Science.gov

Sample records for aps press release

  1. 7 CFR 550.29 - Press releases.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AGRICULTURE GENERAL ADMINISTRATIVE POLICY FOR NON-ASSISTANCE COOPERATIVE AGREEMENTS Management of Agreements Program Management 550.29 Press releases. Press releases or other forms of public notification will...

  2. 7 CFR 550.29 - Press releases.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AGRICULTURE GENERAL ADMINISTRATIVE POLICY FOR NON-ASSISTANCE COOPERATIVE AGREEMENTS Management of Agreements Program Management 550.29 Press releases. Press releases or other forms of public notification will...

  3. 7 CFR 550.29 - Press releases.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AGRICULTURE GENERAL ADMINISTRATIVE POLICY FOR NON-ASSISTANCE COOPERATIVE AGREEMENTS Management of Agreements Program Management 550.29 Press releases. Press releases or other forms of public notification will...

  4. The CAPRI Project: Coordinates for Astronomical Press Release Images

    NASA Astrophysics Data System (ADS)

    Frattare, Lisa M.; Ferguson, B. A.; Summers, F.; Levay, Z. G.

    2009-01-01

    The beauty and splendor of astronomical press release images has made an enormously positive impact with the media and public alike. As a leading provider of astronomical imagery and a major contributor of Hubble Space Telescope press release images, the outreach division of Space Telescope Science Institute (STScI) recognizes the importance of making press release images compliant with virtual observatory standards for inclusion in databases and repositories. Our goal is to make outreach images accessible by virtual observatory applications by calculating World Coordinate System (WCS) data for these images. We provide updated and improved software that allows observatories to easily and accurately transform coordinates on their astronomical press release images, using reference FITS files. The resultant metadata conforms to the Simple Image Access (SIA) protocol established by the International Virtual Observatory Alliance and has been used by popular end users such as Google Sky and World Wide Telescope. Several hundred images from the STScI Office of Public Outreach NewsCenter database have been processed, and their coordinates and other relevant metadata are accessible through an SIA-compliant web service.

  5. Modulation of Venlafaxine Hydrochloride Release from Press Coated Matrix Tablet

    PubMed Central

    Gohel, M. C.; Soni, C. D.; Nagori, S. A.; Sarvaiya, K. G.

    2008-01-01

    The aim of present study was to prepare novel modified release press coated tablets of venlafaxine hydrochloride. Hydroxypropylmethylcellulose K4M and hydroxypropylmethylcellulose K100M were used as release modifier in core and coat, respectively. A 32 full factorial design was adopted in the optimization study. The drug to polymer ratio in core and coat were chosen as independent variables. The drug release in the first hour and drug release rate between 1 and 12 h were chosen as dependent variables. The tablets were characterized for dimension analysis, crushing strength, friability and in vitro drug release. A check point batch, containing 1:2.6 and 1:5.4 drug to polymer in core and coat respectively, was prepared. The tablets of check point batch were subjected to in vitro drug release in dissolution media with pH 5, 7.2 and distilled water. The kinetics of drug release was best explained by Korsmeyer and Peppas model (anomalous non-Fickian diffusion). The systematic formulation approach enabled us to develop modified release venlafaxine hydrochloride tablets. PMID:20046735

  6. OPEC official resolutions and press releases 1960-1983

    SciTech Connect

    Not Available

    1984-01-01

    This book presents resolutions adopted by the OPEC Conference constitute a unique and historic documentary record of the Organization's achievements in the 23 years since its foundation in Baghdad in 1960. Also included in this special work of reference is a selection of Press Releases which announced important developments in OPEC's evolution. Arranged in chronological order, these documents provide a step-by-step account of the major developments which have had such a profound effect and continuing impact on the world's economic affairs.

  7. Influence of medical journal press releases on the quality of associated newspaper coverage: retrospective cohort study

    PubMed Central

    Schwartz, Lisa M; Andrews, Alice; Stukel, Therese A

    2012-01-01

    Objective To determine whether the quality of press releases issued by medical journals can influence the quality of associated newspaper stories. Design Retrospective cohort study of medical journal press releases and associated news stories. Setting We reviewed consecutive issues (going backwards from January 2009) of five major medical journals (Annals of Internal Medicine, BMJ, Journal of the National Cancer Institute, JAMA, and New England Journal of Medicine) to identify the first 100 original research articles with quantifiable outcomes and that had generated any newspaper coverage (unique stories ≥100 words long). We identified 759 associated newspaper stories using Lexis Nexis and Factiva searches, and 68 journal press releases using Eurekalert and journal website searches. Two independent research assistants assessed the quality of journal articles, press releases, and a stratified random sample of associated newspaper stories (n=343) by using a structured coding scheme for the presence of specific quality measures: basic study facts, quantification of the main result, harms, and limitations. Main outcome Proportion of newspaper stories with specific quality measures (adjusted for whether the quality measure was present in the journal article’s abstract or editor note). Results We recorded a median of three newspaper stories per journal article (range 1-72). Of 343 stories analysed, 71% reported on articles for which medical journals had issued press releases. 9% of stories quantified the main result with absolute risks when this information was not in the press release, 53% did so when it was in the press release (relative risk 6.0, 95% confidence interval 2.3 to 15.4), and 20% when no press release was issued (2.2, 0.83 to 6.1). 133 (39%) stories reported on research describing beneficial interventions. 24% mentioned harms (or specifically declared no harms) when harms were not mentioned in the press release, 68% when mentioned in the press release (2.8, 1.1 to 7.4), and 36% when no press release was issued (1.5, 0.49 to 4.4). 256 (75%) stories reported on research with important limitations. 16% reported any limitations when limitations were not mentioned in the press release, 48% when mentioned in the press release (3.0, 1.5 to 6.2), and 21% if no press release was issued (1.3, 0.50 to 3.6). Conclusion High quality press releases issued by medical journals seem to make the quality of associated newspaper stories better, whereas low quality press releases might make them worse. PMID:22286507

  8. Misrepresentation of Randomized Controlled Trials in Press Releases and News Coverage: A Cohort Study

    PubMed Central

    Yavchitz, Amélie; Boutron, Isabelle; Bafeta, Aida; Marroun, Ibrahim; Charles, Pierre; Mantz, Jean; Ravaud, Philippe

    2012-01-01

    Background Previous studies indicate that in published reports, trial results can be distorted by the use of “spin” (specific reporting strategies, intentional or unintentional, emphasizing the beneficial effect of the experimental treatment). We aimed to (1) evaluate the presence of “spin” in press releases and associated media coverage; and (2) evaluate whether findings of randomized controlled trials (RCTs) based on press releases and media coverage are misinterpreted. Methods and Findings We systematically searched for all press releases indexed in the EurekAlert! database between December 2009 and March 2010. Of the 498 press releases retrieved and screened, we included press releases for all two-arm, parallel-group RCTs (n = 70). We obtained a copy of the scientific article to which the press release related and we systematically searched for related news items using Lexis Nexis. “Spin,” defined as specific reporting strategies (intentional or unintentional) emphasizing the beneficial effect of the experimental treatment, was identified in 28 (40%) scientific article abstract conclusions and in 33 (47%) press releases. From bivariate and multivariable analysis assessing the journal type, funding source, sample size, type of treatment (drug or other), results of the primary outcomes (all nonstatistically significant versus other), author of the press release, and the presence of “spin” in the abstract conclusion, the only factor associated, with “spin” in the press release was “spin” in the article abstract conclusions (relative risk [RR] 5.6, [95% CI 2.8–11.1], p<0.001). Findings of RCTs based on press releases were overestimated for 19 (27%) reports. News items were identified for 41 RCTs; 21 (51%) were reported with “spin,” mainly the same type of “spin” as those identified in the press release and article abstract conclusion. Findings of RCTs based on the news item was overestimated for ten (24%) reports. Conclusion “Spin” was identified in about half of press releases and media coverage. In multivariable analysis, the main factor associated with “spin” in press releases was the presence of “spin” in the article abstract conclusion. PMID:22984354

  9. The association between exaggeration in health related science news and academic press releases: retrospective observational study

    PubMed Central

    Vivian-Griffiths, Solveiga; Boivin, Jacky; Williams, Andy; Venetis, Christos A; Davies, Aimée; Ogden, Jack; Whelan, Leanne; Hughes, Bethan; Dalton, Bethan; Boy, Fred

    2014-01-01

    Objective To identify the source (press releases or news) of distortions, exaggerations, or changes to the main conclusions drawn from research that could potentially influence a reader’s health related behaviour. Design Retrospective quantitative content analysis. Setting Journal articles, press releases, and related news, with accompanying simulations. Sample Press releases (n=462) on biomedical and health related science issued by 20 leading UK universities in 2011, alongside their associated peer reviewed research papers and news stories (n=668). Main outcome measures Advice to readers to change behaviour, causal statements drawn from correlational research, and inference to humans from animal research that went beyond those in the associated peer reviewed papers. Results 40% (95% confidence interval 33% to 46%) of the press releases contained exaggerated advice, 33% (26% to 40%) contained exaggerated causal claims, and 36% (28% to 46%) contained exaggerated inference to humans from animal research. When press releases contained such exaggeration, 58% (95% confidence interval 48% to 68%), 81% (70% to 93%), and 86% (77% to 95%) of news stories, respectively, contained similar exaggeration, compared with exaggeration rates of 17% (10% to 24%), 18% (9% to 27%), and 10% (0% to 19%) in news when the press releases were not exaggerated. Odds ratios for each category of analysis were 6.5 (95% confidence interval 3.5 to 12), 20 (7.6 to 51), and 56 (15 to 211). At the same time, there was little evidence that exaggeration in press releases increased the uptake of news. Conclusions Exaggeration in news is strongly associated with exaggeration in press releases. Improving the accuracy of academic press releases could represent a key opportunity for reducing misleading health related news. PMID:25498121

  10. Widespread Dysregulation of Peptide Hormone Release in Mice Lacking Adaptor Protein AP-3

    PubMed Central

    Sirkis, Daniel W.; Edwards, Robert H.; Asensio, Cdric S.

    2013-01-01

    The regulated secretion of peptide hormones, neural peptides and many growth factors depends on their sorting into large dense core vesicles (LDCVs) capable of regulated exocytosis. LDCVs form at the trans-Golgi network, but the mechanisms that sort proteins to this regulated secretory pathway and the cytosolic machinery that produces LDCVs remain poorly understood. Recently, we used an RNAi screen to identify a role for heterotetrameric adaptor protein AP-3 in regulated secretion and in particular, LDCV formation. Indeed, mocha mice lacking AP-3 have a severe neurological and behavioral phenotype, but this has been attributed to a role for AP-3 in the endolysosomal rather than biosynthetic pathway. We therefore used mocha mice to determine whether loss of AP-3 also dysregulates peptide release in vivo. We find that adrenal chromaffin cells from mocha animals show increased constitutive exocytosis of both soluble cargo and LDCV membrane proteins, reducing the response to stimulation. We also observe increased basal release of both insulin and glucagon from pancreatic islet cells of mocha mice, suggesting a global disturbance in the release of peptide hormones. AP-3 exists as both ubiquitous and neuronal isoforms, but the analysis of mice lacking each of these isoforms individually and together shows that loss of both is required to reproduce the effect of the mocha mutation on the regulated pathway. In addition, we show that loss of the related adaptor protein AP-1 has a similar effect on regulated secretion but exacerbates the effect of AP-3 RNAi, suggesting distinct roles for the two adaptors in the regulated secretory pathway. PMID:24086151

  11. Corporate Responsibility in Communication: Empirical Analysis of Press Releases in a Conflict

    ERIC Educational Resources Information Center

    Lehtimaki, Hanna; Kujala, Johanna; Heikkinen, Anna

    2011-01-01

    The paper examines how the tensions of corporate responsibility are articulated and reconciled in a controversial situation of a foreign investment. We conducted a conventionalist analysis on the company press releases in a case where a Finnish forest industry company invested in a pulp mill in South America. The findings show that the use of…

  12. Distorting Genetic Research about Cancer: From Bench Science to Press Release to Published News1

    PubMed Central

    Brechman, Jean M.; Lee, Chul-joo; Cappella, Joseph

    2014-01-01

    This study considered genetic research relating to cancer outcomes and behaviors, specifically investigating the extent to which claims made in press releases (N=23) and mainstream print media (N=71) were fairly derived from their original presentation in scholarly journals (N=20). Central claims expressing gene-outcome relationships were evaluated by a large pool (N=40) of genetics graduate students. Raters judged press release claims as significantly more representative of material within the original science journal article compared with news article claims. Claims originating in news articles which demonstrated contact with individuals not directly involved in the research were judged by experts to be more representative of the original science as compared with those that demonstrated contact with individuals directly involved in the research. PMID:25580022

  13. The Rural Restaurant Healthy Options Program: Response of Rural, Local Newspapers to a Program Press Release

    PubMed Central

    Nothwehr, Faryle; Andsager, Julie; Haines, Heidi

    2014-01-01

    Local media should be used to raise awareness of health promotion programs. In rural areas, local newspapers provide an opportunity to reach large numbers of residents. Although there are expert guidelines describing the process for successfully engaging local media, little has been documented regarding the range of responses that local, rural newspapers might have when approached about covering health promotion programs. This study describes the response of rural, local newspapers to a press release about a health promotion program taking place in 28 restaurants in different rural towns. The most common reason for not publishing a story was that it would constitute free advertising for the restaurant. Twenty-two stories were analyzed using descriptive statistics. The majority of the responding newspapers were weeklies, and 16 published the full press release verbatim. Three stories included photos, and five included quotes. Headlines typically included the name of the restaurant and the university partner. The overall response rate is encouraging; however, there is considerable room for improvement in terms of personalizing the story with photos or quotes. Greater efforts may be required to obtain this depth of coverage, including training for local journalists to increase their interest and confidence in covering health promotion issues. PMID:23182860

  14. Outrage Factors in Government Press Releases of Food Risk and Their Influence on News Media Coverage.

    PubMed

    Ju, Youngkee; Lim, Jeongsub; Shim, Minsun; You, Myoungsoon

    2015-08-01

    An appropriate level of risk perception should be a critical issue in modern "risk society." There have been many studies on the influences on risk perception. This study investigates whether risk communication scholar Dr. Peter Sandman's outrage factors intensify journalistic attention to health risks from food consumption. A content analysis of a health institution's press releases was conducted to examine 15 outrage factors of food risks conveyed in the governmental risk communication. In addition, the news stories covering the food risks informed by the press releases were calculated to evaluate the relation between outrage factors of a risk and the number of news stories covering the risk. Results showed that controllability was the most salient outrage factor, followed by trust, voluntariness, familiarity, and human origin; the greater the outrage score of a risk, the more news stories of the risk. For individual outrage factors, a risk with an implication of catastrophic potential was associated with an increase of news stories. Food providers' distrustful behaviors also influenced journalistic attention to the food risks. The implication of the findings to health message designers is discussed. PMID:26065830

  15. The rural restaurant healthy options program: response of rural, local newspapers to a program press release.

    PubMed

    Nothwehr, Faryle; Andsager, Julie; Haines, Heidi

    2014-03-01

    Local media should be used to raise awareness of health promotion programs. In rural areas, local newspapers provide an opportunity to reach large numbers of residents. Although there are expert guidelines describing the process for successfully engaging local media, little has been documented regarding the range of responses that local, rural newspapers might have when approached about covering health promotion programs. This study describes the response of rural, local newspapers to a press release about a health promotion program taking place in 28 restaurants in different rural towns. The most common reason for not publishing a story was that it would constitute free advertising for the restaurant. Twenty-two stories were analyzed using descriptive statistics. The majority of the responding newspapers were weeklies, and 16 published the full press release verbatim. Three stories included photos, and five included quotes. Headlines typically included the name of the restaurant and the university partner. The overall response rate is encouraging; however, there is considerable room for improvement in terms of personalizing the story with photos or quotes. Greater efforts may be required to obtain this depth of coverage, including training for local journalists to increase their interest and confidence in covering health promotion issues. PMID:23182860

  16. From press release to news: mapping the framing of the 2009 H1N1 A influenza pandemic.

    PubMed

    Lee, Seow Ting; Basnyat, Iccha

    2013-01-01

    Pandemics challenge conventional assumptions about health promotion, message development, community engagement, and the role of news media. To understand the use of press releases in news coverage of pandemics, this study traces the development of framing devices from a government public health agency's press releases to news stories about the 2009 H1N1 A influenza pandemic. The communication management of the H1N1 pandemic, an international news event with local implications, by the Singapore government is a rich locus for understanding the dynamics of public relations, health communication, and journalism. A content analysis shows that the evolution of information from press release to news is marked by significant changes in media frames, including the expansion and diversification in dominant frames and emotion appeals, stronger thematic framing, more sources of information, conversion of loss frames into gain frames, and amplification of positive tone favoring the public health agency's position. Contrary to previous research that suggests that government information subsidies passed almost unchanged through media gatekeepers, the news coverage of the pandemic reflects journalists' selectivity in disseminating the government press releases and in mediating the information flow and frames from the press releases. PMID:22439616

  17. Lost in Translation? A Comparison of Cancer-Genetics Reporting in the Press Release and its Subsequent Coverage in Lay Press1

    PubMed Central

    Brechman, Jean M.; Lee, Chul-joo; Cappella, Joseph N.

    2014-01-01

    Understanding how genetic science is communicated to the lay public is of great import, given that media coverage of genetics is increasing exponentially and that the ways in which discoveries are presented in the news can have significant effects on a variety of health outcomes. To address this issue, this study examines the presentation of genetic research relating to cancer outcomes and behaviors (i.e., prostate cancer, breast cancer, colon cancer, smoking and obesity) in both the press release (N = 23) and its subsequent news coverage (N = 71) by using both quantitative content analysis and qualitative textual analysis. In contrast to earlier studies reporting that news stories often misrepresent genetics by presenting biologically deterministic and simplified portrayals (e.g., Mountcastle-Shah et al., 2003; Ten Eych & Williment, 2003), our data shows no clear trends in the direction of distortion toward deterministic claims in news articles. Also, other errors commonly attributed to science journalism, such as lack of qualifying details and use of oversimplified language (e.g., “fat gene”) are observed in press releases. These findings suggest that the intermediary press release rather than news coverage may serve as a source of distortion in the dissemination of science to the lay public. The implications of this study for future research in this area are discussed. PMID:25568611

  18. Coverage of Team Science by Public Information Officers: Content Analysis of Press Releases about the National Science Foundation Science and Technology Centers

    ERIC Educational Resources Information Center

    Graube, Marita; Clark, Fiona; Illman, Deborah L.

    2010-01-01

    This study examines the content of press releases from the National Science Foundation (NSF) Science and Technology Centers (STCs) to determine how public information officers (PIOs) presented the outcomes of centers to journalists and the public. A total of 68 press releases were analyzed for type of news covered, visibility of centers and their…

  19. Disruption of adaptor protein 2μ (AP-2μ) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing.

    PubMed

    Jung, SangYong; Maritzen, Tanja; Wichmann, Carolin; Jing, Zhizi; Neef, Andreas; Revelo, Natalia H; Al-Moyed, Hanan; Meese, Sandra; Wojcik, Sonja M; Panou, Iliana; Bulut, Haydar; Schu, Peter; Ficner, Ralf; Reisinger, Ellen; Rizzoli, Silvio O; Neef, Jakob; Strenzke, Nicola; Haucke, Volker; Moser, Tobias

    2015-11-01

    Active zones (AZs) of inner hair cells (IHCs) indefatigably release hundreds of vesicles per second, requiring each release site to reload vesicles at tens per second. Here, we report that the endocytic adaptor protein 2μ (AP-2μ) is required for release site replenishment and hearing. We show that hair cell-specific disruption of AP-2μ slows IHC exocytosis immediately after fusion of the readily releasable pool of vesicles, despite normal abundance of membrane-proximal vesicles and intact endocytic membrane retrieval. Sound-driven postsynaptic spiking was reduced in a use-dependent manner, and the altered interspike interval statistics suggested a slowed reloading of release sites. Sustained strong stimulation led to accumulation of endosome-like vacuoles, fewer clathrin-coated endocytic intermediates, and vesicle depletion of the membrane-distal synaptic ribbon in AP-2μ-deficient IHCs, indicating a further role of AP-2μ in clathrin-dependent vesicle reformation on a timescale of many seconds. Finally, we show that AP-2 sorts its IHC-cargo otoferlin. We propose that binding of AP-2 to otoferlin facilitates replenishment of release sites, for example, via speeding AZ clearance of exocytosed material, in addition to a role of AP-2 in synaptic vesicle reformation. PMID:26446278

  20. EVALUATION OF CHEMICAL RELEASES AND WORKER EXPOSURES FROM FILTER PRESS OPERATIONS

    EPA Science Inventory

    The exposures (inhalation and dermal) and releases (air, water, solids, and process streams) associated with the filtration of industrial wastewater sludge from an electronics manufacturing plant were characterized. Chemical releases and worker exposures for a target chemical (t...

  1. EVALUATION OF CHEMICAL RELEASES AND WORKER EXPOSURES FROM FILTER PRESS OPERATIONS

    EPA Science Inventory

    The exposures (inhalation and dermal) and releases (air, water, solids, and process streams) associated with the filtration of industrial wastewater sludge from an electronics manufacturing plant were characterized. hemical releases and worker exposures for a target chemical (tot...

  2. Press Releases Issued by Supplements Industry Organisations and Non-Industry Organisations in Response to Publication of Clinical Research Findings: A Case-Control Study

    PubMed Central

    Wang, Michael T. M.; Gamble, Greg; Bolland, Mark J.; Grey, Andrew

    2014-01-01

    Background Dietary supplement use is increasing despite lack of evidence of benefits, or evidence of harm. Press releases issued by the supplements industry might contribute to this situation by using ‘spin’ (strategies to hype or denigrate findings) to distort the results of clinical studies. We assessed press releases issued in response to publication of clinical studies on dietary supplements. Methods and Findings We analyzed 47 supplements industry press releases and 91 non-industry press releases and news stories, generated in response to 46 clinical studies of dietary supplements published between 1/1/2005 and 5/31/2013. The primary outcome was ‘spin’ content and direction. We also assessed disposition towards use of dietary supplements, reporting of study information, and dissemination of industry press releases. More supplements industry press releases (100%) contained ‘spin’ than non-industry media documents (55%, P<0.001). Hyping ‘spin’ scores were higher in industry than non-industry media documents for studies reporting benefit of supplements (median ‘spin’ score 3.3, 95% CI 1.0–5.5 vs 0.5, 0–1.0; P<0.001). Denigratory ‘spin’ scores were higher in industry than non-industry media documents for studies reporting no effect (6.0, 5.0–7.0 vs 0, 0–0; P<0.001) or harm (6.0, 5.5–7.5 vs 0, 0–0.5; P<0.001) from a supplement. Industry press releases advocated supplement use in response to >90% of studies that reported no benefit, or harm, of the supplement. Industry press releases less frequently reported study outcomes, sample size, and estimates of effect size than non-industry media documents (all P<0.001), particularly for studies that reported no benefit of supplements. Industry press releases were referenced by 148 news stories on the websites of 6 organizations that inform manufacturers, retailers and consumers of supplements. Conclusions Dietary supplements industry press releases issued in response to clinical research findings are characterized by ‘spin’ that hypes results that are favourable to supplement use and denigrates results that are not. PMID:24992571

  3. When Medical News Comes from Press Releases-A Case Study of Pancreatic Cancer and Processed Meat.

    PubMed

    Taylor, Joseph W; Long, Marie; Ashley, Elizabeth; Denning, Alex; Gout, Beatrice; Hansen, Kayleigh; Huws, Thomas; Jennings, Leifa; Quinn, Sinead; Sarkies, Patrick; Wojtowicz, Alex; Newton, Philip M

    2015-01-01

    The media have a key role in communicating advances in medicine to the general public, yet the accuracy of medical journalism is an under-researched area. This project adapted an established monitoring instrument to analyse all identified news reports (n = 312) on a single medical research paper: a meta-analysis published in the British Journal of Cancer which showed a modest link between processed meat consumption and pancreatic cancer. Our most significant finding was that three sources (the journal press release, a story on the BBC News website and a story appearing on the 'NHS Choices' website) appeared to account for the content of over 85% of the news stories which covered the meta analysis, with many of them being verbatim or moderately edited copies and most not citing their source. The quality of these 3 primary sources varied from excellent (NHS Choices, 10 of 11 criteria addressed) to weak (journal press release, 5 of 11 criteria addressed), and this variance was reflected in the accuracy of stories derived from them. Some of the methods used in the original meta-analysis, and a proposed mechanistic explanation for the findings, were challenged in a subsequent commentary also published in the British Journal of Cancer, but this discourse was poorly reflected in the media coverage of the story. PMID:26083640

  4. Thermally induced atomic diffusion at the interface between release agent coating and mould substrate in a glass moulding press

    NASA Astrophysics Data System (ADS)

    Masuda, Jun; Yan, Jiwang; Zhou, Tianfeng; Kuriyagawa, Tsunemoto; Fukase, Yasushi

    2011-06-01

    In a glass moulding press (GMP) for refractive/diffractive hybrid lenses, to improve the service life of nickel-phosphorus (Ni-P) plated moulds, it is necessary to control the diffusion of constituent elements from the mould into the release agent coating. In this study, diffusion phenomena of constituents of Ni-P plating are investigated for two types of release agent coatings, iridium-platinum (Ir-Pt) and iridium-rhenium (Ir-Re), by cross-sectional observation, compositional analysis and stress measurements. The results show that Ni atoms in the plating layer flow from regions of compressive stress to regions of tensile stress. In the case of the Ir-Pt coated mould, the diffusion of Ni is promoted from the grain boundaries between the Ni and Ni3P phases in the plating towards the surface of the Ir-Pt coating. However, in the Ir-Re coated mould, the diffusion of Ni is suppressed because the diffusion coefficient of Ni in the Ir-Re alloy is smaller than that in the Ir-Pt alloy, although the stress state is similar in both cases. By controlling the diffusion of Ni atoms, the use of Ir-Re alloy as a release agent coating for Ni-P plated moulds is expected to lead to a high degree of durability.

  5. Properties of tritium/helium release from hot isostatic pressed beryllium of various trademarks

    NASA Astrophysics Data System (ADS)

    Chekushina, Lyudmila; Dyussambaev, Daulet; Shaimerdenov, Asset; Tsuchiya, Kunihiko; Takeuchi, Tomoaki; Kawamura, Hiroshi; Kulsartov, Timur

    2014-09-01

    Samples of three industrial beryllium trademarks, such as S-200F, S-65H and I-220H are irradiated at about 40 °C to the fluence of 1.5 × 1024 m-2 (E > 1.15 MeV) in reactor WWR-K. On completion of irradiation tests, post irradiation examinations (PIEs) against hardness are carried out, X-ray diffraction (XRD) analysis and scanning electron microscope (SEM) observation. Also He/T2 release properties are measured by the thermal desorption (TDS) method. Relevant obtained values of amounts of the released tritium and helium for all samples of irradiated beryllium are in good agreement, within inaccuracy, comprising 25 ± 3 wppm for helium-4 and 1.3 ± 0.3 wppm for tritium.

  6. Reciprocating pellet press

    DOEpatents

    Jones, Charles W.

    1981-04-07

    A machine for pressing loose powder into pellets using a series of reciprocating motions has an interchangeable punch and die as its only accurately machines parts. The machine reciprocates horizontally between powder receiving and pressing positions. It reciprocates vertically to press, strip and release a pellet.

  7. Landslide incidence in the North of Portugal: Analysis of a historical landslide database based on press releases and technical reports

    NASA Astrophysics Data System (ADS)

    Pereira, Susana; Zêzere, José Luís; Quaresma, Ivânia Daniela; Bateira, Carlos

    2014-06-01

    This work presents and explores the Northern Portugal Landslide Database (NPLD) for the period 1900-2010. NPLD was compiled from press releases (regional and local newspapers) and technical reports (reports by civil protection authorities and academic works); it includes 628 landslides, corresponding to 5.7 landslides per year on average. Although 50% of landslides occurred in the last 35 years of the series, the temporal distribution of landslides does not show any regular increase with time. The relationship between annual precipitation and landslide occurrence shows that reported landslides tend to be more frequent in wetter years. Moreover, landslides occur mostly in the wettest months of the year (December, January and February), which reflects the importance of rainfall in triggering slope instability. Most landslides cause damage that affects people and/or structures; 69.4% of the landslides in Northern Portugal caused 136 fatalities, 173 injured and left 460 persons homeless. More than half of the total landslides (321 landslides) led to railway or motorway closures and 49 landslides destroyed 126 buildings. The NPLD is compared with a landslide database for the whole of Portugal constructed from a single daily national newspaper covering the same reference period. It will be demonstrated that the regional and local newspapers are more effective than the national newspaper in reporting damaging landslides in the North of Portugal. Like other documentary-based landslide inventories, the NPLD does not accurately report non-damaging landslides. Therefore, NPLD was found unsuitable to validate municipal-scale landslide susceptibility models derived from detailed geomorphology-based landslide inventories.

  8. A Guide to Press Relations.

    ERIC Educational Resources Information Center

    Fibre Box Association, Chicago, IL.

    Stressing that a positive press-relations program can be extremely helpful to businesses, this publication offers suggestions for establishing press contacts, preparing press releases, holding press conferences, illustrating a story, preparing materials for use in radio and television broadcasts, and developing policies to be followed in emergency…

  9. 76 FR 6328 - Official Release of the January 2011 AP-42 Method for Estimating Re-Entrained Road Dust From...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-04

    ... emissions model for SIPs and regional conformity purposes (75 FR 9411) and of the MOVES2010a and EMFAC models for transportation conformity hot-spot analyses (75 FR 79370). The January 2011 AP-42 method... grace period in the preamble to the 1993 transportation conformity rule (58 FR 62211): EPA and DOT...

  10. Drill Presses.

    ERIC Educational Resources Information Center

    Engelbrecht, Nancy; And Others

    These instructional materials provide an orientation to the drill press for use at the postsecondary level. The first of seven sections lists seven types of drill presses. The second section identifies 14 drill press parts. The third section lists 21 rules for safe use of drilling machines. The fourth section identifies the six procedures for…

  11. Media Coverage, Journal Press Releases and Editorials Associated with Randomized and Observational Studies in High-Impact Medical Journals: A Cohort Study

    PubMed Central

    Wang, Michael T. M.; Bolland, Mark J.; Gamble, Greg; Grey, Andrew

    2015-01-01

    Background Publication of clinical research findings in prominent journals influences health beliefs and medical practice, in part by engendering news coverage. Randomized controlled trials (RCTs) should be most influential in guiding clinical practice. We determined whether study design of clinical research published in high-impact journals influences media coverage. Methods and Findings We compared the incidence and amount of media coverage of RCTs with that of observational studies published in the top 7 medical journals between 1 January 2013 and 31 March 2013. We specifically assessed media coverage of the most rigorous RCTs, those with >1000 participants that reported ‘hard’ outcomes. There was no difference between RCTs and observational studies in coverage by major newspapers or news agencies, or in total number of news stories generated (all P>0.63). Large RCTs reporting ‘hard’ outcomes did not generate more news coverage than small RCTs that reported surrogate outcomes and observational studies (all P>0.32). RCTs were more likely than observational studies to attract a journal editorial (70% vs 46%, P = 0.003), but less likely to be the subject of a journal press release (17% vs 50%, P<0.001). Large RCTs that reported ‘hard’ outcomes did not attract an editorial more frequently than other studies (61% vs 58%, P>0.99), nor were they more likely to be the subject of a journal press release (14% vs 38%, P = 0.14). Conclusions The design of clinical studies whose results are published in high-impact medical journals is not associated with the likelihood or amount of ensuing news coverage. PMID:26701758

  12. Pycnogenol Attenuates the Release of Proinflammatory Cytokines and Expression of Perilipin 2 in Lipopolysaccharide-Stimulated Microglia in Part via Inhibition of NF-κB and AP-1 Activation

    PubMed Central

    Fan, Bin; Dun, Sai-Hong; Gu, Jian-Qiu; Guo, Yang; Ikuyama, Shoichiro

    2015-01-01

    Over activation of microglia results in the production of proinflammatory agents that have been implicated in various brain diseases. Pycnogenol is a patented extract from French maritime pine bark (Pinus pinaster Aiton) with strong antioxidant and anti-inflammatory potency. The present study investigated whether pycnogenol may be associated with the production of proinflammatory mediators in lipopolysaccharide-stimulated BV2 (mouse-derived) microglia. It was found that pycnogenol treatment was dose-dependently associated with significantly less release of nitricoxide (NO), TNF-α, IL-6 and IL-1β, and lower levels of intercellular adhesion molecule1 (ICAM-1) and perilipin 2 (PLIN2). Furthermore, this effect was replicated in primary brain microglia. Levels of inducible NO synthase mRNA and protein were attenuated, whereas there was no change in the production of the anti-inflammatory cytokine IL-10. Further evidence indicated that pycnogenol treatment led to the suppression of NF-κB activation through inhibition of p65 translocation into the nucleus and inhibited DNA binding of AP-1, suggesting that these proinflammatory factors are associated with NF-κB and AP-1. We conclude that pycnogenol exerts anti-inflammatory effects through inhibition of the NF-κB and AP-1pathway, and may be useful as a therapeutic agent in the prevention of diseases caused by over activation of microglia. PMID:26367267

  13. AP1000 Design for Security

    SciTech Connect

    Long, L.B.; Cummins, W.E.; Winters, J.W.

    2006-07-01

    Nuclear power plants are protected from potential security threats through a combination of robust structures around the primary system and other vital equipment, security systems and equipment, and defensive strategy. The overall objective for nuclear power plant security is to protect public health and safety by ensuring that attacks or sabotage do not challenge the ability to safely shutdown the plant or protect from radiological releases. In addition, plants have systems, features and operational strategies to cope with external conditions, such as loss of offsite power, which could be created as part of an attack. Westinghouse considered potential security threats during design of the AP1000 PWR. The differences in plant configuration, safety system design, and safe shutdown equipment between existing plants and AP1000 affect potential vulnerabilities. This paper provides an evaluation of AP1000 with respect to vulnerabilities to security threats. The AP1000 design differs from the design of operating PWRs in the US in the configuration and the functional requirements for safety systems. These differences are intentional departures from conventional PWR designs which simplify plant design and enhance overall safety. The differences between the AP1000 PWR and conventional PWRs can impact vulnerabilities to security threats. The NRC addressed security concerns as part of their reviews for AP1000 Design Certification, and did not identify any security issues of concern. However, much of the detailed security design information for the AP1000 was deferred to the combined Construction and Operating License (COL) phase as many of the security issues are site-specific. Therefore, NRC review of security issues related to the AP1000 is not necessarily complete. Further, since the AP1000 plant design differs from existing PWRs, it is not obvious that the analyses and assessments prepared for existing plants also apply to the AP1000. We conclude that, overall, the AP1000 is less vulnerable to security threats such as malevolent use of vehicles (land, water or air), than are conventional PWRs. Further, the AP1000 is less vulnerable to external events (e.g., loss of transmission) than conventional PWRs. For some of the threats evaluated the AP1000 is comparable to conventional PWRs, while for other threats the AP1000 is inherently less vulnerable. (authors)

  14. Press Start

    NASA Astrophysics Data System (ADS)

    Harteveld, Casper

    This level sets the stage for the design philosophy called “Triadic Game Design” (TGD). This design philosophy can be summarized with the following sentence: it takes two to tango, but it takes three to design a meaningful game or a game with a purpose. Before the philosophy is further explained, this level will first delve into what is meant by a meaningful game or a game with a purpose. Many terms and definitions have seen the light and in this book I will specifically orient at digital games that aim to have an effect beyond the context of the game itself. Subsequently, a historical overview is given of the usage of games with a serious purpose which starts from the moment we human beings started to walk on our feet till our contemporary society. It turns out that we have been using games for all kinds of non-entertainment purposes for already quite a long time. With this introductory material in the back of our minds, I will explain the concept of TGD by means of a puzzle. After that, the protagonist of this book, the game Levee Patroller, is introduced. Based on the development of this game, the idea of TGD, which stresses to balance three different worlds, the worlds of Reality, Meaning, and Play, came into being. Interested? Then I suggest to quickly “press start!”

  15. The Associated Press Stylebook and Libel Manual. Fully Updated and Revised.

    ERIC Educational Resources Information Center

    Goldstein, Norm, Ed.

    Pointing out that the style of the Associated Press (AP) defines clear writing, this revised edition of the practical and much-used AP stylebook is designed to be an essential handbook for all writers, editors, and students. The stylebook contains over 5000 entries laying out the AP's rules on grammar, spelling, punctuation, and usage. It gives…

  16. 17 CFR 230.135e - Offshore press conferences, meetings with issuer representatives conducted offshore, and press...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Offshore press conferences, meetings with issuer representatives conducted offshore, and press-related materials released offshore. 230... RULES AND REGULATIONS, SECURITIES ACT OF 1933 General § 230.135e Offshore press conferences,...

  17. 17 CFR 230.135e - Offshore press conferences, meetings with issuer representatives conducted offshore, and press...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false Offshore press conferences, meetings with issuer representatives conducted offshore, and press-related materials released offshore. 230... RULES AND REGULATIONS, SECURITIES ACT OF 1933 General § 230.135e Offshore press conferences,...

  18. The Global University Press

    ERIC Educational Resources Information Center

    Dougherty, Peter J.

    2012-01-01

    The modern world's understanding of American university press has long been shaped by university-press books. American university-press books are good international advertisements for the universities whose logos grace their spines. The growth of transnational scholarship and the expansion of digital communications networks are converging in ways…

  19. The Global University Press

    ERIC Educational Resources Information Center

    Dougherty, Peter J.

    2012-01-01

    The modern world's understanding of American university press has long been shaped by university-press books. American university-press books are good international advertisements for the universities whose logos grace their spines. The growth of transnational scholarship and the expansion of digital communications networks are converging in ways

  20. Report Nation March 2015 Press Release

    Cancer.gov

    For the first time, researchers have used national data to determine the incidence of the four major molecular subtypes of breast cancer by age, race/ethnicity, poverty level, and several other factors. The report showed continuing declines in cancer dea

  1. AP-Gate

    ERIC Educational Resources Information Center

    Whitman, Glenn

    2003-01-01

    In May 2001, students in the author's Advanced Placement (AP) United States History class were embroiled in a controversy surrounding the AP exam, in particular, having access to the exam's Document Based Question (DBQ) and free response portion prior to the test's administration. Prior to the exam, the College Board had provided a fifty-year time…

  2. High School Press Pressures.

    ERIC Educational Resources Information Center

    Rogers, Luella P.

    History shows that the high school press suffers through cycles that reflect economic factors and cultural climates within communities, states, and the nation. The direction of that cycle in the 1960s and early 1970s was toward more open, free-flowing information by a vigorous student press, but those economic and cultural signs now are pointing…

  3. PC and the Press.

    ERIC Educational Resources Information Center

    Collins, Huntly

    1992-01-01

    This article examines the issue of "political correctness" on U.S. campuses and suggests that much of the controversy is a creation of the press, has little factual basis, and may be partially a reaction by the press establishment to increased numbers of women and minorities in journalism. (DB)

  4. Lyndon Johnson's Press Conferences.

    ERIC Educational Resources Information Center

    Cooper, Stephen

    Because President Lyndon Johnson understood well the publicity value of the American news media, he sought to exploit them. He saw reporters as "torch bearers" for his programs and policies and used the presidential press conference chiefly for promotional purposes. Although he met with reporters often, his press conferences were usually…

  5. Presidential Press Conferences.

    ERIC Educational Resources Information Center

    Moore, Susan E.

    This report discusses the background, advantages, and disadvantages of the televised presidential press conference, citing the opinions of numerous newspaper and magazine writers. After presenting a brief overview of the presidential press conference from the administration of Theodore Roosevelt to that of Eisenhower, the report discusses the type…

  6. Early Telegraphic News Dispatches: The Forerunner of the AP.

    ERIC Educational Resources Information Center

    Schwarzlose, Richard A.

    The origin of the Associated Press (AP) lies in the early cooperative news gathering efforts of the editors of several New York newspapers. As early as May 1846, these editors were "pooling" their energies in response to newly developed modes of communication--the wire and wireless telegraph and the trans-oceanic steamship mail services. The…

  7. APS Science 2006.

    SciTech Connect

    Gibson, J. M.; Fenner, R. B.; Long, G.; Borland, M.; Decker, G.

    2007-05-24

    In my five years as the Director of the Advanced Photon Source (APS), I have been fortunate to see major growth in the scientific impact from the APS. This year I am particularly enthusiastic about prospects for our longer-term future. Every scientific instrument must remain at the cutting edge to flourish. Our plans for the next generation of APS--an APS upgrade--got seriously in gear this year with strong encouragement from our users and sponsors. The most promising avenue that has emerged is the energy-recovery linac (ERL) (see article on page xx), for which we are beginning serious R&D. The ERL{at}APS would offer revolutionary performance, especially for x-ray imaging and ultrafast science, while not seriously disrupting the existing user base. I am very proud of our accelerator physics and engineering staff, who not only keep the current APS at the forefront, but were able to greatly impress our international Machine Advisory Committee with the quality of their work on the possible upgrade option (see page xx). As we prepare for long-term major upgrades, our plans to develop and optimize all the sectors at APS in the near future are advancing. Several new beamlines saw first light this year, including a dedicated powder diffraction beamline (11-BM), two instruments for inelastic x-ray scattering at sector 30, and the Center for Nanoscale Materials (CNM) Nanoprobe beamline at sector 26. Our partnership in the first x-ray free-electron laser (LCLS) to be built at Stanford contributes to revolutionary growth in ultrafast science (see page xx), and we are developing a pulse chirping scheme to get ps pulses at sector 7 of the APS within a year or so. In this report, you will find selected highlights of scientific research at the APS from calendar year 2006. The highlighted work covers diverse disciplines, from fundamental to applied science. In the article on page xx you can see the direct impact of APS research on technology. Several new products have emerged from work at the APS, to complement the tremendous output of work in basic science, which often has payoff in technology but over decades rather than years. Highlights in this report also reflect the relevance of APS work to Department of Energy missions, for example a route to more efficient fuel cells (page xx mr-88-073113) addresses the energy challenge, and natural approaches to cleaning up the environment.

  8. The Associated Press Stylebook and Libel Manual. Fully Revised and Updated.

    ERIC Educational Resources Information Center

    Goldstein, Norm, Ed.

    Noting that more people write for The Associated Press (AP) than for any single newspaper in the world and that its style defines clear writing, this book presents more than 5000 entries that present AP's rules on grammar, spelling, punctuation and usage, with extra sections about reporting business and sports. The book, considered essential for…

  9. Letting The NASA Press Engine Work For You

    NASA Technical Reports Server (NTRS)

    Weaver, Kimberly

    2006-01-01

    You have an amazing result based on NASA data or a NASA Mission; you have written your seminal paper and submitted it to your favorite journal. You believe it has press potential and maybe you've even gotten help from your PR folks in writing a press release. Now you would really like NASA to issue this as a press release. But how do you do that? This presentation will illustrate the steps required to engage NASA in helping promote your story. What are NASA's requirements for newsworthiness? Should your news be released as a web feature story or in the local media? Does your news rise to the level of a full-blown press conference or will it be a media teleconference? How do you obtain approval for a NASA press event? Once your result is scheduled to be issued as a press release, how can you improve your chances of getting the best possible coverage for your story? I will discuss the NASA press process and suggest how to consider factors like timing, working with your collaborating institutions in an efficient way, and not letting the cat out of the bag until the press event.

  10. APS Science 2009.

    SciTech Connect

    Gibson, J. M; Mills, D. M.; Gerig, R.

    2010-05-01

    It is my pleasure to introduce the 2009 annual report of the Advanced Photon Source. This was a very good year for us. We operated with high reliability and availability, despite growing problems with obsolete systems, and our users produced a record output of publications. The number of user experiments increased by 14% from 2008 to more than 3600. We congratulate the recipients of the 2009 Nobel Prize in Chemistry-Venkatraman Ramakrishnan (Cambridge Institute for Medical Research), Thomas Steitz (Yale University), and Ada Yonath (Weizmann Institute) - who did a substantial amount of this work at APS beamlines. Thanks to the efforts of our users and staff, and the ongoing counsel of the APS Scientific Advisory Committee, we made major progress in advancing our planning for the upgrade of the APS (APS-U), producing a proposal that was positively reviewed. We hope to get formal approval in 2010 to begin the upgrade. With advocacy from our users and the support of our sponsor, the Office of Basic Energy Sciences in the Department of Energy (DOE) Office of Science, our operating budgets have grown to the level needed to more adequately staff our beamlines. We were also extremely fortunate to have received $7.9 M in American Recovery and Reinvestment Act ('stimulus') funding to acquire new detectors and improve several of our beamlines. The success of the new Linac Coherent Light Source at Stanford, the world's first x-ray free-electron laser, made us particularly proud since the undulators were designed and built by the APS. Among other highlights, we note that more than one-quarter of the 46 Energy Frontier Research Centers, funded competitively across the U.S. in 2009 by the DOE, included the Advanced Photon Source in their proposed work, which shows that synchrotron radiation, and the APS in particular, are central to energy research. While APS research covers everything from fundamental to applied science (reflected by the highlights in this report), the challenge of sustainable energy provides an opportunity for expanded involvement with industrial research. We were privileged to recruit several outstanding new leaders at the APS. Linda Young, from Argonne's Chemical Sciences Division, became the new Director of the X-ray Science Division (XSD). Chris Jacobsen (from Stony Brook University) has been added to Linda's team as an XSD Associate Division Director, joining George Srajer. Alexander (Sasha) Zholents (formerly of Berkeley Lab) became Director of the Accelerator Systems Division. Sasha is the inventor of the short-pulse x-ray scheme that we plan to implement in the APS-U to obtain very high average brightness, broadband, 1-ps x-ray pulses. Walter Lowe (formerly of Howard University) has taken a new position as senior advisor for outreach and development of the user community. Walter's role is to increase the diversity of the user community (with diversity read broadly to include users, institutions, and technical disciplines that are underrepresented at APS). Walter is also leading an effort to increase access for industrial users. I am confident that we have in place a great team to help our users and the APS take fullest advantage of the APS-U opportunity. In planning with users for the proposed APS-U, we focused on the need to study 'real materials under real conditions in real time' on spatial and temporal scales unavailable today. Only by studying materials as they are made-or as they perform-in difficult environments can we solve the grand challenge of higher-performance, sustainable materials for energy and health. The proposed APS-U will improve the brightness of penetrating x-rays produced by the APS over 100 times, and support our efforts in developing state-of-the-art instruments to address these challenges.

  11. Building Reading, Writing and Analysis in the AP U.S. History Classroom

    ERIC Educational Resources Information Center

    Heller, Stephen; Stacy, Jason

    2013-01-01

    The building of historical thinking skills has historically been a lonely endeavor for AP U.S. history teachers. Many often generate their own pedagogy, perhaps modified from an AP workshop or generally gleaned from released exam essay questions. However, as currently scheduled, in 2014, the AP U.S. history exam will undergo a redesign that will…

  12. Advancing beyond AP Courses

    ERIC Educational Resources Information Center

    Hammond, Bruce G.

    2009-01-01

    A quiet revolution is picking up steam in the nation's private secondary schools, with broad implications for college admissions and for teaching and learning on both sides of the transition from high school to college. About 50 of the nation's leading college-preparatory schools have opted out of the College Board's Advanced Placement (AP)

  13. Press-On Optics

    ERIC Educational Resources Information Center

    Thorson, Jon C.

    1972-01-01

    The article discusses the design, application, and clinical uses of press-on optics which are descirbed as 1 millimeter thick, flexible lenses or prisms that may be produced in virtually any desired plus or minus dioptric power as ophthalmic lenses, or in any range of usable prism diopter power. (GW)

  14. Optically Aligned Drill Press

    NASA Technical Reports Server (NTRS)

    Adderholdt, Bruce M.

    1994-01-01

    Precise drill press equipped with rotary-indexing microscope. Microscope and drill exchange places when turret rotated. Microscope axis first aligned over future hole, then rotated out of way so drill axis assumes its precise position. New procedure takes less time to locate drilling positions and produces more accurate results. Apparatus adapted to such other machine tools as milling and measuring machines.

  15. Meet the Press

    ERIC Educational Resources Information Center

    Quick, Brian L.

    2004-01-01

    Objective: To field questions from a room of students simulating a press conference. Type of speech: Impromptu. Point value: 10 participation points. To receive all 10 points, students must (1) address three questions from the lectern and ask three questions from their seat (3 points), (2) respond thoroughly to each question by providing a…

  16. Drill Press Work Sample.

    ERIC Educational Resources Information Center

    Shawsheen Valley Regional Vocational-Technical High School, Billerica, MA.

    This manual contains a work sample intended to assess a handicapped student's interest in and to screen interested students into a training program in basic machine shop I. (The course is based on the entry level of the drill press operator.) Section 1 describes the assessment, correlates the work performed and worker traits required for…

  17. APS Science 2007.

    SciTech Connect

    Not Available

    2008-05-30

    This report provides research highlights from the Advanced Photon Source (APS). Although these highlights represent less than 10% of the published work from the APS in 2007, they give a flavor of the diversity and impact of user research at the facility. In the strategic planning the aim is to foster the growth of existing user communities and foresee new areas of research. This coming year finds the APS engaged in putting together, along with the users, a blueprint for the next five years, and making the case for a set of prioritized investments in beamlines, the accelerator, and infrastructure, each of which will be transformational in terms of scientific impact. As this is written plans are being formulated for an important user workshop on October 20-21, 2008, to prioritize strategic plans. The fruit from past investments can be seen in this report. Examples include the creation of a dedicated beamline for x-ray photon correlation spectroscopy at Sector 8, the evolution of dedicated high-energy x-ray scattering beamlines at sectors 1 and 11, a dedicated imaging beamline at Sector 32, and new beamlines for inelastic scattering and powder diffraction. A single-pulse facility has been built in collaboration with Sector 14 (BioCARS) and Phil Anfinrud at the National Institutes of Health, which will offer exceptionally high flux for single-pulse diffraction. The nanoprobe at Sector 26, built and operated jointly by the Argonne Center for Nanoscale Materials and the X-ray Operations and Research (XOR) section of the APS X-ray Science Division, has come on line to define the state of the art in nanoscience.

  18. Supercomputing and AP stars

    NASA Astrophysics Data System (ADS)

    Stift, M. J.

    1998-04-01

    Certain problems in the field of stellar atmospheres, polarised radiative transfer and magnetic field diagnostics cannot be addressed by means of traditional sequential programming techniques because CPU times become prohibitive on even the fastest single processor machines when realistic physics and accurate numerical methods are employed. This contribution discusses the question of what kind of supercomputing approach is best suited for the modelling of Ap stars, pointing out the superiority of parallel computing with Ada95 over High Performance Fortran in all of the above-mentioned fields.

  19. 55. QUARRY TILE CUTTERS, SECOND FLOOR, NORTH WING. WORKERS PRESSED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    55. QUARRY TILE CUTTERS, SECOND FLOOR, NORTH WING. WORKERS PRESSED THE CUTTERS INTO SLABS OF CLAY, LIFTED THEM ONTO DRYING BOARDS AND PRESSED THE PLUNGERS TO RELEASE THE CUT TILES. REPRODUCTIONS CUTTERS ARE NOT USED IN PRODUCTION. WOODEN FORMS FOR PRODUCING CLAY SLABS WITH ROLLING PINS REST AGAINST THE WALL. - Moravian Pottery & Tile Works, Southwest side of State Route 313 (Swamp Road), Northwest of East Court Street, Doylestown, Bucks County, PA

  20. The Clathrin Adaptor Complex AP-1 Binds HIV-1 and MLV Gag and Facilitates Their Budding

    PubMed Central

    Camus, Grgory; Segura-Morales, Carolina; Molle, Dorothee; Lopez-Vergs, Sandra; Begon-Pescia, Christina; Cazevieille, Chantal; Schu, Peter; Bertrand, Edouard

    2007-01-01

    Retroviral assembly is driven by Gag, and nascent viral particles escape cells by recruiting the machinery that forms intralumenal vesicles of multivesicular bodies. In this study, we show that the clathrin adaptor complex AP-1 is involved in retroviral release. The absence of AP-1? obtained by genetic knock-out or by RNA interference reduces budding of murine leukemia virus (MLV) and HIV-1, leading to a delay of viral propagation in cell culture. In contrast, overexpression of AP-1? enhances release of HIV-1 Gag. We show that the AP-1 complex facilitates retroviral budding through a direct interaction between the matrix and AP-1?. Less MLV Gag is found associated with late endosomes in cells lacking AP-1, and our results suggest that AP-1 and AP-3 could function on the same pathway that leads to Gag release. In addition, we find that AP-1 interacts with Tsg101 and Nedd4.1, two cellular proteins known to be involved in HIV-1 and MLV budding. We propose that AP-1 promotes Gag release by transporting it to intracellular sites of active budding, and/or by facilitating its interactions with other cellular partners. PMID:17538020

  1. CIDER PRESS, LOOKING SOUTHEAST ACROSS THE SCHUYLKILL RIVER. THIS PRESS, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CIDER PRESS, LOOKING SOUTHEAST ACROSS THE SCHUYLKILL RIVER. THIS PRESS, CARVED OUT OF A LARGE BOULDER AT THE RIVERS EDGE, PROBABLY DATES FROM THE LIFETIME OF JOHN BARTRAM, IF NOT TO THE SWEDISH SETTLERS BEFORE HIM. THE IRON FENCE IS A NINETEENTH-CENTURY ADDITION - John Bartram House & Garden, 54th Street & Lindbergh Boulevard, Philadelphia, Philadelphia County, PA

  2. PRESS SHOP. SEVEN BLISS PRESSES STAMP OUT A VARIETY OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PRESS SHOP. SEVEN BLISS PRESSES STAMP OUT A VARIETY OF CARTRIDGE AND SHELL CASINGS. THIS DEPARTMENT WAS TRANSFORMED FROM A MONEY-LOSING OPERATION TO A PROFIT CENTER UNDER THE FIRST WORKER-MANAGED QUALITY CIRCLE IN THE PLANT. - American Brass Foundry, 70 Sayre Street, Buffalo, Erie County, NY

  3. AP-42 REVISION: COKE OVENS

    EPA Science Inventory

    The document "Compilation of Air Pollutant Emission Factors" (AP-42) has been published by the U. S. Environmental Protection Agency (EPA) since 1972. Supplements to AP-42 have been routinely published to add new emission source categories and to update existing emission factor...

  4. Thermal Decomposition Characteristics of Orthorhombic Ammonium Perchlorate (o-AP) and an 0-AP/HTPB-Based Propellant

    SciTech Connect

    BEHRENS JR.,RICHARD; MINIER,LEANNA M.G.

    1999-10-25

    A study to characterize the low-temperature reactive processes for o-AP and an AP/HTPB-based propellant (class 1.3) is being conducted in the laboratory using the techniques of simultaneous thermogravimetric modulated beam mass spectrometry (STMBMS) and scanning electron microscopy (SEM). The results presented in this paper are a follow up of the previous work that showed the overall decomposition to be complex and controlled by both physical and chemical processes. The decomposition is characterized by the occurrence of one major event that consumes up to {approx}35% of the AP, depending upon particle size, and leaves behind a porous agglomerate of AP. The major gaseous products released during this event include H{sub 2}O, O{sub 2}, Cl{sub 2}, N{sub 2}O and HCl. The recent efforts provide further insight into the decomposition processes for o-AP. The temporal behaviors of the gas formation rates (GFRs) for the products indicate that the major decomposition event consists of three chemical channels. The first and third channels are affected by the pressure in the reaction cell and occur at the surface or in the gas phase above the surface of the AP particles. The second channel is not affected by pressure and accounts for the solid-phase reactions characteristic of o-AP. The third channel involves the interactions of the decomposition products with the surface of the AP. SEM images of partially decomposed o-AP provide insight to how the morphology changes as the decomposition progresses. A conceptual model has been developed, based upon the STMBMS and SEM results, that provides a basic description of the processes. The thermal decomposition characteristics of the propellant are evaluated from the identities of the products and the temporal behaviors of their GFRs. First, the volatile components in the propellant evolve from the propellant as it is heated. Second, the hot AP (and HClO{sub 4}) at the AP-binder interface oxidize the binder through reactions that preferentially strip the hydrogen from the binder and yield HCl and H{sub 2}O with some oxidation of the carbon from the binder. Third, the o-AP in the propellant decomposes in the same manner as in neat o-AP. Finally, AP-derived gaseous products interact with other ingredients in the propellant.

  5. NOS1AP in schizophrenia.

    PubMed

    Brzustowicz, Linda M

    2008-04-01

    NOS1AP is an attractive candidate gene for schizophrenia susceptibility. Linkage and association studies from multiple samples drawn from different populations indicate that a schizophrenia susceptibility gene is located in the region of chromosome 1 containing NOS1AP. Increased NOS1AP expression is observed in postmortem samples from individuals with schizophrenia. NOS1AP binds to neuronal nitric oxide synthase and synapsin, other candidate genes for schizophrenia, and may disrupt signal transduction through the N-methyl d-aspartate receptor complex, leading to hypofunctioning of that system. In this review, I present the evidence supporting NOS1AP as a schizophrenia susceptibility gene, with a focus on explaining the strengths and weaknesses of the evidence obtained from each type of study that has been conducted. PMID:18474209

  6. APS controls overview

    SciTech Connect

    1996-02-01

    The APS accelerator control system described in this report is a distributed system consisting of operator interfaces, a network, and interfaces to hardware. The operator interface is a UNIX-based workstation with an X-windows graphical user interface. The workstation may be located at any point on the facility network and maintain full functionality. The user has the ability to generate and alter control displays and to access the alarm handler, the archiver, interactive control programs, custom code, and other tools. The TCP/EP networking protocol has been selected as the underlying protocol for the control system network. TCP/EP is a commercial standard and readily available from network hardware vendors. Its implementation is independent of the particular network medium selected to implement the controls network. In the development environment copper Ethernet is the network medium; however, in the actual implementation a fiber-based system using hub technology will be utilized. The function of the network is to provide a generalized communication path between the host computers, operator workstations, input/output crates, and other hardware that comprise the control system.

  7. The CIA and the Press.

    ERIC Educational Resources Information Center

    Carvalho, Bernardo A.

    The involvement of the Central Intelligence Agency (CIA) with both United States and foreign news media has been recorded in numerous publications. This report reviews the important aspects of the CIA-press relationships as they have appeared in print and discusses the implications of these relationsihps for the credibility of the press. Media

  8. The CIA and the Press.

    ERIC Educational Resources Information Center

    Carvalho, Bernardo A.

    The involvement of the Central Intelligence Agency (CIA) with both United States and foreign news media has been recorded in numerous publications. This report reviews the important aspects of the CIA-press relationships as they have appeared in print and discusses the implications of these relationsihps for the credibility of the press. Media…

  9. Bridging the Small Press Gap.

    ERIC Educational Resources Information Center

    Hoffert, Barbara; Kinsella, Bridget

    1996-01-01

    Discusses the emergence of small presses as viable competitors in the publishing industry as a result of their growing use of trade associations, distributors, and wholesalers geared towards their particular needs. Through these intermediaries, small press offerings are entering the library market in increasing numbers. A sidebar presents contact…

  10. A comparison of impulse drying to double felted pressing on pilot- scale shoe presses and roll presses

    SciTech Connect

    Orloff, D.I.

    1992-08-01

    Pilot-scale shoe press and roll press experiments have been conducted to compare impulse drying and double felted pressing. Both ceramic coated and Beloit Type C press rolls have been evaluated. The experiments show that impulse drying can provide significantly higher outgoing solids than double felled pressing at the same impulse. For example, at an impulse of 0.234 MPa seconds (34 psi seconds), sheets at an ingoing solids of 52% were impulse dried (using the Beloit Type C press roll) to 68% solids while optimized double felled pressing could only yield press dryness of, at most, 60%.

  11. Stabilization of clathrin coats by the core of the clathrin-associated protein complex AP-2.

    PubMed

    Matsui, W; Kirchhausen, T

    1990-12-01

    AP-2 is the class of clathrin-associated protein complex found in coated vesicles derived from the plasma membrane of eukaryotic cells. We demonstrate here, using a chemical method, that an AP-2 complex is an asymmetric structure consisting of one large alpha chain, one large beta chain, one medium AP50 chain, and one small AP17 chain. The complex has been shown to contain a core and two appendages. The AP core includes the small AP17 and the medium AP50 chains together with the amino-terminal domains of the large alpha and beta chains. One appendage corresponds to the carboxy-terminal domain of the beta chain. We find that as in the case of the beta chains, the carboxy-terminal portion of the alpha chains is an independently folded domain corresponding to the second appendage. We use limited tryptic proteolysis of clathrin/AP-2 coats to show the release of the appendages from the interior of the coats and the retention of the AP core by the remaining clathrin lattice. In addition, we find that the AP core stabilizes the coat and prevents its depolymerization. These results are consistent with the proposal that the AP core contains the binding site(s) for clathrin, while the alpha- and beta-chain appendages interact with membrane components of coated pits and coated vesicles. PMID:2125494

  12. APS Education and Diversity Efforts

    NASA Astrophysics Data System (ADS)

    Prestridge, Katherine; Hodapp, Theodore

    2015-11-01

    American Physical Society (APS) has a wide range of education and diversity programs and activities, including programs that improve physics education, increase diversity, provide outreach to the public, and impact public policy. We present the latest programs spearheaded by the Committee on the Status of Women in Physics (CSWP), with highlights from other diversity and education efforts. The CSWP is working to increase the fraction of women in physics, understand and implement solutions for gender-specific issues, enhance professional development opportunities for women in physics, and remedy issues that impact gender inequality in physics. The Conferences for Undergraduate Women in Physics, Professional Skills Development Workshops, and our new Professional Skills program for students and postdocs are all working towards meeting these goals. The CSWP also has site visit and conversation visit programs, where department chairs request that the APS assess the climate for women in their departments or facilitate climate discussions. APS also has two significant programs to increase participation by underrepresented minorities (URM). The newest program, the APS National Mentoring Community, is working to provide mentoring to URM undergraduates, and the APS Bridge Program is an established effort that is dramatically increasing the number of URM PhDs in physics.

  13. Multicomponent Implant Releasing Dexamethasone

    NASA Astrophysics Data System (ADS)

    Nikkola, L.; Vapalahti, K.; Ashammakhi, N.

    2008-02-01

    Several inflammatory conditions are usually treated with corticosteroids. There are various problems like side effects with traditional applications of steroids, e.g. topical, or systemic routes. Local drug delivery systems have been studied and developed to gain more efficient administration with fewer side effects. Earlier, we reported on developing Dexamethasone (DX) releasing biodegradable fibers. However, their drug release properties were not satisfactory in terms of onset of drug release. Thus, we assessed the development of multicomponent (MC) implant to enhance earlier drug release from such biodegradable fibers. Poly (lactide-co-glycolide) (PLGA) and 2 wt-% and 8 wt-% DX were compounded and extruded with twin-screw extruder to form of fibers. Some of the fibers were sterilized to obtain a change in drug release properties. Four different fiber classes were studied: 2 wt-%, 8 wt-%, sterilized 2 wt-%, and sterilized 8 wt-%. 3×4 different DX-releasing fibers were then heat-pressed to form one multicomponent rod. Half of the rods where sterilized. Drug release was measured from initial fibers and multicomponent rods using a UV/VIS spectrometer. Shear strength and changes in viscosity were also measured. Drug release studies showed that drug release commenced earlier from multicomponent rods than from component fibers. Drug release from multicomponent rods lasted from day 30 to day 70. The release period of sterilized rods extended from day 23 to day 57. When compared to the original component fibers, the drug release from MC rods commenced earlier. The initial shear strength of MC rods was 135 MPa and decreased to 105 MPa during four weeks of immersion in phosphate buffer solution. Accordingly, heat pressing has a positive effect on drug release. After four weeks in hydrolysis, no disintegration was observed.

  14. AP Human Geography and Success on the AP Test

    ERIC Educational Resources Information Center

    Roncone, John; Newhalfen, Nate

    2013-01-01

    Classroom projects that explore culture and globalization enhance the curriculum and help students see how geography directly connects to their lives. These authors contend that a project-based approach can supplement the teaching of an AP Human Geography course, and visualize this course as an essential tool for students to truly understand how…

  15. Low Earth orbit assessment of proton anisotropy using AP8 and AP9 trapped proton models.

    PubMed

    Badavi, Francis F; Walker, Steven A; Santos Koos, Lindsey M

    2015-04-01

    The completion of the International Space Station (ISS) in 2011 has provided the space research community with an ideal evaluation and testing facility for future long duration human activities in space. Ionized and secondary neutral particles radiation measurements inside ISS form the ideal tool for validation of radiation environmental models, nuclear reaction cross sections and transport codes. Studies using thermo-luminescent detectors (TLD), tissue equivalent proportional counter (TPEC), and computer aided design (CAD) models of early ISS configurations confirmed that, as input, computational dosimetry at low Earth orbit (LEO) requires an environmental model with directional (anisotropic) capability to properly describe the exposure of trapped protons within ISS. At LEO, ISS encounters exposure from trapped electrons, protons and geomagnetically attenuated galactic cosmic rays (GCR). For short duration studies at LEO, one can ignore trapped electrons and ever present GCR exposure contributions during quiet times. However, within the trapped proton field, a challenge arises from properly estimating the amount of proton exposure acquired. There exist a number of models to define the intensity of trapped particles. Among the established trapped models are the historic AE8/AP8, dating back to the 1980s and the recently released AE9/AP9/SPM. Since at LEO electrons have minimal exposure contribution to ISS, this work ignores the AE8 and AE9 components of the models and couples a measurement derived anisotropic trapped proton formalism to omnidirectional output from the AP8 and AP9 models, allowing the assessment of the differences between the two proton models. The assessment is done at a target point within the ISS-11A configuration (circa 2003) crew quarter (CQ) of Russian Zvezda service module (SM), during its ascending and descending nodes passes through the south Atlantic anomaly (SAA). The anisotropic formalism incorporates the contributions of proton narrow pitch angle (PA) and east-west (EW) effects. Within SAA, the EW anisotropy results in different level of exposure to each side of the ISS Zvezda SM, allowing angular evaluation of the anisotropic proton spectrum. While the combined magnitude of PA and EW effects at LEO depends on a multitude of factors such as trapped proton energy, orientation and altitude of the spacecraft along the velocity vector, this paper draws quantitative conclusions on the combined anisotropic magnitude differences within ISS SM target point between AP8 and AP9 models. PMID:26177846

  16. Apollo 13 Facts: Press Conference

    NASA Technical Reports Server (NTRS)

    2001-01-01

    Flight Director Gene Krantz gives an overview of the Apollo 13 mission as corrections are made in the power down checklist, passive thermal control, and orbital burns after the spacecraft runs into problems. He then answers questions from the press with the help of Tony England, Bill Peters, and Dick Thorson. Footage then shows newspaper headlines 'We're Not Concerned' and 'Getting Ready to Land' as people watch televisions to see if the astronauts landed safely. The press conference section of this video has sound, the headlines section does not.

  17. AP Geography, Environmental Science Thrive

    ERIC Educational Resources Information Center

    Robelen, Erik W.

    2012-01-01

    Geography may not be particularly known as a hot topic among today's students--even some advocates suggest it suffers from an image problem--but by at least one measure, the subject is starting to come into its own. Across more than 30 topics covered in the Advanced Placement (AP) program, participation in geography is rising faster than any…

  18. AP Geography, Environmental Science Thrive

    ERIC Educational Resources Information Center

    Robelen, Erik W.

    2012-01-01

    Geography may not be particularly known as a hot topic among today's students--even some advocates suggest it suffers from an image problem--but by at least one measure, the subject is starting to come into its own. Across more than 30 topics covered in the Advanced Placement (AP) program, participation in geography is rising faster than any

  19. NATIONAL ACADEMY PRESS WEB SITE

    EPA Science Inventory

    The National Academy Press is the publisher for the National Academy of Sciences, the National Academy of Engineering, the Institute of Medicine, and the National Research Council. Through this web site, you have access to a virtual treasure trove of books, reports and publicatio...

  20. Gifted Education Press Quarterly, 1995.

    ERIC Educational Resources Information Center

    Fisher, Maurice D., Ed.

    1995-01-01

    This document consists of the four issues of the newsletter "Gifted Education Press Quarterly" published during 1995. This newsletter addresses issues in the education of gifted children and youth. The major articles are: (1) "Using Today's Technology: Parents Can Help Challenge Gifted Children" (Adrienne O'Neill); (2) "Outcomes-Based Education…

  1. Mars Observer Press Conference JPL

    NASA Technical Reports Server (NTRS)

    1993-01-01

    The Mars Observer mission spacecraft was primarily designed for exploring Mars and the Martian environment. The Mars Observer was launched on September 25, 1992. The spacecraft was lost in the vicinity of Mars on August 21, 1993 when the spacecraft began its maneuvering sequence for Martian orbital insertion. This videotape shows a press briefing, held after the spacecraft had not responded to attempts to communicate with it, to explain to the press the problems and the steps that were being taken to re-establish communication with the spacecraft. The communications had been shutdown prior to the orbital insertion burn to protect the instruments. At the time of the press conference, the communications system was still not operational, and attempts were being made to re-establish communication. Bob McMillan of the Public Affairs Office at JPL gives the initial announcement of the continuing communication problem with the spacecraft. Mr. McMillan introduces William Piotrowski, acting director of solar system exploration, who reiterates that there is indeed no communication with the Observer spacecraft. He is followed by Glenn Cunningham, the Project Manager of the Mars Observer who speaks about the attempts to re-establish contact. Mr. Cunningham is followed by Satenios Dallas, the Mission Manager for the Mars Observer Project, who speaks about the sequence of events leading up to the communication failure, and shows an animated video presenting the orbital insertion maneuvers. The briefing was then opened up for questions from the assembled press, both at JPL and at the other NASA Centers. The questions are about the possible reasons for the communication failure, and the attempts to restore communications with the spacecraft. Dr. Arden L. Albee, chief scientist for the Mars Observer Mission, joins the other panel members to answer questions. At the end of the press briefing the animation of the Mars orbital insertion is shown again.

  2. ASSESSING CHEMICAL RELEASES AND WORKER EXPOSURES FROM A FILTERPRESS

    EPA Science Inventory

    Chemical releases and worker exposures associated with the filtration of an industrial wastewater sludge were characterized. The filter was a recessed chamber filter press with an open filtrate discharge system. Chemical releases and worker exposures for a selected chemical were ...

  3. Galileo Probe: Spacecraft Mission to Jupiter Press Release

    NASA Technical Reports Server (NTRS)

    1989-01-01

    This video is a compilation of three short videos related to the Galileo mission. The first section shows animation of the descent of the Galileo probe into the atmosphere of Jupiter. It includes cutaway views of the atmosphere showing the different layers. This descent will represent the first entry into the atmosphere of an outer planet in our solar system. A second section shows some live shots of the development and drop chute tests of the Galileo spacecraft. A third section is an animation that shows the Probe mission. It shows visualizations from the launch, including the Venus flyby, the separation of the probe and the orbiter, and the trajectory of the planetary arrival. It also shows the descent of the probe into the atmosphere.

  4. An Investigation into Managers' Language Use in Earnings Press Releases

    ERIC Educational Resources Information Center

    Riley, Tracey Jean

    2011-01-01

    For years, researchers have examined financial data in corporate earnings announcements and their influence on market participants. More recently, a body of research has been developing recognizing the impact of narrative disclosures and managers' deliberate language choices. However, no prior studies have investigated those language choices of…

  5. Managing Pesticide Resistance in Potato Health Management, ed. D. Johnson. APS Press

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Pesticides exert a selection pressure on pest populations and pests that are not controlled may produce progeny with genetic resistance to the pesticide. Pesticide classification systems based on site/mode of action have been developed and knowing a pesticides’s mode/site of action is key to planni...

  6. Managing Weeds in Potato Health Management, ed. D. Johnson. APS Press

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Weeds must be managed throughout the entire crop rotation to optimize potato tuber yield and quality. Understanding factors that promote weed species and allow them to persist in crop rotations is key to designing cropping systems that discourage and reduce the impact of weeds. Weeds can be best man...

  7. Applying Pesticides in Potato Health Management, ed. D. Johnson. APS Press

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Pesticides are an important component of most management programs for nematodes, diseases, weeds, and insects that impact yield and/or quality in potatoes. The appropriate pesticide, correct timing of application, effective rate, and appropriate method of application must be selected for effective p...

  8. Preparing Students for the AP Psychology Exam

    ERIC Educational Resources Information Center

    Whitlock, Kristin

    2013-01-01

    The Advanced Placement Psychology exam is one of the fastest growing exams offered by the College Board. The average percent of change in the number of students taking this exam over the past five years is 12.4%. With 238,962 students taking the exam in 2013, the AP Psychology exam is the sixth largest exam, surpassing AP Biology and AP World…

  9. An AP Calculus Classroom Amusement Park

    ERIC Educational Resources Information Center

    Ferguson, Sarah

    2016-01-01

    Throughout the school year, AP Calculus teachers strive to teach course content comprehensively and swiftly in an effort to finish all required material before the AP Calculus exam. As early May approaches and the AP Calculus test looms, students and teachers nervously complete lessons, assignments, and assessments to ensure student preparation.…

  10. Preparing Students for the AP Psychology Exam

    ERIC Educational Resources Information Center

    Whitlock, Kristin

    2013-01-01

    The Advanced Placement Psychology exam is one of the fastest growing exams offered by the College Board. The average percent of change in the number of students taking this exam over the past five years is 12.4%. With 238,962 students taking the exam in 2013, the AP Psychology exam is the sixth largest exam, surpassing AP Biology and AP World

  11. 7 CFR 58.421 - Press.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... openings readily cleanable. The pressure device shall be the continuous type. Press cloths shall be maintained in good repair and in a sanitary condition. Single service press cloths shall be used only once....

  12. 7 CFR 58.421 - Press.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... openings readily cleanable. The pressure device shall be the continuous type. Press cloths shall be maintained in good repair and in a sanitary condition. Single service press cloths shall be used only once....

  13. A biochemical study of hydroxyapatite crystal induced enzyme release from neutrophils.

    PubMed Central

    Elferink, J G; Deierkauf, M

    1987-01-01

    Addition of hydroxyapatite (HyAp) microcrystals to human neutrophils results in exocytosis of specific granules, measured as lysozyme release, and plasma membrane damage, evident from lactate dehydrogenase (LDH) release. The strong hydrogen acceptor polyvinylpyridine-N-oxide has no effect on enzyme release, but polyanions and negatively charged proteins such as albumin strongly inhibit HyAp induced enzyme release. HyAp crystals cause only slightly less membrane damage in neutrophil cytoplasts than in intact neutrophils. Removal of sialic acid from the cells did not affect HyAp induced enzyme release. Glucose, trapped in negatively charged liposomes, is released by HyAp crystals, whereas the crystals do not release glucose from positively charged liposomes. The results indicate that positive charges located on the HyAp crystals are of predominant importance for the effect of the crystals, and that the lipid part of the membrane might play an important part in the interaction. PMID:2821935

  14. DESIGN AND OPERATION OF BELT FILTER PRESSES

    EPA Science Inventory

    Because early models of belt filter presses (developed from technology associated with the manufacture of paper) performed poorly, improved design and operation procedures for these presses were studied. Belt filter presses form part of a sludge dewatering system, and in terms of...

  15. The Small Book Press: A Cultural Essential.

    ERIC Educational Resources Information Center

    Henderson, Bill

    1984-01-01

    Discussion of small literary book publishers notes works of small-press authors (Thomas Paine, Washington Irving, Walt Whitman, Mark Twain, Upton Sinclair, Anais Nin); today's outstanding presses (Creative Arts Book Company, Persea Books, Full Court Press, Reed and Cannon Company, Tuumba Books); and role of little magazines. Thirty-seven…

  16. Yale University Press: Disseminating "Lux et Veritas"?

    ERIC Educational Resources Information Center

    Parrott, John B.

    2010-01-01

    America's university presses are situated within a network of over one hundred universities, learned societies, and scholarly associations. According to a pamphlet put out by the American Association of University Presses, these presses "make available to the broader public the full range and value of research generated by university faculty."…

  17. The Burger Court and the Press.

    ERIC Educational Resources Information Center

    Higdon, Philip R.

    This report discusses recent cases involving freedom of the press that have been heard before the Burger court of the United States Supreme Court. The report discerns a trend toward treating the press like an ordinary citizen; this is a reversal of the view of the Warren court that the First Amendment creates special rights for the press so that…

  18. Pyrometry in the Multianvil Press: New approach for temperature measurement in large volume press experiments

    NASA Astrophysics Data System (ADS)

    Sanehira, T.; Wang, Y.; Prakapenka, V.; Rivers, M. L.

    2008-12-01

    Temperature measurement in large volume press experiments has been based on thermocouple emf, which has well known problems: unknown pressure dependence of emf [e.g., 1], chemical reaction between thermocouple and other materials, deformation related texture development in the thermocouple wires [2], and so on. Thus, different techniques to measure temperatures in large volume press experiments other than thermocouples are required to measure accurate temperatures under high pressures. Here we report a new development using pyrometry in the multianvil press, where temperatures are derived on the basis of spectral radiometry. Several high pressure runs were conducted using the 1000 ton press with a DIA module installed at 13 ID-D GSECARS beamline at Advanced Photon Source (APS) [3]. The cubic pressure medium, 14 mm edge length, was made of soft-fired pyrophyllite with a graphite furnace. A moissanite (SiC) single crystal was built inside the pressure medium as a window for the thermal emission signal to go through. An MgO disk with 1.0 mm thickness was inserted in a gap between the top of the SiC crystal and thermocouple hot junction. The bottom of the window crystal was in direct contact with the tip of the anvil, which had a 1.5 mm diameter hole drilled all the way through the anvil axis. An optical fiber was inserted in this hole and the open end of fiber was in contact with the SiC crystal. Thermal spectral radiance from the inner cell assembly was obtained via the fiber and recorded by an Ocean Optics HP2000 spectrometer. The system response of spectrometer was calibrated by a tungsten ribbon ramp (OL550S, Optronic Laboratories, Inc.) with standard of spectral radiance. The cell assembly was compressed up to target value of 15 tons and then temperature was increased up to 1573 K. Radiation spectra were mainly obtained above 873 K and typical integration time was 1 ms or 10 ms. Data collection was done in the process of increase and decrease of temperature. In one in-situ X-ray experiment, pressures near the thermocouple were derived from the equations of state for gold [4] or MgO [5], and the pressure values varied up to approximately 1 GPa at various temperatures. Two different calculations were made to infer temperature based on pyrometry. One was made based on Planck radiation function and the other was made by the J-function, which was defined based on the law of Wien [6]. Calculated temperatures above about 1000 K were generally consistent with those obtained from the thermocouple emf. However, below about 1000 K, temperatures based on pyrometry in the process of increase of temperature were way off from those obtained by thermocouple emf. Recent results and future improvements will be discussed. Reference [1] I. C. Getting and G. C. Kennedy J. Appl. Phys., 41, 4552-4562, 1970. [2] J. Li, C. Hadidiacos, H.-K. Mao, Y. Fei and R. J. Hemley High Pressure Research, 23, 389-401, 2003. [3] Y. Wang, M. Rivers, S. Sutton, N. Nishiyama, T. Uchida, T. Sanehira Phys. Earth Planet. Inter. in press. [4] S.-H. Shim, T. S. Duffy and K. Takemura Earth Planet. Sci. Lett., 203, 729-739, 2002. [5] M. Matsui, S. C. Parker and M. Leslie Am. Mineral., 85, 312-316, 2000. [6] T. Yagi and J. Susaki, in High-Pressure Research: Application to Earth and Planetary Sciences, edited by Y. Syono and M. H. Manghnani, pp.51-54, TERRAPUB, Tokyo / AGU, Washington D.C., 1992.

  19. The Melanocortin Agonist AP214 Exerts Anti-Inflammatory and Proresolving Properties

    PubMed Central

    Montero-Melendez, Trinidad; Patel, Hetal B.; Seed, Michael; Nielsen, Søren; Jonassen, Thomas E.N.; Perretti, Mauro

    2011-01-01

    Synthetic and natural melanocortin (MC) peptides afford inhibitory properties in inflammation and tissue injury, but characterization of receptor involvement is still elusive. We used the agonist AP214 to test MC-dependent anti-inflammatory effects. In zymosan peritonitis, treatment of mice with AP214 (400 to 800 μg/kg) inhibited cell infiltration, an effect retained in MC receptor type 1, or MC1, mutant mice but lost in MC3 null mice. In vitro, cytokine release from zymosan-stimulated macrophages was affected by AP214, with approximately 80%, 30%, and 40% reduction in IL-1β, tumor necrosis factor-α, and IL-6, respectively. Inhibition of IL-1β release was retained in MC1 mutant cells but was lost in MC3 null cells. Furthermore, AP214 augmented uptake of zymosan particles and human apoptotic neutrophils by wild-type macrophages: this proresolving property was lost in MC3 null macrophages. AP214 displayed its pro-efferocytotic effect also in vivo. Finally, in a model of inflammatory arthritis, AP214 evoked significant reductions in the clinical score. These results indicate that AP214 elicits anti-inflammatory responses, with a preferential effect on IL-1β release. Furthermore, we describe for the first time a positive modulation of an MC agonist on the process of efferocytosis. In all cases, endogenous MC3 is the receptor that mediates these novel properties of AP214. These findings might clarify the tissue-protective properties of AP214 in clinical settings and may open further development for novel MC agonists. PMID:21703408

  20. AP reclamation and reuse in RSRM propellant

    NASA Technical Reports Server (NTRS)

    Miks, Kathryn F.; Harris, Stacey A.

    1995-01-01

    A solid propellant ingredient reclamation pilot plant has been evaluated at the Strategic Operations of Thiokol Corporation, located in Brigham City, Utah. The plant produces AP wet cake (95 percent AP, 5 percent water) for recycling at AP vendors. AP has been obtained from two standard propellant binder systems (PBAN and HTPB). Analytical work conducted at Thiokol indicates that the vendor-recrystallized AP meets Space Shuttle propellant specification requirements. Thiokol has processed 1-, 5-, and 600-gallon propellant mixes with the recrystallized AP. Processing, cast, cure, ballistic, mechanical, and safety properties have been evaluated. Phillips Laboratory static-test-fired 70-pound and 800-pound BATES motors. The data indicate that propellant processed with reclaimed AP has nominal properties.

  1. Enhanced Antimicrobial Activity of AamAP1-Lysine, a Novel Synthetic Peptide Analog Derived from the Scorpion Venom Peptide AamAP1

    PubMed Central

    Almaaytah, Ammar; Tarazi, Shadi; Abu-Alhaijaa, Ahmad; Altall, Yara; Alshar’i, Nizar; Bodoor, Khaldon; Al-Balas, Qosay

    2014-01-01

    There is great interest in the development of antimicrobial peptides as a potentially novel class of antimicrobial agents. Several structural determinants are responsible for the antimicrobial and cytolytic activity of antimicrobial peptides. In our study, a new synthetic peptide analog, AamAP1-Lysine from the naturally occurring scorpion venom antimicrobial peptide AamAP1, was designed by modifying the parent peptide in order to increase the positive charge and optimize other physico-chemical parameters involved in antimicrobial activity. AamAP1-Lysine displayed potent antibacterial activity against Gram-positive and Gram-negative bacteria. The minimum inhibitory concentration was in the range of 5 to 15 µM with a 10 fold increase in potency over the parent peptide. The hemolytic and antiproliferative activity of AamAP1-Lysine against eukaryotic mammalian cells was minimal at the concentration range needed to inhibit bacterial growth. The antibacterial mechanism analysis indicated that AamAP1-Lysine is probably inducing bacterial cell death through membrane damage and permeabilization determined by the release of β-galactosidase enzyme from peptide treated E. coli cells. DNA binding studies revealed that AamAP1-Lysine caused complete retardation of DNA migration and could display intracellular activities in addition to the membrane permeabilization mode of action reported earlier. In conclusion, AamAP1-Lysine could prove to be a potential candidate for antimicrobial drug development in future studies. PMID:24776889

  2. APS high heat load monochromator

    SciTech Connect

    Lee, W.K.; Mills, D.

    1993-02-01

    This document contains the design specifications of the APS high heat load (HHL) monochromator and associated accessories as of February 1993. It should be noted that work is continuing on many parts of the monochromator including the mechanical design, crystal cooling designs, etc. Where appropriate, we have tried to add supporting documentation, references to published papers, and calculations from which we based our decisions. The underlying philosophy behind performance specifications of this monochromator was to fabricate a device that would be useful to as many APS users as possible, that is, the design should be as generic as possible. In other words, we believe that this design will be capable of operating on both bending magnet and ID beamlines (with the appropriate changes to the cooling and crystals) with both flat and inclined crystal geometries and with a variety of coolants. It was strongly felt that this monochromator should have good energy scanning capabilities over the classical energy range of about 4 to 20 keywith Si (111) crystals. For this reason, a design incorporating one rotation stage to drive both the first and second crystals was considered most promising. Separate rotary stages for the first and second crystals can sometimes provide more flexibility in their capacities to carry heavy loads (for heavily cooled first crystals or sagittal benders of second crystals), but their tuning capabilities were considered inferior to the single axis approach.

  3. Tank 241-AP-106, Grab samples, 6AP-98-1, 6AP-98-2 and 6AP-98-3 Analytical results for the final report

    SciTech Connect

    FULLER, R.K.

    1999-02-23

    This document is the final report for tank 241-AP-106 grab samples. Three grab samples 6AP-98-1, 6AP-98-2 and 6AP-98-3 were taken from riser 1 of tank 241-AP-106 on May 28, 1998 and received by the 222-S Laboratory on May 28, 1998. Analyses were performed in accordance with the ''Compatability Grab Sampling and Analysis Plan'' (TSAP) (Sasaki, 1998) and the ''Data Quality Objectives for Tank Farms Waste Compatability Program (DQO). The analytical results are presented in the data summary report. No notification limits were exceeded. The request for sample analysis received for AP-106 indicated that the samples were polychlorinated biphenyl (PCB) suspects. The results of this analysis indicated that no PCBs were present at the Toxic Substance Control Act (TSCA) regulated limit of 50 ppm. The results and raw data for the PCB analysis are included in this document.

  4. STS-37 Post-flight Crew Press Conference. Part 2

    NASA Technical Reports Server (NTRS)

    1991-01-01

    This NASA Kennedy Space Center video release presents a continuation of the April 19, 1991 STS-37 post-flight crew press conference from Johnson Space Center (JSC). Part 2 of the conference continues the question and answer period of Part 1 with Steven R. Nagel, Commander, Kenneth D. Cameron, Pilot, Jerry L. Ross, Mission Specialist 1, Jay Apt, Mission Specialist 2, and Linda M. Godwin, Mission Specialist 3 fielding questions posed by scientific journalists from JSC and other NASA centers. Topics discussed include: the necessary Extravehicular Activity (EVA) to free the Gamma Ray Observatory high gain antenna, communication between Atlantis and space station MIR, HAM radio contacts with Earth, and EVA contingency planning. Part 1 of the press conference can be found in Report Number NONP-NASA-VT-2000013419.

  5. APS: Lighting up the future

    SciTech Connect

    Potent, V.J.

    1993-09-01

    Work on the Advanced Photon Source (APS) at Argonne National Laboratory (ANL) involves the construction and supporting research and development for a national user facility for synchrotron radiation research in the x-ray region. The facility, when operational in 1997, will provide super-intense x-ray beams for many areas of basic research and will serve the entire US x-ray research community of several thousand users. This paper describes the pertinent features of the design, construction and planned operation of the facility; and the impact quality has had in these areas. In addition, the introduction of several quality management techniques such as total quality management, reliability/availability planning, and user interface are discussed concerning their status and success.

  6. Radiative properties of burning ammonium perchlorate/aluminum pressed pellets

    SciTech Connect

    Taylor, D.M.; Brewster, M.Q.

    1987-01-01

    The spectral intensity emitted at 790 nm during the combustion of pressed pellets composed of ammonium perchlorate (AP) and aluminum has been optically measured. Aluminum mass fraction content was varied from 0.5% to 6.0%. The combustion bomb pressure ranged from the low pressure deflagration limit (near 650 psia) to 1100 psia. Based on the intensity measurements, the effective blackbody emission temperature of the flame was near 2600 K for the 6% Al samples. This figure is well above the local gas temperature (AP monopropellant flame temperature 1400 K) and in excess of the adiabatic flame temperature (1700 K to 2400 K depending on the APAl mass fraction) assuming equilibrium. The higher intensities were attributed to the AlAl/sub 2/O/sub 3/ flame surrounding the molten Al droplets as well as the droplet itself. The measured peak intensity levels were restricted to a thin layer of the flame immediately above the deflagrating surface of the pellet. A two part model of the radiant transport in the flame was developed for comparing the theoretical and measured spectral intensities to estimate the magnitude of the radiative parameters of the burning Al droplets. From this model the optical depth of the Al/sub 2/O/sub 3/ flame envelope surrounding a droplet was estimated. In addition, a range of probable values for optical properties of the aluminum droplets as well as their temperatures were found.

  7. Cold press sintering of simulated lunar basalt

    NASA Technical Reports Server (NTRS)

    Altemir, D. A.

    1993-01-01

    In order to predict the conditions for which the lunar regolith may be adequately sintered, experiments were conducted in which samples of simulated lunar basalt (MLS-1) were pressed at high pressures and then heated in an electric furnace. This sintering process may be referred to as cold press sintering since the material is pressed at room temperature. Although test articles were produced which possessed compressive strengths comparable to that of terrestrial concrete, the cold press sintering process requires very high press pressures and sintering temperatures in order to achieve that strength. Additionally, the prospect of poor internal heat transfer adversely affecting the quality of sintered lunar material is a major concern. Therefore, it is concluded that cold press sintering will most likely be undesirable for the production of lunar construction materials.

  8. Slurry-pressing consolidation of silicon nitride

    NASA Technical Reports Server (NTRS)

    Sanders, William A.; Kiser, James D.; Freedman, Marc R.

    1989-01-01

    A baseline slurry-pressing method for a silicon nitride material is developed. The Si3N4 composition contained 5.8 wt percent SiO2 and 6.4 wt percent Y2O3. Slurry-pressing variables included volume percent solids, application of ultrasonic energy, and pH. Twenty vol percent slurry-pressed material was approximately 11 percent stronger than both 30 vol percent slurry-pressed and dry-pressed materials. The Student's t-test showed the difference to be significant at the 99 percent confidence level. Twenty volume percent (300 h) slurry-pressed test bars exhibited strengths as high as 980 MPa. Large, columnar beta-Si3N4 grains caused failure in the highest strength specimens. The improved strength correlated with better structural uniformity as determined by radiography, optical microscopy, and image analysis.

  9. Slurry-pressing consolidation of silicon nitride

    NASA Technical Reports Server (NTRS)

    Sanders, William A.; Kiser, James D.; Freedman, Marc R.

    1988-01-01

    A baseline slurry-pressing method for a silicon nitride material is developed. The Si3N4 composition contained 5.8 wt percent SiO2 and 6.4 wt percent Y2O3. Slurry-pressing variables included volume percent solids, application of ultrasonic energy, and pH. Twenty vol percent slurry-pressed material was approximately 11 percent stronger than both 30 vol percent slurry-pressed and dry-pressed materials. The Student's t-test showed the difference to be significant at the 99 percent confidence level. Twenty volume percent (300 h) slurry-pressed test bars exhibited strengths as high as 980 MPa. Large, columnar beta-Si3N4 grains caused failure in the highest strength specimens. The improved strength correlated with better structural uniformity as determined by radiography, optical microscopy, and image analysis.

  10. Improving Dryer and Press Efficiencies Through Combustion of Hydrocarbon Emissions

    SciTech Connect

    Sujit Banerjee

    2005-10-31

    Emission control devices on dryers and presses have been legislated into the industry, and are now an integral part of the drying system. These devices consume large quantities of natural gas and electricity and down-sizing or eliminating them will provide major energy savings. The principal strategy taken here focuses on developing process changes that should minimize (and in some cases eliminate) the need for controls. A second approach is to develop lower-cost control options. It has been shown in laboratory and full-scale work that Hazardous Air Pollutants (HAPs) emerge mainly at the end of the press cycle for particleboard, and, by extension, to other prod-ucts. Hence, only the air associated with this point of the cycle need be captured and treated. A model for estimating terpene emissions in the various zones of veneer dryers has been developed. This should allow the emissions to be concentrated in some zones and minimized in others, so that some of the air could be directly released without controls. Low-cost catalysts have been developed for controlling HAPs from dryers and presses. Catalysts conventionally used for regenerative catalytic oxidizers can be used at much lower temperatures for treating press emissions. Fluidized wood ash is an especially inexpensive mate-rial for efficiently reducing formaldehyde in dryer emissions. A heat transfer model for estimating pinene emissions from hot-pressing strand for the manufacture of flakeboard has been constructed from first principles and validated. The model shows that most of the emissions originate from the 1-mm layer of wood adjoining the platen surface. Hence, a simple control option is to surface a softwood mat with a layer of hardwood prior to pressing. Fines release a disproportionate large quantity of HAPs, and it has been shown both theo-retically and in full-scale work that particles smaller than 400 µm are principally responsible. Georgia-Pacific is considering green-screening their furnish at several of their mills in order to remove these particles and reduce their treatment costs.

  11. NASA/MSFC Large Stretch Press Study

    NASA Technical Reports Server (NTRS)

    Choate, M. W.; Nealson, W. P.; Jay, G. C.; Buss, W. D.

    1985-01-01

    The purpose of this study was to: A. assess and document the advantages/disadvantages of a government agency investment in a large stretch form press on the order of 5000 tons capacity (per jaw); B. develop a procurement specification for the press; and C. provide trade study data that will permit an optimum site location. Tasks were separated into four major elements: cost study, user survey, site selection, and press design/procurement specification.

  12. [The press and family planning].

    PubMed

    Abraham De D'ornellas, R

    1987-01-01

    The treatment in the press of family planning hinges on two fundamental factors: the taboo of the leftist groups and the taboo of the Catholic Church, whose head is against abortion under any circumstances. Leftist views insinuate that family planning is the genocidal plan of North American imperialists against the Third World and, in particular, against Latin America. This genocidal plan is supposed to subject poor populations to international schemes. In the press family planning is often treated in a sanctimonious fashion, lumping it together with topics like pornography, sex, and violence. In 1983 the daily newspaper Expreso published a supplement running every week for almost three months about the issue of population, which dealt fairly extensively with such topics as population and housing, education, employment, and urban proliferation, as well as responsible parenthood and child survival. In addition, there was a detailed description of contraceptive methods. In October 1986 another surprising thing happened: the President of Peru talked about the topic of family planning, which at the time was an act of courage. Since then much has changed; the whole world is interested in family planning and certain aspects of population. Since October 1986 more has been published in this domain than during the preceding 20 years. In contrast, the Church reacted differently to this issue: after some initial caution, the conference of Peruvian bishops attacked all methods of modern contraceptives and private institutions of family planning. The information boom in family planning will certainly continue. At the moment this flood of articles and editorials about the issue is an expression of the anxiety of families related to uncontrolled reproduction and the fear of overpopulation in large cities devoid of minimal services. PMID:12281466

  13. ELECTROCHEMICAL CORROSION TESTING OF TANKS 241-AN-102 & 241-AP-107 & 241-AP-108 IN SUPPORT OF ULTRASONIC TESTING

    SciTech Connect

    WYRWAS RB; DUNCAN JB

    2008-11-20

    This report presents the results of the corrosion rates that were measured using electrochemical methods for tanks 241-AN-102 (AN-102), 241-AP-107 (AP 107), and 241-AP-108 (AP-108) performed under test plant RPP-PLAN-38215. The steel used as materials of construction for AN and AP tank farms was A537 Class 1. Test coupons of A537 Class 1 carbon steel were used for corrosion testing in the AN-107, AP-107, and AP-108 tank waste. Supernate will be tested from AN-102, AP-107, and Ap-108. Saltcake testing was performed on AP-108 only.

  14. Coaching Strategies for AP: Building a Successful AP European History Program

    ERIC Educational Resources Information Center

    Fornaciari, Jim

    2014-01-01

    The October 2013 special issue of "Social Education" dealt with almost all AP social studies subjects, but omitted AP European History. This is one of the most fascinating AP subjects for students and teachers alike. In this article, the author shares his experiences since hewas given the responsibility of building his school's…

  15. AP-1A controls secretory granule biogenesis and trafficking of membrane secretory granule proteins

    PubMed Central

    Bonnemaison, Mathilde; Bäck, Nils; Lin, Yimo; Bonifacino, Juan S.; Mains, Richard; Eipper, Betty

    2014-01-01

    The adaptor protein 1A complex (AP-1A) transports cargo between the trans-Golgi network (TGN) and endosomes. In professional secretory cells, AP-1A also retrieves material from immature secretory granules (SGs). The role of AP-1A in SG biogenesis was explored using AtT-20 corticotrope tumor cells expressing reduced levels of the AP-1A μ1A subunit. A two-fold reduction in μ1A resulted in a decrease in TGN cisternae and immature SGs and the appearance of regulated secretory pathway components in non-condensing SGs. Although basal secretion of endogenous SG proteins was unaffected, secretagogue-stimulated release was halved. The reduced μ1A levels interfered with the normal trafficking of carboxypeptidase D (CPD) and peptidylglycine α-amidating monooxygenase-1 (PAM-1), integral membrane enzymes that enter immature SGs. The non-condensing SGs contained POMC products and PAM-1, but not CPD. Based on metabolic labeling and secretion experiments, the cleavage of newly synthesized PAM-1 into PHM was unaltered, but PHM basal secretion was increased in sh-μ1A PAM-1 cells. Despite lacking a canonical AP-1A binding motif, yeast two-hybrid studies demonstrated an interaction between the PAM-1 cytosolic domain and AP-1A. Co-immunoprecipitation experiments with PAM-1 mutants revealed an influence of the luminal domains of PAM-1 on this interaction. Thus, AP-1A is crucial for normal SG biogenesis, function and composition. PMID:25040637

  16. AP Music Theory in Your School.

    ERIC Educational Resources Information Center

    Lucia, Raymond

    1993-01-01

    Asserts that an Advanced Placement (AP) course in music theory offers student musicians opportunities to gain new insight into melody, harmony, and structure. Describes content and teaching methods used in an AP music theory program. Discusses necessary teacher characteristics and maintains that both students and teachers benefit from the course.…

  17. The status of APS, BESSRC, and NEET.

    SciTech Connect

    Ahmad, I.; Dunford, R. W.; Esbensen, H.; Gemmell, D. S.; Kanter, E. P.; Kraessig, B.; Rutt, U.; Southworth, S. H.

    1999-03-10

    We present a brief summary of the current status of the Advanced Photon Source (APS) at Argonne National Laboratory and of the facilities at two of the APS sectors operated by the Basic Energy Sciences Synchrotrons Radiation Center (BESSRC). This is followed by a report on recent measurements at BESSRC on the phenomenon of Nuclear Excitation by Electronic Transition (NEET).

  18. AP-42 ADDITIONS AND REVISIONS - WILDLAND FIRES

    EPA Science Inventory

    This project is aimed at consolidating, selecting, and disseminating the most appropriate data and methods for estimating air emissions from wildfires and prescribed burns. The product will replace a current section of AP-42, but may not take the precise form of an AP-42 secti...

  19. APS-DPP Education and Outreach

    NASA Astrophysics Data System (ADS)

    Correll, Donald

    1998-11-01

    Through its membership and their respectful institutions, the APS-DPP continues to be recognized for its education and outreach efforts. Each year starting with the 1988 DPP annual meeting, DPP and the APS Office of Education have jointly sponsored a "Science Teachers' Day." Beginning in 1994, a companion "Plasma Physics Expo" has been held during the same week of the November meeting. Both events continue to receive uniformly enthusiastic responses from teachers and students who participate. These two events are not only supported financially by APS and APS-DPP but also by APS-DPP member contributions and by contributions of the major plasma physics and fusion research institutions. Recently, the DPP Interdivisional and Public Affairs Committee was re-named the DPP Science Education Committee (see DPP Newsletter, Spring 1998) to reflect the importance that the DPP puts on education and outreach. Nevertheless, as Andrew Sessler, APS President, said in the Education Outreach special insert of the January APS News "We have many education and outreach activities in the areas of K -12 education . . . but very few APS members are aware of what we are doing . . . ." This paper is an attempt to communicate to the DPP members who have not participated in DPP's education and outreach activities a summary of what is being accomplished in this area, what is being planned for the future, and how does one participate in these activities.

  20. Advanced APS Impacts on Vehicle Payloads

    NASA Technical Reports Server (NTRS)

    Schneider, Steven J.; Reed, Brian D.

    1989-01-01

    Advanced auxiliary propulsion system (APS) technology has the potential to both, increase the payload capability of earth-to-orbit (ETO) vehicles by reducing APS propellant mass, and simplify ground operations and logistics by reducing the number of fluids on the vehicle and eliminating toxic, corrosive propellants. The impact of integrated cryogenic APS on vehicle payloads is addressed. In this system, launch propulsion system residuals are scavenged from integral launch propulsion tanks for use in the APS. Sufficient propellant is preloaded into the APS to return to earth with margin and noncomplete scavenging assumed. No propellant conditioning is required by the APS, but ambient heat soak is accommodated. High temperature rocket materials enable the use of the unconditioned hydrogen/oxygen in the APS and are estimated to give APS rockets specific impulse of up to about 444 sec. The payload benefits are quantified and compared with an uprated monomethyl hydrazine/nitrogen tetroxide system in a conservative fashion, by assuming a 25.5 percent weight growth for the hydrogen/oxygen system and a 0 percent weight growth for the uprated system. The combination and scavenging and high performance gives payload impacts which are highly mission specific. A payload benefit of 861 kg (1898 lbm) was estimated for a Space Station Freedom rendezvous mission and 2099 kg (4626 lbm) for a sortie mission, with payload impacts varying with the amount of launch propulsion residual propellants. Missions without liquid propellant scavenging were estimated to have payload penalties, however, operational benefits were still possible.

  1. AP Courses Get Audited for Quality

    ERIC Educational Resources Information Center

    Ashford, Ellie

    2007-01-01

    As the college admissions process has gotten much more competitive, the number of high school students taking Advanced Placement (AP) courses has soared. At the same time, policymakers and education leaders seek to get more minorities and students not on the college track to sign up for AP and other rigorous classes. But as high schools have…

  2. Columbia University Press: Trading on Tradition.

    ERIC Educational Resources Information Center

    Fialkoff, Francine

    1998-01-01

    Columbia University Press's current and future solvency rests on a complex balance of reference, scholarly, and trade titles as well as an innovative collaboration with the library to help guarantee the house's preeminence in the academic community. The Press's strategic approach is described. (Author)

  3. Freedom of the Press vs. Public Access.

    ERIC Educational Resources Information Center

    Schmidt, Benno C., Jr.

    This book surveys the implications of freedom of the press for a constitutionally rooted public right of access to electronic and print media. Part one provides general perspectives on access to the media, including discussions of access in relation to the Supreme Court, to First Amendment history and theory, to current perceptions of the press,…

  4. The Egyptian Press: An Official Fourth Estate.

    ERIC Educational Resources Information Center

    Lawhorne, Clifton O.

    A descriptive study based on Egyptian law, printed sources, and interviews clarifies our picture of the Egyptian Press by examining its status as a constitutionally mandated "Fourth Estate." The constitutional amendment, the resultant Egyptian Press Law, and the "Law Of Shame" (all passed in 1980), are designed to create a heavily controlled press…

  5. The Lily-White University Presses.

    ERIC Educational Resources Information Center

    Shin, Annys

    1996-01-01

    Argues that the university presses are immune from racial change and discusses the problem of using location as an argument for not being able to lure blacks into university publishing. Howard University Press is used to illustrate the problem of budget cutting and the ability to boost black recruitment efforts or establish a united black press…

  6. The Pedagogical Press: Problems and Trends.

    ERIC Educational Resources Information Center

    Soviet Education, 1990

    1990-01-01

    Presents a discussion by journalists, scientists, and writers on educational problems in the Soviet Union. Focuses on the the role of the pedagogical press in restructuring public education in light of perestroika. Calls for press involvement in defining and developing public education. Lists questions for consideration and invites responses. (NL)

  7. Fracture toughness of hot-pressed beryllium

    NASA Technical Reports Server (NTRS)

    Lemon, D. D.; Brown, W. F., Jr.

    1985-01-01

    This paper presents the results of an investigation into the fracture toughness, sustained-load flaw growth, and fatigue-crack propagation resistance of S200E hot-pressed beryllium at room temperature. It also reviews the literature pertaining to the influence of various factors on the fracture toughness of hot-pressed beryllium determined using fatigue-cracked specimens.

  8. Teenagers as Victims in the Press

    ERIC Educational Resources Information Center

    Andersson, Gunvor; Lundstrom, Tommy

    2007-01-01

    Research into press reporting on young people has tended to concentrate on young people as offenders. In contrast, this article focuses on press coverage of teenagers as victims. Reports in two Swedish newspapers (a morning broadsheet and an evening tabloid) were studied over a period of four months and subjected to a qualitative analysis of…

  9. 28 CFR 540.64 - Press pools.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Press pools. 540.64 Section 540.64... PERSONS IN THE COMMUNITY Contact With News Media § 540.64 Press pools. (a) The Warden may establish a... shall notify all news media representatives who have requested interviews or visits that have not...

  10. 28 CFR 540.64 - Press pools.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Press pools. 540.64 Section 540.64... PERSONS IN THE COMMUNITY Contact With News Media § 540.64 Press pools. (a) The Warden may establish a... shall notify all news media representatives who have requested interviews or visits that have not...

  11. 28 CFR 540.64 - Press pools.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Press pools. 540.64 Section 540.64... PERSONS IN THE COMMUNITY Contact With News Media § 540.64 Press pools. (a) The Warden may establish a... shall notify all news media representatives who have requested interviews or visits that have not...

  12. 28 CFR 540.64 - Press pools.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Press pools. 540.64 Section 540.64... PERSONS IN THE COMMUNITY Contact With News Media § 540.64 Press pools. (a) The Warden may establish a... shall notify all news media representatives who have requested interviews or visits that have not...

  13. 28 CFR 540.64 - Press pools.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Press pools. 540.64 Section 540.64... PERSONS IN THE COMMUNITY Contact With News Media § 540.64 Press pools. (a) The Warden may establish a... shall notify all news media representatives who have requested interviews or visits that have not...

  14. Special Section: University Presses and Libraries.

    ERIC Educational Resources Information Center

    Berry, John; And Others

    1986-01-01

    Describes issues discussed at the Association of American University Presses, June 1986 meeting, as being divided between those interested in using the techniques of commercial publishers and those committed to publishing what is worthy. Chandler Grannis describes "New Directions for University Presses" and Doug Armato "The Power of 'Serious'…

  15. A comparison of impulse drying to double felted pressing on pilot- scale shoe presses and roll presses. Progress report, No. 6

    SciTech Connect

    Orloff, D.I.

    1992-08-01

    Pilot-scale shoe press and roll press experiments have been conducted to compare impulse drying and double felted pressing. Both ceramic coated and Beloit Type C press rolls have been evaluated. The experiments show that impulse drying can provide significantly higher outgoing solids than double felled pressing at the same impulse. For example, at an impulse of 0.234 MPa seconds (34 psi seconds), sheets at an ingoing solids of 52% were impulse dried (using the Beloit Type C press roll) to 68% solids while optimized double felled pressing could only yield press dryness of, at most, 60%.

  16. STS-99 Prelaunch Press Briefing

    NASA Technical Reports Server (NTRS)

    2000-01-01

    The primary objective of the STS-99 mission was to complete high resolution mapping of large sections of the Earth's surface using the Shuttle Radar Topography Mission (SRTM), a specially modified radar system. This radar system produced unrivaled 3-D images of the Earth's Surface. The mission was launched at 12:31 on February 11, 2000 onboard the space shuttle Endeavour, and led by Commander Kevin Kregel. The crew was Pilot Dominic L. Pudwill Gorie and Mission Specialists Janet L. Kavandi, Janice E. Voss, Mamoru Mohri from the National Space Development Agency (Japanese Space Agency), and Gerhard P. J. Thiele from DARA (German Space Agency). This videotape shows a press briefing about a mechanical problem that the shuttle was having. There was discussion about possibly scrubbing the launch due to the problem with the Enhanced Master Events Controller. A problem with a fuel pump part had also become evident and there was discussion about the impact that this could have on the flight.

  17. Mariner Mars 1971: Press kit

    NASA Technical Reports Server (NTRS)

    Mittauer, R. T.

    1971-01-01

    The news release describes the 1971 launches of Mariner 8 and 9 which were to be the first attempt by NASA to orbit another planet, Mars. Described are: (1) mission capsule; (2) planetary missions; (3) aiming zones; (4) the spacecraft; (5) scientific experiments to be performed; (6) Atlas Centaur launch vehicle; (7) launch operations; (8) tracking and data system and mission operations; and (9) Mariner Mars 71 team and subcontractors.

  18. Development of the AP Technology Through Time

    NASA Astrophysics Data System (ADS)

    Charmier, F.; Martin, O.; Gariepy, R.

    2015-02-01

    This article presents the historical development of the AP Technology (Aluval, Voreppe, France) pot series starting with the AP13 in the 1960s, followed by the AP18 and the AP30 in the 1980s and 1990s. For most of the modern-era technology, from the late 1970s on, development has been based on a three-stage pattern, the first one being the pot modeling, followed by the pot prototype stage, and then the industrial stage, which fully validated the technology. This development pattern has proven to be successful since it has led to the very robust AP Technology pot design generation and a large number of greenfield smelters built in the 1990-2010 selected the AP Technology design. AP60 is the latest of this series: The development at the prototype level was initiated in the 1990s and is presented in the article. It is now followed by the first industrial realization at Jonquière with the startup in late 2013 and the full validation of the technology in mid-2014. The development of APXe, which aims at very low energy consumption, uses many common elements pertaining to the AP60 design and is presented in the article. AP Technology has also addressed the need for continuous and fast improvement of pot performances adapted to each existing client or site specifics; for this purpose, a new development methodology has recently emerged thanks to the very high modeling capabilities. This methodology, based on the validation of "technology bricks" and their integration in the final design following a strict process, is presented in the last section of this article.

  19. Number of Schools Offering AP Falls after First Audit of Courses

    ERIC Educational Resources Information Center

    Cech, Scott J.

    2007-01-01

    This article reports the findings of the first audit of Advanced Placement (AP) courses. One of the more striking effects of the audit, the results of which were released recently by the College Board, was a steep drop in the number of schools offering Advanced Placement courses. After more than 30 years of steady growth, the number of schools…

  20. Operation of the APS rf gun.

    SciTech Connect

    Lewellen, J. W.

    1998-09-11

    The Advanced Photon Source (APS) has a thermionic-cathode rf gun system capable of providing beam to the APS linac. The gun system consists of a 1.6-cell thermionic-cathode rf gun, a fast kicker for beam current control, and an alpha magnet for bunch compression and injection into the APS linac line. This system is intended for use both as an injector for positron creation, and as a first beam source for the Low-Energy Undulator Test Line (LEUTL) project [1]. The first measured performance characteristics of the gun are presented.

  1. Tank 241-AP-107, grab samples, 7AP-99-1, 7AP-99-3 and 7AP-99-4 analytical results for the final report

    SciTech Connect

    BELL, K.E.

    1999-08-12

    This document is the format IV, final report for the tank 241-AP-107 (AP-107) grab samples taken in May 1999 to address waste compatibility concerns. Chemical, radiochemical, and physical analyses on the tank AP-107 samples were performed as directed in Compatibility Grab Sampling and Analysis Plan for Fiscal year 1999. Any deviations from the instructions provided in the tank sampling and analysis plan (TSAP) were discussed in this narrative. Interim data were provided earlier to River Protection Project (RPP) personnel, however, the data presented here represent the official results. No notification limits were exceeded.

  2. APS Activities with Other Professional Societies

    NASA Astrophysics Data System (ADS)

    Slakey, Francis

    2006-03-01

    In 1981, the APS Council issued a statement that opposed ``equal time'' presentation in public school science classes of creationism and evolution. The statement clarified that ``Scientific inquiry and religious beliefs are two distinct elements of the human experience. Attempts to present them in the same context can only lead to misunderstandings of both.'' The APS Council revisited the issue in 1999 when a school board in Kansas attempted to eliminate the Big Bang, among other issues, from the science curriculum. Since that time, the APS has been more directly involved in confronting efforts that would dilute the teaching of science in public school science classes. This talk will review the APS activities and describe a developing multi-science society activity.

  3. Meet the APS Editors Coffee Break

    NASA Astrophysics Data System (ADS)

    2014-03-01

    The APS Journal Editors invite you to join them for conversation and light refreshments. The Editors will be available to answer questions, discuss your ideas, and listen to your comments about the journals. All are welcome to attend.

  4. Role of AP1 and Gadkin in the traffic of secretory endo-lysosomes

    PubMed Central

    Laulagnier, Karine; Schieber, Nicole L.; Maritzen, Tanja; Haucke, Volker; Parton, Robert G.; Gruenberg, Jean

    2011-01-01

    Whereas lysosome-related organelles (LRO) of specialized cells display both exocytic and endocytic features, lysosomes in nonspecialized cells can also acquire the property to fuse with the plasma membrane upon an acute rise in cytosolic calcium. Here, we characterize this unconventional secretory pathway in fibroblast-like cells, by monitoring the appearance of Lamp1 on the plasma membrane and the release of lysosomal enzymes into the medium. After sequential ablation of endocytic compartments in living cells, we find that donor membranes primarily derive from a late compartment, but that an early compartment is also involved. Strikingly, this endo-secretory process is not affected by treatments that inhibit endosome dynamics (microtubule depolymerization, cholesterol accumulation, overexpression of Rab7 or its effector Rab-interacting lysosomal protein [RILP], overexpression of Rab5 mutants), but depends on Rab27a, a GTPase involved in LRO secretion, and is controlled by F-actin. Moreover, we find that this unconventional endo-secretory pathway requires the adaptor protein complexes AP1, Gadkin (which recruits AP1 by binding to the ?1 subunit), and AP2, but not AP3. We conclude that a specific fraction of the AP2-derived endocytic pathway is dedicated to secretory purposes under the control of AP1 and Gadkin. PMID:21525240

  5. Apollo 13 Facts [Post Flight Press Conference

    NASA Technical Reports Server (NTRS)

    2001-01-01

    The Apollo 13 astronauts, James Lovell, Jr., John Swigert, Jr., and Fred Haise, Jr., are seen during this post flight press conference. They describe their mission and answer questions from the audience.

  6. Regulation of atriopeptin release from the isolated rat heart

    SciTech Connect

    Currie, M.G.; Newman, W.H.

    1986-03-05

    Recent studies have demonstrated that the mammalian atria possess an endocrine function which appears to play a role in the regulation of systemic arterial pressure, fluid balance, and electrolyte homeostasis. They have begun to study the regulation of atriopeptin (atrial natriuretic factor) release into the coronary effluent of the isolated perfused rat heart. Characterization by high pressure liquid chromatography of the form of the hormone released indicates that the predominant form is the active low MW circulating hormone not the pro-hormone. The release of immunoreactive atriopeptin (iAP) was stimulated by infusion of norepinephrine (1 ..mu..M) or epinephrine (1 ..mu..M) 3.0 and 2.6-fold, respectively. The ..beta..-adrenergic agonist isoproterenol and the ..cap alpha..-2 adrenergic agonist BHT-920 lacked effects on iAP release. On the other hand, the ..cap alpha..-1 adrenergic agonist phenylephrine caused a dose-dependent increase in release of iAP. Release of iAP stimulated by phenylephrine was inhibited by the ..cap alpha.. antagonist phentolamine. Further, iAP release was stimulated 4.2-fold by phorbol ester (1 ..mu..M) but was not affected by 4-..beta.. phorbol (1 ..mu..M). From these collective data they conclude that the release of atriopeptin is stimulated by ..cap alpha..-1 receptor activation and that protein kinase C participates in the regulation of secretion. The data suggests that the sympathetic nervous system may play a physiologic role in the regulation of atriopeptin secretion.

  7. Automated Plasma Spray (APS) process feasibility study

    NASA Technical Reports Server (NTRS)

    Fetheroff, C. W.; Derkacs, T.; Matay, I. M.

    1981-01-01

    An automated plasma spray (APS) process was developed to apply two layer (NiCrAlY and ZrO2-12Y2O3) thermal barrier coatings to aircraft and stationary gas turbine engine blade airfoils. The APS process hardware consists of four subsystems: a mechanical positioning subsystem incorporating two interlaced six degree of freedom assemblies (one for coating deposition and one for coating thickness monitoring); a noncoherent optical metrology subsystem (for in process gaging of the coating thickness buildup at specified points on the specimen); a microprocessor based adaptive system controller (to achieve the desired overall thickness profile on the specimen); and commerical plasma spray equipment. Over fifty JT9D first stage aircraft turbine blade specimens, ten W501B utility turbine blade specimens and dozens of cylindrical specimens were coated with the APS process in preliminary checkout and evaluation studies. The best of the preliminary turbine blade specimens achieved an overall coating thickness uniformity of 53 micrometers (2.1 mils), much better than is achievable manually. Comparative evaluations of coating thickness uniformity for manually sprayed and APS coated specimens were performed. One of the preliminary turbine blade evaluation specimens was subjected to a torch test and metallographic evaluation. Some cylindrical specimens coated with the APS process survived up to 2000 cycles in subsequent burner rig testing.

  8. Simplified SBLOCA Analysis of AP1000

    SciTech Connect

    Brown, William L.

    2004-07-01

    The AP1000 is a 1000 MWe advanced nuclear power plant design that uses passive safety features such as a multi-stage, automatic depressurization system (ADS) and gravity-driven, safety injection from core make-up tanks (CMTs) and an in-containment refueling water storage tank (IRWST) to mitigate SBLOCA events. The period of most safety significance for AP1000 during a SBLOCA event is typically associated with the actuation of the fourth stage of the ADS and subsequent transition from CMT to IRWST safety injection. As this period of a SBLOCA is generally of a quasi-steady nature, the integral performance of the AP1000 can be understood and evaluated with a simplified model of the reactor vessel, ADS, and safety injection from the CMTs and IRWST. The simplified model of the AP1000 consists of a series of steady state simulations that uses drift flux in the core region and homogeneous treatment of the core exit region including the ADS flow paths to generate a family of core flow demand curves as a function of system pressure (i.e. mass flow required to satisfy core cooling). These core flow demand curves are plotted against passive safety system supply curves from the CMTs and IRWST to demonstrate the adequacy of the integral performance of the AP1000 during the most important phase of a SBLOCA. (author)

  9. Tank 241-AP-107, grab samples 7AP-97-1, 7AP-97-2 and 7AP-97-3 analytical results for the final report

    SciTech Connect

    Steen, F.H.

    1997-12-22

    This document is the final report for tank 241-AP-107 grab samples. Three grab samples were collected from riser 1 on September 11, 1997. Analyses were performed on samples 7AP-97-1, 7AP-97-2 and 7AP-97-3 in accordance with the Compatibility Grab Sampling and Analysis Plan (TSAP) (Sasaki, 1997) and the Data Quality Objectives for Tank Farms Waste Compatibility Program (DQO) (Rev. 1: Fowler, 1995; Rev. 2: Mulkey and Nuier, 1997). The analytical results are presented in the data summary report (Table 1). A notification was made to East Tank Farms Operations concerning low hydroxide in the tank and a hydroxide (caustic) demand analysis was requested. The request for sample analysis (RSA) (Attachment 2) received for AP-107 indicated that the samples were polychlorinated biphenyl (PCB) suspects. Therefore, prior to performing the requested analyses, aliquots were made to perform PCB analysis in accordance with the 222-S Laboratory administrative procedure, LAP-101-100. The results of this analysis indicated that no PCBs were present at 50 ppm and analysis proceeded as non-PCB samples. The results and raw data for the PCB analysis will be included in a revision to this document. The sample breakdown diagrams (Attachment 1) are provided as a cross-reference for relating the tank farm customer identification numbers with the 222-S Laboratory sample numbers and the portion of sample analyzed.

  10. Application of CMOS APS in star tracker

    NASA Astrophysics Data System (ADS)

    Liu, Zhi; Wang, Yefan; Yang, Jingyi; Hao, Zhihang

    2002-09-01

    Small satellites are now capable of performing missions that require accurate attitude determination and control. However, low weight, size, power, and cost requirements limit the types of attitude sensors that can be used on a small craft, making attitude estimation difficult. In particular, star trackers -- often the attitude sensors of choice for spacecraft, ballistic missile etc., are not practical for small satellites, and CMOS APS is a good substitute for attitude sensors. Some of the technical advantages of CMOS APS are no blooming, low power consumption, direct digital output, small size and little support circuitry, simple to design, etc. This paper discusses the application probability of CMOS APS technology in star tracker for use in small satellites. A ground-based prototype vision system based on CMOS APS has been built to demonstrate the advantages of using CMOS APS in star tracker. Resolving capability, noise, radiation hardening and some other characteristics are discussed in detail. CMOS image sensor is sure to be a potential replacement of CCD in the field of attitude sensors.

  11. Building an AP Social Studies Program with Non-Traditional AP Students

    ERIC Educational Resources Information Center

    Ashmead, Amanda; Blanchette, Sue

    2013-01-01

    Equal access to education, that is to a high quality education, has increasingly come to mean access to an Advanced Placement program. In recent years, there has been steady attention paid to opening access to AP programs. The 9th annual College Board report (2013) stated "students who succeed on an AP Exam during high school typically…

  12. Ectopic expression of FaesAP3, a Fagopyrum esculentum (Polygonaceae) AP3 orthologous gene rescues stamen development in an Arabidopsis ap3 mutant.

    PubMed

    Fang, Zheng-wu; Qi, Rui; Li, Xiao-fang; Liu, Zhi-xiong

    2014-10-25

    Arabidopsis thaliana APETALA3 (AP3) and Antirrhinum majus DEFICIENS (DEF) MADS box genes are required to specify petal and stamen identity. AP3 and DEF are members of the euAP3 lineage, which arose by gene duplication coincident with radiation of the core eudicots. In order to investigate the molecular mechanisms underlying organ development in early diverging clades of core eudicots, we isolated and identified an AP3 homolog, FaesAP3, from Fagopyrum esculentum (buckwheat, Polygonaceae), a multi-food-use pseudocereal with healing benefits. Protein sequence alignment and phylogenetic analyses revealed that FaesAP3 grouped into the euAP3 lineage. Expression analysis showed that FaesAP3 was transcribed only in developing stamens, and differed from AP3 and DEF, which expressed in developing petals and stamens. Moreover, ectopic expression of FaesAP3 rescued stamen development without complementation of petal development in an Arabidopsis ap3 mutant. Our results suggest that FaesAP3 is involved in the development of stamens in buckwheat. These results also suggest that FaesAP3 holds some potential for biotechnical engineering to create a male sterile line of F. esculentum. PMID:25149019

  13. Plyler Prize and APS Fellow Introductions

    NASA Astrophysics Data System (ADS)

    Nathanson, Gilbert

    2014-03-01

    The Division of Chemical Physics is delighted to announce the 2013 APS Fellows sponsored by DCP and to honor the 2014 Earl K. Plyler Prize Award winner. The new APS Fellows are: Ilan Benjamin, Hua Guo, Manos Mavrikakis, Josef Paldus, Joern Siepmann, Hans-Peter Steinrueck, Douglas Tobias, Angela Wilson, and Yijing Yan. The citations for each awardee will be read out loud. I will also introduce Prof. Lai-Sheng Wang of the Department of Chemistry at Brown University, who was awarded the 2014 Plyler Prize for Molecular Spectroscopy and Dynamics. Please come learn about these extraordinary scientists during this prize session. Prof. Wang's Plyler Prize talk will follow immediately after this introduction. For more information, see http://www.aps.org/units/dcp/.

  14. On the periodic variations of geomagnetic activity indices Ap and ap

    NASA Astrophysics Data System (ADS)

    Schreiber, H.

    1998-05-01

    Yearly averages of geomagnetic activity indices Ap for the years 1967-1984 are compared to the respective averages of 2·Bs, where v is the solar wind velocity and Bs is the southward interplanetary magnetic field (IMF) component. The correlation of both quantities is known to be rather good. Comparing the averages of Ap with 2 and Bs separately we find that, during the declining phase of the solar cycle, 2 and during the ascending phase Bs have more influence on Ap. According to this observation (using Fourier spectral analysis) the semiannual and 27 days, Ap variations for the years 1932-1993 were analysed separately for years before and after sunspot minima. Only those time-intervals before sunspot minima with a significant 27-day recurrent period of the IMF sector structure and those intervals after sunspot minima with a significant 28-28.5-day recurrent period of the sector structure were used. The averaged spectra of the two Ap data sets clearly show a period of 27 days before and a period of 28-29 days after sunspot minimum. Moreover, the phase of the average semiannual wave of Ap is significantly different for the two groups of data: the Ap variation maximizes near the equinoxes during the declining phase of the sunspot cycle and near the beginning of April and October during the ascending phase of the sunspot cycle, as predicted by the Russell-McPherron (R-M) mechanism. Analysing the daily variation of ap in an analogue manner, the same equinoctial and R-M mechanisms are seen, suggesting that during phases of the solar cycle, when ap depends more on the IMF-Bs component, the R-M mechanism is predominant, whereas during phases when ap increases as v increases the equinoctial mechanism is more likely to be effective.

  15. Textbook Sales Drop, and University Presses Search for Reasons

    ERIC Educational Resources Information Center

    Howard, Jennifer

    2008-01-01

    This article reports that textbook sales are falling at many university presses, a trend that has accelerated in the past couple of months. That's the word from press directors anxious about the decline but unsure what's causing it or how to stop it. Not every press has been affected. Two of the biggest players, Oxford University Press and…

  16. Graphic Arts: Book Three. The Press and Related Processes.

    ERIC Educational Resources Information Center

    Farajollahi, Karim; And Others

    The third of a three-volume set of instructional materials for a graphic arts course, this manual consists of nine instructional units dealing with presses and related processes. Covered in the units are basic press fundamentals, offset press systems, offset press operating procedures, offset inks and dampening chemistry, preventive maintenance

  17. AUPress: A Comparison of an Open Access University Press with Traditional Presses

    ERIC Educational Resources Information Center

    McGreal, Rory; Chen, Nian-Shing

    2011-01-01

    This study is a comparison of AUPress with three other traditional (non-open access) Canadian university presses. The analysis is based on the rankings that are correlated with book sales on Amazon.com and Amazon.ca. Statistical methods include the sampling of the sales ranking of randomly selected books from each press. The results of one-way…

  18. DISPLAY OF AMMUNITION PRODUCED ON #8 PRESS (U.S. GOVERNMENT PRESS), ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    DISPLAY OF AMMUNITION PRODUCED ON #8 PRESS (U.S. GOVERNMENT PRESS), SHOWING THE STAGES THROUGH WHICH THE PRODUCTS ARE DRAWN AND FORMED, BEGINNING WITH THE CUPS ON THE LEFT SIDE OF EACH ROW. - American Brass Foundry, 70 Sayre Street, Buffalo, Erie County, NY

  19. Whoopers Released

    A Whooping crane chick is released into a temporary pen to acclimate before being released into the wild.  Four of the endangered chicks, hatched and raised by their parents at the U.S. Geological Survey’s Patuxent Wildlife Research Center in Laurel, Maryland, were released on Necedah Nat...

  20. Influence of Volume Deformation Rate on the Intensity of Oil-Bearing Crop Pressing-out in Relation to Rape Extrudate

    NASA Astrophysics Data System (ADS)

    Slavnov, E. V.; Petrov, I. A.

    2015-07-01

    The influence of the volume deformation rate on the intensity of piston pressing-out of oil has been investigated. The results of pressing by a piston moving with different speeds are presented. Mathematical simulation is carried out for the stage of pressing-out after the termination of sample loading, when oil release occurs due to the accumulated deformations of the skeleton. It has been assumed that in mechanical pressing there remains the least residual content of oil. A dimensionless complex representing the ratio of the characteristic times of loading to the material response (the process of pressing) has been obtained. The dependence of the rate of oil pressing-out at the stage of pressure relaxation on the dimensionless complex has been determined.

  1. Implementing Strategies for Drying and Pressing Wood Without Emissions Controls

    SciTech Connect

    Sujit Banerjee; Terrance Conners

    2007-09-07

    Drying and pressing wood for the manufacture of lumber, particleboard, oriented strand board (OSB), veneer and medium density fiberboard (MDF) release volatile organic compounds (VOCs) into the atmosphere. These emissions require control equipment that are capital-intensive and consume significant quantities of natural gas and electricity. The objective of our work was to understand the mechanisms through which volatile organic compounds are generated and released and to develop simple control strategies. Of the several strategies developed, two have been implemented for OSB manufacture over the course of this study. First, it was found that increasing final wood moisture by about 2-4 percentage points reduced the dryer emissions of hazardous air pollutants by over 70%. As wood dries, the escaping water evaporatively cools the wood. This cooling tapers off wood when the wood is nearly dry and the wood temperature rises. Thermal breakdown of the wood tissue occurs and VOCs are released. Raising the final wood moisture by only a few percentage points minimizes the temperature rise and reduces emissions. Evaporative cooling also impacts has implications for VOC release from wood fines. Flaking wood for OSB manufacture inevitable generates fines. Fines dry out rapidly because of their high surface area and evaporative cooling is lost more rapidly than for flakes. As a result, fines emit a disproportionate quantity of VOCs. Fines can be reduced in two ways: through screening of the green furnish and through reducing their generation during flaking. The second approach is preferable because it also increased wood yield. A procedure to do this by matching the sharpness angle of the flaker knife to the ambient temperature was also developed. Other findings of practical interests are as follows: Dielectric heating of wood under low-headspace conditions removes terpenes and other extractives from softwood; The monoterpene content in trees depend upon temperature and seasonal effects; Method 25A emissions from lumber drying can be modeled from a knowledge of the airflow through the kiln; A heat transfer model shows that VOCs released during hot-pressing mainly originate from the surface of the board; and Boiler ash can be used to adsorb formaldehyde from air streams.

  2. EPICS release 3.11 specific documentation -- EPICS release notes for 3.11

    SciTech Connect

    1994-01-19

    EPICS release 3.11 is now ready for user testing. A person who wants to set up a simplified application environment to boot an IOC and create databases using R3.11 should follow the directions in Appendix B, page 27, of the EPICS Source/Release Control Manual, Sept. 20, 1993. The R3.11 EPICS path at ANL/APS is /net/phebos/epics/R3.11 so the command to get the new release is /net/phebos/epics/R3.11/Unix/share/bin/getrel /net/phebos/epics/R3.11. An existing R3.8 short form report can be copied to this new directory and used to create a database. ANL/APS is currently testing an Application Developers Source/Release control system. It is not yet ready for general distribution. Attached are the EPICS R3.11 release notes.

  3. The Dao of human cloning: utopian/dystopian hype in the British press and popular films.

    PubMed

    Jensen, Eric

    2008-04-01

    The issue of human cloning has featured in the national science policy agendas in both the United States and the United Kingdom since the announcement in 1997 of Dolly the cloned sheep's birth in Scotland. Such news stories suggesting the imminent cloning of humans have inspired fictional entertainment media over the years, including numerous popular films. Study 1 examines elite British press coverage of human cloning from 1997 to 2004 (n = 857). Study 2 focuses on five human cloning films released between 1978 and 2003. Two sharply divergent discourses emerged from these data. Unqualified hope and habitually hyped claims of future cures permeated the press discourse. In contrast, the films constructed human cloning as an inherently dangerous technology often wielded by hubristic scientists in the tradition of Frankenstein. Both the predominately positive hype in the broadsheet press and the largely negative hype in the films indicate an impoverished and "thin" public debate on the issue of human cloning. PMID:19391375

  4. Aerial view of the Press Site

    NASA Technical Reports Server (NTRS)

    1998-01-01

    In this aerial view, The News Center sits beyond a large parking lot, on a hill at the northeastern end of the Launch Complex 39 Area , next to the turn basin (at left). From left, the grandstand faces the launch pads several miles away on the Atlantic seashore; behind it, the television studio is the site of media conferences; next, the large white-roofed building is the hub of information and activity for press representatives. Lined up on the right of the Press Site are various buildings and trailers, home to major news networks. The parking lot can accommodate the hundreds of media personnel who attend Space Shuttle launches.

  5. Expanded Analysis of Hot Isostatic Pressed Iodine-Loaded Silver-Exchanged Mordenite

    SciTech Connect

    Jubin, R. T.; Bruffey, S. H.; Patton, K. K.

    2014-09-30

    Reduced silver-exchanged mordenite (Ag0Z) is being evaluated as a potential material to control the release of radioactive iodine that is released during the reprocessing of used nuclear fuel into the plant off-gas streams. The purpose of this study was to determine if hot pressing could directly convert this iodine loaded sorbent into a waste form suitable for long-term disposition. The minimal pretreatment required for production of pressed pellets makes hot pressing a technically and economically desirable process. Initial scoping studies utilized hot uniaxial pressing (HUPing) to prepare samples of non-iodine-loaded reduced silver exchanged mordenite (Ag0Z). The resulting samples were very fragile due to the low pressure (~ 28 MPa) used. It was recommended that hot isostatic pressing (HIPing), performed at higher temperatures and pressures, be investigated. HIPing was carried out in two phases, with a third and final phase currently underway. Phase I evaluated the effects of pressure and temperature conditions on the manufacture of a pressed sample. The base material was an engineered form of silver zeolite. Six samples of Ag0Z and two samples of I-Ag0Z were pressed. It was found that HIPing produced a pressed pellet of high density. Analysis of each pressed pellet by scanning electron microscopy-energy dispersive spectrophotometry (SEM-EDS) and X-ray diffraction (XRD) demonstrated that under the conditions used for pressing, the majority of the material transforms into an amorphous structure. The only crystalline phase observed in the pressed Ag0Z material was SiO2. For the samples loaded with iodine (I-Ag0Z) iodine was present as AgI clusters at low temperatures, and transformed into AgIO4 at high temperatures. Surface mapping and EDS demonstrate segregation between silver iodide phases and silicon dioxide phases. Based on the results of the Phase I study, an expanded test matrix was developed to examine the effects of multiple source materials, compositional variations, and an expanded temperature range. Each sample was analyzed with the approach used in Phase I. In all cases, there is nothing in the SEM or XRD analyses that indicates creation of any AgI-containing silicon phase, with the samples being found to be largely amorphous. Phase III of this study has been initiated and is the final phase of scoping tests. It will expand upon the test matrix completed in Phase II and will examine the durability of the pressed pellets through product consistency testing (PCT) studies. Transformation of the component material into a well-characterized iodine-containing mineral phase would be desirable. This would limit the additional experimental testing and modeling required to determine the long-term stability of the pressed pellet, as much of that information has already been learned for several common iodine-containing minerals. However, this is not an absolute requirement, especially if pellets produced by hot isostatic pressing can be demonstrated through initial PCT studies to retain iodine well despite their amorphous composition.

  6. The AP Descriptive Chemistry Question: Student Errors

    ERIC Educational Resources Information Center

    Crippen, Kent; Brooks, David W.

    2005-01-01

    For over a decade, the authors have been involved in a design theory experiment providing software for high school students preparing for the descriptive question on the Advanced Placement (AP) chemistry examination. Since 1997, the software has been available as a Web site offering repeatable practice. This study describes a 4-year project during

  7. Boosting Black Academic Achievement and AP Enrollments

    ERIC Educational Resources Information Center

    Saunders, Terrie; Maloney, Kathy

    2005-01-01

    Minority students were about 25% of the student population at Central High School in Omaha, Nebraska, in 1995. But the composition of its honors and challenge classes did not reflect this diversity: Few minority students were taking challenge classes as underclassmen and even fewer were taking Advanced Placement (AP) courses as seniors. This paper…

  8. Teaching Journalistic Style with the "AP Stylebook."

    ERIC Educational Resources Information Center

    DiNicola, Robert

    1994-01-01

    Argues for exposing journalism students to a standard stylebook like the "AP Stylebook." Notes that, besides covering aspects of style, the stylebook is a source of useful information and may stimulate worthwhile discussion as it addresses issues of "political correctness." (SR)

  9. Lysosomal Targeting of Cystinosin Requires AP-3.

    PubMed

    Andrzejewska, Zuzanna; Névo, Nathalie; Thomas, Lucie; Bailleux, Anne; Chauvet, Véronique; Benmerah, Alexandre; Antignac, Corinne

    2015-07-01

    Cystinosin is a lysosomal cystine transporter defective in cystinosis, an autosomal recessive lysosomal storage disorder. It is composed of seven transmembrane (TM) domains and contains two lysosomal targeting motifs: a tyrosine-based signal (GYDQL) in its C-terminal tail and a non-classical motif in its fifth inter-TM loop. Using the yeast two-hybrid system, we showed that the GYDQL motif specifically interacted with the μ subunit of the adaptor protein complex 3 (AP-3). Moreover, cell surface biotinylation and total internal reflection fluorescence microscopy revealed that cystinosin was partially mislocalized to the plasma membrane (PM) in AP-3-depleted cells. We generated a chimeric CD63 protein to specifically analyze the function of the GYDQL motif. This chimeric protein was targeted to lysosomes in a manner similar to cystinosin and was partially mislocalized to the PM in AP-3 knockdown cells where it also accumulated in the trans-Golgi network and early endosomes. Together with the fact that the surface levels of cystinosin and of the CD63-GYDQL chimeric protein were not increased when clathrin-mediated endocytosis was impaired, our data show that the tyrosine-based motif of cystinosin is a 'strong' AP-3 interacting motif responsible for lysosomal targeting of cystinosin by a direct intracellular pathway. PMID:25753619

  10. The Demographic Wave: Rethinking Hispanic AP Trends

    ERIC Educational Resources Information Center

    Edwards, Kelcey; Sawtell, Ellen

    2013-01-01

    Presented at the Advanced Placement Annual Conference (APAC) in Las Vegas, NV in July 2013. This presentation reviews new research examining the AP® experience of Hispanic graduates over the past decade. Topics include an in-depth look at the AP Spanish Language and Culture gateway hypothesis and trends in family characteristics such as parent…

  11. Structuring the AP Art History Course

    ERIC Educational Resources Information Center

    Herscher, Walter R.

    2013-01-01

    While AP (Advanced Placement) Art History may be taught within the art department in many schools, social studies teachers are equally capable of teaching the course well. They have the historical background to discuss the reasons for changes in art styles. A teacher's preparation is similar to teaching a course stressing political history,…

  12. APS deposition facility upgrades and future plans

    NASA Astrophysics Data System (ADS)

    Conley, Ray; Shi, Bing; Erdmann, Mark; Izzo, Scott; Assoufid, Lahsen; Goetze, Kurt; Mooney, Tim; Lauer, Kenneth

    2014-09-01

    The Advanced Photon Source (APS) has recently invested resources to upgrade or replace aging deposition systems with modern equipment. Of the three existing deposition systems, one will receive an upgrade, while two are being replaced. A design which adds a three-substrate planetary for the APS rotary deposition system is almost complete. The replacement for the APS large deposition system, dubbed the "Modular Deposition System", has been conceptually designed and is in the procurement process. Eight cathodes will sputter horizontally on mirrors up to 1.5 meters in length. This new instrument is designed to interface with ion-milling instruments and various metrology equipment for ion-beam figuring. A third linear machine, called the APS Profile Coating System, has two cathodes and is designed to accept substrates up to 200mm in length. While this machine is primarily intended for fabrication of figured KB mirrors using the profile-coating technique, it has also been used to produce multilayer monochromators for beamline use.

  13. The Promise of AP World History

    ERIC Educational Resources Information Center

    Saldaña, Cristóbal T.

    2013-01-01

    AP World History is the ideal history course. It introduces students to 10,000 years of world history, and demands critical reading, critical writing, and critical thinking skills on the part of both the teacher and the students. It requires students to build their expertise in reading their textbook, and places demands on the teacher to assign…

  14. The AP Descriptive Chemistry Question: Student Errors

    ERIC Educational Resources Information Center

    Crippen, Kent; Brooks, David W.

    2005-01-01

    For over a decade, the authors have been involved in a design theory experiment providing software for high school students preparing for the descriptive question on the Advanced Placement (AP) chemistry examination. Since 1997, the software has been available as a Web site offering repeatable practice. This study describes a 4-year project during…

  15. Two Successful Approaches to Teaching AP Government

    ERIC Educational Resources Information Center

    Ladd, Brian; Stepp, Heidi

    2013-01-01

    Amador Valley High School, in Pleasanton, California, uses two unique approaches to teaching Advanced Placement Government and Politics. AP Government consists of six units: Constitutional Underpinnings; Political Behavior and Political Beliefs; Mass Media, Interest Groups, and Political Parties; Institutions of Government; Civil Liberties and…

  16. The Promise of AP World History

    ERIC Educational Resources Information Center

    Saldaa, Cristbal T.

    2013-01-01

    AP World History is the ideal history course. It introduces students to 10,000 years of world history, and demands critical reading, critical writing, and critical thinking skills on the part of both the teacher and the students. It requires students to build their expertise in reading their textbook, and places demands on the teacher to assign

  17. Two Successful Approaches to Teaching AP Government

    ERIC Educational Resources Information Center

    Ladd, Brian; Stepp, Heidi

    2013-01-01

    Amador Valley High School, in Pleasanton, California, uses two unique approaches to teaching Advanced Placement Government and Politics. AP Government consists of six units: Constitutional Underpinnings; Political Behavior and Political Beliefs; Mass Media, Interest Groups, and Political Parties; Institutions of Government; Civil Liberties and

  18. The clathrin adaptor AP-1A mediates basolateral polarity.

    PubMed

    Gravotta, Diego; Carvajal-Gonzalez, Jose Maria; Mattera, Rafael; Deborde, Sylvie; Banfelder, Jason R; Bonifacino, Juan S; Rodriguez-Boulan, Enrique

    2012-04-17

    Clathrin and the epithelial-specific clathrin adaptor AP-1B mediate basolateral trafficking in epithelia. However, several epithelia lack AP-1B, and mice knocked out for AP-1B are viable, suggesting the existence of additional mechanisms that control basolateral polarity. Here, we demonstrate a distinct role of the ubiquitous clathrin adaptor AP-1A in basolateral protein sorting. Knockdown of AP-1A causes missorting of basolateral proteins in MDCK cells, but only after knockdown of AP-1B, suggesting that AP-1B can compensate for lack of AP-1A. AP-1A localizes predominantly to the TGN, and its knockdown promotes spillover of basolateral proteins into common recycling endosomes, the site of function of AP-1B, suggesting complementary roles of both adaptors in basolateral sorting. Yeast two-hybrid assays detect interactions between the basolateral signal of transferrin receptor and the medium subunits of both AP-1A and AP-1B. The basolateral sorting function of AP-1A reported here establishes AP-1 as a major regulator of epithelial polarity. PMID:22516199

  19. The Clathrin Adaptor AP-1A Mediates Basolateral Polarity

    PubMed Central

    Gravotta, Diego; Carvajal-Gonzalez, Jose Maria; Mattera, Rafael; Deborde, Sylvie; Banfelder, Jason R.; Bonifacino, Juan S.; Rodriguez-Boulan, Enrique

    2013-01-01

    Summary Clathrin and the epithelial-specific clathrin adaptor AP-1B mediate basolateral trafficking in epithelia. However, several epithelia lack AP-1B and mice knocked-out for AP-1B are viable, suggesting the existence of additional mechanisms that control basolateral polarity. Here, we demonstrate a distinct role of the ubiquitous clathrin adaptor AP-1A in basolateral protein sorting. Knock-down of AP-1A causes missorting of basolateral proteins in MDCK cells but only after knock-down of AP-1B, suggesting that AP-1B can compensate for lack of AP-1A. AP-1A localizes predominantly to the TGN and its knock-down promotes spillover of basolateral proteins into common recycling endosomes, the site of function of AP-1B, suggesting complementary roles of both adaptors in basolateral sorting. Yeast two-hybrid assays detect interactions between the basolateral signal of TfR and the medium subunits of both AP-1A and AP-1B. The basolateral sorting function of AP-1A reported here establishes AP-1 as a major regulator of epithelial polarity. PMID:22516199

  20. Functional description of APS beamline front ends

    SciTech Connect

    Kuzay, T.

    1993-02-01

    Traditional synchrotron sources were designed to produce bending magnet radiation and have proven to be an essential scientific tool. Currently, a new generation of synchrotron sources is being built that will be able to accommodate a large number of insertion device (ID) and high quality bending magnet (BM) sources. One example is the 7-GeV Advanced Photon Source (APS) now under construction at Argonne National Laboratory. The research and development effort at the APS is designed to fully develop the potential of this new generation of synchrotron sources. Of the 40 straight sections in the APS storage ring, 34 will be available for IDs. The remaining six sections are reserved for the storage ring hardware and diagnostics. Although the ring incorporates 80 BMs, only 40 of them can be used to extract radiation. The accelerator hardware shadows five of these 40 bending magnets, so the maximum number of BM sources on the lattice is 35. Generally, a photon beamline consists of four functional sections. The first section is the ID or the BM, which provides the radiation source. The second section, which is immediately outside the storage ring but inside a concrete shielding tunnel, is the front end, which is designed to control, define, and/or confine the x-ray beam. In the case of the APS, the front ends are designed to confine the photon beam. The third section, just outside the concrete shielding tunnel and on the experimental floor, is the first optics enclosure, which contains optics to filter and monochromatize the photon beam. The fourth section of a beamline consists of beam transports, additional optics, and experiment stations to do the scientific investigations. This document describes only the front ends of the APS beamlines.

  1. Tank 241-AP-106, grab samples, 6AP-96-1 through 6AP-96-3 analytical results for the final report

    SciTech Connect

    Esch, R.A., Westinghouse Hanford

    1996-12-11

    This document is the final report for tank 241-AP-106 grab samples. This document presents the analytical results for three samples (6AP-96-1, 6AP-96-2 and 6AP-96-3) taken from riser 1 @ 150{degrees} of tank 241-AP-1 06 on September 12, 1996. Analyses were performed in accordance with the Compatibility Grab Sampling and Analysis Plan (TSAP) (Sasaki, 1996) and the Data Quality Objectives for Tank Farms Waste Compatibility Program (DQO) (Fowler, 1995).

  2. Be Prepared to Meet the Press.

    ERIC Educational Resources Information Center

    Pedro, Nick J.

    1989-01-01

    Offers school administrators tips for sharpening their public relations skills. Educators interviewed by the press should do research beforehand, answer practice questions, listen before speaking, admit ignorance, make every statement count, be circumspect, ask for a review copy, attend to follow-up, keep a clipping file, and maintain open…

  3. Fair Trials and Free Press. Student Forum.

    ERIC Educational Resources Information Center

    Mertz, Gayle

    1997-01-01

    Outlines a role play that highlights the potential conflict between freedom of the press and the rights of defendants and victims. Students assume the roles of representative characters (police chief, newspaper editor) in a small town where a sensational murder has occurred. They also conduct a class discussion. (MJP)

  4. The Press and the Bolivian National Revolution.

    ERIC Educational Resources Information Center

    Knudson, Jerry W.

    1973-01-01

    Social revolutions, which frequently use the press as a propaganda weapon, have been rare in Latin America despite the striking social inequalities of the region. Only three classic socioeconomic revolutions have unfolded in the hemisphere--in Mexico in 1910, in Bolivia in 1952, and in Cuba in 1959. Bolivia attempted to effect radical reforms…

  5. The Measurement of Classroom Environmental Press.

    ERIC Educational Resources Information Center

    Walker, William J.; Stern, George G.

    The purpose of this research was to conduct a preliminary analysis of a new instrument, the Classroom Environment Index (CEI), designed to measure the psychological environment (press) of the classroom. The structure was essentially the same as other Syracuse indexes, containing 30 scales of 10 items each. Three forms of the instrument were

  6. Does Science Get the Press It Deserves?

    ERIC Educational Resources Information Center

    Wilkie, Tom

    1991-01-01

    Discusses concerns about public understanding of science in the United Kingdom in relation to structure and content of newspapers, particularly the inadequacy of the press to be a vehicle for promoting scientific literacy within the citizenry. Argues that changes in science coverage by the media must originate from the scientific community with…

  7. Neo-Lysenkoism, IQ, and the Press.

    ERIC Educational Resources Information Center

    Davis, Bernard D.

    1983-01-01

    In "The Mismeasure of Man," a history of efforts to measure intelligence, Stephen Jay Gould is highly selective in his account, and tests for scientific truth by the standards of his own social and political convictions. Specifically, to combat racist approaches to theories of intelligence, Gould presses for equal and opposite bias. (Author/GC)

  8. "Hands On" Index & Back Issues, Foxfire Press.

    ERIC Educational Resources Information Center

    Hands On, 1995

    1995-01-01

    Information on four articles offered through the Foxfire Press includes author, title, grade level, curriculum area, description, and number of pages. An index to 20 issues of "Hands On" organizes articles by grade level and includes author, title, issue number, pages, curriculum area, student population, setting, focus, and issue date. Includes…

  9. The Press, Privacy, and Community Mores.

    ERIC Educational Resources Information Center

    Glasser, Theodore L.

    Because of judicial indifference and legislative inaction, the conflict between the right of privacy and the freedom of the press is no closer to a resolution than it was a century ago. William Prosser's reduction of the common law of privacy into four separate torts has not solved the problem. The concept of "newsworthiness" has not been helpful…

  10. [Report from the Student Press Law Center.

    ERIC Educational Resources Information Center

    Student Press Law Center, Washington, DC.

    The Student Press Law Center serves as a national clearinghouse to collect, analyze, and distribute information on the First Amendment rights of student journalists and journalism teachers and on violations of these rights in high schools and colleges. This report details information concerning current censorship incidents: the investigation by…

  11. An Introduction to Bibliographical Press Work.

    ERIC Educational Resources Information Center

    Richardson, John V., Jr.

    This guide to the literature of bibliographical press work is comprised of brief introductory notes on the field and this bibliography, followed by citations listed in seven categories: (1) book production, (2) handmade paper, (3) printer's ink, (4) type design, (5) book design, (6) hand printing, and (7) hand bookbinding. Introductory as well as…

  12. Free Press in a Constitutional Democracy

    ERIC Educational Resources Information Center

    Lucianek, Christine

    2014-01-01

    This article describes a lesson in which students will examine several views expressed by the founders to understand the context for including freedom of the press in the First Amendment. Students will be asked to think about the role that the news media and the need to be an informed citizen continue to play in our democracy. Students will…

  13. The Moral Universes of Libertarian Press Theory.

    ERIC Educational Resources Information Center

    Wuliger, Gregory T.

    1991-01-01

    Uses Kantian logic to analyze the statement of Libertarian press theory "Truth beats falsehood in a free marketplace of ideas" as a definition, an observation, and a universal truth. Notes three corresponding moral universes, with differing ethical obligations. Discusses strengths and weaknesses of each. Cautions media ethics analysts against…

  14. When International Press Rights "Are" the News

    ERIC Educational Resources Information Center

    Freedman, Eric

    2006-01-01

    In many countries, reporters and editors face criminal prosecution, censorship, self-censorship, exile, tax audits, loss of broadcast and publication licenses, loss of jobs, assault, and even assassination based on how they practice their profession. Press rights and human rights advocacy groups try to draw media and official attention to those

  15. Holding fixture for a hot stamping press

    NASA Technical Reports Server (NTRS)

    Harris, R. P. (Inventor)

    1983-01-01

    A hand held guide for manually positioning a work piece between the anvil rib and tool of a hot die stamping press is described. A groove completed by interchangeable cover plates attached at one end of the guide conforms to a cross sectional dimension common to similar workpieces and, with a force fit, retentively holds each of the workpieces.

  16. [Report from the Student Press Law Center.

    ERIC Educational Resources Information Center

    Student Press Law Center, Washington, DC.

    The Student Press Law Center serves as a national clearinghouse to collect, analyze, and distribute information on the First Amendment rights of student journalists and journalism teachers and on violations of these rights in high schools and colleges. This report details information concerning current censorship incidents: the investigation by

  17. Warren G. Harding and the Press.

    ERIC Educational Resources Information Center

    Whitaker, W. Richard

    There are many parallels between the Richard M. Nixon administration and Warren G. Harding's term: both Republicans, both touched by scandal, and both having a unique relationship with the press. But in Harding's case the relationship was a positive one. One of Harding's first official acts as president was to restore the regular White House news…

  18. The Press Conferences of Eleanor Roosevelt.

    ERIC Educational Resources Information Center

    Beasley, Maurine H.

    Newly discovered transcriptions of 87 of First Lady Eleanor Roosevelt's women-only press conferences held from 1933 to 1945 make possible an examination of the objectives, topics, and value of these conferences. By holding the conferences, Mrs. Roosevelt attributed to women an important function in the political communication process, and at the…

  19. Brownsville: The Reaction of the Negro Press

    ERIC Educational Resources Information Center

    Wynne, Lewis N.

    1972-01-01

    Describes the events that followed subsequent to the assignment of an all-black regimental unit to the Fort Brown military installation on the outskirts of Brownsville, Texas, in 1906, with reference to the reactions of the Brownsville residents, the Negro press, and white champions of the black cause, and to the actions of President Theodore…

  20. Metrics for Offset Printing Press Operation.

    ERIC Educational Resources Information Center

    Cooper, Gloria S., Ed.; Magisos, Joel H., Ed.

    Designed to meet the job-related metric measurement needs of offset printing press operation students, this instructional package is one of six for the communication media occupations cluster, part of a set of 55 packages for metric instruction in different occupations. The package is intended for students who already know the occupational

  1. Research Review: The Specialized Business Press.

    ERIC Educational Resources Information Center

    Endres, Kathleen L.

    1994-01-01

    Reviews scholarly research (from journalism, communication, business, and the humanities) on the specialized business press. Notes the lack of theory building and ties across disciplines, and anticipates that new advances in CD-ROM technology may increase research into the field as well as strengthen ties across disciplines. (SR)

  2. Communications in Agriculture: The American Farm Press.

    ERIC Educational Resources Information Center

    Evans, James F.; Salcedo, Rodolfo N.

    This book studies communications in agriculture, focusing on the American farm press. As defined here, a commercial farm periodical is directed to farmers and supports itself through the sale of subscriptions or advertising. It includes local as well as regional and national periodicals. A 90-year analysis, from 1880 to 1970, was chosen because…

  3. Student Press Corps (Use the News).

    ERIC Educational Resources Information Center

    Mahler, Susan

    1989-01-01

    Describes the Student Press Corps, a program in which high school students submit weekly columns concerning local high school events for editing and possible publication by the local newspaper. Reports that training sessions have been fully enrolled for two years and that all participants are extremely positive about the program. (RS)

  4. Law of the Student Press. Second Edition.

    ERIC Educational Resources Information Center

    Student Press Law Center, Washington, DC.

    Noting dramatic changes in First Amendment protections for high school students and new legal issues facing college newspaper editors, this book describes in detail the legal rights and responsibilities of both the high school and college press. While the book is extensively footnoted, it intentionally avoids "legal-ese" and "brings law to life"…

  5. When International Press Rights "Are" the News

    ERIC Educational Resources Information Center

    Freedman, Eric

    2006-01-01

    In many countries, reporters and editors face criminal prosecution, censorship, self-censorship, exile, tax audits, loss of broadcast and publication licenses, loss of jobs, assault, and even assassination based on how they practice their profession. Press rights and human rights advocacy groups try to draw media and official attention to those…

  6. STS-9 Spacelab 1 Press Kit

    NASA Technical Reports Server (NTRS)

    1983-01-01

    Press information on the STS-9/SPACELAB 1 mission is provided. Launch preparations, launch window, flight objectives, experiments, life sciences baseline data collection, SPACELAB 1 payload operations and control crew and specialists, and tracking and data management are among the topics explained.

  7. Power Saving Control for Battery-Powered Portable WLAN APs

    NASA Astrophysics Data System (ADS)

    Ogawa, Masakatsu; Hiraguri, Takefumi

    This paper proposes a power saving control function for battery-powered portable wireless LAN (WLAN) access points (APs) to extend the battery life. The IEEE802.11 standard does not support power saving control for APs. To enable a sleep state for an AP, the AP forces the stations (STAs) to refrain from transmitting frames using the network allocation vector (NAV) while the AP is sleeping. Thus the sleep state for the AP can be employed without causing frame loss at the STAs. Numerical analysis and computer simulation reveal that the newly proposed control technique conserves power compared to the conventional control.

  8. Greenhouse evaluation of Bacillus subtilis AP-01 and Trichoderma harzianum AP-001 in controlling tobacco diseases

    PubMed Central

    Maketon, Monchan; Apisitsantikul, Jirasak; Siriraweekul, Chatchai

    2008-01-01

    Two biological control agents, Bacillus subtilis AP-01 (Larminar™) and Trichoderma harzianum AP-001 (Trisan™) alone or/in combination were investigated in controlling three tobacco diseases, including bacterial wilt (Ralstonia solanacearum), damping-off (Pythium aphanidermatum), and frogeye leaf spot (Cercospora nicotiana). Tests were performed in greenhouse by soil sterilization prior to inoculation of the pathogens. Bacterial-wilt and damping off pathogens were drenched first and followed with the biological control agents and for comparison purposes, two chemical fungicides. But for frogeye leaf spot, which is an airborne fungus, a spraying procedure for every treatment including a chemical fungicide was applied instead of drenching. Results showed that neither B. subtilis AP-01 nor T harzianum AP-001 alone could control the bacterial wilt, but when combined, their controlling capabilities were as effective as a chemical treatment. These results were also similar for damping-off disease when used in combination. In addition, the combined B. subtilis AP-01 and T. harzianum AP-001 resulted in a good frogeye leaf spot control, which was not significantly different from the chemical treatment. PMID:24031219

  9. Kiln for hot-pressing compacts in a continuous manner

    DOEpatents

    Reynolds, Jr., Carl D.

    1985-01-01

    The present invention is directed to a hot pressing furnace or kiln which is capable of preheating, hot pressing, and cooling a plurality of articles in a sequential and continuous manner. The hot pressing furnace of the present invention comprises an elongated, horizontally disposed furnace capable of holding a plurality of displaceable pusher plates each supporting a die body loaded with refractory or ceramic material to be hot pressed. Each of these plates and the die body supported thereby is sequentially pushed through the preheating zone, a temperature stabilizing and a hot pressing zone, and a cooling zone so as to provide a continuous hot-pressing operation of a plurality of articles.

  10. Kiln for hot-pressing compacts in a continuous manner

    DOEpatents

    Reynolds, C.D Jr.

    1983-08-08

    The invention is directed to a hot pressing furnace or kiln which is capable of preheating, hot pressing, and cooling a plurality of articles in a sequential and continuous manner. The hot pressing furnace of the present invention comprises an elongated, horizontally disposed furnace capable of holding a plurality of displaceable pusher plates each supporting a die body loaded with refractory or ceramic material to be hot pressed. Each of these plates and the die body supported thereby is sequentially pushed through the preheating zone, a temperature stabilizing and a hot pressing zone, and a cooling zone so as to provide a continuous hot-pressing operation of a plurality of articles.

  11. Control of Ca2+ Release by Action Potential Configuration in Normal and Failing Murine Cardiomyocytes

    PubMed Central

    Louch, William E.; Hake, Johan; Jølle, Guro Five; Mørk, Halvor K.; Sjaastad, Ivar; Lines, Glenn T.; Sejersted, Ole M.

    2010-01-01

    Cardiomyocytes from failing hearts exhibit spatially nonuniform or dyssynchronous sarcoplasmic reticulum (SR) Ca2+ release. We investigated the contribution of action potential (AP) prolongation in mice with congestive heart failure (CHF) after myocardial infarction. AP recordings from CHF and control myocytes were included in a computational model of the dyad, which predicted more dyssynchronous ryanodine receptor opening during stimulation with the CHF AP. This prediction was confirmed in cardiomyocyte experiments, when cells were alternately stimulated by control and CHF AP voltage-clamp waveforms. However, when a train of like APs was used as the voltage stimulus, the control and CHF AP produced a similar Ca2+ release pattern. In this steady-state condition, greater integrated Ca2+ entry during the CHF AP lead to increased SR Ca2+ content. A resulting increase in ryanodine receptor sensitivity synchronized SR Ca2+ release in the mathematical model, thus offsetting the desynchronizing effects of reduced driving force for Ca2+ entry. A modest nondyssynchronous prolongation of Ca2+ release was nevertheless observed during the steady-state CHF AP, which contributed to increased time-to-peak measurements for Ca2+ transients in failing cells. Thus, dyssynchronous Ca2+ release in failing mouse myocytes does not result from electrical remodeling, but rather other alterations such as T-tubule reorganization. PMID:20816049

  12. ADP-ribosylation factor 1 transiently activates high-affinity adaptor protein complex AP-1 binding sites on Golgi membranes.

    PubMed

    Zhu, Y; Traub, L M; Kornfeld, S

    1998-06-01

    Association of the Golgi-specific adaptor protein complex 1 (AP-1) with the membrane is a prerequisite for clathrin coat assembly on the trans-Golgi network (TGN). The AP-1 adaptor is efficiently recruited from cytosol onto the TGN by myristoylated ADP-ribosylation factor 1 (ARF1) in the presence of the poorly hydrolyzable GTP analog guanosine 5'-O-(3-thiotriphosphate) (GTPgammaS). Substituting GTP for GTPgammaS, however, results in only poor AP-1 binding. Here we show that both AP-1 and clathrin can be recruited efficiently onto the TGN in the presence of GTP when cytosol is supplemented with ARF1. Optimal recruitment occurs at 4 microM ARF1 and with 1 mM GTP. The AP-1 recruited by ARF1.GTP is released from the Golgi membrane by treatment with 1 M Tris-HCl (pH 7) or upon reincubation at 37 degreesC, whereas AP-1 recruited with GTPgammaS or by a constitutively active point mutant, ARF1(Q71L), remains membrane bound after either treatment. An incubation performed with added ARF1, GTP, and AlFn, used to block ARF GTPase-activating protein activity, results in membrane-associated AP-1, which is largely insensitive to Tris extraction. Thus, ARF1. GTP hydrolysis results in lower-affinity binding of AP-1 to the TGN. Using two-stage assays in which ARF1.GTP first primes the Golgi membrane at 37 degreesC, followed by AP-1 binding on ice, we find that the high-affinity nucleating sites generated in the priming stage are rapidly lost. In addition, the AP-1 bound to primed Golgi membranes during a second-stage incubation on ice is fully sensitive to Tris extraction, indicating that the priming stage has passed the ARF1.GTP hydrolysis point. Thus, hydrolysis of ARF1.GTP at the priming sites can occur even before AP-1 binding. Our finding that purified clathrin-coated vesicles contain little ARF1 supports the concept that ARF1 functions in the coat assembly process rather than during the vesicle-uncoating step. We conclude that ARF1 is a limiting factor in the GTP-stimulated recruitment of AP-1 in vitro and that it appears to function in a stoichiometric manner to generate high-affinity AP-1 binding sites that have a relatively short half-life. PMID:9614177

  13. Small Molecule Inhibitors Targeting Activator Protein 1 (AP-1)

    PubMed Central

    2015-01-01

    Activator protein 1 (AP-1) is a pivotal transcription factor that regulates a wide range of cellular processes including proliferation, apoptosis, differentiation, survival, cell migration, and transformation. Accumulating evidence supports that AP-1 plays an important role in several severe disorders including cancer, fibrosis, and organ injury, as well as inflammatory disorders such as asthma, psoriasis, and rheumatoid arthritis. AP-1 has emerged as an actively pursued drug discovery target over the past decade. Excitingly, a selective AP-1 inhibitor T-5224 (51) has been investigated in phase II human clinical trials. Nevertheless, no effective AP-1 inhibitors have yet been approved for clinical use. Despite significant advances achieved in understanding AP-1 biology and function, as well as the identification of small molecules modulating AP-1 associated signaling pathways, medicinal chemistry efforts remain an urgent need to yield selective and efficacious AP-1 inhibitors as a viable therapeutic strategy for human diseases. PMID:24831826

  14. Correction magnet power supplies for APS machine

    SciTech Connect

    Kang, Y.G.

    1991-01-01

    The Advanced Photon Source machine requires a number of correction magnets; five kinds for the storage ring, two for the injector synchrotron, and two for the positron accumulator ring. Three types of bipolar power supply will be used for all the correction magnets. This paper describes the design aspects and considerations for correction magnet power supplies for the APS machine. 3 refs., 3 figs., 1 tab.

  15. An Updated AP2 Beamline TURTLE Model

    SciTech Connect

    Gormley, M.; O'Day, S.

    1991-08-23

    This note describes a TURTLE model of the AP2 beamline. This model was created by D. Johnson and improved by J. Hangst. The authors of this note have made additional improvements which reflect recent element and magnet setting changes. The magnet characteristics measurements and survey data compiled to update the model will be presented. A printout of the actual TURTLE deck may be found in appendix A.

  16. Final report for tank 241-AP-108, grab samples 8AP-96-1, 8AP-96-2 and 8AP-96-FB

    SciTech Connect

    Esch, R.A.

    1996-04-19

    This document is the final report deliverable for the tank 241-AP-108 grab samples. The samples were subsampled and analyzed in accordance with the TSAP. Included in this report are the results for the Waste Compatibility analyses, with the exception of DSC and thermogravimetric analysis (TGA) results which were presented in the 45 Day report (Part 2 of this document). The raw data for all analyses, with the exception of DSC and TGA, are also included in this report.

  17. Cultural Diversity in AP Art History

    ERIC Educational Resources Information Center

    Bolte, Frances R.

    2006-01-01

    Teaching AP Art History is like running on a treadmill that is moving faster than a teacher can run. Many teachers are out of breath before the end of the term and wonder how in the world they can cover every chapter. Because time is short and art from pre-history through to the present, including the non-European traditions, must be covered, this…

  18. Cultural Diversity in AP Art History

    ERIC Educational Resources Information Center

    Bolte, Frances R.

    2006-01-01

    Teaching AP Art History is like running on a treadmill that is moving faster than a teacher can run. Many teachers are out of breath before the end of the term and wonder how in the world they can cover every chapter. Because time is short and art from pre-history through to the present, including the non-European traditions, must be covered, this

  19. The Cryptosporidium parvum ApiAP2 gene family: insights into the evolution of apicomplexan AP2 regulatory systems

    PubMed Central

    Oberstaller, Jenna; Pumpalova, Yoanna; Schieler, Ariel; Llins, Manuel; Kissinger, Jessica C.

    2014-01-01

    We provide the first comprehensive analysis of any transcription factor family in Cryptosporidium, a basal-branching apicomplexan that is the second leading cause of infant diarrhea globally. AP2 domain-containing proteins have evolved to be the major regulatory family in the phylum to the exclusion of canonical regulators. We show that apicomplexan and perkinsid AP2 domains cluster distinctly from other chromalveolate AP2s. Protein-binding specificity assays of C. parvum AP2 domains combined with motif conservation upstream of co-regulated gene clusters allowed the construction of putative AP2 regulons across the in vitro life cycle. Orthologous Apicomplexan AP2 (ApiAP2) expression has been rearranged relative to the malaria parasite P. falciparum, suggesting ApiAP2 network rewiring during evolution. C. hominis orthologs of putative C. parvum ApiAP2 proteins and target genes show greater than average variation. C. parvum AP2 domains display reduced binding diversity relative to P. falciparum, with multiple domains binding the 5?-TGCAT-3?, 5?-CACACA-3? and G-box motifs (5?-G[T/C]GGGG-3?). Many overrepresented motifs in C. parvum upstream regions are not AP2 binding motifs. We propose that C. parvum is less reliant on ApiAP2 regulators in part because it utilizes E2F/DP1 transcription factors. C. parvum may provide clues to the ancestral state of apicomplexan transcriptional regulation, pre-AP2 domination. PMID:24957599

  20. AP stars with resolved magnetically split lines

    NASA Astrophysics Data System (ADS)

    Mathys, G.; Lanz, T.

    1992-03-01

    New high-resolution spectroscopic observations of Ap stars with resolved magnetically split spectral lines are presented. Six new such stars have been discovered: HD 2453, HD 9996, HD 18078, HD 50169, HD 137949, and HD 192678. This raises the total number of known Ap stars with resolved magnetically split lines to 21. The spectral line profiles observed in two more stars, HD 111133 and HD 147010, are strongly affected by the magnetic field, but they are not fully resolved, due to nonnegligible rotational Doppler effect. Observations of fairly sharp-lined Ap stars whose lines are unresolved are also presented. The relative difference between the equivalent widths of the Fe II lines 6147.7 A and 6149.2 A is shown to increase with the mean magnetic field modulus. The existence of a simple, unambiguous correlation between the mean magnetic field modulus and the index Z of Geneva photometry, which had previously been advocated, is not confirmed. At most, stars with large negative values of Z may be more prone to have strong magnetic fields, but the evidence for this is not statistically strong.

  1. Book Eyes Impact of AP Classes and Exams

    ERIC Educational Resources Information Center

    Viadero, Debra

    2010-01-01

    At a time of mushrooming interest in Advanced Placement (AP) tests, a new book, "AP: A Critical Examination of the Advanced Placement Program," assembles studies on how capable the program is of meeting the increasingly diverse expectations held up for it. Growing out of a symposium held at Harvard in 2007, the book focuses on AP science courses…

  2. 9. INTERIOR VIEW OF EYE PRESS AREA; TO LEFT IS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. INTERIOR VIEW OF EYE PRESS AREA; TO LEFT IS A TWO-BAY SLOTTED TYPE FURNACE, TO CENTER IS EYE PRESS, TO RIGHT IS CURCULAR SAW - Warwood Tool Company, Foot of Nineteenth Street, Wheeling, Ohio County, WV

  3. Method for hot pressing beryllium oxide articles

    DOEpatents

    Ballard, Ambrose H.; Godfrey, Jr., Thomas G.; Mowery, Erb H.

    1988-01-01

    The hot pressing of beryllium oxide powder into high density compacts with little or no density gradients is achieved by employing a homogeneous blend of beryllium oxide powder with a lithium oxide sintering agent. The lithium oxide sintering agent is uniformly dispersed throughout the beryllium oxide powder by mixing lithium hydroxide in an aqueous solution with beryllium oxide powder. The lithium hydroxide is converted in situ to lithium carbonate by contacting or flooding the beryllium oxide-lithium hydroxide blend with a stream of carbon dioxide. The lithium carbonate is converted to lithium oxide while remaining fixed to the beryllium oxide particles during the hot pressing step to assure uniform density throughout the compact.

  4. Reducing VOC Press Emission from OSB Manufacturing

    SciTech Connect

    Dr. Gary D. McGinnis; Laura S. WIlliams; Amy E. Monte; Jagdish Rughani: Brett A. Niemi; Thomas M. Flicker

    2001-12-31

    Current regulations require industry to meet air emission standards with regard to particulates, volatile organic compounds (VOCs), hazardous air pollutants (HAPs) and other gases. One of many industries that will be affected by the new regulations is the wood composites industry. This industry generates VOCs, HAPs, and particulates mainly during the drying and pressing of wood. Current air treatment technologies for the industry are expensive to install and operate. As regulations become more stringent, treatment technologies will need to become more efficient and cost effective. The overall objective of this study is to evaluate the use of process conditions and chemical additives to reduce VOC/HAPs in air emitted from presses and dryers during the production of oriented strand board.

  5. Magellan Press Conference (2 of 2)

    NASA Technical Reports Server (NTRS)

    1990-01-01

    Live footage shows the speakers participating in the Magellan Press Conference question and answer session. Speakers include Huntress, Spear, Ledbetter, Johnson, McCarthy, and Saunders. The speakers are shown answering questions from various NASA Centers, and participating audience members from many different industries. They discuss the start and stop date for the mapping. Also shown are animation and radar images of Venus and Artemis. This is tape 2 of 2; tape 1 has a report number NONP-NASA-VT-2000036552.

  6. Magellan Press Conference (2 of 2)

    NASA Astrophysics Data System (ADS)

    1991-10-01

    Live footage shows the speakers participating in the Magellan Press Conference question and answer session. Speakers include Huntress, Spear, Ledbetter, Johnson, McCarthy, and Saunders. The speakers are shown answering questions from various NASA Centers, and participating audience members from many different industries. They discuss the start and stop date for the mapping. Also shown are animation and radar images of Venus and Artemis. This is tape 2 of 2; tape 1 has a report number NONP-NASA-VT-2000036552.

  7. Magellan Press Conference (2 of 2)

    NASA Technical Reports Server (NTRS)

    1991-01-01

    Live footage shows the speakers participating in the Magellan Press Conference question and answer session. Speakers include Huntress, Spear, Ledbetter, Johnson, McCarthy, and Saunders. The speakers are shown answering questions from various NASA Centers, and participating audience members from many different industries. They discuss the start and stop date for the mapping. Also shown are animation and radar images of Venus and Artemis. This is tape 2 of 2; tape 1 has a report number NONP-NASA-VT-2000036552.

  8. You Cannot Press Out the Black Hole

    NASA Astrophysics Data System (ADS)

    Ida, D.; Okamoto, T.

    2012-01-01

    It is shown that a ball-shaped black hole region homeomorphic with D^n cannot be pressed out, along whichever axis penetrating the black hole region, into a black ring with a doughnut-shaped black hole region homeomorphic with S^1 × D^{n-1}. A more general prohibition law for the change of the topology of black holes, including a version of no-bifurcation theorems for black holes, is given.

  9. Chemical releases

    NASA Technical Reports Server (NTRS)

    Heppner, J. P.; Evans, D. S.

    1978-01-01

    A Chemical Release Module to be carried into orbit by the shuttle is described. The module would release chemicals from orbiting satellites in order understand processes within the Earth's magnetosphere, atmosphere and ionosphere. A large number of potential experiments are identified, ranging from introducing traceable material into the solar wind in order to study its transport to and within the magnetosphere, to injecting material into the outer magnetosphere to simulate the precipitation of trapped charged particles, to the release of material at lower altitudes to create waves both mechanical and electromagnetic.

  10. The American Native Press and American Indian Studies.

    ERIC Educational Resources Information Center

    Littlefield, Daniel F., Jr.

    1986-01-01

    As product and process, the Native American press has a long history. The establishment of the first native-run press in 1828 began a press history that continues today. That history is represented by more than 2,000 periodical titles alone, two-thirds of which have been established during the past 20 years. Impressive collections of these…

  11. Through the Looking Glass: Press Responses to Genocide.

    ERIC Educational Resources Information Center

    Lipstadt, Deborah E.

    1991-01-01

    Examines press coverage of the Holocaust to analyze the response of the United States and the world to the Jewish extermination. Compares this coverage to earlier press responses to the Armenian genocide and Ukraine famines. Argues the press was unwilling to face the Holocaust's magnitude. Urges teachers to teach about the Holocaust and similar…

  12. The Rice University Press Initiative: An Interview with Charles Henry

    ERIC Educational Resources Information Center

    Trevitte, Chad; Henry, Charles

    2007-01-01

    In this interview Charles Henry, publisher of the Rice University Press (RUP), discusses RUP's rebirth as a fully digital university press. Henry addresses the circumstances that led to this decision, and he further outlines the RUP business model whereby the press will publish its own titles--both digitally and in print-on-demand--while…

  13. Living Dangerously--Changing Press Law in India.

    ERIC Educational Resources Information Center

    Ryan, Timothy

    An examination of the changes in press laws after India gained its independence in 1947 shows how a free press is shaped mostly by the structure and evolution of the democratic society that it is intended to serve. The most salient features that have characterized the Indian press, from the early nineteenth century to the present day, are…

  14. Graphic Arts: The Press and Finishing Processes. Third Edition.

    ERIC Educational Resources Information Center

    Crummett, Dan

    This document contains teacher and student materials for a course in graphic arts concentrating on printing presses and the finishing process for publications. Seven units of instruction cover the following topics: (1) offset press systems; (2) offset inks and dampening chemistry; (3) offset press operating procedures; (4) preventive maintenance

  15. Graphic Arts: The Press and Finishing Processes. Third Edition.

    ERIC Educational Resources Information Center

    Crummett, Dan

    This document contains teacher and student materials for a course in graphic arts concentrating on printing presses and the finishing process for publications. Seven units of instruction cover the following topics: (1) offset press systems; (2) offset inks and dampening chemistry; (3) offset press operating procedures; (4) preventive maintenance…

  16. Lesquerella Press Cake as an Organic Fertilizer for Greenhouse Tomatoes

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Lesquerella press cake is a co-product generated during the processing of the new oilseed crop lesquerella [Lesquerella fendleri (A. Gray) S. Wats.]. As with other new crops, developing commercial uses for the press cake would increase the profitability of growing lesquerella. The press cake conta...

  17. Lesquerella Press Cake as an Organic Fertilizer for Greenhouse Tomatoes

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Lesquerella press cake is a co-product generated during the processing of the new oilseed crop lesquerella [Lesquerella fendleri (A. Gray) S. Wats.]. Developing commercial uses for the press cake would increase the profitability of growing lesquerella. The press cake contains levels of nutrients w...

  18. 77 FR 24480 - Application for New Awards; Advanced Placement (AP) Test Fee Program-Reopening the AP Test Fee...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-24

    .... ACTION: Notice reopening the AP Test Fee fiscal year 2012 competition. Catalog of Federal Domestic Assistance (CFDA) Number: 84.330B. SUMMARY: On February 15, 2012, we published in the Federal Register (77 FR... Application for New Awards; Advanced Placement (AP) Test Fee Program--Reopening the AP Test Fee Fiscal...

  19. RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway

    PubMed Central

    Asensio, Cdric S.; Sirkis, Daniel W.

    2010-01-01

    The regulated release of proteins depends on their inclusion within large dense-core vesicles (LDCVs) capable of regulated exocytosis. LDCVs form at the trans-Golgi network (TGN), but the mechanism for protein sorting to this regulated secretory pathway (RSP) and the cytosolic machinery involved in this process have remained poorly understood. Using an RNA interference screen in Drosophila melanogaster S2 cells, we now identify a small number of genes, including several subunits of the heterotetrameric adaptor protein AP-3, which are required for sorting to the RSP. In mammalian neuroendocrine cells, loss of AP-3 dysregulates exocytosis due to a primary defect in LDCV formation. Previous work implicated AP-3 in the endocytic pathway, but we find that AP-3 promotes sorting to the RSP within the biosynthetic pathway at the level of the TGN. Although vesicles with a dense core still form in the absence of AP-3, they contain substantially less synaptotagmin 1, indicating that AP-3 concentrates the proteins required for regulated exocytosis. PMID:21149569

  20. Science Education Reform and the Education Programs of the APS

    NASA Astrophysics Data System (ADS)

    Lopez, Ramon

    1998-11-01

    Science education in America is undergoing its greatest period of change since attempt at large-scale reforms in the 60s and 70s. APS members strongly believe that the APS should be involved in precollege science education reform, and the recent membership survey ranked this as the highest priority item for the APS. At the same time, many members are unaware of APS education initiatives. In this talk I will provide an overview of science education reform in the US today. I will then describe APS efforts to support reform in school systems around the country, as well as other APS education programs. APS members have played an active role in all of these programs. If science education reform is to succeed and make a lasting change in schools, the scientific community must be informed and engaged.

  1. The Inter American Press Association as Champion of Press Freedom: Reality or Rhetoric? The Bolivian Experience, 1952-1973.

    ERIC Educational Resources Information Center

    Knudson, Jerry W.

    Each year a committee on freedom of the press, established in 1946 by the Inter American Press Association (IAPA), exposes those countries which it feels do not have freedom of the press. In 1952 Bolivia underwent a social and economic revolution. As a result, angry mobs forced the closure of the two newspapers with the largest circulation in…

  2. Crack-Free, Nondistorting Can For Hot Isostatic Pressing

    NASA Technical Reports Server (NTRS)

    Juhas, John J.

    1991-01-01

    New method of canning specimens made of composites of arc-sprayed and plasma-sprayed tape reduces outgassing and warping during hot isostatic pressing. Produces can having reliable, crack-free seal and thereby helps to ensure pressed product of high quality. Specimen placed in ring of refractory metal between two face sheets, also of refractory metal. Assembly placed in die in vacuum hot press, where simultaneously heated and pressed until plates become diffusion-welded to ring, forming sealed can around specimen. Specimen becomes partially densified, and fits snugly within can. Ready for further densification by hot isostatic pressing.

  3. [Exploration on the origin and development of pressing moxibustion].

    PubMed

    Tang, Yi-Chun; Zhang, Jian-Bin

    2012-09-01

    Through arranging of ancient books and literatures related pressing moxibustion, the history along with origin and development of pressing moxibustion is systematically investigated and analyzed, which provided theoretical basis for the clinical practice of pressing moxibustion. It is found that after 600 years of development and innovation, pressing moxibustion already has complete theoretical system which is reflected in the unitarity of formulating prescription, the diversity of the manipulation the universality of indications. What's more, the functional characteristics and mechanism of pressing moxibustion are initially discussed and its present research status and prospect in the field of modern moxibustion are revealed. PMID:23227702

  4. The APS machine protection system (MPS)

    SciTech Connect

    Fuja, R.; Berg, B.; Arnold, N.

    1996-08-01

    The machine protection system (MPS) that protects the APS storage ring vacuum chamber from x-ray beams, is active. There are over 650 sensors monitored and networked through the MPS system. About the same number of other process variables are monitored by the much slower EPICS control system, which also has an input to the rf abort chain. The MPS network is still growing with the beam position limits detection system coming on-line. The network configuration, along with a limited description of individual subsystems, is presented.

  5. Ozone mitigation tests at the APS

    SciTech Connect

    Kuzay, T.M.; Collins, J.T.; Pisharody, M.; Job, P.K.; Wang Zhibi

    1996-09-01

    Ozone is generated in the APS experimental stations whenever the x-ray beam has a chance to interact with air. Ozone concentrations in an experimental station have to be below a certain defined limit (current OSHA regulations specify 0.08 ppm as the maximum limit) before an experimenter can reenter the hutch. This limit is said to be currently under study for a downward adjustment. One method of depleting the ozone generated in an experimental station is mitigation through either adsorption or direct destruction. In recent tests, both methods were tried using commercially available units. Test results and some analytical predictions are presented.

  6. Cold-fusion television show angers APS

    NASA Astrophysics Data System (ADS)

    Cartwright, Jon

    2009-06-01

    Cold fusion has been controversial since its inception on 23 March 1989, when chemists Martin Fleischmann and Stanley Pons at the University of Utah in the US announced that they had achieved a sustained nuclear-fusion reaction at room temperature. Two decades on, a US television documentary about the field has stirred up fresh debate after it linked the American Physical Society (APS) to an evaluation of some cold-fusion results by Robert Duncan, a physicist and vice chancellor of the University of Missouri.

  7. Effect of hot pressing additives on the leachability of hot pressed sodium hydrous titanium oxide

    SciTech Connect

    Valentine, T.M.; Sambell, R.A.J.

    1980-01-01

    Sodium hydrous titanium oxide is an ion exchange resin which can be used for immobilizing medium level waste (MLW) liquors. When hot pressed, it undergoes conversion to a ceramic. Three low melting point materials (borax, bismuth trioxide, and a mixture of PbO/CuO) were added to the (Na)HTiO and the effect that each of these had on aiding densification was assessed. Hot pressing temperature, applied pressure, and percentage addition of hot pressing aid were varied. Percentage open porosity, flexural strength, and leachability were measured. There was a linear relationship between the percentage open porosity and the logarithm of the leach rate for a constant percentage addition of each additive.

  8. The control of press cleaning solvent vapors in a small lithographic printing establishment

    SciTech Connect

    Crouch, K.G.; Gressel, M.G. . Div. of Physical Sciences and Engineering)

    1999-05-01

    Small businesses frequently have inadequate in-house expertise to solve a variety of safety and health problems. The National Institute for Occupational Safety and Health (NIOSH) has therefore conducted a demonstration project in the commercial lithographic printing industry, which consists largely of small companies, in a effort to establish suitable control technology for airborne solvent vapors released primarily during press cleaning operations. These solvent vapors have a number of potential adverse health effects, including narcosis, kidney and liver damage, and cancer. Also, airborne anti-offset powder is a potential allergic sensitizer and cause of occupational asthma. As a means of controlling worker exposures to the vapors and dust, a local exhaust inlet was attached to the side of the press adjacent to the paper delivery point. Tempered outside air was introduced through ceiling outlets installed to make up for the exhausted air. Measurements of press operator exposure and area concentrations of solvent vapors and area concentration of anti-offset powder were made before and after installation of the new ventilation controls. Vapor concentrations were reduced by 73% for the press operators. Area concentrations of the vapors were reduced by 86% and dust concentration by 67%. The ventilation system was found to be suitable for vapor and dust control, although substitution of a cleaning solution containing non-carcinogenic solvents for solutions containing carcinogens was recommended.

  9. The control of press cleaning solvent vapors in a small lithographic printing establishment.

    PubMed

    Crouch, K G; Gressel, M G

    1999-05-01

    Small businesses frequently have inadequate in-house expertise to solve a variety of safety and health problems. The National Institute for Occupational Safety and Health (NIOSH) has therefore conducted a demonstration project in the commercial lithographic printing industry, which consists largely of small companies, in an effort to establish suitable control technology for airborne solvent vapors released primarily during press cleaning operations. These solvent vapors have a number of potential adverse health effects, including narcosis, kidney and liver damage, and cancer. Also, airborne anti-offset powder is a potential allergic sensitizer and cause of occupational asthma. As a means of controlling worker exposures to the vapors and dust, a local exhaust inlet was attached to the side of the press adjacent to the paper delivery point. Tempered outside air was introduced through ceiling outlets installed to make up for the exhausted air. Measurements of press operator exposure and area concentrations of solvent vapors and area concentration of anti-offset powder were made before and after installation of the new ventilation controls. Vapor concentrations were reduced by 73 percent for the press operators. Area concentrations of the vapors were reduced by 86 percent and dust concentration by 67 percent. The ventilation system was found to be suitable for vapor and dust control, although substitution of a cleaning solution containing non-carcinogenic solvents for solutions containing carcinogens was recommended. PMID:10446485

  10. EX-PRESS Glaucoma Filtration Device: efficacy, safety, and predictability

    PubMed Central

    Chan, Jessica E; Netland, Peter A

    2015-01-01

    Trabeculectomy has been the traditional primary surgical therapy for open-angle glaucoma. While trabeculectomy is effective in lowering intraocular pressure, complications associated with the procedure have motivated the development of alternative techniques and devices, including the EX-PRESS Glaucoma Filtration Device. This review describes the efficacy, safety, complication rates, and potential advantages and disadvantages of the EX-PRESS Glaucoma Filtration Device. EX-PRESS implantation is technically simpler compared with that of trabeculectomy, with fewer surgical steps. Vision recovery has been more rapid after EX-PRESS implantation compared with trabeculectomy. Intraocular pressure variation is lower during the early postoperative period, indicating a more predictable procedure. While efficacy of the EX-PRESS implant has been comparable to trabeculectomy, postoperative complications appear less common after EX-PRESS implantation compared with trabeculectomy. The EX-PRESS Glaucoma Filtration Device appears to be safe and effective in the surgical management of open-angle glaucoma. PMID:26366105

  11. Toggle release

    NASA Technical Reports Server (NTRS)

    Graves, Thomas Joseph (Inventor); Yang, Robert Alexander (Inventor); Brown, Christopher William (Inventor)

    1988-01-01

    The invention relates to a pyrotechnic actuated release mechanism which is mechanically two fault tolerant for effecting release. It is particularly well suited for releasably connecting structures to be used in the space environment or in other aerospace applications. The device comprises a fastener plate and fastener body, each attachable to either one of a pair of structures to be joined. The fastener plate and the body are fastenable by a toggle supported at one end on the fastener plate and mounted for universal pivotal movement thereon. At its other end, which is received in a central opening in the fastener body and adapted for limited pivotal movement therein, the toggle is restrained by three retractable latching pins. Each pin is individually retractable by combustion of a pyrotechnic charge. While retraction of all three pins releases the toggle, the fastener is mechanically two fault tolerant since the failure of any single or pair of the latch pins to retract results in an asymmetrical loading on the toggle and its pivotal movement to effect a release. An annular bolt is mounted on the fastener plate as a support for the socket mounting of the toggle whereby its selective axial movement provides a means for pre-loading the toggle.

  12. Basolateral sorting of the Mg? transporter CNNM4 requires interaction with AP-1A and AP-1B.

    PubMed

    Hirata, Yusuke; Funato, Yosuke; Miki, Hiroaki

    2014-12-12

    Ancient conserved domain protein/cyclin M (CNNM) 4 is an evolutionarily conserved Mg(2+) transporter that localizes at the basolateral membrane of the intestinal epithelia. Here, we show the complementary importance of clathrin adaptor protein (AP) complexes AP-1A and AP-1B in basolateral sorting of CNNM4. We first confirmed the basolateral localization of both endogenous and ectopically expressed CNNM4 in Madin-Darby Canine Kidney cells, which form highly polarized epithelia in culture. Single knockdown of ?1B, a cargo-recognition subunit of AP-1B, did not affect basolateral localization, but simultaneous knockdown of the ?1A subunit of AP-1A abrogated localization. Mutational analyses showed the importance of three conserved dileucine motifs in CNNM4 for both basolateral sorting and interaction with ?1A and ?1B. These results imply that CNNM4 is sorted to the basolateral membrane by the complementary function of AP-1A and AP-1B. PMID:25449265

  13. Method for hot press forming articles

    DOEpatents

    Baker, Robert R.; Hartsock, Dale L.

    1982-01-01

    This disclosure relates to an improved method for achieving the best bond strength and for minimizing distortion and cracking of hot pressed articles. In particular, in a method for hot press forming both an outer facing circumferential surface of and an inner portion of a hub, and of bonding that so-formed outer facing circumferential surface to an inner facing circumferential surface of a pre-formed ring thereby to form an article, the following improvement is made. Normally, in this method, the outside ring is restrained by a restraining sleeve of ring-shaped cross-section having an inside diameter. A die member, used to hot press form the hub, is so-formed as to have an outside diameter sized to engage the inside diameter of the restraining sleeve in a manner permitting relative movement therebetween. The improved method is one in which several pairs of matched restraining sleeve and die member are formed with each matched pair having a predetermined diameter. The predetermined diameter of each matched pair is different from another matched pair by stepped increments. The largest inside diameter of a restraining sleeve is equal to the diameter of the outer facing circumferential surface of the hub. Each pair of the matched restraining sleeve and die member is used to form an article in which an inside hub is bonded to an outside ring. The several samples so-formed are evaluated to determine which sample has the best bond formed between the hub and the ring with the least or no cracking or distortion in the ring portion of the article. Thereafter, the matched restraining sleeve and die member which form the article having the best bonding characteristics and least distortion cracking is then used for repeated formations of articles.

  14. Press Site Auditorium dedicated to John Holliman

    NASA Technical Reports Server (NTRS)

    1999-01-01

    From left, Center Director Roy Bridges and NASA Administrator Daniel S. Goldin applaud as Jay Holliman, with the help of his mother, Mrs. Dianne Holliman, unveils a plaque honoring his father, the late John Holliman. At right is Tom Johnson, news group chairman of CNN. The occasion was the dedication of the KSC Press Site auditorium as the John Holliman Auditorium to honor the CNN national correspondent for his enthusiastic, dedicated coverage of America's space program. The auditorium was built in 1980 and has been the focal point for new coverage of Space Shuttle launches. The ceremony followed the 94th launch of a Space Shuttle, on mission STS-96, earlier this morning.

  15. STS-114: Discovery Post Landing Press Briefing

    NASA Technical Reports Server (NTRS)

    2005-01-01

    Dean Acosta, NASA Public Affairs Deputy Assistant Administrator hosted this press briefing. Michael Griffin, NASA Administrator; Bill Parsons, Shuttle Program Manager; Michael Leinbach, Shuttle Launch Director; and Bill Ready, Space Operations Associate Administrator were present. The Panel specifically honored the Columbia crew as they praised Commander Eileen Collin's performance in bringing the Discovery and crew safe back to Earth. Re-entry, test flight and next test flight, thermal insulation, heat, vehicle inspection, turn around processing, and ferrying Discovery back to the Kennedy Space Center were topics covered with the News media. Michael Griffin announced the launching of Mars Reconnaissance Orbiter will take place the following morning.

  16. Correction magnet power supplies for APS machine

    SciTech Connect

    Kang, Y.G.

    1991-04-01

    A number of correction magnets are required for the advanced photon source (APS) machine to correct the beam. There are five kinds of correction magnets for the storage ring, two for the injector synchrotron, and two for the positron accumulator ring (PAR). Table I shoes a summary of the correction magnet power supplies for the APS machine. For the storage ring, the displacement of the quadrupole magnets due to the low frequency vibration below 25 Hz has the most significant effect on the stability of the positron closed orbit. The primary external source of the low frequency vibration is the ground motion of approximately 20 {mu}m amplitude, with frequency components concentrated below 10 Hz. These low frequency vibrations can be corrected by using the correction magnets, whose field strengths are controlled individually through the feedback loop comprising the beam position monitoring system. The correction field require could be either positive or negative. Thus for all the correction magnets, bipolar power supplies (BPSs) are required to produce both polarities of correction fields. Three different types of BPS are used for all the correction magnets. Type I BPSs cover all the correction magnets for the storage ring, except for the trim dipoles. The maximum output current of the Type I BPS is 140 Adc. A Type II BPS powers a trim dipole, and its maximum output current is 60 Adc. The injector synchrotron and PAR correction magnets are powered form Type III BPSs, whose maximum output current is 25 Adc.

  17. Magnetic fields of the Ap stars

    SciTech Connect

    Borra, E.F.; Landstreet, J.D.

    1980-03-01

    We have conducted a survey of longitudinal magnetic fields (B/sub e/) among bright northern and southern Ap stars. The photoelectric technique used involves circular Zeeman polarimetry in the wings of H..beta... We find that the photoelectric B/sub e/ curves tend to be more harmonic than the photographic B/sub e/ curves. We have discovered magnetic fields in several rapidly rotating Ap stars. There is marginal statistical evidence to suggest that the rapid rotators might have surface magnetic fields smaller than the slow rotators; however, some very rapid rotators (P=0.5 days) can clearly have B/sub e/ extrema (approx.1 kilogauss) comparable to the extrema of slow rotators. We do not find serious evidence for irregular B/sub e/ variations, although we cannot exclude irregular variations of the order of 200 gauss in some stars. The astrophysical implications of our findings are briefly discussed. We have observed several Am and Hg-Mn stars, finding no evidence of magnetic fields.

  18. On the Mechanisms for Defeating AP Projectiles

    NASA Astrophysics Data System (ADS)

    Rosenberg, Z.; Dekel, E.; Ashuach, Y.; Yeshurun, Y.

    The important mechanisms for defeating armor piercing (AP) projectiles are reviewed in this paper. These mechanisms are based on the compressive strength of the target material (its inherent resistance to penetration) and on the asymmetrical forces which it exerts on the threat, through proper geometrical arrangements. We discuss the basic features of the resistance to penetration, starting with the classical analysis of the cavity expansion process in elasto-plastic solids. This property of the target is responsible for the deceleration of hard cored projectiles and for the erosion of long rods, under normal impact conditions. We then discuss the asymmetrical interaction of AP projectiles with inclined plates (metals and polymers) and with ceramic spheres. These asymmetric forces are responsible for their deflection and breakup. Our work combines experimental observations with numerical simulations and engineering models, which enhance the understanding of the various phenomena encountered in these complex situations. This understanding is necessary for optimizing the performance of any armor design against a given threat.

  19. The APS control system network upgrade.

    SciTech Connect

    Sidorowicz, K. v.; Leibfritz, D.; McDowell, W. P.

    1999-10-22

    When it was installed,the Advanced Photon Source (APS) control system network was at the state-of-the-art. Different aspects of the system have been reported at previous meetings [1,2]. As loads on the controls network have increased due to newer and faster workstations and front-end computers, we have found performance of the system declining and have implemented an upgraded network. There have been dramatic advances in networking hardware in the last several years. The upgraded APS controls network replaces the original FDDI backbone and shared Ethernet hubs with redundant gigabit uplinks and fully switched 10/100 Ethernet switches with backplane fabrics in excess of 20 Gbits/s (Gbps). The central collapsed backbone FDDI concentrator has been replaced with a Gigabit Ethernet switch with greater than 30 Gbps backplane fabric. Full redundancy of the system has been maintained. This paper will discuss this upgrade and include performance data and performance comparisons with the original network.

  20. Evaluating EPA’s AP-42 development methodology to convert or rerate current AP-42 datasets

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In August 2013, the U.S. Environmental Protection Agency’s (EPA) published their new methodology for updating the Compilation of Air Pollution Emission Factors (AP-42). The “Recommended Procedures for Development of Emissions Factors and Use of the WebFIRE Database” instructs that the ratings of the...

  1. Press or pulse exposures determine the environmental fate of cerium nanoparticles in stream mesocosms.

    PubMed

    Baker, Leanne F; King, Ryan S; Unrine, Jason M; Castellon, Benjamin T; Lowry, Gregory V; Matson, Cole W

    2016-05-01

    Risk-assessment models indicate that stream ecosystems receiving municipal wastewater effluent may have the greatest potential for exposure to manufactured nanoparticles. The authors determined the fate of cerium oxide (CeO2 ) nanoparticles in outdoor stream mesocosms using 1) 1-time pulse addition of CeO2 nanoparticles, representative of accidental release, and 2) continuous, low-level press addition of CeO2 nanoparticles, representative of exposure via wastewater effluent. The pulse addition led to rapid nanoparticle floc formation, which appeared to preferentially deposit on periphyton in low-energy areas downstream from the location of the input, likely as a result of gravitational sedimentation. Floc formation limited the concentration of suspended nanoparticles in stream water to <5% of target and subsequent downstream movement. In contrast, press addition of nanoparticles led to higher suspended nanoparticle concentrations (77% of target) in stream water, possibly as a result of stabilization of suspended nanoparticles through interaction with dissolved organic carbon. Smaller nanoparticle aggregates appeared to preferentially adsorb to stream surfaces in turbulent sections, where Ce concentrations were highest in the press, likely a result of stochastic encounter with the surface. Streams receiving wastewater effluent containing nanoparticles may lead to exposure of aquatic organisms over a greater spatial extent than a similar amount of nanoparticles from an accidental release. Exposure models must take into account these mechanisms controlling transport and depositional processes. Environ Toxicol Chem 2016;35:1213-1223. © 2015 SETAC. PMID:26576038

  2. Property Variation of Ni-W Electroformed Mold for Micro-Press Molding

    NASA Astrophysics Data System (ADS)

    Yasui, Manabu; Kaneko, Satoru; Takahashi, Masaharu; Ito, Hiroaki; Arai, Masahiro; Hirabayashi, Yasuo; Ozawa, Takeshi; Maeda, Ryutaro

    2013-11-01

    We proposed a simple method to fabricate a Ni-W electroformed mold for glass micro-press molding. For example, borosilicate glass (D263) was molded using the Ni-W electroformed mold. A Ni-W electroformed mold with a fine line was fabricated by photolithography and electroforming technology. Additionally, the Ni-W electroformed mold did not require a release layer. As the result of molding D263 at 883 K, the minimum pitch of the glass pattern was the same as that of the Ni-W electroformed mold. We argue that the crystallization of amorphous Ni-W occurred with the activation energy derived from the heating of micro-press molding. The heating temperature was 833 K. Additionally, the release characteristics of a Ni-W film were improved by increasing the percentage of W. In terms of the thermochemical stability and high content rate of W, we indicated that Ni-W electroformed molds can be used repeatedly for glass micro-press molding.

  3. Switchable aptamers for biosensing and bioseparation of viruses (SwAps-V).

    PubMed

    Wehbe, Mohamed; Labib, Mahmoud; Muharemagic, Darija; Zamay, Anna S; Berezovski, Maxim V

    2015-05-15

    There is a widespread interest in the development of aptamer-based affinity chromatographic methods for purification of biomolecules. Regardless of the many advantages exhibited by aptamers when compared to other recognition elements, the lack of an efficient regeneration technique that can be generalized to all targets has encumbered further integration of aptamers into affinity-based purification methods. Here we offer switchable aptamers (SwAps) that have been developed to solve this problem and move aptamer-based chromatography forward. SwAps are controlled-affinity aptamers, which have been employed here to purify vesicular stomatitis virus (VSV) as a model case, however this technique can be extended to all biologically significant molecules. VSV is one oncolytic virus out of an arsenal of potential candidates shown to provide selective destruction of cancer cells both in vitro and in vivo. These SwAps were developed in the presence of Ca(2+) and Mg(2+) ions where they cannot bind to their target VSV in absence of these cations. Upon addition of EDTA and EGTA, the divalent cations were sequestered from the stabilized aptameric structure causing a conformational change and subsequently release of the virus. Both flow cytometry and electrochemical impedance spectroscopy were employed to estimate the binding affinities between the selected SwAps and VSV and to determine the coefficient of switching (CoS) upon elution. Among fifteen sequenced SwAps, four have exhibited high affinity to VSV and ability to switch upon elution and thus were further integrated into streptavidin-coated magnetic beads for purification of VSV. PMID:25190090

  4. Actes illocutoires et discours de la presse ecrite (Illocutionary Acts and the Press).

    ERIC Educational Resources Information Center

    Duda, Richard

    This study investigates the applicability of the speech act theory to written discourse, specifically that of the press. A survey of Searle's taxonomy leads to the suggestion that the constituent statements of most newspaper articles belong to the class of illocutionary acts he calls "representatives." In consideration of the basic characteristic…

  5. A single β adaptin contributes to AP1 and AP2 complexes and clathrin function in Dictyostelium.

    PubMed

    Sosa, R Thomas; Weber, Michelle M; Wen, Yujia; O'Halloran, Theresa J

    2012-02-01

    The assembly of clathrin-coated vesicles is important for numerous cellular processes, including nutrient uptake and membrane organization. Important contributors to clathrin assembly are four tetrameric assembly proteins, also called adaptor proteins (APs), each of which contains a β subunit. We identified a single β subunit, named β1/2, that contributes to both the AP1 and AP2 complexes of Dictyostelium. Disruption of the gene encoding β1/2 resulted in severe defects in growth, cytokinesis and development. Additionally, cells lacking β1/2 displayed profound osmoregulatory defects including the absence of contractile vacuoles and mislocalization of contractile vacuole markers. The phenotypes of β1/2 null cells were most similar to previously described phenotypes of clathrin and AP1 mutants, supporting a particularly important contribution of AP1 to clathrin pathways in Dictyostelium cells. The absence of β1/2 in cells led to significant reductions in the protein amounts of the medium-sized subunits of the AP1 and AP2 complexes, establishing a role for the β subunit in the stability of the medium subunits. Dictyostelium β1/2 could resemble a common ancestor of the more specialized β1 and β2 subunits of the vertebrate AP complexes. Our results support the essential contribution of a single β subunit to the stability and function of AP1 and AP2 in a simple eukaryote. PMID:22050483

  6. Thermodynamics of Damaged DNA Binding and Catalysis by Human AP Endonuclease 1

    PubMed Central

    Miroshnikova, A. D.; Kuznetsova, A. A.; Kuznetsov, N. A.; Fedorova, O. S.

    2016-01-01

    Apurinic/apyrimidinic (AP) endonucleases play an important role in DNA repair and initiation of AP site elimination. One of the most topical problems in the field of DNA repair is to understand the mechanism of the enzymatic process involving the human enzyme APE1 that provides recognition of AP sites and efficient cleavage of the 5’-phosphodiester bond. In this study, a thermodynamic analysis of the interaction between APE1 and a DNA substrate containing a stable AP site analog lacking the C1’ hydroxyl group (F site) was performed. Based on stopped-flow kinetic data at different temperatures, the steps of DNA binding, catalysis, and DNA product release were characterized. The changes in the standard Gibbs energy, enthalpy, and entropy of sequential specific steps of the repair process were determined. The thermodynamic analysis of the data suggests that the initial step of the DNA substrate binding includes formation of non-specific contacts between the enzyme binding surface and DNA, as well as insertion of the amino acid residues Arg177 and Met270 into the duplex, which results in the removal of “crystalline” water molecules from DNA grooves. The second binding step involves the F site flipping-out process and formation of specific contacts between the enzyme active site and the everted 5’-phosphate-2’-deoxyribose residue. It was shown that non-specific interactions between the binding surfaces of the enzyme and DNA provide the main contribution into the thermodynamic parameters of the DNA product release step. PMID:27099790

  7. Iodine Volatility and pH Control in the AP-600 Reactor

    SciTech Connect

    Beahm, E.C.; Weber, C.F.

    1998-10-01

    Two design-basis accidents for the AP-600 reactor are formulated and evaluate~ in which significant bypass of the principal pH control system occurs. Some iodine released from the reactor primary system is retained in the Incontainment Refaeling Water Storage Tank (IRWST) water, never entering the containment where trisodium phosphate produces a high pH. Some of this iodine is volatilized and is transported into the reactor containment airspace. in the worst case, a small fraction is released to the environment at design-basis leak rate, yielding a total cumulative iodine release at 30 days of 0.0352 mol (0.023% of core iodine inventory) due to the iodine volatilization bypassing the pH control system. No fission product removal in the containment atmosphere (i.e., natural deposition sprays) is considered.

  8. Scholarly literature and the press: scientific impact and social perception of physics computing

    NASA Astrophysics Data System (ADS)

    Pia, M. G.; Basaglia, T.; Bell, Z. W.; Dressendorfer, P. V.

    2014-06-01

    The broad coverage of the search for the Higgs boson in the mainstream media is a relative novelty for high energy physics (HEP) research, whose achievements have traditionally been limited to scholarly literature. This paper illustrates the results of a scientometric analysis of HEP computing in scientific literature, institutional media and the press, and a comparative overview of similar metrics concerning representative particle physics measurements. The picture emerging from these scientometric data documents the relationship between the scientific impact and the social perception of HEP physics research versus that of HEP computing. The results of this analysis suggest that improved communication of the scientific and social role of HEP computing via press releases from the major HEP laboratories would be beneficial to the high energy physics community.

  9. EIA new releases, November--December 1995

    SciTech Connect

    1996-02-09

    Thus publication contains information compiled by the Energy information administration (EIA) on the following topics: heating fuel supplies; alternative fuel vehicles; natural gas production; clean air laws and coal transportation; EIA`s world Wide Web Site; EIA`s CD-ROM; Press Releases; Microfiched products; electronic publishing; new reports; machine-readable files; how to order EIA publications; and Energy Data Information Contracts.

  10. EIA new releases, July--August, 1995

    SciTech Connect

    1995-10-02

    This publication identifies energy related publications of the Energy Information Administration of the US Department of Energy. The topics and articles in this issue include data on residential energy use available on diskettes and Internet, natural gas price predictions, coal deliveries to electric utilities, growth in the US uranium industry, microfiche products, features and press releases, EIA`s electronic publishing system, new reports, machine-readable files, how to order EIA publications and energy data information contacts.

  11. Control units for APS power supplies

    SciTech Connect

    Despe, O.D.; Saunders, C.; McGhee, D.G.

    1993-07-01

    The Advanced Photon Source (APS) accelerator facility is made up of five major subsystems in addition to the linac: the positron accumulator ring (PAR), low energy transport (LET), booster synchrotron (SYNCH), high energy transport (HET), the storage ring (SR). Each subsystem has multiple magnet power supply combinations, some requiring multiple of operation. These magnet and power supply combinations computer controlled and monitored. The power supply control unit (PSCU) is the first layer of hardware and software above the power supply itself and is described in this paper. The description includes the basic philosophy for each of operation and how it influences the topology and of implementing control. The design of the analog reference blocks (ARBs) influenced the design of other custom functions well as the feedback controls for vibration and other dynamic corrections. The command set supported by the PSCU is discussed.

  12. The challenging SED of AP Librae

    NASA Astrophysics Data System (ADS)

    Sanchez, David; Giebels, Berrie; Fortin, Pascal

    2012-08-01

    Matching the broad-band emission of active galaxies with the predictions of theoretical models can be used to derive constraints on the properties of the emitting region and to probe the physical processes involved. AP Librae is the third low frequency peaked BL Lac (LBL) detected at very high energy (VHE, E>100GeV) by an Atmospheric Cherenkov Telescope; most VHE BL Lacs (34 out of 39) belong to the high-frequency and intermediate-frequency BL Lac classes (HBL and IBL). LBL objects tend to have a higher luminosity with lower peak frequencies than HBLs or IBLs. The characterization of their time-averaged spectral energy distribution is challenging for emission models such as synchrotron self-Compton (SSC) models.

  13. Status of the APS Diagnostics Undulator Beamline

    NASA Astrophysics Data System (ADS)

    Yang, B. X.; Lumpkin, A. H.; Goeppner, G. A.; Sharma, S.; Rotela, E.; Sheng, I. C.; Moog, E.

    1997-05-01

    We report the status of the diagnostics undulator beamline for the APS storage ring. The beamline was designed for the characterization of the 7-GeV, low-emittance positron beam at high resolution.(B. Yang and A. H. Lumpkin, ``The Planned Photon Diagnostics Beamlines at the Advanced Photon Source,'' BIW94, AIP Conf. Proc. 333, Oct. 1994.) The special diagnostics undulator has been manufactured by STI Optronics. The device exhibits very low magnetic field errors at closed gap of 10.5 mm: first field integral < 15 g \\cdotcm, and phase error < 1.5^circ for the first harmonic radiation. The front end of the beamline and an in-air monochromator are being installed and tested for use on divergence and directional stability measurements with a target resolution of 3 μrad utilizing the first harmonic radiation of 23 keV. Initial results of these measurements will be presented as available.

  14. Summary of Calcine Disposal Development Using Hot Isostatic Pressing

    SciTech Connect

    Bateman, Ken; Wahlquist, Dennis; Hart, Edward; McCartin, William

    2015-03-01

    Battelle Energy Alliance, LLC, has demonstrated the effectiveness of the hot isostatic press (HIP) process for treatment of hazardous high-level waste known as calcine that is stored at the Idaho Nuclear Technology and Engineering Center (INTEC) at Idaho National Laboratory. HIP trials performed with simulated calcines at Idaho National Laboratory’s Materials and Fuels Complex and an Australian Nuclear Science and Technology Organization facility from 2007 to 2010 produced a dense, monolithic waste form with increased chemical durability and effective (storage) volume reductions of ~10 to ~70% compared to granular calcine forms. In December 2009, the U.S. Department of Energy signed an amended Record of Decision selecting HIP technology as the treatment method for the 4,400 m3 of granular zirconia and alumina calcine stored at INTEC. Testing showed that HIP treatment reduces the risks associated with radioactive and hazardous constituent release, post-production handling, and long-term (repository) storage of calcines and would result in estimated storage cost savings in the billions of dollars. Battelle Energy Alliance has the ability to complete pilot-scale HIP processing of INTEC calcine, which is the next necessary step in implementing HIP processing as a calcine treatment method.

  15. Hot press molding process for pyramid-type glass optical multiplexer

    NASA Astrophysics Data System (ADS)

    Ko, Myeong-Jin; Park, Soon-Sub

    2014-12-01

    By developing a pyramid-shaped reflector, we were able to remove the optical filter that causes the decline in light efficiency in existing systems. A pyramid-type glass optical multiplexer (MUX) can be designed for beam coupling efficiency >60% in a combined module. The module was designed and optimized using CODE V, which utilizes nonlinear curve fitting numerical analysis. Based on optical design data, aspheric grinding paths were developed using ULG APS software. Tungsten carbide optical MUX mold cores were fabricated with an ultraprecision grinding machining device [ULG-100C(H3)] and optimum grinding machining of optical surface roughness (<60 nm, angle tolerance <±0.05 deg). Pyramid-type optical MUX was fabricated using the hot press molding technique, and it was measured by using a contact geometry measuring device for reflection angle and angle uniformity. The measurement data were suitable for 49±0.05 deg, which was the design criterion. In addition, angle uniformity was >99.985%. A pyramid-type glass optical MUX molding technique was developed using an optical mold design, ultraprecision grinding machining technology, and a hot press molding system.

  16. Direct drive digital servo press with high parallel control

    NASA Astrophysics Data System (ADS)

    Murata, Chikara; Yabe, Jun; Endou, Junichi; Hasegawa, Kiyoshi

    2013-12-01

    Direct drive digital servo press has been developed as the university-industry joint research and development since 1998. On the basis of this result, 4-axes direct drive digital servo press has been developed and in the market on April of 2002. This servo press is composed of 1 slide supported by 4 ball screws and each axis has linearscale measuring the position of each axis with high accuracy less than μm order level. Each axis is controlled independently by servo motor and feedback system. This system can keep high level parallelism and high accuracy even with high eccentric load. Furthermore the 'full stroke full power' is obtained by using ball screws. Using these features, new various types of press forming and stamping have been obtained by development and production. The new stamping and forming methods are introduced and 'manufacturing' need strategy of press forming with high added value and also the future direction of press forming are also introduced.

  17. Medium chains of adaptor complexes AP-1 and AP-2 recognize leucine-based sorting signals from the invariant chain.

    PubMed

    Rodionov, D G; Bakke, O

    1998-03-13

    Interactions between tyrosine- and leucine-based sorting signals in the cytoplasmic tails of transmembrane proteins and adaptor complexes AP-1 and AP-2 are believed to be the first step in the formation of clathrin-coated vesicles that deliver these proteins to their destination. Medium chains of AP-1 and AP-2 have been reported to interact with tyrosine-based sorting signals in a number of in vitro assays. In the present study we found that recombinant medium chains could interact with leucine-based sorting signals from the cytoplasmic tail of the invariant chain. Medium chains may therefore be responsible for the proper recognition of both tyrosine and leucine sorting signals by AP-1 and AP-2 complexes. PMID:9497313

  18. Project W-211, initial tank retrieval systems, description of operations for 241-AP-102 and 241-AP-104

    SciTech Connect

    RIECK, C.A.

    1999-02-25

    The primary purpose of the Initial Tank Retrieval Systems (ITRS) is to provide systems for retrieval of radioactive wastes stored in underground double-shell tanks (DSTS) for transfer to alternate storage, evaporation, pretreatment or treatment, while concurrently reducing risks associated with safety watch list and other DSTs. This Description of Operations (DOO) defines the control philosophy for the waste retrieval system for tanks 241-AP-102 (AP-102) and 241-AP-104 (AP-104). This DOO will provide a basis for the detailed design of the Retrieval Control System (RCS) for AP-102 and AP-104 and establishes test criteria for the RCS. The test criteria will be used during qualification testing and acceptance testing to verify operability.

  19. 30. BUILDING NO. 527, DEHYDRATING PRESSES, LOOKING SOUTH. ALUMINUM NARROWGUAGE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    30. BUILDING NO. 527, DEHYDRATING PRESSES, LOOKING SOUTH. ALUMINUM NARROW-GUAGE GONDOLA CAR IN LEFT BACKGROUND BROUGHT MOISTENED GUN COTTON FROM REST HOUSE (BUILDING NO. 320-B) IN CANS. (ONE OF THESE CANS IS ON UNLOADING PLATFORM RUNNING BESIDE PRESSES). CONTENTS OF CANS WERE UNLOADED INTO PRESSES BY HAND. - Picatinny Arsenal, 500 Area, Powder Factory & Power House, State Route 15 near I-80, Dover, Morris County, NJ

  20. STS-114: Discovery Launch Postponement Press Briefing

    NASA Technical Reports Server (NTRS)

    2005-01-01

    This press briefing addresses the problem that occurred prior to the launch of the STS-114. Dean Acosta, Deputy Assistant Administrator of Public Affairs, introduces the panel which consists of Dr. Michael Griffin, NASA Administrator, William Readdy, Associate Administrator for Space Operations, Wayne Hale, Space Shuttle Program Deputy Manager, Steve Poulas, Orbiter Project Manager, Mike Leinbach, NASA Launch Director, and Bill Parsons, Space Shuttle Program Manager. Wayne Hale expresses that a problem occurred with one of the low level sensors in the hydrogen tank and that the cause of the problem must be identified and rectified. Steve Poulos talks about establishing a troubleshooting plan as a part of the scrub effort and Mike Leinbach describes the process of draining the external tank. Wayne Hale answers questions about the sensors and if the Space Shuttle Discovery is safe to fly and Steve Poulos answers questions about the possible suspects for this problem.

  1. Texaco presses projects for gasification process

    SciTech Connect

    Not Available

    1992-07-06

    This paper reports that Texaco Inc. continues to press international ventures for its gasification process. A combine of Italian companies plans an $800 million integrated gasification/combined cycle power plant at a refinery in Sicily that will use Texaco's process to gasify refinery residual to produce electrical power. Other Italian refiners are expected to follow suit with similar projects. Meanwhile, Texaco and Bitor America Corp., have signed a letter of agreement to develop integrated gasification/combined cycle electrical power generation projects. The venture plans to use Texaco's gasification process and Orimulsion, a boiler fuel that is an emulsion of Venezuelan heavy crude, water, and surfactant, as feedstock. Bitor, Boca Raton, Fla., and its parent, Bitumenes Orinoco SA, are units of Venezuela's state oil company Petroleos de Venezuela SA.

  2. Hot Isostatic Pressing of 60-Nitinol

    NASA Technical Reports Server (NTRS)

    Stanford, Malcolm K.

    2015-01-01

    The effects of varying the time, temperature and pressure during consolidation of 60-Nitinol (Nickel Titanium alloy) by hot isostatic pressing (HIP) were examined. Six HIP cycles with a cycle time of either 2 or 20 hours, temperature of 900 or 1000 degrees Centigrade, and a chamber pressure of either 100 or 200 millipascals were used. The cycle representing the shortest cycle time at the highest temperature and pressure (2 hours/1000 degrees Centigrade/200 millipascals) produced material with the highest hardness (720 Vickers Pyramid Number (HV)). A modest increase in average grain size and significant porosity reduction were observed in material subjected to the longest cycle time at the highest temperature, regardless of the pressure applied. The intent of this study is to facilitate the technology transfer involved in the processing of this material.

  3. Metallized solid rocket propellants based on AN/AP and PSAN/AP for access to space

    NASA Astrophysics Data System (ADS)

    Levi, S.; Signoriello, D.; Gabardi, A.; Molinari, M.; Galfetti, L.; Deluca, L. T.; Cianfanelli, S.; Klyakin, G. F.

    2009-09-01

    Solid rocket propellants based on dual mixes of inorganic crystalline oxidizers (ammonium nitrate (AN) and ammonium perchlorate (AP)) with binder and a mixture of micrometric-nanometric aluminum were investigated. Ammonium nitrate is a low-cost oxidizer, producing environment friendly combustion products but with lower specific impulse compared to AP. The better performance obtained with AP and the low quantity of toxic emissions obtained by using AN have suggested an interesting compromise based on a dual mixture of the two oxidizers. To improve the thermal response of raw AN, different types of phase stabilized AN (PSAN) and AN/AP co-crystals were investigated.

  4. The AP2-like gene NsAP2 from water lily is involved in floral organogenesis and plant height.

    PubMed

    Luo, Huolin; Chen, Sumei; Jiang, Jiafu; Teng, Nianjun; Chen, Yu; Chen, Fadi

    2012-07-01

    APETALA2 (AP2) genes are ancient and widely distributed among the seed plants, and play an important role during the plant life cycle, acting as key regulators of many developmental processes. In this study, an AP2 homologue, NsAP2, was characterized from water lily (Nymphaea sp. cv. 'Yellow Prince') and is believed to be rather primitive in the evolution of the angiosperms. In situ RNA hybridization showed that NsAP2 transcript was present in all regions of the floral primordium, but had the highest level in the emerging floral organ primordium. After the differentiation of floral organs, NsAP2 was strongly expressed in sepals and petals, while low levels were found in stamens and carpels. The NsAP2 protein was suggested to be localized in the cell nucleus by onion transient expression experiment. Overexpression of NsAP2 in Arabidopsis led to more petal numbers, and Arabidopsis plants expressing NsAP2 exhibited higher plant height, which may be a result of down-regulated expression of GA2ox2 and GA2ox7. Our results indicated that the NsAP2 protein may function in flower organogenesis in water lily, and it is a promising gene for plant height improvement. PMID:22591856

  5. Genome-Wide Identification of the Target Genes of AP2-O, a Plasmodium AP2-Family Transcription Factor.

    PubMed

    Kaneko, Izumi; Iwanaga, Shiroh; Kato, Tomomi; Kobayashi, Issei; Yuda, Masao

    2015-05-01

    Stage-specific transcription is a fundamental biological process in the life cycle of the Plasmodium parasite. Proteins containing the AP2 DNA-binding domain are responsible for stage-specific transcriptional regulation and belong to the only known family of transcription factors in Plasmodium parasites. Comprehensive identification of their target genes will advance our understanding of the molecular basis of stage-specific transcriptional regulation and stage-specific parasite development. AP2-O is an AP2 family transcription factor that is expressed in the mosquito midgut-invading stage, called the ookinete, and is essential for normal morphogenesis of this stage. In this study, we identified the genome-wide target genes of AP2-O by chromatin immunoprecipitation-sequencing and elucidate how this AP2 family transcription factor contributes to the formation of this motile stage. The analysis revealed that AP2-O binds specifically to the upstream genomic regions of more than 500 genes, suggesting that approximately 10% of the parasite genome is directly regulated by AP2-O. These genes are involved in distinct biological processes such as morphogenesis, locomotion, midgut penetration, protection against mosquito immunity and preparation for subsequent oocyst development. This direct and global regulation by AP2-O provides a model for gene regulation in Plasmodium parasites and may explain how these parasites manage to control their complex life cycle using a small number of sequence-specific AP2 transcription factors. PMID:26018192

  6. Vinpocetine inhibits glutamate release induced by the convulsive agent 4-aminopyridine more potently than several antiepileptic drugs.

    PubMed

    Sitges, M; Sanchez-Tafolla, B M; Chiu, L M; Aldana, B I; Guarneros, A

    2011-10-01

    4-Aminopyridine (4-AP) is a convulsing agent that in vivo preferentially releases Glu, the most important excitatory amino acid neurotransmitter in the brain. Here the ionic dependence of 4-AP-induced Glu release and the effects of several of the most common antiepileptic drugs (AEDs) and of the new potential AED, vinpocetine on 4-AP-induced Glu release were characterized in hippocampus isolated nerve endings pre-loaded with labelled Glu ([3H]Glu). 4-AP-induced [3H]Glu release was composed by a tetrodotoxin (TTX) sensitive and external Ca2+ dependent fraction and a TTX insensitive fraction that was sensitive to the excitatory amino acid transporter inhibitor, TBOA. The AEDs: carbamazepine, phenytoin, lamotrigine and oxcarbazepine at the highest dose tested only reduced [3H]Glu release to 4-AP between 50-60%, and topiramate was ineffective. Vinpocetine at a much lower concentration than the above AEDs, abolished [3H]Glu release to 4-AP. We conclude that the decrease in [3H]Glu release linked to the direct blockade of presynaptic Na+ channels, may importantly contribute to the anticonvulsant actions of all the drugs tested here (except topiramate); and that the significantly greater vinpocetine effect in magnitude and potency on [3H]Glu release when excitability is exacerbated like during seizures, may involve the increase additionally exerted by vinpocetine in some K+ channels permeability. PMID:21737246

  7. A comparative study between spiral-filter press and belt press implemented in a cloudy apple juice production process.

    PubMed

    De Paepe, Domien; Coudijzer, Katleen; Noten, Bart; Valkenborg, Dirk; Servaes, Kelly; De Loose, Marc; Diels, Ludo; Voorspoels, Stefan; Van Droogenbroeck, Bart

    2015-04-15

    In this study, advantages and disadvantages of the innovative, low-oxygen spiral-filter press system were studied in comparison with the belt press, commonly applied in small and medium size enterprises for the production of cloudy apple juice. On the basis of equivalent throughput, a higher juice yield could be achieved with spiral-filter press. Also a more turbid juice with a higher content of suspended solids could be produced. The avoidance of enzymatic browning during juice extraction led to an attractive yellowish juice with an elevated phenolic content. Moreover, it was found that juice produced with spiral-filter press demonstrates a higher retention of phenolic compounds during the downstream processing steps and storage. The results demonstrates the advantage of the use of a spiral-filter press in comparison with belt press in the production of a high quality cloudy apple juice rich in phenolic compounds, without the use of oxidation inhibiting additives. PMID:25466116

  8. Using selenomethionyl derivatives to assign sequence in low-resolution structures of the AP2 clathrin adaptor.

    PubMed

    Kelly, Bernard T; Graham, Stephen C; Owen, David J

    2016-03-01

    Selenomethionine incorporation is a powerful technique for assigning sequence to regions of electron density at low resolution. Genetic introduction of methionine point mutations and the subsequent preparation and crystallization of selenomethionyl derivatives permits unambiguous sequence assignment by enabling the placement of the anomalous scatterers (Se atoms) thus introduced. Here, the use of this approach in the assignment of sequence in a part of the AP2 clathrin adaptor complex that is responsible for clathrin binding is described. AP2 plays a pivotal role in clathrin-mediated endocytosis, a tightly regulated process in which cell-surface transmembrane proteins are internalized from the plasma membrane by incorporation into lipid-enclosed transport vesicles. AP2 binds cargo destined for internalization and recruits clathrin, a large trimeric protein that helps to deform the membrane to produce the transport vesicle. By selenomethionine labelling of point mutants, it was shown that the clathrin-binding site is buried within a deep cleft of the AP2 complex. A membrane-stimulated conformational change in AP2 releases the clathrin-binding site from autoinhibition, thereby linking clathrin recruitment to membrane localization. PMID:26960121

  9. Using selenomethionyl derivatives to assign sequence in low-resolution structures of the AP2 clathrin adaptor

    PubMed Central

    Kelly, Bernard T.; Graham, Stephen C.; Owen, David J.

    2016-01-01

    Selenomethionine incorporation is a powerful technique for assigning sequence to regions of electron density at low resolution. Genetic introduction of methionine point mutations and the subsequent preparation and crystallization of selenomethionyl derivatives permits unambiguous sequence assignment by enabling the placement of the anomalous scatterers (Se atoms) thus introduced. Here, the use of this approach in the assignment of sequence in a part of the AP2 clathrin adaptor complex that is responsible for clathrin binding is described. AP2 plays a pivotal role in clathrin-mediated endocytosis, a tightly regulated process in which cell-surface transmembrane proteins are internalized from the plasma membrane by incorporation into lipid-enclosed transport vesicles. AP2 binds cargo destined for internalization and recruits clathrin, a large trimeric protein that helps to deform the membrane to produce the transport vesicle. By selenomethionine labelling of point mutants, it was shown that the clathrin-binding site is buried within a deep cleft of the AP2 complex. A membrane-stimulated conformational change in AP2 releases the clathrin-binding site from autoinhibition, thereby linking clathrin recruitment to membrane localization. PMID:26960121

  10. Compressive strength, fluoride release and recharge of fluoride-releasing materials.

    PubMed

    Xu, Xiaoming; Burgess, John O

    2003-06-01

    The compressive strength, fluoride releases and recharge profiles of 15 commercial fluoride-releasing restorative materials have been studied. The materials include glass ionomers (Fuji IX, Ketac Molar, Ketac Silver, and Miracle Mix), resin-modified glass ionomers (Fuji II LC Improved, Photac-Fil, and Vitremer), compomers (Compoglass, Dyract AP, F2000, and Hytac) and composite resins (Ariston pHc, Solitaire, Surefil and Tetric Ceram). A negative linear correlation was found between the compressive strength and fluoride release (r(2)=0.7741), i.e., restorative materials with high fluoride release have lower mechanical properties. The fluoride-releasing ability can be partially regenerated or recharged by using a topical fluoride agent. In general, materials with higher initial fluoride release have higher recharge capability (r(2)=0.7088). Five equations have been used in curve fitting to describe the cumulative fluoride release from different materials. The equation [F](c)=[F](I)(1-e(-bt))+betat best describes the cumulative fluoride release for most glass ionomers, resin-modified glass ionomers, and some high fluoride-releasing compomers and composites, whereas [F](c)=[F](I)/(t(1/2)+t)+alphat best describes the cumulative fluoride release for most compomers and composite resins. The clinic applications of different fluoride-releasing materials have also been discussed. PMID:12695072

  11. INTEGRAL Science Data Centre to be presented to the press

    NASA Astrophysics Data System (ADS)

    2002-03-01

    The task of INTEGRAL, the most sensitive gamma-ray observatory ever launched, will be to gather some of the most energetic radiation that comes from space. It will pinpoint and study gamma-ray sources in unprecedented detail and will help to solve some of the biggest mysteries in astronomy: INTEGRAL will investigate the origin of enigmatic gamma-ray bursts, brief but extremely powerful releases of energy, and will bring much new information on stellar explosions and black holes. Not only does INTEGRAL tell us about places where we could not live, it also tell us about the processes that made the Universe habitable, such as the formation of chemical elements. The INTEGRAL Science Data Centre (ISDC), located near Geneva, represents the key element in the exploitation and analysis of the data that will come from INTEGRAL during the two years planned for in-orbit operations. In the centre, the data will be analysed, formatted and made accessible to the worldwide astronomical community. Such fundamental work on INTEGRAL data guarantees that data can be exploited by a wide community of astronomers, including those who are not familiar with the instrumentation used for gamma-ray observations. The ISDC is supported and funded by a dozen institutes in Europe and the United States (the ISDC consortium). The press conference on 11 April marks the end of the centre's development phase and the start of its operational phase. The presence of the ISDC in Switzerland represents a particular opportunity for Swiss scientists, who will participate in a special way to the development of high-energy particle astrophysics, as a result of having privileged access to INTEGRAL data. Speakers at the press conference will include Professor T. Courvoisier (Geneva Observatory, Principal Investigator of the INTEGRAL Science Data Centre), Doctor P. Creola, (Head of Swiss Space Office), and Professor D. Southwood (Director of Science at the European Space Agency). Note to editors INTEGRAL, ESA's International Gamma-Ray Astrophysics Laboratory, will be launched in October 2002 on a Proton rocket from Baikonour, Kazakhstan. The spacecraft is currently subject to final testing at ESA's European Space Research & Technology Centre (ESTEC) in Noordwijk, the Netherlands, while the ground segment facilities - from which INTEGRAL operations will be controlled - are preparing for final review in June. The spacecraft will be shipped to the launch site in August 2002.

  12. An alternatively spliced mRNA from the AP-2 gene encodes a negative regulator of transcriptional activation by AP-2.

    PubMed Central

    Buettner, R; Kannan, P; Imhof, A; Bauer, R; Yim, S O; Glockshuber, R; Van Dyke, M W; Tainsky, M A

    1993-01-01

    AP-2 is a retinoic acid-inducible and developmentally regulated activator of transcription. We have cloned an alternative AP-2 transcript (AP-2B) from the human teratocarcinoma cell line PA-1, which encodes a protein differing in the C terminus from the previously isolated AP-2 protein (AP-2A). This protein contains the activation domain of AP-2 and part of the DNA binding domain but lacks the dimerization domain which is necessary for DNA binding. Analysis of overlapping genomic clones spanning the entire AP-2 gene proves that AP-2A and AP-2B transcripts are alternatively spliced from the same gene. Both transient and stable transfection experiments show that AP-2B inhibits AP-2 transactivator function, as measured by an AP-2-responsive chloramphenicol acetyltransferase reporter plasmid. Furthermore, constitutive AP-2B expression in PA-1 cells causes a retinoic acid-resistant phenotype, anchorage-independent growth in soft agar, and tumorigenicity in nude mice, in a fashion similar to transformation of these cells by oncogenes. To determine the mechanism by which AP-2B exerts its inhibitory function, we purified bacterially expressed AP-2A and AP-2B proteins. While bacterial AP-2B does not bind an AP-2 consensus site, it strongly inhibits binding of the endogenous AP-2 present in PA-1 cell nuclear extracts. However, DNA sequence-specific binding of bacterially expressed AP-2A cannot be inhibited by bacterially expressed AP-2B. Therefore, inhibition of AP-2 activity by the protein AP-2B may require an additional factor or modification supplied by nuclear extracts. Images PMID:8321221

  13. AP-42 ADDITIONS AND REVISIONS - RUBBER PRODUCTS MANUFACTURING

    EPA Science Inventory

    This project develops emission factors, etc., for the rubber products industry which are appended to AP-42. AP42 is a massive collection of material which describes processes which generate air emissions and presents emission factors and control effectiveness information. As res...

  14. Status of the Advanced Photon Source (APS) linear accelerator

    SciTech Connect

    White, M.; Berg, W.; Fuja, R.; Grelick, A.; Mavrogenes, G.; Nassiri, A.; Russell, T.; Wesolowski, W.

    1993-08-01

    A 2856-MHz S-band, 450-MeV electron/positron linear accelerator is the first part of the injector for the Advanced Photon Source (APS) 7-GeV storage ring. Construction of the APS linac is currently nearing completion, and commissioning will begin in July 1993. The linac and its current status are discussed in this paper.

  15. Data-Based Decision Making: The Road to AP Equity

    ERIC Educational Resources Information Center

    Edwards, Kelcey; Duggan, Odette

    2012-01-01

    Presented at the Advanced Placement Annual Conference (APAC) in Lake Buena Vista, FL in July 2012. This presentation reviews concepts central to achieving equitable AP access and success for all willing and academically prepared students. We analyze trends in participation and performance by race/ethnicity from the AP Report to the Nation and…

  16. The APS SASE FEL : modeling and code comparison.

    SciTech Connect

    Biedron, S. G.

    1999-04-20

    A self-amplified spontaneous emission (SASE) free-electron laser (FEL) is under construction at the Advanced Photon Source (APS). Five FEL simulation codes were used in the design phase: GENESIS, GINGER, MEDUSA, RON, and TDA3D. Initial comparisons between each of these independent formulations show good agreement for the parameters of the APS SASE FEL.

  17. Standards and Excellence: Evidence from Advanced Placement (AP) Exams

    ERIC Educational Resources Information Center

    Dee, Thomas S.; Jacob, Brian A.

    2009-01-01

    This study assesses the effects of state exit exams on the student utilization of and performance on Advanced Placement (AP) exams. AP programs have become an increasingly popular way of providing fairly standardized and academically rigorous academic experiences that can prepare high school students for the transition to post-secondary schooling.

  18. A Closer Examination of the Academic Benefits of AP

    ERIC Educational Resources Information Center

    McKillip, Mary E. M.; Rawls, Anita

    2013-01-01

    The authors sought to better understand the relationship between students participating in the Advanced Placement (AP) program and subsequent performance on the Scholastic Aptitude Test (SAT). Focusing on students graduating from U.S. public high schools in 2010, the authors used propensity scores to match junior year AP examinees in 3 subjects to…

  19. Development of a superconducting undulator for the APS

    NASA Astrophysics Data System (ADS)

    Ivanyushenkov, Y.; Abliz, M.; Doose, C.; Fuerst, J.; Hasse, Q.; Kasa, M.; Lev, V.; Mezentsev, N.; Syrovatin, V.; Trakhtenberg, E.; Tsukanov, V.; Vasserman, I.; Gluskin, E.

    2013-03-01

    As the western hemisphere's premier x-ray synchrotron radiation source, the Advanced Photon Source (APS) continues to advance the state of the art in insertion device technology in order to maintain record high brightness, especially in the hard x-ray wavelength region. Due to the unique bunch pattern used for normal APS operations and its ultimate capabilities, the APS has chosen superconducting technology for its future hard x-ray undulator sources. In the last several years, the APS in collaboration with the Budker Institute of Nuclear Physics has being developing the technology for planar, small-period superconducting undulators (SCUs). These developments include the design and construction of several prototypes and the construction of the necessary mechanical, vacuum, and cryogenic infrastructure at the APS site. Several prototypes of the SCU magnetic structure have been built and tested. The first SCU is assembled and will be installed in the APS storage ring at the end of 2012. Expected SCU performance in terms of x-ray brightness should noticeably exceed that of existing APS undulators. Immediately after commissioning, the SCU will be used at APS Sector 6 as the radiation source for high-energy x-ray studies.

  20. AP233: An Information Model for Systems Engineering

    NASA Technical Reports Server (NTRS)

    Siebes, Georg

    2009-01-01

    In today's world, information is abundant. We have no problems generating it. But we are challenged to find, organize, and exchange information. center dot A standardized model of information can help. Such a model nearly completed its development for Systems Engineering. It is referred to as AP233 (AP = Application Protocol).

  1. Notice to fruit growers and nurserymen relative to the naming and release of GulfSnow peach

    Technology Transfer Automated Retrieval System (TEKTRAN)

    GulfSnow peach is jointly released for grower trial by the U.S. Department of Agriculture, Agricultural Research Service (Byron, GA), Georgia Agricultural Experiment Station and Florida Agricultural Experiment Station. GulfSnow was previously tested as AP06-09W and originated from a cross of AP98-3...

  2. High Pressure Reverse Flow APS Engine

    NASA Technical Reports Server (NTRS)

    Senneff, J. M.

    1972-01-01

    A design and test demonstration effort was undertaken to evaluate the concept of the reverse flow engine for the APS engine application. The 1500 lb (6672 N) thrust engine was designed to operate on gaseous hydrogen and gaseous oxygen propellants at a mixture ratio of 4 and to achieve the objective performance of 435 sec (4266 Nsec/kg) specific impulse. Superimposed durability requirements called for a million-cycle capability with 50 hours duration. The program was undertaken as a series of tasks including the initial preliminary design, design of critical test components and finally, the design and demonstration of an altitude engine which could be used interchangeably to examine operating parameters as well as to demonstrate the capability of the concept. The program results are reported with data to indicate that all of the program objectives were met or exceeded within the course of testing on the program. The analysis effort undertaken is also reported in detail and supplemented with test data in some cases where prior definitions could not be made. The results are contained of these analyses as well as the test results conducted throughout the course of the program. Finally, the test data and analytical results were combined to allow recommendations for a flight weight design. This preliminary design effort is also detailed.

  3. Beam instability studies at the APS

    SciTech Connect

    Teng, L.C.

    1994-10-01

    The Argonne Advanced Photon Source, APS (Fig. 1), is a 7-GeV positron storage ring with a circumference of 1104 m. It has a ``third generation, DBA or Chasman-Green`` lattice composed of 40 sectors each having a {approximately}6 m long zero-dispersion straight-section for accommodating insertion devices. Neighboring straight-sections are connected by a 360{degrees}/40 = 9{degrees} double-bend-achromatic bending section designed to produce the smallest emittance attainable with reasonable component parameter values and dynamic apertures. Thus, it is a very strongly focusing lattice with v{sub x} = 35.22 and v{sub y} = 14.30. The beam chamber of the storage ring including all rf, vacuum and photon beam components is designed to ensure that a beam current > 100 mA can be stably stored. We expect that the maximum stable beam current could be as high as 300 mA. This paper will give some details of the studies and computations to ensure the stability of such a beam. The discussions will be organized in the following three parts: Coupled-bunch instability caused by the higher-order modes (HOMs) of the rf cavities; Single-bunch instability due to the resistive wall impedance; and Single-bunch instability due to broadband impedances arising from beam chamber irregularities.

  4. Comparison of ceramic waste forms produced by hot uniaxial pressing and by cold pressing and sintering

    SciTech Connect

    Oversby, V.M.; Vance, E.R.

    1994-09-01

    Synroc C waste form specimens prepared using the Australian-developed technology are uniaxially pressed in stainless steel bellows at 1200{degrees}C and 20MPa. This produces a material with high chemical and physical durability and with the radioactivity enclosed inside both the waste form and the bellows. An alternative method of producing the ceramic product is to use cold pressing of pellets followed by reactive sintering to provide densification and mineralization. Depending on the scale of waste form preparation required and on the activity level and nature of the waste streams, the cold press and sinter method may have advantages. To evaluate the effects of production method on waste form characteristics, especially resistance to dissolution or leaching of waste elements, we have prepared two simulated waste samples for evaluation. Both samples were prepared from liquid precursor materials (alkoxides, nitrates, and colloidal silica) and then doped with waste elements. The precursor material in each case corresponded to a basic phase assemblage of 60% zirconolite, 15% nepheline, 10% spinel, 10% perovskite, and 5% rutile. One sample was doped with 25% by weight of U; the other with 10% by weight each of U and Gd. Each sample was calcined at 750{degrees}C for 1 hr. in a 3.5% H{sub 2} in N{sub 2} atmosphere. Then one portion of each sample was hot pressed at temperatures ranging from 1120 to 1250{degrees}C and 20MPa pressure in steel bellows. A separate portion of each sample was formed into pellets, cold pressed, and sintered in various atmospheres at 1200{degrees}C to produce final products about 2/3 cm in diameter. Samples were then examined to determine density of the product, grain sizes of the phases, phase assemblage, and the location of the U and Gd in the final phases. Density data indicate that sintering gives good results provided that the samples are held at 200{degrees}C for long enough to allow trapped gases to escape.

  5. New Realities for Scholarly Presses in Trying Economic Times

    ERIC Educational Resources Information Center

    Blakesley, David

    2014-01-01

    The author explains that Parlor Press is an independent publisher and distributor of scholarly and trade books in print and digital formats. It was founded in 2002 to address the need for an alternative scholarly, academic press attentive to emergent ideas and forms while maintaining the highest possible standards of quality, credibility, and…

  6. Packaging the News; A Critical Survey of Press, Radio, TV.

    ERIC Educational Resources Information Center

    Aronson, James

    In the 19th century, the American press was characterized by a profusion of independent newspapers, quick to criticize the government. In this century, the press and the other mass media have become owned by relatively few proprietors, all trumpeting the same capitalistic, government line. Even though they criticize the government occasionally,…

  7. Korean and Japanese Press: A Study in Crisis.

    ERIC Educational Resources Information Center

    Ruidl, Richard A.

    During a time of crisis, it is instructive to examine the national press of Japan and Korea, two economic allies that view each other with suspicion. The Japanese press is relatively free and liberal-oriented on the domestic scene but is closely aligned with big business and government with regard to international concerns. The South Korean…

  8. 7. VIEW OF HYDRAULIC HAMMER STAMPING PRESS ON SIDE A ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. VIEW OF HYDRAULIC HAMMER STAMPING PRESS ON SIDE A OF BUILDING 883. THIS TYPE OF PRESS WAS USED FOR BOTH STAINLESS STEEL AND FOR DEPLETED URANIUM. (7/2/86) - Rocky Flats Plant, Uranium Rolling & Forming Operations, Southeast section of plant, southeast quadrant of intersection of Central Avenue & Eighth Street, Golden, Jefferson County, CO

  9. 9. DETAILED VIEW OF BRIQUETTING PRESS HOUSED IN A GLOVE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. DETAILED VIEW OF BRIQUETTING PRESS HOUSED IN A GLOVE BOX. THE PRESS FORMED SCRAP PLUTONIUM METAL FROM FOUNDRY AND FABRICATION PROCESSES INTO SMALL BRIQUETTES. THESE BRIQUETTES BECAME PART OF THE FEED MATERIALS FOR THE FOUNDRY. (5/6/59) - Rocky Flats Plant, Plutonium Fabrication, Central section of Plant, Golden, Jefferson County, CO

  10. 29 CFR 1910.217 - Mechanical power presses.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 5 2010-07-01 2010-07-01 false Mechanical power presses. 1910.217 Section 1910.217 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OCCUPATIONAL SAFETY AND HEALTH STANDARDS Machinery and Machine Guarding § 1910.217 Mechanical power presses. (a) General requirements....

  11. 6. VIEW OF THE BRIQUETTING PRESS AND CHIP CLEANING HOOD. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. VIEW OF THE BRIQUETTING PRESS AND CHIP CLEANING HOOD. SCRAPS OF ENRICHED URANIUM FROM MACHINING OPERATIONS WERE CLEANED IN A SOLVENT BATH, THEN PRESSED INTO BRIQUETTS. THE BRIQUETTS WERE USED AS FEED MATERIAL FOR THE FOUNDRY. (4/4/66) - Rocky Flats Plant, General Manufacturing, Support, Records-Central Computing, Southern portion of Plant, Golden, Jefferson County, CO

  12. 19. REMAINS OF FLYWHEEL OF No. 1 PRESS PUMPING ENGINE. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. REMAINS OF FLYWHEEL OF No. 1 PRESS PUMPING ENGINE. GEARS ON EITHER SIDE OF THE FLYWHEEL WERE TURNED INTERMEDIATE GEARS WHICH POWERED THE PUMPS. - U.S. Steel Homestead Works, Press Shop No. 1, Along Monongahela River, Homestead, Allegheny County, PA

  13. What Members Should Ask of Their Scholastic Press Associations.

    ERIC Educational Resources Information Center

    Konkle, Bruce E.

    1999-01-01

    Discusses 3 major concerns of publication advisers and scholastic press association directors regarding scholastic press associations: technology (technical support, adviser/student training, costs involved in upgrading); promotion of scholastic journalism as a viable school curriculum; and membership offerings (number/type of competitions,…

  14. Massachusetts Adviser Urges a National Student Press Rights Drive.

    ERIC Educational Resources Information Center

    Proudfoot, Harry

    2000-01-01

    Argues that students are being trained to believe that censorship of the press is a good idea. Shows, using two examples dealing with teenage pregnancies and gangs, how students can bring about real change in their school climate through their school newspaper--but only if it is a free press controlled by students, not the administration. (SR)

  15. Rural Press for Village Post-Literacy Literature.

    ERIC Educational Resources Information Center

    Sam-Kpakra, Robert H.; And Others

    Three articles concerning the development of the rural press in Africa as a means of communicating and promoting literacy are included in this collection of reprints. "The Rural Press, Effective Rural Communication Medium" by Robert H. Sam-Kpakra describes this medium of communication by and for people living in areas with little or no access to…

  16. 10. VIEW OF MODULE B, INSTALLATION OF A HYDRAULIC PRESS. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. VIEW OF MODULE B, INSTALLATION OF A HYDRAULIC PRESS. THE PRESS WILL EVENTUALLY BE CONNECTED TO A GLOVE BOX LINE. (9/29/69) - Rocky Flats Plant, Plutonium Manufacturing Facility, North-central section of Plant, just south of Building 776/777, Golden, Jefferson County, CO

  17. 6. Interior, first floor front room. View of pressed metal ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Interior, first floor front room. View of pressed metal ceiling visible through opening in dropped ceiling. (Below the pressed metal ceiling are three wooden joists, two electrical wires and the edges of the dropped ceiling where a panel had been removed). - Ferree Building, 417 Ninth Street, Northwest, Washington, District of Columbia, DC

  18. First Amendment Speech and Press Theory: Preferred Position Postulate Reexamined.

    ERIC Educational Resources Information Center

    Stonecipher, Harry W.

    If the United States Supreme Court is to exercise its historic role as guardian of the fundamental freedoms flowing from the speech and press clauses of the first amendment, it is imperative that those basic freedoms be placed in a preferred position. The preferred position doctrine provides adequate safeguards for both speech and press guarantees…

  19. Multiple Measures in the Study of Press Response.

    ERIC Educational Resources Information Center

    Charlebois, Carol

    1979-01-01

    Surveys measures of press behavior; reports on the testing of J. Galtung and M. Ruge's theory about the structure of news. Concludes that there are three major dimensions to press response to events: the decision to record the event, and considerations regarding space allocation and reader attention. (GT)

  20. Criticism of the Press: Its Social, Psychological and Political Origins.

    ERIC Educational Resources Information Center

    Becker, Lee B.; And Others

    This study examines data from several national polls about press coverage during the Watergate scandal, in order to assess the origins of press criticism. The polls were conducted between 28 September and 6 October 1973, during June 1974, and in August 1974. The data suggest that political variables--particularly support of Nixon, party…

  1. Development of press-coated, floating-pulsatile drug delivery of lisinopril.

    PubMed

    Jagdale, Swati C; Suryawanshi, Vishnu M; Pandya, Sudhir V; Kuchekar, Bhanudas S; Chabukswar, Aniruddha R

    2014-06-01

    Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor, primarily used for the treatment of hypertension, congestive heart failure, and heart attack. It belongs to BCS class III having a half-life of 12 hrs and 25% bioavailability. The purpose of the present work was to develop a press-coated, floating-pulsatile drug delivery system. The core tablet was formulated using the super-disintegrants crosprovidone and croscarmellose sodium. A press-coated tablet (barrier layer) contained the polymer carrageenan, xanthan gum, HPMC K4M, and HPMC K15M. The buoyant layer was optimized with HPMC K100M, sodium bicarbonate, and citric acid. The tablets were evaluated for physical characteristics, floating lag time, swelling index, FTIR, DSC, and in vitro and in vivo behavior. The 5% superdisintgrant showed good results. The FTIR and DSC study predicted no chemical interactions between the drug and excipients. The formulation containing xanthan gum showed drug retaining abilities, but failed to float. The tablet containing HPMC K15M showed a high swelling index. The lag time for the tablet coated with 200 mg carrageenan was 3±0.1 hrs with 99.99±1.5% drug release; with 140 mg HPMC K4M, the lag time was 3±0.1 hrs with 99.71±1.2% drug release; and with 120 mg HPMC K15M, the lag time was 3±0.2 hrs with 99.98±1.7% drug release. The release mechanism of the tablet followed the Korsmeyer-Peppas equation and a first-order release pattern. Floating and lag time behavior have shown good in vitro and in vivo correlations. PMID:24959410

  2. Development of Press-Coated, Floating-Pulsatile Drug Delivery of Lisinopril

    PubMed Central

    Jagdale, Swati C.; Suryawanshi, Vishnu M.; Pandya, Sudhir V.; Kuchekar, Bhanudas S.; Chabukswar, Aniruddha R.

    2014-01-01

    Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor, primarily used for the treatment of hypertension, congestive heart failure, and heart attack. It belongs to BCS class III having a half-life of 12 hrs and 25% bioavailability. The purpose of the present work was to develop a press-coated, floating-pulsatile drug delivery system. The core tablet was formulated using the super-disintegrants crosprovidone and croscarmellose sodium. A press-coated tablet (barrier layer) contained the polymer carrageenan, xanthan gum, HPMC K4M, and HPMC K15M. The buoyant layer was optimized with HPMC K100M, sodium bicarbonate, and citric acid. The tablets were evaluated for physical characteristics, floating lag time, swelling index, FTIR, DSC, and in vitro and in vivo behavior. The 5% superdisintgrant showed good results. The FTIR and DSC study predicted no chemical interactions between the drug and excipients. The formulation containing xanthan gum showed drug retaining abilities, but failed to float. The tablet containing HPMC K15M showed a high swelling index. The lag time for the tablet coated with 200 mg carrageenan was 3±0.1 hrs with 99.99±1.5% drug release; with 140 mg HPMC K4M, the lag time was 3±0.1 hrs with 99.71±1.2% drug release; and with 120 mg HPMC K15M, the lag time was 3±0.2 hrs with 99.98±1.7% drug release. The release mechanism of the tablet followed the Korsmeyer-Peppas equation and a first-order release pattern. Floating and lag time behavior have shown good in vitro and in vivo correlations. PMID:24959410

  3. Parallelization of Rocket Engine Simulator Software (PRESS)

    NASA Technical Reports Server (NTRS)

    Cezzar, Ruknet

    1997-01-01

    Parallelization of Rocket Engine System Software (PRESS) project is part of a collaborative effort with Southern University at Baton Rouge (SUBR), University of West Florida (UWF), and Jackson State University (JSU). The second-year funding, which supports two graduate students enrolled in our new Master's program in Computer Science at Hampton University and the principal investigator, have been obtained for the period from October 19, 1996 through October 18, 1997. The key part of the interim report was new directions for the second year funding. This came about from discussions during Rocket Engine Numeric Simulator (RENS) project meeting in Pensacola on January 17-18, 1997. At that time, a software agreement between Hampton University and NASA Lewis Research Center had already been concluded. That agreement concerns off-NASA-site experimentation with PUMPDES/TURBDES software. Before this agreement, during the first year of the project, another large-scale FORTRAN-based software, Two-Dimensional Kinetics (TDK), was being used for translation to an object-oriented language and parallelization experiments. However, that package proved to be too complex and lacking sufficient documentation for effective translation effort to the object-oriented C + + source code. The focus, this time with better documented and more manageable PUMPDES/TURBDES package, was still on translation to C + + with design improvements. At the RENS Meeting, however, the new impetus for the RENS projects in general, and PRESS in particular, has shifted in two important ways. One was closer alignment with the work on Numerical Propulsion System Simulator (NPSS) through cooperation and collaboration with LERC ACLU organization. The other was to see whether and how NASA's various rocket design software can be run over local and intra nets without any radical efforts for redesign and translation into object-oriented source code. There were also suggestions that the Fortran based code be encapsulated in C + + code thereby facilitating reuse without undue development effort. The details are covered in the aforementioned section of the interim report filed on April 28, 1997.

  4. Modeling of planetesimal compaction by hot pressing

    NASA Astrophysics Data System (ADS)

    Neumann, W.; Breuer, D.; Spohn, T.

    2014-07-01

    Compaction of initially porous material prior to melting is an important process that has influenced the interior structure and the thermal evolution of planetesimals in their early history. On one hand, compaction decreases the porosity resulting in a reduction of the radius. On the other hand, the loss of porosity results in an increase of the thermal conductivity of the material and, thus, in a more efficient cooling. Porosity loss by hot pressing is the most efficient process of compaction in planetesimals and can be described by creep flow, which depends on temperature and stress. Hot pressing has been repeatedly modeled using a simplified approach, for which the porosity is gradually reduced in some fixed temperature interval between ~650 K and 700 K [see e.g. 1--3]. This approach neglects the dependence of compaction on stress. In the present study [see 4], we compare this ''parametrized'' method with a self-consistent calculation of porosity loss via a ''creep-related'' approach. We use our thermal evolution model from previous studies [5] to model compaction of an initially porous ordinary chondritic body and consider four basic packings of spherical dust grains (simple cubic, orthorhombic, rhombohedral, and body-centered cubic). Depending on the grain packing, we calculate the effective stress and the associated porosity change via the thermally activated creep flow. For comparison, compaction is also modeled by simply reducing the initial porosity linearly to zero between 650 and 700 K. Since we are interested in thermal metamorphism and not melting, we only consider bodies that experience a maximum temperature below the solidus temperature of the metal phase. For the creep related approach, the temperature interval in which compaction takes place depends strongly on the size of the planetesimal and is not fixed as assumed in the parametrized approach. Depending on the radius, the initial grain size, the activation energy, the initial porosity, and the specific packing of the dust grains, the temperature interval lies within 600--1200 K. This finding implies that the parametrized approach strongly overestimates compaction and underestimates the maximal temperature. For the cases considered, the post-compaction porous layer retained at the surface, is a factor of 2.5 to 4.5 thicker for the creep-related approach. The difference in the temperature evolution between the two approaches increases with decreasing radius, and the maximal temperature can deviate by about 40 % for small bodies.

  5. Speed-invariant, on-press color quality measurements

    SciTech Connect

    Simpson, M.L.; Bliss, R.F.; McMillan, D.E.; Nodine, R.N.; Goddard, J.S.

    1991-12-03

    Color measurement is an important aspect of quality control for graphic printing press operation. Normally, measurements of color quality are performed by sampling the product off-line, in which case feedback to press operators is not available in a timely manner. On-press measurement of color quality provides timely feedback to the press operators; however, maintaining the accuracy of the measurement in a dynamic setting is not trivial. In this paper, a colorimeter measurement system using commercially available equipment is described for making reliable, on-press color measurements. The system was demonstrated on a web test bed running loops of printed graphic images. Examples of commercially printed graphic material include product labels, packaging, stamps, and wall paper. Resulting color measurements were shown to be highly sensitive to variations in color-content while maintaining invariance to web speeds as high as 500 ft/min. 6 refs.

  6. Alloys by Microwave-Activated Hot Pressing

    NASA Astrophysics Data System (ADS)

    Yang, Fan; Fan, Xi An; Rong, Zhen Zhou; Cai, Xin Zhi; Li, Guang Qiang

    2014-11-01

    The p-type Bi0.4Sb1.6Te3 alloys are prepared using a new method of mechanical alloying followed by microwave-activated hot pressing (MAHP). The effect of sintering temperature on the microstructure and thermoelectric properties of Bi0.4Sb1.6Te3 alloys is investigated. Compared with other sintering techniques, the MAHP process can be used to produce relatively compact bulk materials at lower sintering temperatures owing to its unique sintering mechanism. The grain size of the MAHP specimens increases gradually with the sintering temperature and a partially oriented lamellar structure can be formed in some regions of specimens obtained. The formation of the in situ-generated nano-phase is induced by the arcing effect of the MAHP process, which enhances the phonon scattering effect and decreases the lattice thermal conductivity. A minimum lattice thermal conductivity of 0.41 W/(m·K) and a maximum figure of merit value of 1.04 are obtained at 100°C for the MAHP specimen sintered at 325°C. This technique may also be extended to other functional materials to obtain ultrafine microstructures at low sintering temperatures.

  7. Hot isostatic press waste option study report

    SciTech Connect

    Russell, N.E.; Taylor, D.D.

    1998-02-01

    A Settlement Agreement between the Department of Energy and the State of Idaho mandates that all high-level radioactive waste now stored at the Idaho Chemical Processing Plant be treated so that it is ready to move out of Idaho for disposal by the target date of 2035. This study investigates the immobilization of all Idaho Chemical Processing Plant calcine, including calcined sodium bearing waste, via the process known as hot isostatic press, which produces compact solid waste forms by means of high temperature and pressure (1,050 C and 20,000 psi), as the treatment method for complying with the settlement agreement. The final waste product would be contained in stainless-steel canisters, the same type used at the Savannah River Site for vitrified waste, and stored at the Idaho National Engineering and Environmental Laboratory until a national geological repository becomes available for its disposal. The waste processing period is from 2013 through 2032, and disposal at the High Level Waste repository will probably begin sometime after 2065.

  8. [Gender and health in the daily press].

    PubMed

    Revuelta, Gemma; Alonso, Inma; Tomás, Sonia; Guerrero, Marcela; Rohlfs, Izabella

    2004-05-01

    To have a better understanding on the role of the press in the communication of gender and health issues, the content of the five most spread newspapers in Spain was studied (El País, ABC, El Mundo, La Vanguardia and El Periódico de Catalunya) for five years (1997-2001) and the electronic version of The New York Times of the period 1990-1999. An unequal distribution was observed in the responsibility as for the information related to three aspects: positions of responsibility in the newspapers (out of 71 main posts, 67 were men and 4 women); the authors of the articles on health issues (61.2% men and 38,8% women, among the articles that include the author) and the mentioned information sources (81.43% men and 17.77% women). Among the 120 health issues that were covered during the period of the study, only 20 explicitly mentioned a woman (16.67%). Those subjects that included more frequently explicit references were: ablation, iatrogenics, sterilization, sexual and reproductive health, incontinence, beauty and domestic violence. The analysis of the approach to these subjects helped to identify the stereotypes of gender inequality, in the language as well as in the approach. PMID:15171880

  9. [Work disability in public press professions].

    PubMed

    Akermann, S

    2002-09-01

    In this study more than 1,000 cases of long-term disability among members of the press and media were evaluated. Mental disorders were the main cause of disability in almost every fourth case. In women psychiatric illnesses were even more important. The most common diagnosis was that of a depressive disorder which accounted for more than half of all psychiatric cases. The causes of disability of other insurance systems such as the German social security scheme and the pension and disability plan for the medical profession were compared. Mental illnesses are the leading cause of disability in white collar workers and orthopaedic illnesses, especially disorders of the vertebral column, are the leading cause in blue collar workers, as one might have expected. In females mental disorders are even more common than in men whereas men tend to have more cardiovascular problems than women. In this study also some interesting features regarding disability caused by various illnesses after long-term follow-up were found. This opens unknown perspectives allowing new assessment of diseases and eventually will enable the actuary to price medical diagnoses for disability insurance. PMID:12242775

  10. STS-114: Discovery Post MMT Press Conference

    NASA Technical Reports Server (NTRS)

    2005-01-01

    Bruce Buckingham of NASA Public Affairs hosted this press conference. Wayne Hill, Space Shuttle Deputy Program Manager; John Muratore, Shuttle Systems and Integration Manager; Mike Wetmore, Director for Shuttle Processing were present. Wayne started with a video from Shuttle Logistics Depot showing details of a point sensor box commonly named the black box. Work with the trouble shooting continues on a day to day basis, no definite launching date is set. John reports that they are in a mission support mode all over the country until the sensor problem is solved. Mike reports his team will complete scrub and securing tasks through the next day, restore the facility to its normal mode, and will start to a four day process of getting back to launch once trouble shooting is completed. Tanking test, thermal environment, problem identification, engine cut-off sensor problems, sensors, risk, design reviews, test and analysis, correlation of the problem with Columbia, are some of the topics covered with the News media.

  11. Raising the acceptance of the AP2-line

    SciTech Connect

    Trbojevic, D.

    1989-04-05

    The 120 GeV Main Ring proton beam collides with the target at the end of the AP-1 line and creates antiprotons and other secondary particles. The AP-2 line transfers the negative particles from the target to the Debuncher. To provide a bigger antiproton stack size in the Accumulator, both the Debuncher as well as the AP-2 line acceptance have to be raised. This is a proposal for the improvement of the AP-2 line acceptance. The first part of the memo presents an acceptance examination of the existing AP-2 line by computer simulation, while the second presents a short proposal for aperture corrections. The computer program TURTLE was used to trace antiprotons through the AP-2 line without taking into account other negative charged particles. Betatron functions were obtained from the output of the SYNCH computer program. The SYNCH program was also used to check the dispersion match between the AP-2 line and the Debuncher. 3 refs., 6 figs., 5 tabs.

  12. : The AE9/AP9 Next Generation Radiation Specification Models - Progress Report

    NASA Astrophysics Data System (ADS)

    OBrien, Paul; Johnston, W. Robert; Huston, Stuart; Ginet, Gregory

    2015-04-01

    The AE9/AP9 model has now been released to the global satellite design community. Since the release of version 1.0, we have been focused on documenting the model so that it is suitable for consideration as an international standard. We are also working on incorporating new data sources, such as THEMIS, TACSAT-4, and NASA's Van Allen Probes. Finally, we are scoping out architectural improvements to enable improvements requested by industry: improved stitching between the plasma and radiation models, local time dependence in the plasma model, longitude dependence in the electron radiation model, and solar cycle variation in the low altitude protons. We provide a brief update on the status of the model, plans for the future, and progress on international agreements.

  13. The Watchdog in Nineteenth Century Libel Law: A Common Law Concept of Freedom of the Press.

    ERIC Educational Resources Information Center

    Gleason, Timothy W.

    In press law, the individual right of freedom of the press frequently is linked to a public interest or "watchdog" concept of freedom of the press. This concept suggests that the basis for the constitutional protection of press freedom is the role of the press as an institution serving a collective good, as opposed to the traditional view of…

  14. Development of Emergency Response Guidelines (ERGs) for AP1000

    SciTech Connect

    Yuichi Hayashi; Saiu, Gianfranco; Wright, Richard F.

    2006-07-01

    The AP1000 is two-loop 1100 MWe advanced pressurized water reactor (PWR) that uses passive safety features to enhance plant safety and to provide significant and measurable improvements in plant simplification, reliability, investment protection and plant costs. The AP1000 uses proven technology, which builds on over 30 years of operating PWR experience. The AP1000 final design certification has been approved by the NRC in December, 2005. The Emergency Response Guidelines (ERGs) have been developed for the AP1000. The generic ERGs for the low pressure reference PWR plant were used as the basic documents to develop the AP1000 ERGs. The AP1000 design differences from the reference plant were reviewed and reflected in the process of developing operational steps in each ERG. The AP1000 used PRA in both design and licensing. The provisions of the AP1000 PRA were also reviewed and incorporated into the ERGs Although the AP1000 design does not require operator actions for the first 72 hours after accidents, the operator actions with both safety-related and non-safety-related equipment have an important role to mitigate the consequence of accidents. In the event of a LOCA, the AP1000 safety-related passive core cooling system (PXS) provides sources of core makeup water along with an automatic depressurization system (ADS) consisting of several sets of redundant flow paths which are sequentially opened in stages to reduce the reactor coolant system (RCS) pressure in a controlled manner. The final stage of this system, ADS-4, consists of four large valves that open off the hot legs, reducing the pressure to allow gravity injection from the in-containment refueling water storage tank (IRWST) and eventually the containment sump recirculation. The AP1000 has non-safety-related normal residual heat removal system (RNS) pumps which can be used to provide low pressure pumped injection of cask loading pit and/or IRWST water and recirculation of containment water. These pumps are not required to operate following accidents. However, it is expected that they should be used if available and their operator actions should be incorporated into ERGs to restore safety-related PXS and/or to avoid ADS-4 actuation. Several LOCA and other cases were analyzed, including consideration of such operator actions as RNS injection, to support the development process of the AP1000 ERGs. These cases were modeled using the best-estimate state-of-art RELAP5 code. The analyses results show that RNS injection is effective for a typical small LOCA to avoid ADS-4 actuation. (authors)

  15. AP600 design certification thermal hydraulics testing and analysis

    SciTech Connect

    Hochreiter, L.E.; Piplica, E.J.

    1995-09-01

    Westinghouse Electric Corporation, in conjunction with the Department of Energy and the Electric Power Research Institute, have been developing an advanced light water reactor design; the AP600. The AP600 is a 1940 Mwt, 600Mwe unit which is similar to a Westinghouse two-loop Pressurized Water Reactor. The accumulated knowledge on reactor design to reduce the capital costs, construction time, and the operational and maintenance cost of the unit once it begins to generate electrical power. The AP600 design goal is to maintain an overall cost advantage over fossil generated electrical power.

  16. A new gap separation mechanism for APS insertion devices.

    SciTech Connect

    Trakhtenberg, E. M.; Tcheskidov, V.; Den Hartog, P. K.; Deriy, B.; Erdmann, M.; Makarov, O.; Moog, E. R.

    1999-10-25

    A new gap separation mechanism for use with the standard Advanced Photon Source (APS) 3.3-cm-period undulator magnetic structures has been designed and built and the first system has been installed in the APS storage ring. The system allows a minimum magnetic gap of 10 mm for use with the APS 8-mm insertion device vacuum chambers. The mechanism is a bolted steel frame structure with a simple 4-motor mechanical drive train. The control system uses servomotors with incremental rotary encoders and virtual absolute linear encoders.

  17. Mechanism of interaction between human 8-oxoguanine-DNA glycosylase and AP endonuclease.

    PubMed

    Sidorenko, Victoria S; Nevinsky, Georgy A; Zharkov, Dmitry O

    2007-03-01

    Human 8-oxoguanine-DNA glycosylase (OGG1) is the main human base excision protein that removes a mutagenic lesion 8-oxoguanine (8-oxoG) from DNA. Since OGG1 has DNA glycosylase and weak abasic site (AP) lyase activities and is characterized by slow product release, turnover of the enzyme acting alone is low. Recently it was shown that human AP endonuclease (APE1) enhances the activity of OGG1. This enhancement was proposed to be passive, resulting from APE1 binding to or cleavage of AP sites after OGG1 dissociation. Here we present evidence that APE1 could actively displace OGG1 from its product, directly increasing the turnover of OGG1. We have observed that APE1 forms an electrophoretically detectable complex with OGG1 cross-linked to DNA by sodium borohydride. Using oligonucleotide substrates with a single 8-oxoG residue located in their 5'-terminal, central or 3'-terminal part, we have demonstrated that OGG1 activity does not increase only for the first of these three substrates, indicating that APE1 interacts with the DNA stretch 5' to the bound OGG1 molecule. In kinetic experiments, APE1 enhanced the product release constant but not the rate constant of base excision by OGG1. Moreover, OGG1 bound to a tetrahydrofuran analog of an abasic site stimulated the activity of APE1 on this substrate. Using a concatemeric DNA substrate, we have shown that APE1 likely displaces OGG1 in a processive mode, with OGG1 remaining on DNA but sliding away in search for a new lesion. Altogether, our data support a model in which APE1 specifically recognizes an OGG1/DNA complex, distorts a stretch of DNA 5' to the OGG1 molecule, and actively displaces the glycosylase from the lesion. PMID:17126083

  18. Zinc coated sheet steel for press hardening

    NASA Astrophysics Data System (ADS)

    Ghanbari, Zahra N.

    Galvanized steels are of interest to enhance corrosion resistance of press-hardened steels, but concerns related to liquid metal embrittlement have been raised. The objective of this study was to assess the soak time and temperature conditions relevant to the hot-stamping process during which Zn penetration did or did not occur in galvanized 22MnB5 press-hardening steel. A GleebleRTM 3500 was used to heat treat samples using hold times and temperatures similar to those used in industrial hot-stamping. Deformation at both elevated temperature and room temperature were conducted to assess the coating and substrate behavior related to forming (at high temperature) and service (at room temperature). The extent of alloying between the coating and substrate was assessed on undeformed samples heat treated under similar conditions to the deformed samples. The coating transitioned from an α + Gamma1 composition to an α (bcc Fe-Zn) phase with increased soak time. This transition likely corresponded to a decrease in availability of Zn-rich liquid in the coating during elevated temperature deformation. Penetration of Zn into the substrate sheet in the undeformed condition was not observed for any of the processing conditions examined. The number and depth of cracks in the coating and substrate steel was also measured in the hot-ductility samples. The number of cracks appeared to increase, while the depth of cracks appeared to decrease, with increasing soak time and increasing soak temperature. The crack depth appeared to be minimized in the sample soaked at the highest soak temperature (900 °C) for intermediate and extended soak times (300 s or 600 s). Zn penetration into the substrate steel was observed in the hot-ductility samples soaked at each hold temperature for the shortest soak time (10 s) before being deformed at elevated temperature. Reduction of area and elongation measurements showed that the coated sample soaked at the highest temperature and longest soak time maintained the highest ductility when compared to the uncoated sample processed under the sample conditions. Fractography of the hot-ductility samples showed features associated with increased ductility with increased soak time for all soak temperatures. Heat treatments (without elevated temperature deformation) and subsequent room temperature deformation were conducted to investigate the "in-service" behavior of 22MnB5. The uncoated and coated specimens deformed at room temperature showed similar ultimate tensile strength and ductility values. The only notable differences in the room temperature mechanical behavior of uncoated and coated samples processed under the same conditions were a result of differences in the substrate microstructure. All samples appeared to have ductile fracture features; features characteristic of liquid metal embrittlement were not observed.

  19. Influence of Pressing Parameters on the Microstructure of PBX 9501

    NASA Astrophysics Data System (ADS)

    Peterson, P. D.; Mang, J. T.; Fletcher, M. A.; Olinger, B. W.; Roemer, E. L.

    2004-07-01

    Microstructural features, such as defects, crystal morphology, and crystal size distribution can dramatically affect the ignition sensitivity, performance, and mechanical properties of energetic materials. While these features can be characterized for the raw material, little is known about how they are altered during pressing. For example, in the preparation of a consolidated charge of PBX 9501, variables such as ultimate pressure, number of pressing cycles, dwell time, or rest time are varied in order to achieve nominal density of 1.830 g/cc. Although this density is met, differences in pressing parameters can lead to variations in microstructure between samples. To evaluate the effect of pressing parameters on the microstructure, three cylinders of PBX 9501 have been pressed at 5 kpsi, 15 kpsi, and 30 kpsi, using a 100 Ton heated steel die press. Polarized light microscopy (PLM) images taken at 144 locations within each cylinder show differences in porosity, crystal size and size distribution between cylinders and at different locations within the same cylinder. Scanning electron microscopy (SEM) further verifies increased fracture and rubblization of HMX during pressing.

  20. A superconducting solenoid and press for permanent magnet fabrication.

    SciTech Connect

    Mulcahy, T. M.; Hull, J. R.

    2002-07-16

    For the first time, a superconducting solenoid (SCM) was used to increase the remnant magnetization of sintered NdFeB permanent magnets (PMs). In particular, improved magnetic alignment of commercial-grade PM powder was achieved, as it was axial die pressed into 12.7-mm diameter cylindrical compacts in the 76.2-mm warm bore of a 9-T SCM. The press used to compact the powder is unique and was specifically designed for use with the SCM. Although the press was operated in the batch mode for this proof of concept study, its design is intended to enable automated production. In operation, a simple die and punch set made of nonmagnetic materials was filled with powder and loaded into a nonmagnetic press tube. The cantilevered press tube was inserted horizontally, on a carrier manually advanced along a track, into the SCM. The robustness of the mechanical components and the SCM, in its liquid helium dewar, were specifically designed to allow for insertion and extraction of the magnetic powder and compacts, while operating at 9 T. Compaction was achieved by pressing the punches between the closed end of the press tube and the hydraulic cylinder mounted on the opposite end. Improvements up to 10% in magnetization and 20% in energy products of the permanent magnets were obtained, as the alignment fields were increased above the 2-T maximum field of the electromagnets used in industry. Increases in magnetization of 3% are significant in the mature sintered magnet industry.

  1. EPICS Input/Output Controller (IOC) application developer`s guide. APS Release 3.12

    SciTech Connect

    Kraimer, M.R.

    1994-11-01

    This document describes the core software that resides in an Input/Output Controller (IOC), one of the major components of EPICS. The basic components are: (OPI) Operator Interface; this is a UNIX based workstation which can run various EPICS tools; (IOC) Input/Output Controller; this is a VME/VXI based chassis containing a Motorola 68xxx processor, various I/O modules, and VME modules that provide access to other I/O buses such as GPIB, (LAN), Local Area Network; and this is the communication network which allows the IOCs and OPIs to communicate. Epics provides a software component, Channel Access, which provides network transparent communication between a Channel Access client and an arbitrary number of Channel Access servers.

  2. A Key Telegram and a Key Press Release on the Recognition of the State of Israel

    ERIC Educational Resources Information Center

    Byers, CeCe; Alexander, Mary

    1978-01-01

    Reviews the course of events leading to the founding of Israel in 1947. Presents primary source materials, activities, and discussion questions to help students analyze reasons for the Arab-Israeli conflict. (Author/DB)

  3. Remarks by the President at the National Governors Association Education Summit. White House Press Release.

    ERIC Educational Resources Information Center

    Executive Office of the President, Washington, DC.

    In this speech, President Clinton asserts that educational enterprise is now more important than ever and that a candid assessment of it is needed. The American educational system faces unique challenges--a more diverse student population in terms of income, race, ethnicity, and background; fractured authority and financing; schools burdened by…

  4. 57. ORIGINAL TILE PRESS AND EXPERIMENTAL DENTAL KILN, SECOND FLOOR, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    57. ORIGINAL TILE PRESS AND EXPERIMENTAL DENTAL KILN, SECOND FLOOR, NORTH WING, HENRY MERCER USED THE KILN FOR HIS EARLIEST GLAZE TESTS. THE PRESS WAS DESIGNED TO BE USED WITH METAL CASED MOLDS. SINCE ONLY THE EARLIEST TILE DESIGNS ARE IN METAL CASES. THIS TECHNIQUE WAS PROBABLY DISCONTINUED. THIS PRESS WAS, THEREFORE, PROBABLY NOT USED EXTENSIVELY AT THIS SITE. THE UPPER PART OF GLAZE KILN No. 2 IS AT THE LEFT REAR. - Moravian Pottery & Tile Works, Southwest side of State Route 313 (Swamp Road), Northwest of East Court Street, Doylestown, Bucks County, PA

  5. Engaging Cuban Physicists Through the APS/CPS Partnership

    NASA Astrophysics Data System (ADS)

    Lerch, Irving A.; Lerch, Irving A.

    In his reflections on Cuban physics, Marcelo Alonso urges APS to take steps to promote interactions between Cuban and US physicists. As an introduction to Marcello's essay, this note will summarize past and current activities.

  6. A hot-spare injector for the APS linac.

    SciTech Connect

    Lewellen, J. W.

    1999-04-13

    Last year a second-generation SSRL-type thermionic cathode rf gun was installed in the Advanced Photon Source (APS) linac. This gun (referred to as ''gun2'') has been successfully commissioned and now serves as the main injector for the APS linac, essentially replacing the Koontz-type DC gun. To help ensure injector availability, particularly with the advent of top-up mode operation at the APS, a second thermionic-cathode rf gun will be installed in the APS linac to act as a hot-spare beam source. The hot-spare installation includes several unique design features, including a deep-orbit Panofsky-style alpha magnet. Details of the hot-spare beamline design and projected performance are presented, along with some plans for future performance upgrades.

  7. QCD on the Massively Parallel Computer AP1000

    NASA Astrophysics Data System (ADS)

    Akemi, K.; Fujisaki, M.; Okuda, M.; Tago, Y.; Hashimoto, T.; Hioki, S.; Miyamura, O.; Takaishi, T.; Nakamura, A.; de Forcrand, Ph.; Hege, C.; Stamatescu, I. O.

    We present the QCD-TARO program of calculations which uses the parallel computer AP1000 of Fujitsu. We discuss the results on scaling, correlation times and hadronic spectrum, some aspects of the implementation and the future prospects.

  8. 45-Day safety screening report for grab samples from Tank 241-AP-107

    SciTech Connect

    Miller, G.L.

    1995-03-08

    Three samples; 107-AP-1C, 107-AP-2c and 107-AP-3C; were received at 222-S Laboratory for analysis of DSC, TGA and visual appearance. Four additional samples; 107-AP-1D, 107-AP-2D, 107-AP-3D and 107-AP-6; were received for visual appearance only. No results exceeded the safety screen notification criteria. This report compiles the analytical results. Tank 241-AP-107 is a double-shell tank which is not on any of the four Watch Lists.

  9. Thermal Decomposition Characteristics of Orthorhombic Ammonium Perchlorate (o-AP)

    SciTech Connect

    Behrens, R.; Minier, L.

    1999-03-01

    Preliminary STMBMS and SEM results of the thermal decomposition of AP in the orthorhombic phase are presented. The overall decomposition is shown to be complex and controlled by both physical and chemical processes. The data show that the physical and chemical processes can be probed and characterized utilizing SEM and STMBMS. The overall decomposition is characterized by three distinguishing features: an induction period, and accelerator period and a deceleratory period. The major decomposition event occurs in the subsurface of the AP particles and propagates towards the center of the particle with time. The amount of total decomposition is dependent upon particle size and increases from 23% for {approximately}50{micro}m-diameter AP to 33% for {approximately}200{micro}m-diameter AP. A conceptual model of the physical processes is presented. Insight into the chemical processes is provided by the gas formation rates that are measured for the gaseous products. To our knowledge, this is the first presentation of data showing that the chemical and physical decomposition processes can be identified from one another, probed and characterized at the level that is required to better understand the thermal decomposition behavior of AP. Future work is planned with the goal of obtaining data that can be used to develop a mathematical description for the thermal decomposition of o-AP.

  10. 37. Drill press in foreground is one of few machine ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    37. Drill press in foreground is one of few machine tools in operating condition which is still operated occasionally for public demonstrations. - Thomas A. Edison Laboratories, Building No. 5, West Orange, Essex County, NJ

  11. INTERIOR VIEW WITH CARLTON RADIAL ARM DRILL PRESS (THE CARLTON ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    INTERIOR VIEW WITH CARLTON RADIAL ARM DRILL PRESS (THE CARLTON MACHINE TOOL CO., CINCINNATI, OHIO) WITH MACHINE OPERATOR, EDDIE BURTTRAM. - O'Neal Steel, Incorporated, Fabrication Shop, 744 Forty-first Avenue North, Birmingham, Jefferson County, AL

  12. Cars & Censorship: How Advertising Pressure Can Corrupt a Free Press.

    ERIC Educational Resources Information Center

    Collins, Ronald K. L.

    1992-01-01

    Discusses "private censorship" as it relates to car dealers and television advertising. Defines "private censorship" as that which occurs when a broadcaster suppresses or alters a news story that affects commercial clients (advertisers). Makes recommendations for a freer press. (JOW)

  13. A parametric pressing study using a plastic-bonded explosive

    SciTech Connect

    Hayden, D. J.; Maez, L. R.; Olinger, B. W.; Powell, S. J.

    2002-01-01

    Pressed plastic-bonded explosives, PBXs, are commonly used by defense and private industry. PBX 9501 is composed of HMX crystals held together with a plastic binder 'softened' with plasticizers. The detonation behavior of any explosive is very dependent upon its density, with the desire to have a uniform, high density throughout the explosive component. A parametric study has been performed pressing PBX 9501 hydrostatically and uniaxially. The effects of several pressing parameters on the bulk density and density profile, as well as mechanical properties, have been measured. The parameters investigated include pressure, temperature, number of cycles, dwell time, rest time, sack thickness, and particle distribution and size. Density distributions within the pressed explosives were also compared.

  14. 5. FOURTH FLOOR, HOTEL SOAP LINES TO NORTHWEST: PRESS (LEFT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. FOURTH FLOOR, HOTEL SOAP LINES TO NORTHWEST: PRESS (LEFT CENTER), MANUAL CUTTERS (CENTER, RIGHT CENTER) - Colgate & Company Jersey City Plant, Building No. B-15, 90-96 Greene Street, Jersey City, Hudson County, NJ

  15. Consolidation of Si3N4 by hot isostatic pressing

    NASA Technical Reports Server (NTRS)

    Yeh, H. C.; Sikora, P. F.

    1979-01-01

    Silicon nitride (Si3N4) is being considered for gas turbine engine applications because present-day metallic alloys are rapidly approaching the limits of their temperature capabilities. The present investigation was undertaken to determine the feasibility of producing a sound, dense Si3N4 body without additives, using conventional gas hot-isostatic-pressing techniques and an uncommon hydraulic hot-isostatic-pressing technique. These two hot-isostatic-pressing (HIP) techniques produce much higher pressure (275-413 MN/sq m) than conventional hot-pressing techniques and have the potential of producing large bodies of desirable shapes. Evaluation was based on density measurement, microscopic examination, both optical and electron, and X-ray diffraction analysis.

  16. Poland's Press and Broadcasting Under the Gierek Regime

    ERIC Educational Resources Information Center

    Shanor, Donald R.

    1974-01-01

    Reports that the Polish press and broadcasting have been carrying more news and less propaganda since the 1970 Baltic upheavel and that the Polish media are generally allowed more freedom than media in other Communist nations. (RB)

  17. Differential Suppression by Punishment of Nonconsummatory Licking and Lever Pressing

    ERIC Educational Resources Information Center

    Walters, Gary C.; Herring, Barbara

    1978-01-01

    Five experiments investigated the differential effects of shock punishment on nonconsummatory licking (dry licking) and lever pressing. Results support a motivationally based theory of punishment involving the role of incentive stimuli associated with the particular responses studied. (Editor/RK)

  18. Rugged pressed disk electrode has low contact potential

    NASA Technical Reports Server (NTRS)

    Day, J. L.; Mosier, B.

    1965-01-01

    Pressed-disk electrode with low contact potential monitors physiological processes. It consists of silver and silver chloride combined with bentonitic clay. The clay affords a surface that permits use over extended periods without contact deterioration.

  19. VIEW OF INTERIOR SPACE WITH HUFFORD BULLDOZIER FORMING PRESS IN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF INTERIOR SPACE WITH HUFFORD BULLDOZIER FORMING PRESS IN FOREGROUND, FACING NORTHWEST. - Douglas Aircraft Company Long Beach Plant, Aircraft Parts Shipping & Receiving Building, 3855 Lakewood Boulevard, Long Beach, Los Angeles County, CA

  20. VIEW OF INTERIOR SPACE WITH RECTANGULAR SHAPE STRETCH PRESS CONTAINMENT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF INTERIOR SPACE WITH RECTANGULAR SHAPE STRETCH PRESS CONTAINMENT PIT IN BACKGROUND, FACING NORTH. - Douglas Aircraft Company Long Beach Plant, Aircraft Parts Shipping & Receiving Building, 3855 Lakewood Boulevard, Long Beach, Los Angeles County, CA

  1. VIEW OF INTERIOR SPACE WITH SQUARE SHAPE STRETCH PRESS CONTAINMENT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF INTERIOR SPACE WITH SQUARE SHAPE STRETCH PRESS CONTAINMENT PITS CENTER, FACING NORTH. - Douglas Aircraft Company Long Beach Plant, Aircraft Parts Shipping & Receiving Building, 3855 Lakewood Boulevard, Long Beach, Los Angeles County, CA

  2. 2ND FLOOR HALLWAY LOOKING EAST, NOTE PRESSED TIN CEILING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2ND FLOOR HALLWAY LOOKING EAST, NOTE PRESSED TIN CEILING - New York State Soldiers & Sailors Home, Building No. 29, Department of Veterans Affairs Medical Center, 76 Veterans Avenue, Bath, Steuben County, NY

  3. AUTOMOTIVE REPAIR SHOP, DETAIL OF FABRICATING PRESS IN EAST END ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    AUTOMOTIVE REPAIR SHOP, DETAIL OF FABRICATING PRESS IN EAST END OF MAIN WING, WITH SCALE. - Cedar City Automotive Repair Shop, Automotive Repair Shop, 820 North Main Street, Cedar City, Iron County, UT

  4. Grain refinement of aluminum using equal-channel angular pressing

    SciTech Connect

    Horita, Z.; Furukawa, M.; Nemoto, M.; Langdon, T.G.

    2000-07-01

    Using the technique of equal-channel angular (ECA) pressing, it is possible to reduce the grain size of polycrystalline materials to the submicrometer level. Thus, this processing technique has the potential for producing materials which may exhibit superplasticity. This paper describes various factors affecting the development and evolution of the microstructure produced by ECA pressing. Optimization of such factors is then presented for the advent of superplasticity.

  5. Gemini 10 prime crew during post flight press conference

    NASA Technical Reports Server (NTRS)

    1966-01-01

    At podium during Gemini 10 press conference are (l-r) Dr. Robert C. Seamans, Astronauts John Young and Michael Collins and Dr. Robert R. Gilruth (39895); Wide angle view of the Manned Spacecraft Center (MSC) News Center during the Gemini 10 prime crew post flight press conference (38786); Astronaut Young draws diagram on chalk board of tethered extravehicular activity accomplished during Gemini 10 flight (39897).

  6. Low-loss binder for hot pressing boron nitride

    DOEpatents

    Maya, Leon

    1991-01-01

    Borazine derivatives used as low-loss binders and precursors for making ceramic boron nitride structures. The derivative forms the same composition as the boron nitride starting material, thereby filling the voids with the same boron nitride material upon forming and hot pressing. The derivatives have a further advantage of being low in carbon thus resulting in less volatile byproduct that can result in bubble formation during pressing.

  7. Low-loss binder for hot pressing boron nitride

    SciTech Connect

    Maya, L.

    1991-04-23

    Borazine derivatives used as low-loss binders and precursors for making ceramic boron nitride structures are disclosed. The derivative forms the same composition as the boron nitride starting material, thereby filling the voids with the same boron nitride material upon forming and hot pressing. The derivatives have a further advantage of being low in carbon thus resulting in less volatile byproduct that can result in bubble formation during pressing. No Drawings

  8. VIEW OF THE INSTALLATION OF AN EXTRUSION PRESS IN THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF THE INSTALLATION OF AN EXTRUSION PRESS IN THE HIGH BAY AREA OF BUILDING 865. THE EXTRUSION PRESS WAS USED TO PRODUCE CYLINDRICAL BARS, HOLLOW TUBES, AND SHAPES WITH IRREGULAR CROSS-SECTIONS BY FORCING PREHEATED METAL THROUGH A DIE ORIFICE UNDER HIGH PRESSURE. (5/22/70) - Rocky Flats Plant, Metal Research & Development Laboratory, South of Central Avenue at south end of terminus of Ninth Avenue, Golden, Jefferson County, CO

  9. Bending strength studies on hot-pressed silicon carbide

    NASA Technical Reports Server (NTRS)

    Kriegesmann, J.

    1984-01-01

    The 4-point bending strength of 4 grades of hot-pressed SiC was determined at different temperatures. With a transgranular mode of fracture the values for bending strength are retained up to high temperatures. For intergranular fracture the decrease of strength is governed by subcritical crack growth. The intergranular fracture is caused by a high content of silicate glassy phase at the grain boundaries of hot-pressed SiC.

  10. An AP4B1 frameshift mutation in siblings with intellectual disability and spastic tetraplegia further delineates the AP-4 deficiency syndrome.

    PubMed

    Abdollahpour, Hengameh; Alawi, Malik; Kortüm, Fanny; Beckstette, Michael; Seemanova, Eva; Komárek, Vladimír; Rosenberger, Georg; Kutsche, Kerstin

    2015-02-01

    The recently proposed adaptor protein 4 (AP-4) deficiency syndrome comprises a group of congenital neurological disorders characterized by severe intellectual disability (ID), delayed or absent speech, hereditary spastic paraplegia, and growth retardation. AP-4 is a heterotetrameric protein complex with important functions in vesicle trafficking. Mutations in genes affecting different subunits of AP-4, including AP4B1, AP4E1, AP4S1, and AP4M1, have been reported in patients with the AP-4 deficiency phenotype. We describe two siblings from a non-consanguineous couple who presented with severe ID, absent speech, microcephaly, growth retardation, and progressive spastic tetraplegia. Whole-exome sequencing in the two patients identified the novel homozygous 2-bp deletion c.1160_1161delCA (p.(Thr387Argfs*30)) in AP4B1. Sanger sequencing confirmed the mutation in the siblings and revealed it in the heterozygous state in both parents. The AP4B1-associated phenotype has previously been assigned to spastic paraplegia-47. Identification of a novel AP4B1 alteration in two patients with clinical manifestations highly similar to other individuals with mutations affecting one of the four AP-4 subunits further supports the observation that loss of AP-4 assembly or functionality underlies the common clinical features in these patients and underscores the existence of the clinically recognizable AP-4 deficiency syndrome. PMID:24781758

  11. An AP4B1 frameshift mutation in siblings with intellectual disability and spastic tetraplegia further delineates the AP-4 deficiency syndrome

    PubMed Central

    Abdollahpour, Hengameh; Alawi, Malik; Kortm, Fanny; Beckstette, Michael; Seemanova, Eva; Komrek, Vladimr; Rosenberger, Georg; Kutsche, Kerstin

    2015-01-01

    The recently proposed adaptor protein 4 (AP-4) deficiency syndrome comprises a group of congenital neurological disorders characterized by severe intellectual disability (ID), delayed or absent speech, hereditary spastic paraplegia, and growth retardation. AP-4 is a heterotetrameric protein complex with important functions in vesicle trafficking. Mutations in genes affecting different subunits of AP-4, including AP4B1, AP4E1, AP4S1, and AP4M1, have been reported in patients with the AP-4 deficiency phenotype. We describe two siblings from a non-consanguineous couple who presented with severe ID, absent speech, microcephaly, growth retardation, and progressive spastic tetraplegia. Whole-exome sequencing in the two patients identified the novel homozygous 2-bp deletion c.1160_1161delCA (p.(Thr387Argfs*30)) in AP4B1. Sanger sequencing confirmed the mutation in the siblings and revealed it in the heterozygous state in both parents. The AP4B1-associated phenotype has previously been assigned to spastic paraplegia-47. Identification of a novel AP4B1 alteration in two patients with clinical manifestations highly similar to other individuals with mutations affecting one of the four AP-4 subunits further supports the observation that loss of AP-4 assembly or functionality underlies the common clinical features in these patients and underscores the existence of the clinically recognizable AP-4 deficiency syndrome. PMID:24781758

  12. ESA `Huygens and Mars Express' science highlights - call to press

    NASA Astrophysics Data System (ADS)

    2005-11-01

    Almost one year has passed since ESAs Huygens probe landed on Saturns largest moon, Titan. Today, a set of new wide-ranging results from the probes two-and-a-half hour descent and landing, part of the extraordinary NASA/ESA/ASI Cassini-Huygens mission to Saturn and its moons, is ready for release. At the same time, ESAs Mars Express mission is continuing its investigations of Mars, painting a new picture of the 'red planet'. This includes the first ever probing below the surface of Mars, new geological clues with implications for the climate, newly-discovered surface and atmospheric features and, above all, traces of the presence of water on this world. These and other exciting findings from just one year of observations and data analysis - in the context of ESAs overall scientific achievements - will be the focus of a press conference to be held at ESA Headquarters in Paris at 16:00 on 30 November 2005. Media interested in attending are invited to complete the following registration form. Press conference programme Space Science Highlights 2005 From Huygens to Mars Express 30 November 2005, 16:00 hrs Room 137, European Space Agency Headquarters 8-10 Rue Mario-Nikis, F-75738 Paris Cedex, France 15:30 - Registration 16:00 - A Year of European Space Science Successes Prof. David Southwood, ESA Director of Science Programme 16:10 - Highlights of the Huygens Mission Results Jean-Pierre Lebreton, ESA Huygens Project Scientist 16:15 - Robin Duttaroy, Co-Investigator, Doppler Wind Experiment, University of Bonn, Germany 16:20 - Marcello Fulchignoni , Principal Investigator, Huygens Atmospheric Structure Instrument, Universit de Paris 7, France 16:25 - John Zarnecki, Principal Investigator, Surface Science Package, Open University, UK 16:30 - Franois Raulin, Co-Investigator, Gas Chromatograph Mass Spectrometer, Universit de Paris 12 - Crteil, France 16:35 - Guy Israel, Principal Investigator, Aerosol Collector and Pyrolyser, Service d'Aronomie/CNRS, France 16:40 - Bruno Bezard, Co-Investigator, Descent Imager/Spectral Radiometer, Laboratoire d'tudes spatiales et d'instrumentation en astrophysique, Observatoire de Paris, France 16:45 - Jonathan Lunine, Interdisciplinary Scientist, Titan surface-atmosphere interactions, LPL/U, Arizona (USA) and INAF/IFSI, Rome (Italy) 16:55 - Questions and AnswersV 17:05 - Coffee break 17:10 - Mars Express: results in the overall context of Martian science, Agustin Chicarro, ESA Mars Express Project Scientist 17:15 - Giovanni Picardi, MARSIS Radar Principal Investigator, University of Rome La Sapienza, Italy Jeffrey Plaut, MARSIS Co-Principal Investigator, NASA/JPL, USA 17:25 - Martin Ptzold, Mars Radio Science Experiment, Principal Investigator, Universitt Koln, Cologne, Germany 17:30 - Jean-Pierre Bibring, OMEGA Principal Investigator, Institut dAstrophysique spatiale, Orsay, France 17:40 - Gerhard Neukum, HRSC Camera Principal Investigator, Freie Universitt Berlin, Germany 17:45 - Questions and Answers 17:55 - Interview opportunities

  13. DNA cleavage at the AP site via β-elimination mediated by the AP site-binding ligands.

    PubMed

    Abe, Yukiko S; Sasaki, Shigeki

    2016-02-15

    DNA is continuously damaged by endogenous and exogenous factors such as oxidation and alkylation. In the base excision repair pathway, the damaged nucleobases are removed by DNA N-glycosylase to form the abasic sites (AP sites). The alkylating antitumor agent exhibits cytotoxicity through the formation of the AP site. Therefore blockage or modulation of the AP site repair pathway may enhance the antitumor efficacy of DNA alkylating agents. In this study, we have examined the effects of the nucleobase-polyamine conjugated ligands (G-, A-, C- and T-ligands) on the cleavage of the AP site. The G- and A-ligands cleaved DNA at the AP site by promoting β-elimination in a non-selective manner by the G-ligand, and in a selective manner for the opposing dT by the A-ligand. These results suggest that the nucleobase-polyamine conjugate ligands may have the potential for enhancement of the cytotoxicities of the AP site. PMID:26777298

  14. Exploring Mars: The Ares Payload Service (APS)

    NASA Astrophysics Data System (ADS)

    Bowen, Justin; Lusignan, Bruce

    1999-08-01

    In last year's Mars Society convention we introduced the results of five years of studies of space launch capability for the second millennium. We concluded that Single Stage to Orbit (SSTO) vehicles such as the Delta Clipper X33, and X34 cannot make it to orbit from the Earth's surface. Whether taking off vertically or horizontally or landing vertically or horizontally, the rocket equations, the performance of available fuels, and the realities of the weight and strength of materials leave no margin for payload. The promised savings from SSTO systems are illusory. However, a configuration that is able to deliver useful payload to orbit is the Single step to Orbit, SsTO, a rocket plane that is released fully fueled, from 35,000 to 40,000 feet altitude. Three approaches have been proposed. The Hot'l and Molnya Corporation designs carry the fueled rocket plane to altitude on the back of a carrier aircraft. In this design the carrier aircraft is Russia's Antonov 225 the world's largest cargo plane. The rocket plane is a modified version of the Buran, Russia's own space shuttle. Another configuration is Kelly Aviation's concept in which the fully fueled rocket plane is towed to altitude by the cargo plane and then released. A third approach is based on the early "X" planes, which were dropped from the belly of the carrier plane. While the rocket equations indicate that these three concepts can deliver useful payloads, the Stanford review found significant advantages to the approach of Pioneer Rocket, in which the rocket plane flies up to the carrier plane with conventional jet engines, docks, and then loads on the oxidizer for the flight to orbit. This architecture has more reasonable abort modes in case of system failure in either aircraft and can deliver a larger final payload to orbit for a given sized carrier. The Stanford recommendation is that the carrier aircraft be the Antonov 225. A design based on this was presented in a report last year. Refinements to the design notably an improved re-entry cooling system and fueling stability analysis were done this year. More technical detail and a proposed international consortium to develop the SSTO is presented in another session of this year's Mars convention. We believe that there will be no human exploration of Mars based on the Shuttle or Expendable launch vehicles, and no resources available except for a cooperative international program. However, just as the world is learning to cooperate in peacekeeping, we hold out the hope that similar cooperation will develop for Mars exploration. With that in mind, this year we asked the question- "How will the human mission get to Mars if it has to use the SsTO for transportation?"

  15. Exploring Mars: the Ares Payload Service (APS)

    NASA Technical Reports Server (NTRS)

    Bowen, Justin; Lusignan, Bruce

    1999-01-01

    In last year's Mars Society convention we introduced the results of five years of studies of space launch capability for the second millennium. We concluded that Single Stage to Orbit (SSTO) vehicles such as the Delta Clipper X33, and X34 cannot make it to orbit from the Earth's surface. Whether taking off vertically or horizontally or landing vertically or horizontally, the rocket equations, the performance of available fuels, and the realities of the weight and strength of materials leave no margin for payload. The promised savings from SSTO systems are illusory. However, a configuration that is able to deliver useful payload to orbit is the Single step to Orbit, SsTO, a rocket plane that is released fully fueled, from 35,000 to 40,000 feet altitude. Three approaches have been proposed. The Hot'l and Molnya Corporation designs carry the fueled rocket plane to altitude on the back of a carrier aircraft. In this design the carrier aircraft is Russia's Antonov 225 the world's largest cargo plane. The rocket plane is a modified version of the Buran, Russia's own space shuttle. Another configuration is Kelly Aviation's concept in which the fully fueled rocket plane is towed to altitude by the cargo plane and then released. A third approach is based on the early "X" planes, which were dropped from the belly of the carrier plane. While the rocket equations indicate that these three concepts can deliver useful payloads, the Stanford review found significant advantages to the approach of Pioneer Rocket, in which the rocket plane flies up to the carrier plane with conventional jet engines, docks, and then loads on the oxidizer for the flight to orbit. This architecture has more reasonable abort modes in case of system failure in either aircraft and can deliver a larger final payload to orbit for a given sized carrier. The Stanford recommendation is that the carrier aircraft be the Antonov 225. A design based on this was presented in a report last year. Refinements to the design notably an improved re-entry cooling system and fueling stability analysis were done this year. More technical detail and a proposed international consortium to develop the SSTO is presented in another session of this year's Mars convention. We believe that there will be no human exploration of Mars based on the Shuttle or Expendable launch vehicles, and no resources available except for a cooperative international program. However, just as the world is learning to cooperate in peacekeeping, we hold out the hope that similar cooperation will develop for Mars exploration. With that in mind, this year we asked the question- "How will the human mission get to Mars if it has to use the SsTO for transportation?"

  16. Simultaneous recording of t-tubular electrical activity and Ca2+-release in heart failure

    NASA Astrophysics Data System (ADS)

    Crocini, C.; Coppini, R.; Ferrantini, C.; Yan, P.; Loew, L.; Tesi, C.; Poggesi, C.; Cerbai, E.; Pavone, F. S.; Sacconi, L.

    2014-05-01

    T-tubules (TT) are invaginations of the surface sarcolemma (SS) that mediate the rapid propagation of the action potential (AP) to the cardiomyocyte core. We employed the advantages of an ultrafast random access multi-photon (RAMP) microscope (Sacconi et al., PNAS 2012) with a double staining approach to optically record t-tubular AP and, simultaneously, the corresponding local Ca2+-release in different positions across the cardiomyocytes. Despite a uniform AP between SS and TT at steady-state stimulation, in control cardiomyocytes we observed a non-negligible be variability of local Ca2+-transient amplitude and kinetics. This variability was significantly reduced by applying 0.1μM Isoproterenol, which increases the opening probability of Ca2+-release units. In the rat heart failure model (HF), we previously demonstrated that some tubular elements fail to propagate AP. We found that the tubules unable to propagate AP, displayed a reduced correspondent Ca2+-transient amplitude as well as a slower Ca2+ rise compared to electrically coupled tubules. Moreover variability of Ca2+-transient kinetics were increased in HF. Finally, TT that did not show AP, occasionally exhibited spontaneous depolarizations that were never accompanied by local Ca2+-release in the absence of any pro-arrhythmogenic stimulation. Simultaneous recording of AP and Ca2+-transient allows us to probe the spatio-temporal variability of Ca2+-release, whereas the investigation of Ca2+-transient in HF discloses an unexpected uncoupling between t-tubular depolarization and Ca2+-release in remodeled tubules. This work was funded by the European Union 7th Framework Program (FP7/2007- 2013) under grant agreement n° 284464, 241526, by the Italian Ministry of University and Research (NANOMAX), and by Telethon-Italy (GGP13162).

  17. Is Ap sub 4 A involved in DNA repair processes

    SciTech Connect

    Gilson, G.; Ebel, J.P.; Remy, P. )

    1988-07-01

    Hepatoma tissue culture (HTAC) cells were incubated in the presence of the alkylating agent N-methyl-N{prime}-nitro-N-nitrosoguanidine (MNNG) to study the variations in the bisnucleosides polyphosphates (Ap{sub 4}X) pool size. A transient but sensitive accumulation of these compounds is observed; if 3-aminobenzamide (3AB) which is a potent inhibitor of the ADP-ribosyltransferase (ADPRT) is added after the MNNG treatment, a more pronounced and persistent accumulation of Ap{sub 4}X can be seen. A moderate heat-shock results also in a small accumulation of Ap{sub 4}X but the shape of the accumulation curve is quite different and the increase of the Ap{sub 4}X pool is not sensitive to the presence of 3AB. However, both MNNG treatment and hyperthermia cause a marked inhibition of protein synthesis. On the other hand, the ADPRT activity is enhanced in the presence of MNNG whereas hyperthermia has little or a slightly inhibitory effect on this activity. These results suggest that MNNG treatment triggers an Ap{sub 4}X accumulation in eukaryotic cells different from that observed after heat-shock and it seems likely that these compounds are involved in the DNA excision repair system in which the ADPRT enzyme is also implicated.

  18. Design and realization of linear APS-based sun sensor

    NASA Astrophysics Data System (ADS)

    Liang, He; Zhang, Jianfu; Lv, Zhengxin; Yu, Chengwu; Jia, Jinzhong

    2013-10-01

    Linear APS-based sun sensor is a kind of sun sensor based on a linear array Active Pixel Sensor (APS) with low power consumption, small size, and small mass. It is integrated with optical, mechanical and electronic technologies. The main function of linear APS-based sun sensor is to realize two-axis measurement of solar aspect angle, determining the attitude of spacecraft. The image of the solar is projected on the linear image sensor through an N-shape aperture in front of it. By comparing the position shift of solar image projection on linear array APS, we can obtain the position of the sun relative to sensor. This paper analyzes the sources of system error and some specific solutions are proposed. The error compensation algorithm in the software designed makes the sun senor meet the accuracy requirements. The performance characteristics are as follows: FOV is +/-64x+/-64 the accuracy of ?-axis is better than 0.02 (3?) in the FOV of less than 45, and better than 0.03 (3?) in other FOV; the accuracy of ?-axis is better than 0.03 (3?) in the whole FOV. Linear APS-based sun sensor was successfully carried by satellite on orbit in October 2012. On-orbit testing showed that it operates normally and the data curves prove the accuracy meets requirements.

  19. Past, Present, and Future of AP Chemistry: A Brief History of Course and Exam Alignment Efforts

    ERIC Educational Resources Information Center

    Magrogan, Serena

    2014-01-01

    As part of the Advanced Placement (AP) Program's commitment to continually enhance alignment with current best practices in college-level learning, the AP Program is currently evaluating and redesigning courses and exams, one of which launched during the 2013-2014 academic school year: AP chemistry. The history of the AP chemistry course and…

  20. AP Report to the Nation: A Closer Look at the Nation and Florida

    ERIC Educational Resources Information Center

    Sawtell, Ellen A.; Gillie, Jacqueline M.; Smith, Patricia Z.

    2012-01-01

    In February 2012, the College Board published The 8th Annual AP Report to the Nation. This session provides a deeper dive into key information for the United States with an emphasis on Florida, and participants hear how one school in Florida utilizes AP Potential™ to help build their AP Program. Participants also learn about AP participation and…

  1. Past, Present, and Future of AP Chemistry: A Brief History of Course and Exam Alignment Efforts

    ERIC Educational Resources Information Center

    Magrogan, Serena

    2014-01-01

    As part of the Advanced Placement (AP) Program's commitment to continually enhance alignment with current best practices in college-level learning, the AP Program is currently evaluating and redesigning courses and exams, one of which launched during the 2013-2014 academic school year: AP chemistry. The history of the AP chemistry course and

  2. Bilberry and bilberry press cake as sources of dietary fibre

    PubMed Central

    Aura, Anna-Marja; Holopainen-Mantila, Ulla; Sibakov, Juhani; Kössö, Tuija; Mokkila, Mirja; Kaisa, Poutanen

    2015-01-01

    Background Dietary recommendations for Nordic countries urge the use of plant foods as a basis for healthy nutrition. Currently, the level of dietary fibre (DF) intake is not adequate. Berries are an elementary part of the recommended Nordic healthy diet and could be consumed in higher amounts. Materials and methods Finnish bilberries and a bilberry press cake from juice processing were studied for DF content, carbohydrate composition, and non-carbohydrate fibre content, which was analysed as sulphuric acid insoluble and soluble material. The microstructure of all samples was also studied using light microscopy and toluidine blue O, calcofluor, and acid fuchsin staining. Results The total DF contents of fresh and freeze-dried bilberries and the press cake were 3.0, 24.1, and 58.9%, respectively. Most of the DF was insoluble. Only about half of it was carbohydrate, the rest being mostly sulphuric acid–insoluble material, waxy cutin from skins, and resilient seeds. Bilberry seeds represented over half of the press cake fraction, and in addition to skin, they were the major DF sources. Microscopy revealed that skins in the press cake were intact and the surface of the seeds had thick-walled cells. Conclusions Bilberry press cake is thus a good source of insoluble non-carbohydrate DF, and could be used to provide DF-rich foods to contribute to versatile intake of DF. PMID:26652738

  3. A Study on the Specifications of Cold Pressed Colza Oil.

    PubMed

    Yazdani-Nasab, Zahra; Piravi-Vanak, Zahra

    2015-01-01

    Cold pressed oil extraction is the preferred method for seeds with high contents of oil, such as colza. Generally speaking, expeller pressing is less complex, more cost efficient and safer than solvent extraction. Moreover, cold pressed oils retain their natural properties better. Cold pressed colza oil has been found to have numerous health benefits. This was an original and unique study conducted as part of the research for the international Codex standard for cold pressed fats and oils, and aims to examine the chemical properties of two varieties of Iranian colza seed, Hyola and Okapi. The studied factors included (a) chemical properties, and (b) physicochemical and quality characteristics. Based on our findings, both varieties of colza seeds in this study had satisfactory levels of oleic and linoleic acid, and no trans-fatty acids. Although both samples had good nutritional properties, the Hyola variety was higher in oleic acid, indicating better oxidative stability. Due to the considerable amounts of β-sitosterol in both varieties, they may be effective in reducing cholesterol and preventing cancer. PMID:26043928

  4. Results of press-fit stems in revision knee arthroplasties.

    PubMed

    Wood, Gavin C; Naudie, Douglas D R; MacDonald, Steven J; McCalden, Richard W; Bourne, Robert B

    2009-03-01

    The ideal method of stem fixation in revision knee arthroplasty is controversial with advantages and disadvantages for cemented and press-fit designs. Studies have suggested cemented revision knee stems may provide better long-term survival. The aim of this study was to report our experience with press-fit uncemented stems and metaphyseal cement fixation in a selected series of patients undergoing revision total knee arthroplasty. One hundred twenty-seven patients (135 knees) who underwent revision total knee arthroplasty using a press-fit technique (press-fit diaphyseal fixation and cemented metaphyseal fixation) were reviewed. Minimum followup was 2 years (mean, 5 years; range, 2-12 years). A Kaplan-Meier survivorship analysis using an end point of revision surgery or radiographic loosening was used to determine probability of survival at 5 and 10 years. Of the 127 patients (135 knees), 31 patients (36 knees) died and two patients (two knees) were lost to followup. Six patients (six knees) had revisions at a mean of 3.5 years (range, 1-8 years). Kaplan-Meier survivorship analysis revealed a probability of survival free of revision for aseptic loosening of 98% at 12 years. Survivorship of press-fit stems for revision knee arthroplasty is comparable to reported survivorship of cemented stem revision knee arthroplasty. Radiographic analysis has shown continued satisfactory appearances regardless of constraint, stem size, and augmentations. PMID:19034597

  5. Quality parameters for cold pressed edible argan oils.

    PubMed

    Matthäus, Bertrand

    2013-01-01

    Argan oil belongs to the high-price vegetable oils on the market. Therefore, consumers have the right to purchase a high-quality product. The quality of edible vegetable oils is defined in food standards in which sensory quality is the most important feature. Additional parameters are defined to assess the identity of oils or to evaluate their oxidative state. The sensory quality of cold pressed argan oil is altered if the production has not been performed with reasonable care regarding raw material and extraction. Only oil from roasted seeds extracted by a screw-press had a sufficient sensory quality over a period of 20 weeks without unacceptable sensory attributes. Under accelerated storage conditions oil from roasted seeds extracted by a screw-press remained below the limits given by the Codex Alimentarius or the German guideline for Edible Fats and Oils for peroxide and totox value. Oil from unroasted seeds or oil from goat-digested roasted seeds and extracted by a screw-press, as well as oil from roasted seeds traditionally extracted, exceeded these limits. Initial oxidative stability of oil from unroasted seeds was significantly lower than that of the other oils. After 35 days under accelerated storage, oil from roasted seeds obtained using a screw-press showed the highest oxidative stability. Moreover, tocopherol and phytosterol compositions are useful features of argan oil. PMID:23472455

  6. An Update of Freedom of the Press and Information in Latin America and the Caribbean.

    ERIC Educational Resources Information Center

    Garrison, Bruce; Munoz, Julio E.

    This paper is based on a review of the literature that included reports from the Inter-American Press Association's general assembly in Los Angeles in October 1984, the mid-year meeting of the Inter-American Press Association in Panama City in March 1985, and the 1983 world press freedom review of the International Press Institute. Other material…

  7. 22 CFR 9b.4 - Department of State building press pass for technical crews.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Department of State building press pass for technical crews. 9b.4 Section 9b.4 Foreign Relations DEPARTMENT OF STATE GENERAL REGULATIONS GOVERNING DEPARTMENT OF STATE PRESS BUILDING PASSES § 9b.4 Department of State building press pass for technical crews. Department of State press...

  8. 22 CFR 9b.1 - Press access to the Department of State.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Press access to the Department of State. 9b.1 Section 9b.1 Foreign Relations DEPARTMENT OF STATE GENERAL REGULATIONS GOVERNING DEPARTMENT OF STATE PRESS BUILDING PASSES § 9b.1 Press access to the Department of State. (a) Media correspondents without valid Department of State press building...

  9. 22 CFR 9b.3 - Press correspondents employed by foreign media organizations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Press correspondents employed by foreign media... OF STATE PRESS BUILDING PASSES § 9b.3 Press correspondents employed by foreign media organizations... media organizations must: (a) Present to the Office of Press Relations, Department of State,...

  10. 22 CFR 9b.1 - Press access to the Department of State.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Press access to the Department of State. 9b.1 Section 9b.1 Foreign Relations DEPARTMENT OF STATE GENERAL REGULATIONS GOVERNING DEPARTMENT OF STATE PRESS BUILDING PASSES § 9b.1 Press access to the Department of State. (a) Media correspondents without valid Department of State press building...

  11. 22 CFR 9b.1 - Press access to the Department of State.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Press access to the Department of State. 9b.1 Section 9b.1 Foreign Relations DEPARTMENT OF STATE GENERAL REGULATIONS GOVERNING DEPARTMENT OF STATE PRESS BUILDING PASSES § 9b.1 Press access to the Department of State. (a) Media correspondents without valid Department of State press building...

  12. A survey of Ap stars for weak longitudinal magnetic fields

    NASA Astrophysics Data System (ADS)

    Auriere, M.; Silvester, J.; Wade, G. A.; Bagnulo, S.; Donati, J. F.; Johnson, N.; Landstreet, J. D.; Lignieres, F.; Lueftinger, T.; Mouillet, M.; Paletou, F.; Petit, P.; Strasser, S.

    2004-10-01

    We are conducting a magnetic survey of a sample of about 30 spectroscopically-identified Ap stars (selected from the HD catalogue), but with faint or previously undetected magnetic fields. We use the MuSiCoS spectropolarimeter at Telescope Bernard Lyot (Pic du Midi Observatory, France) and the cross-correlation technique Least Squares Deconvolution (LSD; Donati et al. 1997). For 24 studied stars, we have obtained 21 detections of Stokes V Zeeman signatures (data quality and phase coverage may explain our lack of detection of any field in some objects). Our results suggest that all Ap stars are magnetic and, furthermore, that there may exist a minimum field strength for which Ap-type characteristics are produced.

  13. Ground vibration model studies for APS storage ring

    SciTech Connect

    Koul, R.K.

    1994-07-01

    An analytical ground vibration model is developed for study of the vibration effects on the beam motion in the Advanced Photon Source (APS) storage ring. The different physical parameters associated with the wave characteristics and the vibration modes needed for the study are taken from the vibration studies carried out at the APS site. The implementation has been carried out using Mathematica{trademark}. The study is carried out for the frequency range 1--35 Hz, with a number of sources changing from one through ten. The program written in Mathematica{trademark}, calculates orbit distortion, beta wave change, tune change, dispersion change, and chromaticity change. However, the main parameter studied for the APS storage ring has been the orbit distortion. The merit factor associated with different modes excited by the vibrations has been calculated.

  14. Autosomal recessive spastic tetraplegia caused by AP4M1 and AP4B1 gene mutation: expansion of the facial and neuroimaging features.

    PubMed

    Tüysüz, Beyhan; Bilguvar, Kaya; Koçer, Naci; Yalçınkaya, Cengiz; Çağlayan, Okay; Gül, Ece; Sahin, Sezgin; Çomu, Sinan; Günel, Murat

    2014-07-01

    Adaptor protein complex-4 (AP4) is a component of intracellular transportation of proteins, which is thought to have a unique role in neurons. Recently, mutations affecting all four subunits of AP4 (AP4M1, AP4E1, AP4S1, and AP4B1) have been found to cause similar autosomal recessive phenotype consisting of tetraplegic cerebral palsy and intellectual disability. The aim of this study was analyzing AP4 genes in three new families with this phenotype, and discussing their clinical findings with an emphasis on neuroimaging and facial features. Using homozygosity mapping followed by whole-exome sequencing, we identified two novel homozygous mutations in AP4M1 and a homozygous deletion in AP4B1 in three pairs of siblings. Spastic tetraplegia, microcephaly, severe intellectual disability, limited speech, and stereotypic laughter were common findings in our patients. All patients also had similar facial features consisting of coarse and hypotonic face, bitemporal narrowing, bulbous nose with broad nasal ridge, and short philtrum which were not described in patients with AP4M1 and AP4B1 mutations previously. The patients presented here and previously with AP4M1, AP4B1, and AP4E1 mutations shared brain abnormalities including asymmetrical ventriculomegaly, thin splenium of the corpus callosum, and reduced white matter volume. The patients also had hippocampal globoid formation and thin hippocampus. In conclusion, disorders due to mutations in AP4 complex have similar neurological, facial, and cranial imaging findings. Thus, these four genes encoding AP4 subunits should be screened in patients with autosomal recessive spastic tetraplegic cerebral palsy, severe intellectual disability, and stereotypic laughter, especially with the described facial and cranial MRI features. PMID:24700674

  15. The fundamental parameters of the Ap star 78 Virginis. Could 78 Vir be a rapidly oscillating Ap star?

    NASA Astrophysics Data System (ADS)

    Perraut, K.; Cunha, M.; Brandão, I.; Loridat, J.; Mourard, D.; Meilland, A.; Nardetto, N.; McAlister, H.; ten Brummelaar, T. A.; Sturmann, J.; Sturmann, L.; Turner, N.; Farrington, C.; Vargas, N.

    2015-07-01

    Context. Determining the effective temperature of Ap stars, including the roAp stellar pulsators, is a difficult task owing to their strong magnetic field and their related spotted surfaces. It is, however, an important step towards constraining models of their complex atmosphere and testing proposed pulsation excitation mechanisms. Aims: Using the unique angular resolution provided by long-baseline visible interferometry, we aim at deriving accurate angular diameters of a number of Ap targets, so as to determine their unbiased effective temperature (Teff) and their accurate position in the Hertzsprung-Russell diagram, to estimate their mass and age, and to test non-adiabatic pulsation models. Interferometric results on four Ap stars have been published in earlier works. Here we report the results on a fifth, significantly hotter star. Methods: We observed 78 Vir with the visible spectrograph VEGA installed at the combined focus of the CHARA long-baseline optical array. We derived the limb-darkened diameter of this Ap star from our interferometric measurements. Based on photometric and spectroscopic data available in the literature, we estimated the star's bolometric flux and used it, in combination with its parallax and angular diameter, to determine the star's luminosity and effective temperature. We then used the derived fundamental parameters to perform a non-adiabatic pulsation analysis. Results: We determined a limb-darkened angular diameter of 0.346 ± 0.006 mas and deduced a linear radius of R = 2.11 ± 0.04 R⊙. Considering a bolometric flux of 2.73 ± 0.20 10-7 erg/cm2/s we obtained a luminosity of L/L⊙ = 27 ± 2 and an effective temperature of Teff = 9100 ± 190 K. The non-adiabatic pulsation modeling allows us to predict that high overtone pulsations could be excited in 78 Vir at frequencies ranging from 1.2 to 1.9 mHz, provided that the magnetic field is capable of suppressing envelope convection in the polar regions. Conclusions: Visible long-baseline interferometry is a unique means of deriving accurate fundamental parameters of Ap stars. The Ap star 78 Vir is found to be a promising roAp-star candidate and one that would allow us to extend recent tests on the roAp stars' excitation mechanism towards the blue edge of the instability strip. Asteroseismic data of this star would, therefore, be of strong interest. Based on observations made with the VEGA/CHARA spectro-interferometer.

  16. Characterization of a protein phosphatase 2A holoenzyme that dephosphorylates the clathrin adaptors AP-1 and AP-2.

    PubMed

    Ricotta, Doris; Hansen, Jens; Preiss, Carolin; Teichert, Dominic; Höning, Stefan

    2008-02-29

    The AP-2 complex is a key factor in the formation of endocytic clathrin-coated vesicles (CCVs). AP-2 sorts and packages cargo membrane proteins into CCVs, binds the coat protein clathrin, and recruits numerous other factors to the site of vesicle formation. Structural information on the AP-2 complex and biochemical work have allowed understanding its function on the molecular level, and recent studies showed that cycles of phosphorylation are key steps in the regulation of AP-2 function. The complex is phosphorylated on both large subunits (alpha- and beta2-adaptins) as well as at a single threonine residue (Thr-156) of the medium subunit mu2. Phosphorylation of mu2 is necessary for efficient cargo recruitment, whereas the functional context of the large subunit phosphorylation is unknown. Here, we show that the subunit phosphorylation of AP-2 exhibits striking differences, with calculated half-lives of <1 min for mu2, approximately 25 min for beta2, and approximately 70 min for alpha. We were also able to purify a phosphatase that dephosphorylates the mu2 subunit. The enzyme is a member of the protein phosphatase 2A family and composed of a catalytic Cbeta subunit, a scaffolding Abeta subunit, and a regulatory Balpha subunit. RNA interference knock down of the latter subunit in HeLa cells resulted in increased levels of phosphorylated adaptors and altered endocytosis, showing that a specific PP2A holoenzyme is an important regulatory enzyme in CCV-mediated transport. PMID:18158287

  17. Two WXXF-based motifs in NECAPs define the specificity of accessory protein binding to AP-1 and AP-2

    PubMed Central

    Ritter, Brigitte; Denisov, Alexei Yu; Philie, Jacynthe; Deprez, Christophe; Tung, Elaine C; Gehring, Kalle; McPherson, Peter S

    2004-01-01

    The adaptor proteins AP-2 and AP-1/GGAs are essential components of clathrin coats at the plasma membrane and trans-Golgi network, respectively. The adaptors recruit accessory proteins to clathrin-coated pits, which is dependent on the adaptor ear domains engaging short peptide motifs in the accessory proteins. Here, we perform an extensive mutational analysis of a novel WXXF-based motif that functions to mediate the binding of an array of accessory proteins to the α-adaptin ear domain of AP-2. Using nuclear magnetic resonance and mutational studies, we identified WXXF-based motifs as major ligands for a site on the α-ear previously shown to bind the DPW-bearing proteins epsin 1/2. We also defined the determinants that allow for specific binding of the α-ear motif to AP-2 as compared to those that allow a highly related WXXF-based motif to bind to the ear domains of AP-1/GGAs. Intriguingly, placement of acidic residues around the WXXF cores is critical for binding specificity. These studies provide a structural basis for the specific recruitment of accessory proteins to appropriate sites of clathrin-coated vesicle formation. PMID:15359277

  18. Psychosocial Assessment of Artificial Pancreas (AP): Commentary and Review of Existing Measures and Their Applicability in AP Research

    PubMed Central

    Hood, Korey K.; Weissberg-Benchell, Jill; Aldred, Chris; Oliver, Nick; Laffel, Lori

    2015-01-01

    Abstract Aim: This study aimed to systematically review the evidence base for the use of existing psychological and psychosocial measures suitable for use in artificial pancreas (AP) research. Materials and Methods: This systematic review of published literature, gray literature, previous systematic reviews, and qualitative and economic studies was conducted using terms and abbreviations synonymous with diabetes, AP, and quality of life (QoL). Results: Two hundred ninety-two abstracts were identified that reported psychosocial assessment of diabetes-related technologies. Of these, nine met the inclusion criteria and were included. Only four of 103 ongoing trials evaluated psychosocial aspects as an outcome in the trial. Of these, treatment satisfaction, acceptance and use intention of AP, fear of hypoglycemia episodes, satisfaction with AP, and an unspecified QoL measure were used. Conclusions: A better understanding of the psychosocial side of AP systems and the extent to which human factors play a role in the uptake and efficient use of these systems will ultimately lead to the most benefit for people with diabetes. PMID:25549042

  19. Release and Skin Permeation of Scopolamine From Thin Polymer Films in Relation to Thermodynamic Activity.

    PubMed

    Kunst, Anders; Lee, Geoffrey

    2016-04-01

    The object was to demonstrate if the diffusional flux of the drug out of a drug-in-adhesive-type matrix and its subsequent permeation through an excised skin membrane is a linear function of the drug's thermodynamic activity in the thin polymer film. The thermodynamic activity, ap(*), is defined here as the degree of saturation of the drug in the polymer. Both release and release/permeation of scopolamine base from 3 different poylacrylate pressure-sensitive adhesives (PSAs) were measured. The values for ap(*) were calculated using previous published saturation solubilities, wp(s), of the drug in the PSAs. Different rates of release and release/permeation were determined between the 3 PSAs. These differences could be accounted for quantitatively by correlating with ap(*) rather than the concentration of the drug in the polymer films. At similar values for ap(*) the same release or release/permeation rates from the different polymers were measured. The differences could not be related to cross-linking or presence of ionizable groups of the polymers that should influence diffusivity. PMID:27019963

  20. The AP-1 transcription factor homolog Pf-AP-1 activates transcription of multiple biomineral proteins and potentially participates in Pinctada fucata biomineralization

    PubMed Central

    Zheng, Xiangnan; Cheng, Minzhang; Xiang, Liang; Liang, Jian; Xie, Liping; Zhang, Rongqing

    2015-01-01

    Activator protein-1 (AP-1) is an important bZIP transcription factor that regulates a series of physiological processes by specifically activating transcription of several genes, and one of its well-chartered functions in mammals is participating in bone mineralization. We isolated and cloned the complete cDNA of a Jun/AP-1 homolog from Pinctada fucata and called it Pf-AP-1. Pf-AP-1 had a highly conserved bZIP region and phosphorylation sites compared with those from mammals. A tissue distribution analysis showed that Pf-AP-1 was ubiquitously expressed in P. fucata and the mRNA level of Pf-AP-1 is extremely high in mantle. Pf-AP-1 expression was positively associated with multiple biomineral proteins in the mantle. The luciferase reporter assay in a mammalian cell line showed that Pf-AP-1 significantly up-regulates the transcriptional activity of the promoters of KRMP, Pearlin, and Prisilkin39. Inhibiting the activity of Pf-AP-1 depressed the expression of multiple matrix proteins. Pf-AP-1 showed a unique expression pattern during shell regeneration and pearl sac development, which was similar to the pattern observed for biomineral proteins. These results suggest that the Pf-AP-1 AP-1 homolog is an important transcription factor that regulates transcription of several biomineral proteins simultaneously and plays a role in P. fucata biomineralization, particularly during pearl and shell formation. PMID:26404494

  1. Analysis of the planning and scheduling functionality in APS systems

    NASA Astrophysics Data System (ADS)

    Steger-Jensen, Kenn; Hvolby, Hans-Henrik

    2001-10-01

    The paper discusses the basic functionality of planning and scheduling in Advanced Planning and Scheduling systems (APS). Three basic planning options - unconstrained planning, constrained planning and optimization are analyzed by use of theory and examples based on test of an APS system. Even though the planning functionality are radically improved compared to MRP and MRP II, the balance between the objectives are found to be too rigid. This conclusion is based on a number of examples, comparing the outcome of different objectives such as constraints based planning versus optimized planning.

  2. Status of the Advanced Photon Source (APS) linear accelerator

    SciTech Connect

    White, M.; Arnold, N.; Berg, W.; Cours, A.; Fuja, R.; Grelick, A.; Ko, K.; Qian, Y.; Russell, T.; Sereno, N.

    1994-09-01

    A 2856-MHz S-band, electron-positron linear accelerator (linac) has been constructed at the Advanced Photon Source (APS). It is the source of particles and the injector for the other APS accelerators, and linac commissioning is well underway. The linac is operated 24 hours per day to support linac beam studies and rf conditioning, as well as positron accumulator ring and synchrotron commissioning studies. The design goal for accelerated positron current is 8-mA, and has been met. Maximum positron energy to date is 420-MeV, approaching the design goal of 450-MeV. The linac design and its performance are discussed.

  3. Magnetic fields in A stars besides Ap stars

    NASA Astrophysics Data System (ADS)

    Kochukhov, O.

    2014-11-01

    I review ongoing efforts to understand the incidence of magnetism in intermediate-mass stars that are different from the magnetic Ap stars. This includes the search for magnetic fields in chemically peculiar stars of the Am and HgMn types as well as in normal A and late-B stars. I discuss different techniques for detecting weak stellar magnetic fields, and present a critical evaluation of recent magnetic detections in non-Ap stars. Special attention is given to the magnetic status of HgMn stars and to the discovery of weak polarization signatures in Sirius and Vega.

  4. On the abundance of Europium. [in Ap and Am stars

    NASA Technical Reports Server (NTRS)

    Hartoog, M. R.; Cowley, C. R.; Adelman, S. J.

    1974-01-01

    The inclusion of the effects of hyperfine splitting can significantly lower the abundance estimate of Eu from singly ionized lines which lie on the flat portion of the curve of growth. In the 21 cool Ap stars studied by Adelman and the five Am stars studied by Smith, the Eu abundance was reduced by 0.4 dex on the average. In individual cases, the reductions were as great as 0.9 dex. This makes the Eu abundance comparable to that of its neighboring rare earths Sm and Gd in the Ap stars and less than Sm and Gd in the Am stars, but still substantially overabundant with respect to solar values.

  5. Joining of ceramics of different biofunction by hot isostatic pressing

    SciTech Connect

    Li, Jianguo . Center for Dental Technology and Biomaterials); Harmansson, L. ); Soeremark, R. . Dept. of Prosthodontics)

    1993-10-01

    Monolithic zirconia (Z) and zirconia-hydroxyapatite (Z/HA) composites were joined by cold isostatic pressing (CIP at 300 MPa) and subsequently by glass-encapsulated hot isostatic pressing (HIP at 1225 C, 1 h and 200 MPa). The physical and mechanical properties of the materials were measured. The fracture surface was studied using a light microscope. The results indicate a strength level of the joint similar to that of the corresponding composite material (Z/HA), 845 and 860 MPa, respectively. Similar experiments with monolithic alumina (A) and alumina-hydroxyapatite (A/HA) were carried out without success. Cracking occurred in the joint area during the cold isostatic pressing process. It seems that ceramics with high green strength and similar green density are essential when joining ceramics by combined CIP and HIP processes.

  6. Crack toughness evaluation of hot pressed and forged beryllium

    NASA Technical Reports Server (NTRS)

    Jones, M. H.; Bubsey, R. T.; Brown, W. F., Jr.

    1971-01-01

    Beryllium fracture toughness test specimens were fatigue cracked using reversed cycling with a compression load two to three times the tension load. In worked beryllium, textures may be produced which result in fatigue cracks that are out of plane with the starter notch. Specimens of hot pressed stock exhibited load displacement records which were nonlinear throughout their course. Fracture specimens of both hot pressed and forged stock showed essentially no reduction of thickness and the fracture surfaces were flat and normal to the load axis. However, the stress intensity factor at maximum load increased with decreasing thickness. Load-displacement and electric potential records for the hot pressed beryllium specimens exhibited several anomalies such as negative residual crack mouth displacements and a decrease in electrical potential with increasing load.

  7. Solutions to Challenges Facing a University Digital Library and Press

    PubMed Central

    D'Alessandro, Michael P.; Galvin, Jeffrey R.; Colbert, Stephana I.; D'Alessandro, Donna M.; Choi, Teresa A.; Aker, Brian D.; Carlson, William S.; Pelzer, Gay D.

    2000-01-01

    During the creation of a university digital library and press intended to serve as a medical reference and education tool for health care providers and their patients, six distinct and complex digital publishing challenges were encountered. Over nine years, through a multidisciplinary approach, solutions were devised to the challenges of digital content ownership, management, mirroring, translation, interactions with users, and archiving. The result is a unique, author-owned, internationally mirrored, university digital library and press that serves as an authoritative medical reference and education tool for users around the world. The purpose of this paper is to share the valuable digital publishing lessons learned and outline the challenges facing university digital libraries and presses. PMID:10833161

  8. Method for hot pressing irregularly shaped refractory articles

    DOEpatents

    Steinkamp, William E.; Ballard, Ambrose H.

    1982-01-01

    The present invention is directed to a method for hot pressing irregularly haped refractory articles with these articles of varying thickness being provided with high uniform density and dimensional accuracy. Two partially pressed compacts of the refractory material are placed in a die cavity between displaceable die punches having compact-contacting surfaces of the desired article configuration. A floating, rotatable block is disposed between the compacts. The displacement of the die punches towards one another causes the block to rotate about an axis normal to the direction of movement of the die punches to uniformly distribute the pressure loading upon the compacts for maintaining substantially equal volume displacement of the powder material during the hot pressing operation.

  9. Validation of the new trapped environment AE9/AP9/SPM at low Earth orbit

    NASA Astrophysics Data System (ADS)

    Badavi, Francis F.

    2014-09-01

    The completion of the international space station (ISS) in 2011 has provided the space research community an ideal proving ground for future long duration human activities in space. Ionizing radiation measurements in ISS form the ideal tool for the validation of radiation environmental models, nuclear transport codes and nuclear reaction cross sections. Indeed, prior measurements on the space transportation system (STS; shuttle) provided vital information impacting both the environmental models and the nuclear transport code developments by indicating the need for an improved dynamic model of the low Earth orbit (LEO) trapped environment. Additional studies using thermo-luminescent detector (TLD), tissue equivalent proportional counter (TEPC) area monitors, and computer aided design (CAD) model of earlier ISS configurations, confirmed STS observations that, as input, computational dosimetry requires an environmental model with dynamic and directional (anisotropic) behavior, as well as an accurate six degree of freedom (DOF) definition of the vehicle attitude and orientation along the orbit of ISS. At LEO, a vehicle encounters exposure from trapped particles and attenuated galactic cosmic rays (GCR). Within the trapped field, a challenge arises from properly estimating the amount of exposure acquired. There exist a number of models to define the intensities of the trapped particles during the solar quiet and active times. At active times, solar energetic particles (SEP) generated by solar flare or coronal mass ejection (CME) also contribute to the exposure at high northern and southern latitudes. Among the more established trapped models are the historic and popular AE8/AP8, dating back to the 1980s, the historic and less popular CRRES electron/proton, dating back to 1990s and the recently released AE9/AP9/SPM. The AE9/AP9/SPM model is a major improvement over the older AE8/AP8 and CRRES models. This model is derived from numerous measurements acquired over four solar cycles dating back to the 1970s, roughly representing 40 years of data collection. In contrast, the older AE8/AP8 and CRRES models were limited to only a few months of measurements taken during the prior solar minima and maxima. The dual goal of this paper is to first validate the AE8/AP8 and AE9/AP9/SPM trapped models against ISS dosemetric measurements for a silicon based detector, to assess the improvements in the AE9/AP9/SPM model as compared to AE8/AP8 model. The validation is done at selected target points within ISS-6A configuration during its passage through the south Atlantic anomaly (SAA). For such validation, only the isotropic spectrum of either model is needed. As a second goal, the isotropic spectra of both trapped models are re-casted into anisotropic spectra by modulating them with a measurement derived angular formalism which is applicable to trapped protons. Since at LEO electrons have minimal exposure contribution, the paper ignores the AE8 and AE9 component of the models and presents the angular validation of AP8 and AP9 against measurements from the compact environment anomaly sensor (CEASE) science instrument package, flown onboard the tri-service experiment-5 (TSX-5) satellite during the period of June 2000-July 2006. The spin stabilized satellite was flown in a 410 × 1710 km, 69° inclination orbit, allowing it to be exposed to a broad range of LEO regime. Particular emphasize is put on the validation of proton flux profiles at differential 40 MeV and integral >40 MeV, in the vicinity of SAA where protons exhibit east-west (EW) anisotropy and have a relatively narrow pitch angle distribution. Within SAA, the EW anisotropy results in different level of exposure to each side of CEASE instrument package, allowing the extraction of anisotropic proton spectra from the measurements. While the magnitude of the EW effect at LEO depends on a multitude of factors such as trapped proton energy, orientation of the spacecraft along the velocity vector and altitude of the spacecraft, for this part, the paper draws quantitative conclusions on the combined effect of proton pitch angle and EW anomaly.

  10. Accuracy of press reports on gamma-ray astronomy

    NASA Astrophysics Data System (ADS)

    Schaefer, Bradley E.; Nemiroff, Robert J.; Hurley, Kevin

    2000-09-01

    Most Americans learn about modern science from press reports, while such articles have a bad reputation among scientists. We have performed a study of 148 news articles on gamma-ray astronomy to quantitatively answer the questions ``How accurate are press reports of gamma-ray astronomy?'' and ``What fraction of the basic claims in the press are correct?'' We have taken all articles on the topic from five news sources (UPI, New York Times, Sky & Telescope, Science News, and five middle-sized city newspapers) for one decade (1987-1996) We found an average rate of roughly one trivial error every two articles, while none of our 148 articles significantly mislead the reader or misrepresented the science. This quantitative result is in stark contrast to the nearly universal opinion among scientists that the press frequently butchers science stories. So a major result from our study is that reporters should be rehabilitated into the good graces of astrophysicists, since they actually are doing a good job. For our second question, we rated each story with the probability that its basic new science claim is correct. We found that the average probability over all stories is 70%. Since the reporters and the scientists are both doing good jobs, then why is 30% of the science you read in the press wrong? The reason is that the nature of news reporting is to present front-line science and the nature of front-line science is that reliable conclusions have not yet been reached. The combination of these two natures forces fast breaking science news to have frequent incorrect ideas that are subsequently identified and corrected. So a second major result from our study is to make the distinction between textbook science (with reliabilities near 100%) and front-line science which you read about in the press (with reliabilities near 70%). .

  11. Process design of press hardening with gradient material property influence

    SciTech Connect

    Neugebauer, R.; Schieck, F.; Rautenstrauch, A.

    2011-05-04

    Press hardening is currently used in the production of automotive structures that require very high strength and controlled deformation during crash tests. Press hardening can achieve significant reductions of sheet thickness at constant strength and is therefore a promising technology for the production of lightweight and energy-efficient automobiles. The manganese-boron steel 22MnB5 have been implemented in sheet press hardening owing to their excellent hot formability, high hardenability, and good temperability even at low cooling rates. However, press-hardened components have shown poor ductility and cracking at relatively small strains. A possible solution to this problem is a selective increase of steel sheet ductility by press hardening process design in areas where the component is required to deform plastically during crash tests. To this end, process designers require information about microstructure and mechanical properties as a function of the wide spectrum of cooling rates and sequences and austenitizing treatment conditions that can be encountered in production environments. In the present work, a Continuous Cooling Transformation (CCT) diagram with corresponding material properties of sheet steel 22MnB5 was determined for a wide spectrum of cooling rates. Heating and cooling programs were conducted in a quenching dilatometer. Motivated by the importance of residual elasticity in crash test performance, this property was measured using a micro-bending test and the results were integrated into the CCT diagrams to complement the hardness testing results. This information is essential for the process design of press hardening of sheet components with gradient material properties.

  12. Comparison of concentric and eccentric bench press repetitions to failure.

    PubMed

    Kelly, Stephen B; Brown, Lee E; Hooker, Steven P; Swan, Pamela D; Buman, Matthew P; Alvar, Brent A; Black, Laurie E

    2015-04-01

    Eccentric muscle actions (ECC) are characterized by muscle lengthening, despite actin-myosin crossbridge formation. Muscles acting eccentrically are capable of producing higher levels of force compared with muscles acting concentrically. The purpose of this study was to determine whether ECC bench press yields greater strength than concentric (CON) as determined by 1 repetition maximum (1RM). Additionally, a comparison was made examining differences in the number of repetitions to failure at different relative intensities of 1RM. Thirty healthy men (age = 24.63 ± 5.6 years) were tested for 1RM in CON and ECC bench press and the number of repetitions completed at 60, 70, 80, and 90% 1RM. For CON repetitions, the weight was mechanically lowered to the chest, and the participant pressed it up until the elbows were fully extended. The ECC bench press consisted of lowering a barbell from a fully extended elbow position to the chest in a continuous controlled manner for 3 seconds as determined by electronic metronome. Paired t-tests showed that ECC 1RM (115.99 ± 31.08 kg) was significantly (p ≤ 0.05) greater than CON 1RM (93.56 ± 26.56 kg), and the number of repetitions completed at 90% 1RM was significantly (p ≤ 0.05) greater in ECC (7.67 ± 3.24) as compared with CON (4.57 ± 2.21). There were no significant differences in number of completed repetitions during CON and ECC bench press at 60, 70, and 80% 1RM. These data indicate that ECC actions yield increased force capabilities (∼120%) as compared with CON in the bench press and may be less prone to fatigue, especially at higher intensities. These differences suggest a need to develop unique strategies for training eccentrically. PMID:25268291

  13. Process design of press hardening with gradient material property influence

    NASA Astrophysics Data System (ADS)

    Neugebauer, R.; Schieck, F.; Rautenstrauch, A.

    2011-05-01

    Press hardening is currently used in the production of automotive structures that require very high strength and controlled deformation during crash tests. Press hardening can achieve significant reductions of sheet thickness at constant strength and is therefore a promising technology for the production of lightweight and energy-efficient automobiles. The manganese-boron steel 22MnB5 have been implemented in sheet press hardening owing to their excellent hot formability, high hardenability, and good temperability even at low cooling rates. However, press-hardened components have shown poor ductility and cracking at relatively small strains. A possible solution to this problem is a selective increase of steel sheet ductility by press hardening process design in areas where the component is required to deform plastically during crash tests. To this end, process designers require information about microstructure and mechanical properties as a function of the wide spectrum of cooling rates and sequences and austenitizing treatment conditions that can be encountered in production environments. In the present work, a Continuous Cooling Transformation (CCT) diagram with corresponding material properties of sheet steel 22MnB5 was determined for a wide spectrum of cooling rates. Heating and cooling programs were conducted in a quenching dilatometer. Motivated by the importance of residual elasticity in crash test performance, this property was measured using a micro-bending test and the results were integrated into the CCT diagrams to complement the hardness testing results. This information is essential for the process design of press hardening of sheet components with gradient material properties.

  14. Canning Of Powdered Metal For Hot Isostatic Pressing

    NASA Technical Reports Server (NTRS)

    Juhas, John J.

    1989-01-01

    Quality of specimen enhanced by improved canning process. Method developed for canning specimens for hot isostatic pressing. Specimen placed inside refractory-metal ring, then sandwiched between two refractory-metal face sheets. Assembly placed inside die, then positioned in vacuum hot press. Heated to set temperature at prescribed vacuum to burn off all of binder in specimen. Advantages: powder-metallurgy composite totally purged of binder sealed in can in single operation, maintains size, shape, and uniformity of specimen. Weld region does not recrystallize, and little possibility of cracking.

  15. New technique of machining high precision mirror surface press roller

    NASA Astrophysics Data System (ADS)

    Hongsen, Deng

    1991-03-01

    High precision mirror surface press roller machining technique of corrosion and grinding proof is one of the key techniques that the production enterprises as well as the machining and manufacturing of the following industries sought to resolve for a long time: plastics, papermaking, rubber, film, and chip production. In Oct. 1984, a new comprehensive machining technique of metal brush coating, grinding with abrasive belt, as well as buffing was used to conduct nearly 20 experiments. In Jan. 1985, a pair of middle convex high precision mirror surface press rollers was successfully machined. The technical process is described.

  16. Rapid consolidation of powdered materials by induction hot pressing.

    PubMed

    LaLonde, Aaron D; Ikeda, Teruyuki; Snyder, G Jeffrey

    2011-02-01

    A rapid hot press system in which the heat is supplied by RF induction to rapidly consolidate thermoelectric materials is described. Use of RF induction heating enables rapid heating and consolidation of powdered materials over a wide temperature range. Such rapid consolidation in nanomaterials is typically performed by spark plasma sintering (SPS) which can be much more expensive. Details of the system design, instrumentation, and performance using a thermoelectric material as an example are reported. The Seebeck coefficient, electrical resistivity, and thermal diffusivity of thermoelectric PbTe material pressed at an optimized temperature and time in this system are shown to agree with material consolidated under typical consolidation parameters. PMID:21361630

  17. Rapid consolidation of powdered materials by induction hot pressing

    NASA Astrophysics Data System (ADS)

    LaLonde, Aaron D.; Ikeda, Teruyuki; Snyder, G. Jeffrey

    2011-02-01

    A rapid hot press system in which the heat is supplied by RF induction to rapidly consolidate thermoelectric materials is described. Use of RF induction heating enables rapid heating and consolidation of powdered materials over a wide temperature range. Such rapid consolidation in nanomaterials is typically performed by spark plasma sintering (SPS) which can be much more expensive. Details of the system design, instrumentation, and performance using a thermoelectric material as an example are reported. The Seebeck coefficient, electrical resistivity, and thermal diffusivity of thermoelectric PbTe material pressed at an optimized temperature and time in this system are shown to agree with material consolidated under typical consolidation parameters.

  18. 25. Paper ready for the calender presses. This picture shows ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    25. Paper ready for the calender presses. This picture shows the paper after it has been coated and dried, as shown on page 238, and it being rolled at the end of the coating-machine. It is now ready to be sent to the big presses which calender it (or iron it, as popular pariance would have it). The pictures on pages 238 and 239 show a continuous process over a single machine; but on account of the length of teh machine, the process is illustrated in sections. (p.239.) - Champion-International Paper Company, West bank of Spicket River at Canal Street, Lawrence, Essex County, MA

  19. Spatial distribution and compositional variation of APS minerals related to uranium deposits in the Kiggavik-Andrew Lake structural trend, Nunavut, Canada

    NASA Astrophysics Data System (ADS)

    Riegler, Thomas; Quirt, Dave; Beaufort, Daniel

    2016-02-01

    The Kiggavik-Andrew Lake structural trend consists of four mineralized zones, partially outcropping, lying 2 km south of the erosional contact with the unmetamorphosed sandstone and basal conglomerates of the Paleoproterozoic Thelon Formation. The mineralization is controlled by a major E-W fault system associated with illite and sudoite alteration halos developed in the Archean metagraywackes of the Woodburn Lake Group. Aluminum phosphate sulfate (APS) minerals from the alunite group crystallized in association with the clay minerals in the basement alteration halo as well as in the overlying sandstones, which underwent mostly diagenesis. APS minerals are Sr- and S-rich (svanbergite end-member) in the sedimentary cover overlying the unconformity, whereas they are light rare earth elements (LREE)-rich (florencite end-member) in the altered basement rocks below the unconformity. The geochemical signature of each group of APS minerals together with the petrography indicates three distinct generations of APS minerals related to the following: (1) paleoweathering of continental surfaces prior to the basin occurrence, (2) diagenetic processes during the burial history of the lower unit of the Thelon sandstones, and (3) hydrothermal alteration processes which accompanied the uranium deposition in the basement rocks and partially overlap the sedimentary-diagenetic mineral parageneses. In addition, the association of a first generation of APS minerals with both detrital cerium oxide and aluminum oxy-hydroxide highlights the fact that a part of the detrital material of the basal Thelon Formation originated from eroded paleolaterite (allochthonous regolith). The primary rare earth element (REE)-bearing minerals (e.g., monazite, REE carbonates, and allanite) of the host rocks were characterized to identify the potential sources of REE. The REE chemical composition highlights a local re-incorporation of the REE released from the alteration processes in the APS minerals of hydrothermal origin. The distinctive geochemical signatures between diagenetic (or sedimentary) and hydrothermal APS minerals suggest a different source material in the Thelon basin than in the Athabasca basin.

  20. Spatial distribution and compositional variation of APS minerals related to uranium deposits in the Kiggavik-Andrew Lake structural trend, Nunavut, Canada

    NASA Astrophysics Data System (ADS)

    Riegler, Thomas; Quirt, Dave; Beaufort, Daniel

    2015-07-01

    The Kiggavik-Andrew Lake structural trend consists of four mineralized zones, partially outcropping, lying 2 km south of the erosional contact with the unmetamorphosed sandstone and basal conglomerates of the Paleoproterozoic Thelon Formation. The mineralization is controlled by a major E-W fault system associated with illite and sudoite alteration halos developed in the Archean metagraywackes of the Woodburn Lake Group. Aluminum phosphate sulfate (APS) minerals from the alunite group crystallized in association with the clay minerals in the basement alteration halo as well as in the overlying sandstones, which underwent mostly diagenesis. APS minerals are Sr- and S-rich (svanbergite end-member) in the sedimentary cover overlying the unconformity, whereas they are light rare earth elements (LREE)-rich (florencite end-member) in the altered basement rocks below the unconformity. The geochemical signature of each group of APS minerals together with the petrography indicates three distinct generations of APS minerals related to the following: (1) paleoweathering of continental surfaces prior to the basin occurrence, (2) diagenetic processes during the burial history of the lower unit of the Thelon sandstones, and (3) hydrothermal alteration processes which accompanied the uranium deposition in the basement rocks and partially overlap the sedimentary-diagenetic mineral parageneses. In addition, the association of a first generation of APS minerals with both detrital cerium oxide and aluminum oxy-hydroxide highlights the fact that a part of the detrital material of the basal Thelon Formation originated from eroded paleolaterite (allochthonous regolith). The primary rare earth element (REE)-bearing minerals (e.g., monazite, REE carbonates, and allanite) of the host rocks were characterized to identify the potential sources of REE. The REE chemical composition highlights a local re-incorporation of the REE released from the alteration processes in the APS minerals of hydrothermal origin. The distinctive geochemical signatures between diagenetic (or sedimentary) and hydrothermal APS minerals suggest a different source material in the Thelon basin than in the Athabasca basin.

  1. STS-26 Preflight Press Briefing: Crew Escape/Crew Equipment. Part 4 of 9

    NASA Technical Reports Server (NTRS)

    1988-01-01

    This NASA KSC video release presents part of a press conference held prior to Discovery flight STS-26, the first shuttle mission flown following the 51-L Challenger accident. The five member panel present individual viewgraph discussions followed by a question and answer period for the benefit of scientific journalists. William A. Chandler (Asst. to the Dir. of Engineering and the NSTS program) gives a brief overview of the crew escape system followed by Steven Nagel's (Astronaut) presentation on crew equipment. Robert Rice (Crew Escape System Manager) describes the flight test program and the innovative pyrotechnics system test program. Tim Pelischek (Pole Design Team) gives an assessment of the critical design review and Ricardo Machin reviews aerodynamic flight tests performed at Texas A&M and California. The second part of the video includes Robert Crippen's (Deputy Dir. of Operations, Kennedy Space Center) overview of NASA Management, the organizational changes and actions taken to meet the Roger's Commission recommendations.

  2. STS-26 Preflight Press Briefing: 5 Man Crew. Part 6 of 9

    NASA Technical Reports Server (NTRS)

    1988-01-01

    This NASA KSC video release presents part of a press conference held prior to Discovery flight STS-26, the first shuttle mission flown following the 51-L Challenger accident. The video opens with a statement from Commander Frederick H. Hauck, and the introductions of crew members, Richard O. Covey, Pilot, and mission specialists, John M. Lounge, George D. Nelson, and David C. Hilmers. Some of the questions posed by scientific journalists addressed the following subjects: launch preparation in the month prior to flight, astronaut family anxieties in light of the Challenger accident, extent of safety measures made prior to flight, flight readiness firing, the crew escape system, civilians in space, conservative mission design, astronaut selection, mission turnaround and launch rate, and the ability to maintain a high level of scrutiny regarding safety on future missions.

  3. STS-26 Preflight Press Briefing: Shuttle Systems Changes (2). Part 3 of 9

    NASA Technical Reports Server (NTRS)

    1988-01-01

    This NASA KSC video release presents part of a press conference held prior to Discovery flight STS-26, the first shuttle mission flown following the 51-L Challenger accident. The video includes presentations by Gerald Smith (Solid Rocket Booster (SRB) Project Manager) and Joe Lombardo (Space Shuttle Main Engine (SSME) Project Manager) discussing the major changes that were made to the SRB and SSME between 51-L and STS-26. Mr. Smith's talk centered on the changes and redesigns made to the solid rocket motor field joint, the case to nozzle joint, the SRB aft skirt, and the ET aft attach ring. Mr. Lombardo discusses test data evaluation, SSME inspections and the SSME heat exchanger in particular.

  4. The effects of androgen deprivation therapy with weight management on serum aP2 and adiponectin levels in prostate cancer patients.

    PubMed

    Urushima, Hayato; Inomata-Kurashiki, Yukiko; Nishimura, Kazuo; Sumi, Ryoko; Shimomura, Iichiro; Nonomura, Norio; Ito, Toshinori; Maeda, Kazuhisa

    2015-06-01

    Androgen deprivation therapy (ADT) for the treatment of prostate cancer (PCa) causes an increase in total body fat, leading to a net gain in body weight. Moreover, the use of the luteinizing hormone-releasing hormone agonists in ADT causes a decrease in serum androgen levels, leading to the development of metabolic syndrome (MetS). Androgen blockade significantly increases plasma adiponectin levels, which has some efficacy against MetS, whereas ADT increases fasting plasma insulin and decreases insulin sensitivity, suggesting that there are other mechanisms involved in the onset of MetS besides adiponectin activation. We investigated the effects of ADT on serum aP2 and adiponectin in PCa patients. Six months post-ADT, serum aP2 and adiponectin levels were significantly increased, although there were no changes in patient body weight and no correlation between the changes in serum aP2 and total adiponectin levels. The serum adiponectin and aP2 levels have independent implications in ADT for PCa; therefore, their combined measurement will clarify the impact on the development of obesity-related diseases during ADT. Contrary to adiponectin, high serum aP2 levels were correlated with the late development of MetS. Further studies are needed to investigate the future occurrence of metabolic diseases post-ADT. PMID:25746209

  5. Integrating Particulate Representations into AP Chemistry and Introductory Chemistry Courses

    ERIC Educational Resources Information Center

    Prilliman, Stephen G.

    2014-01-01

    The College Board's recently revised curriculum for advanced placement (AP) chemistry places a strong emphasis on conceptual understanding, including representations of particle phenomena. This change in emphasis is informed by years of research showing that students could perform algorithmic calculations but not explain those calculations…

  6. 76 FR 82079 - AP1000 Design Certification Amendment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-30

    ... System (CCWS). Changes to I&C Systems. Changes to the Passive Core Cooling System (PCCS)--Gas Intrusion... System (ADAMS): Publicly available documents created or received at the NRC are available online in the... any person. The NRC originally approved the AP1000 design certification in a final rule in 2006 (71...

  7. Approximate entropy (ApEn) as a complexity measure

    NASA Astrophysics Data System (ADS)

    Pincus, Steve

    1995-03-01

    Approximate entropy (ApEn) is a recently developed statistic quantifying regularity and complexity, which appears to have potential application to a wide variety of relatively short (greater than 100 points) and noisy time-series data. The development of ApEn was motivated by data length constraints commonly encountered, e.g., in heart rate, EEG, and endocrine hormone secretion data sets. We describe ApEn implementation and interpretation, indicating its utility to distinguish correlated stochastic processes, and composite deterministic/ stochastic models. We discuss the key technical idea that motivates ApEn, that one need not fully reconstruct an attractor to discriminate in a statistically valid manner—marginal probability distributions often suffice for this purpose. Finally, we discuss why algorithms to compute, e.g., correlation dimension and the Kolmogorov-Sinai (KS) entropy, often work well for true dynamical systems, yet sometimes operationally confound for general models, with the aid of visual representations of reconstructed dynamics for two contrasting processes.

  8. Automated Procurement System (APS) revised project management plan (DS-03)

    NASA Technical Reports Server (NTRS)

    Murphy, Diane R.

    1995-01-01

    The Project Plan is the governing document for the implementation of the Automated Procurement System (APS). It includes a description of the proposed system, describes the work to be done, establishes a schedule of deliverables, and discusses the major standards and procedures to be followed.

  9. The New AP Chemistry Exam: Its Rationale, Content, and Scoring

    ERIC Educational Resources Information Center

    Price, Paul D.; Kugel, Roger W.

    2014-01-01

    The 2013-2014 academic year marks the rollout of the redesigned advanced placement (AP) chemistry course and exam. There have been many questions as to why the course was redesigned and how the new examination will differ from its legacy version. In this article we give a brief overview of the legacy course and examine why a redesign occurred in…

  10. Tead and AP1 coordinate transcription and motility

    PubMed Central

    Liu, Xiangfan; Li, Huapeng; Rajurkar, Mihir; Li, Qi; Cotton, Jennifer L.; Ou, Jianhong; Zhu, Lihua J.; Goel, Hira L.; Mercurio, Arthur M.; Park, Joo-Seop; Davis, Roger J.; Mao, Junhao

    2016-01-01

    SUMMARY The Tead family transcription factors are the major intracellular mediators of the Hippo-Yap pathway. Despite the importance of Hippo signaling in tumorigenesis, Tead-dependent downstream oncogenic programs and target genes in cancer cells remain poorly understood. Here we characterize Tead4-mediated transcriptional networks in a diverse range of cancer cells, including neuroblastoma, colorectal, lung, and endometrial carcinomas. By intersecting genome-wide chromatin occupancy analyses of Tead4, JunD and Fra1/2, we find that Tead4 cooperates with AP1 transcription factors to coordinate target gene transcription. We find that Tead-AP1 interaction is JNK independent, but engages the SRC1-3 coactivators to promote downstream transcription. Furthermore we show that Tead-AP1 cooperation regulates the activity of the Dock-Rac/CDC42 module and drives the expression of a unique core set of target genes, thereby directing cell migration and invasion. Together, our data unveil a critical regulatory mechanism underlying Tead- and AP1-controlled transcriptional and functional outputs in cancer cells. PMID:26832411

  11. ACTIVATION OF AP-1 IN UROTSA CELLS BY METHYLATED ARSENICALS

    EPA Science Inventory

    ACTIVATION OF AP-1 IN UROTSA CELLS BY METHYLATED TRIVALENT ARSENICALS. Z Drobna1, I Jaspers2, D J Thomas3 and M Styblo1. 1Department of Pediatrics; 2Center for Environmental Medicine and Lung Biology, University of North Carolina at Chapel Hill, NC, USA; 3US EPA, RTP, NC, USA.

  12. The APS Panel on Public Affairs and Federal Science Policy

    NASA Astrophysics Data System (ADS)

    Jaffe, Robert

    2013-03-01

    The Panel on Public Affairs (POPA) is the organ through which the APS seeks to provide high quality input to the Federal Government on issues with significant physics content, ranging from energy and environment to national security. I will describe POPA's evolving mission, some recent efforts and successes, and look at the agenda for the next few years.

  13. Time Trials--An AP Physics Challenge Lab

    ERIC Educational Resources Information Center

    Jones, David

    2009-01-01

    I have come to the conclusion that for high school physics classroom and laboratory experiences, simpler is better! In this paper I describe a very simple and effective lab experience that my AP students have thoroughly enjoyed year after year. I call this lab exercise "Time Trials." The experiment is simple in design and it is a lot of fun for…

  14. APS storage ring vacuum chamber: Section 1, Evaluation

    SciTech Connect

    Benaroya, R.; Roop, B.

    1995-07-01

    The vacuum characteristics of the APS storage ring vacuum chamber prototype, Section One (S1), is presented. The base pressure achieved was 4 {times} 10{sup {minus}11}, the welds contained no virtual or real leaks, the NeG strip mounting design and activation procedures have been determined, and S1 was found contaminated with hydrocarbons.

  15. Integrating Particulate Representations into AP Chemistry and Introductory Chemistry Courses

    ERIC Educational Resources Information Center

    Prilliman, Stephen G.

    2014-01-01

    The College Board's recently revised curriculum for advanced placement (AP) chemistry places a strong emphasis on conceptual understanding, including representations of particle phenomena. This change in emphasis is informed by years of research showing that students could perform algorithmic calculations but not explain those calculations

  16. The AP Lever for Boosting Access, Success, and Equity

    ERIC Educational Resources Information Center

    Roegman, Rachel; Hatch, Thomas

    2016-01-01

    Four New Jersey school districts worked together to increase student achievement by applying a number of strategies focused on getting traditionally underrepresented students to take more AP courses. The districts are members of the New Jersey Network of Superintendents (NJNS), comprising 15 superintendents who work together to develop systemwide…

  17. 75 FR 75666 - Advanced Placement (AP) Test Fee Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-06

    ...: On September 1, 2010, we published in the Federal Register (75 FR 53681) a notice inviting... in the September 1, 2010 notice (75 FR 53682-53683). We encourage eligible applicants to submit their... Advanced Placement (AP) Test Fee Program AGENCY: Office of Elementary and Secondary Education...

  18. CMOS APS imaging system application in star tracker

    NASA Astrophysics Data System (ADS)

    Li, Jie; Liu, Jinguo; Li, Xuekui; Liu, Yaxia; Hao, Zhihang

    2005-01-01

    Small satellites are capable of performing space explore missions that require accurate attitude determination and control. However, low weight, size, power and cost requirements limit the types of attitude sensor of small craft, such as CCD, are not practical for small satellites. CMOS APS is a good substitute for attitude sensors of small craft. Some of the technical advantages of CMOS APS are no blooming, single power, low power consumption, small size and little support circuitry, direct digital output, simple to system design, in particular, radiation-hard characteristic compare with CCD. This paper discusses the application probability of CMOS APS in star tracker for small satellites, further more, a prototype ground-based star camera based on STAR250 CMOS image sensor has been built. In order to extract stars positions coordinates, subpixel accuracy centroiding algorithm has been developed and tested on some ground-based images. Moreover, the camera system star sensitivity and noise model are analyzed, and the system accuracy is been evaluated. Experimental results indicate that a star camera based on CMOS APS is a viable practical attitude sensor appropriate for space small satellites.

  19. A Web Site Supporting the AP Descriptive Chemistry Question

    NASA Astrophysics Data System (ADS)

    Crippen, Kent J.; Brooks, David W.; Abuloum, Amjad

    2000-08-01

    This paper describes the use of a Web page that generates and grades quizzes based on the descriptive AP exam question, in a manner historically similar to previous pencil-and-paper exams. Use of the site indicates a potential as an educational tool. The intent of this article is to describe to interested chemistry teachers early use of this chemistry teaching Web site.

  20. Tank 241-AP-106 tank characterization plan: Revision 1

    SciTech Connect

    Valenzuela, B.D.

    1994-11-17

    Tank 241-AP-106 (AP-106) is a candidate feed tank which is expected to be processed at the 242-A Evaporator. Three issues related to the overall concern of the evaporator must be evaluated: compatibility of the candidate waste with respect to feed tank, slurry tank, and evaporator requirements; safety parameters of the candidate waste tank to avoid a facility condition which is outside the safety boundaries; and compliance of the waste as dictated by regulations from various government and environmental agencies. The characterization efforts of this Tank Characterization Plan are focused on the resolution of the issues above. To evaluate the potential for waste incompatibility with the feed tank, slurry tank, and evaporator, as well as relevant safety issues, analyses will be performed on the grab samples obtained from tank AP-106. These analyses are discussed in Section 4.0. Once the characterization of tank AP-106 has been performed, the waste compatibility and safety assessment shall be conducted. This effort is discussed elsewhere.

  1. Nuclear Reactor Safety--The APS Submits its Report

    ERIC Educational Resources Information Center

    Physics Today, 1975

    1975-01-01

    Presents the summary section of the American Physical Society (APS) report on the safety features of the light-water reactor, reviews the design, construction, and operation of a reactor and outlines the primary engineered safety features. Summarizes the major recommendations of the study group. (GS)

  2. AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast.

    PubMed

    Kirchhausen, T; Davis, A C; Frucht, S; Greco, B O; Payne, G S; Tubb, B

    1991-06-15

    AP17 and AP19 are the smallest polypeptide chain components of AP-2 and AP-1, the clathrin-associated protein complexes found in coated structures of the plasma membrane and Golgi apparatus of mammalian cells. cDNA clones representing the entire coding sequence of AP17 and AP19 were isolated from rat and mouse brain cDNA libraries, respectively. Determination of their nucleotide sequence predicts proteins of 142 and 158 amino acids with Mr 17,018 and 18,733. A sequence comparison of rat brain AP17 with mouse brain AP19 demonstrates that the small chains are highly related. A computer search for other related proteins has uncovered in yeast a previously unknown gene whose DNA sequence encodes a protein homologous to the small chain of AP complexes. The yeast sequence predicts Yap17p, a protein with 147 amino acids and a Mr of 17,373 that is slightly more related to the mammalian AP17 chain than to its AP19 counterpart. PMID:2040623

  3. Nucleolin binds specifically to an AP-1 DNA sequence and represses AP1-dependent transactivation of the matrix metalloproteinase-13 gene.

    PubMed

    Samuel, Shaija; Twizere, Jean-Claude; Beifuss, Katherine K; Bernstein, Lori R

    2008-01-01

    Transcriptional regulation via activator protein-1 (AP-1) protein binding to AP-1 binding sites within gene promoter regions of AP-1 target genes plays a key role in controlling cellular invasion, proliferation, and oncogenesis, and is important to pathogenesis of arthritis and cardiovascular disease. To identify new proteins that interact with the AP-1 DNA binding site, we performed the DNA affinity chromatography-based Nucleotide Affinity Preincubation Specificity TEst of Recognition (NAPSTER) assay, and discovered a 97 kDa protein that binds in vitro to a minimal AP-1 DNA sequence element. Mass spectrometric fragmentation sequencing determined that p97 is nucleolin. Immunoblotting of DNA affinity-purified material with anti-nucleolin antibodies confirmed this identification. Nucleolin also binds the AP-1 site in gel shift assays. Nucleolin interacts in NAPSTER with the AP-1 site within the promoter sequence of the metalloproteinase-13 gene (MMP-13), and binds in vivo in chromatin immunoprecipitation assays in the vicinity of the AP-1 site in the MMP-13 promoter. Overexpression of nucleolin in human HeLa cervical carcinoma cells significantly represses AP-1 dependent gene transactivation of a minimal AP-1 reporter construct and of an MMP-13 promoter reporter sequence. This is the first report of nucleolin binding and transregulation at the AP-1 site. PMID:17626252

  4. The 50 kDa protein subunit of assembly polypeptide (AP) AP-2 adaptor from clathrin-coated vesicles is phosphorylated on threonine-156 by AP-1 and a soluble AP50 kinase which co-purifies with the assembly polypeptides.

    PubMed Central

    Pauloin, A; Thurieau, C

    1993-01-01

    AP50 is a subunit of the assembly polypeptide (AP) subclass AP-2 from bovine brain coated vesicles. It can be phosphorylated in vivo and in vitro on a threonine residue by means of the AP50 kinase activity associated with AP. We have undertaken an analysis of the amino acid sequence around the AP50 phosphorylation site. After phosphorylation in vitro of AP50 followed by tryptic cleavage, only one radioactive peptide was isolated following Mono-Q ion-exchange f.p.l.c. and reverse-phase h.p.l.c. The amino acid sequence of this peptide: Glu146-Glu-Gln-Ser-Gln-Ile-Thr-Ser-Gln-Val-Thr*-Gly-Gly-Ile-Gly-Tr p-Arg162, displayed two threonine residues. Analysis of the yield and radioactivity of the product from automated Edman degradation indicated that only Thr-156 was phosphorylated, reflecting the presence of a single phosphorylation site in AP50. AP phosphorylated the corresponding synthetic peptide on the same threonyl residue. We demonstrated that AP50 was a phosphorylation substrate unable to autophosphorylate. The enzyme involved in the AP50 phosphorylation was shown to be associated with AP-1 and with a soluble protein complex co-purified with APs but resolved from the latter by hydroxyapatite-column exclusion chromatography. This AP50 kinase activity corresponded to a 280 kDa protein complex according to gel-filtration data. Images Figure 1 Figure 2 Figure 4 Figure 5 Figure 6 Figure 7 PMID:8257432

  5. Hot-pressed Sm2Fe17Nx/Fe-Co composites: Factors controlling densification and in situ nitrogenization of Sm2Fe17 phase

    NASA Astrophysics Data System (ADS)

    Gabay, A. M.; Akdogan, N. G.; Hadjipanayis, G. C.; Marinescu, M.; Liu, J. F.; Ali, A.

    2008-04-01

    The effects of powder preparation and conditions of hot pressing on the structure and density of consolidated Sm2Fe17Nx and Sm2Fe17Nx/Fe-Co magnets have been studied. Densities achieved in the case of Sm2Fe17Nx powders prepared through a low-energy milling were higher than after a high-energy milling. The difference is mostly caused by the different particle size, and it can be eliminated by an additional low-energy milling of the coarse high-energy milled powder. The presence of a ductile soft magnetic phase greatly facilitates densification, leading to considerably higher absolute and relative densities in hot-pressed Sm2Fe17Nx/Fe0.65Co0.35 composites. We have found that during hot pressing, nitrogenization of the Sm2Fe17 phase may occur in situ if pressed together with Fe-Co-N powders. Because Fe-Co-N releases nitrogen below the decomposition temperature of Sm2Fe17Nx, we were able to fabricate the Sm2Fe17Nx/Fe0.65Co0.35 composite with the density up to 7.6g/cm3 by hot-pressing mixtures of Sm2Fe17 and (Fe0.65Co0.35)89N11 powders.

  6. Copper corrosion & clogging in APS deionized water cooling system

    NASA Astrophysics Data System (ADS)

    Adak, Bijaya

    An extensive amount of work has been performed on copper corrosion in last century due to its abundant use in domestic and industrial water systems. However, work on copper corrosion in deionized water is very limited. The water cooling system of Advanced Photon Source (APS) at Argonne National Laboratory uses deionized water containing very low dissolved oxygen (less than 10 ppb). Therefore, It is expected that copper corrosion would be less in this system. On the contrary, APS suffers significant clogging in its water cooling circuit resulting from the deposition of corrosion product and carries out frequent expensive maintenance to retain the required flow rate. The location of pH and corrosion potential of APS water cooling system is very close to the boundary condition of the two oxides (CuO and Cu 2O) of the Pourbaix diagram of copper. While a single phase presence of either of these two oxides is stable as a protective layer, a mixture of the two oxides is unstable. An unstable protective layer results in spalling of the oxide layer. A fluctuation in water chemistry (which is common in an industrial facility) triggers a phase transformation between these two oxides due to its near boundary values. It was observed that the location of pH and corrosion potential was away from the boundaries in high dissolved oxygen condition (more than 2000 ppm). Hence, the possibility of phase transformation becomes lesser in high dissolved oxygen condition than in low dissolved oxygen condition. A test station, that was a replica of the APS water cooling system, was used to perform experiments in both high and low oxygen condition. It was demonstrated that high oxygen condition results in less clogging than in low oxygen condition. Microstructural characterization was performed on the coupons from test station and on some components from APS to evaluate oxide surface and determine phases. Mechanism of the phase transformation was suggested.

  7. The AP2-Like Gene OitaAP2 Is Alternatively Spliced and Differentially Expressed in Inflorescence and Vegetative Tissues of the Orchid Orchis italica

    PubMed Central

    Salemme, Marinella; Sica, Maria; Iazzetti, Giovanni; Gaudio, Luciano; Aceto, Serena

    2013-01-01

    The AP2/ERF proteins are plant-specific transcription factors involved in multiple regulatory pathways, from plant organ development to response to various environmental stresses. One of the mechanisms that regulates the AP2-like genes involves the microRNA miR172, which controls their activity at the post-transcriptional level. Extensive studies on AP2-like genes are available in many different species; however, in orchids, one of the largest plant families, studies are restricted to a few species, all belonging to the Epidendroideae subfamily. In the present study, we report the isolation of an AP2-like gene in the Mediterranean orchid Orchis italica (Orchidoideae). The OitaAP2 locus includes 10 exons and 9 introns, and its transcript is alternatively spliced, resulting in the long OitaAP2 and the short OitaAP2_ISO isoforms, with the latter skipping exon 9. Both isoforms contain the conserved target site for miR172, whose action is demonstrated by the presence of cleaved OitaAP2 mRNA. The OitaAP2 and OitaAP2_ISO mRNAs are present in the tepals and lip before and after anthesis at different expression levels. In addition, the OitaAP2_ISO isoform is expressed in the ovary before pollination and in the root and stem. The isoform-specific expression pattern suggests a functional differentiation of the OitaAP2 alternatively spliced transcripts. The expression profile of miR172 is complementary to that of the OitaAP2 isoforms in inflorescence tissues before anthesis, whereas after anthesis and in ovary tissue before and after pollination, this relationship disappears, suggesting the existence of OitaAP2 inhibitory mechanisms in these tissues that differ from that involving miR172. PMID:24204832

  8. Calcyon, a mammalian specific NEEP21 family member, interacts with adaptor protein complex 3 (AP-3) and regulates targeting of AP-3 cargoes.

    PubMed

    Muthusamy, Nagendran; Faundez, Victor; Bergson, Clare

    2012-10-01

    Calcyon is a neural enriched, single transmembrane protein that interacts with clathrin light chain and stimulates clathrin assembly and clathrin-mediated endocytosis. A similar property is shared by the heterotetrameric adaptor protein (AP) complexes AP-1, AP-2, and AP-3 which recruit cargoes for insertion into clathrin coated transport vesicles. Here we report that AP medium (μ) subunits interact with a YXXØ-type tyrosine motif located at residues 133-136 in the cytoplasmic domain of calcyon. Site specific mutagenesis of the critical tyrosine and bulky hydrophobic residues tyrosine 133 and methionine 136 preferentially abrogated binding of the ubiquitous and neuronal isoforms of μ3, and also impacted μ1 and μ2 binding to a lesser degree. The relevance of these interactions was explored in vivo using mice harboring null alleles of calcyon. As seen in the mutagenesis studies, calcyon deletion in mice preferentially altered the subcellular distribution of AP-3 suggesting that calcyon could regulate membrane-bound pools of AP-3 and AP-3 function. To test this hypothesis, we focused on the hilar region of hippocampus, where levels of calcyon, AP-3, and AP-3 cargoes are abundant. We analyzed brain cryosections from control and calcyon null mice for zinc transporter 3 (ZnT3), and phosphatidylinositol-4-kinase type II alpha (PI4KIIα), two well-defined AP-3 cargoes. Confocal microscopy indicated that ZnT3 and PI4KIIα are significantly reduced in the hippocampal mossy fibers of calcyon knock-out brain, a phenotype previously described in AP-3 deficiencies. Altogether, our data suggest that calcyon directly interacts with μ3A and μ3B, and regulates the subcellular distribution of AP-3 and the targeting of AP-3 cargoes. PMID:22650988

  9. Molecular and biochemical characterisation of two aspartic proteinases TcAP1 and TcAP2 from Theobroma cacao seeds.

    PubMed

    Laloi, Maryse; McCarthy, James; Morandi, Olivia; Gysler, Christof; Bucheli, Peter

    2002-09-01

    Aspartic proteinase (EC 3.4.23) activity plays a pivotal role in the degradation of Theobroma cacao L. seed proteins during the fermentation step of cacao bean processing. Therefore, this enzyme is believed to be critical for the formation of the peptide and amino acid cocoa flavor precursors that occurs during fermentation. Using cDNA cloning and northern blot analysis, we show here that there are at least two distinct aspartic proteinase genes ( TcAP1 and TcAP2) expressed during cacao seed development. Both genes are expressed early during seed development and their mRNA levels decrease towards the end of seed maturation. TcAP2 is expressed at a much higher level than TcAP1, although the expression of TcAP1 increases slightly during germination. The proteins encoded by TcAP1 and TcAP2 are relatively different from each other (73% identity). This, and the fact that the two corresponding genes have different expression patterns, suggests that the TcAP1 and TcAP2 proteins may have different functions in the maturing seeds and during germination. Because the TcAP2 gene is expressed at a much higher level during seed development than TcAP1, it is likely that the TcAP2 protein is primarily responsible for the majority of the industrially important protein hydrolysis that occurs during cacao bean fermentation. Finally, TcAP2 has been functionally expressed in the yeast Yarrowia lipolytica. The secreted recombinant protein is able to hydrolyse bovine haemoglobin at acidic pH and is sensitive to pepstatin A, confirming that TcAP2 encodes an aspartic proteinase, and strongly suggests that this gene encodes the well-characterized aspartic proteinase of mature cacao seeds. PMID:12244440

  10. Toward a Normative Theory of Freedom of the Press.

    ERIC Educational Resources Information Center

    Jensen, Dwight Wm.

    In considering the possibility of a normative theory of freedom of the press, this paper examines arguments about such freedom in the Third World and elsewhere. Some of the arguments discussed in the paper are derived from the theories of John Locke and Karl Marx; others are drawn from the concepts of divine rights, elitism, liberal democracy, and…

  11. Apollo 9 prime crew participates in press conference at MSC

    NASA Technical Reports Server (NTRS)

    1969-01-01

    The Apollo 9 prime crew participates in a press conference in bldg 1 at the Manned Spacecraft Center (MSC). Left to right, are Astronauts Russell L. Schweickart, lunar module pilot; James A. McDivitt, commander; and David R. Scott, command module pilot.

  12. Apollo 10 post flight press conference at MSC

    NASA Technical Reports Server (NTRS)

    1969-01-01

    Apollo 10 post flight press conference at held at the Manned Spacecraft Center (MSC) on June 7, 1969. Seated at the table are (l-r) Thomas P. Stafford, John W. Young, and Eugene A. Cernan, the Apollo 10 prime crew.

  13. Illinois Occupational Skill Standards: Imaging/Pre-Press Cluster.

    ERIC Educational Resources Information Center

    Illinois Occupational Skill Standards and Credentialing Council, Carbondale.

    This document, which is intended as a guide for work force preparation program providers, details the Illinois occupational skill standards for programs preparing students for employment in occupations in the imaging/pre-press cluster. The document begins with a brief overview of the Illinois perspective on occupational skill standards and…

  14. The Press of the Soviet Union: A Bibliography.

    ERIC Educational Resources Information Center

    Bergethon, Bruce; And Others

    Compiled in response to the need for more information on the differences between the press systems of the United States and the Soviet Union, this bibliography contains 240 entries. Consisting of newspaper articles, journal articles, books, and pamphlets, the bibliography provides an overview of the different journalistic philosophies of the two…

  15. Democratic Socialism: Toward a Fifth Theory of the Press.

    ERIC Educational Resources Information Center

    Picard, Robert G.

    For more than 25 years, the "four theories" paradigm has been dominant in the study of the relationships among the press, society, and the state. Asserting that the major approaches to such study are the libertarian, social responsibility, authoritarian, and Soviet/communist theories, this paradigm fails to account for economic and social…

  16. Argonne Director Eric Isaacs addresses the National Press Club

    SciTech Connect

    Eric Isaccs

    2009-09-17

    Argonne Director Eric Isaacs addresses the National Press Club on 9/15/2009. To build a national economy based on sustainable energy, the nation must first "reignite its innovation ecology," he said. Issacs makes the case for investing in science to secure America's future.

  17. Selected Perspectives on Legal Problems of the Alternative Press.

    ERIC Educational Resources Information Center

    De Mott, John

    The legal problems faced by publishers of alternative newspapers are often compounded by the limited availability of the funds they have either for legal defense or for initiating lawsuits. Although both the courts and journalism's professional associations theoretically support the position that the alternative press possesses rights identical to…

  18. The Mutilated Boy and the Press: A Rumor Study.

    ERIC Educational Resources Information Center

    Brown, Lee

    Responsible editors avoid printing falsehoods, but the public sometimes demands that rumors be covered in the press. One example of such rumors and the way editors deal with them is the "Mutilated Boy." The "Mutilated Boy" rumor has been circulating for decades and involves a brutal attack upon a small boy in a public rest room. The "crime" is…

  19. Pressing for Elaboration in Student Talk about Texts

    ERIC Educational Resources Information Center

    McElhone, D.

    2013-01-01

    This article explores the practice of one accomplished teacher who uses follow-up probes to press her fourth- and fifth-grade students to clarify and articulate their ideas more fully. Qualitative analysis of field notes, teacher and student interviews, and video recordings of instruction, and discourse analysis of reading conferences revealed…

  20. 29 CFR 1910.217 - Mechanical power presses.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... deenergized. (8) Electrical. (i) A main power disconnect switch capable of being locked only in the Off...) Maintain a certification record of each inspection, and each maintenance and repair task performed, under... before operating the press; and (C) Maintain a certification record of each maintenance task...

  1. Quid Pro Quo: Tobacco Companies and the Black Press

    PubMed Central

    McCandless, Phyra M.; Yerger, Valerie B.

    2012-01-01

    Objectives. We explored the relationship between tobacco companies and the Black press, which plays an important role in conveying information and opinions to Black communities. Methods. In this archival case study, we analyzed data from internal tobacco industry documents and archives of the National Newspaper Publishers Association (NNPA), the trade association of the Black press. Results. In exchange for advertising dollars and other support, the tobacco industry expected and received support from Black newspapers for tobacco industry policy positions. Beginning in the 1990s, resistance from within the Black community and reduced advertising budgets created counterpressures. The tobacco industry, however, continued to sustain NNPA support. Conclusions. The quid pro quo between tobacco companies and the Black press violated journalistic standards and represented an unequal trade. Although numerous factors explain today's tobacco-related health disparities, the Black press's service to tobacco companies is problematic because of the trust that the community placed in such media. Understanding the relationship between the tobacco industry and the NNPA provides insight into strategies that the tobacco industry may use in other communities and countries. PMID:21852652

  2. Looking north at uing press of the submerged arc weld ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Looking north at u-ing press of the submerged arc weld (saw) line of the main pipe mill building, bay 7. - U.S. Steel National Tube Works, Main Pipe Mill Building, Along Monongahela River, McKeesport, Allegheny County, PA

  3. 42. PRESSING A SLAB OF CLAY ONTO A MOSAIC MOLD. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    42. PRESSING A SLAB OF CLAY ONTO A MOSAIC MOLD. THE MOLD, WHICH HAS A RAISED DESIGN, LEAVES AND OUTLINE IN THE SLAB, THE PIECES THUS DEFINED, ARE THEN CUT APART TO BE FIRED SEPARATELY AND REASSEMBLED. - Moravian Pottery & Tile Works, Southwest side of State Route 313 (Swamp Road), Northwest of East Court Street, Doylestown, Bucks County, PA

  4. Argonne Director Eric Isaacs addresses the National Press Club

    ScienceCinema

    Eric Isaccs

    2010-01-08

    Argonne Director Eric Isaacs addresses the National Press Club on 9/15/2009. To build a national economy based on sustainable energy, the nation must first "reignite its innovation ecology," he said. Issacs makes the case for investing in science to secure America's future.

  5. SOURCE ASSESSMENT: PRESSED AND BLOWN GLASS MANUFACTURING PLANTS

    EPA Science Inventory

    This report summarizes the results of a study to gather and analyze background information and technical data related to air emissions from glass manufacturers producing pressed and blown glassware. This includes all glassware except flat glass, glass containers, and fiber glass....

  6. Constitutional Provisions on the Press: A World View.

    ERIC Educational Resources Information Center

    Paraschos, Manny

    A study examined the legal treatment of the press in constitutions or other basic legal institutional documents from around the world. Sixty-three constitutions or basic documents from the Western World, the Communist Bloc, the Middle East, Africa, Southeast Asia, and Latin America were analyzed. Analysis revealed that most constitutions open with

  7. Ethics and the Press: Readings in Mass Media Morality.

    ERIC Educational Resources Information Center

    Merrill, John C., Ed.; Barney, Ralph D., Ed.

    This collection of 35 articles addresses the topic of the ethical considerations and implications involved in reporting the news. Included in this book are such articles as: "Ethics and Journalism" by John Merrill, "Quality in Mass Communications" by Wilbur Schramm, "The American Press: Some Truths About Truths" by Edward Jay Epstein, "The New

  8. University Press Meeting Dominated by Donor Proposal and Digital Publishing

    ERIC Educational Resources Information Center

    Howard, Jennifer

    2007-01-01

    A surprise request for proposals from the Andrew W. Mellon Foundation and a forthcoming report on university publishing in the digital age were among topics discussed at the annual meeting of the Association of American University Presses. The offer from the Mellon Foundation concerns support for collaborative, monograph-centered projects in…

  9. Evaluation of a cone press for forage fractionation

    SciTech Connect

    Straub, R.J.; Koegel, R.G.

    1981-01-01

    A cone or 'Vee' press was evaluated for juice expression from macerated alfalfa. Parameters evaluated were throughput, final moisture content, juice solids content, pressure exerted, and energy required. Independent varibles were rotational speed, compression ratio, packer frequency and force, and initial moisture. Average energy required was 0.95 kWh/t. 9 refs.

  10. Tell Us More: Reading Comprehension, Engagement, and Conceptual Press Discourse

    ERIC Educational Resources Information Center

    McElhone, Dot

    2012-01-01

    This study examines interactions between teachers and students during reading comprehension instruction to determine how certain patterns of teacher-student talk support student comprehension achievement and reading engagement. The central focus of the study is "conceptual press discourse," a pattern of teacher response that includes requests for…

  11. DETAIL VIEW OF FILTER PRESS REMAINS, BOILER, SECONDARY ORE BIN, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    DETAIL VIEW OF FILTER PRESS REMAINS, BOILER, SECONDARY ORE BIN, TRAM TRESTLE AND WATER TANK, LOOKING NORTHWEST. HIS VIEW IS TAKEN FROM THE THIRD LEVEL OF THE MILL, NEARBY THE BLACKSMITH'S FORGE. - Keane Wonder Mine, Park Route 4 (Daylight Pass Cutoff), Death Valley Junction, Inyo County, CA

  12. 18. Interior detail, drill press and grinder, Machine Shop, Roundhouse ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. Interior detail, drill press and grinder, Machine Shop, Roundhouse Machine Shop Extension, Southern Pacific Railroad Carlin Shops, view to east (135mm lens). - Southern Pacific Railroad, Carlin Shops, Roundhouse Machine Shop Extension, Foot of Sixth Street, Carlin, Elko County, NV

  13. 19. Interior detail, grinder and drill press, Machine Shop, Roundhouse ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. Interior detail, grinder and drill press, Machine Shop, Roundhouse Machine Shop Extension, Southern Pacific Railroad Carlin Shops, view to south (135mm lens). - Southern Pacific Railroad, Carlin Shops, Roundhouse Machine Shop Extension, Foot of Sixth Street, Carlin, Elko County, NV

  14. Institutional Stress: Conflicting Normative Models in the Catholic Press.

    ERIC Educational Resources Information Center

    Thorn, William; Garrison, M. Bruce

    To determine whether the diocesan newspapers of the Catholic church are based on an autonomous, adversarial model or on an institutional, public relations model of the press, a survey was conducted of 148 editors and 145 bishops or publishers of such newspapers. Results showed that the editors and bishops agreed on the three major roles of the…

  15. Student Press Freedom: One View of the "Hazelwood" Decision.

    ERIC Educational Resources Information Center

    Goodman, Mark

    1988-01-01

    Reviews the "Hazelwood v. Kuhlmeier" U.S. Supreme Court decision upholding a principal's right to censor the content of a school-sponsored student publication. Explains why teachers oppose this decision, discusses liability issues, and argues for a free, uncensored student press. Includes eight legal references. (MLH)

  16. Toward a Normative Theory of Freedom of the Press.

    ERIC Educational Resources Information Center

    Jensen, Dwight Wm.

    In considering the possibility of a normative theory of freedom of the press, this paper examines arguments about such freedom in the Third World and elsewhere. Some of the arguments discussed in the paper are derived from the theories of John Locke and Karl Marx; others are drawn from the concepts of divine rights, elitism, liberal democracy, and

  17. Extraction of proteins from pennycress seeds and press cake

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In order to more fully utilize pennycress, a potentially viable bio-diesel source, the proteinaceous components were extracted from pennycress seed and press cake. The amino acid composition of the proteins present in pennycress was typical for proteins derived from plants, with glycine, glutamic ac...

  18. Ethics and the Press: Readings in Mass Media Morality.

    ERIC Educational Resources Information Center

    Merrill, John C., Ed.; Barney, Ralph D., Ed.

    This collection of 35 articles addresses the topic of the ethical considerations and implications involved in reporting the news. Included in this book are such articles as: "Ethics and Journalism" by John Merrill, "Quality in Mass Communications" by Wilbur Schramm, "The American Press: Some Truths About Truths" by Edward Jay Epstein, "The New…

  19. Correlates of Texas Standard AP Charter Campuses and How They Compare with Standard AP Traditional Public Campuses

    ERIC Educational Resources Information Center

    Gomez, Jason Diego

    2009-01-01

    The research sought to objectively evaluate the effectiveness of Texas standard AP open-enrollment charter school campuses and to discover independent variables that may be utilized to predict effective charter school campuses. The data items used in the analyses were downloaded from the 2007-2008 Academic Excellence Indicator System (AEIS), which…

  20. Aviation Safety Program: Weather Accident Prevention (WxAP) Development of WxAP System Architecture And Concepts of Operation

    NASA Technical Reports Server (NTRS)

    Grantier, David

    2003-01-01

    This paper presents viewgraphs on the development of the Weather Accident Prevention (WxAP) System architecture and Concept of Operation (CONOPS) activities. The topics include: 1) Background Information on System Architecture/CONOPS Activity; 2) Activity Work in Progress; and 3) Anticipated By-Products.

  1. Association for the Advancement of Mexican Americans (AAMA) Press Conference on the Houston Independent School District (HISD). [Press Materials.

    ERIC Educational Resources Information Center

    Farias, Richard R., Comp.

    This press package provides data about the operations of the Houston Independent School District (HISD). The information is presented to compare test results among schools that are predominately Black, White, and Hispanic. The test results are broken down into three subject areas: reading, math, and writing. Other figures offer information on…

  2. The Suburban Press; First Steps toward an Annotated Bibliography. Suburban Press Research Series No. 16 and 17.

    ERIC Educational Resources Information Center

    Northern Illinois Univ., De Kalb. Suburban Press Research Center.

    This bibliography lists journal articles concerning various aspects of the suburban press. Annotated selections, arranged alphabetically according to journal title, are gathered from the following periodicals: "Advertising Age,""Business Week,""Columbia Journalism Review,""Editor and Publisher,""Grassroots Editor,""Journalism…

  3. Metonymie dans la presse ecrite: entre discours et langue (Metonymies in the Press: Between Discourse and Language).

    ERIC Educational Resources Information Center

    Lecolle, Michelle

    2001-01-01

    This paper describes certain metonymies that are often employed in the daily French press. In such metonymies, a human being or a set of individuals are referred to by means of the name of an institutional location (i.e., a capital city, a ministry in a western country, the name of a country). These metonymic patterns do not seem to be used by…

  4. Coverage of Jamaica in the U.S. and Canadian Press in 1976: A Study of Press Bias and Effect.

    ERIC Educational Resources Information Center

    Cuthbert, Marlene; Sparkes, Vernone

    In 1976, Jamaican government officals claimed that their island had received an especially negative press in the United States during 1975 and 1976 with serious consequences for the economy and tourist trade. This accusation was not made about Canadian coverage, with one major exception, and Canadian tourism to Jamaica increased during those years…

  5. AP4 is required for mitogen- and c-MYC-induced cell cycle progression

    PubMed Central

    Jackstadt, Rene; Hermeking, Heiko

    2014-01-01

    AP4 represents a c-MYC-inducible bHLH-LZ transcription factor, which displays elevated expression in many types of tumors. We found that serum-starved AP4-deficient mouse embryo fibroblasts (MEFs) were unable to resume proliferation and showed a delayed S-phase entry after restimulation. Furthermore, they accumulated as tetraploid cells due to a cytokinesis defect. In addition, AP4 was required for c-MYC-induced cell cycle re-entry. AP4-deficient MEFs displayed decreased expression of CDK2 (cyclin-dependent kinase 2), which we characterized as a conserved and direct AP4 target. Activation of an AP4 estrogen receptor fusion protein (AP4-ER) enhanced proliferation of human diploid fibroblasts in a CDK2-dependent manner. However, in contrast to c-MYC-ER, AP4-ER activation was not sufficient to induce cell cycle re-entry or apoptosis in serum-starved MEFs. AP4-deficiency was accompanied by increased spontaneous and c-MYC-induced DNA damage in MEFs. Furthermore, c-MYC-induced apoptosis was decreased in AP4-deficient MEFs, suggesting that induction of apoptosis by c-MYC is linked to its ability to activate AP4 and thereby cell cycle progression. Taken together, these results indicate that AP4 is a central mediator and coordinator of cell cycle progression in response to mitogenic signals and c-MYC activation. Therefore, inhibition of AP4 function may represent a therapeutic approach to block tumor cell proliferation. PMID:25261373

  6. Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, VCP.

    PubMed

    Druck, T; Gu, Y; Prabhala, G; Cannizzaro, L A; Park, S H; Huebner, K; Keen, J H

    1995-11-01

    Clathrin-coated vesicles, involved in endocytosis and Golgi processing, have a surface lattice containing clathrin triskelia and stoichiometric amounts of additional components termed "assembly proteins," or APs. The AP form at the plasma membrane, AP2, is composed of two large subunits of 100-115 kDa, denoted AP2 alpha and AP2 beta, a medium chain of 50 kDa, designated AP50, and a small chain. We have determined human chromosomal locations of genes for a large AP2 beta (CLAPB1) and a medium (CLAPM1) AP subunit and of a novel clathrin-binding protein, VCP, that binds clathrin simultaneously with APs. Chromosomal in situ hybridization of a human genomic clone demonstrated that the CLAPM1 gene mapped to chromosome region 3q28. The gene for the CLAPB1 large subunit was mapped to 17q11.2-q12 by PCR amplification of an AP2 beta fragment from a panel of rodent-human hybrid DNAs. To map the human VCP sequence, a human-specific probe was made by RT-PCR of human mRNA using oligonucleotide primers from conserved regions of the porcine sequence. The amplified human fragment served as probe on Southern blots of hybrid DNAs to determine that the human VCP locus maps to chromosome region 9pter-q34. PMID:8595912

  7. AP39, A Mitochondrially Targeted Hydrogen Sulfide Donor, Exerts Protective Effects in Renal Epithelial Cells Subjected to Oxidative Stress in Vitro and in Acute Renal Injury in Vivo.

    PubMed

    Ahmad, Akbar; Olah, Gabor; Szczesny, Bartosz; Wood, Mark E; Whiteman, Matthew; Szabo, Csaba

    2016-01-01

    This study evaluated the effects of AP39 [(10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5yl) phenoxy)decyl) triphenyl phosphonium bromide], a mitochondrially targeted donor of hydrogen sulfide (H2S) in an in vitro model of hypoxia/oxidative stress injury in NRK-49F rat kidney epithelial cells (NRK cells) and in a rat model of renal ischemia-reperfusion injury. Renal oxidative stress was induced by the addition of glucose oxidase, which generates hydrogen peroxide in the culture medium at a constant rate. Glucose oxidase (GOx)-induced oxidative stress led to mitochondrial dysfunction, decreased intracellular ATP content, and, at higher concentrations, increased intracellular oxidant formation (estimated by the fluorescent probe 2, 7-dichlorofluorescein, DCF) and promoted necrosis (estimated by the measurement of lactate dehydrogenase release into the medium) of the NRK cells in vitro. Pretreatment with AP39 (30-300 nM) exerted a concentration-dependent protective effect against all of the above effects of GOx. Most of the effects of AP39 followed a bell-shaped concentration-response curve; at the highest concentration of GOx tested, AP39 was no longer able to afford cytoprotective effects. Rats subjected to renal ischemia/reperfusion responded with a marked increase (over four-fold over sham control baseline) blood urea nitrogen and creatinine levels in blood, indicative of significant renal damage. This was associated with increased neutrophil infiltration into the kidneys (assessed by the myeloperoxidase assay in kidney homogenates), increased oxidative stress (assessed by the malondialdehyde assay in kidney homogenates), and an increase in plasma levels of IL-12. Pretreatment with AP39 (0.1, 0.2, and 0.3 mg/kg) provided a dose-dependent protection against these pathophysiological alterations; the most pronounced protective effect was observed at the 0.3 mg/kg dose of the H2S donor; nevertheless, AP39 failed to achieve a complete normalization of any of the injury markers measured. The partial protective effects of AP39 correlated with a partial improvement of kidney histological scores and reduced TUNEL staining (an indicator of DNA damage and apoptosis). In summary, the mitochondria-targeted H2S donor AP39 exerted dose-dependent protective effects against renal epithelial cell injury in vitro and renal ischemia-reperfusion injury in vivo. We hypothesize that the beneficial actions of AP39 are related to the reduction of cellular oxidative stress, and subsequent attenuation of various positive feed-forward cycles of inflammatory and oxidative processes. PMID:26513708

  8. Variability of Balmer Profiles in Magnetic Ap/Bp Stars

    NASA Astrophysics Data System (ADS)

    Valyavin, G.; Lee, B.-C.; Shulyak, D.; Han, I.; Kochukhov, O.; Khang, D.-I.; Kim, K.-M.

    2007-06-01

    A set of high precision measurements of weak variations of hydrogen lines in spectra of seven magnetic Ap/Bp stars was carried out using the BOES echelle spectrograph of the Bohuynsan Optical Astronomy Observatory (South Korea). A weak (1-2 %) periodic variability of the Balmer line wings has been detected in the spectra of 2 program stars. Upper limits of possible variations are presented for the remaining 5 objects. We discuss the discovered variability in the framework of model atmospheres with magnetic force terms included. The periodic changes in the Balmer profiles are caused by perturbations in atmospheres of Ap/Bp stars due to their rotationally modulated non-force-free magnetic fields.

  9. Airborne Precision Spacing (APS) Dependent Parallel Arrivals (DPA)

    NASA Technical Reports Server (NTRS)

    Smith, Colin L.

    2012-01-01

    The Airborne Precision Spacing (APS) team at the NASA Langley Research Center (LaRC) has been developing a concept of operations to extend the current APS concept to support dependent approaches to parallel or converging runways along with the required pilot and controller procedures and pilot interfaces. A staggered operations capability for the Airborne Spacing for Terminal Arrival Routes (ASTAR) tool was developed and designated as ASTAR10. ASTAR10 has reached a sufficient level of maturity to be validated and tested through a fast-time simulation. The purpose of the experiment was to identify and resolve any remaining issues in the ASTAR10 algorithm, as well as put the concept of operations through a practical test.

  10. The APS booster synchrotron: Commissioning and operational experience

    SciTech Connect

    Milton, S.V.

    1995-07-01

    The Advanced Photon Source (APS) at Argonne National Laboratory (ANL) was constructed to provide a large user community with intense and high brightness synchrotron radiation at x-ray wavelengths. A 7-GeV positron beam is used to generate this light. Acceleration of the beam from 450 MeV to 7 GeV is accomplished at a 2-Hz repetition rate by the booster synchrotron. Commissioning of the booster began in the second quarter of 1994 and continued on into early 1995. The booster is now routinely used to provide beam for the commissioning of the APS storage ring. Reported here are our commissioning and operational experiences with the booster synchrotron.

  11. Status of APS 1-Mwe Parabolic Trough Project

    SciTech Connect

    Canada, S.; Brosseau, D.; Kolb, G.; Moore, L.; Cable, R.; Price, H.

    2005-11-01

    Arizona Public Service (APS) is currently installing new power facilities to generate a portion of its electricity from solar resources that will satisfy its obligation under the Arizona Environmental Portfolio Standard (EPS). During FY04, APS began construction on a 1-MWe parabolic trough concentrating solar power plant. This plant represents the first parabolic trough plant to begin construction since 1991. Site preparation and construction activities continued throughout much of FY05, and startup activities are planned for Fall 2005 (with completion early in FY06). The plant will be the first commercial deployment of the Solargenix parabolic trough collector technology developed under contract to the National Renewable Energy Laboratory. The plant will use an organic Rankine cycle (ORC) power plant, provided by Ormat. The ORC power plant is much simpler than the conventional steam Rankine cycle plant and allows unattended operation of the facility.

  12. APS/ESRF/SPring-8 2008 three-way meeting.

    SciTech Connect

    Davey, S.; APS Engineering Support Division

    2008-07-01

    To foster scientific collaborations among the Advanced Photon Source (APS), the European Synchrotron Radiation Facility (ESRF), and the Super Photon Ring-8 GeV (SPring-8), the three facilities meet on a regular basis to hold technical discussions on accelerator and beamline topics and management and operational issues of common interest. The 2008 Three-Way Meeting (3WM) was held on March 18-19 at the APS with more than 20 representatives from each facility. Satellite workshops were also held on the topics of X-ray Optics, Nanoscience with X-rays, User Services, and Accelerator R&D. The 3WM and satellite workshops served as platforms for presentations and discussions of new and exciting developments at the three synchrotron sources.

  13. Time resolved spectroscopy of the cool Ap star HD 213637*

    NASA Astrophysics Data System (ADS)

    Elkin, V. G.; Kurtz, D. W.; Mathys, G.

    2015-02-01

    We present an analysis of high time resolution spectra of the chemically peculiar Ap star HD 213637. The star shows rapid radial velocity variations with a period close to the photometric pulsation period. Radial velocity pulsation amplitudes vary significantly for different rare earth elements. The highest pulsation amplitudes belong to lines of Tb III (˜360 m s-1), Pr II (˜250 m s-1) and Pr III (˜230 m s-1). We did not detect any pulsations from spectral lines of Eu II and in Hα, in contrast to many other roAp stars. We also did not find radial velocity pulsations using spectral lines of other chemical elements, including Mg, Si, Ca, Sc, Cr, Fe, Ni, Y and Ba. There are phase shifts between the maxima of pulsation amplitudes of different rare earth elements and ions, which is evidence of an outwardly running magneto-acoustic wave propagating through the upper stellar atmosphere.

  14. Architecture of the APS real-time orbit feedback system.

    SciTech Connect

    Carwardine, J. A.; Lenkszus, F. R.

    1997-11-21

    The APS Real-Time Orbit Feedback System is designed to stabilize the orbit of the stored positron beam against low-frequency sources such as mechanical vibration and power supply ripple. A distributed array of digital signal processors is used to measure the orbit and compute corrections at a 1kHz rate. The system also provides extensive beam diagnostic tools. This paper describes the architectural aspects of the system and describes how the orbit correction algorithms are implemented.

  15. Diffusion and Settling in Ap/Bp Stars

    SciTech Connect

    Turcotte, S

    2003-04-09

    Ap/Bp stars are magnetic chemically peculiar early A and late B type stars of the main sequence. They exhibit peculiar surface abundance anomalies that are thought to be the result of gravitational settling and radiative levitation. The physics of diffusion in these stars are reviewed briefly and some model predictions are discussed. While models reproduce some observations reasonably well, more work is needed before the behavior of diffusing elements in a complex magnetic field is fully understood.

  16. Linking radio and gamma-ray emission in Ap Librae

    NASA Astrophysics Data System (ADS)

    Hervet, O.; Boisson, C.; Sol, H.

    2015-06-01

    Ap Lib is one of the rare low-synchrotron-peaked blazars detected so far at TeV energies. This type of source is not properly modelled by standard one-zone leptonic synchrotron self-Compton (SSC) emission scenarios. The aim of this paper is to study the relevance of additional components that should naturally occur in an SSC scenario for a better understanding of the emission mechanisms, especially at very high energies (VHE). We use simultaneous data from a multi-wavelength campaign of the Planck, Swift-UVOT, and Swift-XRT telescopes carried out in February 2010, as well as quasi-simultaneous data of WISE, Fermi, and HESS taken in 2010. The multi-lambda emission of Ap Lib is modelled by a blob-in-jet SSC scenario including the contribution of the base of the VLBI-extended jet, the radiative blob-jet interaction, the accretion disk, and its associated external photon field. We show that signatures of a strong parsec-scale jet and of an accretion disk emission are present in the spectral energy distribution. We can link the observational VLBI jet features from MOJAVE to parameters expected for a VHE-emitting blob accelerated near the jet base. The VHE emission appears to be dominated by the inverse-Compton effect of the blob relativistic electrons interacting with the jet synchrotron radiation. In this scenario, Ap Lib appears as an intermediate source between BL Lac objects and flat-spectrum radio quasars. Ap Lib could be a bright representative of a specific class of blazars, in which the parsec-scale jet luminosity is no more negligible compared to the blob and contributes to the high-energy emission through inverse-Compton processes.

  17. Cortical regulation of subcortical dopamine release: mediation via the ventral tegmental area.

    PubMed

    Taber, M T; Das, S; Fibiger, H C

    1995-09-01

    In vivo microdialysis was used to determine the extent to which ionotropic glutamate receptors in the ventral tegmental area (VTA) regulate dopamine release in the nucleus accumbens. Coapplication of 2-amino-5-phosphonopentanoic acid (AP5; 200 microM) and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX; 50 microM) to the VTA via reverse dialysis decreased extracellular concentrations of dopamine in the nucleus accumbens by approximately 30%. In accordance with previous results, electrical stimulation of the prefrontal cortex increased dopamine release by 60%. Application of AP5 and CNQX to the VTA during cortical stimulation blocked the effect of stimulation on dopamine release. These results indicate that ionotropic glutamate receptors in the VTA are critically involved in basal and evoked dopamine release in the nucleus accumbens and suggest that a glutamatergic projection from the prefrontal cortex regulates the activity of dopaminergic neurons in the VTA. PMID:7643120

  18. Fungi in the Ancient World: How Mushrooms, Mildews, Molds and Yeast Shaped the Early Civilizations of Europe, the Mediterranean, and the Near East. APS Press, St. Paul, MN.

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This monograph comprises a survey of roles of fungi in ancient societies of the western tradition or its predecessors in Egypt and western Asia. Topics include the use of yeasts in brewing and baking, poisonous and mycotoxigenic fungi, fungi used for medicinal purposes or for other technologies, pla...

  19. Dynamic Regulation of AP-1 Transcriptional Complexes Directs Trophoblast Differentiation

    PubMed Central

    Kent, Lindsey N.; Rumi, M. A. Karim; Roby, Katherine F.

    2015-01-01

    Placentation is a process that establishes the maternal-fetal interface and is required for successful pregnancy. The epithelial component of the placenta consists of trophoblast cells, which possess the capacity for multilineage differentiation and are responsible for placenta-specific functions. FOS-like antigen 1 (FOSL1), a component of AP-1 transcription factor complexes, contributes to the regulation of placental development. FOSL1 expression is restricted to trophoblast giant cells and invasive trophoblast cells. In the present study, we characterized the FOSL1 regulatory pathway in rat trophoblast cells. Transcriptome profiling in control and FOSL1 knockdown cells identified FOSL1-dependent gene sets linked to endocrine and invasive functions. FOSL1 was shown to occupy AP-1 binding sites within these gene loci, as determined by chromatin immunoprecipitation (ChIP). Complementary in vivo experiments using trophoblast-specific lentiviral delivery of FOSL1 short hairpin RNAs (shRNAs) provided in vivo validation of FOSL1 targets. FOSL1 actions require a dimerization partner. Coimmunoprecipitation, coimmunolocalization, and ChIP analyses showed that FOSL1 interacts with JUNB and, to a lesser extent, JUN in differentiating trophoblast cells. Knockdown of FOSL1 and JUNB expression inhibited both endocrine and invasive properties of trophoblast cells. In summary, FOSL1 recruits JUNB to form AP-1 transcriptional complexes that specifically regulate the endocrine and invasive trophoblast phenotypes. PMID:26149388

  20. Margin Assessment of AP1000 Loss of Flow Transient

    SciTech Connect

    Carlin, Edward L.; Hilton, Peter A.; Yixing Sung

    2006-07-01

    The Reactor Coolant System (RCS) of the AP1000 plant consists of two circulating loops. Each loop contains two canned motor Reactor Coolant (RC) pumps that have a rotating inertia to provide RCS flow coast-down if power to the pumps is lost. Westinghouse analysis of the complete loss of flow (CLOF) accident in support of the AP1000 design certification was based on the USNRC-approved traditional methodology applied to operating plants. The RCS response during the transient was predicted using the LOFTRAN code based on a reactivity insertion curve highly skewed to the bottom of the reactor core, but the calculation of Departure from Nucleate Boiling Ratio (DNBR) was performed assuming a top-skewed axial power profile. A more realistic margin assessment can be made by using an improved method similar to Westinghouse RAVE methodology recently approved by the USNRC. The improved method uses the three-dimensional kinetic nodal code SPNOVA coupled with the reactor core thermal-hydraulic code VIPRE-W for predicting the reactor core response during the CLOF transient. The improved method significantly improves margin predictions by generating core power distributions consistent with the trip reactivity changes for the DNBR calculation. The margin assessment showed that the improved method resulted in a 19% DNBR increase as compared to the traditional method for the AP1000 CLOF transient. (authors)