the testimonials (64.2 vs. 43.9 %, p 0.02). Press articles that mentioned a new treatment were positive more frequently than those that did not mention it (78.3 vs. 49.2 %, p 0.001). Balanced articles included the opinion of, at least, one specialist in 84.2 versus the 48.1 % of the not balanced (p 0.02). Articles about RA and Ps/APs in Argentina tended to be positive all along the study period. A positive result was more frequent in those articles, which informed about a new treatment. The inclusion of the opinion of a professional is not associated with a positive result, although it is to a balanced article. PMID:24556936

  2. Implementing Strategies for Drying and Pressing Wood Without Emissions Controls

    SciTech Connect

    Sujit Banerjee; Terrance Conners

    2007-09-07

    Drying and pressing wood for the manufacture of lumber, particleboard, oriented strand board (OSB), veneer and medium density fiberboard (MDF) release volatile organic compounds (VOCs) into the atmosphere. These emissions require control equipment that are capital-intensive and consume significant quantities of natural gas and electricity. The objective of our work was to understand the mechanisms through which volatile organic compounds are generated and released and to develop simple control strategies. Of the several strategies developed, two have been implemented for OSB manufacture over the course of this study. First, it was found that increasing final wood moisture by about 2-4 percentage points reduced the dryer emissions of hazardous air pollutants by over 70%. As wood dries, the escaping water evaporatively cools the wood. This cooling tapers off wood when the wood is nearly dry and the wood temperature rises. Thermal breakdown of the wood tissue occurs and VOCs are released. Raising the final wood moisture by only a few percentage points minimizes the temperature rise and reduces emissions. Evaporative cooling also impacts has implications for VOC release from wood fines. Flaking wood for OSB manufacture inevitable generates fines. Fines dry out rapidly because of their high surface area and evaporative cooling is lost more rapidly than for flakes. As a result, fines emit a disproportionate quantity of VOCs. Fines can be reduced in two ways: through screening of the green furnish and through reducing their generation during flaking. The second approach is preferable because it also increased wood yield. A procedure to do this by matching the sharpness angle of the flaker knife to the ambient temperature was also developed. Other findings of practical interests are as follows: Dielectric heating of wood under low-headspace conditions removes terpenes and other extractives from softwood; The monoterpene content in trees depend upon temperature and seasonal effects; Method 25A emissions from lumber drying can be modeled from a knowledge of the airflow through the kiln; A heat transfer model shows that VOCs released during hot-pressing mainly originate from the surface of the board; and Boiler ash can be used to adsorb formaldehyde from air streams.

  3. Identification and Molecular Characterization of the Switchgrass AP2/ERF Transcription Factor Superfamily, and Overexpression of PvERF001 for Improvement of Biomass Characteristics for Biofuel

    PubMed Central

    Wuddineh, Wegi A.; Mazarei, Mitra; Turner, Geoffrey B.; Sykes, Robert W.; Decker, Stephen R.; Davis, Mark F.; Stewart, C. Neal

    2015-01-01

    The APETALA2/ethylene response factor (AP2/ERF) superfamily of transcription factors (TFs) plays essential roles in the regulation of various growth and developmental programs including stress responses. Members of these TFs in other plant species have been implicated to play a role in the regulation of cell wall biosynthesis. Here, we identified a total of 207 AP2/ERF TF genes in the switchgrass genome and grouped into four gene families comprised of 25 AP2-, 121 ERF-, 55 DREB (dehydration responsive element binding)-, and 5 RAV (related to API3/VP) genes, as well as a singleton gene not fitting any of the above families. The ERF and DREB subfamilies comprised seven and four distinct groups, respectively. Analysis of exon/intron structures of switchgrass AP2/ERF genes showed high diversity in the distribution of introns in AP2 genes versus a single or no intron in most genes in the ERF and RAV families. The majority of the subfamilies or groups within it were characterized by the presence of one or more specific conserved protein motifs. In silico functional analysis revealed that many genes in these families might be associated with the regulation of responses to environmental stimuli via transcriptional regulation of the response genes. Moreover, these genes had diverse endogenous expression patterns in switchgrass during seed germination, vegetative growth, flower development, and seed formation. Interestingly, several members of the ERF and DREB families were found to be highly expressed in plant tissues where active lignification occurs. These results provide vital resources to select candidate genes to potentially impart tolerance to environmental stress as well as reduced recalcitrance. Overexpression of one of the ERF genes (PvERF001) in switchgrass was associated with increased biomass yield and sugar release efficiency in transgenic lines, exemplifying the potential of these TFs in the development of lignocellulosic feedstocks with improved biomass characteristics for biofuels. PMID:26258121

  4. Phenomena identification and ranking tables for Westinghouse AP600 small break loss-of-coolant accident, main steam line break, and steam generator tube rupture scenarios

    SciTech Connect

    Wilson, G.E.; Fletcher, C.D.; Davis, C.B.

    1997-06-01

    This report revision incorporates new experimental evidence regarding AP600 behavior during small break loss-of-coolant accidents. This report documents the results of Phenomena Identification and Ranking Table (PIRT) efforts for the Westinghouse AP600 reactor. The purpose of this PIRT is to identify important phenomena so that they may be addressed in both the experimental programs and the RELAP5/MOD3 systems analysis computer code. In Revision of this report, the responses of AP600 during small break loss-of-coolant accident, main steam line break, and steam generator tube rupture accident scenarios were evaluated by a committee of thermal-hydraulic experts. Committee membership included Idaho National Engineering and Environmental Laboratory staff and recognized thermal-hydraulic experts from outside of the laboratory. Each of the accident scenarios was subdivided into separate, sequential periods or phases. Within each phase, the plant behavior is controlled by, at most, a few thermal-hydraulic processes. The committee identified the phenomena influencing those processes, and ranked & influences as being of high, medium, low, or insignificant importance. The primary product of this effort is a series of tables, one for each phase of each accident scenario, describing the thermal-hydraulic phenomena judged by the committee to be important, and the relative ranking of that importance. The rationales for the phenomena selected and their rankings are provided. This document issue incorporates an update of the small break loss-of-coolant accident portion of the report. This revision is the result of the release of experimental evidence from AP600-related integral test facilities (ROSA/AP600, OSU, and SPES) and thermal-hydraulic expert review. The activities associated with this update were performed during the period from June 1995 through November 1996. 8 refs., 26 figs., 42 tabs.

  5. Implementation and Initial Validation of the APS English Test [and] The APS English-Writing Test at Golden West College: Evidence for Predictive Validity.

    ERIC Educational Resources Information Center

    Isonio, Steven

    In May 1991, Golden West College (California) conducted a validation study of the English portion of the Assessment and Placement Services for Community Colleges (APS), followed by a predictive validity study in July 1991. The initial study was designed to aid in the implementation of the new test at GWC by comparing data on APS use at other…

  6. Draft Genome Sequences of Clinical Daptomycin-Nonsusceptible Methicillin-Resistant Staphylococcus aureus (MRSA) Strain APS211 and Its Daptomycin-Susceptible Progenitor APS210

    PubMed Central

    Cameron, David R.; Jiang, Jhih-Hang; Abbott, Iain J.; Spelman, Denis W.

    2015-01-01

    To assess the genetic factors contributing to daptomycin resistance in Staphylococcus aureus, the draft genome of a clinically derived daptomycin-nonsusceptible isolate APS211 was generated and compared to the draft sequence of its susceptible progenitor strain APS210. Four genetic differences were identified including a previously described mutation within the mprF gene. PMID:26067951

  7. ESM Computer Replacement Policy for Staff and A/P Faculty Purpose: To ensure that staff and A/P faculty have access to a computer that has

    E-print Network

    Dudek, Daniel M.

    ESM Computer Replacement Policy for Staff and A/P Faculty Purpose: To ensure that staff and A/P faculty have access to a computer that has sufficient capacity to support the basic computing needs not eligible for a computer provided through other university outlets, such as the ACC Banner or the Faculty

  8. The effects of temperature on vesicular supply and release in autaptic cultures of rat and mouse hippocampal neurons.

    PubMed

    Pyott, Sonja J; Rosenmund, Christian

    2002-03-01

    Membrane fusion plays a central role in the synaptic vesicle cycle. While many of the pre- and postfusion events have been investigated at room temperature, few researchers have investigated these processes at more physiologically relevant temperatures. We have used autaptic cultures of hippocampal neurons to investigate changes in the size and refilling rate of the readily releasable pool (RRP) of synaptic vesicles brought about by an increase in temperature from 25 to 35 degrees C. We have also examined temperature-dependent changes in spontaneous and action potential (AP)-evoked release as well as the fraction of the RRP that is released during an AP. Although we found a threefold increase in the refilling rate of the RRP at the higher temperature, there was no apparent change in the size of the RRP with increased temperature. Moreover, we observed a slight but significant decrease in the quanta released during an AP. This increased refilling rate and decreased release probability resulted in a reduction of both the degree and time course of synaptic depression during high frequency stimulation at the higher temperature. This reduction in synaptic depression was accompanied by an increased maintenance of the synchronous component of release during high frequency stimulation. These findings indicate that the dynamics of vesicular supply and release in hippocampal neurons at room temperature are significantly different at near physiological temperatures and could affect our present understanding of the way in which individual neurons and networks of neurons process information. PMID:11882684

  9. Phenelzine treatment increases transcription factor AP-2 levels in rat brain

    PubMed Central

    Damberg, Mattias; Berggård, Cecilia; Oreland, Lars

    2003-01-01

    Background The elevations of noradrenaline (NA) and serotonin (5-HT) levels in response to acute serotonin reuptake inhibitor (SSRI) or tricyclic antidepressant (TCA) exposure are not consistent with the time course for the therapeutic action of these antidepressants. Thus, neuronal adaptations are needed for the therapeutic effect to arise. Transcription factor Activating Protein –2 (AP-2) is critical for mammalian neural gene expression. Several genes involved in brainstem CNS transmitter systems, especially the monoamines, have AP-2 binding sites in their regulatory regions. We have previously shown that treatment with citalopram and imipramin resulted in a decrease in AP-2? and AP-2? levels in rat brain. We have also reported an association between a specific genotype of AP-2? to personality traits, binge-eating disorder and platelet monoamine oxidase (MAO) activity. Results Subchronic administration (10 days) of phenelzine (PLZ) increased the levels of AP-2?, AP-2? and the DNA binding activity of AP-2 in nuclear extracts prepared from rat whole brain when compared with sham treated animals. Conclusion These data suggest that AP-2 is not involved in the theraputic effect of antidepressants. Rather, the effects of antidepressants seen on the levels of AP-2 might be involved in the expression of side-effects during the lag-period. PMID:12943557

  10. Isolation and characterization of diadenosine tetraphosphate (Ap4A) hydrolase from Schizosaccharomyces pombe.

    PubMed

    Robinson, A K; de la Peña, C E; Barnes, L D

    1993-02-13

    An enzyme that catalyzes the asymmetric hydrolysis of Ap4A has been partially purified from the fission yeast, Schizosaccharomyces pombe. The crude supernatant fraction from log-phase cells was fractionated by (NH4)2SO4 precipitation followed by chromatography on DEAE-cellulose, Red A dye-ligand and QAE-Sepharose resins. Two peaks of Ap4A hydrolase activity, designated major and minor, were separated on the Red A dye-ligand resin. Both the major and minor Ap4A hydrolase have an apparent molecular mass of 49 kDa based on gel filtration chromatography. On a SDS polyacrylamide gel, a protein of 22 kDa exhibited Ap4A hydrolase activity. Both forms of the enzyme have a Km value in the range of 22 to 36 microM for Ap4A. Both forms of the enzyme asymmetrically hydrolyze Ap4A to AMP and ATP as determined by HPLC. Ap4A is the optimal substrate among several nucleotides and dinucleoside polyphosphates tested at 10 microM. A divalent metal cation is required for activity. Concentrations of Pi below 30 mM stimulate Ap4A hydrolase while higher concentrations inhibit the activity. Pi is not a substrate for this Ap4A-degradative enzyme. Fluoride, from 50 microM to 20 mM, has no significant effect on Ap4A hydrolase activity. PMID:8381667

  11. Replacing the Axial Ligand Tyrosine 75 or Its Hydrogen Bond Partner Histidine 83 Minimally Affects Hemin Acquisition by the Hemophore HasAp from Pseudomonas aeruginosa

    PubMed Central

    2015-01-01

    Hemophores from Pseudomonas aeruginosa (HasAp), Serratia marcescens (HasAsm), and Yersinia pestis (HasAyp) bind hemin between two loops. One of the loops harbors conserved axial ligand Tyr75 (Y75 loop) in all three structures, whereas the second loop (H32 loop) contains axial ligand His32 in HasAp and HasAsm, but a noncoordinating Gln32 in HasAyp. Binding of hemin to the Y75 loop of HasAp or HasAsm causes a large rearrangement of the H32 loop that allows His32 coordination. The Q32 loop in apo-HasAyp is already in the closed conformation, such that binding of hemin to the conserved Y75 loop occurs with minimal structural rearrangement and without coordinative interaction with the Q32 loop. In this study, structural and spectroscopic investigations of the hemophore HasAp were conducted to probe (i) the role of the conserved Tyr75 loop in hemin binding and (ii) the proposed requirement of the His83–Tyr75 hydrogen bond to allow the coordination of hemin by Tyr75. High-resolution crystal structures of H83A holo-HasAp obtained at pH 6.5 (0.89 Å) and pH 5.4 (1.25 Å) show that Tyr75 remains coordinated to the heme iron, and that a water molecule can substitute for N? of His83 to interact with the O? atom of Tyr75, likely stabilizing the Tyr75–Fe interaction. Nuclear magnetic resonance spectroscopy revealed that in apo-Y75A and apo-H83A HasAp, the Y75 loop is disordered, and that disorder propagates to nearby elements of secondary structure, suggesting that His83 N?–Tyr75 O? interaction is important to the organization of the Y75 loop in apo-HasA. Kinetic analysis of hemin loading conducted via stopped-flow UV–vis and rapid-freeze-quench resonance Raman shows that both mutants load hemin with biphasic kinetic parameters that are not significantly dissimilar from those previously observed for wild-type HasAp. When the structural and kinetic data are taken together, a tentative model emerges, which suggests that HasA hemophores utilize hydrophobic, ?–? stacking, and van der Waals interactions to load hemin efficiently, while axial ligation likely functions to slow hemin release, thus allowing the hemophore to meet the challenge of capturing hemin under inhospitable conditions and delivering it selectively to its cognate receptor. PMID:24625274

  12. RAD51AP2, a novel vertebrate- and meiotic-specific protein, sharesa conserved RAD51-interacting C-terminal domain with RAD51AP1/PIR51

    SciTech Connect

    Kovalenko, Oleg V.; Wiese, Claudia; Schild, David

    2006-07-25

    Many interacting proteins regulate and/or assist the activities of RAD51, a recombinase which plays a critical role in both DNA repair and meiotic recombination. Yeast two-hybrid screening of a human testis cDNA library revealed a new protein, RAD51AP2 (RAD51 Associated Protein 2), that interacts strongly with RAD51. A full-length cDNA clone predicts a novel vertebrate specific protein of 1159 residues, and the RAD51AP2 transcript was observed only in meiotic tissue (i.e. adult testis and fetal ovary), suggesting a meiotic-specific function for RAD51AP2. In HEK293 cells the interaction of RAD51 with an ectopically-expressed recombinant large fragment of RAD51AP2 requires the C-terminal 57 residues of RAD51AP2. This RAD51-binding region shows 81% homology to the C-terminus of RAD51AP1/PIR51, an otherwise totally unrelated RAD51-binding partner that is ubiquitously expressed. Analyses using truncations and point mutations in both RAD51AP1 and RAD51AP2 demonstrate that these proteins use the same structural motif for RAD51 binding. RAD54 shares some homology with this RAD51-binding motif, but this homologous region plays only an accessory role to the adjacent main RAD51-interacting region, which has been narrowed here to 40 amino acids. A novel protein, RAD51AP2, has been discovered that interacts with RAD51 through a C-terminal motif also present in RAD51AP1.

  13. The Alzheimer's disease risk factor CD2AP maintains blood-brain barrier integrity.

    PubMed

    Cochran, J Nicholas; Rush, Travis; Buckingham, Susan C; Roberson, Erik D

    2015-12-01

    CD2-associated protein (CD2AP) is a leading genetic risk factor for Alzheimer's disease, but little is known about the function of CD2AP in the brain. We studied CD2AP(-/-) mice to address this question. Because CD2AP(-/-) mice normally die by 6 weeks from nephrotic syndrome, we used mice that also express a CD2AP transgene in the kidney, but not brain, to attenuate this phenotype. CD2AP-deficient mice had no behavioral abnormalities except for mild motor and anxiety deficits in a subset of CD2AP(-/-) mice exhibiting severe nephrotic syndrome, associated with systemic illness. Pentylenetetrazol (PTZ)-induced seizures occurred with shorter latency in CD2AP(-/-) mice, but characteristics of these seizures on electroencephalography were not altered. As CD2AP is expressed in brain-adjacent endothelial cells, we hypothesized that the shorter latency to seizures without detectably different seizure characteristics may be due to increased penetration of PTZ related to compromised blood-brain barrier integrity. Using sodium fluorescein extravasation, we found that CD2AP(-/-) mice had reduced blood-brain barrier integrity. Neither seizure severity nor blood-brain barrier integrity was correlated with nephrotic syndrome, indicating that these effects are dissociable from the systemic illness associated with CD2AP deficiency. Confirming this dissociation, wild-type mice with induced nephrotic syndrome maintained an intact blood-brain barrier. Taken together, our results support a role of CD2AP in mediating blood-brain barrier integrity and suggest that cerebrovascular roles of CD2AP could contribute to its effects on Alzheimer's disease risk. PMID:26358779

  14. Role of ubiquitin and the HPV E6 oncoprotein in E6AP-mediated ubiquitination.

    PubMed

    Mortensen, Franziska; Schneider, Daniel; Barbic, Tanja; Sladewska-Marquardt, Anna; Kühnle, Simone; Marx, Andreas; Scheffner, Martin

    2015-08-11

    Deregulation of the ubiquitin ligase E6 associated protein (E6AP) encoded by the UBE3A gene has been associated with three different clinical pictures. Hijacking of E6AP by the E6 oncoprotein of distinct human papillomaviruses (HPV) contributes to the development of cervical cancer, whereas loss of E6AP expression or function is the cause of Angelman syndrome, a neurodevelopmental disorder, and increased expression of E6AP has been involved in autism spectrum disorders. Although these observations indicate that the activity of E6AP has to be tightly controlled, only little is known about how E6AP is regulated at the posttranslational level. Here, we provide evidence that the hydrophobic patch of ubiquitin comprising Leu-8 and Ile-44 is important for E6AP-mediated ubiquitination, whereas it does not affect the catalytic properties of the isolated catalytic HECT domain of E6AP. Furthermore, we show that the HPV E6 oncoprotein rescues the disability of full-length E6AP to use a respective hydrophobic patch mutant of ubiquitin for ubiquitination and that it stimulates E6AP-mediated ubiquitination of Ring1B, a known substrate of E6AP, in vitro and in cells. Based on these data, we propose that E6AP exists in at least two different states, an active and a less active or latent one, and that the activity of E6AP is controlled by noncovalent interactions with ubiquitin and allosteric activators such as the HPV E6 oncoprotein. PMID:26216987

  15. Overexpression of the transcription factor AP37 in rice improves grain yield under drought conditions.

    PubMed

    Oh, Se-Jun; Kim, Youn Shic; Kwon, Chang-Woo; Park, Hye Kyong; Jeong, Jin Seo; Kim, Ju-Kon

    2009-07-01

    Transcription factors with an APETELA2 (AP2) domain have been implicated in various cellular processes involved in plant development and stress responses. Of the 139 AP2 genes predicted in rice (Oryza sativa), we identified 42 genes in our current study that are induced by one or more stress conditions, including drought, high salinity, low temperature, and abscisic acid. Phylogenic analysis of these 42 stress-inducible AP2 genes revealed the presence of six subgroups (I-VI) with distinct signature motifs. Two genes, AP37 and AP59, representing subgroups I and II, respectively, were functionally characterized. Both genes were found to be induced upon 2 h of exposure to drought and high-salinity conditions but to differ in their expression profile upon exposure to low temperature and abscisic acid. The overexpression of AP37 and AP59 in rice under the control of the constitutive promoter OsCc1 increased the tolerance to drought and high salinity at the vegetative stage. Increased tolerance to low temperatures was observed only in OsCc1:AP37 plants. More importantly, the OsCc1:AP37 plants showed significantly enhanced drought tolerance in the field, which increased grain yield by 16% to 57% over controls under severe drought conditions, yet exhibited no significant difference under normal growth conditions. In contrast, grain yield in OsCc1:AP59 plants in the field was reduced by 23% to 43% compared with controls under both normal and drought stress conditions. Microarray experiments identified 10 and 38 genes that are up-regulated by AP37 and AP59, respectively, in addition to 37 genes that are commonly induced by both factors. Our results suggest that the AP37 gene has the potential to improve drought tolerance in rice without causing undesirable growth phenotypes. PMID:19429605

  16. Graphic Arts: Book Three. The Press and Related Processes.

    ERIC Educational Resources Information Center

    Farajollahi, Karim; And Others

    The third of a three-volume set of instructional materials for a graphic arts course, this manual consists of nine instructional units dealing with presses and related processes. Covered in the units are basic press fundamentals, offset press systems, offset press operating procedures, offset inks and dampening chemistry, preventive maintenance…

  17. Surface wave attenuation characteristics at the APS site

    SciTech Connect

    Jendrzejczyk, J.A.; Wambsganss, M.W.; Smith, R.K.

    1992-05-01

    During operation of the Advanced Photon Source (APS) Facility, there will be many potential sources of vibration that may be transmitted through the ground to the storage ring basement and experimental hall. These sources include chillers, pumps, blowers and fans. Some may produce amplitudes of sufficient magnitude to adversely affect the stability of the closed orbit of the beam. Where possible, these vibration sources will be monitored as they become operational, to determine their vibrational characteristics, such as amplitude and frequency, and duty cycle. Vibrations travel through the ground as body [compression (P) and shear (S)] waves and Rayleigh (R) waves, which are surface waves. The amplitudes of these waves decrease with distance from their source as a result of both geometric and material damping. Because the storage ring basement is {open_quotes}on grade{close_quotes}, the authors are primarily interested in waves on the surface. The R-waves, being surface waves, attenuate with distance more slowly than the body waves; for an R-wave, attenuation is proportional to 1/{radical}r, whereas for a body wave at the surface, attenuation is proportional to 1/r{sup 2}, where r is the distance from the source. Because R-waves attenuate more slowly, they are of primary interest relative to the isolation of vibration-sensitive facilities such as the APS. Measurement of surface wave attenuation requires a vibration source that is capable of producing a ground displacement level considerably greater than that of the ambient background. A pile driver that was used to drive steel pilings at the APS vehicle tunnel provided such a source. This study provides a measure of the attenuation of surface waves in the ground by the combination of geometric and material damping. An average coefficient of attenuation of 0.003 was derived from measured responses to vibrations provided by a pile driver.

  18. Higher-order modes in the APS storage ring waveguides

    SciTech Connect

    Brauer, S.O.; Kustom, R.L.

    1993-07-01

    Twelve higher-order modes (HOMs) in the single-cell accelerating cavities for the Advanced Photon Source (APS) storage ring were calculated to have complex impedances that will cause coupled-bunched instabilities near or below the 300mA positron current which is the design goal. Some of these modes couple, through the coupling loop, from the storage ring cavity into the waveguide. This study investigates the transmission of these modes from the cavity into the waveguide. The standing wave ratio (VSWR) of a WR2300 hybrid waveguide component has been measured at each HOM frequency, and its effect on the transmitted modes in the waveguide is studied.

  19. Abort interlock diagnostic for protection of APS vacuum chamber

    SciTech Connect

    Decker, G.

    1993-01-01

    The Advanced Photon Source (APS) vacuum system has been designed to be passively safe from bending magnet radiation heating at positron beam currents up to 30 mA. Above this value, certain components may be damaged from vertical beam missteering, although work is proceeding to raise the safe current threshold. Because of this, a system for preventing the misalignment of high power density beams is required. This report details a system for protection from dipole radiation only. Work on a system for ID radiation is continuing.

  20. Abort interlock diagnostic for protection of APS vacuum chamber

    SciTech Connect

    Decker, G.

    1993-06-01

    The Advanced Photon Source (APS) vacuum system has been designed to be passively safe from bending magnet radiation heating at positron beam currents up to 30 mA. Above this value, certain components may be damaged from vertical beam missteering, although work is proceeding to raise the safe current threshold. Because of this, a system for preventing the misalignment of high power density beams is required. This report details a system for protection from dipole radiation only. Work on a system for ID radiation is continuing.

  1. Initial diagnostics commissioning results for the Advanced Photon Source (APS)

    SciTech Connect

    Lumpkin, A.; Patterson, D.; Wang, X.

    1995-07-01

    Principal diagnostics systems have been installed and nearly all have been commissioned on the subsystems of the Advanced Photon Source (APS) facility. Data have been obtained on beam position, beam profile, current, beam loss rate, and synchrotron radiation monitors on both injector rings and most recently the main 7-GeV storage ring. Results for the 150- to 450-MeV electron beams in the accumulator ring, up to 7 GeV in the injector synchrotron, and 4.5 to 7 GeV in the SR will be presented.

  2. The APS transfer line from linac to injector synchrotron

    SciTech Connect

    Koul, R.K.; Crosbie, E.

    1991-03-01

    This note describes the low-energy-transfer-line designed for the APS. The low energy transfer line constitutes two transport lines. One of these lines runs from linac to the positron accumulator ring, also called ``PAR``, and is 23.7138 m long. The second part of the low energy transport line runs from the ``PAR`` to the injector synchrtoron and is about 30.919 m long. The above length includes two quadrupoles, a bend magnet and a septum magnet in the injector synchrotron.

  3. APS beamline standard components handbook, Version 1. 3

    SciTech Connect

    Hahn, U.; Shu, D.; Kuzay, T.M.

    1993-02-01

    This Handbook in its current version (1.3) contains descriptions, specifications, and preliminary engineering design drawings for many of the standard components. The design status and schedules have been provided wherever possible. In the near future, the APS plans to update engineering drawings of identified standard beamline components and complete the Handbook. The completed version of this Handbook will become available to both the CATs and potential vendors. Use of standard components should result in major cost reductions for CATs in the areas of beamline design and construction.

  4. STS-8 onboard crew press conference

    NASA Technical Reports Server (NTRS)

    1983-01-01

    Six news reporters listen to a response from Astronaut Guion S. Bluford (note TV monitor) in a rare space-to-Earth press conference involving all the STS-8 crew. The participants are, left to right, Gary Schwitzer, Cable News Network; Morton Dean, CBS; Roy Neal, NBC; Lynn Sherr, ABC; Howard Benedict, Associated Press; Al Rossiter, United Press International. The astronauts on the monitor are Richard H. Truly, cneter left, crew commander; Daniel C. Brandenstein, lower left, pilot; and Dr. William E. Thornton, upper left, Guion S. Bluford, upper right; and Dale E. Gardner, all mission specialists.

  5. CSA/ASC Press Briefing

    NASA Technical Reports Server (NTRS)

    2005-01-01

    Nicole Gignac, Senior Communications Advisor Canadian Space Agency (CSA), introduces the panel for this CSA/ASC press briefing. The panel consist of: Dr. Steve Maclean, CSA astronaut; Dr. Paul Cooper, Deputy General Manager, MacDonald, Dettwiler and Associates Ltd. (MDA); and Dr. Iain Christie, Director of Research and Development from NEPTEC. Maclean will fly on the STS-115 Mission in February of 2006. He presents pictures and talks about the crewmembers of the Space Shuttle Columbia and Space Shuttle Discovery. Maclean also discusses entry risks as it pertains to the leading edge wing of Discovery. Paul Cooper explains and shows a video presentation of Canadarm robotics. The briefing ends with Dr Christie explaining the sensitive three dimensional inspections are performed in space that looks for cracks in the leading edge wing of the Space Shuttle Discovery.

  6. ICFA Sardinia July 1-6, 2002 Z. Huang (zrh@aps.anl.gov) CSR Microbunching

    E-print Network

    ICFA Sardinia July 1-6, 2002 Z. Huang (zrh@aps.anl.gov) CSR Microbunching: Gain Calculation Zhirong Huang, Kwang-Je Kim Argonne National Laboratory #12;ICFA Sardinia July 1-6, 2002 Z. Huang (zrh@aps.anl.gov gain=bfinal/binitial, comment on initial conditions #12;ICFA Sardinia July 1-6, 2002 Z. Huang (zrh@aps.anl.gov

  7. Design and simulation of a novel APS star tracker

    NASA Astrophysics Data System (ADS)

    Wu, Feng; Shen, Weimin; Zhou, Jiankang; Chen, Xinhua

    2008-12-01

    Star trackers determine attitude by identifying stars imaged on the image sensor via an optical system whose performance is required to meet the star identification algorithm. The method to determine parameters of the optical system is proposed based on the identification algorithm. These parameters include focal length, aperture, and field of view (FOV). Aberration correction requirements are also analyzed. Pyramid identification algorithm utilized in this paper is investigated. Some improved approaches are presented for star map processing, onboard catalog organization and star identification. A link table construction is designed to save brightness from the programmed APS sensor which decreases data effectively and enhances the ability to calculate star positions in star maps. A method is developed to organize the onboard catalog which avoids searching and comparing similar star pairs but makes for rapid and unique identification. When performing star identification with Pyramid identification algorithm, only X brightest stars are chosen from star maps to acquire high signal to noise ratio and decrease spikes. Star number statistics is fulfilled all over the sky with any orientations by varying FOV and limited magnitude. Base on the requirement of the identification algorithm, parameters of the optical system are determined with the given STAR1000 APS sensor by analyzing their feasibility in optical design. According to these determined parameters, a star camera is designed. An onboard catalog on which star identification relies is produced. Star identification simulation is implemented. Simulation result proves that the designed system gets a satisfactory performance.

  8. Luteolin, a flavonoid, inhibits AP-1 activation by basophils

    SciTech Connect

    Hirano, Toru; Higa, Shinji; Arimitsu, Junsuke; Naka, Tetsuji; Ogata, Atsushi; Shima, Yoshihito; Fujimoto, Minoru; Yamadori, Tomoki; Ohkawara, Tomoharu; Kuwabara, Yusuke; Kawai, Mari; Matsuda, Hisashi; Yoshikawa, Masayuki; Maezaki, Naoyoshi; Tanaka, Tetsuaki; Kawase, Ichiro; Tanaka, Toshio . E-mail: ttanak@imed3.med.osaka-u.ac.jp

    2006-02-03

    Flavonoids including luteolin, apigenin, and fisetin are inhibitors of IL-4 synthesis and CD40 ligand expression by basophils. This study was done to search for compounds with greater inhibitory activity of IL-4 expression and to clarify the molecular mechanisms through which flavonoids inhibit their expression. Of the 37 flavonoids and related compounds examined, ayanin, luteolin, and apigenin were the strongest inhibitors of IL-4 production by purified basophils in response to anti-IgE antibody plus IL-3. Luteolin did not suppress Syk or Lyn phosphorylation in basophils, nor did suppress p54/46 SAPK/JNK, p38 MAPK, and p44/42 MAPK activation by a basophilic cell line, KU812 cells, stimulated with A23187 and PMA. However, luteolin did inhibit phosphorylation of c-Jun and DNA binding activity of AP-1 in nuclear lysates from stimulated KU812 cells. These results provide a fundamental structure of flavonoids for IL-4 inhibition and demonstrate a novel action of flavonoids that suppresses the activation of AP-1.

  9. Large break LOCA calculations for the AP600 design

    SciTech Connect

    Fisher, J.E.

    1992-01-01

    This paper presents the application of RELAP5 to the calculation of a Large Break (200% doubled-ended rupture) Loss-of-Colant-Accident (LBLOCA) at the reactor vessel inlet for the proposed Westinghouse AP600 design. A parametric calculation was also performed to determine effects of loss of a complete Emergency Core Cooling system (ECCS) train. These calculations were performed over the core blowdown, refill, and reflood phases of the LBLOCA and did not address long term cooling. RELAP5 was shown to be adequate for system response calculation over the period of interest. The passive safety systems were predicted to effectively mitigate the consequences of LBLOCAs; the calculations showed less severe thermal responses than for a current generation Pressurized Water Reactor (PWR) plant. The two primary differences between the AP600 design and a current generation plant that affect LBLOCA response are the lower core thermal power, which results in lower temperatures during the blowdown phase, and the long duration accumulator injection, which provides ample core inventory makeup for final quenching.

  10. Large break LOCA calculations for the AP600 design

    SciTech Connect

    Fisher, J.E.

    1992-08-01

    This paper presents the application of RELAP5 to the calculation of a Large Break (200% doubled-ended rupture) Loss-of-Colant-Accident (LBLOCA) at the reactor vessel inlet for the proposed Westinghouse AP600 design. A parametric calculation was also performed to determine effects of loss of a complete Emergency Core Cooling system (ECCS) train. These calculations were performed over the core blowdown, refill, and reflood phases of the LBLOCA and did not address long term cooling. RELAP5 was shown to be adequate for system response calculation over the period of interest. The passive safety systems were predicted to effectively mitigate the consequences of LBLOCAs; the calculations showed less severe thermal responses than for a current generation Pressurized Water Reactor (PWR) plant. The two primary differences between the AP600 design and a current generation plant that affect LBLOCA response are the lower core thermal power, which results in lower temperatures during the blowdown phase, and the long duration accumulator injection, which provides ample core inventory makeup for final quenching.

  11. Development of large and fast cmos aps cameras at latt

    NASA Astrophysics Data System (ADS)

    Beigbeder, F.; Bourrec, E.; Dupieux, M.; Delaigue, G.; Rondi, S.; Rieutord, M.; Meunier, N.; Roudier, T.

    Since 2004, at the Laboratoire d'Astrophysique de Toulouse Tarbes (LATT), we work with CMOS APS detectors, firstly to develop a large-field,high-resolution camera for the observation of the solar supergranulation, secondly to develop a fast camera for an adaptive optics test bench. In these two projects, we use detectors from FillFactory, now continued by Cypress Semiconductor Corporation: IBIS4-14000, IBIS-16000, LUPA-4000, 14 Mpixels, 16 Mpixels, 4 Mpixels respectively. The last one just reads in a 240 × 240 pixels window to obtain readout rate of 1000 Image/s. For these purposes we developed dedicated controllers to follow the high pixel rate and multi-output readout of this type of detectors. We also studied the characterization methods and measured the main parameters of these CMOS detectors to know their behaviour. Using these kinds of APS detectors in these two particular projects proves that we can already find niches to use CMOS detectors in astronomy taking advantage of their present specificities. Recent improvements like back illumination, noise reduction, should rapidly open news possibilities.

  12. Designing an artificial pancreas architecture: the AP@home experience.

    PubMed

    Lanzola, Giordano; Toffanin, Chiara; Di Palma, Federico; Del Favero, Simone; Magni, Lalo; Bellazzi, Riccardo

    2015-12-01

    The latest achievements in sensor technologies for blood glucose level monitoring, pump miniaturization for insulin delivery, and the availability of portable computing devices are paving the way toward the artificial pancreas as a treatment for diabetes patients. This device encompasses a controller unit that oversees the administration of insulin micro-boluses and continuously drives the pump based on blood glucose readings acquired in real time. In order to foster the research on the artificial pancreas and prepare for its adoption as a therapy, the European Union in 2010 funded the AP@home project, following a series of efforts already ongoing in the USA. This paper, authored by members of the AP@home consortium, reports on the technical issues concerning the design and implementation of an architecture supporting the exploitation of an artificial pancreas platform. First a PC-based platform was developed by the authors to prove the effectiveness and reliability of the algorithms responsible for insulin administration. A mobile-based one was then adopted to improve the comfort for the patients. Both platforms were tested on real patients, and a description of the goals, the achievements, and the major shortcomings that emerged during those trials is also reported in the paper. PMID:25430423

  13. The fundamental parameters of the roAp star ? Circini

    NASA Astrophysics Data System (ADS)

    Bruntt, H.; North, J. R.; Cunha, M.; Brandão, I. M.; Elkin, V. G.; Kurtz, D. W.; Davis, J.; Bedding, T. R.; Jacob, A. P.; Owens, S. M.; Robertson, J. G.; Tango, W. J.; Gameiro, J. F.; Ireland, M. J.; Tuthill, P. G.

    2008-06-01

    We have used the Sydney University Stellar Interferometer to measure the angular diameter of ? Cir. This is the first detailed interferometric study of a rapidly oscillating A (roAp) star, ? Cir being the brightest member of its class. We used the new and more accurate Hipparcos parallax to determine the radius to be 1.967 +/- 0.066Rsolar. We have constrained the bolometric flux from calibrated spectra to determine an effective temperature of 7420 +/- 170K. This is the first direct determination of the temperature of an roAp star. Our temperature is at the low end of previous estimates, which span over 1000 K and were based on either photometric indices or spectroscopic methods. In addition, we have analysed two high-quality spectra of ? Cir, obtained at different rotational phases and we find evidence for the presence of spots. In both spectra we find nearly solar abundances of C, O, Si, Ca and Fe, high abundance of Cr and Mn, while Co, Y, Nd and Eu are overabundant by about 1 dex. The results reported here provide important observational constraints for future studies of the atmospheric structure and pulsation of ? Cir. Based on observations with the Sydney University Stellar Interferometer at the Paul Wild Observatory, Narrabri (Australia) and observations collected at the European Southern Observatory, Paranal (Chile), as part of programmes 072.D-0138 and 077.D-0150. E-mail: bruntt@physics.usyd.edu.au

  14. The new AP Physics exams: Integrating qualitative and quantitative reasoning

    NASA Astrophysics Data System (ADS)

    Elby, Andrew

    2015-04-01

    When physics instructors and education researchers emphasize the importance of integrating qualitative and quantitative reasoning in problem solving, they usually mean using those types of reasoning serially and separately: first students should analyze the physical situation qualitatively/conceptually to figure out the relevant equations, then they should process those equations quantitatively to generate a solution, and finally they should use qualitative reasoning to check that answer for plausibility (Heller, Keith, & Anderson, 1992). The new AP Physics 1 and 2 exams will, of course, reward this approach to problem solving. But one kind of free response question will demand and reward a further integration of qualitative and quantitative reasoning, namely mathematical modeling and sense-making--inventing new equations to capture a physical situation and focusing on proportionalities, inverse proportionalities, and other functional relations to infer what the equation ``says'' about the physical world. In this talk, I discuss examples of these qualitative-quantitative translation questions, highlighting how they differ from both standard quantitative and standard qualitative questions. I then discuss the kinds of modeling activities that can help AP and college students develop these skills and habits of mind.

  15. Interplay between TAp73 Protein and Selected Activator Protein-1 (AP-1) Family Members Promotes AP-1 Target Gene Activation and Cellular Growth*

    PubMed Central

    Subramanian, Deepa; Bunjobpol, Wilawan; Sabapathy, Kanaga

    2015-01-01

    Unlike p53, which is mutated at a high rate in human cancers, its homologue p73 is not mutated but is often overexpressed, suggesting a possible context-dependent role in growth promotion. Previously, we have shown that co-expression of TAp73 with the proto-oncogene c-Jun can augment cellular growth and potentiate transactivation of activator protein (AP)-1 target genes such as cyclin D1. Here, we provide further mechanistic insights into the cooperative activity between these two transcription factors. Our data show that TAp73-mediated AP-1 target gene transactivation relies on c-Jun dimerization and requires the canonical AP-1 sites on target gene promoters. Interestingly, only selected members of the Fos family of proteins such as c-Fos and Fra1 were found to cooperate with TAp73 in a c-Jun-dependent manner to transactivate AP-1 target promoters. Inducible expression of TAp73 led to the recruitment of these Fos family members to the AP-1 target promoters on which TAp73 was found to be bound near the AP-1 site. Consistent with the binding of TAp73 and AP-1 members on the target promoters in a c-Jun-dependent manner, TAp73 was observed to physically interact with c-Jun specifically at the chromatin via its carboxyl-terminal region. Furthermore, co-expression of c-Fos or Fra1 was able to cooperate with TAp73 in potentiating cellular growth, similarly to c-Jun. These data together suggest that TAp73 plays a vital role in activation of AP-1 target genes via direct binding to c-Jun at the target promoters, leading to enhanced loading of other AP-1 family members, thereby leading to cellular growth. PMID:26018080

  16. Gas-driven filter pressing in magmas

    USGS Publications Warehouse

    Sisson, T.W.; Bacon, C.R.

    1999-01-01

    Most silicic and some mafic magmas expand via second boiling if they crystallize at depths of about 10 km or less. The buildup of gas pressure due to second boiling can be relieved by expulsion of melt out of the region of crystallization, and this process of gas-driven filter pressing assists the crystallization differentiation of magmas. For gas-driven filter pressing to be effective, the region of crystallization must inflate slowly relative to buildup of pressure and expulsion of melt These conditions are satisfied in undercooled magmatic inclusions and in thin sheets of primitive magma underplating cooler magma reservoirs. Gas-driven filter pressing thereby adds fractionated melt to magma bodies. Gas-driven filter pressing is probably the dominant process by which highly evolved melts segregate from crystal mush to form aplitic dikes in granitic plutons; this process could also account for the production of voluminous, crystal-poor rhyolites.

  17. Consolidation of thermites by pressing and sintering

    SciTech Connect

    Kelly, M.D.; Abney, L.D.

    1984-01-01

    Consolidated thermites can be used as chemical heat sources. Pressing and sintering, a power metallurgy technique, has been developed to consolidate thermite parts with uniform density, composition, and calorific output. These materials are safe to handle, machineable, and generate minimum gas pressure upon reaction. This technique consists of die pressing various compositions of blended thermite powders, then isostatic pressing the parts before sintering to ensure the uniform density of the thermite composites. Parts sintered at various temperatures were examined metallographically for compositional uniformity and to determine whether diffusion between the powders had occurred. Flexure and tensile strength values were obtained to determine the temperature range required to produce strong parts. The coordination of metallography and strength values for various compositions and sintering temperature resulted in data that were used to optimize the fabrication process. Consolidation of thermite by pressing and sintering was found to be a valid process for producing uniform, dense, strong thermite parts.

  18. Apollo 13 Facts [Post Flight Press Conference

    NASA Technical Reports Server (NTRS)

    2001-01-01

    The Apollo 13 astronauts, James Lovell, Jr., John Swigert, Jr., and Fred Haise, Jr., are seen during this post flight press conference. They describe their mission and answer questions from the audience.

  19. NOS1AP Functionally Associates with YAP To Regulate Hippo Signaling.

    PubMed

    Clattenburg, Leanne; Wigerius, Michael; Qi, Jiansong; Rainey, Jan K; Rourke, Jillian L; Muruganandan, Shanmugam; Sinal, Christopher J; Fawcett, James P

    2015-07-01

    Deregulation of cellular polarity proteins and their associated complexes leads to changes in cell migration and proliferation. The nitric oxide synthase 1 adaptor protein (NOS1AP) associates with the tumor suppressor protein Scribble to control cell migration and oncogenic transformation. However, how NOS1AP is linked to the cell signaling events that curb oncogenic progression has remained elusive. Here we identify several novel NOS1AP isoforms, NOS1APd, NOS1APe, and NOS1APf, with distinct cellular localizations. We show that isoforms with a membrane-interacting phosphotyrosine binding (PTB) domain can associate with Scribble and recognize acidic phospholipids. In a screen to identify novel binding proteins, we have discovered a complex consisting of NOS1AP and the transcriptional coactivator YAP linking NOS1AP to the Hippo signaling pathway. Silencing of NOS1AP reduces the phosphorylation of YAP and of the upstream kinase Lats1. Conversely, expression of NOS1AP promotes YAP and Lats1 phosphorylation, which correlates with reduced TEAD activity and restricted cell proliferation. Together, these data implicate a role for NOS1AP in the regulation of core Hippo signaling and are consistent with the idea that NOS1AP functions as a tumor suppressor. PMID:25918243

  20. AP-2? is a transcriptional regulator for determination of digit length in tetrapods.

    PubMed

    Seki, Ryohei; Kitajima, Keiichi; Matsubara, Haruka; Suzuki, Takayuki; Saito, Daisuke; Yokoyama, Hitoshi; Tamura, Koji

    2015-11-01

    The species-specific morphology of digits in the tetrapod limb, including the length and number of metacarpal, metatarsal, and phalangeal bones, suggests that a common developmental mechanism for digit formation is modified in a species-specific manner. Here, we examined the function of the AP-2? transcription factor in regulating digit length in the chicken autopod. Mutations in the gene encoding AP-2? are associated with Char syndrome, a human autosomal dominant disorder. Char syndrome patients exhibit autopod skeletal defects, including loss of phalanges and shortened fingers, suggestive of a function for AP-2? in normal digit development. The ectopic expression of two different dominant-negative forms of chick AP-2?, equivalent to mutant forms associated with human Char syndrome, in the developing chick hindlimb bud resulted in defective digit formation, including reductions in the number and length of phalanges and metatarsals. A detailed analysis of the AP-2? expression pattern in the limb bud indicated a correlation between the pattern/duration of AP-2? expression in the limb mesenchyme and digit length in three amniote species, the chicken, mouse and gecko. In addition, we found that AP-2? expression was downstream of Fgf signals from the apical ectodermal ridge, which is crucial in digit morphogenesis, and that excessive AP-2? function resulted in dysregulated digit length. Taken together, these results suggest that AP-2? functions as a novel transcriptional regulator for digit morphogenesis. PMID:26277217

  1. Obesity-Linked Homologues TfAP-2 and Twz Establish Meal Frequency in Drosophila melanogaster

    PubMed Central

    Williams, Michael J.; Goergen, Philip; Rajendran, Jayasimman; Zheleznyakova, Galina; Hägglund, Maria G.; Perland, Emelie; Bagchi, Sonchita; Kalogeropoulou, Argyro; Khan, Zaid; Fredriksson, Robert; Schiöth, Helgi B.

    2014-01-01

    In all animals managing the size of individual meals and frequency of feeding is crucial for metabolic homeostasis. In the current study we demonstrate that the noradrenalin analogue octopamine and the cholecystokinin (CCK) homologue Drosulfakinin (Dsk) function downstream of TfAP-2 and Tiwaz (Twz) to control the number of meals in adult flies. Loss of TfAP-2 or Twz in octopaminergic neurons increased the size of individual meals, while overexpression of TfAP-2 significantly decreased meal size and increased feeding frequency. Of note, our study reveals that TfAP-2 and Twz regulate octopamine signaling to initiate feeding; then octopamine, in a negative feedback loop, induces expression of Dsk to inhibit consummatory behavior. Intriguingly, we found that the mouse TfAP-2 and Twz homologues, AP-2? and Kctd15, co-localize in areas of the brain known to regulate feeding behavior and reward, and a proximity ligation assay (PLA) demonstrated that AP-2? and Kctd15 interact directly in a mouse hypothalamus-derived cell line. Finally, we show that in this mouse hypothalamic cell line AP-2? and Kctd15 directly interact with Ube2i, a mouse sumoylation enzyme, and that AP-2? may itself be sumoylated. Our study reveals how two obesity-linked homologues regulate metabolic homeostasis by modulating consummatory behavior. PMID:25187989

  2. Isolation, classification and transcription profiles of the AP2/ERF transcription factor superfamily in citrus.

    PubMed

    Xie, Xiu-lan; Shen, Shu-ling; Yin, Xue-ren; Xu, Qian; Sun, Chong-de; Grierson, Donald; Ferguson, Ian; Chen, Kun-song

    2014-07-01

    The AP2/ERF gene family encodes plant-specific transcription factors. In model plants, AP2/ERF genes have been shown to be expressed in response to developmental and environmental stimuli, and many function downstream of the ethylene, biotic, and abiotic stress signaling pathways. In citrus, ethylene is effective in regulation citrus fruit quality, such as degreening and aroma. However, information about the citrus AP2/ERF family is limited, and would enhance our understanding of fruit responses to environmental stress, fruit development and quality. CitAP2/ERF genes were isolated using the citrus genome database, and their expression patterns analyzed by real-time PCR using various orange organs and samples from a fruit developmental series. 126 sequences with homologies to AP2/ERF proteins were identified from the citrus genome, and, on the basis of their structure and sequence, assigned to the ERF family (102), AP2 family (18), RAV family (4) and Soloist (2). MEME motif analysis predicted the defining AP2/ERF domain and EAR repressor domains. Analysis of transcript accumulation in Citrus sinensis cv. 'Newhall' indicated that CitAP2/ERF genes show organ-specific and temporal expression, and provided a framework for understanding the transcriptional regulatory roles of AP2/ERF gene family members in citrus. Hierarchical cluster analysis and t tests identified regulators that potentially function during orange fruit growth and development. PMID:24566692

  3. May 1, 1989- A Critical Turning Point in the Cold Fusion Saga: APS, MIT and the Real Story

    NASA Astrophysics Data System (ADS)

    Mallove, Sc. D.; Eugene, F.; Chubb, Talbot

    2001-04-01

    As Chief Science Writer at the MIT News Office from 1987 through 1991, and as an engineer (MIT, S.B. 1969, S.M. 1970) familiar with heat measurements and the various other experiment claims, I was in a position to ascertain the true facts surrounding: the media and Press Conference events at MIT before and after May 1, 1989; the ill-fated calorimetric experiment performed by the MIT Plasma Fusion Center; and the MIT Administration's so-called investigation of this experiment. This activity led to wide-spread disparagement of the Fleischmann-Pons claims. A reconstruction of these events will be outlined, together with original supporting evidence that confirm that the "standard story" of how cold fusion was "debunked" at the May 1, 1989 APS meeting in Baltimore is not only wrong, but catastrophically so(Eugene Mallove, Fire from Ice: Searching for the Truth Behind the Cold Fusion Furor. (John Wiley & Sons, 1991))^,(Infinite Energy Magazine, Issue #24, March/April 1999, 10th Anniversary of Cold Fusion issue. (Includes time-lines and 55-page "MIT Special Report") ).

  4. Impression creep behavior of atmospheric plasma sprayed and hot pressed MoSi{sub 2}/Si{sub 3}N{sub 4}

    SciTech Connect

    Hollis, K.J.; Butt, D.P.; Castro, R.G.

    1997-09-01

    The use of MoSi{sub 2} as a high temperature oxidation resistant structural material is hindered by its poor elevated temperature creep resistance. The addition of second phase Si{sub 3}N{sub 4} holds promise for improving the creep properties of MoSi{sub 2} without decreasing oxidation resistance. The high temperature impression creep behavior of atmospheric plasma sprayed (APS) and hot pressed (HP) MoSi{sub 2}/Si{sub 3}N{sub 4} composites was investigated. Values for steady state creep rates, creep activation energies, and creep stress exponents were measured. Grain boundary sliding and splat sliding were found to be the dominant creep mechanisms for the APS samples while grain boundary sliding and plastic deformation were found to be the dominant creep mechanisms for the HP samples.

  5. Mechanisms of alkali metal release during biomass combustion

    SciTech Connect

    Dayton, D.C.; Milne, T.A.

    1995-12-31

    The conversion of biomass materials into electricity via combustion poses several technical and economic challenges. One of the more pressing technical challenges associated with biomass combustion is fouling and stagging in combustors. Accelerated fouling and stagging in current biomass combustion facilities has been linked to the alkali metal content of the fuel. Alkali metal release during biomass combustion causes significant problems in terms of severe fouling and stagging of heat transfer surfaces in boilers thus reducing efficiency, and in the worst case leads to unscheduled plant downtime. Future biomass to electricity facilities that will incorporate integrated combined cycle systems that use biomass combustion gases directly to drive an aeroderivative turbine will have even lower tolerances for alkali metal vapor release because accelerated erosion and corrosion of turbine blades results in shorter turbine lifetimes. The release of alkali metal vapors during biomass combustion was monitored using a direct sampling, molecular beam mass spectrometer.

  6. The flame structure of AP/HTPB sandwiches

    NASA Astrophysics Data System (ADS)

    Chorpening, Benjamin Todd

    2000-10-01

    Ultraviolet emission imaging experiments have been used to study the combustion of sandwiches of ammonium perchlorate (AP) and hydroxyl-terminated polybutadiene (HTPB) in nitrogen at pressures up to 32 atm, with binder layers from 50 to 450 mum in thickness. An ICCD camera system has been used to image the flame emission near 310 nm, and a backlighting technique has been developed that allows determination of the corresponding surface shape during combustion. The results indicate the AP/HTPB interface regression rate of IPDI cured samples undergoing low power (100W) laser-assisted deflagration is nearly independent of the binder thickness for binders thicker than 100 mum. The pressure exponent of the regression rate is 0.31 up to 15 atm, increasing with pressure from 15 to 32 atm. Two primary regimes of flame behavior have been identified: a split flame base regime which occurs with high Peclet and Damkohler numbers, and a merged flame base regime which occurs with low Peclet and Damkohler numbers. A secondary regime, exhibiting a "lifted" flame, occurs with low Damkohler numbers and high Peclet numbers. The ultraviolet flame emissions observed in the experiments show a correspondence with the fuel-rich region of the flame, as determined with a Schvab-Zeldovich model. This is reasonable since the primary sources of ultraviolet emission in the 305--315 nm region, electronically excited OH and the CO + O reaction, are dependent on fuel related species. The growth of the fuel-rich region with increasing Peclet number, predicted by the model, is qualitatively matched by the experimental results. The predicted shrinkage of the fuel-rich region when the binder layer is diluted with fine AP is also qualitatively matched by the experiments. Comparison of the experimental results with a single-reaction model with finite rate kinetics shows a weak qualitative agreement on the influence of Damkohler number. A large increase in Damkohler number (factor of 20) leads to a strong splitting of the calculated reaction zone and a splitting of the base of the high temperature region. This seems to correspond to the splitting of the ultraviolet emission flame base observed in the experiments.

  7. Mariner Mars 1971: Press kit

    NASA Technical Reports Server (NTRS)

    Mittauer, R. T.

    1971-01-01

    The news release describes the 1971 launches of Mariner 8 and 9 which were to be the first attempt by NASA to orbit another planet, Mars. Described are: (1) mission capsule; (2) planetary missions; (3) aiming zones; (4) the spacecraft; (5) scientific experiments to be performed; (6) Atlas Centaur launch vehicle; (7) launch operations; (8) tracking and data system and mission operations; and (9) Mariner Mars 71 team and subcontractors.

  8. AUPress: A Comparison of an Open Access University Press with Traditional Presses

    ERIC Educational Resources Information Center

    McGreal, Rory; Chen, Nian-Shing

    2011-01-01

    This study is a comparison of AUPress with three other traditional (non-open access) Canadian university presses. The analysis is based on the rankings that are correlated with book sales on Amazon.com and Amazon.ca. Statistical methods include the sampling of the sales ranking of randomly selected books from each press. The results of one-way…

  9. To be published in Behavioral and Brain Sciences (in press) Cambridge University Press 2003

    E-print Network

    Cosmides, Leda

    1 To be published in Behavioral and Brain Sciences (in press) © Cambridge University Press 2003.) To give and to give not: The behavioral ecology of human food transfers Michael Gurven Department introduces a framework for better understanding variation in sharing behavior across small-scale traditional

  10. HOT OFF THE PRESS www.rsc.org/npr | Natural Product Reports Hot off the press

    E-print Network

    Gates, Kent. S.

    HOT OFF THE PRESS www.rsc.org/npr | Natural Product Reports Hot off the press Robert A. Hill developments in bioorganic chemistry and novel natural products, such as the first naturally occurring an interest in the structure and biosynthesis of natural products and has been writing regular reviews

  11. Compressibility of gastroretentive pellets coated with Eudragit NE using a single-stroke and a rotary tablet press.

    PubMed

    ?unio, Rafa?; Sawicki, Wieslaw; Skocze?, Przemys?aw; Walentynowicz, Olga; Kubasik-Juraniec, Jolanta

    2008-01-01

    In this study, 15 kinds of powders with different compression mechanisms were used in the process of filling-binding substances in tablets with pellets. Applied substances possessed dominant brittle time-independent mechanism or time-dependent viscoplastic, viscoelastic mechanism of compression. Using 6 kN compression force in a single-stroke tablet press during 150 ms of compression, damage to the polymer film and pellet core was found in all formulations. As a result, the authors observed an increase of releasing rate of verapamil hydrochloride (VH). A larger contact area between powders and pellets and connected with this better protective properties were ensured by powders with time-independent compression mechanism (eg, D-sorbitol or D-mannitol). Unsymmetrically applied compression force was a reason for inconsistent densification and insufficient protection of the pellets. Taking into consideration the low rotation speed of the turret (10 rpm) in the rotary tablet press, the total compaction time was much longer than in the single-stroke tablet press. The compression time in the case of the rotary tablet press should be considered as the sum of the precompression (about 130 ms) and main compression (about 280 ms) phase times. Compression force applied by upper and lower punch in the precompression and main compression phase was affected uniformly on the pellets' surface, and when protected against fragmentation, allowed only some slight deformation. The powders in tablet formulation were fragmentized and rearranged independent of their compression mechanisms. It was found that the releasing rate of VH from pellets compressed by rotary tablet press with 6, 12, and 18 kN of compression force was similar to the releasing rate from uncompressed pellets. PMID:18649222

  12. A radial-velocity survey of Ap stars with HARPS. I. HD 42659: The discovery of the first spectroscopic binary around a rapidly oscillating Ap star

    NASA Astrophysics Data System (ADS)

    Hartmann, M.; Hatzes, A. P.

    2015-10-01

    Context. Chemically peculiar Ap stars are main-sequence stars of spectral type B8-F3 which show large overabundances of some chemical elements (e.g., Si, Sr, Cr), especially of rare-earth elements, compared to normal A-type stars. Furthermore, they have strong, global magnetic fields and low rotational velocities. Some Ap stars exhibit high-overtone, low-degree, non-radial p-mode pulsations with periods of 6-24 min and are called rapidly oscillating Ap (roAp) stars. Interestingly, no roAp star is known to be a spectroscopic binary (SB), while many non-oscillating Ap (noAp) stars are found in SB systems. Aims: The goal of this survey was to carry out a systematic search for sub-stellar and stellar companions around Ap stars. Methods: Between 2004 and 2009, we observed 65 chemically peculiar stars with the HARPS spectrograph at the 3.6-m telescope at the European Southern Observatory (La Silla, Chile). The radial-velocity (RV) measurements were obtained using a new software called HARPS-TERRA which is based on a least-squares matching of each individual spectrum to a high signal-to-noise ratio template for each star. Results: We find significant variability with a period of 93.2 days and a semi-amplitude of 11.85 km s-1 in the RVs of HD 42659, a star of our sample that belongs to the group of roAp stars. This variability is caused by a stellar companion with a minimum mass of 0.47 M? in a slightly eccentric (e = 0.146) orbit at a separation of 0.55 AU. Conclusions: This detection makes HD 42659 the first confirmed SB around a roAp star in a relatively close orbit. It shows that tidal interactions in binaries do not necessarily inhibit pulsations in Ap stars. Based on observations collected at the European Southern Observatory (La Silla, Chile) under programs 074.C-0102, 075.C-0234, 076.C-0073, 079.C-0170, 080.C-0032, and 082.C-0308.

  13. An AP-1 site in the nerve growth factor promoter is essential for 1, 25-dihydroxyvitamin D3-mediated nerve growth factor expression in osteoblasts.

    PubMed

    Veenstra, T D; Fahnestock, M; Kumar, R

    1998-04-28

    1,25-Dihydroxyvitamin D3 (1,25(OH)2D3), the active metabolite of vitamin D, induces nerve growth factor (NGF) synthesis in a variety of different cell lines. The mechanism by which 1,25(OH)2D3 induces NGF, however, is poorly understood. We used a series of full-length and truncated NGF promoter-human growth hormone (hGH) reporter gene plasmids to investigate the mechanism of 1,25(OH)2D3-induced NGF expression in osteoblasts. Untransfected rat osteosarcoma cells (ROS 17/2.8) treated with 1,25(OH)2D3 showed a 2-fold increase in NGF expression compared to control cells. ROS 17/2.8 osteosarcoma cells were transfected with the NGF-hGH reporter plasmids and treated with 10(-)8 M 1,25(OH)2D3. The full-length NGF promoter (-1800 to +120)-hGH reporter construct showed an approximately 2-fold increase in hGH release. Plasmids with successive 5'-deletions showed enhanced hGH expression in treated cells and control cells. A similar series of NGF promoter-hGH reporter gene constructs, lacking the AP-1 site located within the first intron of the NGF gene, were also transiently transfected into ROS 17/2.8 cells. When these cells were treated with the same dose of 1,25(OH)2D3, no increase in hGH expression was seen compared to control cells, demonstrating that this AP-1 site is essential for 1,25(OH)2D3-mediated NGF up-regulation. Since 1,25(OH)2D3 is known to activate the transcription of several genes through its interaction with the vitamin D receptor (VDR), we performed a series of gel electrophoretic mobility shift assays to determine if the VDR binds directly to the AP-1 sequence. No evidence of VDR binding, either as a homodimer or as a heterodimer, to the AP-1 sequence was observed. Treatment of ROS 17/2.8 cells with 1,25(OH)2D3, however, resulted in an increase in AP-1 binding activity; however, no significant changes in c-jun and c-fos levels were observed. Our data show that in osteoblasts, 1,25(OH)2D3 induces NGF expression indirectly by increasing AP-1 binding activity. PMID:9558335

  14. Kiln for hot-pressing compacts in a continuous manner

    DOEpatents

    Reynolds, Jr., Carl D. (Clinton, TN)

    1985-01-01

    The present invention is directed to a hot pressing furnace or kiln which is capable of preheating, hot pressing, and cooling a plurality of articles in a sequential and continuous manner. The hot pressing furnace of the present invention comprises an elongated, horizontally disposed furnace capable of holding a plurality of displaceable pusher plates each supporting a die body loaded with refractory or ceramic material to be hot pressed. Each of these plates and the die body supported thereby is sequentially pushed through the preheating zone, a temperature stabilizing and a hot pressing zone, and a cooling zone so as to provide a continuous hot-pressing operation of a plurality of articles.

  15. Kiln for hot-pressing compacts in a continuous manner

    DOEpatents

    Reynolds, C.D Jr.

    1983-08-08

    The invention is directed to a hot pressing furnace or kiln which is capable of preheating, hot pressing, and cooling a plurality of articles in a sequential and continuous manner. The hot pressing furnace of the present invention comprises an elongated, horizontally disposed furnace capable of holding a plurality of displaceable pusher plates each supporting a die body loaded with refractory or ceramic material to be hot pressed. Each of these plates and the die body supported thereby is sequentially pushed through the preheating zone, a temperature stabilizing and a hot pressing zone, and a cooling zone so as to provide a continuous hot-pressing operation of a plurality of articles.

  16. Global coupling and decoupling of the APS storage ring

    SciTech Connect

    Chae, Y.C.; Liu, J.; Teng, L.C.

    1993-07-01

    This paper describes a study of controlling the coupling between the horizontal and the vertical betatron oscillations in the 7-GeV Advanced Photon Source (APS) storage ring. First, we investigate the strengthening of coupling using two families of skew quadrupoles. Twenty skew quadrupoles are arranged in the 40 sectors of the storage ring and powered in such a way so as to generate both quadrature components of the required 21st harmonic. The numerical results from tracking a single particle are presented for the various configurations of skew quadrupoles. Second, we describe the global decoupling procedure to minimize the unwanted coupling effects. These are mainly due to the random roll errors of normal quadruples. It is shown that even with the rather large rms roll error of 2 mrad, the coupling effects can be compensated for with 20 skew quadrupoles each having maximum strength one order of magnitude lower than the typical normal quadrupole strength.

  17. Some considerations in the combustion of AP/composite propellants

    NASA Technical Reports Server (NTRS)

    Kumar, R. N.

    1972-01-01

    Theoretical studies are presented on the time-independent and oscillatory combustion of nonmetallized AP/composite propellants. Three hypotheses are introduced: (1) The extent of propellant degradation at the vaporization step has to be specified through a scientific criterion. (2) The condensed phase degradation reaction of ammonium perchlorate to a vaporizable state is the overall rate-limiting step. (3) Gas phase combustion rate is controlled by the mixing rate of fuel and oxidizer vapors. In the treatment of oscillatory combustion, the assumption of quasi-steady fluctuations in the gas phase is used to supplement these hypotheses. In comparison with experimental data, this study predicts several of the observations including a few that remain inconsistent with theoretical results.

  18. Nomenclature and name assignment rules for the APS storage ring

    SciTech Connect

    Decker, G.

    1992-03-16

    Because the APS accelerators are moving into the fabrication/assembly/installation stage, it is important for consistent naming conventions to be used throughout the project. The intent of this note is to dictate the rules to be adhered to when naming devices in the storage ring. These rules are generic in nature, and shall be applied in principle to the other machines as well. It is essential that every component have a unique and, hopefully, easily recognizable name. Every ASD and XFD group, except for magnets, must interface with the control system. For this reason all device names were developed keeping in mind their actual function, such as controlling or monitoring some device in the ring. Even though magnets are not directly interfaced to the control system, their power supplies are; therefore, a magnet will have the same name as its associated power supply.

  19. Hydrothermal waves in evaporating sessile drops (APS 2009)

    E-print Network

    Brutin, D; LeNiliot, C

    2009-01-01

    This fluid dynamics video was submitted to the Gallery of Fluid Motion for the 2009 APS Division of Fluid Dynamics Meeting in Minneapolis, Minnesota. Drop evaporation is a simple phenomena but still unclear concerning the mechanisms of evaporation. A common agreement of the scientific community based on experimental and numerical work evidences that most of the evaporation occurs at the triple line. However, the rate of evaporation is still empirically predicted due to the lack of knowledge on the convection cells which develop inside the drop under evaporation. The evaporation of sessile drop is more complicated than it appears due to the coupling by conduction with the heating substrate, the convection and conduction inside the drop and the convection and diffusion with the vapour phase. The coupling of heat transfer in the three phases induces complicated cases to solve even for numerical simulations. We present recent experimental fluid dynamics videos obtained using a FLIR SC-6000 coupled with a microsco...

  20. Fabrication and Testing of Deflecting Cavities for APS

    SciTech Connect

    Mammosser, John; Wang, Haipeng; Rimmer, Robert; Jim, Henry; Katherine, Wilson; Dhakal, Pashupati; Ali, Nassiri; Jim, Kerby; Jeremiah, Holzbauer; Genfa, Wu; Joel, Fuerst; Yawei, Yang; Zenghai, Li

    2013-09-01

    Jefferson Lab (Newport News, Virginia) in collaboration with Argonne National Laboratory (Argonne, IL) has fabricated and tested four first article, 2.8 GHz, deflecting SRF cavities, for Argonne's Short-Pulse X-ray (SPX) project. These cavities are unique in many ways including the fabrication techniques in which the cavity cell and waveguides were fabricated. These cavity subcomponents were milled from bulk large grain niobium ingot material directly from 3D CAD files. No forming of sub components was used with the exception of the beam-pipes. The challenging cavity and helium vessel design and fabrication results from the stringent RF performance requirements required by the project and operation in the APS ring. Production challenges and fabrication techniques as well as testing results will be discussed in this paper.

  1. The APS intranet as a man-machine interface.

    SciTech Connect

    Ciarlette, D.; Gerig, R.; McDowell, W.

    1997-12-02

    The Advanced Photon Source at Argonne National Laboratory has implemented a number of methods for people to interact with the accelerator systems. The accelerator operators use Sun workstations running MEDM and WCL to interface interactively with the accelerator, however, many people need to view information rather than interact with the machine. One of the most common interfaces for viewing information at the Advanced Photon Source is the World Wide Web. Information such as operations logbook entries, machine status updates, and displays of archived and current data are easily available to APS personnel. This interface between people and the accelerator has proven to be quite useful. Because the Intranet is operating-system independent and inherently unidirectional, ensuring the prevention of unauthorized or accidental control of the accelerators is straightforward.

  2. Aerosol Polarimetry Sensor (APS): Design Summary, Performance and Potential Modifications

    NASA Technical Reports Server (NTRS)

    Cairns, Brian

    2014-01-01

    APS is a mature design that has already been built and has a TRL of 7. Algorithmic and retrieval capabilities continue to improve and make better and more sophisticated used of the data. Adjoint solutions, both in one dimensional and three dimensional are computationally efficient and should be the preferred implementation for the calculation of Jacobians (one dimensional), or cost-function gradients (three dimensional). Adjoint solutions necessarily provide resolution of internal fields and simplify incorporation of active measurements in retrievals, which will be necessary for a future ACE mission. Its best to test these capabilities when you know the answer: OSSEs that are well constrained observationally provide the best place to test future multi-instrument platform capabilities and ensure capabilities will meet scientific needs.

  3. Klystron modulator operation and upgrades for the APS linac

    SciTech Connect

    Russell, T.J.; Cours, A.

    1995-07-01

    The Advanced Photon Source (APS) linac requires five 100-MW modulators to achieve its required energy. In-house construction of these modulators was under an extremely compressed time schedule and, while the original design was successful, it had a few shortcomings. The operation of the modulators was hindered by excessively sensitive controls and overheating during the hot summer months. The system underwent minor changes that resulted in major improvements. Additionally, improvements have been made to the high voltage circuits to improve the rise time of the output pulse shape. reduce the initial ringing of the pulse, and enhance the reliability of the system. This paper will outline the changes and explain the results of the improvements.

  4. The chemical abundances of the Ap star HD94660

    SciTech Connect

    Giarrusso, M.

    2014-05-09

    In this work I present the determination of chemical abundances of the Ap star HD94660, a possible rapid oscillating star. As all the magnetic chemically peculiar objects, it presents CNO underabundance and overabundance of iron peak elements of ?100 times and of rare earths up to 4 dex with respect to the Sun. The determination was based on the conversion of the observed equivalent widths into abundances simultaneously to the determination of effective temperature and gravity. Since the Balmer lines of early type stars are very sensitive to the surface gravity while the flux distribution is sensitive to the effective temperature, I have adopted an iterative procedure to match the H{sub ?} line profile and the observed UV-Vis-NIR magnitudes of HD94660 looking for a consistency between the metallicity of the atmosphere model and the derived abundances. From my spectroscopic analysis, this star belongs to the no-rapid oscillating class.

  5. Bacillusin A, an Antibacterial Macrodiolide from Bacillus amyloliquefaciens AP183.

    PubMed

    Ravu, Ranga Rao; Jacob, Melissa R; Chen, Xiaolong; Wang, Mei; Nasrin, Shamima; Kloepper, Joseph W; Liles, Mark R; Mead, David A; Khan, Ikhlas A; Li, Xing-Cong

    2015-04-24

    Bioassay-guided fractionation of the organic extracts of a Bacillus amyloliquefaciens strain (AP183) led to the discovery of a new macrocyclic polyene antibiotic, bacillusin A (1). Its structure was assigned by interpretation of NMR and MS spectroscopic data as a novel macrodiolide composed of dimeric 4-hydroxy-2-methoxy-6-alkenylbenzoic acid lactones with conjugated pentaene-hexahydroxy polyketide chains. Compound 1 showed potent antibacterial activities against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium with minimum inhibitory concentrations in a range of 0.6 to 1.2 ?g/mL. The biosynthetic significance of this unique class of antibiotic compounds is briefly discussed. PMID:25756620

  6. Improved temperature regulation of APS linac RF components.

    SciTech Connect

    Dortwegt, R.

    1998-09-21

    The temperature of the APS S-Band linac's high-power rf components is regulated by water from individual closed-loop deionized (DI) water systems. The rf components are all made of oxygen-free high-conductivity copper and respond quickly to temperature changes. The SLED cavities are especially temperature-sensitive and cause beam energy instabilities when the temperature is not well regulated. Temperature regulation better than {+-} 0.1 F is required to achieve good energy stability. Improvements in the closed-loop water systems have enabled them to achieve a regulation of {+-} 0.05 F over long periods. Regulation philosophy and equipment are discussed and numerical results are presented.

  7. Press fit design : force and torque testing of steel dowel pins in brass and nylon samples

    E-print Network

    Nelson, Alexandra T

    2006-01-01

    An experimental study was conducted to determine the accuracy of current press fit theory when applied to press fit design. Brass and nylon hex samples were press fitted with hardened steel dowel pins. Press fit force and ...

  8. Growth and Achievement Trends of Advanced Placement (AP) Exams in American High Schools

    ERIC Educational Resources Information Center

    Judson, Eugene; Hobson, Angela

    2015-01-01

    This exploratory study examined and compared overall trends in growth and student achievement of the Advanced Placement (AP) program. Using data from the past two decades, analyses indicated there has been steady and extensive growth of AP participation, particularly among underclassmen and some minority groups. However, overall achievement, as…

  9. SYLLABUS -aps1014h ADVANCED PROJECT MANAGEMENT saved 2015-01-20

    E-print Network

    Toronto, University of

    SYLLABUS - aps1014h ADVANCED PROJECT MANAGEMENT saved 2015-01-20 Instructor: Keith Farndale (keith.farndale@utoronto.ca) Prerequisite: aps1001 Project Management, and equivalent of at least 1 year full-time working experience and tools which is easy to talk about and to "learn" in theory. What makes project management more "advanced

  10. Environmental and Sustainable Technology Evaluation: Mold-Resistant Armacell Insulation--Armacell LLC, AP Armaflex Black

    EPA Science Inventory

    The ESTE test program measured the mold resistance of Armacell AP Armaflex Black insulation. Tests for emissions of VOCs and formaldehyde were also performed. AP Armaflex Roll Insulation is a black flexible closed-cell, fiber-free elastomeric thermal insulation. The expanded clos...

  11. The 8th Annual AP[R] Report to the Nation

    ERIC Educational Resources Information Center

    College Board, 2012

    2012-01-01

    In classrooms around the country, AP (Advanced Placement) teachers are preparing students for tomorrow by teaching them how to think and learn today. AP students learn to construct solid arguments, test theories, and see many sides of an issue--the kind of thinking that solves tough problems both in and outside the classroom, in college and…

  12. Coming Soon: CADRE (Career Advancement and Development Resources and Education) website for all APS members

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The Council of the American Phytopathological Society (APS) approved an initiative in February 2013 to create a web resource called CADRE (Career Advancement and Development Resources and Education). CADRE is to provide APS members an archive of articles, videos, and webinars about a variety of prof...

  13. Validating the Use of AP® Exam Scores for College Course Placement. Research Report 2013-2

    ERIC Educational Resources Information Center

    Patterson, Brian F.; Ewing, Maureen

    2013-01-01

    The Advanced Placement Program® (AP®) was created to provide access to rigorous, college-level curricula to motivated and prepared high school students. This study evaluated whether the AP Exam scores from the summative exams associated with 10 courses were valid for the placement of students into higher-level college courses in the subject area…

  14. Shape-selective recognition of DNA abasic sites by metallohelices: inhibition of human AP endonuclease 1

    PubMed Central

    Malina, Jaroslav; Scott, Peter; Brabec, Viktor

    2015-01-01

    Loss of a base in DNA leading to creation of an abasic (AP) site leaving a deoxyribose residue in the strand, is a frequent lesion that may occur spontaneously or under the action of various physical and chemical agents. Progress in the understanding of the chemistry and enzymology of abasic DNA largely relies upon the study of AP sites in synthetic duplexes. We report here on interactions of diastereomerically pure metallo–helical ‘flexicate’ complexes, bimetallic triple-stranded ferro-helicates [Fe2(NN-NN)3]4+ incorporating the common NN–NN bis(bidentate) helicand, with short DNA duplexes containing AP sites in different sequence contexts. The results show that the flexicates bind to AP sites in DNA duplexes in a shape-selective manner. They preferentially bind to AP sites flanked by purines on both sides and their binding is enhanced when a pyrimidine is placed in opposite orientation to the lesion. Notably, the ?-enantiomer binds to all tested AP sites with higher affinity than the ?-enantiomer. In addition, the binding of the flexicates to AP sites inhibits the activity of human AP endonuclease 1, which is as a valid anticancer drug target. Hence, this finding indicates the potential of utilizing well-defined metallo–helical complexes for cancer chemotherapy. PMID:25940617

  15. Mechanism of AP-1-mediated gene expression by select organochlorines through the p38 MAPK pathway

    E-print Network

    McLachlan, John

    -activators such as the p160s, which can directly bind nuclear hormone receptors like the estrogen receptor (ER) (3). AP-1 signaling by environmental chemicals associated with the estrogen receptor (ER) and more recently via ER) and its metabolites induce a stress mitogen-activated pro- tein kinase (MAPK) that leads to AP-1

  16. An Inquiry into Retention and Achievement Differences in Campus Based and Web Based AP Courses

    ERIC Educational Resources Information Center

    Barbour, Michael; Mulcahy, Dennis

    2006-01-01

    A decade ago the Advanced Placement (AP) program was introduced into the Canadian province of Newfoundland and Labrador. Initially, schools embraced this opportunity to provide their students with opportunities that were previously unavailable. However, within a few years the AP program was relegated to urban and large regional high schools. Few…

  17. Glutathione peroxidase-1 inhibits UVA-induced AP-2{alpha} expression in human keratinocytes

    SciTech Connect

    Yu Lei; Venkataraman, Sujatha; Coleman, Mitchell C.; Spitz, Douglas R.; Wertz, Philip W.; Domann, Frederick E. . E-mail: frederick-domann@uiowa.edu

    2006-12-29

    In this study, we found a role for H{sub 2}O{sub 2} in UVA-induced AP-2{alpha} expression in the HaCaT human keratinocyte cell line. UVA irradiation not only increased AP-2{alpha}, but also caused accumulation of H{sub 2}O{sub 2} in the cell culture media, and H{sub 2}O{sub 2} by itself could induce the expression of AP-2{alpha}. By catalyzing the removal of H{sub 2}O{sub 2} from cells through over-expression of GPx-1, induction of AP-2{alpha} expression by UVA was abolished. Induction of transcription factor AP-2{alpha} by UVA had been previously shown to be mediated through the second messenger ceramide. We found that not only UVA irradiation, but also H{sub 2}O{sub 2} by itself caused increases of ceramide in HaCaT cells, and C2-ceramide added to cells induced the AP-2{alpha} signaling pathway. Finally, forced expression of GPx-1 eliminated UVA-induced ceramide accumulation as well as AP-2{alpha} expression. Taken together, these findings suggest that GPx-1 inhibits UVA-induced AP-2{alpha} expression by suppressing the accumulation of H{sub 2}O{sub 2}.

  18. AP-42 ADDITIONS AND REVISIONS - INTEGRATED IRON AND STEEL INDUSTRY - STEEL MINI MILLS

    EPA Science Inventory

    This project develops emission factors, etc., for the integrated iron and steel industry which are incorporated into AP-42. AP-42 is a massive collection of information concerning processes which generate air emissions and presents emission factors and control effectiveness infor...

  19. 78 FR 19691 - Applications for New Awards; Advanced Placement (AP) Test Fee Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-02

    ... Applications for New Awards; Advanced Placement (AP) Test Fee Program AGENCY: Office of Elementary and Secondary Education, Department of Education. ACTION: Notice. Overview Information Advanced Placement Test... Announcement I. Funding Opportunity Description Purpose of Program: The AP Test Fee program awards grants...

  20. 77 FR 8848 - Application for New Awards; Advanced Placement (AP) Test Fee Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-15

    ... Application for New Awards; Advanced Placement (AP) Test Fee Program AGENCY: Office of Elementary and Secondary Education, Department of Education. ACTION: Notice. Overview Information: Advanced Placement Test.... Full Text of Announcement I. Funding Opportunity Description Purpose of Program: The AP Test...

  1. Transcriptional activation by Myc is under negative control by the transcription factor AP-2.

    PubMed Central

    Gaubatz, S; Imhof, A; Dosch, R; Werner, O; Mitchell, P; Buettner, R; Eilers, M

    1995-01-01

    The Myc protein binds to and transactivates the expression of genes via E-box elements containing a central CAC(G/A)TG sequence. The transcriptional activation function of Myc is required for its ability to induce cell cycle progression, cellular transformation and apoptosis. Here we show that transactivation by Myc is under negative control by the transcription factor AP-2. AP-2 inhibits transactivation by Myc via two distinct mechanisms. First, high affinity binding sites for AP-2 overlap Myc-response elements in two bona fide target genes of Myc, prothymosin-alpha and ornithine decarboxylase. On these sites, AP-2 competes for binding of either Myc/Max heterodimers or Max/Max homodimers. The second mechanism involves a specific interaction between C-terminal domains of AP-2 and the BR/HLH/LZ domain of Myc, but not Max or Mad. Binding of AP-2 to Myc does not preclude association of Myc with Max, but impairs DNA binding of the Myc/Max complex and inhibits transactivation by Myc even in the absence of an overlapping AP-2 binding site. Taken together, our data suggest that AP-2 acts as a negative regulator of transactivation by Myc. Images PMID:7729426

  2. Development of cotton gin PM2.5 emission factors for EPA’S AP-42

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The Compilation of Air Pollution Emission Factors (AP-42) emission factors are assigned ratings, from A (Excellent) to E (Poor), based on the quality of data used to develop them. AP-42 currently contains no PM2.5 cotton gin emission factors. In an effort to develop science-based data for regulating...

  3. The Rush to Take More AP Courses Hurts Students, High Schools, and Colleges

    ERIC Educational Resources Information Center

    Oxtoby, David W.

    2007-01-01

    In most schools, the rush toward Advanced Placement (AP) courses goes on unabated. In 2006 the number of students taking AP exams increased almost 10 percent over the preceding year. This is largely because of the growing intensity of the admissions game and the urge on the part of college applicants to seek out every advantage. In applying to…

  4. The Rush to Take More AP Courses Hurts Students, High Schools, and Colleges

    ERIC Educational Resources Information Center

    Oxtoby, David W.

    2007-01-01

    In most schools, the rush toward Advanced Placement (AP) courses goes on unabated. In 2006 the number of students taking AP exams increased almost 10 percent over the preceding year, according to the College Board. This is largely because of the growing intensity of the admissions game and the urge on the part of college applicants to seek out…

  5. AP-42 ADDITIONS AND REVISIONS - GRAIN LOADING ONTO SHIPS AND BARGES

    EPA Science Inventory

    This project develops emission factors, etc., for the grain shipping industry which are appended to AP-42. AP42 is a massive collection of material which describes processes which generate air emissions and presents emission factors and control effectiveness information. As reso...

  6. Understanding and Using the New Guided-Inquiry AP Chemistry Laboratory Manual

    ERIC Educational Resources Information Center

    Cacciatore, Kristen L.

    2014-01-01

    To support teaching and learning in the advanced placement (AP) chemistry laboratory, the College Board published a laboratory manual, "AP Chemistry Guided-Inquiry Experiments: Applying the Science Practices," in 2013 as part of the redesigned course. This article provides a discussion of the rationale for the existence of the manual as…

  7. Amphioxus and lamprey AP-2 genes: implications for neural crest evolution and migration patterns

    NASA Technical Reports Server (NTRS)

    Meulemans, Daniel; Bronner-Fraser, Marianne

    2002-01-01

    The neural crest is a uniquely vertebrate cell type present in the most basal vertebrates, but not in cephalochordates. We have studied differences in regulation of the neural crest marker AP-2 across two evolutionary transitions: invertebrate to vertebrate, and agnathan to gnathostome. Isolation and comparison of amphioxus, lamprey and axolotl AP-2 reveals its extensive expansion in the vertebrate dorsal neural tube and pharyngeal arches, implying co-option of AP-2 genes by neural crest cells early in vertebrate evolution. Expression in non-neural ectoderm is a conserved feature in amphioxus and vertebrates, suggesting an ancient role for AP-2 genes in this tissue. There is also common expression in subsets of ventrolateral neurons in the anterior neural tube, consistent with a primitive role in brain development. Comparison of AP-2 expression in axolotl and lamprey suggests an elaboration of cranial neural crest patterning in gnathostomes. However, migration of AP-2-expressing neural crest cells medial to the pharyngeal arch mesoderm appears to be a primitive feature retained in all vertebrates. Because AP-2 has essential roles in cranial neural crest differentiation and proliferation, the co-option of AP-2 by neural crest cells in the vertebrate lineage was a potentially crucial event in vertebrate evolution.

  8. 10 CFR Appendix C to Part 52 - Design Certification Rule for the AP600 Design

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Design Certification Rule for the AP600 Design C Appendix C to Part 52 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND... design, in accordance with 10 CFR part 52, subpart B. The applicant for certification of the AP600...

  9. Foundations for College and Beyond: Looking Back on AP Art History

    ERIC Educational Resources Information Center

    Schoenbohm, Laurel

    2013-01-01

    It was years after this author's AP Art History course in high school, and two years after college. She and some friends decided to fill a day during the Thanksgiving visits appreciating fine art. Prior to that AP course her senior year of high school, touring an art museum had seemed like the equivalent of going to the dentist. But after…

  10. AP3: Cooperative, decentralized anonymous communication Alan Mislove Gaurav Oberoi Ansley Post Charles Reis Peter Druschel

    E-print Network

    Wallach, Dan

    AP3: Cooperative, decentralized anonymous communication Alan Mislove Gaurav Oberoi Ansley Post, Seattle, WA, USA Abstract This paper describes a cooperative overlay network that provides anonymous communication services for participat- ing users. The Anonymizing Peer-to-Peer Proxy (AP3) sys- tem provides

  11. 10 CFR Appendix C to Part 52 - Design Certification Rule for the AP600 Design

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Design Certification Rule for the AP600 Design C Appendix C to Part 52 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Pt. 52, App. C Appendix C to Part 52—Design Certification Rule for the AP600 Design I. Introduction Appendix C...

  12. 10 CFR Appendix D to Part 52 - Design Certification Rule for the AP1000 Design

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Design Certification Rule for the AP1000 Design D Appendix D to Part 52 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Pt. 52, App. D Appendix D to Part 52—Design Certification Rule for the AP1000 Design I. Introduction Appendix...

  13. Social Effects of Hispanic Students Enrolled in an AP Class in Middle School

    ERIC Educational Resources Information Center

    Shiu, Alexandra; Kettler, Todd; Johnsen, Susan K.

    2009-01-01

    This article describes the effects of placing Spanish-speaking students in an Advanced Placement (AP) Spanish Language course in the 8th grade. Fifty-eight Hispanic students in the AP class and a similar comparison group answered survey questions on parental involvement, peers, sense of belonging at school, and academic aspirations. Data gathered…

  14. Release the Body, Release the Mind.

    ERIC Educational Resources Information Center

    Stoner, Martha Goff

    1998-01-01

    A college English teacher describes the anxiety and resentment of students during in-class writing assignments and the successful classroom use of meditation and body movement. Movement seemed to relax the students, change their attitudes, and release their creative impulses to write. Implications related to the body-mind connection are pondered.…

  15. Transcription factor AP-2 activates gene expression of HTLV-I.

    PubMed Central

    Muchardt, C; Seeler, J S; Nirula, A; Gong, S; Gaynor, R

    1992-01-01

    The HTLV-I LTR contains three conserved regulatory elements known as 21 base pair repeats which are required for stimulation of gene expression by the transactivator protein tax. Mutagenesis indicates that the 21 bp repeats can be subdivided into three motifs, A, B and C, each of which influences the level of tax activation. The A site in the 21 bp repeat has strong homology with previously described binding sites for the transcription factor AP-2. We demonstrated that AP-2 mRNA was present in T-lymphocytes and that cellular factors from both non-transformed and transformed T-lymphocytes specifically bound to the consensus motif for AP-2 in each 21 bp. To determine the role of AP-2 in the regulation of the HTLV-I LTR gene expression, we used an AP-2 cDNA in DNA binding and transient expression assays. Gel retardation and methylation interference studies revealed that bacterially produced AP-2 bound specifically and with high affinity to all three 21 bp repeats, and that it required the core sequence AGGC for specific binding. Binding of AP-2 prevented the subsequent binding of members of the CREB/ATF family to an adjacent regulatory motif in the 21 bp repeat. Transfection of an AP-2 expression construct into T-lymphocytes activated gene expression from the HTLV-I LTR. At least two 21 bp repeats were required for high levels of AP-2 activation and mutagenesis of the AP-2 consensus binding sequences in the 21 bp repeats eliminate this activation.(ABSTRACT TRUNCATED AT 250 WORDS) Images PMID:1628621

  16. 9. INTERIOR VIEW OF EYE PRESS AREA; TO LEFT IS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. INTERIOR VIEW OF EYE PRESS AREA; TO LEFT IS A TWO-BAY SLOTTED TYPE FURNACE, TO CENTER IS EYE PRESS, TO RIGHT IS CURCULAR SAW - Warwood Tool Company, Foot of Nineteenth Street, Wheeling, Ohio County, WV

  17. Structural and Biochemical Investigations of the Mechanism of Heme Capture by the Hemophore HasAp from Pseudomonas aeruginosa

    E-print Network

    Lagat, Grace Jepkorir

    2011-04-16

    HasAp is a hemophore secreted by Pseudomonas aeruginosa to the extracellular media under iron limited conditions to sequester heme from the host cell. The heme HasAp complex is captured by the specific cell surface receptor ...

  18. Large scientific releases

    SciTech Connect

    Pongratz, M.B.

    1981-01-01

    The motivation for active experiments in space is considered, taking into account the use of active techniques to obtain a better understanding of the natural space environment, the utilization of the advantages of space as a laboratory to study fundamental plasma physics, and the employment of active techniques to determine the magnitude, degree, and consequences of artificial modification of the space environment. It is pointed out that mass-injection experiments in space plasmas began about twenty years ago with the Project Firefly releases. Attention is given to mass-release techniques and diagnostics, operational aspects of mass release active experiments, the active observation of mass release experiments, active perturbation mass release experiments, simulating an artificial modification of the space environment, and active experiments to study fundamental plasma physics.

  19. Inhibition of K+ permeability diminishes alpha 2-adrenoceptor mediated effects on norepinephrine release

    SciTech Connect

    Zimanyi, I.; Folly, G.; Vizi, E.S.

    1988-05-01

    The effect of two different potassium channel blockers, 4-aminopyridine (4-AP) and quinine, on the alpha 2-adrenoceptor mediated modulation of norepinephrine (NE) release was investigated. Pairs of mouse vasa deferentia were loaded with /sup 3/H-norepinephrine (/sup 3/H-NE), superfused continuously, and stimulated electrically. 4-AP (5.3 x 10(-4) M), and quinine (10(-5) M) enhanced the stimulation-evoked release of tritium significantly. The electrically induced release of radioactivity was reduced by alpha 2-adrenoceptor agonists (1-NE and xylazine) and enhanced by the alpha 2-adrenoceptor antagonist yohimbine. Both effects were affected markedly by 4-AP or quinine: the depressant action of 1-NA and xylazine was partially antagonized and the facilitatory effect of yohimbine was completely abolished during the blockade of the potassium channels. It is suggested that the blockade of the potassium permeability counteracts negative feedback modulation; therefore, it seems likely that the stimulation of alpha 2-adrenoceptors leads to an enhanced potassium permeability and hyperpolarization of varicose axon terminals.

  20. Action Potential-Evoked Calcium Release Is Impaired in Single Skeletal Muscle Fibers from Heart Failure Patients

    PubMed Central

    DiFranco, Marino; Quiñonez, Marbella; Shieh, Perry; Fonarow, Gregg C.; Cruz, Daniel; Deng, Mario C.; Vergara, Julio L.; Middlekauff, Holly R.

    2014-01-01

    Background Exercise intolerance in chronic heart failure (HF) has been attributed to abnormalities of the skeletal muscles. Muscle function depends on intact excitation-contraction coupling (ECC), but ECC studies in HF models have been inconclusive, due to deficiencies in the animal models and tools used to measure calcium (Ca2+) release, mandating investigations in skeletal muscle from HF patients. The purpose of this study was to test the hypothesis that Ca2+ release is significantly impaired in the skeletal muscle of HF patients in whom exercise capacity is severely diminished compared to age-matched healthy volunteers. Methods and Findings Using state-of-the-art electrophysiological and optical techniques in single muscle fibers from biopsies of the locomotive vastus lateralis muscle, we measured the action potential (AP)-evoked Ca2+ release in 4 HF patients and 4 age-matched healthy controls. The mean peak Ca2+ release flux in fibers obtained from HF patients (10±1.2 µM/ms) was markedly (2.6-fold) and significantly (p<0.05) smaller than in fibers from healthy volunteers (28±3.3 µM/ms). This impairment in AP-evoked Ca2+ release was ubiquitous and was not explained by differences in the excitability mechanisms since single APs were indistinguishable between HF patients and healthy volunteers. Conclusions These findings prove the feasibility of performing electrophysiological experiments in single fibers from human skeletal muscle, and offer a new approach for investigations of myopathies due to HF and other diseases. Importantly, we have demonstrated that one step in the ECC process, AP-evoked Ca2+ release, is impaired in single muscle fibers in HF patients. PMID:25310188

  1. Predicting the performance of belt filter presses using the Crown Press for laboratory simulation

    SciTech Connect

    Graham, T.M.

    1999-07-26

    Belt filter presses (BFPs) are among the most commonly used devices to dewater wastewater sludge. The concept used by a BFP to achieve dewatered cake solids is relatively simple; however, replicating this performance in the laboratory in order to predict the performance of a BFP with reasonable reliability has proven to be a challenge. The Crown Press is one tool that has been shown to replicate the performance of anaerobically digested sludge on a BFP. This study used the Crown Press to replicate and predict the performance of waste activated sludge (WAS) from the Mauldin Road wastewater treatment plant on BFPs. Several operational variables, including belt speed, belt tension, polymer type, and polymer dose, were changed on the Crown Press to predict how the changes on the BFP would affect performance. Two polymers were chosen to be tested on the BFPs at Mauldin Road based on Crown Press predictions. The first polymer performed the same as the plant`s current polymer in the lab, and the second performed better (achieved higher final cake solids) than the current polymer. These predictions were borne out in the BFP tests, showing that the Crown Press predictions were accurate. The Crown Press predictions were also compared to the predictions made by the capillary suction time (CST) and specific resistance to filtration (SRF) tests. The Crown Press provided more information regarding the affect of polymer type and dose on cake solids than either CST or SRF. The Crown Press was shown to be a viable tool to assess potential changes in BFP performance with WAS when operational variables change.

  2. AP1000{sup R} licensing and deployment in the United States

    SciTech Connect

    Jordan, R. P.; Russ, P. A.; Filiak, P. P.; Castiglione, L. L.

    2012-07-01

    In recent years, both domestic and foreign utilities have turned to the standardized Westinghouse AP1000 plant design in satisfying their near - and long-term - sustainable energy needs. As direct support to these actions, licensing the AP1000 design has played a significant role by providing one of the fundamental bases in clearing regulatory hurdles leading to the start of new plant construction. Within the U.S. alone, Westinghouse AP1000 licensing activities have reached unprecedented milestones with the approvals of both AP1000 Design Certification and Southern Company's combined construction permit and operating license (COL) application directly supporting the construction of two new nuclear plants in Georgia. Further COL application approvals are immediately pending for an additional two AP1000 plants in South Carolina. And, across the U.S. nuclear industry spectrum, there are 10 other COL applications under regulatory review representing some 16 new plants at 10 sites. In total, these actions represent the first wave of new plant licensing under the regulatory approval process since 1978. Fundamental to the Nuclear Regulatory Commission's AP1000 Design Certification is the formal recognition of the AP1000 passive safety design through regulatory acceptance rulemaking. Through recognition and deployment of the AP1000 Design Certification, the utility licensee / operator of this reactor design are now offered an opportunity to use a simplified 'one-step' combined license process, thereby managing substantial back-end construction schedule risk from regulatory and intervention delays. Application of this regulatory philosophy represents both acceptance and encouragement of standardized reactor designs like the AP1000. With the recent AP1000 Design Certification and utility COL acceptances, the fundamental licensing processes of this philosophy have successfully proven the attainment of significant milestones with the next stage licensing actions directed towards deployment. AP1000 Design Certification and COL deployment, and management of the plant construction in accordance with the conditions within these approvals, remain as significant site and corporate responsibilities. These licensing-construction integrated activities must now focus on identifying and resolving 'as-built' departures from the standardized design as assessed against the certified AP1000 technical and licensing basis. Within this paper, significant aspects of the AP1000 U.S. licensing will be discussed, including identifying systems and processes used in ensuring compliance while deploying the standardized design. Critical licensing steps, licensing deployment actions as plant construction progresses and defining the road forward to a successful completion of licensing actions will be addressed. (authors)

  3. APS Alternative Fuel (Hydrogen) Pilot Plant - Monitoring System Report

    SciTech Connect

    James Francfort; Dimitri Hochard

    2005-07-01

    The U.S. Department of Energy’s (DOE’s) Advanced Vehicle Testing Activity (AVTA), along with Electric Transportation Applications and Arizona Pubic Service (APS), is monitoring the operations of the APS Alternative Fuel (Hydrogen) Pilot Plant to determine the costs to produce hydrogen fuels (including 100% hydrogen as well as hydrogen and compressed natural gas blends) for use by fleets and other operators of advanced-technology vehicles. The hydrogen fuel cost data will be used as benchmark data by technology modelers as well as research and development programs. The Pilot Plant can produce up to 18 kilograms (kg) of hydrogen per day by electrolysis. It can store up to 155 kg of hydrogen at various pressures up to 6,000 psi. The dispenser island can fuel vehicles with 100% hydrogen at 5,000 psi and with blends of hydrogen and compressed natural gas at 3,600 psi. The monitoring system was designed to track hydrogen delivery to each of the three storage areas and to monitor the use of electricity on all major equipment in the Pilot Plant, including the fuel dispenser island. In addition, water used for the electrolysis process is monitored to allow calculation of the total cost of plant operations and plant efficiencies. The monitoring system at the Pilot Plant will include about 100 sensors when complete (50 are installed to date), allowing for analysis of component, subsystems, and plant-level costs. The monitoring software is mostly off-the-shelve, with a custom interface. The majority of the sensors input to the Programmable Automation Controller as 4- to 20-mA analog signals. The plant can be monitored over of the Internet, but the control functions are restricted to the control room equipment. Using the APS general service plan E32 electric rate of 2.105 cents per kWh, during a recent eight-month period when 1,200 kg of hydrogen was produced and the plant capacity factor was 26%, the electricity cost to produce one kg of hydrogen was $3.43. However, the plant capacity factor has been increasing, with a recent one-month high of 49%. If a plant capacity factor of 70% can be achieved with the present equipment, the cost of electricity would drop to $2.39 per kg of hydrogen. In this report, the power conversion (76.7%), cell stack (53.1%), and reverse osmosis system (7.14%) efficiencies are also calculated, as is the water cost per kg of hydrogen produced ($0.10 per kg). The monitoring system has identified several areas having the potential to lower costs, including using an reverse osmosis system with a higher efficiency, improving the electrolysis power conversion efficiency, and using air cooling to replace some or all chiller cooling. These activities are managed by the Idaho National Laboratory for the AVTA, which is part of DOE’s FreedomCAR and Vehicle Technologies Program.

  4. Enhancing and Archiving the APS Catalog of the POSS I

    NASA Technical Reports Server (NTRS)

    Humphreys, Roberta M.

    2003-01-01

    We have worked on two different projects: 1) Archiving the APS Catalog of the POSS I for distribution to NASA's NED at IPAC, SIMBAD in France, and individual astronomers and 2) The automated morphological classification of galaxies. We have completed archiving the Catalog into easily readable binary files. The database together with the software to read it has been distributed on DVD's to the national and international data centers and to individual astronomers. The archived Catalog contains more than 89 million objects in 632 fields in the first epoch Palomar Observatory Sky Survey. Additional image parameters not available in the original on-line version are also included in the archived version. The archived Catalog is also available and can be queried at the APS web site (URL: http://aps.umn.edu) which has been improved with a much faster and more efficient querying system. The Catalog can be downloaded as binary datafiles with the source code for reading it. It is also being integrated into the SkyQuery system which includes the Sloan Digital Sky Survey, 2MASS, and the FIRST radio sky survey. We experimented with different classification algorithms to automate the morphological classification of galaxies. This is an especially difficult problem because there are not only a large number of attributes or parameters and measurement uncertainties, but also the added complication of human disagreement about the adopted types. To solve this problem we used 837 galaxy images from nine POSS I fields at the North Galactic Pole classified by two independent astronomers for which they agree on the morphological types. The initial goal was to separate the galaxies into the three broad classes relevant to issues of large scale structure and galaxy formation and evolution: early (ellipticals and lenticulars), spirals, and late (irregulars) with an accuracy or success rate that rivals the best astronomer classifiers. We also needed to identify a set of parameters derived from the digitized images that separate the galaxies by type. The human eye can easily recognize complicated patterns in images such as spiral arms which can be spotty, blotchy affairs that are difficult for automated techniques. A galaxy image can potentially be described by hundreds of parameters, all of which may have some relation to the morphological type. In the set of initial experiments we used 624 such parameters, in two colors, blue and red. These parameters include the surface brightness and color measured at different radii, ratios of these parameters at different radii, concentration indices, Fourier transforms and wavelet decomposition coefficients. We experimented with three different classes of classification algorithms; decision trees, k-nearest neighbors, and support vector machines (SVM). A range of experiments were conducted and we eventually narrowed the parameters to 23 selected parameters. SVM consistently outperformed the other algorithms with both sets of features. By combining the results from the different algorithms in a weighted scheme we achieved an overall classification success of 86%.

  5. Preface: 18th Aps-Sccm and 24th Airapt

    NASA Astrophysics Data System (ADS)

    Collins, Gilbert; Moore, David S.; Yoo, Choong-Shik; Buttler, William; Furlanetto, Michael; Evans, William

    2014-05-01

    The 18th Biennial International Conference of the APS Topical Group on Shock Compression of Condensed Matter in conjunction with the 24th Biennial International Conference of the International Association for the Advancement of High Pressure Science & Technology (AIRAPT) was held at the Westin Hotel in Seattle, Washington from 7-12 July, 2013. This is only the second time that these two organizations have held a Joint Conference — the first was 20 years previous (1993) in Colorado Springs, Colorado. Seattle was chosen for this joint conference because of its central location for the world-wide attendees as well as its metropolitan vibrancy. The scientific program consisted of 858 scheduled presentations organized into 23 topical areas and included contributed (537), invited (95), and plenary (6) lectures, as well as two poster sessions with 110 posters each. The scientific focus of the Joint Conference was on fundamental and applied research topics related to the static or dynamic compression of condensed matter. This multidisciplinary field of research encompasses areas of physics, chemistry, materials science, mechanics, geophysics and planetary physics, and applied mathematics. Experimental, computational and theoretical studies all play important roles. The organizers endeavored to intertwine static and dynamic experimental alongside computational and theoretical studies of similar materials in the organization of the sessions. This goal was aided by the addition of three special focus sessions on deep carbon budget, high energy density materials, and dynamic response of materials. 722 scientists and engineers from 25 countries registered at the conference, including 132 students from 12 countries. The attendee countries represented included: Argentina (2), Australia (2), Brazil (3), Canada (25), China (22), Czech Republic (2), France (35), Germany (19), India (6), Israel (21), Italy (10), Japan (49), Netherlands (1), Poland (1), Portugal (2), Russia (26), Singapore (1), Slovakia (1), South Korea (5), Spain (7), Sweden (4), Switzerland (1), United Kingdom (69), United States of America (402). 79 of the students were supported by travel awards, funded in part by the APS Topical Group, the AIRAPT, and other sources. New for this conference was an expanded Student Program, including an all-day Student, Post-Doc, and Early Career Symposium held on Sunday 7 July . During the Conference, Gennady Kanel of the Institute for High Temperatures, Russian Academy of Sciences, was presented the 2013 George E Duval Shock Compression Science Award, and gave a plenary lecture ''Unusual behavior of usual materials in shock waves.'' Similarly, Karl Syassen of the Max Planck Institute Stuttgart received the 2013 Percy Bridgman Award at the conference, and presented a plenary lecture ''Stressed solids probed by diffraction and spectroscopy.'' In addition, there were two young investigator awards presented. First was the AIRAPT Jamieson Award, presented to Duck Young Kim of the Geophysical Laboratory, Carnegie Institution of Washington, DC. The other was a new APS SCCM Topical Group Student Award, presented to Rick Kraus of Harvard University. The two awardees shared a plenary talk slot on 8 July, with Duck Young Kim presenting ''Novel materials prediction and experimental synthesis under pressure'' and Rick Kraus ''Thermodynamic paths in planetary collisions: Shock vaporization of SiO2, MgO, and Fe.'' Details of the committees are available in the PDF

  6. Lesquerella Press Cake as an Organic Fertilizer for Greenhouse Tomatoes

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Lesquerella press cake is a co-product generated during the processing of the new oilseed crop lesquerella [Lesquerella fendleri (A. Gray) S. Wats.]. As with other new crops, developing commercial uses for the press cake would increase the profitability of growing lesquerella. The press cake conta...

  7. The Press, Japanese Americans, and the Concentration Camps.

    ERIC Educational Resources Information Center

    Okihiro, Gary Y.; Sly, Julie

    1983-01-01

    A study of the wartime press suggests that the plan to incarcerate Japanese Americans (under Executive Order 9066) was government-initiated, that the public and the press initially disapproved of such treatment, and that events emanating from the government influenced shifts in press and public opinion that allowed implementation of the plan.…

  8. Graphic Arts: The Press and Finishing Processes. Third Edition.

    ERIC Educational Resources Information Center

    Crummett, Dan

    This document contains teacher and student materials for a course in graphic arts concentrating on printing presses and the finishing process for publications. Seven units of instruction cover the following topics: (1) offset press systems; (2) offset inks and dampening chemistry; (3) offset press operating procedures; (4) preventive maintenance…

  9. Lesquerella Press Cake as an Organic Fertilizer for Greenhouse Tomatoes

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Lesquerella press cake is a co-product generated during the processing of the new oilseed crop lesquerella [Lesquerella fendleri (A. Gray) S. Wats.]. Developing commercial uses for the press cake would increase the profitability of growing lesquerella. The press cake contains levels of nutrients w...

  10. Consumer Satisfaction with Durable-Press Shirts. 

    E-print Network

    Stover, Mary Sue

    1972-01-01

    evaluated for fabric smoothness by a trained panel of three members using three-dimensional plastic repli- cas. Durable-press ratings of the standardized references ranged from 1 (severe wrinkles) to 5 (wrinkle-free). The panel was more critical in its... shirts received a 5 rating (smooth appearance, no wrinkles). . "'hndurable-press shirt-not evaluated by panel. the wear study as indicated by low ratings on a11 satisfaction factors evaluated. The level of wrinkle-free performance ac- ceptable...

  11. Measure Your Sew - How: Pressing Points. 

    E-print Network

    Odle-Kemp, Marlene

    1979-01-01

    on the fabric. When dampened, it provides steam when tailoring or applying fusibles. Choose a weight compatible w,ith the fabric. When pressing pile fabrics, use a scrap of self-fabric, placing nap to nap. A dampened terry washcloth makes a good press cloth... sturdy surface such as a table before pounding. Needleboard. The needleboard is a bed of steel wires mounted on a flat piece of heavy canvas that is placed between the ironing board and piled fabric to prevent flattening the nap (see Figure 12). As a...

  12. Development of Press-Coated, Floating-Pulsatile Drug Delivery of Lisinopril

    PubMed Central

    Jagdale, Swati C.; Suryawanshi, Vishnu M.; Pandya, Sudhir V.; Kuchekar, Bhanudas S.; Chabukswar, Aniruddha R.

    2014-01-01

    Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor, primarily used for the treatment of hypertension, congestive heart failure, and heart attack. It belongs to BCS class III having a half-life of 12 hrs and 25% bioavailability. The purpose of the present work was to develop a press-coated, floating-pulsatile drug delivery system. The core tablet was formulated using the super-disintegrants crosprovidone and croscarmellose sodium. A press-coated tablet (barrier layer) contained the polymer carrageenan, xanthan gum, HPMC K4M, and HPMC K15M. The buoyant layer was optimized with HPMC K100M, sodium bicarbonate, and citric acid. The tablets were evaluated for physical characteristics, floating lag time, swelling index, FTIR, DSC, and in vitro and in vivo behavior. The 5% superdisintgrant showed good results. The FTIR and DSC study predicted no chemical interactions between the drug and excipients. The formulation containing xanthan gum showed drug retaining abilities, but failed to float. The tablet containing HPMC K15M showed a high swelling index. The lag time for the tablet coated with 200 mg carrageenan was 3±0.1 hrs with 99.99±1.5% drug release; with 140 mg HPMC K4M, the lag time was 3±0.1 hrs with 99.71±1.2% drug release; and with 120 mg HPMC K15M, the lag time was 3±0.2 hrs with 99.98±1.7% drug release. The release mechanism of the tablet followed the Korsmeyer-Peppas equation and a first-order release pattern. Floating and lag time behavior have shown good in vitro and in vivo correlations. PMID:24959410

  13. Development of press-coated, floating-pulsatile drug delivery of lisinopril.

    PubMed

    Jagdale, Swati C; Suryawanshi, Vishnu M; Pandya, Sudhir V; Kuchekar, Bhanudas S; Chabukswar, Aniruddha R

    2014-06-01

    Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor, primarily used for the treatment of hypertension, congestive heart failure, and heart attack. It belongs to BCS class III having a half-life of 12 hrs and 25% bioavailability. The purpose of the present work was to develop a press-coated, floating-pulsatile drug delivery system. The core tablet was formulated using the super-disintegrants crosprovidone and croscarmellose sodium. A press-coated tablet (barrier layer) contained the polymer carrageenan, xanthan gum, HPMC K4M, and HPMC K15M. The buoyant layer was optimized with HPMC K100M, sodium bicarbonate, and citric acid. The tablets were evaluated for physical characteristics, floating lag time, swelling index, FTIR, DSC, and in vitro and in vivo behavior. The 5% superdisintgrant showed good results. The FTIR and DSC study predicted no chemical interactions between the drug and excipients. The formulation containing xanthan gum showed drug retaining abilities, but failed to float. The tablet containing HPMC K15M showed a high swelling index. The lag time for the tablet coated with 200 mg carrageenan was 3±0.1 hrs with 99.99±1.5% drug release; with 140 mg HPMC K4M, the lag time was 3±0.1 hrs with 99.71±1.2% drug release; and with 120 mg HPMC K15M, the lag time was 3±0.2 hrs with 99.98±1.7% drug release. The release mechanism of the tablet followed the Korsmeyer-Peppas equation and a first-order release pattern. Floating and lag time behavior have shown good in vitro and in vivo correlations. PMID:24959410

  14. Advanced Placement Exams (AP) and International Baccalaureate Higher Level Exams (IBH) 2015-2016 (General Education Requirements)

    E-print Network

    California at Santa Cruz, University of

    and Composition and Literature and Composition exams 4,5 8 C1 Literature & Composition 3 8 4,5 8 C1 AP Page 3 AP Exams Subject Score Qtr Units Gen Ed UCSC Course Equivalency Notes: AP Spanish Literature Applied Mathematics and Statistics 3 Mathematics 3. Allows enrollment in Math 11A or 19A. Maximum of 8

  15. Wide dynamic range APS star tracker Orly Yadid-Pecht, Christopher Clark, Bedabrata Pain, Craig Staller, and Eric Fossum

    E-print Network

    Fossum, Eric R.

    Wide dynamic range APS star tracker Orly Yadid-Pecht, Christopher Clark, Bedabrata Pain, Craig) star tracker are reported. APS technology has been thought of being most appropriate for guidance and navigation. However, making APS useful for future star tracker missions means a few challenges have

  16. Advanced Placement Chemistry: Project Advance and the Advanced Placement Program: A Comparison of Students' Performance on the AP Chemistry Examination.

    ERIC Educational Resources Information Center

    Mercurio, Joseph; And Others

    1984-01-01

    Compared performance of Syracuse University Project Advance (PA) chemistry students (N=35) with advanced placement (AP) candidates on the AP chemistry examination. PA students scored slightly above the national average on the examination, and students who performed well (B or better) in AP chemistry also did well on the examination. (JN)

  17. Last Name (print): ___________________________ First Name __________________ ID________________ Request to Allow WSU Course Credit and to Omit AP Credit Already Awarded

    E-print Network

    ________________ Request to Allow WSU Course Credit ­ and to Omit AP Credit Already Awarded From Rule 15: Credit credit. Prompted by the request, the AP, IB, or CLEP credit is removed from the overall credits awarded and grade point average; the AP, IB, or CLEP credit cannot be reconsidered for credit for the same course

  18. Last Name (print): ___________________________ First Name __________________ ID________________ Request to Allow WSU Course Credit and to Omit AP Credit Already Awarded

    E-print Network

    ________________ Request to Allow WSU Course Credit ­ and to Omit AP Credit Already Awarded From Rule 15: Credit credit. Prompted by the request, the AP, IB, CIE or CLEP credit is removed from the overall credits and grade point average; the AP, IB, CIE or CLEP credit cannot be reconsidered for credit for the same

  19. The Development of Multiple-Choice Items Consistent with the AP Chemistry Curriculum Framework to More Accurately Assess Deeper Understanding

    ERIC Educational Resources Information Center

    Domyancich, John M.

    2014-01-01

    Multiple-choice questions are an important part of large-scale summative assessments, such as the advanced placement (AP) chemistry exam. However, past AP chemistry exam items often lacked the ability to test conceptual understanding and higher-order cognitive skills. The redesigned AP chemistry exam shows a distinctive shift in item types toward…

  20. Mechanisms of NOS1AP action on NMDA receptor-nNOS signaling

    PubMed Central

    Courtney, Michael J.; Li, Li-Li; Lai, Yvonne Y.

    2014-01-01

    NMDA receptors (NMDAR) are glutamate-gated calcium channels that play pivotal roles in fundamental aspects of neuronal function. Dysregulated receptor function contributes to many disorders. Recruitment by NMDARs of calcium-dependent enzyme nNOS via PSD95 is seen as a key contributor to neuronal dysfunction. nNOS adaptor protein (NOS1AP), originally described as a competitor of PSD95:nNOS interaction, is regarded an inhibitor of NMDAR-driven nNOS function. In conditions of NMDAR hyperactivity such as excitotoxicity, one expects NOS1AP to be neuroprotective. Conditions of NMDAR hypoactivity, as thought to occur in schizophrenia, might be exacerbated by NOS1AP. Indeed GWAS have implicated NOS1AP and nNOS in schizophrenia. Several studies now indicate NOS1AP can mediate rather than inhibit NMDAR/nNOS-dependent responses, including excitotoxic signaling. Yet the concept of NOS1AP as an inhibitor of nNOS predominates in studies of human disease genetics. Here we review the experimental evidence to evaluate this apparent controversy, consider whether the known functions of NOS1AP might defend neurons against NMDAR dysregulation and highlight specific areas for future investigation to shed light on the functions of this adaptor protein. PMID:25221472