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1

Effective Press Releases  

Microsoft Academic Search

Stresses the importance of the effective management of the release of information to the media and the development of media relations. Considers reasons for good and bad press. Advises on the presentation of press releases, the elements of their content and their structure. Looks at how additional information should be supplied, and how photographs can be used to illustrate a

Linda S. Ashcroft

1994-01-01

2

7 CFR 550.29 - Press releases.  

Code of Federal Regulations, 2010 CFR

... 6 2010-01-01 2010-01-01 false Press releases. 550.29 Section 550.29 Agriculture...Agreements Program Management § 550.29 Press releases. Press releases or other forms of public notification will...

2010-01-01

3

7 CFR 550.29 - Press releases.  

Code of Federal Regulations, 2010 CFR

... 6 2009-01-01 2009-01-01 false Press releases. 550.29 Section 550.29 Agriculture...Agreements Program Management § 550.29 Press releases. Press releases or other forms of public notification will...

2009-01-01

4

Self-reference in press releases  

Microsoft Academic Search

This article looks at press releases. Drawing from corpus-based evidence on reflexive person, time and place deixis, I shall argue that self-reference in press releases is part of a point of view operation with the writers of press releases switching out of their own perspective towards that of the journalists, who will have to copy the press releases in their

Geert Jacobs

1999-01-01

5

Are Investors Influenced By How Earnings Press Releases Are Written?  

Microsoft Academic Search

This two-part study begins with a rhetorical analysis of the genre of earnings press releases. Then, a quantitative analysis uses capital markets data to assess the investor impact of tone and other stylistic attributes. The genre analysis explores the regulatory context, structural attributes, and dual informational-promotional role of earnings press releases, using individual releases as illustrations. The quantitative analysis explores

Elaine Henry

2008-01-01

6

Retailers' press release activity: market signals for stakeholder engagement?  

Microsoft Academic Search

Purpose To increase understanding of the role, content and effectiveness of press releases. Design\\/methodology\\/approach Qualitative and quantitative analyses of UK supermarkets' press releases in 2001\\/2002, a medium previously little researched in marketing, are undertaken. Findings Supermarkets seek stakeholder engagement on diverse issues with different mixes of groups. Treating releases as market signals demonstrates the important role of

Paul Whysall

2005-01-01

7

Bar press and bar release as avoidance responses1  

PubMed Central

Two experiments were performed in which rats had to avoid shock by both pressing and releasing a bar within specified intervals. When the release-shock interval was held constant and the press-shock interval was increased, response rate decreased and bar holding increased. When the press-shock interval was held constant and the release-shock interval was increased, both response rate and bar holding decreased.

Meltzer, Donald; Tiller, James E.

1979-01-01

8

Quality of Pharmaceutical Industry Press Releases Based on Original Research  

PubMed Central

Background Press releases are a popular vehicle to disseminate health information to the lay media. While the quality of press releases issued by scientific conferences and medical journals has been questioned, no efforts to assess pharmaceutical industry press releases have been made. Therefore, we sought to systematically examine pharmaceutical company press releases about original research for measures of quality. Methodolgy/Principal Findings Press releases issued by the ten top selling, international pharmaceutical companies in the year 2005 were selected for evaluation. A total of 1028 electronic press releases were issued and 235 were based on original research. More than half (59%) reported results presented at a scientific meeting. Twenty-one percent of releases were not explicit about the source of original data. While harms or adverse events were commonly cited (76%), study limitations were rarely noted (6%). Almost one-third (29%) of releases did not quantify study results. Studies presented in abstract form were subsequently published within at least 20 months in 53% of cases. Conclusions Pharmaceutical company press releases frequently report basic study details. However, readers should be cautioned by the preliminary nature of the data and lack of identified limitations. Methods to improve the reporting and interpretation of drug company press releases are desirable to prevent misleading media coverage.

Kuriya, Bindee; Schneid, Elana C.; Bell, Chaim M.

2008-01-01

9

Beyond preformulation: an ethnographic perspective on press releases  

Microsoft Academic Search

It has been shown that press releases are heavily preformulated, that is to say, they exhibit a number of metapragmatic features that make it easy for journalists to copy them in their own news reporting. The present article sets out to further explore this notion of preformulation by presenting ethnography-based work on how press releases are being written at the

Kim Sleurs; Geert Jacobs

2005-01-01

10

Formaldehyde release from pressed-wood products  

SciTech Connect

A formaldehyde surface emission monitor (FSEM) was developed for quantitative non-destructive measurement of CH/sub 2/O emission from pressed-wood products. A detection limit of 0.03 mg CH/sub 2/O/m/sup 2/h is achieved with a 0.2 m diameter monitor using a 3 h collection period. Investigation of the effects of environmental and product use parameters on pressed-wood emissions was performed to support modeling of the CH/sub 2/O concentration in indoor domestic environments. The model will ultimately include parameters for the generic effects of temperature, water and CH/sub 2/O vapor concentration, product age, CH/sub 2/O sinks, and common permeation barriers on the CH/sub 2/O emission rate of pressed-wood products. (PSB)

Matthews, T.G.; Hawthorne, A.R.; Daffron, C.R.; Reed, T.J.; Corey, M.D.

1983-01-01

11

Hypoxia Press Release and Map - August 1, 2005  

NSDL National Science Digital Library

This EPA press release documents the findings of a 2005 mapping project in the Gulf of Mexico low-oxygen waters. The article notes the extent of the "dead zone" and notes the possible effects of Hurricane Dennis on the hypoxic zone. It also reports a smaller than expected nitrate content in the dead zone, which was attributed to the below average precipitation in the Mississippi River Basin. The press release also features a color map of the dead zone's extent.

Office, Epa- G.

12

How Promotional Language in Press Releases Is Dealt With by Journalists: Genre Mixing or Genre Conflict?  

Microsoft Academic Search

This study investigates how promotional language in corporate press releases is dealt with when the release is reused in different journalistic genres. Using a new coding system, it analyzes 89 press releases and their journalistic transformations. Promotional language is shown to be a regular feature of corporate press releases, especially those presenting new products or services. The first press release

Henk Pander Maat

2007-01-01

13

The CAPRI Project: Coordinates for Astronomical Press Release Images  

NASA Astrophysics Data System (ADS)

The beauty and splendor of astronomical press release images has made an enormously positive impact with the media and public alike. As a leading provider of astronomical imagery and a major contributor of Hubble Space Telescope press release images, the outreach division of Space Telescope Science Institute (STScI) recognizes the importance of making press release images compliant with virtual observatory standards for inclusion in databases and repositories. Our goal is to make outreach images accessible by virtual observatory applications by calculating World Coordinate System (WCS) data for these images. We provide updated and improved software that allows observatories to easily and accurately transform coordinates on their astronomical press release images, using reference FITS files. The resultant metadata conforms to the Simple Image Access (SIA) protocol established by the International Virtual Observatory Alliance and has been used by popular end users such as Google Sky and World Wide Telescope. Several hundred images from the STScI Office of Public Outreach NewsCenter database have been processed, and their coordinates and other relevant metadata are accessible through an SIA-compliant web service.

Frattare, Lisa M.; Ferguson, B. A.; Summers, F.; Levay, Z. G.

2009-01-01

14

An Exploratory Study of Credibility Issues in Astronomy Press Releases  

Microsoft Academic Search

Summary Current developments in the media marketplace and an increased need for visibility to secure funding are leading inevitably to faster, simpler and more aggressive science communication. This article presents the results of an exploratory study of potential credibility problems in astronomy press releases, their causes, consequences and possible remedies. The study consisted of eleven open-ended interviews with journalists, scientists

Lars Lindberg Christensen; Lars Holm Nielsen; Nanna Torpe Jrgensen; Kim Jantzen

15

Modulation of Venlafaxine Hydrochloride Release from Press Coated Matrix Tablet  

PubMed Central

The aim of present study was to prepare novel modified release press coated tablets of venlafaxine hydrochloride. Hydroxypropylmethylcellulose K4M and hydroxypropylmethylcellulose K100M were used as release modifier in core and coat, respectively. A 32 full factorial design was adopted in the optimization study. The drug to polymer ratio in core and coat were chosen as independent variables. The drug release in the first hour and drug release rate between 1 and 12 h were chosen as dependent variables. The tablets were characterized for dimension analysis, crushing strength, friability and in vitro drug release. A check point batch, containing 1:2.6 and 1:5.4 drug to polymer in core and coat respectively, was prepared. The tablets of check point batch were subjected to in vitro drug release in dissolution media with pH 5, 7.2 and distilled water. The kinetics of drug release was best explained by Korsmeyer and Peppas model (anomalous non-Fickian diffusion). The systematic formulation approach enabled us to develop modified release venlafaxine hydrochloride tablets.

Gohel, M. C.; Soni, C. D.; Nagori, S. A.; Sarvaiya, K. G.

2008-01-01

16

JPL Press Release: NASA Astronomers Find Solar System Around Star  

NSDL National Science Digital Library

National Aeronautics and Space Administration astronomers, using the Keck II telescope in Hawaii, along with a team of scientists from the Harvard-Smithsonian Center for Astrophysics and the University of Florida, Gainesville, using the Cerro Tololo Observatory in Chile, "have discovered what appears to be the clearest evidence yet of a budding solar system around a nearby star." HR 4796, about 220 light years from Earth, "shows a swirling disk of dust around the star" that portends the building of a star system. The Jet Propulsion Laboratory press release explains the meaning of the findings.

1998-01-01

17

Processing map for controlling microstructure in hot working of hot isostatically pressed powder metallurgy NIMONIC AP1 superalloy  

Microsoft Academic Search

The hot deformation behavior of hot isostatically pressed (HIP) NIMONIC AP-1 superalloy is characterized using processing\\u000a maps in the temperature range 950 ?C to 1200 ?C and strain rate range 0.001 to 100 s1. The dynamic materials model has been used for developing the pro-cessing maps which show the variation of the efficiency\\u000a of power dissipation given by [2m\\/ (m

M. C. Somani; E. S. Bhagiradha Rao; N. C. Birla; M. L. Bhatia; Vakil Singh; Y. V. R. K. Prasad

1992-01-01

18

Influence of medical journal press releases on the quality of associated newspaper coverage: retrospective cohort study  

PubMed Central

Objective To determine whether the quality of press releases issued by medical journals can influence the quality of associated newspaper stories. Design Retrospective cohort study of medical journal press releases and associated news stories. Setting We reviewed consecutive issues (going backwards from January 2009) of five major medical journals (Annals of Internal Medicine, BMJ, Journal of the National Cancer Institute, JAMA, and New England Journal of Medicine) to identify the first 100 original research articles with quantifiable outcomes and that had generated any newspaper coverage (unique stories ?100 words long). We identified 759 associated newspaper stories using Lexis Nexis and Factiva searches, and 68 journal press releases using Eurekalert and journal website searches. Two independent research assistants assessed the quality of journal articles, press releases, and a stratified random sample of associated newspaper stories (n=343) by using a structured coding scheme for the presence of specific quality measures: basic study facts, quantification of the main result, harms, and limitations. Main outcome Proportion of newspaper stories with specific quality measures (adjusted for whether the quality measure was present in the journal articles abstract or editor note). Results We recorded a median of three newspaper stories per journal article (range 1-72). Of 343 stories analysed, 71% reported on articles for which medical journals had issued press releases. 9% of stories quantified the main result with absolute risks when this information was not in the press release, 53% did so when it was in the press release (relative risk 6.0, 95% confidence interval 2.3 to 15.4), and 20% when no press release was issued (2.2, 0.83 to 6.1). 133 (39%) stories reported on research describing beneficial interventions. 24% mentioned harms (or specifically declared no harms) when harms were not mentioned in the press release, 68% when mentioned in the press release (2.8, 1.1 to 7.4), and 36% when no press release was issued (1.5, 0.49 to 4.4). 256 (75%) stories reported on research with important limitations. 16% reported any limitations when limitations were not mentioned in the press release, 48% when mentioned in the press release (3.0, 1.5 to 6.2), and 21% if no press release was issued (1.3, 0.50 to 3.6). Conclusion High quality press releases issued by medical journals seem to make the quality of associated newspaper stories better, whereas low quality press releases might make them worse.

2012-01-01

19

Factors Underlying Organizations' Successful Press Release Publication in Newspapers: Additional PR Elements for the Evolving Press Agentry and Public Information Models  

Microsoft Academic Search

This study tests 71 PR elements and tools regarding publishing success of 373 press releases in light of PR's two major, unidirectional models: press agentry and public information. Thirteen PR agencies and 12 subject areas were analyzed. A formula was developed to pinpoint the successful PR elements in 575 published news items emanating from these press releases. The main elements

Michal Seletzky; Sam Lehman-Wilzig

2010-01-01

20

Framing the Candidates in Presidential Primaries: Issues and Images in Press Releases and News Coverage  

Microsoft Academic Search

Media coverage of presidential primaries is crucial to voters, and candidates often complain that news coverage fails to present their positions. This study used computerized content analysis to examine how the 1996 GOP presidential candidates framed themselves in press releases and how elite newspapers covered them. The analysis reveals that (1) candidate images were distinct in press releases and news

M. Mark Miller; Julie L. Andsager; Bonnie P. Riechert

1998-01-01

21

Framing the Candidates in Presidential Primaries: Issues and Images in Press Releases and News Coverage.  

ERIC Educational Resources Information Center

Contributes to research on political communication by examining how 1996 GOP presidential candidates framed themselves in press releases and how elite newspapers covered them. Shows that candidate images were distinct in press releases and news stories; candidate positions were represented differently in both; and candidates were differentially

Miller, M. Mark; Andsager, Julie L.; Riechert, Bonnie P.

1998-01-01

22

Misrepresentation of Randomized Controlled Trials in Press Releases and News Coverage: A Cohort Study  

PubMed Central

Background Previous studies indicate that in published reports, trial results can be distorted by the use of spin (specific reporting strategies, intentional or unintentional, emphasizing the beneficial effect of the experimental treatment). We aimed to (1) evaluate the presence of spin in press releases and associated media coverage; and (2) evaluate whether findings of randomized controlled trials (RCTs) based on press releases and media coverage are misinterpreted. Methods and Findings We systematically searched for all press releases indexed in the EurekAlert! database between December 2009 and March 2010. Of the 498 press releases retrieved and screened, we included press releases for all two-arm, parallel-group RCTs (n?=?70). We obtained a copy of the scientific article to which the press release related and we systematically searched for related news items using Lexis Nexis. Spin, defined as specific reporting strategies (intentional or unintentional) emphasizing the beneficial effect of the experimental treatment, was identified in 28 (40%) scientific article abstract conclusions and in 33 (47%) press releases. From bivariate and multivariable analysis assessing the journal type, funding source, sample size, type of treatment (drug or other), results of the primary outcomes (all nonstatistically significant versus other), author of the press release, and the presence of spin in the abstract conclusion, the only factor associated, with spin in the press release was spin in the article abstract conclusions (relative risk [RR] 5.6, [95% CI 2.811.1], p<0.001). Findings of RCTs based on press releases were overestimated for 19 (27%) reports. News items were identified for 41 RCTs; 21 (51%) were reported with spin, mainly the same type of spin as those identified in the press release and article abstract conclusion. Findings of RCTs based on the news item was overestimated for ten (24%) reports. Conclusion Spin was identified in about half of press releases and media coverage. In multivariable analysis, the main factor associated with spin in press releases was the presence of spin in the article abstract conclusion.

Yavchitz, Amelie; Boutron, Isabelle; Bafeta, Aida; Marroun, Ibrahim; Charles, Pierre; Mantz, Jean; Ravaud, Philippe

2012-01-01

23

Voluntary disclosure of accruals in earnings press releases and the pricing of accruals  

Microsoft Academic Search

This study investigates firms decisions to disclose accruals information in earnings press releases versus to provide it\\u000a only in 10-Q filings and the impact of this disclosure on the pricing of accruals. I find that firms disclose accruals in\\u000a their press releases when earnings alone are a weak indication of cash flow performance and that following these disclosures\\u000a the accruals

Shai Levi

2008-01-01

24

Widespread Dysregulation of Peptide Hormone Release in Mice Lacking Adaptor Protein AP-3  

PubMed Central

The regulated secretion of peptide hormones, neural peptides and many growth factors depends on their sorting into large dense core vesicles (LDCVs) capable of regulated exocytosis. LDCVs form at the trans-Golgi network, but the mechanisms that sort proteins to this regulated secretory pathway and the cytosolic machinery that produces LDCVs remain poorly understood. Recently, we used an RNAi screen to identify a role for heterotetrameric adaptor protein AP-3 in regulated secretion and in particular, LDCV formation. Indeed, mocha mice lacking AP-3 have a severe neurological and behavioral phenotype, but this has been attributed to a role for AP-3 in the endolysosomal rather than biosynthetic pathway. We therefore used mocha mice to determine whether loss of AP-3 also dysregulates peptide release in vivo. We find that adrenal chromaffin cells from mocha animals show increased constitutive exocytosis of both soluble cargo and LDCV membrane proteins, reducing the response to stimulation. We also observe increased basal release of both insulin and glucagon from pancreatic islet cells of mocha mice, suggesting a global disturbance in the release of peptide hormones. AP-3 exists as both ubiquitous and neuronal isoforms, but the analysis of mice lacking each of these isoforms individually and together shows that loss of both is required to reproduce the effect of the mocha mutation on the regulated pathway. In addition, we show that loss of the related adaptor protein AP-1 has a similar effect on regulated secretion but exacerbates the effect of AP-3 RNAi, suggesting distinct roles for the two adaptors in the regulated secretory pathway.

Sirkis, Daniel W.; Edwards, Robert H.; Asensio, Cedric S.

2013-01-01

25

Loss of AP3 function affects spontaneous and evoked release at hippocampal mossy fiber synapses  

Microsoft Academic Search

Synaptic vesicle (SV) exocytosis mediating neurotransmitter release occurs spontaneously at low intraterminal calcium concentrations and is stimulated by a rise in intracellular calcium. Exocytosis is compensated for by the reformation of vesicles at plasma membrane and endosomes. Although the adaptor complex AP-3 was proposed to be involved in the formation of SVs from endosomes, whether its function has an indirect

Anita Scheuber; Rachel Rudge; Lydia Danglot; Graca Raposo; Thomas Binz; J.-C. Poncer; Thierry Galli

2006-01-01

26

To Bind or Not to Bind? Different Temporal Binding Effects from Voluntary Pressing and Releasing Actions  

PubMed Central

Binding effect refers to the perceptual attraction between an action and an outcome leading to a subjective compression of time. Most studies investigating binding effects exclusively employ the pressing action without exploring other types of actions. The present study addresses this issue by introducing another action, releasing action or the voluntary lifting of the finger/wrist, to investigate the differences between voluntary pressing and releasing actions. Results reveal that releasing actions led to robust yet short-lived temporal binding effects, whereas pressing condition had steady temporal binding effects up to super-seconds. The two actions also differ in sensitivity to changes in temporal contiguity and contingency, which could be attributed to the difference in awareness of action. Extending upon current models of willed action, our results provide insights from a temporal point of view and support the concept of a dual system consisting of predictive motor control and top-down mechanisms.

Zhao, Ke; Chen, Yu-Hsin; Yan, Wen-Jing; Fu, Xiaolan

2013-01-01

27

Processing map for controlling microstructure in hot working of hot isostatically pressed powder metallurgy NIMONIC AP-1 superalloy  

NASA Astrophysics Data System (ADS)

The hot deformation behavior of hot isostatically pressed (HIP) NIMONIC AP-1 superalloy is characterized using processing maps in the temperature range 950 C to 1200 C and strain rate range 0.001 to 100 s1. The dynamic materials model has been used for developing the pro-cessing maps which show the variation of the efficiency of power dissipation given by [2m / ( m + 1)] with temperature and strain rate, with m being the strain rate sensitivity of flow stress. The processing map revealed a domain of dynamic recrystallization with a peak efficiency of 40 pct at 1125 C and 0.3 s1, and these are the optimum parameters for hot working. The microstructure developed under these conditions is free from prior particle boundary (PPB) de-fects, cracks, or localized shear bands. At 100 s1 and 1200 C, the material exhibits inter-crystalline cracking, while at 0.001 s1, the material shows wedge cracks at 1200 C and PPB cracking at 1000 C. Also at strain rates higher than 10 s1, adiabatic shear bands occur; the limiting conditions for this flow instability are accurately predicted by a continuum criterion based on the principles of irreversible thermodynamics of large plastic flow.

Somani, M. C.; Rao, E. S. Bhagiradha; Birla, N. C.; Bhatia, M. L.; Singh, Vakil; Prasad, Y. V. R. K.

1992-10-01

28

AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release  

PubMed Central

Of the five mammalian muscarinic acetylcholine (ACh) receptors, M5 is the only subtype expressed in midbrain dopaminergic neurons, where it functions to potentiate dopamine release. We have identified a direct physical interaction between M5 and the AP-3 adaptor complex regulator AGAP1. This interaction was specific with regard to muscarinic receptor (MR) and AGAP subtypes, and mediated the binding of AP-3 to M5. Interaction with AGAP1 and activity of AP-3 were required for the endocytic recycling of M5 in neurons, the lack of which resulted in the downregulation of cell surface receptor density after sustained receptor stimulation. The elimination of AP-3 or abrogation of AGAP1M5 interaction in vivo decreased the magnitude of presynaptic M5-mediated dopamine release potentiation in the striatum. Our study argues for the presence of a previously unknown receptor-recycling pathway that may underlie mechanisms of G-protein-coupled receptor (GPCR) homeostasis. These results also suggest a novel therapeutic target for the treatment of dopaminergic dysfunction.

Bendor, Jacob; Lizardi-Ortiz, Jose E; Westphalen, Robert I; Brandstetter, Markus; Hemmings, Hugh C; Sulzer, David; Flajolet, Marc; Greengard, Paul

2010-01-01

29

Press releases online: the effectiveness of Calliope as an online writing center for business communication  

Microsoft Academic Search

The Calliope online writing center developed at the University of Antwerp, Belgium, provides a modular platform aimed at enhancing learners professional writing skills. Drawning from the module on press releases it is first shown how Calliope caters for different learning styles and what the main features are of its process approach. Next, we will report on a preliminary investigation into

Van Waes L; Opdenacker L; Jacobs G

2004-01-01

30

Web presence transformations in the 1990s: an analysis of press releases  

Microsoft Academic Search

Many organizations are constantly changing their web presence. Despite the frequency of these redesigns, there appears to be little evidence to explain what kinds of changes are incorporated into each updated version of a web presence. To understand how commercial organizations transform their web presence, we conduct a content analysis and a cluster analysis of press releases describing redesign initiatives

RAQUEL BENBUNAN-FICH; SHOSHANA ALTSCHULLER

2005-01-01

31

Is the press release a genre? A study of form and content  

Microsoft Academic Search

Although using different labels, genre theorists from different traditions have generally given privilege to the communicative purpose, in this article referred to as rhetorical objective, as genre determinant (see e.g. Swales, 1990; Bhatia, 1993; see also Hasan, 1989; Halliday and Martin, 1993; Eggins, 1994). Genre analysts who have studied press releases in particular (e.g. Frandsen et al., 1997; Jacobs, 1999)

Inger Lassen

2006-01-01

32

ANLISE COMPARATIVA ENTRE REPRESENTAES IDEACIONAIS NOS TTULOS DE PRESS RELEASES E DE NOTCIAS  

Microsoft Academic Search

RESUMO: Este trabalho analisa as diferenas entre os ttulos de press releases publicados por duas empresas brasileiras de telecomunicaes e de notcias correspondentes publicadas por um jornal on-line, em uma anlise comparativa feita com base na metafuno ideacional descrita pela Lingstica Sistmico-Funcional. A anlise comparativa dos ttulos identificou incluses e excluses de participantes e diferenas nas funes de transitividade atribudas

Mauro Tadeu Baptista SOBHIE

33

Corporate Responsibility in Communication: Empirical Analysis of Press Releases in a Conflict  

ERIC Educational Resources Information Center

|The paper examines how the tensions of corporate responsibility are articulated and reconciled in a controversial situation of a foreign investment. We conducted a conventionalist analysis on the company press releases in a case where a Finnish forest industry company invested in a pulp mill in South America. The findings show that the use of

Lehtimaki, Hanna; Kujala, Johanna; Heikkinen, Anna

2011-01-01

34

The Annual Earnings Press Release's Dual Role: An Examination of Relationships with Local and National Media Coverage and Reputation  

Microsoft Academic Search

This study analyzed annual earnings press releases and local and national newspaper coverage of those earnings for 207 of Fortune's America's Most Admired companies to explore intermedia agenda setting and relationships with reputation. The annual earnings press releases were found to have the greatest relationship with the positive content in local media coverage and negative content in national media coverage.

Marcia W. DiStaso

2012-01-01

35

LIST OF ETV ARTICLES AND PRESS RELEASES--ETV PUBLICATIONS AND DOCUMENTS (ENVIRONMENTAL TECHNOLOGY VERIFICATION (ETV) PROGRAM)  

EPA Science Inventory

The Environmental Technology Verification (ETV) Program produces articles and press releases related to the ETV program. This list of ETV articles and press releases will help readers stay informed of developments in the ETV Program. To view the complete list of articles and pre...

36

Reporting Medical Information: Effects of Press Releases and Newsworthiness on Medical Journal Articles' Visibility in the News Media  

Microsoft Academic Search

Background. Characteristics defining newsworthiness of journal articles appearing in JAMA and NEJM were examined to determine if they affect visibility in the news media. It was also hypothesized that press releases affected the amount of news coverage of a journal article due to the fact that the most newsworthy journal articles are selected for press releases.Methods. Journal articles (N =

Jo Ellen Stryker

2002-01-01

37

From Press Release to News: Mapping the Framing of the 2009 H1N1 A Influenza Pandemic  

Microsoft Academic Search

Pandemics challenge conventional assumptions about health promotion, message development, community engagement, and the role of news media. To understand the use of press releases in news coverage of pandemics, this study traces the development of framing devices from a government public health agency's press releases to news stories about the 2009 H1N1 A influenza pandemic. The communication management of the

Seow Ting Lee; Iccha Basnyat

2012-01-01

38

Credibility of science communication: An exploratory study of astronomy press releases  

NASA Astrophysics Data System (ADS)

Current developments in the media marketplace and an increased need for visibility to secure funding are leading inevitably to faster, simpler and more aggressive science communication. This article presents the results of an exploratory study of potential credibility problems in astronomy press releases, their causes, consequences and possible remedies. The study consisted of eleven open-ended interviews with journalists, scientists and public information officers. Results suggest that credibility issues are central to communication, deeply integrated into the workflow and can have severe consequences for the actors (especially the scientist), but are an unavoidable part of the communication process. In general a major credibility problem was not found to exist for astronomical press releases.

Nielsen, L. H.; Torpe Jrgensen, N.; Jantzen, K.; Christensen, L. L.

2008-06-01

39

An Extraction Method of Product Feature Keywords From Press Releases Using Syntactic Dependency Analysis with an Expression Phrase  

NASA Astrophysics Data System (ADS)

We propose an extraction method of product features from press releases of companies for competitor analysis. In press releases of companies, product features are described with characteristic expressions (we call description patterns). From this view point, when a description pattern is input, our system extracts features included in the pattern. Additionally, in order to extract more product features by less input patterns, our system generates similar patterns of input patterns as derivation patterns automatically and extracts product features using derivation patterns. Through application to the press releases of ten companies, it is confirmed that the accuracy of the extracted features are sufficient.

Samejima, Masaki; Shimizu, Yutaka; Akiyoshi, Masanori; Komoda, Norihisa

40

Solid-state diffusion welding of wrought AISI 304 stainless steel to Nimonic AP-1 superalloy powder by hot isostatic pressing  

SciTech Connect

The diffusion welding characteristics of wrought AISI 304 stainless steel to a superalloy powder Nimonic AP-1 were examined in this study. After encapsulation, evacuation and degassing, the welds were hot isostatically pressed (HIPed) in two different cycles, i.e., 1,200 C (2,192 F)/3h/147 MPa and 1,270 C (2,318 F)/3h/121 MPa. A variation in surface condition of stainless steel was also studied for its influence on properties of the joints. These diffusion-welded joints were characterized for diffusion of alloying elements, microstructural features and tensile properties.

Somani, M.C.; Birla, N.C. [Defence Metallurgical Research Lab., Hyderabad (India); Tekin, A. [Istanbul Technical Univ., Istanbul (Turkey). Dept. of Chemical and Metallurgical Engineering

1998-02-01

41

Ionizing radiation induced helium release for hot pressed SiC  

NASA Astrophysics Data System (ADS)

Ionizing radiation induced helium release and diffusion in SiC has been assessed. Hot pressed SiC was pre-implanted with He+ ions at 45 keV, and then mounted in a special irradiation chamber in the beam line of a Van de Graaff electron accelerator. Release of the implanted helium was measured during 1.8 MeV electron irradiation as a function of temperature (15-450 C) and irradiation time (dose), and compared with results obtained without irradiation. Ionizing radiation enhanced helium release from SiC has been clearly observed, and the relative change of He desorption as a function of ionizing radiation dose and temperature evaluated. The results are consistent with He release from discrete trapping centres.

Moroo, A.; Manzano, J.; Malo, M.; Hodgson, E. R.

2011-10-01

42

APS Receives Continued Funding from NIDDK  

NSDL National Science Digital Library

Press Release - BETHESDA, MD (September 22, 2010) The American Physiological Society (APS; www.the-APS.org) has received continued funding from the National Institute of Diabetes and Digestive and Kidney Disease (NIDDK) for an additional two years of support effective July 1, 2010. The goal of the project is to encourage highly qualified students from groups underrepresented in the biomedical/behavioral sciences (especially underrepresented minority students) to pursue professional careers in physiological/biomedical sciences.

APS Communications Office (American Physiological Society Communications Office)

2010-09-22

43

From press release to news: mapping the framing of the 2009 H1N1 A influenza pandemic.  

PubMed

Pandemics challenge conventional assumptions about health promotion, message development, community engagement, and the role of news media. To understand the use of press releases in news coverage of pandemics, this study traces the development of framing devices from a government public health agency's press releases to news stories about the 2009 H1N1 A influenza pandemic. The communication management of the H1N1 pandemic, an international news event with local implications, by the Singapore government is a rich locus for understanding the dynamics of public relations, health communication, and journalism. A content analysis shows that the evolution of information from press release to news is marked by significant changes in media frames, including the expansion and diversification in dominant frames and emotion appeals, stronger thematic framing, more sources of information, conversion of loss frames into gain frames, and amplification of positive tone favoring the public health agency's position. Contrary to previous research that suggests that government information subsidies passed almost unchanged through media gatekeepers, the news coverage of the pandemic reflects journalists' selectivity in disseminating the government press releases and in mediating the information flow and frames from the press releases. PMID:22439616

Lee, Seow Ting; Basnyat, Iccha

2012-03-22

44

Anticipating or Precipitating Crisis? Health Agencies May Not be Heeding Best Practice Advice in Avian Flu Press Releases  

Microsoft Academic Search

Precrisis information disseminated by public health information officers (PIOs) will play a critical role in preparing and safeguarding publics amidst a possible avian flu pandemic. This article analyzes avian flu press releases issued by leading health agencies, the Centers for Disease Control and Prevention, the National Institutes of Health, the Department of Health and Human Services and the World Health

Elizabeth Johnson Avery; Sora Kim

2009-01-01

45

Coverage of Team Science by Public Information Officers: Content Analysis of Press Releases about the National Science Foundation Science and Technology Centers  

ERIC Educational Resources Information Center

|This study examines the content of press releases from the National Science Foundation (NSF) Science and Technology Centers (STCs) to determine how public information officers (PIOs) presented the outcomes of centers to journalists and the public. A total of 68 press releases were analyzed for type of news covered, visibility of centers and their

Graube, Marita; Clark, Fiona; Illman, Deborah L.

2010-01-01

46

Coverage of Team Science by Public Information Officers: Content Analysis of Press Releases about the National Science Foundation Science and Technology Centers  

ERIC Educational Resources Information Center

This study examines the content of press releases from the National Science Foundation (NSF) Science and Technology Centers (STCs) to determine how public information officers (PIOs) presented the outcomes of centers to journalists and the public. A total of 68 press releases were analyzed for type of news covered, visibility of centers and their

Graube, Marita; Clark, Fiona; Illman, Deborah L.

2010-01-01

47

[The Universidad de Buenos Aires in the 1970s: analysis of the press release expressing solidarity with Rodolfo Puiggrs].  

PubMed

This article reconstructs the historical context surrounding the emission of a press release by authorities of the Universidad de Buenos Aires, expressing their solidarity with historian and university rector Rodolfo Puiggrs after his resignation. In his term, Puiggrs attempted to fuse the institution's scientific and technological plans with the new development model initiated by Hctor Cmpora and the Peronist movement in 1973. The article makes reference to the project of university transformation promoted by Puiggrs, combining the ideological traditions of Marxism, reformism, and nationalism. A few key points, useful for analyzing the reasons behind Puiggrs's resignation, are presented, and the arguments highlighted within this press release, published by Office of Media and Communications on October 5, 1973, are discussed. PMID:23681463

Recalde, Aritz

2012-12-01

48

EVALUATION OF CHEMICAL RELEASES AND WORKER EXPOSURES FROM FILTER PRESS OPERATIONS  

EPA Science Inventory

The exposures (inhalation and dermal) and releases (air, water, solids, and process streams) associated with the filtration of industrial wastewater sludge from an electronics manufacturing plant were characterized. Chemical releases and worker exposures for a target chemical (t...

49

EVALUATION OF CHEMICAL RELEASES AND WORKER EXPOSURES FROM FILTER PRESS OPERATIONS  

EPA Science Inventory

The exposures (inhalation and dermal) and releases (air, water, solids, and process streams) associated with the filtration of industrial wastewater sludge from an electronics manufacturing plant were characterized. hemical releases and worker exposures for a target chemical (tot...

50

Plutonium release from pressed plutonium oxide fuel pellets in aquatic environments  

SciTech Connect

Plutonium oxide pellets (80% /sup 238/Pu, 40 g each) were exposed to fresh water and sea water at two temperatures for 3 y in enclosed glass chambers. The concentrations of plutonium observed in the waters increased linearly with time throughout the experiment. However, the observed release rates were inversely dependent on temperature and salinity, ranging from 160 ..mu..Ci/day for cold fresh water to 1.4 ..mu..Ci/day for warm sea water. The total releases, including the chamber residues, showed similar dependencies. A major portion (typically greater than 50%) of the released plutonium passed through a 0.1-..mu..m filter, with even larger fractions (greater than 80%) for the fresh water systems.

Patterson, J.H.; Steinkruger, F.J.; Matlack, G.M.; Heaton, R.C.; Coffelt, K.P.; Herrera, B.

1983-12-01

51

Thermally induced atomic diffusion at the interface between release agent coating and mould substrate in a glass moulding press  

NASA Astrophysics Data System (ADS)

In a glass moulding press (GMP) for refractive/diffractive hybrid lenses, to improve the service life of nickel-phosphorus (Ni-P) plated moulds, it is necessary to control the diffusion of constituent elements from the mould into the release agent coating. In this study, diffusion phenomena of constituents of Ni-P plating are investigated for two types of release agent coatings, iridium-platinum (Ir-Pt) and iridium-rhenium (Ir-Re), by cross-sectional observation, compositional analysis and stress measurements. The results show that Ni atoms in the plating layer flow from regions of compressive stress to regions of tensile stress. In the case of the Ir-Pt coated mould, the diffusion of Ni is promoted from the grain boundaries between the Ni and Ni3P phases in the plating towards the surface of the Ir-Pt coating. However, in the Ir-Re coated mould, the diffusion of Ni is suppressed because the diffusion coefficient of Ni in the Ir-Re alloy is smaller than that in the Ir-Pt alloy, although the stress state is similar in both cases. By controlling the diffusion of Ni atoms, the use of Ir-Re alloy as a release agent coating for Ni-P plated moulds is expected to lead to a high degree of durability.

Masuda, Jun; Yan, Jiwang; Zhou, Tianfeng; Kuriyagawa, Tsunemoto; Fukase, Yasushi

2011-06-01

52

Press Release: The World Wide Web Consortium Issues SMIL 1.0 as a W3C Recommendation  

NSDL National Science Digital Library

The World Wide Web Consortium (W3C) has issued its first recommendation for Synchronized Multi-media Integration Language. The specification intends to help "bring television-like content to the web, avoiding the limitations for traditional television and lowering the bandwidth requirements for transmitting this type of content over the Internet. With SMIL [pronounced smile], producing audio-visual content is easy; it does not require learning a programming language and can be done using a simple text editor." Easy authorship, accessibility, and improvement of bandwidth efficiency are among a few of the promises that SMIL may bring closer to reality. The site contains a press release and more information about SMIL.

1998-01-01

53

2004 Presidential campaign messages: A functional analysis of press releases from President Bush and Senator Kerry  

Microsoft Academic Search

This study content analyzed news releases from Bush and Kerry in the 2004 election. Challenger Kerry attacked more and acclaimed less than the incumbent, Bush. Defenses were relatively rare. Candidates focused most on policy than character or campaign-related topics. When addressing policy, they discussed past deeds (53.3%), future plans (16.9%), and general goals (29.8%). When discussing character, they addressed personal

Sooyoung Cho; William Benoit

2006-01-01

54

Reciprocating pellet press  

DOEpatents

A machine for pressing loose powder into pellets using a series of reciprocating motions has an interchangeable punch and die as its only accurately machines parts. The machine reciprocates horizontally between powder receiving and pressing positions. It reciprocates vertically to press, strip and release a pellet.

Jones, Charles W. (Seminole, FL)

1981-04-07

55

Sample Press Release  

Center for Drug Evaluation (CDER)

... Always require a doctor's prescription; Provide a physical address and telephone ... may be improperly stored, made under filthy conditions, or contain ... More results from www.fda.gov/drugs/resourcesforyou/consumers

56

Individual Differences in Pavlovian Autoshaping of Lever Pressing in Rats Predict Stress-Induced Corticosterone Release and Mesolimbic Levels of Monoamines  

Microsoft Academic Search

Pavlovian autoshaping CRs are directed and reflexive consummatory responses targeted at objects repeatedly paired with rewarding substances. To evaluate the hypothesis that autoshaping may provide an animal learning model of vulnerability to drug abuse, this study relates individual differences in lever-press autoshaping CR performance in rats to stress-induced corticosterone release and tissue monoamine levels in the mesolimbic dopamine tract. LongEvans

Arthur Tomie; Allison S Aguado; Larissa A Pohorecky; Daniel Benjamin

2000-01-01

57

Exposure and release estimations for filter-press and tray-dryer operations based on pilot-plant data. Final report  

SciTech Connect

Worker exposures and chemical releases associated with a plate-and-frame filter press and a stationary tray dryer were studied in a pilot plant. The equipment was representative of those in a chemical manufacturing plant; the filter press was previously used at a chemical plant, and the dryer trays were the same size used by dye manufacturers. A randomized series of eight experiments identified the most influential variables for inhalation exposure during the tray drying unit operation which used approximately 100 kg of CaCO3. The range of conditions studied in the eight experiments provide inhalation exposure data for evaluating the impact of physical properties, the activities performed, and the influence of worker technique.

Marshall, M.C.; Howard, H.K.

1992-03-20

58

APS: The American Physical Society  

NSDL National Science Digital Library

This expansive website features the American Physical Society's (APS) work in advancing and diffusing the knowledge of physics. Visitors will find the latest APS news and releases such as the Report of the APS Study Group on Boost-Phase Intercept Systems for National Missile Defense. Teachers can learn about the APS's work in improving science education. The website features many programs and activities of the APS's outreach Committee on Minorities in Physics (COM). Students can find information on how to prepare for a career in physics from middle school through graduate work. With so much to offer, anyone interested in physics should visit this website.

59

Attention that Indicators Receive in the Press  

ERIC Educational Resources Information Center

|With the release of each edition of Education at a Glance, the Office for Economic Co-operation and Development (OECD) prepares a press briefing to be used for the international press release and which individual countries in preparing their national press releases can also use. Similarly, the European Union prepares a summary, not for use at the

Hendriks, Maria; Barzano, Giovanna; Brumana, Emanuela; Cremonesi, Claudia

2004-01-01

60

Press Seaweed  

NSDL National Science Digital Library

In this activity, learners will collect, dry and press seaweed over the course of four days in a similar way that artists/crafters press flowers. This process will encourage learners to appreciate the beauty of the colors, shapes, and structure of seaweed by pressing seaweed.

Aquarium, The F.

2010-01-01

61

Striatal dopamine release in the rat during a cued lever-press task for food reward and the development of changes over time measured using high-speed voltammetry.  

PubMed

Substantia nigra dopamine neuronal activity in the primate is thought to be related to the error in predicting reward delivery. Dopamine release in rat nucleus accumbens has been shown to increase in relation to drug/food-seeking behaviour. It is not known how the release of dopamine in the striatum corresponds to the many distinct steps of a rewarded, cued task (e.g. recognizing the cue, executing the behaviour, anticipating the reward, receiving the reward) and how dopamine release then changes over time as task performance improves. To investigate dopamine release during a rewarded, cued task and the development of changes in dopamine release over time, changes in extracellular striatal dopamine concentration during a rewarded, cued lever-press task were measured a few days every week for 5 months using high-speed in vivo voltammetry. Rats were trained to press a lever after a tone to obtain a food reward. The reaction time for the lever press decreased gradually as training continued. Changes in dopamine concentration were measured in the anterior striatum (ventral portion) during the task performance after an initial 6-day familiarization period, in which the animals learned that a lever press yielded food, and a 5-week period for surgery, recovery, and electrode preparation. During the task performance, dopamine concentration started to increase just after the cue, peaked near the time of the lever press, and returned to basal levels 1-2 s after the lever press. This pattern of changes in dopamine concentration was observed over the 5 months of testing, the peak dopamine concentration increasing steadily until peaking at week 7, at which time the task performance had not yet improved significantly from week 2. By week 13, task performance had significantly improved and peak dopamine concentration had begun to subside. Thus, the increase in dopamine concentration after the cue was highest while the task was not yet perfected and subsided toward the end of the learning process. It was concluded that striatal dopamine release during a cued lever-press task is relevant to the novelty of the conditions. PMID:16028033

Nakazato, Taizo

2005-07-19

62

EUROPA Press Room: The European Commission's On-line Press Room  

NSDL National Science Digital Library

Available in English, German, and French, the European Commission's (EC) online press room is an excellent resource for any users interested in the latest news and press releases from the EC and the European Union. At the site, visitors will find links to the latest headlines and releases (many available in multiple languages), a weekly archive, a searchable database of press releases since 1985, and links to video news, photos, and other resources. Registered users may also sign up to receive free electronic press releases on designated areas of interest.

2001-01-01

63

The AP stars  

Microsoft Academic Search

Ap stars are stars with peculiar characteristics which made it difficult to assign them to the stellar types of the conventional classification scheme. Ap stars are frequently observed. Up to 10% Ap stars are found in the case of the concerned spectral types. Attention is given to the spectroscopic properties of the Ap stars, aspects of stellar spectrum and stellar

H. Muthsam

1977-01-01

64

The Associated Press Stylebook and Libel Manual. Fully Updated and Revised.  

ERIC Educational Resources Information Center

|Pointing out that the style of the Associated Press (AP) defines clear writing, this revised edition of the practical and much-used AP stylebook is designed to be an essential handbook for all writers, editors, and students. The stylebook contains over 5000 entries laying out the AP's rules on grammar, spelling, punctuation, and usage. It gives

Goldstein, Norm, Ed.

65

The GALFA-HI Survey: Toward the Second Data Release  

NASA Astrophysics Data System (ADS)

The GALFA-HI Survey uses 21-cm spectral line data recorded with the Arecibo L-band Feed Array (ALFA), in an effort to map the neutral hydrogen content of the Galaxy and its nearby environment. The first full public release of data (Peek et al. 2011, ApJS in press) covers approximately 7500 square degrees, from observations spanning the epoch of May 2005 to February 2009. The second data release will include data from GALFA-HI observations to the end of 2010. We will describe the attributes of the survey, and most importantly, how to gain access to the data.

Douglas, Kevin A.; Peek, J. E. G.; Grcevich, J.; Saul, D.; Lee, M.; Pingel, N.; Korpela, E. J.; Stanimirovic, S.; Putman, M. E.; Gibson, S. J.; Heiles, C. E.

2011-05-01

66

How Do U.S. Medical Oncologists Learn and Apply New Clinical Trials Information from Press Releases in Nonmedical Media? A Case Study Based on ECOG 4599  

Microsoft Academic Search

Background. Practicing oncologists are expected to eas- ily assimilate large amounts of rapidly evolving clini- cal data. We hypothesized that U.S. oncologists rapidly familiarize themselves with new, practice-relevant, phase III clinical trial data. We tested this hypothesis in relation to the release of phase III data from the East- ern Cooperative Oncology Group 4599 trial on the role of bevacizumab

Daniel Dornbusch; Richard Leff; James Epstein; James Jones; Lee Lokey

67

Attacks on the Press in 2001  

NSDL National Science Digital Library

Released by the Committee to Protect Journalists (CPJ), a nonpartisan, nonprofit organization established to "monitor abuses against the press and promote press freedom around the world," Attacks on the Press 2001 documents the deaths, imprisonment, and abuses of journalists around the world within the past year. Prefaced by CPJ board member Anne Garrels with an introduction by CPJ's executive director Ann Cooper, the report contains an overview of media attacks arranged by country, along with three special press freedom reports on Syria, Burma, and Colombia. In addition, the report contains a Ten Worst Enemies of the Press section that focuses attention on individual leaders responsible for the world's worst abuses against the media. Topping the list are Supreme Leader Ayatollah Ali Khamenei of Iran, President Jiang Zemin of China, and Liberian president Charles Taylor.

2002-01-01

68

The Global University Press  

ERIC Educational Resources Information Center

|The modern world's understanding of American university press has long been shaped by university-press books. American university-press books are good international advertisements for the universities whose logos grace their spines. The growth of transnational scholarship and the expansion of digital communications networks are converging in ways

Dougherty, Peter J.

2012-01-01

69

AP and YA?  

ERIC Educational Resources Information Center

|Considers the reasons Advanced Placement (AP) English teachers might give for their literature selections. Suggests eight works for further reading outside the canon for AP and Honors English Teachers. Lists and gives annotations for 10 "new or overlooked" Young Adult books worth reading. (SG)|

Crowe, Chris

2001-01-01

70

Opening AP to All  

ERIC Educational Resources Information Center

|This article reports on a school's effort to open Advanced Placement (AP) to all by challenging its students to take the leap into AP courses. Samuel W. Wolfson High School, on the south side of Jacksonville, Florida, is one of 27 schools in five cities across the country that chose to participate in a College Board initiative called EXCELerator.

Gewertz, Catherine

2008-01-01

71

WordPress 3.0.3  

NSDL National Science Digital Library

For those looking for a way to document their experiences throughout the holiday season and the New Year, WordPress might be just the ticket. This new release of the popular blogging software contains a few new plugins, including those that are designed to synchronize posts with Twitter and the "BuddyPress", which helps users build social networks for their company, school, or sports team. This version is compatible with all operating systems, including Linux.

Boren, Ryan; Mullenweg, Matt

2010-01-01

72

Attacks on the Press in 2000  

NSDL National Science Digital Library

This recently published survey reports on the harassment, imprisonment, and death of journalists worldwide. The report is comprised of regional overviews, country summaries, and individual documented cases. There are also special sections on journalists murdered or imprisoned in the last year, the International Press Freedom Awards of 2000 (given to courageous journalists), and a press release, as well as individual reports on the state of press freedom in China, Russia, and Venezuela. The report may be viewed in HTML or .pdf formats. Earlier editions of this annual report are also available on this site, back to 1996. The preface of this most recent edition was written by Peter Arnett.

2001-01-01

73

APS Science 2006.  

SciTech Connect

In my five years as the Director of the Advanced Photon Source (APS), I have been fortunate to see major growth in the scientific impact from the APS. This year I am particularly enthusiastic about prospects for our longer-term future. Every scientific instrument must remain at the cutting edge to flourish. Our plans for the next generation of APS--an APS upgrade--got seriously in gear this year with strong encouragement from our users and sponsors. The most promising avenue that has emerged is the energy-recovery linac (ERL) (see article on page xx), for which we are beginning serious R&D. The ERL{at}APS would offer revolutionary performance, especially for x-ray imaging and ultrafast science, while not seriously disrupting the existing user base. I am very proud of our accelerator physics and engineering staff, who not only keep the current APS at the forefront, but were able to greatly impress our international Machine Advisory Committee with the quality of their work on the possible upgrade option (see page xx). As we prepare for long-term major upgrades, our plans to develop and optimize all the sectors at APS in the near future are advancing. Several new beamlines saw first light this year, including a dedicated powder diffraction beamline (11-BM), two instruments for inelastic x-ray scattering at sector 30, and the Center for Nanoscale Materials (CNM) Nanoprobe beamline at sector 26. Our partnership in the first x-ray free-electron laser (LCLS) to be built at Stanford contributes to revolutionary growth in ultrafast science (see page xx), and we are developing a pulse chirping scheme to get ps pulses at sector 7 of the APS within a year or so. In this report, you will find selected highlights of scientific research at the APS from calendar year 2006. The highlighted work covers diverse disciplines, from fundamental to applied science. In the article on page xx you can see the direct impact of APS research on technology. Several new products have emerged from work at the APS, to complement the tremendous output of work in basic science, which often has payoff in technology but over decades rather than years. Highlights in this report also reflect the relevance of APS work to Department of Energy missions, for example a route to more efficient fuel cells (page xx mr-88-073113) addresses the energy challenge, and natural approaches to cleaning up the environment.

Gibson, J. M.; Fenner, R. B.; Long, G.; Borland, M.; Decker, G.

2007-05-24

74

Classification Criteria for APS  

Microsoft Academic Search

\\u000a An international consensus statement on classification criteria for definite APS was published in 1999. A patient with APS\\u000a must meet at least one of the two clinical criteria (vascular thrombosis or pregnancy complications) and at least one of the\\u000a two laboratory criteria (aCL and\\/or LA). Although these criteria have been shown to be specific and sensitive for the classification\\u000a of

Maria Laura Bertolaccini; Oier Ateka-Barrutia; Munther A. Khamashta

75

High School Press Freedom.  

ERIC Educational Resources Information Center

|This report focuses on controversial articles written by the high school press, decisions made by the courts regarding students' press freedoms, and reactions to the articles and rulings. Particular attention is given to two rulings concerning censorship of articles about students' sexual atttiudes and activities, the issue of prior restraint of

Maurer, Diana J.

76

The Prison Press.  

ERIC Educational Resources Information Center

|The prison press in the United States operates under varying degrees of First Amendment freedom. Court decisions have been varied, and have not resolved whether convicts can produce or receive publications without censorship by prison officials. Until about 1970, censorship of the prison press was rarely challenged. Most newspapers and magazines

Hausman, John

77

Burning-rate behavior in aluminized wide-distribution AP composite propellants  

Microsoft Academic Search

Burning-rate behavior of aluminized, wide-distribution ammonium-perchlorate (AP), hydroxyl-terminated-polybutadiene (HTPB)\\u000a binder composite propellants, both 2D laminates and 3D particulate propellants, is investigated experimentally. Very fine\\u000a (2-m) AP (FAP) is used at a high FAP\\/binder ratio (75\\/25) with either coarse (>200 m) AP (CAP) particles (3D particulate\\u000a propellants) or pressed AP slabs (simulating CAP particles in over-ventilated, 2D laminates). The results indicate

M. Q. Brewster; J. C. Mullen

2011-01-01

78

Mars Exploration Rover Mission: Press Release Images  

NSDL National Science Digital Library

The public can now view the amazing, newly collected images of Mars thanks to this Mars Exploration Rover Mission website. The first images, made available on January 4, 2004, are black and white pictorials of the rover on the surface of Mars. On January 6, 2004, this website provided users with the first color images of Mars. Alongside each image, the NASA team has provided users with straightforward explanations. Everyone will enjoy these images of Spirit's descent, Mars' wind-polished rocks, the Martian Horizon, and much more.

79

APS News - April 2008  

NSDL National Science Digital Library

This is an article from The Physiologist. -APS Election Results "The American Physiological Society announces the results of the election of officers for 2008." -APS Partners with The Scientist on a Compensation Survey "The Scientist, The Magazine of the Life Sciences, is conducting a major survey of compensation in the life sciences. The survey is open to all life scientists employed in the US, and is sponsored by several major professional societies including The American Physiological Society." -Beijing Physiology 2008 "The APS membership is invited to participate in the October 19-22, 2008 joint physiology meeting in Beijing. The Society is joining with several of our sister societies to sponsor a scientific meeting in Beijing, China. "

2008-04-01

80

AP Biology Demonstrations  

NSDL National Science Digital Library

A collection of experiments and demonstrations presented by biology teachers addressing some of the most difficult-to-understand topics in the AP biology curriculum which include evolutionary traits, genetics, bacterial transformation, antibody diversity, comparative anatomy, photosynthesis, human genetics, protein synthesis, recombinant DNA and RNA polymerase.

The College Board The College Board (The College Board;)

2003-06-03

81

APS power supply controls  

SciTech Connect

The purpose of this document is to provide comprehensive coverage of the APS power supply control design. This includes application software, embedded controller software, networks, and hardware. The basic components will be introduced first, followed by the requirements driving the overall design. Subsequent sections will address each component of the design one by one. Latter sections will address specific applications.

Saunders, C.W.; Despe, O.D.

1994-03-31

82

Rod Press Fruit Harvester.  

National Technical Information Service (NTIS)

This invention relates to an apparatus for removing or harvesting fruit and more particularly to an apparatus that will harvest fruit especially from narrow fruit growing canopies by pressing the fruit out of the production canopy.

D. L. Peterson

1982-01-01

83

A School Press Notebook  

ERIC Educational Resources Information Center

|Discusses the following topics related to student publications: recent instances of censorship of student publications by student government, items seen and liked in the student press, and a well-planned front page from a college newspaper. (GW)|

Ward, Bill

1977-01-01

84

Trashing the Press.  

ERIC Educational Resources Information Center

|Discusses ominous assaults on press freedom on college campuses across the United States. Laments the lack of concern about First Amendment issues involved in these incidents, in which student newspapers have been stolen, trashed, and burned. (SR)|

McMasters, Paul

1994-01-01

85

APS Supports 24 Undergraduate Researchers  

NSDL National Science Digital Library

This article is on page 87 of The Physiologist, June 2012. The American Physiological Societys Undergraduate Summer Research Fellowships (UGSRF) program is sponsored by the APS Career Opportunities in Physiology Committee and funded by the APS Council.

APS Education Office (American Physiological Society Education Office)

2012-06-01

86

AP Calculus AB II  

NSDL National Science Digital Library

HippoCampus, a project of the Monterey Institute for Technology and Education (MITE), seeks to provide âhigh-quality, multimedia content on general education subjects to high school and college students.â This course, Advanced Placement Calculus AB II, is a continuation on the principles covered in the Advanced Placement Calculus AB I course. It contains study materials, interactive lessons, and textbooks to help students prepare for the College Board AP Calculus AB exam. Each lesson contains objectives, readings, an interactive lesson, and a test with answer key. Students can review the course material in its entirety, or simply choose a lesson that they need to review. The materials provided in this course will definitely help students to prepare for the AP Calculus exam, and can also serve as useful supplementary material for the classroom.

2008-07-11

87

APS Science 2007.  

SciTech Connect

This report provides research highlights from the Advanced Photon Source (APS). Although these highlights represent less than 10% of the published work from the APS in 2007, they give a flavor of the diversity and impact of user research at the facility. In the strategic planning the aim is to foster the growth of existing user communities and foresee new areas of research. This coming year finds the APS engaged in putting together, along with the users, a blueprint for the next five years, and making the case for a set of prioritized investments in beamlines, the accelerator, and infrastructure, each of which will be transformational in terms of scientific impact. As this is written plans are being formulated for an important user workshop on October 20-21, 2008, to prioritize strategic plans. The fruit from past investments can be seen in this report. Examples include the creation of a dedicated beamline for x-ray photon correlation spectroscopy at Sector 8, the evolution of dedicated high-energy x-ray scattering beamlines at sectors 1 and 11, a dedicated imaging beamline at Sector 32, and new beamlines for inelastic scattering and powder diffraction. A single-pulse facility has been built in collaboration with Sector 14 (BioCARS) and Phil Anfinrud at the National Institutes of Health, which will offer exceptionally high flux for single-pulse diffraction. The nanoprobe at Sector 26, built and operated jointly by the Argonne Center for Nanoscale Materials and the X-ray Operations and Research (XOR) section of the APS X-ray Science Division, has come on line to define the state of the art in nanoscience.

Not Available

2008-05-30

88

Victory for press freedom  

Microsoft Academic Search

Last month, following nationwide protests from journalists, editors and publishers, the Indian government withdrew its controversial Defamation Bill and announced that a national debate on the defamation issue would be intiated. The government's decision, announced by Prime Minister Rajiv Gandhi at the end of September, was greeted with jubilation by members of the press and public. The Bill, which would

Joseph Maliakan; Lek Hor Tan

1988-01-01

89

Student Press Archives.  

ERIC Educational Resources Information Center

|Lists the 200 issues, controversies, and court cases involving the student press that were described by John C. Behrens in the Fall 1977 issue of this journal (see EJ 173 477), and categorizes them according to 16 topics, including censorship, funding, litigations, and publication guidelines. Provides ordering information for materials relating

College Press Review, 1979

1979-01-01

90

Tower Press Camera  

USGS Multimedia Gallery

"4x5" enclosure camera with Rangefinder and Wollensak Raptar lens serial #A18388, 62 mm, 1950s-60s. Manufactured by Busch Optical Manufacturing Company, Chicago, Illinois (also known as Busch Precision Camera Corporation). The company was famous for its versatile press cameras which featured an opti...

2009-07-22

91

Free press, corporate style  

Microsoft Academic Search

The values embodied in the U.S. Constitution by the First Amendment's free speech and press clauses are often personified in less abstract images: the brusque newspaper editor fighting prejudice or corruption; the labor organizer rallying workers against their exploiters; citizens massing together to protest injustices and to sway public opinion. These images reflect the individualist ethic that has dominated U.S.

Douglas W. Vick; Nancy Morris

1996-01-01

92

AP1 function and regulation  

Microsoft Academic Search

AP-1 (activating protein-1) is a collective term referring to dimeric transcription factors composed of Jun, Fos or ATF (activating transcription factor) subunits that bind to a common DNA site, the AP-1-binding site. As the complexity of our knowledge of AP-1 factors has increased, our understanding of their physiological function has decreased. This trend, however, is beginning to be reversed due

Michael Karin; Zheng-gang Liu; Ebrahim Zandi

1997-01-01

93

Freedom of the press for the press of the future  

Microsoft Academic Search

As technology improves, a free electronic press promises to provide channels of communication, education, and debate superior both to the paper press and to the electronic media of today. It is pointed out that historical accidents have created distinctions between the electronic and traditional media which place freedom of the electronic press in serious jeopardy. The problems associated with the

K. Eric Drexler

1991-01-01

94

Thermal Decomposition Characteristics of Orthorhombic Ammonium Perchlorate (o-AP) and an 0-AP/HTPB-Based Propellant  

SciTech Connect

A study to characterize the low-temperature reactive processes for o-AP and an AP/HTPB-based propellant (class 1.3) is being conducted in the laboratory using the techniques of simultaneous thermogravimetric modulated beam mass spectrometry (STMBMS) and scanning electron microscopy (SEM). The results presented in this paper are a follow up of the previous work that showed the overall decomposition to be complex and controlled by both physical and chemical processes. The decomposition is characterized by the occurrence of one major event that consumes up to {approx}35% of the AP, depending upon particle size, and leaves behind a porous agglomerate of AP. The major gaseous products released during this event include H{sub 2}O, O{sub 2}, Cl{sub 2}, N{sub 2}O and HCl. The recent efforts provide further insight into the decomposition processes for o-AP. The temporal behaviors of the gas formation rates (GFRs) for the products indicate that the major decomposition event consists of three chemical channels. The first and third channels are affected by the pressure in the reaction cell and occur at the surface or in the gas phase above the surface of the AP particles. The second channel is not affected by pressure and accounts for the solid-phase reactions characteristic of o-AP. The third channel involves the interactions of the decomposition products with the surface of the AP. SEM images of partially decomposed o-AP provide insight to how the morphology changes as the decomposition progresses. A conceptual model has been developed, based upon the STMBMS and SEM results, that provides a basic description of the processes. The thermal decomposition characteristics of the propellant are evaluated from the identities of the products and the temporal behaviors of their GFRs. First, the volatile components in the propellant evolve from the propellant as it is heated. Second, the hot AP (and HClO{sub 4}) at the AP-binder interface oxidize the binder through reactions that preferentially strip the hydrogen from the binder and yield HCl and H{sub 2}O with some oxidation of the carbon from the binder. Third, the o-AP in the propellant decomposes in the same manner as in neat o-AP. Finally, AP-derived gaseous products interact with other ingredients in the propellant.

BEHRENS JR.,RICHARD; MINIER,LEANNA M.G.

1999-10-25

95

Inner City Press  

NSDL National Science Digital Library

Based in the South Bronx, the Inner City Press has been publishing a newspaper focused on low-income neighborhoods nationwide since 1987. A few months ago, the organization went online with a weekly publication featuring original and engaging investigative and analytical pieces from a selection of beats, including the Federal Reserve, Community Reinvestment, Insurance Redlining, Wall Street, Environmental Justice, and Banks, among others. The most recent issue (August 30) includes concise reports on predatory lending, the economic crisis in Ecuador, press leaks and the Federal Reserve, and a round-up of bank news. The site also provides overviews and related resources for Community Reinvestment, the Inner City Public Interest Law Center, Environmental Justice, Insurance Redlining, and related topics.

96

APS Archive of Teaching Resources  

NSDL National Science Digital Library

This is a powerpoint presentation from the 2008 APS Science Teaching Forum held in Warrenton, Virginia from July 21-27, 2008. The presentation describes what digital resources are, and how to access these types of materials in the APS Archive.

Amy Feuerstein (The American Physiological Society Education)

2008-06-01

97

AP-42 REVISION: COKE OVENS  

EPA Science Inventory

The document "Compilation of Air Pollutant Emission Factors" (AP-42) has been published by the U. S. Environmental Protection Agency (EPA) since 1972. Supplements to AP-42 have been routinely published to add new emission source categories and to update existing emission factor...

98

55. QUARRY TILE CUTTERS, SECOND FLOOR, NORTH WING. WORKERS PRESSED ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

55. QUARRY TILE CUTTERS, SECOND FLOOR, NORTH WING. WORKERS PRESSED THE CUTTERS INTO SLABS OF CLAY, LIFTED THEM ONTO DRYING BOARDS AND PRESSED THE PLUNGERS TO RELEASE THE CUT TILES. REPRODUCTIONS CUTTERS ARE NOT USED IN PRODUCTION. WOODEN FORMS FOR PRODUCING CLAY SLABS WITH ROLLING PINS REST AGAINST THE WALL. - Moravian Pottery & Tile Works, Southwest side of State Route 313 (Swamp Road), Northwest of East Court Street, Doylestown, Bucks County, PA

99

Hot Off the Press  

NSDL National Science Digital Library

Environmental Health Perspectives (EHP) , a peer-reviewed environmental health research journal (published by the National Institute of Environmental Health Sciences, part of the National Institutes of Health,) provides the EHP Student Edition for high school and college teachers and their students. Each edition contains news articles that summarize a wide variety of scientific information and original research, which are paired with complementary lessons that introduce students to hot-off-the-press science. This article presents ways to integrate EHP's online content in the classroom.

Schlegel, Barry; Tart, Kimberly T.; Hemminger, Laura; Pitman, Lisa; Hines, Stefani; Stephan, Wendy

2006-10-01

100

APS controls overview  

SciTech Connect

The APS accelerator control system described in this report is a distributed system consisting of operator interfaces, a network, and interfaces to hardware. The operator interface is a UNIX-based workstation with an X-windows graphical user interface. The workstation may be located at any point on the facility network and maintain full functionality. The user has the ability to generate and alter control displays and to access the alarm handler, the archiver, interactive control programs, custom code, and other tools. The TCP/EP networking protocol has been selected as the underlying protocol for the control system network. TCP/EP is a commercial standard and readily available from network hardware vendors. Its implementation is independent of the particular network medium selected to implement the controls network. In the development environment copper Ethernet is the network medium; however, in the actual implementation a fiber-based system using hub technology will be utilized. The function of the network is to provide a generalized communication path between the host computers, operator workstations, input/output crates, and other hardware that comprise the control system.

NONE

1996-02-01

101

Iran Weekly Press Digest  

NSDL National Science Digital Library

The Iran Weekly Press Digest, a weekly review of the Iranian press in English, contains a number of articles on the summit of the Organisation of the Islamic Conference and its significance for Iran in its archived and current issues. The eighth summit of the Organisation of the Islamic Conference was recently held in Tehran, Iran. Iran recently hosted representatives from 55 countries to a three-day Muslim summit in Tehran in a move which is being seen as a new phase in the country's re-emergence after years of relative isolation. The acceptance of Iran's invitations by senior figures from former enemies such as Saudi Arabia and Iraq has been portrayed by Iranian leaders and many others as a strong setback for US attempts to politically quarantine that country. Representatives considered 142 resolutions prepared by foreign ministers on issues including Middle East peace, regional conflicts, terrorism and human rights. However, perhaps the most significant outcome of the summit has been a reintroduction of Iran into the Muslim community of nations. Capitalizing on current anti-American sentiments and the recent election of a relatively moderate president, Iran hopes to rebuild its relationships with its neighbors and once again become a regional leader, a position it held for approximately 3000 years.

1997-01-01

102

Academic libraries and university presses  

Microsoft Academic Search

In recent years university presses have undergone some significant changes, such as expansion of their scope to include materials\\u000a that may have appeal beyond the scholarly market. This article investigates, through the use of a survey of university libraries,\\u000a the acquisition of university press products by libraries. In general, recent years have been changes in the relationship\\u000a between university presses

John M. Budd

1991-01-01

103

Effective temperatures of AP stars  

Microsoft Academic Search

A new method of determination of the effective temperatures of Ap stars is proposed. The method is based on the fact that the slopes of the energy distribution in the Balmer continuum near the Balmer jump for ``normal\\

N. A. Sokolov

1998-01-01

104

Stony Brook Press  

NSDL National Science Digital Library

The State University of New York at Stony Brook has an impressive set of digital collections spanning poetry, history, and geography. This particular section of the digital initiative, known as DSpace, brings together past issues of the Stony Brook Press. This institutional journal is published every two weeks, and this particular archive contains over 560 issues. It's far from dry as it reports on everything from new literary endeavors to changes within the faculty. As one of the largest schools in the state system, this school has undergone many changes in the past twenty years, and this publication is a great way to learn more about the school's history. Also it is easy to search through past issues via the advanced search option.

105

Reaction: Student Press Law Center.  

ERIC Educational Resources Information Center

Provides a reaction from the Student Press Law Center to the Hazelwood School District versus Kuhlmeier decision. Urges student journalists and advisors to continue to do their best to produce quality, intelligent publications and to educate school administration and community about the importance of a free student press. (MG)

Goodman, Mark

1988-01-01

106

The Chilean Press Since Allende.  

ERIC Educational Resources Information Center

Based on interviews with 19 Chilean editors, government officials, heads of professional associations, and journalism education directors, this paper deals with the role of the press in Chile and with its future under the current military government. Following a review of the events concerning press control and censorship that followed the

Knudson, Jerry W.

107

The Chilean Press Since Allende.  

ERIC Educational Resources Information Center

|Based on interviews with 19 Chilean editors, government officials, heads of professional associations, and journalism education directors, this paper deals with the role of the press in Chile and with its future under the current military government. Following a review of the events concerning press control and censorship that followed the

Knudson, Jerry W.

108

Warm Press Forming of Stainless Steel Sheets.  

National Technical Information Service (NTIS)

The effect of 'warm press forming' on the press formability of stainless steel sheets in deep drawing and restriking was studied. The result indicates that the press formability of both austenitic and ferritic steels is markedly improved by the compositio...

1985-01-01

109

Censorship of the Collegiate Presses.  

ERIC Educational Resources Information Center

|Enumerates determinations of the American judicial system that protect the First Amendment rights of college journalists. Reviews discussions of those determinations. Discusses recent cases of imposed collegiate press censorship. Concludes that students continue to be silenced today. (TB)|

Kasior, Serjit; Darrah, Ed

1996-01-01

110

AP Geography, Environmental Science Thrive  

ERIC Educational Resources Information Center

|Geography may not be particularly known as a hot topic among today's students--even some advocates suggest it suffers from an image problem--but by at least one measure, the subject is starting to come into its own. Across more than 30 topics covered in the Advanced Placement (AP) program, participation in geography is rising faster than any

Robelen, Erik W.

2012-01-01

111

APS beamline standard components handbook  

SciTech Connect

It is clear that most Advanced Photon Source (APS) Collaborative Access Team (CAT) members would like to concentrate on designing specialized equipment related to their scientific programs rather than on routine or standard beamline components. Thus, an effort is in progress at the APS to identify standard and modular components of APS beamlines. Identifying standard components is a nontrivial task because these components should support diverse beamline objectives. To assist with this effort, the APS has obtained advice and help from a Beamline Standardization and Modularization Committee consisting of experts in beamline design, construction, and operation. The staff of the Experimental Facilities Division identified various components thought to be standard items for beamlines, regardless of the specific scientific objective of a particular beamline. A generic beamline layout formed the basis for this identification. This layout is based on a double-crystal monochromator as the first optical element, with the possibility of other elements to follow. Pre-engineering designs were then made of the identified standard components. The Beamline Standardization and Modularization Committee has reviewed these designs and provided very useful input regarding the specifications of these components. We realize that there will be other configurations that may require special or modified components. This Handbook in its current version (1.1) contains descriptions, specifications, and pre-engineering design drawings of these standard components. In the future, the APS plans to add engineering drawings of identified standard beamline components. Use of standard components should result in major cost reductions for CATs in the areas of beamline design and construction.

Kuzay, T.M.

1992-01-01

112

Equine Infectious Anemia Virus Gag Polyprotein Late Domain Specifically Recruits Cellular AP2 Adapter Protein Complexes during Virion Assembly  

Microsoft Academic Search

We have identified an interaction between the equine infectious anemia virus (EIAV) late assembly domain and the cellular AP-2 clathrin-associated adapter protein complex. A YXXL motif within the EIAV Gag late assembly domain was previously characterized as a sequence critical for release of assembling virions. We now show that this YXXL sequence interacts in vitro with the AP-50 subunit of

BRIDGET A. PUFFER; S. C. WATKINS; RONALD C. MONTELARO

1998-01-01

113

Advanced APS Impacts on Vehicle Payloads.  

National Technical Information Service (NTIS)

Advanced auxiliary propulsion system (APS) technology has the potential to both, increase the payload capability of earth-to-orbit (ETO) vehicles by reducing APS propellant mass, and simplify ground operations and logistics by reducing the number of fluid...

S. J. Schneider B. D. Reed

1989-01-01

114

The AE9/AP9 Next Generation Radiation Specification Models  

NASA Astrophysics Data System (ADS)

A significant effort is under way to develop the next-generation trapped proton and electron models for satellite design, AP-9 and AE-9, respectively. The primary objectives of the effort are to 1) improve the overall accuracy of the models; 2) provide indicators of the uncertainty in the model due to natural variability and instrument uncertainty; 3) cover a broad energy range including hot plasma, relativistic electrons and highly energetic protons; and 4) provide complete spatial coverage. This paper describes the completed and released version 1.0 and developments for future releases.

O'Brien, Paul; Byers, David; Johnston, William Robert; Ginet, Gregory; Huston, Stuart

2012-07-01

115

Update on autoimmune polyendocrine syndromes (APS)  

Microsoft Academic Search

Autoimmune Polyendocrine Syndromes (APS) were initially defined as a multiple endocrine gland insufficiency associated to an autoimmune disease in a patient. Neufeld & Blizzard (1980) suggested a classification of APS, based on clinical criteria only, describing four main types. APS-1 is characterized by presence of chronic candidiasis, chronic hypoparathyroidism, Addison's disease. It is a very rare syndrome in- teresting young

Corrado Betterle; Renato Zanchetta

2003-01-01

116

64 FR 27626 - AP600 Design Certification  

Federal Register 2010, 2011, 2012, 2013

...10 CFR Part 52 AP600 Design Certification; Proposed Rule Federal...COMMISSION 10 CFR Part 52 RIN 3150-AG23 AP600 Design Certification AGENCY: Nuclear Regulatory...regulations to certify the AP600 standard plant design under Subpart B of 10 CFR Part 52....

1999-05-20

117

64 FR 72002 - AP600 Design Certification  

Federal Register 2010, 2011, 2012, 2013

...COMMISSION 10 CFR Part 52 RIN 3150-AG23 AP600 Design Certification AGENCY: Nuclear Regulatory...regulations to certify the AP600 standard plant design under Subpart B of 10 CFR part 52. This...intending to construct and operate an AP600 design may do so by referencing this...

1999-12-23

118

71 FR 4464 - AP1000 Design Certification  

Federal Register 2010, 2011, 2012, 2013

...10 CFR Part 52 RIN 3150-AH56 AP1000 Design Certification AGENCY: Nuclear Regulatory...regulations to certify the AP1000 standard plant design. This action is necessary so that applicants...intending to construct and operate an AP1000 design may do so by referencing this...

2006-01-27

119

70 FR 20062 - AP1000 Design Certification  

Federal Register 2010, 2011, 2012, 2013

...10 CFR Part 52 RIN 3150-AH56 AP1000 Design Certification AGENCY: Nuclear Regulatory...regulations to certify the AP1000 standard plant design. This action is necessary so that applicants...intending to construct and operate an AP1000 design may do so by referencing the...

2005-04-18

120

Antiprogestin-releasing intrauterine devices: a novel approach to endometrial contraception  

Microsoft Academic Search

Intrauterine devices (IUDs) that release progestins are highly effective contraceptives, but they induce breakthrough bleeding that some women find unacceptable. Because progesterone (P) antagonists [antiprogestins (APs)] are known to suppress the endometrium, induce amenorrhea and inhibit fertility, AP-releasing IUDs (AP-IUDs) may provide an effective contraceptive that also controls endometrial bleeding. Here, we assessed the effects of empty (blank) vs. AP-IUDs

Nihar R. Nayak; Ov D. Slayden; Kunie Mah; Kristof Chwalisz; Robert M. Brenner

2007-01-01

121

AP1 activation through endogenous H 2O 2 generation by alveolar macrophages  

Microsoft Academic Search

Reactive oxygen species released during the respiratory burst are known to participate in cell signaling. Here we demonstrate that hydrogen peroxide produced by the respiratory burst activates AP-1 binding. Stimulation of the macrophage cell line NR8383 with respiratory burst agonists ADP and C5a increased AP-1 binding activity. Importantly, this increase in binding was blocked by catalase, confirming mediation by endogenous

Karen E. Iles; Dale A. Dickinson; Nobuo Watanabe; Takeo Iwamoto; Henry Jay Forman

2002-01-01

122

Sherwood/APS 2006 Conference  

SciTech Connect

The International Sherwood Theory Meeting is a yearly meeting that focuses on the theory of magnetically confined fusion plasmas. There are many topics of common interest in fusion plasma systems and space and astrophysical plasmas. These common topics include such key topics as magnetic reconnection, the dynamo, turbulence and transport and particle heating and acceleration. One of the major participants of the April APS meeting is the APS Division of Astrophysics (DAP). The goal of having the Sherwood Meeting jointly with the April meeting was to promote discussion of topics of common interest in fusion and space and astrophysics. Scientists from the DAP, the Division of Plasma Physics (DPP), the Topical Group on Plasma Astrophysics (GPAP) and Sherwood worked together closely to produce a joint program that addressed areas of common interest. Four sessions of invited talks were sponsored jointly by the DAP, DPP and GPAP on laboratory experiments related to astrophysics. Plasma scientists working in theory and computation play a key role in connecting these laboratory experiments to the very disparate conditions found in fusion and astrophysical systems. Thus, the attendees of the Sherwood Theory meeting were critical to facilitating this effort at cross-disciplinary communication. Noteworthy were the selection of two of the prestigious plenary talks at the joint meeting on plasma topics - one related to the gyrokinetic modeling of turbulence and the other related to the structure of collisionless shocks. It is rare to see even a single plenary talk on plasma physics at the APS April Meeting. There were additional costs associated with hosting a joint meeting. The Office of Fusion Energy Sciences contributed $3000 in partial support of this meeting. This funding covered part of the costs of the poster boards and A. V. equipment that was used in the presentation of nearly 200 scientific papers related to magnetically confined fusion plasmas. The APS waived its indirect costs on this funding as part of their effort to support this joint meeting.

James F. Drake

2009-07-28

123

The APS control system network  

SciTech Connect

The APS accelerator control system is a distributed system consisting of operator interfaces, a network, and computer-controlled interfaces to hardware. This implementation of a control system has come to be called the {open_quotes}Standard Model.{close_quotes} The operator interface is a UNDC-based workstation with an X-windows graphical user interface. The workstation may be located at any point on the facility network and maintain full functionality. The function of the network is to provide a generalized communication path between the host computers, operator workstations, input/output crates, and other hardware that comprise the control system. The crate or input/output controller (IOC) provides direct control and input/output interfaces for each accelerator subsystem. The network is an integral part of all modem control systems and network performance will determine many characteristics of a control system. This paper will describe the overall APS network and examine the APS control system network in detail. Metrics are provided on the performance of the system under various conditions.

Sidorowicz, K.V.; McDowell, W.P.

1995-12-31

124

Dynamics of intracellular clathrin/AP1 and clathrin/AP3 containing carriers  

PubMed Central

Clathrin/AP1 and clathrin/AP3 coated vesicular carriers originate from endosomes and the TGN. We report here the real-time visualization of these structures in living cells reliably tracked by using rapid, three-dimensional imaging with a spinning-disk confocal microscope. We imaged relatively sparse, diffraction-limited, fluorescent objects containing chimeric fluorescent protein (clathrin light chain, ? adaptor subunits or dynamin2) with a spatial precision of up to ~ 30 nm and a temporal resolution of ~ 1 sec. The dynamic characteristics of the intracellular clathrin/AP1 and clathrin/AP3 carriers are similar to those of endocytic clathrin/AP2 pits and vesicles; the clathrin/AP1 coats are, on average, slightly shorter-lived than their AP2 and AP3 counterparts. We confirmed that while dynamin2 is recruited as a burst to clathrin/AP2 pits immediately before their budding from the plasma membrane, we found no evidence supporting a similar association of dynamin2 with clathrin/AP1 or clathrin/AP3 carriers at any stage during their lifetime. We found no effects of chemical inhibitors of dynamin function or the K44A dominant negative mutant of dynamin on AP1 and AP3 dynamics. This observation suggests that an alternative budding mechanism, yet to be discovered, is responsible for the scission step of clathrin/AP1 and clathrin/AP3 carriers.

Kural, Comert; Tacheva-Grigorova, Silvia K.; Boulant, Steeve; Cocucci, Emanuele; Baust, Thorsten; Duarte, Delfim; Kirchhausen, Tom

2012-01-01

125

Dynamics of intracellular clathrin/AP1- and clathrin/AP3-containing carriers.  

PubMed

Clathrin/AP1- and clathrin/AP3-coated vesicular carriers originate from endosomes and the trans-Golgi network. Here, we report the real-time visualization of these structures in living cells reliably tracked by rapid, three-dimensional imaging with the use of a spinning-disk confocal microscope. We imaged relatively sparse, diffraction-limited, fluorescent objects containing chimeric fluorescent protein (clathrin light chain, ? adaptor subunits, or dynamin2) with a spatial precision of up to ~30 nm and a temporal resolution of ~1 s. The dynamic characteristics of the intracellular clathrin/AP1 and clathrin/AP3 carriers are similar to those of endocytic clathrin/AP2 pits and vesicles; the clathrin/AP1 coats are, on average, slightly shorter-lived than their AP2 and AP3 counterparts. We confirmed that although dynamin2 is recruited as a burst to clathrin/AP2 pits immediately before their budding from the plasma membrane, we found no evidence supporting a similar association of dynamin2 with clathrin/AP1 or clathrin/AP3 carriers at any stage during their lifetime. We found no effects of chemical inhibitors of dynamin function or the K44A dominant-negative mutant of dynamin on AP1 and AP3 dynamics. This observation suggests that an alternative budding mechanism, yet to be discovered, is responsible for the scission step of clathrin/AP1 and clathrin/AP3 carriers. PMID:23103167

Kural, Comert; Tacheva-Grigorova, Silvia K; Boulant, Steeve; Cocucci, Emanuele; Baust, Thorsten; Duarte, Delfim; Kirchhausen, Tom

2012-10-25

126

Development of an air-injection press for preventing blowout of particleboard I: effects of an air-injection press on board properties  

Microsoft Academic Search

An air-injection press was developed to prevent particleboard from blowing out during the manufacturing process. The air-injection\\u000a press, which has holes punched in the heating plates, injects high-pressure air into the board through the holes of one plate\\u000a and releases the air through the holes of the other plate. The high-pressure air forces out vapor trapped within the board,\\u000a thus

Hideaki Korai; Nan Ling; Takayoshi Osada; Osamu Yasuda; Atsushi Sumida

127

Censorship and the Student Press.  

ERIC Educational Resources Information Center

|The First Amendment rights provided to journalists--freedom of speech and of the press--are fundamental beliefs held by Americans. What students learn in the government class, however, may not be what they learn as editors-in-chief of student newspapers. U.S. schools are being charged with the censorship of student publications at an

Oettinger, Lauren

128

Gifted Education Press Quarterly, 1995.  

ERIC Educational Resources Information Center

This document consists of the four issues of the newsletter "Gifted Education Press Quarterly" published during 1995. This newsletter addresses issues in the education of gifted children and youth. The major articles are: (1) "Using Today's Technology: Parents Can Help Challenge Gifted Children" (Adrienne O'Neill); (2) "Outcomes-Based Education

Fisher, Maurice D., Ed.

1995-01-01

129

A Conversation with Frank Press  

Microsoft Academic Search

Geophysicist Frank Press was director of Caltech's Seismological Laboratory from 1957 to 1965. In this interview, he recalls his work with Maurice Ewing at Columbia's Lamont Geological Observatory; his directorship of Caltech's Seismological Laboratory and colleagues Charles Richter, Beno Gutenberg, and Hugo Benioff; his work on the free oscillations of the earth; and his part in establishing the worldwide network

Judith R. Goodstein

2004-01-01

130

National Academy Press: New Books  

NSDL National Science Digital Library

This site will keep users abreast of the latest publications from the National Academy Press (NAP), the publishing arm of the National Academy of Science, National Academy of Engineering, Institute of Medicine, and the National Research Council. The New Books sites provides annotated descriptions of recent publications.

Press., National A.

131

Press Reports of Animal Hoarding  

Microsoft Academic Search

This article explores how the press reports nonhuman animal hoarding and hoarders. It discusses how 100 articles from 1995 to the present were content analyzed. Analysis revealed ve emotional themes that include drama, revulsion, sympathy, indig- nation, and humor. While these themes draw readers' attention and make disparate facts behind cases understandable by pack- aging them in familiar formats,

Arnold Arluke; Randy Frost; Gail Steketee; Gary Patronek; Carter Luke; Edward Messner; Jane Nathanson; Michelle Papazian

2002-01-01

132

Hot Isostatic Pressing of Ceramics.  

National Technical Information Service (NTIS)

A mixture containing glass 70 to 95 and BN or B4C powder (0.1-10 microns) 5 to 30 vol. % is used as a secondary pressure medium in hot isostatic pressing of ceramics. Thus, Pyrex beads were mixed with 15% vol. BN powder (average diameter 2 microns), fused...

K. Honma

1985-01-01

133

Mars Observer Press Conference JPL  

NASA Astrophysics Data System (ADS)

The Mars Observer mission spacecraft was primarily designed for exploring Mars and the Martian environment. The Mars Observer was launched on September 25, 1992. The spacecraft was lost in the vicinity of Mars on August 21, 1993 when the spacecraft began its maneuvering sequence for Martian orbital insertion. This videotape shows a press briefing, held after the spacecraft had not responded to attempts to communicate with it, to explain to the press the problems and the steps that were being taken to re-establish communication with the spacecraft. The communications had been shutdown prior to the orbital insertion burn to protect the instruments. At the time of the press conference, the communications system was still not operational, and attempts were being made to re-establish communication. Bob McMillan of the Public Affairs Office at JPL gives the initial announcement of the continuing communication problem with the spacecraft. Mr. McMillan introduces William Piotrowski, acting director of solar system exploration, who reiterates that there is indeed no communication with the Observer spacecraft. He is followed by Glenn Cunningham, the Project Manager of the Mars Observer who speaks about the attempts to re-establish contact. Mr. Cunningham is followed by Satenios Dallas, the Mission Manager for the Mars Observer Project, who speaks about the sequence of events leading up to the communication failure, and shows an animated video presenting the orbital insertion maneuvers. The briefing was then opened up for questions from the assembled press, both at JPL and at the other NASA Centers. The questions are about the possible reasons for the communication failure, and the attempts to restore communications with the spacecraft. Dr. Arden L. Albee, chief scientist for the Mars Observer Mission, joins the other panel members to answer questions. At the end of the press briefing the animation of the Mars orbital insertion is shown again.

1993-08-01

134

NASA radiation belt models AP-8 and AE-8  

NASA Astrophysics Data System (ADS)

Empirical models AP-8 and AE-8 for the trapped protons and electrons in the Earth's radiation belts are currently available from NSSDC. These are the culmination of a series of models developed by J. I. Vette and colleagues. The initial models were begun in the mid-sixties with the most recent model, AE-8, being released in 1980. These models are based on data ranging from 1958 to 1970. They have been well documented by TREND, a group working under a contract with ESA, contains some information on this model. The only models which are still available from NSSDC are the most recent proton and electron models AP-8 and AE-8. A brief summary is presented of the modeling efforts to date based on information from Lemaire, Spjeldvik, and Rothwell. Results from AE8MAX, results from the models previously used at GL (AE6MAX + AEI7HI), and results from code provided by NSSDC are compared.

Jordan, Carolyn E.

1989-09-01

135

Freedom of the Press and Social Responsibility Theory  

Microsoft Academic Search

Journalism is having a hard time. People's reliance on the press has been replaced by a critical look at the press. What does it mean for the press to be free, and to be responsible? Examining freedom of the press and social responsibility of the press in A Free and Responsible Press (1947), Four Theories of the Press (1963), and

Takatoshi HIRAISHI

136

ELECTROCHEMICAL CORROSION TESTING OF TANKS 241-AN-102 & 241-AP-107 & 241-AP-108 IN SUPPORT OF ULTRASONIC TESTING  

SciTech Connect

This report presents the results of the corrosion rates that were measured using electrochemical methods for tanks 241-AN-102 (AN-102), 241-AP-107 (AP 107), and 241-AP-108 (AP-108) performed under test plant RPP-PLAN-38215. The steel used as materials of construction for AN and AP tank farms was A537 Class 1. Test coupons of A537 Class 1 carbon steel were used for corrosion testing in the AN-107, AP-107, and AP-108 tank waste. Supernate will be tested from AN-102, AP-107, and Ap-108. Saltcake testing was performed on AP-108 only.

WYRWAS RB; DUNCAN JB

2008-11-20

137

Nuclear Criticality Safety Analysis of Isostatic Press.  

National Technical Information Service (NTIS)

In response to your request a nuclear criticality safety analysis was done for the isostatic press for conditions that were specified. Under normal conditions the press is subcritical by a large margin. It is considered remotely possible, however, that th...

H. K. Clark

1988-01-01

138

How to Press and Preserve Plants  

NSDL National Science Digital Library

In this Biodiversity Counts activity, students learn how to press and preserve plant specimens. The online page includes illustrated instructions about how to layer and maintain pressings until the specimens have dried.

139

Freedom of the Press vs. Public Access.  

National Technical Information Service (NTIS)

The report reviews the constitutional rights and restraints of the press, especially in the age of electronic media. It discusses the roles of radio and television in conjunction with press freedom, and the constitutionality of government intervention.

B. C. Schmidt

1976-01-01

140

Naltrexone for extended-release injectable suspension ...  

Center for Drug Evaluation (CDER)

... Related Information. FDA approves injectable drug to treat opioid-dependent patients [ARCHIVED] FDA press release (10/12/2010); ... More results from www.fda.gov/drugs/drugsafety/postmarketdrugsafetyinformationforpatientsandproviders

141

A Conversation with Frank Press  

NASA Astrophysics Data System (ADS)

Geophysicist Frank Press was director of Caltech's Seismological Laboratory from 1957 to 1965. In this interview, he recalls his work with Maurice Ewing at Columbia's Lamont Geological Observatory; his directorship of Caltech's Seismological Laboratory and colleagues Charles Richter, Beno Gutenberg, and Hugo Benioff; his work on the free oscillations of the earth; and his part in establishing the worldwide network of seismographs for the detection of nuclear weapons testing.

Goodstein, Judith R.

142

A Conversation with Frank Press  

Microsoft Academic Search

Geophysicist Frank Press was director of Caltechs Seismological Laboratory from 1957 to 1965. In this interview, he recalls his work with Maurice Ewing at Columbias Lamont Geological Observatory; his directorship of Caltechs Seismological Laboratory and colleagues Charles Richter, Beno Gutenberg, and Hugo Benioff; his work on the free oscillations of the earth; and his part in establishing the worldwide network

Judith R. Goodstein

2004-01-01

143

The Egyptian Press: An Official Fourth Estate.  

ERIC Educational Resources Information Center

A descriptive study based on Egyptian law, printed sources, and interviews clarifies our picture of the Egyptian Press by examining its status as a constitutionally mandated "Fourth Estate." The constitutional amendment, the resultant Egyptian Press Law, and the "Law Of Shame" (all passed in 1980), are designed to create a heavily controlled press

Lawhorne, Clifton O.

144

The Small Book Press: A Cultural Essential.  

ERIC Educational Resources Information Center

|Discussion of small literary book publishers notes works of small-press authors (Thomas Paine, Washington Irving, Walt Whitman, Mark Twain, Upton Sinclair, Anais Nin); today's outstanding presses (Creative Arts Book Company, Persea Books, Full Court Press, Reed and Cannon Company, Tuumba Books); and role of little magazines. Thirty-seven

Henderson, Bill

1984-01-01

145

Automated Handling of Garments for Pressing.  

National Technical Information Service (NTIS)

The overall objective of this project is to acquire the knowledge necessary for a totally automated pressing system which loads a complete garment or sub-assembly on a form, smooths it for pressing and unloads the press. This will be achieved in three yea...

A. Schorr

1991-01-01

146

College Student Press Freedom and Student Services.  

ERIC Educational Resources Information Center

|Reviews court decisions affecting censorship and freedom of the student press at public and private colleges. Considers recent attempts at censorship and their outcomes. Discusses links between freedom of the press on campus and student personnel services. Outlines areas in which student personnel workers can help safeguard press freedom on

Salazar, Pamela Reed

1986-01-01

147

The Burger Court and the Press.  

ERIC Educational Resources Information Center

|This report discusses recent cases involving freedom of the press that have been heard before the Burger court of the United States Supreme Court. The report discerns a trend toward treating the press like an ordinary citizen; this is a reversal of the view of the Warren court that the First Amendment creates special rights for the press so that

Higdon, Philip R.

148

Failure of plastic press release buttons in automobile seat belts  

Microsoft Academic Search

In the late 1980s and early 1990s Honda, Nissan, Mitsubishi, Mazda, Suzuki, Subaru, Isuzu and Daihatsu and other automobile manufacturers modified their restraint system seat belt buckle assemblies in several models of vehicles. These automobile manufacturers incorporated plastic seat belt buckle assemblies manufactured by Takata Corporation as the 52 and A7 model series [National Highway Transportation Safety Administration (NHTSA), 1997,

Russell F. Dunn; Richard H. McSwain; Terry Mills; Brian Malone

2005-01-01

149

Press Release: Monday 2nd March Election of New Fellows  

Microsoft Academic Search

The Royal Society of Edinburgh (RSE) is pleased to announce the election of 44 new UK and International Fellows to its almost 1500-strong Fellowship of experts in the Sciences, Arts, Humanities, the Professions, Industry and Commerce. The new Fellows were elected after a rigorous four-stage selection process culminating in a ballot of the entire Fellowship. Each new Fellow of the

Marc Steven; Padma Kant; Douglas Crombie ANDERSON; Paul Reid

150

The AE9/AP9 Next Generation Radiation Specification Models  

NASA Astrophysics Data System (ADS)

A significant effort is under way to develop the next-generation trapped proton and electron models for satellite design, AP-9 and AE-9, respectively. The primary objectives of the effort are to 1) improve the overall accuracy of the models; 2) provide indicators of the uncertainty in the model due to natural variability and instrument uncertainty; 3) cover a broad energy range including hot plasma, relativistic electrons and highly energetic protons; and 4) provide complete spatial coverage. In this paper we will present background, demonstration and initial feedback from a limited-release beta version of the model.

O'Brien, Paul; Ginet, Gregory; Huston, Stuart; Byers, David

151

AP3: cooperative, decentralized anonymous communication  

Microsoft Academic Search

This paper describes a cooperative overlay network that provides anonymous communication services for participat - ing users. The Anonymizing Peer-to-Peer Proxy (AP3) sys- tem provides clients with three primitives: (i) anonymous message delivery, (ii) anonymous channels, and (iii) secur e pseudonyms. AP3 is designed to be lightweight, low-cost and provides \\

Alan Mislove; Gaurav Oberoi; Ansley Post; Charles Reis; Peter Druschel; Dan S. Wallach

2004-01-01

152

The status of APS, BESSRC, and NEET.  

SciTech Connect

We present a brief summary of the current status of the Advanced Photon Source (APS) at Argonne National Laboratory and of the facilities at two of the APS sectors operated by the Basic Energy Sciences Synchrotrons Radiation Center (BESSRC). This is followed by a report on recent measurements at BESSRC on the phenomenon of Nuclear Excitation by Electronic Transition (NEET).

Ahmad, I.; Dunford, R. W.; Esbensen, H.; Gemmell, D. S.; Kanter, E. P.; Kraessig, B.; Rutt, U.; Southworth, S. H.

1999-03-10

153

AP-42 ADDITIONS AND REVISIONS - WILDLAND FIRES  

EPA Science Inventory

This project is aimed at consolidating, selecting, and disseminating the most appropriate data and methods for estimating air emissions from wildfires and prescribed burns. The product will replace a current section of AP-42, but may not take the precise form of an AP-42 secti...

154

APS Activities with Other Professional Societies  

Microsoft Academic Search

In 1981, the APS Council issued a statement that opposed ``equal time'' presentation in public school science classes of creationism and evolution. The statement clarified that ``Scientific inquiry and religious beliefs are two distinct elements of the human experience. Attempts to present them in the same context can only lead to misunderstandings of both.'' The APS Council revisited the issue

Francis Slakey

2006-01-01

155

THE APS GAVEL MEETS A NEW BLOCK  

Technology Transfer Automated Retrieval System (TEKTRAN)

This is a summary on the history of the gavel and the block of the American Pomological Society (APS). In 2001, Dr. David Ferree, Emeritus Professor from the Ohio State University, Ohio Agricultural Research and Development Center, Wooster, Ohio, presented a gavel to the APS. He made this wooden gav...

156

APS News: Limerick Contest Finalists & Winners  

NSDL National Science Digital Library

This article from the March 1997 issue of APS News Online contains the finalists and winners of the first APS Physics Limerick Contest. Twenty-five humorous limericks concentrated on classical and modern physics concepts are provided along with a link to view the remaining submissions.

2006-09-29

157

Picturing Afghan WomenA Content Analysis of AP Wire Photographs During the Taliban Regime and after the Fall of the Taliban Regime  

Microsoft Academic Search

This study content analyzes the depiction of Afghan women in AP (Associated Press) photographs during the Taliban regime and after the fall of the Taliban regime. Analysis is based on visual subordination, point of view, social distance, imaginary contact, behavior and general portrayal. Findings suggest despite signs of visual subordination and framing stereotypes, women after the fall of the Taliban

Shahira Fahmy

2004-01-01

158

UW Madison Libraries: Parallel Press  

NSDL National Science Digital Library

UW-Madison Libraries' Parallel Press combines book publishing traditions with new technology to provide print-on-demand books and a series of chapbooks (small, inexpensive books featuring the works of authors and poets with a Wisconsin connection). Print-on-demand books parallel the online editions created by the Libraries' digitizing initiatives. Currently, four titles, including David Hayman's A First-Draft Version of Finnegan's Wake (originally published in 1963) and The Book of Beasts (1954), by T.H. White, are available via Parallel Press print-on-demand service. The poetry chapbook series began in 1999 with the publication of four Wisconsin poets (Elizabeth Oness, Max Garland, Katharine Whitcomb, and Andrea Potos) and has continued with six chapbooks per year. A prose chapbook series began in 2002 with American Trilogy. This chapbook consists of historical reproductions of the American Declaration of Independence, Constitution, and Bill of Rights, with introductory material by UW Professor Stephen E. Lucas, and an afterword by John P. Kaminski, Director of the Center for the Study of the American Constitution -- published as part of a one year later, university-wide reflection, on the impact of the Sept. 11, 2001, terrorist attacks.

159

Role of AP1 and Gadkin in the traffic of secretory endo-lysosomes  

PubMed Central

Whereas lysosome-related organelles (LRO) of specialized cells display both exocytic and endocytic features, lysosomes in nonspecialized cells can also acquire the property to fuse with the plasma membrane upon an acute rise in cytosolic calcium. Here, we characterize this unconventional secretory pathway in fibroblast-like cells, by monitoring the appearance of Lamp1 on the plasma membrane and the release of lysosomal enzymes into the medium. After sequential ablation of endocytic compartments in living cells, we find that donor membranes primarily derive from a late compartment, but that an early compartment is also involved. Strikingly, this endo-secretory process is not affected by treatments that inhibit endosome dynamics (microtubule depolymerization, cholesterol accumulation, overexpression of Rab7 or its effector Rab-interacting lysosomal protein [RILP], overexpression of Rab5 mutants), but depends on Rab27a, a GTPase involved in LRO secretion, and is controlled by F-actin. Moreover, we find that this unconventional endo-secretory pathway requires the adaptor protein complexes AP1, Gadkin (which recruits AP1 by binding to the ?1 subunit), and AP2, but not AP3. We conclude that a specific fraction of the AP2-derived endocytic pathway is dedicated to secretory purposes under the control of AP1 and Gadkin.

Laulagnier, Karine; Schieber, Nicole L.; Maritzen, Tanja; Haucke, Volker; Parton, Robert G.; Gruenberg, Jean

2011-01-01

160

Role of AP1 and Gadkin in the traffic of secretory endo-lysosomes.  

PubMed

Whereas lysosome-related organelles (LRO) of specialized cells display both exocytic and endocytic features, lysosomes in nonspecialized cells can also acquire the property to fuse with the plasma membrane upon an acute rise in cytosolic calcium. Here, we characterize this unconventional secretory pathway in fibroblast-like cells, by monitoring the appearance of Lamp1 on the plasma membrane and the release of lysosomal enzymes into the medium. After sequential ablation of endocytic compartments in living cells, we find that donor membranes primarily derive from a late compartment, but that an early compartment is also involved. Strikingly, this endo-secretory process is not affected by treatments that inhibit endosome dynamics (microtubule depolymerization, cholesterol accumulation, overexpression of Rab7 or its effector Rab-interacting lysosomal protein [RILP], overexpression of Rab5 mutants), but depends on Rab27a, a GTPase involved in LRO secretion, and is controlled by F-actin. Moreover, we find that this unconventional endo-secretory pathway requires the adaptor protein complexes AP1, Gadkin (which recruits AP1 by binding to the ?1 subunit), and AP2, but not AP3. We conclude that a specific fraction of the AP2-derived endocytic pathway is dedicated to secretory purposes under the control of AP1 and Gadkin. PMID:21525240

Laulagnier, Karine; Schieber, Nicole L; Maritzen, Tanja; Haucke, Volker; Parton, Robert G; Gruenberg, Jean

2011-04-27

161

Improving Dryer and Press Efficiencies Through Combustion of Hydrocarbon Emissions  

SciTech Connect

Emission control devices on dryers and presses have been legislated into the industry, and are now an integral part of the drying system. These devices consume large quantities of natural gas and electricity and down-sizing or eliminating them will provide major energy savings. The principal strategy taken here focuses on developing process changes that should minimize (and in some cases eliminate) the need for controls. A second approach is to develop lower-cost control options. It has been shown in laboratory and full-scale work that Hazardous Air Pollutants (HAPs) emerge mainly at the end of the press cycle for particleboard, and, by extension, to other prod-ucts. Hence, only the air associated with this point of the cycle need be captured and treated. A model for estimating terpene emissions in the various zones of veneer dryers has been developed. This should allow the emissions to be concentrated in some zones and minimized in others, so that some of the air could be directly released without controls. Low-cost catalysts have been developed for controlling HAPs from dryers and presses. Catalysts conventionally used for regenerative catalytic oxidizers can be used at much lower temperatures for treating press emissions. Fluidized wood ash is an especially inexpensive mate-rial for efficiently reducing formaldehyde in dryer emissions. A heat transfer model for estimating pinene emissions from hot-pressing strand for the manufacture of flakeboard has been constructed from first principles and validated. The model shows that most of the emissions originate from the 1-mm layer of wood adjoining the platen surface. Hence, a simple control option is to surface a softwood mat with a layer of hardwood prior to pressing. Fines release a disproportionate large quantity of HAPs, and it has been shown both theo-retically and in full-scale work that particles smaller than 400 ???µm are principally responsible. Georgia-Pacific is considering green-screening their furnish at several of their mills in order to remove these particles and reduce their treatment costs.

Sujit Banerjee

2005-10-31

162

Tank 241-AP-107, grab samples, 7AP-99-1, 7AP-99-3 and 7AP-99-4 analytical results for the final report  

SciTech Connect

This document is the format IV, final report for the tank 241-AP-107 (AP-107) grab samples taken in May 1999 to address waste compatibility concerns. Chemical, radiochemical, and physical analyses on the tank AP-107 samples were performed as directed in Compatibility Grab Sampling and Analysis Plan for Fiscal year 1999. Any deviations from the instructions provided in the tank sampling and analysis plan (TSAP) were discussed in this narrative. Interim data were provided earlier to River Protection Project (RPP) personnel, however, the data presented here represent the official results. No notification limits were exceeded.

BELL, K.E.

1999-08-12

163

Slurry-pressing consolidation of silicon nitride  

SciTech Connect

A baseline slurry-pressing method for a silicon nitride material is developed. The Si3N4 composition contained 5.8 wt percent SiO2 and 6.4 wt percent Y2O3. Slurry-pressing variables included volume percent solids, application of ultrasonic energy, and pH. Twenty vol percent slurry-pressed material was approximately 11 percent stronger than both 30 vol percent slurry-pressed and dry-pressed materials. The Student's t-test showed the difference to be significant at the 99 percent confidence level. Twenty volume percent (300 h) slurry-pressed test bars exhibited strengths as high as 980 MPa. Large, columnar beta-Si3N4 grains caused failure in the highest strength specimens. The improved strength correlated with better structural uniformity as determined by radiography, optical microscopy, and image analysis.

Sanders, W.A.; Kiser, J.D.; Freedman, M.R.

1988-11-01

164

Agenda building role of news releases in corporate takeovers  

Microsoft Academic Search

This study examines how particular characteristics of news releases influence the media's news decisions. The hostile takeover attempt by Tustin, California-based MAI\\/Basic Four (MBF) to acquire a controlling interest in Natick, Massachusetts-based Prime Computer provides an arena in which to study journalists' use of companies' press releases.In order to measure the effectiveness of each company's press releases, the study, using

Coral M Ohl; J. David Pincus; Tony Rimmer; Denise Harrison

1995-01-01

165

Army Prisoner Population Prediction Study (AP3).  

National Technical Information Service (NTIS)

The Army Prisoner Prediction Study (AP3) consists of the development of a methodology and associated model to provide the Army Correctional System proponent with an analytic managerial tool to assist in the management of the correctional system. The model...

R. M. Miller S. H. Miller

1983-01-01

166

APS Activities with Other Professional Societies  

NASA Astrophysics Data System (ADS)

In 1981, the APS Council issued a statement that opposed ``equal time'' presentation in public school science classes of creationism and evolution. The statement clarified that ``Scientific inquiry and religious beliefs are two distinct elements of the human experience. Attempts to present them in the same context can only lead to misunderstandings of both.'' The APS Council revisited the issue in 1999 when a school board in Kansas attempted to eliminate the Big Bang, among other issues, from the science curriculum. Since that time, the APS has been more directly involved in confronting efforts that would dilute the teaching of science in public school science classes. This talk will review the APS activities and describe a developing multi-science society activity.

Slakey, Francis

2006-03-01

167

APS Forum on Education Newsletter Summer 2008  

NSDL National Science Digital Library

The summer 2008 edition of the Forum on Education newsletter includes links to a number of education related talks presented at the 2008 APS March Meeting and 2008 APS April Meeting. In the teacher preparation section, Laurie E. McNeil discusses starting a teacher preparation program at the University of North Carolina - Chapel Hill and Laird Kramer details the use of learning communities at Florida International University. Monica Plisch examines the use of teacher preparation to fulfill the NSF's Broader Impact requirement.

2008-09-12

168

APS Council Holds Fall Council Meeting  

NSDL National Science Digital Library

This is an article from The Physiologist. The APS Council held their fall meeting at the Scottsdale Marriott at McDowell Mountains, Scottsdale, AZ, November 8-9, 2007. Council received reports from the Publications, Finance, Membership, Education, and other Committees. APS staff members Marsha Matyas, Robert Price, Alice Raanan, and Margaret Reich joined the meeting to assist with the committee report presentations.

2008-02-01

169

Multiplicity of Rapidly Oscillating Ap Stars  

NASA Astrophysics Data System (ADS)

Rapidly oscillating Ap (roAp) stars have rarely been found in binary or higher order multiple systems. We intend to study the multiplicity of this type of chemically peculiar star, looking for visual companions in the range of angular separation between 0.?05 and 8?. We carried out a survey of 28 roAp stars using diffraction-limited near-infrared imaging with NAOS-CONICA at the Very Large Telescope (VLT). Additionally, we observed three non-oscillating magnetic Ap stars. We detected a total of six companion candidates with low chance projection probabilities. Four of these are new detections, the other two are confirmations. An additional 39 companion candidates are very likely to be chance projections. We also found one binary system among the non-oscillating magnetic Ap stars. The detected companion candidates have K magnitudes between 6.?8 and 19.?5 and angular separations ranging from 0.?24 to 8.?9. corresponding to linear projected separations of 30-2000 AU. While our study confirms that roAp stars are indeed not very often members of binary or multiple systems, we have found four new companion candidates, which are likely to be physical companions.

Schller, M.; Correia, S.; Hubrig, S.; Kurtz, D. W.

2012-09-01

170

Elastic properties of hot-isostatically-pressed magnesium diboride  

NASA Astrophysics Data System (ADS)

Magnesium diboride was hot-isostatically pressed using three qualitatively different cycles: dense material cooled under pressure (DMCUP), ``standard'' cycle with pressure and temperature simultaneously reduced, and isothermal pressure release. Elastic properties of dense MgB2 were measured at normal conditions using resonant ultrasound spectroscopy method. The highest values of elastic moduli correspond to the sample processed using DMCUP cycle. The data for fully dense samples are in satisfactory agreement with theoretical predictions based on quantum mechanics calculations. The effect of lower density on elastic constants is consistent with a theoretical approach based on elasticity theory taking into account effect of porosity.

Nesterenko, V. F.; Gu, Y.

2003-06-01

171

Gagging the Press through Participant and Closure Orders: The Aftermath of Nebraska Press Association v. Stuart  

Microsoft Academic Search

In Nebraska Press Association v. Stuart the Supreme Court held that trial courts trying to minimize prejudicial publicity to preserve a fair trial must consider alternatives less drastic than gagging the press. This comment will examine post- Nebraska Press cases involving orders that restrict the flow of information concerning judicial proceedings and will suggest standards that focus on whether an

Valerie Bell

1979-01-01

172

Pharmaceutical development, quality control, stability and compatibility of a parenteral lyophilized formulation of the investigational polymer-conjugated platinum antineoplastic agent AP5346.  

PubMed

AP5346 is a low molecular weight polymer-conjugated platinum antineoplastic agent. The lyophilized drug product has completed a phase I clinical trial. In order to guarantee a constant quality of AP5346 pharmaceutical products, quality control and analysis of the drug substance and final product were performed. The identity of AP5346 was confirmed using 1H NMR, 195Pt NMR and IR spectroscopy. Furthermore, the free platinum content, platinum release characteristics, molecular size and size distribution were established. With the selected analytical techniques, AP5346 could be distinguished very well from its polymeric analogues, such as AP5280 and AP5279. Stability experiments revealed that AP5346 final product is stable for 12 months at 5 degrees C, in the dark. For administration to patients, AP5346 final product is reconstituted with 5% w/v dextrose and diluted in infusion containers. To investigate the influence of container materials, the stability of AP5346 after reconstitution and dilution in infusion containers was determined. The infusion containers investigated were composed of glass, polyvinyl chloride (PVC, intraflex) and low density polyethylene (LD-PE, Ecoflac). AP5346 was shown to be stable after reconstitution and dilution with 5% w/v dextrose in these infusion containers for at least 96 h at 2-8 degrees C in the dark and at room temperature with ambient light conditions. PMID:17069422

Van der Schoot, S C; Nuijen, B; Sood, P; Thurmond, K B; Stewart, D R; Rice, J R; Beijnen, J H

2006-10-01

173

The Press and the Committee System  

Microsoft Academic Search

Committees rely on the press to inform the public about their proceedings and decisions; the press relies on committees, their members and staffs as sources of information. Committee members expect their committee work to further their career and to enhance their reputation. Reporters, in addition to competing for the news, feel they have a critical function to perform. What results

Mary Russell

1974-01-01

174

Freedom of the Press and Black Publications.  

ERIC Educational Resources Information Center

Traces the history of the Black press in the United States from pre-Civil War abolitionist literature through the civil rights movement of the 1960s. Discusses both legal and nonofficial efforts to silence Black opinion through repression of the press. (GC)

Snorgrass, J. William

1980-01-01

175

Freedom of the Press and Black Publications.  

ERIC Educational Resources Information Center

|Traces the history of the Black press in the United States from pre-Civil War abolitionist literature through the civil rights movement of the 1960s. Discusses both legal and nonofficial efforts to silence Black opinion through repression of the press. (GC)|

Snorgrass, J. William

1980-01-01

176

Press, censorship, and communication in South Africa  

Microsoft Academic Search

Robert Godlonton - a man seen by many as the real founder of an indigenous Afrikaans and English Press - is also remembered for his efforts to bring about a free Press which would, through communication, promote the interests not just of one section of South Africa.In this article the crucial role of communication as a vehicle for finding peaceful

H. W. Tyson

1987-01-01

177

1979: The Campus Student Press in America.  

ERIC Educational Resources Information Center

|Discusses a number of topics involving the campus press, including the independence of campus publications, censorship issues, the relationship between the student press and the college administrator, the financing of student newspapers, yearbook production and financing, probable future student publications trends, and the need for appropriate

Ingelhart, Louis E.

1979-01-01

178

Evaluating the aluminum content of pressed dross  

NASA Astrophysics Data System (ADS)

Pressing of skimmed hot drosses in a press is a very popular technology for cooling hot dross and obtaining the maximum in-house recovery of aluminum alloy. As a result of the pressing action, part of the molten aluminum alloy is squeezed out, while the rest of the free metal remains in the pressed skulls. Thus, pressed skulls are a valuable waste product, consisting of 30 70 wt.% free aluminum. Other constituents are aluminum oxide and oxides of alloying metals. Pressed skulls are generally valued on a free-metal recovery basis, which necessarily involves practical determination of their free aluminum content. Because most analytical methods are limited to the laboratory level and representative sub-samples, there is a practical interest in developing a routine, cost-effective, and non-destructive method to predict the free aluminum content in entire pressed skulls, based on their density. To develop such a method, a relation between the bulk density, porosity, and free aluminum content of pressed skulls was established. This article offers a review of those experiments and an analysis of their results.

Kevorkijan, V.

2002-02-01

179

Freedom of the Press vs. Public Access.  

ERIC Educational Resources Information Center

|This book surveys the implications of freedom of the press for a constitutionally rooted public right of access to electronic and print media. Part one provides general perspectives on access to the media, including discussions of access in relation to the Supreme Court, to First Amendment history and theory, to current perceptions of the press,

Schmidt, Benno C., Jr.

180

Parlament und Presse im Zeitalter Max Webers  

Microsoft Academic Search

At the beginning of the twentieth century the German sociologist Max Weber regarded the new mass phenonmenon of the press as of major interest for sociological research. In 190910 he put forward two proposals for collaborative research on a grand scale into the place of the press in society, culture and politics. Only his own lawsuit with a newspaper, and

CRISTIANA SENIGAGLIA

2002-01-01

181

Freedom of the Press vs. Public Access.  

ERIC Educational Resources Information Center

This book surveys the implications of freedom of the press for a constitutionally rooted public right of access to electronic and print media. Part one provides general perspectives on access to the media, including discussions of access in relation to the Supreme Court, to First Amendment history and theory, to current perceptions of the press,

Schmidt, Benno C., Jr.

182

Teenagers as Victims in the Press  

ERIC Educational Resources Information Center

|Research into press reporting on young people has tended to concentrate on young people as offenders. In contrast, this article focuses on press coverage of teenagers as victims. Reports in two Swedish newspapers (a morning broadsheet and an evening tabloid) were studied over a period of four months and subjected to a qualitative analysis of

Andersson, Gunvor; Lundstrom, Tommy

2007-01-01

183

Multiplicity of rapidly oscillating Ap stars  

NASA Astrophysics Data System (ADS)

Context. Rapidly oscillating Ap (roAp) stars have rarely been found in binary or higher order multiple systems. This might have implications for their origin. Aims: We intend to study the multiplicity of this type of chemically peculiar stars, looking for visual companions in the range of angular separation between 0.05 arcsec and 8''. Methods: We carried out a survey of 28 roAp stars using diffraction-limited near-infrared imaging with NAOS-CONICA at the VLT. Additionally, we observed three non-oscillating magnetic Ap stars. Results: We detected a total of six companion candidates with low chance projection probabilities. Four of these are new detections, the other two are confirmations. An additional 39 companion candidates are very likely chance projections. We also found one binary system among the non-oscillating magnetic Ap stars. The detected companion candidates have apparent K magnitudes between 6.8m and 19.5m and angular separations ranging from 0.23 arcsec to 8.9 arcsec, corresponding to linear projected separations of 30-2400 AU. Conclusions: While our study confirms that roAp stars are indeed not very often members of binary or multiple systems, we have found four new companion candidates that are likely physical companions. A confirmation of their status will help understanding the origin of the roAp stars. Based on observations obtained at the European Southern Observatory, Paranal, Chile (ESO programme Nos. 079.D-0537(A) and 076.C-0170).Appendix A is available in electronic form at http://www.aanda.org

Schller, M.; Correia, S.; Hubrig, S.; Kurtz, D. W.

2012-09-01

184

Formulation and evaluation of press coated tablets for pulsatile drug delivery using hydrophilic and hydrophobic polymers.  

PubMed

The aim of present investigation was to develop press coated tablet for pulsatile drug delivery of ketoprofen using hydrophilic and hydrophobic polymers. The drug delivery system was designed to deliver the drug at such a time when it could be most needful to patient of rheumatoid arthritis. The press coated tablets containing ketoprofen in the inner core was formulated with an outer shell by different weight ratio of hydrophobic polymer (micronized ethyl cellulose powder) and hydrophilic polymers (glycinemax husk or sodium alginate). The release profile of press coated tablet exhibited a lag time followed by burst release, in which outer shell ruptured into two halves. Authors also investigated factors influencing on lag time such as particle size and viscosity of ethyl cellulose, outer coating weight and paddle rpm. The surface morphology of the tablet was examined by a scanning electron microscopy. Differential scanning calorimeter and Fourier transformed infrared spectroscopy study showed compatibility between ketoprofen and coating material. PMID:19881269

Rane, Ashish Babulal; Gattani, Surendra Ganeshlal; Kadam, Vinayak Dinkar; Tekade, Avinash Ramrao

2009-11-01

185

Ligand-selective photodissociation from [Ru(bpy)(4AP)4]2+: a spectroscopic and computational study.  

PubMed

The new complex [Ru(bpy)(4AP)(4)](2+) (1), where bpy = 2,2'-bipyridine and 4AP = 4-aminopyridine, undergoes selective photodissociation of two 4APs upon light excitation of the metal-ligand-to-ligand charge-transfer (MLLCT) band at 510 nm. The photoproducts of the reaction are mer-[Ru(bpy)(4AP)(3)(H(2)O)](2+) (2a) and trans-(4AP)[Ru(bpy)(4AP)(2)(H(2)O)(2)](2+) (3a). Photodissociation occurs in two consecutive steps with quantum yields of phi(1) = (6.1 +/- 1.0) x 10(-3) and phi(2) = (1.7 +/- 0.1) x 10(-4), respectively. Complex 1 was characterized by combined spectroscopic and theoretical techniques. EXAFS experiments at the Ru K-edge (22 117 eV) of 1 in an aqueous solution gave a Ru-N distance of 2.09 +/- 0.01 A. Photoproducts were characterized by electronic spectroscopy, 1D and 2D NMR, and mass spectrometry. Singlet and triplet excited states of 1 were studied by density functional theory (DFT) and time-dependent DFT for characterizing the optical properties of the complex. In the singlet state, (1)MC (metal-centered) dissociative states lie 0.65 eV above the main (1)MLLCT transition in the visible region of the UV-vis absorption spectrum. In the triplet state, the energy difference between these states is not reduced. However, potential energy curves of singlet and triplet excited states of 1 along the Ru-N(axial 4AP) and Ru-N(equatorial 4AP) stretching coordinates show that the release of the first 4AP may occur from the triplet state by mixing of (3)MLLCT and (3)MC dissociative states. This mixing is favored when the Ru-N(equatorial 4AP) bond is elongated, explaining the formation of the photoproduct 2a. PMID:19149466

Salassa, Luca; Garino, Claudio; Salassa, Giovanni; Nervi, Carlo; Gobetto, Roberto; Lamberti, Carlo; Gianolio, Diego; Bizzarri, Ranieri; Sadler, Peter J

2009-02-16

186

AP Powerhouse Creates High Expectations for Dallas Students: Spreading the AP Challenge to Students and Teachers.  

ERIC Educational Resources Information Center

Describes how veteran teacher Joan Vinson has made Advanced Placement (AP) a "cool thing to do" for minority students. With the help of private funding and a Texas-size enthusiasm, she is also convincing more teachers to take on the AP challenge, with a focus on quality over quantity. (EV)

Nelson, Colleen McCain

2001-01-01

187

Tank 241-AP-107, grab samples 7AP-97-1, 7AP-97-2 and 7AP-97-3 analytical results for the final report  

SciTech Connect

This document is the final report for tank 241-AP-107 grab samples. Three grab samples were collected from riser 1 on September 11, 1997. Analyses were performed on samples 7AP-97-1, 7AP-97-2 and 7AP-97-3 in accordance with the Compatibility Grab Sampling and Analysis Plan (TSAP) (Sasaki, 1997) and the Data Quality Objectives for Tank Farms Waste Compatibility Program (DQO) (Rev. 1: Fowler, 1995; Rev. 2: Mulkey and Nuier, 1997). The analytical results are presented in the data summary report (Table 1). A notification was made to East Tank Farms Operations concerning low hydroxide in the tank and a hydroxide (caustic) demand analysis was requested. The request for sample analysis (RSA) (Attachment 2) received for AP-107 indicated that the samples were polychlorinated biphenyl (PCB) suspects. Therefore, prior to performing the requested analyses, aliquots were made to perform PCB analysis in accordance with the 222-S Laboratory administrative procedure, LAP-101-100. The results of this analysis indicated that no PCBs were present at 50 ppm and analysis proceeded as non-PCB samples. The results and raw data for the PCB analysis will be included in a revision to this document. The sample breakdown diagrams (Attachment 1) are provided as a cross-reference for relating the tank farm customer identification numbers with the 222-S Laboratory sample numbers and the portion of sample analyzed.

Steen, F.H.

1997-12-22

188

Regulation of atriopeptin release from the isolated rat heart  

SciTech Connect

Recent studies have demonstrated that the mammalian atria possess an endocrine function which appears to play a role in the regulation of systemic arterial pressure, fluid balance, and electrolyte homeostasis. They have begun to study the regulation of atriopeptin (atrial natriuretic factor) release into the coronary effluent of the isolated perfused rat heart. Characterization by high pressure liquid chromatography of the form of the hormone released indicates that the predominant form is the active low MW circulating hormone not the pro-hormone. The release of immunoreactive atriopeptin (iAP) was stimulated by infusion of norepinephrine (1 ..mu..M) or epinephrine (1 ..mu..M) 3.0 and 2.6-fold, respectively. The ..beta..-adrenergic agonist isoproterenol and the ..cap alpha..-2 adrenergic agonist BHT-920 lacked effects on iAP release. On the other hand, the ..cap alpha..-1 adrenergic agonist phenylephrine caused a dose-dependent increase in release of iAP. Release of iAP stimulated by phenylephrine was inhibited by the ..cap alpha.. antagonist phentolamine. Further, iAP release was stimulated 4.2-fold by phorbol ester (1 ..mu..M) but was not affected by 4-..beta.. phorbol (1 ..mu..M). From these collective data they conclude that the release of atriopeptin is stimulated by ..cap alpha..-1 receptor activation and that protein kinase C participates in the regulation of secretion. The data suggests that the sympathetic nervous system may play a physiologic role in the regulation of atriopeptin secretion.

Currie, M.G.; Newman, W.H.

1986-03-05

189

State Education Performance Chart, 1989. Remarks of Lauro F. Cavazos, U.S. Secretary of Education, Prepared for Delivery at Press Conference.  

ERIC Educational Resources Information Center

|This press release documents the remarks made by Lauro F. Cavazos (U.S. Secretary of Education) at a press conference publicizing the 1989 edition of the "State Education Performance Chart." This chart provides comparative data for the years 1982 and 1988. It is reported that in 1988, the performance of U.S. students was stagnant. Increases in

Cavazos, Lauro F.

190

Course Does a Critical Study of Press in Capitalist Society.  

ERIC Educational Resources Information Center

|Describes a course that documents in often laborious and relatively uncritical detail the history of the Canadian press and its American and British antecedents. Describes a course on the contemporary press consisting of various forms of press criticism. (HTH)|

Winter, James

1986-01-01

191

Adaptor protein complexes AP-4 and AP-5: new players in endosomal trafficking and progressive spastic paraplegia.  

PubMed

The adaptor proteins (APs) are a family of five heterotetrameric complexes with important functions in vesicle trafficking. While the roles of APs 1-3 are broadly established, comparatively little is known about AP-4 and AP-5. Current evidence suggests that AP-4 mediates TGN to endosome transport of specific cargo proteins, such as the amyloid precursor protein APP, and that it is involved in basolateral sorting in polarized cells. Furthermore, several independent studies have reported human patients with mutations in AP-4 genes. AP-4 deficiency causes severe intellectual disability and progressive spastic para- or tetraplegia, supporting an important role for AP-4 in brain function and development. The newly discovered AP-5 complex appears to be involved in endosomal dynamics; its precise localization and function are still unclear. Intriguingly, AP-5 deficiency is also associated with progressive spastic paraplegia, suggesting that AP-5, like AP-4, plays a fundamental role in neuronal development and homeostasis. The unexpected phenotypic parallels between AP-4 and AP-5 patients may in turn suggest a functional relationship of the two APs in vesicle trafficking. PMID:23167973

Hirst, Jennifer; Irving, Carol; Borner, Georg H H

2012-12-07

192

Attacks on The Press in 1998  

NSDL National Science Digital Library

This annual report of the CPJ documents worldwide physical and political abuses of journalists. The report provides information on journalists murdered or imprisoned; the ten worst offending political leaders; special reports on the treatment of the press in Nigeria, Latin America, Southeast Asia, Algeria, and the Republics of the former Soviet Union; previous annual reports; an annotated listing of germane CPJ publications; a review of the 1998 International Press Freedom Awards; and a discussion of how CPJ investigates and classifies attacks. "The Committee to Protect Journalists is a nonpartisan organization of journalists dedicated to the defense of press freedom around the world", last discussed in

1999-01-01

193

32 CFR 635.11 - Release of information under the Freedom of Information Act (FOIA).  

Code of Federal Regulations, 2013 CFR

...INVESTIGATIONS LAW ENFORCEMENT REPORTING Release of Information § 635.11 Release of information under the Freedom of Information Act (FOIA). (a) The...b) FOIA requests from members of the press will be coordinated with the...

2013-07-01

194

32 CFR 635.11 - Release of information under the Freedom of Information Act (FOIA).  

Code of Federal Regulations, 2010 CFR

...INVESTIGATIONS LAW ENFORCEMENT REPORTING Release of Information § 635.11 Release of information under the Freedom of Information Act (FOIA). (a) The...b) FOIA requests from members of the press will be coordinated with the...

2009-07-01

195

32 CFR 635.11 - Release of information under the Freedom of Information Act (FOIA).  

Code of Federal Regulations, 2010 CFR

...INVESTIGATIONS LAW ENFORCEMENT REPORTING Release of Information § 635.11 Release of information under the Freedom of Information Act (FOIA). (a) The...b) FOIA requests from members of the press will be coordinated with the...

2010-07-01

196

28 CFR 540.64 - Press pools.  

Code of Federal Regulations, 2013 CFR

...PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT CONTACT WITH PERSONS IN THE COMMUNITY Contact With News Media § 540.64 Press...newspapers; and (4) All media in the local community where the institution is located. If...

2013-07-01

197

Bibliography on Hot Isostatic Pressing (HIP) Technology.  

National Technical Information Service (NTIS)

This report contains an annotated bibliography of 950 documents on the Hot Isostatic Pressing (HIP) Technology dealing with metals, alloys, and intermetallic compounds and covers over 450 materials. Documents published from 1966 to early 1992 are covered....

B. F. Gilp C. Y. Ho J. F. Radavich P. D. Desai

1992-01-01

198

The Press and Journals in Communist China.  

National Technical Information Service (NTIS)

A general discussion is presented of the development of newspaper and journal enterprises in Communist China. The author begins by reviewing the political role that the Chinese press played in the Republican revolution of 1911. Then the author traces the ...

A. P. L. Liu

1966-01-01

199

Tank 241-AP-106, grab samples, 6AP-96-1 through 6AP-96-3 analytical results for the final report  

SciTech Connect

This document is the final report for tank 241-AP-106 grab samples. This document presents the analytical results for three samples (6AP-96-1, 6AP-96-2 and 6AP-96-3) taken from riser 1 @ 150{degrees} of tank 241-AP-1 06 on September 12, 1996. Analyses were performed in accordance with the Compatibility Grab Sampling and Analysis Plan (TSAP) (Sasaki, 1996) and the Data Quality Objectives for Tank Farms Waste Compatibility Program (DQO) (Fowler, 1995).

Esch, R.A., Westinghouse Hanford

1996-12-11

200

Low Noise Control of Servo Press  

Microsoft Academic Search

To achieve higher accuracy and lower the noise in punching, AC servo motor was employed in press. The slider-crank mechanism is widely used as the core of the mechanical press. Dynamic model of the slider-crank mechanism was established through Lagrange equation and computed-torque control technology was chosen to regulate the motion of the mechanism in punching process. Simulation results revealed

Xingsong Wang; Qing Ma; Zhidan Zhu

2007-01-01

201

Press-fit Connector for Automobile ECUs  

Microsoft Academic Search

A press-fit connector for automobile airbag electronic control units (ECUs) was developed and transferred to the mass- production phase by Sumitomo Wiring Systems, Ltd. and AutoNetworks Technologies, Ltd. in 2005. A press-fit connection is a solderless electrical connection technology, which utilizes the mechanical contact force generated between through-holes on a printed circuit board (PCB) and terminals with a width slightly

Y. Nomura; Y. Saitoh; K. Furukawa; Y. Minami; K. Horiuchi; Y. Hattori

2006-01-01

202

Cherokee Independent Press Act of 2000  

Microsoft Academic Search

Prior to the 1997 constitutional crisis of the Cherokee Nation of Oklahoma, journalists working for the tribes Cherokee Phoenix and Indian Advocate, then called the Cherokee Advocate, did not have any press freedoms similar to the First Amendment. However, the 2-year crisis led to a revision of the tribes constitution, out of which sprang the first Independent Press Act for

Rebecca J. Tallent; Rubell S. Dingman

2011-01-01

203

APS Forum on Education Summer 2006 Newsletter  

NSDL National Science Digital Library

The APS Forum on Education (FEd) Summer 2006 Newsletter's Teacher Preparation Section articles included:The Learning Assistant Model for Teacher Education in Science and Technology by Valerie Otero,Undergraduate Learning Assistants at the University of Arkansas by Gay Stewart, andCreating and Sustaining a Teaching and Learning Professional Community at Seattle Pacific University by Lane Seeley and Stamatis Vokos.

2007-09-07

204

Adrenal insufficiency complicated with antiphospholipid syndrome (APS).  

PubMed

We describe a 69-year-old woman with bilateral adrenal hemorrhage complicated with antiphospholipid syndrome (APS). She was hospitalized with nausea and vomiting in September 2003. Laboratory data demonstrated hyponatremia, hypoglycemia and prolongation of activated partial thromboplastin time (aPTT). Abdominal computed tomography showed bilateral adrenal enlargement. In October 2003, she demonstrated altered mental status with progressive hyponatremia, a high level of ACTH, and a low level of serum cortisol. She also showed thrombocytopenia, anti-cardiolipin IgG antibody, anti-beta2GPI antibody, and lupus anticoagulants. After four months, anti-cardiolipin IgG antibody was still positive. Based on these findings, she was diagnosed as having APS complicated with adrenal insufficiency due to hemorrhagic infarction. After treatment with corticosteroid, a low dose of aspirin and normal saline infusion, her condition quickly improved. Platelet counts and aPTT were also normalized. To our knowledge, this is the second Japanese case of APS complicated with bilateral adrenal hemorrhage. APS should be considered an important underlying cause of adrenal insufficiency. PMID:16974059

Fujishima, Naohito; Komatsuda, Atsushi; Ohyagi, Hideaki; Fujishima, Masumi; Tada, Mitsunori; Ohtani, Hiroshi; Wakui, Hideki; Hirokawa, Makoto; Sawada, Ken-ichi

2006-09-15

205

Gapminder: An AP Human Geography Lab Assignment  

ERIC Educational Resources Information Center

|This lesson is designed as a lab assignment for Advanced Placement (AP) Human Geography students wherein they use the popular Gapminder web site to compare levels of development in countries from different world regions. For this lesson, it is important for the teacher to practice with Gapminder before giving the assignment to students. (Contains

Keller, Kenneth H.

2012-01-01

206

Building a Robust A-P Axis  

PubMed Central

Since the last common ancestor of Metazoa, animals have evolved complex body plans with specialized cells and spatial organization of tissues and organs. Arguably, one of the most significant innovations during animal evolutionary history was the establishment of a bilateral plane of symmetry on which morphological features (e.g. tissues, organs, appendages, skeleton) could be given specific coordinates within the animal along the anterior-posterior (A-P) and dorsal-ventral (D-V) axes. Hox genes are a known group of eumetazoan transcription factors central to regulating A-P patterning, but less well known and under current investigation is the broader regulatory landscape incorporating these genes, including microRNA (miRNA) regulation. The degree to which evolutionarily conserved targeting of Hox genes by Hox-embedded miRNAs contributes directly to A-P patterning is under investigation, yielding contrasting information dependent on the organism and miRNA of interest. The widespread A-P patterning defects observed in recent miR-196 loss-of-function studies solidifies the importance of miRNA regulation in Hox genetic hierarchies, and elucidating the developmental and evolutionary importance of all Hox-embedded miRNAs remains a challenge for the future.

Heimberg, Alysha; McGlinn, Edwina

2012-01-01

207

Top-up operation experience at APS.  

National Technical Information Service (NTIS)

The Advanced Photon Source (APS) is a 7-GeV, third-generation synchrotron radiation source. To provide more stable beam for users, in September 1998 the authors began commissioning a new operating mode called 'top-up.' In this mode, the beam current does ...

L. Emery

1999-01-01

208

Boosting Black Academic Achievement and AP Enrollments  

ERIC Educational Resources Information Center

|Minority students were about 25% of the student population at Central High School in Omaha, Nebraska, in 1995. But the composition of its honors and challenge classes did not reflect this diversity: Few minority students were taking challenge classes as underclassmen and even fewer were taking Advanced Placement (AP) courses as seniors. This

Saunders, Terrie; Maloney, Kathy

2005-01-01

209

Press briefing: Science with the Hubble Space Telescope  

NASA Astrophysics Data System (ADS)

From 4 to 9 December 1995, about three hundred scientists from around the world will gather for a conference in Paris to present and discuss the most exciting discoveries that they are making in observing planets, stars, nebulae, galaxies and distant quasars with the unprecedented clear focus of the Hubble Space Telescope. A special session of the conference (Saturday 9 December) has been arranged to discuss ways for bringing these new results into the classroom and to the general public. At the start of the conference, some of the most distinguished participants will present to the media their views on the impact that this new data is having on our understanding of the universe. A press release concerning the discovery of a new black hole in a galaxy will be distributed and commented on by the author. Photographic material and narrative description will be included in the press kit that will be distributed. Media representatives are invited to attend the press briefing on Monday 4 December at ESA Headquarters (programme attached), and are kindly requested to fill in and return the attached registration form preferably by fax to the Public Relations Division (Fax. +33 1 53 69 76 90). Later that same day, at 19:00 hours, in Room XII at UNESCO (7 place de Fontenoy, 75007 Paris), Professor Roger Bonnet, the Director of the ESA Science Programme and Dr. Duccio Macchetto, Associate Director for scientific programs at the Space Telescope Science Institute in Baltimore, will present an overview of ESA's science programmes and the exciting results obtained by the Hubble Space Telescope. This public event is free and no pre- registration is needed in order to attend.. (*) a project of international cooperation between NASA and ESA. Science with the Hubble Space Telescope Press Briefing Monday 4 December 1995 09:45 - 13:00 hrs European Space Agency Headquarters 8-10 rue Mario Nikis Paris Room A 09:45 hrs Arrival. 10:00- 10:15 hrs Overview, European Space Agency science programme. Prof. Roger Bonnet, ESA science programmes director. 10:15- 10:30 hrs Overview, Hubble Space Telescope Program. Dr. John Campbell, Director of Flight Projects, NASA Goddard Space Flight Center. 10:40- 11:00 hrs The age of the universe. Prof. Gustav Tamman, Institute of Astronomy, University of Basel, Switzerland. 11:00- 11:20 hrs Distant galaxies and quasars. Prof. Malcolm Longhair, Mullard Radio Astronomy Observatory, Cambridge, England. Supernovae. Prof. Robert Kirshner, Harvard University, Cambridge, Massachussets. Special press announcement. A black hole in Galaxy NGC 4261. Prof. Holland Ford, John Hopkins University, Baltimore, Maryland.

1995-11-01

210

Advanced APS (Auxiliary Propulsion System) Impacts on Vehicle Payloads.  

National Technical Information Service (NTIS)

Advanced auxiliary propulsion system (APS) technology has the potential to both, increase the payload capability of earth-to-orbit (ETO) vehicles by reducing APS propellant mass, and simplify ground operations and logistics by reducing the number of fluid...

S. J. Schneider B. D. Reed

1989-01-01

211

AP-42 ADDITIONS AND REVISIONS - RESIDENTIAL WOOD COMBUSTION  

EPA Science Inventory

This project develops emission factors, etc., for residential fireplaces and woodstoves which are incorporated into AP-42. AP42 is a massive collection of material which describes processes which generate air emissions and presents emission factors and control effectiveness infor...

212

The Independent Significance of the Press Clause under Existing Law  

Microsoft Academic Search

The paper argues that only the assumption that the Press Clause has a meaning independent of the Speech Clause could explain either different First Amendment treatment of individuals and the press or different First Amendment treatment of the press and other businesses. Suggesting an interpretation of the Press Clause as protecting the institutional integrity of the Fourth Estate, it then

C. Edwin Baker

2007-01-01

213

Textbook Sales Drop, and University Presses Search for Reasons  

ERIC Educational Resources Information Center

|This article reports that textbook sales are falling at many university presses, a trend that has accelerated in the past couple of months. That's the word from press directors anxious about the decline but unsure what's causing it or how to stop it. Not every press has been affected. Two of the biggest players, Oxford University Press and

Howard, Jennifer

2008-01-01

214

Along Freedom's Double Edge: The Arab Press Under Israeli Occupation.  

ERIC Educational Resources Information Center

|This paper examines the Arab press under Israeli occupation and presents two hypotheses: freedom of the press under occupation serves both Israeli interests and the Arab population, and freedom of the Arab press under occupation is "relative" and "controlled." By allowing freedom of expression, the Israelis achieve several aims: a free press will

Nasser, Munir K.

215

Radiation Conditions in Space and AE9/AP9 Next Generation Radiation Specification Models  

NASA Astrophysics Data System (ADS)

A significant effort is under way to develop the next-generation trapped proton and electron models for satellite design, AP-9 and AE-9, respectively. The primary objectives of the effort are to 1) improve the overall accuracy of the models; 2) provide indicators of the uncertainty in the model due to natural variability and instrument uncertainty; 3) cover a broad energy range including hot plasma, relativistic electrons and highly energetic protons; and 4) provide complete spatial coverage. This paper describes the completed and released version 1.0 and developments for future releases.

O'Brien, Paul; Byers, David; Johnston, William Robert; Ginet, Gregory; Huston, Stuart

2012-07-01

216

Classification of Ap-Stars HR 830 and 21 CVn  

Microsoft Academic Search

Two ambiguously classified Ap stars, HR 830 and 21 CVn, are studied. The observational data are compared with the data for normal stars alpha Del and alpha Lyr. The star HR 830 is classified as Ap of type Si based on the enhanced absorption in the Si lines and photometric variability in UBV. 21 CVn is classified as Ap Si

J. Zverko

1984-01-01

217

DISPLAY OF AMMUNITION PRODUCED ON #8 PRESS (U.S. GOVERNMENT PRESS), ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

DISPLAY OF AMMUNITION PRODUCED ON #8 PRESS (U.S. GOVERNMENT PRESS), SHOWING THE STAGES THROUGH WHICH THE PRODUCTS ARE DRAWN AND FORMED, BEGINNING WITH THE CUPS ON THE LEFT SIDE OF EACH ROW. - American Brass Foundry, 70 Sayre Street, Buffalo, Erie County, NY

218

AUPress: A Comparison of an Open Access University Press with Traditional Presses  

ERIC Educational Resources Information Center

|This study is a comparison of AUPress with three other traditional (non-open access) Canadian university presses. The analysis is based on the rankings that are correlated with book sales on Amazon.com and Amazon.ca. Statistical methods include the sampling of the sales ranking of randomly selected books from each press. The results of one-way

McGreal, Rory; Chen, Nian-Shing

2011-01-01

219

A British Legacy?: The Empire Press Union and Freedom of the Press, 1940-1950  

Microsoft Academic Search

This paper aims to identify and analyse, in the first instance, those key developments that contributed to a resurgence of international debate over freedom of the press in the aftermath of the Second World War. For this purpose, the focus will be on the Empire\\/Commonwealth Press Union and its postwar conferences at London (1946) and Ottawa (1950) respectively. The renewed

Denis Cryle

220

The Dao of human cloning: utopian/dystopian hype in the British press and popular films.  

PubMed

The issue of human cloning has featured in the national science policy agendas in both the United States and the United Kingdom since the announcement in 1997 of Dolly the cloned sheep's birth in Scotland. Such news stories suggesting the imminent cloning of humans have inspired fictional entertainment media over the years, including numerous popular films. Study 1 examines elite British press coverage of human cloning from 1997 to 2004 (n = 857). Study 2 focuses on five human cloning films released between 1978 and 2003. Two sharply divergent discourses emerged from these data. Unqualified hope and habitually hyped claims of future cures permeated the press discourse. In contrast, the films constructed human cloning as an inherently dangerous technology often wielded by hubristic scientists in the tradition of Frankenstein. Both the predominately positive hype in the broadsheet press and the largely negative hype in the films indicate an impoverished and "thin" public debate on the issue of human cloning. PMID:19391375

Jensen, Eric

2008-04-01

221

The duality of LysU, a catalyst for both Ap4A and Ap3A formation.  

PubMed

Heat shock inducible lysyl-tRNA synthetase of Escherichia coli (LysU) is known to be a highly efficient diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) synthase. However, we use an ion-exchange HPLC technique to demonstrate that active LysU mixtures actually have a dual catalytic activity, initially producing Ap4A from ATP, before converting that tetraphosphate to a triphosphate. LysU appears to be an effective diadenosine 5',5'''-P1,P3-triphosphate (Ap3A) synthase. Mechanistic investigations reveal that Ap3A formation requires: (a) that the second step of Ap4A formation is slightly reversible, thereby leading to a modest reappearance of adenylate intermediate; and (b) that phosphate is present to trap the intermediate (either as inorganic phosphate, as added ADP, or as ADP generated in situ from inorganic phosphate). Ap3A forms readily from Ap4A in the presence of such phosphate-based adenylate traps (via a 'reverse-trap' mechanism). LysU is also clearly demonstrated to exist in a phosphorylated state that is more physically robust as a catalyst of Ap4A formation than the nonphosphorylated state. However, phosphorylated LysU shows only marginally improved catalytic efficiency. We note that Ap3A effects have barely been studied in prokaryotic organisms. By contrast, there is a body of literature that describes Ap3A and Ap4A having substantially different functions in eukaryotic cells. Our data suggest that Ap3A and Ap4A biosynthesis could be linked together through a single prokaryotic dual 'synthase' enzyme. Therefore, in our view there is a need for new research into the effects and impact of Ap3A alone and the intracellular [Ap3A]/[Ap4A] ratio on prokaryotic organisms. PMID:16884494

Wright, Michael; Boonyalai, Nonlawat; Tanner, Julian A; Hindley, Alison D; Miller, Andrew D

2006-08-01

222

Variability of the Ap Star HD 9996  

NASA Astrophysics Data System (ADS)

We present here new measurements of the longitudinal magnetic field (Be) in the binary system HD 9996, where the primary companion is an Ap star. Series of 63 Be observations was obtained in years 1994-2011 with the 1-m optical telescope of the Special Astrophysical Observatory (Russia). New magnetic data allowed us to refine the long-term magnetic period of HD 9996 to Pmag=21.8 years. Compilation of archival photometric data showed the existence of long-term variations of HD 9996 in time scale of 22-23 yr consistent with Pmag. We identify Pmag with the precession period of the primary Ap star and summarize search for a short-term rotational period and the rotational line broadening in this star.

Bychkov, V. D.; Bychkova, L. V.; Madej, J.; Shatilov, A. V.

2012-09-01

223

APS control system operating system choice  

SciTech Connect

The purpose of this document is to set down the reasons and decisions regarding what is an important choice for the APS Control System design staff, namely the choice of an operating system for its principle computer resources. Since the choice also may affect cost estimates and the design handbook, there is a further need to document the process. The descriptions and explanations which follow are intended for reading by other APS technical area managers and will contain a minimum of buzz-words, and where buzz-words are used, they will be explained. The author hopes that it will help in understanding the current trends and developments in the volatile and fast-developing computer field.

Knott, M.; Kraimer, M.; Lenkszus, F.

1990-05-01

224

ATP- and Cytosol-dependent Release of Adaptor Proteins from Clathrin-coated Vesicles: A Dual Role for Hsc70  

PubMed Central

Clathrin-coated vesicles (CCV) mediate protein sorting and vesicular trafficking from the plasma membrane and the trans-Golgi network. Before delivery of the vesicle contents to the target organelles, the coat components, clathrin and adaptor protein complexes (APs), must be released. Previous work has established that hsc70/the uncoating ATPase mediates clathrin release in vitro without the release of APs. AP release has not been reconstituted in vitro, and nothing is known about the requirements for this reaction. We report a novel quantitative assay for the ATP- and cytosol- dependent release of APs from CCV. As expected, hsc70 is not sufficient for AP release; however, immunodepletion and reconstitution experiments establish that it is necessary. Interestingly, complete clathrin release is not a prerequisite for AP release, suggesting that hsc70 plays a dual role in recycling the constituents of the clathrin coat. This assay provides a functional basis for identification of the additional cytosolic factor(s) required for AP release.

Hannan, Lisa A.; Newmyer, Sherri L.; Schmid, Sandra L.

1998-01-01

225

APS Storage Ring Monopulse RF BPM Upgrade  

Microsoft Academic Search

The Advanced Photon Source (APS) is a third-generation synchrotron light source in its ninth year of operation. The storage ring monopulse radio frequency (rf) beam position monitor (BPM) was designed to measure single-turn and multi-turn beam positions for operations and machine physics studies. Many of the components used in the original design are obsolete and costly to replace. In this

R. Lill; A. Pietryla; E. Norum; F. Lenkszus

2004-01-01

226

The AN\\/APS6 radar  

Microsoft Academic Search

The AN\\/APS-6 radar was to scan a 1200 coneshaped volume ahead of the aircraft flight path in selected ranges of five, 25 and 65 miles for radar search, with the maximum range extended to 100 miles for radar beacon. When within one-half mile of a selected target, the set could be switched to the gun aim mode for accurate aim-and-fire

F. G. Suffield

1995-01-01

227

Correction magnet power supplies for APS machine  

SciTech Connect

The Advanced Photon Source machine requires a number of correction magnets; five kinds for the storage ring, two for the injector synchrotron, and two for the positron accumulator ring. Three types of bipolar power supply will be used for all the correction magnets. This paper describes the design aspects and considerations for correction magnet power supplies for the APS machine. 3 refs., 3 figs., 1 tab.

Kang, Y.G.

1991-01-01

228

Beryllium window for an APS diagnostics beamline  

SciTech Connect

A beryllium (Be) window for an Advanced Photon Source (APS) diagnostics beamline has been designed and built. The window, which has a double concave axisymmetrical profile with a thickness of 0.5 mm at the center, receives 160 W/mm{sup 2} (7 GeV/100 mA stored beam) from an undulator beam. The window design as well as thermal and thermomechanical analyses, including thermal buckling of the Be window, are presented.

Sheng, I.C.; Yang, B.X.; Sharma, Y.S.

1997-09-01

229

A comparison of peak power in the shoulder press and shoulder throw.  

PubMed

The ability to generate peak power is central for performance in many sports. Currently two distinct resistance training methods are used to develop peak power, the heavy weight/slow velocity and light weight/fast velocity regimes. When using the light weight/fast velocity power training method it was proposed that peak power would be greater in a shoulder throw exercise compared with a normal shoulder press. Nine males performed three lifts in the shoulder press and shoulder throw at 30% and 40% of their one repetition maximum (1RM). These lifts were performed identically, except for the release of the bar in the throw condition. A potentiometer attached to the bar measured displacement and duration of the lifts. The time of bar release in the shoulder throw was determined with a pressure switch. ANOVA was used to examine statistically significant differences where the level of acceptance was set at p < 0.05. Peak power was found to be significantly greater in the shoulder throw at 30% of 1 RM condition [F, (1, 23) = 2.325 p < 0.051 and at 40% of 1 RM [F, (1, 23) = 2.905 p < 0.05] compared to values recorded for the respective shoulder presses. Peak power was also greater in the 30% of 1 RM shoulder throw (510 +/- 103W) than in the 40% of 1 RM shoulder press (471 +/- 96W). Peak power was produced significantly later in the shoulder throw versus the shoulder press. This differing power reflected a greater bar velocity of the shoulder throw at both assigned weights compared with the shoulder press. PMID:12413039

Dalziel, W M; Neal, R J; Watts, M C

2002-09-01

230

Press conference held to announce position statement  

NASA Astrophysics Data System (ADS)

AGU held a press conference on Thursday January 28, at the National Press Club in Washington, D.C., to announce that the AGU Council had adopted a position statement on the subject of climate change and greenhouse gases. AGU members Tamara Ledley, senior scientist with TERC in Cambridge, Mass., Eric Sundquist, research geologist with the U.S. Geological Survey in Woods Hole, Mass., and Tim Killeen, professor of atmospheric, oceanic, and space sciences at the University of Michigan were on hand to discuss the statement and answer questions from members of the press. The three scientists drafted the statement and submitted it for Council approval with Dorothy Hall of the NASA/Goddard Space Flight Center in Greenbelt, Md., Stephen Schwartz of Brookhaven National Lab in Upton, N.Y., and Jack Fellows of the University Corporation for Atmospheric Research in Boulder, Colo. The AGU Council approved the statement in December during the 1998 AGU Fall Meeting.

Folger, Peter

231

The University of California Press Electronic Editions  

NSDL National Science Digital Library

The University of California (UC) presents electronic editions of over 50 academic titles in the fields of African, Middle Eastern, and South Asian studies; Classics; Literature; and European History. The editions offer frames that include the text itself and a detailed table of contents. The texts are available free for online browsing and study, but, of course, cannot be downloaded. Those who want their own copies can purchase them online (click on "View UC Press Catalog Page" under the desired text's title). "UC Press E-Editions is a joint effort between The University of California Press and The University of California Library at Berkeley, and has received substantial support from the Andrew W. Mellon Foundation."

232

Lactate release during the recovery period of pacing-induced angina in assessment of myocardial ischaemia.  

PubMed

Myocardial lactate (L) metabolism was tested in 27 stable angina patients during atrial pacing (AP) and in the recovery period (R) from AP-induced angina pectoris. The recovery period was assessed in order to evaluate the changes in the rate of L release and detect possible relationships with the severity of ischaemic damage. The following variables were assessed: coronary sinus blood flow (CSBF), left ventricular end-diastolic pressure (LVEDP), lactate extraction ratio (L%), lactate extraction or release rate (LR) and myocardial oxygen consumption (MVO2) at the onset of AP (AP1), during angina (AP2), and 30 s, 2 and 4 min (R1, R2 and R3) after AP ceased. At Ap2, negative L% and LR values (-39.37 +/- 43.3, -3.2 +/- 2.9) were found, in spite of a rise in CSBF (+86%, P less than 0.001). Furthermore, LVEDP showed its maximal increase in AP2 (+27%, P less than 0.001). Compared to AP2, L% resulted unchanged in R1, while LR showed a mild decrease (from -3.2 +/- 2.9 to +2.06 +/- 2.93). Lactate production was converted to extraction in R3 only. Since lactate production and release are progressively reduced with increasing severity of ischaemic damage, AP2 coronary sinus lactate release should largely arise from the less damaged areas (i.e. the outer myocardial layers) and the contribution of the more damaged areas (i.e. the inner myocardial layers) should be more limited. After AP ceases, the mild ischaemic areas should recover more rapidly than the severely ischaemic areas, where the damage only declines, leading to a temporary increase in lactate production and release.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:3956525

Cuccurullo, F; Mezzetti, A; Tomassetti, V; Porreca, E; Guglielmi, M D; Pasquale, M; Lapenna, D; Marzio, L; Poggiopollini, G; Lenzi, S

1986-01-01

233

Method for hot pressing beryllium oxide articles  

DOEpatents

The hot pressing of beryllium oxide powder into high density compacts with little or no density gradients is achieved by employing a homogeneous blend of beryllium oxide powder with a lithium oxide sintering agent. The lithium oxide sintering agent is uniformly dispersed throughout the beryllium oxide powder by mixing lithium hydroxide in an aqueous solution with beryllium oxide powder. The lithium hydroxide is converted in situ to lithium carbonate by contacting or flooding the beryllium oxide - lithium hydroxide blend with a stream of carbon dioxide. The lithium carbonate is converted to lithium oxide while remaining fixed to the beryllium oxide particles during the hot pressing step to assure uniform density throughout the compact.

Ballard, A.H.; Godfrey, T.G. Jr.; Mowery, E.H.

1986-10-10

234

The neurosteroid pregnenolone sulfate blocks deficits induced by a competitive NMDA antagonist in active avoidance and lever-press learning tasks in mice  

Microsoft Academic Search

The neurosteroid pregnenolone sulfate (PREG-S) has been shown to modulate positively NMDA receptor activity and to have memory enhancing properties in mice. The present study was designed to evaluate the effects of post-training administration of PREG-S, alone or in combination with D-2-amino-5-phosphonovalerate (D-AP5), a competitive NMDA receptor antagonist, in Y-maze avoidance and appetitively motivated lever-press learning tasks and in a

C. Mathis; E. Vogel; B. Cagniard; F. Criscuolo; A. Ungerer

1996-01-01

235

Proactive AP Selection Method Considering the Radio Interference Environment  

NASA Astrophysics Data System (ADS)

In the near future, wireless local area networks (WLANs) will overlap to provide continuous coverage over a wide area. In such ubiquitous WLANs, a mobile node (MN) moving freely between multiple access points (APs) requires not only permanent access to the Internet but also continuous communication quality during handover. In order to satisfy these requirements, an MN needs to (1) select an AP with better performance and (2) execute a handover seamlessly. To satisfy requirement (2), we proposed a seamless handover method in a previous study. Moreover, in order to achieve (1), the Received Signal Strength Indicator (RSSI) is usually employed to measure wireless link quality in a WLAN system. However, in a real environment, especially if APs are densely situated, it is difficult to always select an AP with better performance based on only the RSSI. This is because the RSSI alone cannot detect the degradation of communication quality due to radio interference. Moreover, it is important that AP selection is completed only on an MN, because we can assume that, in ubiquitous WLANs, various organizations or operators will manage APs. Hence, we cannot modify the APs for AP selection. To overcome these difficulties, in the present paper, we propose and implement a proactive AP selection method considering wireless link condition based on the number of frame retransmissions in addition to the RSSI. In the evaluation, we show that the proposed AP selection method can appropriately select an AP with good wireless link quality, i.e., high RSSI and low radio interference.

Taenaka, Yuzo; Kashihara, Shigeru; Tsukamoto, Kazuya; Yamaguchi, Suguru; Oie, Yuji

236

Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases  

PubMed Central

Background The human genome contains at least 18 genes for Nudix hydrolase enzymes. Many have similar functions to one another. In order to understand their roles in cell physiology, these proteins must be characterised. Results We have characterised two novel human gene products, hAps1, encoded by the NUDT11 gene, and hAps2, encoded by the NUDT10 gene. These cytoplasmic proteins are members of the DIPP subfamily of Nudix hydrolases, and differ from each other by a single amino acid. Both metabolise diadenosine-polyphosphates and, weakly, diphosphoinositol polyphosphates. An apparent polymorphism of hAps1 has also been identified, which leads to the point mutation S39N. This has also been characterised. The favoured nucleotides were diadenosine 5',5"'-pentaphosphate (kcat/Km = 11, 8 and 16 103M-1s-1 respectively for hAps1, hAps1-39N and hAps2) and diadenosine 5',5"'-hexaphosphate (kcat/Km = 13, 14 and 11 103M-1s-1 respectively for hAps1, hAps1-39N and hAps2). Both hAps1 and hAps2 had pH optima of 8.5 and an absolute requirement for divalent cations, with manganese (II) being favoured. Magnesium was not able to activate the enzymes. Therefore, these enzymes could be acutely regulated by manganese fluxes within the cell. Conclusions Recent gene duplication has generated the two Nudix genes, NUDT11 and NUDT10. We have characterised their gene products as the closely related Nudix hydrolases, hAps1 and hAps2. These two gene products complement the activity of previously described members of the DIPP family, and reinforce the concept that Ap5A and Ap6A act as intracellular messengers.

Leslie, Nick R; McLennan, Alexander G; Safrany, Stephen T

2002-01-01

237

Predicting the performance of belt filter presses using the Crown Press for laboratory simulation  

SciTech Connect

Belt filter presses (BFPs) are among the most commonly used devices to dewater wastewater sludge. The concept used by a BFP to achieve dewatered cake solids is relatively simple; however, replicating this performance in the laboratory in order to predict the performance of a BFP with reasonable reliability has proven to be a challenge. The Crown Press is one tool that has been shown to replicate the performance of anaerobically digested sludge on a BFP. This study used the Crown Press to replicate and predict the performance of waste activated sludge (WAS) from the Mauldin Road wastewater treatment plant on BFPs. Several operational variables, including belt speed, belt tension, polymer type, and polymer dose, were changed on the Crown Press to predict how the changes on the BFP would affect performance. Two polymers were chosen to be tested on the BFPs at Mauldin Road based on Crown Press predictions. The first polymer performed the same as the plant`s current polymer in the lab, and the second performed better (achieved higher final cake solids) than the current polymer. These predictions were borne out in the BFP tests, showing that the Crown Press predictions were accurate. The Crown Press predictions were also compared to the predictions made by the capillary suction time (CST) and specific resistance to filtration (SRF) tests. The Crown Press provided more information regarding the affect of polymer type and dose on cake solids than either CST or SRF. The Crown Press was shown to be a viable tool to assess potential changes in BFP performance with WAS when operational variables change.

Graham, T.M.

1999-07-26

238

HOT PRESSING OF POTASSIUM-SODIUM NIOBATES  

Microsoft Academic Search

Compositions in the system KNbO--NaNbO were hotpressed to ; yield ceramics with relative densities greater than 99%. Because these materials ; lack any degree of pyroplastic behavior, temperatures approaching those required ; for air sintering are needed. These hot-pressed specimens exhibit a finer ; microstructure than that obtainable by conventional processing. Enhanced ; piezoelectric coefficients are observed, and in certain

R. E. Jaeger; L. Egerton

1962-01-01

239

The Campus Press: Slouching Toward Respectability  

ERIC Educational Resources Information Center

|In a survey discussion on the state of college newspapers the author observes that the campus press has at last shaken its radical image and returned to respectability: a preprofessional attitude by the staff, interest in investigative reporting, and a concern for the source of the next dollar. (JT)|

Rubin, David

1976-01-01

240

The Suburban Press: A Separate Journalism.  

ERIC Educational Resources Information Center

|This book reports and discusses the findings of a study of suburban newspapers as a third force in the press, different from the other two forces--metropolitan daily newspapers and small-town and weekly newspapers. Chapters explore various aspects of suburban newspapers, including a history of suburbia, publisher attitudes toward the suburban

Lister, Hal

241

THE PERIODICAL PRESS ON POSTAGE STAMPS  

Microsoft Academic Search

The history of journalism is reflected in the philatelic issues of various countries. Stamps of the United States, the Soviet Union, Fmnce, the German Democratic Republic, Sweden, Spain, the nations of South America and the Third World depict mastheads and pages of newspapers and periodicals, portraits of their publishers and editors, press buildings and associations, schools of journalism, newsboys. Authors

Leona Rostenberg

1978-01-01

242

Automating friction press working for ceramics manufacture  

Microsoft Academic Search

The carriage 1 moving up to the support 10 rotates it and frees the pushing device 2 which is lowered, and together with this lowers the bottom knives (plungers). The press powder is filled. Simultaneously the contacts 3 of the electromagnetic clutch 7 are closed, and the carriage under the action of the weight is returned to the original position;

I. S. Gulak

1966-01-01

243

[Report from the Student Press Law Center.  

ERIC Educational Resources Information Center

|The Student Press Law Center serves as a national clearinghouse to collect, analyze, and distribute information on the First Amendment rights of student journalists and journalism teachers and on violations of these rights in high schools and colleges. This report details information concerning current censorship incidents: the investigation by

Student Press Law Center, Washington, DC.

244

Research Review: The Specialized Business Press.  

ERIC Educational Resources Information Center

|Reviews scholarly research (from journalism, communication, business, and the humanities) on the specialized business press. Notes the lack of theory building and ties across disciplines, and anticipates that new advances in CD-ROM technology may increase research into the field as well as strengthen ties across disciplines. (SR)|

Endres, Kathleen L.

1994-01-01

245

Neo-Lysenkoism, IQ, and the Press.  

ERIC Educational Resources Information Center

In "The Mismeasure of Man," a history of efforts to measure intelligence, Stephen Jay Gould is highly selective in his account, and tests for scientific truth by the standards of his own social and political convictions. Specifically, to combat racist approaches to theories of intelligence, Gould presses for equal and opposite bias. (Author/GC)

Davis, Bernard D.

1983-01-01

246

Modeling of the Hot Isostatic Pressing Process.  

National Technical Information Service (NTIS)

This report describes the first year of progress of a two year investigation to develop a modeling strategy to predict the final shape of components manufactured by the Hot Isostatic Pressing (HIP) process. When a powder metal is subjected to the high pre...

B. N. Cassenti K. J. Cheverton

1979-01-01

247

Press and the Persian Gulf War.  

National Technical Information Service (NTIS)

The subject of press pools and escorts has been frequently written about, and the commentaries have been infrequently kind. Indeed, two negative myths have grown popular in the aftermath of the Gulf War, and they need to be debunked. The first is that the...

P. Williams

1991-01-01

248

Three Years after "Hazelwood": Students Press On.  

ERIC Educational Resources Information Center

|The U.S. Supreme Court's "Hazelwood School District v. Kuhlmeier" decision (1988) gave principals new authority to monitor the content of student publications. Since then, the "Student Press Law Center Report," a clearinghouse for aggrieved publication advisers and student editors, has reported censorship problems that never existed before.

Goldman, Jay P.

1991-01-01

249

Belief in Freedom of Speech and Press  

ERIC Educational Resources Information Center

|Presents data regarding belief in freedom of speech and press collected in early 1970 in face to face interviews with 2,486 respondents in a national probability sample of adults in order to test several hypotheses derived from previous empirical research, noting that the pattern of differential distribution of such belief appears to be quite

Wilson, W. Cody

1975-01-01

250

Freedom of the Press: Foundations and Attitudes.  

ERIC Educational Resources Information Center

|This study reports the results of a national survey of the attitudes of five demographic groups toward freedom of the press. The groups are newsmen, state legislators, high school teachers, high school students, and the general public. The survey is broken into two parts, the first dealing with general principles (e.g., support for a law against

Gibson, Martin Leroy, Jr.

251

Fair Trials and Free Press. Student Forum.  

ERIC Educational Resources Information Center

|Outlines a role play that highlights the potential conflict between freedom of the press and the rights of defendants and victims. Students assume the roles of representative characters (police chief, newspaper editor) in a small town where a sensational murder has occurred. They also conduct a class discussion. (MJP)|

Mertz, Gayle

1997-01-01

252

A Journalist's Guide to the Free Press.  

ERIC Educational Resources Information Center

|Summarizes the content of the federal constitution and various state constitutions regarding freedom of the press. Examines certain borderline issues, including actions and expressions, pornography, defamation, libel, and copyrighted material. States that regulation of unprotected material must be reasonable, specific, and clear. Discusses what

Ingelhart, Louis

1996-01-01

253

When International Press Rights "Are" the News  

ERIC Educational Resources Information Center

|In many countries, reporters and editors face criminal prosecution, censorship, self-censorship, exile, tax audits, loss of broadcast and publication licenses, loss of jobs, assault, and even assassination based on how they practice their profession. Press rights and human rights advocacy groups try to draw media and official attention to those

Freedman, Eric

2006-01-01

254

Law of the Student Press. Second Edition.  

ERIC Educational Resources Information Center

|Noting dramatic changes in First Amendment protections for high school students and new legal issues facing college newspaper editors, this book describes in detail the legal rights and responsibilities of both the high school and college press. While the book is extensively footnoted, it intentionally avoids "legal-ese" and "brings law to life"

Student Press Law Center, Washington, DC.

255

Should the Press Ever Be Limited?  

ERIC Educational Resources Information Center

|Activities dealing with First Amendment issues involve secondary students in exploring freedom of the press and speech in general and as they apply in the schools and in developing a personal position regarding the appropriate balance between the public's right to know and the need for national security. (RM)|

Greenawald, Dale

1985-01-01

256

Public Discourse, Expert Knowledge, and the Press  

Microsoft Academic Search

This Essay identifies and elaborates two complications raised by Robert Posts Democracy, Expertise, and Academic Freedom, and in doing so attempts to show how Posts theory can account for constitutional protection of the press. The first complication is a potential circularity arising from the relationships between the concepts of democratic legitimation, public discourse, and protected social practices. Democratic legitimation predicates

Joseph Blocher

2012-01-01

257

ULTRASONIC HOT PRESSING OF METALS AND CERAMICS  

Microsoft Academic Search

The feasibility of ultrasonic hot pressing was demonstrated on silver, ; calcium fluoride, and aluminum oxide powders. A hermetically-sealable, force-; insensitive acoustic mounting system was used to penetrate into the high-pressure ; (up to 5000 psi) and high-temperature (up to 2550 deg F) controlled atmosphere ; environment. The density of silver powder compacts was increased as much as 1.6 ;

W. B. Tarpley; H. Kartluke

1961-01-01

258

Digital assembly system design for printing press  

Microsoft Academic Search

Through analyzing deficiencies of the traditional assembly process design, and applying Design For Assembly (DFA) and digital assembly technology, the functional structure of a three-dimensional assembly system is proposed and studied. Based on the secondary development technology of SolidWorks, the virtual assembly system for a typical printing press is designed. Applications of key technologies are explored, which include the capture

Gao Bo; Zhang XiaoGui

2011-01-01

259

Hot-pressed polycrystalline yttrium iron garnet  

Microsoft Academic Search

A simple hot-pressing system is described which enables small volumes of polycrystalline yttrium iron garnet to be routinely produced. The products have high density, very low second phase content and a controlled grain size. Their magnetic properties compare very favourably with similar polycrystalline material produced by conventional sintering. Sample porosity may be varied in a controlled manner by simple changes

G. A. Naziripour; A. O. Tooke; K. J. Standley; B. E. Storey

1985-01-01

260

Design and assessment of the new APS dialyzer (APS-SA series)  

Microsoft Academic Search

Dialyzer performance seems to greatly depend on the hollow-fiber membrane performance, the morphology of the hollow-fiber\\u000a membrane bundles (e.g., wave-shaped hollow-fiber membrane bundles), and the design of the dialyzer housing. Consequently,\\u000a we developed the APS dialyzer APS-SA series, equipped with wave-shaped hollow-fiber membrane bundles as an optimal three-dimensional\\u000a morphology along with new housings, to realize enhanced dialysis performance. Incorporation of

Makoto Fukuda; Miwa Miyazaki; Satoshi Uezumi; Makoto Yoshida

2006-01-01

261

Kiln for hot-pressing compacts in a continuous manner  

DOEpatents

The invention is directed to a hot pressing furnace or kiln which is capable of preheating, hot pressing, and cooling a plurality of articles in a sequential and continuous manner. The hot pressing furnace of the present invention comprises an elongated, horizontally disposed furnace capable of holding a plurality of displaceable pusher plates each supporting a die body loaded with refractory or ceramic material to be hot pressed. Each of these plates and the die body supported thereby is sequentially pushed through the preheating zone, a temperature stabilizing and a hot pressing zone, and a cooling zone so as to provide a continuous hot-pressing operation of a plurality of articles.

Reynolds, C.D Jr.

1983-08-08

262

Kiln for hot-pressing compacts in a continuous manner  

DOEpatents

The present invention is directed to a hot pressing furnace or kiln which is capable of preheating, hot pressing, and cooling a plurality of articles in a sequential and continuous manner. The hot pressing furnace of the present invention comprises an elongated, horizontally disposed furnace capable of holding a plurality of displaceable pusher plates each supporting a die body loaded with refractory or ceramic material to be hot pressed. Each of these plates and the die body supported thereby is sequentially pushed through the preheating zone, a temperature stabilizing and a hot pressing zone, and a cooling zone so as to provide a continuous hot-pressing operation of a plurality of articles.

Reynolds, Jr., Carl D. (Clinton, TN)

1985-01-01

263

Pig's blood in cigarette filters: how a single news release highlighted tobacco industry concealment of cigarette ingredients.  

PubMed

The tobacco industry is not obligated to disclose ingredients and additives used in manufactured tobacco production. This paper describes global reaction to a press release highlighting evidence that porcine haemoglobin ("pig's blood") was sometimes used in cigarette manufacturing while never being disclosed to smokers. The case study illustrates the power of press releases to ignite major interest in tobacco control issues. PMID:21172854

Mackenzie, Ross; Chapman, Simon

2010-12-15

264

Commerical Laundry, Drycleaning and Pressing Machine Manufacturing: 1997 Economic Census Manufacturing Industry Series  

NSDL National Science Digital Library

The US Department of Commerce Census Bureau has released the few in a series of several hundred reports on individual industries in the manufacturing sector from the 1997 Economic Census. The 1997 Economic Census series on the Commercial Laundry, Drycleaning, and Pressing Machine Manufacturing does not include state comparisons but reports on total capital expenditures in Illinois as well as the US as a whole.

1999-01-01

265

Ozone mitigation tests at the APS  

SciTech Connect

Ozone is generated in the APS experimental stations whenever the x-ray beam has a chance to interact with air. Ozone concentrations in an experimental station have to be below a certain defined limit (current OSHA regulations specify 0.08 ppm as the maximum limit) before an experimenter can reenter the hutch. This limit is said to be currently under study for a downward adjustment. One method of depleting the ozone generated in an experimental station is mitigation through either adsorption or direct destruction. In recent tests, both methods were tried using commercially available units. Test results and some analytical predictions are presented.

Kuzay, T.M.; Collins, J.T.; Pisharody, M.; Job, P.K.; Wang Zhibi

1996-09-01

266

The APS machine protection system (MPS)  

SciTech Connect

The machine protection system (MPS) that protects the APS storage ring vacuum chamber from x-ray beams, is active. There are over 650 sensors monitored and networked through the MPS system. About the same number of other process variables are monitored by the much slower EPICS control system, which also has an input to the rf abort chain. The MPS network is still growing with the beam position limits detection system coming on-line. The network configuration, along with a limited description of individual subsystems, is presented.

Fuja, R.; Berg, B.; Arnold, N. [and others

1996-08-01

267

Review of the APS SR RF systems.  

SciTech Connect

The Advanced Photon Source (APS) is a 7-GeV full energy storage ring (SR) for generating synchrotron radiation with an injector. The storage ring cavities consist of four groups of four single cells powered by up to four 1-MW klystrons for up to 300-mA operation. A review of the operation of the rf system as well as rf-related beam dynamics is presented. This review includes rf power distribution, low-level feedback, control law, beam loading, beam instabilities, higher-order modes, and beam-induced multipactoring.

Song, J.J.; Cours, A.; Grelick, A.; Harkay, K.; Horan, D.; Kang, Y.W.; Kustom, R.L.; Nassiri, A.; Pile, G.; Smith, T.L.

1998-03-31

268

Scholastic Journalism Week, February 23-29, 1992. Celebrating 200 Years, Freedom of the Press, Bill of Rights.  

ERIC Educational Resources Information Center

|Designed to raise community consciousness regarding the benefits of scholastic journalism, this collection of material offers suggestions for celebrating Scholastic Journalism Week. The collection provides: brief suggestions for 11 school activities; brief descriptions of 8 classroom activities; a sample press release for scholastic journalism

Journalism Education Association.

269

Regulation of carcinoembryonic antigen release from colorectal cancer cells  

Microsoft Academic Search

Clinical and experimental evidence suggest that circulating carcinoembryonic antigen (CEA) released from tumor cells has an\\u000a instrumental role in colorectal cancer-liver metastasis. However, the precise mechanism of the regulation of the CEA release\\u000a from cancer cells is not known. We investigated if the rate of CEA and another GPI-anchored protein, alkaline phosphatase\\u000a (AP) release is correlated with cellular glycosylphosphatidylinositol-specific phospholipase

Abbas Pakdel; Fakhraddin Naghibalhossaini; Pooneh Mokarram; Mansooreh Jaberipour; Ahmad Hosseini

270

Transcription factor AP-2alpha triggers apoptosis in cardiac myocytes.  

PubMed

Idiopathic-dilated cardiomyopathy (IDC) is a common primary myocardial disease of unknown etiology associated with apoptosis, cardiac dilatation, progressive heart failure and increased mortality. An elevation of the transcription factor activator protein 2alpha (AP-2alpha) is involved in vertebrate embryonic development and oncogenesis. Here, we show that AP-2alpha protein is expressed in the human heart and increased in human failing myocardium with IDC. Adenovirus-mediated overexpression of human AP-2alpha triggered apoptosis and increased mRNA levels of Bcl-2 family members Bax and Bcl-x in rat cardiomyocytes. Immunohistological analysis of human myocardium revealed an increased percentage of AP-2alpha-positive nuclei in IDC and, interestingly, a colocalization of AP-2alpha-positive but not -negative cells with a caspase-cleaved fragment of poly(ADP-ribose)polymerase. We suggest AP-2alpha as a novel cardiac regulator implicated in the activation of apoptosis in IDC. PMID:14752511

Mller, F U; Loser, K; Kleideiter, U; Neumann, J; von Wallbrunn, C; Dobner, T; Scheld, H-H; Bantel, H; Engels, I H; Schulze-Osthoff, K; Schmitz, W

2004-05-01

271

9. INTERIOR VIEW OF EYE PRESS AREA; TO LEFT IS ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. INTERIOR VIEW OF EYE PRESS AREA; TO LEFT IS A TWO-BAY SLOTTED TYPE FURNACE, TO CENTER IS EYE PRESS, TO RIGHT IS CURCULAR SAW - Warwood Tool Company, Foot of Nineteenth Street, Wheeling, Ohio County, WV

272

Press Molds for Powder Metallurgy. Design and Construction.  

National Technical Information Service (NTIS)

The technological principles and classification of the methods of formation of cermet articles are presented, the principles of constructing press molds for cold and hot pressing of articles from metallic powders are stated, and also the repressing and ca...

E. L. Pechentkovskii G. G. Serdyuk I. D. Radomyselskii

1971-01-01

273

The APS control system network upgrade.  

SciTech Connect

When it was installed,the Advanced Photon Source (APS) control system network was at the state-of-the-art. Different aspects of the system have been reported at previous meetings [1,2]. As loads on the controls network have increased due to newer and faster workstations and front-end computers, we have found performance of the system declining and have implemented an upgraded network. There have been dramatic advances in networking hardware in the last several years. The upgraded APS controls network replaces the original FDDI backbone and shared Ethernet hubs with redundant gigabit uplinks and fully switched 10/100 Ethernet switches with backplane fabrics in excess of 20 Gbits/s (Gbps). The central collapsed backbone FDDI concentrator has been replaced with a Gigabit Ethernet switch with greater than 30 Gbps backplane fabric. Full redundancy of the system has been maintained. This paper will discuss this upgrade and include performance data and performance comparisons with the original network.

Sidorowicz, K. v.; Leibfritz, D.; McDowell, W. P.

1999-10-22

274

APS Insertion Devices: Recent Developments and Results.  

PubMed

The Advanced Photon Source (APS) now has a total of 23 insertion devices (IDs). Over two-thirds of them are installed on the storage ring. The installed devices include 18, 27 and 55 mm-period undulators; an 85 mm-period wiggler; a 16 cm-period elliptical multipole wiggler; and many 33 mm-period undulators. Most of the IDs occupy storage-ring straight sections equipped with 8 mm vertical-aperture vacuum chambers. All of the IDs were measured magnetically at the APS and, in most cases, underwent a final magnetic tuning in order to minimize variation in the various integrals of the field through the ID over the full gap range. Special shimming techniques to correct magnetic field parameters in appropriate gap-dependent ways were developed and applied. Measurements of the closed-orbit distortion as a function of the ID gap variation have been completed, and results are in a good agreement with magnetic measurements. Spectral diagnostics of the ID radiation, including measurements of the absolute spectral flux, brilliance and polarization, show excellent agreement between calculated and measured results. Studies of the sensitivity of IDs to radiation exposure and measurements of the dose rate received by the IDs are in progress. PMID:15263477

Gluskin, E

1998-05-01

275

Answers and Questions from the KvAP Structures  

Microsoft Academic Search

The recent landmark structures of KvAP, a voltage-gated potassium (Kv) channel, provide the first high-resolution experimental structural models of this class of proteins. Previous extensive studies of Kv channels provide a means to evaluate and interpret the KvAP structures. In this minireview, we survey different experimental approaches to Kv channels and map these findings to KvAP, showing that the relationship

Bruce E Cohen; Michael Grabe; Lily Yeh Jan

2003-01-01

276

Tank 241-AP-108 grab sampling and analysis plan  

SciTech Connect

This Sampling and Analysis Plan (SAP) will identify characterization objectives for sample collection, laboratory analytical evaluation, and reporting requirements for tank 241-AP-108 (AP 108). It is written in accordance with the Tank 241-AP-108 Tank Characterization Plan, the Tank Safety Screening Data Quality Objective, the 242-A Evaporator Liquid Effluent Retention Facility Data Quality Objectives, and the Data Quality Objectives for Tank Farms Waste Compatibility Program.

Baldwin, J.H., Fluor Daniel Hanford

1997-02-07

277

The AP3 complex: a coat of many colours  

Microsoft Academic Search

A new adaptor protein complex, termed AP-3, has recently been identified in mammalian cells, and genetic studies in yeast have revealed a functional role for the AP-3 complex in cargo-selective transport via a new alternative trafficking pathway from the Golgi to the vacuole\\/lysosome. Here, the authors review what is currently known about the AP-3 complex and discuss recent insight into

Greg Odorizzi; Christopher R Cowles; Scott D Emr

1998-01-01

278

Tank 241AP108 grab sampling and analysis plan  

Microsoft Academic Search

This Sampling and Analysis Plan (SAP) will identify characterization objectives for sample collection, laboratory analytical evaluation, and reporting requirements for tank 241-AP-108 (AP 108). It is written in accordance with the Tank 241-AP-108 Tank Characterization Plan, the Tank Safety Screening Data Quality Objective, the 242-A Evaporator Liquid Effluent Retention Facility Data Quality Objectives, and the Data Quality Objectives for Tank

Fluor Daniel Hanford

1997-01-01

279

Roles of AP2 in Clathrin-Mediated Endocytosis  

Microsoft Academic Search

BackgroundThe notion that AP-2 clathrin adaptor is an essential component of an endocytic clathrin coat appears to conflict with recent observations that substantial AP-2 depletion, using RNA interference with synthesis of AP-2 subunits, fails to block uptake of certain ligands known to internalize through a clathrin-based pathway.Methodology\\/Principal FindingsWe report here the use of in vivo imaging data obtained by spinning-disk

Emmanuel Boucrot; Saveez Saffarian; Rongying Zhang; Tomas Kirchhausen; Richard Steinhardt

2010-01-01

280

Influence of cell concentration, temperature, and press performance on flow characteristics and disintegration in the freeze-pressing of Saccharomyces cerevisiae with the X-press.  

PubMed

The pressure required for initiation of flow when freeze-pressing with the X-press is related to the phase boundaries of water, particularly those between ice I and liquid even at temperatures around -25 degrees C and lower. Widening the orifice of the pressure chamber to diameters larger than 2.5 mm leads to lower pressures and less extensive cell disintegration. Pressing Saccharomyces cerevisiae slowly with the aid of a manual hydraulic jack at -25 degrees C produces a disintegration of 60-75% irrespective of cell concentration. Pressing at -35 degrees C shows no clear differences. Pressing more rapidly with the aid of a motor-driven hydraulic press produces a similar extent of disruption of diluted cell suspensions (5.4 mg/g) as slow pressing. However, freeze-pressing a paste of baker's yeast (270 mg/g) increases the degree of disintegration. Under these conditions the disintegration is further enhanced by a lower temperature, -35 degrees C, and by a high velocity of flow through the orifice, such that more than 95% of the S. cerevisiae is disrupted by one pressing at less than 2 X 10(8) Pa. Mechanisms for flow through the X-press are suggested and discussed in relation to the phase diagram of water. PMID:773453

Magnusson, K E; Edebo, L

1976-06-01

281

Hot-pressed neodymium-iron-boron magnets  

Microsoft Academic Search

A new method is described which produces fully dense, well-aligned Nd-Fe-B magnets from rapidly quenched ribbons. Full density is achieved by hot pressing at ?15 kpsi in argon at 700 C. A second hot press in a larger die cavity to allow deformation transverse to the press direction (die upsetting) introduces a preferred magnetization direction parallel to the press direction.

R. W. Lee

1985-01-01

282

Hot-pressed neodymium-iron-boron magnets  

Microsoft Academic Search

A new method is described which produces fully dense, well-aligned Nd-Fe-B magnets from rapidly quenched ribbons. Full density is achieved by hot pressing at approximately 15 kpsi in argon at 700 C. A second hot press in a larger die cavity to allow deformation transverse to the press direction (die upsetting) introduces a preferred magnetization direction parallel to the press

R. W. Lee

1985-01-01

283

Reducing VOC Press Emission from OSB Manufacturing  

SciTech Connect

Current regulations require industry to meet air emission standards with regard to particulates, volatile organic compounds (VOCs), hazardous air pollutants (HAPs) and other gases. One of many industries that will be affected by the new regulations is the wood composites industry. This industry generates VOCs, HAPs, and particulates mainly during the drying and pressing of wood. Current air treatment technologies for the industry are expensive to install and operate. As regulations become more stringent, treatment technologies will need to become more efficient and cost effective. The overall objective of this study is to evaluate the use of process conditions and chemical additives to reduce VOC/HAPs in air emitted from presses and dryers during the production of oriented strand board.

Dr. Gary D. McGinnis; Laura S. WIlliams; Amy E. Monte; Jagdish Rughani: Brett A. Niemi; Thomas M. Flicker

2001-12-31

284

Method for hot pressing beryllium oxide articles  

DOEpatents

The hot pressing of beryllium oxide powder into high density compacts with little or no density gradients is achieved by employing a homogeneous blend of beryllium oxide powder with a lithium oxide sintering agent. The lithium oxide sintering agent is uniformly dispersed throughout the beryllium oxide powder by mixing lithium hydroxide in an aqueous solution with beryllium oxide powder. The lithium hydroxide is converted in situ to lithium carbonate by contacting or flooding the beryllium oxide-lithium hydroxide blend with a stream of carbon dioxide. The lithium carbonate is converted to lithium oxide while remaining fixed to the beryllium oxide particles during the hot pressing step to assure uniform density throughout the compact.

Ballard, Ambrose H. (Oak Ridge, TN); Godfrey, Jr., Thomas G. (Oak Ridge, TN); Mowery, Erb H. (Clinton, TN)

1988-01-01

285

Iodine Volatility and pH Control in the AP-600 Reactor  

SciTech Connect

Two design-basis accidents for the AP-600 reactor are formulated and evaluate~ in which significant bypass of the principal pH control system occurs. Some iodine released from the reactor primary system is retained in the Incontainment Refaeling Water Storage Tank (IRWST) water, never entering the containment where trisodium phosphate produces a high pH. Some of this iodine is volatilized and is transported into the reactor containment airspace. in the worst case, a small fraction is released to the environment at design-basis leak rate, yielding a total cumulative iodine release at 30 days of 0.0352 mol (0.023% of core iodine inventory) due to the iodine volatilization bypassing the pH control system. No fission product removal in the containment atmosphere (i.e., natural deposition sprays) is considered.

Beahm, E.C.; Weber, C.F.

1998-10-01

286

Cytotoxic Evaluation of 3-Aminopyridine-2-Carboxaldehyde Thiosemicarbazone, 3-AP, in Peripheral Blood Lymphocytes of Patients with Refractory Solid Tumors using Electron Paramagnetic Resonance.  

PubMed

PURPOSE: 3-AP (3-aminopyridine-2-carboxaldehyde thiosemicarbazone, 3-AP) is a metal chelator that potently inhibits the enzyme ribonucleotide reductase, RR, which plays a key role in cell division and tumor progression. A sub-unit of RR has a non-heme iron and a tyrosine free radical, which are required for the enzymatic reduction of ribonucleotides to deoxyribonucleotides. The objective of the study was to determine whether 3-AP affects its targeted action by measuring EPR signals formed either directly or indirectly from low molecular weight ferric-3-AP chelates. METHODS: Peripheral blood lymphocytes were collected from patients with refractory solid tumors at baseline and at 2, 4.5 and 22 hours after 3-AP administration. EPR spectra were used to identify signals from high-spin Fe-transferrin, high-spin heme and low-spin iron or copper ions. RESULTS: An increase in Fe-transferrin signal was observed, suggesting blockage of Fe uptake. It is hypothesized that formation of reactive oxygen species by FeT(2) or CuT damage transferrin or the transferrin receptor. An increase in heme signal was also observed, which is a probable source of cytochrome c release from the mitochondria and potential apoptosis. In addition, increased levels of Fe and Cu were identified. CONCLUSION: These results, which were consistent with our earlier study validating 3-AP-mediated signals by EPR, provide valuable insights into the in vivo mechanism of action of 3-AP. PMID:21373381

Kolesar, Jill M; Sachidanandam, Kamakshi; Schelman, William R; Eickhoff, Jens; Holen, Kyle D; Traynor, Anne M; Alberti, Dona B; Thomas, James P; Chitambar, Christopher R; Wilding, George; Antholine, William E

2011-01-01

287

Unskilled Finger Key Pressing and Brain Coherence  

Microsoft Academic Search

To press a computer key by an unskilled finger is sometimes an adaptive way to successfully access computer for the persons\\u000a with quadriplegia. The efficiency of the unskilled site during the learning process should be addressed. Currently, we also\\u000a want to know how the brain works in this unskilled situation during the learning process. Therefore, this combined motor behavioral\\u000a and

Ling-Fu Meng; Chiu-ping Lu; Ching-horng Chen

2006-01-01

288

Magellan Press Conference (2 of 2)  

NASA Astrophysics Data System (ADS)

Live footage shows the speakers participating in the Magellan Press Conference question and answer session. Speakers include Huntress, Spear, Ledbetter, Johnson, McCarthy, and Saunders. The speakers are shown answering questions from various NASA Centers, and participating audience members from many different industries. They discuss the start and stop date for the mapping. Also shown are animation and radar images of Venus and Artemis. This is tape 2 of 2; tape 1 has a report number NONP-NASA-VT-2000036552.

1991-10-01

289

AP endonuclease independent repair of abasic sites in Schizosaccharomyces pombe  

PubMed Central

Abasic (AP) sites are formed spontaneously and are inevitably intermediates during base excision repair of DNA base damages. AP sites are both mutagenic and cytotoxic and key enzymes for their removal are AP endonucleases. However, AP endonuclease independent repair initiated by DNA glycosylases performing ?,?-elimination cleavage of the AP sites has been described in mammalian cells. Here, we describe another AP endonuclease independent repair pathway for removal of AP sites in Schizosaccharomyces pombe that is initiated by a bifunctional DNA glycosylase, Nth1 and followed by cleavage of the baseless sugar residue by tyrosyl phosphodiesterase Tdp1. We propose that repair is completed by the action of a polynucleotide kinase, a DNA polymerase and finally a DNA ligase to seal the gap. A fission yeast double mutant of the major AP endonuclease Apn2 and Tdp1 shows synergistic increase in MMS sensitivity, substantiating that Apn2 and Tdp1 process the same substrate. These results add new knowledge to the complex cellular response to AP sites, which could be exploited in chemotherapy where synthetic lethality is a key strategy of treatment.

Nilsen, Line; Forstr?m, Rune J.; Bj?ras, Magnar; Alseth, Ingrun

2012-01-01

290

Synaptic vesicle recycling at CNS synapses without AP-2  

PubMed Central

Synaptic vesicles (SVs) are composed of ~10 types of transmembrane proteins that must be recycled following exocytosis of neurotransmitter. The mechanisms for resorting these proteins into synaptic vesicles once incorporated into the plasma membrane following exocytosis are poorly understood. The adaptor complex AP-2 is the major clathrin-associated adaptor for cargo recognition at the plasma membrane. Here we have investigated its role in synaptic vesicle endocytosis. shRNA-mediated knockdown of the AP-2 complex results in a ~96% reduction of this protein complex in primary neurons. We used simultaneous expression of shRNA and pHluorin-tagged vesicle components to show that the absence of AP-2 significantly slows, but does not prevent the endocytosis of 4 of the major synaptic vesicle transmembrane proteins. We show that in the absence of AP-2, the AP-1 adaptor complex appears to functionally substitute for AP-2, but results in complex internalization kinetics that are now sensitive to the ARF-GEF inhibitor Brefeldin-A. Simultaneous removal of both AP-2 and AP-1 prevents this compensatory substitution and results in slowed but functional endocytosis. These results demonstrate that in the absence of AP-2 SV proteins still become endocytosed and synaptic vesicle recycling remains operational.

Kim, Sung Hyun; Ryan, Timothy. A.

2009-01-01

291

Tank 241-AP-102 Vapor Sampling and Analysis Plan  

SciTech Connect

This tank sampling and analysis plan (SAP) identifies characterization objectives pertaining to sample collection, laboratory analytical evaluation, and reporting requirements for vapor samples from the head space of tank 241-AP-102. Sampling will be performed in accordance with ''Data Quality Objectives for Regulatory Requirements for Hazardous and Radioactive Air Emissions Sampling and Analysis'' (Air DQO) (Mulkey 1999). The sample results will verify if current air emission estimates used in the permit application are correct and provide information for future air permit applications. Samples taken in support of the DQO will consist of SUMMA{trademark} canisters, triple sorbent traps (TSTs), sorbent tube trains (STTs), polyurethane foam (PUF) samples, and particulate filters. Particulate filter samples and tritium traps will be taken for radiation screening to allow the release of the samples for analysis and for analysis of specific radionuclides. The following sections provide the general methodology and procedures to be used in the preparation, retrieval, transport, analysis, and reporting of results from the vapor samples.

TEMPLETON, A.M.

2001-01-24

292

The Tasmanian Conservation Movement and the Press: Research Note1  

Microsoft Academic Search

The key focus of this note is the changing pattern of such coverage in the Tasmanian press over the period of nearly two decades and four environmental debates. The analysis provides an illustration of the dynamics of press coverage and changing relationship between the environment movement and the daily press. It is suggested that a symbiotic relationship has developed between

Kim Sylow

1994-01-01

293

The Historical Importance of Jury to Press Freedom.  

ERIC Educational Resources Information Center

Staggered by some recent libel verdicts, many journalists are neglecting lessons about press freedom learned at great cost during the seventeenth and eighteenth centuries. Journalists then learned that state power over the press, residing in the hands of either censors or judges, leads to a decrease in press freedom. In 1986, though, many media

Olasky, Marvin N.

294

Living Dangerously--Changing Press Law in India.  

ERIC Educational Resources Information Center

|An examination of the changes in press laws after India gained its independence in 1947 shows how a free press is shaped mostly by the structure and evolution of the democratic society that it is intended to serve. The most salient features that have characterized the Indian press, from the early nineteenth century to the present day, are

Ryan, Timothy

295

THE RISE AND POSSIBLE FALL OF THE SWEDISH PARTY PRESS  

Microsoft Academic Search

In contrast to many other western countries, Sweden still has a party press system. The historical background of the Swedish party press, its present situation and its possible future is outlined in this article. The party press is an integral part of the Swedish political structure. It worked well for the better part of a century, but today it is

STIG HADENIUS

1983-01-01

296

Graphic Arts: The Press and Finishing Processes. Third Edition.  

ERIC Educational Resources Information Center

This document contains teacher and student materials for a course in graphic arts concentrating on printing presses and the finishing process for publications. Seven units of instruction cover the following topics: (1) offset press systems; (2) offset inks and dampening chemistry; (3) offset press operating procedures; (4) preventive maintenance

Crummett, Dan

297

Application of Electronic Motor Drives to Printing Presses  

Microsoft Academic Search

At least 50 years have passed since rotary web printing presses reached, essentially, their present form. As innumerable refinements gradually improved the quality of the product and increased speed of the presses, corresponding advances were made in electric motor drives. Press drives, as a result, are highly refined, specialized equipments designed to do a definite job. Application problems will be

J. A. Johnson; E. M. Stacey

1950-01-01

298

Lesquerella Press Cake as an Organic Fertilizer for Greenhouse Tomatoes  

Technology Transfer Automated Retrieval System (TEKTRAN)

Lesquerella press cake is a co-product generated during the processing of the new oilseed crop lesquerella [Lesquerella fendleri (A. Gray) S. Wats.]. Developing commercial uses for the press cake would increase the profitability of growing lesquerella. The press cake contains levels of nutrients w...

299

The shearing characteristics associated with equal-channel angular pressing  

Microsoft Academic Search

Equal-channel angular (ECA) pressing is a processing method for introducing an ultra-fine grain size into a material. In practice, it is a procedure that may be used to achieve high total strains by subjecting a sample to repetitive pressings. There is experimental evidence showing that the nature of the microstructural evolution in ECA pressing depends upon whether the sample is

Minoru Furukawa; Yoshinori Iwahashi; Zenji Horita; Minoru Nemoto; Terence G. Langdon

1998-01-01

300

A contribution to the empirics of press freedom and corruption  

Microsoft Academic Search

We test the relationship between aggregate press freedom and corruption performing a modified extreme bounds analysis. We also test the relation among different forms of restrictions to press freedom using previously unexplored disaggregated data. Our results support the theoretical view that restrictions to press freedom leads to higher corruption. Furthermore, we obtain that both political and economic influences on the

Sebastian Freille; M. Emranul Haque; Richard Kneller

2007-01-01

301

Searching for a Free Press in Indian Country.  

ERIC Educational Resources Information Center

|Describes the tribally controlled media's efforts to provide a form of checks and balances against the tribal council on behalf of the tribal community. Examines the issue of freedom of the tribal press, suggesting that tribal council's control of press's operating funds may limit press freedom. (MAB)|

Benton, Sherrole

1994-01-01

302

Freedom of the Press in an International Perspective. Teaching Strategy.  

ERIC Educational Resources Information Center

|Presents a lesson plan that compares freedom of the press in the United States and other countries. Reveals the extent to which the First Amendment protects press freedom from abuses found in other countries. Includes a world map illustrating areas enjoying freedom of the press, and related statistical tables. (MJP)|

Miller, Barbara

1997-01-01

303

Project W-211, initial tank retrieval systems, description of operations for 241-AP-102 and 241-AP-104  

SciTech Connect

The primary purpose of the Initial Tank Retrieval Systems (ITRS) is to provide systems for retrieval of radioactive wastes stored in underground double-shell tanks (DSTS) for transfer to alternate storage, evaporation, pretreatment or treatment, while concurrently reducing risks associated with safety watch list and other DSTs. This Description of Operations (DOO) defines the control philosophy for the waste retrieval system for tanks 241-AP-102 (AP-102) and 241-AP-104 (AP-104). This DOO will provide a basis for the detailed design of the Retrieval Control System (RCS) for AP-102 and AP-104 and establishes test criteria for the RCS. The test criteria will be used during qualification testing and acceptance testing to verify operability.

RIECK, C.A.

1999-02-25

304

The Inter American Press Association as Champion of Press Freedom: Reality or Rhetoric? The Bolivian Experience, 1952-1973.  

ERIC Educational Resources Information Center

|Each year a committee on freedom of the press, established in 1946 by the Inter American Press Association (IAPA), exposes those countries which it feels do not have freedom of the press. In 1952 Bolivia underwent a social and economic revolution. As a result, angry mobs forced the closure of the two newspapers with the largest circulation in

Knudson, Jerry W.

305

Beam loading effects in the APS booster  

SciTech Connect

Beam loading of the radio-frequency (rf) accelerating cavities is an important consideration in the design and operation of high-current circular particle accelerators and storage rings. The steady-state and transient perturbations of the rf cavity system by the circulating beam can be harmful to the beam and limit the accelerator performance. Transient beam loading effects have been observed soon after injection of the beam into the booster synchrotron of the Advanced Photon Source (APS). Data are presented quantifying the responses of both the beam and the rf cavities to beam loading under various conditions. A preliminary discussion addresses the compensation of these beam loading effects. 3 refs., 3 figs., 1 tab.

Harkay, K.; Lumpkin, A.; Milton, S.; Nassiri, A.; Song, J.; Yang, B.

1996-06-01

306

Remote plunger removal device for small-scale incremental pressing  

SciTech Connect

Small-scale pressing of high explosives (HE) at Los Alamos National Laboratory (LANL) and elsewhere is routinely performed using pneumatic presses. Blast shields provide protection to the operator during the pressing procedure, but safety of the operator is a concern during removal of the plunger, which is currently performed manually. To minimize this risk, very high tolerances between the plunger and the die are required. These tolerances are often very costly, especially in the case of long, relatively narrow dies. The safety issue is an even greater concern with incremental pressing in which cleaning the die between increments is difficult or impossible. To better protect press operators, a device has been designed and constructed to allow remote plunger removal in a standard HE press. In this report the authors describe this modified press that allows remote removal of the plunger.

Burnside, N.J.; Son, S.F.; Asay, B.W.

1997-09-01

307

Vinpocetine inhibits glutamate release induced by the convulsive agent 4-aminopyridine more potently than several antiepileptic drugs.  

PubMed

4-Aminopyridine (4-AP) is a convulsing agent that in vivo preferentially releases Glu, the most important excitatory amino acid neurotransmitter in the brain. Here the ionic dependence of 4-AP-induced Glu release and the effects of several of the most common antiepileptic drugs (AEDs) and of the new potential AED, vinpocetine on 4-AP-induced Glu release were characterized in hippocampus isolated nerve endings pre-loaded with labelled Glu ([3H]Glu). 4-AP-induced [3H]Glu release was composed by a tetrodotoxin (TTX) sensitive and external Ca2+ dependent fraction and a TTX insensitive fraction that was sensitive to the excitatory amino acid transporter inhibitor, TBOA. The AEDs: carbamazepine, phenytoin, lamotrigine and oxcarbazepine at the highest dose tested only reduced [3H]Glu release to 4-AP between 50-60%, and topiramate was ineffective. Vinpocetine at a much lower concentration than the above AEDs, abolished [3H]Glu release to 4-AP. We conclude that the decrease in [3H]Glu release linked to the direct blockade of presynaptic Na+ channels, may importantly contribute to the anticonvulsant actions of all the drugs tested here (except topiramate); and that the significantly greater vinpocetine effect in magnitude and potency on [3H]Glu release when excitability is exacerbated like during seizures, may involve the increase additionally exerted by vinpocetine in some K+ channels permeability. PMID:21737246

Sitges, M; Sanchez-Tafolla, B M; Chiu, L M; Aldana, B I; Guarneros, A

2011-07-07

308

Line blanketed model atmospheres of AP stars. IV - UBV colors and effective temperatures of AP stars  

Microsoft Academic Search

UBV data for Ap stars at a distance less than 100 pc from the sun show that hotter stars lie on or close to the main sequence in the two-color diagram, but that stars with B-V not less than +0.05 lie below it. This behavior is confirmed by model atmospheres of standard peculiar and individual peculiar stars. It is shown

K. Stepien; H. Muthsam

1980-01-01

309

Prevention of aspiration pneumonia (AP) with oral care  

Microsoft Academic Search

AP is a major cause of morbidity and mortality in elderly patients, especially frail elderly patients. The aim of this article is to review effect of oral care, including oral hygiene and improvement of oral function, on the prevention of AP among elderly people in hospitals and nursing homes. There is now a substantial body of work studying the effect

Akio Tada; Hiroko Miura

310

Predictive Validity Study of the APS Reading Test.  

ERIC Educational Resources Information Center

In July 1994, College of the Canyons (COC) in California conducted several predictive validity studies of the College Board Assessment and Placement Services (APS) Reading Test. COC began using the 35-question objective format test in spring 1993. Fall 1993 test scores were used in determining the ability of the APS Reading Test to predict student

College of the Canyons, Santa Clarita, CA.

311

Performance of Project Advance Students on the AP Biology Examination.  

ERIC Educational Resources Information Center

Compared performance of Project Advance biology students (N=60) with Advanced Placement (AP) candidates (N=15,947) nationally on College Entrance Examination Board AP biology test. The research, conducted to determine comparability of the program as valid measures of academic achievement, determined that Project Advance students scored above the

Mercurio, Joseph; And Others

1984-01-01

312

The APS SASE FEL : modeling and code comparison.  

SciTech Connect

A self-amplified spontaneous emission (SASE) free-electron laser (FEL) is under construction at the Advanced Photon Source (APS). Five FEL simulation codes were used in the design phase: GENESIS, GINGER, MEDUSA, RON, and TDA3D. Initial comparisons between each of these independent formulations show good agreement for the parameters of the APS SASE FEL.

Biedron, S. G.

1999-04-20

313

APS for tactical planning in a steel processing company  

Microsoft Academic Search

Purpose The main purpose is to describe and analyse the impact that the implementation of an advanced planning system (APS) has on the tactical planning level at a steel processing company. This is done in terms of analysing changes in the tactical planning processes, effects on company performance, and how the APS is used in a practical planning context.

Martin Rudberg; Ola Cederborg

2011-01-01

314

Tank 241AP104 Grab Sampling and Analysis Plan  

Microsoft Academic Search

This sampling and analysis plan (SAP) identifies characterization objectives pertaining to sample collection, laboratory analytical evaluation, and reporting requirements for samples obtained from tank 241-AP-104. The purpose of this sampling event is to obtain information about the characteristics of the contents of 241-AP-104 required to provide sample material to the Waste Treatment Contractor. Grab samples will be obtained from riser

2000-01-01

315

Development of a superconducting undulator for the APS  

NASA Astrophysics Data System (ADS)

As the western hemisphere's premier x-ray synchrotron radiation source, the Advanced Photon Source (APS) continues to advance the state of the art in insertion device technology in order to maintain record high brightness, especially in the hard x-ray wavelength region. Due to the unique bunch pattern used for normal APS operations and its ultimate capabilities, the APS has chosen superconducting technology for its future hard x-ray undulator sources. In the last several years, the APS in collaboration with the Budker Institute of Nuclear Physics has being developing the technology for planar, small-period superconducting undulators (SCUs). These developments include the design and construction of several prototypes and the construction of the necessary mechanical, vacuum, and cryogenic infrastructure at the APS site. Several prototypes of the SCU magnetic structure have been built and tested. The first SCU is assembled and will be installed in the APS storage ring at the end of 2012. Expected SCU performance in terms of x-ray brightness should noticeably exceed that of existing APS undulators. Immediately after commissioning, the SCU will be used at APS Sector 6 as the radiation source for high-energy x-ray studies.

Ivanyushenkov, Y.; Abliz, M.; Doose, C.; Fuerst, J.; Hasse, Q.; Kasa, M.; Lev, V.; Mezentsev, N.; Syrovatin, V.; Trakhtenberg, E.; Tsukanov, V.; Vasserman, I.; Gluskin, E.

2013-03-01

316

AP-42 ADDITIONS AND REVISIONS - RUBBER PRODUCTS MANUFACTURING  

EPA Science Inventory

This project develops emission factors, etc., for the rubber products industry which are appended to AP-42. AP42 is a massive collection of material which describes processes which generate air emissions and presents emission factors and control effectiveness information. As res...

317

AP-42 ADDITIONS AND REVISIONS - PAVED AND UNPAVED ROAD DUST  

EPA Science Inventory

This project develops emission factors, etc., for paved and unpaved roads which are incorporated into AP-42. AP42 is a massive collection of material which describes processes which generate air emissions and presents emission factors and control effectiveness information. As re...

318

AP-42 ADDITIONS AND REVISIONS - LANDFILLS (COMBUSTION CONTROLS)  

EPA Science Inventory

This project develops emission factors, etc., for landfills, in particular for combustion devices fed by landfill gas, for incorporation into AP-42. AP-42 is a massive collection of information concerning processes which generate air emissions and presents emission factors and co...

319

Design and assessment of the new APS dialyzer (APS-SA series).  

PubMed

Dialyzer performance seems to greatly depend on the hollow-fiber membrane performance, the morphology of the hollow-fiber membrane bundles (e.g., wave-shaped hollow-fiber membrane bundles), and the design of the dialyzer housing. Consequently, we developed the APS dialyzer APS-SA series, equipped with wave-shaped hollow-fiber membrane bundles as an optimal three-dimensional morphology along with new housings, to realize enhanced dialysis performance. Incorporation of a new type of housing, including a full baffle structure and a short taper section, and a new type of morphology for the hollow-fiber membrane bundles have been verified to allow the dialysate to diffuse uniformly along the full baffle panel around the circumference and to fully permeate into the core of the hollow-fiber bundle. As a result, the APS-SA series has been proved to have achieved enhanced diffusion performance and increased clearance of small molecule solutes such as urea and creatinine, compared with conventional dialyzers. This series is expected to provide increased Kt/V values and dialysate-saving performance in future clinical use. PMID:16998705

Fukuda, Makoto; Miyazaki, Miwa; Uezumi, Satoshi; Yoshida, Makoto

2006-01-01

320

[The press as a vehicle for the introduction of a fashionable disease].  

PubMed

Two journalists wrote a book on HPU (haemopyrrol-lactamuria), a hitherto unknown metabolic disease that was alleged to cause a whole range of complaints. The book is based on the ideas of a biochemist who is also the director of a commercial organisation that offers a diagnostic test as well as a therapy (nutrition supplement) for HPU. The release of the book was accompanied by a press release that provoked various publications in both biomedical journals and the lay press. In response to these reports, the director sometimes registered a complaint with the Dutch Council for Journalism, but on other occasions he did not. The content of this book is in no way based on scientific research. In retrospect, it is obvious that the authors, the biochemist and the publishing company have joint commercial ties. All professional standards of scientific research and journalistic decency are thus being violated. In this way, they are doing harm to the independence and integrity of researchers and journalists in the public image. All the activities of the press seem to have been an essential part of a deliberate marketing strategy for the introduction of a non-disease. PMID:14520803

Meulenberg, F

2003-09-01

321

Association analysis between schizophrenia and the AP-3 complex genes.  

PubMed

A susceptibility gene for schizophrenia, dysbindin, is a component of BLOC-1, which interacts with the adaptor protein (AP)-3 complex. As a direct interaction between dysbindin and AP-3 complex was reported, we examined a possible association between 16 SNPs in the AP3 complex genes and schizophrenia using 432 cases and 656 controls. Nominal association between rs6688 in the AP3M1 gene and schizophrenia (chi(2)=6.33, P=0.012, odds ratio=0.80) was no longer positive after correction for multiple testing (corrected P=0.192). The present results suggest that AP3 complex genes might not play a major role in the pathogenesis of schizophrenia in this population. PMID:19481122

Hashimoto, Ryota; Ohi, Kazutaka; Okada, Takeya; Yasuda, Yuka; Yamamori, Hidenaga; Hori, Hiroaki; Hikita, Takao; Taya, Shinichiro; Saitoh, Osamu; Kosuga, Asako; Tatsumi, Masahiko; Kamijima, Kunitoshi; Kaibuchi, Kozo; Takeda, Masatoshi; Kunugi, Hiroshi

2009-05-27

322

The development of beam current monitors in the APS  

SciTech Connect

The Advanced Photon Source (APS) is a third-generation 7-GeV synchrotron radiation source. The precision measurement of beam current is a challenging task in high energy accelerators, such as the APS, with a wide range of beam parameters and complicated noise, radiation, and thermal environments. The beam pulses in the APS injector and storage ring have charge ranging from 50pC to 25nC with pulse durations varying from 30ps to 30ns. A total of nine non- intercepting beam current monitors have been installed in the APS facility (excluding those in the linac) for general current measurement. In addition, several independent current monitors with specially designed redundant interlock electronics are installed for personnel safety and machine protection. This paper documents the design and development of current monitors in the APS,. discusses the commissioning experience in the past year, and presents the results of recent operations.

Wang, X.; Lenkszus, F.; Rotela, E.

1995-07-01

323

Method for hot press forming articles  

DOEpatents

This disclosure relates to an improved method for achieving the best bond strength and for minimizing distortion and cracking of hot pressed articles. In particular, in a method for hot press forming both an outer facing circumferential surface of and an inner portion of a hub, and of bonding that so-formed outer facing circumferential surface to an inner facing circumferential surface of a pre-formed ring thereby to form an article, the following improvement is made. Normally, in this method, the outside ring is restrained by a restraining sleeve of ring-shaped cross-section having an inside diameter. A die member, used to hot press form the hub, is so-formed as to have an outside diameter sized to engage the inside diameter of the restraining sleeve in a manner permitting relative movement therebetween. The improved method is one in which several pairs of matched restraining sleeve and die member are formed with each matched pair having a predetermined diameter. The predetermined diameter of each matched pair is different from another matched pair by stepped increments. The largest inside diameter of a restraining sleeve is equal to the diameter of the outer facing circumferential surface of the hub. Each pair of the matched restraining sleeve and die member is used to form an article in which an inside hub is bonded to an outside ring. The several samples so-formed are evaluated to determine which sample has the best bond formed between the hub and the ring with the least or no cracking or distortion in the ring portion of the article. Thereafter, the matched restraining sleeve and die member which form the article having the best bonding characteristics and least distortion cracking is then used for repeated formations of articles.

Baker, Robert R. (Livonia, MI); Hartsock, Dale L. (Livonia, MI)

1982-01-01

324

The Ebb and Flow of the Liberalization of the Jordanian Press: 1985-1997.  

ERIC Educational Resources Information Center

|Contributes to scholarship on the complexities of press freedom in non-Western nations. Discusses the context of press freedom in Jordan; the press before the 1989 liberalization; factors that favored press liberalization in 1989; the 1993 press law; the "Temporary Law for the Year 1997"; press reaction to the amendments; and factors mitigating

Najjar, Orayb Aref

1998-01-01

325

Abstracts of Suburban Press Research Series Papers Produced by the Suburban Press Research Center from July 1966 to February 1973. Suburban Press Research Series No. 14.  

ERIC Educational Resources Information Center

|Abstracts of 13 research investigations, speeches, and bibliographic resources, collected by the Suburban Press Research Center, are provided in this paper. Topics of discussion include the following aspects of the suburban press: pretrial coverage, characteristics of communities served by suburban newspapers, science news coverage, the role of

Northern Illinois Univ., De Kalb. Suburban Press Research Center.

326

APS Position Statements- APS Guiding Principles for the Care and Use of Vertebrate Animals in Research and Training  

NSDL National Science Digital Library

The Guiding Principles for the Care and Use of Vertebrate Animals in Research and Training are an updated version of a document first adopted by the APS Council in 1953. The Guiding Principles represent a code of ethics for APS members who work with animals. They provide a framework intended to promote the humane treatment of animals and are also used to evaluate research submitted for publication in APS journals. The update is intended to clarify certain elements of the Guiding Principles and make them easier to apply in practical situations. In addition, because the Guiding Principles are based upon U.S. animal welfare requirements, the update adds provisions to address the fact that other countries have different animal welfare requirements. This change was needed because of the increasing number of physiologists from around the world who are joining the APS and submitting articles for publication in APS journals.

2010-07-16

327

Residual radiation studies at AP0  

SciTech Connect

The radiation environment at the NuMI experiment has received a lot of attention in the last few years in preparation for project construction. One important issue is the induced radioactivation of the components in the beam line and the shielding materials. This arises from irradiation by hadrons that are generated in the target. Since the level of the residual activity has to be considered when determining access procedures for maintenance during NuMI operation, an understanding of the properties of the remnant radiation is important. To this end, experimental studies were performed in the target vault at AP0 which is similar in design to the NuMI target area. Here 120 GeV protons bombard a target, generating the hadrons that produce the induced radioactivity. Two sets of samples each consisting of three small cylindrical or rectangular solids of iron and steel, one sample of aluminum, and one of concrete were irradiated. One set was hung just below the bottom of a module near the lithium lens (in-vault), and the other was placed on top of the modules downstream of this location (above-vault), just beneath the movable concrete roof of the vault at AP0. Further, four thin activation foils of Au, Au+Cd, In, and Al (along with small disks of the same iron, aluminum, and concrete samples discussed above) were mounted on four 10.2 cm diameter Al disks, one placed on the in-vault module and three at above-vault downstream locations as well. The radioactivity of all these materials on the 10.2 cm Al disks was determined at the Radioisotope Analysis Facility in an attempt to characterize the radionuclides produced during irradiation. The activities of the thin foils were employed in an effort to unfold a spectrum of the neutrons produced during the hadronic cascades in the target. The MARS Monte Carlo code (MO95, MO00) was used to predict and analyze the residual radiation produced during the beam irradiation. New subroutines have been developed for the MARS14 version providing reliable estimation of residual dose rates in arbitrary composite materials for arbitrary irradiation and cooling times (RA01). The results of the simulations have been compared with the measurements in Ref. (RA01) and this comparison will be summarized here.

Alexander J Elwyn et al.

2002-06-19

328

Methamphetamine-induced changes in AP-1 binding and dynorphin in the striatum: correlated, not causally related events?  

PubMed

Activation of D1 dopamine (DA) receptors in the striatum increases the expression of the opioid neuropeptide, dynorphin (DYN). While cAMP is generally accepted as a second messenger in this signal transduction pathway, the role of Fos/FRA proteins and AP-1 binding in mediating D1 receptor-induced changes in DYN expression remains uncertain. In this study, DYN peptide and mRNA levels, as well as Fos/FRA proteins and AP-1 DNA binding activity, were measured in individual animals following acute challenge with the psychostimulant drug methamphetamine (METH). METH caused an initial decrease in striatal levels of DYN A, reflecting increased peptide release. Six hours postinjection, DYN mRNA levels were significantly elevated by METH as compared to vehicle-injected controls. At the same time, these drugs increased the expression of Fos/FRA-ir proteins, in particular the 35- and 40-kDa molecular weight species, and increased binding to the AP-1 DNA element. Analyses of the time course of METH's effects revealed that DYN mRNA levels, Fos/FRA proteins and AP-1 binding activity showed variable increases by 3 h but all were significantly elevated above control levels by 6 h posttreatment. The D1-specific antagonist, SCH 23390, completely blocked the METH-induced changes in DYN peptide and mRNA levels while a D2 receptor antagonist (sulpiride) had little or no effect. These data indicate that stimulant drugs such as METH increase the expression of DYN and AP-1 factors in the striatum via a D1 receptor-mediated mechanism. However, the finding that AP-1 binding merely paralleled, but did not precede, the increase in DYN expression, as would be expected if it were mediating increased gene transcription, suggests these may be correlative, not causally related events. PMID:9116798

Bronstein, D M; Pennypacker, K R; Lee, H; Hong, J S

329

Where is the British national press?  

PubMed

Although globalization has highlighted the danger of conflating state, society and nation, sociologists remain insufficiently alert to such banal nationalism. Newspapers offer a strong test case of the extent of diversity in the construction of state, national and social boundaries, since Billig and Anderson have argued they comprise a special case where their orientation to an audience simultaneously located in a state, society and nation allows them to reproduce a sense of national identity. However, despite the commonsense obviousness of the term, it proves remarkably difficult to define what the 'British national press' might comprise. Circulation density of titles varies substantially across different parts of the UK and editorial copy is altered to address diverse 'national' readerships. 'British' newspapers also circulate in other states, especially the Republic of Ireland. After reviewing how newspapers might be defined as 'national' and/or 'British', we conclude that both Anderson and Billig over-estimate the congruence, relevance and obviousness of state, society and national boundaries. If the conceptualization of such boundaries is problematic in the case of the press, it follows that it must be still more so for most other objects of sociological analysis, including that of 'society' itself. PMID:17610619

MacInnes, John; Rosie, Michael; Petersoo, Pille; Condor, Susan; Kennedy, James

2007-06-01

330

Academic integrity: "accepted," "in press," or unacceptable?  

PubMed

In this issue, Grimm and Maxfield report the results of an analysis of the outcomes of manuscripts listed as "provisionally accepted," "accepted," "in press," and "submitted" on applications to a university radiology residency program. Their surprising finding that one-third of manuscripts listed as "accepted" or "in press" were not published two years after being included on an application raises questions about the reasons for these discrepancies.The authors of this commentary argue that one explanation for these findings is that some applicants deliberately misrepresented facts in order to be seen as more attractive candidates. After examining the professionalism implications of the study by Grimm and Maxfield, the authors offer recommendations for addressing lapses in students' professionalism early on. They recommend that medical school admissions and teaching faculty establish clear and unshakable expectations that untruths will not be tolerated regardless of the difficult administrative challenges that may ensue. Further, medical school admissions committees should select entrance criteria that reward collaborative behaviors and honesty in addition to academic achievement. The authors encourage more longitudinal, systematic analyses of potential fabrications in residency applications, with the goal of fostering a culture of trust in medicine. PMID:24072129

Mushlin, Stuart B; Katz, Joel T

2013-11-01

331

Discovery of Abundance Evolution in Magnetic Ap Stars  

NASA Astrophysics Data System (ADS)

The magnetic peculiar A-type stars (mAp) are characterized by their strong, global magnetic fields (of the order of 1 kG or more) and enhanced abundances of Fe-peak and Rare-Earth elements. Recently, Landstreet et al. (2007, 2008) obtained a significant representation of cluster mAp stars in low to high mass bins and were able to demonstrate that mAp stars exhibit a sharp decline in magnetic field strength during their main sequence evolution. This remarkable discovery leads naturally to questions about how atmospheric chemical abundances of mAp stars may evolve during the main sequence phase from zero-age to terminal-age main sequence (ZAMS to TAMS). We have studied a collection of cluster mAp stars that have well known ages. By restricting the study to all stars in a particular mass bin, we are, to a first approximation, evolving a single mAp star in time from ZAMS to TAMS. This abundance analysis was carried out using spectral synthesis that takes into account the effects of the magnetic field. In the 3-4M bin, we have discovered that the chemical abundances of Ti, Cr, Fe, Pr and Nd elements decreases from ZAMS to TAMS for the mAp stars.

Bailey, Jeffrey; Landstreet, J. D.

2013-01-01

332

Raising the acceptance of the AP2-line  

SciTech Connect

The 120 GeV Main Ring proton beam collides with the target at the end of the AP-1 line and creates antiprotons and other secondary particles. The AP-2 line transfers the negative particles from the target to the Debuncher. To provide a bigger antiproton stack size in the Accumulator, both the Debuncher as well as the AP-2 line acceptance have to be raised. This is a proposal for the improvement of the AP-2 line acceptance. The first part of the memo presents an acceptance examination of the existing AP-2 line by computer simulation, while the second presents a short proposal for aperture corrections. The computer program TURTLE was used to trace antiprotons through the AP-2 line without taking into account other negative charged particles. Betatron functions were obtained from the output of the SYNCH computer program. The SYNCH program was also used to check the dispersion match between the AP-2 line and the Debuncher. 3 refs., 6 figs., 5 tabs.

Trbojevic, D.

1989-04-05

333

BioCAT undulator beamline at APS  

NASA Astrophysics Data System (ADS)

The Biophysics Collaborative Access Team (BioCAT) project will be an outstanding research facility for biological small angle scattering, non-crystalline diffraction, and x-ray absorption spectroscopy at the Advanced Photon Source, Argonne National Labs. BioCAT operates as an NIH Research Resource under a cooperative agreement with NIH. BioCat has an aggressive program of core and collaborative research, service, and training. Central to the facility is the undulator beam line (designed by G. Rosenbaum, Argonne National Labs) capable of delivering ca. 1013-1014 ph/s to the sample. Focusing optics will allow focal spot ranges from 1.53.5 mm to 3080 micron, independently adjustable in the vertical and horizontal direction. Up to 8 m camera lengths can be accommodated in the 12m experimental enclosure. The accessible beam energy range will be from 3.5-13 keV using the undulator fundamental and 10-40 keV using the third harmonic. Energy resolution will exceed 210-4 ?E/E. Detectors will include image plates, CCD detectors and some novel detectors designed to accommodate the high count rates expected at the APS. The multi-element detector will be a very high count-rate (up to 109 ph/s global), one dimensional detector optimized for scattering applications. We are also developing a multilayer analyzer detector which maximizes solid angle of collection with high background rejection for biological spectroscopy applications.

Bunker, G. B.; Irving, T.; Black, E.; Zhang, K.; Fischetti, R.; Wang, S.; Stepanov, S.

1997-07-01

334

KCAT, Xradia, ALS and APS Performance Summary  

SciTech Connect

At Lawrence Livermore National Laboratory (LLNL) particular emphasis is being placed on the nondestructive characterization (NDC) of components, subassemblies and assemblies of millimeter-size extent with micrometer-size features (mesoscale). These mesoscale objects include materials that vary widely in composition, density, geometry and embedded features. Characterizing these mesoscale objects is critical for corroborating the physics codes that underlie LLNL's Stockpile Stewardship mission. In this report we present results from our efforts to quantitatively characterize the performance of several x-ray systems in an effort to benchmark existing systems and to determine which systems may have the best potential for our mesoscale imaging needs. Several different x-ray digital radiography (DR) and computed tomography (CT) systems exist that may be applicable to our mesoscale object characterization requirements, including microfocus and synchrotron systems. The systems we have benchmarked include KCAT (LLNL developed) and Xradia {mu}XCT (Xradia, Inc., Concord, CA), both microfocus systems, and Beamline 1-ID at the Advance Photon Source (APS) and the Tomography Beamline at the Advanced Light Source (ALS), both synchrotron based systems. The ALS Tomography Beamline is a new installation, and the data presented and analyzed here is some of the first to be acquired at the facility. It is important to note that the ALS system had not yet been optimized at the time we acquired data. Results for each of these systems has been independently documented elsewhere. In this report we summarize and compare the characterization results for these systems.

Waters, A; Martz, H; Brown, W

2004-09-30

335

Diagnostics for the APS undulator test line  

SciTech Connect

One of the research and development thrusts at the Advanced Photon Source (APS) is to use an rf gun as a low-emittance electron source for injection into the 100- to 650-MeV linac subsystem and subsequent transport to an undulator test area. This configuration would combine the acceleration capability of the 200-MeV S-band electron linac and the in-line 450-MeV positron linac that normally provide positrons to the positron accumulator ring (PAR). A transport line that bypasses the PAR will bring the electrons to the undulator test area. Characterization techniques will be discussed for the electron beam with a normalized, rms emittance of <10 {pi} mm mrad (l{sigma}) at micropulse charges of up to 350 pC and micropulse durations of {approximately}5 ps (FWHM). Preservation of such beam properties will be critical. The diagnostics planned, with resolutions in parentheses, include the beam position monitors based on stripline pickups (100 {mu}m), current monitors based on a transformer (60 {mu}A), beam profile monitors (25 {mu}m FWHM), and bunch length monitor based on a streak camera (2 ps). Tests proposed include measurement of particle beam transport effects (at one-tenth the storage ring beam rigidity) caused by small undulator field errors.

Lumpkin, A.H.; Ciarlette, D.; Kahana, E.; Patterson, D.; Sellyey, W.; Wang, X.

1993-11-01

336

Eastman, AP start on coal unit  

SciTech Connect

Eastman Chemical and Air Products and Chemicals (AP) have started construction of a $214-million, coal-to-methanol demonstration unit at Eastmans site in Kingsport, TN. The project is part of the Department of Energy`s clean coal technology program and is receiving $93 million in federal support. The demonstration unit-which will have a methanol capacity of 260 tons/day-will use novel catalyst technology for converting coal-derived synthesis gas (syngas) to methanol. Unlike conventional technology that processes syngas through a fixed bed of dry catalyst particles, the liquid-phase methanol process converts the syngas in a single vessel containing catalysts suspended in mineral oil. The companies say the innovation allows the process to better able handle the gases from coal gasifiers and is more stable and reliable than existing processes. Eastman says it will use the methanol produced by the plant as a chemical feedstock. It currently uses methanol as an intermediate in making acetic anhydride and dimethyl terephthalate. In addition, the companies say the methanol will be evaluated as a feedstock in making methyl tert-butyl ether for reformulated fuels. Eastman also says it will evaluate coproducing dimethyl ether (DME) with the methanol. DME can be used as a fuel additive or blended with methanol for a chemical feedstock, according to Eastman.

NONE

1995-10-25

337

AP helical stability in salt solutions  

NASA Astrophysics Data System (ADS)

Protein dynamics depends on the environment and the inclusion of salts in the simulation of folding/unfolding becomes extremely necessary when comparing energy barriers or reaction rates with experimental results. The aim of this study is to investigate the effects of three sodium salts: NaClO4,NaCl and Na2SO4 on the helical stability of AP, a mainly alanine peptide. The dependence of the peptide helical stability on the environment has been studied using Replica Exchange Molecular Dynamics (REMD) simulations, Circular Dichroism (CD) and Ultraviolet Raman Resonance Spectroscopy (UVRS) experiments. It was found that NaClO4 solution strongly stabilizes the helical states and that the order in which sodium salts stabilize the peptide helical states follows a reverse Hofmeister Series (ClO4^- < Cl^- < SO4^2-). Another interesting result found is that ClO4^- ions are attracted to the backbone; Cl^- ions are repelled while SO4^2- ions are attracted to the positive side chains. A thorough investigation of the ion effects on the first and second solvation water along with the Kirkwood-Buff theory for solutions allowed us to explain the physical mechanisms involved in the observed ion specific effects.

Asciutto, Eliana; Xiong, Kan; Asher, Sanford; Madura, Jeffry

2009-03-01

338

Regional differences in the effects of isoflurane on neurotransmitter release  

PubMed Central

Stimulus evoked neurotransmitter release requires that Na+ channel-dependent nerve terminal depolarization be transduced into synaptic vesicle exocytosis. Inhaled anesthetics block presynaptic Na+ channels and selectively inhibit glutamate over GABA release from isolated nerve terminals, indicating mechanistic differences between excitatory and inhibitory transmitter release. We compared the effects of isoflurane on depolarization-evoked [3H]glutamate and [14C]GABA release from isolated nerve terminals prepared from four regions of rat CNS evoked by 4-aminopyridine (4AP), veratridine (VTD), or elevated K+. These mechanistically distinct secretegogues distinguished between Na+ channel- and/or Ca2+ channel-mediated presynaptic effects. Isoflurane completely inhibited total 4AP-evoked glutamate release (IC50=0.42 0.03 mM) more potently than GABA release (IC50=0.56 0.02 mM) from cerebral cortex (1.3-fold greater potency), hippocampus and striatum, but inhibited glutamate and GABA release from spinal cord terminals equipotently. Na+ channel-specific VTD-evoked glutamate release from cortex was also significantly more sensitive to inhibition by isoflurane than was GABA release. Na+ channel-independent K+-evoked release was insensitive to isoflurane at clinical concentrations in all four regions, consistent with a target upstream of Ca2+ entry. Isoflurane inhibited Na+ channel-mediated (tetrodotoxin-sensitive) 4AP-evoked glutamate release (IC50=0.30 0.03 mM) more potently than GABA release (IC50=0.67 0.04 mM) from cortex (2.2-fold greater potency). The magnitude of inhibition of Na+ channel-mediated 4AP-evoked release by a single clinical concentration of isoflurane (0.35 mM) varied by region and transmitter: Inhibition of glutamate release from spinal cord was greater than from the three brain regions and greater than GABA release for each CNS region. These findings indicate that isoflurane selectively inhibits glutamate release compared to GABA release via Na+ channel-mediated transduction in the four CNS regions tested, and that differences in presynaptic Na+ channel involvement determine differences in anesthetic pharmacology.

Westphalen, Robert I.; Kwak, No-Bong; Daniels, Keir; Hemmings, Hugh C.

2011-01-01

339

Long periods in two Kepler roAp stars  

NASA Astrophysics Data System (ADS)

We analyse over three years of Kepler photometry for the two roAp stars KIC 10483436 and KIC 10195926. Our aim is to detect possible unexpected low frequencies and to determine the frequency and amplitude variations of the roAp pulsations. Both stars have frequencies close to, but not exactly equal to, half the frequency of rotation with highly variable amplitudes. The origin of this variation is at present not known. In KIC 10483436, the main roAp pulsation is highly variable in frequency, but none of the other modes vary in this way.

Balona, L. A.

2013-09-01

340

The effects of APS star tracker detection sensitivity  

NASA Astrophysics Data System (ADS)

Detection sensitivity is an important parameter of star tracker, which can express detecting limit of the weakest detected visual star magnitude. In this paper, the expressions of APS star detected signal and APS noise are given, so signal-noise ratio (SNR) of star tracker can be obtained. And the detection sensitivity model is obtained from SNR criterion of star target detected, star detecting probability is analyzed. Moreover the evaluation modal of the detection sensitivity in star system is deducted. The effects of detection sensitivity of APS star tracker were discussed.

Zhang, Huaxun; Li, Jie

2008-12-01

341

A new gap separation mechanism for APS insertion devices.  

SciTech Connect

A new gap separation mechanism for use with the standard Advanced Photon Source (APS) 3.3-cm-period undulator magnetic structures has been designed and built and the first system has been installed in the APS storage ring. The system allows a minimum magnetic gap of 10 mm for use with the APS 8-mm insertion device vacuum chambers. The mechanism is a bolted steel frame structure with a simple 4-motor mechanical drive train. The control system uses servomotors with incremental rotary encoders and virtual absolute linear encoders.

Trakhtenberg, E. M.; Tcheskidov, V.; Den Hartog, P. K.; Deriy, B.; Erdmann, M.; Makarov, O.; Moog, E. R.

1999-10-25

342

30. BUILDING NO. 527, DEHYDRATING PRESSES, LOOKING SOUTH. ALUMINUM NARROWGUAGE ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

30. BUILDING NO. 527, DEHYDRATING PRESSES, LOOKING SOUTH. ALUMINUM NARROW-GUAGE GONDOLA CAR IN LEFT BACKGROUND BROUGHT MOISTENED GUN COTTON FROM REST HOUSE (BUILDING NO. 320-B) IN CANS. (ONE OF THESE CANS IS ON UNLOADING PLATFORM RUNNING BESIDE PRESSES). CONTENTS OF CANS WERE UNLOADED INTO PRESSES BY HAND. - Picatinny Arsenal, 500 Area, Powder Factory & Power House, State Route 15 near I-80, Dover, Morris County, NJ

343

Inductive hot-pressing of titanium and titanium alloy powders  

Microsoft Academic Search

Inductive hot-pressing is a field-assisted sintering process (FAST) in which an electrical current is used to enhance the densification of the powder. Inductive hot-pressing could be employed to enable titanium powder to reach a higher density in less time than the pressing and sintering process. In this study, titanium and titanium alloy powders with different features were processed by means

L. Bolzoni; E. M. Ruiz-Navas; E. Neubauer; E. Gordo

344

Elimination of spatial interference in PRESS-localized editing spectroscopy.  

PubMed

Unambiguous detection of gamma-amino butyric acid (GABA) in the human brain is hindered by low concentration and spectral overlap with other metabolites. The popular MEGA-PRESS (PRESS: point-resolved spectroscopic sequence) method allows spectral separation of GABA from other metabolites, but suffers from a significant signal-to-noise ratio (SNR) reduction due to the 4-compartment artifact. An alternative PRESS localization technique (PRESS+4) was investigated and compared to MEGA-PRESS using numerical simulations, phantom, and in vivo experiments. It was shown that while the MEGA-PRESS method suffers significant signal loss ( approximately equal 20% for the difference spectrum), GABA signal intensity in PRESS+4 is reduced by only 2% compared to the nonlocalized condition at 4T. The improved method retains important features of the popular MEGA-PRESS such as additional water suppression and macromolecular elimination as demonstrated in human brain experiments. This method is not limited to GABA J-difference editing, but can be applied in any PRESS-based experiments. It should prove particularly useful at higher field, where the 4-compartment artifact is especially detrimental. PMID:17899586

Kaiser, Lana G; Young, Karl; Matson, Gerald B

2007-10-01

345

Technique for Removal of Malpositioned Ex-PRESS Glaucoma Device.  

PubMed

PURPOSE:: To report a simple technique for removal of malpositioned Ex-PRESS miniature glaucoma filtration device. PATIENT AND METHODS:: A patient who underwent removal of a malpositioned Ex-PRESS shunt from the right eye with wound revision. RESULTS:: Description of step-by-step technique for removal of the Ex-PRESS shunt. The site healed well and a tube shunt was inserted 6 weeks later for intraocular pressure control. CONCLUSIONS:: This technique may assist surgeons in the safe and controlled removal of an Ex-PRESS shunt in cases of malpositioning, impending exposure, or extrusion. PMID:23221910

Khouri, Albert S; Khan, Mohemmed Nazir; Fechtner, Robert D; Vold, Steven D

2012-12-01

346

Articles Pertinent to the Campus Press: A Selected Annotated Bibliography.  

ERIC Educational Resources Information Center

|Lists and annotates articles dealing with such topics as advertising, broadcasting, editorial policy and methods, journalism education, journalism opportunities, media management, press law, and public relations. (GW)|

Ardoin, Birthney; And Others

1978-01-01

347

Free Press: Beginner's Guide to Media Reform  

NSDL National Science Digital Library

Started in 2002 by author and professor Robert W. McChesney, the Free Press website is a clearinghouse of online material about the U.S. media reform movement. Some of the highlights of the site include profiles of all the organizations active in media reform, a detailed Learn About Media section with annotated background information, and original editorial content. One section that visitors will definitely want to take a close look at is the Media Policy area. Here users can receive current news information about the debates over media ownership as reflected by policy making decisions within the FCC, and also throughout the United States, and across the globe. The section dedicated to organizations is quite well-developed, and allows visitors to learn about various specific organizations interested in media reform, and how they may become involved with their work.

Mcchesney, Robert W.

348

Laser cutting of pressed explosives: Revision 1  

SciTech Connect

We have used a femtosecond laser beam to make cuts through small pressed pellets of six common explosives. The laser system, which produces 100 fs pulses of 820 nm light at a repitition rate of 1 kHz, was intitially developed for cutting metal. The advantage of using a femtosecond laser for cutting is that the cutting process transfers virtually no heat to the material that is being cut and produces almost no waste. We used LX-16 explosive (96% PETN/4% FPC 461 binder) for out intial experiments because PETN is one of the most sensitve of the secondary explosives. In some of the experiments the beam first cut through the HE pellet and then through a stainless steel substrate and in other experiments the beam first cut through the stainless steel and then through the pellet. We also cut through pellets that were not backed by a substrate. No evidence of reaction was observed in any of the LX-16 pellets. In addition to LX-16 we cut pellets of LX-14 (95.5% HMX/4.5% Estane), LX-15 (95% HNS/5% Kel-F), LX-17 (92.5% TATB/7.5% Kel-F), PBX-9407 (94% RDX/6% Exon 461), and pressed TNT with no evidence of reaction. The HE was easily cut at low power levels with one or two sweeps at 0.5 W average power sufficing to cut most of the pellets. There is obvioulsy much more work to be done before laser machining of explosives becomes a reality, but the results of these intitial experiments indicate that laser machining of explosives may be an attractive option for explosives processing.

Roeske, F., Jr.; Banks, R.E.; Armstrong, J.P.; Feit, M.D.; Lee, R.S.; Perry, M.D.; Stuart, B.C.

1998-05-04

349

Tank 241-AP-102 Vapor Sampling and Analysis Plan.  

National Technical Information Service (NTIS)

This tank sampling and analysis plan (SAP) identifies characterization objectives pertaining to sample collection, laboratory analytical evaluation, and reporting requirements for vapor samples from the head space of tank 241-AP-102. Sampling will be perf...

A. M. Templeton

2001-01-01

350

Tank characterization report for double shell tank 241-AP-104  

SciTech Connect

This document summarizes the information on the historical uses, present status, and the sampling and analysis results of waste stored in Tank 241-AP-104. This report supports the requirements of Tri-Party Agreement Milestone M-44-09.

Winkelman, W.D., Westinghouse Hanford

1996-08-07

351

Exercise Physiology-Fisiologia del Ejercicio - 2012 APS Video Contest  

NSDL National Science Digital Library

The Viewer's Choice award-winning video from the 2012 APS Video Contest. This video, which is recorded in english with spanish subtitles, describes cardiovasuclar adaptations that occur during exercise.

Facundo Mendes Garrido Abregu (Universidad de Buenos Aires); Sofia Aguirre (Universidad de Buenos Aires)

2012-05-02

352

A Review of AP Calculus Graphing Calculator Skills  

NSDL National Science Digital Library

Review material on graphing calculator use from the College Board AP Calculus Course Description. The problems are mostly AB level. The page also contains a brief historical remark about Maria Gaetana Agnesi.

353

EIA new releases, November--December 1995  

SciTech Connect

Thus publication contains information compiled by the Energy information administration (EIA) on the following topics: heating fuel supplies; alternative fuel vehicles; natural gas production; clean air laws and coal transportation; EIA`s world Wide Web Site; EIA`s CD-ROM; Press Releases; Microfiched products; electronic publishing; new reports; machine-readable files; how to order EIA publications; and Energy Data Information Contracts.

NONE

1996-02-09

354

INTEGRAL Science Data Centre to be presented to the press  

NASA Astrophysics Data System (ADS)

The task of INTEGRAL, the most sensitive gamma-ray observatory ever launched, will be to gather some of the most energetic radiation that comes from space. It will pinpoint and study gamma-ray sources in unprecedented detail and will help to solve some of the biggest mysteries in astronomy: INTEGRAL will investigate the origin of enigmatic gamma-ray bursts, brief but extremely powerful releases of energy, and will bring much new information on stellar explosions and black holes. Not only does INTEGRAL tell us about places where we could not live, it also tell us about the processes that made the Universe habitable, such as the formation of chemical elements. The INTEGRAL Science Data Centre (ISDC), located near Geneva, represents the key element in the exploitation and analysis of the data that will come from INTEGRAL during the two years planned for in-orbit operations. In the centre, the data will be analysed, formatted and made accessible to the worldwide astronomical community. Such fundamental work on INTEGRAL data guarantees that data can be exploited by a wide community of astronomers, including those who are not familiar with the instrumentation used for gamma-ray observations. The ISDC is supported and funded by a dozen institutes in Europe and the United States (the ISDC consortium). The press conference on 11 April marks the end of the centre's development phase and the start of its operational phase. The presence of the ISDC in Switzerland represents a particular opportunity for Swiss scientists, who will participate in a special way to the development of high-energy particle astrophysics, as a result of having privileged access to INTEGRAL data. Speakers at the press conference will include Professor T. Courvoisier (Geneva Observatory, Principal Investigator of the INTEGRAL Science Data Centre), Doctor P. Creola, (Head of Swiss Space Office), and Professor D. Southwood (Director of Science at the European Space Agency). Note to editors INTEGRAL, ESA's International Gamma-Ray Astrophysics Laboratory, will be launched in October 2002 on a Proton rocket from Baikonour, Kazakhstan. The spacecraft is currently subject to final testing at ESA's European Space Research & Technology Centre (ESTEC) in Noordwijk, the Netherlands, while the ground segment facilities - from which INTEGRAL operations will be controlled - are preparing for final review in June. The spacecraft will be shipped to the launch site in August 2002.

2002-03-01

355

Roles of AP-2 in Clathrin-Mediated Endocytosis  

PubMed Central

Background The notion that AP-2 clathrin adaptor is an essential component of an endocytic clathrin coat appears to conflict with recent observations that substantial AP-2 depletion, using RNA interference with synthesis of AP-2 subunits, fails to block uptake of certain ligands known to internalize through a clathrin-based pathway. Methodology/Principal Findings We report here the use of in vivo imaging data obtained by spinning-disk confocal microscopy to study the formation of clathrin-coated structures at the plasma membranes of BSC1 and HeLa cells depleted by RNAi of the clathrin adaptor, AP-2. Very few clathrin coats continue to assemble after AP-2 knockdown. Moreover, there is a total absence of clathrin-containing structures completely lacking AP-2 while all the remaining coats still contain a small amount of AP-2. These observations suggest that AP-2 is essential for endocytic coated-pit and coated-vesicle formation. We also find that AP-2 knockdown strongly inhibits light-density lipoprotein (LDL) receptor-mediated endocytosis, as long as cells are maintained in complete serum and at 37C. If cells are first incubated with LDL at 4C, followed by warming, there is little or no decrease in LDL uptake with respect to control cells. LDL uptake at 37C is also not affected in AP-2 depleted cells first deprived of LDL by incubation with either serum-starved or LDL-starved cells for 24 hr. The LDL-deprived cells display a significant increase in endocytic structures enriched on deeply invaginated tubes that contain LDL and we suggest that under this condition of stress, LDL might enter through this alternative pathway. Conclusions/Significance These results suggest that AP-2 is essential for endocytic clathrin coated-pit and coated-vesicle formation. They also indicate that under normal conditions, functional endocytic clathrin coated pits are required for LDL internalization. We also show that under certain conditions of stress, cells can upregulate alternative endocytic structures with the potential to provide compensatory trafficking pathways.

Zhang, Rongying; Kirchhausen, Tomas

2010-01-01

356

An overview of the APS 352-MHz rf systems  

SciTech Connect

The Advanced Photon Source (APS) is a 7-GeV full energy positron storage ring for generating synchrotron radiation with an injector. The booster synchrotron rf system consists o a single 1-MW klystron which drives four five-cell cavities at 352 MHz. The storage ring cavities consist of four groups of four single cells powered by two 1-MW klystrons for 100-mA operation. An overview of the operation of the APS 352-MHz rf systems is presented.

Nassiri, A.; Cours, A.; Grelick, A.; Horan, D.; Kang, Y.W.; Kustom, R.L.; Smith, T.L.; Song, J. [Argonne National Lab., IL (United States). Advanced Photon Source

1997-08-01

357

Thermal Decomposition Characteristics of Orthorhombic Ammonium Perchlorate (o-AP)  

SciTech Connect

Preliminary STMBMS and SEM results of the thermal decomposition of AP in the orthorhombic phase are presented. The overall decomposition is shown to be complex and controlled by both physical and chemical processes. The data show that the physical and chemical processes can be probed and characterized utilizing SEM and STMBMS. The overall decomposition is characterized by three distinguishing features: an induction period, and accelerator period and a deceleratory period. The major decomposition event occurs in the subsurface of the AP particles and propagates towards the center of the particle with time. The amount of total decomposition is dependent upon particle size and increases from 23% for {approximately}50{micro}m-diameter AP to 33% for {approximately}200{micro}m-diameter AP. A conceptual model of the physical processes is presented. Insight into the chemical processes is provided by the gas formation rates that are measured for the gaseous products. To our knowledge, this is the first presentation of data showing that the chemical and physical decomposition processes can be identified from one another, probed and characterized at the level that is required to better understand the thermal decomposition behavior of AP. Future work is planned with the goal of obtaining data that can be used to develop a mathematical description for the thermal decomposition of o-AP.

Behrens, R.; Minier, L.

1999-03-01

358

Impression creep behavior of atmospheric plasma sprayed and hot pressed MoSi{sub 2}/Si{sub 3}N{sub 4}  

SciTech Connect

The use of MoSi{sub 2} as a high temperature oxidation resistant structural material is hindered by its poor elevated temperature creep resistance. The addition of second phase Si{sub 3}N{sub 4} holds promise for improving the creep properties of MoSi{sub 2} without decreasing oxidation resistance. The high temperature impression creep behavior of atmospheric plasma sprayed (APS) and hot pressed (HP) MoSi{sub 2}/Si{sub 3}N{sub 4} composites was investigated. Values for steady state creep rates, creep activation energies, and creep stress exponents were measured. Grain boundary sliding and splat sliding were found to be the dominant creep mechanisms for the APS samples while grain boundary sliding and plastic deformation were found to be the dominant creep mechanisms for the HP samples.

Hollis, K.J.; Butt, D.P.; Castro, R.G.

1997-09-01

359

Influence of die variables on cavity press forging loads  

Microsoft Academic Search

Slug, die and process parameters largely determine the load requirements when forging any given part. An earlier report (Balogun 1974) has indicated the effects of flash dimensions on deformation forces during cavity press forging of round mild steel slugs.The current paper discusses the influences of three main die variablesdie friction, extrusion ratio and flash land shape on press forging loads.

S. A. BALOGUN

1975-01-01

360

The Press and the Lincoln-Douglas Debates of 1858.  

ERIC Educational Resources Information Center

|The Lincoln-Douglas debates were significant in the history of political journalism in that new ground was broken by reporters traveling extensively with candidates, making extensive use of shorthand to record campaign speeches, and fighting for the press rights to cover the events. Also, the press coverage preserved the candidates' debates on

Reilly, Tom

361

The press and the political restructuring of Ethiopia  

Microsoft Academic Search

Divisive debates on what constitutes the Ethiopian nation, how the state should be structured and how power should be devolved, have dominated Ethiopia's private press since the ruling party, the Ethiopian Peoples Revolutionary Democratic Front (EPRDF), came to power. The press has served as both a mirror reflecting these issues and a space for literate elites to engage in political

Nicole Stremlau

2011-01-01

362

A hydrothermal hot-pressing method: Apparatus and application  

Microsoft Academic Search

Loose particles occurring in sediment are transformed into sedimentary rock by a process termed lithification, which is a chemical process that reduces the original porosity by compaction and cementation [1]. A hydrothermal hot-pressing method is intended for artificial lithification. In this study, silica powder including mineralizer solution is compressed under hydrothermal conditions from outside an autoclave for hydrothermal hot-pressing and

N. Yamasaki; K. Yanagisawa; M. Nishioka; S. Kanahara

1986-01-01

363

The effect of hot isostatic pressing on cast aluminum  

NASA Astrophysics Data System (ADS)

Aluminum-silicon alloys are the most important commercial aluminum casting alloys, primarily because of their superior casting characteristics. This article discusses the effect of hot isostatic pressing on the mechanical properties of cast aluminum alloy A356. The effect of low-cost Densal hotisostatic pressing is also examined.

Lei, C. S. C.; Frazier, W. E.; Lee, E. W.

1997-11-01

364

A free press is bad news for corruption  

Microsoft Academic Search

This paper tests the proposition that a free press may be a powerful control on corruption. We find evidence of a significant relationship between more press freedom and less corruption in a large cross-section of countries. This result is robust to specification and sample and the relationship is not sensitive to the choice of a particular measure of corruption or

Aymo Brunetti; Beatrice Weder

2003-01-01

365

Analysis of paper pressing : the saturated one-dimensional case  

Microsoft Academic Search

We derive a one-dimensional model that describes pressing of water saturated paper in the press-section of the paper ma- chine. The model involves two nonlinear diffusion equations which are coupled across an internal boundary. Existence and uniqueness as a number of qualitative properties are demonstrated. Further, computational results for some concrete cases are discussed. 1 Introduction and motivation In paper

D Bezanovic; Duijn van CJ; E. F. Kaasschieter

2006-01-01

366

The Emergence and Changing Role of Scholastic Press Associations.  

ERIC Educational Resources Information Center

|Recognizing that scholastic press associations at the regional, state, and national levels enhance and encourage high school journalism, a study was conducted to update a 1980 survey of scholastic journalism/press associations in the United States. Of the 122 organizations originally polled, 54 were reevaluated either by telephone, personal

Hines, Barbara

367

19. REMAINS OF FLYWHEEL OF No. 1 PRESS PUMPING ENGINE. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

19. REMAINS OF FLYWHEEL OF No. 1 PRESS PUMPING ENGINE. GEARS ON EITHER SIDE OF THE FLYWHEEL WERE TURNED INTERMEDIATE GEARS WHICH POWERED THE PUMPS. - U.S. Steel Homestead Works, Press Shop No. 1, Along Monongahela River, Homestead, Allegheny County, PA

368

LA COUVERTURE DE PRESSE ET SES FONCTIONS LGITIMANTES  

Microsoft Academic Search

This paper examines the legitimating function of press cover- age by means of a specific case study of political violence. Dissident actors who resort to violence to achieve their politi- cal goals are generally treated by the authorities as common criminals. This criminal justice model is reproduced and rein- forced in the press by selective focus on specific, narrow topics

Ronald D. Crelinsten

369

Korean and Japanese Press: A Study in Crisis.  

ERIC Educational Resources Information Center

|During a time of crisis, it is instructive to examine the national press of Japan and Korea, two economic allies that view each other with suspicion. The Japanese press is relatively free and liberal-oriented on the domestic scene but is closely aligned with big business and government with regard to international concerns. The South Korean

Ruidl, Richard A.

370

Styles of Image Management During Crises: Justifying Press Censorship  

Microsoft Academic Search

Press freedom is crucial in times of national crisis such as rampant terrorism or war. But press freedom is likely to become a casualty at such times because of legitimate concerns about security for civilians and military personnel and because of fears of compromising the confidentiality of important public policies. What kinds of appeals do partisans and opponents of both

DORIS GRABER

2003-01-01

371

Massachusetts Adviser Urges a National Student Press Rights Drive.  

ERIC Educational Resources Information Center

|Argues that students are being trained to believe that censorship of the press is a good idea. Shows, using two examples dealing with teenage pregnancies and gangs, how students can bring about real change in their school climate through their school newspaper--but only if it is a free press controlled by students, not the administration. (SR)|

Proudfoot, Harry

2000-01-01

372

Deformation characteristics and eigenfrequencies of press-fit acetabular cups  

Microsoft Academic Search

BackgroundElastic deformation of press-fitted acetabular cups during implantation provides primary stability. Excessive deformation can lead to chipping or improper seating of ceramic inlays and is dictated by cup stiffness, which also affects its vibrational characteristics. Purpose was to investigate the influence of cup design on deformation during press-fitting and on vibration properties.

Arne Hothan; Gerd Huber; Cornelius Weiss; Norbert Hoffmann; Michael Morlock

2011-01-01

373

6. VIEW OF THE BRIQUETTING PRESS AND CHIP CLEANING HOOD. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. VIEW OF THE BRIQUETTING PRESS AND CHIP CLEANING HOOD. SCRAPS OF ENRICHED URANIUM FROM MACHINING OPERATIONS WERE CLEANED IN A SOLVENT BATH, THEN PRESSED INTO BRIQUETTS. THE BRIQUETTS WERE USED AS FEED MATERIAL FOR THE FOUNDRY. (4/4/66) - Rocky Flats Plant, General Manufacturing, Support, Records-Central Computing, Southern portion of Plant, Golden, Jefferson County, CO

374

State Free Expression Laws and Scholastic Press Censorship.  

ERIC Educational Resources Information Center

|Surveys high school newspaper advisors, finding remarkably similar attitudes, in states with scholastic freedom of press laws and states without such laws, regarding scholastic press freedom, the way they exercise their duty in overseeing the newspaper, censorship and self-censorship, and controversy over newspaper content. Finds differences in

Paxton, Mark; Dickson, Tom

2000-01-01

375

First Amendment Speech and Press Theory: Preferred Position Postulate Reexamined.  

ERIC Educational Resources Information Center

|If the United States Supreme Court is to exercise its historic role as guardian of the fundamental freedoms flowing from the speech and press clauses of the first amendment, it is imperative that those basic freedoms be placed in a preferred position. The preferred position doctrine provides adequate safeguards for both speech and press

Stonecipher, Harry W.

376

9. DETAILED VIEW OF BRIQUETTING PRESS HOUSED IN A GLOVE ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. DETAILED VIEW OF BRIQUETTING PRESS HOUSED IN A GLOVE BOX. THE PRESS FORMED SCRAP PLUTONIUM METAL FROM FOUNDRY AND FABRICATION PROCESSES INTO SMALL BRIQUETTES. THESE BRIQUETTES BECAME PART OF THE FEED MATERIALS FOR THE FOUNDRY. (5/6/59) - Rocky Flats Plant, Plutonium Fabrication, Central section of Plant, Golden, Jefferson County, CO

377

10. VIEW OF MODULE B, INSTALLATION OF A HYDRAULIC PRESS. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. VIEW OF MODULE B, INSTALLATION OF A HYDRAULIC PRESS. THE PRESS WILL EVENTUALLY BE CONNECTED TO A GLOVE BOX LINE. (9/29/69) - Rocky Flats Plant, Plutonium Manufacturing Facility, North-central section of Plant, just south of Building 776/777, Golden, Jefferson County, CO

378

Quality control of press-powders for engineering ceramics  

Microsoft Academic Search

The present paper deals with a study of the methods and means of evaluation of the macrostructure of granules, compactibility of press-powders, porosity, and green strength of the compacted products. The techniques developed successfully went through laboratory and industrial testing. The properties of press-powders depend on the properties of individual granules, which are aggregates of dispersed particles with binders, lubricants,

A. A. Polyakov

1982-01-01

379

Unproportionally high concentrations of diadenosine triphosphate (Ap 3 A) and diadenosine tetraphosphate (Ap 4 A) in heavy platelets  

Microsoft Academic Search

Platelets from whole blood were separated into five density subpopulations using a discontinuous Percoll gradient. The content of diadenosine triphosphate (Ap3A), diadenosine tetraphosphate (Ap4A), ADP and ATP were determined in the subfractions. The dinucleotides were directly measured in neutralized, acid-soluble extracts of human platelets with a bioluminescence method not requiring any chromatographic step. When comparing the nucleotide contents of the

Jrgen Lthje; Daniela Miller; Adaling Ogilvie

1987-01-01

380

Comparison of ceramic waste forms produced by hot uniaxial pressing and by cold pressing and sintering  

SciTech Connect

Synroc C waste form specimens prepared using the Australian-developed technology are uniaxially pressed in stainless steel bellows at 1200{degrees}C and 20MPa. This produces a material with high chemical and physical durability and with the radioactivity enclosed inside both the waste form and the bellows. An alternative method of producing the ceramic product is to use cold pressing of pellets followed by reactive sintering to provide densification and mineralization. Depending on the scale of waste form preparation required and on the activity level and nature of the waste streams, the cold press and sinter method may have advantages. To evaluate the effects of production method on waste form characteristics, especially resistance to dissolution or leaching of waste elements, we have prepared two simulated waste samples for evaluation. Both samples were prepared from liquid precursor materials (alkoxides, nitrates, and colloidal silica) and then doped with waste elements. The precursor material in each case corresponded to a basic phase assemblage of 60% zirconolite, 15% nepheline, 10% spinel, 10% perovskite, and 5% rutile. One sample was doped with 25% by weight of U; the other with 10% by weight each of U and Gd. Each sample was calcined at 750{degrees}C for 1 hr. in a 3.5% H{sub 2} in N{sub 2} atmosphere. Then one portion of each sample was hot pressed at temperatures ranging from 1120 to 1250{degrees}C and 20MPa pressure in steel bellows. A separate portion of each sample was formed into pellets, cold pressed, and sintered in various atmospheres at 1200{degrees}C to produce final products about 2/3 cm in diameter. Samples were then examined to determine density of the product, grain sizes of the phases, phase assemblage, and the location of the U and Gd in the final phases. Density data indicate that sintering gives good results provided that the samples are held at 200{degrees}C for long enough to allow trapped gases to escape.

Oversby, V.M. [Lawrence Livermore National Lab., CA (United States); Vance, E.R. [Australian Nuclear Science and Technology Organization, Lucas Heights (Australia)

1994-09-01

381

Lifting shoeprints using gelatin lifters and a hydraulic press.  

PubMed

A method for lifting two-dimensional dust footwear marks on rough or porous surfaces, such as cardboard or cloth, using a hydraulic press, was examined. It was found that exerting pressure on the lifter by the press usually improves the quality of the results. When the shoeprints were on rough or soft surfaces, the prints transferred to the gelatin lifters were better than those obtained by the conventional method. In other cases, using the press did not improve the results but was much simpler to apply. Based on the results of this study, the hydraulic press/gelatin lifter method (the "press method") is used at the authors' laboratory, depending on the surface from which the shoeprint is to be lifted. It is the authors' intention to apply the method to other surfaces after finding the optimal pressure for surfaces with loose fibers. PMID:12664996

Shor, Yaron; Tsach, Tsadok; Vinokurov, Asya; Glattstein, Baruch; Landau, Eliezer; Levin, Nadav

2003-03-01

382

Modelling hot-pressing of UO2. Technical report  

SciTech Connect

Final state isostatic hot-pressing of nearly stoichiometric UO2 was investigated. The rate of hot-pressing is linearly dependent on the pressure driving force F=P+2 gamma/r - p, where P and p are the external and internal pressures, respectively, gamma is the average surface energy and r is average pore radius. The apparent activation energy for hot-pressing agrees with that for U bulk diffusion. Grain growth during hot-pressing follows d the ratio to t sup n, where d is the grain diameter, t is time and n approximately equal to 0.2. Grain size is also a function of temperature at constant density. The results indicate that Nabarro-Herring creep is the controlling mechanism of hot-pressing over the range of variables investigated, although the applicability of this model is questioned. The results also show that sintered UO2 can entrap gas that can lead to swelling.

Solomon, A.A.; Cochran, K.M.; Habermeyer, J.A.

1981-03-01

383

PKA-activated ApAF-ApC/EBP heterodimer is a key downstream effector of ApCREB and is necessary and sufficient for the consolidation of long-term facilitation  

PubMed Central

Long-term memory requires transcriptional regulation by a combination of positive and negative transcription factors. Aplysia activating factor (ApAF) is known to be a positive transcription factor that forms heterodimers with ApC/EBP and ApCREB2. How these heterodimers are regulated and how they participate in the consolidation of long-term facilitation (LTF) has not, however, been characterized. We found that the functional activation of ApAF required phosphorylation of ApAF by PKA on Ser-266. In addition, ApAF lowered the threshold of LTF by forming a heterodimer with ApCREB2. Moreover, once activated by PKA, the ApAFApC/EBP heterodimer transactivates enhancer response elementcontaining genes and can induce LTF in the absence of CRE- and CREB-mediated gene expression. Collectively, these results suggest that PKA-activated ApAFApC/EBP heterodimer is a core downstream effector of ApCREB in the consolidation of LTF.

Lee, Jin-A; Lee, Sue-Hyun; Lee, Changhoon; Chang, Deok-Jin; Lee, Yong; Kim, Hyoung; Cheang, Ye-Hwang; Ko, Hyoung-Gon; Lee, Yong-Seok; Jun, Heejung; Bartsch, Dusan; Kandel, Eric R.; Kaang, Bong-Kiun

2006-01-01

384

Transcription factor AP2 and monoaminergic functions in the central nervous system  

Microsoft Academic Search

Summary. In the central nervous system, transcription factor AP-2 family is one of the critical regulatory factors for neural gene expression and neuronal development. Several genes in the monoaminergic systems display AP-2 binding sites in regulatory regions. In addition, brainstem levels of transcription factor AP-2? and AP-2? are positively correlated to monoamine measures in rat forebrain, suggesting a regulatory role

M. Damberg

2005-01-01

385

Engineering work plan for container venting system drill press assembly troubleshooting. Revision 1  

Microsoft Academic Search

This work plan is for troubleshooting the current CVS drill press to ensure that the drill bit assembly doesn`t bind in the press plate. A drill press assembly has been fabricated for the Container Venting System (CVS). The drill bit assembly has bound in the press plate in previous revisions of this design. Initial troubleshooting of the drill press per

Prather

1994-01-01

386

The Watchdog in Nineteenth Century Libel Law: A Common Law Concept of Freedom of the Press.  

ERIC Educational Resources Information Center

|In press law, the individual right of freedom of the press frequently is linked to a public interest or "watchdog" concept of freedom of the press. This concept suggests that the basis for the constitutional protection of press freedom is the role of the press as an institution serving a collective good, as opposed to the traditional view of

Gleason, Timothy W.

387

Loss of Lever Press-Related Firing of Rat Striatal Forelimb Neurons after Repeated Sessions in a Lever Pressing Task  

Microsoft Academic Search

Lateral striatal neurons that fire phasically in relation to active movement of the contralateral forelimb (determined via daily sensorimotor examination) were studied during acquisition of cued lever pressing. Rats were trained to lift the contralateral forepaw from thefloor to press a lever in the presence of a tone. The tone was presented 70 times per day (session) for 18 consecutive

Regina M. Carelli; Martin Wolske; Mark O. West

1997-01-01

388

The Power of the Press: The Effects of Press Frames in Political Campaign News on Media Perceptions  

Microsoft Academic Search

This article discusses how the behaviors, roles, and standards of mainstream journalism are framed in political campaign news and empirically examines applicability and accessibility effects of so-called press frames on individuals' media perceptions, specifically on news information quality and negative aspects of content (cf. Kosicki & McLeod, 1990). Following previous work, we posited that journalists frame the press in three

Paul DAngelo; Matthew Lombard

2008-01-01

389

Hot isostatic press waste option study report  

SciTech Connect

A Settlement Agreement between the Department of Energy and the State of Idaho mandates that all high-level radioactive waste now stored at the Idaho Chemical Processing Plant be treated so that it is ready to move out of Idaho for disposal by the target date of 2035. This study investigates the immobilization of all Idaho Chemical Processing Plant calcine, including calcined sodium bearing waste, via the process known as hot isostatic press, which produces compact solid waste forms by means of high temperature and pressure (1,050 C and 20,000 psi), as the treatment method for complying with the settlement agreement. The final waste product would be contained in stainless-steel canisters, the same type used at the Savannah River Site for vitrified waste, and stored at the Idaho National Engineering and Environmental Laboratory until a national geological repository becomes available for its disposal. The waste processing period is from 2013 through 2032, and disposal at the High Level Waste repository will probably begin sometime after 2065.

Russell, N.E.; Taylor, D.D.

1998-02-01

390

Functional Analysis of AP-2 ? and ?2 Subunits  

PubMed Central

The AP-2 adaptor complex plays a key role in cargo recognition and clathrin-coated vesicle formation at the plasma membrane. To investigate the functions of individual binding sites and domains of the AP-2 complex in vivo, we have stably transfected HeLa cells with wild-type and mutant small interfering RNAresistant ? and ?2 subunits and then used siRNA knockdowns to deplete the endogenous proteins. Mutating the PtdIns(4,5)P2 binding site of ?, the phosphorylation site of ?2, or the YXX? binding site of ?2 impairs AP-2 function, as assayed by transferrin uptake. In contrast, removing the C-terminal appendage domain of ?, or mutating the PtdIns(4,5)P2 binding site of ?2, has no apparent effect. However, adding a C-terminal GFP tag to ? renders it completely nonfunctional. These findings demonstrate that there is some functional redundancy in the binding sites of the various AP-2 subunits, because no single mutation totally abolishes function. They also help to explain why GFP-tagged AP-2 never appears to leave the plasma membrane in some live cell imaging studies. Finally, they establish a new model system that can be used both for additional structure-function analyses, and as a way of testing tagged constructs for function in vivo.

Motley, Alison M.; Berg, Nicola; Taylor, Marcus J.; Sahlender, Daniela A.; Hirst, Jennifer; Owen, David J.

2006-01-01

391

CD2AP Regulates SUMOylation of CIN85 in Podocytes  

PubMed Central

Podocytes are highly differentiated and polarized epithelial cells located on the visceral side of the glomerulus. They form an indispensable component of the glomerular filter, the slit diaphragm, formed by several transmembrane proteins and adaptor molecules. Disruption of the slit diaphragm can lead to massive proteinuria and nephrotic syndrome in mice and humans. CD2AP is an adaptor protein that is important for the maintenance of the slit diaphragm. Together with its paralogue, CIN85, CD2AP belongs to a family of adaptor proteins that are primarily described as being involved in endocytosis and downregulation of receptor tyrosine kinase activity. We have shown that full-length CIN85 is upregulated in podocytes in the absence of CD2AP, whereas in wild-type cells, full-length CIN85 is not detectable. In this study, we show that full-length CIN85 is postranslationally modified by SUMOylation in wild-type podocytes. We can demonstrate that CIN85 is SUMOylated by SUMO-1, -2, and -3 and that SUMOylation is enhanced in the presence of CD2AP. Conversion of lysine 598 to arginine completely abolishes SUMOylation and leads to increased binding of CIN85 to nephrin. Our results indicate a novel role for CD2AP in regulating posttranslational modification of CIN85.

Niedenthal, Rainer; Klaus, Malte; Teng, Beina; Worthmann, Kirstin; King, Benjamin L.; Peterson, Kevin J.; Haller, Hermann

2012-01-01

392

CD2AP regulates SUMOylation of CIN85 in podocytes.  

PubMed

Podocytes are highly differentiated and polarized epithelial cells located on the visceral side of the glomerulus. They form an indispensable component of the glomerular filter, the slit diaphragm, formed by several transmembrane proteins and adaptor molecules. Disruption of the slit diaphragm can lead to massive proteinuria and nephrotic syndrome in mice and humans. CD2AP is an adaptor protein that is important for the maintenance of the slit diaphragm. Together with its paralogue, CIN85, CD2AP belongs to a family of adaptor proteins that are primarily described as being involved in endocytosis and downregulation of receptor tyrosine kinase activity. We have shown that full-length CIN85 is upregulated in podocytes in the absence of CD2AP, whereas in wild-type cells, full-length CIN85 is not detectable. In this study, we show that full-length CIN85 is postranslationally modified by SUMOylation in wild-type podocytes. We can demonstrate that CIN85 is SUMOylated by SUMO-1, -2, and -3 and that SUMOylation is enhanced in the presence of CD2AP. Conversion of lysine 598 to arginine completely abolishes SUMOylation and leads to increased binding of CIN85 to nephrin. Our results indicate a novel role for CD2AP in regulating posttranslational modification of CIN85. PMID:22203040

Tossidou, Irini; Niedenthal, Rainer; Klaus, Malte; Teng, Beina; Worthmann, Kirstin; King, Benjamin L; Peterson, Kevin J; Haller, Hermann; Schiffer, Mario

2011-12-27

393

Multipurpose active pixel sensor (APS)-based microtracker  

NASA Astrophysics Data System (ADS)

A new, photon-sensitive, imaging array, the active pixel sensor (APS) has emerged as a competitor to the CCD imager for use in star and target trackers. The Jet Propulsion Laboratory (JPL) has undertaken a program to develop a new generation, highly integrated, APS-based, multipurpose tracker: the Programmable Intelligent Microtracker (PIM). The supporting hardware used in the PIM has been carefully selected to enhance the inherent advantages of the APS. Adequate computation power is included to perform star identification, star tracking, attitude determination, space docking, feature tracking, descent imaging for landing control, and target tracking capabilities. Its first version uses a JPL developed 256 X 256-pixel APS and an advanced 32-bit RISC microcontroller. By taking advantage of the unique features of the APS/microcontroller combination, the microtracker will achieve about an order-of-magnitude reduction in mass and power consumption compared to present state-of-the-art star trackers. It will also add the advantage of programmability to enable it to perform a variety of star, other celestial body, and target tracking tasks. The PIM is already proving the usefulness of its design concept for space applications. It is demonstrating the effectiveness of taking such an integrated approach in building a new generation of high performance, general purpose, tracking instruments to be applied to a large variety of future space missions.

Eisenman, Allan R.; Liebe, Carl C.; Zhu, David Q.

1998-12-01

394

APS insertion devices: Magnetic performance and radiation characteristics  

SciTech Connect

There are 23 insertion devices (IDs) at the APS now, and 17 of them have been installed and commissioned. Most of the IDs are 2.4-meter-long hybrid-type undulators with a 3.3 cm period. Two wigglers are used at the APS, one of them is an elliptical multipole wiggler with an electromagnet that produces alternate horizontal magnetic fields. All APS IDs have undergone fine magnetic tuning in order to minimize various integrals of the field through the ID for the whole range of IDs gaps, including the higher-order integrated multipole moments. Measurements of the particle-beam motion as the field strength of each ID was changed throughout its range found that the closed-orbit distortion agreed well with predictions based on magnetic measurement results. Radiation from the APS undulator has been characterized in terms of absolute spectral flux. Direct measurements of the positron beam emittance have been performed. In addition, the experimentally measured brilliance tuning curves for the APS undulator have been obtained.

Gluskin, E. [Argonne National Laboratory, Advanced Photon Source, 9700 S. Cass Ave., Argonne, Illinois 60439 (United States)

1997-07-01

395

Influence of Pressing Parameters on the Microstructure of PBX 9501  

NASA Astrophysics Data System (ADS)

Microstructural features, such as defects, crystal morphology, and crystal size distribution can dramatically affect the ignition sensitivity, performance, and mechanical properties of energetic materials. While these features can be characterized for the raw material, little is known about how they are altered during pressing. For example, in the preparation of a consolidated charge of PBX 9501, variables such as ultimate pressure, number of pressing cycles, dwell time, or rest time are varied in order to achieve nominal density of 1.830 g/cc. Although this density is met, differences in pressing parameters can lead to variations in microstructure between samples. To evaluate the effect of pressing parameters on the microstructure, three cylinders of PBX 9501 have been pressed at 5 kpsi, 15 kpsi, and 30 kpsi, using a 100 Ton heated steel die press. Polarized light microscopy (PLM) images taken at 144 locations within each cylinder show differences in porosity, crystal size and size distribution between cylinders and at different locations within the same cylinder. Scanning electron microscopy (SEM) further verifies increased fracture and rubblization of HMX during pressing.

Peterson, P. D.; Mang, J. T.; Fletcher, M. A.; Olinger, B. W.; Roemer, E. L.

2004-07-01

396

The Neural Cell Adhesion Molecule Promotes Maturation of the Presynaptic Endocytotic Machinery by Switching Synaptic Vesicle Recycling from Adaptor Protein 3 (AP-3)- to AP-2-Dependent Mechanisms.  

PubMed

Newly formed synapses undergo maturation during ontogenetic development via mechanisms that remain poorly understood. We show that maturation of the presynaptic endocytotic machinery in CNS neurons requires substitution of the adaptor protein 3 (AP-3) with AP-2 at the presynaptic plasma membrane. In mature synapses, AP-2 associates with the intracellular domain of the neural cell adhesion molecule (NCAM). NCAM promotes binding of AP-2 over binding of AP-3 to presynaptic membranes, thus favoring the substitution of AP-3 for AP-2 during formation of mature synapses. The presynaptic endocytotic machinery remains immature in adult NCAM-deficient (NCAM-/-) mice accumulating AP-3 instead of AP-2 and its partner protein AP180 in synaptic membranes and vesicles. NCAM deficiency or disruption of the NCAM/AP-2 complex in wild-type (NCAM+/+) neurons by overexpression of AP-2 binding-defective mutant NCAM interferes with efficient retrieval of the synaptic vesicle v-SNARE synaptobrevin 2. Abnormalities in synaptic vesicle endocytosis and recycling may thus contribute to neurological disorders associated with mutations in NCAM. PMID:24133283

Shetty, Aparna; Sytnyk, Vladimir; Leshchyns'ka, Iryna; Puchkov, Dmytro; Haucke, Volker; Schachner, Melitta

2013-10-16

397

Renin Release  

NSDL National Science Digital Library

The aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in salt, volume, and blood pressure homeostasis of the body. Renin is mainly produced and released into circulation by the so-called juxtaglomerular epithelioid cells, located in the walls of renal afferent arterioles at the entrance of the glomerular capillary network. It has been known for a long time that renin synthesis and secretion are stimulated by the sympathetic nerves and the prostaglandins and are inhibited in negative feedback loops by angiotensin II, high blood pressure, salt, and volume overload. In contrast, the events controlling the function of renin-secreting cells at the organ and cellular level are markedly less clear and remain mysterious in certain aspects. The unravelling of these mysteries has led to new and interesting insights into the process of renin release.

2007-10-01

398

18 CFR 388.105 - Procedures for press, television, radio, and photographic coverage.  

Code of Federal Regulations, 2013 CFR

...2013-04-01 false Procedures for press, television, radio, and photographic coverage...388.105 Procedures for press, television, radio, and photographic coverage...Public Reference Room. (b) Press, television, radio and photographic coverage...

2013-04-01

399

22 CFR 9b.5 - Temporary Department of State press building passes.  

Code of Federal Regulations, 2013 CFR

...Temporary Department of State press building passes. 9b.5 Section 9b.5 Foreign...GOVERNING DEPARTMENT OF STATE PRESS BUILDING PASSES § 9b.5 Temporary Department of State press building passes. A media correspondent or...

2013-04-01

400

22 CFR 9b.4 - Department of State building press pass for technical crews.  

Code of Federal Regulations, 2013 CFR

...false Department of State building press pass for technical crews. 9b.4 Section 9b...GOVERNING DEPARTMENT OF STATE PRESS BUILDING PASSES § 9b.4 Department of State building press pass for technical crews. Department of...

2013-04-01

401

The Ex-Press Mini Glaucoma Shunt: Technique and Experience  

PubMed Central

The Ex-Press Mini Glaucoma Shunt has been available internationally for almost a decade with almost 35,000 implantations world wide. The device shunts aqueous from the anterior chamber to a subconjunctival reservoir in a similar fashion as trabeculectomy, without removal of any sclera or iris tissue. Developments in ophthalmic surgery have been focused on smaller incisions to improve patient outcomes and visual recovery. The Ex-Press is an example of these developments. This article will review the surgical technique for implanting the Ex-Press Mini Glaucoma Shunt and will highlight the clinical experience with the device.

Sarkisian, Steven R.

2009-01-01

402

EPICS Input/Output Controller (IOC) application developer`s guide. APS Release 3.12  

SciTech Connect

This document describes the core software that resides in an Input/Output Controller (IOC), one of the major components of EPICS. The basic components are: (OPI) Operator Interface; this is a UNIX based workstation which can run various EPICS tools; (IOC) Input/Output Controller; this is a VME/VXI based chassis containing a Motorola 68xxx processor, various I/O modules, and VME modules that provide access to other I/O buses such as GPIB, (LAN), Local Area Network; and this is the communication network which allows the IOCs and OPIs to communicate. Epics provides a software component, Channel Access, which provides network transparent communication between a Channel Access client and an arbitrary number of Channel Access servers.

Kraimer, M.R.

1994-11-01

403

Aerosol Polarimeter Sensor (APS) contamination control requirements and implementation  

NASA Astrophysics Data System (ADS)

The Aerosol Polarimetery Sensor (APS) is a nadir viewing, along-track observing, continuously operating electro-optical polarimeter designed to measure earth and atmosphere scene spectral radiance in the visible (VIS) to short wave infrared (SWIR) spectrum from an altitude of 705 km to permit collection of data for retrieval of operational Environmental Data Records (EDRs). APS performance can be degraded due to light scatter, transmission, or reflectance changes caused by contamination. Molecular films can cause scattering as well as spectrally selective absorption and reflectance degradation. At short wavelengths, the molecular films may also create polarization changes. Raytheon developed and implemented a contamination control program that ensured the APS sensor complied with cleanliness requirements. Representative cleanliness monitoring results and lessons learned from the sensor integrated and tested at Space and Airborne Systems El Segundo and Santa Barbara Remote Sensing (SBRS) are also presented.

Elders, Jonathan P.; Azene, Hendekea M.; Betraun, Greg T.; Wilkerson, Kerri J.

2010-08-01

404

Endothelial microparticle release is stimulated in vitro by purified IgG from patients with the antiphospholipid syndrome.  

PubMed

IgG antiphospholipid antibodies (aPL) exert direct effects on various cell types, contributing to the pathogenesis of thrombosis and pregnancy morbidity in patients with the antiphospholipid syndrome (APS). Some IgG samples from these patients activate endothelial cells (EC) in vitro as judged by surface expression of adhesion molecules such as E-selectin, which can promote thrombosis. Endothelial microparticles (EMP), which themselves are potentially prothrombotic, are released by activated EC. Though elevated circulating EMP levels have been reported in patients with APS, it is not known whether these EMP are released due to a direct effect of aPL on the cells. We tested the effect of purified polyclonal IgG from patients with APS (APS-IgG) and healthy controls (HC-IgG) upon cultured human umbilical vein EC (HUVEC). HUVEC exposed to APS-IgG produced significantly more EMP than those exposed to HC-IgG (p=0.0036) and a greater proportion of these EMP carried surface E-selectin (6.2% 4.0 for APS-IgG vs. 3.4% 2.0 for HC IgG, p=0.0172). This study therefore demonstrates that purified polyclonal APS-IgG can drive EMP release. We propose that EMP generation may be a useful measure of aPL-mediated pathogenic effects upon EC. PMID:23152159

Pericleous, Charis; Clarke, Lindsey A; Brogan, Paul A; Latchman, David S; Isenberg, David A; Ioannou, Yiannis; Giles, Ian P; Rahman, Anisur

2012-11-15

405

Piping benchmark problems for the Westinghouse AP600 Standardized Plant  

SciTech Connect

To satisfy the need for verification of the computer programs and modeling techniques that will be used to perform the final piping analyses for the Westinghouse AP600 Standardized Plant, three benchmark problems were developed. The problems are representative piping systems subjected to representative dynamic loads with solutions developed using the methods being proposed for analysis for the AP600 standard design. It will be required that the combined license licensees demonstrate that their solutions to these problems are in agreement with the benchmark problem set.

Bezler, P.; DeGrassi, G.; Braverman, J.; Wang, Y.K.

1997-01-01

406

VIEW WEST, 1ST FLOOR, EAST ROOM, HYDRAULIC COTTON PRESS, DETAIL, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW WEST, 1ST FLOOR, EAST ROOM, HYDRAULIC COTTON PRESS, DETAIL, CONTINENTAL GIN COMPANY HYDRAULIC TANK - Magnolia Plantation, Cotton Gins & Presses, LA Route 119, Natchitoches, Natchitoches Parish, LA

407

Functional analysis of the two Brassica AP3 genes involved in apetalous and stamen carpelloid phenotypes.  

PubMed

The Arabidopsis homeotic genes APETALA3 (AP3) and PISTILLATA (PI) are B genes which encode MADS-box transcription factors and specify petal and stamen identities. In the current study, the stamen carpelloid (SC) mutants, HGMS and AMS, of B. rapa and B. napus were investigated and two types of AP3 genes, B.AP3.a and B.AP3.b, were functional characterized. B.AP3.a and B.AP3.b share high similarity in amino acid sequences except for 8 residues difference located at the C-terminus. Loss of this 8 residues in B.AP3.b led to the change of PI-derived motifs. Meanwhile, B.AP3.a specified petal and stamen development, whereas B.AP3.b only specified stamen development. In B. rapa, the mutations of both genes generated the SC mutant HGMS. In B. napus that contained two B.AP3.a and two B.AP3.b, loss of the two B.AP3.a functions was the key reason for the apetalous mutation, however, the loss-of-function in all four AP3 was related to the SC mutant AMS. We inferred that the 8 residues or the PI-derived motif in AP3 gene probably relates to petal formation. PMID:21738595

Zhang, Yanfeng; Wang, Xuefang; Zhang, Wenxue; Yu, Fei; Tian, Jianhua; Li, Dianrong; Guo, Aiguang

2011-06-30

408

5. Interior, second floor. Pressed metal ceiling, and wooden floors ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. Interior, second floor. Pressed metal ceiling, and wooden floors visible. Overhead light source toward rear of building indicates location of skylight. - 25-27 East Hanover Street (Commercial Building), 25-27 East Hanover Street, Trenton, Mercer County, NJ

409

13. RADIAL DRILL, ENGINE LATHE, DRILL PRESS, AND GRINDER (L ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. RADIAL DRILL, ENGINE LATHE, DRILL PRESS, AND GRINDER (L TO R)-LOOKING SOUTHEAST. - W. A. Young & Sons Foundry & Machine Shop, On Water Street along Monongahela River, Rices Landing, Greene County, PA

410

The Push by Educators for Student Press Freedom.  

ERIC Educational Resources Information Center

Discusses the effects of the Hazelwood School District v. Kuhlmeier decision involving the First Amendment rights of high school journalists and the thrust by journalism educators to insure student press freedom. (MS)

Goodman, Mark

1988-01-01

411

Hot Isostatic Press (HIP) vitrification of radwaste concretes.  

National Technical Information Service (NTIS)

Properly formulated and properly ''canned'' radwaste concretes can be readily hot-isostatically-pressed (HIPed) into materials that exhibit performance equivalent to typical radwaste-type glasses. The HIPing conditions (temperature/pressure) required to t...

D. D. Siemer B. Scheetz M. L. D. Gougar

1995-01-01

412

5. FOURTH FLOOR, HOTEL SOAP LINES TO NORTHWEST: PRESS (LEFT ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. FOURTH FLOOR, HOTEL SOAP LINES TO NORTHWEST: PRESS (LEFT CENTER), MANUAL CUTTERS (CENTER, RIGHT CENTER) - Colgate & Company Jersey City Plant, Building No. B-15, 90-96 Greene Street, Jersey City, Hudson County, NJ

413

A Process for Producing Durable Press Fabrics Through Phosphorylation.  

National Technical Information Service (NTIS)

This invention relates to a process for producing durable press cotton-containing fabrics. More specifically it relates to the phosphorylation of cellulose with inorganic phosphorylating agents in the presence of urea.

E. J. Blanchard

1982-01-01

414

Cars & Censorship: How Advertising Pressure Can Corrupt a Free Press.  

ERIC Educational Resources Information Center

|Discusses "private censorship" as it relates to car dealers and television advertising. Defines "private censorship" as that which occurs when a broadcaster suppresses or alters a news story that affects commercial clients (advertisers). Makes recommendations for a freer press. (JOW)|

Collins, Ronald K. L.

1992-01-01

415

INTERIOR VIEW WITH CARLTON RADIAL ARM DRILL PRESS (THE CARLTON ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

INTERIOR VIEW WITH CARLTON RADIAL ARM DRILL PRESS (THE CARLTON MACHINE TOOL CO., CINCINNATI, OHIO) WITH MACHINE OPERATOR, EDDIE BURTTRAM. - O'Neal Steel, Incorporated, Fabrication Shop, 744 Forty-first Avenue North, Birmingham, Jefferson County, AL

416

Limits of applicability of the shock pressing method  

SciTech Connect

The authors estimate the critical value of the dynamic presure as a result of the cation of which the crystalline grain will disintigrtae into smaller particles, which is equivalent to the impossibility of shock pressing of powder. Despite the roughness of the assumptions made, and examination of the problem of pressing, the calculated data correctly covey the possibilities of the shock pressing method as far as can be judged from the known results. Refinement of the developed approach is possible by taking into account the lifetime of dislocations under conditions of a certain residual temperature, determined by the pressure used for pressing. However, the authors conclude that the proposed method is suitable already in the present form for rough estimates.

Batsanov, S.S.

1986-03-01

417

8. Second floor front apartment showing ornately painted pressed metal ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. Second floor front apartment showing ornately painted pressed metal ceiling, as well as modern partitions and wall treatments. View looking north. - Franklin Grocery Company Building, 1 South Main Street, Franklin, Merrimack County, NH

418

VIEW NEAR ENTRANCE, FROM NORTH, PAST WHEEL PRESS TO ROLLING ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW NEAR ENTRANCE, FROM NORTH, PAST WHEEL PRESS TO ROLLING STOCK - East Broad Top Railroad & Coal Company, Machine Shop, State Route 994, West of U.S. Route 522, Rockhill Furnace, Huntingdon County, PA

419

A parametric pressing study using a plastic-bonded explosive  

SciTech Connect

Pressed plastic-bonded explosives, PBXs, are commonly used by defense and private industry. PBX 9501 is composed of HMX crystals held together with a plastic binder 'softened' with plasticizers. The detonation behavior of any explosive is very dependent upon its density, with the desire to have a uniform, high density throughout the explosive component. A parametric study has been performed pressing PBX 9501 hydrostatically and uniaxially. The effects of several pressing parameters on the bulk density and density profile, as well as mechanical properties, have been measured. The parameters investigated include pressure, temperature, number of cycles, dwell time, rest time, sack thickness, and particle distribution and size. Density distributions within the pressed explosives were also compared.

Hayden, D. J. (David J.); Maez, L. R. (Leland R.); Olinger, B. W. (Barton W.); Powell, S. J. (Sandra J.)

2002-01-01

420

Poland's Press and Broadcasting Under the Gierek Regime  

ERIC Educational Resources Information Center

Reports that the Polish press and broadcasting have been carrying more news and less propaganda since the 1970 Baltic upheavel and that the Polish media are generally allowed more freedom than media in other Communist nations. (RB)

Shanor, Donald R.

1974-01-01

421

Articles Pertinent to the Campus Press: A Selected Annotated Bibliography  

ERIC Educational Resources Information Center

|Lists and annotates articles dealing with such topics as advertising, audience analysis, broadcasting, criticism and defense of media, editorial policy and methods, journalism history, journalism education, magazines, media management, and press law. (GW)|

Ardoin, Birthney; And Others

1978-01-01

422

Articles Pertinent to the Campus Press: A Selected Annotated Bibliography  

ERIC Educational Resources Information Center

|Lists and annotates articles dealing with such topics as advertising, audience analysis, broadcasting, broadcast law, criticism and defense of media, editorial policy and methods, media policy and methods, journalism education, press law, and school publications. (GW)|

Ardoin, Birthney; And Others

1977-01-01

423

The Push by Educators for Student Press Freedom.  

ERIC Educational Resources Information Center

|Discusses the effects of the Hazelwood School District v. Kuhlmeier decision involving the First Amendment rights of high school journalists and the thrust by journalism educators to insure student press freedom. (MS)|

Goodman, Mark

1988-01-01

424

Exploring Mars: The Ares Payload Service (APS)  

NASA Astrophysics Data System (ADS)

In last year's Mars Society convention we introduced the results of five years of studies of space launch capability for the second millennium. We concluded that Single Stage to Orbit (SSTO) vehicles such as the Delta Clipper X33, and X34 cannot make it to orbit from the Earth's surface. Whether taking off vertically or horizontally or landing vertically or horizontally, the rocket equations, the performance of available fuels, and the realities of the weight and strength of materials leave no margin for payload. The promised savings from SSTO systems are illusory. However, a configuration that is able to deliver useful payload to orbit is the Single step to Orbit, SsTO, a rocket plane that is released fully fueled, from 35,000 to 40,000 feet altitude. Three approaches have been proposed. The Hot'l and Molnya Corporation designs carry the fueled rocket plane to altitude on the back of a carrier aircraft. In this design the carrier aircraft is Russia's Antonov 225 the world's largest cargo plane. The rocket plane is a modified version of the Buran, Russia's own space shuttle. Another configuration is Kelly Aviation's concept in which the fully fueled rocket plane is towed to altitude by the cargo plane and then released. A third approach is based on the early "X" planes, which were dropped from the belly of the carrier plane. While the rocket equations indicate that these three concepts can deliver useful payloads, the Stanford review found significant advantages to the approach of Pioneer Rocket, in which the rocket plane flies up to the carrier plane with conventional jet engines, docks, and then loads on the oxidizer for the flight to orbit. This architecture has more reasonable abort modes in case of system failure in either aircraft and can deliver a larger final payload to orbit for a given sized carrier. The Stanford recommendation is that the carrier aircraft be the Antonov 225. A design based on this was presented in a report last year. Refinements to the design notably an improved re-entry cooling system and fueling stability analysis were done this year. More technical detail and a proposed international consortium to develop the SSTO is presented in another session of this year's Mars convention. We believe that there will be no human exploration of Mars based on the Shuttle or Expendable launch vehicles, and no resources available except for a cooperative international program. However, just as the world is learning to cooperate in peacekeeping, we hold out the hope that similar cooperation will develop for Mars exploration. With that in mind, this year we asked the question- "How will the human mission get to Mars if it has to use the SsTO for transportation?"

Bowen, Justin; Lusignan, Bruce

1999-08-01

425

Recrystallization of silicon nitride powders during hot pressing  

Microsoft Academic Search

The hot pressing of comminuted silicon nitride powders enables a uniform fine-grained structure of one and the same mean grain size to be obtained irrespective of the type of starting Si3N4, powder. At milling times of more than 100 h no significant decrease in particle size is observed. The recrystallization of milled silicon nitride powders during hot pressing takes place

I. I. Osipova; D. A. Pogorelovaj; V. N. Paderno; G. M. Kheidemane; T. A. Shapoval

1982-01-01

426

HOT PRESSING OF DIBORIDE REINFORCED OXIDE MATRIX COMPOSITES  

Microsoft Academic Search

Composites of particulate TiB2 in matrices of Y2o3-stabilized Zro2, Y2o3 and Al2o3 were prepared by vacuum hot pressing in graphite tooling. Results of hot pressing the oxides and the composites are presented. X-ray diffraction and scanning electron microscopy were used to characterize the materials before and after processing. The effects of processing temperature, powder size, pressure and time are emphasized.

J. Rigney; A. Abada; K. Veduia

1988-01-01

427

Microstructure and related mechanical properties of hot pressed hydroxyapatite ceramics  

Microsoft Academic Search

Polycrystalline hydroxyapatite (HAP) ceramics were densified by hot pressing. The effects of thermal treatments and of a sintering additive (Na3PO4) on the microstructure, flexural strength and fracture toughness were investigated. Hot pressing without additive resulted in dense HAP having a small average grain size (below 0.5 m). Spontaneous microcracking of the material was also noted. This originated from the thermal

R. Halouani; D. Bernache-Assolant; E. Champion; A. Ababou

1994-01-01

428

Thermomechanical finite element analysis in press-packed IGBT design  

Microsoft Academic Search

The reliability of press-packed insulated gate bipolar transistors (IGBTs) depends on satisfactory contact conditions applied at assembly stage and maintained throughout the service life. The objective of this work is the simulation of stresses and strains in press-packed IGBTs due to assembly and thermal cycling. Single-chip as well as multi-chip devices were analyzed with 2D and 3D models including an

A Pirondi; G Nicoletto; P Cova; M Pasqualetti; M Portesine

2000-01-01

429

As Fragile as a Crystal Glass: Press Freedom in Iran  

NSDL National Science Digital Library

This item from Human Rights Watch (HRW) explores the difficulties encountered by the independent reformist press in Iran in the face of determined conservative efforts to suppress it and prosecute journalists. The 21-page report also considers recent threats to the Iranian Press Law of 1985 and makes recommendations to the Government of Iran and the international community. This report is offered by chapter in HTML format.

Hicks, Elahe S.

430

Using equal-channel angular pressing for refining grain size  

Microsoft Academic Search

Equal-channel angular pressing is an effective tool for attaining ultrafine grain sizes in bulk materials. An important advantage\\u000a of this technique over conventional metalworking processes, such as extrusion and rolling, is that very high strains may be\\u000a attained without any concomitant change in the cross-sectional dimensions of the sample. The microstructures introduced by\\u000a equalchannel angular pressing critically depend on a

Terence G. Langdon; Minoru Furukawa; Minoru Nemoto; Zenji Horita

2000-01-01

431

Temperature and deformation in pressing high-temperature alloy pipe  

Microsoft Academic Search

A method for calculating the hot-pressing parameters for high-temperature alloy pipe is proposed. The method includes determination\\u000a of the temperature interval of maximum plasticity, taking account of sleeve cooling during auxiliary operations; temperature\\u000a corrections as a function of the wall thickness and sleeve temperature; the metals resistance to deformation as a function\\u000a of the pressing parameters (the pipe temperature, the

N. A. Bespalova; M. I. Medvedev; A. K. Tsarkov

2009-01-01

432

Design of a Compliant Press-Fit Pin Connection  

Microsoft Academic Search

A design method for a compliant press-fit pin connection in a plated through hole (PTH) is presented. In this connection, both compliant press-fit pin and PTH cause elastic-plastic deformation. Considering this feature, three fundamental design concepts for this connection are discussed. First, three design conditions are set: 1) the upper limit of pin insertion force to protect the copper plate

TSUNEO KANAI; YASUHIRO ANDO; SHUICHIRO INAGAKI

1985-01-01

433

Low-loss binder for hot pressing boron nitride  

DOEpatents

Borazine derivatives used as low-loss binders and precursors for making ceramic boron nitride structures. The derivative forms the same composition as the boron nitride starting material, thereby filling the voids with the same boron nitride material upon forming and hot pressing. The derivatives have a further advantage of being low in carbon thus resulting in less volatile byproduct that can result in bubble formation during pressing.

Maya, Leon (Oak Ridge, TN)

1991-01-01

434

Vesicular Release of Prolactin from Preformed Prolactin Granules Is Stimulated by Soluble Factor(s) from the Anterior Pituitary of Lactating Rats  

Microsoft Academic Search

This study demonstrates that conditioned media (CM) from the anterior pituitary gland (AP) of lactating rats contains soluble factors that promote in vitro prolactin (PRL) release from the pituitary glands of male rats. CM-induced PRL release was confirmed by polyacrylamide gel electrophoresis, ELISA and bioassay. In cultured AP cells challenged with CM, increased intracellular staining with the dye FM1-43 was

Icnelia Huerta-Ocampo; Tatiana Fiordelisio; Nestor Daz; Nilda Navarro; Alejandra Castilla; Alfonso Crabez; Manuel B. Aguilar; Teresa Morales; Arturo Hernndez-Cruz; Flavio Mena

2007-01-01

435

Action potential bursts enhance transmitter release at a giant central synapse  

PubMed Central

Abstract Patterns of action potentials (APs), often in the form of bursts, are critical for coding and processing information in the brain. However, how AP bursts modulate secretion at synapses remains elusive. Here, using the calyx of Held synapse as a model we compared synaptic release evoked by AP patterns with a different number of bursts while the total number of APs and frequency were fixed. The ratio of total release produced by multiple bursts to that by a single burst was defined as burst-effect. We found that four bursts of 25 stimuli at 100 Hz increased the total charge of EPSCs to 1.47 0.04 times that by a single burst of 100 stimuli at the same frequency. Blocking AMPA receptor desensitization and saturation did not alter the burst-effect, indicating that it was mainly determined by presynaptic mechanisms. Simultaneous dual recordings of presynaptic membrane capacitance (Cm) and EPSCs revealed a similar burst-effect, being 1.58 0.13 by Cm and 1.49 0.05 by EPSCs. Reducing presynaptic Ca2+ influx by lowering extracellular Ca2+ concentration or buffering residual intracellular Ca2+ with EGTA inhibited the burst-effect. We further developed a computational model largely recapitulating the burst-effect and demonstrated that this effect is highly sensitive to dynamic change in availability of the releasable pool of synaptic vesicles during various patterns of activities. Taken together, we conclude that AP bursts modulate synaptic output mainly through intricate interaction between depletion and replenishment of the large releasable pool. This burst-effect differs from the somatic burst-effect previously described from adrenal chromaffin cells, which substantially depends on activity-induced accumulation of Ca2+ to facilitate release of a limited number of vesicles in the releasable pool. Hence, AP bursts may play an important role in dynamically regulating synaptic strength and fidelity during intense neuronal activity at central synapses.

Zhang, Bo; Sun, Liang; Yang, Yi-Mei; Huang, Hong-Ping; Zhu, Fei-Peng; Wang, Li; Zhang, Xiao-Yu; Guo, Shu; Zuo, Pan-Li; Zhang, Claire X; Ding, Jiu-Ping; Wang, Lu-Yang; Zhou, Zhuan

2011-01-01

436

The Relationship between AP[R] Exam Performance and College Outcomes. Research Report No. 2009-4  

ERIC Educational Resources Information Center

|This study focused on the relationship between students' Advanced Placement Program[R] (AP[R]) performance in AP English Language, Biology, Calculus, and U.S. History, and their subsequent college success. For each AP Exam studied, students were divided into three groups according to their AP Exam performance (no AP Exam taken, score of 1 or 2,

Mattern, Krista D.; Shaw, Emily J.; Xiong, Xinhui

2009-01-01

437

Nuclear Reactor Safety--The APS Submits its Report  

ERIC Educational Resources Information Center

|Presents the summary section of the American Physical Society (APS) report on the safety features of the light-water reactor, reviews the design, construction, and operation of a reactor and outlines the primary engineered safety features. Summarizes the major recommendations of the study group. (GS)|

Physics Today, 1975

1975-01-01

438

Tank 241AP104 Grab Sampling and Analysis Plan  

SciTech Connect

This sampling and analysis plan (SAP) identifies characterization objectives pertaining to sample collection, laboratory analytical evaluation, and reporting requirements for samples obtained from tank 241-AP-104. The purpose of this sampling event is to obtain information about the characteristics of the contents of 241-AP-104 required to provide sample material to the Waste Treatment Contractor. Grab samples will be obtained from riser 001 to provide sufficient material for the chemical analyses and tests required to satisfy these data quality objectives and ICD-23. The 222-S Laboratory will receive samples; composite the samples; perform chemical analyses on composite samples; and provide samples to the Waste Treatment Contractor and the Process Chemistry Laboratory. The Process Chemistry Laboratory at the 222-S Laboratory Complex will perform process tests to evaluate the behavior of the 241-AP-104 waste undergoing the retrieval and treatment scenarios defined in the applicable DQOs. The Waste Treatment Contractor will perform process verification and waste form qualification tests. Requirements for analyses of samples originating in the L & H DQO process tests will be documented in the corresponding test plan (Person 2000) and are not within the scope of this SAP. This report provides the general methodology and procedures to be used in the preparation, retrieval, transport, analysis, and reporting of results from grab samples retrieved from tank 241-AP-104.

TEMPLETON, A.M.

2000-11-09

439

A process definition repository based on step AP 213  

SciTech Connect

Over the years, in the context of numerically controlled machined part manufacturing, the loss, misinterpretation, and redundancy of re-inputting manufacturing instructions and data during the evolution of a product design into the finished product has been a resource depleting and costly endeavor. It is the intent of this project to utilize the emerging standards from the International Standards Organization, ISO 10303 Standard for the Exchange of Product Model Data, commonly referred to as STEP, to store and retrieve process planning information for a set of production work instructions. The project focuses on the utilization of the 1995 version of the Draft International Standard ISO/DIS 10303-213:1995 (E) Application protocol: Numerical control process plans for machined parts (AP213). This project illustrates the methodologies used to build an object-oriented Process Definition Repository (PDR), describes both the benefits and shortcomings experienced in implementing AP213, and recommends enhancements to AP213 for process planning information. The deliverable will be a Part 21 data file, based on the application-interpreted model for AP213 and integrated with product design data.

Butler, J.W.

1997-09-01

440

Tank 241AP102 Vapor Sampling and Analysis Plan  

Microsoft Academic Search

This tank sampling and analysis plan (SAP) identifies characterization objectives pertaining to sample collection, laboratory analytical evaluation, and reporting requirements for vapor samples from the head space of tank 241-AP-102. Sampling will be performed in accordance with ''Data Quality Objectives for Regulatory Requirements for Hazardous and Radioactive Air Emissions Sampling and Analysis'' (Air DQO) (Mulkey 1999). The sample results will

2001-01-01

441

A Highly Flexible Bunch Compressor for the APS LEUTL FEL  

Microsoft Academic Search

The LEUTL FEL at the APS has achieved gain at 530 nm with peak beam current \\\\~100 A. In an effort to push to 120 nm and beyond, we have designed and are commissioning a bunch compressor to increase the peak current to 600 A or more. The bunch compressor uses a four-dipole chicane at an energy of 100 to

Michael Borland; John Lewellen; Steve Milton

2000-01-01

442

Flexible and telescopic vacuum chambers for the APS bunch compressor  

Microsoft Academic Search

The Advanced Photon Source (APS) bunch compressor was built with the goal of producing electron bunches with high peak current. Vacuum chamber liners were designed to, reduce the interaction of the electron beam with the surrounding chamber walls. The goal was to have the field of the beam encountering chamber walls that are smooth having diametrical changes that are well

D. R. Walters; L. H. Morrison

2001-01-01

443

Validating Placement Rules for the APS Reading Test.  

ERIC Educational Resources Information Center

A study was conducted to determine how best to use APS Reading Test scores for making English placement recommendations for students at College of the Canyons (COC) in Santa Clarita, California. The primary method used to establish cut scores involves comparing success rates for contrasting groups over a range of scores. The contrasting groups are

College of the Canyons, Santa Clarita, CA.

444

An ancillary pumping system for the APS vacuum system  

Microsoft Academic Search

An ancillary pumping system has been designed and installed in the Advanced Photon Source (APS) storage ring. This vacuum system has the ability to pump sectors of the storage ring down from room pressure to ultra-high vacuum (UHV). The ancillary system is a dry system that uses a combination of turbomolecular pumps and oil-free roughing pumps. The benefits of this

D. Walters; J. Noonan; J. Gagliano; G. Harris; V. Svirtun

1997-01-01

445

Ancillary pumping system for the APS vacuum system.  

National Technical Information Service (NTIS)

An ancillary pumping system has been designed and installed in the Advanced Photon Source (APS) storage ring. This vacuum system has the ability to pump sectors of the storage ring down from room pressure to ultra-high vacuum (UHV). The ancillary system i...

D. Walters J. Noonan J. Gagliano

1997-01-01

446

Modelling the light variability of the Ap star ? Ursae Majoris  

Microsoft Academic Search

Aims: We simulate the light variability of the Ap star ? UMa using the observed surface distributions of Fe, Cr, Ca, Mn, Mg, Sr, and Ti obtained with the help of the Doppler imaging technique. Methods: Using all photometric data available, we specified light variations of ? UMa modulated by its rotation from far UV to IR. We employed the

D. Shulyak; J. Krticka; Z. Mikulsek; O. Kochukhov; T. Lftinger

2010-01-01

447

Coupled-bunch instabilities in the APS ring.  

National Technical Information Service (NTIS)

A study of coupled bunch instabilities for the APS storage ring is presented. The instabilities are driven by the higher-order modes of the fifteen 352-MHz single-cell RF cavities. These modes are modeled using the 2-D cavity program URMEL. The program ZA...

L. Emery

1991-01-01

448

75 FR 75666 - Advanced Placement (AP) Test Fee Program  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF EDUCATION [CFDA No. 84.330B] Advanced Placement (AP) Test Fee Program AGENCY: Office of Elementary and Secondary...Electronic Access to This Document: You can view this document, as well as all other documents of this Department published in...

2010-12-06

449

AP-1 Binding Transcriptionally Regulates Human Neutral Ceramidase  

PubMed Central

Many forms of cellular stress cause an elevation of endogenous ceramide levels leading to growth arrest or apoptosis. Ceramidases (CDase) play a critical role in regulating apoptosis by hydrolyzing ceramide into sphingosine, a precursor for promitogenic sphingosine-1-phosphate. Growth factor induction of neutral CDase (nCDase) has been shown to have a cytoprotective effect against cytokine-induced increases in ceramide levels. To further define the physiological regulation of nCDase, we identified a 200 bp promoter region and demonstrated that serum activated this proximal promoter, which correlated with a serum-induced increase in human nCDase mRNA expression. Computational analysis revealed a putative cis-element for AP-1, a transcription factor activated by serum. Electrophoretic mobility shift assays demonstrated that the identified transcriptional response element binds to AP-1 transcription factors. RNA interference-mediated knockdown of the AP-1 subunit, c-Jun, inhibited the activity of the human nCDase proximal promoter, whereas, c-Jun overexpression increased promoter activity, which directly correlated with human nCDase mRNA transcription, decreased ceramide mass, and protection against caspase 3/7-dependent apoptosis. Taken together, our findings suggest that c-Jun/AP-1 signaling may, in part, regulate serum-induced human nCDase gene transcription.

O'Neill, Sean M.; Houck, Kristy L.; Yun, Jong K.; Fox, Todd E.; Kester, Mark

2013-01-01

450

High-brightness beam diagnostics for the APS linac  

Microsoft Academic Search

The Advanced Photon Source (APS) injector includes an S-band linac with the capability to accelerate beams to 650 MeV. The linac has recently been upgraded with the installation of an RF thermionic gun in addition to the standard DC thermionic gun. The RF gun is predicted to have lower emittance (5 ? mm mrad) and may be used to support

A. H. Lumpkin; B. X. Yang; W. J. Berg; J. W. Lewellen; S. V. Milton

1999-01-01

451

The Delta 125 Steam Generator Design for the AP1000  

Microsoft Academic Search

The Advanced Plant 1000 uses two Delta 125 steam generators, with each steam generator rated at 1707.5 MWt. The AP1000 Delta 125 steam generator design has many features that represent 'best practices' with respect to steam generator design and reliability and long-term performance. These features are summarized in this paper. (authors)

Robert F. Condrac; Remco P. Waszink; Christopher G. Pankiewicz-Nohr

2004-01-01

452

Fuel Cell Application Problems: Study Guide for AP Chemistry  

NSDL National Science Digital Library

This study guide is intended for 10th-12th grade AP chemistry students studying fuel cell technology. Applicable National Science Education Standards are included in the document. The study guide includes a comparison of gasoline and hydrogen, a section on kinetic molecular theory, a section on electrochemistry and material on hydrogen fuel cells. This document may be downloaded in PDF file format.

Cox, Brian A.

2012-07-31

453

APS storage ring vacuum chamber: Section 1, Evaluation  

SciTech Connect

The vacuum characteristics of the APS storage ring vacuum chamber prototype, Section One (S1), is presented. The base pressure achieved was 4 {times} 10{sup {minus}11}, the welds contained no virtual or real leaks, the NeG strip mounting design and activation procedures have been determined, and S1 was found contaminated with hydrocarbons.

Benaroya, R.; Roop, B.

1995-07-01

454

Arbitrary function generator for APS injector synchrotron correction magnets.  

National Technical Information Service (NTIS)

The APS injector synchrotron ring measures about 368 m in circumference. In order to obtain the precision of the magnetic field required for the positron acceleration from 450 Mev to 7.7 Gev with low beam loss, eighty correction magnets are distributed ar...

O. D. Despe

1990-01-01

455

Accretion of interplanetary dust by Ap and Am stars  

SciTech Connect

Accretion of interplanetary dust and comets by A-type stars is investigated to see whether this process can explain the overabundances of heavy elements in Ap and Am stars. The dust particles spiral in by the Poynting-Robertson effect and evaporate above the star. This process is evaluated by considering the evolution of silicate and graphite particles in the radiation field of Alpha Leo (B7 V). It is found that graphite particles evaporate above 20 stellar radii and silicate dust grains above 50 stellar radii. The evaporated atoms will be quickly ionized. In the case of Am stars the ions will wander off and not reach the photosphere, but in the case of Ap stars they can be trapped by the magnetic field of the star and reach the surface. The magnetosphere of a typical Ap star is modeled, and the fate of the ions is studied. The efficiency of accretion from the magnetosphere is sensitive to the presence of any plasma in the magnetosphere. The comet impact process is found capable of producing the abundance anomalies in Ap as well as Am stars, assuming that the comet impact rate is 0.03/yr, nearly the same as in the solar system. 35 references.

Kumar, C.K.; Davila, J.M.; Rajan, R.S. (Howard Univ., Washington, DC (USA); NASA, Goddard Space Flight Center, Greenbelt, MD (USA); California Institute of Technology, Pasadena (USA))

1989-02-01

456

The APS Panel on Public Affairs and Federal Science Policy  

NASA Astrophysics Data System (ADS)

The Panel on Public Affairs (POPA) is the organ through which the APS seeks to provide high quality input to the Federal Government on issues with significant physics content, ranging from energy and environment to national security. I will describe POPA's evolving mission, some recent efforts and successes, and look at the agenda for the next few years.

Jaffe, Robert

2013-03-01

457

AP Biology Workshop: The Importance of Laboratory Work  

NSDL National Science Digital Library

This is a collection of essays that highlights the benefits of conducting lab experiments as part of the AP Biology curriculum. It encourages teachers to continue using learning tools like technology in lab experiments to enhance the classroom experience for students.

The College Board The College Board (The College Board;); Carolyn Schofield (The College Board;)

2012-10-24

458

AP: A Critical Examination of the Advanced Placement Program  

ERIC Educational Resources Information Center

|With an annual yearly growth rate of 9.3 percent over the last two decades, Advanced Placement courses have become a juggernaut in American high school education. AP courses are routinely perceived as an indicator of educational rigor, and many schools push to enroll low-income or minority students in these courses in the hope of preparing them

Sadler, Philip M., Ed.; Sonnert, Gerhard, Ed.; Tai, Robert H., Ed.; Klopfenstein, Kristin, Ed.

2010-01-01

459

[The Roentgen's discovery -first press releases, research articles and textbooks in Krakw].  

PubMed

The author presents Krakw's publications from the pioneering years of radiology. She also emphasises the great role of the publications in the development of this field in Krakw's medical environment PMID:23944112

Urbanik, Monika

2013-01-01

460

Waste treatment: analysis of media communications (press releases between 10/95 and 03/96).  

National Technical Information Service (NTIS)

In the framework of a national media communication survey concerning the waste treatment sector, a status report has been realized in order to help develop communication strategies. The study was based on a corpus composed of 1250 articles related to wast...

F. Chantar C. Legris-Desfortes

1996-01-01

461

Functional demands of statistical literacy: Ability to read press releases from statistical agencies  

Microsoft Academic Search

ability to comprehend, interpret, and critically evaluate messages with statistical elements or arguments (Gal, 2002). Statistical literacy has been positioned as an important skill for citizens and a desired outcome of statistics education (Wallman, 1993). However, while the knowledge bases and beliefs and attitudes that underlie statistically literate behavior have been outlined in some detail, it is less clear how

Iddo Gal

462

A Bayesian Hierarchical Topic Model for Political Texts: Measuring Expressed Agendas in Senate Press Releases  

Microsoft Academic Search

Political scientists lack methods to efficiently measure the priorities political actors emphasize in statements. To address this limitation, I introduce a statistical model that attends to the structure of political rhetoric when measuring expressed priorities: statements are naturally organized by author. The expressed agenda model exploits this structure to simultaneously estimate the topics in the texts, as well as the

Justin Grimmer

2010-01-01

463

Automatic Extraction of Facts from Press Releases to Generate News Stories  

Microsoft Academic Search

While complete understanding of arbitrary input text remains in the future, it is currently possible to construct natural language processing systems that provide a partial understanding of text with limited accuracy. Moreover, such systems can provide cost-effective solutions to commercially-significant business problems. This paper describes one such system: JASPER. JASPER is a fact extraction system recently developed and deployed by

Peggy M. Andersen; Philip J. Hayes; Steven P. Weinstein; Alison K. Huettner; Linda M. Schmandt; Irene B. Nirenburg

1992-01-01

464

Learning the Genre of the Press Release: Developmental Processes in Adult Writers.  

ERIC Educational Resources Information Center

During a year-long ethnography in a workplace setting (a non-profit job and literacy training agency), a study examined how managers learned new genres required in their jobs. There were 2 research questions: (1) what are the specific aspects of a genre to be mastered for effective written communication? and (2) what is the developmental process

Beaufort, Anne

465

Analysis of AP-1 function in cellular transformation pathways.  

PubMed Central

To understand the role of endogenous AP-1 activity in cellular transformation induced by oncogenes, we have made use of a fos mutant (supfos-1) and a jun mutant (supjun-1), either of which can function as a transdominant inhibitor of AP-1-mediated transcriptional regulation. Chicken embryo fibroblasts (CEF) infected with a series of transforming retroviruses were doubly infected with retrovirus carrying supfos-1 or supjun-1, and suppression of cellular transformation was monitored in terms of reversion to normal cellular morphology or acquisition of anchorage-dependent growth. Cellular transformation induced by several exogenously expressed transforming genes of the fos or jun family was efficiently suppressed, as expected. CEF transformed by v-src, v-yes, v-fps, c-Ha-ras, and N-terminally truncated c-raf were also induced to revert to the normal phenotype by these transdominant mutants, suggesting that functional transcription factor AP-1 activity is essential for the cellular transformation induced by these oncogenes. The suppression is not attributable to nonspecific inhibition of cellular proliferation, because CEF transformed by v-ros or v-myc were not induced to revert to the normal phenotype. We next analyzed changes in all known components of chicken AP-1 induced by v-src, c-Ha-ras, or activated c-raf transformation. The levels of both Fra-2 and c-Jun expression were elevated two- to fourfold, and hyperphosphorylation of Fra-2 was also observed. We further showed that Fra-2-c-Jun heterodimer is mainly responsible for the elevated AP-1 DNA-binding activity in these transformed cells, and we propose that this heterodimer play a crucial role in the transformation induced by these oncogenes. Images

Suzuki, T; Murakami, M; Onai, N; Fukuda, E; Hashimoto, Y; Sonobe, M H; Kameda, T; Ichinose, M; Miki, K; Iba, H

1994-01-01

466

APS beamline standard components handbook. Version 1.1  

SciTech Connect

It is clear that most Advanced Photon Source (APS) Collaborative Access Team (CAT) members would like to concentrate on designing specialized equipment related to their scientific programs rather than on routine or standard beamline components. Thus, an effort is in progress at the APS to identify standard and modular components of APS beamlines. Identifying standard components is a nontrivial task because these components should support diverse beamline objectives. To assist with this effort, the APS has obtained advice and help from a Beamline Standardization and Modularization Committee consisting of experts in beamline design, construction, and operation. The staff of the Experimental Facilities Division identified various components thought to be standard items for beamlines, regardless of the specific scientific objective of a particular beamline. A generic beamline layout formed the basis for this identification. This layout is based on a double-crystal monochromator as the first optical element, with the possibility of other elements to follow. Pre-engineering designs were then made of the identified standard components. The Beamline Standardization and Modularization Committee has reviewed these designs and provided very useful input regarding the specifications of these components. We realize that there will be other configurations that may require special or modified components. This Handbook in its current version (1.1) contains descriptions, specifications, and pre-engineering design drawings of these standard components. In the future, the APS plans to add engineering drawings of identified standard beamline components. Use of standard components should result in major cost reductions for CATs in the areas of beamline design and construction.

Kuzay, T.M.

1992-01-01

467

77 FR 24480 - Application for New Awards; Advanced Placement (AP) Test Fee Program-Reopening the AP Test Fee...  

Federal Register 2010, 2011, 2012, 2013

...Application for New Awards; Advanced Placement (AP) Test Fee Program...pay up to $38 per advanced placement exam for up to three exams...full cost of each advanced placement exam, with no limitation on...can view this document, as well as all other documents of...

2012-04-24

468

Preliminary calculations on the determination of APS particle-beam parameters based on undulator radiation.  

National Technical Information Service (NTIS)

The potential measurement of particle beam emittance at a third-generation synchrotron radiation facility such as the Advanced Photon Source (APS) by characterizing the observed undulator radiation from an insertion device is considered. The nominal APS p...

A. Lumpkin B. Yang Y. Chung R. Dejus G. Voykov

1995-01-01

469

APS Presents Awards for the Best Physiology Project at Local Summer Science Camp  

NSDL National Science Digital Library

This article is on page 174-175 of The Physiologist, October 2012. APS members continue to judge and present Science Fair Awards on behalf of the APS at local and regional science fairs for precollege students across the nation.

APS Education Office (American Physiological Society Education Office)

2012-10-01

470

Protests Against the Vietnam War in 1960s Britain: The Relationship between Protesters and the Press  

Microsoft Academic Search

Previous attempts to understand press coverage of protests against the Vietnam War have either emphasized the struggle for self-definition that protesters were confronted with as a result of a dominant press presentation or have noted the press reversion to long-established models to explain this new phenomenon. In turn protesters were usually hostile to the press both because they felt they

Nick Thomas

2008-01-01

471

The process of grain refinement in equal-channel angular pressing  

Microsoft Academic Search

Experiments were conducted on high purity aluminum to investigate the process of grain refinement during equal-channel angular (ECA) pressing. Samples were subjected to 1 to 4 pressings and then sectioned for microstructural examination in three mutually perpendicular directions. The results show that a single pressing leads to the development of subgrain bands. The subsequent microstructural development in additional pressings depends

Yoshinori Iwahashi; Zenji Horita; Minoru Nemoto; Terence G Langdon

1998-01-01

472

An Update of Freedom of the Press and Information in Latin America and the Caribbean.  

ERIC Educational Resources Information Center

This paper is based on a review of the literature that included reports from the Inter-American Press Association's general assembly in Los Angeles in October 1984, the mid-year meeting of the Inter-American Press Association in Panama City in March 1985, and the 1983 world press freedom review of the International Press Institute. Other material

Garrison, Bruce; Munoz, Julio E.

473

An Update of Freedom of the Press and Information in Latin America and the Caribbean.  

ERIC Educational Resources Information Center

|This paper is based on a review of the literature that included reports from the Inter-American Press Association's general assembly in Los Angeles in October 1984, the mid-year meeting of the Inter-American Press Association in Panama City in March 1985, and the 1983 world press freedom review of the International Press Institute. Other material

Garrison, Bruce; Munoz, Julio E.

474

The AP3 Adaptor Complex Is Essential for Cargo-Selective Transport to the Yeast Vacuole  

Microsoft Academic Search

Three distinct adaptor protein (AP) complexes involved in protein trafficking have been identified. AP-1 and AP-2 mediate protein sorting at the trans-Golgi network and plasma membrane, respectively, whereas the function of AP-3 has not been defined. A screen for factors specifically involved in transport of alkaline phosphatase (ALP) from the Golgi to the vacuole\\/lysosome has identified Apl6p and Apl5p of

Christopher R Cowles; Greg Odorizzi; Gregory S Payne; Scott D Emr

1997-01-01

475

Role of active site tyrosines in dynamic aspects of DNA binding by AP endonuclease  

Microsoft Academic Search

AP endonuclease (AP endo), a key enzyme in repair of abasic sites in DNA, makes a single nick 5? to the phosphodeoxyribose of an abasic site (AP-site). We recently proposed a novel mechanism, whereby the enzyme uses a key tyrosine (Tyr171) to directly attack the scissile phosphate of the AP-site. We showed that loss of the tyrosyl hydroxyl from Tyr171

Luisa F. Melo; Sophia T. Mundle; Michael H. Fattal; N. Edel ORegan; Phyllis R. Strauss

2007-01-01

476

The Assembly of AP3 Adaptor Complex-containing Clathrin-coated Vesicles on Synthetic Liposomes  

Microsoft Academic Search

The heterotetrameric adaptor protein complex AP-3 has been shown to function in the sorting of proteins to the endosomal\\/lysosomal system. However, the mechanism of AP-3 recruitment onto membranes is poorly understood, and it is still uncertain whether AP-3 nucleates clathrin-coated vesicles. Using purified components, we show that AP-3 and clathrin are recruited onto protein- free liposomes and Golgi-enriched membranes by

Matthew T. Drake; Yunxiang Zhu; Stuart Kornfeld

477

AP4 directly downregulates p16 and p21 to suppress senescence and mediate transformation  

PubMed Central

Here we analyzed the function of the c-MYC-inducible basic helixloophelix leucine-zipper transcription factor AP4 in AP4-deficient mouse embryo fibroblasts (MEFs). Loss of AP4 resulted in premature senescence and resistance towards immortalization. Senescence was accompanied by induction of the cyclin-dependent kinase inhibitor-encoding genes p16, a known tumor suppressor, and p21, a previously described target for repression by AP4. Notably, AP4 directly repressed p16 expression via conserved E-box motifs in MEFs and human diploid fibroblasts. Senescence caused by AP4-deficiency was prevented by depletion of p16 and/or p21, demonstrating that these factors mediate senescence caused by AP4 loss. As senescence induced by the loss of AP4 was rescued by ectopic AP4, secondary lesions were not involved in causing premature senescence. Activation of c-MYC resulted in repression of p21 and p16 in AP4+/+, but not in AP4?/? MEFs. Furthermore, after combined expression of c-MYC and mutant RAS in MEFs, AP4 was required for colony formation, anchorage-independent growth and tumor formation in mice. In addition, combined ectopic expression of AP4 and mutant RAS in MEFs resulted in colony formation. However, additional loss of the p53 tumor suppressor was necessary for anchorage-independent growth and tumor formation of MEFs by combined AP4 and mutant RAS expression. In conclusion, this study identified AP4 as an oncogenic antagonist of cellular senescence. AP4 achieves this effect by direct repression of p16 and p21, and may thereby critically contribute to c-MYC function and tumor progression.

Jackstadt, R; Jung, P; Hermeking, H

2013-01-01

478

Quality parameters for cold pressed edible argan oils.  

PubMed

Argan oil belongs to the high-price vegetable oils on the market. Therefore, consumers have the right to purchase a high-quality product. The quality of edible vegetable oils is defined in food standards in which sensory quality is the most important feature. Additional parameters are defined to assess the identity of oils or to evaluate their oxidative state. The sensory quality of cold pressed argan oil is altered if the production has not been performed with reasonable care regarding raw material and extraction. Only oil from roasted seeds extracted by a screw-press had a sufficient sensory quality over a period of 20 weeks without unacceptable sensory attributes. Under accelerated storage conditions oil from roasted seeds extracted by a screw-press remained below the limits given by the Codex Alimentarius or the German guideline for Edible Fats and Oils for peroxide and totox value. Oil from unroasted seeds or oil from goat-digested roasted seeds and extracted by a screw-press, as well as oil from roasted seeds traditionally extracted, exceeded these limits. Initial oxidative stability of oil from unroasted seeds was significantly lower than that of the other oils. After 35 days under accelerated storage, oil from roasted seeds obtained using a screw-press showed the highest oxidative stability. Moreover, tocopherol and phytosterol compositions are useful features of argan oil. PMID:23472455

Matthus, Bertrand

2013-01-01

479

Crystal structures of eosinophil-derived neurotoxin (EDN) in complex with the inhibitors 5'-ATP, Ap3A, Ap4A, and Ap5A.  

PubMed

Eosinophil-derived neurotoxin (EDN) is a catalytically proficient member of the pancreatic ribonuclease superfamily secreted along with other eosinophil granule proteins during innate host defense responses and various eosinophil-related inflammatory and allergic diseases. The ribonucleolytic activity of EDN is central to its antiviral and neurotoxic activities and possibly to other facets of its biological activity. To probe the importance of this enzymatic activity further, specific inhibitors will be of great aid. Derivatives of 5'-ADP are among the most potent inhibitors currently known. Here, we use X-ray crystallography to investigate the binding of four natural nucleotides containing this moiety. 5'-ATP binds in two alternative orientations, one occupying the B2 subsite in a conventional manner and one being a retro orientation with no ordered adenosine moiety. Diadenosine triphosphate (Ap3A) and diadenosine tetraphosphate (Ap4A) bind with one adenine positioned at the B2 subsite, the polyphosphate chain extending across the P1 subsite in an ill-defined conformation, and a disordered second adenosine moiety. Diadenosine pentaphosphate (Ap5A), the most avid inhibitor of this series, binds in a completely ordered fashion with one adenine positioned conventionally at the B2 subsite, the polyphosphate chain occupying the P1 and putative P(-1) subsites, and the other adenine bound in a retro-like manner at the edge of the B1 subsite. The binding mode of each of these inhibitors has features seen in previously determined structures of adenosine diphosphates. We examine the structure-affinity relationships of these inhibitors and discuss the implications for the design of improved inhibitors. PMID:16401072

Baker, Matthew D; Holloway, Daniel E; Swaminathan, G Jawahar; Acharya, K Ravi

2006-01-17

480

Assembly and function of AP3 complexes in cells expressing mutant subunits  

Microsoft Academic Search

he mouse mutants mocha and pearl are deficient in the AP-3 ? and ? 3A subunits, respectively. We have used cells from these mice to investigate both the assembly of AP-3 complexes and AP-3 function. In mocha cells, the ? 3 and ? 3 subunits coassemble into a heterodimer, whereas the ? 3 subunit remains monomeric. In pearl cells, theand

Andrew A. Peden; Rachel E. Rudge; Winnie W. Y. Lui; Margaret S. Robinson

2002-01-01

481

APS: 125 Years of Progress of Physiology as a Scientific Discipline and a Profession  

ERIC Educational Resources Information Center

|The Experimental Biology 2012 meeting in San Diego, CA, included events to celebrate the 125th anniversary of the founding of the American Physiological Society (APS) and reflect on the recent accomplishments of the society. Most of the APS activities in the past quarter century were guided by a series of strategic plans. Membership in the APS

Carroll, Robert G.; Frank, Martin; Ra'anan, Alice; Matyas, Marsha L.

2013-01-01

482

Diadenosine polyphosphates (Ap3A and Ap4A) behave as alarmones triggering the synthesis of enzymes of the phenylpropanoid pathway in Arabidopsis thaliana  

PubMed Central

It is known that cells under stress accumulate various dinucleoside polyphosphates, compounds suggested to function as alarmones. In plants, the phenylpropanoid pathways yield metabolites protecting these organisms against various types of stress. Observations reported in this communication link these two phenomena and provide an example of a metabolic addressee for an alarm signaled by diadenosine triphosphate (Ap3A) or diadenosine tetraphosphate (Ap4A). In response to added Ap3A or Ap4A, seedlings of Arabidopsis thaliana incubated in full nutrition medium increased both the expression of the genes for and the specific activity of phenylalanine ammonia-lyase and 4-coumarate:coenzyme A ligase, enzymes that control the beginning of the phenylpropanoid pathway. Neither adenine mononucleotides (AMP, ADP or ATP) nor adenosine evoked such effects. Reactions catalyzed in vitro by these enzymes were not affected by Ap3A or Ap4A.

Pietrowska-Borek, Malgorzata; Nuc, Katarzyna; Zielezinska, Malgorzata; Guranowski, Andrzej

2011-01-01

483

Muscarinic Regulation of Basal versus Thyrotropin-Releasing Hormone-Induced Prolactin Secretion in Rat AnteriorPituitary Cells  

Microsoft Academic Search

Acetylcholine (ACh), synthesized in the pituitary, can act locally to modulate pituitary function. We used rat primary anterior pituitary (AP) cells to investigate how ACh affects pituitary prolactin (PRL) secretion in the presence or absence of known PRL regulators: thyrotropin-releasing hormone (TRH), 17?-estradiol (E2) and triiodothyronine (T3). Cultured AP cells were prepared from ovariectomized rats and pretreated with diluent, 0.6

Hsiao-Fung Pu; Sai-Koong Tan; Hsing-Liang Chen; Jing-Chi Jea; Tsuei-Chu Liu

1999-01-01

484

Influence of moisture content and cooking on screw pressing of crambe seed  

Microsoft Academic Search

The cooking and drying conditions for oilseeds preparatory to screw pressing are some of the most important factors that influence\\u000a screw-press performance. Screw-press oil recovery, residual oil, pressing rate, and oil sediment content were measured for\\u000a uncooked crambe seed and crambe seed cooked at 100C for 10 min, pressed at six moisture contents ranging from 9.2 to 3.6%\\u000a dry basis.

K. K. Singh; D. P. Wiesenborn; K. Tostenson; N. Kangas

2002-01-01

485

Mechanism of grain orientation during hot-pressing of bismuth titanate  

Microsoft Academic Search

Grain-oriented BiTiO ceramics have been prepared by hot-pressing. Platelike grains align during hot-pressing; the long-axis direction perpendicular to the crystal c axis is oriented perpendicular to the pressing direction. The authors describe the effects of hot-pressing conditions such as temperature, pressure, time, and type of filler on the density, orientation degree, and deformation of hot-pressed compacts. Sharp increases in the

Toshio Kimura; Takeshi Yoshimoto; Nobuyoshi Iida; Yoshiaki Fujita; Takashi Yamaguchi

1989-01-01

486

Pew Research Center for the People and the Press: News Audiences Increasingly Politicized  

NSDL National Science Digital Library

The Pew Research Center for the People and the Press serves as "an independent opinion research group that studies attitudes toward the press, politics and public policy issues." As such, the center frequently release various reports on a host of topics, such as those on public attitudes about the credibility and salience of the news media and in-depth surveys and analyses of the public and opinion leaders on international policy. One of the more recent reports is this 106-page document examining a number of trends, including where Americans go to find out about the news, online news readership, and the declining credibility in various media organizations. This report is based on a nationwide poll of 3000 adults, conducted over April and May of 2004, and contains a number of findings, including the fact that more and more Americans are watching Fox News on a regular basis. The report is divided into six primary sections and also includes the questionnaires on which the report is based.

487

Press, Regime and Society in Jordan Since 1989  

NSDL National Science Digital Library

Originally published in 1998 in the Occasional Paper series of the Inter-University Consortium for Arab Studies, Montreal, this paper by doctoral candidate Adam Jones offers a rare scholarly glimpse into recent press-regime relations in Jordan. Winner of the University of British Columbia Political Science Association Essay Prize (Ph.D. division), this paper seeks to place post-1989 events in Jordan in their historical, regional, and cultural context. "Based in part on interviews with key figures in the Jordanian press and government, it considers the complex interaction among press, regime, and society during the 1990s. A postscript appraises the situation in light of the regime's crackdown of September 1997."

Jones, Adam (Adam Jason), 1963-.

1998-01-01

488

Asynchronous decision making in a memorized paddle pressing task.  

PubMed

This paper presents a method for asynchronous decision making using recorded neural data in a binary decision task. This is a demonstration of a technique for developing motor cortical neural prosthetics that do not rely on external cued timing information. The system presented in this paper uses support vector machines and leaky integrate-and-fire elements to predict directional paddle presses. In addition to the traditional metrics of accuracy, asynchronous systems must also optimize the time needed to make a decision. The system presented is able to predict paddle presses with a median accuracy of 88% and all decisions are made before the time of the actual paddle press. An alternative bit rate measure of performance is defined to show that the system proposed here is able to perform the task with the same efficiency as the rats. PMID:18784389

Dankert, James R; Olson, Byron; Si, Jennie

2008-09-10

489

Asynchronous decision making in a memorized paddle pressing task  

NASA Astrophysics Data System (ADS)

This paper presents a method for asynchronous decision making using recorded neural data in a binary decision task. This is a demonstration of a technique for developing motor cortical neural prosthetics that do not rely on external cued timing information. The system presented in this paper uses support vector machines and leaky integrate-and-fire elements to predict directional paddle presses. In addition to the traditional metrics of accuracy, asynchronous systems must also optimize the time needed to make a decision. The system presented is able to predict paddle presses with a median accuracy of 88% and all decisions are made before the time of the actual paddle press. An alternative bit rate measure of performance is defined to show that the system proposed here is able to perform the task with the same efficiency as the rats.

Dankert, James R.; Olson, Byron; Si, Jennie

2008-12-01

490

Joining of ceramics of different biofunction by hot isostatic pressing  

SciTech Connect

Monolithic zirconia (Z) and zirconia-hydroxyapatite (Z/HA) composites were joined by cold isostatic pressing (CIP at 300 MPa) and subsequently by glass-encapsulated hot isostatic pressing (HIP at 1225 C, 1 h and 200 MPa). The physical and mechanical properties of the materials were measured. The fracture surface was studied using a light microscope. The results indicate a strength level of the joint similar to that of the corresponding composite material (Z/HA), 845 and 860 MPa, respectively. Similar experiments with monolithic alumina (A) and alumina-hydroxyapatite (A/HA) were carried out without success. Cracking occurred in the joint area during the cold isostatic pressing process. It seems that ceramics with high green strength and similar green density are essential when joining ceramics by combined CIP and HIP processes.

Li, Jianguo (Karolinska Inst., Huddinge (Sweden). Center for Dental Technology and Biomaterials); Harmansson, L. (Doxa Certex AB, Uppsala (Sweden)); Soeremark, R. (Karolinska Inst., Huddinge (Sweden). Dept. of Prosthodontics)

1993-10-01

491

Method for hot pressing irregularly shaped refractory articles  

DOEpatents

The present invention is directed to a method for hot pressing irregularly haped refractory articles with these articles of varying thickness being provided with high uniform density and dimensional accuracy. Two partially pressed compacts of the refractory material are placed in a die cavity between displaceable die punches having compact-contacting surfaces of the desired article configuration. A floating, rotatable block is disposed between the compacts. The displacement of the die punches towards one another causes the block to rotate about an axis normal to the direction of movement of the die punches to uniformly distribute the pressure loading upon the compacts for maintaining substantially equal volume displacement of the powder material during the hot pressing operation.

Steinkamp, William E. (Clinton, TN); Ballard, Ambrose H. (Knoxville, TN)

1982-01-01

492

Distinct spatial expression patterns of AP2alpha and AP2gamma in non-neoplastic human breast and breast cancer  

Microsoft Academic Search

Although transcription factors AP-2alpha and AP-2gamma have been implicated in the control of estrogen receptor (ER) and ErbB-2, their impact for breast cancer is still controversial. To better understand the role of AP-2 proteins in mammary neoplasia, the analysis of their spatial expression pattern in normal breast and breast cancer is required. A total of 51 specimens of female breast

Nicolaus Friedrichs; Richard Jger; Ellen Paggen; Christian Rudlowski; Sabine Merkelbach-Bruse; Hubert Schorle; Reinhard Buettner

2005-01-01

493

AP1 transrepressing retinoic acid does not deplete coactivators or AP1 monomers but may target specific Jun or Fos containing dimers  

Microsoft Academic Search

Retinoic acid (RA) inhibits tumor promotion in many models in vivo and in vitro, among them mouse epidermal JB6 cells. RA treatment suppresses 12-O-tetradecanoylphorbol-13-acetate (TPA) induced AP-1 activity, an activity that is required for transformation of JB6 P+ cells. The molecular mechanism of AP-1 transrepression by retinoids is unclear, especially as related to inhibition of transformation. Overexpression of AP-1 components

Kazumi Suzukawa; Nancy H Colburn

2002-01-01

494

Angiopoietin-1 promotes endothelial cell proliferation and migration through AP-1-dependent autocrine production of interleukin-8.  

PubMed

Angiopoietin-1 (Ang-1), ligand for the endothelial cell-specific Tie-2 receptors, promotes migration and proliferation of endothelial cells, however, whether these effects are promoted through the release of a secondary mediator remains unclear. In this study, we assessed whether Ang-1 promotes endothelial cell migration and proliferation through the release of interleukin-8 (IL-8). Ang-1 elicited in human umbilical vein endothelial cells (HUVECs) a dose- and time-dependent increase in IL-8 production as a result of induction of mRNA and enhanced mRNA stability of IL-8 transcripts. IL-8 production is also elevated in HUVECs transduced with retroviruses expressing Ang-1. Neutralization of IL-8 in these cells with a specific antibody significantly attenuated proliferation and migration and induced caspase-3 activation. Exposure to Ang-1 triggered a significant increase in DNA binding of activator protein-1 (AP-1) to a relatively short fragment of IL-8 promoter. Upstream from the AP-1 complex, up-regulation of IL-8 transcription by Ang-1 was mediated through the Erk1/2, SAPK/JNK, and PI-3 kinase pathways, which triggered c-Jun phosphorylation on Ser63 and Ser73. These results suggest that promotion of endothelial migration and proliferation by Ang-1 is mediated, in part, through the production of IL-8, which acts in an autocrine fashion to suppress apoptosis and facilitate cell proliferation and migration. PMID:18252863

Abdel-Malak, Nelly A; Srikant, Coimbatore B; Kristof, Arnold S; Magder, Sheldon A; Di Battista, John A; Hussain, Sabah N A

2008-02-05

495

Loss of lever press-related firing of rat striatal forelimb neurons after repeated sessions in a lever pressing task.  

PubMed

Lateral striatal neurons that fire phasically in relation to active movement of the contralateral forelimb (determined via daily sensorimotor examination) were studied during acquisition of cued lever pressing. Rats were trained to lift the contralateral forepaw from the floor to press a lever in the presence of a tone. The tone was presented 70 times per day (session) for 18 consecutive days. All animals acquired the task, evidenced by gradual improvements across sessions and eventual asymptotic levels in tone discrimination, reaction time, and efficiency of the lever press. Forelimb neurons fired in relation to the lever press during early sessions of acquisition but not after repeated sessions on the task. This difference in firing could not be attributed to differences in forelimb movements during lever pressing or to sampling from different populations of neurons in early versus late sessions. In view of evidence that striatal damage impairs acquisition of motor skills, the change in firing suggests that the striatal activity present in early sessions may be necessary for the acquisition of, but not the automatic performance of, learned motor responses. PMID:9030639

Carelli, R M; Wolske, M; West, M O

1997-03-01

496

Measurements of ground motion and magnet vibrations at the APS  

SciTech Connect

This article presents results of ground motion and magnet vibrations measurements at the Advanced Photon Source. The experiments were done over a wide, frequency range (0-05-100 Hz) with the use of SM-3KV-type seismic probes from the Budker Institute of Nuclear Physics (Russia). Spectral power densities of vertical and horizontal motions of the APS hall floor and quadrupoles on regular supports were obtained. Also investigated were magnet vibrations induced by designed cooling water flow and spectral characteristics of spatial correlation of the quadrupole vibrations at different sectors of the ring. The influence of personnel activity in the hall and traffic under the ring on the slow motion of storage ring elements were observed. Amplitudes of vibrations at the APS are compared with results of seismic measurements at some other accelerators.

Shiltsev, V. [Budker INP, Novosibirsk (Russian Federation)

1996-09-01

497

The APS booster synchrotron: Commissioning and operational experience  

SciTech Connect

The Advanced Photon Source (APS) at Argonne National Laboratory (ANL) was constructed to provide a large user community with intense and high brightness synchrotron radiation at x-ray wavelengths. A 7-GeV positron beam is used to generate this light. Acceleration of the beam from 450 MeV to 7 GeV is accomplished at a 2-Hz repetition rate by the booster synchrotron. Commissioning of the booster began in the second quarter of 1994 and continued on into early 1995. The booster is now routinely used to provide beam for the commissioning of the APS storage ring. Reported here are our commissioning and operational experiences with the booster synchrotron.

Milton, S.V.

1995-07-01

498

Tank 241-AP-107 tank characterization plan. Revision 1  

SciTech Connect

Defense Nuclear Facilities Safety Board has directed the DOE to concentrate ear-term sampling and analysis activities on identification and resolution of issues (Conway 1993). The Data Quality Objective (DQO) process was chosen as a tool to be used in the resolution of safety issues. As a result, a revision in the Federal Facilities Agreement and Consent Order (Tri-Party Agreement) milestone M-44-00 has been made, which states that ``A Tank Characterization Plan (TCP) will be developed for each double-shell tank (DST) and single-shell tank (SST) using the DQO process; Development of TCPs by the DQO process is intended to allow users (e.g., Hanford Facility user groups, regulators) to ensure their needs will be met and that resources are devoted to gaining only necessary information.`` This document satisfies that requirement for the tank 241-AP-107 (AP-107).

Schreiber, R.D. [Westinghouse Hanford Co., Richland, WA (United States)

1995-01-20

499

Status of APS 1-Mwe Parabolic Trough Project  

SciTech Connect

Arizona Public Service (APS) is currently installing new power facilities to generate a portion of its electricity from solar resources that will satisfy its obligation under the Arizona Environmental Portfolio Standard (EPS). During FY04, APS began construction on a 1-MWe parabolic trough concentrating solar power plant. This plant represents the first parabolic trough plant to begin construction since 1991. Site preparation and construction activities continued throughout much of FY05, and startup activities are planned for Fall 2005 (with completion early in FY06). The plant will be the first commercial deployment of the Solargenix parabolic trough collector technology developed under contract to the National Renewable Energy Laboratory. The plant will use an organic Rankine cycle (ORC) power plant, provided by Ormat. The ORC power plant is much simpler than the conventional steam Rankine cycle plant and allows unattended operation of the facility.

Canada, S.; Brosseau, D.; Kolb, G.; Moore, L.; Cable, R.; Price, H.

2005-11-01

500

Process design of press hardening with gradient material property influence  

SciTech Connect

Press hardening is currently used in the production of automotive structures that require very high strength and controlled deformation during crash tests. Press hardening can achieve significant reductions of sheet thickness at constant strength and is therefore a promising technology for the production of lightweight and energy-efficient automobiles. The manganese-boron steel 22MnB5 have been implemented in sheet press hardening owing to their excellent hot formability, high hardenability, and good temperability even at low cooling rates. However, press-hardened components have shown poor ductility and cracking at relatively small strains. A possible solution to this problem is a selective increase of steel sheet ductility by press hardening process design in areas where the component is required to deform plastically during crash tests. To this end, process designers require information about microstructure and mechanical properties as a function of the wide spectrum of cooling rates and sequences and austenitizing treatment conditions that can be encountered in production environments. In the present work, a Continuous Cooling Transformation (CCT) diagram with corresponding material properties of sheet steel 22MnB5 was determined for a wide spectrum of cooling rates. Heating and cooling programs were conducted in a quenching dilatometer. Motivated by the importance of residual elasticity in crash test performance, this property was measured using a micro-bending test and the results were integrated into the CCT diagrams to complement the hardness testing results. This information is essential for the process design of press hardening of sheet components with gradient material properties.

Neugebauer, R. [Fraunhofer Institute for Machine Tools and Forming Technology IWU, Chemnitz (Germany); Professorship for Machine Tools and Forming Technology, TU Chemnitz (Germany); Schieck, F. [Fraunhofer Institute for Machine Tools and Forming Technology IWU, Chemnitz (Germany); Rautenstrauch, A. [Professorship for Machine Tools and Forming Technology, TU Chemnitz (Germany)

2011-05-04