Science.gov

Sample records for aps press release

  1. Astronomy Press Releases: What We Choose To Share

    NASA Astrophysics Data System (ADS)

    Gay, Pamela L.

    2009-01-01

    Everyday, astronomy departments and facilities around the world issue press releases via the AAS Press Release service. These stories are selected for a variety of reasons that often (but do not always) include: the significance of a discover, public appeal, it is a first/last/largest/smallest discovery, and something historic has occurred (for instance, launch of a space craft). What astronomers as a field select to communicate to the public via press releases shapes public understanding of astronomy.In this poster, 6 months of press releases sent via email from the AAS Press Release service are examined to see how astronomy was communicated from January 1, 2008 through June 30, 2008. Press Releases are classified by topic using Astrophysical Journal keywords to look for trends, and the words used in the titles are studied to see what words press officers and scientists are using to communicate and to entice content providers into reporting their stories. Additionally, the first 100 discrete discoveries are examined to see which releases have more coverage within the blogisphere and trends in what is and is not covered are examined.

  2. GPI-AP release in cellular, developmental, and reproductive biology.

    PubMed

    Fujihara, Yoshitaka; Ikawa, Masahito

    2016-04-01

    Glycosylphosphatidylinositol-anchored proteins (GPI-APs) contain a covalently linked GPI anchor located on outer cell membranes. GPI-APs are ubiquitously conserved from protozoa to vertebrates and are critical for physiological events such as development, immunity, and neurogenesis in vertebrates. Both membrane-anchored and soluble GPI-APs play a role in regulating their protein conformation and functional properties. Several pathways mediate the release of GPI-APs from the plasma membrane by vesiculation or cleavage. Phospholipases and putative substrate-specific GPI-AP-releasing enzymes, such as NOTUM, glycerophosphodiesterase 2, and angiotensin-converting enzyme, have been characterized in mammals. Here, the protein modifications resulting from the cleavage of the GPI anchor are discussed in the context of its physiological functions. PMID:26593072

  3. The CAPRI Project: Coordinates for Astronomical Press Release Images

    NASA Astrophysics Data System (ADS)

    Frattare, Lisa M.; Ferguson, B. A.; Summers, F.; Levay, Z. G.

    2009-01-01

    The beauty and splendor of astronomical press release images has made an enormously positive impact with the media and public alike. As a leading provider of astronomical imagery and a major contributor of Hubble Space Telescope press release images, the outreach division of Space Telescope Science Institute (STScI) recognizes the importance of making press release images compliant with virtual observatory standards for inclusion in databases and repositories. Our goal is to make outreach images accessible by virtual observatory applications by calculating World Coordinate System (WCS) data for these images. We provide updated and improved software that allows observatories to easily and accurately transform coordinates on their astronomical press release images, using reference FITS files. The resultant metadata conforms to the Simple Image Access (SIA) protocol established by the International Virtual Observatory Alliance and has been used by popular end users such as Google Sky and World Wide Telescope. Several hundred images from the STScI Office of Public Outreach NewsCenter database have been processed, and their coordinates and other relevant metadata are accessible through an SIA-compliant web service.

  4. Modulation of Venlafaxine Hydrochloride Release from Press Coated Matrix Tablet

    PubMed Central

    Gohel, M. C.; Soni, C. D.; Nagori, S. A.; Sarvaiya, K. G.

    2008-01-01

    The aim of present study was to prepare novel modified release press coated tablets of venlafaxine hydrochloride. Hydroxypropylmethylcellulose K4M and hydroxypropylmethylcellulose K100M were used as release modifier in core and coat, respectively. A 32 full factorial design was adopted in the optimization study. The drug to polymer ratio in core and coat were chosen as independent variables. The drug release in the first hour and drug release rate between 1 and 12 h were chosen as dependent variables. The tablets were characterized for dimension analysis, crushing strength, friability and in vitro drug release. A check point batch, containing 1:2.6 and 1:5.4 drug to polymer in core and coat respectively, was prepared. The tablets of check point batch were subjected to in vitro drug release in dissolution media with pH 5, 7.2 and distilled water. The kinetics of drug release was best explained by Korsmeyer and Peppas model (anomalous non-Fickian diffusion). The systematic formulation approach enabled us to develop modified release venlafaxine hydrochloride tablets. PMID:20046735

  5. OPEC official resolutions and press releases 1960-1983

    SciTech Connect

    Not Available

    1984-01-01

    This book presents resolutions adopted by the OPEC Conference constitute a unique and historic documentary record of the Organization's achievements in the 23 years since its foundation in Baghdad in 1960. Also included in this special work of reference is a selection of Press Releases which announced important developments in OPEC's evolution. Arranged in chronological order, these documents provide a step-by-step account of the major developments which have had such a profound effect and continuing impact on the world's economic affairs.

  6. Optimization of propranolol HCl release kinetics from press coated sustained release tablets.

    PubMed

    Ali, Adel Ahmed; Ali, Ahmed Mahmoud

    2013-01-01

    Press-coated sustained release tablets offer a valuable, cheap and easy manufacture alternative to the highly expensive, multi-step manufacture and filling of coated beads. In this study, propranolol HCl press-coated tablets were prepared using hydroxylpropylmethylcellulose (HPMC) as tablet coating material together with carbopol 971P and compressol as release modifiers. The prepared formulations were optimized for zero-order release using artificial neural network program (INForm, Intelligensys Ltd, North Yorkshire, UK). Typical zero-order release kinetics with extended release profile for more than 12 h was obtained. The most important variables considered by the program in optimizing formulations were type and proportion of polymer mixture in the coat layer and distribution ratio of drug between core and coat. The key elements found were; incorporation of 31-38 % of the drug in the coat, fixing the amount of polymer in coat to be not less than 50 % of coat layer. Optimum zero-order release kinetics (linear regression r2 = 0.997 and Peppas model n value > 0.80) were obtained when 2.5-10 % carbopol and 25-42.5% compressol were incorporated into the 50 % HPMC coat layer. PMID:22582904

  7. The association between exaggeration in health related science news and academic press releases: retrospective observational study

    PubMed Central

    Vivian-Griffiths, Solveiga; Boivin, Jacky; Williams, Andy; Venetis, Christos A; Davies, Aimée; Ogden, Jack; Whelan, Leanne; Hughes, Bethan; Dalton, Bethan; Boy, Fred

    2014-01-01

    Objective To identify the source (press releases or news) of distortions, exaggerations, or changes to the main conclusions drawn from research that could potentially influence a reader’s health related behaviour. Design Retrospective quantitative content analysis. Setting Journal articles, press releases, and related news, with accompanying simulations. Sample Press releases (n=462) on biomedical and health related science issued by 20 leading UK universities in 2011, alongside their associated peer reviewed research papers and news stories (n=668). Main outcome measures Advice to readers to change behaviour, causal statements drawn from correlational research, and inference to humans from animal research that went beyond those in the associated peer reviewed papers. Results 40% (95% confidence interval 33% to 46%) of the press releases contained exaggerated advice, 33% (26% to 40%) contained exaggerated causal claims, and 36% (28% to 46%) contained exaggerated inference to humans from animal research. When press releases contained such exaggeration, 58% (95% confidence interval 48% to 68%), 81% (70% to 93%), and 86% (77% to 95%) of news stories, respectively, contained similar exaggeration, compared with exaggeration rates of 17% (10% to 24%), 18% (9% to 27%), and 10% (0% to 19%) in news when the press releases were not exaggerated. Odds ratios for each category of analysis were 6.5 (95% confidence interval 3.5 to 12), 20 (7.6 to 51), and 56 (15 to 211). At the same time, there was little evidence that exaggeration in press releases increased the uptake of news. Conclusions Exaggeration in news is strongly associated with exaggeration in press releases. Improving the accuracy of academic press releases could represent a key opportunity for reducing misleading health related news. PMID:25498121

  8. EXPOSURE AND RELEASE ESTIMATIONS FOR FILTER PRESS AND TRAY DRYER OPERATIONS BASED ON PILOT PLANT DATA

    EPA Science Inventory

    Worker exposures and chemical releases associated with a plate-and-frame filter press and a stationary tray dryer were studied in a pilot plant. he equipment was representative of those in a chemical manufacturing plant; the filter press was previously used at a chemical plant, a...

  9. Vesicles derived via AP-3-dependent recycling contribute to asynchronous release and influence information transfer.

    PubMed

    Evstratova, Alesya; Chamberland, Simon; Faundez, Victor; Tóth, Katalin

    2014-01-01

    Action potentials trigger synchronous and asynchronous neurotransmitter release. Temporal properties of both types of release could be altered in an activity-dependent manner. While the effects of activity-dependent changes in synchronous release on postsynaptic signal integration have been studied, the contribution of asynchronous release to information transfer during natural stimulus patterns is unknown. Here we find that during trains of stimulations, asynchronous release contributes to the precision of action potential firing. Our data show that this form of release is selectively diminished in AP-3b2 KO animals, which lack functional neuronal AP-3, an adaptor protein regulating vesicle formation from endosomes generated during bulk endocytosis. We find that in the absence of neuronal AP-3, asynchronous release is attenuated and the activity-dependent increase in the precision of action potential timing is compromised. Lack of asynchronous release decreases the capacity of synaptic information transfer and renders synaptic communication less reliable in response to natural stimulus patterns. PMID:25410111

  10. Corporate Responsibility in Communication: Empirical Analysis of Press Releases in a Conflict

    ERIC Educational Resources Information Center

    Lehtimaki, Hanna; Kujala, Johanna; Heikkinen, Anna

    2011-01-01

    The paper examines how the tensions of corporate responsibility are articulated and reconciled in a controversial situation of a foreign investment. We conducted a conventionalist analysis on the company press releases in a case where a Finnish forest industry company invested in a pulp mill in South America. The findings show that the use of…

  11. Distorting Genetic Research about Cancer: From Bench Science to Press Release to Published News1

    PubMed Central

    Brechman, Jean M.; Lee, Chul-joo; Cappella, Joseph

    2014-01-01

    This study considered genetic research relating to cancer outcomes and behaviors, specifically investigating the extent to which claims made in press releases (N=23) and mainstream print media (N=71) were fairly derived from their original presentation in scholarly journals (N=20). Central claims expressing gene-outcome relationships were evaluated by a large pool (N=40) of genetics graduate students. Raters judged press release claims as significantly more representative of material within the original science journal article compared with news article claims. Claims originating in news articles which demonstrated contact with individuals not directly involved in the research were judged by experts to be more representative of the original science as compared with those that demonstrated contact with individuals directly involved in the research. PMID:25580022

  12. Credibility of science communication: An exploratory study of astronomy press releases

    NASA Astrophysics Data System (ADS)

    Nielsen, L. H.; Torpe Jørgensen, N.; Jantzen, K.; Christensen, L. L.

    2008-06-01

    Current developments in the media marketplace and an increased need for visibility to secure funding are leading inevitably to faster, simpler and more aggressive science communication. This article presents the results of an exploratory study of potential credibility problems in astronomy press releases, their causes, consequences and possible remedies. The study consisted of eleven open-ended interviews with journalists, scientists and public information officers. Results suggest that credibility issues are central to communication, deeply integrated into the workflow and can have severe consequences for the actors (especially the scientist), but are an unavoidable part of the communication process. In general a major credibility problem was not found to exist for astronomical press releases.

  13. "Discoveries in Planetary Sciences": Turning Press Release Science into Teachable Moments in Higher Ed

    NASA Astrophysics Data System (ADS)

    Schneider, N. M.; Brain, D.; Sada, P. V.

    2011-12-01

    AGU disciplines are all fields that evolve rapidly, and it can take several years for new advances to work their way into college textbooks. Yet it is important for students to have exposure to these new advances for a number of reasons. In some cases, new work renders older textbook knowledge incorrect or incomplete. In some cases, new discoveries make it possible to emphasize older textbook knowledge in a new way. In all cases, new advances provide exciting and accessible examples of the scientific process in action. But press releases rarely provide these "teachable moments" in either content or format. To bridge the gap between textbooks and new advances in planetary sciences, we have developed content on new discoveries for use by undergraduate instructors. Called 'Discoveries in Planetary Sciences', each new discovery is summarized in a 3-slide PowerPoint presentation. The first slide describes the discovery, the second slide discusses the underlying planetary science concepts, and the third presents the big picture implications of the discovery. A fourth slide includes links to associated press releases, images, and primary sources. This effort is generously sponsored by the Division for Planetary Sciences of the American Astronomical Society, and the slide sets are available at http://dps.aas.org/education/dpsdisc/. More than twenty slide sets have been released so far covering topics spanning all sub-disciplines of planetary science, with a fall release planned for Spanish translations In this presentation we will discuss our motivation for this project, our implementation approach (from choosing topics to creating the slide sets, to getting them reviewed and released), and give examples of slide sets. We will present information in the form of web statistics on how many educators are using the slide sets, and which topics are most popular. We will also present feedback from educators who have used them in the classroom. The value and popularity of these

  14. Outrage Factors in Government Press Releases of Food Risk and Their Influence on News Media Coverage.

    PubMed

    Ju, Youngkee; Lim, Jeongsub; Shim, Minsun; You, Myoungsoon

    2015-08-01

    An appropriate level of risk perception should be a critical issue in modern "risk society." There have been many studies on the influences on risk perception. This study investigates whether risk communication scholar Dr. Peter Sandman's outrage factors intensify journalistic attention to health risks from food consumption. A content analysis of a health institution's press releases was conducted to examine 15 outrage factors of food risks conveyed in the governmental risk communication. In addition, the news stories covering the food risks informed by the press releases were calculated to evaluate the relation between outrage factors of a risk and the number of news stories covering the risk. Results showed that controllability was the most salient outrage factor, followed by trust, voluntariness, familiarity, and human origin; the greater the outrage score of a risk, the more news stories of the risk. For individual outrage factors, a risk with an implication of catastrophic potential was associated with an increase of news stories. Food providers' distrustful behaviors also influenced journalistic attention to the food risks. The implication of the findings to health message designers is discussed. PMID:26065830

  15. The rural restaurant healthy options program: response of rural, local newspapers to a program press release.

    PubMed

    Nothwehr, Faryle; Andsager, Julie; Haines, Heidi

    2014-03-01

    Local media should be used to raise awareness of health promotion programs. In rural areas, local newspapers provide an opportunity to reach large numbers of residents. Although there are expert guidelines describing the process for successfully engaging local media, little has been documented regarding the range of responses that local, rural newspapers might have when approached about covering health promotion programs. This study describes the response of rural, local newspapers to a press release about a health promotion program taking place in 28 restaurants in different rural towns. The most common reason for not publishing a story was that it would constitute free advertising for the restaurant. Twenty-two stories were analyzed using descriptive statistics. The majority of the responding newspapers were weeklies, and 16 published the full press release verbatim. Three stories included photos, and five included quotes. Headlines typically included the name of the restaurant and the university partner. The overall response rate is encouraging; however, there is considerable room for improvement in terms of personalizing the story with photos or quotes. Greater efforts may be required to obtain this depth of coverage, including training for local journalists to increase their interest and confidence in covering health promotion issues. PMID:23182860

  16. From press release to news: mapping the framing of the 2009 H1N1 A influenza pandemic.

    PubMed

    Lee, Seow Ting; Basnyat, Iccha

    2013-01-01

    Pandemics challenge conventional assumptions about health promotion, message development, community engagement, and the role of news media. To understand the use of press releases in news coverage of pandemics, this study traces the development of framing devices from a government public health agency's press releases to news stories about the 2009 H1N1 A influenza pandemic. The communication management of the H1N1 pandemic, an international news event with local implications, by the Singapore government is a rich locus for understanding the dynamics of public relations, health communication, and journalism. A content analysis shows that the evolution of information from press release to news is marked by significant changes in media frames, including the expansion and diversification in dominant frames and emotion appeals, stronger thematic framing, more sources of information, conversion of loss frames into gain frames, and amplification of positive tone favoring the public health agency's position. Contrary to previous research that suggests that government information subsidies passed almost unchanged through media gatekeepers, the news coverage of the pandemic reflects journalists' selectivity in disseminating the government press releases and in mediating the information flow and frames from the press releases. PMID:22439616

  17. Lost in Translation? A Comparison of Cancer-Genetics Reporting in the Press Release and its Subsequent Coverage in Lay Press1

    PubMed Central

    Brechman, Jean M.; Lee, Chul-joo; Cappella, Joseph N.

    2014-01-01

    Understanding how genetic science is communicated to the lay public is of great import, given that media coverage of genetics is increasing exponentially and that the ways in which discoveries are presented in the news can have significant effects on a variety of health outcomes. To address this issue, this study examines the presentation of genetic research relating to cancer outcomes and behaviors (i.e., prostate cancer, breast cancer, colon cancer, smoking and obesity) in both the press release (N = 23) and its subsequent news coverage (N = 71) by using both quantitative content analysis and qualitative textual analysis. In contrast to earlier studies reporting that news stories often misrepresent genetics by presenting biologically deterministic and simplified portrayals (e.g., Mountcastle-Shah et al., 2003; Ten Eych & Williment, 2003), our data shows no clear trends in the direction of distortion toward deterministic claims in news articles. Also, other errors commonly attributed to science journalism, such as lack of qualifying details and use of oversimplified language (e.g., “fat gene”) are observed in press releases. These findings suggest that the intermediary press release rather than news coverage may serve as a source of distortion in the dissemination of science to the lay public. The implications of this study for future research in this area are discussed. PMID:25568611

  18. Development and optimization of press coated tablets of release engineered valsartan for pulsatile delivery.

    PubMed

    Shah, Sunny; Patel, Romik; Soniwala, Moinuddin; Chavda, Jayant

    2015-01-01

    The present work is aimed to develop and optimize pulsatile delivery during dissolution of an improved formulation of valsartan to coordinate the drug release with circadian rhythm. Preliminary studies suggested that β cyclodextrin could improve the solubility of valsartan and showed AL type solubility curve. A 1:1 stoichiometric ratio of valsartan to β cyclodextrin was revealed from phase solubility studies and Job's plot. The prepared complex showed significantly better dissolution efficiency (p < 0.05) compared to pure drug, which could be due to the formation of inclusion complex as revealed from FTIR and DSC studies. Continuous dissolution-absorption studies revealed that absorption of drug from valsartan β cyclodextrin complex was significantly higher (p < 0.05) compared to pure drug, in second part press-coated tablets of valsartan β cyclodextrin complex were subsequently prepared and application of the Plackett-Burman screening design revealed that HPMC K4M and EC showed significant effect on lag time. A 3(2) full factorial design was used to measure the response of HPMC K4M and EC on lag time and time taken for 90% drug release (T90). The optimized batch prepared according to the levels obtained from the desirability function had a lag time of 6 h and consisted of HPMC K4M:ethylcellulose in a 1:1.5 ratio with 180 mg of coating and revealed a close agreement between observed and predicted value (R(2 )= 0.9694). PMID:25721985

  19. Coverage of Team Science by Public Information Officers: Content Analysis of Press Releases about the National Science Foundation Science and Technology Centers

    ERIC Educational Resources Information Center

    Graube, Marita; Clark, Fiona; Illman, Deborah L.

    2010-01-01

    This study examines the content of press releases from the National Science Foundation (NSF) Science and Technology Centers (STCs) to determine how public information officers (PIOs) presented the outcomes of centers to journalists and the public. A total of 68 press releases were analyzed for type of news covered, visibility of centers and their…

  20. Disruption of adaptor protein 2μ (AP-2μ) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing.

    PubMed

    Jung, SangYong; Maritzen, Tanja; Wichmann, Carolin; Jing, Zhizi; Neef, Andreas; Revelo, Natalia H; Al-Moyed, Hanan; Meese, Sandra; Wojcik, Sonja M; Panou, Iliana; Bulut, Haydar; Schu, Peter; Ficner, Ralf; Reisinger, Ellen; Rizzoli, Silvio O; Neef, Jakob; Strenzke, Nicola; Haucke, Volker; Moser, Tobias

    2015-11-01

    Active zones (AZs) of inner hair cells (IHCs) indefatigably release hundreds of vesicles per second, requiring each release site to reload vesicles at tens per second. Here, we report that the endocytic adaptor protein 2μ (AP-2μ) is required for release site replenishment and hearing. We show that hair cell-specific disruption of AP-2μ slows IHC exocytosis immediately after fusion of the readily releasable pool of vesicles, despite normal abundance of membrane-proximal vesicles and intact endocytic membrane retrieval. Sound-driven postsynaptic spiking was reduced in a use-dependent manner, and the altered interspike interval statistics suggested a slowed reloading of release sites. Sustained strong stimulation led to accumulation of endosome-like vacuoles, fewer clathrin-coated endocytic intermediates, and vesicle depletion of the membrane-distal synaptic ribbon in AP-2μ-deficient IHCs, indicating a further role of AP-2μ in clathrin-dependent vesicle reformation on a timescale of many seconds. Finally, we show that AP-2 sorts its IHC-cargo otoferlin. We propose that binding of AP-2 to otoferlin facilitates replenishment of release sites, for example, via speeding AZ clearance of exocytosed material, in addition to a role of AP-2 in synaptic vesicle reformation. PMID:26446278

  1. EVALUATION OF CHEMICAL RELEASES AND WORKER EXPOSURES FROM FILTER PRESS OPERATIONS

    EPA Science Inventory

    The exposures (inhalation and dermal) and releases (air, water, solids, and process streams) associated with the filtration of industrial wastewater sludge from an electronics manufacturing plant were characterized. Chemical releases and worker exposures for a target chemical (t...

  2. When Medical News Comes from Press Releases-A Case Study of Pancreatic Cancer and Processed Meat.

    PubMed

    Taylor, Joseph W; Long, Marie; Ashley, Elizabeth; Denning, Alex; Gout, Beatrice; Hansen, Kayleigh; Huws, Thomas; Jennings, Leifa; Quinn, Sinead; Sarkies, Patrick; Wojtowicz, Alex; Newton, Philip M

    2015-01-01

    The media have a key role in communicating advances in medicine to the general public, yet the accuracy of medical journalism is an under-researched area. This project adapted an established monitoring instrument to analyse all identified news reports (n = 312) on a single medical research paper: a meta-analysis published in the British Journal of Cancer which showed a modest link between processed meat consumption and pancreatic cancer. Our most significant finding was that three sources (the journal press release, a story on the BBC News website and a story appearing on the 'NHS Choices' website) appeared to account for the content of over 85% of the news stories which covered the meta analysis, with many of them being verbatim or moderately edited copies and most not citing their source. The quality of these 3 primary sources varied from excellent (NHS Choices, 10 of 11 criteria addressed) to weak (journal press release, 5 of 11 criteria addressed), and this variance was reflected in the accuracy of stories derived from them. Some of the methods used in the original meta-analysis, and a proposed mechanistic explanation for the findings, were challenged in a subsequent commentary also published in the British Journal of Cancer, but this discourse was poorly reflected in the media coverage of the story. PMID:26083640

  3. Plutonium release from pressed plutonium oxide fuel pellets in aquatic environments

    SciTech Connect

    Patterson, J.H.; Steinkruger, F.J.; Matlack, G.M.; Heaton, R.C.; Coffelt, K.P.; Herrera, B.

    1983-12-01

    Plutonium oxide pellets (80% /sup 238/Pu, 40 g each) were exposed to fresh water and sea water at two temperatures for 3 y in enclosed glass chambers. The concentrations of plutonium observed in the waters increased linearly with time throughout the experiment. However, the observed release rates were inversely dependent on temperature and salinity, ranging from 160 ..mu..Ci/day for cold fresh water to 1.4 ..mu..Ci/day for warm sea water. The total releases, including the chamber residues, showed similar dependencies. A major portion (typically greater than 50%) of the released plutonium passed through a 0.1-..mu..m filter, with even larger fractions (greater than 80%) for the fresh water systems.

  4. Thermally induced atomic diffusion at the interface between release agent coating and mould substrate in a glass moulding press

    NASA Astrophysics Data System (ADS)

    Masuda, Jun; Yan, Jiwang; Zhou, Tianfeng; Kuriyagawa, Tsunemoto; Fukase, Yasushi

    2011-06-01

    In a glass moulding press (GMP) for refractive/diffractive hybrid lenses, to improve the service life of nickel-phosphorus (Ni-P) plated moulds, it is necessary to control the diffusion of constituent elements from the mould into the release agent coating. In this study, diffusion phenomena of constituents of Ni-P plating are investigated for two types of release agent coatings, iridium-platinum (Ir-Pt) and iridium-rhenium (Ir-Re), by cross-sectional observation, compositional analysis and stress measurements. The results show that Ni atoms in the plating layer flow from regions of compressive stress to regions of tensile stress. In the case of the Ir-Pt coated mould, the diffusion of Ni is promoted from the grain boundaries between the Ni and Ni3P phases in the plating towards the surface of the Ir-Pt coating. However, in the Ir-Re coated mould, the diffusion of Ni is suppressed because the diffusion coefficient of Ni in the Ir-Re alloy is smaller than that in the Ir-Pt alloy, although the stress state is similar in both cases. By controlling the diffusion of Ni atoms, the use of Ir-Re alloy as a release agent coating for Ni-P plated moulds is expected to lead to a high degree of durability.

  5. Formaldehyde release from durable-press apparel textiles. Final project report to the US Consumer Product Safety Commission

    SciTech Connect

    Matthews, T.G.; Daffron, C.R.; Merchant, E.R.

    1985-10-01

    A survey of formaldehyde (CH/sub 2/O) release from durable-press apparel textiles has been performed to better characterize the CH/sub 2/O emission properties of fabrics marketed in the US. An intercomparison of the ORNL extraction, the Japanese standard and the American Association of Textile Chemists and Colorists (AATCC) sealed jar methods using 12 fabrics selected from the textile survey yielded an average emission ratio of 0.46 +- 0.16 for the ORNL/AATCC methods and 1.5 +- 0.5 for the ORNL/Japenese methods. The average CH/sub 2/O releases from the survey fabrics, as measured with the ORNL extraction test, were 117 +- 140, 58 +- 72, 19 +- 17 and 31 +- 29 ..mu..g CH/sub 2/O/g fabric for top-weight, bottom-weight, knit and flatgood categories, respectively. Formaldehyde releases of <100 ..mu..g CH/sub 2/O/g fabric were measured from 86% of the survey fabrics. Three to fourfold increases in CH/sub 2/O release were observed with additional seven to nine weeks of storage in a laboratory environment between repeated testing using the ORNL extraction test. The strongest emitting fabrics with initial emission levels of >125 ..mu..g CH/sub 2/O/g fabric exhibited a 74 +- 11% decline in CH/sub 2/O emission levels following the first washing, with an additional 13 +- 6% decline after the completion of six further washings. The weakest emitting fabrics with initial emission levels of <25 ..mu..g CH/sub 2/O/g fabric demonstrated both increases and decreases in CH/sub 2/O emission strength after washing but never exceeded 11 ..mu..g CH/sub 2/O/g fabric.

  6. Reciprocating pellet press

    DOEpatents

    Jones, Charles W.

    1981-04-07

    A machine for pressing loose powder into pellets using a series of reciprocating motions has an interchangeable punch and die as its only accurately machines parts. The machine reciprocates horizontally between powder receiving and pressing positions. It reciprocates vertically to press, strip and release a pellet.

  7. 76 FR 6328 - Official Release of the January 2011 AP-42 Method for Estimating Re-Entrained Road Dust From...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-04

    ... emissions model for SIPs and regional conformity purposes (75 FR 9411) and of the MOVES2010a and EMFAC models for transportation conformity hot-spot analyses (75 FR 79370). The January 2011 AP-42 method... January 2011 AP-42 method since significant work has already occurred and EPA intends to act on these...

  8. Landslide incidence in the North of Portugal: Analysis of a historical landslide database based on press releases and technical reports

    NASA Astrophysics Data System (ADS)

    Pereira, Susana; Zêzere, José Luís; Quaresma, Ivânia Daniela; Bateira, Carlos

    2014-06-01

    This work presents and explores the Northern Portugal Landslide Database (NPLD) for the period 1900-2010. NPLD was compiled from press releases (regional and local newspapers) and technical reports (reports by civil protection authorities and academic works); it includes 628 landslides, corresponding to 5.7 landslides per year on average. Although 50% of landslides occurred in the last 35 years of the series, the temporal distribution of landslides does not show any regular increase with time. The relationship between annual precipitation and landslide occurrence shows that reported landslides tend to be more frequent in wetter years. Moreover, landslides occur mostly in the wettest months of the year (December, January and February), which reflects the importance of rainfall in triggering slope instability. Most landslides cause damage that affects people and/or structures; 69.4% of the landslides in Northern Portugal caused 136 fatalities, 173 injured and left 460 persons homeless. More than half of the total landslides (321 landslides) led to railway or motorway closures and 49 landslides destroyed 126 buildings. The NPLD is compared with a landslide database for the whole of Portugal constructed from a single daily national newspaper covering the same reference period. It will be demonstrated that the regional and local newspapers are more effective than the national newspaper in reporting damaging landslides in the North of Portugal. Like other documentary-based landslide inventories, the NPLD does not accurately report non-damaging landslides. Therefore, NPLD was found unsuitable to validate municipal-scale landslide susceptibility models derived from detailed geomorphology-based landslide inventories.

  9. [The Universidad de Buenos Aires in the 1970s: analysis of the press release expressing solidarity with Rodolfo Puiggrós].

    PubMed

    Recalde, Aritz

    2012-12-01

    This article reconstructs the historical context surrounding the emission of a press release by authorities of the Universidad de Buenos Aires, expressing their solidarity with historian and university rector Rodolfo Puiggrós after his resignation. In his term, Puiggrós attempted to fuse the institution's scientific and technological plans with the new development model initiated by Héctor Cámpora and the Peronist movement in 1973. The article makes reference to the project of university transformation promoted by Puiggrós, combining the ideological traditions of Marxism, reformism, and nationalism. A few key points, useful for analyzing the reasons behind Puiggrós's resignation, are presented, and the arguments highlighted within this press release, published by Office of Media and Communications on October 5, 1973, are discussed. PMID:23681463

  10. Exposure and release estimations for filter-press and tray-dryer operations based on pilot-plant data. Final report

    SciTech Connect

    Marshall, M.C.; Howard, H.K.

    1992-03-20

    Worker exposures and chemical releases associated with a plate-and-frame filter press and a stationary tray dryer were studied in a pilot plant. The equipment was representative of those in a chemical manufacturing plant; the filter press was previously used at a chemical plant, and the dryer trays were the same size used by dye manufacturers. A randomized series of eight experiments identified the most influential variables for inhalation exposure during the tray drying unit operation which used approximately 100 kg of CaCO3. The range of conditions studied in the eight experiments provide inhalation exposure data for evaluating the impact of physical properties, the activities performed, and the influence of worker technique.

  11. Drill Presses.

    ERIC Educational Resources Information Center

    Engelbrecht, Nancy; And Others

    These instructional materials provide an orientation to the drill press for use at the postsecondary level. The first of seven sections lists seven types of drill presses. The second section identifies 14 drill press parts. The third section lists 21 rules for safe use of drilling machines. The fourth section identifies the six procedures for…

  12. Media Coverage, Journal Press Releases and Editorials Associated with Randomized and Observational Studies in High-Impact Medical Journals: A Cohort Study

    PubMed Central

    Wang, Michael T. M.; Bolland, Mark J.; Gamble, Greg; Grey, Andrew

    2015-01-01

    Background Publication of clinical research findings in prominent journals influences health beliefs and medical practice, in part by engendering news coverage. Randomized controlled trials (RCTs) should be most influential in guiding clinical practice. We determined whether study design of clinical research published in high-impact journals influences media coverage. Methods and Findings We compared the incidence and amount of media coverage of RCTs with that of observational studies published in the top 7 medical journals between 1 January 2013 and 31 March 2013. We specifically assessed media coverage of the most rigorous RCTs, those with >1000 participants that reported ‘hard’ outcomes. There was no difference between RCTs and observational studies in coverage by major newspapers or news agencies, or in total number of news stories generated (all P>0.63). Large RCTs reporting ‘hard’ outcomes did not generate more news coverage than small RCTs that reported surrogate outcomes and observational studies (all P>0.32). RCTs were more likely than observational studies to attract a journal editorial (70% vs 46%, P = 0.003), but less likely to be the subject of a journal press release (17% vs 50%, P<0.001). Large RCTs that reported ‘hard’ outcomes did not attract an editorial more frequently than other studies (61% vs 58%, P>0.99), nor were they more likely to be the subject of a journal press release (14% vs 38%, P = 0.14). Conclusions The design of clinical studies whose results are published in high-impact medical journals is not associated with the likelihood or amount of ensuing news coverage. PMID:26701758

  13. The U.S. Government's Assistance to the AP's World-Wide Expansion: 1912-1948.

    ERIC Educational Resources Information Center

    Renaud-Komiya, Jean-Luc

    A study of the extent of the diplomatic and commercial assistance provided by the United States government to the Associated Press (AP) from 1912 to 1948 shows AP's manager, Kent Cooper, to be less a champion of the free press than an efficient captain of industry in expanding AP influence across the globe. Early in the twentieth century, British,…

  14. Pycnogenol Attenuates the Release of Proinflammatory Cytokines and Expression of Perilipin 2 in Lipopolysaccharide-Stimulated Microglia in Part via Inhibition of NF-κB and AP-1 Activation.

    PubMed

    Fan, Bin; Dun, Sai-Hong; Gu, Jian-Qiu; Guo, Yang; Ikuyama, Shoichiro

    2015-01-01

    Over activation of microglia results in the production of proinflammatory agents that have been implicated in various brain diseases. Pycnogenol is a patented extract from French maritime pine bark (Pinus pinaster Aiton) with strong antioxidant and anti-inflammatory potency. The present study investigated whether pycnogenol may be associated with the production of proinflammatory mediators in lipopolysaccharide-stimulated BV2 (mouse-derived) microglia. It was found that pycnogenol treatment was dose-dependently associated with significantly less release of nitricoxide (NO), TNF-α, IL-6 and IL-1β, and lower levels of intercellular adhesion molecule1 (ICAM-1) and perilipin 2 (PLIN2). Furthermore, this effect was replicated in primary brain microglia. Levels of inducible NO synthase mRNA and protein were attenuated, whereas there was no change in the production of the anti-inflammatory cytokine IL-10. Further evidence indicated that pycnogenol treatment led to the suppression of NF-κB activation through inhibition of p65 translocation into the nucleus and inhibited DNA binding of AP-1, suggesting that these proinflammatory factors are associated with NF-κB and AP-1. We conclude that pycnogenol exerts anti-inflammatory effects through inhibition of the NF-κB and AP-1pathway, and may be useful as a therapeutic agent in the prevention of diseases caused by over activation of microglia. PMID:26367267

  15. Pycnogenol Attenuates the Release of Proinflammatory Cytokines and Expression of Perilipin 2 in Lipopolysaccharide-Stimulated Microglia in Part via Inhibition of NF-κB and AP-1 Activation

    PubMed Central

    Fan, Bin; Dun, Sai-Hong; Gu, Jian-Qiu; Guo, Yang; Ikuyama, Shoichiro

    2015-01-01

    Over activation of microglia results in the production of proinflammatory agents that have been implicated in various brain diseases. Pycnogenol is a patented extract from French maritime pine bark (Pinus pinaster Aiton) with strong antioxidant and anti-inflammatory potency. The present study investigated whether pycnogenol may be associated with the production of proinflammatory mediators in lipopolysaccharide-stimulated BV2 (mouse-derived) microglia. It was found that pycnogenol treatment was dose-dependently associated with significantly less release of nitricoxide (NO), TNF-α, IL-6 and IL-1β, and lower levels of intercellular adhesion molecule1 (ICAM-1) and perilipin 2 (PLIN2). Furthermore, this effect was replicated in primary brain microglia. Levels of inducible NO synthase mRNA and protein were attenuated, whereas there was no change in the production of the anti-inflammatory cytokine IL-10. Further evidence indicated that pycnogenol treatment led to the suppression of NF-κB activation through inhibition of p65 translocation into the nucleus and inhibited DNA binding of AP-1, suggesting that these proinflammatory factors are associated with NF-κB and AP-1. We conclude that pycnogenol exerts anti-inflammatory effects through inhibition of the NF-κB and AP-1pathway, and may be useful as a therapeutic agent in the prevention of diseases caused by over activation of microglia. PMID:26367267

  16. Development of safety containment system for experiments on radioactive and other hazardous materials with large volume Paris-Edinburgh press at APS and first measurements on depleted-uranium

    NASA Astrophysics Data System (ADS)

    Jacobsen, Matthew; Velisavljevic, Nenad

    Recent technical developments using the large volume Paris-Edinburgh press platform have enabled x-ray synchrotron studies at high pressure and temperature conditions (Kono, Y. et al. Rev. Sci. Instrum. 83, 033905 (2012)). However, application for hazardous materials requires special handling due to safety issues, reactivity, or other challenges. Facility safety requirements require adequate containment for operation in the variety of environments available. In this talk, we will present a containment setup developed to enable studies of such materials. In particular, studies of the phase diagram of uranium using ultrasonic interferometry to determine the elasticity, mechanical, and thermal properties will be discussed. These results present the first high pressure studies of combined elasticity and thermal properties of depleted uranium metal as well as demonstration of a containment system for making such measurements.

  17. Press Start

    NASA Astrophysics Data System (ADS)

    Harteveld, Casper

    This level sets the stage for the design philosophy called “Triadic Game Design” (TGD). This design philosophy can be summarized with the following sentence: it takes two to tango, but it takes three to design a meaningful game or a game with a purpose. Before the philosophy is further explained, this level will first delve into what is meant by a meaningful game or a game with a purpose. Many terms and definitions have seen the light and in this book I will specifically orient at digital games that aim to have an effect beyond the context of the game itself. Subsequently, a historical overview is given of the usage of games with a serious purpose which starts from the moment we human beings started to walk on our feet till our contemporary society. It turns out that we have been using games for all kinds of non-entertainment purposes for already quite a long time. With this introductory material in the back of our minds, I will explain the concept of TGD by means of a puzzle. After that, the protagonist of this book, the game Levee Patroller, is introduced. Based on the development of this game, the idea of TGD, which stresses to balance three different worlds, the worlds of Reality, Meaning, and Play, came into being. Interested? Then I suggest to quickly “press start!”

  18. The Associated Press Stylebook and Libel Manual. Fully Updated and Revised.

    ERIC Educational Resources Information Center

    Goldstein, Norm, Ed.

    Pointing out that the style of the Associated Press (AP) defines clear writing, this revised edition of the practical and much-used AP stylebook is designed to be an essential handbook for all writers, editors, and students. The stylebook contains over 5000 entries laying out the AP's rules on grammar, spelling, punctuation, and usage. It gives…

  19. 17 CFR 230.135e - Offshore press conferences, meetings with issuer representatives conducted offshore, and press...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... RULES AND REGULATIONS, SECURITIES ACT OF 1933 General § 230.135e Offshore press conferences, meetings... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Offshore press conferences, meetings with issuer representatives conducted offshore, and press-related materials released offshore....

  20. The Global University Press

    ERIC Educational Resources Information Center

    Dougherty, Peter J.

    2012-01-01

    The modern world's understanding of American university press has long been shaped by university-press books. American university-press books are good international advertisements for the universities whose logos grace their spines. The growth of transnational scholarship and the expansion of digital communications networks are converging in ways…

  1. Report Nation March 2015 Press Release

    Cancer.gov

    For the first time, researchers have used national data to determine the incidence of the four major molecular subtypes of breast cancer by age, race/ethnicity, poverty level, and several other factors. The report showed continuing declines in cancer dea

  2. AP-Gate

    ERIC Educational Resources Information Center

    Whitman, Glenn

    2003-01-01

    In May 2001, students in the author's Advanced Placement (AP) United States History class were embroiled in a controversy surrounding the AP exam, in particular, having access to the exam's Document Based Question (DBQ) and free response portion prior to the test's administration. Prior to the exam, the College Board had provided a fifty-year time…

  3. Dry pressing technical ceramics

    SciTech Connect

    Lewis, W.A. Jr.

    1996-04-01

    Dry pressing of technical ceramics is a fundamental method of producing high-quality ceramic components. The goals of dry pressing technical ceramics are uniform compact size and green density, consistent part-to-part green density and defect-free compact. Dry pressing is the axial compaction of loosely granulated dry ceramic powders (< 3% free moisture) within a die/punch arrangement. The powder, under pressure, conforms to the specific shape of the punch faces and die. Powder compaction occurs within a rigid-walled die and usually between a top and bottom punch. Press configurations include anvil, rotary, multiple-punch and multiple-action.

  4. Early Telegraphic News Dispatches: The Forerunner of the AP.

    ERIC Educational Resources Information Center

    Schwarzlose, Richard A.

    The origin of the Associated Press (AP) lies in the early cooperative news gathering efforts of the editors of several New York newspapers. As early as May 1846, these editors were "pooling" their energies in response to newly developed modes of communication--the wire and wireless telegraph and the trans-oceanic steamship mail services. The…

  5. APS Science 2006.

    SciTech Connect

    Gibson, J. M.; Fenner, R. B.; Long, G.; Borland, M.; Decker, G.

    2007-05-24

    In my five years as the Director of the Advanced Photon Source (APS), I have been fortunate to see major growth in the scientific impact from the APS. This year I am particularly enthusiastic about prospects for our longer-term future. Every scientific instrument must remain at the cutting edge to flourish. Our plans for the next generation of APS--an APS upgrade--got seriously in gear this year with strong encouragement from our users and sponsors. The most promising avenue that has emerged is the energy-recovery linac (ERL) (see article on page xx), for which we are beginning serious R&D. The ERL{at}APS would offer revolutionary performance, especially for x-ray imaging and ultrafast science, while not seriously disrupting the existing user base. I am very proud of our accelerator physics and engineering staff, who not only keep the current APS at the forefront, but were able to greatly impress our international Machine Advisory Committee with the quality of their work on the possible upgrade option (see page xx). As we prepare for long-term major upgrades, our plans to develop and optimize all the sectors at APS in the near future are advancing. Several new beamlines saw first light this year, including a dedicated powder diffraction beamline (11-BM), two instruments for inelastic x-ray scattering at sector 30, and the Center for Nanoscale Materials (CNM) Nanoprobe beamline at sector 26. Our partnership in the first x-ray free-electron laser (LCLS) to be built at Stanford contributes to revolutionary growth in ultrafast science (see page xx), and we are developing a pulse chirping scheme to get ps pulses at sector 7 of the APS within a year or so. In this report, you will find selected highlights of scientific research at the APS from calendar year 2006. The highlighted work covers diverse disciplines, from fundamental to applied science. In the article on page xx you can see the direct impact of APS research on technology. Several new products have emerged from

  6. High School Press Pressures.

    ERIC Educational Resources Information Center

    Rogers, Luella P.

    History shows that the high school press suffers through cycles that reflect economic factors and cultural climates within communities, states, and the nation. The direction of that cycle in the 1960s and early 1970s was toward more open, free-flowing information by a vigorous student press, but those economic and cultural signs now are pointing…

  7. Lyndon Johnson's Press Conferences.

    ERIC Educational Resources Information Center

    Cooper, Stephen

    Because President Lyndon Johnson understood well the publicity value of the American news media, he sought to exploit them. He saw reporters as "torch bearers" for his programs and policies and used the presidential press conference chiefly for promotional purposes. Although he met with reporters often, his press conferences were usually…

  8. APS Science 2009.

    SciTech Connect

    Gibson, J. M; Mills, D. M.; Gerig, R.

    2010-05-01

    It is my pleasure to introduce the 2009 annual report of the Advanced Photon Source. This was a very good year for us. We operated with high reliability and availability, despite growing problems with obsolete systems, and our users produced a record output of publications. The number of user experiments increased by 14% from 2008 to more than 3600. We congratulate the recipients of the 2009 Nobel Prize in Chemistry-Venkatraman Ramakrishnan (Cambridge Institute for Medical Research), Thomas Steitz (Yale University), and Ada Yonath (Weizmann Institute) - who did a substantial amount of this work at APS beamlines. Thanks to the efforts of our users and staff, and the ongoing counsel of the APS Scientific Advisory Committee, we made major progress in advancing our planning for the upgrade of the APS (APS-U), producing a proposal that was positively reviewed. We hope to get formal approval in 2010 to begin the upgrade. With advocacy from our users and the support of our sponsor, the Office of Basic Energy Sciences in the Department of Energy (DOE) Office of Science, our operating budgets have grown to the level needed to more adequately staff our beamlines. We were also extremely fortunate to have received $7.9 M in American Recovery and Reinvestment Act ('stimulus') funding to acquire new detectors and improve several of our beamlines. The success of the new Linac Coherent Light Source at Stanford, the world's first x-ray free-electron laser, made us particularly proud since the undulators were designed and built by the APS. Among other highlights, we note that more than one-quarter of the 46 Energy Frontier Research Centers, funded competitively across the U.S. in 2009 by the DOE, included the Advanced Photon Source in their proposed work, which shows that synchrotron radiation, and the APS in particular, are central to energy research. While APS research covers everything from fundamental to applied science (reflected by the highlights in this report), the challenge

  9. The Associated Press Stylebook and Libel Manual. Fully Revised and Updated.

    ERIC Educational Resources Information Center

    Goldstein, Norm, Ed.

    Noting that more people write for The Associated Press (AP) than for any single newspaper in the world and that its style defines clear writing, this book presents more than 5000 entries that present AP's rules on grammar, spelling, punctuation and usage, with extra sections about reporting business and sports. The book, considered essential for…

  10. Letting The Nasa Press Engine Work For You

    NASA Astrophysics Data System (ADS)

    Weaver, Kimberly A.

    2006-09-01

    You have an amazing result based on NASA data or a NASA mission, you have written your seminal paper and submitted it to your favorite journal. You believe it has press potential and maybe you've even gotten help from your PR folks in writing a press release. Now you would really like NASA to issue this as a press release. But how do you do that? This presentation will illustrate the steps required to engage NASA in helping promote your story. What are NASA's requirements for newsworthiness? Should your news be released as a web feature story or in the local media? Does your news rise to the level of a full-blown press conference or will it be a media teleconference? How do you obtain approval for a NASA press event? Once your result is scheduled to be issued as a press release, how can you improve your chances of getting the best possible coverage for your story? I will discuss the NASA press process and suggest how to consider factors like timing, working with your collaborating institutions in an efficient way, and not letting the cat out of the bag until the press event.

  11. Press Conference with Elliot L. Richardson, Secretary of HEW.

    ERIC Educational Resources Information Center

    Department of Health, Education, and Welfare, Washington, DC.

    Two documents were released to the press on January 18, 1973, by Secretary Richardson, one summarizing his term of office as Secretary of Health, Education, and Welfare, and one reporting on HEW potential for the seventies (SO 005 666, SO 005 699). In an introductory statement prior to the press conference, the question of whether or not we as a…

  12. Trashing the Press.

    ERIC Educational Resources Information Center

    McMasters, Paul

    1994-01-01

    Discusses ominous assaults on press freedom on college campuses across the United States. Laments the lack of concern about First Amendment issues involved in these incidents, in which student newspapers have been stolen, trashed, and burned. (SR)

  13. Human Immunodeficiency Virus Type 2 (HIV-2) Gag Is Trafficked in an AP-3 and AP-5 Dependent Manner

    PubMed Central

    Alford, Justine E.; Marongiu, Michela; Watkins, Gemma L.

    2016-01-01

    Although human immunodeficiency virus (HIV) types 1 and 2 are closely related lentiviruses with similar replication cycles, HIV-2 infection is associated with slower progression to AIDS, a higher proportion of long term non-progressors, and lower rates of transmission than HIV-1, likely as a consequence of a lower viral load during HIV-2 infection. A mechanistic explanation for the differential viral load remains unclear but knowledge of differences in particle production between HIV-1 and HIV-2 may help to shed light on this issue. In contrast to HIV-1, little is known about the assembly of HIV-2 particles, and the trafficking of HIV-2 Gag, the structural component of the virus, within cells. We have established that HIV-2 Gag accumulates in intracellular CD63 positive compartments, from which it may be delivered or recycled to the cell surface, or degraded. HIV-2 particle release was dependent on the adaptor protein complex AP-3 and the newly identified AP-5 complex, but much less so on AP-1. In contrast, HIV-1 particle release required AP-1 and AP-3, but not AP-5. AP-2, an essential component of clathrin-mediated endocytosis, which was previously shown to be inhibitory to HIV-1 particle release, had no effect on HIV-2. The differential requirement for adaptor protein complexes confirmed that HIV-1 and HIV-2 Gag have distinct cellular trafficking pathways, and that HIV-2 particles may be more susceptible to degradation prior to release. PMID:27392064

  14. Influence of enteric citric acid on the release profile of 4-aminopyridine from HPMC matrix tablets.

    PubMed

    Martínez González, Ilona; Villafuerte Robles, Leopoldo

    2003-01-30

    A weakly basic experimental drug, 4-aminopyridine (4-AP), was taken as a model to study the influence of enteric citric acid (ECA) on the release profile from hydroxypropyl methylcellulose (HPMC) matrices, to set up a system bringing about gradual release of the drug. For this purpose, powder mixtures were wet granulated with water and compressed with a hydraulic press at 55 MPa. Dissolution studies were made using first 900 ml HCl 0.1 N, and then phosphate buffer pH 7.4. Dissolution curves were described by M(t)/M(inf)=kt(n). As physically expected, increasing proportions (2-9%) of the in acid insoluble ECA decreased the release rate. In an acid medium, ECA acts as a physical barrier obstructing the diffusion path, dissolving after the pH change to 7.4. Both circumstances flattening the release profile. Apparent zero order release was observed at ECA concentrations of about 10%. The presence of ECA compensates the effect of decreased solubility of 4-AP at pH 7.4. Unexpectedly, higher ECA proportions (10-50%) act increasing the dissolution rate. This is attributed to a void space formation around the insoluble ECA, after HPMC hydration, which percolates after a critical ECA proportion of approximately 10%. Moreover, decreasing release constant values (k) show a logarithmic relationship with increasing values of the exponent (n). This indicates that an apparent zero-order release can be obtained at a given release constant. PMID:12527188

  15. Advancing beyond AP Courses

    ERIC Educational Resources Information Center

    Hammond, Bruce G.

    2009-01-01

    A quiet revolution is picking up steam in the nation's private secondary schools, with broad implications for college admissions and for teaching and learning on both sides of the transition from high school to college. About 50 of the nation's leading college-preparatory schools have opted out of the College Board's Advanced Placement (AP)…

  16. APS power supply controls

    SciTech Connect

    Saunders, C.W.; Despe, O.D.

    1994-03-31

    The purpose of this document is to provide comprehensive coverage of the APS power supply control design. This includes application software, embedded controller software, networks, and hardware. The basic components will be introduced first, followed by the requirements driving the overall design. Subsequent sections will address each component of the design one by one. Latter sections will address specific applications.

  17. Building Reading, Writing and Analysis in the AP U.S. History Classroom

    ERIC Educational Resources Information Center

    Heller, Stephen; Stacy, Jason

    2013-01-01

    The building of historical thinking skills has historically been a lonely endeavor for AP U.S. history teachers. Many often generate their own pedagogy, perhaps modified from an AP workshop or generally gleaned from released exam essay questions. However, as currently scheduled, in 2014, the AP U.S. history exam will undergo a redesign that will…

  18. Press-On Optics

    ERIC Educational Resources Information Center

    Thorson, Jon C.

    1972-01-01

    The article discusses the design, application, and clinical uses of press-on optics which are descirbed as 1 millimeter thick, flexible lenses or prisms that may be produced in virtually any desired plus or minus dioptric power as ophthalmic lenses, or in any range of usable prism diopter power. (GW)

  19. Meet the Press

    ERIC Educational Resources Information Center

    Quick, Brian L.

    2004-01-01

    Objective: To field questions from a room of students simulating a press conference. Type of speech: Impromptu. Point value: 10 participation points. To receive all 10 points, students must (1) address three questions from the lectern and ask three questions from their seat (3 points), (2) respond thoroughly to each question by providing a…

  20. Optically Aligned Drill Press

    NASA Technical Reports Server (NTRS)

    Adderholdt, Bruce M.

    1994-01-01

    Precise drill press equipped with rotary-indexing microscope. Microscope and drill exchange places when turret rotated. Microscope axis first aligned over future hole, then rotated out of way so drill axis assumes its precise position. New procedure takes less time to locate drilling positions and produces more accurate results. Apparatus adapted to such other machine tools as milling and measuring machines.

  1. Drill Press Work Sample.

    ERIC Educational Resources Information Center

    Shawsheen Valley Regional Vocational-Technical High School, Billerica, MA.

    This manual contains a work sample intended to assess a handicapped student's interest in and to screen interested students into a training program in basic machine shop I. (The course is based on the entry level of the drill press operator.) Section 1 describes the assessment, correlates the work performed and worker traits required for…

  2. APS Science 2007.

    SciTech Connect

    Not Available

    2008-05-30

    This report provides research highlights from the Advanced Photon Source (APS). Although these highlights represent less than 10% of the published work from the APS in 2007, they give a flavor of the diversity and impact of user research at the facility. In the strategic planning the aim is to foster the growth of existing user communities and foresee new areas of research. This coming year finds the APS engaged in putting together, along with the users, a blueprint for the next five years, and making the case for a set of prioritized investments in beamlines, the accelerator, and infrastructure, each of which will be transformational in terms of scientific impact. As this is written plans are being formulated for an important user workshop on October 20-21, 2008, to prioritize strategic plans. The fruit from past investments can be seen in this report. Examples include the creation of a dedicated beamline for x-ray photon correlation spectroscopy at Sector 8, the evolution of dedicated high-energy x-ray scattering beamlines at sectors 1 and 11, a dedicated imaging beamline at Sector 32, and new beamlines for inelastic scattering and powder diffraction. A single-pulse facility has been built in collaboration with Sector 14 (BioCARS) and Phil Anfinrud at the National Institutes of Health, which will offer exceptionally high flux for single-pulse diffraction. The nanoprobe at Sector 26, built and operated jointly by the Argonne Center for Nanoscale Materials and the X-ray Operations and Research (XOR) section of the APS X-ray Science Division, has come on line to define the state of the art in nanoscience.

  3. Four Theories of the Press.

    ERIC Educational Resources Information Center

    Siebert, Fred S.; And Others

    A systematic understanding of the press requires an understanding of the social and political structures within which the press operates. This book discusses four theories that have determined the kind of press the Western world has had: authoritarian, libertarian, socially responsible, and Soviet communist. Each chapter discusses press…

  4. 55. QUARRY TILE CUTTERS, SECOND FLOOR, NORTH WING. WORKERS PRESSED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    55. QUARRY TILE CUTTERS, SECOND FLOOR, NORTH WING. WORKERS PRESSED THE CUTTERS INTO SLABS OF CLAY, LIFTED THEM ONTO DRYING BOARDS AND PRESSED THE PLUNGERS TO RELEASE THE CUT TILES. REPRODUCTIONS CUTTERS ARE NOT USED IN PRODUCTION. WOODEN FORMS FOR PRODUCING CLAY SLABS WITH ROLLING PINS REST AGAINST THE WALL. - Moravian Pottery & Tile Works, Southwest side of State Route 313 (Swamp Road), Northwest of East Court Street, Doylestown, Bucks County, PA

  5. AP-42 REVISION: COKE OVENS

    EPA Science Inventory

    The document "Compilation of Air Pollutant Emission Factors" (AP-42) has been published by the U. S. Environmental Protection Agency (EPA) since 1972. Supplements to AP-42 have been routinely published to add new emission source categories and to update existing emission factor...

  6. APS controls overview

    SciTech Connect

    1996-02-01

    The APS accelerator control system described in this report is a distributed system consisting of operator interfaces, a network, and interfaces to hardware. The operator interface is a UNIX-based workstation with an X-windows graphical user interface. The workstation may be located at any point on the facility network and maintain full functionality. The user has the ability to generate and alter control displays and to access the alarm handler, the archiver, interactive control programs, custom code, and other tools. The TCP/EP networking protocol has been selected as the underlying protocol for the control system network. TCP/EP is a commercial standard and readily available from network hardware vendors. Its implementation is independent of the particular network medium selected to implement the controls network. In the development environment copper Ethernet is the network medium; however, in the actual implementation a fiber-based system using hub technology will be utilized. The function of the network is to provide a generalized communication path between the host computers, operator workstations, input/output crates, and other hardware that comprise the control system.

  7. Final report for tank 241-AP-101, grab samples 1AP-95-1, 1AP-95-2, 1AP-95-3, 1AP-95-4, 1AP-95-5, and 1AP-95-6

    SciTech Connect

    Esch, R.A.

    1996-03-04

    Six supernate grab samples (1AP-95-1 through 6) and one field blank (1AP-95-7) were taken from tank 241-AP-101, on Nov. 10 and 13, 1995. Analyses were performed in support of the Safety Screening and the Waste Compatibility Safety programs. All analytical results were within the action limits stated in the TSAP.

  8. Thermal Decomposition Characteristics of Orthorhombic Ammonium Perchlorate (o-AP) and an 0-AP/HTPB-Based Propellant

    SciTech Connect

    BEHRENS JR.,RICHARD; MINIER,LEANNA M.G.

    1999-10-25

    A study to characterize the low-temperature reactive processes for o-AP and an AP/HTPB-based propellant (class 1.3) is being conducted in the laboratory using the techniques of simultaneous thermogravimetric modulated beam mass spectrometry (STMBMS) and scanning electron microscopy (SEM). The results presented in this paper are a follow up of the previous work that showed the overall decomposition to be complex and controlled by both physical and chemical processes. The decomposition is characterized by the occurrence of one major event that consumes up to {approx}35% of the AP, depending upon particle size, and leaves behind a porous agglomerate of AP. The major gaseous products released during this event include H{sub 2}O, O{sub 2}, Cl{sub 2}, N{sub 2}O and HCl. The recent efforts provide further insight into the decomposition processes for o-AP. The temporal behaviors of the gas formation rates (GFRs) for the products indicate that the major decomposition event consists of three chemical channels. The first and third channels are affected by the pressure in the reaction cell and occur at the surface or in the gas phase above the surface of the AP particles. The second channel is not affected by pressure and accounts for the solid-phase reactions characteristic of o-AP. The third channel involves the interactions of the decomposition products with the surface of the AP. SEM images of partially decomposed o-AP provide insight to how the morphology changes as the decomposition progresses. A conceptual model has been developed, based upon the STMBMS and SEM results, that provides a basic description of the processes. The thermal decomposition characteristics of the propellant are evaluated from the identities of the products and the temporal behaviors of their GFRs. First, the volatile components in the propellant evolve from the propellant as it is heated. Second, the hot AP (and HClO{sub 4}) at the AP-binder interface oxidize the binder through reactions that

  9. CIDER PRESS, LOOKING SOUTHEAST ACROSS THE SCHUYLKILL RIVER. THIS PRESS, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CIDER PRESS, LOOKING SOUTHEAST ACROSS THE SCHUYLKILL RIVER. THIS PRESS, CARVED OUT OF A LARGE BOULDER AT THE RIVERS EDGE, PROBABLY DATES FROM THE LIFETIME OF JOHN BARTRAM, IF NOT TO THE SWEDISH SETTLERS BEFORE HIM. THE IRON FENCE IS A NINETEENTH-CENTURY ADDITION - John Bartram House & Garden, 54th Street & Lindbergh Boulevard, Philadelphia, Philadelphia County, PA

  10. PRESS SHOP. SEVEN BLISS PRESSES STAMP OUT A VARIETY OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PRESS SHOP. SEVEN BLISS PRESSES STAMP OUT A VARIETY OF CARTRIDGE AND SHELL CASINGS. THIS DEPARTMENT WAS TRANSFORMED FROM A MONEY-LOSING OPERATION TO A PROFIT CENTER UNDER THE FIRST WORKER-MANAGED QUALITY CIRCLE IN THE PLANT. - American Brass Foundry, 70 Sayre Street, Buffalo, Erie County, NY

  11. The CIA and the Press.

    ERIC Educational Resources Information Center

    Carvalho, Bernardo A.

    The involvement of the Central Intelligence Agency (CIA) with both United States and foreign news media has been recorded in numerous publications. This report reviews the important aspects of the CIA-press relationships as they have appeared in print and discusses the implications of these relationsihps for the credibility of the press. Media…

  12. Press, Politics and Popular Government.

    ERIC Educational Resources Information Center

    Will, George F., Ed.

    A panel discussion on politics and the press was held at the convention of the American Political Science Association in September 1971. This volume contains an essay delivered at that panel on the various functions or activities of the press--adversary, surrogate, sovereign--and remarks of the three discussants. In addition, an essay especially…

  13. The Press Research Centre, 1956-1976.

    ERIC Educational Resources Information Center

    Press Research Centre, Krakow (Poland).

    In 1956, the Press Research Centre was established in Cracow, Poland by a group of journalists and publishers, for the purpose of instituting press research that would have practical applications. The aims of the Centre were to conduct studies on the history of the Polish press, the contemporary press, press readership, and editorial techniques.…

  14. Meet the APS Journal Editors

    NASA Astrophysics Data System (ADS)

    2016-05-01

    The Editors of the APS journals invite you to join them for conversation. The Editors will be available to answer questions, hear your ideas, and discuss any comments about the journals. All are welcome. Light refreshments will be served.

  15. Impacts of Information Subsidies and Community Structure on Local Press Coverage of Environmental Contamination.

    ERIC Educational Resources Information Center

    Griffin, Robert J.; Dunwoody, Sharon

    1995-01-01

    Finds that a press kit sent by an environmental group to midwestern newspapers influenced them to delegate local staff to cover the story. Indicates that the press's function to report or raise issues concerning industrial toxic releases and related health risks is tempered by community structure and particularly by community reliance on…

  16. Investing in a Large Stretch Press

    NASA Technical Reports Server (NTRS)

    Choate, M.; Nealson, W.; Jay, G.; Buss, W.

    1986-01-01

    Press for forming large aluminum parts from plates provides substantial economies. Study assessed advantages and disadvantages of investing in large stretch-forming press, and also developed procurement specification for press.

  17. Multicomponent Implant Releasing Dexamethasone

    NASA Astrophysics Data System (ADS)

    Nikkola, L.; Vapalahti, K.; Ashammakhi, N.

    2008-02-01

    Several inflammatory conditions are usually treated with corticosteroids. There are various problems like side effects with traditional applications of steroids, e.g. topical, or systemic routes. Local drug delivery systems have been studied and developed to gain more efficient administration with fewer side effects. Earlier, we reported on developing Dexamethasone (DX) releasing biodegradable fibers. However, their drug release properties were not satisfactory in terms of onset of drug release. Thus, we assessed the development of multicomponent (MC) implant to enhance earlier drug release from such biodegradable fibers. Poly (lactide-co-glycolide) (PLGA) and 2 wt-% and 8 wt-% DX were compounded and extruded with twin-screw extruder to form of fibers. Some of the fibers were sterilized to obtain a change in drug release properties. Four different fiber classes were studied: 2 wt-%, 8 wt-%, sterilized 2 wt-%, and sterilized 8 wt-%. 3×4 different DX-releasing fibers were then heat-pressed to form one multicomponent rod. Half of the rods where sterilized. Drug release was measured from initial fibers and multicomponent rods using a UV/VIS spectrometer. Shear strength and changes in viscosity were also measured. Drug release studies showed that drug release commenced earlier from multicomponent rods than from component fibers. Drug release from multicomponent rods lasted from day 30 to day 70. The release period of sterilized rods extended from day 23 to day 57. When compared to the original component fibers, the drug release from MC rods commenced earlier. The initial shear strength of MC rods was 135 MPa and decreased to 105 MPa during four weeks of immersion in phosphate buffer solution. Accordingly, heat pressing has a positive effect on drug release. After four weeks in hydrolysis, no disintegration was observed.

  18. APS Education and Diversity Efforts

    NASA Astrophysics Data System (ADS)

    Prestridge, Katherine; Hodapp, Theodore

    2015-11-01

    American Physical Society (APS) has a wide range of education and diversity programs and activities, including programs that improve physics education, increase diversity, provide outreach to the public, and impact public policy. We present the latest programs spearheaded by the Committee on the Status of Women in Physics (CSWP), with highlights from other diversity and education efforts. The CSWP is working to increase the fraction of women in physics, understand and implement solutions for gender-specific issues, enhance professional development opportunities for women in physics, and remedy issues that impact gender inequality in physics. The Conferences for Undergraduate Women in Physics, Professional Skills Development Workshops, and our new Professional Skills program for students and postdocs are all working towards meeting these goals. The CSWP also has site visit and conversation visit programs, where department chairs request that the APS assess the climate for women in their departments or facilitate climate discussions. APS also has two significant programs to increase participation by underrepresented minorities (URM). The newest program, the APS National Mentoring Community, is working to provide mentoring to URM undergraduates, and the APS Bridge Program is an established effort that is dramatically increasing the number of URM PhDs in physics.

  19. AP600 containment purge radiological analysis

    SciTech Connect

    O`Connor, M.; Schulz, J.; Tan, C.

    1995-02-01

    The AP600 Project is a passive pressurized water reactor power plant which is part of the Design Certification and First-of-a-Kind Engineering effort under the Advanced Light Water Reactor program. Included in this process is the design of the containment air filtration system which will be the subject of this paper. We will compare the practice used by previous plants with the AP600 approach to meet the goals of industry standards in sizing the containment air filtration system. The radiological aspects of design are of primary significance and will be the focus of this paper. The AP600 Project optimized the design to combine the functions of the high volumetric flow rate, low volumetric flow rate, and containment cleanup and other filtration systems into one multi-functional system. This achieves a more simplified, standardized, and lower cost design. Studies were performed to determine the possible concentrations of radioactive material in the containment atmosphere and the effectiveness of the purge system to keep concentrations within 10CFR20 limits and within offsite dose objectives. The concentrations were determined for various reactor coolant system leakage rates and containment purge modes of operation. The resultant concentrations were used to determine the containment accessibility during various stages of normal plant operation including refueling. The results of the parametric studies indicate that a dual train purge system with a capacity of 4,000 cfm per train is more than adequate to control the airborne radioactivity levels inside containment during normal plant operation and refueling, and satisfies the goals of ANSI/ANS-56.6-1986 and limits the amount of radioactive material released to the environment per ANSI/ANS 59.2-1985 to provide a safe environment for plant personnel and offsite residents.

  20. AP Human Geography and Success on the AP Test

    ERIC Educational Resources Information Center

    Roncone, John; Newhalfen, Nate

    2013-01-01

    Classroom projects that explore culture and globalization enhance the curriculum and help students see how geography directly connects to their lives. These authors contend that a project-based approach can supplement the teaching of an AP Human Geography course, and visualize this course as an essential tool for students to truly understand how…

  1. Planet Press: an EGU initiative to bring geoscientific research to children

    NASA Astrophysics Data System (ADS)

    Ferreira, Bárbara

    2016-04-01

    Planet Press (http://www.egu.eu/education/planet-press/) is an EGU educational project that aims to get children (mainly 7-13 year olds), as well as their parents and educators, interested in and engaged with up-to-date scientific research and news. Planet Press articles are short versions of EGU press releases written in child-friendly language. Because EGU press releases cover research published in the various EGU scientific journals, Planet Press focuses on topics as varied as air pollution, glaciers, climate change, earthquakes, ocean sciences, droughts and floods, or space sciences. The texts are reviewed by both scientists and educators to make sure they are accurate and clear to their target audience. By sharing new and exciting geoscientific research with young kids, we hope to inspire them to develop an interest in the Earth, planetary and space sciences. In this presentation, we describe how the Planet Press idea came about, how the project is run, and the challenges and lessons learnt since the launch of this educational initiative in 2014. Planet Press, which has the support of the EGU Committee on Education, is made possible by the work of volunteer scientists and educators who review and translate the texts. We are grateful for the help of Jane Robb, former EGU Educational Fellow, with launching the project. Planet Press is inspired by Space Scoop (http://www.spacescoop.org/), an initiative by UNAWE, the EU-Universe Awareness organisation, that brings astronomy news to children every week.

  2. Low Earth orbit assessment of proton anisotropy using AP8 and AP9 trapped proton models

    NASA Astrophysics Data System (ADS)

    Badavi, Francis F.; Walker, Steven A.; Santos Koos, Lindsey M.

    2015-04-01

    The completion of the International Space Station (ISS) in 2011 has provided the space research community with an ideal evaluation and testing facility for future long duration human activities in space. Ionized and secondary neutral particles radiation measurements inside ISS form the ideal tool for validation of radiation environmental models, nuclear reaction cross sections and transport codes. Studies using thermo-luminescent detectors (TLD), tissue equivalent proportional counter (TPEC), and computer aided design (CAD) models of early ISS configurations confirmed that, as input, computational dosimetry at low Earth orbit (LEO) requires an environmental model with directional (anisotropic) capability to properly describe the exposure of trapped protons within ISS. At LEO, ISS encounters exposure from trapped electrons, protons and geomagnetically attenuated galactic cosmic rays (GCR). For short duration studies at LEO, one can ignore trapped electrons and ever present GCR exposure contributions during quiet times. However, within the trapped proton field, a challenge arises from properly estimating the amount of proton exposure acquired. There exist a number of models to define the intensity of trapped particles. Among the established trapped models are the historic AE8/AP8, dating back to the 1980s and the recently released AE9/AP9/SPM. Since at LEO electrons have minimal exposure contribution to ISS, this work ignores the AE8 and AE9 components of the models and couples a measurement derived anisotropic trapped proton formalism to omnidirectional output from the AP8 and AP9 models, allowing the assessment of the differences between the two proton models. The assessment is done at a target point within the ISS-11A configuration (circa 2003) crew quarter (CQ) of Russian Zvezda service module (SM), during its ascending and descending nodes passes through the south Atlantic anomaly (SAA). The anisotropic formalism incorporates the contributions of proton narrow

  3. Low Earth orbit assessment of proton anisotropy using AP8 and AP9 trapped proton models.

    PubMed

    Badavi, Francis F; Walker, Steven A; Santos Koos, Lindsey M

    2015-04-01

    The completion of the International Space Station (ISS) in 2011 has provided the space research community with an ideal evaluation and testing facility for future long duration human activities in space. Ionized and secondary neutral particles radiation measurements inside ISS form the ideal tool for validation of radiation environmental models, nuclear reaction cross sections and transport codes. Studies using thermo-luminescent detectors (TLD), tissue equivalent proportional counter (TPEC), and computer aided design (CAD) models of early ISS configurations confirmed that, as input, computational dosimetry at low Earth orbit (LEO) requires an environmental model with directional (anisotropic) capability to properly describe the exposure of trapped protons within ISS. At LEO, ISS encounters exposure from trapped electrons, protons and geomagnetically attenuated galactic cosmic rays (GCR). For short duration studies at LEO, one can ignore trapped electrons and ever present GCR exposure contributions during quiet times. However, within the trapped proton field, a challenge arises from properly estimating the amount of proton exposure acquired. There exist a number of models to define the intensity of trapped particles. Among the established trapped models are the historic AE8/AP8, dating back to the 1980s and the recently released AE9/AP9/SPM. Since at LEO electrons have minimal exposure contribution to ISS, this work ignores the AE8 and AE9 components of the models and couples a measurement derived anisotropic trapped proton formalism to omnidirectional output from the AP8 and AP9 models, allowing the assessment of the differences between the two proton models. The assessment is done at a target point within the ISS-11A configuration (circa 2003) crew quarter (CQ) of Russian Zvezda service module (SM), during its ascending and descending nodes passes through the south Atlantic anomaly (SAA). The anisotropic formalism incorporates the contributions of proton narrow

  4. AP Geography, Environmental Science Thrive

    ERIC Educational Resources Information Center

    Robelen, Erik W.

    2012-01-01

    Geography may not be particularly known as a hot topic among today's students--even some advocates suggest it suffers from an image problem--but by at least one measure, the subject is starting to come into its own. Across more than 30 topics covered in the Advanced Placement (AP) program, participation in geography is rising faster than any…

  5. Coaching in the AP Classroom

    ERIC Educational Resources Information Center

    Fornaciari, Jim

    2013-01-01

    Many parallels exist between quality coaches and quality classroom teachers--especially AP teachers, who often feel the pressure to produce positive test results. Having developed a series of techniques and strategies for building a team-oriented winning culture on the field, Jim Fornaciari writes about how he adapted those methods to work in the…

  6. Apollo 13 Facts: Press Conference

    NASA Technical Reports Server (NTRS)

    2001-01-01

    Flight Director Gene Krantz gives an overview of the Apollo 13 mission as corrections are made in the power down checklist, passive thermal control, and orbital burns after the spacecraft runs into problems. He then answers questions from the press with the help of Tony England, Bill Peters, and Dick Thorson. Footage then shows newspaper headlines 'We're Not Concerned' and 'Getting Ready to Land' as people watch televisions to see if the astronauts landed safely. The press conference section of this video has sound, the headlines section does not.

  7. ASSESSING CHEMICAL RELEASES AND WORKER EXPOSURES FROM A FILTERPRESS

    EPA Science Inventory

    Chemical releases and worker exposures associated with the filtration of an industrial wastewater sludge were characterized. The filter was a recessed chamber filter press with an open filtrate discharge system. Chemical releases and worker exposures for a selected chemical were ...

  8. Gifted Education Press Quarterly, 1995.

    ERIC Educational Resources Information Center

    Fisher, Maurice D., Ed.

    1995-01-01

    This document consists of the four issues of the newsletter "Gifted Education Press Quarterly" published during 1995. This newsletter addresses issues in the education of gifted children and youth. The major articles are: (1) "Using Today's Technology: Parents Can Help Challenge Gifted Children" (Adrienne O'Neill); (2) "Outcomes-Based Education…

  9. Law and the Student Press.

    ERIC Educational Resources Information Center

    Stevens, George E.; Webster, John B.

    Court cases and legal decisions involving the student press in the late 1960s and early 1970s are brought together in this book in order to show how the law has been applied to school officials and student journalists in high school, college, and the underground. The ten chapters cover the following topics: censorship, libel, obscenity, contempt,…

  10. NATIONAL ACADEMY PRESS WEB SITE

    EPA Science Inventory

    The National Academy Press is the publisher for the National Academy of Sciences, the National Academy of Engineering, the Institute of Medicine, and the National Research Council. Through this web site, you have access to a virtual treasure trove of books, reports and publicatio...

  11. 30th Arniversary Press Conference

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Marking the occasion of the Apollo 11 30th Anniversary, members of the Apollo and Saturn astronaut programs attended festivities at Marshall Space Flight Center in Huntsville, AL. A press conference was held at the U. S. Space and Rocket Center for the visiting astronauts. Pictured are (L/R): Edgar Mitchell, Walt Cunningham, Charlie Duke, Buzz Aldrin, Dick Gordon and Owen Garriott.

  12. An Investigation into Managers' Language Use in Earnings Press Releases

    ERIC Educational Resources Information Center

    Riley, Tracey Jean

    2011-01-01

    For years, researchers have examined financial data in corporate earnings announcements and their influence on market participants. More recently, a body of research has been developing recognizing the impact of narrative disclosures and managers' deliberate language choices. However, no prior studies have investigated those language choices of…

  13. The APS control system network

    SciTech Connect

    Sidorowicz, K.V.; McDowell, W.P.

    1995-12-31

    The APS accelerator control system is a distributed system consisting of operator interfaces, a network, and computer-controlled interfaces to hardware. This implementation of a control system has come to be called the {open_quotes}Standard Model.{close_quotes} The operator interface is a UNDC-based workstation with an X-windows graphical user interface. The workstation may be located at any point on the facility network and maintain full functionality. The function of the network is to provide a generalized communication path between the host computers, operator workstations, input/output crates, and other hardware that comprise the control system. The crate or input/output controller (IOC) provides direct control and input/output interfaces for each accelerator subsystem. The network is an integral part of all modem control systems and network performance will determine many characteristics of a control system. This paper will describe the overall APS network and examine the APS control system network in detail. Metrics are provided on the performance of the system under various conditions.

  14. An AP Calculus Classroom Amusement Park

    ERIC Educational Resources Information Center

    Ferguson, Sarah

    2016-01-01

    Throughout the school year, AP Calculus teachers strive to teach course content comprehensively and swiftly in an effort to finish all required material before the AP Calculus exam. As early May approaches and the AP Calculus test looms, students and teachers nervously complete lessons, assignments, and assessments to ensure student preparation.…

  15. Preparing Students for the AP Psychology Exam

    ERIC Educational Resources Information Center

    Whitlock, Kristin

    2013-01-01

    The Advanced Placement Psychology exam is one of the fastest growing exams offered by the College Board. The average percent of change in the number of students taking this exam over the past five years is 12.4%. With 238,962 students taking the exam in 2013, the AP Psychology exam is the sixth largest exam, surpassing AP Biology and AP World…

  16. Managing Weeds in Potato Health Management, ed. D. Johnson. APS Press

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Weeds must be managed throughout the entire crop rotation to optimize potato tuber yield and quality. Understanding factors that promote weed species and allow them to persist in crop rotations is key to designing cropping systems that discourage and reduce the impact of weeds. Weeds can be best man...

  17. Managing Pesticide Resistance in Potato Health Management, ed. D. Johnson. APS Press

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Pesticides exert a selection pressure on pest populations and pests that are not controlled may produce progeny with genetic resistance to the pesticide. Pesticide classification systems based on site/mode of action have been developed and knowing a pesticides’s mode/site of action is key to planni...

  18. Applying Pesticides in Potato Health Management, ed. D. Johnson. APS Press

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Pesticides are an important component of most management programs for nematodes, diseases, weeds, and insects that impact yield and/or quality in potatoes. The appropriate pesticide, correct timing of application, effective rate, and appropriate method of application must be selected for effective p...

  19. Hot isostatic pressing of ceramics

    NASA Technical Reports Server (NTRS)

    Honma, K.

    1985-01-01

    A mixture containing glass 70 to 95 and BN or B4C powder (0.1-10 microns) 5 to 30 vol. % is used as a secondary pressure medium in hot isostatic pressing of ceramics. Thus, Pyrex beads were mixed with 15% vol. BN powder (average diameter 2 microns), fused at 1400 deg for 2 h, cooled, crushed, and put into a graphite crucible. A Si3N4 sintered body was embedded in the powder, heated in vacuum at 1200 deg for 2 h, treated in a hot isostatic press furnace at 1700 deg and 1000 atm. for 1 h, and cooled to give a Si3N4 ceramic. It was easily separated from the crucible.

  20. A Conversation with Frank Press

    NASA Astrophysics Data System (ADS)

    Goodstein, Judith R.

    Geophysicist Frank Press was director of Caltech's Seismological Laboratory from 1957 to 1965. In this interview, he recalls his work with Maurice Ewing at Columbia's Lamont Geological Observatory; his directorship of Caltech's Seismological Laboratory and colleagues Charles Richter, Beno Gutenberg, and Hugo Benioff; his work on the free oscillations of the earth; and his part in establishing the worldwide network of seismographs for the detection of nuclear weapons testing.

  1. Radial Electromagnetic Press for IGNITOR

    NASA Astrophysics Data System (ADS)

    Cucchiaro, A.; Anzidei, L.; Capriccioli, A.; Celentano, G.; Crescenzi, C.; Gasparotto, M.; Guerrieri, A.; Pizzuto, A.; Palmieri, A.; Rita, C.; Roccella, M.; Coppi, B.

    1998-11-01

    The structural performance of the IGNITOR machine relies upon a combination of both bucking between Toroidal Field Coils (TFCs), Central Solenoid (CS) and the Central Post (CP), and wedging in a well-defined area of the TFCs and of the magnet mechanical structure (called C-Clamps). This requires a pre-loading system to enhance the load bearing capability. Several solutions have been assessed and compared with each other within the operational scenarios and eventually a radial electromagnetic press has been selected as reference(Pizzuto A. et al., ENEA Report IGN/MAC/001/96). The loading system is made up by active coils and passive restraining rings. The radial active press consists of two pairs of coils (200x200mm each), symmetrically located relative to the machine equatorial plane and seating onto the passive rings. The permanent pre--load of the rings is applied through a wedging system with a load of about 120 MN. A radial electromagnetic press has the purpose of modulating the axial pressure on the TFC inner legs during the pulse. Design aspects including stress analysis, manufacturing, assembly and operational scenarios of the selected solution are presented in this paper.

  2. AP reclamation and reuse in RSRM propellant

    NASA Technical Reports Server (NTRS)

    Miks, Kathryn F.; Harris, Stacey A.

    1995-01-01

    A solid propellant ingredient reclamation pilot plant has been evaluated at the Strategic Operations of Thiokol Corporation, located in Brigham City, Utah. The plant produces AP wet cake (95 percent AP, 5 percent water) for recycling at AP vendors. AP has been obtained from two standard propellant binder systems (PBAN and HTPB). Analytical work conducted at Thiokol indicates that the vendor-recrystallized AP meets Space Shuttle propellant specification requirements. Thiokol has processed 1-, 5-, and 600-gallon propellant mixes with the recrystallized AP. Processing, cast, cure, ballistic, mechanical, and safety properties have been evaluated. Phillips Laboratory static-test-fired 70-pound and 800-pound BATES motors. The data indicate that propellant processed with reclaimed AP has nominal properties.

  3. The Small Book Press: A Cultural Essential.

    ERIC Educational Resources Information Center

    Henderson, Bill

    1984-01-01

    Discussion of small literary book publishers notes works of small-press authors (Thomas Paine, Washington Irving, Walt Whitman, Mark Twain, Upton Sinclair, Anais Nin); today's outstanding presses (Creative Arts Book Company, Persea Books, Full Court Press, Reed and Cannon Company, Tuumba Books); and role of little magazines. Thirty-seven…

  4. Yale University Press: Disseminating "Lux et Veritas"?

    ERIC Educational Resources Information Center

    Parrott, John B.

    2010-01-01

    America's university presses are situated within a network of over one hundred universities, learned societies, and scholarly associations. According to a pamphlet put out by the American Association of University Presses, these presses "make available to the broader public the full range and value of research generated by university faculty."…

  5. The Burger Court and the Press.

    ERIC Educational Resources Information Center

    Higdon, Philip R.

    This report discusses recent cases involving freedom of the press that have been heard before the Burger court of the United States Supreme Court. The report discerns a trend toward treating the press like an ordinary citizen; this is a reversal of the view of the Warren court that the First Amendment creates special rights for the press so that…

  6. Pyrometry in the Multianvil Press: New approach for temperature measurement in large volume press experiments

    NASA Astrophysics Data System (ADS)

    Sanehira, T.; Wang, Y.; Prakapenka, V.; Rivers, M. L.

    2008-12-01

    Temperature measurement in large volume press experiments has been based on thermocouple emf, which has well known problems: unknown pressure dependence of emf [e.g., 1], chemical reaction between thermocouple and other materials, deformation related texture development in the thermocouple wires [2], and so on. Thus, different techniques to measure temperatures in large volume press experiments other than thermocouples are required to measure accurate temperatures under high pressures. Here we report a new development using pyrometry in the multianvil press, where temperatures are derived on the basis of spectral radiometry. Several high pressure runs were conducted using the 1000 ton press with a DIA module installed at 13 ID-D GSECARS beamline at Advanced Photon Source (APS) [3]. The cubic pressure medium, 14 mm edge length, was made of soft-fired pyrophyllite with a graphite furnace. A moissanite (SiC) single crystal was built inside the pressure medium as a window for the thermal emission signal to go through. An MgO disk with 1.0 mm thickness was inserted in a gap between the top of the SiC crystal and thermocouple hot junction. The bottom of the window crystal was in direct contact with the tip of the anvil, which had a 1.5 mm diameter hole drilled all the way through the anvil axis. An optical fiber was inserted in this hole and the open end of fiber was in contact with the SiC crystal. Thermal spectral radiance from the inner cell assembly was obtained via the fiber and recorded by an Ocean Optics HP2000 spectrometer. The system response of spectrometer was calibrated by a tungsten ribbon ramp (OL550S, Optronic Laboratories, Inc.) with standard of spectral radiance. The cell assembly was compressed up to target value of 15 tons and then temperature was increased up to 1573 K. Radiation spectra were mainly obtained above 873 K and typical integration time was 1 ms or 10 ms. Data collection was done in the process of increase and decrease of temperature. In

  7. APS high heat load monochromator

    SciTech Connect

    Lee, W.K.; Mills, D.

    1993-02-01

    This document contains the design specifications of the APS high heat load (HHL) monochromator and associated accessories as of February 1993. It should be noted that work is continuing on many parts of the monochromator including the mechanical design, crystal cooling designs, etc. Where appropriate, we have tried to add supporting documentation, references to published papers, and calculations from which we based our decisions. The underlying philosophy behind performance specifications of this monochromator was to fabricate a device that would be useful to as many APS users as possible, that is, the design should be as generic as possible. In other words, we believe that this design will be capable of operating on both bending magnet and ID beamlines (with the appropriate changes to the cooling and crystals) with both flat and inclined crystal geometries and with a variety of coolants. It was strongly felt that this monochromator should have good energy scanning capabilities over the classical energy range of about 4 to 20 keywith Si (111) crystals. For this reason, a design incorporating one rotation stage to drive both the first and second crystals was considered most promising. Separate rotary stages for the first and second crystals can sometimes provide more flexibility in their capacities to carry heavy loads (for heavily cooled first crystals or sagittal benders of second crystals), but their tuning capabilities were considered inferior to the single axis approach.

  8. Tank 241-AP-106, Grab samples, 6AP-98-1, 6AP-98-2 and 6AP-98-3 Analytical results for the final report

    SciTech Connect

    FULLER, R.K.

    1999-02-23

    This document is the final report for tank 241-AP-106 grab samples. Three grab samples 6AP-98-1, 6AP-98-2 and 6AP-98-3 were taken from riser 1 of tank 241-AP-106 on May 28, 1998 and received by the 222-S Laboratory on May 28, 1998. Analyses were performed in accordance with the ''Compatability Grab Sampling and Analysis Plan'' (TSAP) (Sasaki, 1998) and the ''Data Quality Objectives for Tank Farms Waste Compatability Program (DQO). The analytical results are presented in the data summary report. No notification limits were exceeded. The request for sample analysis received for AP-106 indicated that the samples were polychlorinated biphenyl (PCB) suspects. The results of this analysis indicated that no PCBs were present at the Toxic Substance Control Act (TSCA) regulated limit of 50 ppm. The results and raw data for the PCB analysis are included in this document.

  9. In vitro dissolution and in vivo gamma scintigraphic evaluation of press-coated salbutamol sulfate tablets.

    PubMed

    Li, Wei; Shi, Cai-Hong; Sheng, Yi-Ling; Cui, Ping; Zhao, Yu-Qing; Zhang, Xiang-Rong

    2013-12-01

    The aim of this study was to investigate the in vitro and in vivo performance of salbutamol sulfate press-coated tablets for delayed release. The in vitro release behavior of press-coated tablets with the outer layer of PEG 6000/ Eudragit S100 blends (2:1) in pH 1.2 (0.1 mol L-1 HCl) and then pH 6.8 buffer solution was examined. Morphological change of the press-coated tablet during in vitro release was recorded with a digital camera. Release of salbutamol sulfate from press-coated tablets was less than 5 % before 3 h and was completed after 8 h in pH 6.8 phosphate buffer solution. In vivo gamma scintigraphy study carried out on healthy men indicated that the designed system released the drug in lower parts of the GI tract after a lag time of 5 hours. The results showed the capability of the system of achieving delayed release of the drug in both in vitro and in vivo gamma scintigraphy studies. PMID:24451078

  10. Current status and approaches to developing press-coated chronodelivery drug systems.

    PubMed

    Lin, Shan-Yang; Kawashima, Yoshiaki

    2012-02-10

    The past several decades have seen the development of many controlled-release preparations featuring constant release rates to maintain drug concentrations in the human body, regardless of the patient's physiological condition. However, long-term constant drug concentrations in the blood and tissue can cause problems such as resistance, tolerability, and drug side effects. People vary considerably in their physiological and biochemical conditions during any 24 h period, due to the circadian rhythm, and thus, the constant delivery of a drug into the body seems both unnecessary and undesirable. If the drug release profile mimics a living system's pulsatile hormone secretion, then it may improve drug efficacy, and reduce the toxicity of a specific drug administration schedule. Medication and treatments provided according to the body's circadian rhythms will result in better outcomes. This may be provided by a chronopharmaceutical dosage regimen with pulsatile release that matches the circadian rhythm resulting from a disease state, so optimizing the therapeutic effect while minimizing side effects. The press coating technique is a simple and unique technology used to provide tablets with a programmable lag phase, followed by a fast, or rate-controlled, drug release after administration. The technique offers many advantages, and no special coating solvent or coating equipment is required for manufacturing this type of tablet. The present review article introduces chronopharmaceutical press-coated products from a patient physiological needs perspective. The contents of this article include biological rhythms and pulsatile hormone secretion in humans, the reasons for using pulsatile drug delivery for disease treatment, recent chronopharmaceutical preparations appearing on the market, updated compilation of all research articles and press-coated delivery techniques, factors affecting the performance and drug release characteristics of press-coated delivery systems, and

  11. Improving Dryer and Press Efficiencies Through Combustion of Hydrocarbon Emissions

    SciTech Connect

    Sujit Banerjee

    2005-10-31

    Emission control devices on dryers and presses have been legislated into the industry, and are now an integral part of the drying system. These devices consume large quantities of natural gas and electricity and down-sizing or eliminating them will provide major energy savings. The principal strategy taken here focuses on developing process changes that should minimize (and in some cases eliminate) the need for controls. A second approach is to develop lower-cost control options. It has been shown in laboratory and full-scale work that Hazardous Air Pollutants (HAPs) emerge mainly at the end of the press cycle for particleboard, and, by extension, to other prod-ucts. Hence, only the air associated with this point of the cycle need be captured and treated. A model for estimating terpene emissions in the various zones of veneer dryers has been developed. This should allow the emissions to be concentrated in some zones and minimized in others, so that some of the air could be directly released without controls. Low-cost catalysts have been developed for controlling HAPs from dryers and presses. Catalysts conventionally used for regenerative catalytic oxidizers can be used at much lower temperatures for treating press emissions. Fluidized wood ash is an especially inexpensive mate-rial for efficiently reducing formaldehyde in dryer emissions. A heat transfer model for estimating pinene emissions from hot-pressing strand for the manufacture of flakeboard has been constructed from first principles and validated. The model shows that most of the emissions originate from the 1-mm layer of wood adjoining the platen surface. Hence, a simple control option is to surface a softwood mat with a layer of hardwood prior to pressing. Fines release a disproportionate large quantity of HAPs, and it has been shown both theo-retically and in full-scale work that particles smaller than 400 µm are principally responsible. Georgia-Pacific is considering green

  12. Cold press sintering of simulated lunar basalt

    NASA Technical Reports Server (NTRS)

    Altemir, D. A.

    1993-01-01

    In order to predict the conditions for which the lunar regolith may be adequately sintered, experiments were conducted in which samples of simulated lunar basalt (MLS-1) were pressed at high pressures and then heated in an electric furnace. This sintering process may be referred to as cold press sintering since the material is pressed at room temperature. Although test articles were produced which possessed compressive strengths comparable to that of terrestrial concrete, the cold press sintering process requires very high press pressures and sintering temperatures in order to achieve that strength. Additionally, the prospect of poor internal heat transfer adversely affecting the quality of sintered lunar material is a major concern. Therefore, it is concluded that cold press sintering will most likely be undesirable for the production of lunar construction materials.

  13. Slurry-pressing consolidation of silicon nitride

    NASA Technical Reports Server (NTRS)

    Sanders, William A.; Kiser, James D.; Freedman, Marc R.

    1989-01-01

    A baseline slurry-pressing method for a silicon nitride material is developed. The Si3N4 composition contained 5.8 wt percent SiO2 and 6.4 wt percent Y2O3. Slurry-pressing variables included volume percent solids, application of ultrasonic energy, and pH. Twenty vol percent slurry-pressed material was approximately 11 percent stronger than both 30 vol percent slurry-pressed and dry-pressed materials. The Student's t-test showed the difference to be significant at the 99 percent confidence level. Twenty volume percent (300 h) slurry-pressed test bars exhibited strengths as high as 980 MPa. Large, columnar beta-Si3N4 grains caused failure in the highest strength specimens. The improved strength correlated with better structural uniformity as determined by radiography, optical microscopy, and image analysis.

  14. Slurry-pressing consolidation of silicon nitride

    NASA Technical Reports Server (NTRS)

    Sanders, William A.; Kiser, James D.; Freedman, Marc R.

    1988-01-01

    A baseline slurry-pressing method for a silicon nitride material is developed. The Si3N4 composition contained 5.8 wt percent SiO2 and 6.4 wt percent Y2O3. Slurry-pressing variables included volume percent solids, application of ultrasonic energy, and pH. Twenty vol percent slurry-pressed material was approximately 11 percent stronger than both 30 vol percent slurry-pressed and dry-pressed materials. The Student's t-test showed the difference to be significant at the 99 percent confidence level. Twenty volume percent (300 h) slurry-pressed test bars exhibited strengths as high as 980 MPa. Large, columnar beta-Si3N4 grains caused failure in the highest strength specimens. The improved strength correlated with better structural uniformity as determined by radiography, optical microscopy, and image analysis.

  15. ELECTROCHEMICAL CORROSION TESTING OF TANKS 241-AN-102 & 241-AP-107 & 241-AP-108 IN SUPPORT OF ULTRASONIC TESTING

    SciTech Connect

    WYRWAS RB; DUNCAN JB

    2008-11-20

    This report presents the results of the corrosion rates that were measured using electrochemical methods for tanks 241-AN-102 (AN-102), 241-AP-107 (AP 107), and 241-AP-108 (AP-108) performed under test plant RPP-PLAN-38215. The steel used as materials of construction for AN and AP tank farms was A537 Class 1. Test coupons of A537 Class 1 carbon steel were used for corrosion testing in the AN-107, AP-107, and AP-108 tank waste. Supernate will be tested from AN-102, AP-107, and Ap-108. Saltcake testing was performed on AP-108 only.

  16. NASA/MSFC Large Stretch Press Study

    NASA Technical Reports Server (NTRS)

    Choate, M. W.; Nealson, W. P.; Jay, G. C.; Buss, W. D.

    1985-01-01

    The purpose of this study was to: A. assess and document the advantages/disadvantages of a government agency investment in a large stretch form press on the order of 5000 tons capacity (per jaw); B. develop a procurement specification for the press; and C. provide trade study data that will permit an optimum site location. Tasks were separated into four major elements: cost study, user survey, site selection, and press design/procurement specification.

  17. Coaching Strategies for AP: Building a Successful AP European History Program

    ERIC Educational Resources Information Center

    Fornaciari, Jim

    2014-01-01

    The October 2013 special issue of "Social Education" dealt with almost all AP social studies subjects, but omitted AP European History. This is one of the most fascinating AP subjects for students and teachers alike. In this article, the author shares his experiences since hewas given the responsibility of building his school's…

  18. AP Music Theory in Your School.

    ERIC Educational Resources Information Center

    Lucia, Raymond

    1993-01-01

    Asserts that an Advanced Placement (AP) course in music theory offers student musicians opportunities to gain new insight into melody, harmony, and structure. Describes content and teaching methods used in an AP music theory program. Discusses necessary teacher characteristics and maintains that both students and teachers benefit from the course.…

  19. Toward lattice QCD simulation on AP1000

    NASA Astrophysics Data System (ADS)

    Ohta, Shigemi

    AP1000 is Fujitsu Laboratory's experimental parallel computer consisting of up to 1024 microcomputers called cells. It is found that each AP1000 cell can sustain two to three megaflops computational speed for full QCD lattice numerical simulations in IEEE 64-bit floating point format

  20. AP-42 ADDITIONS AND REVISIONS - WILDLAND FIRES

    EPA Science Inventory

    This project is aimed at consolidating, selecting, and disseminating the most appropriate data and methods for estimating air emissions from wildfires and prescribed burns. The product will replace a current section of AP-42, but may not take the precise form of an AP-42 secti...

  1. Advanced APS impacts on vehicle payloads

    NASA Astrophysics Data System (ADS)

    Schneider, Steven J.; Reed, Brian D.

    1989-04-01

    Advanced auxiliary propulsion system (APS) technology has the potential to both, increase the payload capability of earth-to-orbit (ETO) vehicles by reducing APS propellant mass, and simplify ground operations and logistics by reducing the number of fluids on the vehicle and eliminating toxic, corrosive propellants. The impact of integrated cryogenic APS on vehicle payloads is addressed. In this system, launch propulsion system residuals are scavenged from integral launch propulsion tanks for use in the APS. Sufficient propellant is preloaded into the APS to return to earth with margin and noncomplete scavenging assumed. No propellant conditioning is required by the APS, but ambient heat soak is accommodated. High temperature rocket materials enable the use of the unconditioned hydrogen/oxygen in the APS and are estimated to give APS rockets specific impulse of up to about 444 sec. The payload benefits are quantified and compared with an uprated monomethylhydrazine/nitrogen tetroxide system in a conservative fashion, by assuming a 25.5 percent weight growth for the hydrogen/oxygen system and a 0 percent weight growth for the uprated system. The combination of scavenging and high performance gives payload impacts which are highly mission specific. A payload benefit of 861 kg (1898 lbm) was estimated for a Space Station Freedom rendezvous mission and 2099 kg (4626 lbm) for a sortie mission, with payload impacts varying with the amount of launch propulsion residual propellants. Missions without liquid propellant scavenging were estimated to have payload penalties, however, operational benefits were still possible.

  2. AP Courses Get Audited for Quality

    ERIC Educational Resources Information Center

    Ashford, Ellie

    2007-01-01

    As the college admissions process has gotten much more competitive, the number of high school students taking Advanced Placement (AP) courses has soared. At the same time, policymakers and education leaders seek to get more minorities and students not on the college track to sign up for AP and other rigorous classes. But as high schools have…

  3. Advanced APS Impacts on Vehicle Payloads

    NASA Technical Reports Server (NTRS)

    Schneider, Steven J.; Reed, Brian D.

    1989-01-01

    Advanced auxiliary propulsion system (APS) technology has the potential to both, increase the payload capability of earth-to-orbit (ETO) vehicles by reducing APS propellant mass, and simplify ground operations and logistics by reducing the number of fluids on the vehicle and eliminating toxic, corrosive propellants. The impact of integrated cryogenic APS on vehicle payloads is addressed. In this system, launch propulsion system residuals are scavenged from integral launch propulsion tanks for use in the APS. Sufficient propellant is preloaded into the APS to return to earth with margin and noncomplete scavenging assumed. No propellant conditioning is required by the APS, but ambient heat soak is accommodated. High temperature rocket materials enable the use of the unconditioned hydrogen/oxygen in the APS and are estimated to give APS rockets specific impulse of up to about 444 sec. The payload benefits are quantified and compared with an uprated monomethyl hydrazine/nitrogen tetroxide system in a conservative fashion, by assuming a 25.5 percent weight growth for the hydrogen/oxygen system and a 0 percent weight growth for the uprated system. The combination and scavenging and high performance gives payload impacts which are highly mission specific. A payload benefit of 861 kg (1898 lbm) was estimated for a Space Station Freedom rendezvous mission and 2099 kg (4626 lbm) for a sortie mission, with payload impacts varying with the amount of launch propulsion residual propellants. Missions without liquid propellant scavenging were estimated to have payload penalties, however, operational benefits were still possible.

  4. Advanced APS impacts on vehicle payloads

    NASA Technical Reports Server (NTRS)

    Schneider, Steven J.; Reed, Brian D.

    1989-01-01

    Advanced auxiliary propulsion system (APS) technology has the potential to both, increase the payload capability of earth-to-orbit (ETO) vehicles by reducing APS propellant mass, and simplify ground operations and logistics by reducing the number of fluids on the vehicle and eliminating toxic, corrosive propellants. The impact of integrated cryogenic APS on vehicle payloads is addressed. In this system, launch propulsion system residuals are scavenged from integral launch propulsion tanks for use in the APS. Sufficient propellant is preloaded into the APS to return to earth with margin and noncomplete scavenging assumed. No propellant conditioning is required by the APS, but ambient heat soak is accommodated. High temperature rocket materials enable the use of the unconditioned hydrogen/oxygen in the APS and are estimated to give APS rockets specific impulse of up to about 444 sec. The payload benefits are quantified and compared with an uprated monomethylhydrazine/nitrogen tetroxide system in a conservative fashion, by assuming a 25.5 percent weight growth for the hydrogen/oxygen system and a 0 percent weight growth for the uprated system. The combination of scavenging and high performance gives payload impacts which are highly mission specific. A payload benefit of 861 kg (1898 lbm) was estimated for a Space Station Freedom rendezvous mission and 2099 kg (4626 lbm) for a sortie mission, with payload impacts varying with the amount of launch propulsion residual propellants. Missions without liquid propellant scavenging were estimated to have payload penalties, however, operational benefits were still possible.

  5. The status of APS, BESSRC, and NEET.

    SciTech Connect

    Ahmad, I.; Dunford, R. W.; Esbensen, H.; Gemmell, D. S.; Kanter, E. P.; Kraessig, B.; Rutt, U.; Southworth, S. H.

    1999-03-10

    We present a brief summary of the current status of the Advanced Photon Source (APS) at Argonne National Laboratory and of the facilities at two of the APS sectors operated by the Basic Energy Sciences Synchrotrons Radiation Center (BESSRC). This is followed by a report on recent measurements at BESSRC on the phenomenon of Nuclear Excitation by Electronic Transition (NEET).

  6. AP1S3 is required for hepatitis C virus infection by stabilizing E2 protein.

    PubMed

    Li, Xiang; Niu, Yuqiang; Cheng, Min; Chi, Xiaojing; Liu, Xiuying; Yang, Wei

    2016-07-01

    Hepatitis C virus (HCV) infects 130 million people worldwide and is a leading cause of liver cirrhosis, end-stage liver disease and hepatocellular carcinoma. The interactions between viral elements and host factors play critical role on HCV invade, replication and release. Here, we identified adaptor protein complex 1 sigma 3 subunit (AP1S3) as a dependency factor for the efficient HCV infection in hepatoma cells. AP1S3 silencing in cultivated Huh7.5.1 cells significantly reduced the production of HCV progeny particles. Immunoprecipitation analysis revealed that AP1S3 interacted with the HCV E2 protein. With this interaction, AP1S3 could protect HCV E2 from ubiquitin-mediated proteasomal degradation. Using in vivo ubiquitylation assay, we identified that E6-Associated Protein (E6AP) was associated with HCV E2. In addition, treatment with synthetic peptide that contains the AP1S3-recognized motif inhibited HCV infection in Huh7.5.1 cells. Our data reveal AP1 as a novel host network that is required by viruses during infection and provides a potential target for developing broad-spectrum anti-virus strategies. PMID:27079945

  7. [The press and family planning].

    PubMed

    Abraham De D'ornellas, R

    1987-01-01

    The treatment in the press of family planning hinges on two fundamental factors: the taboo of the leftist groups and the taboo of the Catholic Church, whose head is against abortion under any circumstances. Leftist views insinuate that family planning is the genocidal plan of North American imperialists against the Third World and, in particular, against Latin America. This genocidal plan is supposed to subject poor populations to international schemes. In the press family planning is often treated in a sanctimonious fashion, lumping it together with topics like pornography, sex, and violence. In 1983 the daily newspaper Expreso published a supplement running every week for almost three months about the issue of population, which dealt fairly extensively with such topics as population and housing, education, employment, and urban proliferation, as well as responsible parenthood and child survival. In addition, there was a detailed description of contraceptive methods. In October 1986 another surprising thing happened: the President of Peru talked about the topic of family planning, which at the time was an act of courage. Since then much has changed; the whole world is interested in family planning and certain aspects of population. Since October 1986 more has been published in this domain than during the preceding 20 years. In contrast, the Church reacted differently to this issue: after some initial caution, the conference of Peruvian bishops attacked all methods of modern contraceptives and private institutions of family planning. The information boom in family planning will certainly continue. At the moment this flood of articles and editorials about the issue is an expression of the anxiety of families related to uncontrolled reproduction and the fear of overpopulation in large cities devoid of minimal services. PMID:12281466

  8. Combustion Response of AP Composite Propellants

    NASA Technical Reports Server (NTRS)

    Shusser, Michael; Cohen, Norman S.; Culick, E. C.

    2000-01-01

    The Cohen & Strand model for AP composite propellants is applied as boundary conditions, one for AP and one for binder, in solving the heat conduction equation in each to compute linear and non-linear combustion response properties for each and for the aggregate propellant. Iterations couple AP and binder through the quasi-steady flame processes. Illustrative results for linear response functions (pressure-coupled and velocity-coupled) are presented for a monomodal AP propellant varying AP size, pressure and crossflow speed, and examples of non-linear responses to arbitrary waveforms are shown. A quantitative comparison with response function data is limited to one well-characterized research formulation. Mechanistic implications are discussed, including recommendations for future modeling work.

  9. APS undulator radiation: First results

    SciTech Connect

    Cai, Z.; Dejus, R.J.; Hartog, P.D.

    1995-12-31

    The first undulator radiation has been extracted from the Advanced Photon Source (APS). The results from the characterization of this radiation are very satisfactory. With the undulator set at a gap of 15.8 mm (K=1.61), harmonics as high as the 17th were observed using a crystal spectrometer. The angular distribution of the third-harmonic radiation was measured, and the source was imaged using a zone plate to determine the particle beam emittance. The horizontal beam emittance was found to be 6.9 {plus_minus} 1.0 nm-rad, and the vertical emittance coupling was found to be less than 3%. The absolute spectral flux was measured over a wide range of photon energies, and it agrees remarkably well with the theoretical calculations based on the measured undulator magnetic field profile and the measured beam emittance. These results indicate that both the emittance of the electron beam and the undulator magnetic field quality exceed the original specifications.

  10. The Press vs. Professional Wrestling: How the Press Covered WrestleMania III.

    ERIC Educational Resources Information Center

    Ortizano, Giacomo L.

    This paper analyzes the relationship between the press and professional wrestling. It examines professional wrestling as a business and the conflicting goals of the promoters and the press. The paper focuses on how the press covered the most widely viewed professional wrestling show of all time, WrestleMania III (looking at newspaper coverage…

  11. Teenagers as Victims in the Press

    ERIC Educational Resources Information Center

    Andersson, Gunvor; Lundstrom, Tommy

    2007-01-01

    Research into press reporting on young people has tended to concentrate on young people as offenders. In contrast, this article focuses on press coverage of teenagers as victims. Reports in two Swedish newspapers (a morning broadsheet and an evening tabloid) were studied over a period of four months and subjected to a qualitative analysis of…

  12. Special Section: University Presses and Libraries.

    ERIC Educational Resources Information Center

    Berry, John; And Others

    1986-01-01

    Describes issues discussed at the Association of American University Presses, June 1986 meeting, as being divided between those interested in using the techniques of commercial publishers and those committed to publishing what is worthy. Chandler Grannis describes "New Directions for University Presses" and Doug Armato "The Power of 'Serious'…

  13. The Lily-White University Presses.

    ERIC Educational Resources Information Center

    Shin, Annys

    1996-01-01

    Argues that the university presses are immune from racial change and discusses the problem of using location as an argument for not being able to lure blacks into university publishing. Howard University Press is used to illustrate the problem of budget cutting and the ability to boost black recruitment efforts or establish a united black press…

  14. The Mythology of the Penny Press.

    ERIC Educational Resources Information Center

    Nerone, John C.

    1987-01-01

    Examines common scholarly characterizations of the American penny press of the 1830s and 40s that together provide a myth of origins of the contemporary U.S. press. Criticizes inaccuracies and misleading elements in this mythology and its implications for subsequent debate about U.S. journalism. (JK)

  15. The Egyptian Press: An Official Fourth Estate.

    ERIC Educational Resources Information Center

    Lawhorne, Clifton O.

    A descriptive study based on Egyptian law, printed sources, and interviews clarifies our picture of the Egyptian Press by examining its status as a constitutionally mandated "Fourth Estate." The constitutional amendment, the resultant Egyptian Press Law, and the "Law Of Shame" (all passed in 1980), are designed to create a heavily controlled press…

  16. Freedom of the Press vs. Public Access.

    ERIC Educational Resources Information Center

    Schmidt, Benno C., Jr.

    This book surveys the implications of freedom of the press for a constitutionally rooted public right of access to electronic and print media. Part one provides general perspectives on access to the media, including discussions of access in relation to the Supreme Court, to First Amendment history and theory, to current perceptions of the press,…

  17. Fracture toughness of hot-pressed beryllium

    NASA Technical Reports Server (NTRS)

    Lemon, D. D.; Brown, W. F., Jr.

    1985-01-01

    This paper presents the results of an investigation into the fracture toughness, sustained-load flaw growth, and fatigue-crack propagation resistance of S200E hot-pressed beryllium at room temperature. It also reviews the literature pertaining to the influence of various factors on the fracture toughness of hot-pressed beryllium determined using fatigue-cracked specimens.

  18. The Pedagogical Press: Problems and Trends.

    ERIC Educational Resources Information Center

    Soviet Education, 1990

    1990-01-01

    Presents a discussion by journalists, scientists, and writers on educational problems in the Soviet Union. Focuses on the the role of the pedagogical press in restructuring public education in light of perestroika. Calls for press involvement in defining and developing public education. Lists questions for consideration and invites responses. (NL)

  19. Development of the AP Technology Through Time

    NASA Astrophysics Data System (ADS)

    Charmier, F.; Martin, O.; Gariepy, R.

    2015-02-01

    This article presents the historical development of the AP Technology (Aluval, Voreppe, France) pot series starting with the AP13 in the 1960s, followed by the AP18 and the AP30 in the 1980s and 1990s. For most of the modern-era technology, from the late 1970s on, development has been based on a three-stage pattern, the first one being the pot modeling, followed by the pot prototype stage, and then the industrial stage, which fully validated the technology. This development pattern has proven to be successful since it has led to the very robust AP Technology pot design generation and a large number of greenfield smelters built in the 1990-2010 selected the AP Technology design. AP60 is the latest of this series: The development at the prototype level was initiated in the 1990s and is presented in the article. It is now followed by the first industrial realization at Jonquière with the startup in late 2013 and the full validation of the technology in mid-2014. The development of APXe, which aims at very low energy consumption, uses many common elements pertaining to the AP60 design and is presented in the article. AP Technology has also addressed the need for continuous and fast improvement of pot performances adapted to each existing client or site specifics; for this purpose, a new development methodology has recently emerged thanks to the very high modeling capabilities. This methodology, based on the validation of "technology bricks" and their integration in the final design following a strict process, is presented in the last section of this article.

  20. AP Trends: Tests Soar, Scores Slip--Gaps between Groups Spur Equity Concerns

    ERIC Educational Resources Information Center

    Cech, Scott J.

    2008-01-01

    More students are taking Advanced Placement tests, but the proportion of tests receiving what is deemed a passing score has dipped, and the mean score is down for the fourth year in a row. Data released here this week by the New York City-based nonprofit organization that owns the AP brand shows that a greater-than-ever proportion of students…

  1. Number of Schools Offering AP Falls after First Audit of Courses

    ERIC Educational Resources Information Center

    Cech, Scott J.

    2007-01-01

    This article reports the findings of the first audit of Advanced Placement (AP) courses. One of the more striking effects of the audit, the results of which were released recently by the College Board, was a steep drop in the number of schools offering Advanced Placement courses. After more than 30 years of steady growth, the number of schools…

  2. The Reluctant Reformation: On Criticizing the Press in America.

    ERIC Educational Resources Information Center

    Brown , Lee

    This book examines the status of the press and the criticism surrounding it. Chapter 1 attempts to relate theories of criticism to the contemporary press, to define the public interest relative to the press, and to discuss the role of criticism and the social responsibility of the press. Chapter 2 presents a brief history of press criticism from…

  3. Stop the Presses! Getting the Local Paper to Work for You.

    ERIC Educational Resources Information Center

    Wales, Andrew

    2001-01-01

    Discusses four different ways art teachers can take advantage of the local newspapers in their area: (1) write press releases; (2) ask a reporter to cover school "art news"; (3) take advantage of "Newspapers in Education" programs; and (4) submit student artwork to contests. (CMK)

  4. Mariner Mars 1971: Press kit

    NASA Technical Reports Server (NTRS)

    Mittauer, R. T.

    1971-01-01

    The news release describes the 1971 launches of Mariner 8 and 9 which were to be the first attempt by NASA to orbit another planet, Mars. Described are: (1) mission capsule; (2) planetary missions; (3) aiming zones; (4) the spacecraft; (5) scientific experiments to be performed; (6) Atlas Centaur launch vehicle; (7) launch operations; (8) tracking and data system and mission operations; and (9) Mariner Mars 71 team and subcontractors.

  5. APS Activities with Other Professional Societies

    NASA Astrophysics Data System (ADS)

    Slakey, Francis

    2006-03-01

    In 1981, the APS Council issued a statement that opposed ``equal time'' presentation in public school science classes of creationism and evolution. The statement clarified that ``Scientific inquiry and religious beliefs are two distinct elements of the human experience. Attempts to present them in the same context can only lead to misunderstandings of both.'' The APS Council revisited the issue in 1999 when a school board in Kansas attempted to eliminate the Big Bang, among other issues, from the science curriculum. Since that time, the APS has been more directly involved in confronting efforts that would dilute the teaching of science in public school science classes. This talk will review the APS activities and describe a developing multi-science society activity.

  6. Mechanical Properties from PBX 9501 Pressing Study

    NASA Astrophysics Data System (ADS)

    Graff Thompson, Darla; Wright, Walter J.

    2004-07-01

    A PBX 9501 pressing study was conducted by researchers in ESA-WMM, LANL, to identify the hydrostatic pressing parameters most important in fabricating high-density parts with uniform density. In this study, 31 charges were pressed using a full permutation of six pressing parameters. Five charges from the set of 31 were selected for an evaluation of their mechanical properties, specifically uniaxial compression and tension. Charges were selected to 1) span the density range of the study, and 2) allow two direct comparisons of pressing parameters independent of bulk density (density has a well-established affect on some material properties). Three PBX 9501 charges pressed isostatically at Pantex Plant in Amarillo, TX were also included in the study. The tensile properties of the 8 charges varied significantly. Careful evaluation of the results suggests that an increase in pressing temperature may correlate with an increase in tensile stress (strength) and a decrease in strain (ductility). Trends in compression exist but are less pronounced. In an effort to explore the relationship between pressing temperature and tensile strength, four sheets of Estane polymer (a component of the PBX 9501 binder) were compression molded at 70, 90, 110 and 130°C. The tensile strength of Estane was observed to increase by a factor of nearly 20 when the molding temperature was increased from 70 to 90°C (strength increase was negligible beyond 90°C). We present an outline of ongoing work that will irrefutably quantify the mechanical property affects of both pressing temperature and dwell time on PBX 9501.(LA-UR 03-4842).

  7. (Very) Slow Rotation of Magnetic Ap Stars

    NASA Astrophysics Data System (ADS)

    Mathys, G.

    2015-04-01

    To this date, 33 magnetic Ap stars that have periods of variation longer than 30 days are known. They represent a considerable fraction of the total number of Ap stars whose period has been reliably determined. All the available evidence unambiguously indicates that the observed variations of those long-period Ap stars result from the changing aspect of their visible hemisphere as they rotate, thus that the oblique rotator model is applicable throughout the whole range of periods of variation of the Ap stars. We show that the periods of the most slowly rotating Ap stars must be of the order of 300 years, and that some may even be longer, possibly up to 1000 years. The 5 to 6 orders of magnitude spanned by the rotation periods of the Ap stars present a major challenge for the understanding of their origin and their evolution. To guide the theoretical developments, observational hints may be found in possible differences between the magnetic properties of stars that have rotation periods in different ranges. Such differences are starting to emerge from the existing data. To increase their significance level, study of the longest-period stars must be continued over their full rotation cycle. Failure to secure observations now may leave critical data missing for several decades, or even centuries.

  8. STS-8 onboard crew press conference

    NASA Technical Reports Server (NTRS)

    1983-01-01

    Six news reporters listen to a response from Astronaut Guion S. Bluford (note TV monitor) in a rare space-to-Earth press conference involving all the STS-8 crew. The participants are, left to right, Gary Schwitzer, Cable News Network; Morton Dean, CBS; Roy Neal, NBC; Lynn Sherr, ABC; Howard Benedict, Associated Press; Al Rossiter, United Press International. The astronauts on the monitor are Richard H. Truly, cneter left, crew commander; Daniel C. Brandenstein, lower left, pilot; and Dr. William E. Thornton, upper left, Guion S. Bluford, upper right; and Dale E. Gardner, all mission specialists.

  9. Powder pressing in a macrosonic field

    NASA Technical Reports Server (NTRS)

    Protipopescu, A.; Dragan, O.; Ciovica, D.

    1974-01-01

    An investigation was conducted to extend the technology of powder product manufacturing to new forms and sizes, to improve their quality as well as pressing efficiency and to reduce waste. In the course of metal and nonmetal powder briquette pressing, macrosounds were associated with the external static pressing force, which led to an increase in the relative height, density and physicomechanical characteristics of the briquettes. This method permits the extension of the range of products that can be manufactured from powders and the improvement of their quality.

  10. Course Does a Critical Study of Press in Capitalist Society.

    ERIC Educational Resources Information Center

    Winter, James

    1986-01-01

    Describes a course that documents in often laborious and relatively uncritical detail the history of the Canadian press and its American and British antecedents. Describes a course on the contemporary press consisting of various forms of press criticism. (HTH)

  11. Regulation of atriopeptin release from the isolated rat heart

    SciTech Connect

    Currie, M.G.; Newman, W.H.

    1986-03-05

    Recent studies have demonstrated that the mammalian atria possess an endocrine function which appears to play a role in the regulation of systemic arterial pressure, fluid balance, and electrolyte homeostasis. They have begun to study the regulation of atriopeptin (atrial natriuretic factor) release into the coronary effluent of the isolated perfused rat heart. Characterization by high pressure liquid chromatography of the form of the hormone released indicates that the predominant form is the active low MW circulating hormone not the pro-hormone. The release of immunoreactive atriopeptin (iAP) was stimulated by infusion of norepinephrine (1 ..mu..M) or epinephrine (1 ..mu..M) 3.0 and 2.6-fold, respectively. The ..beta..-adrenergic agonist isoproterenol and the ..cap alpha..-2 adrenergic agonist BHT-920 lacked effects on iAP release. On the other hand, the ..cap alpha..-1 adrenergic agonist phenylephrine caused a dose-dependent increase in release of iAP. Release of iAP stimulated by phenylephrine was inhibited by the ..cap alpha.. antagonist phentolamine. Further, iAP release was stimulated 4.2-fold by phorbol ester (1 ..mu..M) but was not affected by 4-..beta.. phorbol (1 ..mu..M). From these collective data they conclude that the release of atriopeptin is stimulated by ..cap alpha..-1 receptor activation and that protein kinase C participates in the regulation of secretion. The data suggests that the sympathetic nervous system may play a physiologic role in the regulation of atriopeptin secretion.

  12. Comprehensive management of hot-press hand injuries: long-term outcomes following reconstruction and rehabilitation.

    PubMed

    Hultman, Charles Scott; Erfanian, Kamil; Fraser, James; Thornton, Sydney J; Calvert, Catherine S; Cairns, Bruce A

    2010-05-01

    Hot-press hand injuries create significant challenges, in terms of acute coverage and restoration of function, and long-term outcomes are largely unknown. This article reviews the comprehensive management of hot-press hand injuries--which includes damage control procedures, resurfacing, reconstruction, and rehabilitation--and assesses outcomes such as return to work and final impairment ratings. We treated 56 patients with hot-press hand injuries, at a verified, accredited burn center in the Southeast between 1994 and 2008. Mechanism included laundry press (42 cases), industrial press (11 cases), and home appliance (3 cases). Mean burn size was 118 cm2, with 43 full-thickness and 13 partial thickness injuries. Mean follow-up was 17.7 months. During this 15-year period, 39 patients (70%) were admitted acutely (mean length of stay: 10.4 days), 48 patients (86%) required operative intervention, and 28 patients (50%) had secondary reconstruction, which included nerve decompression (11 cases), contracture release (11 cases), tendon procedures (11 cases), and joint repair (5 cases). Mean final impairment rating was 22%, with 38 patients (68%) returning to work. Hot-press hand burns can be devastating, but return to work is possible for most patients. We recommend early wound excision, aggressive perioperative hand therapy, low threshold for reconstructive procedures, and rehabilitative support. PMID:20395811

  13. Apollo 13 Facts [Post Flight Press Conference

    NASA Technical Reports Server (NTRS)

    2001-01-01

    The Apollo 13 astronauts, James Lovell, Jr., John Swigert, Jr., and Fred Haise, Jr., are seen during this post flight press conference. They describe their mission and answer questions from the audience.

  14. Student Press Law: What Lies Ahead?

    ERIC Educational Resources Information Center

    Eveslage, Thomas

    1980-01-01

    Assesses recent developments in student press rights in the areas of prior restraint, libel and obscenity, and material and substantial disruption, and predicts future trends in student rights litigation. (TJ)

  15. Gas-driven filter pressing in magmas

    USGS Publications Warehouse

    Sisson, T.W.; Bacon, C.R.

    1999-01-01

    Most silicic and some mafic magmas expand via second boiling if they crystallize at depths of about 10 km or less. The buildup of gas pressure due to second boiling can be relieved by expulsion of melt out of the region of crystallization, and this process of gas-driven filter pressing assists the crystallization differentiation of magmas. For gas-driven filter pressing to be effective, the region of crystallization must inflate slowly relative to buildup of pressure and expulsion of melt These conditions are satisfied in undercooled magmatic inclusions and in thin sheets of primitive magma underplating cooler magma reservoirs. Gas-driven filter pressing thereby adds fractionated melt to magma bodies. Gas-driven filter pressing is probably the dominant process by which highly evolved melts segregate from crystal mush to form aplitic dikes in granitic plutons; this process could also account for the production of voluminous, crystal-poor rhyolites.

  16. Thermal Conductances of Pressed Copper Contacts

    NASA Technical Reports Server (NTRS)

    Salerno, L.; Kittel, P.; Spivak, A.

    1986-01-01

    Report describes investigation of thermal conductivities of smooth copper contacts pressed together at liquid-helium temperatures. Investigation prompted by need for accurate thermal models for infrared detectors and other cryogenic instruments.

  17. Simplified SBLOCA Analysis of AP1000

    SciTech Connect

    Brown, William L.

    2004-07-01

    The AP1000 is a 1000 MWe advanced nuclear power plant design that uses passive safety features such as a multi-stage, automatic depressurization system (ADS) and gravity-driven, safety injection from core make-up tanks (CMTs) and an in-containment refueling water storage tank (IRWST) to mitigate SBLOCA events. The period of most safety significance for AP1000 during a SBLOCA event is typically associated with the actuation of the fourth stage of the ADS and subsequent transition from CMT to IRWST safety injection. As this period of a SBLOCA is generally of a quasi-steady nature, the integral performance of the AP1000 can be understood and evaluated with a simplified model of the reactor vessel, ADS, and safety injection from the CMTs and IRWST. The simplified model of the AP1000 consists of a series of steady state simulations that uses drift flux in the core region and homogeneous treatment of the core exit region including the ADS flow paths to generate a family of core flow demand curves as a function of system pressure (i.e. mass flow required to satisfy core cooling). These core flow demand curves are plotted against passive safety system supply curves from the CMTs and IRWST to demonstrate the adequacy of the integral performance of the AP1000 during the most important phase of a SBLOCA. (author)

  18. Tank 241-AP-107, grab samples 7AP-97-1, 7AP-97-2 and 7AP-97-3 analytical results for the final report

    SciTech Connect

    Steen, F.H.

    1997-12-22

    This document is the final report for tank 241-AP-107 grab samples. Three grab samples were collected from riser 1 on September 11, 1997. Analyses were performed on samples 7AP-97-1, 7AP-97-2 and 7AP-97-3 in accordance with the Compatibility Grab Sampling and Analysis Plan (TSAP) (Sasaki, 1997) and the Data Quality Objectives for Tank Farms Waste Compatibility Program (DQO) (Rev. 1: Fowler, 1995; Rev. 2: Mulkey and Nuier, 1997). The analytical results are presented in the data summary report (Table 1). A notification was made to East Tank Farms Operations concerning low hydroxide in the tank and a hydroxide (caustic) demand analysis was requested. The request for sample analysis (RSA) (Attachment 2) received for AP-107 indicated that the samples were polychlorinated biphenyl (PCB) suspects. Therefore, prior to performing the requested analyses, aliquots were made to perform PCB analysis in accordance with the 222-S Laboratory administrative procedure, LAP-101-100. The results of this analysis indicated that no PCBs were present at 50 ppm and analysis proceeded as non-PCB samples. The results and raw data for the PCB analysis will be included in a revision to this document. The sample breakdown diagrams (Attachment 1) are provided as a cross-reference for relating the tank farm customer identification numbers with the 222-S Laboratory sample numbers and the portion of sample analyzed.

  19. Automated Plasma Spray (APS) process feasibility study

    NASA Technical Reports Server (NTRS)

    Fetheroff, C. W.; Derkacs, T.; Matay, I. M.

    1981-01-01

    An automated plasma spray (APS) process was developed to apply two layer (NiCrAlY and ZrO2-12Y2O3) thermal barrier coatings to aircraft and stationary gas turbine engine blade airfoils. The APS process hardware consists of four subsystems: a mechanical positioning subsystem incorporating two interlaced six degree of freedom assemblies (one for coating deposition and one for coating thickness monitoring); a noncoherent optical metrology subsystem (for in process gaging of the coating thickness buildup at specified points on the specimen); a microprocessor based adaptive system controller (to achieve the desired overall thickness profile on the specimen); and commerical plasma spray equipment. Over fifty JT9D first stage aircraft turbine blade specimens, ten W501B utility turbine blade specimens and dozens of cylindrical specimens were coated with the APS process in preliminary checkout and evaluation studies. The best of the preliminary turbine blade specimens achieved an overall coating thickness uniformity of 53 micrometers (2.1 mils), much better than is achievable manually. Comparative evaluations of coating thickness uniformity for manually sprayed and APS coated specimens were performed. One of the preliminary turbine blade evaluation specimens was subjected to a torch test and metallographic evaluation. Some cylindrical specimens coated with the APS process survived up to 2000 cycles in subsequent burner rig testing.

  20. Building an AP Social Studies Program with Non-Traditional AP Students

    ERIC Educational Resources Information Center

    Ashmead, Amanda; Blanchette, Sue

    2013-01-01

    Equal access to education, that is to a high quality education, has increasingly come to mean access to an Advanced Placement program. In recent years, there has been steady attention paid to opening access to AP programs. The 9th annual College Board report (2013) stated "students who succeed on an AP Exam during high school typically…

  1. Laa1p, a Conserved AP-1 Accessory Protein Important for AP-1 Localization in Yeast

    PubMed Central

    Fernández, G. Esteban

    2006-01-01

    AP-1 and Gga adaptors participate in clathrin-mediated protein transport between the trans-Golgi network and endosomes. Both adaptors contain homologous domains that act to recruit accessory proteins involved in clathrin-coated vesicle formation, but the spectrum of known adaptor-binding partners is limited. This study describes an evolutionarily conserved protein of Saccharomyces cerevisiae, Laa1p (Yjl207cp), that interacts and functions specifically with AP-1. Deletion of LAA1, when combined with a conditional mutation in clathrin heavy chain or deletion of GGA genes, accentuated growth defects and increased disruption of clathrin-dependent α-factor maturation and transport of carboxypeptidase Y to the vacuole. In contrast, such genetic interactions were not observed between deletions of LAA1 and AP-1 subunit genes. Laa1p preferentially interacted with AP-1 compared with Gga proteins by glutathione S-transferase-fusion affinity binding and coimmunoprecipitations. Localization of AP-1 and Laa1p, but not Gga proteins, was highly sensitive to brefeldin A, an inhibitor of ADP-ribosylation factor (Arf) activation. Importantly, deletion of LAA1 caused mislocalization of AP-1, especially in cells at high density (postdiauxic shift), but it did not affect Gga protein distribution. Our results identify Laa1p as a new determinant of AP-1 localization, suggesting a model in which Laa1p and Arf cooperate to direct stable association of AP-1 with appropriate intracellular membranes. PMID:16687571

  2. Ectopic expression of FaesAP3, a Fagopyrum esculentum (Polygonaceae) AP3 orthologous gene rescues stamen development in an Arabidopsis ap3 mutant.

    PubMed

    Fang, Zheng-wu; Qi, Rui; Li, Xiao-fang; Liu, Zhi-xiong

    2014-10-25

    Arabidopsis thaliana APETALA3 (AP3) and Antirrhinum majus DEFICIENS (DEF) MADS box genes are required to specify petal and stamen identity. AP3 and DEF are members of the euAP3 lineage, which arose by gene duplication coincident with radiation of the core eudicots. In order to investigate the molecular mechanisms underlying organ development in early diverging clades of core eudicots, we isolated and identified an AP3 homolog, FaesAP3, from Fagopyrum esculentum (buckwheat, Polygonaceae), a multi-food-use pseudocereal with healing benefits. Protein sequence alignment and phylogenetic analyses revealed that FaesAP3 grouped into the euAP3 lineage. Expression analysis showed that FaesAP3 was transcribed only in developing stamens, and differed from AP3 and DEF, which expressed in developing petals and stamens. Moreover, ectopic expression of FaesAP3 rescued stamen development without complementation of petal development in an Arabidopsis ap3 mutant. Our results suggest that FaesAP3 is involved in the development of stamens in buckwheat. These results also suggest that FaesAP3 holds some potential for biotechnical engineering to create a male sterile line of F. esculentum. PMID:25149019

  3. Plyler Prize and APS Fellow Introductions

    NASA Astrophysics Data System (ADS)

    Nathanson, Gilbert

    2014-03-01

    The Division of Chemical Physics is delighted to announce the 2013 APS Fellows sponsored by DCP and to honor the 2014 Earl K. Plyler Prize Award winner. The new APS Fellows are: Ilan Benjamin, Hua Guo, Manos Mavrikakis, Josef Paldus, Joern Siepmann, Hans-Peter Steinrueck, Douglas Tobias, Angela Wilson, and Yijing Yan. The citations for each awardee will be read out loud. I will also introduce Prof. Lai-Sheng Wang of the Department of Chemistry at Brown University, who was awarded the 2014 Plyler Prize for Molecular Spectroscopy and Dynamics. Please come learn about these extraordinary scientists during this prize session. Prof. Wang's Plyler Prize talk will follow immediately after this introduction. For more information, see http://www.aps.org/units/dcp/.

  4. On the periodic variations of geomagnetic activity indices Ap and ap

    NASA Astrophysics Data System (ADS)

    Schreiber, H.

    1998-05-01

    Yearly averages of geomagnetic activity indices Ap for the years 1967-1984 are compared to the respective averages of 2·Bs, where v is the solar wind velocity and Bs is the southward interplanetary magnetic field (IMF) component. The correlation of both quantities is known to be rather good. Comparing the averages of Ap with 2 and Bs separately we find that, during the declining phase of the solar cycle, 2 and during the ascending phase Bs have more influence on Ap. According to this observation (using Fourier spectral analysis) the semiannual and 27 days, Ap variations for the years 1932-1993 were analysed separately for years before and after sunspot minima. Only those time-intervals before sunspot minima with a significant 27-day recurrent period of the IMF sector structure and those intervals after sunspot minima with a significant 28-28.5-day recurrent period of the sector structure were used. The averaged spectra of the two Ap data sets clearly show a period of 27 days before and a period of 28-29 days after sunspot minimum. Moreover, the phase of the average semiannual wave of Ap is significantly different for the two groups of data: the Ap variation maximizes near the equinoxes during the declining phase of the sunspot cycle and near the beginning of April and October during the ascending phase of the sunspot cycle, as predicted by the Russell-McPherron (R-M) mechanism. Analysing the daily variation of ap in an analogue manner, the same equinoctial and R-M mechanisms are seen, suggesting that during phases of the solar cycle, when ap depends more on the IMF-Bs component, the R-M mechanism is predominant, whereas during phases when ap increases as v increases the equinoctial mechanism is more likely to be effective.

  5. ap-9-(meta-tert-butylphenyl)fluorene.

    PubMed

    Robinson, Paul D; McLean, Aaron W; Meyers, Cal Y

    2003-10-01

    The title compound, C(23)H(22), (I), crystallizes in an ap conformationThe designations sp (synperiplanar) and ap (antiperiplanar) for these fluorene rotamers are in accordance with Rule E-6.6, IUPAC Tentative Rules, Section E, Fundamental Stereochemistry [J. Org. Chem. (1970), 35, 2861]. and its melt readily recrystallizes on cooling, in contrast to the corresponding 9-fluorenol compound, (II), which is sp and which melts without decomposition and fails to recrystallize over a long period. Both of these differences are ascribed to the intermolecular hydrogen bonding in (II), which is absent in (I) and which leads to distinctly different molecular packing in the two compounds. PMID:14532663

  6. EPICS release 3.11 specific documentation -- EPICS release notes for 3.11

    SciTech Connect

    1994-01-19

    EPICS release 3.11 is now ready for user testing. A person who wants to set up a simplified application environment to boot an IOC and create databases using R3.11 should follow the directions in Appendix B, page 27, of the EPICS Source/Release Control Manual, Sept. 20, 1993. The R3.11 EPICS path at ANL/APS is /net/phebos/epics/R3.11 so the command to get the new release is /net/phebos/epics/R3.11/Unix/share/bin/getrel /net/phebos/epics/R3.11. An existing R3.8 short form report can be copied to this new directory and used to create a database. ANL/APS is currently testing an Application Developers Source/Release control system. It is not yet ready for general distribution. Attached are the EPICS R3.11 release notes.

  7. Influence of Volume Deformation Rate on the Intensity of Oil-Bearing Crop Pressing-out in Relation to Rape Extrudate

    NASA Astrophysics Data System (ADS)

    Slavnov, E. V.; Petrov, I. A.

    2015-07-01

    The influence of the volume deformation rate on the intensity of piston pressing-out of oil has been investigated. The results of pressing by a piston moving with different speeds are presented. Mathematical simulation is carried out for the stage of pressing-out after the termination of sample loading, when oil release occurs due to the accumulated deformations of the skeleton. It has been assumed that in mechanical pressing there remains the least residual content of oil. A dimensionless complex representing the ratio of the characteristic times of loading to the material response (the process of pressing) has been obtained. The dependence of the rate of oil pressing-out at the stage of pressure relaxation on the dimensionless complex has been determined.

  8. Graphic Arts: Book Three. The Press and Related Processes.

    ERIC Educational Resources Information Center

    Farajollahi, Karim; And Others

    The third of a three-volume set of instructional materials for a graphic arts course, this manual consists of nine instructional units dealing with presses and related processes. Covered in the units are basic press fundamentals, offset press systems, offset press operating procedures, offset inks and dampening chemistry, preventive maintenance…

  9. Along Freedom's Double Edge: The Arab Press Under Israeli Occupation.

    ERIC Educational Resources Information Center

    Nasser, Munir K.

    This paper examines the Arab press under Israeli occupation and presents two hypotheses: freedom of the press under occupation serves both Israeli interests and the Arab population, and freedom of the Arab press under occupation is "relative" and "controlled." By allowing freedom of expression, the Israelis achieve several aims: a free press will…

  10. Textbook Sales Drop, and University Presses Search for Reasons

    ERIC Educational Resources Information Center

    Howard, Jennifer

    2008-01-01

    This article reports that textbook sales are falling at many university presses, a trend that has accelerated in the past couple of months. That's the word from press directors anxious about the decline but unsure what's causing it or how to stop it. Not every press has been affected. Two of the biggest players, Oxford University Press and…

  11. Roller presses -- Versatile equipment for mineral processing

    SciTech Connect

    Pietsch, W.

    1995-12-31

    Roller presses were first invented in the middle of the 19th century for the economical size enlargement of coal fines as fuels. In addition to contemporary coal briquetting, in fields such as smokeless fuel and form-coke, it was found that redesigned and modernized roller presses, which are now capable of exerting high forces, are versatile machines for many tasks in mineral processing. Today they are used for: the classic pressure agglomeration and the new high pressure comminution. In pressure agglomeration, the characteristics of fine minerals are improved by forming briquettes or granulated products from compacts. During size enlargement with roller presses briquettes are directly obtained while granular materials are produced by crushing and sizing of compacted sheets. A relatively new application of roller presses in mineral processing is the utilization of the crushing effect when brittle materials pass the nip area between the rollers. It was found that this crushing mechanism is very efficient thus saving energy, particularly in grinding circuits handling large capacities. The paper introduces the fundamentals of the process and describes the design as well as applications of modern roller presses in mineral processing.

  12. Lever-press conditioning in the crab.

    PubMed

    Abramson, C I; Feinman, R D

    1990-08-01

    An operant chamber has been developed for studying lever-press conditioning in the green crab Carcinus maenas. In one series of experiments, animals were presented with a single bar and were reinforced with food for every bar press. Performance increased over time and high rates of responding were observed after 2 days of training. The response rate was always higher than that for a yoked (noncontingent) control group. When the contingencies were switched, the animals adjusted to the new conditions. Discrimination in the lever-press apparatus was demonstrated in a second experiment in which crabs had to choose between two bars, one (S+) caused food to be dispensed while the other (S-) was inactive. Experimental animals pressed the S+ bar at a significantly higher rate than the S- bar. When the contingencies associated with the lever were reversed, animals learned to switch to the correct bar by the second day. It was not necessary to reinforce every response: animals maintained high rates of responding on a schedule where every other response was reinforced. Animals used different methods of pressing the bar; the most common was extension of the claw, predominantly at the meropodite-carpopodite joint. PMID:2255730

  13. AUPress: A Comparison of an Open Access University Press with Traditional Presses

    ERIC Educational Resources Information Center

    McGreal, Rory; Chen, Nian-Shing

    2011-01-01

    This study is a comparison of AUPress with three other traditional (non-open access) Canadian university presses. The analysis is based on the rankings that are correlated with book sales on Amazon.com and Amazon.ca. Statistical methods include the sampling of the sales ranking of randomly selected books from each press. The results of one-way…

  14. A precision press-fit instrument for assembling small parts

    NASA Astrophysics Data System (ADS)

    Lou, Zhifeng; Wang, Xiaodong; You, Bo; Xu, Yang

    2015-02-01

    In the paper, a precision press-fit instrument for assembling small interference fitting parts is introduced, which includes pressing module and parts alignment module. The pressing module was used to clamp and position parts, and parts alignment module was used for the two parts' alignment. Through analyzing press-fit control method, component alignment and adjustment strategy, and machine vision device calibration method, the instrument meets the pressing requirements of precision small components. Finite element method is used to predict the reasonable range of press-fit force, and pressing result of the instrument is tested by experiments.

  15. Effect of uniaxially pressing ordinary Portland cement pastes containing metal hydroxides on porosity, density, and leaching

    SciTech Connect

    Cheeseman, C.R.; Asavapisit, S.; Knight, J.

    1998-11-01

    Synthetic metal hydroxide wastes containing Zn and Pb have been mixed with partially hydrated cement and uniaxially pressed. The effect on porosity, pore size distribution, and bulk and skeletal densities has been characterized using mercury intrusion porosimetry. Ca(OH){sub 2} formation has been determined using differential thermal analysis and metal leaching has been assessed in a series of static leach tests completed on monolithic samples. Pressed solidified materials have increased density, reduced porosity, and reduced Ca(OH){sub 2}. They exhibit increased resistance to acid attack in terms of sample weight loss during leaching due to reduced release of alkalis. Leaching of Zn and Pb is primarily determined by pH. A peak observed in Zn leaching from pressed samples is due to the effect of changing leachate pH on the dominant Zn species present.

  16. The Dao of human cloning: utopian/dystopian hype in the British press and popular films.

    PubMed

    Jensen, Eric

    2008-04-01

    The issue of human cloning has featured in the national science policy agendas in both the United States and the United Kingdom since the announcement in 1997 of Dolly the cloned sheep's birth in Scotland. Such news stories suggesting the imminent cloning of humans have inspired fictional entertainment media over the years, including numerous popular films. Study 1 examines elite British press coverage of human cloning from 1997 to 2004 (n = 857). Study 2 focuses on five human cloning films released between 1978 and 2003. Two sharply divergent discourses emerged from these data. Unqualified hope and habitually hyped claims of future cures permeated the press discourse. In contrast, the films constructed human cloning as an inherently dangerous technology often wielded by hubristic scientists in the tradition of Frankenstein. Both the predominately positive hype in the broadsheet press and the largely negative hype in the films indicate an impoverished and "thin" public debate on the issue of human cloning. PMID:19391375

  17. Implementing Strategies for Drying and Pressing Wood Without Emissions Controls

    SciTech Connect

    Sujit Banerjee; Terrance Conners

    2007-09-07

    Drying and pressing wood for the manufacture of lumber, particleboard, oriented strand board (OSB), veneer and medium density fiberboard (MDF) release volatile organic compounds (VOCs) into the atmosphere. These emissions require control equipment that are capital-intensive and consume significant quantities of natural gas and electricity. The objective of our work was to understand the mechanisms through which volatile organic compounds are generated and released and to develop simple control strategies. Of the several strategies developed, two have been implemented for OSB manufacture over the course of this study. First, it was found that increasing final wood moisture by about 2-4 percentage points reduced the dryer emissions of hazardous air pollutants by over 70%. As wood dries, the escaping water evaporatively cools the wood. This cooling tapers off wood when the wood is nearly dry and the wood temperature rises. Thermal breakdown of the wood tissue occurs and VOCs are released. Raising the final wood moisture by only a few percentage points minimizes the temperature rise and reduces emissions. Evaporative cooling also impacts has implications for VOC release from wood fines. Flaking wood for OSB manufacture inevitable generates fines. Fines dry out rapidly because of their high surface area and evaporative cooling is lost more rapidly than for flakes. As a result, fines emit a disproportionate quantity of VOCs. Fines can be reduced in two ways: through screening of the green furnish and through reducing their generation during flaking. The second approach is preferable because it also increased wood yield. A procedure to do this by matching the sharpness angle of the flaker knife to the ambient temperature was also developed. Other findings of practical interests are as follows: Dielectric heating of wood under low-headspace conditions removes terpenes and other extractives from softwood; The monoterpene content in trees depend upon temperature and seasonal

  18. Structuring the AP Art History Course

    ERIC Educational Resources Information Center

    Herscher, Walter R.

    2013-01-01

    While AP (Advanced Placement) Art History may be taught within the art department in many schools, social studies teachers are equally capable of teaching the course well. They have the historical background to discuss the reasons for changes in art styles. A teacher's preparation is similar to teaching a course stressing political history,…

  19. APS deposition facility upgrades and future plans

    NASA Astrophysics Data System (ADS)

    Conley, Ray; Shi, Bing; Erdmann, Mark; Izzo, Scott; Assoufid, Lahsen; Goetze, Kurt; Mooney, Tim; Lauer, Kenneth

    2014-09-01

    The Advanced Photon Source (APS) has recently invested resources to upgrade or replace aging deposition systems with modern equipment. Of the three existing deposition systems, one will receive an upgrade, while two are being replaced. A design which adds a three-substrate planetary for the APS rotary deposition system is almost complete. The replacement for the APS large deposition system, dubbed the "Modular Deposition System", has been conceptually designed and is in the procurement process. Eight cathodes will sputter horizontally on mirrors up to 1.5 meters in length. This new instrument is designed to interface with ion-milling instruments and various metrology equipment for ion-beam figuring. A third linear machine, called the APS Profile Coating System, has two cathodes and is designed to accept substrates up to 200mm in length. While this machine is primarily intended for fabrication of figured KB mirrors using the profile-coating technique, it has also been used to produce multilayer monochromators for beamline use.

  20. The AP Descriptive Chemistry Question: Student Errors

    ERIC Educational Resources Information Center

    Crippen, Kent; Brooks, David W.

    2005-01-01

    For over a decade, the authors have been involved in a design theory experiment providing software for high school students preparing for the descriptive question on the Advanced Placement (AP) chemistry examination. Since 1997, the software has been available as a Web site offering repeatable practice. This study describes a 4-year project during…

  1. The Promise of AP World History

    ERIC Educational Resources Information Center

    Saldaña, Cristóbal T.

    2013-01-01

    AP World History is the ideal history course. It introduces students to 10,000 years of world history, and demands critical reading, critical writing, and critical thinking skills on the part of both the teacher and the students. It requires students to build their expertise in reading their textbook, and places demands on the teacher to assign…

  2. Gapminder: An AP Human Geography Lab Assignment

    ERIC Educational Resources Information Center

    Keller, Kenneth H.

    2012-01-01

    This lesson is designed as a lab assignment for Advanced Placement (AP) Human Geography students wherein they use the popular Gapminder web site to compare levels of development in countries from different world regions. For this lesson, it is important for the teacher to practice with Gapminder before giving the assignment to students. (Contains…

  3. Boosting Black Academic Achievement and AP Enrollments

    ERIC Educational Resources Information Center

    Saunders, Terrie; Maloney, Kathy

    2005-01-01

    Minority students were about 25% of the student population at Central High School in Omaha, Nebraska, in 1995. But the composition of its honors and challenge classes did not reflect this diversity: Few minority students were taking challenge classes as underclassmen and even fewer were taking Advanced Placement (AP) courses as seniors. This paper…

  4. College Board Readies Plans for AP Audits

    ERIC Educational Resources Information Center

    Klein, Alyson

    2006-01-01

    This article describes the educators mixed reviews regarding the audit system planned by the College Board to scrutinize high school Advanced Placement courses. Teachers of AP courses are required to submit materials to the College Board proving that their course syllabuses meet the program's curricular requirements. It is the most extensive…

  5. Two Successful Approaches to Teaching AP Government

    ERIC Educational Resources Information Center

    Ladd, Brian; Stepp, Heidi

    2013-01-01

    Amador Valley High School, in Pleasanton, California, uses two unique approaches to teaching Advanced Placement Government and Politics. AP Government consists of six units: Constitutional Underpinnings; Political Behavior and Political Beliefs; Mass Media, Interest Groups, and Political Parties; Institutions of Government; Civil Liberties and…

  6. The Demographic Wave: Rethinking Hispanic AP Trends

    ERIC Educational Resources Information Center

    Edwards, Kelcey; Sawtell, Ellen

    2013-01-01

    Presented at the Advanced Placement Annual Conference (APAC) in Las Vegas, NV in July 2013. This presentation reviews new research examining the AP® experience of Hispanic graduates over the past decade. Topics include an in-depth look at the AP Spanish Language and Culture gateway hypothesis and trends in family characteristics such as parent…

  7. Ap-let neurons--a peptidergic circuit potentially controlling ecdysial behavior in Drosophila.

    PubMed

    Park, Dongkook; Han, Mei; Kim, Young-Cho; Han, Kyung-An; Taghert, Paul H

    2004-05-01

    Here we describe a novel set of peptidergic neurons conserved throughout all developmental stages in the Drosophila central nervous system (CNS). We show that a small complement of 28 apterous-expressing cells (Ap-let neurons) in the ventral nerve cord (VNC) of Drosophila larvae co-express numerous gene products. The products include the neuroendocrine-specific bHLH regulator called Dimmed (Dimm), four neuropeptide biosynthetic enzymes (PC2, Fur1, PAL2, and PHM), and a specific dopamine receptor subtype (dDA1). For the PC2, Fur1, and PAL2 enzymes, and for the dDA1 receptor, this neuronal pattern represents the vast majority of their total expression in the VNC. In addition, while Dimm and PHM are present in the peritracheal Inka cells in larvae, pupae, and adults, Ap, PC2, Fur1, PAL2, and dDA1 are not. PC2, PAL2, and DA1 receptor expression were all controlled by both dimm and ap. Previous genetic analysis of animals deficient in PC2 revealed an abnormal larval ecdysis phenotype. Together, these data support the hypothesis that the small cohort of Ap-let interneurons regulates larval ecdysis behavior by secretion of an unidentified amidated peptide(s). This hypothesis further predicts that the production of the Ap-let neuropeptide(s) is dependent on each of four specific enzymes, and that a certain aspect(s) of its production and/or release is regulated by dopamine input. PMID:15081360

  8. Assimilation and implications of AE-9/AP-9 in the design process of JPL missions

    NASA Astrophysics Data System (ADS)

    de Soria-Santacruz Pich, M.; Jun, I.

    2015-12-01

    The NASA AE-8/AP-8 has been the standard geospace environment specification for decades. This model describes the energetic particle environment around the Earth and is currently the default model used in the design of space missions at the Jet Propulsion Laboratory (JPL). Moreover, the model plays a critical role in the determination of the shielding and survivability of the satellites orbiting our planet. A recent update supported by the Air Force Research Laboratory (AFRL) and the National Reconnaissance Office (NRO), the AE-9/AP-9 model, was released in September 2012 and included many improvements like increased spatial resolution and the specification of the uncertainty due to instrument errors or space weather variability. A current effort at JPL is in place with the objective of making a decision within the Laboratory on the transition from AE-8/AP-8 to the new AE-9/AP-9. In this study we present the results of this effort, which involves the comparison between both versions of the model for different satellite orbits, the comparison between AE-9/AP-9 and in-situ satellite data from the Van Allen Probes and the OSTM/Jason 2 satellite, and the implications of adopting the new model for spacecraft design in terms of survivability, shielding, single event effects, and spacecraft charging.

  9. Expanded Analysis of Hot Isostatic Pressed Iodine-Loaded Silver-Exchanged Mordenite

    SciTech Connect

    Jubin, R. T.; Bruffey, S. H.; Patton, K. K.

    2014-09-30

    Reduced silver-exchanged mordenite (Ag0Z) is being evaluated as a potential material to control the release of radioactive iodine that is released during the reprocessing of used nuclear fuel into the plant off-gas streams. The purpose of this study was to determine if hot pressing could directly convert this iodine loaded sorbent into a waste form suitable for long-term disposition. The minimal pretreatment required for production of pressed pellets makes hot pressing a technically and economically desirable process. Initial scoping studies utilized hot uniaxial pressing (HUPing) to prepare samples of non-iodine-loaded reduced silver exchanged mordenite (Ag0Z). The resulting samples were very fragile due to the low pressure (~ 28 MPa) used. It was recommended that hot isostatic pressing (HIPing), performed at higher temperatures and pressures, be investigated. HIPing was carried out in two phases, with a third and final phase currently underway. Phase I evaluated the effects of pressure and temperature conditions on the manufacture of a pressed sample. The base material was an engineered form of silver zeolite. Six samples of Ag0Z and two samples of I-Ag0Z were pressed. It was found that HIPing produced a pressed pellet of high density. Analysis of each pressed pellet by scanning electron microscopy-energy dispersive spectrophotometry (SEM-EDS) and X-ray diffraction (XRD) demonstrated that under the conditions used for pressing, the majority of the material transforms into an amorphous structure. The only crystalline phase observed in the pressed Ag0Z material was SiO2. For the samples loaded with iodine (I-Ag0Z) iodine was present as AgI clusters at low temperatures, and transformed into AgIO4 at high temperatures. Surface mapping and EDS demonstrate segregation between silver iodide phases and silicon dioxide phases. Based on the results of the Phase I study, an expanded test matrix was developed to examine the effects of multiple source materials, compositional

  10. Thermodynamics of Damaged DNA Binding and Catalysis by Human AP Endonuclease 1.

    PubMed

    Miroshnikova, A D; Kuznetsova, A A; Kuznetsov, N A; Fedorova, O S

    2016-01-01

    Apurinic/apyrimidinic (AP) endonucleases play an important role in DNA repair and initiation of AP site elimination. One of the most topical problems in the field of DNA repair is to understand the mechanism of the enzymatic process involving the human enzyme APE1 that provides recognition of AP sites and efficient cleavage of the 5'-phosphodiester bond. In this study, a thermodynamic analysis of the interaction between APE1 and a DNA substrate containing a stable AP site analog lacking the C1' hydroxyl group (F site) was performed. Based on stopped-flow kinetic data at different temperatures, the steps of DNA binding, catalysis, and DNA product release were characterized. The changes in the standard Gibbs energy, enthalpy, and entropy of sequential specific steps of the repair process were determined. The thermodynamic analysis of the data suggests that the initial step of the DNA substrate binding includes formation of non-specific contacts between the enzyme binding surface and DNA, as well as insertion of the amino acid residues Arg177 and Met270 into the duplex, which results in the removal of "crystalline" water molecules from DNA grooves. The second binding step involves the F site flipping-out process and formation of specific contacts between the enzyme active site and the everted 5'-phosphate-2'-deoxyribose residue. It was shown that non-specific interactions between the binding surfaces of the enzyme and DNA provide the main contribution into the thermodynamic parameters of the DNA product release step. PMID:27099790

  11. Functional description of APS beamline front ends

    SciTech Connect

    Kuzay, T.

    1993-02-01

    Traditional synchrotron sources were designed to produce bending magnet radiation and have proven to be an essential scientific tool. Currently, a new generation of synchrotron sources is being built that will be able to accommodate a large number of insertion device (ID) and high quality bending magnet (BM) sources. One example is the 7-GeV Advanced Photon Source (APS) now under construction at Argonne National Laboratory. The research and development effort at the APS is designed to fully develop the potential of this new generation of synchrotron sources. Of the 40 straight sections in the APS storage ring, 34 will be available for IDs. The remaining six sections are reserved for the storage ring hardware and diagnostics. Although the ring incorporates 80 BMs, only 40 of them can be used to extract radiation. The accelerator hardware shadows five of these 40 bending magnets, so the maximum number of BM sources on the lattice is 35. Generally, a photon beamline consists of four functional sections. The first section is the ID or the BM, which provides the radiation source. The second section, which is immediately outside the storage ring but inside a concrete shielding tunnel, is the front end, which is designed to control, define, and/or confine the x-ray beam. In the case of the APS, the front ends are designed to confine the photon beam. The third section, just outside the concrete shielding tunnel and on the experimental floor, is the first optics enclosure, which contains optics to filter and monochromatize the photon beam. The fourth section of a beamline consists of beam transports, additional optics, and experiment stations to do the scientific investigations. This document describes only the front ends of the APS beamlines.

  12. Improvement of touch sensitivity by pressing.

    PubMed

    Jeong, Hie-yong; Higashimori, Mitsuru; Kaneko, Makoto

    2008-01-01

    It is really interesting to know how a blood flow has an influence on a touch sensitivity during human fingertip exploration over an environment. In this paper, we examine experimentally how the touch sensitivity is changed under the condition that the blood flow is interrupted compulsorily by pressing the proximal phalange of human finger. Through the weight discrimination test based on Weber's Law, we found that the touch sensitivity improves temporarily with the statistical significance test of below 0.1 %, when a finger proximal phalange is bound and pressed. Experimental results also show that there exists a meaningful correlationship between the stiffness of fingertip and the touch sensitivity. PMID:19163188

  13. STS-121: Discovery Post Launch Press Briefing

    NASA Technical Reports Server (NTRS)

    2006-01-01

    The briefing begins with Dean Acousta (NASA Press Secretary) introducing Michael Griffin (NASA Administrator), Bill Gerstenmaier (Associate Administrator for Space Operations) Wayne Hale (Space Shuttle Program Manager), John Shannon (Chairman, Mission Management Team, JSC), and Mike Leinbach (NASA Launch Director). The teams effort and dedication paid off in the form of a perfect launch and the weather cooperated. The Mission Management Team no problems during inspection. Debris assessment at 2 min. 47 sec. and 4 min. 50 sec. will be discussed when that information becomes available.The floor was then open for questions from the press.

  14. Aerial view of the Press Site

    NASA Technical Reports Server (NTRS)

    1998-01-01

    In this aerial view, The News Center sits beyond a large parking lot, on a hill at the northeastern end of the Launch Complex 39 Area , next to the turn basin (at left). From left, the grandstand faces the launch pads several miles away on the Atlantic seashore; behind it, the television studio is the site of media conferences; next, the large white-roofed building is the hub of information and activity for press representatives. Lined up on the right of the Press Site are various buildings and trailers, home to major news networks. The parking lot can accommodate the hundreds of media personnel who attend Space Shuttle launches.

  15. Tank 241-AP-106, grab samples, 6AP-96-1 through 6AP-96-3 analytical results for the final report

    SciTech Connect

    Esch, R.A., Westinghouse Hanford

    1996-12-11

    This document is the final report for tank 241-AP-106 grab samples. This document presents the analytical results for three samples (6AP-96-1, 6AP-96-2 and 6AP-96-3) taken from riser 1 @ 150{degrees} of tank 241-AP-1 06 on September 12, 1996. Analyses were performed in accordance with the Compatibility Grab Sampling and Analysis Plan (TSAP) (Sasaki, 1996) and the Data Quality Objectives for Tank Farms Waste Compatibility Program (DQO) (Fowler, 1995).

  16. 7 CFR 58.421 - Press.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Press. 58.421 Section 58.421 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 AND THE...

  17. Does Science Get the Press It Deserves?

    ERIC Educational Resources Information Center

    Wilkie, Tom

    1991-01-01

    Discusses concerns about public understanding of science in the United Kingdom in relation to structure and content of newspapers, particularly the inadequacy of the press to be a vehicle for promoting scientific literacy within the citizenry. Argues that changes in science coverage by the media must originate from the scientific community with…

  18. When International Press Rights "Are" the News

    ERIC Educational Resources Information Center

    Freedman, Eric

    2006-01-01

    In many countries, reporters and editors face criminal prosecution, censorship, self-censorship, exile, tax audits, loss of broadcast and publication licenses, loss of jobs, assault, and even assassination based on how they practice their profession. Press rights and human rights advocacy groups try to draw media and official attention to those…

  19. Press Site Auditorium dedicated to John Holliman

    NASA Technical Reports Server (NTRS)

    1999-01-01

    A ceremony dedicated the KSC Press Site auditorium as the John Holliman Auditorium to honor the correspondent for his enthusiastic, dedicated coverage of America's space program. The auditorium was built in 1980 and has been the focal point for new coverage of Space Shuttle launches. The ceremony followed the 94th launch of a Space Shuttle, on mission STS-96, earlier this morning.

  20. Research Review: The Specialized Business Press.

    ERIC Educational Resources Information Center

    Endres, Kathleen L.

    1994-01-01

    Reviews scholarly research (from journalism, communication, business, and the humanities) on the specialized business press. Notes the lack of theory building and ties across disciplines, and anticipates that new advances in CD-ROM technology may increase research into the field as well as strengthen ties across disciplines. (SR)

  1. An Introduction to Bibliographical Press Work.

    ERIC Educational Resources Information Center

    Richardson, John V., Jr.

    This guide to the literature of bibliographical press work is comprised of brief introductory notes on the field and this bibliography, followed by citations listed in seven categories: (1) book production, (2) handmade paper, (3) printer's ink, (4) type design, (5) book design, (6) hand printing, and (7) hand bookbinding. Introductory as well as…

  2. U.S. BICENTENNIAL EXPOSITION PRESS CONFERENCE

    NASA Technical Reports Server (NTRS)

    1976-01-01

    Fielding questions from the press concerning 3rd Century America, the Bicentennial Exposition on Science and Technology are [left to right]: Herbert J. Rowe, NASA Associate Administrator for External Affairs; Miles Ross, KSC Deputy Director and Bicentennial General Manager; Lee Scherer, KSC Director, and Paul Donnelly, KSC Director of Space Transportation System Processing and Chief of the Exposition Site Development and Operations Office.

  3. 28 CFR 540.64 - Press pools.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... PERSONS IN THE COMMUNITY Contact With News Media § 540.64 Press pools. (a) The Warden may establish a... shall notify all news media representatives who have requested interviews or visits that have not been... national and international news services; (2) The television and radio networks and outlets; (3) The...

  4. 28 CFR 540.64 - Press pools.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... PERSONS IN THE COMMUNITY Contact With News Media § 540.64 Press pools. (a) The Warden may establish a... shall notify all news media representatives who have requested interviews or visits that have not been... national and international news services; (2) The television and radio networks and outlets; (3) The...

  5. 28 CFR 540.64 - Press pools.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... PERSONS IN THE COMMUNITY Contact With News Media § 540.64 Press pools. (a) The Warden may establish a... shall notify all news media representatives who have requested interviews or visits that have not been... national and international news services; (2) The television and radio networks and outlets; (3) The...

  6. Student Press Corps (Use the News).

    ERIC Educational Resources Information Center

    Mahler, Susan

    1989-01-01

    Describes the Student Press Corps, a program in which high school students submit weekly columns concerning local high school events for editing and possible publication by the local newspaper. Reports that training sessions have been fully enrolled for two years and that all participants are extremely positive about the program. (RS)

  7. Being Black in America: The Press Portrayal.

    ERIC Educational Resources Information Center

    Martindale, Carolyn

    Acknowledging inadequacies of press coverage of black Americans during this century, a study examined how a medium sized Ohio daily newspaper covered blacks before, during, and after the civil rights movement. Items concerning blacks in 66 issues of the Youngstown "Vindicator" from the 1950s, 1960s, and 1970s were studied, and the findings…

  8. Strategic Elites, the Press, and Race Relations.

    ERIC Educational Resources Information Center

    Domke, David

    2000-01-01

    Examines 2 important congressional debates about race relations, and the relationship of journalism to these debates, in the late 19th century. Suggests that political elites commonly used news, opinion, and perceptions in press content and by journalists to support, defend, and buttress certain policy positions in these debates. (SR)

  9. Free Press in a Constitutional Democracy

    ERIC Educational Resources Information Center

    Lucianek, Christine

    2014-01-01

    This article describes a lesson in which students will examine several views expressed by the founders to understand the context for including freedom of the press in the First Amendment. Students will be asked to think about the role that the news media and the need to be an informed citizen continue to play in our democracy. Students will…

  10. A Journalist's Guide to the Free Press.

    ERIC Educational Resources Information Center

    Ingelhart, Louis

    1996-01-01

    Summarizes the content of the federal constitution and various state constitutions regarding freedom of the press. Examines certain borderline issues, including actions and expressions, pornography, defamation, libel, and copyrighted material. States that regulation of unprotected material must be reasonable, specific, and clear. Discusses what…

  11. Communications in Agriculture: The American Farm Press.

    ERIC Educational Resources Information Center

    Evans, James F.; Salcedo, Rodolfo N.

    This book studies communications in agriculture, focusing on the American farm press. As defined here, a commercial farm periodical is directed to farmers and supports itself through the sale of subscriptions or advertising. It includes local as well as regional and national periodicals. A 90-year analysis, from 1880 to 1970, was chosen because…

  12. 7 CFR 58.421 - Press.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 3 2013-01-01 2013-01-01 false Press. 58.421 Section 58.421 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 AND THE...

  13. The Press Conferences of Eleanor Roosevelt.

    ERIC Educational Resources Information Center

    Beasley, Maurine H.

    Newly discovered transcriptions of 87 of First Lady Eleanor Roosevelt's women-only press conferences held from 1933 to 1945 make possible an examination of the objectives, topics, and value of these conferences. By holding the conferences, Mrs. Roosevelt attributed to women an important function in the political communication process, and at the…

  14. College Student Press Law. Second Edition.

    ERIC Educational Resources Information Center

    Trager, Robert; Dickerson, Donna L.

    This second edition of a monograph provides updated information on court decisions concerning college student publications and underground newspapers to acquaint advisers, administrators, and students with college student press law. Chapters of the monograph examine freedom of speech on the college campus; the relationship between colleges and…

  15. The Press, Privacy, and Community Mores.

    ERIC Educational Resources Information Center

    Glasser, Theodore L.

    Because of judicial indifference and legislative inaction, the conflict between the right of privacy and the freedom of the press is no closer to a resolution than it was a century ago. William Prosser's reduction of the common law of privacy into four separate torts has not solved the problem. The concept of "newsworthiness" has not been helpful…

  16. 28 CFR 540.64 - Press pools.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... PERSONS IN THE COMMUNITY Contact With News Media § 540.64 Press pools. (a) The Warden may establish a... shall notify all news media representatives who have requested interviews or visits that have not been... national and international news services; (2) The television and radio networks and outlets; (3) The...

  17. 28 CFR 540.64 - Press pools.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PERSONS IN THE COMMUNITY Contact With News Media § 540.64 Press pools. (a) The Warden may establish a... shall notify all news media representatives who have requested interviews or visits that have not been... national and international news services; (2) The television and radio networks and outlets; (3) The...

  18. STS-9 Spacelab 1 Press Kit

    NASA Technical Reports Server (NTRS)

    1983-01-01

    Press information on the STS-9/SPACELAB 1 mission is provided. Launch preparations, launch window, flight objectives, experiments, life sciences baseline data collection, SPACELAB 1 payload operations and control crew and specialists, and tracking and data management are among the topics explained.

  19. Holding fixture for a hot stamping press

    NASA Technical Reports Server (NTRS)

    Harris, R. P. (Inventor)

    1983-01-01

    A hand held guide for manually positioning a work piece between the anvil rib and tool of a hot die stamping press is described. A groove completed by interchangeable cover plates attached at one end of the guide conforms to a cross sectional dimension common to similar workpieces and, with a force fit, retentively holds each of the workpieces.

  20. Eye-Pressing by Visually Impaired Children.

    ERIC Educational Resources Information Center

    Jan, James E.; And Others

    1983-01-01

    The nature of eye-pressing as a visual stimulation mannerism in children with severely impaired eyesight is examined, and a possible physiological explanation (that self-stimulation occurs when the demand of the brain for meaningful visual information is not met) is offered. (CL)

  1. Accuracy of Press Reports in Astronomy

    NASA Astrophysics Data System (ADS)

    Schaefer, B. E.; Hurley, K.; Nemiroff, R. J.; Branch, D.; Perlmutter, S.; Schaefer, M. W.; Consolmagno, G. J.; McSween, H.; Strom, R.

    1999-12-01

    Most Americans learn about modern science from press reports, while such articles have a bad reputation among scientists. We have performed a study of 403 news articles on three topics (gamma-ray astronomy, supernovae, and Mars) to quantitatively answer the questions 'How accurate are press reports of astronomy?' and 'What fraction of the basic science claims in the press are correct?' We have taken all articles on the topics from five news sources (UPI, NYT, S&T, SN, and 5 newspapers) for one decade (1987-1996). All articles were evaluated for a variety of errors, ranging from the fundamental to the trivial. For 'trivial' errors, S&T and SN were virtually perfect while the various newspapers averaged roughly one trivial error every two articles. For meaningful errors, we found that none of our 403 articles significantly mislead the reader or misrepresented the science. So a major result of our study is that reporters should be rehabilitated into the good graces of astronomers, since they are actually doing a good job. For our second question, we rated each story with the probability that its basic new science claim is correct. We found that the average probability over all stories is 70%, regardless of source, topic, importance, or quoted pundit. How do we reconcile our findings that the press does not make significant errors yet the basic science presented is 30% wrong? The reason is that the nature of news reporting is to present front-line science and the nature of front-line science is that reliable conclusions have not yet been reached. So a second major result of our study is to make the distinction between textbook science (with reliability near 100%) and front-line science which you read in the press (with reliability near 70%).

  2. Kiln for hot-pressing compacts in a continuous manner

    DOEpatents

    Reynolds, C.D Jr.

    1983-08-08

    The invention is directed to a hot pressing furnace or kiln which is capable of preheating, hot pressing, and cooling a plurality of articles in a sequential and continuous manner. The hot pressing furnace of the present invention comprises an elongated, horizontally disposed furnace capable of holding a plurality of displaceable pusher plates each supporting a die body loaded with refractory or ceramic material to be hot pressed. Each of these plates and the die body supported thereby is sequentially pushed through the preheating zone, a temperature stabilizing and a hot pressing zone, and a cooling zone so as to provide a continuous hot-pressing operation of a plurality of articles.

  3. Kiln for hot-pressing compacts in a continuous manner

    DOEpatents

    Reynolds, Jr., Carl D.

    1985-01-01

    The present invention is directed to a hot pressing furnace or kiln which is capable of preheating, hot pressing, and cooling a plurality of articles in a sequential and continuous manner. The hot pressing furnace of the present invention comprises an elongated, horizontally disposed furnace capable of holding a plurality of displaceable pusher plates each supporting a die body loaded with refractory or ceramic material to be hot pressed. Each of these plates and the die body supported thereby is sequentially pushed through the preheating zone, a temperature stabilizing and a hot pressing zone, and a cooling zone so as to provide a continuous hot-pressing operation of a plurality of articles.

  4. STS-26 Preflight Press Briefing: Shuttle System Changes. Part 2 of 9

    NASA Technical Reports Server (NTRS)

    1988-01-01

    This NASA KSC video release presents a press conference that discusses the major system changes implemented on the shuttle in preparation for the launch of Discovery STS-26. Richard A. Colonna (Mgr. Orbiter and GFE Projects office) and an unidentified colleague present discussions involving hazard analysis, landing safety, launch abort/crew escape and major modidfications made to the Space Shuttle Boosters. Their presentations are followed by a question and answer period for journalists from scientific journals.

  5. Cultural Diversity in AP Art History

    ERIC Educational Resources Information Center

    Bolte, Frances R.

    2006-01-01

    Teaching AP Art History is like running on a treadmill that is moving faster than a teacher can run. Many teachers are out of breath before the end of the term and wonder how in the world they can cover every chapter. Because time is short and art from pre-history through to the present, including the non-European traditions, must be covered, this…

  6. An Updated AP2 Beamline TURTLE Model

    SciTech Connect

    Gormley, M.; O'Day, S.

    1991-08-23

    This note describes a TURTLE model of the AP2 beamline. This model was created by D. Johnson and improved by J. Hangst. The authors of this note have made additional improvements which reflect recent element and magnet setting changes. The magnet characteristics measurements and survey data compiled to update the model will be presented. A printout of the actual TURTLE deck may be found in appendix A.

  7. Beryllium window for an APS diagnostics beamline

    SciTech Connect

    Sheng, I.C.; Yang, B.X.; Sharma, Y.S.

    1997-09-01

    A beryllium (Be) window for an Advanced Photon Source (APS) diagnostics beamline has been designed and built. The window, which has a double concave axisymmetrical profile with a thickness of 0.5 mm at the center, receives 160 W/mm{sup 2} (7 GeV/100 mA stored beam) from an undulator beam. The window design as well as thermal and thermomechanical analyses, including thermal buckling of the Be window, are presented.

  8. APS storage ring vacuum system performance

    SciTech Connect

    Noonan, J.R.; Gagliano, J.; Goeppner, G.A.

    1997-06-01

    The Advanced Photon Source (APS) storage ring was designed to operated with 7-GeV, 100-mA positron beam with lifetimes > 20 hours. The lifetime is limited by residual gas scattering and Touschek scattering at this time. Photon-stimulated desorption and microwave power in the rf cavities are the main gas loads. Comparison of actual system gas loads and design calculations will be given. In addition, several special features of the storage ring vacuum system will be presented.

  9. Final report for tank 241-AP-108, grab samples 8AP-96-1, 8AP-96-2 and 8AP-96-FB

    SciTech Connect

    Esch, R.A.

    1996-04-19

    This document is the final report deliverable for the tank 241-AP-108 grab samples. The samples were subsampled and analyzed in accordance with the TSAP. Included in this report are the results for the Waste Compatibility analyses, with the exception of DSC and thermogravimetric analysis (TGA) results which were presented in the 45 Day report (Part 2 of this document). The raw data for all analyses, with the exception of DSC and TGA, are also included in this report.

  10. AP-42 ADDITIONS AND REVISIONS - RESIDENTIAL WOOD COMBUSTION

    EPA Science Inventory

    This project develops emission factors, etc., for residential fireplaces and woodstoves which are incorporated into AP-42. AP42 is a massive collection of material which describes processes which generate air emissions and presents emission factors and control effectiveness infor...

  11. Small Molecule Inhibitors Targeting Activator Protein 1 (AP-1)

    PubMed Central

    2015-01-01

    Activator protein 1 (AP-1) is a pivotal transcription factor that regulates a wide range of cellular processes including proliferation, apoptosis, differentiation, survival, cell migration, and transformation. Accumulating evidence supports that AP-1 plays an important role in several severe disorders including cancer, fibrosis, and organ injury, as well as inflammatory disorders such as asthma, psoriasis, and rheumatoid arthritis. AP-1 has emerged as an actively pursued drug discovery target over the past decade. Excitingly, a selective AP-1 inhibitor T-5224 (51) has been investigated in phase II human clinical trials. Nevertheless, no effective AP-1 inhibitors have yet been approved for clinical use. Despite significant advances achieved in understanding AP-1 biology and function, as well as the identification of small molecules modulating AP-1 associated signaling pathways, medicinal chemistry efforts remain an urgent need to yield selective and efficacious AP-1 inhibitors as a viable therapeutic strategy for human diseases. PMID:24831826

  12. Streptolysin-O induces release of glycosylphosphatidylinositol-anchored alkaline phosphatase from ROS cells by vesiculation independently of phospholipase action.

    PubMed Central

    Xie, M; Low, M G

    1995-01-01

    Streptolysin-O (SLO), a cholesterol-binding agent, was used for studies on the release of glycosylphosphatidylinositol (GPI)-anchored alkaline phosphatase (AP) from ROS cells. Treatment of cells with SLO resulted in a time- and concentration-dependent release of AP into the extracellular medium. This release was potentiated by Ca2+ and bovine serum, but not by GPI-specific phospholipase D (GPI-PLD) purified from bovine serum. The released AP distributed to the detergent phase after Triton X-114 phase separation. This result suggested that the released AP contained an intact GPI anchor, and thus both proteolysis and anchor degradation by anchor-specific hydrolases, including GPI-PLD, as the potential mechanisms for SLO-mediated AP release were ruled out. The released AP sedimented at 100,000 g. A substantial amount of lipids was detected in the 100,000 g pellet. Cholesterol and sphingomyelin were enriched in SLO-released material, compared with intact cells. These results were consistent with vesiculation as the mechanism for SLO induction of AP release. Two other cholesterol-binding agents, saponin and digitonin, were also able to release AP, possibly by a similar vesiculation mechanism, whereas others, including nystatin, filipin and beta-escin, failed to elicit any AP release. Eight GPI-anchored proteins were identified in ROS cells, and all were substantially enriched in the vesicles released by SLO. Taken together, these results do not provide any support for the hypothesis that the clustering of GPI-anchored proteins in the plasma membrane is responsible for their resistance to GPI-PLD cleavage. Images Figure 5 Figure 6 PMID:7832771

  13. 9. INTERIOR VIEW OF EYE PRESS AREA; TO LEFT IS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. INTERIOR VIEW OF EYE PRESS AREA; TO LEFT IS A TWO-BAY SLOTTED TYPE FURNACE, TO CENTER IS EYE PRESS, TO RIGHT IS CURCULAR SAW - Warwood Tool Company, Foot of Nineteenth Street, Wheeling, Ohio County, WV

  14. 19. VIEW OF MOUNTING PRESS, showing removal of water guard ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. VIEW OF MOUNTING PRESS, showing removal of water guard prior to dismounting from press. Gary Stich, operator. - Juniata Shops, Erecting Shop & Machine Shop, East of Fourth Avenue, between Fourth & Fifth Streets, Altoona, Blair County, PA

  15. METHOD FOR SOLVENT-ISOSTATIC PRESSING

    DOEpatents

    Archibald, P.B.

    1962-09-18

    This invention provides a method for producing densely compacted bodies having relatively large dimensions. The method comprises the addition of a small quantity of a suitable solvent to a powder which is to be compacted. The solvent- moistened powder is placed inside a flexible bag, and the bag is suspended in an isostatic press. The solvent is squeezed out of the powder by the isostatic pressure, and the resulting compacted body is recovered. The presence of the solvent markedly decreases the proportion of void space in the powder, thereby resulting in a denser, more homogeneous compact. Another effect of the solvent is that it allows the isostatic pressing operation to be conducted at substantially lower pressures than are conventionally employed. (AEC)

  16. Method for hot pressing beryllium oxide articles

    DOEpatents

    Ballard, Ambrose H.; Godfrey, Jr., Thomas G.; Mowery, Erb H.

    1988-01-01

    The hot pressing of beryllium oxide powder into high density compacts with little or no density gradients is achieved by employing a homogeneous blend of beryllium oxide powder with a lithium oxide sintering agent. The lithium oxide sintering agent is uniformly dispersed throughout the beryllium oxide powder by mixing lithium hydroxide in an aqueous solution with beryllium oxide powder. The lithium hydroxide is converted in situ to lithium carbonate by contacting or flooding the beryllium oxide-lithium hydroxide blend with a stream of carbon dioxide. The lithium carbonate is converted to lithium oxide while remaining fixed to the beryllium oxide particles during the hot pressing step to assure uniform density throughout the compact.

  17. Reducing VOC Press Emission from OSB Manufacturing

    SciTech Connect

    Dr. Gary D. McGinnis; Laura S. WIlliams; Amy E. Monte; Jagdish Rughani: Brett A. Niemi; Thomas M. Flicker

    2001-12-31

    Current regulations require industry to meet air emission standards with regard to particulates, volatile organic compounds (VOCs), hazardous air pollutants (HAPs) and other gases. One of many industries that will be affected by the new regulations is the wood composites industry. This industry generates VOCs, HAPs, and particulates mainly during the drying and pressing of wood. Current air treatment technologies for the industry are expensive to install and operate. As regulations become more stringent, treatment technologies will need to become more efficient and cost effective. The overall objective of this study is to evaluate the use of process conditions and chemical additives to reduce VOC/HAPs in air emitted from presses and dryers during the production of oriented strand board.

  18. [Ashi points, Ashi method and pressing reaction].

    PubMed

    Wang, Zhao-hui; Zhang, Zhi-feng; Ding, Xiao-jun; Zhou, Chang-le

    2011-04-01

    The nomination of Ashi points was reviewed, and the meaning of Ashi method was discussed in this article. On the base of further study on Huangdi Neijing (The Yellow Emperor's Canon of Internal Medicine), the general meaning of palpation at acupoints, meridians and collaterals to the process of acupoint locating were expounded. The concept of pressing reaction was proposed as well. It is held that Ashi points are a category of acupoints without specific names and definite locations. They are a kind of manifestation of reactions of acupoints, meridians and collaterals, which embody their dynamic features. Pressing reaction mainly manifested by sensations of comfort, pain, and moreover, relieving of the primary symptoms. It is the most basic evidence for us to estimate Ashi points. PMID:21528600

  19. 77 FR 24480 - Application for New Awards; Advanced Placement (AP) Test Fee Program-Reopening the AP Test Fee...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-24

    .... ACTION: Notice reopening the AP Test Fee fiscal year 2012 competition. Catalog of Federal Domestic Assistance (CFDA) Number: 84.330B. SUMMARY: On February 15, 2012, we published in the Federal Register (77 FR... Application for New Awards; Advanced Placement (AP) Test Fee Program--Reopening the AP Test Fee Fiscal...

  20. Effect of enzyme-aided cell wall disintegration on protein extractability from intact and dehulled rapeseed (Brassica rapa L. and Brassica napus L.) press cakes.

    PubMed

    Rommi, Katariina; Hakala, Terhi K; Holopainen, Ulla; Nordlund, Emilia; Poutanen, Kaisa; Lantto, Raija

    2014-08-13

    Cell-wall- and pectin-degrading enzyme preparations were used to enhance extractability of proteins from rapeseed press cake. Rapeseed press cakes from cold pressing of intact Brassica rapa and partially dehulled Brassica napus seeds, containing 36-40% protein and 35% carbohydrates, were treated with pectinolytic (Pectinex Ultra SP-L), xylanolytic (Depol 740L), and cellulolytic (Celluclast 1.5L) enzyme preparations. Pectinex caused effective disintegration of embryonic cell walls through hydrolysis of pectic polysaccharides and glucans and increased protein extraction by up to 1.7-fold in comparison to treatment without enzyme addition. Accordingly, 56% and 74% of the total protein in the intact and dehulled press cakes was extracted. Light microscopy of the press cakes suggested the presence of pectins colocalized with proteins inside the embryo cells. Hydrolysis of these intracellular pectins and deconstruction of embryonic cell walls during Pectinex treatment were concluded to relate with enhanced protein release. PMID:25039585

  1. Graphic Arts: The Press and Finishing Processes. Third Edition.

    ERIC Educational Resources Information Center

    Crummett, Dan

    This document contains teacher and student materials for a course in graphic arts concentrating on printing presses and the finishing process for publications. Seven units of instruction cover the following topics: (1) offset press systems; (2) offset inks and dampening chemistry; (3) offset press operating procedures; (4) preventive maintenance…

  2. Freedom of the Press in an International Perspective. Teaching Strategy.

    ERIC Educational Resources Information Center

    Miller, Barbara

    1997-01-01

    Presents a lesson plan that compares freedom of the press in the United States and other countries. Reveals the extent to which the First Amendment protects press freedom from abuses found in other countries. Includes a world map illustrating areas enjoying freedom of the press, and related statistical tables. (MJP)

  3. Through the Looking Glass: Press Responses to Genocide.

    ERIC Educational Resources Information Center

    Lipstadt, Deborah E.

    1991-01-01

    Examines press coverage of the Holocaust to analyze the response of the United States and the world to the Jewish extermination. Compares this coverage to earlier press responses to the Armenian genocide and Ukraine famines. Argues the press was unwilling to face the Holocaust's magnitude. Urges teachers to teach about the Holocaust and similar…

  4. The Rice University Press Initiative: An Interview with Charles Henry

    ERIC Educational Resources Information Center

    Trevitte, Chad; Henry, Charles

    2007-01-01

    In this interview Charles Henry, publisher of the Rice University Press (RUP), discusses RUP's rebirth as a fully digital university press. Henry addresses the circumstances that led to this decision, and he further outlines the RUP business model whereby the press will publish its own titles--both digitally and in print-on-demand--while…

  5. The Press, Japanese Americans, and the Concentration Camps.

    ERIC Educational Resources Information Center

    Okihiro, Gary Y.; Sly, Julie

    1983-01-01

    A study of the wartime press suggests that the plan to incarcerate Japanese Americans (under Executive Order 9066) was government-initiated, that the public and the press initially disapproved of such treatment, and that events emanating from the government influenced shifts in press and public opinion that allowed implementation of the plan.…

  6. Living Dangerously--Changing Press Law in India.

    ERIC Educational Resources Information Center

    Ryan, Timothy

    An examination of the changes in press laws after India gained its independence in 1947 shows how a free press is shaped mostly by the structure and evolution of the democratic society that it is intended to serve. The most salient features that have characterized the Indian press, from the early nineteenth century to the present day, are…

  7. The American Native Press and American Indian Studies.

    ERIC Educational Resources Information Center

    Littlefield, Daniel F., Jr.

    1986-01-01

    As product and process, the Native American press has a long history. The establishment of the first native-run press in 1828 began a press history that continues today. That history is represented by more than 2,000 periodical titles alone, two-thirds of which have been established during the past 20 years. Impressive collections of these…

  8. The Historical Importance of Jury to Press Freedom.

    ERIC Educational Resources Information Center

    Olasky, Marvin N.

    Staggered by some recent libel verdicts, many journalists are neglecting lessons about press freedom learned at great cost during the seventeenth and eighteenth centuries. Journalists then learned that state power over the press, residing in the hands of either censors or judges, leads to a decrease in press freedom. In 1986, though, many media…

  9. Ozone mitigation tests at the APS

    SciTech Connect

    Kuzay, T.M.; Collins, J.T.; Pisharody, M.; Job, P.K.; Wang Zhibi

    1996-09-01

    Ozone is generated in the APS experimental stations whenever the x-ray beam has a chance to interact with air. Ozone concentrations in an experimental station have to be below a certain defined limit (current OSHA regulations specify 0.08 ppm as the maximum limit) before an experimenter can reenter the hutch. This limit is said to be currently under study for a downward adjustment. One method of depleting the ozone generated in an experimental station is mitigation through either adsorption or direct destruction. In recent tests, both methods were tried using commercially available units. Test results and some analytical predictions are presented.

  10. Toggle release

    NASA Technical Reports Server (NTRS)

    Graves, Thomas Joseph (Inventor); Yang, Robert Alexander (Inventor); Brown, Christopher William (Inventor)

    1988-01-01

    The invention relates to a pyrotechnic actuated release mechanism which is mechanically two fault tolerant for effecting release. It is particularly well suited for releasably connecting structures to be used in the space environment or in other aerospace applications. The device comprises a fastener plate and fastener body, each attachable to either one of a pair of structures to be joined. The fastener plate and the body are fastenable by a toggle supported at one end on the fastener plate and mounted for universal pivotal movement thereon. At its other end, which is received in a central opening in the fastener body and adapted for limited pivotal movement therein, the toggle is restrained by three retractable latching pins. Each pin is individually retractable by combustion of a pyrotechnic charge. While retraction of all three pins releases the toggle, the fastener is mechanically two fault tolerant since the failure of any single or pair of the latch pins to retract results in an asymmetrical loading on the toggle and its pivotal movement to effect a release. An annular bolt is mounted on the fastener plate as a support for the socket mounting of the toggle whereby its selective axial movement provides a means for pre-loading the toggle.

  11. The Inter American Press Association as Champion of Press Freedom: Reality or Rhetoric? The Bolivian Experience, 1952-1973.

    ERIC Educational Resources Information Center

    Knudson, Jerry W.

    Each year a committee on freedom of the press, established in 1946 by the Inter American Press Association (IAPA), exposes those countries which it feels do not have freedom of the press. In 1952 Bolivia underwent a social and economic revolution. As a result, angry mobs forced the closure of the two newspapers with the largest circulation in…

  12. Electromagnetic field analysis of septum magnet for APS positron accumulator ring

    SciTech Connect

    Yokoi, Toshiaki; Turner, L.R.

    1995-07-01

    This report consists of three parts. The first part describes a numerical analysis method for the electromagnetic field analysis of a septum magnet. A novel improvement to the treatment of exciting currents in the time-domain is proposed. The second part discusses numerical predictions of the electromagnetic characteristics of the APS PAR septum. The time variations of stray field and eddy currents are shown for three magnet designs. The last part explores how decreasing the septum material conductivity affects the stray field. The decrease of conductivity may be caused by an inadequate manufacturing of the septum material. The significance of a high quality septum, or flat interface between copper and iron, is emphasized from a point of view of stray field. An ideal method for joining two different metals without distortion, called HIP (Hot Isostatic Pressing), is introduced and recommended based on the authors` experience.

  13. Modulation of dopamine release in the striatum by physiologically relevant levels of nicotine.

    PubMed

    Wang, Li; Shang, Shujiang; Kang, Xinjiang; Teng, Sasa; Zhu, Feipeng; Liu, Bin; Wu, Qihui; Li, Mingli; Liu, Wei; Xu, Huadong; Zhou, Li; Jiao, Ruiying; Dou, Haiqiang; Zuo, Panli; Zhang, Xiaoyu; Zheng, Lianghong; Wang, Shirong; Wang, Changhe; Zhou, Zhuan

    2014-01-01

    Striatal dopamine (DA) release can be independently triggered not only by action potentials (APs) in dopaminergic axons but also APs in cholinergic interneurons (ChIs). Nicotine causes addiction by modulating DA release, but with paradoxical findings. Here, we investigate how physiologically relevant levels of nicotine modulate striatal DA release. The optogenetic stimulation of ChIs elicits DA release, which is potently inhibited by nicotine with an IC50 of 28 nM in the dorsal striatum slice. This ChI-driven DA release is predominantly mediated by α6β2* nAChRs. Local electrical stimulus (Estim) activates both dopaminergic axons and ChIs. Nicotine does not affect the AP(DA)-dependent DA release (AP(DA), AP of dopaminergic axon). During burst Estim, nicotine permits the facilitation of DA release by prevention of DA depletion. Our work indicates that cholinergic stimulation-induced DA release is profoundly modulated by physiologically relevant levels of nicotine and resolves the paradoxical observation of nicotine's effects on striatal DA release. PMID:24968237

  14. Correction magnet power supplies for APS machine

    SciTech Connect

    Kang, Y.G.

    1991-04-01

    A number of correction magnets are required for the advanced photon source (APS) machine to correct the beam. There are five kinds of correction magnets for the storage ring, two for the injector synchrotron, and two for the positron accumulator ring (PAR). Table I shoes a summary of the correction magnet power supplies for the APS machine. For the storage ring, the displacement of the quadrupole magnets due to the low frequency vibration below 25 Hz has the most significant effect on the stability of the positron closed orbit. The primary external source of the low frequency vibration is the ground motion of approximately 20 {mu}m amplitude, with frequency components concentrated below 10 Hz. These low frequency vibrations can be corrected by using the correction magnets, whose field strengths are controlled individually through the feedback loop comprising the beam position monitoring system. The correction field require could be either positive or negative. Thus for all the correction magnets, bipolar power supplies (BPSs) are required to produce both polarities of correction fields. Three different types of BPS are used for all the correction magnets. Type I BPSs cover all the correction magnets for the storage ring, except for the trim dipoles. The maximum output current of the Type I BPS is 140 Adc. A Type II BPS powers a trim dipole, and its maximum output current is 60 Adc. The injector synchrotron and PAR correction magnets are powered form Type III BPSs, whose maximum output current is 25 Adc.

  15. The APS control system network upgrade.

    SciTech Connect

    Sidorowicz, K. v.; Leibfritz, D.; McDowell, W. P.

    1999-10-22

    When it was installed,the Advanced Photon Source (APS) control system network was at the state-of-the-art. Different aspects of the system have been reported at previous meetings [1,2]. As loads on the controls network have increased due to newer and faster workstations and front-end computers, we have found performance of the system declining and have implemented an upgraded network. There have been dramatic advances in networking hardware in the last several years. The upgraded APS controls network replaces the original FDDI backbone and shared Ethernet hubs with redundant gigabit uplinks and fully switched 10/100 Ethernet switches with backplane fabrics in excess of 20 Gbits/s (Gbps). The central collapsed backbone FDDI concentrator has been replaced with a Gigabit Ethernet switch with greater than 30 Gbps backplane fabric. Full redundancy of the system has been maintained. This paper will discuss this upgrade and include performance data and performance comparisons with the original network.

  16. Effect of hot pressing additives on the leachability of hot pressed sodium hydrous titanium oxide

    SciTech Connect

    Valentine, T.M.; Sambell, R.A.J.

    1980-01-01

    Sodium hydrous titanium oxide is an ion exchange resin which can be used for immobilizing medium level waste (MLW) liquors. When hot pressed, it undergoes conversion to a ceramic. Three low melting point materials (borax, bismuth trioxide, and a mixture of PbO/CuO) were added to the (Na)HTiO and the effect that each of these had on aiding densification was assessed. Hot pressing temperature, applied pressure, and percentage addition of hot pressing aid were varied. Percentage open porosity, flexural strength, and leachability were measured. There was a linear relationship between the percentage open porosity and the logarithm of the leach rate for a constant percentage addition of each additive.

  17. EX-PRESS Glaucoma Filtration Device: efficacy, safety, and predictability

    PubMed Central

    Chan, Jessica E; Netland, Peter A

    2015-01-01

    Trabeculectomy has been the traditional primary surgical therapy for open-angle glaucoma. While trabeculectomy is effective in lowering intraocular pressure, complications associated with the procedure have motivated the development of alternative techniques and devices, including the EX-PRESS Glaucoma Filtration Device. This review describes the efficacy, safety, complication rates, and potential advantages and disadvantages of the EX-PRESS Glaucoma Filtration Device. EX-PRESS implantation is technically simpler compared with that of trabeculectomy, with fewer surgical steps. Vision recovery has been more rapid after EX-PRESS implantation compared with trabeculectomy. Intraocular pressure variation is lower during the early postoperative period, indicating a more predictable procedure. While efficacy of the EX-PRESS implant has been comparable to trabeculectomy, postoperative complications appear less common after EX-PRESS implantation compared with trabeculectomy. The EX-PRESS Glaucoma Filtration Device appears to be safe and effective in the surgical management of open-angle glaucoma. PMID:26366105

  18. EPA’s AP-42 development methodology: Converting or rerating current AP-42 datasets

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In August 2013, the U.S. Environmental Protection Agency’s (EPA) published their new methodology for updating the Compilation of Air Pollution Emission Factors (AP-42). The “Recommended Procedures for Development of Emissions Factors and Use of the WebFIRE Database” instructs that the ratings of the...

  19. Evaluating EPA’s AP-42 development methodology to convert or rerate current AP-42 datasets

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In August 2013, the U.S. Environmental Protection Agency’s (EPA) published their new methodology for updating the Compilation of Air Pollution Emission Factors (AP-42). The “Recommended Procedures for Development of Emissions Factors and Use of the WebFIRE Database” instructs that the ratings of the...

  20. Toggle release

    NASA Technical Reports Server (NTRS)

    Graves, Thomas J. (Inventor); Yang, Robert A. (Inventor); Brown, Christopher W. (Inventor)

    1989-01-01

    A pyrotechnic actuated structural release device 10 which is mechanically two fault tolerant for release. The device 10 comprises a fastener plate 11 and fastener body 12, each attachable to a different one of a pair of structures to be joined. The fastener plate 11 and body 12 are fastenable by a toggle 13 supported at one end on the fastener plate and mounted for universal pivotal movement thereon. At its other end which is received in a central opening in the fastener body 12 and adapted for limited pivotal movement therein the toggle 13 is restrained by three retractable latching pins 61 symmetrically disposed in equiangular spacing about the axis of the toggle 13 and positionable in latching engagement with an end fitting on the toggle. Each pin 61 is individually retractable by combustion of a pyrotechnic charge 77, the expanding gases of which are applied to a pressure receiving face 67 on the latch pin 61 to effect its retraction from the toggle. While retraction of all three pins 62 releases the toggle, the fastener is mechanically two fault tolerant since the failure of any single one or pair of the latch pins to retract results in an asymmetrical loading on the toggle and its pivotal movement to effect a release. An annular bolt 18 is mounted on the fastener plate 11 as a support for the socket mounting 30, 37 of the toggle whereby its selective axial movement provides a means for preloading the toggle.

  1. Retention of deuterium implanted into B 4C-overlaid isotropic graphites and hot-pressed B 4C

    NASA Astrophysics Data System (ADS)

    Jimbou, R.; Saidoh, M.; Ogiwara, N.; Ando, T.; Morita, K.; Muto, Y.

    1992-12-01

    Retention characteristics of two kinds of B 4C-overlaid graphites and hot-pressed B 4C were investigated. An ion beam of 3 keV D 2+ was implanted into the specimens at room temperature. The amount of retained deuteriums was measured as function of the implantation fluence and temperature by elastic recoil detection analysis. Thermal release behavior of implanted deuteriums was also measured by isochronal annealing. The concentration of retained deuterium reaches saturation similarly in three kinds of B 4C-overlaid specimens at the fluences over 10 18 D +/cm 2 as in isotropic graphite. The release temperature, at which the number of retained deuterium decreases to one half in isochronal annealing, are about 250 K lower for three kinds of B 4C specimens than for graphite. The release temperature of deuterium from unsaturated hot-pressed B 4C in isochronal annealing is about 500 K higher than that from saturated one.

  2. [The press as a vehicle for the introduction of a fashionable disease].

    PubMed

    Meulenberg, F

    2003-09-01

    Two journalists wrote a book on HPU (haemopyrrol-lactamuria), a hitherto unknown metabolic disease that was alleged to cause a whole range of complaints. The book is based on the ideas of a biochemist who is also the director of a commercial organisation that offers a diagnostic test as well as a therapy (nutrition supplement) for HPU. The release of the book was accompanied by a press release that provoked various publications in both biomedical journals and the lay press. In response to these reports, the director sometimes registered a complaint with the Dutch Council for Journalism, but on other occasions he did not. The content of this book is in no way based on scientific research. In retrospect, it is obvious that the authors, the biochemist and the publishing company have joint commercial ties. All professional standards of scientific research and journalistic decency are thus being violated. In this way, they are doing harm to the independence and integrity of researchers and journalists in the public image. All the activities of the press seem to have been an essential part of a deliberate marketing strategy for the introduction of a non-disease. PMID:14520803

  3. Press or pulse exposures determine the environmental fate of cerium nanoparticles in stream mesocosms.

    PubMed

    Baker, Leanne F; King, Ryan S; Unrine, Jason M; Castellon, Benjamin T; Lowry, Gregory V; Matson, Cole W

    2016-05-01

    Risk-assessment models indicate that stream ecosystems receiving municipal wastewater effluent may have the greatest potential for exposure to manufactured nanoparticles. The authors determined the fate of cerium oxide (CeO2 ) nanoparticles in outdoor stream mesocosms using 1) 1-time pulse addition of CeO2 nanoparticles, representative of accidental release, and 2) continuous, low-level press addition of CeO2 nanoparticles, representative of exposure via wastewater effluent. The pulse addition led to rapid nanoparticle floc formation, which appeared to preferentially deposit on periphyton in low-energy areas downstream from the location of the input, likely as a result of gravitational sedimentation. Floc formation limited the concentration of suspended nanoparticles in stream water to <5% of target and subsequent downstream movement. In contrast, press addition of nanoparticles led to higher suspended nanoparticle concentrations (77% of target) in stream water, possibly as a result of stabilization of suspended nanoparticles through interaction with dissolved organic carbon. Smaller nanoparticle aggregates appeared to preferentially adsorb to stream surfaces in turbulent sections, where Ce concentrations were highest in the press, likely a result of stochastic encounter with the surface. Streams receiving wastewater effluent containing nanoparticles may lead to exposure of aquatic organisms over a greater spatial extent than a similar amount of nanoparticles from an accidental release. Exposure models must take into account these mechanisms controlling transport and depositional processes. Environ Toxicol Chem 2016;35:1213-1223. © 2015 SETAC. PMID:26576038

  4. Method for hot press forming articles

    DOEpatents

    Baker, Robert R.; Hartsock, Dale L.

    1982-01-01

    This disclosure relates to an improved method for achieving the best bond strength and for minimizing distortion and cracking of hot pressed articles. In particular, in a method for hot press forming both an outer facing circumferential surface of and an inner portion of a hub, and of bonding that so-formed outer facing circumferential surface to an inner facing circumferential surface of a pre-formed ring thereby to form an article, the following improvement is made. Normally, in this method, the outside ring is restrained by a restraining sleeve of ring-shaped cross-section having an inside diameter. A die member, used to hot press form the hub, is so-formed as to have an outside diameter sized to engage the inside diameter of the restraining sleeve in a manner permitting relative movement therebetween. The improved method is one in which several pairs of matched restraining sleeve and die member are formed with each matched pair having a predetermined diameter. The predetermined diameter of each matched pair is different from another matched pair by stepped increments. The largest inside diameter of a restraining sleeve is equal to the diameter of the outer facing circumferential surface of the hub. Each pair of the matched restraining sleeve and die member is used to form an article in which an inside hub is bonded to an outside ring. The several samples so-formed are evaluated to determine which sample has the best bond formed between the hub and the ring with the least or no cracking or distortion in the ring portion of the article. Thereafter, the matched restraining sleeve and die member which form the article having the best bonding characteristics and least distortion cracking is then used for repeated formations of articles.

  5. EIA new releases, November--December 1995

    SciTech Connect

    1996-02-09

    Thus publication contains information compiled by the Energy information administration (EIA) on the following topics: heating fuel supplies; alternative fuel vehicles; natural gas production; clean air laws and coal transportation; EIA`s world Wide Web Site; EIA`s CD-ROM; Press Releases; Microfiched products; electronic publishing; new reports; machine-readable files; how to order EIA publications; and Energy Data Information Contracts.

  6. Press Site Auditorium dedicated to John Holliman

    NASA Technical Reports Server (NTRS)

    1999-01-01

    From left, Center Director Roy Bridges and NASA Administrator Daniel S. Goldin applaud as Jay Holliman, with the help of his mother, Mrs. Dianne Holliman, unveils a plaque honoring his father, the late John Holliman. At right is Tom Johnson, news group chairman of CNN. The occasion was the dedication of the KSC Press Site auditorium as the John Holliman Auditorium to honor the CNN national correspondent for his enthusiastic, dedicated coverage of America's space program. The auditorium was built in 1980 and has been the focal point for new coverage of Space Shuttle launches. The ceremony followed the 94th launch of a Space Shuttle, on mission STS-96, earlier this morning.

  7. Press Site Auditorium dedicated to John Holliman

    NASA Technical Reports Server (NTRS)

    1999-01-01

    NASA Administrator Daniel S. Goldin hands Mrs. Dianne Holliman a plaque honoring her late husband, John Holliman, a CNN national correspondent. Standing behind Goldin is Center Director Roy Bridges. At right is Tom Johnson, news group chairman of CNN. A ceremony dedicated the KSC Press Site auditorium as the John Holliman Auditorium to honor the correspondent for his enthusiastic, dedicated coverage of America's space program. The auditorium was built in 1980 and has been the focal point for new coverage of Space Shuttle launches. The ceremony followed the 94th launch of a Space Shuttle, on mission STS-96, earlier this morning.

  8. STS-99 / Endeavour: Launch Postponement Press Conference

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Live footage shows Ron Dittemore, the Shuttle Program Manager from Johnson Space Center (JSC), participating in a Launch Postponement Press Conference disclosing the status of the STS-99 flight. He addresses the weather condition which caused the postponement and the erroneous response from one of the Master Events Controllers (MEC). The moderator of this conference is Bruce Buckingham from NASA's Public Affairs Office. Ron answers questions from the audience about the MEC responsible for sending commands for launch, and the implications that it might have on the launch schedule.

  9. A single β adaptin contributes to AP1 and AP2 complexes and clathrin function in Dictyostelium.

    PubMed

    Sosa, R Thomas; Weber, Michelle M; Wen, Yujia; O'Halloran, Theresa J

    2012-02-01

    The assembly of clathrin-coated vesicles is important for numerous cellular processes, including nutrient uptake and membrane organization. Important contributors to clathrin assembly are four tetrameric assembly proteins, also called adaptor proteins (APs), each of which contains a β subunit. We identified a single β subunit, named β1/2, that contributes to both the AP1 and AP2 complexes of Dictyostelium. Disruption of the gene encoding β1/2 resulted in severe defects in growth, cytokinesis and development. Additionally, cells lacking β1/2 displayed profound osmoregulatory defects including the absence of contractile vacuoles and mislocalization of contractile vacuole markers. The phenotypes of β1/2 null cells were most similar to previously described phenotypes of clathrin and AP1 mutants, supporting a particularly important contribution of AP1 to clathrin pathways in Dictyostelium cells. The absence of β1/2 in cells led to significant reductions in the protein amounts of the medium-sized subunits of the AP1 and AP2 complexes, establishing a role for the β subunit in the stability of the medium subunits. Dictyostelium β1/2 could resemble a common ancestor of the more specialized β1 and β2 subunits of the vertebrate AP complexes. Our results support the essential contribution of a single β subunit to the stability and function of AP1 and AP2 in a simple eukaryote. PMID:22050483

  10. Thermodynamics of Damaged DNA Binding and Catalysis by Human AP Endonuclease 1

    PubMed Central

    Miroshnikova, A. D.; Kuznetsova, A. A.; Kuznetsov, N. A.; Fedorova, O. S.

    2016-01-01

    Apurinic/apyrimidinic (AP) endonucleases play an important role in DNA repair and initiation of AP site elimination. One of the most topical problems in the field of DNA repair is to understand the mechanism of the enzymatic process involving the human enzyme APE1 that provides recognition of AP sites and efficient cleavage of the 5’-phosphodiester bond. In this study, a thermodynamic analysis of the interaction between APE1 and a DNA substrate containing a stable AP site analog lacking the C1’ hydroxyl group (F site) was performed. Based on stopped-flow kinetic data at different temperatures, the steps of DNA binding, catalysis, and DNA product release were characterized. The changes in the standard Gibbs energy, enthalpy, and entropy of sequential specific steps of the repair process were determined. The thermodynamic analysis of the data suggests that the initial step of the DNA substrate binding includes formation of non-specific contacts between the enzyme binding surface and DNA, as well as insertion of the amino acid residues Arg177 and Met270 into the duplex, which results in the removal of “crystalline” water molecules from DNA grooves. The second binding step involves the F site flipping-out process and formation of specific contacts between the enzyme active site and the everted 5’-phosphate-2’-deoxyribose residue. It was shown that non-specific interactions between the binding surfaces of the enzyme and DNA provide the main contribution into the thermodynamic parameters of the DNA product release step. PMID:27099790

  11. Radiation characteristics of scintillator coupled CMOS APS for radiography conditions

    NASA Astrophysics Data System (ADS)

    Kim, Kwang Hyun; Kim, Soongpyung; Kang, Dong-Won; Kim, Dong-Kie

    2006-11-01

    Under industrial radiography conditions, we analyzed short-term radiation characteristics of scintillator coupled CMOS APS (hereinafter SC CMOS APS). By means of experimentation, the contribution of the transmitted X-ray through the scintillator to the properties of the CMOS APS and the afterimage, generated in the acquired image even at low dose condition, were investigated. To see the transmitted X-ray effects on the CMOS APS, Fein focus™ X-ray machine, two scintillators of Lanex™ Fine and Regular, and two CMOS APS array of RadEye™ were used under the conditions of 50 kV p/1 mAs and 100 kV p/1 mAs. By measuring the transmitted X-ray on signal and Noise Power Spectrum, we analytically examined the generation mechanism of the afterimage, based on dark signal or dark current increase in the sensor, and explained the afterimage in the SC CMOS APS.

  12. Abstracts of Suburban Press Critique Series Papers Produced by the Suburban Press Research Center from April 1966 to May 1973. Suburban Press Research Series No. 15.

    ERIC Educational Resources Information Center

    Northern Illinois Univ., De Kalb. Suburban Press Research Center.

    Abstracts of 28 articles, collected by the Suburban Press Research Center, are provided in this paper. The articles discuss various aspects of the suburban press: pretrial coverage; news coverage for adolescents, the family, and the aged; editorials; education news; business news; crime coverage; consumer information; the formation of policies…

  13. Control units for APS power supplies

    SciTech Connect

    Despe, O.D.; Saunders, C.; McGhee, D.G.

    1993-07-01

    The Advanced Photon Source (APS) accelerator facility is made up of five major subsystems in addition to the linac: the positron accumulator ring (PAR), low energy transport (LET), booster synchrotron (SYNCH), high energy transport (HET), the storage ring (SR). Each subsystem has multiple magnet power supply combinations, some requiring multiple of operation. These magnet and power supply combinations computer controlled and monitored. The power supply control unit (PSCU) is the first layer of hardware and software above the power supply itself and is described in this paper. The description includes the basic philosophy for each of operation and how it influences the topology and of implementing control. The design of the analog reference blocks (ARBs) influenced the design of other custom functions well as the feedback controls for vibration and other dynamic corrections. The command set supported by the PSCU is discussed.

  14. The Ebb and Flow of the Liberalization of the Jordanian Press: 1985-1997.

    ERIC Educational Resources Information Center

    Najjar, Orayb Aref

    1998-01-01

    Contributes to scholarship on the complexities of press freedom in non-Western nations. Discusses the context of press freedom in Jordan; the press before the 1989 liberalization; factors that favored press liberalization in 1989; the 1993 press law; the "Temporary Law for the Year 1997"; press reaction to the amendments; and factors mitigating…

  15. Apollo 11 Astronauts During Press Conference

    NASA Technical Reports Server (NTRS)

    1969-01-01

    The night before launch day, Apollo 11 crew members (R-L) Michael Collins, Neil Armstrong, and Edwin Aldrin, participated in a closed circuit press conference the night before they began their historic lunar landing mission. At far left is chief astronaut and director of flight crew operations, Donald K. Slayton. The press conference with questions via intercom, was held under semi-isolation conditions to avoid exposing the astronauts to possible illness at the last minute. The Apollo 11 mission, the first lunar landing mission, launched from the Kennedy Space Center (KSC) in Florida via the Marshall Space Flight Center (MSFC) developed Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. Aboard the space craft were astronauts Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. (Buzz) Aldrin Jr., Lunar Module (LM) pilot. The CM, 'Columbia', piloted by Collins, remained in a parking orbit around the Moon while the LM, 'Eagle'', carrying astronauts Armstrong and Aldrin, landed on the Moon. On July 20, 1969, Armstrong was the first human to ever stand on the lunar surface, followed by Aldrin. During 2½ hours of surface exploration, the crew collected 47 pounds of lunar surface material for analysis back on Earth. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished.

  16. Project W-211, initial tank retrieval systems, description of operations for 241-AP-102 and 241-AP-104

    SciTech Connect

    RIECK, C.A.

    1999-02-25

    The primary purpose of the Initial Tank Retrieval Systems (ITRS) is to provide systems for retrieval of radioactive wastes stored in underground double-shell tanks (DSTS) for transfer to alternate storage, evaporation, pretreatment or treatment, while concurrently reducing risks associated with safety watch list and other DSTs. This Description of Operations (DOO) defines the control philosophy for the waste retrieval system for tanks 241-AP-102 (AP-102) and 241-AP-104 (AP-104). This DOO will provide a basis for the detailed design of the Retrieval Control System (RCS) for AP-102 and AP-104 and establishes test criteria for the RCS. The test criteria will be used during qualification testing and acceptance testing to verify operability.

  17. Summary of Calcine Disposal Development Using Hot Isostatic Pressing

    SciTech Connect

    Bateman, Ken; Wahlquist, Dennis; Hart, Edward; McCartin, William

    2015-03-01

    Battelle Energy Alliance, LLC, has demonstrated the effectiveness of the hot isostatic press (HIP) process for treatment of hazardous high-level waste known as calcine that is stored at the Idaho Nuclear Technology and Engineering Center (INTEC) at Idaho National Laboratory. HIP trials performed with simulated calcines at Idaho National Laboratory’s Materials and Fuels Complex and an Australian Nuclear Science and Technology Organization facility from 2007 to 2010 produced a dense, monolithic waste form with increased chemical durability and effective (storage) volume reductions of ~10 to ~70% compared to granular calcine forms. In December 2009, the U.S. Department of Energy signed an amended Record of Decision selecting HIP technology as the treatment method for the 4,400 m3 of granular zirconia and alumina calcine stored at INTEC. Testing showed that HIP treatment reduces the risks associated with radioactive and hazardous constituent release, post-production handling, and long-term (repository) storage of calcines and would result in estimated storage cost savings in the billions of dollars. Battelle Energy Alliance has the ability to complete pilot-scale HIP processing of INTEC calcine, which is the next necessary step in implementing HIP processing as a calcine treatment method.

  18. Direct drive digital servo press with high parallel control

    NASA Astrophysics Data System (ADS)

    Murata, Chikara; Yabe, Jun; Endou, Junichi; Hasegawa, Kiyoshi

    2013-12-01

    Direct drive digital servo press has been developed as the university-industry joint research and development since 1998. On the basis of this result, 4-axes direct drive digital servo press has been developed and in the market on April of 2002. This servo press is composed of 1 slide supported by 4 ball screws and each axis has linearscale measuring the position of each axis with high accuracy less than μm order level. Each axis is controlled independently by servo motor and feedback system. This system can keep high level parallelism and high accuracy even with high eccentric load. Furthermore the 'full stroke full power' is obtained by using ball screws. Using these features, new various types of press forming and stamping have been obtained by development and production. The new stamping and forming methods are introduced and 'manufacturing' need strategy of press forming with high added value and also the future direction of press forming are also introduced.

  19. Post flight press conference for the STS-7 mission

    NASA Technical Reports Server (NTRS)

    1983-01-01

    Two of the three mission specialists for STS-7 field questions from the press during the post-flight press conference in JSC's main auditorium on July 1, 1983. Left to right are John M. Fabian and Dr. Norman E. Thagard (35419); Portrait view of Fabian during the STS-7 post-flight press conference (35420); Portrait view of mission specialist Dr. Sally K. Ride during the STS-7 post-flight press conference (35421); Portrait view of STS-7 pilot Frederick H. Hauck during the post-flight press conference (35422); Portrait view of STS-7 crew commander Robert L. Crippen during the post-flight press conference (35423); Three STS-7 crew members listen to questions from news reporters. They are, left to right, Crippen, Hauck, and Ride (35424); The first five person shuttle crew and first woman crew member greet the news media. Members are, left to right, Crippen, Hauck, Ride, Fabian and Thagard (35425).

  20. The AP2-like gene NsAP2 from water lily is involved in floral organogenesis and plant height.

    PubMed

    Luo, Huolin; Chen, Sumei; Jiang, Jiafu; Teng, Nianjun; Chen, Yu; Chen, Fadi

    2012-07-01

    APETALA2 (AP2) genes are ancient and widely distributed among the seed plants, and play an important role during the plant life cycle, acting as key regulators of many developmental processes. In this study, an AP2 homologue, NsAP2, was characterized from water lily (Nymphaea sp. cv. 'Yellow Prince') and is believed to be rather primitive in the evolution of the angiosperms. In situ RNA hybridization showed that NsAP2 transcript was present in all regions of the floral primordium, but had the highest level in the emerging floral organ primordium. After the differentiation of floral organs, NsAP2 was strongly expressed in sepals and petals, while low levels were found in stamens and carpels. The NsAP2 protein was suggested to be localized in the cell nucleus by onion transient expression experiment. Overexpression of NsAP2 in Arabidopsis led to more petal numbers, and Arabidopsis plants expressing NsAP2 exhibited higher plant height, which may be a result of down-regulated expression of GA2ox2 and GA2ox7. Our results indicated that the NsAP2 protein may function in flower organogenesis in water lily, and it is a promising gene for plant height improvement. PMID:22591856

  1. Genome-Wide Identification of the Target Genes of AP2-O, a Plasmodium AP2-Family Transcription Factor.

    PubMed

    Kaneko, Izumi; Iwanaga, Shiroh; Kato, Tomomi; Kobayashi, Issei; Yuda, Masao

    2015-05-01

    Stage-specific transcription is a fundamental biological process in the life cycle of the Plasmodium parasite. Proteins containing the AP2 DNA-binding domain are responsible for stage-specific transcriptional regulation and belong to the only known family of transcription factors in Plasmodium parasites. Comprehensive identification of their target genes will advance our understanding of the molecular basis of stage-specific transcriptional regulation and stage-specific parasite development. AP2-O is an AP2 family transcription factor that is expressed in the mosquito midgut-invading stage, called the ookinete, and is essential for normal morphogenesis of this stage. In this study, we identified the genome-wide target genes of AP2-O by chromatin immunoprecipitation-sequencing and elucidate how this AP2 family transcription factor contributes to the formation of this motile stage. The analysis revealed that AP2-O binds specifically to the upstream genomic regions of more than 500 genes, suggesting that approximately 10% of the parasite genome is directly regulated by AP2-O. These genes are involved in distinct biological processes such as morphogenesis, locomotion, midgut penetration, protection against mosquito immunity and preparation for subsequent oocyst development. This direct and global regulation by AP2-O provides a model for gene regulation in Plasmodium parasites and may explain how these parasites manage to control their complex life cycle using a small number of sequence-specific AP2 transcription factors. PMID:26018192

  2. Genome-Wide Identification of the Target Genes of AP2-O, a Plasmodium AP2-Family Transcription Factor

    PubMed Central

    Kaneko, Izumi; Iwanaga, Shiroh; Kato, Tomomi; Kobayashi, Issei; Yuda, Masao

    2015-01-01

    Stage-specific transcription is a fundamental biological process in the life cycle of the Plasmodium parasite. Proteins containing the AP2 DNA-binding domain are responsible for stage-specific transcriptional regulation and belong to the only known family of transcription factors in Plasmodium parasites. Comprehensive identification of their target genes will advance our understanding of the molecular basis of stage-specific transcriptional regulation and stage-specific parasite development. AP2-O is an AP2 family transcription factor that is expressed in the mosquito midgut-invading stage, called the ookinete, and is essential for normal morphogenesis of this stage. In this study, we identified the genome-wide target genes of AP2-O by chromatin immunoprecipitation-sequencing and elucidate how this AP2 family transcription factor contributes to the formation of this motile stage. The analysis revealed that AP2-O binds specifically to the upstream genomic regions of more than 500 genes, suggesting that approximately 10% of the parasite genome is directly regulated by AP2-O. These genes are involved in distinct biological processes such as morphogenesis, locomotion, midgut penetration, protection against mosquito immunity and preparation for subsequent oocyst development. This direct and global regulation by AP2-O provides a model for gene regulation in Plasmodium parasites and may explain how these parasites manage to control their complex life cycle using a small number of sequence-specific AP2 transcription factors. PMID:26018192

  3. Metallized solid rocket propellants based on AN/AP and PSAN/AP for access to space

    NASA Astrophysics Data System (ADS)

    Levi, S.; Signoriello, D.; Gabardi, A.; Molinari, M.; Galfetti, L.; Deluca, L. T.; Cianfanelli, S.; Klyakin, G. F.

    2009-09-01

    Solid rocket propellants based on dual mixes of inorganic crystalline oxidizers (ammonium nitrate (AN) and ammonium perchlorate (AP)) with binder and a mixture of micrometric-nanometric aluminum were investigated. Ammonium nitrate is a low-cost oxidizer, producing environment friendly combustion products but with lower specific impulse compared to AP. The better performance obtained with AP and the low quantity of toxic emissions obtained by using AN have suggested an interesting compromise based on a dual mixture of the two oxidizers. To improve the thermal response of raw AN, different types of phase stabilized AN (PSAN) and AN/AP co-crystals were investigated.

  4. The Multianvil Press Research Facility at GSECARS

    NASA Astrophysics Data System (ADS)

    Wang, Y.; Uchida, T.; Rivers, M. L.; Sutton, S. R.; Weidner, D. J.; Durham, W. B.

    2002-12-01

    The multianvil press high pressure synchrotron research facility at the GSECARS beamlines consists of two large-volume presses (LVP): a 2.5 MN (250 ton) system at the bending magnet beamline (13-BM-D) and a 10 MN system at the insertion device beamline (13-ID-D). Both systems are now fully operational, with steadily increasing annual usage from ~70 days in 1998 to ~120 days in 2001. Here we present a system overview with brief scientific highlights illustrating the breadth of research and achievements made using this facility. Construction and operation of the facility are supported by the NSF Geosciences Instrumentation and Facilities Program. A DIA-type cubic-anvil apparatus and a split-cylinder apparatus (T-Cup) with 10 mm WC cubes are used to generate pressures and temperatures up to 24 GPa and 2400 K, on millimeter-sized samples, at 13-BM-D. In 13-ID-D, a large T-Cup apparatus with 25 mm anvils is used to reach pressure and temperature conditions of 25 GPa and 2500K simultaneously. Both high-pressure apparatus are mounted in die-sets, which can be easily transported in and out of the hydraulic press. Therefore all pressure generating apparatus can be used at any beamline, depending on research needs. A new deformation DIA (DDIA) was commissioned in August, 2002. This apparatus is capable of generating 30% strain on a 1 mm sample at pressures to ~15 GPa, allowing quantitative triaxial deformation experiments. Close to 400 runs have been carried out at our facility in a wide range of research areas: (1) P-V-T equation of state measurements on important mantle minerals, Fe alloys, and pressure standards, (2) in situ determination of phase relations of silicates, Fe alloys, and semiconductors using X-ray diffraction, (3) falling sphere measurements using radiography to determine viscosity of the silicate and metallic melts, (4) ultrasonic velocity measurements on mantle minerals, especially non-quenchable high pressure phases (e.g., high-pressure clinoenstatite

  5. 30. BUILDING NO. 527, DEHYDRATING PRESSES, LOOKING SOUTH. ALUMINUM NARROWGUAGE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    30. BUILDING NO. 527, DEHYDRATING PRESSES, LOOKING SOUTH. ALUMINUM NARROW-GUAGE GONDOLA CAR IN LEFT BACKGROUND BROUGHT MOISTENED GUN COTTON FROM REST HOUSE (BUILDING NO. 320-B) IN CANS. (ONE OF THESE CANS IS ON UNLOADING PLATFORM RUNNING BESIDE PRESSES). CONTENTS OF CANS WERE UNLOADED INTO PRESSES BY HAND. - Picatinny Arsenal, 500 Area, Powder Factory & Power House, State Route 15 near I-80, Dover, Morris County, NJ

  6. Using selenomethionyl derivatives to assign sequence in low-resolution structures of the AP2 clathrin adaptor

    PubMed Central

    Kelly, Bernard T.; Graham, Stephen C.; Owen, David J.

    2016-01-01

    Selenomethionine incorporation is a powerful technique for assigning sequence to regions of electron density at low resolution. Genetic introduction of methionine point mutations and the subsequent preparation and crystallization of selenomethionyl derivatives permits unambiguous sequence assignment by enabling the placement of the anomalous scatterers (Se atoms) thus introduced. Here, the use of this approach in the assignment of sequence in a part of the AP2 clathrin adaptor complex that is responsible for clathrin binding is described. AP2 plays a pivotal role in clathrin-mediated endocytosis, a tightly regulated process in which cell-surface transmembrane proteins are internalized from the plasma membrane by incorporation into lipid-enclosed transport vesicles. AP2 binds cargo destined for internalization and recruits clathrin, a large trimeric protein that helps to deform the membrane to produce the transport vesicle. By selenomethionine labelling of point mutants, it was shown that the clathrin-binding site is buried within a deep cleft of the AP2 complex. A membrane-stimulated conformational change in AP2 releases the clathrin-binding site from autoinhibition, thereby linking clathrin recruitment to membrane localization. PMID:26960121

  7. Hot Isostatic Pressing of 60-Nitinol

    NASA Technical Reports Server (NTRS)

    Stanford, Malcolm K.

    2015-01-01

    The effects of varying the time, temperature and pressure during consolidation of 60-Nitinol (Nickel Titanium alloy) by hot isostatic pressing (HIP) were examined. Six HIP cycles with a cycle time of either 2 or 20 hours, temperature of 900 or 1000 degrees Centigrade, and a chamber pressure of either 100 or 200 millipascals were used. The cycle representing the shortest cycle time at the highest temperature and pressure (2 hours/1000 degrees Centigrade/200 millipascals) produced material with the highest hardness (720 Vickers Pyramid Number (HV)). A modest increase in average grain size and significant porosity reduction were observed in material subjected to the longest cycle time at the highest temperature, regardless of the pressure applied. The intent of this study is to facilitate the technology transfer involved in the processing of this material.

  8. STS-114: Discovery Launch Postponement Press Briefing

    NASA Technical Reports Server (NTRS)

    2005-01-01

    This press briefing addresses the problem that occurred prior to the launch of the STS-114. Dean Acosta, Deputy Assistant Administrator of Public Affairs, introduces the panel which consists of Dr. Michael Griffin, NASA Administrator, William Readdy, Associate Administrator for Space Operations, Wayne Hale, Space Shuttle Program Deputy Manager, Steve Poulas, Orbiter Project Manager, Mike Leinbach, NASA Launch Director, and Bill Parsons, Space Shuttle Program Manager. Wayne Hale expresses that a problem occurred with one of the low level sensors in the hydrogen tank and that the cause of the problem must be identified and rectified. Steve Poulos talks about establishing a troubleshooting plan as a part of the scrub effort and Mike Leinbach describes the process of draining the external tank. Wayne Hale answers questions about the sensors and if the Space Shuttle Discovery is safe to fly and Steve Poulos answers questions about the possible suspects for this problem.

  9. STS-114: Post Launch Press Conference

    NASA Technical Reports Server (NTRS)

    2005-01-01

    Dean Acosta, Deputy Assistant Administrator for Public Affairs hosted this post launch press conference. Present were Mike Griffin, NASA Administrator; William Ready, Associate Administrator for Space Operations; Bill Parsons, Space Shuttle Program Manager; Mike Leinbach, NASA Launch Director; and Wayne Hill, Deputy Program Manager for Space Shuttle Program. Each expressed thanks to all of NASA Officials and employees, contractors, vendors and the crew for their hard work the past two and a half years that resulted the successful and pristine launch of Space Shuttle Discovery. The Panel emphasized that through extensive technical analysis, thorough planning and tremendous amount of public support brought them full circle again to return to flight. Flight safety, debris during rocket separation, sensors, observations from the mission control, launch conditions were some of the topics discussed with the News media.

  10. STS-103 Discovery Launch Scrub Press Conference

    NASA Technical Reports Server (NTRS)

    1999-01-01

    A press conference held on December 16, 1999, to explain the reason behind NASA's decision to delay the Discovery's launching by a period of 24 hrs is presented. According to Ron Dittemore, Space Shuttle Program Manager, the STS-103 team delayed the launch because they need extra time to check one vendor's manufacturing processes, after an x-ray inspection revealed that an improper weld rod was used to weld one of the pressuring lines (called NPS lines) in the ET (external tank). Mr. Dittemore explained that since it is in the ET (not a major load carrying structure and rebuild after each flight), it did not pose any danger to the STS-103 flight. However, the same vendor also manufactured some parts of the orbiter and the team wanted to make sure that the quality of the vendor's manufacturing processes is robust before launching the orbiter to space. He also answered some reporters' questions.

  11. Publishing Outside the Box: Popular Press Books.

    PubMed

    Vyse, Stuart

    2014-10-01

    Writing and publishing popular press books requires a set of skills, not natural to basic and applied researchers trained to publish in peer-referred behavior analytic journals or to practice behavior analysis in applied settings. This article provides suggestions and examples. These include finding a distinctive idea, securing a contract, hiring an agent (or not), deciding on a publisher, and writing engagingly for a broad audience. The last is the greatest challenge. Among my recommendations are to read good prose, good models, and good books about publishing; talk to experienced colleagues; read aloud to judge the appropriateness of your vocabulary and style; and interject humor, imagery, and drama. Book publishing is a long and difficult process, but it is possible. It has a great potential for bringing behavior analytic research, practice and theory to the attention of the general public. PMID:27274959

  12. Residual radiation studies at AP0

    SciTech Connect

    Alexander J Elwyn et al.

    2002-06-19

    The radiation environment at the NuMI experiment has received a lot of attention in the last few years in preparation for project construction. One important issue is the induced radioactivation of the components in the beam line and the shielding materials. This arises from irradiation by hadrons that are generated in the target. Since the level of the residual activity has to be considered when determining access procedures for maintenance during NuMI operation, an understanding of the properties of the remnant radiation is important. To this end, experimental studies were performed in the target vault at AP0 which is similar in design to the NuMI target area. Here 120 GeV protons bombard a target, generating the hadrons that produce the induced radioactivity. Two sets of samples each consisting of three small cylindrical or rectangular solids of iron and steel, one sample of aluminum, and one of concrete were irradiated. One set was hung just below the bottom of a module near the lithium lens (in-vault), and the other was placed on top of the modules downstream of this location (above-vault), just beneath the movable concrete roof of the vault at AP0. Further, four thin activation foils of Au, Au+Cd, In, and Al (along with small disks of the same iron, aluminum, and concrete samples discussed above) were mounted on four 10.2 cm diameter Al disks, one placed on the in-vault module and three at above-vault downstream locations as well. The radioactivity of all these materials on the 10.2 cm Al disks was determined at the Radioisotope Analysis Facility in an attempt to characterize the radionuclides produced during irradiation. The activities of the thin foils were employed in an effort to unfold a spectrum of the neutrons produced during the hadronic cascades in the target. The MARS Monte Carlo code (MO95, MO00) was used to predict and analyze the residual radiation produced during the beam irradiation. New subroutines have been developed for the MARS14 version

  13. A comparative study between spiral-filter press and belt press implemented in a cloudy apple juice production process.

    PubMed

    De Paepe, Domien; Coudijzer, Katleen; Noten, Bart; Valkenborg, Dirk; Servaes, Kelly; De Loose, Marc; Diels, Ludo; Voorspoels, Stefan; Van Droogenbroeck, Bart

    2015-04-15

    In this study, advantages and disadvantages of the innovative, low-oxygen spiral-filter press system were studied in comparison with the belt press, commonly applied in small and medium size enterprises for the production of cloudy apple juice. On the basis of equivalent throughput, a higher juice yield could be achieved with spiral-filter press. Also a more turbid juice with a higher content of suspended solids could be produced. The avoidance of enzymatic browning during juice extraction led to an attractive yellowish juice with an elevated phenolic content. Moreover, it was found that juice produced with spiral-filter press demonstrates a higher retention of phenolic compounds during the downstream processing steps and storage. The results demonstrates the advantage of the use of a spiral-filter press in comparison with belt press in the production of a high quality cloudy apple juice rich in phenolic compounds, without the use of oxidation inhibiting additives. PMID:25466116

  14. AP-102/104 Retrieval control system qualification test procedure

    SciTech Connect

    RIECK, C.A.

    1999-05-18

    This Qualification Test Procedure documents the results of the qualification testing that was performed on the Project W-211, ''Initial Tank Retrieval Systems,'' retrieval control system (RCS) for tanks 241-AP-102 and 241-AP-104. The results confirm that the RCS has been programmed correctly and that the two related hardware enclosures have been assembled in accordance with the design documents.

  15. Is the Shine off the A.P. Apple?

    ERIC Educational Resources Information Center

    Hurwitz, Nina; Hurwitz, Sol

    2003-01-01

    Describes challenges facing College Board's efforts to expand Advanced Placement (A.P.) courses to provide equal access to previously underserved low-performing urban and rural school students while maintaining the program's high academic standards. Includes list of strategies school boards can use to achieve greater access to A.P. courses while…

  16. AP233: An Information Model for Systems Engineering

    NASA Technical Reports Server (NTRS)

    Siebes, Georg

    2009-01-01

    In today's world, information is abundant. We have no problems generating it. But we are challenged to find, organize, and exchange information. center dot A standardized model of information can help. Such a model nearly completed its development for Systems Engineering. It is referred to as AP233 (AP = Application Protocol).

  17. Status of the Advanced Photon Source (APS) linear accelerator

    SciTech Connect

    White, M.; Berg, W.; Fuja, R.; Grelick, A.; Mavrogenes, G.; Nassiri, A.; Russell, T.; Wesolowski, W.

    1993-08-01

    A 2856-MHz S-band, 450-MeV electron/positron linear accelerator is the first part of the injector for the Advanced Photon Source (APS) 7-GeV storage ring. Construction of the APS linac is currently nearing completion, and commissioning will begin in July 1993. The linac and its current status are discussed in this paper.

  18. Raising Rigor, Getting Results: Lessons Learned from AP Expansion

    ERIC Educational Resources Information Center

    Wakelyn, David

    2009-01-01

    Advanced Placement (AP), which enables high school students to take introductory college-level courses, is the nation's oldest example of a rigorous, common curriculum. Students who score well on AP exams are more likely to persist in college and earn a degree. The Advanced Placement Expansion project of the National Governors Association Center…

  19. The APS SASE FEL : modeling and code comparison.

    SciTech Connect

    Biedron, S. G.

    1999-04-20

    A self-amplified spontaneous emission (SASE) free-electron laser (FEL) is under construction at the Advanced Photon Source (APS). Five FEL simulation codes were used in the design phase: GENESIS, GINGER, MEDUSA, RON, and TDA3D. Initial comparisons between each of these independent formulations show good agreement for the parameters of the APS SASE FEL.

  20. AP-42 ADDITIONS AND REVISIONS - RUBBER PRODUCTS MANUFACTURING

    EPA Science Inventory

    This project develops emission factors, etc., for the rubber products industry which are appended to AP-42. AP42 is a massive collection of material which describes processes which generate air emissions and presents emission factors and control effectiveness information. As res...

  1. A Closer Examination of the Academic Benefits of AP

    ERIC Educational Resources Information Center

    McKillip, Mary E. M.; Rawls, Anita

    2013-01-01

    The authors sought to better understand the relationship between students participating in the Advanced Placement (AP) program and subsequent performance on the Scholastic Aptitude Test (SAT). Focusing on students graduating from U.S. public high schools in 2010, the authors used propensity scores to match junior year AP examinees in 3 subjects to…

  2. AP-42 ADDITIONS AND REVISIONS - LANDFILLS (COMBUSTION CONTROLS)

    EPA Science Inventory

    This project develops emission factors, etc., for landfills, in particular for combustion devices fed by landfill gas, for incorporation into AP-42. AP-42 is a massive collection of information concerning processes which generate air emissions and presents emission factors and co...

  3. Performance of Project Advance Students on the AP Biology Examination.

    ERIC Educational Resources Information Center

    Mercurio, Joseph; And Others

    1984-01-01

    Compared performance of Project Advance biology students (N=60) with Advanced Placement (AP) candidates (N=15,947) nationally on College Entrance Examination Board AP biology test. The research, conducted to determine comparability of the program as valid measures of academic achievement, determined that Project Advance students scored above the…

  4. Data-Based Decision Making: The Road to AP Equity

    ERIC Educational Resources Information Center

    Edwards, Kelcey; Duggan, Odette

    2012-01-01

    Presented at the Advanced Placement Annual Conference (APAC) in Lake Buena Vista, FL in July 2012. This presentation reviews concepts central to achieving equitable AP access and success for all willing and academically prepared students. We analyze trends in participation and performance by race/ethnicity from the AP Report to the Nation and…

  5. The AP Exam: Is This How People Learn?

    NASA Astrophysics Data System (ADS)

    Eisenkraft, Arthur

    2001-04-01

    The AP Physics course is often the most rigorous experience a student will have in high school. The culminating AP exam tests problem solving skills using traditional questions that are found in most freshmen books. The nature of the test imparts a specific focus on the course, which in turn shapes the students' impression of physics. Over the past decade, we have been discovering a great deal about how people learn in general. We have also learned specifically about the inadequacies of traditional physics instruction. Has the AP exam kept pace with this new knowledge? Can the AP exam be altered in order to require a different type of instruction that is informed by cognitive research? What would the new exam look like? Samples of exam questions from AP Exams will be viewed through the lens of cognitive research. Alternative physics challenges will be presented and the difficulties in grading these questions noted.

  6. Evolutionary period changes in the rapidly oscillating Ap stars

    NASA Technical Reports Server (NTRS)

    Heller, Clayton H.; Kawaler, Steven D.

    1988-01-01

    Preliminary computations of the asymptotic p-mode frequency spacings, and their time derivatives, are presented for a grid of evolutionary models of the rapidly oscillating Ap ('roAp') stars. It is shown how the frequency spacings depend on stellar mass, metallicity, and evolutionary stage. The frequency spacings observed in two of the roAp stars indicate that they either are main-sequence objects or have evolved off of the main sequence, depending on how the pulsation spectrum is interpreted. A way to remove this ambiguity is suggested: secular evolutionary changes in the pulsation frequencies may be measurable if the roAp stars have evolved off of the main sequence. In principle, this determination may be made for the roAp star HR 1217 with existing data.

  7. Top-up operation experience at APS.

    SciTech Connect

    Emery, L.

    1999-03-31

    The Advanced Photon Source (APS) is a 7-OeV, third-generation synchrotrons radiation source. To provide more stable beam for users, in September 1998 we began commissioning a new operating mode called ''top-up.'' In this mode, the beam current does not decay but is maintained at a high level using frequent injection, while photon shutters are open and photon beams are delivered to users. The hardware, software, and safety requirements for top-up will be reported. Safety issues related to injection with open photon shutters are covered in companion papers in this conference. Recent operational experience includes testing aspects of top-up injection and delivering beam to X-ray users for a few hours with fractional current stability of 10{sup {minus}3}. We expect to run several top-up operation shifts in Spring 1999. Issues of importance are orbit and emittance transients during the injection and scheduling of injection pulses for the convenience of users.

  8. High Pressure Reverse Flow APS Engine

    NASA Technical Reports Server (NTRS)

    Senneff, J. M.

    1972-01-01

    A design and test demonstration effort was undertaken to evaluate the concept of the reverse flow engine for the APS engine application. The 1500 lb (6672 N) thrust engine was designed to operate on gaseous hydrogen and gaseous oxygen propellants at a mixture ratio of 4 and to achieve the objective performance of 435 sec (4266 Nsec/kg) specific impulse. Superimposed durability requirements called for a million-cycle capability with 50 hours duration. The program was undertaken as a series of tasks including the initial preliminary design, design of critical test components and finally, the design and demonstration of an altitude engine which could be used interchangeably to examine operating parameters as well as to demonstrate the capability of the concept. The program results are reported with data to indicate that all of the program objectives were met or exceeded within the course of testing on the program. The analysis effort undertaken is also reported in detail and supplemented with test data in some cases where prior definitions could not be made. The results are contained of these analyses as well as the test results conducted throughout the course of the program. Finally, the test data and analytical results were combined to allow recommendations for a flight weight design. This preliminary design effort is also detailed.

  9. Notice to fruit growers and nurserymen relative to the naming and release of GulfSnow peach

    Technology Transfer Automated Retrieval System (TEKTRAN)

    GulfSnow peach is jointly released for grower trial by the U.S. Department of Agriculture, Agricultural Research Service (Byron, GA), Georgia Agricultural Experiment Station and Florida Agricultural Experiment Station. GulfSnow was previously tested as AP06-09W and originated from a cross of AP98-3...

  10. Predictive Validity Study of the APS Writing and Reading Tests [and] Validating Placement Rules for the APS Writing Test.

    ERIC Educational Resources Information Center

    College of the Canyons, Valencia, CA. Office of Institutional Development.

    California's College of the Canyons has used the College Board Assessment and Placement Services (APS) test to assess students' abilities in basic and college English since spring 1993. These two reports summarize data from a May 1994 study of the predictive validity of the APS writing and reading tests and a June 1994 effort to validate the cut…

  11. Development of Press-Coated, Floating-Pulsatile Drug Delivery of Lisinopril

    PubMed Central

    Jagdale, Swati C.; Suryawanshi, Vishnu M.; Pandya, Sudhir V.; Kuchekar, Bhanudas S.; Chabukswar, Aniruddha R.

    2014-01-01

    Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor, primarily used for the treatment of hypertension, congestive heart failure, and heart attack. It belongs to BCS class III having a half-life of 12 hrs and 25% bioavailability. The purpose of the present work was to develop a press-coated, floating-pulsatile drug delivery system. The core tablet was formulated using the super-disintegrants crosprovidone and croscarmellose sodium. A press-coated tablet (barrier layer) contained the polymer carrageenan, xanthan gum, HPMC K4M, and HPMC K15M. The buoyant layer was optimized with HPMC K100M, sodium bicarbonate, and citric acid. The tablets were evaluated for physical characteristics, floating lag time, swelling index, FTIR, DSC, and in vitro and in vivo behavior. The 5% superdisintgrant showed good results. The FTIR and DSC study predicted no chemical interactions between the drug and excipients. The formulation containing xanthan gum showed drug retaining abilities, but failed to float. The tablet containing HPMC K15M showed a high swelling index. The lag time for the tablet coated with 200 mg carrageenan was 3±0.1 hrs with 99.99±1.5% drug release; with 140 mg HPMC K4M, the lag time was 3±0.1 hrs with 99.71±1.2% drug release; and with 120 mg HPMC K15M, the lag time was 3±0.2 hrs with 99.98±1.7% drug release. The release mechanism of the tablet followed the Korsmeyer-Peppas equation and a first-order release pattern. Floating and lag time behavior have shown good in vitro and in vivo correlations. PMID:24959410

  12. Development of press-coated, floating-pulsatile drug delivery of lisinopril.

    PubMed

    Jagdale, Swati C; Suryawanshi, Vishnu M; Pandya, Sudhir V; Kuchekar, Bhanudas S; Chabukswar, Aniruddha R

    2014-06-01

    Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor, primarily used for the treatment of hypertension, congestive heart failure, and heart attack. It belongs to BCS class III having a half-life of 12 hrs and 25% bioavailability. The purpose of the present work was to develop a press-coated, floating-pulsatile drug delivery system. The core tablet was formulated using the super-disintegrants crosprovidone and croscarmellose sodium. A press-coated tablet (barrier layer) contained the polymer carrageenan, xanthan gum, HPMC K4M, and HPMC K15M. The buoyant layer was optimized with HPMC K100M, sodium bicarbonate, and citric acid. The tablets were evaluated for physical characteristics, floating lag time, swelling index, FTIR, DSC, and in vitro and in vivo behavior. The 5% superdisintgrant showed good results. The FTIR and DSC study predicted no chemical interactions between the drug and excipients. The formulation containing xanthan gum showed drug retaining abilities, but failed to float. The tablet containing HPMC K15M showed a high swelling index. The lag time for the tablet coated with 200 mg carrageenan was 3±0.1 hrs with 99.99±1.5% drug release; with 140 mg HPMC K4M, the lag time was 3±0.1 hrs with 99.71±1.2% drug release; and with 120 mg HPMC K15M, the lag time was 3±0.2 hrs with 99.98±1.7% drug release. The release mechanism of the tablet followed the Korsmeyer-Peppas equation and a first-order release pattern. Floating and lag time behavior have shown good in vitro and in vivo correlations. PMID:24959410

  13. 6. Interior, first floor front room. View of pressed metal ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Interior, first floor front room. View of pressed metal ceiling visible through opening in dropped ceiling. (Below the pressed metal ceiling are three wooden joists, two electrical wires and the edges of the dropped ceiling where a panel had been removed). - Ferree Building, 417 Ninth Street, Northwest, Washington, District of Columbia, DC

  14. New Realities for Scholarly Presses in Trying Economic Times

    ERIC Educational Resources Information Center

    Blakesley, David

    2014-01-01

    The author explains that Parlor Press is an independent publisher and distributor of scholarly and trade books in print and digital formats. It was founded in 2002 to address the need for an alternative scholarly, academic press attentive to emergent ideas and forms while maintaining the highest possible standards of quality, credibility, and…

  15. Westview Press: Small Is Beautiful--and Profitable.

    ERIC Educational Resources Information Center

    Evans, Nancy

    1979-01-01

    Westview Press in Boulder, Colorado, is a small independent press with an interest in scholarly publishing, especially manuscripts concerned with international and public policy. High speed and low cost are the advantages of its no-frills production method. A description of its operation and guidelines for authors are presented. (JMD)

  16. First Amendment Speech and Press Theory: Preferred Position Postulate Reexamined.

    ERIC Educational Resources Information Center

    Stonecipher, Harry W.

    If the United States Supreme Court is to exercise its historic role as guardian of the fundamental freedoms flowing from the speech and press clauses of the first amendment, it is imperative that those basic freedoms be placed in a preferred position. The preferred position doctrine provides adequate safeguards for both speech and press guarantees…

  17. 7. VIEW OF HYDRAULIC HAMMER STAMPING PRESS ON SIDE A ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. VIEW OF HYDRAULIC HAMMER STAMPING PRESS ON SIDE A OF BUILDING 883. THIS TYPE OF PRESS WAS USED FOR BOTH STAINLESS STEEL AND FOR DEPLETED URANIUM. (7/2/86) - Rocky Flats Plant, Uranium Rolling & Forming Operations, Southeast section of plant, southeast quadrant of intersection of Central Avenue & Eighth Street, Golden, Jefferson County, CO

  18. 29 CFR 1910.217 - Mechanical power presses.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 5 2011-07-01 2011-07-01 false Mechanical power presses. 1910.217 Section 1910.217 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OCCUPATIONAL SAFETY AND HEALTH STANDARDS Machinery and Machine Guarding § 1910.217 Mechanical power presses. (a) General requirements....

  19. Korean and Japanese Press: A Study in Crisis.

    ERIC Educational Resources Information Center

    Ruidl, Richard A.

    During a time of crisis, it is instructive to examine the national press of Japan and Korea, two economic allies that view each other with suspicion. The Japanese press is relatively free and liberal-oriented on the domestic scene but is closely aligned with big business and government with regard to international concerns. The South Korean…

  20. Criticism of the Press: Its Social, Psychological and Political Origins.

    ERIC Educational Resources Information Center

    Becker, Lee B.; And Others

    This study examines data from several national polls about press coverage during the Watergate scandal, in order to assess the origins of press criticism. The polls were conducted between 28 September and 6 October 1973, during June 1974, and in August 1974. The data suggest that political variables--particularly support of Nixon, party…

  1. 6. VIEW OF THE BRIQUETTING PRESS AND CHIP CLEANING HOOD. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. VIEW OF THE BRIQUETTING PRESS AND CHIP CLEANING HOOD. SCRAPS OF ENRICHED URANIUM FROM MACHINING OPERATIONS WERE CLEANED IN A SOLVENT BATH, THEN PRESSED INTO BRIQUETTS. THE BRIQUETTS WERE USED AS FEED MATERIAL FOR THE FOUNDRY. (4/4/66) - Rocky Flats Plant, General Manufacturing, Support, Records-Central Computing, Southern portion of Plant, Golden, Jefferson County, CO

  2. 9. DETAILED VIEW OF BRIQUETTING PRESS HOUSED IN A GLOVE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. DETAILED VIEW OF BRIQUETTING PRESS HOUSED IN A GLOVE BOX. THE PRESS FORMED SCRAP PLUTONIUM METAL FROM FOUNDRY AND FABRICATION PROCESSES INTO SMALL BRIQUETTES. THESE BRIQUETTES BECAME PART OF THE FEED MATERIALS FOR THE FOUNDRY. (5/6/59) - Rocky Flats Plant, Plutonium Fabrication, Central section of Plant, Golden, Jefferson County, CO

  3. 10. VIEW OF MODULE B, INSTALLATION OF A HYDRAULIC PRESS. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. VIEW OF MODULE B, INSTALLATION OF A HYDRAULIC PRESS. THE PRESS WILL EVENTUALLY BE CONNECTED TO A GLOVE BOX LINE. (9/29/69) - Rocky Flats Plant, Plutonium Manufacturing Facility, North-central section of Plant, just south of Building 776/777, Golden, Jefferson County, CO

  4. Migration and wear of hydroxyapatite-coated press-fit cups in revision hip arthroplasty: a radiostereometric study.

    PubMed

    Nivbrant, B; Kärrholm, J

    1997-12-01

    Screw-fixated and hydroxyapatite-coated press-fit cups were studied using radiostereometry in 29 revision and 14 primary arthroplasties. The acetabular defects in the revision cases varied from none to type 3 (wall defects) according to Gustilo-Pasternak. Morsellized allograft was used in 25 revisions. Nine of these cups rested on less than 50% living bone. After 2 years, the mean migration in the revised group reached 0.36, 0.21, and 0.49 mm in the horizontal, longitudinal, and anteroposterior (AP) directions. The mean rotations varied between 0.5 degrees and 0.7 degrees depending on direction. The primary implants displayed smaller mediolateral migration and AP tilt. The mean proximal wear rate for the whole group was 0.11 mm/y. A central gap on the postoperative AP view implied less migration. The size of the preoperative bone defects or amount of bone-graft used had no influence on the migration. Despite extensive use of morsellized allograft, this implant displayed the smallest migration so far reported in revision hip arthroplasty. PMID:9458256

  5. Comparison of ceramic waste forms produced by hot uniaxial pressing and by cold pressing and sintering

    SciTech Connect

    Oversby, V.M.; Vance, E.R.

    1994-09-01

    Synroc C waste form specimens prepared using the Australian-developed technology are uniaxially pressed in stainless steel bellows at 1200{degrees}C and 20MPa. This produces a material with high chemical and physical durability and with the radioactivity enclosed inside both the waste form and the bellows. An alternative method of producing the ceramic product is to use cold pressing of pellets followed by reactive sintering to provide densification and mineralization. Depending on the scale of waste form preparation required and on the activity level and nature of the waste streams, the cold press and sinter method may have advantages. To evaluate the effects of production method on waste form characteristics, especially resistance to dissolution or leaching of waste elements, we have prepared two simulated waste samples for evaluation. Both samples were prepared from liquid precursor materials (alkoxides, nitrates, and colloidal silica) and then doped with waste elements. The precursor material in each case corresponded to a basic phase assemblage of 60% zirconolite, 15% nepheline, 10% spinel, 10% perovskite, and 5% rutile. One sample was doped with 25% by weight of U; the other with 10% by weight each of U and Gd. Each sample was calcined at 750{degrees}C for 1 hr. in a 3.5% H{sub 2} in N{sub 2} atmosphere. Then one portion of each sample was hot pressed at temperatures ranging from 1120 to 1250{degrees}C and 20MPa pressure in steel bellows. A separate portion of each sample was formed into pellets, cold pressed, and sintered in various atmospheres at 1200{degrees}C to produce final products about 2/3 cm in diameter. Samples were then examined to determine density of the product, grain sizes of the phases, phase assemblage, and the location of the U and Gd in the final phases. Density data indicate that sintering gives good results provided that the samples are held at 200{degrees}C for long enough to allow trapped gases to escape.

  6. Modeling of planetesimal compaction by hot pressing

    NASA Astrophysics Data System (ADS)

    Neumann, W.; Breuer, D.; Spohn, T.

    2014-07-01

    Compaction of initially porous material prior to melting is an important process that has influenced the interior structure and the thermal evolution of planetesimals in their early history. On one hand, compaction decreases the porosity resulting in a reduction of the radius. On the other hand, the loss of porosity results in an increase of the thermal conductivity of the material and, thus, in a more efficient cooling. Porosity loss by hot pressing is the most efficient process of compaction in planetesimals and can be described by creep flow, which depends on temperature and stress. Hot pressing has been repeatedly modeled using a simplified approach, for which the porosity is gradually reduced in some fixed temperature interval between ~650 K and 700 K [see e.g. 1--3]. This approach neglects the dependence of compaction on stress. In the present study [see 4], we compare this ''parametrized'' method with a self-consistent calculation of porosity loss via a ''creep-related'' approach. We use our thermal evolution model from previous studies [5] to model compaction of an initially porous ordinary chondritic body and consider four basic packings of spherical dust grains (simple cubic, orthorhombic, rhombohedral, and body-centered cubic). Depending on the grain packing, we calculate the effective stress and the associated porosity change via the thermally activated creep flow. For comparison, compaction is also modeled by simply reducing the initial porosity linearly to zero between 650 and 700 K. Since we are interested in thermal metamorphism and not melting, we only consider bodies that experience a maximum temperature below the solidus temperature of the metal phase. For the creep related approach, the temperature interval in which compaction takes place depends strongly on the size of the planetesimal and is not fixed as assumed in the parametrized approach. Depending on the radius, the initial grain size, the activation energy, the initial porosity, and the

  7. Parallelization of Rocket Engine Simulator Software (PRESS)

    NASA Technical Reports Server (NTRS)

    Cezzar, Ruknet

    1997-01-01

    Parallelization of Rocket Engine System Software (PRESS) project is part of a collaborative effort with Southern University at Baton Rouge (SUBR), University of West Florida (UWF), and Jackson State University (JSU). The second-year funding, which supports two graduate students enrolled in our new Master's program in Computer Science at Hampton University and the principal investigator, have been obtained for the period from October 19, 1996 through October 18, 1997. The key part of the interim report was new directions for the second year funding. This came about from discussions during Rocket Engine Numeric Simulator (RENS) project meeting in Pensacola on January 17-18, 1997. At that time, a software agreement between Hampton University and NASA Lewis Research Center had already been concluded. That agreement concerns off-NASA-site experimentation with PUMPDES/TURBDES software. Before this agreement, during the first year of the project, another large-scale FORTRAN-based software, Two-Dimensional Kinetics (TDK), was being used for translation to an object-oriented language and parallelization experiments. However, that package proved to be too complex and lacking sufficient documentation for effective translation effort to the object-oriented C + + source code. The focus, this time with better documented and more manageable PUMPDES/TURBDES package, was still on translation to C + + with design improvements. At the RENS Meeting, however, the new impetus for the RENS projects in general, and PRESS in particular, has shifted in two important ways. One was closer alignment with the work on Numerical Propulsion System Simulator (NPSS) through cooperation and collaboration with LERC ACLU organization. The other was to see whether and how NASA's various rocket design software can be run over local and intra nets without any radical efforts for redesign and translation into object-oriented source code. There were also suggestions that the Fortran based code be

  8. Lifting shoeprints using gelatin lifters and a hydraulic press.

    PubMed

    Shor, Yaron; Tsach, Tsadok; Vinokurov, Asya; Glattstein, Baruch; Landau, Eliezer; Levin, Nadav

    2003-03-01

    A method for lifting two-dimensional dust footwear marks on rough or porous surfaces, such as cardboard or cloth, using a hydraulic press, was examined. It was found that exerting pressure on the lifter by the press usually improves the quality of the results. When the shoeprints were on rough or soft surfaces, the prints transferred to the gelatin lifters were better than those obtained by the conventional method. In other cases, using the press did not improve the results but was much simpler to apply. Based on the results of this study, the hydraulic press/gelatin lifter method (the "press method") is used at the authors' laboratory, depending on the surface from which the shoeprint is to be lifted. It is the authors' intention to apply the method to other surfaces after finding the optimal pressure for surfaces with loose fibers. PMID:12664996

  9. Speed-invariant, on-press color quality measurements

    SciTech Connect

    Simpson, M.L.; Bliss, R.F.; McMillan, D.E.; Nodine, R.N.; Goddard, J.S.

    1991-12-03

    Color measurement is an important aspect of quality control for graphic printing press operation. Normally, measurements of color quality are performed by sampling the product off-line, in which case feedback to press operators is not available in a timely manner. On-press measurement of color quality provides timely feedback to the press operators; however, maintaining the accuracy of the measurement in a dynamic setting is not trivial. In this paper, a colorimeter measurement system using commercially available equipment is described for making reliable, on-press color measurements. The system was demonstrated on a web test bed running loops of printed graphic images. Examples of commercially printed graphic material include product labels, packaging, stamps, and wall paper. Resulting color measurements were shown to be highly sensitive to variations in color-content while maintaining invariance to web speeds as high as 500 ft/min. 6 refs.

  10. Raising the acceptance of the AP2-line

    SciTech Connect

    Trbojevic, D.

    1989-04-05

    The 120 GeV Main Ring proton beam collides with the target at the end of the AP-1 line and creates antiprotons and other secondary particles. The AP-2 line transfers the negative particles from the target to the Debuncher. To provide a bigger antiproton stack size in the Accumulator, both the Debuncher as well as the AP-2 line acceptance have to be raised. This is a proposal for the improvement of the AP-2 line acceptance. The first part of the memo presents an acceptance examination of the existing AP-2 line by computer simulation, while the second presents a short proposal for aperture corrections. The computer program TURTLE was used to trace antiprotons through the AP-2 line without taking into account other negative charged particles. Betatron functions were obtained from the output of the SYNCH computer program. The SYNCH program was also used to check the dispersion match between the AP-2 line and the Debuncher. 3 refs., 6 figs., 5 tabs.

  11. EPICS Input/Output Controller (IOC) application developer`s guide. APS Release 3.12

    SciTech Connect

    Kraimer, M.R.

    1994-11-01

    This document describes the core software that resides in an Input/Output Controller (IOC), one of the major components of EPICS. The basic components are: (OPI) Operator Interface; this is a UNIX based workstation which can run various EPICS tools; (IOC) Input/Output Controller; this is a VME/VXI based chassis containing a Motorola 68xxx processor, various I/O modules, and VME modules that provide access to other I/O buses such as GPIB, (LAN), Local Area Network; and this is the communication network which allows the IOCs and OPIs to communicate. Epics provides a software component, Channel Access, which provides network transparent communication between a Channel Access client and an arbitrary number of Channel Access servers.

  12. STS-46 post flight press conference

    NASA Astrophysics Data System (ADS)

    1992-08-01

    At a post flight press conference, the flight crew of the STS-46 mission (Cmdr. Loren Shriver, Pilot Andrew Allen, Mission Specialists Claude Nicollier (European Space Agency (ESA)), Marsha Ivins (Flight Engineer), Jeff Hoffman (Payload Commander), Franklin Chang-Dias, and Payload Specialist Franco Malerba (Italian Space Agency (ISA))) discussed their roles in and presented video footage, slides and still photographs of the different aspects of their mission. The primary objectives of the mission were the deployment of ESA's European Retrievable Carrier (EURECA) satellite and the joint NASA/ISA deployment and testing of the Tethered Satellite System (TSS). Secondary objectives included the IMAX Camera, the Limited Duration Space Environment Candidate Materials Exposure (LDVE), and the Pituitary Growth Hormone Cell Function (PHCF) experiments. Video footage of the EURECA and TSS deployment procedures are shown. Earth views were extensive and included Javanese volcanoes, Amazon basin forest ground fires, southern Mexico, southern Bolivian volcanoes, south-west Sudan and the Sahara Desert, and Melville Island, Australia. Questions from reporters and journalists from Johnson Space Center and Kennedy Space Center were discussed.

  13. [Work disability in public press professions].

    PubMed

    Akermann, S

    2002-09-01

    In this study more than 1,000 cases of long-term disability among members of the press and media were evaluated. Mental disorders were the main cause of disability in almost every fourth case. In women psychiatric illnesses were even more important. The most common diagnosis was that of a depressive disorder which accounted for more than half of all psychiatric cases. The causes of disability of other insurance systems such as the German social security scheme and the pension and disability plan for the medical profession were compared. Mental illnesses are the leading cause of disability in white collar workers and orthopaedic illnesses, especially disorders of the vertebral column, are the leading cause in blue collar workers, as one might have expected. In females mental disorders are even more common than in men whereas men tend to have more cardiovascular problems than women. In this study also some interesting features regarding disability caused by various illnesses after long-term follow-up were found. This opens unknown perspectives allowing new assessment of diseases and eventually will enable the actuary to price medical diagnoses for disability insurance. PMID:12242775

  14. Hot isostatic press waste option study report

    SciTech Connect

    Russell, N.E.; Taylor, D.D.

    1998-02-01

    A Settlement Agreement between the Department of Energy and the State of Idaho mandates that all high-level radioactive waste now stored at the Idaho Chemical Processing Plant be treated so that it is ready to move out of Idaho for disposal by the target date of 2035. This study investigates the immobilization of all Idaho Chemical Processing Plant calcine, including calcined sodium bearing waste, via the process known as hot isostatic press, which produces compact solid waste forms by means of high temperature and pressure (1,050 C and 20,000 psi), as the treatment method for complying with the settlement agreement. The final waste product would be contained in stainless-steel canisters, the same type used at the Savannah River Site for vitrified waste, and stored at the Idaho National Engineering and Environmental Laboratory until a national geological repository becomes available for its disposal. The waste processing period is from 2013 through 2032, and disposal at the High Level Waste repository will probably begin sometime after 2065.

  15. STS-114: Discovery Post MMT Press Conference

    NASA Technical Reports Server (NTRS)

    2005-01-01

    Bruce Buckingham of NASA Public Affairs hosted this press conference. Wayne Hill, Space Shuttle Deputy Program Manager; John Muratore, Shuttle Systems and Integration Manager; Mike Wetmore, Director for Shuttle Processing were present. Wayne started with a video from Shuttle Logistics Depot showing details of a point sensor box commonly named the black box. Work with the trouble shooting continues on a day to day basis, no definite launching date is set. John reports that they are in a mission support mode all over the country until the sensor problem is solved. Mike reports his team will complete scrub and securing tasks through the next day, restore the facility to its normal mode, and will start to a four day process of getting back to launch once trouble shooting is completed. Tanking test, thermal environment, problem identification, engine cut-off sensor problems, sensors, risk, design reviews, test and analysis, correlation of the problem with Columbia, are some of the topics covered with the News media.

  16. [Gender and health in the daily press].

    PubMed

    Revuelta, Gemma; Alonso, Inma; Tomás, Sonia; Guerrero, Marcela; Rohlfs, Izabella

    2004-05-01

    To have a better understanding on the role of the press in the communication of gender and health issues, the content of the five most spread newspapers in Spain was studied (El País, ABC, El Mundo, La Vanguardia and El Periódico de Catalunya) for five years (1997-2001) and the electronic version of The New York Times of the period 1990-1999. An unequal distribution was observed in the responsibility as for the information related to three aspects: positions of responsibility in the newspapers (out of 71 main posts, 67 were men and 4 women); the authors of the articles on health issues (61.2% men and 38,8% women, among the articles that include the author) and the mentioned information sources (81.43% men and 17.77% women). Among the 120 health issues that were covered during the period of the study, only 20 explicitly mentioned a woman (16.67%). Those subjects that included more frequently explicit references were: ablation, iatrogenics, sterilization, sexual and reproductive health, incontinence, beauty and domestic violence. The analysis of the approach to these subjects helped to identify the stereotypes of gender inequality, in the language as well as in the approach. PMID:15171880

  17. Development of Emergency Response Guidelines (ERGs) for AP1000

    SciTech Connect

    Yuichi Hayashi; Saiu, Gianfranco; Wright, Richard F.

    2006-07-01

    The AP1000 is two-loop 1100 MWe advanced pressurized water reactor (PWR) that uses passive safety features to enhance plant safety and to provide significant and measurable improvements in plant simplification, reliability, investment protection and plant costs. The AP1000 uses proven technology, which builds on over 30 years of operating PWR experience. The AP1000 final design certification has been approved by the NRC in December, 2005. The Emergency Response Guidelines (ERGs) have been developed for the AP1000. The generic ERGs for the low pressure reference PWR plant were used as the basic documents to develop the AP1000 ERGs. The AP1000 design differences from the reference plant were reviewed and reflected in the process of developing operational steps in each ERG. The AP1000 used PRA in both design and licensing. The provisions of the AP1000 PRA were also reviewed and incorporated into the ERGs Although the AP1000 design does not require operator actions for the first 72 hours after accidents, the operator actions with both safety-related and non-safety-related equipment have an important role to mitigate the consequence of accidents. In the event of a LOCA, the AP1000 safety-related passive core cooling system (PXS) provides sources of core makeup water along with an automatic depressurization system (ADS) consisting of several sets of redundant flow paths which are sequentially opened in stages to reduce the reactor coolant system (RCS) pressure in a controlled manner. The final stage of this system, ADS-4, consists of four large valves that open off the hot legs, reducing the pressure to allow gravity injection from the in-containment refueling water storage tank (IRWST) and eventually the containment sump recirculation. The AP1000 has non-safety-related normal residual heat removal system (RNS) pumps which can be used to provide low pressure pumped injection of cask loading pit and/or IRWST water and recirculation of containment water. These pumps are

  18. A new gap separation mechanism for APS insertion devices.

    SciTech Connect

    Trakhtenberg, E. M.; Tcheskidov, V.; Den Hartog, P. K.; Deriy, B.; Erdmann, M.; Makarov, O.; Moog, E. R.

    1999-10-25

    A new gap separation mechanism for use with the standard Advanced Photon Source (APS) 3.3-cm-period undulator magnetic structures has been designed and built and the first system has been installed in the APS storage ring. The system allows a minimum magnetic gap of 10 mm for use with the APS 8-mm insertion device vacuum chambers. The mechanism is a bolted steel frame structure with a simple 4-motor mechanical drive train. The control system uses servomotors with incremental rotary encoders and virtual absolute linear encoders.

  19. AP600 design certification thermal hydraulics testing and analysis

    SciTech Connect

    Hochreiter, L.E.; Piplica, E.J.

    1995-09-01

    Westinghouse Electric Corporation, in conjunction with the Department of Energy and the Electric Power Research Institute, have been developing an advanced light water reactor design; the AP600. The AP600 is a 1940 Mwt, 600Mwe unit which is similar to a Westinghouse two-loop Pressurized Water Reactor. The accumulated knowledge on reactor design to reduce the capital costs, construction time, and the operational and maintenance cost of the unit once it begins to generate electrical power. The AP600 design goal is to maintain an overall cost advantage over fossil generated electrical power.

  20. The Watchdog in Nineteenth Century Libel Law: A Common Law Concept of Freedom of the Press.

    ERIC Educational Resources Information Center

    Gleason, Timothy W.

    In press law, the individual right of freedom of the press frequently is linked to a public interest or "watchdog" concept of freedom of the press. This concept suggests that the basis for the constitutional protection of press freedom is the role of the press as an institution serving a collective good, as opposed to the traditional view of…

  1. Mapping of the spontaneous deletion in the Ap3d1 gene of mocha mice: fast and reliable genotyping

    PubMed Central

    Drasbek, Kim Ryun; Holm, Mai Marie; Delenclos, Marion; Jensen, Kimmo

    2008-01-01

    Background The mocha mouse carries a spontaneous deletion in the Ap3d1 gene, encoding the delta 1 subunit of the adaptor related protein complex 3, (Ap3d1), and subsequently lack the expression of functional AP-3. This leads to a deficiency in vesicle transport and storage, which affects neurotransmitter vesicle turnover and release in the central nervous system. Since the genomic sequence of the Ap3d1 gene of mocha mouse is not known, precise mapping of the deletion as well as reliable genotyping protocols are lacking. Findings We sequenced the Ap3d1 gene (HGNC GeneID: 8943) around the deletion site in the mocha mouse and revealed a 10639 bp deletion covering exon 2 to 6. Subsequently, new PCR primers were designed yielding a reliable genotyping protocol of both newborn and adult tissue. To examine the genotypes further, hippocampal neurons were cultured from mocha and control mice. Patch-clamp recordings showed that mocha neurons had a higher input resistance, and that autaptic EPSC in mocha cultures depressed faster and stronger as compared with control cultures. Conclusion Our study reports the sequence of the deleted part of the Ap3d1 gene in mocha mice, as well as a reliable PCR-based genotyping protocol. We cultured hippocampal neurons from control and mocha mice, and found a difference in input resistance of the neurons, and in the synaptic short-term plasticity of glutamatergic autapses showing a larger synaptic depression than controls. The described procedures may be useful for the future utilization of the mocha mouse as a model of defective vesicle biogenesis. Importantly, as genotyping by eye color is complicated in newborn mice, the designed protocol is so fast and reliable that newborn mice could rapidly be genotyped and hippocampal neurons dissociated and cultured, which is normally best done at P0-P2. PMID:19032734

  2. Manipulation of stretch-induced atriopeptin prohormone release and processing in the perfused rat heart.

    PubMed Central

    Ito, T; Toki, Y; Siegel, N; Gierse, J K; Needleman, P

    1988-01-01

    Atriopeptin (AP) is stored as the prohormone AP-126 [atrial natriuretic factor-(1-26)] in atrial granules. Cultured atrial myocytes synthesize and release only prohormone into the medium. HPLC analysis of the coronary venous effluent of media from perfused rat hearts subjected to right atrial stretch indicated the presence of the C-terminal mature hormone AP-28 [atrial natriuretic factor-(99-126)] and little or no prohormone. Absence of calcium from the perfusion medium increased total AP release and surprisingly blocked the proteolytic cleavage of the prohormone. Similarly, addition of the proteolytic inhibitor aprotinin to the perfusion medium suppressed the processing of the endogenous AP-126 released by atrial stretch. Aprotinin would be restricted to the extracellular space, which is therefore implicated as the site of prohormone processing. This suggestion was validated by the demonstration that the perfused rat heart could readily cleave exogenous prohormone to mature hormone, a process blocked by aprotinin. Hypothetically, the stimulus-release-processing event initiated by atrial stretch may require the concerted action of the synthetic cell (i.e., atrial myocyte) and a processing cell or site (e.g., the adjacent atrial mesenchymal cell) for the production of the mature AP-28, which is the circulating molecular form of this endocrine system. Images PMID:2973064

  3. Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes

    PubMed Central

    Sitaram, Anand; Dennis, Megan K.; Chaudhuri, Rittik; De Jesus-Rojas, Wilfredo; Tenza, Danièle; Setty, Subba Rao Gangi; Wood, Christopher S.; Sviderskaya, Elena V.; Bennett, Dorothy C.; Raposo, Graça; Bonifacino, Juan S.; Marks, Michael S.

    2012-01-01

    Cell types that generate unique lysosome-related organelles (LROs), such as melanosomes in melanocytes, populate nascent LROs with cargoes that are diverted from endosomes. Cargo sorting toward melanosomes correlates with binding via cytoplasmically exposed sorting signals to either heterotetrameric adaptor AP-1 or AP-3. Some cargoes bind both adaptors, but the relative contribution of each adaptor to cargo recognition and their functional interactions with other effectors during transport to melanosomes are not clear. Here we exploit targeted mutagenesis of the acidic dileucine–based sorting signal in the pigment cell–specific protein OCA2 to dissect the relative roles of AP-1 and AP-3 in transport to melanosomes. We show that binding to AP-1 or AP-3 depends on the primary sequence of the signal and not its position within the cytoplasmic domain. Mutants that preferentially bound either AP-1 or AP-3 each trafficked toward melanosomes and functionally complemented OCA2 deficiency, but AP-3 binding was necessary for steady-state melanosome localization. Unlike tyrosinase, which also engages AP-3 for optimal melanosomal delivery, both AP-1– and AP-3–favoring OCA2 variants required BLOC-1 for melanosomal transport. These data provide evidence for distinct roles of AP-1 and AP-3 in OCA2 transport to melanosomes and indicate that BLOC-1 can cooperate with either adaptor during cargo sorting to LROs. PMID:22718909

  4. Early Telegraphic News Dispatches: Forerunner of the AP

    ERIC Educational Resources Information Center

    Schwarzlose, Richard A.

    1974-01-01

    While the Associated Press's origins remain obscure, a "news broker" system operated in New York City in 1846 and news dispatches occupied telegraph lines almost as soon as the lines were opened. (RB)

  5. Pressing effect in polymer solar cells with bulk heterojunction nanolayers.

    PubMed

    Park, Jiho; Nam, Sungho; Kim, Hwajeong; Kim, Youngkyoo

    2011-01-01

    We report the effect of pressing light-absorbing layers on the performance of polymer solar cells. The light-absorbing active layer was prepared on the transparent conducting oxide coated substrates from solutions that contain a mixture of regioregular poly(3-hexylthiophene) and soluble fullerene molecules. The active layers were pressed using a home-built micro-press system by controlling temperature and pressure, followed by the top electrode deposition. The surface of the active layers pressed was examined using atomic force microscope, while the photovoltaic characteristics of devices were measured under simulated solar light illumination (air mass 1.5 G, 100 mW/cm2). Results showed that the dark current of devices was noticeably increased by pressing the active layer without respect to the pressing temperature. The highest power conversion efficiency was achieved for the device with the active layer pressed under 10 kgf at 70 degrees C. The result was explained in terms of surface morphology and thermophysical effect. PMID:21446447

  6. QCD on the Massively Parallel Computer AP1000

    NASA Astrophysics Data System (ADS)

    Akemi, K.; Fujisaki, M.; Okuda, M.; Tago, Y.; Hashimoto, T.; Hioki, S.; Miyamura, O.; Takaishi, T.; Nakamura, A.; de Forcrand, Ph.; Hege, C.; Stamatescu, I. O.

    We present the QCD-TARO program of calculations which uses the parallel computer AP1000 of Fujitsu. We discuss the results on scaling, correlation times and hadronic spectrum, some aspects of the implementation and the future prospects.

  7. Engaging Cuban Physicists Through the APS/CPS Partnership

    NASA Astrophysics Data System (ADS)

    Lerch, Irving A.; Lerch, Irving A.

    In his reflections on Cuban physics, Marcelo Alonso urges APS to take steps to promote interactions between Cuban and US physicists. As an introduction to Marcello's essay, this note will summarize past and current activities.

  8. An improved model for the combustion of AP composite propellants

    NASA Technical Reports Server (NTRS)

    Cohen, N. S.; Strand, L. D.

    1981-01-01

    This paper presents several improvements to the BDP model of steady-state burning of AP composite solid propellants. The Price-Boggs-Derr model of AP monopropellant burning is incorporated to represent the AP. A separate energy equation is written for the binder to permit a different surface temperature from the AP; this includes an analysis of the sharing of primary diffusion flame energy, and correction of a BDP model inconsistency in treating the binder regression rate. A method for assembling component contributions to calculate the burning rates of multimodal propellants is also presented. Results are shown in the form of representative burning rate curves, comparisons with data, and calculated internal details of interest. Ideas for future work are discussed in an Appendix.

  9. A hot-spare injector for the APS linac.

    SciTech Connect

    Lewellen, J. W.

    1999-04-13

    Last year a second-generation SSRL-type thermionic cathode rf gun was installed in the Advanced Photon Source (APS) linac. This gun (referred to as ''gun2'') has been successfully commissioned and now serves as the main injector for the APS linac, essentially replacing the Koontz-type DC gun. To help ensure injector availability, particularly with the advent of top-up mode operation at the APS, a second thermionic-cathode rf gun will be installed in the APS linac to act as a hot-spare beam source. The hot-spare installation includes several unique design features, including a deep-orbit Panofsky-style alpha magnet. Details of the hot-spare beamline design and projected performance are presented, along with some plans for future performance upgrades.

  10. Zinc coated sheet steel for press hardening

    NASA Astrophysics Data System (ADS)

    Ghanbari, Zahra N.

    Galvanized steels are of interest to enhance corrosion resistance of press-hardened steels, but concerns related to liquid metal embrittlement have been raised. The objective of this study was to assess the soak time and temperature conditions relevant to the hot-stamping process during which Zn penetration did or did not occur in galvanized 22MnB5 press-hardening steel. A GleebleRTM 3500 was used to heat treat samples using hold times and temperatures similar to those used in industrial hot-stamping. Deformation at both elevated temperature and room temperature were conducted to assess the coating and substrate behavior related to forming (at high temperature) and service (at room temperature). The extent of alloying between the coating and substrate was assessed on undeformed samples heat treated under similar conditions to the deformed samples. The coating transitioned from an α + Gamma1 composition to an α (bcc Fe-Zn) phase with increased soak time. This transition likely corresponded to a decrease in availability of Zn-rich liquid in the coating during elevated temperature deformation. Penetration of Zn into the substrate sheet in the undeformed condition was not observed for any of the processing conditions examined. The number and depth of cracks in the coating and substrate steel was also measured in the hot-ductility samples. The number of cracks appeared to increase, while the depth of cracks appeared to decrease, with increasing soak time and increasing soak temperature. The crack depth appeared to be minimized in the sample soaked at the highest soak temperature (900 °C) for intermediate and extended soak times (300 s or 600 s). Zn penetration into the substrate steel was observed in the hot-ductility samples soaked at each hold temperature for the shortest soak time (10 s) before being deformed at elevated temperature. Reduction of area and elongation measurements showed that the coated sample soaked at the highest temperature and longest soak time

  11. A Key Telegram and a Key Press Release on the Recognition of the State of Israel

    ERIC Educational Resources Information Center

    Byers, CeCe; Alexander, Mary

    1978-01-01

    Reviews the course of events leading to the founding of Israel in 1947. Presents primary source materials, activities, and discussion questions to help students analyze reasons for the Arab-Israeli conflict. (Author/DB)

  12. Learning the Genre of the Press Release: Developmental Processes in Adult Writers.

    ERIC Educational Resources Information Center

    Beaufort, Anne

    During a year-long ethnography in a workplace setting (a non-profit job and literacy training agency), a study examined how managers learned new genres required in their jobs. There were 2 research questions: (1) what are the specific aspects of a genre to be mastered for effective written communication? and (2) what is the developmental process…

  13. Divisions Iv-V / Working Group ap & Related Stars

    NASA Astrophysics Data System (ADS)

    Mathys, Gautier; Cunha, Margarida; Dworetsky, Michael; Kochukhov, Oleg; Kupka, Friedrich; LeBlanc, Francis; Monier, Richard; Paunzen, Ernst; Pintado, Olga; Piskunov, Nikolai; Ziznovsky, Jozef

    2012-04-01

    The purpose of the Working Group on Ap and Related Stars (ApWG) is to promote and facilitate research about stars in the spectral type range from B to early F that exhibit surface chemical peculiarities and related phenomena. This is a very active field of research, in which a wide variety of new developments have taken place since 2009, as illustrated by the following selected highlights.

  14. Fluoride release and antibacterial activity of selected dental materials.

    PubMed

    Marczuk-Kolada, Grazyna; Jakoniuk, Piotr; Mystkowska, Joanna; Łuczaj-Cepowicz, Elzbieta; Waszkiel, Danuta; Dabrowski, Jan Ryszard; Leszczyńska, Katarzyna

    2006-01-01

    The aim of the study was to assess the fluoride ion release and antibacterial activities of the glassionomer cement Fuji IX and the compomer (composite modified polyacid) Dyract AP. Fluoride ion release was measured using direct potentiometry with an Orion fluoride ion selective electrode. The measurement was carried out after 1, 4, 7, 14, 30, and 60 days of storage in phosphate buffer at pH 6.8. The antibacterial activity of the materials was evaluated against the bacteria Streptococcus mutans ATCC 35668, Streptococcus salivarius ATCC 13419, Streptococcus sanguis ATCC 10556, and Lactobacillus casei subsp. casei ATCC 393. The agar diffusion test was applied. The material specimens were assessed twice: after setting and seven days later. Zones of bacterial growth inhibition were measured in millimeters after 24 hours. The results of the study showed that both materials released ion fluoride, with a higher emission of Fuji IX than Dyract AP. The highest level of emission was observed on the seventh day of the study in both materials. After 24 hours of bonding there was inhibition of bacterial growth by Fuji IX, whereas Dyract AP did not show similar activity. On the eighth day after polymerization, Dyract AP was significantly more active towards Streptococcus sanguis and salivarius. PMID:18493226

  15. 57. ORIGINAL TILE PRESS AND EXPERIMENTAL DENTAL KILN, SECOND FLOOR, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    57. ORIGINAL TILE PRESS AND EXPERIMENTAL DENTAL KILN, SECOND FLOOR, NORTH WING, HENRY MERCER USED THE KILN FOR HIS EARLIEST GLAZE TESTS. THE PRESS WAS DESIGNED TO BE USED WITH METAL CASED MOLDS. SINCE ONLY THE EARLIEST TILE DESIGNS ARE IN METAL CASES. THIS TECHNIQUE WAS PROBABLY DISCONTINUED. THIS PRESS WAS, THEREFORE, PROBABLY NOT USED EXTENSIVELY AT THIS SITE. THE UPPER PART OF GLAZE KILN No. 2 IS AT THE LEFT REAR. - Moravian Pottery & Tile Works, Southwest side of State Route 313 (Swamp Road), Northwest of East Court Street, Doylestown, Bucks County, PA

  16. The (Very) Slow Rotation of Magnetic Ap Stars

    NASA Astrophysics Data System (ADS)

    Mathys, Gautier

    2015-08-01

    To this date, 34 magnetic Ap stars that have periods of variation longer than 30 days are known. They represent a considerable fraction of the total number of Ap stars whose period has been reliably determined. All the available evidence unambiguously indicates that the observed variations of those long-period Ap stars result from the changing aspect of their visible hemisphere as they rotate, thus that the oblique rotator model is applicable throughout the whole range of periods of variation of the Ap stars. We show that the periods of the most slowly rotating Ap stars must be of the order of 300 years, and that some may even be longer, possibly up to 1000 years. The 5 to 6 orders of magnitude spanned by the rotation periods of the Ap stars present a major challenge for the understanding of their origin and their evolution. To guide the theo- retical developments, observational hints may be found in possible differences between the magnetic properties of stars that have rotation periods in different ranges. Such differences are starting to emerge from the existing data. To increase their significance level, study of the longest-period stars must be continued over their full rotation cycle. Failure to secure observations now may leave critical data missing for several decades, or even centuries.

  17. Thermal Decomposition Characteristics of Orthorhombic Ammonium Perchlorate (o-AP)

    SciTech Connect

    Behrens, R.; Minier, L.

    1999-03-01

    Preliminary STMBMS and SEM results of the thermal decomposition of AP in the orthorhombic phase are presented. The overall decomposition is shown to be complex and controlled by both physical and chemical processes. The data show that the physical and chemical processes can be probed and characterized utilizing SEM and STMBMS. The overall decomposition is characterized by three distinguishing features: an induction period, and accelerator period and a deceleratory period. The major decomposition event occurs in the subsurface of the AP particles and propagates towards the center of the particle with time. The amount of total decomposition is dependent upon particle size and increases from 23% for {approximately}50{micro}m-diameter AP to 33% for {approximately}200{micro}m-diameter AP. A conceptual model of the physical processes is presented. Insight into the chemical processes is provided by the gas formation rates that are measured for the gaseous products. To our knowledge, this is the first presentation of data showing that the chemical and physical decomposition processes can be identified from one another, probed and characterized at the level that is required to better understand the thermal decomposition behavior of AP. Future work is planned with the goal of obtaining data that can be used to develop a mathematical description for the thermal decomposition of o-AP.

  18. VIEW WEST, 1ST FLOOR, EAST ROOM, HYDRAULIC COTTON PRESS, DETAIL, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW WEST, 1ST FLOOR, EAST ROOM, HYDRAULIC COTTON PRESS, DETAIL, CONTINENTAL GIN COMPANY HYDRAULIC TANK - Magnolia Plantation, Cotton Gins & Presses, LA Route 119, Natchitoches, Natchitoches Parish, LA

  19. Renovation of the hot press in the Plutonium Experimental Facility

    SciTech Connect

    Congdon, J.W.; Nelson, G.H.

    1990-03-05

    The Plutonium Experimental Facility (PEF) will be used to develop a new fuel pellet fabrication process and to evaluate equipment upgrades. The facility was used from 1978 until 1982 to optimize the parameters for fuel pellet production using a process which was developed at Los Alamos National Laboratory. The PEF was shutdown and essentially abandoned until mid-1987 when the facility renovations were initiated by the Actinide Technology Section (ATS) of SRL. A major portion of the renovation work was related to the restart of the hot press system. This report describes the renovations and modifications which were required to restart the PEF hot press. The primary purpose of documenting this work is to help provide a basis for Separations to determine the best method of renovating the hot press in the Plutonium Fuel Fabrication (PuFF) facility. This report also includes several SRL recommendations concerning the renovation and modification of the PuFF hot press. 4 refs.

  20. 41. Detail of punch press on left and large metal ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    41. Detail of punch press on left and large metal plate shear, Boiler Shop, located in north end of Machine Shop Building. - Thames Tow Boat Company, Foot of Farnsworth Street, New London, New London County, CT

  1. Rugged pressed disk electrode has low contact potential

    NASA Technical Reports Server (NTRS)

    Day, J. L.; Mosier, B.

    1965-01-01

    Pressed-disk electrode with low contact potential monitors physiological processes. It consists of silver and silver chloride combined with bentonitic clay. The clay affords a surface that permits use over extended periods without contact deterioration.

  2. VIEW OF INTERIOR SPACE WITH HUFFORD BULLDOZIER FORMING PRESS IN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF INTERIOR SPACE WITH HUFFORD BULLDOZIER FORMING PRESS IN FOREGROUND, FACING NORTHWEST. - Douglas Aircraft Company Long Beach Plant, Aircraft Parts Shipping & Receiving Building, 3855 Lakewood Boulevard, Long Beach, Los Angeles County, CA

  3. VIEW OF INTERIOR SPACE WITH SQUARE SHAPE STRETCH PRESS CONTAINMENT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF INTERIOR SPACE WITH SQUARE SHAPE STRETCH PRESS CONTAINMENT PITS CENTER, FACING NORTH. - Douglas Aircraft Company Long Beach Plant, Aircraft Parts Shipping & Receiving Building, 3855 Lakewood Boulevard, Long Beach, Los Angeles County, CA

  4. VIEW OF INTERIOR SPACE WITH RECTANGULAR SHAPE STRETCH PRESS CONTAINMENT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF INTERIOR SPACE WITH RECTANGULAR SHAPE STRETCH PRESS CONTAINMENT PIT IN BACKGROUND, FACING NORTH. - Douglas Aircraft Company Long Beach Plant, Aircraft Parts Shipping & Receiving Building, 3855 Lakewood Boulevard, Long Beach, Los Angeles County, CA

  5. 5. FOURTH FLOOR, HOTEL SOAP LINES TO NORTHWEST: PRESS (LEFT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. FOURTH FLOOR, HOTEL SOAP LINES TO NORTHWEST: PRESS (LEFT CENTER), MANUAL CUTTERS (CENTER, RIGHT CENTER) - Colgate & Company Jersey City Plant, Building No. B-15, 90-96 Greene Street, Jersey City, Hudson County, NJ

  6. 8. Second floor front apartment showing ornately painted pressed metal ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Second floor front apartment showing ornately painted pressed metal ceiling, as well as modern partitions and wall treatments. View looking north. - Franklin Grocery Company Building, 1 South Main Street, Franklin, Merrimack County, NH

  7. 13. RADIAL DRILL, ENGINE LATHE, DRILL PRESS, AND GRINDER (L ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. RADIAL DRILL, ENGINE LATHE, DRILL PRESS, AND GRINDER (L TO R)-LOOKING SOUTHEAST. - W. A. Young & Sons Foundry & Machine Shop, On Water Street along Monongahela River, Rices Landing, Greene County, PA

  8. INTERIOR VIEW WITH CARLTON RADIAL ARM DRILL PRESS (THE CARLTON ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    INTERIOR VIEW WITH CARLTON RADIAL ARM DRILL PRESS (THE CARLTON MACHINE TOOL CO., CINCINNATI, OHIO) WITH MACHINE OPERATOR, EDDIE BURTTRAM. - O'Neal Steel, Incorporated, Fabrication Shop, 744 Forty-first Avenue North, Birmingham, Jefferson County, AL

  9. 20. VIEW OF WATSON STILHMAN DISMOUNTING WHEEL PRESS. 600 tons. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. VIEW OF WATSON STILHMAN DISMOUNTING WHEEL PRESS. 600 tons. Gary Stich, operator. - Juniata Shops, Erecting Shop & Machine Shop, East of Fourth Avenue, between Fourth & Fifth Streets, Altoona, Blair County, PA

  10. Study of pressing machine pressure relief characteristics based on AMESim

    NASA Astrophysics Data System (ADS)

    Wang, Chuanli; Zhang, Hui; Yu, Caofeng; Wu, Xiaolei

    2016-01-01

    When a working cylinder of the pressing machine working cylinder was stuck and underwent retracted conversion, pressure shock was high in working cylinder cavity and flow pulsation was distinct in the pipeline due to the high working pressure and frequent retracted transformation of the working cylinder, which not only shortened the service life of the pressing machine, but also exerted serious impacts on the machining precision and quality, especially after the pressing machine applied loads and high-pressure oil in work rod end cavity of working cylinder needed to be relieved in a short time. In order to research and analyze the better pressure relief characteristics of the two types of pressure relief circuits of the pressing machine, the paper established models, carried out simulation and analysis and then made contrastive analysis of the working cylinder rod velocity, rod acceleration and port pressure pulsation according to the simulation results.

  11. AUTOMOTIVE REPAIR SHOP, DETAIL OF FABRICATING PRESS IN EAST END ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    AUTOMOTIVE REPAIR SHOP, DETAIL OF FABRICATING PRESS IN EAST END OF MAIN WING, WITH SCALE. - Cedar City Automotive Repair Shop, Automotive Repair Shop, 820 North Main Street, Cedar City, Iron County, UT

  12. VIEW OF THE INSTALLATION OF AN EXTRUSION PRESS IN THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF THE INSTALLATION OF AN EXTRUSION PRESS IN THE HIGH BAY AREA OF BUILDING 865. THE EXTRUSION PRESS WAS USED TO PRODUCE CYLINDRICAL BARS, HOLLOW TUBES, AND SHAPES WITH IRREGULAR CROSS-SECTIONS BY FORCING PREHEATED METAL THROUGH A DIE ORIFICE UNDER HIGH PRESSURE. (5/22/70) - Rocky Flats Plant, Metal Research & Development Laboratory, South of Central Avenue at south end of terminus of Ninth Avenue, Golden, Jefferson County, CO

  13. Gemini 10 prime crew during post flight press conference

    NASA Technical Reports Server (NTRS)

    1966-01-01

    At podium during Gemini 10 press conference are (l-r) Dr. Robert C. Seamans, Astronauts John Young and Michael Collins and Dr. Robert R. Gilruth (39895); Wide angle view of the Manned Spacecraft Center (MSC) News Center during the Gemini 10 prime crew post flight press conference (38786); Astronaut Young draws diagram on chalk board of tethered extravehicular activity accomplished during Gemini 10 flight (39897).

  14. Low-loss binder for hot pressing boron nitride

    DOEpatents

    Maya, Leon

    1991-01-01

    Borazine derivatives used as low-loss binders and precursors for making ceramic boron nitride structures. The derivative forms the same composition as the boron nitride starting material, thereby filling the voids with the same boron nitride material upon forming and hot pressing. The derivatives have a further advantage of being low in carbon thus resulting in less volatile byproduct that can result in bubble formation during pressing.

  15. Grain refinement of aluminum using equal-channel angular pressing

    SciTech Connect

    Horita, Z.; Furukawa, M.; Nemoto, M.; Langdon, T.G.

    2000-07-01

    Using the technique of equal-channel angular (ECA) pressing, it is possible to reduce the grain size of polycrystalline materials to the submicrometer level. Thus, this processing technique has the potential for producing materials which may exhibit superplasticity. This paper describes various factors affecting the development and evolution of the microstructure produced by ECA pressing. Optimization of such factors is then presented for the advent of superplasticity.

  16. Bending strength studies on hot-pressed silicon carbide

    NASA Technical Reports Server (NTRS)

    Kriegesmann, J.

    1984-01-01

    The 4-point bending strength of 4 grades of hot-pressed SiC was determined at different temperatures. With a transgranular mode of fracture the values for bending strength are retained up to high temperatures. For intergranular fracture the decrease of strength is governed by subcritical crack growth. The intergranular fracture is caused by a high content of silicate glassy phase at the grain boundaries of hot-pressed SiC.

  17. Binderless briquetting of coals and biomass in roll press

    SciTech Connect

    Komarek, R.K.

    1996-12-31

    An analysis of the stresses in compacted materials was employed to investigate methods which can improve briquettability of coal and biomass in roll press. The special roll face design, four roll press, as well as special hot briquetting installation were tested. Experimental results are given for several different briquetted materials. In the last section of the paper, the advantages of this process as well as possibilities for commercial application are discussed.

  18. Dosage form design and in vitro/in vivo evaluation of cevimeline extended-release tablet formulations.

    PubMed

    Tajiri, Shinichiro; Kanamaru, Taro; Kamada, Makoto; Makoto, Kamada; Konno, Tsutomu; Nakagami, Hiroaki

    2010-01-01

    The objective of the present work is to develop an extended-release dosage form of cevimeline. Two types of extended-release tablets (simple matrix tablets and press-coated tablets) were prepared and their potential as extended-release dosage forms were assessed. Simple matrix tablets have a large amount of hydroxypropylcellulose as a rate-controlling polymer and the matrix is homogeneous throughout the tablet. The press-coated tablets consisted of a matrix core tablet, which was completely surrounded by an outer shell containing a large amount of hydroxypropylcellulose. The simple matrix tablets could not sustain the release of cevimeline effectively. In contrast, the press-coated tablets showed a slower dissolution rate compared with simple matrix tablets and the release curve was nearly linear. The dissolution of cevimeline from the press-coated tablets was not markedly affected by the pH of the dissolution medium or by a paddle rotating speed over the range of 50-200 rpm. Furthermore, cevimeline was constantly released from the press-coated tablets in the gastrointestinal tract and the steady-state plasma drug levels were maintained in beagle dogs. These results suggested that the designed PC tablets have a potential for extended-release dosage forms. PMID:19747964

  19. AP@home: The Artificial Pancreas Is Now at Home.

    PubMed

    Heinemann, Lutz; Benesch, Carsten; DeVries, J Hans

    2016-07-01

    In the past years the development of an artificial pancreas (AP) has made great progress and many activities are ongoing in this area of research. The major step forward made in the last years was moving the evaluation of AP systems from highly controlled experimental conditions to daily life conditions at the home of patients with diabetes; this was also the aim of the European Union-funded AP@home project. Over a time period of 5 years a series of clinical studies were performed that culminated in 2 "final studies" during which an AP system was used by patients in their home environment for 2 or 3 months without supervision by a physician, living their normal lives. Two different versions of the AP system developed within this project were evaluated. A significant improvement in glycated hemoglobin was observed during closed-loop conditions despite the fact that during the control period the patients used the best currently available therapeutic option. In addition, a "single-port AP system" was developed within the project that combines continuous glucose monitoring and insulin infusion at a single tissue site. By using such a combined device the patients not only have to carry one less device around, the number of access points through the skin is also reduced from 2 to 1. In summary, close cooperation of 12 European partners, both academic centers and industry, enabled the development and evaluation of AP systems under daily life conditions. The next step is to develop these into products in cooperation with commercial partners. PMID:26888971

  20. ESA `Huygens and Mars Express' science highlights - call to press

    NASA Astrophysics Data System (ADS)

    2005-11-01

    Almost one year has passed since ESA’s Huygens probe landed on Saturn’s largest moon, Titan. Today, a set of new wide-ranging results from the probe’s two-and-a-half hour descent and landing, part of the extraordinary NASA/ESA/ASI Cassini-Huygens mission to Saturn and its moons, is ready for release. At the same time, ESA’s Mars Express mission is continuing its investigations of Mars, painting a new picture of the 'red planet'. This includes the first ever probing below the surface of Mars, new geological clues with implications for the climate, newly-discovered surface and atmospheric features and, above all, traces of the presence of water on this world. These and other exciting findings from just one year of observations and data analysis - in the context of ESA’s overall scientific achievements - will be the focus of a press conference to be held at ESA Headquarters in Paris at 16:00 on 30 November 2005. Media interested in attending are invited to complete the following registration form. Press conference programme Space Science Highlights 2005 From Huygens to Mars Express 30 November 2005, 16:00 hrs Room 137, European Space Agency Headquarters 8-10 Rue Mario-Nikis, F-75738 Paris Cedex, France 15:30 - Registration 16:00 - A Year of European Space Science Successes Prof. David Southwood, ESA Director of Science Programme 16:10 - Highlights of the Huygens Mission Results Jean-Pierre Lebreton, ESA Huygens Project Scientist 16:15 - Robin Duttaroy, Co-Investigator, Doppler Wind Experiment, University of Bonn, Germany 16:20 - Marcello Fulchignoni , Principal Investigator, Huygens Atmospheric Structure Instrument, Université de Paris 7, France 16:25 - John Zarnecki, Principal Investigator, Surface Science Package, Open University, UK 16:30 - François Raulin, Co-Investigator, Gas Chromatograph Mass Spectrometer, Université de Paris 12 - Créteil, France 16:35 - Guy Israel, Principal Investigator, Aerosol Collector and Pyrolyser, Service d

  1. Exploring Mars: The Ares Payload Service (APS)

    NASA Astrophysics Data System (ADS)

    Bowen, Justin; Lusignan, Bruce

    1999-08-01

    In last year's Mars Society convention we introduced the results of five years of studies of space launch capability for the second millennium. We concluded that Single Stage to Orbit (SSTO) vehicles such as the Delta Clipper X33, and X34 cannot make it to orbit from the Earth's surface. Whether taking off vertically or horizontally or landing vertically or horizontally, the rocket equations, the performance of available fuels, and the realities of the weight and strength of materials leave no margin for payload. The promised savings from SSTO systems are illusory. However, a configuration that is able to deliver useful payload to orbit is the Single step to Orbit, SsTO, a rocket plane that is released fully fueled, from 35,000 to 40,000 feet altitude. Three approaches have been proposed. The Hot'l and Molnya Corporation designs carry the fueled rocket plane to altitude on the back of a carrier aircraft. In this design the carrier aircraft is Russia's Antonov 225 the world's largest cargo plane. The rocket plane is a modified version of the Buran, Russia's own space shuttle. Another configuration is Kelly Aviation's concept in which the fully fueled rocket plane is towed to altitude by the cargo plane and then released. A third approach is based on the early "X" planes, which were dropped from the belly of the carrier plane. While the rocket equations indicate that these three concepts can deliver useful payloads, the Stanford review found significant advantages to the approach of Pioneer Rocket, in which the rocket plane flies up to the carrier plane with conventional jet engines, docks, and then loads on the oxidizer for the flight to orbit. This architecture has more reasonable abort modes in case of system failure in either aircraft and can deliver a larger final payload to orbit for a given sized carrier. The Stanford recommendation is that the carrier aircraft be the Antonov 225. A design based on this was presented in a report last year. Refinements to the

  2. Exploring Mars: the Ares Payload Service (APS)

    NASA Technical Reports Server (NTRS)

    Bowen, Justin; Lusignan, Bruce

    1999-01-01

    In last year's Mars Society convention we introduced the results of five years of studies of space launch capability for the second millennium. We concluded that Single Stage to Orbit (SSTO) vehicles such as the Delta Clipper X33, and X34 cannot make it to orbit from the Earth's surface. Whether taking off vertically or horizontally or landing vertically or horizontally, the rocket equations, the performance of available fuels, and the realities of the weight and strength of materials leave no margin for payload. The promised savings from SSTO systems are illusory. However, a configuration that is able to deliver useful payload to orbit is the Single step to Orbit, SsTO, a rocket plane that is released fully fueled, from 35,000 to 40,000 feet altitude. Three approaches have been proposed. The Hot'l and Molnya Corporation designs carry the fueled rocket plane to altitude on the back of a carrier aircraft. In this design the carrier aircraft is Russia's Antonov 225 the world's largest cargo plane. The rocket plane is a modified version of the Buran, Russia's own space shuttle. Another configuration is Kelly Aviation's concept in which the fully fueled rocket plane is towed to altitude by the cargo plane and then released. A third approach is based on the early "X" planes, which were dropped from the belly of the carrier plane. While the rocket equations indicate that these three concepts can deliver useful payloads, the Stanford review found significant advantages to the approach of Pioneer Rocket, in which the rocket plane flies up to the carrier plane with conventional jet engines, docks, and then loads on the oxidizer for the flight to orbit. This architecture has more reasonable abort modes in case of system failure in either aircraft and can deliver a larger final payload to orbit for a given sized carrier. The Stanford recommendation is that the carrier aircraft be the Antonov 225. A design based on this was presented in a report last year. Refinements to the

  3. Simultaneous recording of t-tubular electrical activity and Ca2+-release in heart failure

    NASA Astrophysics Data System (ADS)

    Crocini, C.; Coppini, R.; Ferrantini, C.; Yan, P.; Loew, L.; Tesi, C.; Poggesi, C.; Cerbai, E.; Pavone, F. S.; Sacconi, L.

    2014-05-01

    T-tubules (TT) are invaginations of the surface sarcolemma (SS) that mediate the rapid propagation of the action potential (AP) to the cardiomyocyte core. We employed the advantages of an ultrafast random access multi-photon (RAMP) microscope (Sacconi et al., PNAS 2012) with a double staining approach to optically record t-tubular AP and, simultaneously, the corresponding local Ca2+-release in different positions across the cardiomyocytes. Despite a uniform AP between SS and TT at steady-state stimulation, in control cardiomyocytes we observed a non-negligible be variability of local Ca2+-transient amplitude and kinetics. This variability was significantly reduced by applying 0.1μM Isoproterenol, which increases the opening probability of Ca2+-release units. In the rat heart failure model (HF), we previously demonstrated that some tubular elements fail to propagate AP. We found that the tubules unable to propagate AP, displayed a reduced correspondent Ca2+-transient amplitude as well as a slower Ca2+ rise compared to electrically coupled tubules. Moreover variability of Ca2+-transient kinetics were increased in HF. Finally, TT that did not show AP, occasionally exhibited spontaneous depolarizations that were never accompanied by local Ca2+-release in the absence of any pro-arrhythmogenic stimulation. Simultaneous recording of AP and Ca2+-transient allows us to probe the spatio-temporal variability of Ca2+-release, whereas the investigation of Ca2+-transient in HF discloses an unexpected uncoupling between t-tubular depolarization and Ca2+-release in remodeled tubules. This work was funded by the European Union 7th Framework Program (FP7/2007- 2013) under grant agreement n° 284464, 241526, by the Italian Ministry of University and Research (NANOMAX), and by Telethon-Italy (GGP13162).

  4. Functional Analysis of AP-2 α and μ2 Subunits

    PubMed Central

    Motley, Alison M.; Berg, Nicola; Taylor, Marcus J.; Sahlender, Daniela A.; Hirst, Jennifer; Owen, David J.

    2006-01-01

    The AP-2 adaptor complex plays a key role in cargo recognition and clathrin-coated vesicle formation at the plasma membrane. To investigate the functions of individual binding sites and domains of the AP-2 complex in vivo, we have stably transfected HeLa cells with wild-type and mutant small interfering RNA–resistant α and μ2 subunits and then used siRNA knockdowns to deplete the endogenous proteins. Mutating the PtdIns(4,5)P2 binding site of α, the phosphorylation site of μ2, or the YXXΦ binding site of μ2 impairs AP-2 function, as assayed by transferrin uptake. In contrast, removing the C-terminal appendage domain of α, or mutating the PtdIns(4,5)P2 binding site of μ2, has no apparent effect. However, adding a C-terminal GFP tag to α renders it completely nonfunctional. These findings demonstrate that there is some functional redundancy in the binding sites of the various AP-2 subunits, because no single mutation totally abolishes function. They also help to explain why GFP-tagged AP-2 never appears to leave the plasma membrane in some live cell imaging studies. Finally, they establish a new model system that can be used both for additional structure-function analyses, and as a way of testing tagged constructs for function in vivo. PMID:17035630

  5. The Relationship between Advanced Placement and College Graduation. 2005 AP Study Series, Report 1

    ERIC Educational Resources Information Center

    Dougherty, Chrys; Mellor, Lynn; Jian, Shuling

    2006-01-01

    This study explores the relationship between college graduation rates and student participation and success in Advanced Placement (AP) courses and exams. We reviewed three approaches to examining this relationship: 1) comparing the college graduation rates of AP and non-AP students; 2) comparing the college graduation rate of AP and non-AP…

  6. AP Report to the Nation: A Closer Look at the Nation and Florida

    ERIC Educational Resources Information Center

    Sawtell, Ellen A.; Gillie, Jacqueline M.; Smith, Patricia Z.

    2012-01-01

    In February 2012, the College Board published The 8th Annual AP Report to the Nation. This session provides a deeper dive into key information for the United States with an emphasis on Florida, and participants hear how one school in Florida utilizes AP Potential™ to help build their AP Program. Participants also learn about AP participation and…

  7. Past, Present, and Future of AP Chemistry: A Brief History of Course and Exam Alignment Efforts

    ERIC Educational Resources Information Center

    Magrogan, Serena

    2014-01-01

    As part of the Advanced Placement (AP) Program's commitment to continually enhance alignment with current best practices in college-level learning, the AP Program is currently evaluating and redesigning courses and exams, one of which launched during the 2013-2014 academic school year: AP chemistry. The history of the AP chemistry course and…

  8. Experience with the EPICS PV Gateway at the APS.

    SciTech Connect

    Evans, K. Jr.; Smith, M.; Accelerator Systems Division

    2006-01-01

    The EPICS Process Variable Gateway has become a stable, high-performance application that provides access to process variables while minimizing the impact on critical Input-Output Controllers (IOCs) and implementing additional access security. The additional access security typically prevents write access but is highly configurable. The Advanced Photon Source (APS) currently uses 40 Gateways running on 11 workstations to provide access to the machine subnet from the offices and for the individual experimental teams. These include reverse Gateways that allow administration of all 40 APS Gateways from a single MEDM screen, even though the Gateways are running on separate networks. This administration includes starting, stopping, making and viewing reports, and viewing and editing access security files. There is one Gateway that provides process variable renaming. This paper provides an overview of the Gateways at the APS and describes the procedures that have been set up to use and administer them.

  9. A survey of Ap stars for weak longitudinal magnetic fields

    NASA Astrophysics Data System (ADS)

    Auriere, M.; Silvester, J.; Wade, G. A.; Bagnulo, S.; Donati, J. F.; Johnson, N.; Landstreet, J. D.; Lignieres, F.; Lueftinger, T.; Mouillet, M.; Paletou, F.; Petit, P.; Strasser, S.

    2004-10-01

    We are conducting a magnetic survey of a sample of about 30 spectroscopically-identified Ap stars (selected from the HD catalogue), but with faint or previously undetected magnetic fields. We use the MuSiCoS spectropolarimeter at Telescope Bernard Lyot (Pic du Midi Observatory, France) and the cross-correlation technique Least Squares Deconvolution (LSD; Donati et al. 1997). For 24 studied stars, we have obtained 21 detections of Stokes V Zeeman signatures (data quality and phase coverage may explain our lack of detection of any field in some objects). Our results suggest that all Ap stars are magnetic and, furthermore, that there may exist a minimum field strength for which Ap-type characteristics are produced.

  10. The fundamental parameters of the Ap star 78 Virginis. Could 78 Vir be a rapidly oscillating Ap star?

    NASA Astrophysics Data System (ADS)

    Perraut, K.; Cunha, M.; Brandão, I.; Loridat, J.; Mourard, D.; Meilland, A.; Nardetto, N.; McAlister, H.; ten Brummelaar, T. A.; Sturmann, J.; Sturmann, L.; Turner, N.; Farrington, C.; Vargas, N.

    2015-07-01

    Context. Determining the effective temperature of Ap stars, including the roAp stellar pulsators, is a difficult task owing to their strong magnetic field and their related spotted surfaces. It is, however, an important step towards constraining models of their complex atmosphere and testing proposed pulsation excitation mechanisms. Aims: Using the unique angular resolution provided by long-baseline visible interferometry, we aim at deriving accurate angular diameters of a number of Ap targets, so as to determine their unbiased effective temperature (Teff) and their accurate position in the Hertzsprung-Russell diagram, to estimate their mass and age, and to test non-adiabatic pulsation models. Interferometric results on four Ap stars have been published in earlier works. Here we report the results on a fifth, significantly hotter star. Methods: We observed 78 Vir with the visible spectrograph VEGA installed at the combined focus of the CHARA long-baseline optical array. We derived the limb-darkened diameter of this Ap star from our interferometric measurements. Based on photometric and spectroscopic data available in the literature, we estimated the star's bolometric flux and used it, in combination with its parallax and angular diameter, to determine the star's luminosity and effective temperature. We then used the derived fundamental parameters to perform a non-adiabatic pulsation analysis. Results: We determined a limb-darkened angular diameter of 0.346 ± 0.006 mas and deduced a linear radius of R = 2.11 ± 0.04 R⊙. Considering a bolometric flux of 2.73 ± 0.20 10-7 erg/cm2/s we obtained a luminosity of L/L⊙ = 27 ± 2 and an effective temperature of Teff = 9100 ± 190 K. The non-adiabatic pulsation modeling allows us to predict that high overtone pulsations could be excited in 78 Vir at frequencies ranging from 1.2 to 1.9 mHz, provided that the magnetic field is capable of suppressing envelope convection in the polar regions. Conclusions: Visible long

  11. Release and Skin Permeation of Scopolamine From Thin Polymer Films in Relation to Thermodynamic Activity.

    PubMed

    Kunst, Anders; Lee, Geoffrey

    2016-04-01

    The object was to demonstrate if the diffusional flux of the drug out of a drug-in-adhesive-type matrix and its subsequent permeation through an excised skin membrane is a linear function of the drug's thermodynamic activity in the thin polymer film. The thermodynamic activity, ap(*), is defined here as the degree of saturation of the drug in the polymer. Both release and release/permeation of scopolamine base from 3 different poylacrylate pressure-sensitive adhesives (PSAs) were measured. The values for ap(*) were calculated using previous published saturation solubilities, wp(s), of the drug in the PSAs. Different rates of release and release/permeation were determined between the 3 PSAs. These differences could be accounted for quantitatively by correlating with ap(*) rather than the concentration of the drug in the polymer films. At similar values for ap(*) the same release or release/permeation rates from the different polymers were measured. The differences could not be related to cross-linking or presence of ionizable groups of the polymers that should influence diffusivity. PMID:27019963

  12. Psychosocial Assessment of Artificial Pancreas (AP): Commentary and Review of Existing Measures and Their Applicability in AP Research

    PubMed Central

    Hood, Korey K.; Weissberg-Benchell, Jill; Aldred, Chris; Oliver, Nick; Laffel, Lori

    2015-01-01

    Abstract Aim: This study aimed to systematically review the evidence base for the use of existing psychological and psychosocial measures suitable for use in artificial pancreas (AP) research. Materials and Methods: This systematic review of published literature, gray literature, previous systematic reviews, and qualitative and economic studies was conducted using terms and abbreviations synonymous with diabetes, AP, and quality of life (QoL). Results: Two hundred ninety-two abstracts were identified that reported psychosocial assessment of diabetes-related technologies. Of these, nine met the inclusion criteria and were included. Only four of 103 ongoing trials evaluated psychosocial aspects as an outcome in the trial. Of these, treatment satisfaction, acceptance and use intention of AP, fear of hypoglycemia episodes, satisfaction with AP, and an unspecified QoL measure were used. Conclusions: A better understanding of the psychosocial side of AP systems and the extent to which human factors play a role in the uptake and efficient use of these systems will ultimately lead to the most benefit for people with diabetes. PMID:25549042

  13. Status of the Advanced Photon Source (APS) linear accelerator

    SciTech Connect

    White, M.; Arnold, N.; Berg, W.; Cours, A.; Fuja, R.; Grelick, A.; Ko, K.; Qian, Y.; Russell, T.; Sereno, N.

    1994-09-01

    A 2856-MHz S-band, electron-positron linear accelerator (linac) has been constructed at the Advanced Photon Source (APS). It is the source of particles and the injector for the other APS accelerators, and linac commissioning is well underway. The linac is operated 24 hours per day to support linac beam studies and rf conditioning, as well as positron accumulator ring and synchrotron commissioning studies. The design goal for accelerated positron current is 8-mA, and has been met. Maximum positron energy to date is 420-MeV, approaching the design goal of 450-MeV. The linac design and its performance are discussed.

  14. Analysis of the planning and scheduling functionality in APS systems

    NASA Astrophysics Data System (ADS)

    Steger-Jensen, Kenn; Hvolby, Hans-Henrik

    2001-10-01

    The paper discusses the basic functionality of planning and scheduling in Advanced Planning and Scheduling systems (APS). Three basic planning options - unconstrained planning, constrained planning and optimization are analyzed by use of theory and examples based on test of an APS system. Even though the planning functionality are radically improved compared to MRP and MRP II, the balance between the objectives are found to be too rigid. This conclusion is based on a number of examples, comparing the outcome of different objectives such as constraints based planning versus optimized planning.

  15. Piping benchmark problems for the Westinghouse AP600 Standardized Plant

    SciTech Connect

    Bezler, P.; DeGrassi, G.; Braverman, J.; Wang, Y.K.

    1997-01-01

    To satisfy the need for verification of the computer programs and modeling techniques that will be used to perform the final piping analyses for the Westinghouse AP600 Standardized Plant, three benchmark problems were developed. The problems are representative piping systems subjected to representative dynamic loads with solutions developed using the methods being proposed for analysis for the AP600 standard design. It will be required that the combined license licensees demonstrate that their solutions to these problems are in agreement with the benchmark problem set.

  16. Power supply control units for APS ring magnets

    SciTech Connect

    Despe, O.D.

    1990-04-15

    The APS storage ring (1104 meters) is divided into 40 sectors. Each sector has 38 magnet coils in five magnet bases. Every alternate sector has an additional quadrupole magnet for skew correction. AR the main dipole magnets, two in each sector are connected in series and fed from one power supply unit. A base is controlled by one power supply control unit (PSCU). Each PSCU is connected to the host computer via a local area network (LAN). This note discusses the hardware configuration of the typical power supply control system used by the APS magnets and the software commands supported by the PSCU.

  17. 22 CFR 9b.1 - Press access to the Department of State.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Press access to the Department of State. 9b.1 Section 9b.1 Foreign Relations DEPARTMENT OF STATE GENERAL REGULATIONS GOVERNING DEPARTMENT OF STATE PRESS BUILDING PASSES § 9b.1 Press access to the Department of State. (a) Media correspondents without valid Department of State press building...

  18. An Update of Freedom of the Press and Information in Latin America and the Caribbean.

    ERIC Educational Resources Information Center

    Garrison, Bruce; Munoz, Julio E.

    This paper is based on a review of the literature that included reports from the Inter-American Press Association's general assembly in Los Angeles in October 1984, the mid-year meeting of the Inter-American Press Association in Panama City in March 1985, and the 1983 world press freedom review of the International Press Institute. Other material…

  19. 22 CFR 9b.1 - Press access to the Department of State.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Press access to the Department of State. 9b.1 Section 9b.1 Foreign Relations DEPARTMENT OF STATE GENERAL REGULATIONS GOVERNING DEPARTMENT OF STATE PRESS BUILDING PASSES § 9b.1 Press access to the Department of State. (a) Media correspondents without valid Department of State press building...

  20. 22 CFR 9b.1 - Press access to the Department of State.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Press access to the Department of State. 9b.1 Section 9b.1 Foreign Relations DEPARTMENT OF STATE GENERAL REGULATIONS GOVERNING DEPARTMENT OF STATE PRESS BUILDING PASSES § 9b.1 Press access to the Department of State. (a) Media correspondents without valid Department of State press building...

  1. The AP-1 transcription factor homolog Pf-AP-1 activates transcription of multiple biomineral proteins and potentially participates in Pinctada fucata biomineralization

    PubMed Central

    Zheng, Xiangnan; Cheng, Minzhang; Xiang, Liang; Liang, Jian; Xie, Liping; Zhang, Rongqing

    2015-01-01

    Activator protein-1 (AP-1) is an important bZIP transcription factor that regulates a series of physiological processes by specifically activating transcription of several genes, and one of its well-chartered functions in mammals is participating in bone mineralization. We isolated and cloned the complete cDNA of a Jun/AP-1 homolog from Pinctada fucata and called it Pf-AP-1. Pf-AP-1 had a highly conserved bZIP region and phosphorylation sites compared with those from mammals. A tissue distribution analysis showed that Pf-AP-1 was ubiquitously expressed in P. fucata and the mRNA level of Pf-AP-1 is extremely high in mantle. Pf-AP-1 expression was positively associated with multiple biomineral proteins in the mantle. The luciferase reporter assay in a mammalian cell line showed that Pf-AP-1 significantly up-regulates the transcriptional activity of the promoters of KRMP, Pearlin, and Prisilkin39. Inhibiting the activity of Pf-AP-1 depressed the expression of multiple matrix proteins. Pf-AP-1 showed a unique expression pattern during shell regeneration and pearl sac development, which was similar to the pattern observed for biomineral proteins. These results suggest that the Pf-AP-1 AP-1 homolog is an important transcription factor that regulates transcription of several biomineral proteins simultaneously and plays a role in P. fucata biomineralization, particularly during pearl and shell formation. PMID:26404494

  2. Predictable pulsatile release of tramadol hydrochloride for chronotherapeutics of arthritis.

    PubMed

    Dabhi, Chandu; Randale, Shivsagar; Belgamwar, Veena; Gattani, Surendra; Tekade, Avinash

    2010-07-01

    The present investigation deals with the development of a pH and time-dependent press-coated pulsatile drug delivery system for delivering drugs into the colon. The system consists of a drug containing core, coated by a combination of natural polymer Delonix regia gum (DRG) and hydroxypropyl methylcellulose (HPMC K4M) in various proportions, which controls the onset of release. The whole system was coated with methacrylic acid copolymers, which not only prevents the drug release in the stomach, but also prolongs the lag time. Tramadol HCl was used as a model drug and varying combinations of DRG and HPMC K4M were used to achieve the desired lag time before rapid and complete release of the drug in the colon. It was observed that the lag time depends on the coating ratio of DRG to HPMC and also on press coating weight. Drug release was found to be increased by 15-30% in the presence of colonic microbial flora. The results showed the capability of the system in achieving pulsatile release for a programmable period of time and pH-dependent release to attain colon-targeted delivery. PMID:20524906

  3. A Study on the Specifications of Cold Pressed Colza Oil.

    PubMed

    Yazdani-Nasab, Zahra; Piravi-Vanak, Zahra

    2015-01-01

    Cold pressed oil extraction is the preferred method for seeds with high contents of oil, such as colza. Generally speaking, expeller pressing is less complex, more cost efficient and safer than solvent extraction. Moreover, cold pressed oils retain their natural properties better. Cold pressed colza oil has been found to have numerous health benefits. This was an original and unique study conducted as part of the research for the international Codex standard for cold pressed fats and oils, and aims to examine the chemical properties of two varieties of Iranian colza seed, Hyola and Okapi. The studied factors included (a) chemical properties, and (b) physicochemical and quality characteristics. Based on our findings, both varieties of colza seeds in this study had satisfactory levels of oleic and linoleic acid, and no trans-fatty acids. Although both samples had good nutritional properties, the Hyola variety was higher in oleic acid, indicating better oxidative stability. Due to the considerable amounts of β-sitosterol in both varieties, they may be effective in reducing cholesterol and preventing cancer. PMID:26043928

  4. Bilberry and bilberry press cake as sources of dietary fibre

    PubMed Central

    Aura, Anna-Marja; Holopainen-Mantila, Ulla; Sibakov, Juhani; Kössö, Tuija; Mokkila, Mirja; Kaisa, Poutanen

    2015-01-01

    Background Dietary recommendations for Nordic countries urge the use of plant foods as a basis for healthy nutrition. Currently, the level of dietary fibre (DF) intake is not adequate. Berries are an elementary part of the recommended Nordic healthy diet and could be consumed in higher amounts. Materials and methods Finnish bilberries and a bilberry press cake from juice processing were studied for DF content, carbohydrate composition, and non-carbohydrate fibre content, which was analysed as sulphuric acid insoluble and soluble material. The microstructure of all samples was also studied using light microscopy and toluidine blue O, calcofluor, and acid fuchsin staining. Results The total DF contents of fresh and freeze-dried bilberries and the press cake were 3.0, 24.1, and 58.9%, respectively. Most of the DF was insoluble. Only about half of it was carbohydrate, the rest being mostly sulphuric acid–insoluble material, waxy cutin from skins, and resilient seeds. Bilberry seeds represented over half of the press cake fraction, and in addition to skin, they were the major DF sources. Microscopy revealed that skins in the press cake were intact and the surface of the seeds had thick-walled cells. Conclusions Bilberry press cake is thus a good source of insoluble non-carbohydrate DF, and could be used to provide DF-rich foods to contribute to versatile intake of DF. PMID:26652738

  5. Quality parameters for cold pressed edible argan oils.

    PubMed

    Matthäus, Bertrand

    2013-01-01

    Argan oil belongs to the high-price vegetable oils on the market. Therefore, consumers have the right to purchase a high-quality product. The quality of edible vegetable oils is defined in food standards in which sensory quality is the most important feature. Additional parameters are defined to assess the identity of oils or to evaluate their oxidative state. The sensory quality of cold pressed argan oil is altered if the production has not been performed with reasonable care regarding raw material and extraction. Only oil from roasted seeds extracted by a screw-press had a sufficient sensory quality over a period of 20 weeks without unacceptable sensory attributes. Under accelerated storage conditions oil from roasted seeds extracted by a screw-press remained below the limits given by the Codex Alimentarius or the German guideline for Edible Fats and Oils for peroxide and totox value. Oil from unroasted seeds or oil from goat-digested roasted seeds and extracted by a screw-press, as well as oil from roasted seeds traditionally extracted, exceeded these limits. Initial oxidative stability of oil from unroasted seeds was significantly lower than that of the other oils. After 35 days under accelerated storage, oil from roasted seeds obtained using a screw-press showed the highest oxidative stability. Moreover, tocopherol and phytosterol compositions are useful features of argan oil. PMID:23472455

  6. The AE9/AP9/SPM Next Generation Radiation Specification Models - Progress Report

    NASA Astrophysics Data System (ADS)

    O'Brien, Paul; Johnston, William Robert; Huston, Stuart; Guild, Timothy

    2016-07-01

    The AE9/AP9/SPM model has now been released to the global satellite design community, with a recent update to version 1.2. We are working on incorporating new data sources, such as AZUR and NASA's Van Allen Probes, while also addressing critiques raised by the science and engineering communities. In particular, we are investigating discrepancies for protons at low altitude and electrons at geostationary altitudes. Finally, we are scoping out architectural improvements to enable features requested by industry: improved stitching between the plasma and radiation models, local time dependence in the plasma model, longitude dependence in the electron radiation model, and solar cycle variation in the low altitude protons. We provide a brief update on the status of the model, discrepancy investigations, and plans for the future.

  7. Validation of the new trapped environment AE9/AP9/SPM at low Earth orbit

    NASA Astrophysics Data System (ADS)

    Badavi, Francis F.

    2014-09-01

    The completion of the international space station (ISS) in 2011 has provided the space research community an ideal proving ground for future long duration human activities in space. Ionizing radiation measurements in ISS form the ideal tool for the validation of radiation environmental models, nuclear transport codes and nuclear reaction cross sections. Indeed, prior measurements on the space transportation system (STS; shuttle) provided vital information impacting both the environmental models and the nuclear transport code developments by indicating the need for an improved dynamic model of the low Earth orbit (LEO) trapped environment. Additional studies using thermo-luminescent detector (TLD), tissue equivalent proportional counter (TEPC) area monitors, and computer aided design (CAD) model of earlier ISS configurations, confirmed STS observations that, as input, computational dosimetry requires an environmental model with dynamic and directional (anisotropic) behavior, as well as an accurate six degree of freedom (DOF) definition of the vehicle attitude and orientation along the orbit of ISS. At LEO, a vehicle encounters exposure from trapped particles and attenuated galactic cosmic rays (GCR). Within the trapped field, a challenge arises from properly estimating the amount of exposure acquired. There exist a number of models to define the intensities of the trapped particles during the solar quiet and active times. At active times, solar energetic particles (SEP) generated by solar flare or coronal mass ejection (CME) also contribute to the exposure at high northern and southern latitudes. Among the more established trapped models are the historic and popular AE8/AP8, dating back to the 1980s, the historic and less popular CRRES electron/proton, dating back to 1990s and the recently released AE9/AP9/SPM. The AE9/AP9/SPM model is a major improvement over the older AE8/AP8 and CRRES models. This model is derived from numerous measurements acquired over four

  8. Solutions to Challenges Facing a University Digital Library and Press

    PubMed Central

    D'Alessandro, Michael P.; Galvin, Jeffrey R.; Colbert, Stephana I.; D'Alessandro, Donna M.; Choi, Teresa A.; Aker, Brian D.; Carlson, William S.; Pelzer, Gay D.

    2000-01-01

    During the creation of a university digital library and press intended to serve as a medical reference and education tool for health care providers and their patients, six distinct and complex digital publishing challenges were encountered. Over nine years, through a multidisciplinary approach, solutions were devised to the challenges of digital content ownership, management, mirroring, translation, interactions with users, and archiving. The result is a unique, author-owned, internationally mirrored, university digital library and press that serves as an authoritative medical reference and education tool for users around the world. The purpose of this paper is to share the valuable digital publishing lessons learned and outline the challenges facing university digital libraries and presses. PMID:10833161

  9. Natural Hazards and the press in the western Mediterranean region

    NASA Astrophysics Data System (ADS)

    Llasat-Botija, M.; Llasat, M. C.; López, L.

    2007-07-01

    This study analyses press articles published between 1982 and 2005 in an attempt to describe the social perception of natural hazards in Catalonia. The articles included in the database have been classified according to different types of risk. In addition, the study examines the evolution of each type of risk in the press coverage during the study period. Finally, the results have been compared to data provided by insurance companies with respect to compensations paid out for damages. Conclusions show that floods are the most important natural hazard in the region, but that the number of headlines for each event is greater in the case of snowfalls and forest fires. Factors such as the season of the year, the proximity of the affected region to the capital, the topical issues at the time, and the presence of other important news must be considered when the impact in the press is analysed.

  10. Joining of ceramics of different biofunction by hot isostatic pressing

    SciTech Connect

    Li, Jianguo . Center for Dental Technology and Biomaterials); Harmansson, L. ); Soeremark, R. . Dept. of Prosthodontics)

    1993-10-01

    Monolithic zirconia (Z) and zirconia-hydroxyapatite (Z/HA) composites were joined by cold isostatic pressing (CIP at 300 MPa) and subsequently by glass-encapsulated hot isostatic pressing (HIP at 1225 C, 1 h and 200 MPa). The physical and mechanical properties of the materials were measured. The fracture surface was studied using a light microscope. The results indicate a strength level of the joint similar to that of the corresponding composite material (Z/HA), 845 and 860 MPa, respectively. Similar experiments with monolithic alumina (A) and alumina-hydroxyapatite (A/HA) were carried out without success. Cracking occurred in the joint area during the cold isostatic pressing process. It seems that ceramics with high green strength and similar green density are essential when joining ceramics by combined CIP and HIP processes.

  11. Method for hot pressing irregularly shaped refractory articles

    DOEpatents

    Steinkamp, William E.; Ballard, Ambrose H.

    1982-01-01

    The present invention is directed to a method for hot pressing irregularly haped refractory articles with these articles of varying thickness being provided with high uniform density and dimensional accuracy. Two partially pressed compacts of the refractory material are placed in a die cavity between displaceable die punches having compact-contacting surfaces of the desired article configuration. A floating, rotatable block is disposed between the compacts. The displacement of the die punches towards one another causes the block to rotate about an axis normal to the direction of movement of the die punches to uniformly distribute the pressure loading upon the compacts for maintaining substantially equal volume displacement of the powder material during the hot pressing operation.

  12. Crack toughness evaluation of hot pressed and forged beryllium

    NASA Technical Reports Server (NTRS)

    Jones, M. H.; Bubsey, R. T.; Brown, W. F., Jr.

    1971-01-01

    Beryllium fracture toughness test specimens were fatigue cracked using reversed cycling with a compression load two to three times the tension load. In worked beryllium, textures may be produced which result in fatigue cracks that are out of plane with the starter notch. Specimens of hot pressed stock exhibited load displacement records which were nonlinear throughout their course. Fracture specimens of both hot pressed and forged stock showed essentially no reduction of thickness and the fracture surfaces were flat and normal to the load axis. However, the stress intensity factor at maximum load increased with decreasing thickness. Load-displacement and electric potential records for the hot pressed beryllium specimens exhibited several anomalies such as negative residual crack mouth displacements and a decrease in electrical potential with increasing load.

  13. Thermal conductance of pressed contacts at liquid helium temperatures

    NASA Technical Reports Server (NTRS)

    Salerno, L. J.; Kittel, P.; Spivak, A. L.

    1983-01-01

    It is pointed out that the optimum design of cryogenic instruments requires accurate thermal models. The present models are limited by a lack of knowledge of the low temperature thermal conductance of the bolted joints which are typically used in the instrument-to-system interface. In connection with studies of pressed contacts, it has been found that the thermal conductance does not obey the Wiedemann-Franz law. The present investigation is concerned with the characterization of the thermal conductance of pressed contacts at liquid helium-4 temperatures, taking into account the dependence of thermal contact conductance on applied force and temperature. It is shown that for the 0.4 micron OFHC copper pressed contact pair, the thermal conductance varies roughly as the second power of the temperature, and increases with increasing applied force.

  14. Spatial distribution and compositional variation of APS minerals related to uranium deposits in the Kiggavik-Andrew Lake structural trend, Nunavut, Canada

    NASA Astrophysics Data System (ADS)

    Riegler, Thomas; Quirt, Dave; Beaufort, Daniel

    2016-02-01

    The Kiggavik-Andrew Lake structural trend consists of four mineralized zones, partially outcropping, lying 2 km south of the erosional contact with the unmetamorphosed sandstone and basal conglomerates of the Paleoproterozoic Thelon Formation. The mineralization is controlled by a major E-W fault system associated with illite and sudoite alteration halos developed in the Archean metagraywackes of the Woodburn Lake Group. Aluminum phosphate sulfate (APS) minerals from the alunite group crystallized in association with the clay minerals in the basement alteration halo as well as in the overlying sandstones, which underwent mostly diagenesis. APS minerals are Sr- and S-rich (svanbergite end-member) in the sedimentary cover overlying the unconformity, whereas they are light rare earth elements (LREE)-rich (florencite end-member) in the altered basement rocks below the unconformity. The geochemical signature of each group of APS minerals together with the petrography indicates three distinct generations of APS minerals related to the following: (1) paleoweathering of continental surfaces prior to the basin occurrence, (2) diagenetic processes during the burial history of the lower unit of the Thelon sandstones, and (3) hydrothermal alteration processes which accompanied the uranium deposition in the basement rocks and partially overlap the sedimentary-diagenetic mineral parageneses. In addition, the association of a first generation of APS minerals with both detrital cerium oxide and aluminum oxy-hydroxide highlights the fact that a part of the detrital material of the basal Thelon Formation originated from eroded paleolaterite (allochthonous regolith). The primary rare earth element (REE)-bearing minerals (e.g., monazite, REE carbonates, and allanite) of the host rocks were characterized to identify the potential sources of REE. The REE chemical composition highlights a local re-incorporation of the REE released from the alteration processes in the APS minerals of

  15. Chemical release module facility

    NASA Technical Reports Server (NTRS)

    Reasoner, D. L.

    1980-01-01

    The chemical release module provides the capability to conduct: (1) thermite based metal vapor releases; (2) pressurized gas releases; (3) dispersed liquid releases; (4) shaped charge releases from ejected submodules; and (5) diagnostic measurements with pi supplied instruments. It also provides a basic R-F and electrical system for: (1) receiving and executing commands; (2) telemetering housekeeping data; (3) tracking; (4) monitoring housekeeping and control units; and (5) ultrasafe disarming and control monitoring.

  16. New applications of roller presses in coal-related technologies

    SciTech Connect

    Pietsch, W.; Guenter, H.

    1993-12-31

    The roller press was invented around the middle of the 19th century. Its objective was to develop an economic method for the agglomeration of coal fines. The first successfully operating machine was constructed by the Belgian Louiseau and was installed in a US coal briquetting plant in the late 1870s; therefore this type of equipment was later also referred to as {open_quotes}Belgian Press{close_quotes}. Until the middle of this century many manufacturers produced roller presses and a large number of plants was built, particularly in Europe, to produce mostly egg-shaped briquettes from hard coal fines with coal tar pitch or bitumen as a binder. These briquettes were used as fuel for home and industrial heating. After other, cleaner sources of energy, such as gas, oil, and electricity, became affordable, coal briquetting lost its importance. A small number of almost historic plants is still operating but construction of new ones is scarce. Only a few manufacturers of roller presses are still offering such equipment, mostly for other applications. Recently, a renewed interest in roller presses has developed in connection with innovative coal technologies. These include: Briquetting of non-coking coal for the generation of {open_quotes}form-coke{close_quotes}; production of smoke-less coal briquettes; briquetting of coal for gasification or liquefication techniques; size enlargement by briquetting of fine, upgraded coals, e.g. dried sub-bituminous coal or products from advanced coal cleaning processes, to improve their transport and handling properties; agglomeration of by-products from flue gas desulfurization; and, last but not least, briquetting of coal ashes to allow disposal or beneficial use. In the following such new applications of roller presses for coal related technologies will be reviewed and features of modern machines which are required for their successful operations will be described.

  17. Accuracy of press reports on gamma-ray astronomy

    NASA Astrophysics Data System (ADS)

    Schaefer, Bradley E.; Nemiroff, Robert J.; Hurley, Kevin

    2000-09-01

    Most Americans learn about modern science from press reports, while such articles have a bad reputation among scientists. We have performed a study of 148 news articles on gamma-ray astronomy to quantitatively answer the questions ``How accurate are press reports of gamma-ray astronomy?'' and ``What fraction of the basic claims in the press are correct?'' We have taken all articles on the topic from five news sources (UPI, New York Times, Sky & Telescope, Science News, and five middle-sized city newspapers) for one decade (1987-1996) We found an average rate of roughly one trivial error every two articles, while none of our 148 articles significantly mislead the reader or misrepresented the science. This quantitative result is in stark contrast to the nearly universal opinion among scientists that the press frequently butchers science stories. So a major result from our study is that reporters should be rehabilitated into the good graces of astrophysicists, since they actually are doing a good job. For our second question, we rated each story with the probability that its basic new science claim is correct. We found that the average probability over all stories is 70%. Since the reporters and the scientists are both doing good jobs, then why is 30% of the science you read in the press wrong? The reason is that the nature of news reporting is to present front-line science and the nature of front-line science is that reliable conclusions have not yet been reached. The combination of these two natures forces fast breaking science news to have frequent incorrect ideas that are subsequently identified and corrected. So a second major result from our study is to make the distinction between textbook science (with reliabilities near 100%) and front-line science which you read about in the press (with reliabilities near 70%). .

  18. Process design of press hardening with gradient material property influence

    SciTech Connect

    Neugebauer, R.; Schieck, F.; Rautenstrauch, A.

    2011-05-04

    Press hardening is currently used in the production of automotive structures that require very high strength and controlled deformation during crash tests. Press hardening can achieve significant reductions of sheet thickness at constant strength and is therefore a promising technology for the production of lightweight and energy-efficient automobiles. The manganese-boron steel 22MnB5 have been implemented in sheet press hardening owing to their excellent hot formability, high hardenability, and good temperability even at low cooling rates. However, press-hardened components have shown poor ductility and cracking at relatively small strains. A possible solution to this problem is a selective increase of steel sheet ductility by press hardening process design in areas where the component is required to deform plastically during crash tests. To this end, process designers require information about microstructure and mechanical properties as a function of the wide spectrum of cooling rates and sequences and austenitizing treatment conditions that can be encountered in production environments. In the present work, a Continuous Cooling Transformation (CCT) diagram with corresponding material properties of sheet steel 22MnB5 was determined for a wide spectrum of cooling rates. Heating and cooling programs were conducted in a quenching dilatometer. Motivated by the importance of residual elasticity in crash test performance, this property was measured using a micro-bending test and the results were integrated into the CCT diagrams to complement the hardness testing results. This information is essential for the process design of press hardening of sheet components with gradient material properties.

  19. Process design of press hardening with gradient material property influence

    NASA Astrophysics Data System (ADS)

    Neugebauer, R.; Schieck, F.; Rautenstrauch, A.

    2011-05-01

    Press hardening is currently used in the production of automotive structures that require very high strength and controlled deformation during crash tests. Press hardening can achieve significant reductions of sheet thickness at constant strength and is therefore a promising technology for the production of lightweight and energy-efficient automobiles. The manganese-boron steel 22MnB5 have been implemented in sheet press hardening owing to their excellent hot formability, high hardenability, and good temperability even at low cooling rates. However, press-hardened components have shown poor ductility and cracking at relatively small strains. A possible solution to this problem is a selective increase of steel sheet ductility by press hardening process design in areas where the component is required to deform plastically during crash tests. To this end, process designers require information about microstructure and mechanical properties as a function of the wide spectrum of cooling rates and sequences and austenitizing treatment conditions that can be encountered in production environments. In the present work, a Continuous Cooling Transformation (CCT) diagram with corresponding material properties of sheet steel 22MnB5 was determined for a wide spectrum of cooling rates. Heating and cooling programs were conducted in a quenching dilatometer. Motivated by the importance of residual elasticity in crash test performance, this property was measured using a micro-bending test and the results were integrated into the CCT diagrams to complement the hardness testing results. This information is essential for the process design of press hardening of sheet components with gradient material properties.

  20. AP: A Critical Examination of the Advanced Placement Program

    ERIC Educational Resources Information Center

    Sadler, Philip M., Ed.; Sonnert, Gerhard, Ed.; Tai, Robert H., Ed.; Klopfenstein, Kristin, Ed.

    2010-01-01

    With an annual yearly growth rate of 9.3 percent over the last two decades, Advanced Placement courses have become a juggernaut in American high school education. AP courses are routinely perceived as an indicator of educational rigor, and many schools push to enroll low-income or minority students in these courses in the hope of preparing them…

  1. The nature of the rapidly oscillating Ap stars' pulsations

    NASA Astrophysics Data System (ADS)

    Cunha, M. S.; Perraut, K.

    2013-12-01

    Chemically peculiar stars are stage to a wide variety of physical phenomena, including diffusion, convection, magnetism and pulsation. Progress in the understanding of these objects, through the study of their oscillations, can help us to characterize these physical phenomena and better understand the way they are coupled in stars. A number of chemically peculiar A-type stars, known as rapidly oscillating Ap (roAp) stars, have been known to exhibit high frequency oscillations since the early 80s. Despite this, the mechanism responsible for driving these oscillations is not fully understood. Currently, the most widely accepted theory states that oscillations in this class of pulsators are excited by the opacity mechanism acting on the hydrogen ionization region, in an envelope where convection has been suppressed by a strong magnetic field. Nevertheless, this theory fails to correctly predict some of the observations for this class of pulsators. In this paper we briefly review the current status of understanding of the driving of pulsations in roAp stars. In particular, we shall emphasize the comparison between predictions of nonadiabatic models of roAp stars with observations of a subset of pulsators of this class for which stringent data on global parameters are available.

  2. Intermediate-break LOCA analyses for the AP600 design

    SciTech Connect

    Boyack, B.E.; Lime, J.F.

    1995-07-01

    A postulated double-ended guillotine break of a direct-vessel-injection line in an AP600 plant has been analyzed. This event is characterized as an intermediate break loss-of-coolant accident (IBLOCA). Most of the insights regarding the response of the AP600 safety systems to the postulated accident are derived from calculations performed with the TRAC-PFl/MOD2 code. However, complementary insights derived from a scaled experiment conducted in the ROSA facility, as well as insights based upon calculations by other codes, are also presented. The key processes occurring in an AP600 during a IBLOCA are primary coolant system depressurization, inventory depletion, inventory replacement via emergency core coolant injection, continuous core cooling, and long-term decay heat rejection to the atmosphere. Based upon the calculated and experimental results, the AP600 will not experience a core heat up and will reach a safe shutdown state using only safety-class equipment. Only the early part of the long-term cooling period initiated by In-containment Refueling Water Storage Tank injection was evaluated Thus, the observation that the core is continuously cooled should be verified for the latter phase of the long-term cooling period, the interval when sump injection and containment cooling processes are important.

  3. 76 FR 82079 - AP1000 Design Certification Amendment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-30

    ... any person. The NRC originally approved the AP1000 design certification in a final rule in 2006 (71 FR... notice of acceptance (ADAMS Accession No. ML073600743) in the Federal Register (73 FR 4926; January 28... applications: . Vogtle, Units 3 and 4......... Docket No. 05200025/6. 73 FR 33118. Bellefonte Nuclear...

  4. Time Trials--An AP Physics Challenge Lab

    ERIC Educational Resources Information Center

    Jones, David

    2009-01-01

    I have come to the conclusion that for high school physics classroom and laboratory experiences, simpler is better! In this paper I describe a very simple and effective lab experience that my AP students have thoroughly enjoyed year after year. I call this lab exercise "Time Trials." The experiment is simple in design and it is a lot of fun for…

  5. APS storage ring vacuum chamber: Section 1, Evaluation

    SciTech Connect

    Benaroya, R.; Roop, B.

    1995-07-01

    The vacuum characteristics of the APS storage ring vacuum chamber prototype, Section One (S1), is presented. The base pressure achieved was 4 {times} 10{sup {minus}11}, the welds contained no virtual or real leaks, the NeG strip mounting design and activation procedures have been determined, and S1 was found contaminated with hydrocarbons.

  6. Integrating Particulate Representations into AP Chemistry and Introductory Chemistry Courses

    ERIC Educational Resources Information Center

    Prilliman, Stephen G.

    2014-01-01

    The College Board's recently revised curriculum for advanced placement (AP) chemistry places a strong emphasis on conceptual understanding, including representations of particle phenomena. This change in emphasis is informed by years of research showing that students could perform algorithmic calculations but not explain those calculations…

  7. Automated Procurement System (APS) revised project management plan (DS-03)

    NASA Technical Reports Server (NTRS)

    Murphy, Diane R.

    1995-01-01

    The Project Plan is the governing document for the implementation of the Automated Procurement System (APS). It includes a description of the proposed system, describes the work to be done, establishes a schedule of deliverables, and discusses the major standards and procedures to be followed.

  8. 75 FR 75666 - Advanced Placement (AP) Test Fee Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-06

    ...: On September 1, 2010, we published in the Federal Register (75 FR 53681) a notice inviting... in the September 1, 2010 notice (75 FR 53682-53683). We encourage eligible applicants to submit their... Advanced Placement (AP) Test Fee Program AGENCY: Office of Elementary and Secondary Education...

  9. The New AP Chemistry Exam: Its Rationale, Content, and Scoring

    ERIC Educational Resources Information Center

    Price, Paul D.; Kugel, Roger W.

    2014-01-01

    The 2013-2014 academic year marks the rollout of the redesigned advanced placement (AP) chemistry course and exam. There have been many questions as to why the course was redesigned and how the new examination will differ from its legacy version. In this article we give a brief overview of the legacy course and examine why a redesign occurred in…

  10. APS undulator and wiggler sources: Monte-Carlo simulation

    SciTech Connect

    Xu, S.L.; Lai, B.; Viccaro, P.J.

    1992-02-01

    Standard insertion devices will be provided to each sector by the Advanced Photon Source. It is important to define the radiation characteristics of these general purpose devices. In this document,results of Monte-Carlo simulation are presented. These results, based on the SHADOW program, include the APS Undulator A (UA), Wiggler A (WA), and Wiggler B (WB).

  11. Fabrication of the APS Storage Ring radio frequency accelerating cavities

    SciTech Connect

    Primdahl, K.; Bridges, J.; DePaola, F.; Kustom, R.; Snee, D.

    1993-07-01

    Specification, heat treatment, strength, and fatigue life of the Advanced Photon Source (APS) Storage Ring 352-MHz radio frequency (RF) accelerating cavity copper is discussed. Heat transfer studies, including finite element analysis, and configuration of water cooling is described. Requirements for and techniques of machining are considered. Braze and electron beam joint designs are compared. Vacuum considerations during fabrication are discussed.

  12. ACTIVATION OF AP-1 IN UROTSA CELLS BY METHYLATED ARSENICALS

    EPA Science Inventory

    ACTIVATION OF AP-1 IN UROTSA CELLS BY METHYLATED TRIVALENT ARSENICALS. Z Drobna1, I Jaspers2, D J Thomas3 and M Styblo1. 1Department of Pediatrics; 2Center for Environmental Medicine and Lung Biology, University of North Carolina at Chapel Hill, NC, USA; 3US EPA, RTP, NC, USA.

  13. The AP Lever for Boosting Access, Success, and Equity

    ERIC Educational Resources Information Center

    Roegman, Rachel; Hatch, Thomas

    2016-01-01

    Four New Jersey school districts worked together to increase student achievement by applying a number of strategies focused on getting traditionally underrepresented students to take more AP courses. The districts are members of the New Jersey Network of Superintendents (NJNS), comprising 15 superintendents who work together to develop systemwide…

  14. Nuclear Reactor Safety--The APS Submits its Report

    ERIC Educational Resources Information Center

    Physics Today, 1975

    1975-01-01

    Presents the summary section of the American Physical Society (APS) report on the safety features of the light-water reactor, reviews the design, construction, and operation of a reactor and outlines the primary engineered safety features. Summarizes the major recommendations of the study group. (GS)

  15. Approximate entropy (ApEn) as a complexity measure

    NASA Astrophysics Data System (ADS)

    Pincus, Steve

    1995-03-01

    Approximate entropy (ApEn) is a recently developed statistic quantifying regularity and complexity, which appears to have potential application to a wide variety of relatively short (greater than 100 points) and noisy time-series data. The development of ApEn was motivated by data length constraints commonly encountered, e.g., in heart rate, EEG, and endocrine hormone secretion data sets. We describe ApEn implementation and interpretation, indicating its utility to distinguish correlated stochastic processes, and composite deterministic/ stochastic models. We discuss the key technical idea that motivates ApEn, that one need not fully reconstruct an attractor to discriminate in a statistically valid manner—marginal probability distributions often suffice for this purpose. Finally, we discuss why algorithms to compute, e.g., correlation dimension and the Kolmogorov-Sinai (KS) entropy, often work well for true dynamical systems, yet sometimes operationally confound for general models, with the aid of visual representations of reconstructed dynamics for two contrasting processes.

  16. New technique of machining high precision mirror surface press roller

    NASA Astrophysics Data System (ADS)

    Hongsen, Deng

    1991-03-01

    High precision mirror surface press roller machining technique of corrosion and grinding proof is one of the key techniques that the production enterprises as well as the machining and manufacturing of the following industries sought to resolve for a long time: plastics, papermaking, rubber, film, and chip production. In Oct. 1984, a new comprehensive machining technique of metal brush coating, grinding with abrasive belt, as well as buffing was used to conduct nearly 20 experiments. In Jan. 1985, a pair of middle convex high precision mirror surface press rollers was successfully machined. The technical process is described.

  17. Properties of Hot Pressed Titanium Alloy Powders for Cryogenic Applications.

    NASA Technical Reports Server (NTRS)

    Friedman, G. I.; Kazaroff, J. M.

    1970-01-01

    Evaluation of strength and toughness of hot-pressed titanium alloy powders at room and at cryogenic temperatures. The purpose was to determine how the mechanical properties of solid bodies formed from powder would compare with wrought specimens of the same size and with the same chemical analysis. It was found that of five titanium powder-making processes investigated, only the Rotating Electrode Process (REP) was capable of producing ELI-grade titanium alloy powder. Blocks hot-pressed from spherical REP powders had tensile properties equivalent to or better than those obtained from wrought bar.

  18. 25. Paper ready for the calender presses. This picture shows ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    25. Paper ready for the calender presses. This picture shows the paper after it has been coated and dried, as shown on page 238, and it being rolled at the end of the coating-machine. It is now ready to be sent to the big presses which calender it (or iron it, as popular pariance would have it). The pictures on pages 238 and 239 show a continuous process over a single machine; but on account of the length of teh machine, the process is illustrated in sections. (p.239.) - Champion-International Paper Company, West bank of Spicket River at Canal Street, Lawrence, Essex County, MA

  19. Canning Of Powdered Metal For Hot Isostatic Pressing

    NASA Technical Reports Server (NTRS)

    Juhas, John J.

    1989-01-01

    Quality of specimen enhanced by improved canning process. Method developed for canning specimens for hot isostatic pressing. Specimen placed inside refractory-metal ring, then sandwiched between two refractory-metal face sheets. Assembly placed inside die, then positioned in vacuum hot press. Heated to set temperature at prescribed vacuum to burn off all of binder in specimen. Advantages: powder-metallurgy composite totally purged of binder sealed in can in single operation, maintains size, shape, and uniformity of specimen. Weld region does not recrystallize, and little possibility of cracking.

  20. STS-26 Preflight Press Briefing: Crew Escape/Crew Equipment. Part 4 of 9

    NASA Technical Reports Server (NTRS)

    1988-01-01

    This NASA KSC video release presents part of a press conference held prior to Discovery flight STS-26, the first shuttle mission flown following the 51-L Challenger accident. The five member panel present individual viewgraph discussions followed by a question and answer period for the benefit of scientific journalists. William A. Chandler (Asst. to the Dir. of Engineering and the NSTS program) gives a brief overview of the crew escape system followed by Steven Nagel's (Astronaut) presentation on crew equipment. Robert Rice (Crew Escape System Manager) describes the flight test program and the innovative pyrotechnics system test program. Tim Pelischek (Pole Design Team) gives an assessment of the critical design review and Ricardo Machin reviews aerodynamic flight tests performed at Texas A&M and California. The second part of the video includes Robert Crippen's (Deputy Dir. of Operations, Kennedy Space Center) overview of NASA Management, the organizational changes and actions taken to meet the Roger's Commission recommendations.

  1. STS-26 Preflight Press Briefing: Shuttle Systems Changes (2). Part 3 of 9

    NASA Technical Reports Server (NTRS)

    1988-01-01

    This NASA KSC video release presents part of a press conference held prior to Discovery flight STS-26, the first shuttle mission flown following the 51-L Challenger accident. The video includes presentations by Gerald Smith (Solid Rocket Booster (SRB) Project Manager) and Joe Lombardo (Space Shuttle Main Engine (SSME) Project Manager) discussing the major changes that were made to the SRB and SSME between 51-L and STS-26. Mr. Smith's talk centered on the changes and redesigns made to the solid rocket motor field joint, the case to nozzle joint, the SRB aft skirt, and the ET aft attach ring. Mr. Lombardo discusses test data evaluation, SSME inspections and the SSME heat exchanger in particular.

  2. STS-26 Preflight Press Briefing: 5 Man Crew. Part 6 of 9

    NASA Technical Reports Server (NTRS)

    1988-01-01

    This NASA KSC video release presents part of a press conference held prior to Discovery flight STS-26, the first shuttle mission flown following the 51-L Challenger accident. The video opens with a statement from Commander Frederick H. Hauck, and the introductions of crew members, Richard O. Covey, Pilot, and mission specialists, John M. Lounge, George D. Nelson, and David C. Hilmers. Some of the questions posed by scientific journalists addressed the following subjects: launch preparation in the month prior to flight, astronaut family anxieties in light of the Challenger accident, extent of safety measures made prior to flight, flight readiness firing, the crew escape system, civilians in space, conservative mission design, astronaut selection, mission turnaround and launch rate, and the ability to maintain a high level of scrutiny regarding safety on future missions.

  3. Nucleolin binds specifically to an AP-1 DNA sequence and represses AP1-dependent transactivation of the matrix metalloproteinase-13 gene.

    PubMed

    Samuel, Shaija; Twizere, Jean-Claude; Beifuss, Katherine K; Bernstein, Lori R

    2008-01-01

    Transcriptional regulation via activator protein-1 (AP-1) protein binding to AP-1 binding sites within gene promoter regions of AP-1 target genes plays a key role in controlling cellular invasion, proliferation, and oncogenesis, and is important to pathogenesis of arthritis and cardiovascular disease. To identify new proteins that interact with the AP-1 DNA binding site, we performed the DNA affinity chromatography-based Nucleotide Affinity Preincubation Specificity TEst of Recognition (NAPSTER) assay, and discovered a 97 kDa protein that binds in vitro to a minimal AP-1 DNA sequence element. Mass spectrometric fragmentation sequencing determined that p97 is nucleolin. Immunoblotting of DNA affinity-purified material with anti-nucleolin antibodies confirmed this identification. Nucleolin also binds the AP-1 site in gel shift assays. Nucleolin interacts in NAPSTER with the AP-1 site within the promoter sequence of the metalloproteinase-13 gene (MMP-13), and binds in vivo in chromatin immunoprecipitation assays in the vicinity of the AP-1 site in the MMP-13 promoter. Overexpression of nucleolin in human HeLa cervical carcinoma cells significantly represses AP-1 dependent gene transactivation of a minimal AP-1 reporter construct and of an MMP-13 promoter reporter sequence. This is the first report of nucleolin binding and transregulation at the AP-1 site. PMID:17626252

  4. Aviation Safety Program: Weather Accident Prevention (WxAP) Development of WxAP System Architecture And Concepts of Operation

    NASA Technical Reports Server (NTRS)

    Grantier, David

    2003-01-01

    This paper presents viewgraphs on the development of the Weather Accident Prevention (WxAP) System architecture and Concept of Operation (CONOPS) activities. The topics include: 1) Background Information on System Architecture/CONOPS Activity; 2) Activity Work in Progress; and 3) Anticipated By-Products.

  5. Delayed simultaneous release mechanism

    NASA Technical Reports Server (NTRS)

    Moyer, X. W.; Webb, J. B. (Inventor)

    1973-01-01

    The disclosed appendage release mechanism is particularly adapted for use with spacecraft operating with despin mechanisms and releasable appendages. It includes a flexible loop and a number of appendage releasing devices which are attached to the flexible loop. The appendage releasing devices are made up of piston-cams and ball latches which hold the appendages as long as the flexible loop is maintained in a taut condition, but which release the appendages upon relaxation of the flexible loop. The flexible loop remains taut as long as the despin weights remain attached, but relaxes when the despin weights are released.

  6. NF-κB and AP-1 Connection: Mechanism of NF-κB-Dependent Regulation of AP-1 Activity

    PubMed Central

    Fujioka, Shuichi; Niu, Jiangong; Schmidt, Christian; Sclabas, Guido M.; Peng, Bailu; Uwagawa, Tadashi; Li, Zhongkui; Evans, Douglas B.; Abbruzzese, James L.; Chiao, Paul J.

    2004-01-01

    Nuclear factor κB (NF-κB) and activator protein 1 (AP-1) transcription factors regulate many important biological and pathological processes. Activation of NF-κB is regulated by the inducible phosphorylation of NF-κB inhibitor IκB by IκB kinase. In contrast, Fos, a key component of AP-1, is primarily transcriptionally regulated by serum responsive factors (SRFs) and ternary complex factors (TCFs). Despite these different regulatory mechanisms, there is an intriguing possibility that NF-κB and AP-1 may modulate each other, thus expanding the scope of these two rapidly inducible transcription factors. To determine whether NF-κB activity is involved in the regulation of fos expression in response to various stimuli, we analyzed activity of AP-1 and expression of fos, fosB, fra-1, fra-2, jun, junB, and junD, as well as AP-1 downstream target gene VEGF, using MDAPanc-28 and MDAPanc-28/IκBαM pancreatic tumor cells and wild-type, IKK1−/−, and IKK2−/− murine embryonic fibroblast cells. Our results show that elk-1, a member of TCFs, is one of the NF-κB downstream target genes. Inhibition of NF-κB activity greatly decreased expression of elk-1. Consequently, the reduced level of activated Elk-1 protein by extracellular signal-regulated kinase impeded constitutive, serum-, and superoxide-inducible c-fos expression. Thus, our study revealed a distinct and essential role of NF-κB in participating in the regulation of elk-1, c-fos, and VEGF expression. PMID:15314185

  7. The Press, the Government, and the Ethics Vacuum.

    ERIC Educational Resources Information Center

    Merrill, John C.

    Immanuel Kant's idea of a will to do the right thing--to be ethical--is essentially a dead concept with both press and government. The reasons for this "ethics vacuum" are two-fold: the foundations of ethics in both circles are vague, confusing, and beset by relativism and pragmatism so that no system of ethics ever really coalesces; and neither…

  8. The Press and California Higher Education. A Report.

    ERIC Educational Resources Information Center

    Chance, William

    This study examined the media coverage of California higher education in the popular press in four of the state's major dailies. In particular the study examined the roles that the San Francisco Chronicle, the Sacramento Bee, the Los Angeles Times, and the San Jose Mercury News play in fostering the public debate about higher education. All the…

  9. 42. PRESSING A SLAB OF CLAY ONTO A MOSAIC MOLD. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    42. PRESSING A SLAB OF CLAY ONTO A MOSAIC MOLD. THE MOLD, WHICH HAS A RAISED DESIGN, LEAVES AND OUTLINE IN THE SLAB, THE PIECES THUS DEFINED, ARE THEN CUT APART TO BE FIRED SEPARATELY AND REASSEMBLED. - Moravian Pottery & Tile Works, Southwest side of State Route 313 (Swamp Road), Northwest of East Court Street, Doylestown, Bucks County, PA

  10. PRESS SITE BECOMES INTERNATIONAL GATHERING SITE FOR MEDIA

    NASA Technical Reports Server (NTRS)

    1990-01-01

    The KSC press site becomes a busy international gathering site for the media during shuttle launch periods. Various activities are held in a number of facilities ranging in age. The news dome (shown during mission STS-41 pre-launch) was originally built as part of the 1976 Bicentennial.

  11. SOURCE ASSESSMENT: PRESSED AND BLOWN GLASS MANUFACTURING PLANTS

    EPA Science Inventory

    This report summarizes the results of a study to gather and analyze background information and technical data related to air emissions from glass manufacturers producing pressed and blown glassware. This includes all glassware except flat glass, glass containers, and fiber glass....

  12. The First Amendment, Schools and the Press: A Current Issue.

    ERIC Educational Resources Information Center

    Sasse, Mary

    While it is informative to trace the vicissitudes to which the First Amendment has been subjected since 1791, it is obvious that as far as schools are concerned, the courts have interpreted freedom of speech and the press in a limited way. For example, the courts have ruled that boards of education may remove books from school libraries on the…

  13. Argonne Director Eric Isaacs addresses the National Press Club

    ScienceCinema

    Eric Isaccs

    2010-01-08

    Argonne Director Eric Isaacs addresses the National Press Club on 9/15/2009. To build a national economy based on sustainable energy, the nation must first "reignite its innovation ecology," he said. Issacs makes the case for investing in science to secure America's future.

  14. The Press of the Soviet Union: A Bibliography.

    ERIC Educational Resources Information Center

    Bergethon, Bruce; And Others

    Compiled in response to the need for more information on the differences between the press systems of the United States and the Soviet Union, this bibliography contains 240 entries. Consisting of newspaper articles, journal articles, books, and pamphlets, the bibliography provides an overview of the different journalistic philosophies of the two…

  15. Quid Pro Quo: Tobacco Companies and the Black Press

    PubMed Central

    McCandless, Phyra M.; Yerger, Valerie B.

    2012-01-01

    Objectives. We explored the relationship between tobacco companies and the Black press, which plays an important role in conveying information and opinions to Black communities. Methods. In this archival case study, we analyzed data from internal tobacco industry documents and archives of the National Newspaper Publishers Association (NNPA), the trade association of the Black press. Results. In exchange for advertising dollars and other support, the tobacco industry expected and received support from Black newspapers for tobacco industry policy positions. Beginning in the 1990s, resistance from within the Black community and reduced advertising budgets created counterpressures. The tobacco industry, however, continued to sustain NNPA support. Conclusions. The quid pro quo between tobacco companies and the Black press violated journalistic standards and represented an unequal trade. Although numerous factors explain today's tobacco-related health disparities, the Black press's service to tobacco companies is problematic because of the trust that the community placed in such media. Understanding the relationship between the tobacco industry and the NNPA provides insight into strategies that the tobacco industry may use in other communities and countries. PMID:21852652

  16. DETAIL VIEW OF FILTER PRESS REMAINS, BOILER, SECONDARY ORE BIN, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    DETAIL VIEW OF FILTER PRESS REMAINS, BOILER, SECONDARY ORE BIN, TRAM TRESTLE AND WATER TANK, LOOKING NORTHWEST. HIS VIEW IS TAKEN FROM THE THIRD LEVEL OF THE MILL, NEARBY THE BLACKSMITH'S FORGE. - Keane Wonder Mine, Park Route 4 (Daylight Pass Cutoff), Death Valley Junction, Inyo County, CA

  17. 19. Interior detail, grinder and drill press, Machine Shop, Roundhouse ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. Interior detail, grinder and drill press, Machine Shop, Roundhouse Machine Shop Extension, Southern Pacific Railroad Carlin Shops, view to south (135mm lens). - Southern Pacific Railroad, Carlin Shops, Roundhouse Machine Shop Extension, Foot of Sixth Street, Carlin, Elko County, NV

  18. 18. Interior detail, drill press and grinder, Machine Shop, Roundhouse ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. Interior detail, drill press and grinder, Machine Shop, Roundhouse Machine Shop Extension, Southern Pacific Railroad Carlin Shops, view to east (135mm lens). - Southern Pacific Railroad, Carlin Shops, Roundhouse Machine Shop Extension, Foot of Sixth Street, Carlin, Elko County, NV

  19. Tell Us More: Reading Comprehension, Engagement, and Conceptual Press Discourse

    ERIC Educational Resources Information Center

    McElhone, Dot

    2012-01-01

    This study examines interactions between teachers and students during reading comprehension instruction to determine how certain patterns of teacher-student talk support student comprehension achievement and reading engagement. The central focus of the study is "conceptual press discourse," a pattern of teacher response that includes requests for…

  20. Looking north at uing press of the submerged arc weld ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Looking north at u-ing press of the submerged arc weld (saw) line of the main pipe mill building, bay 7. - U.S. Steel National Tube Works, Main Pipe Mill Building, Along Monongahela River, McKeesport, Allegheny County, PA

  1. 9. VIEW OF MOLTEN SALT BATH EQUIPMENT AND ROLLER PRESSES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. VIEW OF MOLTEN SALT BATH EQUIPMENT AND ROLLER PRESSES BEING INSTALLED ON THE WEST SIDE (SIDE B) OF BUILDING 883. SIDE B OF BUILDING 883 WAS USED TO PROCESS ENRICHED URANIUM FROM 1957-66. (1/23/57) - Rocky Flats Plant, Uranium Rolling & Forming Operations, Southeast section of plant, southeast quadrant of intersection of Central Avenue & Eighth Street, Golden, Jefferson County, CO

  2. Ethics and the Press: Readings in Mass Media Morality.

    ERIC Educational Resources Information Center

    Merrill, John C., Ed.; Barney, Ralph D., Ed.

    This collection of 35 articles addresses the topic of the ethical considerations and implications involved in reporting the news. Included in this book are such articles as: "Ethics and Journalism" by John Merrill, "Quality in Mass Communications" by Wilbur Schramm, "The American Press: Some Truths About Truths" by Edward Jay Epstein, "The New…

  3. Googling "Deaf": Deafness in the World's English-Language Press

    ERIC Educational Resources Information Center

    Power, Des

    2007-01-01

    An Internet search tool, Google Alert, was used to survey the global English-language press July-December 2005 for references to deaf people. The survey found that such references focus on people who are deaf rather than the disability itself, thus demonstrating how well deaf people fit into the mainstream. Derogatory terminology such as "deaf and…

  4. University Press Meeting Dominated by Donor Proposal and Digital Publishing

    ERIC Educational Resources Information Center

    Howard, Jennifer

    2007-01-01

    A surprise request for proposals from the Andrew W. Mellon Foundation and a forthcoming report on university publishing in the digital age were among topics discussed at the annual meeting of the Association of American University Presses. The offer from the Mellon Foundation concerns support for collaborative, monograph-centered projects in…

  5. Student Press Freedom: One View of the "Hazelwood" Decision.

    ERIC Educational Resources Information Center

    Goodman, Mark

    1988-01-01

    Reviews the "Hazelwood v. Kuhlmeier" U.S. Supreme Court decision upholding a principal's right to censor the content of a school-sponsored student publication. Explains why teachers oppose this decision, discusses liability issues, and argues for a free, uncensored student press. Includes eight legal references. (MLH)

  6. The Post-Revolutionary Portuguese Press: New Faces, Old Problems.

    ERIC Educational Resources Information Center

    Agee, Warren K.; Traquina, Nelson

    The Portuguese press is now guaranteed free access to official sources of information, professional confidentiality, freedom of publication and of competition, and the independence of the professional journalist; yet its ability to influence public opinion is limited by a traditional expectation of governmental repression and by present financial…

  7. A Community College District/University Press Copublishing Venture.

    ERIC Educational Resources Information Center

    Caraway, Georgia Kemp

    1994-01-01

    Describes cooperation between the Dallas County Community College District (DCCCD) and University of North Texas Press, resulting in the publication of a collection of short stories and a book of poetry written by DCCCD faculty and staff. Provides information on sales, marketing and promotion, classroom use of the books, and opportunities for…

  8. "...Establish the Student Press--And Stifle It!"

    ERIC Educational Resources Information Center

    McCallie, Franklin

    1990-01-01

    Presents an acceptance speech by Franklin McCallie, principal of Kirkwood High School (Missouri), for the "Administrator of the Year" award presented by the Missouri Interscholastic Press Association and the Missouri Journalism Education Association in April 1989. Discusses journalism's role in achieving the school's chief goals: student growth,…

  9. Toward a Normative Theory of Freedom of the Press.

    ERIC Educational Resources Information Center

    Jensen, Dwight Wm.

    In considering the possibility of a normative theory of freedom of the press, this paper examines arguments about such freedom in the Third World and elsewhere. Some of the arguments discussed in the paper are derived from the theories of John Locke and Karl Marx; others are drawn from the concepts of divine rights, elitism, liberal democracy, and…

  10. Extraction of proteins from pennycress seeds and press cake

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In order to more fully utilize pennycress, a potentially viable bio-diesel source, the proteinaceous components were extracted from pennycress seed and press cake. The amino acid composition of the proteins present in pennycress was typical for proteins derived from plants, with glycine, glutamic ac...

  11. Institutional Stress: Conflicting Normative Models in the Catholic Press.

    ERIC Educational Resources Information Center

    Thorn, William; Garrison, M. Bruce

    To determine whether the diocesan newspapers of the Catholic church are based on an autonomous, adversarial model or on an institutional, public relations model of the press, a survey was conducted of 148 editors and 145 bishops or publishers of such newspapers. Results showed that the editors and bishops agreed on the three major roles of the…

  12. Skylab 4 crewmen look over notes for press conference

    NASA Technical Reports Server (NTRS)

    1974-01-01

    The three crewmen of the third manned Skylab mission look over their notes for their upcoming post-mission press conference at JSC. They are, from left to right, Astronaut Gerald P. Carr, commander; Scientist-Astronaut Edward G. Gibson, science pilot; and Astronaut William R. Pogue, pilot. The three astronauts spent 84 days aboard the Skylab space station cluster in Earth orbit.

  13. The Mutilated Boy and the Press: A Rumor Study.

    ERIC Educational Resources Information Center

    Brown, Lee

    Responsible editors avoid printing falsehoods, but the public sometimes demands that rumors be covered in the press. One example of such rumors and the way editors deal with them is the "Mutilated Boy." The "Mutilated Boy" rumor has been circulating for decades and involves a brutal attack upon a small boy in a public rest room. The "crime" is…

  14. Pressing for Elaboration in Student Talk about Texts

    ERIC Educational Resources Information Center

    McElhone, D.

    2013-01-01

    This article explores the practice of one accomplished teacher who uses follow-up probes to press her fourth- and fifth-grade students to clarify and articulate their ideas more fully. Qualitative analysis of field notes, teacher and student interviews, and video recordings of instruction, and discourse analysis of reading conferences revealed…

  15. Inter Press Service: News from the Third World.

    ERIC Educational Resources Information Center

    Giffard, C. Anthony

    A content analysis was undertaken of the files for one month of the Rome-based Inter Press Service (IPS), an international news agency specializing in the news relating to the Third World. The data suggested that IPS is indeed providing a different kind of news service from that of the traditional news agencies. More than three-quarters of the…

  16. Argonne Director Eric Isaacs addresses the National Press Club

    SciTech Connect

    Eric Isaccs

    2009-09-17

    Argonne Director Eric Isaacs addresses the National Press Club on 9/15/2009. To build a national economy based on sustainable energy, the nation must first "reignite its innovation ecology," he said. Issacs makes the case for investing in science to secure America's future.

  17. TOXICS RELEASE INVENTORY (TRI)

    EPA Science Inventory

    The Toxics Release Inventory (TRI) site is designed to provide information on toxic chemical releases including collected data, guidance documents, program planning, background, history, and, program contacts, among other things. The data included in this homepage have been submi...

  18. Coverage of Jamaica in the U.S. and Canadian Press in 1976: A Study of Press Bias and Effect.

    ERIC Educational Resources Information Center

    Cuthbert, Marlene; Sparkes, Vernone

    In 1976, Jamaican government officals claimed that their island had received an especially negative press in the United States during 1975 and 1976 with serious consequences for the economy and tourist trade. This accusation was not made about Canadian coverage, with one major exception, and Canadian tourism to Jamaica increased during those years…

  19. Metonymie dans la presse ecrite: entre discours et langue (Metonymies in the Press: Between Discourse and Language).

    ERIC Educational Resources Information Center

    Lecolle, Michelle

    2001-01-01

    This paper describes certain metonymies that are often employed in the daily French press. In such metonymies, a human being or a set of individuals are referred to by means of the name of an institutional location (i.e., a capital city, a ministry in a western country, the name of a country). These metonymic patterns do not seem to be used by…

  20. Airborne Precision Spacing (APS) Dependent Parallel Arrivals (DPA)

    NASA Technical Reports Server (NTRS)

    Smith, Colin L.

    2012-01-01

    The Airborne Precision Spacing (APS) team at the NASA Langley Research Center (LaRC) has been developing a concept of operations to extend the current APS concept to support dependent approaches to parallel or converging runways along with the required pilot and controller procedures and pilot interfaces. A staggered operations capability for the Airborne Spacing for Terminal Arrival Routes (ASTAR) tool was developed and designated as ASTAR10. ASTAR10 has reached a sufficient level of maturity to be validated and tested through a fast-time simulation. The purpose of the experiment was to identify and resolve any remaining issues in the ASTAR10 algorithm, as well as put the concept of operations through a practical test.

  1. The APS booster synchrotron: Commissioning and operational experience

    SciTech Connect

    Milton, S.V.

    1995-07-01

    The Advanced Photon Source (APS) at Argonne National Laboratory (ANL) was constructed to provide a large user community with intense and high brightness synchrotron radiation at x-ray wavelengths. A 7-GeV positron beam is used to generate this light. Acceleration of the beam from 450 MeV to 7 GeV is accomplished at a 2-Hz repetition rate by the booster synchrotron. Commissioning of the booster began in the second quarter of 1994 and continued on into early 1995. The booster is now routinely used to provide beam for the commissioning of the APS storage ring. Reported here are our commissioning and operational experiences with the booster synchrotron.

  2. Tank 241-AP-107 tank characterization plan. Revision 1

    SciTech Connect

    Schreiber, R.D.

    1995-01-20

    Defense Nuclear Facilities Safety Board has directed the DOE to concentrate ear-term sampling and analysis activities on identification and resolution of issues (Conway 1993). The Data Quality Objective (DQO) process was chosen as a tool to be used in the resolution of safety issues. As a result, a revision in the Federal Facilities Agreement and Consent Order (Tri-Party Agreement) milestone M-44-00 has been made, which states that ``A Tank Characterization Plan (TCP) will be developed for each double-shell tank (DST) and single-shell tank (SST) using the DQO process; Development of TCPs by the DQO process is intended to allow users (e.g., Hanford Facility user groups, regulators) to ensure their needs will be met and that resources are devoted to gaining only necessary information.`` This document satisfies that requirement for the tank 241-AP-107 (AP-107).

  3. Introduction to Physics of the Universe in AP Physics Classrooms

    NASA Astrophysics Data System (ADS)

    Allen, Stephanie L.

    2006-12-01

    Often students have difficulty understanding the connections that must be made between old and new concepts. This curriculum is designed to lead AP Physics students through this process with gamma ray bursts. Students will participate in various discussions, demonstrations, exercises and activities that lead them through universe basics, life cycles of stars, black holes, the electromagnetic spectrum, and they will learn about various NASA observatories. Ultimately, this will result in a better understanding of how astrophysicists have come to understand the gamma ray burst. This series of lessons was created for the three to four weeks after the AP Physics exam. The curriculum was developed through gathering resources from various scientific organizations, developing new ideas and speaking with scientists at NASA Goddard Space Flight Center. The result is a manual of lesson plans, activities and answer keys for teachers to use in their own classrooms.

  4. Status of APS 1-Mwe Parabolic Trough Project

    SciTech Connect

    Canada, S.; Brosseau, D.; Kolb, G.; Moore, L.; Cable, R.; Price, H.

    2005-11-01

    Arizona Public Service (APS) is currently installing new power facilities to generate a portion of its electricity from solar resources that will satisfy its obligation under the Arizona Environmental Portfolio Standard (EPS). During FY04, APS began construction on a 1-MWe parabolic trough concentrating solar power plant. This plant represents the first parabolic trough plant to begin construction since 1991. Site preparation and construction activities continued throughout much of FY05, and startup activities are planned for Fall 2005 (with completion early in FY06). The plant will be the first commercial deployment of the Solargenix parabolic trough collector technology developed under contract to the National Renewable Energy Laboratory. The plant will use an organic Rankine cycle (ORC) power plant, provided by Ormat. The ORC power plant is much simpler than the conventional steam Rankine cycle plant and allows unattended operation of the facility.

  5. Variability of Balmer Profiles in Magnetic Ap/Bp Stars

    NASA Astrophysics Data System (ADS)

    Valyavin, G.; Lee, B.-C.; Shulyak, D.; Han, I.; Kochukhov, O.; Khang, D.-I.; Kim, K.-M.

    2007-06-01

    A set of high precision measurements of weak variations of hydrogen lines in spectra of seven magnetic Ap/Bp stars was carried out using the BOES echelle spectrograph of the Bohuynsan Optical Astronomy Observatory (South Korea). A weak (1-2 %) periodic variability of the Balmer line wings has been detected in the spectra of 2 program stars. Upper limits of possible variations are presented for the remaining 5 objects. We discuss the discovered variability in the framework of model atmospheres with magnetic force terms included. The periodic changes in the Balmer profiles are caused by perturbations in atmospheres of Ap/Bp stars due to their rotationally modulated non-force-free magnetic fields.

  6. Measurements of ground motion and magnet vibrations at the APS

    SciTech Connect

    Shiltsev, V.

    1996-09-01

    This article presents results of ground motion and magnet vibrations measurements at the Advanced Photon Source. The experiments were done over a wide, frequency range (0-05-100 Hz) with the use of SM-3KV-type seismic probes from the Budker Institute of Nuclear Physics (Russia). Spectral power densities of vertical and horizontal motions of the APS hall floor and quadrupoles on regular supports were obtained. Also investigated were magnet vibrations induced by designed cooling water flow and spectral characteristics of spatial correlation of the quadrupole vibrations at different sectors of the ring. The influence of personnel activity in the hall and traffic under the ring on the slow motion of storage ring elements were observed. Amplitudes of vibrations at the APS are compared with results of seismic measurements at some other accelerators.

  7. QCD on the highly parallel computer AP1000

    NASA Astrophysics Data System (ADS)

    Akemi, K.; de Forcrand, Ph.; Fujisaki, M.; Hashimoto, T.; Hege, H. C.; Hioki, S.; Makino, J.; Miyamura, O.; Nakamura, A.; Okuda, M.; Stamatescu, I. O.; Tago, Y.; Takaishi, T.; QCD TARO (QCD on Thousand cell ARray processorsOmnipurpose) Collaboration

    We have been running quenched QCD simulations on 32 4 and 32 3 × 48 lattices using a 512 processor AP1000, which is a highly parallel computer with up to 1024 processing elements. We have developed programs for update, blocking and hadron propagator calculations. The pseudo heatbath and the overrelaxation algorithms were used for the update with performance of 2.6 and 2.0 μsec/link, respectively.

  8. Thrombin induces endothelial arginase through AP-1 activation.

    PubMed

    Zhu, Weifei; Chandrasekharan, Unni M; Bandyopadhyay, Smarajit; Morris, Sidney M; DiCorleto, Paul E; Kashyap, Vikram S

    2010-04-01

    Arterial thrombosis is a common disease leading to severe ischemia beyond the obstructing thrombus. Additionally, endothelial dysfunction at the site of thrombosis can be rescued by l-arginine supplementation or arginase blockade in several animal models. Exposure of rat aortic endothelial cells (RAECs) to thrombin upregulates arginase I mRNA and protein levels. In this study, we further investigated the molecular mechanism of thrombin-induced arginase changes in endothelial cells. Thrombin strikingly increased arginase I promoter and enzyme activity in primary cultured RAECs. Using different deletion and point mutations of the promoter, we demonstrated that the activating protein-1 (AP-1) consensus site located at -3,157 bp in the arginase I promoter was a thrombin-responsive element. Electrophoretic mobility shift assay and chromatin immunoprecipitation assay further confirmed that upon thrombin stimulation, c-Jun and activating transcription factor-2 (ATF-2) bound to the AP-1 site, which initiated the transactivation. Moreover, loss-of-function studies using small interfering RNA confirmed that recruitment of these two transcription factors to the AP-1 site was required for thrombin-induced arginase upregulation. In the course of defining the signaling pathway leading to the activation of AP-1 by thrombin, we found thrombin-induced phosphorylation of stress-activated protein kinase/c-Jun-NH(2)-terminal kinase (SAPK/JNK or JNK1/2/3) and p38 mitogen-activated protein kinase, which were followed by the phosphorylation of both c-Jun and ATF-2. These findings reveal the basis for thrombin induction of endothelial arginase I and indicate that arginase inhibition may be an attractive therapeutic alternative in the setting of arterial thrombosis and its associated endothelial dysfunction. PMID:20032511

  9. Diffusion and Settling in Ap/Bp Stars

    SciTech Connect

    Turcotte, S

    2003-04-09

    Ap/Bp stars are magnetic chemically peculiar early A and late B type stars of the main sequence. They exhibit peculiar surface abundance anomalies that are thought to be the result of gravitational settling and radiative levitation. The physics of diffusion in these stars are reviewed briefly and some model predictions are discussed. While models reproduce some observations reasonably well, more work is needed before the behavior of diffusing elements in a complex magnetic field is fully understood.

  10. Architecture of the APS real-time orbit feedback system.

    SciTech Connect

    Carwardine, J. A.; Lenkszus, F. R.

    1997-11-21

    The APS Real-Time Orbit Feedback System is designed to stabilize the orbit of the stored positron beam against low-frequency sources such as mechanical vibration and power supply ripple. A distributed array of digital signal processors is used to measure the orbit and compute corrections at a 1kHz rate. The system also provides extensive beam diagnostic tools. This paper describes the architectural aspects of the system and describes how the orbit correction algorithms are implemented.

  11. Margin Assessment of AP1000 Loss of Flow Transient

    SciTech Connect

    Carlin, Edward L.; Hilton, Peter A.; Yixing Sung

    2006-07-01

    The Reactor Coolant System (RCS) of the AP1000 plant consists of two circulating loops. Each loop contains two canned motor Reactor Coolant (RC) pumps that have a rotating inertia to provide RCS flow coast-down if power to the pumps is lost. Westinghouse analysis of the complete loss of flow (CLOF) accident in support of the AP1000 design certification was based on the USNRC-approved traditional methodology applied to operating plants. The RCS response during the transient was predicted using the LOFTRAN code based on a reactivity insertion curve highly skewed to the bottom of the reactor core, but the calculation of Departure from Nucleate Boiling Ratio (DNBR) was performed assuming a top-skewed axial power profile. A more realistic margin assessment can be made by using an improved method similar to Westinghouse RAVE methodology recently approved by the USNRC. The improved method uses the three-dimensional kinetic nodal code SPNOVA coupled with the reactor core thermal-hydraulic code VIPRE-W for predicting the reactor core response during the CLOF transient. The improved method significantly improves margin predictions by generating core power distributions consistent with the trip reactivity changes for the DNBR calculation. The margin assessment showed that the improved method resulted in a 19% DNBR increase as compared to the traditional method for the AP1000 CLOF transient. (authors)

  12. Discoveries in the Atmospheres of roAp Stars

    NASA Astrophysics Data System (ADS)

    Kurtz, D. W.; Freyhammer, L. M.; Elkin, V. G.; Mathys, G.

    2007-11-01

    We have obtained a large amount of data on over 40 roAp stars and potential roAp stars with the Ultraviolet and Visual Echelle Spectrograph (UVES) on the VLT with time resolution typically around 1 min and radial velocity precision as high as 1 m s-1. Abundance stratification caused by atomic diffusion in the presence of strong global magnetic fields gives promise of three-dimensional maps of the pulsation amplitude and phase, and of the abundance distributions of many ions that may provide the strongest observational tests of atomic diffusion theory. Studies of individual spectral lines and of line profile variability sample the observable atmospheres of roAp stars from continuum optical depth τ5000~1 to as high as τ5000~10-5, revealing fascinating new pulsational behaviour not observed in other types of pulsating stars, including, inter alia, line profile variability in rare earth elements lines interpreted by as evidence for shock waves in the high atmosphere of these stars, an intriguing range of line bisector shapes, and a new pulsational diagnostic for resolved Zeeman components for the most strongly magnetic stars.

  13. A Semi-automated Abundance Survey of Ap Stars

    NASA Astrophysics Data System (ADS)

    Hall, Martin P.; Kurtz, Don; Elkin, Vladimir; Bruntt, Hans

    2015-08-01

    We have carried out an abundance analysis on the high-resolution spectra of approximately 350 Ap stars collected between 2007 and 2010 on the FEROS Echelle (Fibre-led, Extended Range, Echelle ) spectrograph housed at the 2.2-m telescope at European Southern Observatory at La Silla, Chile. We employed the VWA package (vsin I, wavelength shift, abundance analysis) for preliminary selection of spectral lines, and a semi-automated set of routines which we developed in the programming language IDL, to calculate the equivalent widths and abundances of ions of Iron and the rare earth elements Neodymium and Praseodymium using the WIDTH program and NEMO model atmospheres. Initial results are presented, which reinforce the correlation between iron abundance and effective temperature, from an over-abundance in the late Bp stars, to under-abundant in the early F stars. Results also suggest that the disequilibrium in abundances of the first and second ionisation stages of these ions in the rapidly oscillating Ap (roAp) stars may a consequence of the relatively cool temperatures of those stars, rather than a signature of pulsation.

  14. Maternal AP determinants in the Drosophila oocyte and embryo.

    PubMed

    Ma, Jun; He, Feng; Xie, Gengqiang; Deng, Wu-Min

    2016-09-01

    An animal embryo cannot initiate its journey of forming a new life on its own. It must rely on maternally provided resources and inputs to kick-start its developmental process. In Drosophila, the initial polarities of the embryo along both the anterior-posterior (AP) and dorsal-ventral (DV) axes are also specified by maternal determinants. Over the past several decades, genetic and molecular studies have identified and characterized such determinants, as well as the zygotic genetic regulatory networks that control patterning in the early embryo. Extensive studies of oogenesis have also led to a detailed knowledge of the cellular and molecular interactions that control the formation of a mature egg. Despite these efforts, oogenesis and embryogenesis have been studied largely as separate problems, except for qualitative aspects with regard to maternal regulation of the asymmetric localization of maternal determinants. Can oogenesis and embryogenesis be viewed from a unified perspective at a quantitative level, and can that improve our understanding of how robust embryonic patterning is achieved? Here, we discuss the basic knowledge of the regulatory mechanisms controlling oogenesis and embryonic patterning along the AP axis. We explore properties of the maternal Bicoid gradient in relation to embryo size in search for a unified framework for robust AP patterning. WIREs Dev Biol 2016, 5:562-581. doi: 10.1002/wdev.235 For further resources related to this article, please visit the WIREs website. PMID:27253156

  15. Oxidative Stress Induced Ventricular Arrhythmia and Impairment of Cardiac Function in Nos1ap Deleted Mice.

    PubMed

    Sugiyama, Koji; Sasano, Tetsuo; Kurokawa, Junko; Takahashi, Kentaro; Okamura, Tadashi; Kato, Norihiro; Isobe, Mitsuaki; Furukawa, Tetsushi

    2016-05-25

    Genome-wide association study has identified that the genetic variations at NOS1AP (neuronal nitric oxide synthase-1 adaptor protein) were associated with QT interval and sudden cardiac death (SCD). However, the mechanism linking a genetic variant of NOS1AP and SCD is poorly understood. We used Nos1ap knockout mice (Nos1ap(-/-)) to determine the involvement of Nos1ap in SCD, paying special attention to oxidative stress.At baseline, a surface electrocardiogram (ECG) and ultrasound echocardiography (UCG) showed no difference between Nos1ap(-/-) and wild-type (WT) mice. Oxidative stress was induced by a single injection of doxorubicin (Dox, 25 mg/kg). After Dox injection, Nos1ap(-/-) showed significantly higher mortality than WT (93.3 versus 16.0% at day 14, P < 0.01). ECG showed significantly longer QTc in Nos1ap(-/-) than WT, and UCG revealed significant reduction of fractional shortening (%FS) only in Nos1ap(-/-) after Dox injection. Spontaneous ventricular tachyarrhythmias were documented by telemetry recording after Dox injection only in Nos1ap(-/-). Ex vivo optical mapping revealed that the action potential duration (APD)90 was prolonged at baseline in Nos1ap(-/-), and administration of Dox lengthened APD90 more in Nos1ap(-/-) than in WT. The expression of Bnp and the H2O2 level were higher in Nos1ap(-/-) after Dox injection. Nos1ap(-/-) showed a reduced amplitude of calcium transient in isolated cardiomyocytes after Dox injection. Administration of the antioxidant N-acetyl-L-cysteine significantly reduced mortality of Nos1ap(-/-) by Dox injection, accompanied by prevention of QT prolongation and a reduction in %FS.Although Nos1ap(-/-) mice have apparently normal hearts, oxidative stress evokes ventricular tachyarrhythmia and heart failure, which may cause sudden cardiac death. PMID:27170476

  16. Fungi in the Ancient World: How Mushrooms, Mildews, Molds and Yeast Shaped the Early Civilizations of Europe, the Mediterranean, and the Near East. APS Press, St. Paul, MN.

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This monograph comprises a survey of roles of fungi in ancient societies of the western tradition or its predecessors in Egypt and western Asia. Topics include the use of yeasts in brewing and baking, poisonous and mycotoxigenic fungi, fungi used for medicinal purposes or for other technologies, pla...

  17. Nerve-released acetylcholine contracts urinary bladder smooth muscle by inducing action potentials independently of IP3-mediated calcium release.

    PubMed

    Nausch, Bernhard; Heppner, Thomas J; Nelson, Mark T

    2010-09-01

    Nerve-released ACh is the main stimulus for contraction of urinary bladder smooth muscle (UBSM). Here, the mechanisms by which ACh contracts UBSM are explored by determining Ca(2+) and electrical signals induced by nerve-released ACh. Photolysis of caged inositol 1,4,5-trisphosphate (IP(3)) evoked Ca(2+) release from the sarcoplasmic reticulum. Electrical field stimulation (20 Hz) induced Ca(2+) waves within the smooth muscle that were present only during stimulus application. Ca(2+) waves were blocked by inhibition of muscarinic ACh receptors (mAChRs) with atropine and depletion of sarcoplasmic reticulum Ca(2+) stores with cyclopiazonic acid (CPA), and therefore likely reflect activation of IP(3) receptors (IP(3)Rs). Electrical field stimulation also increased excitability to induce action potentials (APs) that were accompanied by Ca(2+) flashes, reflecting Ca(2+) entry through voltage-dependent Ca(2+) channels (VDCCs) during the action potential. The evoked Ca(2+) flashes and APs occurred as a burst with a lag time of approximately 1.5 s after onset of stimulation. They were not inhibited by blocking IP(3)-mediated Ca(2+) waves, but by blockers of mAChRs (atropine) and VDCCs (diltiazem). Nerve-evoked contractions of UBSM strips were greatly reduced by blocking VDCCs, but not by preventing IP(3)-mediated Ca(2+) signaling with cyclopiazonic acid or inhibition of PLC with U73122. These results indicate that ACh released from nerve varicosities induces IP(3)-mediated Ca(2+) waves during stimulation; but contrary to expectations, these signals do not appear to participate in contraction. In addition, our data provide compelling evidence that UBSM contractions evoked by nerve-released ACh depend on increased excitability and the resultant Ca(2+) entry through VDCCs during APs. PMID:20573989

  18. The New York State Program for the Conservation and Preservation of Library Research Materials. Selected Press Clippings about Projects Funded by the Discretionary Grant Program, 1988/89 and 1989/90.

    ERIC Educational Resources Information Center

    New York State Library, Albany. Div. of Library Development.

    This document is composed of clippings from news publications and press releases about projects funded by the New York State Discretionary Grant Program for Conservation and Preservation of Library Research Materials, which annually awards $500,000 to libraries, archives, historical societies, and similar agencies in New York State through…

  19. Functional Authentication of a Novel Gastropod Gonadotropin-Releasing Hormone Receptor Reveals Unusual Features and Evolutionary Insight.

    PubMed

    Kavanaugh, Scott I; Tsai, Pei-San

    2016-01-01

    A gonadotropin-releasing hormone (GnRH)-like molecule was previously identified in a gastropod, Aplysia californica, and named ap-GnRH. In this study, we cloned the full-length cDNA of a putative ap-GnRH receptor (ap-GnRHR) and functionally authenticated this receptor as a bona fide ap-GnRHR. This receptor contains two potential translation start sites, each accompanied by a Kozak sequence, suggesting the translation of a long and a short form of the receptor is possible. The putative ap-GnRHR maintains the conserved structural motifs of GnRHR-like receptors and shares 45% sequence identity with the octopus GnRHR. The expression of the putative ap-GnRHR short form is ubiquitous in all tissues examined, whereas the long form is only expressed in parts of the central nervous system, osphradium, small hermaphroditic duct, and ovotestis. The cDNA encoding the long or the short receptor was transfected into the Drosophila S2 cell line and subject to a radioreceptor assay using 125I-labeled ap-GnRH as the radioligand. Further, the transfected cells were treated with various concentrations of ap-GnRH and measured for the accumulation of cAMP and inositol monophosphate (IP1). Radioreceptor assay revealed that only the long receptor bound specifically to the radioligand. Further, only the long receptor responded to ap-GnRH with an increased accumulation of IP1, but not cAMP. Our studies show that despite the more prevalent expression of the short receptor, only the long receptor is the functional ap-GnRHR. Importantly, this is only the second report on the authentication of a protostome GnRHR, and based on the function and the phylogenetic grouping of ap-GnRHR, we suggest that this receptor is more similar to protostome corazonin receptors than chordate GnRHRs. PMID:27467252

  20. Functional Authentication of a Novel Gastropod Gonadotropin-Releasing Hormone Receptor Reveals Unusual Features and Evolutionary Insight

    PubMed Central

    Kavanaugh, Scott I.

    2016-01-01

    A gonadotropin-releasing hormone (GnRH)-like molecule was previously identified in a gastropod, Aplysia californica, and named ap-GnRH. In this study, we cloned the full-length cDNA of a putative ap-GnRH receptor (ap-GnRHR) and functionally authenticated this receptor as a bona fide ap-GnRHR. This receptor contains two potential translation start sites, each accompanied by a Kozak sequence, suggesting the translation of a long and a short form of the receptor is possible. The putative ap-GnRHR maintains the conserved structural motifs of GnRHR-like receptors and shares 45% sequence identity with the octopus GnRHR. The expression of the putative ap-GnRHR short form is ubiquitous in all tissues examined, whereas the long form is only expressed in parts of the central nervous system, osphradium, small hermaphroditic duct, and ovotestis. The cDNA encoding the long or the short receptor was transfected into the Drosophila S2 cell line and subject to a radioreceptor assay using 125I-labeled ap-GnRH as the radioligand. Further, the transfected cells were treated with various concentrations of ap-GnRH and measured for the accumulation of cAMP and inositol monophosphate (IP1). Radioreceptor assay revealed that only the long receptor bound specifically to the radioligand. Further, only the long receptor responded to ap-GnRH with an increased accumulation of IP1, but not cAMP. Our studies show that despite the more prevalent expression of the short receptor, only the long receptor is the functional ap-GnRHR. Importantly, this is only the second report on the authentication of a protostome GnRHR, and based on the function and the phylogenetic grouping of ap-GnRHR, we suggest that this receptor is more similar to protostome corazonin receptors than chordate GnRHRs. PMID:27467252