These are representative sample records from Science.gov related to your search topic.
For comprehensive and current results, perform a real-time search at Science.gov.
1

Public Relations Press Release  

E-print Network

Public Relations Department Page 1/2 Press Release Black Death Bacterium Identified Genetic at least 600 years. Tübingen, 30.08.2011 The Black Death claimed the lives of one-third of Europeans: Y. pestis confirmed in victims of the Black Death via high-throughput se- quencing of the pPCP1

Lubich, Christian

2

PRESS RELEASE FROM NEUROPSYCHOPHARMACOLOGY  

E-print Network

TO http://www.nature.com/npp Nature and nurture separately influence dopamine activity DOI: 10.1038/nppPRESS RELEASE FROM NEUROPSYCHOPHARMACOLOGY (http://www.nature.com/npp) For a paper. Its use is granted only for journalists and news media receiving it directly from the Nature

Cai, Long

3

Public Relations Press Release  

E-print Network

Public Relations Department Page 1/3 Press Release Ice Age paintings from the Swabian Jura have also been recovered. Although Ice Age cave paintings are well documented in western Europe Alb (Painted rocks: The end of the Ice Age art of the Swabian Jura). The exhibit runs from November 10

Lubich, Christian

4

PRESS RELEASE FROM TRANSLATIONAL PSYCHIATRY  

E-print Network

PRESS RELEASE FROM TRANSLATIONAL PSYCHIATRY (http://www.nature.com/tp/) This press release is copyrighted to the journal Translational Psychiatry Its use is granted only for journalists and news media: While we are happy for images from Translational Psychiatry to be reproduced for the purposes

Cai, Long

5

PRESS RELEASE FROM MOLECULAR PSYCHIATRY  

E-print Network

PRESS RELEASE FROM MOLECULAR PSYCHIATRY (http://www.nature.com/mp) For a paper that will be published online on 09 August 2011 This press release is copyrighted to the journal Molecular Psychiatry of 1934. PICTURES: While we are happy for images from Molecular Psychiatry to be reproduced

Cai, Long

6

PRESS RELEASE FROM TRANSLATIONAL PSYCHIATRY  

E-print Network

PRESS RELEASE FROM TRANSLATIONAL PSYCHIATRY (http://www.nature.com/tp/) This press release is copyrighted to the journal Translational Psychiatry Its use is granted only for journalists and news media of 1934. PICTURES: While we are happy for images from Translational Psychiatry to be reproduced

Cai, Long

7

PRESS RELEASE FROM MOLECULAR PSYCHIATRY  

E-print Network

PRESS RELEASE FROM MOLECULAR PSYCHIATRY (http://www.nature.com/mp) For papers that will be published online on 30 August 2011 This press release is copyrighted to the journal Molecular Psychiatry Exchange Act of 1934. PICTURES: While we are happy for images from Molecular Psychiatry to be reproduced

Cai, Long

8

PRESS RELEASE FROM TRANSLATIONAL PSYCHIATRY  

E-print Network

PRESS RELEASE FROM TRANSLATIONAL PSYCHIATRY (http://www.nature.com/tp/) This press release is copyrighted to the journal Translational Psychiatry Its use is granted only for journalists and news media Translational Psychiatry to be reproduced for the purposes of contemporaneous news reporting, you must also seek

Cai, Long

9

PRESS RELEASE FROM MOLECULAR PSYCHIATRY  

E-print Network

PRESS RELEASE FROM MOLECULAR PSYCHIATRY (http://www.nature.com/mp) For papers that will be published online on 21 February 2012 This press release is copyrighted to the journal Molecular Psychiatry Exchange Act of 1934. PICTURES: While we are happy for images from Molecular Psychiatry to be reproduced

Cai, Long

10

Press Release Corporate Communications  

E-print Network

reducing drug dosages in the future. Drugs do not exhibit their effects until they have been taken up lags until drugs begin to exhibit their effects might be drastically reduced. For example, the tiny.ch@pvw.tu-darmstadt.de www.tu-darmstadt.de/presse presse@tu-darmstadt.de New Substances Accelerate Drug Transport Into Cells

Reggelin, Michael

11

PRESS RELEASE FROM NEUROPSYCHOPHARMACOLOGY  

E-print Network

likelihood of drug addiction A PDF of the paper mentioned on this release can be found in the Academic after childbirth. Little is currently known about its causes. Jean-Michel Le Melledo and colleagues

Cai, Long

12

PRESS RELEASE FROM TRANSLATIONAL PSYCHIATRY  

E-print Network

PRESS RELEASE FROM TRANSLATIONAL PSYCHIATRY (http://www.nature.com/tp/) For papers Psychiatry Its use is granted only for journalists and news media receiving it directly from the Nature Psychiatry to be reproduced for the purposes of contemporaneous news reporting, you must also seek permission

Cai, Long

13

CSR Press Release Submitted by  

E-print Network

commit to buy yogurt from cows not treated with rBGH Compass Group, North America Health & Wellness, FairCSR Press Release Submitted by: Categories: Posted: Another Victory for the Sustainable Food 'Moo-vement' In their efforts to serve healthier, more sustainable food, Bon Appetit Management Company and Compass Group USA

14

MAX PLANCK SOCIETY Press Release  

E-print Network

MAX PLANCK SOCIETY Press Release SP / 2004 (1) January 15th, 2004 Max Planck Society at the American Astronomical Society meeting in Atlanta, Georgia. Dr. Eric F. Bell of the Max-Planck consortium and led by Dr. Hans-Walter Rix, Director of the Max-Planck-Institute for Astronomy, said the image

15

How to write a press release  

NSDL National Science Digital Library

This project teaches Snow College students how to write a press release Writing a press release can be the most important skill an public releations pro cna master. Being able to write an effective press release will make you much more employable than your classmates and will help you land that big first job. Following the completion of this tutorial, students will be ...

Dart, Greg

2007-10-19

16

PRESS RELEASE FROM NEUROPSYCHOPHARMACOLOGY  

E-print Network

of an alcoholic drink induces striatal dopamine release in the human brain, and that the magnitude of this effect is related to familial alcoholism. The findings suggest a possible brain mechanism of inherited alcoholism, PLEASE CARRY A HYPERLINK TO http://www.nature.com/npp A taste for alcohol DOI: 10.1038/npp.2013

Cai, Long

17

Joint Press Release TWELFTH ITER NEGOTIATION MEETING  

E-print Network

Joint Press Release TWELFTH ITER NEGOTIATION MEETING Jeju, Korea, 6 December th 2005 Delegations on an Agreement on the joint implementation of the ITER international fusion energy project. This was the first/6/05 1:21 PMDraft Joint News Release Page 1 of 2http://www.iter.org/N_12_Joint_Press_Release.htm #12

18

Member News Nano News Press Releases  

E-print Network

NanoNEWS Member News Nano News Press Releases Nano Global News Nano Reports Nano Conferences", Exploring Matter with Synchrotron Light" and "Exploring Matter with Neutrons" by ordering from here. Nano. Send your Press R Judith.LightFeather@TNTG.org 14 Oct 2006 Researchers develop bistable nano switch

Espinosa, Horacio D.

19

Press Release Images for Spirit and Opportunity  

NSDL National Science Digital Library

This NASA website provides links to press release images, maps, and graphics with extensive captions of the "Spirit" and "Opportunity" Rover missions. Downloads of images and graphics at various resolutions are also available here. Images are catalogued separately by release date for both Spirit and Opportunity.

Laboratory, Nasa'S J.; Administration, National A.

20

CALIFORNIA POSTSECONDARY EDUCATION COMMISSION PRESS RELEASE  

E-print Network

CALIFORNIA POSTSECONDARY EDUCATION COMMISSION PRESS RELEASE Contact: Linda White California Postsecondary Education Commission 1303 J Street, Suite 500 Sacramento, California 95814-2938 (916) 322-7984 lwhite@cpec.ca.gov Commission Awards $1,889,657 Grant to California State University Fullerton to Improve

de Lijser, Peter

21

Paris, April 23, 2013 Press release  

E-print Network

collected from other oceans since 2009 during theTara Oceans expedition. - Study of plastic pollution, mercury and air pollutants in the Arctic by KAUST and OMP/IFREMER for mercury. - Study of ocean "color Paris, April 23, 2013 Press release Tara Oceans Polar Circle: a new scientific expedition

van Tiggelen, Bart

22

Press Release: Smithsonian Book News  

E-print Network

anthropological subjects such as forensic anthropology, human evolution, and archaeology. Each essay builds.Ruth@nmnh.si.edu FOR IMMEDIATE RELEASE ANTHROPOLOGY EXPLORED: NEW EDITION FEATURES MORE ESSAYS, INSTRUCTOR'S GUIDE Washington, D.C. ­ August 16, 2004 ­ Smithsonian Books announces the publication of the second edition of Anthropology

Mathis, Wayne N.

23

PRESS RELEASE FROM TRANSLATIONAL PSYCHIATRY  

E-print Network

to Alzheimer's disease DOI: 10.1038/tp.2011.55 Alzheimer's disease (AD) may be preceded by a molecular and accept the embargo conditions. A PDF of the paper mentioned on this release can be found in the Academic months or even years before the first symptoms of AD occur, which may allow for early diagnosis of at

Cai, Long

24

AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release  

E-print Network

AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release Jacob release. We have identified a direct physical interaction between M5 and the AP-3 adaptor complex, and mediated the binding of AP-3 to M5. Interaction with AGAP1 and activity of AP-3 were required for the endo

Sulzer, David

25

AccuNet/AP (Associated Press) Multimedia Archive  

ERIC Educational Resources Information Center

The AccuNet/AP Multimedia Archive is an electronic library containing the AP's current photos and a selection of pictures from their enormous print and negative library, as well as text and graphic material. It is composed of two photo databases as well as graphics, text, and audio databases. The features of this database are briefly described in

Young, Terrence E., Jr.

2004-01-01

26

Loss of AP-3 function affects spontaneous and evoked release at hippocampal mossy fiber synapses  

E-print Network

Loss of AP-3 function affects spontaneous and evoked release at hippocampal mossy fiber synapses for by the reformation of vesicles at plasma membrane and endosomes. Although the adaptor complex AP-3 was proposed on exocytosis remains unknown. Using mocha mice, which are deficient in functional AP-3, we identify an AP-3

Danglot, Lydia - Institut Jacques Monod, Université Paris 7

27

Frost & Sullivan Press Release Published: 14 Dec 2006  

E-print Network

Frost & Sullivan Press Release Published: 14 Dec 2006 https://www.frost.com/prod/servlet/press-release.pag?mode=open&docid=89716687 Frost & Sullivan Honours Mobileye N.V. with the 2006 Entrepreneurial Company of the Year Award in the Automotive Industry LONDON - December 14, 2006 ­ Frost & Sullivan confers the 2006 Entrepreneurial Company

Shashua, Amnon

28

PRESS RELEASE FROM KIDNEY INTERNATIONAL (www.nature.com/ki/)  

E-print Network

PRESS RELEASE FROM KIDNEY INTERNATIONAL (www.nature.com/ki/) This press release is copyrighted to Kidney International. Its use is granted only for journalists and news media receiving it directly from KIDNEY INTERNATIONAL AND THE KIDNEY INTERNATIONAL WEBSITE AS THE SOURCE OF THE FOLLOWING ITEM

Cai, Long

29

PressRelease|TheFitzwilliamMuseum Trumpington Street  

E-print Network

from the 16th to the 18th centuries in Gallery 7. - ENDS - #12;PressPressRelease|TheFitzwilliamMuseum Trumpington Street Cambridge CB2 1RB England 01223 332900 www supported by the Virgin Mary and Mary Magdalene, c. 1616 Oil on slate 37.2 x 28.6 cm A rare 17th century

Zeki, Semir

30

Hypoxia Press Release and Map - August 1, 2005  

NSDL National Science Digital Library

This EPA press release documents the findings of a 2005 mapping project in the Gulf of Mexico low-oxygen waters. The article notes the extent of the "dead zone" and notes the possible effects of Hurricane Dennis on the hypoxic zone. It also reports a smaller than expected nitrate content in the dead zone, which was attributed to the below average precipitation in the Mississippi River Basin. The press release also features a color map of the dead zone's extent.

Office, Epa- G.

31

Press Release EU, November 27th  

E-print Network

in the Animal and the Machine, MIT Press, 1948 A Rosenblueth, N Wiener, J Bigelow, "Behavior, purpose for physiological homeostasis", Physiological Reviews, 9:399-431, 1929. Walter B Cannon, The Wisdom of the Body, W W Norton & Co, 1932. Walter B Cannon, "The body physiologic and the body politic", Science, 93:1, 1941

32

PressRelease|TheFitzwilliamMuseum 4 August 2008  

E-print Network

, where Picasso's painting Guernica was first exhibited. These prints viciously lampoon General Franco Picasso added extra scenes in direct response to the Guernica bombing, this exhibition also complementsPressRelease|TheFitzwilliamMuseum 4 August 2008 Picasso and Whistler at The Fitzwilliam Museum

Zeki, Semir

33

PRESS RELEASE Ecole Centrale Paris, Altran, Mazars and Socit Gnrale  

E-print Network

members). Open Innovation is a business model that has adapted its innovation strategy to make the mostPRESS RELEASE Ecole Centrale Paris, Altran, Mazars and Société Générale create the Open Innovation the creation of the Open Innovation Institute (IOI). The Open Innovation Institute will be responsible

Paragios, Nikos

34

Vesicles derived via AP-3-dependent recycling contribute to asynchronous release and influence information transfer.  

PubMed

Action potentials trigger synchronous and asynchronous neurotransmitter release. Temporal properties of both types of release could be altered in an activity-dependent manner. While the effects of activity-dependent changes in synchronous release on postsynaptic signal integration have been studied, the contribution of asynchronous release to information transfer during natural stimulus patterns is unknown. Here we find that during trains of stimulations, asynchronous release contributes to the precision of action potential firing. Our data show that this form of release is selectively diminished in AP-3b2 KO animals, which lack functional neuronal AP-3, an adaptor protein regulating vesicle formation from endosomes generated during bulk endocytosis. We find that in the absence of neuronal AP-3, asynchronous release is attenuated and the activity-dependent increase in the precision of action potential timing is compromised. Lack of asynchronous release decreases the capacity of synaptic information transfer and renders synaptic communication less reliable in response to natural stimulus patterns. PMID:25410111

Evstratova, Alesya; Chamberland, Simon; Faundez, Victor; Tth, Katalin

2014-01-01

35

Money Income in the United States: 1998 (Press release)  

NSDL National Science Digital Library

This press release from the US Census Bureau announces that the number of Americans living under the poverty level dropped to 12.7 percent in 1998. This marks the fourth year in a row in which the median household income has risen. The reports, Money Income in the United States: 1998 and Poverty in the United States: 1998 break the data down demographically and highlight some of the more inclusive findings.

36

Widespread dysregulation of peptide hormone release in mice lacking adaptor protein AP-3.  

PubMed

The regulated secretion of peptide hormones, neural peptides and many growth factors depends on their sorting into large dense core vesicles (LDCVs) capable of regulated exocytosis. LDCVs form at the trans-Golgi network, but the mechanisms that sort proteins to this regulated secretory pathway and the cytosolic machinery that produces LDCVs remain poorly understood. Recently, we used an RNAi screen to identify a role for heterotetrameric adaptor protein AP-3 in regulated secretion and in particular, LDCV formation. Indeed, mocha mice lacking AP-3 have a severe neurological and behavioral phenotype, but this has been attributed to a role for AP-3 in the endolysosomal rather than biosynthetic pathway. We therefore used mocha mice to determine whether loss of AP-3 also dysregulates peptide release in vivo. We find that adrenal chromaffin cells from mocha animals show increased constitutive exocytosis of both soluble cargo and LDCV membrane proteins, reducing the response to stimulation. We also observe increased basal release of both insulin and glucagon from pancreatic islet cells of mocha mice, suggesting a global disturbance in the release of peptide hormones. AP-3 exists as both ubiquitous and neuronal isoforms, but the analysis of mice lacking each of these isoforms individually and together shows that loss of both is required to reproduce the effect of the mocha mutation on the regulated pathway. In addition, we show that loss of the related adaptor protein AP-1 has a similar effect on regulated secretion but exacerbates the effect of AP-3 RNAi, suggesting distinct roles for the two adaptors in the regulated secretory pathway. PMID:24086151

Sirkis, Daniel W; Edwards, Robert H; Asensio, Cdric S

2013-01-01

37

Release of 1-methylcyclopropene from heat-pressed polymer films.  

PubMed

Gaseous 1-methylcyclopropene (1-MCP) is an inhibitor of ethylene perception that is being used extensively for apples and ornamental products, and under intensive investigation for its potential benefits for other fruits and vegetables. 1-MCP is currently used in closed environments that maintain stable concentrations for several hours in order to be effective. However, food packaging materials that release 1-MCP at a predictable rate into the package headspace might be useful for application in inhibiting the deleterious effects of ethylene in the postharvest packaging and storage of some horticultural products. A 1-MCP/alpha-cyclodextrin (1-MCP-cd) complex was incorporated into several common packaging films by heat-pressing (dry-blend, lamination) and solution-casting methods. The release of 1-MCP from the films was quantified by gas chromatography with respect to time, loading of 1-MCP, temperature, relative humidity (RH), type of film, and film-forming method. Release of 1-MCP was rapid and high in films held at RH >/= 75%. The rate of release was slow during the 1st 12 h and then increased during the next 24 to 36 h. Higher temperatures resulted in higher and faster release. A loading of 8 mg of 1-MCP-cd per 140 mg of polymer was found to be optimal. Pressing 1-MCP-cd containing films above 100 degrees C reduced the amount of 1-MCP remaining in the film. Incorporation into LDPE resulted in a higher and faster release than from PS, PVC, and PP polymers. 1-MCP release from a film matrix appears to be within the acceptable range for produce packaging applications. PMID:17995734

Hotchkiss, J H; Watkins, C B; Sanchez, D G

2007-06-01

38

SIV Nef proteins recruit the AP-2 complex to antagonize Tetherin and facilitate virion release.  

PubMed

Lentiviral Nef proteins have multiple functions and are important for viral pathogenesis. Recently, Nef proteins from many simian immunodefiency viruses were shown to antagonize a cellular antiviral protein, named Tetherin, that blocks release of viral particles from the cell surface. However, the mechanism by which Nef antagonizes Tetherin is unknown. Here, using related Nef proteins that differ in their ability to antagonize Tetherin, we identify three amino-acids in the C-terminal domain of Nef that are critical specifically for its ability to antagonize Tetherin. Additionally, divergent Nef proteins bind to the AP-2 clathrin adaptor complex, and we show that residues important for this interaction are required for Tetherin antagonism, downregulation of Tetherin from the cell surface and removal of Tetherin from sites of particle assembly. Accordingly, depletion of AP-2 using RNA interference impairs the ability of Nef to antagonize Tetherin, demonstrating that AP-2 recruitment is required for Nef proteins to counteract this antiviral protein. PMID:21625568

Zhang, Fengwen; Landford, Wilmina N; Ng, Melinda; McNatt, Matthew W; Bieniasz, Paul D; Hatziioannou, Theodora

2011-05-01

39

JPL Press Release: NASA Astronomers Find Solar System Around Star  

NSDL National Science Digital Library

National Aeronautics and Space Administration astronomers, using the Keck II telescope in Hawaii, along with a team of scientists from the Harvard-Smithsonian Center for Astrophysics and the University of Florida, Gainesville, using the Cerro Tololo Observatory in Chile, "have discovered what appears to be the clearest evidence yet of a budding solar system around a nearby star." HR 4796, about 220 light years from Earth, "shows a swirling disk of dust around the star" that portends the building of a star system. The Jet Propulsion Laboratory press release explains the meaning of the findings.

1998-01-01

40

15864 Federal Register / Vol. 72, No. 63 / Tuesday, April 3, 2007 / Notices http://trade.gov/press/press_releases/  

E-print Network

://trade.gov/press/press_releases/ 2007/brazilceo_01.asp SUPPLEMENTARY INFORMATION: On March 23, 2007, the International Trade for the Laboratory Accreditation Program for Radiation Detection Instruments Under the National Voluntary Laboratory: Under the National Voluntary Laboratory Accreditation Program (NVLAP) the National Institute

41

PRESS RELEASE FROM MOLECULAR PSYCHIATRY (http://www.nature.com/mp)  

E-print Network

PRESS RELEASE FROM MOLECULAR PSYCHIATRY (http://www.nature.com/mp) This press release is copyrighted to the journal Molecular Psychiatry. PLEASE CITE MOLECULAR PSYCHIATRY AND THE MOLECULAR PSYCHIATRY with the amount of time people spend sleeping are identified this week in Molecular Psychiatry. Sleeping outside

Cai, Long

42

PRESS RELEASE FROM TRANSLATIONAL PSYCHIATRY (http://www.nature.com/tp)  

E-print Network

PRESS RELEASE FROM TRANSLATIONAL PSYCHIATRY (http://www.nature.com/tp) This press release is copyrighted to the journal Translational Psychiatry. Its use is granted only for journalists and news media to penalties and imprisonment. PICTURES: While we are happy for images from Translational Psychiatry

Cai, Long

43

PRESS RELEASE FROM MOLECULAR PSYCHIATRY (http://www.nature.com/mp)  

E-print Network

PRESS RELEASE FROM MOLECULAR PSYCHIATRY (http://www.nature.com/mp) This press release is copyrighted to the journal Molecular Psychiatry. Its use is granted only for journalists and news media we are happy for images from Molecular Psychiatry to be reproduced for the purposes

Cai, Long

44

UNIVERSITY OF EAST ANGLIA PRESS RELEASE OFT Imposes 225m Fine for Tobacco Price Fixing  

E-print Network

UNIVERSITY OF EAST ANGLIA PRESS RELEASE OFT Imposes £225m Fine for Tobacco Price Fixing This is the highest fine ever imposed by the OFT in a single case. Tobacco manufactures Imperial Tobacco and Gallaher for these tobacco products. http://www.oft.gov.uk/news/press/today?prid=695315 Dr Andreas Stephan of the Norwich Law

Feigon, Brooke

45

APS Receives Continued Funding from NIDDK  

NSDL National Science Digital Library

Press Release - BETHESDA, MD (September 22, 2010)? The American Physiological Society (APS; www.the-APS.org) has received continued funding from the National Institute of Diabetes and Digestive and Kidney Disease (NIDDK) for an additional two years of support effective July 1, 2010. The goal of the project is to encourage highly qualified students from groups underrepresented in the biomedical/behavioral sciences (especially underrepresented minority students) to pursue professional careers in physiological/biomedical sciences.

APS Communications Office (American Physiological Society Communications Office)

2010-09-22

46

PRESS RELEASE FROM TRANSLATIONAL PSYCHIATRY (http://www.nature.com/tp)  

E-print Network

PRESS RELEASE FROM TRANSLATIONAL PSYCHIATRY (http://www.nature.com/tp) For papers that will be published online on 9 July 2013 Thispress release iscopyrighted to the Translational Psychiatry. Itsuse the specific example. PLEASE CITE TRANSLATIONAL PSYCHIATRY AS THE SOURCE OF THE FOLLOWING ITEM. IF PUBLISHING

Cai, Long

47

PressRelease|TheFitzwilliamMuseum 09 January 2009  

E-print Network

as the `Insect Book', `Shell Book' and `Bird Book'. The extraordinary level of realistic detail contained within-press@lists.cam.ac.uk Birds, insect, fishes, shells and flowers appear elsewhere in the exhibition in a miscellany of guises - often not always immediately apparent in the image. In several instances, they are even present by means

Zeki, Semir

48

PressRelease|TheFitzwilliamMuseum Trumpington Street  

E-print Network

, in a special exhibition of ceramics from the 13th to 16th centuries. The 47 works from the Leventis Municipal into a Medieval French feudal kingdom that lasted for three centuries (1192-1489). It was in this period that most-press@lists.cam.ac.uk The designs on the pots reflect the life-style of the ruling Frankish class. The women wear fashionable

Zeki, Semir

49

PRESS RELEASE FROM TRANSLATIONAL PSYCHIATRY AND MOLECULAR For papers that will be published on online 04 October 2011  

E-print Network

PRESS RELEASE FROM TRANSLATIONAL PSYCHIATRY AND MOLECULAR PSYCHIATRY For papers that will be published on online 04 October 2011 This press release is copyrighted to Translational Psychiatry and Molecular Psychiatry. Its use is granted only for journalists and news media receiving it directly from

Cai, Long

50

PRESS RELEASE Charles University in Prague opens its doors wide to the world -computer science  

E-print Network

PRESS RELEASE Charles University in Prague opens its doors wide to the world - computer science course in computer science in English. In 1952, when the Faculty of Mathematics and Physics, Charles's and master's study programs in computer science with English as the language of instruction. Attention

Cerveny, Vlastislav

51

STANFORD AMATEUR RADIO STATION W6YX PRESS RELEASE June 19, 2008  

E-print Network

STANFORD AMATEUR RADIO STATION W6YX PRESS RELEASE ­ June 19, 2008 (Stanford, California) -- The Stanford Amateur Radio Club (call sign W6YX) will participate in Field Day, the annual emergency Relay League (ARRL, www.arrl.org), the national association for Amateur Radio (a.k.a. "ham radio

Straight, Aaron

52

Press Release Monday October 5th, 2009 UHM Scientists Spark Aerospace in Hawaii  

E-print Network

Press Release Monday October 5th, 2009 UHM Scientists Spark Aerospace in Hawaii Week Researchers from the School of Ocean and Earth Sciences and Technology at the University of Hawaii at Manoa will participate in lively panel discussions this week as part of Aerospace Week in Hawaii. All presentations

53

Newport Beach Police Department Press Release870 Santa Barbara Dr., Newport Beach, CA 92660  

E-print Network

Newport Beach Police Department Press Release870 Santa Barbara Dr., Newport Beach, CA 92660, at approximately 8 a.m., Newport Beach Police Detectives served a search warrant in the 1000 block of Valencia for 496 PC ­ Possession of Stolen Property. They were booked at the Newport Beach Police Jail and were

Rose, Michael R.

54

Press Release from Dublin City University Dublin City University Licenses CAD Technology to UK Medical Imaging  

E-print Network

Press Release from Dublin City University 12th March 2010 Dublin City University Licenses CAD Technology to UK Medical Imaging Company Biotronics3D Ltd. Dublin City University (DCU) has agreed to license Foundation Ireland (SFI Principal Investigator). #12;About Dublin City University Dublin City University (www

Whelan, Paul F.

55

Corporate Responsibility in Communication: Empirical Analysis of Press Releases in a Conflict  

ERIC Educational Resources Information Center

The paper examines how the tensions of corporate responsibility are articulated and reconciled in a controversial situation of a foreign investment. We conducted a conventionalist analysis on the company press releases in a case where a Finnish forest industry company invested in a pulp mill in South America. The findings show that the use of

Lehtimaki, Hanna; Kujala, Johanna; Heikkinen, Anna

2011-01-01

56

PRESS RELEASES OF SENATOR PETE DOMENICI Domenici Supports 12 Percent Increase for Nuclear Energy, Disputes Fusion  

E-print Network

PRESS RELEASES OF SENATOR PETE DOMENICI Domenici Supports 12 Percent Increase for Nuclear Energy his support for a 12 percent increase in federal funding for nuclear energy research, but challenged of modern nuclear power plants. Domenici is chairman of the Energy and Water Development Appropriations

57

AFS Press Release June 26, 2007 The Anthropology Program is currently hosting an archaeology field school  

E-print Network

AFS Press Release June 26, 2007 The Anthropology Program is currently hosting an archaeology field school are to provide training in archaeological methods, and to further explore the depth and richness, making it the largest university archaeology field school in British Columbia and one of the largest

Bolch, Tobias

58

Solid-state diffusion welding of wrought AISI 304 stainless steel to Nimonic AP-1 superalloy powder by hot isostatic pressing  

SciTech Connect

The diffusion welding characteristics of wrought AISI 304 stainless steel to a superalloy powder Nimonic AP-1 were examined in this study. After encapsulation, evacuation and degassing, the welds were hot isostatically pressed (HIPed) in two different cycles, i.e., 1,200 C (2,192 F)/3h/147 MPa and 1,270 C (2,318 F)/3h/121 MPa. A variation in surface condition of stainless steel was also studied for its influence on properties of the joints. These diffusion-welded joints were characterized for diffusion of alloying elements, microstructural features and tensile properties.

Somani, M.C.; Birla, N.C. [Defence Metallurgical Research Lab., Hyderabad (India); Tekin, A. [Istanbul Technical Univ., Istanbul (Turkey). Dept. of Chemical and Metallurgical Engineering

1998-02-01

59

Distorting Genetic Research about Cancer: From Bench Science to Press Release to Published News1  

PubMed Central

This study considered genetic research relating to cancer outcomes and behaviors, specifically investigating the extent to which claims made in press releases (N=23) and mainstream print media (N=71) were fairly derived from their original presentation in scholarly journals (N=20). Central claims expressing gene-outcome relationships were evaluated by a large pool (N=40) of genetics graduate students. Raters judged press release claims as significantly more representative of material within the original science journal article compared with news article claims. Claims originating in news articles which demonstrated contact with individuals not directly involved in the research were judged by experts to be more representative of the original science as compared with those that demonstrated contact with individuals directly involved in the research. PMID:25580022

Brechman, Jean M.; Lee, Chul-joo; Cappella, Joseph

2014-01-01

60

Nanotechnology Now -Press Release: "Researchers directly deposit gold nanoparticles in suspension" Web www.nanotech-now.com  

E-print Network

Nanotechnology Now - Press Release: "Researchers directly deposit gold nanoparticles in suspension" Web www.nanotech-now.com Our NanoNews Digest Sponsors Home > Press > Researchers directly deposit gold in biosensing applications. Researchers directly deposit gold nanoparticles in suspension Chicago, IL | Posted

Espinosa, Horacio D.

61

Studies on applicability of press-coated tablets using hydroxypropylcellulose (HPC) in the outer shell for timed-release preparations  

Microsoft Academic Search

Press-coated tablets, containing diltiazem hydrochloride (DIL) in the core tablet and coated with hydroxypropylcellulose (HPC) as the outer shell, were examined for applicability as timed-release tablets with a predetermined lag time and subsequent rapid drug release phase. Various types of press-coated tablets were prepared using a rotary tabletting machine and their DIL dissolution behavior was evaluated by the JP paddle

Eiji Fukui; Katsuji Uemura; Masao Kobayashi

2000-01-01

62

Formaldehyde-releasers: relationship to formaldehyde contact allergy. Part 2. Formaldehyde-releasers in clothes: durable press chemical finishes.  

PubMed

This is the second part of a review article on formaldehyde-releasers used as durable press chemical finishes (DPCF) in textiles. The early finishes contained large amounts of free formaldehyde, which led to many cases of allergic contact dermatitis to clothes in the 1950s and 1960s. Currently, most finishes are based on modified dimethylol dihydroxyethyleneurea, which releases less formaldehyde. Nevertheless, recent studies in the United States and Israel have identified patients reacting to DPCF, considered to have allergic contact reactions to clothes, either from formaldehyde released by the DPCF therein or from the DPCF per se (in patients negative to formaldehyde). However, all studies had some weaknesses in design or interpretation and in not a single case has the clinical relevance been proven. The amount of free formaldehyde in most garments will likely be below the threshold for the elicitation of dermatitis for all but the most sensitive patients. The amount of free cyclized urea DPCF in clothes is unlikely to be high enough to cause sensitization. Patch test reactions to formaldehyde-releasing DPCF will in most cases represent a reaction to formaldehyde released from the test material. PMID:20236157

de Groot, Anton C; Le Coz, Christophe J; Lensen, Gerda J; Flyvholm, Mari-Ann; Maibach, Howard I; Coenraads, Pieter-Jan

2010-07-01

63

"Discoveries in Planetary Sciences": Turning Press Release Science into Teachable Moments in Higher Ed  

NASA Astrophysics Data System (ADS)

AGU disciplines are all fields that evolve rapidly, and it can take several years for new advances to work their way into college textbooks. Yet it is important for students to have exposure to these new advances for a number of reasons. In some cases, new work renders older textbook knowledge incorrect or incomplete. In some cases, new discoveries make it possible to emphasize older textbook knowledge in a new way. In all cases, new advances provide exciting and accessible examples of the scientific process in action. But press releases rarely provide these "teachable moments" in either content or format. To bridge the gap between textbooks and new advances in planetary sciences, we have developed content on new discoveries for use by undergraduate instructors. Called 'Discoveries in Planetary Sciences', each new discovery is summarized in a 3-slide PowerPoint presentation. The first slide describes the discovery, the second slide discusses the underlying planetary science concepts, and the third presents the big picture implications of the discovery. A fourth slide includes links to associated press releases, images, and primary sources. This effort is generously sponsored by the Division for Planetary Sciences of the American Astronomical Society, and the slide sets are available at http://dps.aas.org/education/dpsdisc/. More than twenty slide sets have been released so far covering topics spanning all sub-disciplines of planetary science, with a fall release planned for Spanish translations In this presentation we will discuss our motivation for this project, our implementation approach (from choosing topics to creating the slide sets, to getting them reviewed and released), and give examples of slide sets. We will present information in the form of web statistics on how many educators are using the slide sets, and which topics are most popular. We will also present feedback from educators who have used them in the classroom. The value and popularity of these slide sets in planetary science makes an excellent case for expansion to all AGU disciplines.

Schneider, N. M.; Brain, D.; Sada, P. V.

2011-12-01

64

Coverage of Team Science by Public Information Officers: Content Analysis of Press Releases about the National Science Foundation Science and Technology Centers  

ERIC Educational Resources Information Center

This study examines the content of press releases from the National Science Foundation (NSF) Science and Technology Centers (STCs) to determine how public information officers (PIOs) presented the outcomes of centers to journalists and the public. A total of 68 press releases were analyzed for type of news covered, visibility of centers and their

Graube, Marita; Clark, Fiona; Illman, Deborah L.

2010-01-01

65

Lost in Translation? A Comparison of Cancer-Genetics Reporting in the Press Release and its Subsequent Coverage in Lay Press1  

PubMed Central

Understanding how genetic science is communicated to the lay public is of great import, given that media coverage of genetics is increasing exponentially and that the ways in which discoveries are presented in the news can have significant effects on a variety of health outcomes. To address this issue, this study examines the presentation of genetic research relating to cancer outcomes and behaviors (i.e., prostate cancer, breast cancer, colon cancer, smoking and obesity) in both the press release (N = 23) and its subsequent news coverage (N = 71) by using both quantitative content analysis and qualitative textual analysis. In contrast to earlier studies reporting that news stories often misrepresent genetics by presenting biologically deterministic and simplified portrayals (e.g., Mountcastle-Shah et al., 2003; Ten Eych & Williment, 2003), our data shows no clear trends in the direction of distortion toward deterministic claims in news articles. Also, other errors commonly attributed to science journalism, such as lack of qualifying details and use of oversimplified language (e.g., fat gene) are observed in press releases. These findings suggest that the intermediary press release rather than news coverage may serve as a source of distortion in the dissemination of science to the lay public. The implications of this study for future research in this area are discussed. PMID:25568611

Brechman, Jean M.; Lee, Chul-joo; Cappella, Joseph N.

2014-01-01

66

PRESS RELEASE Contact: Rita Davis, Fort Collins Police Services, 970-221-6628, rdavis@fcgov.com  

E-print Network

PRESS RELEASE Contact: Rita Davis, Fort Collins Police Services, 970-221-6628, rdavis.m. Fort Collins police were notified of a sex assault in the area of 100 W. Lake St. in central Fort Collins adjacent to the CSU campus. The victim, a 22 year-old CSU student, was approached by and unknown

Stephens, Graeme L.

67

Voluntary Pressing and Releasing Actions Induce Different Senses of Time: Evidence from Event-Related Brain Responses  

PubMed Central

The timing intervals initiated by voluntary pressing actions are subjectively compressed compared with those initiated by voluntary releasing actions. Event-related potentials (ERPs) were employed in the present study to uncover the temporal mechanisms underlying this temporal illusion. The results revealed that the mean amplitude of the P1 component over the frontal-central recording sites, but not the P2 component, was larger in the voluntary pressing condition than in the voluntary releasing condition at the time perception stage. In the fronto-central region, increases in oscillatory activities of delta-theta frequency range (1-7?Hz) were found in the voluntary pressing condition, which corresponded with the emergence of the P1 peak. In addition, the P1 amplitude was negatively related to the corresponding reported time length at the single-trial level. These results are discussed in terms of the functional role of the response-locked P1 in the time perception stage. PMID:25116363

Zhao, Ke; Gu, Ruolei; Wang, Liang; Xiao, Ping; Chen, Yu-Hsin; Liang, Jing; Hu, Li; Fu, Xiaolan

2014-01-01

68

Nov. 12: It's How You Play the Game: Carnegie Mellon Professor Asks What a Video Game Tells Us About Making Peace -Carnegie Mellon University Press Releases  

E-print Network

Jonathan Potts 412-268-6094 jpotts@andrew.cmu.edu It's How You Play the Game: Carnegie Mellon ProfessorNov. 12: It's How You Play the Game: Carnegie Mellon Professor Asks What a Video Game Tells Us About Making Peace - Carnegie Mellon University News Press Releases 2007 Releases November Nov. 12: It

69

FOR IMMEDIATE RELEASE Press contact: Christina Jensen PR, 646.536.7864  

E-print Network

-Stars and the luminous Norwegian vocal ensemble Trio Mediaeval. Michael Gordon's Timber, recently released on Cantaloupe, otherworldly, and sweeping meditation on sound and rhythm. Timber was released on Cantaloupe Music in August

Polz, Martin

70

Thermally induced atomic diffusion at the interface between release agent coating and mould substrate in a glass moulding press  

NASA Astrophysics Data System (ADS)

In a glass moulding press (GMP) for refractive/diffractive hybrid lenses, to improve the service life of nickel-phosphorus (Ni-P) plated moulds, it is necessary to control the diffusion of constituent elements from the mould into the release agent coating. In this study, diffusion phenomena of constituents of Ni-P plating are investigated for two types of release agent coatings, iridium-platinum (Ir-Pt) and iridium-rhenium (Ir-Re), by cross-sectional observation, compositional analysis and stress measurements. The results show that Ni atoms in the plating layer flow from regions of compressive stress to regions of tensile stress. In the case of the Ir-Pt coated mould, the diffusion of Ni is promoted from the grain boundaries between the Ni and Ni3P phases in the plating towards the surface of the Ir-Pt coating. However, in the Ir-Re coated mould, the diffusion of Ni is suppressed because the diffusion coefficient of Ni in the Ir-Re alloy is smaller than that in the Ir-Pt alloy, although the stress state is similar in both cases. By controlling the diffusion of Ni atoms, the use of Ir-Re alloy as a release agent coating for Ni-P plated moulds is expected to lead to a high degree of durability.

Masuda, Jun; Yan, Jiwang; Zhou, Tianfeng; Kuriyagawa, Tsunemoto; Fukase, Yasushi

2011-06-01

71

Press Release: The World Wide Web Consortium Issues SMIL 1.0 as a W3C Recommendation  

NSDL National Science Digital Library

The World Wide Web Consortium (W3C) has issued its first recommendation for Synchronized Multi-media Integration Language. The specification intends to help "bring television-like content to the web, avoiding the limitations for traditional television and lowering the bandwidth requirements for transmitting this type of content over the Internet. With SMIL [pronounced smile], producing audio-visual content is easy; it does not require learning a programming language and can be done using a simple text editor." Easy authorship, accessibility, and improvement of bandwidth efficiency are among a few of the promises that SMIL may bring closer to reality. The site contains a press release and more information about SMIL.

1998-01-01

72

Megaconference V Reaches Five Continents http://www.osc.edu/press/releases/2003/megaconference.shtml 1 of 3 9/19/2008 12:34 PM  

E-print Network

Megaconference V Reaches Five Continents http://www.osc.edu/press/releases/2003/megaconference.shtml 1 of 3 9/19/2008 12:34 PM Megaconference V Reaches Five Continents More than 1000 people from over 200 institutions in 27 countries on five continents dialed into the 5th Annual Megaconference

Calyam, Prasad

73

NATIONAL PRESS RELEASE I PARIS I 30 AUGUST 2013 Brown algae contain phlorotannins, aromatic (phenolic) compounds that are unique in the plant  

E-print Network

NATIONAL PRESS RELEASE I PARIS I 30 AUGUST 2013 Brown algae contain phlorotannins, aromatic elucidated the key step in the production of these compounds in Ectocarpus siliculosus, a small brown alga phlorotannins from brown algae for use in industry was a complex process, and the biosynthesis pathways

Canet, Léonie

74

Press release embargoed until 6.00am Thursday 22 August 2013 Find a 3D fossil the hunt is on!  

E-print Network

Press release ­ embargoed until 6.00am Thursday 22 August 2013 Find a 3D fossil ­ the hunt is on Geological Survey that will see fossil types freely available to all. They are also running a competition County Museum. The `type' specimen of a fossil is the one to which all other similar specimens

Cambridge, University of

75

NATIONAL PRESS RELEASE I PARIS I 18 NOVEMBER 2013 Cancer chronotherapy consists in administering treatment at an optimal time. Because the  

E-print Network

towards personalized chronotherapy treatments. In an article published in the journal Cancer Research studied the toxicity of irinotecan, an anti-cancer drug widely used in the treatment of cancer NATIONAL PRESS RELEASE I PARIS I 18 NOVEMBER 2013 Cancer chronotherapy consists

Canet, Léonie

76

NATIONAL PRESS RELEASE I PARIS I 12 JULY 2013 In nature, many forms of plant-animal mutualism exist in which each partner benefits from the  

E-print Network

into leaf production, which means more leaf pockets. But the plant has a defense mechanism. If too many budsNATIONAL PRESS RELEASE I PARIS I 12 JULY 2013 In nature, many forms of plant-animal mutualism exist a plant and an ant. In French Guiana, the Hirtella physophora plant is capable of retaliating against

Canet, Léonie

77

Plutonium release from pressed plutonium oxide fuel pellets in aquatic environments  

SciTech Connect

Plutonium oxide pellets (80% /sup 238/Pu, 40 g each) were exposed to fresh water and sea water at two temperatures for 3 y in enclosed glass chambers. The concentrations of plutonium observed in the waters increased linearly with time throughout the experiment. However, the observed release rates were inversely dependent on temperature and salinity, ranging from 160 ..mu..Ci/day for cold fresh water to 1.4 ..mu..Ci/day for warm sea water. The total releases, including the chamber residues, showed similar dependencies. A major portion (typically greater than 50%) of the released plutonium passed through a 0.1-..mu..m filter, with even larger fractions (greater than 80%) for the fresh water systems.

Patterson, J.H.; Steinkruger, F.J.; Matlack, G.M.; Heaton, R.C.; Coffelt, K.P.; Herrera, B.

1983-12-01

78

Properties of tritium/helium release from hot isostatic pressed beryllium of various trademarks  

NASA Astrophysics Data System (ADS)

Samples of three industrial beryllium trademarks, such as S-200F, S-65H and I-220H are irradiated at about 40 C to the fluence of 1.5 1024 m-2 (E > 1.15 MeV) in reactor WWR-K. On completion of irradiation tests, post irradiation examinations (PIEs) against hardness are carried out, X-ray diffraction (XRD) analysis and scanning electron microscope (SEM) observation. Also He/T2 release properties are measured by the thermal desorption (TDS) method. Relevant obtained values of amounts of the released tritium and helium for all samples of irradiated beryllium are in good agreement, within inaccuracy, comprising 25 3 wppm for helium-4 and 1.3 0.3 wppm for tritium.

Chekushina, Lyudmila; Dyussambaev, Daulet; Shaimerdenov, Asset; Tsuchiya, Kunihiko; Takeuchi, Tomoaki; Kawamura, Hiroshi; Kulsartov, Timur

2014-09-01

79

Press Release FOR IMMEDIATE RELEASE  

E-print Network

argument on Hippocampus, the key part of the brain responsible for forming new memories ­ and was judged' prize for fielding the largest number of contestants in the open auditions. This prize is intended

Tam, Vincent W. L.

80

PRESS RELEASE For immediate release  

E-print Network

Foundation in the well-being of Canadian women has been outstanding in the past years. The dedication this mission at all levels of women's lives," says Dr. Tremblay of the Goodman Cancer Research Centre and clinical research, but the Roses of Hope leadership had the vision that current therapies are not enough

Kambhampati, Patanjali

81

Reciprocating pellet press  

DOEpatents

A machine for pressing loose powder into pellets using a series of reciprocating motions has an interchangeable punch and die as its only accurately machines parts. The machine reciprocates horizontally between powder receiving and pressing positions. It reciprocates vertically to press, strip and release a pellet.

Jones, Charles W. (Seminole, FL)

1981-04-07

82

Flame structure in aluminized wide-distribution AP composite propellants  

Microsoft Academic Search

Flame structure in wide-distribution ammonium-perchlorate (AP), hydroxyl-terminated-polybutadiene (HTPB) binder, aluminum (Al) composite propellants is studied using 2-D laminates with oxygenated binder. Very fine (2-?m) AP (FAP) is used to produce fuel-rich, matrix propellant (oxygenated binder) with a FAP\\/binder ratio of 75\\/25. Coarse AP (CAP) is simulated by pressed AP lamina. A flame-structure regime map for the CAP\\/oxy-fuel matrix interaction flame

M. Q. Brewster; J. C. Mullen

2010-01-01

83

CRCHD - News Releases  

Cancer.gov

CRCHD - News Releases Home News and Events News Releases News Releases E-bulletin News Stories Spotlights Meetings & Events Press Kit News Releases & Articles 2012 New! CRCHD PNRP Grantees Publish Research

84

Public Relations Press Release  

E-print Network

to the late Eocene. These freshwater sediments contained a wealth of fossilized animals and plants. During of the carp family. They grow up to a length of 1.5 meters and can weigh in at 50 kilograms. Besides, as a means to control aquatic plants. Only later did researchers discover that the bighead carp failed to Dr

Ould Ahmedou, Mohameden

85

Public Relations Press Release  

E-print Network

. It is a chronic inflammatory disease of the arteries arising from in- teractions of modified lipoproteins in mice, in which they have genetically labeled mature SMCs in the vessel wall of young mice before the onset of the disease and then monitored their fate in older atherosclerotic animals. "Surprisingly, we

Tübingen, Universität

86

SANC press release  

NASA Astrophysics Data System (ADS)

In a bunch of four talks, presented at this conference, we describe the SANC version 0.03, which is capable of automatically computing the decay rates and the distributions for the simplest SM decays Z( H,W)? ff in terms of the one-loop approximation. The main aim of this version is to demonstrate the efficacy of the proposed four-level computer system, which is intended for realizing the Support Analytic and Numeric calculations for experiments at Colliders.

Andonov, A.; Bardin, D.; Bondarenko, S.; Christova, P.; Kalinovskaya, L.; Nanava, G.; Passarino, G.

2003-04-01

87

Press Release - Dec 1995  

Cancer.gov

Mortality data have shown for several decades that breast cancer death rates are higher in the Northeast than in other regions of the country, particularly the South. But the new analysis demonstrates that the Northeast, Midwest, and West have a similar mortality risk after taking into account factors such as age at first live birth. Moreover, the differences between these regions and the South narrowed after accounting for such factors.

88

Public Relations Press Release  

E-print Network

has global food production. As a result, the use of pesticides and their effect on humans, animals in the research which have prevented recognition of the consequences of biochemical pesticide effects on a species animals and the endangerment of species such as amphibians. Can the biochemical effects of pesticides

Tübingen, Universität

89

kommunikation Press Release  

E-print Network

: The radiocarbon chronology of Gei?enklösterle. Journal of Human Evolution. Contact: Prof. Nicholas Conard Ph. D from the from Gei?enklösterle Cave in Swabian Jura of Southwestern Germany in the Journal of Human Gei?enklösterle Cave in Southwest Germany document the early arrival of modern humans and early appearance of art

Lubich, Christian

90

PRESS RELEASE FROM NEUROPSYCHOPHARMACOLOGY  

E-print Network

OF THE FOLLOWING ITEM. IF PUBLISHING ONLINE, PLEASE CARRY A HYPERLINK TO http://www.nature.com/npp Using marijuana of the psychoactive ingredient in marijuana, produces a longer duration of pain relief than smoked marijuana of intoxication and potential for abuse associated with the smoked route of administration of marijuana

Cai, Long

91

PRESS RELEASE FROM NEUROPSYCHOPHARMACOLOGY  

E-print Network

, PLEASE CARRY A HYPERLINK TO http://www.nature.com/npp Smoking throughout pregnancy may contribute to emotional problems in children *PODCAST* DOI: 10.1038/NPP.2013.273 Smoking throughout pregnancy may have long-term effects on brain development and contribute to emotional problems in young children

Cai, Long

92

Press Release Corporate Communications  

E-print Network

Advanced Grant, which makes her the first, female, German, computer scientist to be awarded one of those prestigious awards, elevates her to the ranks of the research elite in her chosen field. Only three other German computer scientists before her have received an ERC Advanced Grant. ERC Advanced Grants are

Haller-Dintelmann, Robert

93

Staff Council Press Release  

E-print Network

-Chair 713-743-6030 rszwarc@uh.edu Staff Council Sock & Blanket Drive to Help Houston's Homeless and Adults has been serving Houston's homeless since 1907. They provide food, clothing, shelter, and other services to the homeless through emergency shelters, transitional living centers, and out

Azevedo, Ricardo

94

Public Relations Press Release  

E-print Network

of disease in the context of historical pandemics such as the medieval outbreaks of the plague. Little the outbreak of plague in Ath- ens in the 4th century BC and the Antonine Plague in the 2nd century AD of the plague ­ and established that all today's forms are descended from it, being little changed from

Tübingen, Universität

95

PRESS RELEASE FROM NEUROPSYCHOPHARMACOLOGY  

E-print Network

TO http://www.nature.com/npp Antidepressants during pregnancy and fetal development DOI: 10.1038/NPP.2014 on prenatal exposure to antidepressants, reports a small study published in Neuropsychopharmacology studies are completed. Antidepressants such as selective serotonin reuptake inhibitors (SSRIs

Cai, Long

96

PRESSMEDDELANDE Press release  

E-print Network

was extremely controversial. In the course of defending his findings, he was asked to leave his research group of matter. Aperiodic mosaics, such as those found in the medieval Islamic mosaics of the Alhambra Palace

Adler, Joan

97

Public Relations Press Release  

E-print Network

with an attractively structured training program in eight areas of specialization as well as in scientific methods with a supervisor. The new PhD candidates say this program will give them better training in scientific method English-language PhD program combines medical and scientific research training Tübingen, 06

Tübingen, Universität

98

PRESS RELEASE FROM NEUROPSYCHOPHARMACOLOGY  

E-print Network

it addictive. Additional data shows that exposure to HIV-1 Tat protein caused reinstatement of cocaine.1038/NPP.2013.201 A protein associated with HIV infection may increase vulnerability for cocaine abuse the behavioral response to cocaine. The presence of HIV-1 Tat increased both the stimulant and rewarding effects

Cai, Long

99

Public Relations Press Release  

E-print Network

launched the first modern eyeglass lens on the market back in 1912, many major advances have been achieved lens and the retina are fully understood, experts predict a significant advance in the treatment Group. "This totally unique competence cluster of neurology, medicine and ophthalmic optics, the widely

Tübingen, Universität

100

Press Release Corporate Communications  

E-print Network

-Darmstadt scientists have found a way to promptly detect hacker attacks on virtual machines. Companies and government's or government-agency's network due to hacker attacks. An entire virtual machine and all of the data stored that recognizes such echo-profiles and triggers protective countermeasures that combat hacker attacks. However, he

Hoffmann, Rolf

101

CRCHD - News Releases  

Cancer.gov

CRCHD - News Releases Home News and Events News Releases Health Disparities News & Articles E-bulletin News Stories & Interviews CRCHD Spotlights Meetings & Events Press Kit News Releases & Articles 2012

102

1/9/09 2:14 PMResearchers Pinpoint Spontaneous Gene Mutations Responsible for 10 Percent of Non-Familial Cases of Schizophrenia Page 1 of 3http://cumc.columbia.edu/news/press_releases/gene-mutation-schizophrenia.html  

E-print Network

-Familial Cases of Schizophrenia Page 1 of 3http://cumc.columbia.edu/news/press_releases/gene-mutation-schizophrenia Gene Mutations Responsible for 10 Percent of Non-Familial Cases of Schizophrenia NEW YORK (May 30, 2008) ­ Scans of the genome of patients with schizophrenia have revealed rare spontaneous copy number mutations

103

Opening AP to All  

ERIC Educational Resources Information Center

This article reports on a school's effort to open Advanced Placement (AP) to all by challenging its students to take the leap into AP courses. Samuel W. Wolfson High School, on the south side of Jacksonville, Florida, is one of 27 schools in five cities across the country that chose to participate in a College Board initiative called EXCELerator.

Gewertz, Catherine

2008-01-01

104

EUROPA Press Room: The European Commission's On-line Press Room  

NSDL National Science Digital Library

Available in English, German, and French, the European Commission's (EC) online press room is an excellent resource for any users interested in the latest news and press releases from the EC and the European Union. At the site, visitors will find links to the latest headlines and releases (many available in multiple languages), a weekly archive, a searchable database of press releases since 1985, and links to video news, photos, and other resources. Registered users may also sign up to receive free electronic press releases on designated areas of interest.

2001-01-01

105

APS: Active Parameter Searching  

NASA Astrophysics Data System (ADS)

APS finds Frequentist confidence limits on high-dimensional parameter spaces by using Gaussian Process interpolation to identify regions of parameter space for which chisquared is less than or equal to some specified limit. The code is written in C++, is robust against multi-modal chisquared functions and converges comparably fast to Monte Carlo methods. Code is also provided to draw Bayesian credible limits using the outputs of APS, though this code does not converge as well. APS requires the linear algebra libraries LAPACK, BLAS, and ARPACK (ascl:1311.010) to run.

Daniel, Scott F.; Connolly, Andrew J.; Schneider, Jeff

2014-08-01

106

AP Central: AP Biology Course Home Page  

NSDL National Science Digital Library

For students and educators seeking to learn more about the world of biology, this website is the perfect resource. Created by the College Board, this site contains information designed to help individuals prepare for the AP Biology examination. The resources here include a guide to conducting investigative labs in the classroom, an overview of quantitative skills, and several other preparatory items. In the Classroom Resources area, visitors can look over curriculum modules and field trip suggestions among other tools. The "Related Articles" section features pieces such as "Mendel's Legacy," "Gastrulation: Shaping the Embryo," and "DNA and Computers-A Marriage Made in Heaven." The site is rounded out by a series of course overviews crafted specially for AP Biology instructors.

107

FOR IMMEDIATE RELEASE Press contacts  

E-print Network

journalistic ethics apply to the digital space, as well as analyzing and evaluating new business models as an editor on the business desk, and before that she was Business Editor at the Detroit News. She earned her evolution of the media business. The magazine, offering a mix of reporting, analysis, and commentary

Hone, James

108

CSR Press Release Submitted by  

E-print Network

Round Table, The Business Ethics, Corporate Social Responsibility Aug 02, 2010 ­ 11:07 AM EST BEIJING for International Business Ethics, Beijing. Resource organizations are: The Central Party School, University become a major driving force in the adoption of responsible and ethical business as the means to ensure

109

Press Release | October 6, 2010  

E-print Network

in Quebec to Ban Sale of Single-Use Bottled Water Sherbrooke, QC ­ Bishop's University students who began officially become the first university in Quebec to ban the sale of single-use bottled water on its campus initiated a "Think Global, Drink Local" campaign to raise awareness of the negative impacts of bottled water

110

CSR Press Release Submitted by  

E-print Network

most executives surveyed said that their sustainability programs focused on a triple bottom line model approaching sustainability through ad hoc programs or isolated initiatives do not achieve their desired carbon emissions - helping them to comply with climate change legislation and save money at the same time

111

PRESS RELEASE RARE FRUIT CONFERENCE  

E-print Network

its conception in 1984. It features visits to botanical gardens, research Botanical Garden ­ this magnificent historic garden was the home of Dr. David Fairchild and is now part of the National Botanical Garden. · TREC, University of Florida, Homestead ­ Part of the University of Florida

Jawitz, James W.

112

PRESS RELEASE 22 December 2009  

E-print Network

drink products, to PAS 2050, the carbon footprint standard which was launched in October 2008. Hey Song efforts to promote environmental aw areness. After accomplishing the inspection of our carbon footprint issued in Taiw an since BSI announced its carbon footprint inspection standard at the end of 2008. It

113

PRESS RELEASE FROM TRANSLATIONAL PSYCHIATRY  

E-print Network

impairment, repetitive behaviour and restricted interests. The inhibitory neurotransmitter GABA is known intracellular chloride and to reinforce the inhibitory actions of GABA. They report in 60 autistic and asperger

Cai, Long

114

Autoantibody profiling in APS.  

PubMed

The international consensus for the classification of antiphospholipid syndrome (APS) requires clinical and laboratory criteria to be considered at an equal level for diagnosing APS. Thus, detection of antiphospholipid antibodies (aPL) being a hallmark of APS has been the object of intensive investigation over the past 40 years. However, appropriate detection of aPL still remains a laboratory challenge due to their heterogeneity comprising autoantibodies reactive to different phospholipid-binding plasma proteins, such as beta-2 glycoprotein I (?2GPI) and prothrombin. The relevance of aPL interacting with phospholipids other than cardiolipin (CL, diphosphatidylglycerol), such as phosphatidylserine (PS), remains elusive with regard to the diagnosis of APS. Recently, the concept of aPL profiling has been introduced to assess the risk of thrombotic complications in patients with APS. New assay techniques, apart from enzyme-linked immunosorbent assays (ELISAs) recommended by the international consensus for the classification of APS, have been proposed for multiplexing of aPL testing. Line immunoassays (LIAs) employing a novel hydrophobic solid phase for the simultaneous detection of different aPL seem to be an intriguing alternative. We evaluated a novel multiplex LIA employing a hydrophobic membrane coated with different phospholipid (PL)-binding proteins or PLs. The performance characteristics of this new multiplexing assay technique demonstrated its usefulness for aPL profiling. PMID:25228721

Roggenbuck, D; Somma, V; Schierack, P; Borghi, M O; Meroni, P L

2014-10-01

115

APS Science 2009.  

SciTech Connect

It is my pleasure to introduce the 2009 annual report of the Advanced Photon Source. This was a very good year for us. We operated with high reliability and availability, despite growing problems with obsolete systems, and our users produced a record output of publications. The number of user experiments increased by 14% from 2008 to more than 3600. We congratulate the recipients of the 2009 Nobel Prize in Chemistry-Venkatraman Ramakrishnan (Cambridge Institute for Medical Research), Thomas Steitz (Yale University), and Ada Yonath (Weizmann Institute) - who did a substantial amount of this work at APS beamlines. Thanks to the efforts of our users and staff, and the ongoing counsel of the APS Scientific Advisory Committee, we made major progress in advancing our planning for the upgrade of the APS (APS-U), producing a proposal that was positively reviewed. We hope to get formal approval in 2010 to begin the upgrade. With advocacy from our users and the support of our sponsor, the Office of Basic Energy Sciences in the Department of Energy (DOE) Office of Science, our operating budgets have grown to the level needed to more adequately staff our beamlines. We were also extremely fortunate to have received $7.9 M in American Recovery and Reinvestment Act ('stimulus') funding to acquire new detectors and improve several of our beamlines. The success of the new Linac Coherent Light Source at Stanford, the world's first x-ray free-electron laser, made us particularly proud since the undulators were designed and built by the APS. Among other highlights, we note that more than one-quarter of the 46 Energy Frontier Research Centers, funded competitively across the U.S. in 2009 by the DOE, included the Advanced Photon Source in their proposed work, which shows that synchrotron radiation, and the APS in particular, are central to energy research. While APS research covers everything from fundamental to applied science (reflected by the highlights in this report), the challenge of sustainable energy provides an opportunity for expanded involvement with industrial research. We were privileged to recruit several outstanding new leaders at the APS. Linda Young, from Argonne's Chemical Sciences Division, became the new Director of the X-ray Science Division (XSD). Chris Jacobsen (from Stony Brook University) has been added to Linda's team as an XSD Associate Division Director, joining George Srajer. Alexander (Sasha) Zholents (formerly of Berkeley Lab) became Director of the Accelerator Systems Division. Sasha is the inventor of the short-pulse x-ray scheme that we plan to implement in the APS-U to obtain very high average brightness, broadband, 1-ps x-ray pulses. Walter Lowe (formerly of Howard University) has taken a new position as senior advisor for outreach and development of the user community. Walter's role is to increase the diversity of the user community (with diversity read broadly to include users, institutions, and technical disciplines that are underrepresented at APS). Walter is also leading an effort to increase access for industrial users. I am confident that we have in place a great team to help our users and the APS take fullest advantage of the APS-U opportunity. In planning with users for the proposed APS-U, we focused on the need to study 'real materials under real conditions in real time' on spatial and temporal scales unavailable today. Only by studying materials as they are made-or as they perform-in difficult environments can we solve the grand challenge of higher-performance, sustainable materials for energy and health. The proposed APS-U will improve the brightness of penetrating x-rays produced by the APS over 100 times, and support our efforts in developing state-of-the-art instruments to address these challenges.

Gibson, J. M; Mills, D. M.; Gerig, R.

2010-05-01

116

PRESS RELEASE / PRESS RELEASE / PRESS RELEASE A new Advanced Master degree  

E-print Network

in Technology & Industry" The Ecole Centrale Paris will train very high-level buyers (Paris, January 12, 2010) ­ From September 2010, the "Purchasing Manager in Technology and Industry" Advanced Master degree with an industrial, technological and international environment. This third cycle, accredited by the Conférence des

Bezerianos, Anastasia

117

Burning-rate behavior in aluminized wide-distribution AP composite propellants  

Microsoft Academic Search

Burning-rate behavior of aluminized, wide-distribution ammonium-perchlorate (AP), hydroxyl-terminated-polybutadiene (HTPB)\\u000a binder composite propellants, both 2D laminates and 3D particulate propellants, is investigated experimentally. Very fine\\u000a (2-m) AP (FAP) is used at a high FAP\\/binder ratio (75\\/25) with either coarse (>200 m) AP (CAP) particles (3D particulate\\u000a propellants) or pressed AP slabs (simulating CAP particles in over-ventilated, 2D laminates). The results indicate

M. Q. Brewster; J. C. Mullen

2011-01-01

118

AP Biology Demonstrations  

NSDL National Science Digital Library

A collection of experiments and demonstrations presented by biology teachers addressing some of the most difficult-to-understand topics in the AP biology curriculum which include evolutionary traits, genetics, bacterial transformation, antibody diversity, comparative anatomy, photosynthesis, human genetics, protein synthesis, recombinant DNA and RNA polymerase.

The College Board The College Board (The College Board;)

2003-06-03

119

Advancing beyond AP Courses  

ERIC Educational Resources Information Center

A quiet revolution is picking up steam in the nation's private secondary schools, with broad implications for college admissions and for teaching and learning on both sides of the transition from high school to college. About 50 of the nation's leading college-preparatory schools have opted out of the College Board's Advanced Placement (AP)

Hammond, Bruce G.

2009-01-01

120

MIT Press  

NSDL National Science Digital Library

The editors and staff of The MIT Press, invite you to browse through their on-line catalogues featuring recent books (1993-1994) and current journals. The MIT Press is one of the world's leading scholarly technical publishers, offering texts and monographs in the computational and cognitive sciences, architecture, photography, art and literary theory, economics, environmental science, and linguistics.

121

N-methyl- d-aspartate (NMDA)-mediated corticotropin-releasing factor (CRF) release in cultured rat amygdala neurons 1 1 Abbreviations used: CRF, corticotropin-releasing factor; NMDA, N-methyl- d-aspartate; AP5, 2-amino-5-phosphonovaleric acid; LC, locus coeruleus; DIC, days in culture  

Microsoft Academic Search

Corticotropin-releasing factor (CRF) plays an important role in the activation of centrally mediated responses to stress. The amygdala, a limbic structure involved in the stress response, has a significant number of CRF cell bodies and CRF receptors. Activation of glutamatergic projections to the amygdala has been implicated in the stress response. Few studies have evaluated neurotransmitter-stimulated CRF release in the

Michael S. Cratty; Dale L. Birkle

1999-01-01

122

Renal involvement in the antiphospholipid syndrome (APS)-APS nephropathy.  

PubMed

Although the kidney represents a major target organ in antiphospholipid syndrome (APS), renal involvement in APS was poorly recognized until recently. The most well-recognized renal manifestations of APS are the renal artery thrombosis/stenosis, renal infarction, hypertension, renal vein thrombosis, end-stage renal disease, increased allograft vascular thrombosis, some types of glomerular disease, and a small-vessel vaso-occlusive nephropathy, recently defined as APS nephropathy. APS nephropathy was first described in primary APS patients, characterized by acute thrombotic lesions in glomeruli and/or arterioles (thrombotic microangiopathy) and chronic vascular lesions such as fibrous intimal hyperplasia of arterioles and interlobular arteries, organized thrombi with or without recanalization, and fibrous arterial and arteriolar occlusions or focal cortical atrophy. APS nephropathy was also detected in further studies including patients with systemic lupus erythematosus (SLE)-related APS and SLE/non-APS patients with positive antiphospholipid antibodies, independently of lupus nephritis. The same histologic lesions, especially thrombotic mictroangiopathy, were also observed in patients with catastrophic APS. The most frequent clinical and laboratory characteristics of APS nephropathy in all the above groups of patients are hypertension (often severe), proteinuria (ranging from mild to nephrotic range), hematuria, and acute or chronic renal insufficiency. PMID:19048414

Tektonidou, Maria G

2009-06-01

123

Physics AP B II  

NSDL National Science Digital Library

HippoCampus, a project of the Monterey Institute for Technology and Education (MITE), seeks to provide âhigh-quality, multimedia content on general education subjects to high school and college students.â This course, Advanced Placement Physics B II, is part two of a two-semester course and contains study materials, lessons, interactive media, and textbooks to help students prepare for the College Board AP Physics exam. Three course units, containing nineteen chapters in total, cover topics in electrostatics, conductors and capacitors, electric circuits, magnostatics, electromagnetism, wave motion, physical optics, geometric optics, atomics physics and quantum effect, and nuclear physics. Many of the chapters feature multimedia resources that employ a variety of interactive activities to help students absorb information. This is an excellent self-paced tool for students to use while preparing for the AP Physics exam, or as supplementary material for a physics course.

2008-07-08

124

AP Biology I  

NSDL National Science Digital Library

Presented by HippoCampus, a project of The Monterey Institute for Technology and Education, this free online course covers all of the material outlined by the College Board as necessary to prepare students to pass the AP Biology exam and is designed to acquaint visitors with "the general concepts of life including reproduction, balance in nature, and the nature of living things." This section is the first of a two-semester AP Biology course and contains six units: Introduction to Biology; Cell Structure and Function; Genes; Principles of Heredity; Evolutionary Biology; and Biological Diversity. Each unit includes readings, lessons, and assignments and/or chapter tests with answers. The site also lists all the topics covered, indexed in both alphabetical and sequential order. It's a great place for students to get extra help in Biology and for instructors to find lecture and test materials for the classroom.

125

AP Biology II  

NSDL National Science Digital Library

Presented by Hippocampus, a project of The Monterey Institute for Technology and Education, this free online course covers all of the material outlined by the College Board as necessary to prepare students to pass the AP Biology exam and is designed to acquaint visitors with "the general concepts of life including reproduction, balance in nature, and the nature of living things." This section is the second of a two-semester AP Biology course and contains six units: Energetics of Life; Animal Structure, Reproduction, and Development; Circulation, Body's Defenses, Nutrition; Nervous System and Internal Controls; Plants: Form and Function; and Ecology. Each unit includes readings, lessons, and assignments and/or chapter tests with answers. The site also lists all the topics covered, indexed in both alphabetical and sequential order. It's a great place for students to get extra help in Biology and for instructors to find lecture and test materials for the classroom.

126

Supercomputing and Ap stars  

E-print Network

Certain problems in the field of stellar atmospheres, polarized radiative transfer and magnetic field diagnostics cannot be addressed by means of traditional sequential programming techniques because CPU times become prohibitive on even the fastest single processor machines when realistic physics and accurate numerical methods are employed. This contribution discusses the question of what kind of supercomputing approach is best suited for the modelling of Ap stars, pointing out the superiority of parallel computing with Ada95 over High Performance Fortran in all of the above-mentioned fields.

Martin J. Stift

1998-05-06

127

WordPress 3.1  

NSDL National Science Digital Library

Though commonly thought of as a type of blogging application, WordPress is much more than that. Recently, WordPress released a new version of their software that includes helpful new plugins (many created by their dedicated users) and themes. Visitors can use the tutorial on their site to learn about the many uses of WordPress, and they should also look through the "Extend" area to learn about the many different customizable options available here. This version of WordPress is compatible with all operating systems, including those running Linux.

Boren, Ryan; Mullenweg, Matt

2011-01-01

128

CRCHD - Press Kit  

Cancer.gov

CRCHD - Press Kit Home News and Events Press Kit Health Disparities News & Articles E-bulletin News Stories & Interviews CRCHD Spotlights Meetings & Events Press Kit Press Kit To support outreach in the community,

129

AP1 function and regulation  

Microsoft Academic Search

AP-1 (activating protein-1) is a collective term referring to dimeric transcription factors composed of Jun, Fos or ATF (activating transcription factor) subunits that bind to a common DNA site, the AP-1-binding site. As the complexity of our knowledge of AP-1 factors has increased, our understanding of their physiological function has decreased. This trend, however, is beginning to be reversed due

Michael Karin; Zheng-gang Liu; Ebrahim Zandi

1997-01-01

130

Michael Clay, MD AP-2 Resident  

E-print Network

Darren Salmi, MD AP-3 Resident Natalia Isaza, MD CP-1 Resident Adam Gomez, MD AP-1 Resident Karen Kunder, MD, PhD AP-3 Resident Jean Oak, MD, PhD AP-2 Resident Michael Ozawa, MD, PhD AP-1 Resident Ophir Vermesh, MD, PhD CP-1 Resident Gerlinde Wernig, MD AP-3 Resident Chris Soon, MD AP-2 Resident

Bogyo, Matthew

131

AP Calculus BC I  

NSDL National Science Digital Library

Presented by HippoCampus, a project of the Monterey Institute for Technology and Education, this free online course covers all of the material outlined by the College Board as necessary to prepare students to pass the AP Calculus BC exam. This course is divided into two semesters and this unit is the first of those two semesters, it is designed to "acquaint you with calculus principles such as derivatives, integrals, limits, approximation, applications and modeling, and sequences and series." The course is separated into four units, including functions and graphs, limits and continuity, derivatives, and application of the derivative. Each lesson has objectives, readings, multimedia lectures, and assessments with answers. The site is also indexed by subject, which can be browsed alphabetically or sequentially. It is a great place for students to enhance their calculus skills or for educators to find supplementary materials for the classroom.

2008-07-09

132

AP Physics C I  

NSDL National Science Digital Library

Presented by HippoCampus, a project of the Monterey Institute for Technology and Education, this free online course covers all of the material outlined by the College Board as necessary to prepare students to pass the AP Physics C exam. This course is divided into two semesters and this course is the first of those two semesters and is designed to acquaint you with topics in mechanics and classical electricity and magnetism. The first semester is devoted to Newtonian mechanics including: kinematics, laws of motion, work and energy, systems of particles, momentum, circular motion, oscillations, and gravitation. The second semester discusses the topics of electricity and magnetism. Each unit within the course has objectives, readings, lessons, response and discussion questions, as well as lab exercises. The site is also indexed by subject, which can be browsed alphabetically or sequentially. It is a great place for students to enhance their skills in physics or for educators to find supplementary materials for the classroom.

133

AP-42 REVISION: COKE OVENS  

EPA Science Inventory

The document "Compilation of Air Pollutant Emission Factors" (AP-42) has been published by the U. S. Environmental Protection Agency (EPA) since 1972. Supplements to AP-42 have been routinely published to add new emission source categories and to update existing emission factor...

134

A database of AP stars  

NASA Astrophysics Data System (ADS)

A database for 3195 Ap stars, which can be used on an IBM-compatible personal computer, is described. It is essentially based on Renson's general catalogue of Ap and Am stars, but contains much additional information. It operates within the Dbase III Plus system.

Renson, P.; Kobi, D.; North, P.

1991-07-01

135

2007 AP-S Graduate and Undergraduate Research Award Recipients Announced  

E-print Network

2007 AP-S Graduate and Undergraduate Research Award Recipients Announced C ongratulations to the spring and fall 2007 AP-S Graduate andUndergraduate Research Award recipients! These excellent students of the Education Column). AP-S Undergraduate Research Award Recipients Michael Carroll (Figure 2) Robert Parry

Gürel, Levent

136

APS controls overview  

SciTech Connect

The APS accelerator control system described in this report is a distributed system consisting of operator interfaces, a network, and interfaces to hardware. The operator interface is a UNIX-based workstation with an X-windows graphical user interface. The workstation may be located at any point on the facility network and maintain full functionality. The user has the ability to generate and alter control displays and to access the alarm handler, the archiver, interactive control programs, custom code, and other tools. The TCP/EP networking protocol has been selected as the underlying protocol for the control system network. TCP/EP is a commercial standard and readily available from network hardware vendors. Its implementation is independent of the particular network medium selected to implement the controls network. In the development environment copper Ethernet is the network medium; however, in the actual implementation a fiber-based system using hub technology will be utilized. The function of the network is to provide a generalized communication path between the host computers, operator workstations, input/output crates, and other hardware that comprise the control system.

NONE

1996-02-01

137

AP Physics C II  

NSDL National Science Digital Library

Presented by HippoCampus, a project of the Monterey Institute for Technology and Education, this free online course covers all of the material outlined by the College Board as necessary to prepare students to pass the AP Physics C exam. This course is divided into two semesters and this course is the second of those two semesters and is designed to acquaint you with topics in mechanics and classical electricity and magnetism. The first semester is devoted to Newtonian mechanics including: kinematics, laws of motion, work and energy, systems of particles, momentum, circular motion, oscillations, and gravitation. The second semester discusses the topics of electricity and magnetism. Each unit with in the course has objectives, readings, lessons, response and discussion questions, as well as lab exercises. The site is also indexed by subject, which can be browsed alphabetically or sequentially. It is a great place for students to enhance their skills in physics or for educators to find supplementary materials for the classroom.

138

APS Minority Travel Fellows Attend the 2010 APS Conferences  

NSDL National Science Digital Library

From The Physiologist. Four travel fellows received funding to attend the 2010 APS Intersociety Meeting, Global Change and Global Science: Comparative Physiology in a Changing World, from August 4-7, 2010 in Westminster, CO. Four travel fellows received funding to attend the APS Conference, Inflammation, Immunity and Cardiovascular Disease, from August 25-28, 2010 also in Westminster, CO. The application reviews were led by Committee Member, Johana Vallejo-Elias.

2010-12-01

139

Charles Darwin University Press  

E-print Network

CDU Press Catalogue Charles Darwin University Press (CDU Press) (GLWHG E\\ -XGH &RQZD\\ 6WHS E\\ 6WHS Wildflowers Graham Brown CHARLES DARWIN UNIVERSITY PRESS #12;1 2 Welcome to Our Catalogue CDU Press is the academic publisher based on the Casuarina Campus of Charles Darwin University, Northern Territory

140

Attacks on the Press in 2001  

NSDL National Science Digital Library

Released by the Committee to Protect Journalists (CPJ), a nonpartisan, nonprofit organization established to "monitor abuses against the press and promote press freedom around the world," Attacks on the Press 2001 documents the deaths, imprisonment, and abuses of journalists around the world within the past year. Prefaced by CPJ board member Anne Garrels with an introduction by CPJ's executive director Ann Cooper, the report contains an overview of media attacks arranged by country, along with three special press freedom reports on Syria, Burma, and Colombia. In addition, the report contains a Ten Worst Enemies of the Press section that focuses attention on individual leaders responsible for the world's worst abuses against the media. Topping the list are Supreme Leader Ayatollah Ali Khamenei of Iran, President Jiang Zemin of China, and Liberian president Charles Taylor.

2002-01-01

141

Attacks on the Press in 2000  

NSDL National Science Digital Library

This recently published survey reports on the harassment, imprisonment, and death of journalists worldwide. The report is comprised of regional overviews, country summaries, and individual documented cases. There are also special sections on journalists murdered or imprisoned in the last year, the International Press Freedom Awards of 2000 (given to courageous journalists), and a press release, as well as individual reports on the state of press freedom in China, Russia, and Venezuela. The report may be viewed in HTML or .pdf formats. Earlier editions of this annual report are also available on this site, back to 1996. The preface of this most recent edition was written by Peter Arnett.

2001-01-01

142

Lost City News Release  

NSDL National Science Digital Library

This press release from the National Science Foundation provides an overview of the 2003 expedition to the Lost City Hydrothermal Field at the Atlantis Massif. It briefly describes the expedition, features of the Lost City, research results and implications for future discoveries. Photos and images accompany the text.

Affairs, Office O.; Foundation, National S.

143

Multicomponent Implant Releasing Dexamethasone  

NASA Astrophysics Data System (ADS)

Several inflammatory conditions are usually treated with corticosteroids. There are various problems like side effects with traditional applications of steroids, e.g. topical, or systemic routes. Local drug delivery systems have been studied and developed to gain more efficient administration with fewer side effects. Earlier, we reported on developing Dexamethasone (DX) releasing biodegradable fibers. However, their drug release properties were not satisfactory in terms of onset of drug release. Thus, we assessed the development of multicomponent (MC) implant to enhance earlier drug release from such biodegradable fibers. Poly (lactide-co-glycolide) (PLGA) and 2 wt-% and 8 wt-% DX were compounded and extruded with twin-screw extruder to form of fibers. Some of the fibers were sterilized to obtain a change in drug release properties. Four different fiber classes were studied: 2 wt-%, 8 wt-%, sterilized 2 wt-%, and sterilized 8 wt-%. 34 different DX-releasing fibers were then heat-pressed to form one multicomponent rod. Half of the rods where sterilized. Drug release was measured from initial fibers and multicomponent rods using a UV/VIS spectrometer. Shear strength and changes in viscosity were also measured. Drug release studies showed that drug release commenced earlier from multicomponent rods than from component fibers. Drug release from multicomponent rods lasted from day 30 to day 70. The release period of sterilized rods extended from day 23 to day 57. When compared to the original component fibers, the drug release from MC rods commenced earlier. The initial shear strength of MC rods was 135 MPa and decreased to 105 MPa during four weeks of immersion in phosphate buffer solution. Accordingly, heat pressing has a positive effect on drug release. After four weeks in hydrolysis, no disintegration was observed.

Nikkola, L.; Vapalahti, K.; Ashammakhi, N.

2008-02-01

144

AP Chemistry Course Home Page  

NSDL National Science Digital Library

For people with a penchant for benzene rings and other topics, the AP Chemistry Course site is a great resource. Designed for both educators and students, the site contains resources for teaching to the AP exam as well as a wealth of other items. Interested parties should explore the Classroom Resources where they will find seven different lab activities, such as "Misconceptions and Issues in Quantum Theory" and "Women Scientists of the Manhattan Project.â Additionally, the site features Other Core Resources which includes an open forum for educators along with some basic overviews for crafting a one-semester course in chemistry.

145

AP Human Geography and Success on the AP Test  

ERIC Educational Resources Information Center

Classroom projects that explore culture and globalization enhance the curriculum and help students see how geography directly connects to their lives. These authors contend that a project-based approach can supplement the teaching of an AP Human Geography course, and visualize this course as an essential tool for students to truly understand how

Roncone, John; Newhalfen, Nate

2013-01-01

146

www.curia.europa.eu Press and Information  

E-print Network

www.curia.europa.eu Press and Information Court of Justice of the European Union PRESS RELEASE is contrary to the freedom of movement for citizens of the European Union. The disputes before those courts and the freedom of movement of citizens of the European Union preclude nation legislation which makes the award

Heermann, Dieter W.

147

Please cite this article in press as: A.P. Mller, et al., High frequency of albinism and tumours in free-living birds around Chernobyl, Mutat. Res.: Genet. Toxicol. Environ. Mutagen. (2013), http://dx.doi.org/10.1016/j.mrgentox.2013.04.019  

E-print Network

in free-living birds around Chernobyl, Mutat. Res.: Genet. Toxicol. Environ. Mutagen. (2013), http.elsevier.com/locate/mutres High frequency of albinism and tumours in free-living birds around Chernobyl A.P. Møllera, , A Keywords: Albinism Chernobyl Population decline Radiation Tumours a b s t r a c t The effects

Mousseau, Timothy A.

148

Cell Reports Dynamics of Intracellular Clathrin/AP1-  

E-print Network

Cell Reports Report Dynamics of Intracellular Clathrin/AP1- and Clathrin/AP3-Containing Carriers.09.025 SUMMARY Clathrin/AP1- and clathrin/AP3-coated vesicular carriers originate from endosomes and the trans/AP1 and cla- thrin/AP3 carriers are similar to those of endocytic clathrin/AP2 pits and vesicles

Kirchhausen, Tomas

149

AP Geography, Environmental Science Thrive  

ERIC Educational Resources Information Center

Geography may not be particularly known as a hot topic among today's students--even some advocates suggest it suffers from an image problem--but by at least one measure, the subject is starting to come into its own. Across more than 30 topics covered in the Advanced Placement (AP) program, participation in geography is rising faster than any

Robelen, Erik W.

2012-01-01

150

APS undergraduate brainstorming summit report  

NSDL National Science Digital Library

IN 2004, the Education Committee was charged with seeking additional strategies to increase the exposure of undergraduate students to physiology studies and careers. Following a reaffirmation of this charge in the 2006 strategic plan, the American Physiological Society (APS) hosted an undergraduate brainstorming summit in late September of 2006.

PhD Robert G. Carroll (East Carolina State University Department of Physiology); PhD Marsha L Matyas (American Physiological Society Education); Van Doze (University of North Dakota School of Medicine and Health Sciences Pharmacology, Physiology, and Therapeutics); PhD Richard Faircloth (Anne Arundel Community College Dept. of Biology); Patricia Finkenstadt (Phoenix College); PhD Barbara E. Goodman (University of South Dakota School of Medicine Division of Basic Biomedical Sciences)

2007-12-09

151

AP Management and Handover support  

E-print Network

AP Management and Handover support (802.11f) Renato Lo Cigno http Points Protocol ­ IAPP One in IEEE: 802.11f (already standard ... not much implemented ) mainly supports coordinated handovers, 802.11r (resource management), 802.11k (fast handover for vehicular applications) One

Lo Cigno, Renato Antonio

152

AP Management and Handover support  

E-print Network

AP Management and Handover support CapWap and 802.11f Renato Lo Cigno ­ Alessandro Villani www · Two main proposal for standardization of an Inter Access Points Protocol ­ IAPP · One in IEEE: 802.11f (already standard ... not much implemented ) mainly supports coordinated handovers, 802.11r (resource

Jain, Raj

153

AP Management and Handover support  

E-print Network

AP Management and Handover support (CAPWAP - 802.11f) Renato Lo Cigno http proposal for standardization of an Inter Access Points Protocol ­ IAPP n One in IEEE: 802.11f (already standard ... not much implemented L) mainly supports coordinated handovers, 802.11r (resource management

Lo Cigno, Renato Antonio

154

Iodine Volatility and pH Control in the AP600 Reactor  

Microsoft Academic Search

Two design-basis accidents for the AP-600 reactor are formulated and evaluate~ in which significant bypass of the principal;\\u000apH control system occurs. Some iodine released from the reactor primary system is retained in the Incontainment Refaeling;\\u000aWater Storage Tank (IRWST) water, never entering the containment where trisodium phosphate produces a high pH. Some;\\u000aof this iodine is volatilized and is

E. C. Beahm; C. F. Weber

1998-01-01

155

PRESS RELEASE On Friday November 1st  

E-print Network

was a result of a theft of cannabis that occurred earlier in the day during a drug transaction. Following the theft of cannabis, the victim in this theft summoned several acquaintances with Unlawful Delivery of Cannabis within a 1000 feet of a School (less than 10 grams) 11

Karonis, Nicholas T.

156

ITER Press Release Cadarache, 24 October 2007  

E-print Network

November 2006 the representatives of the People's Republic of China, EURATOM, the Republic of India, Japan on the 21 November 2006, when the representatives of Europe, Japan, China, India, the Republic of Korea challenging scientific undertaking of modern times: The ITER project. The idea for ITER originated from

157

Press Release 3rd December 2012  

E-print Network

François-Alphonse Forel, limnology, or the study of lakes, is returning to its roots. On December 3, 2012, EPFL inaugurates the Margaretha Kamprad Chair in limnology and environmental science, in the presence. Alfred Wüest, a world renowned expert in aquatic physics, has been nominated to hold the Chair. Limnology

Wehrli, Bernhard

158

MATHEMATICS OF PLANET EARTH PRESS RELEASE  

E-print Network

Union and UNESCO is also the European launch of MPE2013. "The MPE2013 and stimulating research, says Marta Sanz-Solé, President of the European Mathematical for contemporary art will also be presented. The MPE Day will end

159

HangarBicocca, Milan Press Release  

E-print Network

and Lindstrand Technologies, a leading company in the research and production of aerostatic materials the limitations of physics through the experimentation of materials and techniques never used before. The outcome corporate history ­ ever open to innovation ­ on the constant dialectic between the rigor of technological

160

Press Release Date: Wednesday 5 February 2014  

E-print Network

aesthetic that the musicians/artists we work with are aware of. There is no fixed process in regards suggest images they want to use, or drawings of theirs they would like translated into the PVC design

Stell, John

161

Press Release Date: Wednesday 5 February 2014  

E-print Network

Leeds Communities and The Tetley through social design. Tetley Feast is an exhibition of collaborative-3.30pm and 5-8pm. Refreshments are provided. The Tetley Feast is a collaborative project between Leeds design. The Tetley Feast culminates at The Tetley on 12th February where work which was produced

Stell, John

162

Press Release Graduate Entrepreneurship Boot Camp  

E-print Network

WIRE Young Entrepreneur of the Year 2012, Ben Allen, whose Scarborough-based business provides activities vote for `Best Pitch' and the panel judged him as having `Best Product', said `Bootcamp, gave me the ability and opportunity to mix and work with a variety of different business minded people from a huge

Stell, John

163

TABLE OF CONTENTS Press Release p.2  

E-print Network

, as well as natural resource conservation, farm biodiversity, and alternative energy. For more information and History p.4 Conference Activities and Events p.5 Registration Information p.6 Publicity Blurb p.7 Thank you for your interest in the 2013 Florida Small Farms and Alternative Enterprises Conference! We hope

Watson, Craig A.

164

TABLE OF CONTENTS Press Release p.2  

E-print Network

, as well as natural resource conservation, farm biodiversity, and alternative energy. For more information and History p.4 Conference Activities and Events p.5 Registration Information p.6 Publicity Blurb p.7 Thank you for your interest in the 2014 Florida Small Farms and Alternative Enterprises Conference! We hope

Jawitz, James W.

165

Enhanced Antimicrobial Activity of AamAP1-Lysine, a Novel Synthetic Peptide Analog Derived from the Scorpion Venom Peptide AamAP1  

PubMed Central

There is great interest in the development of antimicrobial peptides as a potentially novel class of antimicrobial agents. Several structural determinants are responsible for the antimicrobial and cytolytic activity of antimicrobial peptides. In our study, a new synthetic peptide analog, AamAP1-Lysine from the naturally occurring scorpion venom antimicrobial peptide AamAP1, was designed by modifying the parent peptide in order to increase the positive charge and optimize other physico-chemical parameters involved in antimicrobial activity. AamAP1-Lysine displayed potent antibacterial activity against Gram-positive and Gram-negative bacteria. The minimum inhibitory concentration was in the range of 5 to 15 M with a 10 fold increase in potency over the parent peptide. The hemolytic and antiproliferative activity of AamAP1-Lysine against eukaryotic mammalian cells was minimal at the concentration range needed to inhibit bacterial growth. The antibacterial mechanism analysis indicated that AamAP1-Lysine is probably inducing bacterial cell death through membrane damage and permeabilization determined by the release of ?-galactosidase enzyme from peptide treated E. coli cells. DNA binding studies revealed that AamAP1-Lysine caused complete retardation of DNA migration and could display intracellular activities in addition to the membrane permeabilization mode of action reported earlier. In conclusion, AamAP1-Lysine could prove to be a potential candidate for antimicrobial drug development in future studies. PMID:24776889

Almaaytah, Ammar; Tarazi, Shadi; Abu-Alhaijaa, Ahmad; Altall, Yara; Alshari, Nizar; Bodoor, Khaldon; Al-Balas, Qosay

2014-01-01

166

ASSESSING CHEMICAL RELEASES AND WORKER EXPOSURES FROM A FILTERPRESS  

EPA Science Inventory

Chemical releases and worker exposures associated with the filtration of an industrial wastewater sludge were characterized. The filter was a recessed chamber filter press with an open filtrate discharge system. Chemical releases and worker exposures for a selected chemical were ...

167

Preparing Students for the AP Psychology Exam  

ERIC Educational Resources Information Center

The Advanced Placement Psychology exam is one of the fastest growing exams offered by the College Board. The average percent of change in the number of students taking this exam over the past five years is 12.4%. With 238,962 students taking the exam in 2013, the AP Psychology exam is the sixth largest exam, surpassing AP Biology and AP World

Whitlock, Kristin

2013-01-01

168

Detecting protected layer-3 rogue APs  

Microsoft Academic Search

Unauthorized rogue access points (APs), such as those brought into a corporate campus by employees, pose a security threat as they may be poorly managed or insufficiently secured. Any attacker in the vicinity can easily get onto the internal network through a rogue AP, bypassing all perimeter security measures. Existing detection solutions work well for detecting layer-2 rogue APs. It

Hongda Yin; Guanling Chen; Jie Wang

2007-01-01

169

Molecular evolution of the AP2 subfamily.  

PubMed

The AP2 (APETALA2)/EREBP (Ethylene Responsive Element Binding Protein) multigene family includes developmentally and physiologically important transcription factors. AP2/EREBP genes are divided into two subfamilies: AP2 genes with two AP2 domains and EREBP genes with a single AP2/ERF (Ethylene Responsive Element Binding Factor) domain. Based on previous phylogenetic analyses, AP2 genes can be divided into two clades, AP2 and ANT groups. To clarify the molecular evolution of the AP2 subfamily, we isolated and sequenced genes with two AP2 domains from three gymnosperms, Cycas revoluta, Ginkgo biloba, and Gnetum parvifolium,as well as from the moss Physcomitrella patens. Expressions of AP2-like genes, including AP2, in Arabidopsis thaliana are regulated by the microRNA miR172. We found that the target site of miR172 is significantly conserved in gymnosperm AP2 homologs, suggesting that regulatory mechanisms of gene expression using microRNA have been conserved over the three hundred million years since the divergence of gymnosperm and flowering plant lineages. We inferred a phylogenetic relationship of these genes with the green alga Chlamydomonas reinhardtii and seed-plant genes available in public DNA databases. The phylogenetic tree showed that the AP2 subfamily diverged into the AP2 and ANT groups before the last common ancestor of land plants and after C. reinhardtii diverged from the land-plant lineage. The tree also indicated that each AP2 and ANT group further diverged into several clades through gene duplications prior to the divergence of gymnosperms and angiosperms. PMID:16388920

Shigyo, Mikao; Hasebe, Mitsuyasu; Ito, Motomi

2006-02-01

170

Press release For Immediate Release Seattle, USA. June 6, 2008  

E-print Network

costs for fossil fuels, it has increasingly become possible for power plants to also utilize higher-cost as a substitute for fossil fuels. Bi-products from sawmills have historically been the most commonly used wood costly 15,000- kilometer journey from the Interior of British Columbia to the European market

171

Nano Science and Technology Institute search Go Home | Subscribe | Site Map ABOUT | COURSES | EVENTS | PUBLICATIONS | MEMBERSHIP | LEADERSHIP | OUTREACH | NEWS | PRESS | JOBS Nanotechnology Solutions  

E-print Network

Press Press Releases About Search Engines Free Publicity PR Writing Tips RSS Feed Order Now! Press PressNano Science and Technology Institute search Go Home | Subscribe | Site Map ABOUT | COURSES, industrial and biomedical engineering. The team is being led by Rodrigo Martinez, Diana Davila, Juan Pablo

Chiao, Jung-Chih

172

APS Presents Awards at 2008 ABRCMS Conference  

NSDL National Science Digital Library

This is an article in The Physiologist. APS Presents Awards at Annual ABRCMS Conference APS/NIDDK Minority Travel Fellows Attend the 2008 APS Intersociety Meeting: The Integrative Biology of Exercise Education Special Sessions at Experimental Biology 2009 -------------------------------------------------------------------------------- APS Presents Awards at Annual ABRCMS Conference The APS presented awards to minority undergraduate researchers and was a major conference sponsor at the Annual Biomedical Research Conference for Minority Students (ABRCMS) at Disneys Coronado Springs Resort, Lake Buena Vista, FL from November 5-9, 2008.

2009-02-01

173

The APS control system network  

SciTech Connect

The APS accelerator control system is a distributed system consisting of operator interfaces, a network, and computer-controlled interfaces to hardware. This implementation of a control system has come to be called the {open_quotes}Standard Model.{close_quotes} The operator interface is a UNDC-based workstation with an X-windows graphical user interface. The workstation may be located at any point on the facility network and maintain full functionality. The function of the network is to provide a generalized communication path between the host computers, operator workstations, input/output crates, and other hardware that comprise the control system. The crate or input/output controller (IOC) provides direct control and input/output interfaces for each accelerator subsystem. The network is an integral part of all modem control systems and network performance will determine many characteristics of a control system. This paper will describe the overall APS network and examine the APS control system network in detail. Metrics are provided on the performance of the system under various conditions.

Sidorowicz, K.V.; McDowell, W.P.

1995-12-31

174

The APS in Public Affairs  

NASA Astrophysics Data System (ADS)

Although the American Physical Society was created for the interchange of scientific ideas, the call to the founding meeting included the observation that the organization "could not fail to have an important influence in all matters affecting the interest of physicists". However for most of its history APS did not behave like "just another interest group in American society". Instead, at the beginning, it limited itself to such successful initiatives as the creation of the Bureau of Standards and such unsuccessful ones as adoption of the metric system. After World War II, speaking out on behalf of the freedom of science and scientists, such as Astin, Condon, and Oppenheimer, became important. In the 1970's, pushed by members, the Society became more "political", sponsoring sessions and studies on defense issues, taking a stand for the Equal Rights Amendment and creating the Panel on Public Affairs and the Forum on Physics and Society. Only in the last fifteen years has the APS unabashedly lobbied for the economic interests of physics and physicists. Adopting this new, if unavoidable role may have unintended consequences for the willingness and effectiveness of APS in speaking out on other public issues.

Lustig, Harry

2000-04-01

175

Dynamics of intracellular clathrin/AP1 and clathrin/AP3 containing carriers  

PubMed Central

Clathrin/AP1 and clathrin/AP3 coated vesicular carriers originate from endosomes and the TGN. We report here the real-time visualization of these structures in living cells reliably tracked by using rapid, three-dimensional imaging with a spinning-disk confocal microscope. We imaged relatively sparse, diffraction-limited, fluorescent objects containing chimeric fluorescent protein (clathrin light chain, ? adaptor subunits or dynamin2) with a spatial precision of up to ~ 30 nm and a temporal resolution of ~ 1 sec. The dynamic characteristics of the intracellular clathrin/AP1 and clathrin/AP3 carriers are similar to those of endocytic clathrin/AP2 pits and vesicles; the clathrin/AP1 coats are, on average, slightly shorter-lived than their AP2 and AP3 counterparts. We confirmed that while dynamin2 is recruited as a burst to clathrin/AP2 pits immediately before their budding from the plasma membrane, we found no evidence supporting a similar association of dynamin2 with clathrin/AP1 or clathrin/AP3 carriers at any stage during their lifetime. We found no effects of chemical inhibitors of dynamin function or the K44A dominant negative mutant of dynamin on AP1 and AP3 dynamics. This observation suggests that an alternative budding mechanism, yet to be discovered, is responsible for the scission step of clathrin/AP1 and clathrin/AP3 carriers. PMID:23103167

Kural, Comert; Tacheva-Grigorova, Silvia K.; Boulant, Steeve; Cocucci, Emanuele; Baust, Thorsten; Duarte, Delfim; Kirchhausen, Tom

2012-01-01

176

AP reclamation and reuse in RSRM propellant  

NASA Technical Reports Server (NTRS)

A solid propellant ingredient reclamation pilot plant has been evaluated at the Strategic Operations of Thiokol Corporation, located in Brigham City, Utah. The plant produces AP wet cake (95 percent AP, 5 percent water) for recycling at AP vendors. AP has been obtained from two standard propellant binder systems (PBAN and HTPB). Analytical work conducted at Thiokol indicates that the vendor-recrystallized AP meets Space Shuttle propellant specification requirements. Thiokol has processed 1-, 5-, and 600-gallon propellant mixes with the recrystallized AP. Processing, cast, cure, ballistic, mechanical, and safety properties have been evaluated. Phillips Laboratory static-test-fired 70-pound and 800-pound BATES motors. The data indicate that propellant processed with reclaimed AP has nominal properties.

Miks, Kathryn F.; Harris, Stacey A.

1995-01-01

177

CDC Releases Report on 30-Year Low in Youth Homicide Rates  

MedlinePLUS

... 2013 at 5pm ET Contact: Division of News & Electronic Media , Office of Communication (404) 639-3286 CDC ... Press Materials News Releases Digital Press Kit 2013 Archive 2012 Archive Features Have You Heard? 2013 Archive ...

178

The Global University Press  

ERIC Educational Resources Information Center

The modern world's understanding of American university press has long been shaped by university-press books. American university-press books are good international advertisements for the universities whose logos grace their spines. The growth of transnational scholarship and the expansion of digital communications networks are converging in ways

Dougherty, Peter J.

2012-01-01

179

Microstructural changes produced by annealing in particles of industrial APS1, APS2, AND APS3 aluminum powders  

Microsoft Academic Search

1.During annealing in the air on in an argon atmosphere, nodulized particles of industrial APS-1, APS-2, and APS-3 aluminum powders crack and acquire internal porosity.2.On heating in the air at 600 and 650C, aluminum powder undergoes oxidation and the ?-Al2O3 crystals present in it increase in size. Heating in an argon atmosphere is also accompanied by oxidation, which is due

A. I. Litvintsev; K. V. Ivashko; L. N. Klimova

1970-01-01

180

Doppler Imaging of Ap Stars  

E-print Network

Doppler imaging, a technique which inverts spectral line profile variations of an Ap star into a two-dimensional abundance maps, provides new observational constraints on diffusion mechanism in the presence of a global magnetic field. A programme is presented here with the aim to obtain abundance distributions of at least five elements on each star, in order to study how different diffusion processes act under influence of a stellar magnetic field. The importance of this multi-element approach is demonstrated, by presenting the abundance maps of helium, magnesium, silicon, chromium and iron for the magnetic B9pSi star CU Virginis.

R. Kuschnig

1998-05-06

181

ELECTROCHEMICAL CORROSION TESTING OF TANKS 241-AN-102 & 241-AP-107 & 241-AP-108 IN SUPPORT OF ULTRASONIC TESTING  

SciTech Connect

This report presents the results of the corrosion rates that were measured using electrochemical methods for tanks 241-AN-102 (AN-102), 241-AP-107 (AP 107), and 241-AP-108 (AP-108) performed under test plant RPP-PLAN-38215. The steel used as materials of construction for AN and AP tank farms was A537 Class 1. Test coupons of A537 Class 1 carbon steel were used for corrosion testing in the AN-107, AP-107, and AP-108 tank waste. Supernate will be tested from AN-102, AP-107, and Ap-108. Saltcake testing was performed on AP-108 only.

WYRWAS RB; DUNCAN JB

2008-11-20

182

1 The birth of the MIT Press The MIT Press  

E-print Network

1 The birth of the MIT Press The MIT Press celebrating 50 years #12;3 The birth of the MIT Press birth of the MIT Press #12;3the birth of the MIT Press Like its extraordinary home institution, the MIT with some memory intact at the time when the Institute gave birth to it. A look at correspondence

Polz, Martin

183

APS high heat load monochromator  

SciTech Connect

This document contains the design specifications of the APS high heat load (HHL) monochromator and associated accessories as of February 1993. It should be noted that work is continuing on many parts of the monochromator including the mechanical design, crystal cooling designs, etc. Where appropriate, we have tried to add supporting documentation, references to published papers, and calculations from which we based our decisions. The underlying philosophy behind performance specifications of this monochromator was to fabricate a device that would be useful to as many APS users as possible, that is, the design should be as generic as possible. In other words, we believe that this design will be capable of operating on both bending magnet and ID beamlines (with the appropriate changes to the cooling and crystals) with both flat and inclined crystal geometries and with a variety of coolants. It was strongly felt that this monochromator should have good energy scanning capabilities over the classical energy range of about 4 to 20 keywith Si (111) crystals. For this reason, a design incorporating one rotation stage to drive both the first and second crystals was considered most promising. Separate rotary stages for the first and second crystals can sometimes provide more flexibility in their capacities to carry heavy loads (for heavily cooled first crystals or sagittal benders of second crystals), but their tuning capabilities were considered inferior to the single axis approach.

Lee, W.K.; Mills, D.

1993-02-01

184

Firefly luciferase synthesizes P1,P4-bis(5'-adenosyl)tetraphosphate (Ap4A) and other dinucleoside polyphosphates.  

PubMed

The synthesis of P1,P4-bis(5'-adenosyl)tetraphosphate (Ap4A) has been considered, for a long time, to be catalyzed mainly by some aminoacyl-tRNA synthetases [Brevet et al. (1989) Proc. Natl. Acad. Sci. USA 86, 8275-8279]. Recently, yeast Ap4A phosphorylase, acting in reverse (Guranowski et al. (1988) Biochemistry 27, 2959-2964), was shown to synthesize Ap4A, too. In the case of the synthetases, the intermediate complex E-aminoacyl-AMP may serve as donor of AMP to ATP, yielding Ap4A. Here we demonstrate that firefly luciferase (EC 1.13.12.7) which forms the E-luciferin-AMP intermediate also synthesizes Ap4A as well as other dinucleoside polyphosphates. We suggest moreover that: other enzymes (mainly synthetases and some transferases), which catalyze the transfer of a nucleotidyl moiety, via nucleotidyl-containing intermediates and releasing PPi may produce dinucleoside polyphosphates. PMID:2172002

Guranowski, A; Sillero, M A; Sillero, A

1990-10-01

185

RESEARCH PUBLICATIONS A.P.S. Selvadurai  

E-print Network

nd Canadian Geotechnical Conference, Quebec City, pp.2.154-2.172. 9. Selvadurai, A.P.S., Bauer, G Conference, Quebec City, pp.2.211-2.224. #12;10. Selvadurai, A.P.S. (1979) The flexure of a uniformly loaded

Barthelat, Francois

186

Advanced Placement Program: What's Changing in AP  

NSDL National Science Digital Library

The AP Program has recently redesigned several courses in science, history, and world languages in an effort to stay strongly aligned with college credit policies and to prepare students for future learning and career pursuit. This website focuses on informing AP teachers about what's changing in AP, from course scope to exam preparation. The AP Chemistry revision will take effect in Fall, 2013. The change that will impact physics teachers most directly is the replacement of AP Physics B with two new year-long courses: AP Physics 1 Algebra-Based and AP Physics 2 Algebra-Based (scheduled to be deployed Fall, 2014). The changes to each course were guided by National Research Council and National Science Foundation recommendations, following several years of collaborations among university educators and master AP teachers. Especially noteworthy are the changes that integrate science practice as an essential component of the curriculum, along with statements that pair the essential knowledge (learning goal) to the appropriate science practice and articulate specific performance objectives.

2012-12-26

187

AP-42 ADDITIONS AND REVISIONS - WILDLAND FIRES  

EPA Science Inventory

This project is aimed at consolidating, selecting, and disseminating the most appropriate data and methods for estimating air emissions from wildfires and prescribed burns. The product will replace a current section of AP-42, but may not take the precise form of an AP-42 secti...

188

The status of APS, BESSRC, and NEET.  

SciTech Connect

We present a brief summary of the current status of the Advanced Photon Source (APS) at Argonne National Laboratory and of the facilities at two of the APS sectors operated by the Basic Energy Sciences Synchrotrons Radiation Center (BESSRC). This is followed by a report on recent measurements at BESSRC on the phenomenon of Nuclear Excitation by Electronic Transition (NEET).

Ahmad, I.; Dunford, R. W.; Esbensen, H.; Gemmell, D. S.; Kanter, E. P.; Kraessig, B.; Rutt, U.; Southworth, S. H.

1999-03-10

189

55. QUARRY TILE CUTTERS, SECOND FLOOR, NORTH WING. WORKERS PRESSED ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

55. QUARRY TILE CUTTERS, SECOND FLOOR, NORTH WING. WORKERS PRESSED THE CUTTERS INTO SLABS OF CLAY, LIFTED THEM ONTO DRYING BOARDS AND PRESSED THE PLUNGERS TO RELEASE THE CUT TILES. REPRODUCTIONS CUTTERS ARE NOT USED IN PRODUCTION. WOODEN FORMS FOR PRODUCING CLAY SLABS WITH ROLLING PINS REST AGAINST THE WALL. - Moravian Pottery & Tile Works, Southwest side of State Route 313 (Swamp Road), Northwest of East Court Street, Doylestown, Bucks County, PA

190

Combustion Response of AP Composite Propellants  

NASA Technical Reports Server (NTRS)

The Cohen & Strand model for AP composite propellants is applied as boundary conditions, one for AP and one for binder, in solving the heat conduction equation in each to compute linear and non-linear combustion response properties for each and for the aggregate propellant. Iterations couple AP and binder through the quasi-steady flame processes. Illustrative results for linear response functions (pressure-coupled and velocity-coupled) are presented for a monomodal AP propellant varying AP size, pressure and crossflow speed, and examples of non-linear responses to arbitrary waveforms are shown. A quantitative comparison with response function data is limited to one well-characterized research formulation. Mechanistic implications are discussed, including recommendations for future modeling work.

Shusser, Michael; Cohen, Norman S.; Culick, E. C.

2000-01-01

191

Observational studies of roAp stars  

NASA Astrophysics Data System (ADS)

Rapidly oscillating Ap (roAp) stars are high-overtone, low-degree p-mode pulsators that are also chemically peculiar magnetic A stars. Until recently the classical asteroseismic analysis i.e. frequency analysis, of these stars was based on ground and space photometric observations. Significant progress was achieved through access to uninterrupted, ultra-high-precision data from MOST, COROT and Kepler satellites. Over the last ten years the study of roAp stars has been altered drastically from an observational point of view through studies of time-resolved, high-resolution spectra. Their unusual pulsational characteristics, caused by an interplay between the short vertical lengths of the pulsation waves and strong stratification of chemical elements, allow us to examine the upper roAp atmosphere in more detail than is possible for any star except the Sun. In this paper I review the results of recent studies of the pulsations of roAp stars.

Sachkov, M.

2014-11-01

192

Role of AP1 and Gadkin in the traffic of secretory endo-lysosomes  

PubMed Central

Whereas lysosome-related organelles (LRO) of specialized cells display both exocytic and endocytic features, lysosomes in nonspecialized cells can also acquire the property to fuse with the plasma membrane upon an acute rise in cytosolic calcium. Here, we characterize this unconventional secretory pathway in fibroblast-like cells, by monitoring the appearance of Lamp1 on the plasma membrane and the release of lysosomal enzymes into the medium. After sequential ablation of endocytic compartments in living cells, we find that donor membranes primarily derive from a late compartment, but that an early compartment is also involved. Strikingly, this endo-secretory process is not affected by treatments that inhibit endosome dynamics (microtubule depolymerization, cholesterol accumulation, overexpression of Rab7 or its effector Rab-interacting lysosomal protein [RILP], overexpression of Rab5 mutants), but depends on Rab27a, a GTPase involved in LRO secretion, and is controlled by F-actin. Moreover, we find that this unconventional endo-secretory pathway requires the adaptor protein complexes AP1, Gadkin (which recruits AP1 by binding to the ?1 subunit), and AP2, but not AP3. We conclude that a specific fraction of the AP2-derived endocytic pathway is dedicated to secretory purposes under the control of AP1 and Gadkin. PMID:21525240

Laulagnier, Karine; Schieber, Nicole L.; Maritzen, Tanja; Haucke, Volker; Parton, Robert G.; Gruenberg, Jean

2011-01-01

193

77 FR 24480 - Application for New Awards; Advanced Placement (AP) Test Fee Program-Reopening the AP Test Fee...  

Federal Register 2010, 2011, 2012, 2013

...Reopening the AP Test Fee Fiscal Year 2012 Competition AGENCY: Office of Elementary and Secondary...reopening the AP Test Fee fiscal year 2012 competition...AP Test Fee fiscal year (FY) 2012 competition (February 15 notice). That...

2012-04-24

194

Development of the AP Technology Through Time  

NASA Astrophysics Data System (ADS)

This article presents the historical development of the AP Technology (Aluval, Voreppe, France) pot series starting with the AP13 in the 1960s, followed by the AP18 and the AP30 in the 1980s and 1990s. For most of the modern-era technology, from the late 1970s on, development has been based on a three-stage pattern, the first one being the pot modeling, followed by the pot prototype stage, and then the industrial stage, which fully validated the technology. This development pattern has proven to be successful since it has led to the very robust AP Technology pot design generation and a large number of greenfield smelters built in the 1990-2010 selected the AP Technology design. AP60 is the latest of this series: The development at the prototype level was initiated in the 1990s and is presented in the article. It is now followed by the first industrial realization at Jonquire with the startup in late 2013 and the full validation of the technology in mid-2014. The development of APXe, which aims at very low energy consumption, uses many common elements pertaining to the AP60 design and is presented in the article. AP Technology has also addressed the need for continuous and fast improvement of pot performances adapted to each existing client or site specifics; for this purpose, a new development methodology has recently emerged thanks to the very high modeling capabilities. This methodology, based on the validation of "technology bricks" and their integration in the final design following a strict process, is presented in the last section of this article.

Charmier, F.; Martin, O.; Gariepy, R.

2015-01-01

195

The A&P Professor  

NSDL National Science Digital Library

Kevin Patton is the president emeritus of the Human Anatomy and Physiology Society (HAPS) and he is also the brains behind the A&P (Anatomy & Physiology) Professor website. Patton has worked to create this online collection of resources for people teaching human anatomy and physiology, and it's a great counterpart to his blog of the same name. Visitors should start by looking over one of the five tabs at the top of the page, which include Resources, Topics, and How To. The How To contains resources for educators about producing online lectures and various in-class student response systems. The files here are dynamic, and they include interactive sections that make the material quite lively. Moving on, the Resources area includes an online version of an anatomy & physiology textbook created by Patton, along with links to other high-quality resources. Finally, the Lion's Den section of the site contains links to Patton's syllabi, course handouts, and a range of introductory materials for anyone who might be teaching a basic anatomy & physiology course.

Patton, Kevin T.

2012-04-06

196

32 CFR 635.11 - Release of information under the Freedom of Information Act (FOIA).  

Code of Federal Regulations, 2010 CFR

...true Release of information under the Freedom of Information Act (FOIA). 635...11 Release of information under the Freedom of Information Act (FOIA). ...b) FOIA requests from members of the press will be coordinated with the...

2010-07-01

197

32 CFR 635.11 - Release of information under the Freedom of Information Act (FOIA).  

Code of Federal Regulations, 2011 CFR

...false Release of information under the Freedom of Information Act (FOIA). 635...11 Release of information under the Freedom of Information Act (FOIA). ...b) FOIA requests from members of the press will be coordinated with the...

2011-07-01

198

32 CFR 635.11 - Release of information under the Freedom of Information Act (FOIA).  

Code of Federal Regulations, 2013 CFR

...false Release of information under the Freedom of Information Act (FOIA). 635...11 Release of information under the Freedom of Information Act (FOIA). ...b) FOIA requests from members of the press will be coordinated with the...

2013-07-01

199

32 CFR 635.11 - Release of information under the Freedom of Information Act (FOIA).  

...true Release of information under the Freedom of Information Act (FOIA). 635...11 Release of information under the Freedom of Information Act (FOIA). ...b) FOIA requests from members of the press will be coordinated with the...

2014-07-01

200

32 CFR 635.11 - Release of information under the Freedom of Information Act (FOIA).  

Code of Federal Regulations, 2012 CFR

...true Release of information under the Freedom of Information Act (FOIA). 635...11 Release of information under the Freedom of Information Act (FOIA). ...b) FOIA requests from members of the press will be coordinated with the...

2012-07-01

201

Four Theories of the Press.  

ERIC Educational Resources Information Center

A systematic understanding of the press requires an understanding of the social and political structures within which the press operates. This book discusses four theories that have determined the kind of press the Western world has had: authoritarian, libertarian, socially responsible, and Soviet communist. Each chapter discusses press

Siebert, Fred S.; And Others

202

Press laws in North Korea  

Microsoft Academic Search

The press in the Democratic People's Republic of Korea (North Korea) is closely tied to its communist sociopolitical structures. The North Korean press finds its modus operandi in the Soviet Communist theory for its relationship with its government. This study examines the press laws and regulations in North Korea, pursuing three questions: (1) What is the status of the press

Kyu Ho Youm

1991-01-01

203

The Press Freedom Database  

NSDL National Science Digital Library

Developed by the Committee to Protect Journalists (CPJ), The Press Freedom Database contains case histories of documented press freedom violations against journalists and media organizations worldwide as well as annual CPJ reports on the violations in specific countries and regions. The case histories document the circumstances in which journalists have been attacked, killed, expelled, censored, harassed, threatened, and/or imprisoned. The database is searchable by journalist name, news organization, type of organization, date, country, or region. Currently, the database, which is updated weekly, contains over 2,000 reports of press freedom violations, spanning from 1993 to the present.

204

APS Council Holds Fall Council Meeting  

NSDL National Science Digital Library

This is an article from The Physiologist. The APS Council held their fall meeting at the Scottsdale Marriott at McDowell Mountains, Scottsdale, AZ, November 8-9, 2007. Council received reports from the Publications, Finance, Membership, Education, and other Committees. APS staff members Marsha Matyas, Robert Price, Alice Ra?anan, and Margaret Reich joined the meeting to assist with the committee report presentations.

2008-02-01

205

Simplified SBLOCA Analysis of AP1000  

Microsoft Academic Search

The AP1000 is a 1000 MWe advanced nuclear power plant design that uses passive safety features such as a multi-stage, automatic depressurization system (ADS) and gravity-driven, safety injection from core make-up tanks (CMTs) and an in-containment refueling water storage tank (IRWST) to mitigate SBLOCA events. The period of most safety significance for AP1000 during a SBLOCA event is typically associated

William L

2004-01-01

206

Michigan State University Press  

E-print Network

Michigan State University Press FALL/ WINTER 2013 #12;MICHIGANSTATEUNIVERSITYPRESS This symbol:PALEOLITHICANIMALART.CAVELIONSATGROTTECHAUVET.PHOTO:DONHITCHCOCKFROMANIMALSASNEIGHBORS. INSIDECOVERIMAGE:STENAANECHRISTINE.BORNINDENMARKOCTOBER26,1864.SHEWASARESIDENTOFDIXON,AKENTCOUNTY,MICHIGAN,COMMUNITYCLOSETOTHEDANISHSETTLEMENTOF TRUFANTINMONTCALMCOUNTY.COURTESYOFTHEFLATRIVERHISTORICALSOCIETY,GREENVILLE,MICHIGAN,FROMDANESANDICELANDERSINMICHIGAN. NEW

Liu, Taosheng

207

Characteristics of AP bias in spin valve memory elements  

Microsoft Academic Search

Spin valve memory element biased with a pair of antiparallel (AP) coupled ferromagnetic layer was analyzed and modeled via micromagnetic simulation. In an AP structure, an external field results in a torque, causing the antiparallel magnetization (AP) axis to rotate towards the direction orthogonal to the field. In addition, due to its strength difference between the two AP layers, the

Jian-Gang Zhu; Youfeng Zheng

1998-01-01

208

EPICS release 3.11 specific documentation -- EPICS release notes for 3.11  

SciTech Connect

EPICS release 3.11 is now ready for user testing. A person who wants to set up a simplified application environment to boot an IOC and create databases using R3.11 should follow the directions in Appendix B, page 27, of the EPICS Source/Release Control Manual, Sept. 20, 1993. The R3.11 EPICS path at ANL/APS is /net/phebos/epics/R3.11 so the command to get the new release is /net/phebos/epics/R3.11/Unix/share/bin/getrel /net/phebos/epics/R3.11. An existing R3.8 short form report can be copied to this new directory and used to create a database. ANL/APS is currently testing an Application Developers Source/Release control system. It is not yet ready for general distribution. Attached are the EPICS R3.11 release notes.

NONE

1994-01-19

209

Ectopic expression of FaesAP3, a Fagopyrum esculentum (Polygonaceae) AP3 orthologous gene rescues stamen development in an Arabidopsis ap3 mutant.  

PubMed

Arabidopsis thaliana APETALA3 (AP3) and Antirrhinum majus DEFICIENS (DEF) MADS box genes are required to specify petal and stamen identity. AP3 and DEF are members of the euAP3 lineage, which arose by gene duplication coincident with radiation of the core eudicots. In order to investigate the molecular mechanisms underlying organ development in early diverging clades of core eudicots, we isolated and identified an AP3 homolog, FaesAP3, from Fagopyrum esculentum (buckwheat, Polygonaceae), a multi-food-use pseudocereal with healing benefits. Protein sequence alignment and phylogenetic analyses revealed that FaesAP3 grouped into the euAP3 lineage. Expression analysis showed that FaesAP3 was transcribed only in developing stamens, and differed from AP3 and DEF, which expressed in developing petals and stamens. Moreover, ectopic expression of FaesAP3 rescued stamen development without complementation of petal development in an Arabidopsis ap3 mutant. Our results suggest that FaesAP3 is involved in the development of stamens in buckwheat. These results also suggest that FaesAP3 holds some potential for biotechnical engineering to create a male sterile line of F. esculentum. PMID:25149019

Fang, Zheng-wu; Qi, Rui; Li, Xiao-fang; Liu, Zhi-xiong

2014-10-25

210

ADVANCED PLACEMENT (AP) # AP Course Title Crs Num MSU Course Title Credit  

E-print Network

ADVANCED PLACEMENT (AP) # AP Course Title Crs Num MSU Course Title Credit 13 Art History ARTH 200IA Environmental Sci & Lab BIOE 103CS Environmental Sci & Society 4 43 European History HSTR 101IH Western Art of World Civilization I 3 AND ARTH 201IA Art of World Civilization II 3 14 Art: Studio Art

Dyer, Bill

211

ANL/APS/TB-24 Diamond Monochromators for APS Undulator-A Beamlines  

E-print Network

synthetic diamonds can currently be obtained in the minimum necessary size (typically 4-5 mm on a sideANL/APS/TB-24 Diamond Monochromators for APS Undulator-A Beamlines R.C. Blasdell, L. A. Assoufid .................................................................................1 2. PHYSICAL PROPERTIES OF DIAMONDS ..................................................5 2

Kemner, Ken

212

Tank 241-AP-107, grab samples 7AP-97-1, 7AP-97-2 and 7AP-97-3 analytical results for the final report  

SciTech Connect

This document is the final report for tank 241-AP-107 grab samples. Three grab samples were collected from riser 1 on September 11, 1997. Analyses were performed on samples 7AP-97-1, 7AP-97-2 and 7AP-97-3 in accordance with the Compatibility Grab Sampling and Analysis Plan (TSAP) (Sasaki, 1997) and the Data Quality Objectives for Tank Farms Waste Compatibility Program (DQO) (Rev. 1: Fowler, 1995; Rev. 2: Mulkey and Nuier, 1997). The analytical results are presented in the data summary report (Table 1). A notification was made to East Tank Farms Operations concerning low hydroxide in the tank and a hydroxide (caustic) demand analysis was requested. The request for sample analysis (RSA) (Attachment 2) received for AP-107 indicated that the samples were polychlorinated biphenyl (PCB) suspects. Therefore, prior to performing the requested analyses, aliquots were made to perform PCB analysis in accordance with the 222-S Laboratory administrative procedure, LAP-101-100. The results of this analysis indicated that no PCBs were present at 50 ppm and analysis proceeded as non-PCB samples. The results and raw data for the PCB analysis will be included in a revision to this document. The sample breakdown diagrams (Attachment 1) are provided as a cross-reference for relating the tank farm customer identification numbers with the 222-S Laboratory sample numbers and the portion of sample analyzed.

Steen, F.H.

1997-12-22

213

Automated Plasma Spray (APS) process feasibility study  

NASA Technical Reports Server (NTRS)

An automated plasma spray (APS) process was developed to apply two layer (NiCrAlY and ZrO2-12Y2O3) thermal barrier coatings to aircraft and stationary gas turbine engine blade airfoils. The APS process hardware consists of four subsystems: a mechanical positioning subsystem incorporating two interlaced six degree of freedom assemblies (one for coating deposition and one for coating thickness monitoring); a noncoherent optical metrology subsystem (for in process gaging of the coating thickness buildup at specified points on the specimen); a microprocessor based adaptive system controller (to achieve the desired overall thickness profile on the specimen); and commerical plasma spray equipment. Over fifty JT9D first stage aircraft turbine blade specimens, ten W501B utility turbine blade specimens and dozens of cylindrical specimens were coated with the APS process in preliminary checkout and evaluation studies. The best of the preliminary turbine blade specimens achieved an overall coating thickness uniformity of 53 micrometers (2.1 mils), much better than is achievable manually. Comparative evaluations of coating thickness uniformity for manually sprayed and APS coated specimens were performed. One of the preliminary turbine blade evaluation specimens was subjected to a torch test and metallographic evaluation. Some cylindrical specimens coated with the APS process survived up to 2000 cycles in subsequent burner rig testing.

Fetheroff, C. W.; Derkacs, T.; Matay, I. M.

1981-01-01

214

Simplified SBLOCA Analysis of AP1000  

SciTech Connect

The AP1000 is a 1000 MWe advanced nuclear power plant design that uses passive safety features such as a multi-stage, automatic depressurization system (ADS) and gravity-driven, safety injection from core make-up tanks (CMTs) and an in-containment refueling water storage tank (IRWST) to mitigate SBLOCA events. The period of most safety significance for AP1000 during a SBLOCA event is typically associated with the actuation of the fourth stage of the ADS and subsequent transition from CMT to IRWST safety injection. As this period of a SBLOCA is generally of a quasi-steady nature, the integral performance of the AP1000 can be understood and evaluated with a simplified model of the reactor vessel, ADS, and safety injection from the CMTs and IRWST. The simplified model of the AP1000 consists of a series of steady state simulations that uses drift flux in the core region and homogeneous treatment of the core exit region including the ADS flow paths to generate a family of core flow demand curves as a function of system pressure (i.e. mass flow required to satisfy core cooling). These core flow demand curves are plotted against passive safety system supply curves from the CMTs and IRWST to demonstrate the adequacy of the integral performance of the AP1000 during the most important phase of a SBLOCA. (author)

Brown, William L. [Westinghouse Electric Company LLC, Pittsburgh, PA 15230 (United States)

2004-07-01

215

M ap Info ... SQL Server " , ,,oe , , ,  

E-print Network

M ap Info ¿...°·¨º SQL Server °¿" » , ,,oe , , ´ , ´· (~'·§ G IS º£,--^--¿¸ø , ~' 210093^ Delphi °`¸ M ap Info ¿...° SQL Server °¿~¨«,,--··¢¡£ ,,...·° : G IS; ¿...° ; ,,--°¿ ; ¨«,,··¢ ;M ap Info; SQL Server --...·"¯ : P208¡¡¡¡ ~­OE°¶´º : A ¡¡¡¡ ~´­"¯ : 1000- 3177(2001) 61- 0026- 0030 1¡¡¡¡ --¯¢ (G

Li, Xiang

216

Biodegradation and drug release of chitosan gel beads in subcutaneous air pouches of mice.  

PubMed

Chitosan (CS) gel beads were prepared in 10% amino acid solution (pH 9) and implanted into air pouches (AP) prepared subcutaneously on the dorsal surface of mice. No inflammatory response was observed, and degradation of the beads in the AP increased as their degree of deacetylation decreased. Degradation could be altered by changing the nature of the CS or by increasing the CS concentration. The release of prednisolone (PS) in vivo from CS gel beads was similar to the release in vitro. When a suspension of PS was injected into the AP, the PS had almost completely disappeared 24 h after injection. Retention of PS in the AP was not increased by using a viscous CS solution. Alginate (Alg) gel beads, which were not degraded, released PS slowly into the AP over 3d. The in vitro release profile of PS using 1% CS (deacetylation: 70% (7B) and 80% (8B)) and 1.5% CS (deacetylation: 90% (9B)) gel beads was similar to that with Alg gel beads. However, the in vivo release of PS was affected by the degradability of the gel beads. CS7B and 8B (1%) gel beads had released PS into the AP earlier than 3 d according to their rate of degradation. CS9B (1.5%) gel beads were not degraded after 3 d and went on to release PS into the AP for 3 d similar to the release profile of Alg gel beads. CS9B (2%) gel beads were also not degraded after 3 d and the release of PS from these beads into the AP was sustained; 76% and 27% of administered PS remained in the gel beads after 1 and 3 d, respectively. Therefore, degradation and drug release of CS gel beads can be controlled by changing the structure of the gel matrix, which appears to make these beads a promising biodegradable vehicle for sustained drug delivery. PMID:11217095

Kofuji, K; Ito, T; Murata, Y; Kawashima, S

2001-02-01

217

The Clathrin Adaptor AP-1A Mediates Basolateral Polarity  

PubMed Central

Summary Clathrin and the epithelial-specific clathrin adaptor AP-1B mediate basolateral trafficking in epithelia. However, several epithelia lack AP-1B and mice knocked-out for AP-1B are viable, suggesting the existence of additional mechanisms that control basolateral polarity. Here, we demonstrate a distinct role of the ubiquitous clathrin adaptor AP-1A in basolateral protein sorting. Knock-down of AP-1A causes missorting of basolateral proteins in MDCK cells but only after knock-down of AP-1B, suggesting that AP-1B can compensate for lack of AP-1A. AP-1A localizes predominantly to the TGN and its knock-down promotes spillover of basolateral proteins into common recycling endosomes, the site of function of AP-1B, suggesting complementary roles of both adaptors in basolateral sorting. Yeast two-hybrid assays detect interactions between the basolateral signal of TfR and the medium subunits of both AP-1A and AP-1B. The basolateral sorting function of AP-1A reported here establishes AP-1 as a major regulator of epithelial polarity. PMID:22516199

Gravotta, Diego; Carvajal-Gonzalez, Jose Maria; Mattera, Rafael; Deborde, Sylvie; Banfelder, Jason R.; Bonifacino, Juan S.; Rodriguez-Boulan, Enrique

2013-01-01

218

Public Support for the Press.  

ERIC Educational Resources Information Center

Reports findings of surveys of people's evaluations of press behavior during the Watergate period; concludes that the most important determinants of press criticism were in support of Nixon, party affiliation, and ideology. (GW)

Becker, Lee B.; And Others

1978-01-01

219

Press Relations of Terrorist Organizations.  

ERIC Educational Resources Information Center

Explores and illustrates the different types of press relations commonly undertaken by terrorist organizations. Argues that large and small groups both engage in publicity efforts, but employ different patterns of press relations activities. (SR)

Picard, Robert G.

1989-01-01

220

Alternative Press Center  

NSDL National Science Digital Library

The Alternative Press Center (APC), a non-profit collective, is devoted to "providing access to and increasing public awareness of the alternative press." The APC publishes the Alternative Press Index (API), a comprehensive quarterly subject index to more than 260 alternative periodicals in the social sciences and the humanities. The APC Website provides organizational information as well as information about the content and function of the API. The site also includes an online directory of periodicals in the API, listing subscription information, email addresses, and URLs. In addition, the APC compiles annotated links in a section entitled Alternative Viewpoints on the Internet. The compilation, comprised of over 330 sites, may be browsed by name or subject.

221

Depolarization-induced suppression of spontaneous release in the avian midbrain  

PubMed Central

Spontaneous neurotransmitter release has been considered synaptic noise for decades. Recent work, however, suggests that synaptic events arising from action-potential (AP) independent neurotransmitter release contribute to synaptic function in a manner qualitatively different from AP-dependent release. We investigated the effect of somatic depolarization on spontaneous neurotransmitter release in neurons of the external portion of the chicken inferior colliculus (EX). We found this manipulation affects spontaneous but not AP-dependent release onto EX neurons in a retrograde manner. This depolarization-induced suppression of spontaneous release requires activation of N-methyl-D-aspartate receptors on the presynaptic cell and postsynaptic calcium-dependent vesicle fusion. These results show a novel form of plasticity that allows the postsynaptic cell to selectively modulate spontaneous neurotransmitter release of its afferent inputs. PMID:21389216

Penzo, Mario Alexander; Pena, Jos Luis

2011-01-01

222

APS Presents Awards at 2007 ABRCMS Conference  

NSDL National Science Digital Library

The APS presented awards to six minority undergraduate researchers for their oral and poster presentations in the physiological sciences at the Annual Biomedical Research Conference for Minority Students (ABRCMS) at the Austin Convention Center in Austin, TX from November 7-10, 2007. ABRCMS is a national conference designed to facilitate increased minority involvement in biomedical and behavioral science careers.

APS Education Office (American Physiological Society Education Office)

2008-02-01

223

Why are magnetic AP stars slowly rotating?  

NASA Astrophysics Data System (ADS)

Observational data on rotation of Ap stars suggest that the bulk of their rotation rates orm a separate Maxwellian distribution with an average value 3-4 times lower than the normal star distribution. No evidences for a significant angular momentum (AM) loss on the main sequence (MS) have been found. It is thus concluded that Ap stars must lose a large fraction of their initial angular momentum (AM) in the pre-MS phase of evolution, most probably as a result of the interaction of their primordial magnetic fields with accretion disks and stellar winds. The observationally most acceptable values of accretion rate from the disk, 10^(-8) M_(Sun)/year, of mass loss rate via a magnetized wind, 10^(-8) M_(Sun)/year, and of the surface magnetic field, 1 kG on the ZAMS, result in the AM loss in full agreement with observations. There exists a separate group of extremely slowly rotating Ap stars, with periods of the order of 10-100 years. They are too numerous to come from the distribution describing the bulk of Ap stars. It is conjectured that their extremely low rotation rates are the result of additional AM loss on the MS.

Stepien, K.

1998-04-01

224

Yasir Suhail KvAP channel  

E-print Network

till 100oC, easy to crystallize · Crystal structure worked out by x-ray #12;3 KvAP · Monoclonal during depolarization (channel open) to expose the epitope · The Plan ... ­ Introduce cysteine at a specific site ­ Biotynilate the cysteine residue ­ Use avidin binding to biotinylated cysteine to probe

Yue, David

225

APS Forum on Education Summer 2006 Newsletter  

NSDL National Science Digital Library

The APS Forum on Education (FEd) Summer 2006 Newsletter's Teacher Preparation Section articles included:The Learning Assistant Model for Teacher Education in Science and Technology by Valerie Otero,Undergraduate Learning Assistants at the University of Arkansas by Gay Stewart, andCreating and Sustaining a Teaching and Learning Professional Community at Seattle Pacific University by Lane Seeley and Stamatis Vokos.

2007-09-07

226

APS Presents Awards at 2006 ABRCMS Conference  

NSDL National Science Digital Library

An article from The Physiologist. The APS presented awards to minority undergraduate researchers and was a major conference sponsor at the Annual Biomedical Research Conference for Minority Students (ABRCMS) at the Anaheim Convention Center and Anaheim Marriott hotel in Anaheim, CA from November 8-11, 2006.

APS Education Office (American Physiological Society Education Office)

2007-04-01

227

AP Biology Investigation #6: Cellular Respiration  

NSDL National Science Digital Library

This is the Advanced Placement Investigation into cellular respiration (#6). The investigation was developed by the College Board for use in AP Biology classes. Students begin by investigating the question, What factors affect the rate of cellular respiration in multicellular organisms? Later, students investigate one of their own questions that arose during the first investigation. Wisconsin Fast Plants are used as a model organism.

Approach, Ap B.

228

The AP Descriptive Chemistry Question: Student Errors  

ERIC Educational Resources Information Center

For over a decade, the authors have been involved in a design theory experiment providing software for high school students preparing for the descriptive question on the Advanced Placement (AP) chemistry examination. Since 1997, the software has been available as a Web site offering repeatable practice. This study describes a 4-year project during

Crippen, Kent; Brooks, David W.

2005-01-01

229

Two Successful Approaches to Teaching AP Government  

ERIC Educational Resources Information Center

Amador Valley High School, in Pleasanton, California, uses two unique approaches to teaching Advanced Placement Government and Politics. AP Government consists of six units: Constitutional Underpinnings; Political Behavior and Political Beliefs; Mass Media, Interest Groups, and Political Parties; Institutions of Government; Civil Liberties and

Ladd, Brian; Stepp, Heidi

2013-01-01

230

Functional description of APS beamline front ends  

SciTech Connect

Traditional synchrotron sources were designed to produce bending magnet radiation and have proven to be an essential scientific tool. Currently, a new generation of synchrotron sources is being built that will be able to accommodate a large number of insertion device (ID) and high quality bending magnet (BM) sources. One example is the 7-GeV Advanced Photon Source (APS) now under construction at Argonne National Laboratory. The research and development effort at the APS is designed to fully develop the potential of this new generation of synchrotron sources. Of the 40 straight sections in the APS storage ring, 34 will be available for IDs. The remaining six sections are reserved for the storage ring hardware and diagnostics. Although the ring incorporates 80 BMs, only 40 of them can be used to extract radiation. The accelerator hardware shadows five of these 40 bending magnets, so the maximum number of BM sources on the lattice is 35. Generally, a photon beamline consists of four functional sections. The first section is the ID or the BM, which provides the radiation source. The second section, which is immediately outside the storage ring but inside a concrete shielding tunnel, is the front end, which is designed to control, define, and/or confine the x-ray beam. In the case of the APS, the front ends are designed to confine the photon beam. The third section, just outside the concrete shielding tunnel and on the experimental floor, is the first optics enclosure, which contains optics to filter and monochromatize the photon beam. The fourth section of a beamline consists of beam transports, additional optics, and experiment stations to do the scientific investigations. This document describes only the front ends of the APS beamlines.

Kuzay, T.

1993-02-01

231

Whoopers Released  

USGS Multimedia Gallery

A Whooping crane chick is released into a temporary pen to acclimate before being released into the wild. Four of the endangered chicks, hatched and raised by their parents at the U.S. Geological Surveys Patuxent Wildlife Research Center in Laurel, Maryland, were released on Necedah Nat...

232

Press Briefings Exercise.  

ERIC Educational Resources Information Center

Describes a college-level political science assignment where students access the full text of a White House or federal agency briefing; evaluate its content; and comment on the interpretation of the information in the national press. Includes a step-by-step guide to gathering and analyzing the information. (MJP)

Frantzich, Stephen

1995-01-01

233

YB-1 represses AP1-dependent gene transactivation and interacts with an AP-1 DNA sequence  

PubMed Central

Involvement of the AP-1 (activator protein-1) transcription factor has been demonstrated previously in the regulation of cell proliferation and cell-cycle progression, in the control of cell migration, invasion and metastasis, and in signal transduction, stress responsiveness, DNA replication and DNA repair. YB-1 (Y-box-binding protein-1) has also been implicated in many of these processes. However, the mechanism by which YB-1 mediates these processes is poorly understood. In the present study, we report that overexpression of a transfected gene encoding YB-1 in human HeLa cervical carcinoma cells significantly represses the transactivation of a minimal AP-1 reporter construct in response to the tumour promoter PMA. YB-1 also represses mRNA expression and PMA-induced promoter transactivation of the endogenous AP-1 target gene encoding matrix metalloproteinase-12 (metalloelastase). YB-1 transrepression of both the minimal and matrix metalloproteinase-12 promoter reporter constructs is dependent on the AP-1 sequence. To identify new nuclear proteins that bind specifically to the AP-1 DNA-binding site, we devised a DNA-affinity-chromatography-based assay termed NAPSTER (nucleotide-affinity preincubation specificity test of recognition) and discovered a 49kDa protein from human cancer cells that binds in a sequence-specific manner to the AP-1 DNA sequence. By tandem MS fragmentation sequencing analyses we determined that p49 is a YB-1. Immunoblotting of the NAPSTER-purified p49 protein using anti-YB-1 antibodies confirmed YB-1 binding to the AP-1 DNA sequence, as did gel mobility-supershift assays using YB-1 antibodies. This is the first report of YB-1 transrepression and interaction at the AP-1 DNA-binding site. PMID:15702969

2005-01-01

234

APS/NIDDK Minority Travel Fellows Attend the 2012 APS Conferences  

NSDL National Science Digital Library

This article is on page 238 of The Physiologist, December 2012. The APS regularly awards Travel Fellowships for underrepresented minority students to attend the APS scientific meetings with funds provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). In the final year of support, these Fellowships provided up to $1,800 in expense reimbursement for meeting registration, transportation, meals, and lodging.

APS Education Office (American Physiological Society Education Office)

2012-12-01

235

AP-42 ADDITIONS AND REVISIONS - RESIDENTIAL WOOD COMBUSTION  

EPA Science Inventory

This project develops emission factors, etc., for residential fireplaces and woodstoves which are incorporated into AP-42. AP42 is a massive collection of material which describes processes which generate air emissions and presents emission factors and control effectiveness infor...

236

Book Eyes Impact of AP Classes and Exams  

ERIC Educational Resources Information Center

At a time of mushrooming interest in Advanced Placement (AP) tests, a new book, "AP: A Critical Examination of the Advanced Placement Program," assembles studies on how capable the program is of meeting the increasingly diverse expectations held up for it. Growing out of a symposium held at Harvard in 2007, the book focuses on AP science courses

Viadero, Debra

2010-01-01

237

APS-3.1.2.1.0 ARGONNE NATIONAL LABORATORY  

E-print Network

Office of Science #12;#12;APS Safety Assessment Document Change Record June 2012 iii The APS Final SafetyAPS-3.1.2.1.0 Rev. 4 ARGONNE NATIONAL LABORATORY 9700 South Cass Avenue, Lemont, Illinois 60439 ADVANCED PHOTON SOURCE SAFETY ASSESSMENT DOCUMENT June 2012 work sponsored by U.S. DEPARTMENT OF ENERGY

Kemner, Ken

238

Chrysoeriol potently inhibits the induction of nitric oxide synthase by blocking AP-1 activation.  

PubMed

Chrysoeriol is a flavonoid with antioxidant and anti-inflammatory activities. Despite the large number of studies performed on its biological activities, no clear picture of its mode of action has emerged. In the present study, we isolated chrysoeriol from the leaves of Digitalis purpurea (foxglove), and studied its effect on the induction of the inducible nitric oxide synthase (iNOS) gene, and the mechanism of this induction in Raw264.7 macrophages. Chrysoeriol pretreatment potently inhibited the release of NO in the cells treated with lipopolysaccharide (LPS), and Western blot and RT-PCR analyses revealed that chrysoeriol inhibited the LPS-induced inductions of iNOS gene. Moreover, it is known that the activations of nuclear factor-kappaB (NF-kappaB) and activator protein 1 (AP-1) are crucial steps in the transcriptional activation of the iNOS gene. Here, we found that chrysoeriol selectively suppressed AP-1 activation, and that activation of AP-1 is likely to be essential for iNOS induction in LPS-treated macrophages. This presumed inhibitory effect on AP-1 activation by chrysoeriol may be associated with its potent NO blocking and anti-inflammatory effects. PMID:16228289

Choi, Doo-Youn; Lee, Jeong Yong; Kim, Mi-Ran; Woo, Eun-Rhan; Kim, Yoon Gyoon; Kang, Keon Wook

2005-12-01

239

Life Sciences, Vol. 44, pp. 265-271 Pergamon Press Printed in the U.S.A.  

E-print Network

. However, these doses produce elevations in plasma and brain fenfluramine concentrations (12, 13) which fax.00 + ,00 Copyright (c) 1989 Pergamon Press plc #12;266 Chronic D-Fenfluramine and 5-HT Release Vol. 44~ No

Schaechter, Judith D.

240

APS Museum "Dialogues with Darwin" Online Exhibition  

NSDL National Science Digital Library

The American Philosophical Society (APS) Museum's "Dialogues with Darwin" exhibition tells the story of Charles Darwins theory of evolution and considers the debates about evolution that came both before and after him. The online gallery features all objects, label texts, and wall texts on view in the actual exhibition. The site includes a link to an Educator's Guide which can be downloaded as a pdf file.

American Philosophical Society & Philadelphia Area Center for History of Science

241

Final report for tank 241-AP-108, grab samples 8AP-96-1, 8AP-96-2 and 8AP-96-FB  

SciTech Connect

This document is the final report deliverable for the tank 241-AP-108 grab samples. The samples were subsampled and analyzed in accordance with the TSAP. Included in this report are the results for the Waste Compatibility analyses, with the exception of DSC and thermogravimetric analysis (TGA) results which were presented in the 45 Day report (Part 2 of this document). The raw data for all analyses, with the exception of DSC and TGA, are also included in this report.

Esch, R.A.

1996-04-19

242

Cultural Diversity in AP Art History  

ERIC Educational Resources Information Center

Teaching AP Art History is like running on a treadmill that is moving faster than a teacher can run. Many teachers are out of breath before the end of the term and wonder how in the world they can cover every chapter. Because time is short and art from pre-history through to the present, including the non-European traditions, must be covered, this

Bolte, Frances R.

2006-01-01

243

APS storage ring vacuum system performance  

SciTech Connect

The Advanced Photon Source (APS) storage ring was designed to operated with 7-GeV, 100-mA positron beam with lifetimes > 20 hours. The lifetime is limited by residual gas scattering and Touschek scattering at this time. Photon-stimulated desorption and microwave power in the rf cavities are the main gas loads. Comparison of actual system gas loads and design calculations will be given. In addition, several special features of the storage ring vacuum system will be presented.

Noonan, J.R.; Gagliano, J.; Goeppner, G.A. [and others

1997-06-01

244

Release reaction of brain-derived neurotrophic factor (BDNF) through PAR1 activation and its two distinct pools in human platelets.  

PubMed

Brain-derived neurotrophic factor (BDNF) is a cytokine that plays important roles in the survival, development, and plasticity of neurons. BDNF is also expressed in peripheral tissues and cells. In this article, we report the BDNF release reaction through thrombin stimulation and its localization in human platelets. Platelets from healthy volunteers were subjected to PAR1-AP or PAR4-AP stimulation. Release of BDNF was measured by ELISA. Localization of BDNF in resting and thrombin-activated platelets was examined by immunoelectron microscopy and sucrose gradient ultracentrifugation following western blotting. BDNF was released dose-dependently with PAR1-AP concentrations with drastic release at low PAR1-AP concentrations and gently release at high PAR1-AP concentrations. Maximum BDNF release was approximately 37% at 132 ?M PAR1-AP. In contrast, 3.8% BDNF was released with 1.13 mM PAR4-AP stimulation. In immunoelectron microscopy and sucrose gradient ultracentrifugation analyses, BDNF was detected not only in ?-granules but also cytoplasm in of the resting platelets, and it was distributed in the swollen open canalicular system fused to ?-granules at 1 min and disappeared at 5 min after stimulation by thrombin. However, BDNF in cytoplasm remained throughout platelet activation. In conclusions, we demonstrate that BDNF is released from platelets through predominately PAR1 regulation. Furthermore, we identified two pools of BDNF in the ?-granules and cytoplasm of human platelets, and only BDNF in ?-granules is released through platelet activation. PMID:21924459

Tamura, Shogo; Suzuki, Hidenori; Hirowatari, Yuji; Hatase, Masanao; Nagasawa, Ayumi; Matsuno, Kazuhiko; Kobayashi, Seiichi; Moriyama, Takanori

2011-11-01

245

Student Press Law Center  

NSDL National Science Digital Library

Created in 1974, the Student Press Law Center (SPLC) is the ânation's only legal assistance agency devoted exclusively to educating high school and college journalists about the rights and responsibilities embodied in the First Amendment.â Based in Arlington, Virginia the Center provides free legal advice and information along with low-cost educational materials. On its homepage, visitors can make their way through sections that include Know Your Rights and Classroom Resources. In Know Your Rights, visitors can learn about the rights of high school journalists and educators, peruse an online law library, and check out an interactive map tracking the latest legal developments in student press rights nationally. Moving on, the Classroom Resources area brings together dozens of classroom handouts, presentations, and some fun short quizzes regarding libel, privacy, and other media-law issues.

246

Ectopic expression of AP-2? transcription factor suppresses glioma progression  

PubMed Central

The transcriptional factor AP-2? is a tumor suppressor gene and is downregulated in various neoplasms including glioma. Although the level of AP-2? is negatively associated with the grade of human glioma, the specific functions of AP-2? in glioma are still unknown. In this study, we experimentally showed that artificial overexpression of AP-2? in glioma T98G and U251 cells significantly downregulated the mRNA levels of Bcl-xl, Bcl-2, c-IAP2 and survivin, together with upregulation of the Hrk mRNA levels. Reintroduction of AP-2? also induced downregulation of the protein levels of survivin and VEGF in glioma cells. In biological assays with T98G and U251 cells, AP-2? reduced tumor cell growth, increased cell death, attenuated cell migration and endothelial tube formation. The AP-2? transcription factor may play an important role in suppressing glioma progression.

Su, Wenjing; Xia, Juan; Chen, Xueqin; Xu, Miao; Nie, Ling; Chen, Ni; Gong, Jing; Li, Xinglan; Zhou, Qiao

2014-01-01

247

Vinpocetine inhibits glutamate release induced by the convulsive agent 4-aminopyridine more potently than several antiepileptic drugs.  

PubMed

4-Aminopyridine (4-AP) is a convulsing agent that in vivo preferentially releases Glu, the most important excitatory amino acid neurotransmitter in the brain. Here the ionic dependence of 4-AP-induced Glu release and the effects of several of the most common antiepileptic drugs (AEDs) and of the new potential AED, vinpocetine on 4-AP-induced Glu release were characterized in hippocampus isolated nerve endings pre-loaded with labelled Glu ([3H]Glu). 4-AP-induced [3H]Glu release was composed by a tetrodotoxin (TTX) sensitive and external Ca2+ dependent fraction and a TTX insensitive fraction that was sensitive to the excitatory amino acid transporter inhibitor, TBOA. The AEDs: carbamazepine, phenytoin, lamotrigine and oxcarbazepine at the highest dose tested only reduced [3H]Glu release to 4-AP between 50-60%, and topiramate was ineffective. Vinpocetine at a much lower concentration than the above AEDs, abolished [3H]Glu release to 4-AP. We conclude that the decrease in [3H]Glu release linked to the direct blockade of presynaptic Na+ channels, may importantly contribute to the anticonvulsant actions of all the drugs tested here (except topiramate); and that the significantly greater vinpocetine effect in magnitude and potency on [3H]Glu release when excitability is exacerbated like during seizures, may involve the increase additionally exerted by vinpocetine in some K+ channels permeability. PMID:21737246

Sitges, M; Sanchez-Tafolla, B M; Chiu, L M; Aldana, B I; Guarneros, A

2011-10-01

248

&p.1:Abstract The MADS domain proteins AP1, AP3, PI, and AG are required to specify the four classes of organs  

E-print Network

&p.1:Abstract The MADS domain proteins AP1, AP3, PI, and AG are required to specify the four2) (class A); APETALA3 (AP3), PISTILLATA (PI) (class B); and AGAMOUS (AG) (class C). Mutations in these genes result in homeotic transformations of one floral organ into another. Four (AP1, AP3, PI, AG

Krizek, Beth

249

CSU, FULLERTON CREDIT FOR EXTERNAL EXAMS (AP, IB, CLEP) ADVANCED PLACEMENT EXAMS (AP) SCORE UNITS COURSE CREDIT GEN EDUC BEGIN DATE END DATE  

E-print Network

CSU, FULLERTON CREDIT FOR EXTERNAL EXAMS (AP, IB, CLEP) ADVANCED PLACEMENT EXAMS (AP) SCORE UNITS ENGL 101 GE I.B 3 ENGL 105 GE III.B.2 Updated 11/30/10 #12;CSU, FULLERTON CREDIT FOR EXTERNAL EXAMS (AP, IB, CLEP) ADVANCED PLACEMENT EXAMS (AP) SCORE UNITS COURSE CREDIT GEN EDUC BEGIN DATE END DATE AP

de Lijser, Peter

250

Switchable aptamers for biosensing and bioseparation of viruses (SwAps-V).  

PubMed

There is a widespread interest in the development of aptamer-based affinity chromatographic methods for purification of biomolecules. Regardless of the many advantages exhibited by aptamers when compared to other recognition elements, the lack of an efficient regeneration technique that can be generalized to all targets has encumbered further integration of aptamers into affinity-based purification methods. Here we offer switchable aptamers (SwAps) that have been developed to solve this problem and move aptamer-based chromatography forward. SwAps are controlled-affinity aptamers, which have been employed here to purify vesicular stomatitis virus (VSV) as a model case, however this technique can be extended to all biologically significant molecules. VSV is one oncolytic virus out of an arsenal of potential candidates shown to provide selective destruction of cancer cells both in vitro and in vivo. These SwAps were developed in the presence of Ca(2+) and Mg(2+) ions where they cannot bind to their target VSV in absence of these cations. Upon addition of EDTA and EGTA, the divalent cations were sequestered from the stabilized aptameric structure causing a conformational change and subsequently release of the virus. Both flow cytometry and electrochemical impedance spectroscopy were employed to estimate the binding affinities between the selected SwAps and VSV and to determine the coefficient of switching (CoS) upon elution. Among fifteen sequenced SwAps, four have exhibited high affinity to VSV and ability to switch upon elution and thus were further integrated into streptavidin-coated magnetic beads for purification of VSV. PMID:25190090

Wehbe, Mohamed; Labib, Mahmoud; Muharemagic, Darija; Zamay, Anna S; Berezovski, Maxim V

2015-05-15

251

A comparison of impulse drying to double felted pressing on pilot- scale shoe presses and roll presses  

SciTech Connect

Pilot-scale shoe press and roll press experiments have been conducted to compare impulse drying and double felted pressing. Both ceramic coated and Beloit Type C press rolls have been evaluated. The experiments show that impulse drying can provide significantly higher outgoing solids than double felled pressing at the same impulse. For example, at an impulse of 0.234 MPa seconds (34 psi seconds), sheets at an ingoing solids of 52% were impulse dried (using the Beloit Type C press roll) to 68% solids while optimized double felled pressing could only yield press dryness of, at most, 60%.

Orloff, D.I.

1992-08-01

252

Iodine Volatility and pH Control in the AP-600 Reactor  

SciTech Connect

Two design-basis accidents for the AP-600 reactor are formulated and evaluate~ in which significant bypass of the principal pH control system occurs. Some iodine released from the reactor primary system is retained in the Incontainment Refaeling Water Storage Tank (IRWST) water, never entering the containment where trisodium phosphate produces a high pH. Some of this iodine is volatilized and is transported into the reactor containment airspace. in the worst case, a small fraction is released to the environment at design-basis leak rate, yielding a total cumulative iodine release at 30 days of 0.0352 mol (0.023% of core iodine inventory) due to the iodine volatilization bypassing the pH control system. No fission product removal in the containment atmosphere (i.e., natural deposition sprays) is considered.

Beahm, E.C.; Weber, C.F.

1998-10-01

253

Multipassband photometric mapping of three fast rotating stars: HII 1883, AP 86 and AP 226  

NASA Astrophysics Data System (ADS)

The analysis of multipassband photometry was carried out for three rapidly rotating stars: HII 1883, AP 86 and AP 226. Two different approaches were used for starspot mapping. In the first approach the stellar spottedness is approximated by set of circular spots. Spot parameters (coordinates of the spot center, radius and temperature) are searched by fitting of observed light curves. The idea of the second approach is consisted in partition of the stellar surface into small areas. Searching of the temperature distribution is carried out by the fitting of the observed light curves. Stellar atmosphere theory was used for modeling of the theoretical light curves in both techniques.

Kolbin, A. I.; Sakhibullin, N. A.; Gabdeev, M. M.

2015-02-01

254

Kinetic organization of Ca2+ signals that regulate synaptic release efficacy in sympathetic neurons.  

PubMed

Calcium regulation of neurotransmitter release is essential for maintenance of synaptic transmission. However, the temporal and spatial organization of Ca(2+) dynamics that regulate synaptic vesicle (SV) release efficacy in sympathetic neurons is poorly understood. Here, we investigate the N-type Ca(2+) channel-mediated kinetic structure of Ca(2+) regulation of cholinergic transmission of sympathetic neurons. We measured the effect of Ca(2+) chelation with fast 1,2-bis(2-aminophenoxy) ethane-tetraacetic acid (BAPTA) and slow ethyleneglycol-tetraacetic acid (EGTA) buffers on exocytosis, synaptic depression, and recovery of the readily releasable vesicle pool (RRP), after both single action potential (AP) and repetitive APs. Surprisingly, postsynaptic potentials peaking at ~12 milliseconds after the AP was inhibited by both rapid and slow Ca(2+) buffers suggests that, in addition to the well known fast Ca(2+) signals at the active zone (AZ), slow Ca(2+) signals at the peak of Ca(2+) entry also contribute to paired-pulse or repetitive AP responses. Following a single AP, discrete Ca(2+) transient increase regulated synaptic depression in rapid (<30-millisecond) and slow (<120-millisecond) phases. In contrast, following prolonged AP trains, synaptic depression was reduced by a slow Ca(2+) signal regulation lasting >200 milliseconds. Finally, after an AP burst, recovery of the RRP was mediated by an AP-dependent rapid Ca(2+) signal, and the expansion of releasable SV number by an AP firing activity-dependent slow Ca(2+) signal. These data indicate that local Ca(2+) signals operating near Ca(2+) sources in the AZ are organized into discrete fast and slow temporal phases that remodel exocytosis and short-term plasticity to ensure long-term stability in acetylcholine release efficacy. PMID:24981043

Mori, Michinori; Tanifuji, Shota; Mochida, Sumiko

2014-09-01

255

Measure Your Sew - How: Pressing Points.  

E-print Network

8-1267 OC U A245.7, 73 , 1.1267 Measure Your Sew-How Pressing Points Texas Agricultural Extension Service . The Texas A&M University System . Daniel C. Pfannstiel, Director, College Station, Texas PRESSING POINTS Marlene Odle-Kemp* Pressing... Equipment Whether tailoring, sewing or just mending, pressing is an important part of clothing construction. Pressing provides shaping, neat edges and finishing touches for a professional look. Carefully pressing during garment construction results in a...

Odle-Kemp, Marlene

1979-01-01

256

PRESS SHOP. SEVEN BLISS PRESSES STAMP OUT A VARIETY OF ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

PRESS SHOP. SEVEN BLISS PRESSES STAMP OUT A VARIETY OF CARTRIDGE AND SHELL CASINGS. THIS DEPARTMENT WAS TRANSFORMED FROM A MONEY-LOSING OPERATION TO A PROFIT CENTER UNDER THE FIRST WORKER-MANAGED QUALITY CIRCLE IN THE PLANT. - American Brass Foundry, 70 Sayre Street, Buffalo, Erie County, NY

257

CIDER PRESS, LOOKING SOUTHEAST ACROSS THE SCHUYLKILL RIVER. THIS PRESS, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

CIDER PRESS, LOOKING SOUTHEAST ACROSS THE SCHUYLKILL RIVER. THIS PRESS, CARVED OUT OF A LARGE BOULDER AT THE RIVERS EDGE, PROBABLY DATES FROM THE LIFETIME OF JOHN BARTRAM, IF NOT TO THE SWEDISH SETTLERS BEFORE HIM. THE IRON FENCE IS A NINETEENTH-CENTURY ADDITION - John Bartram House & Garden, 54th Street & Lindbergh Boulevard, Philadelphia, Philadelphia County, PA

258

Electromagnetic field analysis of septum magnet for APS positron accumulator ring  

SciTech Connect

This report consists of three parts. The first part describes a numerical analysis method for the electromagnetic field analysis of a septum magnet. A novel improvement to the treatment of exciting currents in the time-domain is proposed. The second part discusses numerical predictions of the electromagnetic characteristics of the APS PAR septum. The time variations of stray field and eddy currents are shown for three magnet designs. The last part explores how decreasing the septum material conductivity affects the stray field. The decrease of conductivity may be caused by an inadequate manufacturing of the septum material. The significance of a high quality septum, or flat interface between copper and iron, is emphasized from a point of view of stray field. An ideal method for joining two different metals without distortion, called HIP (Hot Isostatic Pressing), is introduced and recommended based on the authors` experience.

Yokoi, Toshiaki; Turner, L.R.

1995-07-01

259

Review of the APS SR RF systems.  

SciTech Connect

The Advanced Photon Source (APS) is a 7-GeV full energy storage ring (SR) for generating synchrotron radiation with an injector. The storage ring cavities consist of four groups of four single cells powered by up to four 1-MW klystrons for up to 300-mA operation. A review of the operation of the rf system as well as rf-related beam dynamics is presented. This review includes rf power distribution, low-level feedback, control law, beam loading, beam instabilities, higher-order modes, and beam-induced multipactoring.

Song, J.J.; Cours, A.; Grelick, A.; Harkay, K.; Horan, D.; Kang, Y.W.; Kustom, R.L.; Nassiri, A.; Pile, G.; Smith, T.L.

1998-03-31

260

Word Press Editorial Calendar  

NSDL National Science Digital Library

If you're a blogger, you probably make plans both grand and modest about publishing new posts and content. One can be easily overwhelmed by such plans, and it's nice to have a way to keep up to date with such important matters. For those using WordPress, the Editorial Calendar plugin allows users to view all of their posts, their status, and information about how many posts are planned for a given day or week. It's quite easy to use and it is compatible with all operating systems.

261

ARTICLE IN PRESS Physica A ( )  

E-print Network

as the smoothing Corresponding author. E-mail address: lovejoy@physics.mcgill.ca (S. Lovejoy). 0378-4371/$ ­ see this article in press as: S. Lovejoy, et al., Scattering in thick multifractal clouds, Part II: Multiple scattering, Physica A (2009), doi:10.1016/j.physa.2009.05.037 #12;ARTICLE IN PRESS 2 S. Lovejoy et al. / P

Lovejoy, Shaun

262

ARTICLE IN PRESS Physica A ( )  

E-print Network

ARTICLE IN PRESS Physica A ( ) ­ Contents lists available at ScienceDirect Physica A journal either solves or at least decouples the spatial degrees of freedom so that the original problem becomes reserved. doi:10.1016/j.physa.2010.03.017 Please cite this article in press as: S. ?stlund, A one

?stlund, Stellan

263

Kingston University Press Limited (KUP)  

E-print Network

Kingston University Press Limited (KUP) Freedom of Information Act 2000 Publication Scheme December 2008 #12;Freedom of Information Act 2000 The Freedom of Information Act 2000 (the Act) gives a right, with some exemptions, for access to all types of recorded information held by Kingston University Press

Matthews, Adrian

264

In vitro dissolution and in vivo gamma scintigraphic evaluation of press-coated salbutamol sulfate tablets.  

PubMed

The aim of this study was to investigate the in vitro and in vivo performance of salbutamol sulfate press-coated tablets for delayed release. The in vitro release behavior of press-coated tablets with the outer layer of PEG 6000/ Eudragit S100 blends (2:1) in pH 1.2 (0.1 mol L-1 HCl) and then pH 6.8 buffer solution was examined. Morphological change of the press-coated tablet during in vitro release was recorded with a digital camera. Release of salbutamol sulfate from press-coated tablets was less than 5 % before 3 h and was completed after 8 h in pH 6.8 phosphate buffer solution. In vivo gamma scintigraphy study carried out on healthy men indicated that the designed system released the drug in lower parts of the GI tract after a lag time of 5 hours. The results showed the capability of the system of achieving delayed release of the drug in both in vitro and in vivo gamma scintigraphy studies. PMID:24451078

Li, Wei; Shi, Cai-Hong; Sheng, Yi-Ling; Cui, Ping; Zhao, Yu-Qing; Zhang, Xiang-Rong

2013-12-01

265

Biological Control of Bemisia argentifolii (Homoptera: Aleyrodidae) on Poinsettia with Inundative Releases of Encarsia formosa (Hymenoptera  

E-print Network

Biological Control of Bemisia argentifolii (Homoptera: Aleyrodidae) on Poinsettia with Inundative releases of the para- sitoid Encarsia formosa for control of Bemisia argenti- folii on poinsettia observed levels of mortal- ity and parasitism. 1997 Academic Press KEY WORDS: Bemisia argentifolii

Hoddle, Mark S.

266

Iran Weekly Press Digest  

NSDL National Science Digital Library

The Iran Weekly Press Digest, a weekly review of the Iranian press in English, contains a number of articles on the summit of the Organisation of the Islamic Conference and its significance for Iran in its archived and current issues. The eighth summit of the Organisation of the Islamic Conference was recently held in Tehran, Iran. Iran recently hosted representatives from 55 countries to a three-day Muslim summit in Tehran in a move which is being seen as a new phase in the country's re-emergence after years of relative isolation. The acceptance of Iran's invitations by senior figures from former enemies such as Saudi Arabia and Iraq has been portrayed by Iranian leaders and many others as a strong setback for US attempts to politically quarantine that country. Representatives considered 142 resolutions prepared by foreign ministers on issues including Middle East peace, regional conflicts, terrorism and human rights. However, perhaps the most significant outcome of the summit has been a reintroduction of Iran into the Muslim community of nations. Capitalizing on current anti-American sentiments and the recent election of a relatively moderate president, Iran hopes to rebuild its relationships with its neighbors and once again become a regional leader, a position it held for approximately 3000 years.

1997-01-01

267

APS Insertion Devices: Recent Developments and Results.  

PubMed

The Advanced Photon Source (APS) now has a total of 23 insertion devices (IDs). Over two-thirds of them are installed on the storage ring. The installed devices include 18, 27 and 55 mm-period undulators; an 85 mm-period wiggler; a 16 cm-period elliptical multipole wiggler; and many 33 mm-period undulators. Most of the IDs occupy storage-ring straight sections equipped with 8 mm vertical-aperture vacuum chambers. All of the IDs were measured magnetically at the APS and, in most cases, underwent a final magnetic tuning in order to minimize variation in the various integrals of the field through the ID over the full gap range. Special shimming techniques to correct magnetic field parameters in appropriate gap-dependent ways were developed and applied. Measurements of the closed-orbit distortion as a function of the ID gap variation have been completed, and results are in a good agreement with magnetic measurements. Spectral diagnostics of the ID radiation, including measurements of the absolute spectral flux, brilliance and polarization, show excellent agreement between calculated and measured results. Studies of the sensitivity of IDs to radiation exposure and measurements of the dose rate received by the IDs are in progress. PMID:15263477

Gluskin, E

1998-05-01

268

The APS control system network upgrade.  

SciTech Connect

When it was installed,the Advanced Photon Source (APS) control system network was at the state-of-the-art. Different aspects of the system have been reported at previous meetings [1,2]. As loads on the controls network have increased due to newer and faster workstations and front-end computers, we have found performance of the system declining and have implemented an upgraded network. There have been dramatic advances in networking hardware in the last several years. The upgraded APS controls network replaces the original FDDI backbone and shared Ethernet hubs with redundant gigabit uplinks and fully switched 10/100 Ethernet switches with backplane fabrics in excess of 20 Gbits/s (Gbps). The central collapsed backbone FDDI concentrator has been replaced with a Gigabit Ethernet switch with greater than 30 Gbps backplane fabric. Full redundancy of the system has been maintained. This paper will discuss this upgrade and include performance data and performance comparisons with the original network.

Sidorowicz, K. v.; Leibfritz, D.; McDowell, W. P.

1999-10-22

269

Development of Emergency Response Guidelines (ERGs) for AP1000  

Microsoft Academic Search

The AP1000 is two-loop 1100 MWe advanced pressurized water reactor (PWR) that uses passive safety features to enhance plant safety and to provide significant and measurable improvements in plant simplification, reliability, investment protection and plant costs. The AP1000 uses proven technology, which builds on over 30 years of operating PWR experience. The AP1000 final design certification has been approved by

Yuichi Hayashi; Gianfranco Saiu; Richard F. Wright

2006-01-01

270

Project W-211, initial tank retrieval systems, description of operations for 241-AP-102 and 241-AP-104  

SciTech Connect

The primary purpose of the Initial Tank Retrieval Systems (ITRS) is to provide systems for retrieval of radioactive wastes stored in underground double-shell tanks (DSTS) for transfer to alternate storage, evaporation, pretreatment or treatment, while concurrently reducing risks associated with safety watch list and other DSTs. This Description of Operations (DOO) defines the control philosophy for the waste retrieval system for tanks 241-AP-102 (AP-102) and 241-AP-104 (AP-104). This DOO will provide a basis for the detailed design of the Retrieval Control System (RCS) for AP-102 and AP-104 and establishes test criteria for the RCS. The test criteria will be used during qualification testing and acceptance testing to verify operability.

RIECK, C.A.

1999-02-25

271

PressRelease|TheFitzwilliamMuseum Trumpington Street  

E-print Network

of modern calligraphy from across the world on show at the Fitzwilliam Museum Calligraphy Today 10 November features works from a new collection of modern calligraphy acquired by the Fitzwilliam in 2008. Organised. These latest pieces create a modern archive for future generations on the art of calligraphy today. The new

Zeki, Semir

272

OFFICE OF COMMUNICATIONS PRESS RELEASE -TUESDAY, AUGUST 11, 2009  

E-print Network

near the boiling point. As the temperature of water increases, fewer and fewer of these clumps exist reaches its maximum density at about 4° Celsius. Above and below this temperature, water is less dense Reveal the Dance of Water Menlo Park, Calif. -- Water is familiar to everyone--it shapes our bodies

Wechsler, Risa H.

273

PressRelease|TheFitzwilliamMuseum 16 March 2010  

E-print Network

range from Ancient Egyptian, Greek and Roman antiquities to the arts of the 21st century and include Bought with a contribution from The Art Fund, 2000 Like Britain, Japan is a series of islands, and the pervasive presence of the sea has shaped Japanese lives and art. This selection of woodcut prints and books

Zeki, Semir

274

PressRelease|TheFitzwilliamMuseum 09 May 2011  

E-print Network

Ancient Egyptian, Greek and Roman antiquities to the arts of the 21st century and include masterpieces, family activities including lantern making workshops, demonstrations of how ancient Greek oil lamps were in with national Museums at Night weekend, opening its doors for an evening of events, art and music on Friday 13

Zeki, Semir

275

PressRelease|TheFitzwilliamMuseum 14 October 2009  

E-print Network

the leading authority on Renaissance medals in the post-War period, Graham Pollard's entire career visiting so often by Museum staff, Pollard rose to work to become Keeper of Coins and Medals before the city's success in its war against Florence in 1479 · A 1519 bronze portrait medal of Renaissance

Zeki, Semir

276

For Immediate Release Office of the Press Secretary  

E-print Network

as President by the Constitution and the laws of the United States of America, and to obtain recommendations's Commission on Implementation of United States Space Exploration Policy By the authority vested in me concerning implementation of the new vision for space exploration activities of the United States

Rathbun, Julie A.

277

PressRelease|TheFitzwilliamMuseum 1 August 2008  

E-print Network

and interpretation of art in museums and galleries all over the world. Presenting a fascinating portrait of Cambridge's indomitable character, his reforming principles and his notorious determination in forcefully pursuing only, cluttered miscellany with limited opening hours to the world-class public art museum it is today. A great

Zeki, Semir

278

National Hurricane Preparedness Week 2012 Page 1 Press Release  

E-print Network

to prepare. In support of this call to prepare, the Federal Emergency Management Agency (FEMA to strengthen your home and business against hurricanes. Download FEMA's mobile app #12;National Hurricane

279

For Immediate Release Office of the Press Secretary  

E-print Network

infrastructure. We have begun an ambitious research program to develop a viable hydrogen powered automobile. We dependent on energy from unstable parts of the world. We will continue improving pipelines and gas terminals

280

For Immediate Release Office of the Press Secretary  

E-print Network

efficiency will help consumers save money. Increasing energy efficiency will leave American businesses for oil is growing faster than global supply. Here in America, we have become too dependent -- too dependent -- on the increasingly limited supply of foreign oil for our own energy needs. For many years

281

PressRelease|TheFitzwilliamMuseum 12 October 2009  

E-print Network

going on display for the first time. Recent Acquisitions of Drawings and Prints (opens 20 October an elegant study of arms and hands attributed to Polidoro da Caravaggio. Also on display is a working drawing for a design for an embroidered hood of a cope (cape) by Palma Giovane, depicting a scene from Revelation

Zeki, Semir

282

PressRelease|TheFitzwilliamMuseum Trumpington Street  

E-print Network

zones: depictions of soldiers and military life by Sargent and Spencer and their friends and associates depictions of nude female models · Spencer, God and love: an examination of Spencer's overarching themes

Zeki, Semir

283

Press Release EU-funded research collaboration on  

E-print Network

Hannover (Germany). These academic institutions cooperate with a number of specialized SMEs: Life & Brain is a devastating condition affecting over 50 million people worldwide. Current antiepileptic drugs provide only symptomatic relief, have multiple associated side effects, and are ineffective in 30- 40% of cases. Currently

Ferrari, Patrik L.

284

An Investigation into Managers' Language Use in Earnings Press Releases  

ERIC Educational Resources Information Center

For years, researchers have examined financial data in corporate earnings announcements and their influence on market participants. More recently, a body of research has been developing recognizing the impact of narrative disclosures and managers' deliberate language choices. However, no prior studies have investigated those language choices of

Riley, Tracey Jean

2011-01-01

285

PressRelease|TheFitzwilliamMuseum 24 July 2008  

E-print Network

of the site was heralded as early as 1876, when a newspaper report claimed that `every time it rains the water archaeological excavations in the land sought out by the Argonauts of Greek mythology The first ever UK found on the site, the Vani nobility were laid to rest wearing an array of gold and silver jewellery

Zeki, Semir

286

Press Releases and News Analysis: Asia ETF risk under watch  

E-print Network

and India. The ETFs also offer a cheap and effective hedge against existing stock portfolios. UBS stunned-traded funds positions, had racked up huge losses. London trader Kweku Adoboli was charged with fraud and false. These are derivative instruments such as stock index futures that are denominated in a currency other than the base

Chaudhuri, Sanjay

287

PressRelease|TheFitzwilliamMuseum 07 July 2010  

E-print Network

triumphant conquests to ­ finally - the destruction of the Persian Empire. Embellished with gold, lapis lazuli and other precious pigments, these manuscripts juxtapose fantastical portrayals of terrifying divs

Zeki, Semir

288

PressRelease|TheFitzwilliamMuseum Updated: 17 June 2011  

E-print Network

together a selection of fine prints from the Museum's collection, presenting works by artists from the 16th displayed together until now. Trumpington Street Cambridge CB2 1RB England 01223 332900 www brings together drawings from the 15th to the 20th centuries, from closely-observed portraits

Zeki, Semir

289

PressRelease|TheFitzwilliamMuseum 08 December 2010  

E-print Network

a selection of fine prints from the Museum's collection. Works on display are by artists from the 16th quality of the Museum's old master works on paper. Trumpington Street Cambridge CB2 1RB England 01223 to the 18th centuries, including Parmigianino, Guido Reni, Castiglione, Salvator Rosa, Giambattista Tiepolo

Zeki, Semir

290

Press Release Free Range Emerging Art Award Winner  

E-print Network

across five disciplines: fashion & textiles; design; photography & media; contemporary & fine art to develop my artistic career.' `I want to thank all the technical and academic staff at Leeds College of Art

Stell, John

291

PRESS RELEASE The Twenty-First Annual Gandhi Peace Festival  

E-print Network

featuring activities related to peace and justice and is open to all. Admission is free WHEN: Saturday, Canada WHY: Peace is more than absence of war. Peace is about poverty, environment, violence against women, racism, bullying in schools, and of course about national and international issues that affect

Hitchcock, Adam P.

292

PRESS RELEASE FROM NEUROPSYCHOPHARMACOLOGY (http://www.nature.com/npp)  

E-print Network

published in Neuropsychopharmacology. Animal studies have found that anesthesia causes nerve cell death. The children did not differ in tests measuring intelligence or behavior, but those who had received anesthesia

Cai, Long

293

PRESS RELEASE August 3, 2010 Contact: Dianne Carbonetta  

E-print Network

of products for the "paleo" diet, is one of the newest clients at the Rutgers Food Innovation Center (FIC, someone who is willing to offer advice whether it is fitness related (or) about nutrition, school or life," says Liberati. A large part of Steve's concerns center on the average diet of his club members

Garfunkel, Eric

294

APS/NIDDK Minority Travel Fellows Attend the 2008 APS Intersociety Meeting: The Integrative Biology of Exercise  

NSDL National Science Digital Library

This is an article from The Physiologist. The APS regularly awards Travel Fellowships for underrepresented minority scientists and students to attend APS scientific meetings with funds provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). These fellowships provide funds for registration, transportation, meals, and lodging. Seven fellows attended the APS Intersociety Meeting, The Biology of Exercise V in Hilton Head, SC from September 24-27, 2008.

2009-02-01

295

Charles Darwin University Press www.cdu.edu.au/cdupress About CDU Press2  

E-print Network

Dry Season 2009 Charles Darwin University Press www.cdu.edu.au/cdupress #12;About CDU Press2 Season 2009 Catalog CDU Press is the publishing house of Charles Darwin University. We publish books to read. Wendy Brady Chair, CDU Press Editorial Board Charles Darwin University Press www

296

Open Humanities Press  

NSDL National Science Digital Library

As more and more journals elect to move to an open-source model, it is delightful to learn about the existence of the Open Humanities Press (OHP). Their mission is "to make leading works of contemporary critical thought freely available worldwide." First-time visitors will want to look over the "About OHP" section before delving into the rest of the site. Afterwards, they should feel free to look through one of their seven journals, which include "Cosmos and History", "Culture Machine", "Film-Philosophy", and "Fibreculture". While all of the journals are worth a look, the "Film-Philosophy" journal is particularly compelling, and visitors can browse through issues back to 1997. Finally, visitors can also learn about submitting their work for consideration and also take in a few essays about the guiding principles and history of the OHP.

297

American Press Institute  

NSDL National Science Digital Library

The American Press Institute has been providing high-quality resources for practicing journalists for years, and now visitors with a penchant for the field can find out about some of these helpful materials on this site. While their homepage can be a bit visually hard to follow, the resources here are top-notch, and include some first-rate publications, such as âReaching Latino Audiencesâ and âWomen, Men and Newsroom Leadershipâ. The âJournalistâs Toolboxâ is a real find, as it contains a number of easy-to-use resources on such materials as copyediting, Iraq, and reporting on technology affairs. Additionally, there is a fine area dedicated to business journalism, including helpful hints on how best to deploy statistics in such pieces of writing. Overall, the site is extremely useful, and it is worth visiting several times.

2005-01-01

298

EIA new releases, November--December 1995  

SciTech Connect

Thus publication contains information compiled by the Energy information administration (EIA) on the following topics: heating fuel supplies; alternative fuel vehicles; natural gas production; clean air laws and coal transportation; EIA`s world Wide Web Site; EIA`s CD-ROM; Press Releases; Microfiched products; electronic publishing; new reports; machine-readable files; how to order EIA publications; and Energy Data Information Contracts.

NONE

1996-02-09

299

EIA new releases, July--August, 1995  

SciTech Connect

This publication identifies energy related publications of the Energy Information Administration of the US Department of Energy. The topics and articles in this issue include data on residential energy use available on diskettes and Internet, natural gas price predictions, coal deliveries to electric utilities, growth in the US uranium industry, microfiche products, features and press releases, EIA`s electronic publishing system, new reports, machine-readable files, how to order EIA publications and energy data information contacts.

NONE

1995-10-02

300

EPICS release 3.11.6 specific documentation -- Release notes for EPICS 3.11.6  

SciTech Connect

These notes cover the following: (1) directions for switching to production APS release R3.11.6; (2) unbundling of channel access clients; (3) access security; (4) channel access additions; synchronous time support; and (5) description of major differences between R3.11.3 and R3.11.6 Also included is a list of new and/or updated documentation for the program.

NONE

1994-06-07

301

Is the Shine off the A.P. Apple?  

ERIC Educational Resources Information Center

Describes challenges facing College Board's efforts to expand Advanced Placement (A.P.) courses to provide equal access to previously underserved low-performing urban and rural school students while maintaining the program's high academic standards. Includes list of strategies school boards can use to achieve greater access to A.P. courses while

Hurwitz, Nina; Hurwitz, Sol

2003-01-01

302

A Closer Examination of the Academic Benefits of AP  

ERIC Educational Resources Information Center

The authors sought to better understand the relationship between students participating in the Advanced Placement (AP) program and subsequent performance on the Scholastic Aptitude Test (SAT). Focusing on students graduating from U.S. public high schools in 2010, the authors used propensity scores to match junior year AP examinees in 3 subjects to

McKillip, Mary E. M.; Rawls, Anita

2013-01-01

303

AP-102/104 Retrieval control system qualification test procedure  

SciTech Connect

This Qualification Test Procedure documents the results of the qualification testing that was performed on the Project W-211, ''Initial Tank Retrieval Systems,'' retrieval control system (RCS) for tanks 241-AP-102 and 241-AP-104. The results confirm that the RCS has been programmed correctly and that the two related hardware enclosures have been assembled in accordance with the design documents.

RIECK, C.A.

1999-05-18

304

Development of a superconducting undulator for the APS  

NASA Astrophysics Data System (ADS)

As the western hemisphere's premier x-ray synchrotron radiation source, the Advanced Photon Source (APS) continues to advance the state of the art in insertion device technology in order to maintain record high brightness, especially in the hard x-ray wavelength region. Due to the unique bunch pattern used for normal APS operations and its ultimate capabilities, the APS has chosen superconducting technology for its future hard x-ray undulator sources. In the last several years, the APS in collaboration with the Budker Institute of Nuclear Physics has being developing the technology for planar, small-period superconducting undulators (SCUs). These developments include the design and construction of several prototypes and the construction of the necessary mechanical, vacuum, and cryogenic infrastructure at the APS site. Several prototypes of the SCU magnetic structure have been built and tested. The first SCU is assembled and will be installed in the APS storage ring at the end of 2012. Expected SCU performance in terms of x-ray brightness should noticeably exceed that of existing APS undulators. Immediately after commissioning, the SCU will be used at APS Sector 6 as the radiation source for high-energy x-ray studies.

Ivanyushenkov, Y.; Abliz, M.; Doose, C.; Fuerst, J.; Hasse, Q.; Kasa, M.; Lev, V.; Mezentsev, N.; Syrovatin, V.; Trakhtenberg, E.; Tsukanov, V.; Vasserman, I.; Gluskin, E.

2013-03-01

305

AP-42 ADDITIONS AND REVISIONS - PAVED AND UNPAVED ROAD DUST  

EPA Science Inventory

This project develops emission factors, etc., for paved and unpaved roads which are incorporated into AP-42. AP42 is a massive collection of material which describes processes which generate air emissions and presents emission factors and control effectiveness information. As re...

306

AP-42 ADDITIONS AND REVISIONS - LANDFILLS (COMBUSTION CONTROLS)  

EPA Science Inventory

This project develops emission factors, etc., for landfills, in particular for combustion devices fed by landfill gas, for incorporation into AP-42. AP-42 is a massive collection of information concerning processes which generate air emissions and presents emission factors and co...

307

STEP AP233 + Standard PDM = Systems Engineering PDM ?  

E-print Network

STEP AP233 + Standard PDM = Systems Engineering PDM ? Roland Eckert1 , Wolfgang Mansel2 , Günther engineering environment. STEP ISO 10303 - AP233 provides an appropriate approach for integrating systems. A framework for a systems engineering PDM system is proposed and data exchange aspects discussed

Ulm, Universität

308

Raising Rigor, Getting Results: Lessons Learned from AP Expansion  

ERIC Educational Resources Information Center

Advanced Placement (AP), which enables high school students to take introductory college-level courses, is the nation's oldest example of a rigorous, common curriculum. Students who score well on AP exams are more likely to persist in college and earn a degree. The Advanced Placement Expansion project of the National Governors Association Center

Wakelyn, David

2009-01-01

309

APS Storage Ring Injection Topics: Optimization and Topup  

E-print Network

APS Storage Ring Injection Topics: Optimization and Topup Louis Emery, Michael Borland and Vadim Accumulator Ring (PAR) 2 Hz, 7 GeV Booster Synchrotron Photocathode gun and injector Dual thermionic rf guns Proportional to jitter amplitude Proportional to bpm noise #12;11 APS Storage Ring DBAstyle cell with 5m

Ohta, Shigemi

310

APS team works smarter, cuts substation construction costs by 36%  

SciTech Connect

An aggressive, cost-cutting, team of T D employees at Arizona Public Service Co (APS) is building a new distribution substation in Phoenix for less than half the original cost that APS planners had calculated for the project's land, labor and materials. Scheduled for service in June of this year, APS analysts had originally projected land, labor and materials costs for the 20-MVA Bell substation at nearly $1.7-million-not including major equipment such as transformers, circuit breakers, and switches. However, after studying the project, an empowered APS crew was able to slash 36% off the original estimate-more than $610,000. What's more, APS spokesmen say that its new approach to substation construction and design has given its engineers and construction crews a laundry list of additional ideas to try out on future substation ventures. 4 figs., 1 tab.

Not Available

1993-05-01

311

AP2 hemicomplexes contribute independently to synaptic vesicle endocytosis  

PubMed Central

The clathrin adaptor complex AP2 is thought to be an obligate heterotetramer. We identify null mutations in the ? subunit of AP2 in the nematode Caenorhabditis elegans. ?-adaptin mutants are viable and the remaining ?2/? hemicomplex retains some function. Conversely, in ?2 mutants, the alpha/sigma2 hemicomplex is localized and is partially functional. ?-?2 double mutants disrupt both halves of the complex and are lethal. The lethality can be rescued by expression of AP2 components in the skin, which allowed us to evaluate the requirement for AP2 subunits at synapses. Mutations in either ? or ?2 subunits alone reduce the number of synaptic vesicles by about 30%; however, simultaneous loss of both ? and ?2 subunits leads to a 70% reduction in synaptic vesicles and the presence of large vacuoles. These data suggest that AP2 may function as two partially independent hemicomplexes. DOI: http://dx.doi.org/10.7554/eLife.00190.001 PMID:23482940

Gu, Mingyu; Liu, Qiang; Watanabe, Shigeki; Sun, Lin; Hollopeter, Gunther; Grant, Barth D; Jorgensen, Erik M

2013-01-01

312

The Pindar Press London 2009  

E-print Network

;Published by The Pindar Press 40 Narcissus Road London NW6 1TH · UK British Library Cataloguing a century ago, there raged two major international debates about rival claimants in wars of attribution

313

Using IB/AP exams to meet Honors College requirements Students who pass IB and AP exams will receive credit through the College of Charleston for the  

E-print Network

Using IB/AP exams to meet Honors College requirements Students who pass IB and AP exams to discuss IB/AP transfer credit and the courses that must be completed prior to graduation. The full list of IB and AP exams accepted by CofC can be found at http

Mitchener, W. Garrett

314

February 2006 5APS NEWS A Supplement to APS News Edited by Phillip F. Schewe, Ben Stein and Ernie Tretkoff  

E-print Network

February 2006 5APS NEWS A Supplement to APS News Edited by Phillip F. Schewe, Ben Stein and Ernie Tretkoff INTRODUCTION Physics News in 2005, a summary of physics highlights for the past year, was com- piled from items appearing in AIP's weekly newsletter Physics News Update, written by Phil Schewe

Tlusty, Tsvi

315

APS Position Statements- APS Guiding Principles for the Care and Use of Vertebrate Animals in Research and Training  

NSDL National Science Digital Library

The Guiding Principles for the Care and Use of Vertebrate Animals in Research and Training are an updated version of a document first adopted by the APS Council in 1953. The Guiding Principles represent a code of ethics for APS members who work with animals. They provide a framework intended to promote the humane treatment of animals and are also used to evaluate research submitted for publication in APS journals. The update is intended to clarify certain elements of the Guiding Principles and make them easier to apply in practical situations. In addition, because the Guiding Principles are based upon U.S. animal welfare requirements, the update adds provisions to address the fact that other countries have different animal welfare requirements. This change was needed because of the increasing number of physiologists from around the world who are joining the APS and submitting articles for publication in APS journals.

2010-07-16

316

Silver Buckle Press Collection  

NSDL National Science Digital Library

The University of Wisconsin's Digital Collections include everything from a tutorial in Icelandic to documents that tell the story of the Badger State's early settlement by Europeans. This particular collection brings together works by the Silver Buckle Press, which is a working museum of letterpress printing dedicated to preserving the craft of fine printing through educational programming, publications, exhibitions, and tours. The materials here include hard-to-find items from printing history, including "Hamilton's Wood Type" from 1901 and "The Nubian: a new fashion in types." This last work was created by the American Type Founders Company and it features "1928 Fashions in Type" with a focus on type faces that are "startling, eye-catching, attention-riveting and decidedly intriguing to the memory." There are over two dozen works in the collection, and visitors can search the complete text of all the items or just browse as they see fit. For students and lovers of graphic design, typography, advertising history, and related fields, this collection will be most enjoyable.

317

National Academy Press  

NSDL National Science Digital Library

Provided by the National Academy Press (NAP), the publishing arm of the National Academy of Science, National Academy of Engineering, Institute of Medicine, and the National Research Council (reviewed in the November 12, 1997 Scout Report for Science & Engineering), this outstanding resource will quickly become a favorite of scientists and researchers in a variety of fields. While there are numerous sites offering excerpts of new books and just as many containing the full text of out-of-copyright works, this site is unique in that it provides the full text of over 1000 recent, new, and even prepublication books from the NAP. The books are offered in several versions, including HTML, image format, and .pdf. Users may browse titles by subject or conduct a keyword search. Subjects include: Biology, Computer Sciences, Education, Mathematical Sciences and Statistics, Science and Ethics, and many others. Users can check the New Online page for the latest published and prepublication books added to the site or sign up for a free email notification service.

318

Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes.  

PubMed

Cell types that generate unique lysosome-related organelles (LROs), such as melanosomes in melanocytes, populate nascent LROs with cargoes that are diverted from endosomes. Cargo sorting toward melanosomes correlates with binding via cytoplasmically exposed sorting signals to either heterotetrameric adaptor AP-1 or AP-3. Some cargoes bind both adaptors, but the relative contribution of each adaptor to cargo recognition and their functional interactions with other effectors during transport to melanosomes are not clear. Here we exploit targeted mutagenesis of the acidic dileucine-based sorting signal in the pigment cell-specific protein OCA2 to dissect the relative roles of AP-1 and AP-3 in transport to melanosomes. We show that binding to AP-1 or AP-3 depends on the primary sequence of the signal and not its position within the cytoplasmic domain. Mutants that preferentially bound either AP-1 or AP-3 each trafficked toward melanosomes and functionally complemented OCA2 deficiency, but AP-3 binding was necessary for steady-state melanosome localization. Unlike tyrosinase, which also engages AP-3 for optimal melanosomal delivery, both AP-1- and AP-3-favoring OCA2 variants required BLOC-1 for melanosomal transport. These data provide evidence for distinct roles of AP-1 and AP-3 in OCA2 transport to melanosomes and indicate that BLOC-1 can cooperate with either adaptor during cargo sorting to LROs. PMID:22718909

Sitaram, Anand; Dennis, Megan K; Chaudhuri, Rittik; De Jesus-Rojas, Wilfredo; Tenza, Danile; Setty, Subba Rao Gangi; Wood, Christopher S; Sviderskaya, Elena V; Bennett, Dorothy C; Raposo, Graa; Bonifacino, Juan S; Marks, Michael S

2012-08-01

319

Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes  

PubMed Central

Cell types that generate unique lysosome-related organelles (LROs), such as melanosomes in melanocytes, populate nascent LROs with cargoes that are diverted from endosomes. Cargo sorting toward melanosomes correlates with binding via cytoplasmically exposed sorting signals to either heterotetrameric adaptor AP-1 or AP-3. Some cargoes bind both adaptors, but the relative contribution of each adaptor to cargo recognition and their functional interactions with other effectors during transport to melanosomes are not clear. Here we exploit targeted mutagenesis of the acidic dileucinebased sorting signal in the pigment cellspecific protein OCA2 to dissect the relative roles of AP-1 and AP-3 in transport to melanosomes. We show that binding to AP-1 or AP-3 depends on the primary sequence of the signal and not its position within the cytoplasmic domain. Mutants that preferentially bound either AP-1 or AP-3 each trafficked toward melanosomes and functionally complemented OCA2 deficiency, but AP-3 binding was necessary for steady-state melanosome localization. Unlike tyrosinase, which also engages AP-3 for optimal melanosomal delivery, both AP-1 and AP-3favoring OCA2 variants required BLOC-1 for melanosomal transport. These data provide evidence for distinct roles of AP-1 and AP-3 in OCA2 transport to melanosomes and indicate that BLOC-1 can cooperate with either adaptor during cargo sorting to LROs. PMID:22718909

Sitaram, Anand; Dennis, Megan K.; Chaudhuri, Rittik; De Jesus-Rojas, Wilfredo; Tenza, Danile; Setty, Subba Rao Gangi; Wood, Christopher S.; Sviderskaya, Elena V.; Bennett, Dorothy C.; Raposo, Graa; Bonifacino, Juan S.; Marks, Michael S.

2012-01-01

320

Pyrometry in the Multianvil Press: New approach for temperature measurement in large volume press experiments  

NASA Astrophysics Data System (ADS)

Temperature measurement in large volume press experiments has been based on thermocouple emf, which has well known problems: unknown pressure dependence of emf [e.g., 1], chemical reaction between thermocouple and other materials, deformation related texture development in the thermocouple wires [2], and so on. Thus, different techniques to measure temperatures in large volume press experiments other than thermocouples are required to measure accurate temperatures under high pressures. Here we report a new development using pyrometry in the multianvil press, where temperatures are derived on the basis of spectral radiometry. Several high pressure runs were conducted using the 1000 ton press with a DIA module installed at 13 ID-D GSECARS beamline at Advanced Photon Source (APS) [3]. The cubic pressure medium, 14 mm edge length, was made of soft-fired pyrophyllite with a graphite furnace. A moissanite (SiC) single crystal was built inside the pressure medium as a window for the thermal emission signal to go through. An MgO disk with 1.0 mm thickness was inserted in a gap between the top of the SiC crystal and thermocouple hot junction. The bottom of the window crystal was in direct contact with the tip of the anvil, which had a 1.5 mm diameter hole drilled all the way through the anvil axis. An optical fiber was inserted in this hole and the open end of fiber was in contact with the SiC crystal. Thermal spectral radiance from the inner cell assembly was obtained via the fiber and recorded by an Ocean Optics HP2000 spectrometer. The system response of spectrometer was calibrated by a tungsten ribbon ramp (OL550S, Optronic Laboratories, Inc.) with standard of spectral radiance. The cell assembly was compressed up to target value of 15 tons and then temperature was increased up to 1573 K. Radiation spectra were mainly obtained above 873 K and typical integration time was 1 ms or 10 ms. Data collection was done in the process of increase and decrease of temperature. In one in-situ X-ray experiment, pressures near the thermocouple were derived from the equations of state for gold [4] or MgO [5], and the pressure values varied up to approximately 1 GPa at various temperatures. Two different calculations were made to infer temperature based on pyrometry. One was made based on Planck radiation function and the other was made by the J-function, which was defined based on the law of Wien [6]. Calculated temperatures above about 1000 K were generally consistent with those obtained from the thermocouple emf. However, below about 1000 K, temperatures based on pyrometry in the process of increase of temperature were way off from those obtained by thermocouple emf. Recent results and future improvements will be discussed. Reference [1] I. C. Getting and G. C. Kennedy J. Appl. Phys., 41, 4552-4562, 1970. [2] J. Li, C. Hadidiacos, H.-K. Mao, Y. Fei and R. J. Hemley High Pressure Research, 23, 389-401, 2003. [3] Y. Wang, M. Rivers, S. Sutton, N. Nishiyama, T. Uchida, T. Sanehira Phys. Earth Planet. Inter. in press. [4] S.-H. Shim, T. S. Duffy and K. Takemura Earth Planet. Sci. Lett., 203, 729-739, 2002. [5] M. Matsui, S. C. Parker and M. Leslie Am. Mineral., 85, 312-316, 2000. [6] T. Yagi and J. Susaki, in High-Pressure Research: Application to Earth and Planetary Sciences, edited by Y. Syono and M. H. Manghnani, pp.51-54, TERRAPUB, Tokyo / AGU, Washington D.C., 1992.

Sanehira, T.; Wang, Y.; Prakapenka, V.; Rivers, M. L.

2008-12-01

321

Abnormal expression of transcription factor AP-2? in pathologic placentas*  

PubMed Central

Summary Recent studies from our laboratory have indicated that the transcription factor AP-2? plays a critical role in the differentiation of human villous cytotrophoblast cells (CTB) to syncytiotrophoblast cells (STB). However, little is known about the expression of AP-2? in placentas from pathologic pregnancies. This study compares the expression of AP-2? in placentas from high-risk pregnancies to gestational age-matched controls. Paracentral sections from grossly unremarkable areas of 10 placentas from each group of pregnancies complicated by mild preeclampsia (PE), severe PE, diabetes mellitus (DM), chronic hypertension (HTN), fetal growth restriction (FGR) and 10 control cases of placentas from normal pregnancies matched for gestational age (CG) were double immunostained for AP-2? and E-cadherin. The total numbers of CTB and STB and the numbers of AP-2? positive and negative nuclei in both of these cell types were counted by two pathologists blinded to disease status, in ten representative 40x fields (HPF) for each placenta. Abnormal placental maturation in most of pathologic pregnancies was evidenced by a 1.51.7-fold lower STB to CTB ratio. AP-2? expression in STB was lower in mild PE, DM, HTN and FGR (p<0.0001 in each instance) and was higher by 2-fold in severe PE, though this increase was not statistically significant (p=0.3). Since AP-2? has been shown to be critical for villous CTB differentiation, our findings suggest that abnormalities in the AP-2? cascade of transcription factors and/or signaling molecules may contribute to the pathogenesis of the abnormal maturation in placentas in certain types of high-risk pregnancies. The different pattern of AP-2? expression in mild and severe PE clearly suggests that these conditions may have two independent pathogenic mechanisms. PMID:22575257

Sheridan, Rachel M.; Stanek, Jerzy; Khoury, Jane; Handwerger, Stuart

2012-01-01

322

Fast regulation of AP-1 activity through interaction of lamin A/C, ERK1/2, and c-Fos at the nuclear envelope  

PubMed Central

Sequestration of c-Fos at the nuclear envelope (NE) through interaction with A-type lamins suppresses AP-1dependent transcription. We show here that c-Fos accumulation within the extraction-resistant nuclear fraction (ERNF) and its interaction with lamin A are reduced and enhanced by gain-of and loss-of ERK1/2 activity, respectively. Moreover, hindering ERK1/2-dependent phosphorylation of c-Fos attenuates its release from the ERNF induced by serum and promotes its interaction with lamin A. Accordingly, serum stimulation rapidly releases preexisting c-Fos from the NE via ERK1/2-dependent phosphorylation, leading to a fast activation of AP-1 before de novo c-Fos synthesis. Moreover, lamin Anull cells exhibit increased AP-1 activity and reduced levels of c-Fos phosphorylation. We also find that active ERK1/2 interacts with lamin A and colocalizes with c-Fos and A-type lamins at the NE. Thus, NE-bound ERK1/2 functions as a molecular switch for rapid mitogen-dependent AP-1 activation through phosphorylation-induced release of preexisting c-Fos from its inhibitory interaction with lamin A/C. PMID:19015316

Gonzlez, Jos Mara; Navarro-Puche, Ana; Casar, Berta; Crespo, Piero; Andrs, Vicente

2008-01-01

323

KCAT, Xradia, ALS and APS Performance Summary  

SciTech Connect

At Lawrence Livermore National Laboratory (LLNL) particular emphasis is being placed on the nondestructive characterization (NDC) of components, subassemblies and assemblies of millimeter-size extent with micrometer-size features (mesoscale). These mesoscale objects include materials that vary widely in composition, density, geometry and embedded features. Characterizing these mesoscale objects is critical for corroborating the physics codes that underlie LLNL's Stockpile Stewardship mission. In this report we present results from our efforts to quantitatively characterize the performance of several x-ray systems in an effort to benchmark existing systems and to determine which systems may have the best potential for our mesoscale imaging needs. Several different x-ray digital radiography (DR) and computed tomography (CT) systems exist that may be applicable to our mesoscale object characterization requirements, including microfocus and synchrotron systems. The systems we have benchmarked include KCAT (LLNL developed) and Xradia {mu}XCT (Xradia, Inc., Concord, CA), both microfocus systems, and Beamline 1-ID at the Advance Photon Source (APS) and the Tomography Beamline at the Advanced Light Source (ALS), both synchrotron based systems. The ALS Tomography Beamline is a new installation, and the data presented and analyzed here is some of the first to be acquired at the facility. It is important to note that the ALS system had not yet been optimized at the time we acquired data. Results for each of these systems has been independently documented elsewhere. In this report we summarize and compare the characterization results for these systems.

Waters, A; Martz, H; Brown, W

2004-09-30

324

High Pressure Reverse Flow APS Engine  

NASA Technical Reports Server (NTRS)

A design and test demonstration effort was undertaken to evaluate the concept of the reverse flow engine for the APS engine application. The 1500 lb (6672 N) thrust engine was designed to operate on gaseous hydrogen and gaseous oxygen propellants at a mixture ratio of 4 and to achieve the objective performance of 435 sec (4266 Nsec/kg) specific impulse. Superimposed durability requirements called for a million-cycle capability with 50 hours duration. The program was undertaken as a series of tasks including the initial preliminary design, design of critical test components and finally, the design and demonstration of an altitude engine which could be used interchangeably to examine operating parameters as well as to demonstrate the capability of the concept. The program results are reported with data to indicate that all of the program objectives were met or exceeded within the course of testing on the program. The analysis effort undertaken is also reported in detail and supplemented with test data in some cases where prior definitions could not be made. The results are contained of these analyses as well as the test results conducted throughout the course of the program. Finally, the test data and analytical results were combined to allow recommendations for a flight weight design. This preliminary design effort is also detailed.

Senneff, J. M.

1972-01-01

325

ENGINEERING & SCIENCE wi nte r 201122 You'd be hard pressed to find an organ-  

E-print Network

give rise to all these different non-nerve-cell types?" Bronner asks. To help answer those questionsENGINEERING & SCIENCE wi nte r 201122 You'd be hard pressed to find an organ- ism that- ner says, into "giant bags of gametes," or eggs and sperm, which are released into the water

326

Internet: http://ue.eu.int E-mail: press.office@consilium.eu.int  

E-print Network

- COMPETITIVENESS - (Internal market, Industry and Research) Brussels, 26 November 2003 President : Mrs Letizia THIS PRESS RELEASE COVERS ITEMS DISCUSSED ON 26.11.2003 - RESEARCH ONLY - 2547th Council meeting MORATTI, Minister for Education, the Universities and Research of the Italian Republic #12;PROVISIONAL

327

Development of Emergency Response Guidelines (ERGs) for AP1000  

SciTech Connect

The AP1000 is two-loop 1100 MWe advanced pressurized water reactor (PWR) that uses passive safety features to enhance plant safety and to provide significant and measurable improvements in plant simplification, reliability, investment protection and plant costs. The AP1000 uses proven technology, which builds on over 30 years of operating PWR experience. The AP1000 final design certification has been approved by the NRC in December, 2005. The Emergency Response Guidelines (ERGs) have been developed for the AP1000. The generic ERGs for the low pressure reference PWR plant were used as the basic documents to develop the AP1000 ERGs. The AP1000 design differences from the reference plant were reviewed and reflected in the process of developing operational steps in each ERG. The AP1000 used PRA in both design and licensing. The provisions of the AP1000 PRA were also reviewed and incorporated into the ERGs Although the AP1000 design does not require operator actions for the first 72 hours after accidents, the operator actions with both safety-related and non-safety-related equipment have an important role to mitigate the consequence of accidents. In the event of a LOCA, the AP1000 safety-related passive core cooling system (PXS) provides sources of core makeup water along with an automatic depressurization system (ADS) consisting of several sets of redundant flow paths which are sequentially opened in stages to reduce the reactor coolant system (RCS) pressure in a controlled manner. The final stage of this system, ADS-4, consists of four large valves that open off the hot legs, reducing the pressure to allow gravity injection from the in-containment refueling water storage tank (IRWST) and eventually the containment sump recirculation. The AP1000 has non-safety-related normal residual heat removal system (RNS) pumps which can be used to provide low pressure pumped injection of cask loading pit and/or IRWST water and recirculation of containment water. These pumps are not required to operate following accidents. However, it is expected that they should be used if available and their operator actions should be incorporated into ERGs to restore safety-related PXS and/or to avoid ADS-4 actuation. Several LOCA and other cases were analyzed, including consideration of such operator actions as RNS injection, to support the development process of the AP1000 ERGs. These cases were modeled using the best-estimate state-of-art RELAP5 code. The analyses results show that RNS injection is effective for a typical small LOCA to avoid ADS-4 actuation. (authors)

Yuichi Hayashi [Kansai Electric Power Co., Inc., P.O. Box 355, Pittsburgh, PA, 15230-0355 (United States); Saiu, Gianfranco [ANSALDO NUCLEARE S.p.A, P.O. Box 355, Pittsburgh, PA, 15230-0355 (United States); Wright, Richard F. [Westinghouse Electric Company, LLC, P.O. Box 355, Pittsburgh, PA, 15230-0355 (United States)

2006-07-01

328

Simultaneous recording of t-tubular electrical activity and Ca2+-release in heart failure  

NASA Astrophysics Data System (ADS)

T-tubules (TT) are invaginations of the surface sarcolemma (SS) that mediate the rapid propagation of the action potential (AP) to the cardiomyocyte core. We employed the advantages of an ultrafast random access multi-photon (RAMP) microscope (Sacconi et al., PNAS 2012) with a double staining approach to optically record t-tubular AP and, simultaneously, the corresponding local Ca2+-release in different positions across the cardiomyocytes. Despite a uniform AP between SS and TT at steady-state stimulation, in control cardiomyocytes we observed a non-negligible be variability of local Ca2+-transient amplitude and kinetics. This variability was significantly reduced by applying 0.1?M Isoproterenol, which increases the opening probability of Ca2+-release units. In the rat heart failure model (HF), we previously demonstrated that some tubular elements fail to propagate AP. We found that the tubules unable to propagate AP, displayed a reduced correspondent Ca2+-transient amplitude as well as a slower Ca2+ rise compared to electrically coupled tubules. Moreover variability of Ca2+-transient kinetics were increased in HF. Finally, TT that did not show AP, occasionally exhibited spontaneous depolarizations that were never accompanied by local Ca2+-release in the absence of any pro-arrhythmogenic stimulation. Simultaneous recording of AP and Ca2+-transient allows us to probe the spatio-temporal variability of Ca2+-release, whereas the investigation of Ca2+-transient in HF discloses an unexpected uncoupling between t-tubular depolarization and Ca2+-release in remodeled tubules. This work was funded by the European Union 7th Framework Program (FP7/2007- 2013) under grant agreement n 284464, 241526, by the Italian Ministry of University and Research (NANOMAX), and by Telethon-Italy (GGP13162).

Crocini, C.; Coppini, R.; Ferrantini, C.; Yan, P.; Loew, L.; Tesi, C.; Poggesi, C.; Cerbai, E.; Pavone, F. S.; Sacconi, L.

2014-05-01

329

Improving Dryer and Press Efficiencies Through Combustion of Hydrocarbon Emissions  

SciTech Connect

Emission control devices on dryers and presses have been legislated into the industry, and are now an integral part of the drying system. These devices consume large quantities of natural gas and electricity and down-sizing or eliminating them will provide major energy savings. The principal strategy taken here focuses on developing process changes that should minimize (and in some cases eliminate) the need for controls. A second approach is to develop lower-cost control options. It has been shown in laboratory and full-scale work that Hazardous Air Pollutants (HAPs) emerge mainly at the end of the press cycle for particleboard, and, by extension, to other prod-ucts. Hence, only the air associated with this point of the cycle need be captured and treated. A model for estimating terpene emissions in the various zones of veneer dryers has been developed. This should allow the emissions to be concentrated in some zones and minimized in others, so that some of the air could be directly released without controls. Low-cost catalysts have been developed for controlling HAPs from dryers and presses. Catalysts conventionally used for regenerative catalytic oxidizers can be used at much lower temperatures for treating press emissions. Fluidized wood ash is an especially inexpensive mate-rial for efficiently reducing formaldehyde in dryer emissions. A heat transfer model for estimating pinene emissions from hot-pressing strand for the manufacture of flakeboard has been constructed from first principles and validated. The model shows that most of the emissions originate from the 1-mm layer of wood adjoining the platen surface. Hence, a simple control option is to surface a softwood mat with a layer of hardwood prior to pressing. Fines release a disproportionate large quantity of HAPs, and it has been shown both theo-retically and in full-scale work that particles smaller than 400 ???µm are principally responsible. Georgia-Pacific is considering green-screening their furnish at several of their mills in order to remove these particles and reduce their treatment costs.

Sujit Banerjee

2005-10-31

330

An AP4B1 frameshift mutation in siblings with intellectual disability and spastic tetraplegia further delineates the AP-4 deficiency syndrome.  

PubMed

The recently proposed adaptor protein 4 (AP-4) deficiency syndrome comprises a group of congenital neurological disorders characterized by severe intellectual disability (ID), delayed or absent speech, hereditary spastic paraplegia, and growth retardation. AP-4 is a heterotetrameric protein complex with important functions in vesicle trafficking. Mutations in genes affecting different subunits of AP-4, including AP4B1, AP4E1, AP4S1, and AP4M1, have been reported in patients with the AP-4 deficiency phenotype. We describe two siblings from a non-consanguineous couple who presented with severe ID, absent speech, microcephaly, growth retardation, and progressive spastic tetraplegia. Whole-exome sequencing in the two patients identified the novel homozygous 2-bp deletion c.1160_1161delCA (p.(Thr387Argfs*30)) in AP4B1. Sanger sequencing confirmed the mutation in the siblings and revealed it in the heterozygous state in both parents. The AP4B1-associated phenotype has previously been assigned to spastic paraplegia-47. Identification of a novel AP4B1 alteration in two patients with clinical manifestations highly similar to other individuals with mutations affecting one of the four AP-4 subunits further supports the observation that loss of AP-4 assembly or functionality underlies the common clinical features in these patients and underscores the existence of the clinically recognizable AP-4 deficiency syndrome. PMID:24781758

Abdollahpour, Hengameh; Alawi, Malik; Kortm, Fanny; Beckstette, Michael; Seemanova, Eva; Komrek, Vladimr; Rosenberger, Georg; Kutsche, Kerstin

2015-02-01

331

An improved model for the combustion of AP composite propellants  

NASA Technical Reports Server (NTRS)

This paper presents several improvements to the BDP model of steady-state burning of AP composite solid propellants. The Price-Boggs-Derr model of AP monopropellant burning is incorporated to represent the AP. A separate energy equation is written for the binder to permit a different surface temperature from the AP; this includes an analysis of the sharing of primary diffusion flame energy, and correction of a BDP model inconsistency in treating the binder regression rate. A method for assembling component contributions to calculate the burning rates of multimodal propellants is also presented. Results are shown in the form of representative burning rate curves, comparisons with data, and calculated internal details of interest. Ideas for future work are discussed in an Appendix.

Cohen, N. S.; Strand, L. D.

1981-01-01

332

APS-2007 Elena Aprile First Results from the  

E-print Network

module. Current plan is to have a 100kg LXe dark matter experiment taking data in 2009. XENON neutron calibration with AmBe source #12;APS-2007 Elena Aprile Pulse tube cryocooler 15 kg LXe The XENON10

Golwala, Sunil

333

A Review of AP Calculus Graphing Calculator Skills  

NSDL National Science Digital Library

Review material on graphing calculator use from the College Board AP Calculus Course Description. The problems are mostly AB level. The page also contains a brief historical remark about Maria Gaetana Agnesi.

334

Tune measurement in the APS ring  

SciTech Connect

The APS system will contain three rings. The first is a positron accumulator ring (PAR). Its function is to coalesce 24, 30-ns-long positron bunches into one 290-ps bunch. The second is the injector synchrotron (IS). It accelerates the 450-MeV positron bunches to 7 Gev for injection into the storage ring (SR). Betatron and synchrotron motion frequently occurs in circular machines, without any deliberate excitation. However, the amplitudes of this motion cannot be predicted. Therefore, it is desirable to have controlled ways to excite these modes. Two types of devices will be used to excite the beam. One will be a magnetic kicker or bumper. All rings already have these devices planned for the horizontal direction for injecting and extracting beams. Some of these magnets will be used for exiting horizontal betatron motion. In the storage ring, a special kicker will be installed to produce up to 1 mm amplitude motion in the vertical direction. Two 8.4-in striplines (SL) (1/4 wavelength at 352 MHz) will be installed on all rings. One stripline in each ring will be used to drive all three tunes, and the other stripline will be used as a pickup. In the PAR and IS, the pickup stripline will be in a dispersive region. This will allow observation of both betatron and synchrotron motions. In the SR, the stripline will be in a nondispersive region because it is not practical to install it in a dispersive region. To do synchrotron tune measurements in the SR, one of the button BPMs located in a dispersive region will be used. To minimize development effort, as much of the BPM system electronics as possible will be used in the tune measurement system. The BPM electronics uses the AMP/PM conversion technique. This system operates at 352 MHz. Thus, tune measurement components were also designed to operate at 352 MHz.

Sellyey, W.; Kahana, E.; Wang, X.

1993-07-01

335

28 CFR 540.64 - Press pools.  

Code of Federal Regulations, 2013 CFR

...PERSONS IN THE COMMUNITY Contact With News Media 540.64 Press pools...press pool, the Warden shall notify all news media representatives who have requested... (1) The national and international news services; (2) The television and...

2013-07-01

336

28 CFR 540.64 - Press pools.  

...PERSONS IN THE COMMUNITY Contact With News Media 540.64 Press pools...press pool, the Warden shall notify all news media representatives who have requested... (1) The national and international news services; (2) The television and...

2014-07-01

337

28 CFR 540.64 - Press pools.  

Code of Federal Regulations, 2011 CFR

...PERSONS IN THE COMMUNITY Contact With News Media 540.64 Press pools...press pool, the Warden shall notify all news media representatives who have requested... (1) The national and international news services; (2) The television and...

2011-07-01

338

28 CFR 540.64 - Press pools.  

Code of Federal Regulations, 2012 CFR

...PERSONS IN THE COMMUNITY Contact With News Media 540.64 Press pools...press pool, the Warden shall notify all news media representatives who have requested... (1) The national and international news services; (2) The television and...

2012-07-01

339

Status of Potential New Commercial Nuclear Reactors in the United Release Date: December 2007  

E-print Network

1 Status of Potential New Commercial Nuclear Reactors in the United States Release Date: December for building new nuclear power reactors in the United States. Evidence of this includes press releases and conditionally operate new commercial nuclear reactors. Actual applications will also be included on future

Noble, James S.

340

The Princess and the Press  

NSDL National Science Digital Library

After the tragic death of Princess Diana recently, there was much controversy over the role of the press as an intrusive force that helped lead to her demise. PBS Frontline, in a companion site to a recent TV documentary on the relationship between the English press and monarchy, examines this controversy in detail. Interviews with thirteen journalists, including Andrew Morton, who wrote a controversial biography of the late Princess; a transcript of Diana's Interview with the BBC in 1995; selected tabloid pictures and headlines; and a timeline illustrating British royalty encounters with the press are featured. A transcript of the show will be available shortly. As always, Frontline tackles controversial issues, and while some users may not agree with the tone or conclusions of the show (and site), there is a gold mine of information on the topic here.

1997-01-01

341

Again, Maryland Ranks #1 in Advanced Placement (AP) Exam Performance  

ERIC Educational Resources Information Center

For a second year in a row, Maryland ranked first nationwide in the percentage of public school students scoring 3 or higher on at least one AP (Advanced Placement) exam. A score of 3 or higher on the 5-point scale is considered mastery of college-level work. Maryland also continues to show strong gains in the number of students taking an AP exam,

Maryland State Department of Education, 2010

2010-01-01

342

The role of AP1 in glucocorticoid resistance in leukaemia  

Microsoft Academic Search

Glucocorticoids are used in the treatment of acute lymphoblastic leukaemia (ALL) and chronic lymphocytic leukaemia (CLL) but many patients develop glucocorticoid resistance on relapse. The ligand-activated glucocorticoid receptor inhibits activity of the AP-1 transcription factor and the purpose of this study was to test the hypothesis that up-regulation or over-expression of AP1-binding activity may be an important mechanism of glucocorticoid

S Bailey; AG Hall; ADJ Pearson; CPF Redfern

2001-01-01

343

APS Investigative Systems Associated with County Reported Domestic Elder Abuse  

Microsoft Academic Search

Objectives: To evaluate the association between state-defined elder abuse investigation systems and rates of reported, investigated and substantiated domestic elder abuse.Methods: A mailed survey was administered to 1,763 adult protective service (APS) office investigators in 44 states and the District of Columbia. Information about investigative structures and investigations was obtained from 1,409 of the APS investigators, an 80% return rate.

Gerald J. Jogerst; Jeanette M. Daly; Jeffrey D. Dawson; Margaret F. Brinig; Gretchen A. Schmuch; Corinne Peek-Asa

2005-01-01

344

An Efficient, Easily Constructed Cell Homogenizing Press  

PubMed Central

An easily constructed, highly efficient cell homogenizing press is described which should be available to laboratories at moderate cost. The press allows the preparation of homogenates from up to 20 g of packed cell paste in a single batch without danger of damage to the press. Cell breakage and recovery of cell homogenates is accomplished at temperatures which maintain the material in the frozen state. The press may be assembled, disassembled, and cleaned with minimal effort. Images FIG. 2 FIG. 3 PMID:14496011

Sagers, Richard D.

1962-01-01

345

The Small Book Press: A Cultural Essential.  

ERIC Educational Resources Information Center

Discussion of small literary book publishers notes works of small-press authors (Thomas Paine, Washington Irving, Walt Whitman, Mark Twain, Upton Sinclair, Anais Nin); today's outstanding presses (Creative Arts Book Company, Persea Books, Full Court Press, Reed and Cannon Company, Tuumba Books); and role of little magazines. Thirty-seven

Henderson, Bill

1984-01-01

346

The VLT LBG Redshift Survey - I. Clustering and dynamics of &ap;1000 galaxies at z&ap; 3  

Microsoft Academic Search

We present the initial imaging and spectroscopic data acquired as part of the Very Large Telescope (VLT) VIMOS Lyman-break galaxy Survey. UBR (or UBVI) imaging covers five &ap;36 36 arcmin2 fields centred on bright z > 3 quasi-stellar objects (QSOs), allowing &ap;21 000 2 < z 2 Lyman-break galaxies and 10 z > 2 QSOs from a total of

R. M. Bielby; T. Shanks; P. M. Weilbacher; L. Infante; N. H. M. Crighton; C. Bornancini; N. Bouch; P. Hraudeau; D. G. Lambas; J. Lowenthal; D. Minniti; N. Padilla; P. Petitjean; T. Theuns

2011-01-01

347

Past, Present, and Future of AP Chemistry: A Brief History of Course and Exam Alignment Efforts  

ERIC Educational Resources Information Center

As part of the Advanced Placement (AP) Program's commitment to continually enhance alignment with current best practices in college-level learning, the AP Program is currently evaluating and redesigning courses and exams, one of which launched during the 2013-2014 academic school year: AP chemistry. The history of the AP chemistry course and

Magrogan, Serena

2014-01-01

348

The Secret Gripes of Professor Klein: An AP-IB By Jay Mathews  

E-print Network

The Secret Gripes of Professor Klein: An AP-IB Drama By Jay Mathews Washington Post Staff Writer's analysis of AP and IB did not turn out the way either of them hoped. On June 4, Klein submitted his report on two courses, AP Calculus AB and IB Mathematics SL. Klein's analysis of AP and IB math was more

Klein, David

349

Press Release For immediate release Putting on too much weight in pregnancy  

E-print Network

of disease and health related outcomes, including cardiovascular disease, obesity, diabetes, cancer, mental the associations between pre-pregnancy weight and weight gain in pregnancy with cardiovascular disease risk factors of weight gain in pregnancy. "What the ideal weight gain is in pregnancy is a much debated question

Bristol, University of

350

Gifted Education Press Quarterly, 1995.  

ERIC Educational Resources Information Center

This document consists of the four issues of the newsletter "Gifted Education Press Quarterly" published during 1995. This newsletter addresses issues in the education of gifted children and youth. The major articles are: (1) "Using Today's Technology: Parents Can Help Challenge Gifted Children" (Adrienne O'Neill); (2) "Outcomes-Based Education

Fisher, Maurice D., Ed.

1995-01-01

351

ARTICLE IN PRESS Aerosol Science ( )  

E-print Network

ARTICLE IN PRESS Aerosol Science ( ) ­ www.elsevier.com/locate/jaerosci Langevin PDF simulation, for example thermal and nuclear systems, cyclone separators, spray cooling and which is also present.-P. Langevin PDF simulation of particle deposition in a turbulent pipe flow. Journal of Aerosol Science (2008

Chibbaro, Sergio

352

Neuroscience 2013 The MIT Press  

E-print Network

Neuroscience 2013 The MIT Press 30% Discount Offer (See details on order form) #12;NEW BORGES core fields of study, including artificial intelligence, linguistics, neuroscience, psychology information, please contact: cognet-info@mit.edu #12;1 neuroscience · Honorable Mention, 2010 PROSE Award

Jackson, Daniel

353

de Madagascar Dossier de presse  

E-print Network

Lémuriens de Madagascar Dossier de presse #12;Lémuriens de Madagascar -- 2 -- Les Publications scientifiques du Muséum & Conservation International présentent Lémuriens de Madagascar de Russell A, Lému- riens de Madagascar est publié par les Publica- tions scientifiques du Muséum national d

354

The Pindar Press London 2009  

E-print Network

The Pindar Press London 2009 Visible Spirit The Art of Gianlorenzo Bernini Vol. II Irving Lavin #12 and the Reverse of the Medal 1087 XXVIII The Young Bernini 1127 #12;XXIX `Bozzetto Style': The Renaissance' The Renaissance Sculptor's Handiwork* IT takes most people much time and effort to become proficient

355

NATIONAL ACADEMY PRESS WEB SITE  

EPA Science Inventory

The National Academy Press is the publisher for the National Academy of Sciences, the National Academy of Engineering, the Institute of Medicine, and the National Research Council. Through this web site, you have access to a virtual treasure trove of books, reports and publicatio...

356

ARTICLE IN PRESS Pattern Recognition ( )  

E-print Network

ARTICLE IN PRESS Pattern Recognition ( ) ­ www.elsevier.com/locate/patcog The method of N-grams on the comparison of vocabularies of N-grams. In contrast to the regular N-grams approach, the proposed N-grams method is based on calculation of imperfect occurrences of N-grams in a text up to a number of mismatched

Kirzhner Valery

357

Book Editors IOS Press, 2003  

E-print Network

Book Title Book Editors IOS Press, 2003 1 Hybrid Analysis of a Spherical Mechanism for a Minimally reward good kinematic performance, and dynamic performance metrics, which penalize poor dynamic performance. Kinematic and dynamic metrics are considered indepen- dently, and then combined to produce hybrid

358

Contact Information: Governor's Press Office  

E-print Network

Technology of Red Bank, New Jersey will expand its footprint and add 27 new jobs as part of an expansion growth to a facilitator of new business and private sector job development." Natcore's home, Eastman: 518.474.8418 press.office@exec.ny.gov Andrew M. Cuomo ­ Governor Governor Cuomo Announces New Jobs

Richards-Kortum, Rebecca

359

EPICS Input/Output Controller (IOC) application developer`s guide. APS Release 3.12  

SciTech Connect

This document describes the core software that resides in an Input/Output Controller (IOC), one of the major components of EPICS. The basic components are: (OPI) Operator Interface; this is a UNIX based workstation which can run various EPICS tools; (IOC) Input/Output Controller; this is a VME/VXI based chassis containing a Motorola 68xxx processor, various I/O modules, and VME modules that provide access to other I/O buses such as GPIB, (LAN), Local Area Network; and this is the communication network which allows the IOCs and OPIs to communicate. Epics provides a software component, Channel Access, which provides network transparent communication between a Channel Access client and an arbitrary number of Channel Access servers.

Kraimer, M.R.

1994-11-01

360

Biological Sciences -Neuroscience Loss of AP3 function affects spontaneous and evoked release at  

E-print Network

", INSERM Avenir Team, Paris, F-75005 France; Institut Jacques Monod, CNRS UMR7592, Universitities Paris 6 author: Thierry Galli, Institut Jacques Monod, 2, place Jussieu, F-75251 Paris Cedex 05, France, mailto

Paris-Sud XI, Université de

361

Mars Observer Press Conference JPL  

NASA Astrophysics Data System (ADS)

The Mars Observer mission spacecraft was primarily designed for exploring Mars and the Martian environment. The Mars Observer was launched on September 25, 1992. The spacecraft was lost in the vicinity of Mars on August 21, 1993 when the spacecraft began its maneuvering sequence for Martian orbital insertion. This videotape shows a press briefing, held after the spacecraft had not responded to attempts to communicate with it, to explain to the press the problems and the steps that were being taken to re-establish communication with the spacecraft. The communications had been shutdown prior to the orbital insertion burn to protect the instruments. At the time of the press conference, the communications system was still not operational, and attempts were being made to re-establish communication. Bob McMillan of the Public Affairs Office at JPL gives the initial announcement of the continuing communication problem with the spacecraft. Mr. McMillan introduces William Piotrowski, acting director of solar system exploration, who reiterates that there is indeed no communication with the Observer spacecraft. He is followed by Glenn Cunningham, the Project Manager of the Mars Observer who speaks about the attempts to re-establish contact. Mr. Cunningham is followed by Satenios Dallas, the Mission Manager for the Mars Observer Project, who speaks about the sequence of events leading up to the communication failure, and shows an animated video presenting the orbital insertion maneuvers. The briefing was then opened up for questions from the assembled press, both at JPL and at the other NASA Centers. The questions are about the possible reasons for the communication failure, and the attempts to restore communications with the spacecraft. Dr. Arden L. Albee, chief scientist for the Mars Observer Mission, joins the other panel members to answer questions. At the end of the press briefing the animation of the Mars orbital insertion is shown again.

1993-08-01

362

Mars Observer Press Conference JPL  

NASA Technical Reports Server (NTRS)

The Mars Observer mission spacecraft was primarily designed for exploring Mars and the Martian environment. The Mars Observer was launched on September 25, 1992. The spacecraft was lost in the vicinity of Mars on August 21, 1993 when the spacecraft began its maneuvering sequence for Martian orbital insertion. This videotape shows a press briefing, held after the spacecraft had not responded to attempts to communicate with it, to explain to the press the problems and the steps that were being taken to re-establish communication with the spacecraft. The communications had been shutdown prior to the orbital insertion burn to protect the instruments. At the time of the press conference, the communications system was still not operational, and attempts were being made to re-establish communication. Bob McMillan of the Public Affairs Office at JPL gives the initial announcement of the continuing communication problem with the spacecraft. Mr. McMillan introduces William Piotrowski, acting director of solar system exploration, who reiterates that there is indeed no communication with the Observer spacecraft. He is followed by Glenn Cunningham, the Project Manager of the Mars Observer who speaks about the attempts to re-establish contact. Mr. Cunningham is followed by Satenios Dallas, the Mission Manager for the Mars Observer Project, who speaks about the sequence of events leading up to the communication failure, and shows an animated video presenting the orbital insertion maneuvers. The briefing was then opened up for questions from the assembled press, both at JPL and at the other NASA Centers. The questions are about the possible reasons for the communication failure, and the attempts to restore communications with the spacecraft. Dr. Arden L. Albee, chief scientist for the Mars Observer Mission, joins the other panel members to answer questions. At the end of the press briefing the animation of the Mars orbital insertion is shown again.

1993-01-01

363

Autosomal recessive spastic tetraplegia caused by AP4M1 and AP4B1 gene mutation: expansion of the facial and neuroimaging features.  

PubMed

Adaptor protein complex-4 (AP4) is a component of intracellular transportation of proteins, which is thought to have a unique role in neurons. Recently, mutations affecting all four subunits of AP4 (AP4M1, AP4E1, AP4S1, and AP4B1) have been found to cause similar autosomal recessive phenotype consisting of tetraplegic cerebral palsy and intellectual disability. The aim of this study was analyzing AP4 genes in three new families with this phenotype, and discussing their clinical findings with an emphasis on neuroimaging and facial features. Using homozygosity mapping followed by whole-exome sequencing, we identified two novel homozygous mutations in AP4M1 and a homozygous deletion in AP4B1 in three pairs of siblings. Spastic tetraplegia, microcephaly, severe intellectual disability, limited speech, and stereotypic laughter were common findings in our patients. All patients also had similar facial features consisting of coarse and hypotonic face, bitemporal narrowing, bulbous nose with broad nasal ridge, and short philtrum which were not described in patients with AP4M1 and AP4B1 mutations previously. The patients presented here and previously with AP4M1, AP4B1, and AP4E1 mutations shared brain abnormalities including asymmetrical ventriculomegaly, thin splenium of the corpus callosum, and reduced white matter volume. The patients also had hippocampal globoid formation and thin hippocampus. In conclusion, disorders due to mutations in AP4 complex have similar neurological, facial, and cranial imaging findings. Thus, these four genes encoding AP4 subunits should be screened in patients with autosomal recessive spastic tetraplegic cerebral palsy, severe intellectual disability, and stereotypic laughter, especially with the described facial and cranial MRI features. PMID:24700674

Tysz, Beyhan; Bilguvar, Kaya; Koer, Naci; Yal?nkaya, Cengiz; a?layan, Okay; Gl, Ece; Sahin, Sezgin; omu, Sinan; Gnel, Murat

2014-07-01

364

Formulation and characterization of new layered diffusional matrices for zero-order sustained release  

Microsoft Academic Search

Statistical designs were used to study the effect of certain matrix formulation variables on the in vitro release of a model compound, pseudoephedrine hydrochloride, from layered diffusional matrices designed for zero-order sustained release. These matrices consist of non-swellable, hydrophobic middle layers containing the active drug to which hydrophilic and\\/or hydrophobic barrier layers are press-coated. In general, linear release profiles can

N Chidambaram; William Porter; Kolette Flood; Yihong Qiu

1998-01-01

365

COMMUNIQUE DE PRESSE / COMMUNIQUE DE PRESSE / COMMUNIQUE DE PRESSE Ecole Centrale Paris  

E-print Network

and Technology (South Korea) Pusan National University (South Korea) EcoleCentraleParis #12;COMMUNIQUE DE PRESSE) Japan Aerospace Exploration Agency (Japan) Korea Institute of Energy Research (South Korea and the Far East (Japan, Korea) closer in the field of research and its management with a special emphasis

Paragios, Nikos

366

CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis  

PubMed Central

Endoplasmic reticulum (ER) stress-mediated apoptosis is a key feature of hepatocyte cytotoxicity by saturated free fatty acids (FFA). This lipoapoptosis is dependent, in part, on the transcriptional upregulation of the BH3-only protein PUMA (p53 upregulated modulator of apoptosis). Although the activator protein (AP)-1 complex facilitates PUMA expression by saturated FFA, the transcription factor CAAT/enhancer binding homologous protein (CHOP) is also induced by ER stress and promotes apoptosis. To integrate the role of these two transcription factors in ER stress-induced apoptosis, we examined the relative contribution of CHOP and AP-1 in mediating PUMA induction by saturated FFA. Our results demonstrate that short-hairpin RNA-targeted knockdown of CHOP attenuates palmitate-induced apoptosis in Huh-7 cells. Loss of CHOP induction also reduced the increase in PUMA mRNA and protein levels as well as Bax activation by palmitate. No functional CHOP binding sites were identified in the PUMA promoter sequence. Rather, we observed that CHOP physically interacts with the AP-1 complex protein c-Jun upon palmitate treatment, and a CHOP:phosphorylated c-Jun heteromeric complex binds to the AP-1 consensus binding sequence within the PUMA promoter region. Finally, loss of function studies suggest that both transcription factors are necessary for maximal PUMA induction. Collectively, these data suggest that CHOP and AP-1 cooperatively mediate PUMA induction during hepatocyte lipoapoptosis. PMID:20430872

Cazanave, Sophie C.; Elmi, Nafisa A.; Akazawa, Yuko; Bronk, Steven F.; Mott, Justin L.

2010-01-01

367

Kinetic analysis and fragment screening with Fujifilm AP-3000.  

PubMed

We evaluated the performance of Fujifilm's new AP-3000 surface plasmon resonance biosensor for kinetic analysis and fragment screening. Using carbonic anhydrase II as a model system, we characterized a set of 10 sulfonamide-based inhibitors that range in molecular mass from 98 to 341Da and approximately 10,000-fold in affinity (0.4mM to 20nM). Although the data collected from the AP-3000 were generally similar to those collected using a Biacore T100, the AP-3000's stop-flow analyte delivery system complicated the shapes of the association- and dissociation-phase binding responses. We illustrate how reasonable estimates of the kinetic rate constants can be extracted from AP-3000 data by limiting data analysis to only the regions of the responses collected during flow conditions. We also provide an example of the results obtained for a fragment-screening study with the AP-3000, which is the ideal application of this technology. PMID:20371220

Rich, Rebecca L; Myszka, David G

2010-07-15

368

Characterization of Schistosome Tegumental Alkaline Phosphatase (SmAP)  

PubMed Central

Schistosomes are parasitic platyhelminths that currently infect over 200 million people globally. The parasites can live for years in a putatively hostile environment - the blood of vertebrates. We have hypothesized that the unusual schistosome tegument (outer-covering) plays a role in protecting parasites in the blood; by impeding host immunological signaling pathways we suggest that tegumental molecules help create an immunologically privileged environment for schistosomes. In this work, we clone and characterize a schistosome alkaline phosphatase (SmAP), a predicted ?60 kDa glycoprotein that has high sequence conservation with members of the alkaline phosphatase protein family. The SmAP gene is most highly expressed in intravascular parasite life stages. Using immunofluorescence and immuno-electron microscopy, we confirm that SmAP is expressed at the host/parasite interface and in internal tissues. The ability of living parasites to cleave exogenous adenosine monophosphate (AMP) and generate adenosine is very largely abolished when SmAP gene expression is suppressed following RNAi treatment targeting the gene. These results lend support to the hypothesis that schistosome surface enzymes such as SmAP could dampen host immune responses against the parasites by generating immunosuppressants such as adenosine to promote their survival. This notion does not rule out other potential functions for the adenosine generated e.g. in parasite nutrition. PMID:21483710

Bhardwaj, Rita; Skelly, Patrick J.

2011-01-01

369

Validation of the new trapped environment AE9/AP9/SPM at low Earth orbit  

NASA Astrophysics Data System (ADS)

The completion of the international space station (ISS) in 2011 has provided the space research community an ideal proving ground for future long duration human activities in space. Ionizing radiation measurements in ISS form the ideal tool for the validation of radiation environmental models, nuclear transport codes and nuclear reaction cross sections. Indeed, prior measurements on the space transportation system (STS; shuttle) provided vital information impacting both the environmental models and the nuclear transport code developments by indicating the need for an improved dynamic model of the low Earth orbit (LEO) trapped environment. Additional studies using thermo-luminescent detector (TLD), tissue equivalent proportional counter (TEPC) area monitors, and computer aided design (CAD) model of earlier ISS configurations, confirmed STS observations that, as input, computational dosimetry requires an environmental model with dynamic and directional (anisotropic) behavior, as well as an accurate six degree of freedom (DOF) definition of the vehicle attitude and orientation along the orbit of ISS. At LEO, a vehicle encounters exposure from trapped particles and attenuated galactic cosmic rays (GCR). Within the trapped field, a challenge arises from properly estimating the amount of exposure acquired. There exist a number of models to define the intensities of the trapped particles during the solar quiet and active times. At active times, solar energetic particles (SEP) generated by solar flare or coronal mass ejection (CME) also contribute to the exposure at high northern and southern latitudes. Among the more established trapped models are the historic and popular AE8/AP8, dating back to the 1980s, the historic and less popular CRRES electron/proton, dating back to 1990s and the recently released AE9/AP9/SPM. The AE9/AP9/SPM model is a major improvement over the older AE8/AP8 and CRRES models. This model is derived from numerous measurements acquired over four solar cycles dating back to the 1970s, roughly representing 40 years of data collection. In contrast, the older AE8/AP8 and CRRES models were limited to only a few months of measurements taken during the prior solar minima and maxima. The dual goal of this paper is to first validate the AE8/AP8 and AE9/AP9/SPM trapped models against ISS dosemetric measurements for a silicon based detector, to assess the improvements in the AE9/AP9/SPM model as compared to AE8/AP8 model. The validation is done at selected target points within ISS-6A configuration during its passage through the south Atlantic anomaly (SAA). For such validation, only the isotropic spectrum of either model is needed. As a second goal, the isotropic spectra of both trapped models are re-casted into anisotropic spectra by modulating them with a measurement derived angular formalism which is applicable to trapped protons. Since at LEO electrons have minimal exposure contribution, the paper ignores the AE8 and AE9 component of the models and presents the angular validation of AP8 and AP9 against measurements from the compact environment anomaly sensor (CEASE) science instrument package, flown onboard the tri-service experiment-5 (TSX-5) satellite during the period of June 2000-July 2006. The spin stabilized satellite was flown in a 410 1710 km, 69 inclination orbit, allowing it to be exposed to a broad range of LEO regime. Particular emphasize is put on the validation of proton flux profiles at differential 40 MeV and integral >40 MeV, in the vicinity of SAA where protons exhibit east-west (EW) anisotropy and have a relatively narrow pitch angle distribution. Within SAA, the EW anisotropy results in different level of exposure to each side of CEASE instrument package, allowing the extraction of anisotropic proton spectra from the measurements. While the magnitude of the EW effect at LEO depends on a multitude of factors such as trapped proton energy, orientation of the spacecraft along the velocity vector and altitude of the spacecraft, for this part, the paper draws quantitative conclusions on t

Badavi, Francis F.

2014-09-01

370

The Sybtraps: control of synaptobrevin traffic by synaptophysin, ?-synuclein and AP-180.  

PubMed

Synaptobrevin II (sybII) is a key fusogenic molecule on synaptic vesicles (SVs) therefore the active maintenance of both its conformation and location in sufficient numbers on this organelle is critical in both mediating and sustaining neurotransmitter release. Recently three proteins have been identified having key roles in the presentation, trafficking and retrieval of sybII during the fusion and endocytosis of SVs. The nerve terminal protein ?-synuclein catalyses sybII entry into SNARE complexes, whereas the monomeric adaptor protein AP-180 is required for sybII retrieval during SV endocytosis. Overarching these events is the tetraspan SV protein synaptophysin, which is a major sybII interaction partner on the SV. This review will evaluate recent studies to propose working models for the control of sybII traffic by synaptophysin and other Sybtraps (sybII trafficking partners) and suggest how dysfunction in sybII traffic may contribute to human disease. PMID:24279465

Gordon, Sarah L; Cousin, Michael A

2014-03-01

371

A comparison of impulse drying to double felted pressing on pilot- scale shoe presses and roll presses. Progress report, No. 6  

SciTech Connect

Pilot-scale shoe press and roll press experiments have been conducted to compare impulse drying and double felted pressing. Both ceramic coated and Beloit Type C press rolls have been evaluated. The experiments show that impulse drying can provide significantly higher outgoing solids than double felled pressing at the same impulse. For example, at an impulse of 0.234 MPa seconds (34 psi seconds), sheets at an ingoing solids of 52% were impulse dried (using the Beloit Type C press roll) to 68% solids while optimized double felled pressing could only yield press dryness of, at most, 60%.

Orloff, D.I.

1992-08-01

372

On the abundance of Europium. [in Ap and Am stars  

NASA Technical Reports Server (NTRS)

The inclusion of the effects of hyperfine splitting can significantly lower the abundance estimate of Eu from singly ionized lines which lie on the flat portion of the curve of growth. In the 21 cool Ap stars studied by Adelman and the five Am stars studied by Smith, the Eu abundance was reduced by 0.4 dex on the average. In individual cases, the reductions were as great as 0.9 dex. This makes the Eu abundance comparable to that of its neighboring rare earths Sm and Gd in the Ap stars and less than Sm and Gd in the Am stars, but still substantially overabundant with respect to solar values.

Hartoog, M. R.; Cowley, C. R.; Adelman, S. J.

1974-01-01

373

Piping benchmark problems for the Westinghouse AP600 Standardized Plant  

SciTech Connect

To satisfy the need for verification of the computer programs and modeling techniques that will be used to perform the final piping analyses for the Westinghouse AP600 Standardized Plant, three benchmark problems were developed. The problems are representative piping systems subjected to representative dynamic loads with solutions developed using the methods being proposed for analysis for the AP600 standard design. It will be required that the combined license licensees demonstrate that their solutions to these problems are in agreement with the benchmark problem set.

Bezler, P.; DeGrassi, G.; Braverman, J.; Wang, Y.K.

1997-01-01

374

ARTICLE IN PRESS Physica A ( )  

E-print Network

in packet generation rate Xiao-Gai Tang, Eric W.M. Wong Department of Electronic Engineering, City. E-mail addresses: tang-xg@hotmail.com (X.-G. Tang), ewong@ee.cityu.edu.hk (E.W.M. Wong). 0378 this article in press as: X.-G. Tang, E.W.M. Wong, Information traffic in scale-free networks with fluctuations

Wong, Eric Wing-Ming

375

Exploring Mars: the Ares Payload Service (APS)  

NASA Technical Reports Server (NTRS)

In last year's Mars Society convention we introduced the results of five years of studies of space launch capability for the second millennium. We concluded that Single Stage to Orbit (SSTO) vehicles such as the Delta Clipper X33, and X34 cannot make it to orbit from the Earth's surface. Whether taking off vertically or horizontally or landing vertically or horizontally, the rocket equations, the performance of available fuels, and the realities of the weight and strength of materials leave no margin for payload. The promised savings from SSTO systems are illusory. However, a configuration that is able to deliver useful payload to orbit is the Single step to Orbit, SsTO, a rocket plane that is released fully fueled, from 35,000 to 40,000 feet altitude. Three approaches have been proposed. The Hot'l and Molnya Corporation designs carry the fueled rocket plane to altitude on the back of a carrier aircraft. In this design the carrier aircraft is Russia's Antonov 225 the world's largest cargo plane. The rocket plane is a modified version of the Buran, Russia's own space shuttle. Another configuration is Kelly Aviation's concept in which the fully fueled rocket plane is towed to altitude by the cargo plane and then released. A third approach is based on the early "X" planes, which were dropped from the belly of the carrier plane. While the rocket equations indicate that these three concepts can deliver useful payloads, the Stanford review found significant advantages to the approach of Pioneer Rocket, in which the rocket plane flies up to the carrier plane with conventional jet engines, docks, and then loads on the oxidizer for the flight to orbit. This architecture has more reasonable abort modes in case of system failure in either aircraft and can deliver a larger final payload to orbit for a given sized carrier. The Stanford recommendation is that the carrier aircraft be the Antonov 225. A design based on this was presented in a report last year. Refinements to the design notably an improved re-entry cooling system and fueling stability analysis were done this year. More technical detail and a proposed international consortium to develop the SSTO is presented in another session of this year's Mars convention. We believe that there will be no human exploration of Mars based on the Shuttle or Expendable launch vehicles, and no resources available except for a cooperative international program. However, just as the world is learning to cooperate in peacekeeping, we hold out the hope that similar cooperation will develop for Mars exploration. With that in mind, this year we asked the question- "How will the human mission get to Mars if it has to use the SsTO for transportation?"

Bowen, Justin; Lusignan, Bruce

1999-01-01

376

Exploring Mars: The Ares Payload Service (APS)  

NASA Astrophysics Data System (ADS)

In last year's Mars Society convention we introduced the results of five years of studies of space launch capability for the second millennium. We concluded that Single Stage to Orbit (SSTO) vehicles such as the Delta Clipper X33, and X34 cannot make it to orbit from the Earth's surface. Whether taking off vertically or horizontally or landing vertically or horizontally, the rocket equations, the performance of available fuels, and the realities of the weight and strength of materials leave no margin for payload. The promised savings from SSTO systems are illusory. However, a configuration that is able to deliver useful payload to orbit is the Single step to Orbit, SsTO, a rocket plane that is released fully fueled, from 35,000 to 40,000 feet altitude. Three approaches have been proposed. The Hot'l and Molnya Corporation designs carry the fueled rocket plane to altitude on the back of a carrier aircraft. In this design the carrier aircraft is Russia's Antonov 225 the world's largest cargo plane. The rocket plane is a modified version of the Buran, Russia's own space shuttle. Another configuration is Kelly Aviation's concept in which the fully fueled rocket plane is towed to altitude by the cargo plane and then released. A third approach is based on the early "X" planes, which were dropped from the belly of the carrier plane. While the rocket equations indicate that these three concepts can deliver useful payloads, the Stanford review found significant advantages to the approach of Pioneer Rocket, in which the rocket plane flies up to the carrier plane with conventional jet engines, docks, and then loads on the oxidizer for the flight to orbit. This architecture has more reasonable abort modes in case of system failure in either aircraft and can deliver a larger final payload to orbit for a given sized carrier. The Stanford recommendation is that the carrier aircraft be the Antonov 225. A design based on this was presented in a report last year. Refinements to the design notably an improved re-entry cooling system and fueling stability analysis were done this year. More technical detail and a proposed international consortium to develop the SSTO is presented in another session of this year's Mars convention. We believe that there will be no human exploration of Mars based on the Shuttle or Expendable launch vehicles, and no resources available except for a cooperative international program. However, just as the world is learning to cooperate in peacekeeping, we hold out the hope that similar cooperation will develop for Mars exploration. With that in mind, this year we asked the question- "How will the human mission get to Mars if it has to use the SsTO for transportation?"

Bowen, Justin; Lusignan, Bruce

1999-08-01

377

The Dao of human cloning: utopian/dystopian hype in the British press and popular films.  

PubMed

The issue of human cloning has featured in the national science policy agendas in both the United States and the United Kingdom since the announcement in 1997 of Dolly the cloned sheep's birth in Scotland. Such news stories suggesting the imminent cloning of humans have inspired fictional entertainment media over the years, including numerous popular films. Study 1 examines elite British press coverage of human cloning from 1997 to 2004 (n = 857). Study 2 focuses on five human cloning films released between 1978 and 2003. Two sharply divergent discourses emerged from these data. Unqualified hope and habitually hyped claims of future cures permeated the press discourse. In contrast, the films constructed human cloning as an inherently dangerous technology often wielded by hubristic scientists in the tradition of Frankenstein. Both the predominately positive hype in the broadsheet press and the largely negative hype in the films indicate an impoverished and "thin" public debate on the issue of human cloning. PMID:19391375

Jensen, Eric

2008-04-01

378

Influence of excitatory amino acids on basal and sensory stimuli-induced release of 5-HT in the locus coeruleus  

PubMed Central

The interactions between 5-hydroxytryptaminergic neurones and excitatory amino acid utilizing neurones were studied in the locus coeruleus of conscious, freely moving rats. The locus coeruleus was superfused with artificial cerebrospinal fluid through a push-pull cannula and 5-hydroxytryptamine (5-HT) was determined in the superfusate that was continuously collected in time periods of 10?min. Superfusion of the locus coeruleus with the NMDA receptor antagonist AP5 (10??M), kynurenic acid (1?mM), or the AMPA/kainate receptor antagonist DNQX (10??M) reduced the 5-HT release in the locus coeruleus. Superfusion with the agonists NMDA (50??M), kainic acid (50??M) or AMPA (10??M) enhanced the release rate of 5-HT. AP5 (10??M) blocked the stimulant effect of NMDA, while tetrodotoxin (1??M) failed to influence the NMDA-induced release of 5-HT. In the presence of 10??M DNQX, the releasing effect of 50??M kainic acid was abolished. Pain elicited by tail pinch, as well as noise-induced stress, increased the release of 5-HT. Superfusion of the locus coeruleus with 10??M AP5 reduced the tail pinch-induced 5-HT release. AP5 (10??M) did not affect the noise-induced release of 5-HT which was reduced, when the locus coeruleus was superfused simultaneously with this concentration of AP5 and 1??M kynurenic acid. DNQX (10?mM) failed to influence the release of 5-HT induced by tail pinch or noise. The findings suggest that 5-hydroxytryptaminergic neurones of the locus coeruleus are tonically modulated by excitatory amino acids via NMDA and AMPA/kainate receptors. The release of 5-HT elicited by tail pinch and noise is mediated to a considerable extent through endogenous excitatory amino acids acting on NMDA receptors, while AMPA/kainate receptors are not involved in this process. PMID:9517395

Singewald, Nicolas; Kaehler, Stefan T; Hemeida, Ramadan; Philippu, Athineos

1998-01-01

379

The Relationship between AP[R] Exam Performance and College Outcomes. Research Report No. 2009-4  

ERIC Educational Resources Information Center

This study focused on the relationship between students' Advanced Placement Program[R] (AP[R]) performance in AP English Language, Biology, Calculus, and U.S. History, and their subsequent college success. For each AP Exam studied, students were divided into three groups according to their AP Exam performance (no AP Exam taken, score of 1 or 2,

Mattern, Krista D.; Shaw, Emily J.; Xiong, Xinhui

2009-01-01

380

NASA/MSFC Large Stretch Press Study  

NASA Technical Reports Server (NTRS)

The purpose of this study was to: A. assess and document the advantages/disadvantages of a government agency investment in a large stretch form press on the order of 5000 tons capacity (per jaw); B. develop a procurement specification for the press; and C. provide trade study data that will permit an optimum site location. Tasks were separated into four major elements: cost study, user survey, site selection, and press design/procurement specification.

Choate, M. W.; Nealson, W. P.; Jay, G. C.; Buss, W. D.

1985-01-01

381

Expanded Analysis of Hot Isostatic Pressed Iodine-Loaded Silver-Exchanged Mordenite  

SciTech Connect

Reduced silver-exchanged mordenite (Ag0Z) is being evaluated as a potential material to control the release of radioactive iodine that is released during the reprocessing of used nuclear fuel into the plant off-gas streams. The purpose of this study was to determine if hot pressing could directly convert this iodine loaded sorbent into a waste form suitable for long-term disposition. The minimal pretreatment required for production of pressed pellets makes hot pressing a technically and economically desirable process. Initial scoping studies utilized hot uniaxial pressing (HUPing) to prepare samples of non-iodine-loaded reduced silver exchanged mordenite (Ag0Z). The resulting samples were very fragile due to the low pressure (~ 28 MPa) used. It was recommended that hot isostatic pressing (HIPing), performed at higher temperatures and pressures, be investigated. HIPing was carried out in two phases, with a third and final phase currently underway. Phase I evaluated the effects of pressure and temperature conditions on the manufacture of a pressed sample. The base material was an engineered form of silver zeolite. Six samples of Ag0Z and two samples of I-Ag0Z were pressed. It was found that HIPing produced a pressed pellet of high density. Analysis of each pressed pellet by scanning electron microscopy-energy dispersive spectrophotometry (SEM-EDS) and X-ray diffraction (XRD) demonstrated that under the conditions used for pressing, the majority of the material transforms into an amorphous structure. The only crystalline phase observed in the pressed Ag0Z material was SiO2. For the samples loaded with iodine (I-Ag0Z) iodine was present as AgI clusters at low temperatures, and transformed into AgIO4 at high temperatures. Surface mapping and EDS demonstrate segregation between silver iodide phases and silicon dioxide phases. Based on the results of the Phase I study, an expanded test matrix was developed to examine the effects of multiple source materials, compositional variations, and an expanded temperature range. Each sample was analyzed with the approach used in Phase I. In all cases, there is nothing in the SEM or XRD analyses that indicates creation of any AgI-containing silicon phase, with the samples being found to be largely amorphous. Phase III of this study has been initiated and is the final phase of scoping tests. It will expand upon the test matrix completed in Phase II and will examine the durability of the pressed pellets through product consistency testing (PCT) studies. Transformation of the component material into a well-characterized iodine-containing mineral phase would be desirable. This would limit the additional experimental testing and modeling required to determine the long-term stability of the pressed pellet, as much of that information has already been learned for several common iodine-containing minerals. However, this is not an absolute requirement, especially if pellets produced by hot isostatic pressing can be demonstrated through initial PCT studies to retain iodine well despite their amorphous composition.

Jubin, R. T. [ORNL; Bruffey, S. H. [ORNL; Patton, K. K. [ORNL

2014-09-30

382

Freedom House: Press Freedom Survey 2000  

NSDL National Science Digital Library

Published by Freedom House, a non-partisan advocacy organization for democracy and human rights worldwide founded by Eleanor Roosevelt, Wendell Willkie, and others, the 2000 edition of the Press Freedom Survey offers a "country-by-country worldwide assessment of press freedom." This year's study, which examines freedom of the press in 186 countries, pays special attention to government restrictions on Internet access. It finds that "nearly two-thirds of countries, accounting for 80 percent of the world's population, restrict press freedom." Users can download the full text of the 36-page report in .pdf format or view the country reports, methodology, and tables and charts in HTML format.

383

APS Forum on Education Newsletter - Summer 2010 Edition  

NSDL National Science Digital Library

In the Teacher Preparation Section of this edition, Gay Stewart talks about the Arkansas Noyce Scholarship Program and Gabe Popkin discusses the PhysTEC Noyce. Other articles include an introduction to the APS Minority Bridge Program and an outline of some student opportunities available through the Center for Excellence in Education.

2010-07-06

384

Fabrication of the APS Storage Ring radio frequency accelerating cavities  

SciTech Connect

Specification, heat treatment, strength, and fatigue life of the Advanced Photon Source (APS) Storage Ring 352-MHz radio frequency (RF) accelerating cavity copper is discussed. Heat transfer studies, including finite element analysis, and configuration of water cooling is described. Requirements for and techniques of machining are considered. Braze and electron beam joint designs are compared. Vacuum considerations during fabrication are discussed.

Primdahl, K.; Bridges, J.; DePaola, F.; Kustom, R. [Argonne National Lab., IL (US); Snee, D. [Fermi National Accelerator Lab., Batavia, IL (US)

1993-07-01

385

Nuclear Reactor Safety--The APS Submits its Report  

ERIC Educational Resources Information Center

Presents the summary section of the American Physical Society (APS) report on the safety features of the light-water reactor, reviews the design, construction, and operation of a reactor and outlines the primary engineered safety features. Summarizes the major recommendations of the study group. (GS)

Physics Today, 1975

1975-01-01

386

APS/NIDDK Minority Travel Fellowship Awards Program  

NSDL National Science Digital Library

This article is on page 48 of The Physiologist, April 2012. Since its inception in 1987, the APS/NIDDK Minority Travel Fellowship Program has awarded more than 810 travel fellowships to over 555 undergraduate, graduate, and postdoctoral students and to faculty members at minority institutions.

APS Education Office (American Physiological Society Education Office)

2012-04-01

387

84th President of APS Joey P. Granger  

NSDL National Science Digital Library

This article is on pages 41 and 45-49 of the PDF file. An article in The Physiologist April 2011 introducing Joey P. Granger and outlining what he views as the areas of strength in the APS and areas where improvment is needed.

PhD Joey P. Granger (University of Mississippi Medical Center Department of Physiology)

2011-04-01

388

AP: A Critical Examination of the Advanced Placement Program  

ERIC Educational Resources Information Center

With an annual yearly growth rate of 9.3 percent over the last two decades, Advanced Placement courses have become a juggernaut in American high school education. AP courses are routinely perceived as an indicator of educational rigor, and many schools push to enroll low-income or minority students in these courses in the hope of preparing them

Sadler, Philip M., Ed.; Sonnert, Gerhard, Ed.; Tai, Robert H., Ed.; Klopfenstein, Kristin, Ed.

2010-01-01

389

Vibrational Mechanics: Nonlinear Dynamic Effects, General Ap-proach, Applications  

E-print Network

Review of: Vibrational Mechanics: Nonlinear Dynamic Effects, General Ap- proach, Applications Iliya.H.M. van der Heijden, University College London, UK Fast vibrations may have strong and sometimes pendulum by rapid oscillation of its point of support, the shift of a vibrating compass needle and the self

van der Heijden, Gert

390

APS/123-QED Electrowetting with Contact Line Pinning  

E-print Network

on the micro-scale1­15 . By ap- plying electric fields via actuating electrodes (see Figure 1), surface tension that are used to shape, move, split, merge, and mix fluids in micro-scale devices. Applications pixels for laptops and video-speed smart paper3,9,10 . This paper is concerned with modeling and simu

Nochetto, Ricardo H.

391

APS storage ring vacuum chamber: Section 1, Evaluation  

SciTech Connect

The vacuum characteristics of the APS storage ring vacuum chamber prototype, Section One (S1), is presented. The base pressure achieved was 4 {times} 10{sup {minus}11}, the welds contained no virtual or real leaks, the NeG strip mounting design and activation procedures have been determined, and S1 was found contaminated with hydrocarbons.

Benaroya, R.; Roop, B.

1995-07-01

392

Mechanistic studies of the ClpAP protease/  

E-print Network

CIpA, a member of the Hspl00/Clp subset of the AAA+ superfamily, is an energy-dependent chaperone, disassembling and remodeling its protein substrates. CIpA also serves as the ATPase component of the ClpAP protease, where ...

Farbman, Mary E

2008-01-01

393

AP Biology Workshop: The Importance of Laboratory Work  

NSDL National Science Digital Library

This is a collection of essays that highlights the benefits of conducting lab experiments as part of the AP Biology curriculum. It encourages teachers to continue using learning tools like technology in lab experiments to enhance the classroom experience for students.

The College Board The College Board (The College Board; )

2012-10-24

394

APS/123-QED Dust Successive Generations in Complex Plasmas  

E-print Network

APS/123-QED Dust Successive Generations in Complex Plasmas: A Cyclic Phenomenon in the Void Region´eans cedex 2, France (Dated: December 5, 2007) Dust formation and growth in plasmas are in most cases continuous cyclic phenomena. We show that the growth of new dust generations takes place in a dust free

Boyer, Edmond

395

The Nexus of Energy & Water APS, Berkeley, CA  

E-print Network

.D. Energy and Water 11 March 5, 2011 There Are Four Main Points to Remember 1. Energy and water There Are Two Main Cooling Approaches Open-Loop Cooling Closed-Loop Cooling Most water that is withdrawnThe Nexus of Energy & Water APS, Berkeley, CA Michael E. Webber, Ph.D. March 5, 2011 #12;Michael E

Kammen, Daniel M.

396

The accretion of interplanetary dust by Ap and Am stars  

NASA Technical Reports Server (NTRS)

Accretion of interplanetary dust and comets by A-type stars is investigated to see whether this process can explain the overabundances of heavy elements in Ap and Am stars. The dust particles spiral in by the Poynting-Robertson effect and evaporate above the star. This process is evaluated by considering the evolution of silicate and graphite particles in the radiation field of Alpha Leo (B7 V). It is found that graphite particles evaporate above 20 stellar radii and silicate dust grains above 50 stellar radii. The evaporated atoms will be quickly ionized. In the case of Am stars the ions will wander off and not reach the photosphere, but in the case of Ap stars they can be trapped by the magnetic field of the star and reach the surface. The magnetosphere of a typical Ap star is modeled, and the fate of the ions is studied. The efficiency of accretion from the magnetosphere is sensitive to the presence of any plasma in the magnetosphere. The comet impact process is found capable of producing the abundance anomalies in Ap as well as Am stars, assuming that the comet impact rate is 0.03/yr, nearly the same as in the solar system.

Kumar, C. Krishna; Davila, Joseph M.; Rajan, R. Sundar

1989-01-01

397

ACTIVATION OF AP-1 IN UROTSA CELLS BY METHYLATED ARSENICALS  

EPA Science Inventory

ACTIVATION OF AP-1 IN UROTSA CELLS BY METHYLATED TRIVALENT ARSENICALS. Z Drobna1, I Jaspers2, D J Thomas3 and M Styblo1. 1Department of Pediatrics; 2Center for Environmental Medicine and Lung Biology, University of North Carolina at Chapel Hill, NC, USA; 3US EPA, RTP, NC, USA....

398

Effect of enzyme-aided cell wall disintegration on protein extractability from intact and dehulled rapeseed (Brassica rapa L. and Brassica napus L.) press cakes.  

PubMed

Cell-wall- and pectin-degrading enzyme preparations were used to enhance extractability of proteins from rapeseed press cake. Rapeseed press cakes from cold pressing of intact Brassica rapa and partially dehulled Brassica napus seeds, containing 36-40% protein and 35% carbohydrates, were treated with pectinolytic (Pectinex Ultra SP-L), xylanolytic (Depol 740L), and cellulolytic (Celluclast 1.5L) enzyme preparations. Pectinex caused effective disintegration of embryonic cell walls through hydrolysis of pectic polysaccharides and glucans and increased protein extraction by up to 1.7-fold in comparison to treatment without enzyme addition. Accordingly, 56% and 74% of the total protein in the intact and dehulled press cakes was extracted. Light microscopy of the press cakes suggested the presence of pectins colocalized with proteins inside the embryo cells. Hydrolysis of these intracellular pectins and deconstruction of embryonic cell walls during Pectinex treatment were concluded to relate with enhanced protein release. PMID:25039585

Rommi, Katariina; Hakala, Terhi K; Holopainen, Ulla; Nordlund, Emilia; Poutanen, Kaisa; Lantto, Raija

2014-08-13

399

Clathrin functions in the absence of heterotetrameric adaptors and AP180-related proteins in yeast.  

PubMed Central

The major coat proteins of clathrin-coated vesicles are the clathrin triskelion and heterotetrameric associated protein (AP) complexes. The APs are thought to be involved in cargo capture and recruitment of clathrin to the membrane during endocytosis and sorting in the trans-Golgi network/endosomal system. AP180 is an abundant coat protein in brain clathrin-coated vesicles, and it has potent clathrin assembly activity. In Saccharomyces cerevisiae, there are 13 genes encoding homologs of heterotetrameric AP subunits and two genes encoding AP180-related proteins. To test the model that clathrin function is dependent on the heterotetrameric APs and/or AP180 homologs, yeast strains containing multiple disruptions in AP subunit genes, as well as in the two YAP180 genes, were constructed. Surprisingly, the AP deletion strains did not display the phenotypes associated with clathrin deficiency, including slowed growth and endocytosis, defective late Golgi protein retention and impaired cytosol to vacuole/autophagy function. Clathrin-coated vesicles isolated from multiple AP deletion mutants were morphologically indistinguishable from those from wild-type cells. These results indicate that clathrin function and recruitment onto membranes are not dependent upon heterotetrameric adaptors or AP180 homologs in yeast. Therefore, alternative mechanisms for clathrin assembly and coated vesicle formation, as well as the role of AP complexes and AP180-related proteins in these processes, must be considered. PMID:10406795

Huang, K M; D'Hondt, K; Riezman, H; Lemmon, S K

1999-01-01

400

AP4 is required for mitogen- and c-MYC-induced cell cycle progression  

PubMed Central

AP4 represents a c-MYC-inducible bHLH-LZ transcription factor, which displays elevated expression in many types of tumors. We found that serum-starved AP4-deficient mouse embryo fibroblasts (MEFs) were unable to resume proliferation and showed a delayed S-phase entry after restimulation. Furthermore, they accumulated as tetraploid cells due to a cytokinesis defect. In addition, AP4 was required for c-MYC-induced cell cycle re-entry. AP4-deficient MEFs displayed decreased expression of CDK2 (cyclin-dependent kinase 2), which we characterized as a conserved and direct AP4 target. Activation of an AP4 estrogen receptor fusion protein (AP4-ER) enhanced proliferation of human diploid fibroblasts in a CDK2-dependent manner. However, in contrast to c-MYC-ER, AP4-ER activation was not sufficient to induce cell cycle re-entry or apoptosis in serum-starved MEFs. AP4-deficiency was accompanied by increased spontaneous and c-MYC-induced DNA damage in MEFs. Furthermore, c-MYC-induced apoptosis was decreased in AP4-deficient MEFs, suggesting that induction of apoptosis by c-MYC is linked to its ability to activate AP4 and thereby cell cycle progression. Taken together, these results indicate that AP4 is a central mediator and coordinator of cell cycle progression in response to mitogenic signals and c-MYC activation. Therefore, inhibition of AP4 function may represent a therapeutic approach to block tumor cell proliferation. PMID:25261373

Jackstadt, Rene; Hermeking, Heiko

2014-01-01

401

AP4 is required for mitogen- and c-MYC-induced cell cycle progression.  

PubMed

AP4 represents a c-MYC-inducible bHLH-LZ transcription factor, which displays elevated expression in many types of tumors. We found that serum-starved AP4-deficient mouse embryo fibroblasts (MEFs) were unable to resume proliferation and showed a delayed S-phase entry after restimulation. Furthermore, they accumulated as tetraploid cells due to a cytokinesis defect. In addition, AP4 was required for c-MYC-induced cell cycle re-entry. AP4-deficient MEFs displayed decreased expression of CDK2 (cyclin-dependent kinase 2), which we characterized as a conserved and direct AP4 target. Activation of an AP4 estrogen receptor fusion protein (AP4-ER) enhanced proliferation of human diploid fibroblasts in a CDK2-dependent manner. However, in contrast to c-MYC-ER, AP4-ER activation was not sufficient to induce cell cycle re-entry or apoptosis in serum-starved MEFs. AP4-deficiency was accompanied by increased spontaneous and c-MYC-induced DNA damage in MEFs. Furthermore, c-MYC-induced apoptosis was decreased in AP4-deficient MEFs, suggesting that induction of apoptosis by c-MYC is linked to its ability to activate AP4 and thereby cell cycle progression. Taken together, these results indicate that AP4 is a central mediator and coordinator of cell cycle progression in response to mitogenic signals and c-MYC activation. Therefore, inhibition of AP4 function may represent a therapeutic approach to block tumor cell proliferation. PMID:25261373

Jackstadt, Rene; Hermeking, Heiko

2014-09-15

402

AP Theory IV: Intrinsic Topological Quantum Langlands Theory  

E-print Network

Without using any moduli, sheaves, stacks, nor any analytic, nor category-type arguments, we exhibit an analogue to Geometric Langlands Theory in an entirely model-independent, non-perturbative,purely smooth topological context in Artin Presentation Theory. A basic initial feature is that AP Theory, as a whole, is already, ab initio, a universal canonical 2D sigma-model, targeting smooth, compact, simply-connected 4-manifolds with a connected boundary, and its topological Planckian quantum starting point, as well as its cone-like, infinitely-generated at each stage, graded group of homology-preserving, but topology-changing transitions/interactions, exhibit the most general qualitative S-duality. We first point out the numerous mathematically rigorous, model-free, (i.e., intrinsic), topological AP analogues with the heuristic Kapustin-Witten version of Geometric Langlands theory, as well as the crucial differences between the two theories. The latter have to exist since AP Theory deals, a priori, essentially only with discrete group-theoretic presentation theory, not Lie group representation theory, not with category nor moduli theory, does not need classical SUSY, nor Feynman integrals, lattice models, etc., and furthermore is model-independent and characteristic of real dimension four. It will become clear that AP Langlands theory is a model-independent, cone-like, graded, compact completion and topological 'envelope' of 4D N=4 SUSY YM theory, their starting point, anchored, kept in place, so to speak, by a purely discrete group-theoretic analogue of Donaldson/Seiberg-Witten theory. Due to its discrete group-theoretic conceptual simplicity and universality, the AP Langlands program should also be considered to be a new type of intrinsic model-free symmetry, a universal Erlanger Program for Modern Physics.

H. E. Winkelnkemper

2010-10-25

403

Defects in T-tubular electrical activity underlie local alterations of calcium release in heart failure  

PubMed Central

Action potentials (APs), via the transverse axial tubular system (TATS), synchronously trigger uniform Ca2+ release throughout the cardiomyocyte. In heart failure (HF), TATS structural remodeling occurs, leading to asynchronous Ca2+ release across the myocyte and contributing to contractile dysfunction. In cardiomyocytes from failing rat hearts, we previously documented the presence of TATS elements which failed to propagate AP and displayed spontaneous electrical activity; the consequence for Ca2+ release remained, however, unsolved. Here, we develop an imaging method to simultaneously assess TATS electrical activity and local Ca2+ release. In HF cardiomyocytes, sites where T-tubules fail to conduct AP show a slower and reduced local Ca2+ transient compared with regions with electrically coupled elements. It is concluded that TATS electrical remodeling is a major determinant of altered kinetics, amplitude, and homogeneity of Ca2+ release in HF. Moreover, spontaneous depolarization events occurring in failing T-tubules can trigger local Ca2+ release, resulting in Ca2+ sparks. The occurrence of tubule-driven depolarizations and Ca2+ sparks may contribute to the arrhythmic burden in heart failure. PMID:25288764

Crocini, Claudia; Coppini, Raffaele; Ferrantini, Cecilia; Yan, Ping; Loew, Leslie M.; Tesi, Chiara; Cerbai, Elisabetta; Poggesi, Corrado; Pavone, Francesco S.; Sacconi, Leonardo

2014-01-01

404

Aviation Safety Program: Weather Accident Prevention (WxAP) Development of WxAP System Architecture And Concepts of Operation  

NASA Technical Reports Server (NTRS)

This paper presents viewgraphs on the development of the Weather Accident Prevention (WxAP) System architecture and Concept of Operation (CONOPS) activities. The topics include: 1) Background Information on System Architecture/CONOPS Activity; 2) Activity Work in Progress; and 3) Anticipated By-Products.

Grantier, David

2003-01-01

405

Californium: Scalable Cloud Services for the Internet of Things through CoAP  

E-print Network

Californium: Scalable Cloud Services for the Internet of Things through CoAP Matthias Kovatsch protocol in cloud environments. Our Californium (Cf) CoAP framework shows 33 to 64 times higher throughput

406

The Adolescent Novel in AP English: A Response to Patricia Spencer.  

ERIC Educational Resources Information Center

Discusses the absence of adolescent literature in Advanced Placement (AP) English classes. Describes how a class of AP students and their teacher benefited from reading Robert Cormier's "The Chocolate War." (PRA)

McGee, Tim

1992-01-01

407

Synaptic and genomic responses to JNK and AP-1 signaling in Drosophilaneurons  

E-print Network

Background: The transcription factor AP-1 positively controls synaptic plasticity at the Drosophila neuromuscular junction. Although in motor neurons, JNK has been shown to activate AP-1, a positive regulator of growth and ...

Narayanan, Radhakrishnan

408

TheJournalofCellBiology The Rockefeller University Press, 0021-9525/2003/01/213/10 $8.00  

E-print Network

into four subunit polymeric adaptor protein complexes (APs;* AP1, AP2, AP3, and AP4; Hirst and Robinson two large homologous subunits ( 1 in the AP1 complex, 2 in the AP2 complex, and 3 in the AP3 complex

McMahon, Harvey

409

Toxics Release Inventory data currently available to the general public  

SciTech Connect

Toxics Release Inventory (TRI) reporting requirements mandate that covered industries report annually to the US Environmental Protection Agency (EPA) releases of some 650 substances. Releases include actual releases, transfers, and waste generated. Weights of releases of the specific substances to all media are reported, provided the facilities exceed certain thresholds for the substances. The combined weight of all releases is often reported in the press, regardless of the mode of release, likelihood of exposure, or toxicity. EPA, local agencies, environmental groups, and others analyze and combine the data using statistical techniques, and present the data at state-level, by geographical regions, by industry sector, and in other combinations. Recent regulatory action expanded the list of covered industries, and will cause the total reported releases to increase significantly, even though actual emissions by the reporting sources may in fact have decreased. As the TRI data are made available to the general public, EPA, the states, and the newly reporting industries will communicate with the public the significance of the new reported quantities. In preparation for these communication programs, reporting industries need to be cognizant of existing communication sources and vehicles. In an earlier time, government and corporate direct communications and press coverage constituted the majority of information flow. Today, many data sources are available on the Internet to anyone who is interested. Communication plans to discuss TRI releases need to consider the types of information already available to the average citizen. This paper describes some of the data and interpretive information currently available to the public and examines the type of data which is likely to become available in the near future.

Jensen, B.K.; Jensen, R.A.

1999-07-01

410

In response to a lawsuit filed by the Associated Press, artist Shepard Fairey countersues  

NSDL National Science Digital Library

Artist Files Lawsuit Against the Associated Press Over Image of Obamahttp://www.nytimes.com/2009/02/10/arts/design/10fair.htmlFair Use Project Files Suit Against The Associated Press on Behalf of Artist Shepard Fairey [pdf]http://cyberlaw.stanford.edu/node/6061Artist questions police's timing of his arrest on graffiti chargeshttp://www.boston.com/ae/theater_arts/articles/2009/02/10/cultural_acclaim_residents_anger/Lawrence Lessig: Remixhttp://fora.tv/2009/01/14/Lawrence_Lessig_Remix#chapter_01Banned in Bostonhttp://www.bu.edu/library/guides/boston/banned.htmlObey Giant [Macromedia Flash Player]http://obeygiant.com/Last Friday, contemporary artist Shepard Fairey was in Boston to celebrate the opening of his new gallery show at the Institute of Contemporary Art. He was probably not expecting to get arrested by the Boston Police Department, but that was exactly what happened on his way to the Institute's home in the Fort Point Channel neighborhood. Fairey was arrested on graffiti-related charges, and he later pled not guilty. It was the end of a busy week for Fairey, as The Associated Press sued him on Thursday for copyright infringement. The Associated Press (AP) has made the claim that he appropriated a 2006 AP photograph taken by Mannie Garcia for his iconic "Hope" poster, which became a popular image during President Barack Obama's campaign for president. This Monday, Fairey countersued the Associated Press, asking a judge to declare that he is in fact protected from copyright infringement claims as regards his use of the photo in question. The whole situation gets a bit more complicated as Garcia has recently stated he holds the copyright for the photograph. It remains to be seen how things will turn out for all the parties involved, but in a recent interview Garcia remarked, "I don't condone people taking things, just because they can, off the Internet. But in this case I think it's a very unique question."The first link will take readers to an article from this Tuesday's New York Times which talks about Fairey's current situation and the countersuit he recently filed against the AP. The second link leads to the text of the suit filed against the AP in support of Fairey's case by the Fair Use Project at Stanford University's Center for Internet and Society. The third link will take users to an article from this Tuesday's Boston Globe. The article takes a look at both Fairey's arrest and the reaction of Boston residents to his art. Moving on, the fourth link leads to a talk by Professor Lawrence Lessig on how copyright law might be transformed and modified for the 21st century. The fifth link leads to a delightful list from the Boston University Libraries about things that have been "banned in Boston" during the past several centuries. While Fairey's work wasn't banned per se, many other things have not been so lucky, including plays, pamphlets, and books like Theodore Dreiser's "An American Tragedy". The final link will take users to Fairey's own homepage, where they can view some of his works and learn more about his background.

Grinnell, Max

2009-02-13

411

Fracture toughness of hot-pressed beryllium  

NASA Technical Reports Server (NTRS)

This paper presents the results of an investigation into the fracture toughness, sustained-load flaw growth, and fatigue-crack propagation resistance of S200E hot-pressed beryllium at room temperature. It also reviews the literature pertaining to the influence of various factors on the fracture toughness of hot-pressed beryllium determined using fatigue-cracked specimens.

Lemon, D. D.; Brown, W. F., Jr.

1985-01-01

412

Consumer Satisfaction with Durable-Press Shirts.  

E-print Network

-.....-.------------------------ 6 Shirt Appearance .---..-.--~~----------------- 8 Shirt Preference by Consumers ---..-------------- 8 Commercially Laundered Shirts ---.----.--.------- 8 Results of Physical Tests ...................................... 8 A Permeability 8... Summary Little is known of consumer satisfaction with durable-press garments worn and laundered under typical circumstances. Because more than 90 percent of men's dre~s shirts are produced with a durable-press finish, they were selected...

Stover, Mary Sue

1972-01-01

413

Corruption as Portrayed by the Press  

Microsoft Academic Search

In exposing corruption, the Polish press tries to create a scandal, often without fulfilling the necessary conditions for transforming revelations into scandal. The press discusses the economic consequences of corruption but seldom pays attention to the ethical aspect of the problem. When it proposes remedies, these also belong to the arsenal of economic measures (\\

MA?GORZATA FUSZARA

1999-01-01

414

2013 Catalogue About ANU E Press  

E-print Network

and Print-on-Demand (PoD) texts. Electronic publishing also has incredible advantages for readers. Ebooks: > allow wide dissemination of information at very low cost (a student or researcher can download or read. How do I get E Press books? All ANU E Press titles are available for free download at epress

Botea, Adi

415

Evaluating the aluminum content of pressed dross  

NASA Astrophysics Data System (ADS)

Pressing of skimmed hot drosses in a press is a very popular technology for cooling hot dross and obtaining the maximum in-house recovery of aluminum alloy. As a result of the pressing action, part of the molten aluminum alloy is squeezed out, while the rest of the free metal remains in the pressed skulls. Thus, pressed skulls are a valuable waste product, consisting of 30 70 wt.% free aluminum. Other constituents are aluminum oxide and oxides of alloying metals. Pressed skulls are generally valued on a free-metal recovery basis, which necessarily involves practical determination of their free aluminum content. Because most analytical methods are limited to the laboratory level and representative sub-samples, there is a practical interest in developing a routine, cost-effective, and non-destructive method to predict the free aluminum content in entire pressed skulls, based on their density. To develop such a method, a relation between the bulk density, porosity, and free aluminum content of pressed skulls was established. This article offers a review of those experiments and an analysis of their results.

Kevorkijan, V.

2002-02-01

416

AP3: Cooperative, decentralized anonymous communication Alan Mislove Gaurav Oberoi Ansley Post Charles Reis Peter Druschel  

E-print Network

AP3: Cooperative, decentralized anonymous communication Alan Mislove Gaurav Oberoi Ansley Post communication services for participat- ing users. The Anonymizing Peer-to-Peer Proxy (AP3) sys- tem provides pseudonyms. AP3 is designed to be lightweight, low-cost and provides "probable innocence" anonymity

417

77 FR 35308 - Proposed Amendment of Restricted Area R-6601; Fort A.P. Hill, VA  

Federal Register 2010, 2011, 2012, 2013

...Amendment of Restricted Area R-6601; Fort A.P. Hill, VA AGENCY: Federal Aviation Administration...designation of restricted area R-6601, Fort A.P. Hill, VA. The U. S. Army requested...Banks, U.S. Army Garrison, Fort A.P. Hill, VA 22427; telephone: (804)...

2012-06-13

418

78 FR 21817 - Amendment of Restricted Area R-6601; Fort A.P. Hill, VA  

Federal Register 2010, 2011, 2012, 2013

...Amendment of Restricted Area R-6601; Fort A.P. Hill, VA AGENCY: Federal Aviation Administration...designation of restricted area R-6601, Fort A.P. Hill, VA. The U.S. Army requested...designation of restricted area R-6601, Fort A.P. Hill, VA, (77 FR 35308, June 13,...

2013-04-12

419

AP Studio Art as an Enabling Constraint for Secondary Art Education  

ERIC Educational Resources Information Center

Advanced Placement (AP) Studio Art is an influential force in secondary art education as is evident in the 31,800 portfolios submitted for review in 2008. From the perspectives of a high school educator and AP Reader, this author has observed how the constraints of the AP program can be used to generate support for high school art programs and

Graham, Mark A.

2009-01-01

420

APS: 125 Years of Progress of Physiology as a Scientific Discipline and a Profession  

ERIC Educational Resources Information Center

The Experimental Biology 2012 meeting in San Diego, CA, included events to celebrate the 125th anniversary of the founding of the American Physiological Society (APS) and reflect on the recent accomplishments of the society. Most of the APS activities in the past quarter century were guided by a series of strategic plans. Membership in the APS

Carroll, Robert G.; Frank, Martin; Ra'anan, Alice; Matyas, Marsha L.

2013-01-01

421

A remark on Ap'ery's numbers JeanPaul Allouche  

E-print Network

A remark on Ap'ery's numbers Jean­Paul Allouche CNRS, LRI B??atiment 490, F­91405 Orsay Cedex France allouche@lri.fr Abstract The Ap'ery numbers, introduced in Ap'ery's celebrated proof of the irrationality mod p. In a paper appeared in this journal (64 (1995), 11--19), C. Radoux asserted that the same

Allouche, Jean-Paul

422

ENGINEERING+AMINOR HOW TO PURSUE A MINOR AP/IB CREDIT SUMMER SEMESTERS  

E-print Network

14 ENGINEERING+AMINOR HOW TO PURSUE A MINOR · AP/IB CREDIT · SUMMER SEMESTERS DOUBLE COUNTING, as long as they plan ahead and map out a clear objective with the help of an advisor. AP/IB CREDIT courses that can be replaced with AP/IB credit include math, chemistry, biol- ogy and even a General

Rohs, Remo

423

AP STAR AWARDS Who is the shining star in your department?  

E-print Network

AP STAR AWARDS Who is the shining star in your department? Give them the honor they deserve! Deadline for application is February 4, 2011 The AP Stars award was created to express appreciation professionals on campus? Previous AP Stars recipients are not eligible to win again for two (2) years after

424

[Effect of diadenosine oligophosphates (Ap4A and Ap3A) and their phosphonate analogs on catalytic properties of phenylalanyl-tRNA synthetase from E. coli].  

PubMed

The influence of P1,P3-bis(5'-adenosyl)triphosphate (Ap3A), P1,P4-bis(5'-adenosyl)tetraphosphate (Ap4A) and its analogues, containing a residue of methylenediphosphonic acid in various positions of the oligophosphate chain, on the reactions catalysed by phenylalanyl-tRNA synthetase from E. coli MRE-600 has been studied. The compounds do not affect significantly the rate of ATP-[32P]PPi-exchange nor maintain this reaction in the absence of ATP. The diadenosineoligophosphates are shown to be noncompetitive inhibitors of ATP in the tRNA aminoacylation by phenylalanine (for Ap4A Ki = 1,45.10(-3) M). The phosphonate analogues of Ap4A inhibit the synthesis of Ap3A depending on their structure. The conclusion is thus drawn that the E. coli MRE-600 phenylalanyl-tRNA synthetase does not interact property with Ap4A and its phosphonate analogues. PMID:3322289

Biriukov, A P; Zakharova, O D; Lavrik, O I

1987-09-01

425

Diadenosine polyphosphates (Ap3A and Ap4A) behave as alarmones triggering the synthesis of enzymes of the phenylpropanoid pathway in Arabidopsis thaliana  

PubMed Central

It is known that cells under stress accumulate various dinucleoside polyphosphates, compounds suggested to function as alarmones. In plants, the phenylpropanoid pathways yield metabolites protecting these organisms against various types of stress. Observations reported in this communication link these two phenomena and provide an example of a metabolic addressee for an alarm signaled by diadenosine triphosphate (Ap3A) or diadenosine tetraphosphate (Ap4A). In response to added Ap3A or Ap4A, seedlings of Arabidopsis thaliana incubated in full nutrition medium increased both the expression of the genes for and the specific activity of phenylalanine ammonia-lyase and 4-coumarate:coenzyme A ligase, enzymes that control the beginning of the phenylpropanoid pathway. Neither adenine mononucleotides (AMP, ADP or ATP) nor adenosine evoked such effects. Reactions catalyzed in vitro by these enzymes were not affected by Ap3A or Ap4A. PMID:23650569

Pietrowska-Borek, Ma?gorzata; Nuc, Katarzyna; Zielezi?ska, Ma?gorzata; Guranowski, Andrzej

2011-01-01

426

UW Madison Libraries: Parallel Press  

NSDL National Science Digital Library

UW-Madison Libraries' Parallel Press combines book publishing traditions with new technology to provide print-on-demand books and a series of chapbooks (small, inexpensive books featuring the works of authors and poets with a Wisconsin connection). Print-on-demand books parallel the online editions created by the Libraries' digitizing initiatives. Currently, four titles, including David Hayman's A First-Draft Version of Finnegan's Wake (originally published in 1963) and The Book of Beasts (1954), by T.H. White, are available via Parallel Press print-on-demand service. The poetry chapbook series began in 1999 with the publication of four Wisconsin poets (Elizabeth Oness, Max Garland, Katharine Whitcomb, and Andrea Potos) and has continued with six chapbooks per year. A prose chapbook series began in 2002 with American Trilogy. This chapbook consists of historical reproductions of the American Declaration of Independence, Constitution, and Bill of Rights, with introductory material by UW Professor Stephen E. Lucas, and an afterword by John P. Kaminski, Director of the Center for the Study of the American Constitution -- published as part of a one year later, university-wide reflection, on the impact of the Sept. 11, 2001, terrorist attacks.

427

Implementing Strategies for Drying and Pressing Wood Without Emissions Controls  

SciTech Connect

Drying and pressing wood for the manufacture of lumber, particleboard, oriented strand board (OSB), veneer and medium density fiberboard (MDF) release volatile organic compounds (VOCs) into the atmosphere. These emissions require control equipment that are capital-intensive and consume significant quantities of natural gas and electricity. The objective of our work was to understand the mechanisms through which volatile organic compounds are generated and released and to develop simple control strategies. Of the several strategies developed, two have been implemented for OSB manufacture over the course of this study. First, it was found that increasing final wood moisture by about 2-4 percentage points reduced the dryer emissions of hazardous air pollutants by over 70%. As wood dries, the escaping water evaporatively cools the wood. This cooling tapers off wood when the wood is nearly dry and the wood temperature rises. Thermal breakdown of the wood tissue occurs and VOCs are released. Raising the final wood moisture by only a few percentage points minimizes the temperature rise and reduces emissions. Evaporative cooling also impacts has implications for VOC release from wood fines. Flaking wood for OSB manufacture inevitable generates fines. Fines dry out rapidly because of their high surface area and evaporative cooling is lost more rapidly than for flakes. As a result, fines emit a disproportionate quantity of VOCs. Fines can be reduced in two ways: through screening of the green furnish and through reducing their generation during flaking. The second approach is preferable because it also increased wood yield. A procedure to do this by matching the sharpness angle of the flaker knife to the ambient temperature was also developed. Other findings of practical interests are as follows: Dielectric heating of wood under low-headspace conditions removes terpenes and other extractives from softwood; The monoterpene content in trees depend upon temperature and seasonal effects; Method 25A emissions from lumber drying can be modeled from a knowledge of the airflow through the kiln; A heat transfer model shows that VOCs released during hot-pressing mainly originate from the surface of the board; and Boiler ash can be used to adsorb formaldehyde from air streams.

Sujit Banerjee; Terrance Conners

2007-09-07

428

Chromosome localization of human genes for clathrin adaptor polypeptides AP2{beta} and AP50 and the clathrin-binding protein, VCP  

SciTech Connect

Clathrin-coated vesicles, involved in endocytosis and Golgi processing, have a surface lattice containing clathrin triskelia and stoichiometric amounts of additional components termed {open_quotes}assembly proteins,{close_quotes} or APs. The AP form at the plasma membrane, AP2, is composed of two large subunits of 100-115 kDa, denoted AP2{alpha} and AP2{beta}, a medium chain of 50 kDa, designated AP50, and a small chain. We have determined human chromosomal locations of genes for a large AP2{beta} (CLAPB1) and a medium (CLAPM1) AP subunit and of a novel clathrin-binding protein, VCP, that binds clathrin simultaneously with A1`s. Chromosomal in situ hybridization of a human genomic clone demonstrated that the CLAPM1 gene mapped to chromosome region 3q28. The gene for the CLAPB1 large subunit was mapped to 17q11.2-q12 by PCR amplification of an AP2{beta} fragment from a panel of rodent-human hybrid DNAs. To map the human VCP sequence, a human-specific probe was made by RT-PCR of human mRNA using oligonucleotide primers from conserved regions of the porcine sequence. The amplified human fragment served as probe on Southern blots of hybrid DNAs to determine that the human VCP locus maps to chromosome region 9pter-q34. 13 refs., 2 figs.

Druck, T.; Gu, Y.; Prabhala, G. [Jefferson Cancer Inst., Philadelphia, PA (United States)] [and others

1995-11-01

429

Introduction to Physics of the Universe in AP Physics Classrooms  

NASA Astrophysics Data System (ADS)

Often students have difficulty understanding the connections that must be made between old and new concepts. This curriculum is designed to lead AP Physics students through this process with gamma ray bursts. Students will participate in various discussions, demonstrations, exercises and activities that lead them through universe basics, life cycles of stars, black holes, the electromagnetic spectrum, and they will learn about various NASA observatories. Ultimately, this will result in a better understanding of how astrophysicists have come to understand the gamma ray burst. This series of lessons was created for the three to four weeks after the AP Physics exam. The curriculum was developed through gathering resources from various scientific organizations, developing new ideas and speaking with scientists at NASA Goddard Space Flight Center. The result is a manual of lesson plans, activities and answer keys for teachers to use in their own classrooms.

Allen, Stephanie L.

2006-12-01

430

Status of APS 1-Mwe Parabolic Trough Project  

SciTech Connect

Arizona Public Service (APS) is currently installing new power facilities to generate a portion of its electricity from solar resources that will satisfy its obligation under the Arizona Environmental Portfolio Standard (EPS). During FY04, APS began construction on a 1-MWe parabolic trough concentrating solar power plant. This plant represents the first parabolic trough plant to begin construction since 1991. Site preparation and construction activities continued throughout much of FY05, and startup activities are planned for Fall 2005 (with completion early in FY06). The plant will be the first commercial deployment of the Solargenix parabolic trough collector technology developed under contract to the National Renewable Energy Laboratory. The plant will use an organic Rankine cycle (ORC) power plant, provided by Ormat. The ORC power plant is much simpler than the conventional steam Rankine cycle plant and allows unattended operation of the facility.

Canada, S.; Brosseau, D.; Kolb, G.; Moore, L.; Cable, R.; Price, H.

2005-11-01

431

Airborne Precision Spacing (APS) Dependent Parallel Arrivals (DPA)  

NASA Technical Reports Server (NTRS)

The Airborne Precision Spacing (APS) team at the NASA Langley Research Center (LaRC) has been developing a concept of operations to extend the current APS concept to support dependent approaches to parallel or converging runways along with the required pilot and controller procedures and pilot interfaces. A staggered operations capability for the Airborne Spacing for Terminal Arrival Routes (ASTAR) tool was developed and designated as ASTAR10. ASTAR10 has reached a sufficient level of maturity to be validated and tested through a fast-time simulation. The purpose of the experiment was to identify and resolve any remaining issues in the ASTAR10 algorithm, as well as put the concept of operations through a practical test.

Smith, Colin L.

2012-01-01

432

Time resolved spectroscopy of the cool Ap star HD 213637*  

NASA Astrophysics Data System (ADS)

We present an analysis of high time resolution spectra of the chemically peculiar Ap star HD 213637. The star shows rapid radial velocity variations with a period close to the photometric pulsation period. Radial velocity pulsation amplitudes vary significantly for different rare earth elements. The highest pulsation amplitudes belong to lines of Tb III (360 m s-1), Pr II (250 m s-1) and Pr III (230 m s-1). We did not detect any pulsations from spectral lines of Eu II and in H?, in contrast to many other roAp stars. We also did not find radial velocity pulsations using spectral lines of other chemical elements, including Mg, Si, Ca, Sc, Cr, Fe, Ni, Y and Ba. There are phase shifts between the maxima of pulsation amplitudes of different rare earth elements and ions, which is evidence of an outwardly running magneto-acoustic wave propagating through the upper stellar atmosphere.

Elkin, V. G.; Kurtz, D. W.; Mathys, G.

2015-02-01

433

CMOS APS digital camera based on enhanced parallel port  

NASA Astrophysics Data System (ADS)

CMOS APS become increasingly competitive with respect to their CCD counterparts, while adding advantages such as no blooming, simpler driving requirements and the potential of on-chip integration of sensor analogue circuitry, and digital processing functions. This paper discusses a CMOS digital camera based on EPP interface. A CMOS APS (OV7110) with VGA resolution (640 x 480) was selected as the image sensor, it can generate digital output of typically an 8 or 16 bit data bus in YUV or RGB mode, all the image controllling, e.g. frame rate, white balance, gamma control and exposure control all can be adjusted through 12C bus. The 12C bus control unit, FIFO and EPP interface, etc. are all integrated within a CPLD. The overall structure, working scheme and performance analyses of the camera were discussed in detail. Several images taken by the camera are provided and a detailed discussion of its quality, processing of image data, etc. is also given.

Liu, Zhi; Yang, Jingyi; Wang, Yefan; Hao, Zhihang

2002-09-01

434

Architecture of the APS real-time orbit feedback system.  

SciTech Connect

The APS Real-Time Orbit Feedback System is designed to stabilize the orbit of the stored positron beam against low-frequency sources such as mechanical vibration and power supply ripple. A distributed array of digital signal processors is used to measure the orbit and compute corrections at a 1kHz rate. The system also provides extensive beam diagnostic tools. This paper describes the architectural aspects of the system and describes how the orbit correction algorithms are implemented.

Carwardine, J. A.; Lenkszus, F. R.

1997-11-21

435

Studies on Nonaluminized High Burning Rate AP-Composite Propellants  

Microsoft Academic Search

This paper discusses the effect of replacement of hydroxyl terminated poly butadiene (HTPB) by butacene on the burning rates of a nonaluminized ammonium perchlorate (AP)based composite propellant. A remarkable burning rate enhancement (60100%) was observed on replacement of HTPB by butacene to the extent of 25%. Replacement of 5075% HTPB by butacene led to further increase in burning rate by

G. M. GORE; A. N. NAZARE; C. N. DIVEKAR; S. K. HAIT; S. N. ASTHANA

2004-01-01

436

APS PhysicsQuest: Ben Franklin's Secret Message (2006)  

NSDL National Science Digital Library

This web site has links to the materials for the 2006 Physics Quest middle school competition, hosted by the APS. The 2006 lesson covers static electricity, conductors and insulators, heat, and optics. These are connected to the life and science of Benjamin Franklin. The experiments are designed for small groups in a classroom or after school setting. Each of the experiments gives students a clue to solve the mystery.

2011-08-12

437

AP600 passive residual heat removal heat exchanger test  

Microsoft Academic Search

The AP600 reactor is a pressurized water reactor being designed to utilize a passive residual heat removal (PRHR) heat exchanger as the safety grade means for residual heat removal. The PRHR heat exchanger is utilized during many design basis events and is especially important in mitigating non-loss-of-coolant accidents such as loss of normal feedwater and feedwater line break. The PRHR

M. M. Corletti; L. E. Hochreiter; D. Squarer

1990-01-01

438

Diffusion and Settling in Ap/Bp Stars  

E-print Network

Ap/Bp stars are magnetic chemically peculiar early A and late B type stars of the main sequence. They exhibit peculiar surface abundance anomalies that are thought to be the result of gravitational settling and radiative levitation. The physics of diffusion in these stars are reviewed briefly and some model predictions are discussed. While models reproduce some observations reasonably well, more work is needed before the behavior of diffusing elements in a complex magnetic field is fully understood.

S. Turcotte

2003-04-23

439

Molecular targets of the antiinflammatory Harpagophytum procumbens (devil's claw): inhibition of TNF? and COX-2 gene expression by preventing activation of AP-1.  

PubMed

Harpagophytum procumbens (Hp) is often used in the supportive treatment of inflammatory and degenerative diseases of the skeletal system. Although the clinical efficacy in osteoarthritis has been demonstrated in clinical trials, the molecular target(s) of Hp are unclear. This study quantified the effects of the ethanol Hp extract (60% v/v ethanol, sole active ingredient of Pascoe-Agil), on the expression and release of the major pro-inflammatory mediators in LPS-stimulated human monocytes and the intracellular signalling pathways involved in inflammation. The Hp extract dose-dependently inhibited the release of TNF? as well as that of interleukin (IL)-6, IL-1? and prostaglandin E? (PGE?). The Hp prevented TNF? and IL-6 mRNA expression in human monocytes and cyclooxygenase-2 (COX-2) in RAW 264.7 cells. Furthermore, the Hp extract inhibited LPS-stimulated AP-1-mediated gene transcription activity and binding to the AP-1 response elements. The extract had no effect on the LPS-induced binding of nuclear factor-?B in RAW 264.7 cells, on LPS-induced degradation of I?B? or on LPS-induced activation of mitogen-activated protein kinases (MAPK), p38MAPK and JNK in human monocytes. The data indicate that a standardized ethanol Hp extract inhibits induction of pro-inflammatory gene expression, possibly by blocking the AP-1 pathway. This is novel evidence of a possible mechanism of action of this antiinflammatory drug. PMID:22072539

Fiebich, Bernd L; Muoz, Eduardo; Rose, Thorsten; Weiss, Gabriele; McGregor, Gerard P

2012-06-01

440

Packaging design criteria, transfer and disposal of 102-AP mixer pump  

SciTech Connect

A mixer pump installed in storage tank 241-AP-102 (102-AP) has failed. This pump is referred to as the 102-AP mixer pump (APMP). The APMP will be removed from 102-AP 1 and a new pump will be installed. The main purpose of the Packaging Design Criteria (PDC) is to establish criteria necessary to design and fabricate a shipping container for the transfer and storage of the APMP from 102-AP. The PDC will be used as a guide to develop a Safety Evaluation for Packaging (SEP).

Carlstrom, R.F.

1994-11-23

441

Margin Assessment of AP1000 Loss of Flow Transient  

SciTech Connect

The Reactor Coolant System (RCS) of the AP1000 plant consists of two circulating loops. Each loop contains two canned motor Reactor Coolant (RC) pumps that have a rotating inertia to provide RCS flow coast-down if power to the pumps is lost. Westinghouse analysis of the complete loss of flow (CLOF) accident in support of the AP1000 design certification was based on the USNRC-approved traditional methodology applied to operating plants. The RCS response during the transient was predicted using the LOFTRAN code based on a reactivity insertion curve highly skewed to the bottom of the reactor core, but the calculation of Departure from Nucleate Boiling Ratio (DNBR) was performed assuming a top-skewed axial power profile. A more realistic margin assessment can be made by using an improved method similar to Westinghouse RAVE methodology recently approved by the USNRC. The improved method uses the three-dimensional kinetic nodal code SPNOVA coupled with the reactor core thermal-hydraulic code VIPRE-W for predicting the reactor core response during the CLOF transient. The improved method significantly improves margin predictions by generating core power distributions consistent with the trip reactivity changes for the DNBR calculation. The margin assessment showed that the improved method resulted in a 19% DNBR increase as compared to the traditional method for the AP1000 CLOF transient. (authors)

Carlin, Edward L.; Hilton, Peter A.; Yixing Sung [Westinghouse Electric Company, LLC (United States)

2006-07-01

442

JUNB/AP-1 controls IFN-? during inflammatory liver disease  

PubMed Central

Understanding the molecular pathogenesis of inflammatory liver disease is essential to design efficient therapeutic approaches. In hepatocytes, the dimeric transcription factor c-JUN/AP-1 is a major mediator of cell survival during hepatitis, although functions for other JUN proteins in liver disease are less defined. Here, we found that JUNB was specifically expressed in human and murine immune cells during acute liver injury. We analyzed the molecular function of JUNB in experimental models of hepatitis, including administration of concanavalin A (ConA) or ?-galactosyl-ceramide, which induce liver inflammation and injury. Mice specifically lacking JUNB in hepatocytes displayed a mild increase in ConA-induced liver damage. However, targeted deletion of Junb in immune cells and hepatocytes protected against hepatitis in experimental models that involved NK/NKT cells. The absence of JUNB in immune cells decreased IFN-? expression and secretion from NK and NKT cells, leading to reduced STAT1 pathway activation. Systemic IFN-? treatment or adenovirus-based IRF1 delivery to Junb-deficient mice restored hepatotoxicity, and we demonstrate that Ifng is a direct transcriptional target of JUNB. These findings demonstrate that JUNB/AP-1 promotes cell death during acute hepatitis by regulating IFN-? production in NK and NKT cells and thus functionally antagonizes the hepatoprotective function of c-JUN/AP-1 in hepatocytes. PMID:24200694

Thomsen, Martin K.; Bakiri, Latifa; Hasenfuss, Sebastian C.; Hamacher, Rainer; Martinez, Lola; Wagner, Erwin F.

2013-01-01

443

Long-term stability of the APS storage ring  

SciTech Connect

The Advanced Photon Source (APS), a third-generation synchrotron light source, was commissioned in 1995 at Argonne National Laboratory and has been fully operational for beamline users since 1997. The APS storage ring can accommodate up to 68 user beamlines; about 70% of the available beamlines are currently in use by various collaborative access teams (CATs). The 7-GeV synchrotron light source produces light in the soft to hard x-ray range that is used for research in such areas as x-ray instrumentation; material, chemical and atomic sciences; biology; and geo/soil/environmental sciences. For the successful operation of an x-ray light source such as the Advanced Photon Source, the long-term stability of the concrete floor supporting the beam components and user beamlines is crucial. Settlements impact the orbit and location of the x-ray source points as well as the position of the x-ray beamlines. This paper compares the results of two successive resurveys of the APS accelerator components performed in 1995 and 1998.

Friedsam, H.; Penicka, M.; Error, J.

2000-03-16

444

Long-term stability of the APS storage ring  

SciTech Connect

The Advanced Photon Source (APS), a third-generation synchrotrons light source, was commissioned in 1995 at Argonne ''National Laboratory and has been fully-operational for beamline users since 1997. The APS storage ring can accommodate up to 68 user beamlines; about 70% of the available beamlines are currently in use by various collaborative access teams (CATS). The 7-GeV synchrotrons light source produces light in the soft to hard x-ray range that is used for research in such areas as x-ray instrumentation; material, chemical and atomic sciences; biology; and geo/soil/ environmental sciences. For the successful operation of an x-ray light source such as the Advanced Photon Source, the long-term stability of the concrete floor supporting the beam components and user beamlines is crucial. Settlements impact the orbit and location of the x-ray source points as well as the position of the x-ray beamlines. This paper compares the results of two successive resurveys of the APS accelerator components performed in 1995 and 1998.

Friedsam, H.; Penicka, M.; Error, J.

1999-10-26

445

Purification of recombinant nacre-associated mineralization protein AP7 fused with maltose-binding protein.  

PubMed

Formation of biominerals often involves specific proteins that modulate the process of matrix assembly, nucleation, and crystal growth. AP7 is an aragonite-associated protein of 7 kDa and is intrinsically disordered. The structural disorder of AP7 makes it very difficult to express in Escherchiacoli. In this work, we report the first successful expression and purification of recombinant AP7 using the maltose-binding protein (MBP) fusion approach. We obtain a high-yield production of recombinant MBP-AP7 protein inE. coli (?60 mg/L). We also establish an efficient protocol to remove the MBP fusion protein by Factor Xa, followed by purification using size-exclusion chromatography. Characterization of the recombinant AP7 protein has been carried out using MALDI-TOF, peptide mass fingerprinting, and circular dichroism (CD). The mass data confirm that the purified recombinant protein is AP7. The CD data suggest that the recombinant AP7 protein exists as partially disordered structure at neutral pH. The calcium carbonate precipitation assay shows that both MBP-AP7 and AP7 exhibit morphological modification on calcite crystallites. The co-precipitation of MBP-tagged AP7 derivatives and calcium carbonate generate different types of AP7 composite calcite and vaterite crystals. This system should be helpful to establish a model for understanding the structure/function relationship between the protein and inorganic mineral interaction. PMID:24837160

Huang, Yu-Chieh; Chang, Hsun-Hui; Mou, Yun; Chi, Peter; Chan, Jerry Chun Chung; Luo, Shih-Chi

2014-08-01

446

The interaction between the adaptor protein APS and Enigma is involved in actin organisation.  

PubMed

APS (adaptor protein with PH and SH2 domains) is an adaptor protein phosphorylated by several tyrosine kinase receptors including the insulin receptor. To identify novel binding partners of APS, we performed yeast two-hybrid screening. We identified Enigma, a PDZ and LIM domain-containing protein that was previously shown to be associated with the actin cytoskeleton. In HEK 293 cells, Enigma interacted specifically with APS, but not with the APS-related protein SH2-B. This interaction required the NPTY motif of APS and the LIM domains of Enigma. In NIH-3T3 cells that express the insulin receptor, Enigma and APS were partially co-localised with F-actin in small ruffling structures. Insulin increased the complex formation between APS and Enigma and their co-localisation in large F-actin containing ruffles. While in NIH-3T3 and HeLa cells the co-expression of both Enigma and APS did not modify the actin cytoskeleton organisation, expression of Enigma alone led to the formation of F-actin clusters. Similar alteration in actin cytoskeleton organisation was observed in cells expressing both Enigma and APS with a mutation in the NPTY motif. These results identify Enigma as a novel APS-binding protein and suggest that the APS/Enigma complex plays a critical role in actin cytoskeleton organisation. PMID:15946664

Barrs, Romain; Gonzalez, Teresa; Le Marchand-Brustel, Yannick; Tanti, Jean-Franois

2005-08-15

447

Textbook Sales Drop, and University Presses Search for Reasons  

ERIC Educational Resources Information Center

This article reports that textbook sales are falling at many university presses, a trend that has accelerated in the past couple of months. That's the word from press directors anxious about the decline but unsure what's causing it or how to stop it. Not every press has been affected. Two of the biggest players, Oxford University Press and

Howard, Jennifer

2008-01-01

448

NF-?B/AP-1-Targeted Inhibition of Macrophage-Mediated Inflammatory Responses by Depigmenting Compound AP736 Derived from Natural 1,3-Diphenylpropane Skeleton  

PubMed Central

AP736 was identified as an antimelanogenic drug that can be used for the prevention of melasma, freckles, and dark spots in skin by acting as a suppressor of melanin synthesis and tyrosinase expression. Since macrophage-mediated inflammatory responses are critical for skin health, here we investigated the potential anti-inflammatory activity of AP736. The effects of AP736 on various inflammatory events such as nitric oxide (NO)/prostaglandin (PG) E2 production, inflammatory gene expression, phagocytic uptake, and morphological changes were examined in RAW264.7 cells. AP736 was found to strongly inhibit the production of both NO and PGE2 in lipopolysaccharide- (LPS-) treated RAW264.7 cells. In addition, AP736 strongly inhibited both LPS-induced morphological changes and FITC-dextran-induced phagocytic uptake. Furthermore, AP736 also downregulated the expression of multiple inflammatory genes, such as inducible NO synthase (iNOS), cyclooxygenase- (COX-) 2, and interleukin- (IL-) 1? in LPS-treated RAW264.7 cells. Transcription factor analysis, including upstream signalling events, revealed that both NF-?B and AP-1 were targeted by AP736 via inhibition of the IKK/I?B? and IRAK1/TAK1 pathways. Therefore, our results strongly suggest that AP736 is a potential anti-inflammatory drug due to its suppression of NF-?B-IKK/I?B? and AP-1-IRAK1/TAK1 signalling, which may make AP736 useful for the treatment of macrophage-mediated skin inflammation. PMID:25386046

Ha, Van Thai; Beak, Heung Soo; Kim, Eunji; Baek, Kwang-Soo; Hossen, Muhammad Jahangir; Yang, Woo Seok; Kim, Yong; Joo, Yung Hyup; Lee, Chang Seok; Choi, Joonho; Shin, Hong-Ju; Hong, Sungyoul; Shin, Song Seok

2014-01-01

449

CSA/ASC Press Briefing  

NASA Technical Reports Server (NTRS)

Nicole Gignac, Senior Communications Advisor Canadian Space Agency (CSA), introduces the panel for this CSA/ASC press briefing. The panel consist of: Dr. Steve Maclean, CSA astronaut; Dr. Paul Cooper, Deputy General Manager, MacDonald, Dettwiler and Associates Ltd. (MDA); and Dr. Iain Christie, Director of Research and Development from NEPTEC. Maclean will fly on the STS-115 Mission in February of 2006. He presents pictures and talks about the crewmembers of the Space Shuttle Columbia and Space Shuttle Discovery. Maclean also discusses entry risks as it pertains to the leading edge wing of Discovery. Paul Cooper explains and shows a video presentation of Canadarm robotics. The briefing ends with Dr Christie explaining the sensitive three dimensional inspections are performed in space that looks for cracks in the leading edge wing of the Space Shuttle Discovery.

2005-01-01

450

NRC confirmatory AP600 safety system phase I testing in the ROSA/AP600 test facility  

SciTech Connect

The NRC confirmatory phase I testing for the AP600 safety systems has been completed in the modified ROSA (Rig of Safety Assessment) test facility located at the Japan Atomic Energy Research Institute (JAERI) campus in Tokai, Japan. The test matrix included a variety of accident scenarios covering both design and beyond-design basis accidents. The test results indicate the AP600 safety systems as reflected in ROSA appear to perform as designed and there is no danger of core heatup for the accident scenarios investigated. In addition, no detrimental system interactions nor adverse effects of non-safety systems on the safety system functions were identified. However, three phenomena of interest have been identified for further examination to determine whether they are relevant to the AP600 plant. Those three phenomena are: (1) a potential for water hammer caused by rapid condensation which may occur following the actuation of the automatic depressurization system (ADS), (2) a large thermal gradient in the cold leg pipe where cooled water returns from the passive residual heat removal system and forms a thermally stratified layer, and (3) system-wide oscillations initiating following the ADS stage 4 actuation and persisting until the liquid in the pressurizer drains and steam generation in the core becomes insignificant.

Rhee, G.S.; Kukita, Yutaka; Schultz, R.R.

1996-03-01

451

TOXICS RELEASE INVENTORY (TRI)  

EPA Science Inventory

The Toxics Release Inventory (TRI) site is designed to provide information on toxic chemical releases including collected data, guidance documents, program planning, background, history, and, program contacts, among other things. The data included in this homepage have been submi...

452

Berberine Targets AP-2/hTERT, NF-?B/COX-2, HIF-1?/VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell Growth.  

PubMed

Berberine (BBR), an isoquinoline derivative alkaloid isolated from Chinese herbs, has a long history of uses for the treatment of multiple diseases, including cancers. However, the precise mechanisms of actions of BBR in human lung cancer cells remain unclear. In this study, we investigated the molecular mechanisms by which BBR inhibits cell growth in human non-small-cell lung cancer (NSCLC) cells. Treatment with BBR promoted cell morphology change, inhibited cell migration, proliferation and colony formation, and induced cell apoptosis. Further molecular mechanism study showed that BBR simultaneously targeted multiple cell signaling pathways to inhibit NSCLC cell growth. Treatment with BBR inhibited AP-2? and AP-2? expression and abrogated their binding on hTERT promoters, thereby inhibiting hTERT expression. Knockdown of AP-2? and AP-2? by siRNA considerably augmented the BBR-mediated inhibition of cell growth. BBR also suppressed the nuclear translocation of p50/p65 NF-?B proteins and their binding to COX-2 promoter, causing inhibition of COX-2. BBR also downregulated HIF-1? and VEGF expression and inhibited Akt and ERK phosphorylation. Knockdown of HIF-1? by siRNA considerably augmented the BBR-mediated inhibition of cell growth. Moreover, BBR treatment triggered cytochrome-c release from mitochondrial inter-membrane space into cytosol, promoted cleavage of caspase and PARP, and affected expression of BAX and Bcl-2, thereby activating apoptotic pathway. Taken together, these results demonstrated that BBR inhibited NSCLC cell growth by simultaneously targeting AP-2/hTERT, NF-?B/COX-2, HIF-1?/VEGF, PI3K/AKT, Raf/MEK/ERK and cytochrome-c/caspase signaling pathways. Our findings provide new insights into understanding the anticancer mechanisms of BBR in human lung cancer therapy. PMID:23869238

Fu, Lingyi; Chen, Wangbing; Guo, Wei; Wang, Jingshu; Tian, Yun; Shi, Dingbo; Zhang, Xiaohong; Qiu, Huijuan; Xiao, Xiangsheng; Kang, Tiebang; Huang, Wenlin; Wang, Shusen; Deng, Wuguo

2013-01-01

453

Phenomena identification and ranking tables for Westinghouse AP600 small break loss-of-coolant accident, main steam line break, and steam generator tube rupture scenarios  

SciTech Connect

This report revision incorporates new experimental evidence regarding AP600 behavior during small break loss-of-coolant accidents. This report documents the results of Phenomena Identification and Ranking Table (PIRT) efforts for the Westinghouse AP600 reactor. The purpose of this PIRT is to identify important phenomena so that they may be addressed in both the experimental programs and the RELAP5/MOD3 systems analysis computer code. In Revision of this report, the responses of AP600 during small break loss-of-coolant accident, main steam line break, and steam generator tube rupture accident scenarios were evaluated by a committee of thermal-hydraulic experts. Committee membership included Idaho National Engineering and Environmental Laboratory staff and recognized thermal-hydraulic experts from outside of the laboratory. Each of the accident scenarios was subdivided into separate, sequential periods or phases. Within each phase, the plant behavior is controlled by, at most, a few thermal-hydraulic processes. The committee identified the phenomena influencing those processes, and ranked & influences as being of high, medium, low, or insignificant importance. The primary product of this effort is a series of tables, one for each phase of each accident scenario, describing the thermal-hydraulic phenomena judged by the committee to be important, and the relative ranking of that importance. The rationales for the phenomena selected and their rankings are provided. This document issue incorporates an update of the small break loss-of-coolant accident portion of the report. This revision is the result of the release of experimental evidence from AP600-related integral test facilities (ROSA/AP600, OSU, and SPES) and thermal-hydraulic expert review. The activities associated with this update were performed during the period from June 1995 through November 1996. 8 refs., 26 figs., 42 tabs.

Wilson, G.E.; Fletcher, C.D.; Davis, C.B. [and others

1997-06-01

454

NEWS RELEASE PRESSOFFICE  

E-print Network

NEWS RELEASE PRESSOFFICE Release Date: April 18, 2008 Contact: Christine Mangi (202) 205-6948 Release Number: 08-35 Internet Address: www.sba.gov/news/ SBA TO PARTNER WITH THE U.S.-INDIA BUSINESS development programs and services, disseminate current SBA news and information, provide speakers for SBA

455

National Pollutant Release Inventory  

NSDL National Science Digital Library

The National Pollutant Release Inventory is maintained by Environment Canada and provides access to pollutant release information for facilities located throughout Canada. The data can be searched by chemical name and location, and results provide detailed information on the substance, its release, its disposal, and its transfer at a particular facility.

456

Biomagnetic of Apatite-Coated Cobalt Ferrite: A Core-Shell Particle for Protein Adsorption and pH-Controlled Release  

NASA Astrophysics Data System (ADS)

Magnetic nanoparticle composite with a cobalt ferrite (CoFe2O4, (CF)) core and an apatite (Ap) coating was synthesized using a biomineralization process in which a modified simulated body fluid (1.5SBF) solution is the source of the calcium phosphate for the apatite formation. The core-shell structure formed after the citric acid-stabilized cobalt ferrite (CFCA) particles were incubated in the 1.5 SBF solution for 1 week. The mean particle size of CFCA-Ap is about 750 nm. A saturation magnetization of 15.56 emug-1 and a coercivity of 1808.5 Oe were observed for the CFCA-Ap obtained. Bovine serum albumin (BSA) was used as the model protein to study the adsorption and release of the proteins by the CFCA-Ap particles. The protein adsorption by the CFCA-Ap particles followed a more typical Freundlich than Langmuir adsorption isotherm. The BSA release as a function of time became less rapid as the CFCA-Ap particles were immersed in higher pH solution, thus indicating that the BSA release is dependent on the local pH.

Tang, I.-Ming; Krishnamra, Nateetip; Charoenphandhu, Narattaphol; Hoonsawat, Rassmidara; Pon-On, Weeraphat

2010-12-01

457

Biomagnetic of Apatite-Coated Cobalt Ferrite: A CoreShell Particle for Protein Adsorption and pH-Controlled Release  

PubMed Central

Magnetic nanoparticle composite with a cobalt ferrite (CoFe2O4, (CF)) core and an apatite (Ap) coating was synthesized using a biomineralization process in which a modified simulated body fluid (1.5SBF) solution is the source of the calcium phosphate for the apatite formation. The coreshell structure formed after the citric acidstabilized cobalt ferrite (CFCA) particles were incubated in the 1.5 SBF solution for 1 week. The mean particle size of CFCA-Ap is about 750 nm. A saturation magnetization of 15.56 emug-1 and a coercivity of 1808.5 Oe were observed for the CFCA-Ap obtained. Bovine serum albumin (BSA) was used as the model protein to study the adsorption and release of the proteins by the CFCA-Ap particles. The protein adsorption by the CFCA-Ap particles followed a more typical Freundlich than Langmuir adsorption isotherm. The BSA release as a function of time became less rapid as the CFCA-Ap particles were immersed in higher pH solution, thus indicating that the BSA release is dependent on the local pH.

2011-01-01

458

Implementation and Initial Validation of the APS English Test [and] The APS English-Writing Test at Golden West College: Evidence for Predictive Validity.  

ERIC Educational Resources Information Center

In May 1991, Golden West College (California) conducted a validation study of the English portion of the Assessment and Placement Services for Community Colleges (APS), followed by a predictive validity study in July 1991. The initial study was designed to aid in the implementation of the new test at GWC by comparing data on APS use at other

Isonio, Steven

459

Retinoic Acid Receptors Inhibit AP1 Activation by Regulating Extracellular Signal-Regulated Kinase and CBP Recruitment to an AP1-Responsive Promoter  

PubMed Central

Retinoids exhibit antineoplastic activities that may be linked to retinoid receptor-mediated transrepression of activating protein 1 (AP1), a heterodimeric transcription factor composed of fos- and jun-related proteins. Here we show that transcriptional activation of an AP1-regulated gene through the mitogen-activated protein kinase (MAPK)-extracellular signal-regulated kinase (ERK) pathway (MAPKERK) is characterized, in intact cells, by a switch from a fra2-junD dimer to a junD-fosB dimer loading on its promoter and by simultaneous recruitment of ERKs, CREB-binding protein (CBP), and RNA polymerase II. All-trans-retinoic acid (atRA) receptor (RAR) was tethered constitutively to the AP1 promoter. AP1 transrepression by retinoic acid was concomitant to glycogen synthase kinase 3 activation, negative regulation of junD hyperphosphorylation, and to decreased RNA polymerase II recruitment. Under these conditions, fra1 loading to the AP1 response element was strongly increased. Importantly, CBP and ERKs were excluded from the promoter in the presence of atRA. AP1 transrepression by retinoids was RAR and ligand dependent, but none of the functions required for RAR-mediated transactivation was necessary for AP1 transrepression. These results indicate that transrepressive effects of retinoids are mediated through a mechanism unrelated to transcriptional activation, involving the RAR-dependent control of transcription factors and cofactor assembly on AP1-regulated promoters. PMID:12052862

Benkoussa, Madjid; Brand, Cline; Delmotte, Marie-Hlne; Formstecher, Pierre; Lefebvre, Philippe

2002-01-01

460

ISES-AP -3rd International Solar Energy Society Conference Asia Pacific Region (ISES-AP-08) Incorporating the 46th ANZSES Conference  

E-print Network

ISES-AP - 3rd International Solar Energy Society Conference ­ Asia Pacific Region (ISES-AP-08, the pro-rated to lifetime embodied energy of all the piping systems and the pumping energy involved medium. INTRODUCTION Solar radiation can be harvested as biomass, a sustainable source of energy

461

X Linkage of AP3A, a Homolog of the Y-Linked MADS-Box Gene AP3Y in Silene latifolia and S. dioica  

PubMed Central

Background The duplication of autosomal genes onto the Y chromosome may be an important element in the evolution of sexual dimorphism.A previous cytological study reported on a putative example of such a duplication event in a dioecious tribe of Silene (Caryophyllaceae): it was inferred that the Y-linked MADS-box gene AP3Y originated from a duplication of the reportedly autosomal orthologAP3A. However, a recent study, also using cytological methods, indicated that AP3A is X-linked in Silenelatifolia. Methodology/Principal Findings In this study, we hybridized S. latifolia and S. dioicato investigate whether the pattern of X linkage is consistent among distinct populations, occurs in both species, and is robust to genetic methods. We found inheritance patterns indicative of X linkage of AP3A in widely distributed populations of both species. Conclusions/Significance X linkage ofAP3A and Y linkage of AP3Yin both species indicates that the genes' ancestral progenitor resided on the autosomes that gave rise to the sex chromosomesand that neither gene has moved between chromosomes since species divergence.Consequently, our results do not support the contention that inter-chromosomal gene transfer occurred in the evolution of SlAP3Y from SlAP3A. PMID:21533056

Penny, Rebecca H.; Montgomery, Benjamin R.; Delph, Lynda F.

2011-01-01

462

A Gonadotropin-Releasing Hormone-Like Molecule Modulates the Activity of Diverse Central Neurons in a Gastropod Mollusk, Aplysia Californica  

PubMed Central

In vertebrates, gonadotropin-releasing hormone (GnRH) is a crucial decapeptide that activates the hypothalamicpituitarygonadal axis to ensure successful reproduction. Recently, a GnRH-like molecule has been isolated from a gastropod mollusk, Aplysia californica. This GnRH (ap-GnRH) is deduced to be an undecapeptide, and its function remains to be explored. Our previous study demonstrated that ap-GnRH did not stimulate a range of reproductive parameters. Instead, it affected acute behavioral and locomotive changes unrelated to reproduction. In this study, we used electrophysiology and retrograde tracing to further explore the central role of ap-GnRH. Sharp-electrode intracellular recordings revealed that ap-GnRH had diverse effects on central neurons that ranged from excitatory, inhibitory, to the alteration of membrane potential. Unexpectedly, extracellular recordings revealed that ap-GnRH suppressed the onset of electrical afterdischarge in bag cell neurons, suggesting an inhibitory effect on female reproduction. Lastly, using immunocytochemistry coupled with nickel backfill, we demonstrated that some ap-GnRH neurons projected to efferent nerves known to innervate the foot and parapodia, suggesting ap-GnRH may directly modulate the motor output of these peripheral tissues. Overall, our results suggested that in A. californica, ap-GnRH more likely functioned as a central modulator of complex behavior and motor regulation rather than as a conventional reproductive stimulator. PMID:22654804

Sun, Biao; Tsai, Pei-San

2011-01-01

463

A gonadotropin-releasing hormone-like molecule modulates the activity of diverse central neurons in a gastropod mollusk, aplysia californica.  

PubMed

In vertebrates, gonadotropin-releasing hormone (GnRH) is a crucial decapeptide that activates the hypothalamic-pituitary-gonadal axis to ensure successful reproduction. Recently, a GnRH-like molecule has been isolated from a gastropod mollusk, Aplysia californica. This GnRH (ap-GnRH) is deduced to be an undecapeptide, and its function remains to be explored. Our previous study demonstrated that ap-GnRH did not stimulate a range of reproductive parameters. Instead, it affected acute behavioral and locomotive changes unrelated to reproduction. In this study, we used electrophysiology and retrograde tracing to further explore the central role of ap-GnRH. Sharp-electrode intracellular recordings revealed that ap-GnRH had diverse effects on central neurons that ranged from excitatory, inhibitory, to the alteration of membrane potential. Unexpectedly, extracellular recordings revealed that ap-GnRH suppressed the onset of electrical afterdischarge in bag cell neurons, suggesting an inhibitory effect on female reproduction. Lastly, using immunocytochemistry coupled with nickel backfill, we demonstrated that some ap-GnRH neurons projected to efferent nerves known to innervate the foot and parapodia, suggesting ap-GnRH may directly modulate the motor output of these peripheral tissues. Overall, our results suggested that in A. californica, ap-GnRH more likely functioned as a central modulator of complex behavior and motor regulation rather than as a conventional reproductive stimulator. PMID:22654804

Sun, Biao; Tsai, Pei-San

2011-01-01

464

Thermal Conductances of Pressed Copper Contacts  

NASA Technical Reports Server (NTRS)

Report describes investigation of thermal conductivities of smooth copper contacts pressed together at liquid-helium temperatures. Investigation prompted by need for accurate thermal models for infrared detectors and other cryogenic instruments.

Salerno, L.; Kittel, P.; Spivak, A.

1986-01-01

465

Gas-driven filter pressing in magmas  

USGS Publications Warehouse

Most silicic and some mafic magmas expand via second boiling if they crystallize at depths of about 10 km or less. The buildup of gas pressure due to second boiling can be relieved by expulsion of melt out of the region of crystallization, and this process of gas-driven filter pressing assists the crystallization differentiation of magmas. For gas-driven filter pressing to be effective, the region of crystallization must inflate slowly relative to buildup of pressure and expulsion of melt These conditions are satisfied in undercooled magmatic inclusions and in thin sheets of primitive magma underplating cooler magma reservoirs. Gas-driven filter pressing thereby adds fractionated melt to magma bodies. Gas-driven filter pressing is probably the dominant process by which highly evolved melts segregate from crystal mush to form aplitic dikes in granitic plutons; this process could also account for the production of voluminous, crystal-poor rhyolites.

Sisson, T.W.; Bacon, C.R.

1999-01-01

466

AP180 couples protein retrieval to clathrin-mediated endocytosis of synaptic vesicles.  

PubMed

How clathrin-mediated endocytosis (CME) retrieves vesicle proteins into newly formed synaptic vesicles (SVs) remains a major puzzle. Besides its roles in stimulating clathrin-coated vesicle formation and regulating SV size, the clathrin assembly protein AP180 has been identified as a key player in retrieving SV proteins. The mechanisms by which AP180 recruits SV proteins are not fully understood. Here, we show that following acute inactivation of AP180 in Drosophila, SV recycling is severely impaired at the larval neuromuscular synapse based on analyses of FM 1-43 uptake and synaptic ultrastructure. More dramatically, AP180 activity is important to maintain the integrity of SV protein complexes at the plasma membrane during endocytosis. These observations suggest that AP180 normally clusters SV proteins together during recycling. Consistent with this notion, SV protein composition and distribution are altered in AP180 mutant flies. Finally, AP180 co-immunoprecipitates with SV proteins, including the vesicular glutamate transporter and neuronal synaptobrevin. These results reveal a new mode by which AP180 couples protein retrieval to CME of SVs. AP180 is also genetically linked to Alzheimer's disease. Hence, the findings of this study may provide new mechanistic insight into the role of AP180 dysfunction in Alzheimer's disease. PMID:24456281

Vanlandingham, Phillip A; Barmchi, Mojgan Padash; Royer, Suzanne; Green, Rebekah; Bao, Hong; Reist, Noreen; Zhang, Bing

2014-04-01

467

Effects of synthetic analogues of poly-APS on contractile response of porcine coronary arteries.  

PubMed

APS12-2 and APS3 are synthetic analogues of polymeric alkylpyridinium salts (poly-APS) isolated from the marine sponge Reniera sarai. The aim of the present study was to determine the possible direct contractile effects of these two synthetic molecules on coronary arteries, in order partly to explain hemodynamic and cardiotoxic effects of APS12-2 previously observed in in vivo studies and to reveal possible adverse effects on the organism in the case of their clinical use. In contrast to APS3, APS12-2 caused a concentration-dependent vascular smooth muscle contraction of isolated porcine coronary ring preparations in a concentration-range from 1.36 to 13.60?M. Lanthanum chloride (5mM) and verapamil (10?M) completely abolished the APS12-2 evoked contraction of the coronary rings. Pre-incubation with indomethacin (10?M) had no effect on the contractile responses of coronary ring preparations. These results indicate that APS12-2 contracts vascular smooth muscle in a concentration-dependent manner, due to an increase of Ca(2+) influx through the voltage-gated Ca(2+) channels. Our data show for the first time that APS12-2 induces concentration-dependent contraction of coronary ring preparations, which may contribute to the cardiotoxic effects of APS12-2, in addition to hyperkalemia. PMID:23178276

Grandi?, Marjana; Bajuk, Blanka Premrov; Sep?i?, Kristina; Koorok, Marinka Drobni?; Frange, Robert

2013-03-01

468

Induction of neural crest in Xenopus by transcription factor AP2?  

PubMed Central

We report experiments with Xenopus laevis, using both intact embryos and ectodermal explants, showing that the transcription factor AP2? is positively regulated by bone morphogenetic protein (BMP) and Wnt signaling, and that this activation is an essential step in the induction of neural crest (NC). Ectopic expression of AP2? is sufficient to activate high-level expression of NC-specific genes such as Slug and Sox9, which can occur as isolated domains within the neural plate as well as by expansion of endogenous NC territories. AP2? also has the property of inducing NC in isolated ectoderm in which Wnt signaling is provided but BMP signaling is minimized by overexpression of chordin. Like other NC regulatory factors, activation of AP2? requires some attenuation of endogenous BMP signaling; however, this process occurs at a lower threshold for AP2?. Furthermore, AP2? expression domains are larger than for other NC factors. Loss-of-function experiments with antisense AP2? morpholino oligonucleotides result in severe reduction in the NC territory. These results support a central role for AP2? in NC induction. We propose a model in which AP2? expression, along with inactivation of NC inhibitory factors such as Dlx3, establish a feedback loop comprising AP2?, Sox9, and Slug, leading to and maintaining NC specification. PMID:12511599

Luo, Ting; Lee, Young-Hoon; Saint-Jeannet, Jean-Pierre; Sargent, Thomas D.

2003-01-01

469

AP180 Couples Protein Retrieval to Clathrin-Mediated Endocytosis of Synaptic Vesicles  

PubMed Central

How clathrin-mediated endocytosis (CME) retrieves vesicle proteins into newly formed synaptic vesicles (SVs) remains a major puzzle. Besides its roles in stimulating clathrin-coated vesicle formation and regulating SV size, the clathrin assembly protein AP180 has been identified as a key player in retrieving SV proteins. The mechanisms by which AP180 recruits SV proteins are not fully understood. Here, we show that following acute inactivation of AP180 in Drosophila, SV recycling is severely impaired at the larval neuromuscular synapse based on analyses of FM 1-43 uptake and synaptic ultrastructure. More dramatically, AP180 activity is important to maintain the integrity of SV protein complexes at the plasma membrane during endocytosis. These observations suggest that AP180 normally clusters SV proteins together during recycling. Consistent with this notion, SV protein composition and distribution are altered in AP180 mutant flies. Finally, AP180 co-immunoprecipitates with SV proteins, including the vesicular glutamate transporter and neuronal synaptobrevin. These results reveal a new mode by which AP180 couples protein retrieval to CME of SVs. AP180 is also genetically linked to Alzheimer's disease. Hence, the findings of this study may provide new mechanistic insight into the role of AP180 dysfunction in Alzheimer's disease. PMID:24456281

Vanlandingham, Phillip A; Barmchi, Mojgan Padash; Royer, Suzanne; Green, Rebekah; Bao, Hong; Reist, Noreen; Zhang, Bing

2014-01-01

470

The clathrin adaptor complex AP-2 mediates endocytosis of brassinosteroid insensitive1 in Arabidopsis.  

PubMed

Clathrin-mediated endocytosis (CME) regulates many aspects of plant development, including hormone signaling and responses to environmental stresses. Despite the importance of this process, the machinery that regulates CME in plants is largely unknown. In mammals, the heterotetrameric adaptor protein complex-2 (AP-2) is required for the formation of clathrin-coated vesicles at the plasma membrane (PM). Although the existence of AP-2 has been predicted in Arabidopsis thaliana, the biochemistry and functionality of the complex is still uncharacterized. Here, we identified all the subunits of the Arabidopsis AP-2 by tandem affinity purification and found that one of the large AP-2 subunits, AP2A1, localized at the PM and interacted with clathrin. Furthermore, endocytosis of the leucine-rich repeat receptor kinase, brassinosteroid insensitive1 (BRI1), was shown to depend on AP-2. Knockdown of the two Arabidopsis AP2A genes or overexpression of a dominant-negative version of the medium AP-2 subunit, AP2M, impaired BRI1 endocytosis and enhanced the brassinosteroid signaling. Our data reveal that the CME machinery in Arabidopsis is evolutionarily conserved and that AP-2 functions in receptor-mediated endocytosis. PMID:23975899

Di Rubbo, Simone; Irani, Niloufer G; Kim, Soo Youn; Xu, Zheng-Yi; Gadeyne, Astrid; Dejonghe, Wim; Vanhoutte, Isabelle; Persiau, Geert; Eeckhout, Dominique; Simon, Sibu; Song, Kyungyoung; Kleine-Vehn, Jrgen; Friml, Jir; De Jaeger, Geert; Van Damme, Danil; Hwang, Inhwan; Russinova, Eugenia

2013-08-01

471

RAD51AP2, a novel vertebrate- and meiotic-specific protein, sharesa conserved RAD51-interacting C-terminal domain with RAD51AP1/PIR51  

SciTech Connect

Many interacting proteins regulate and/or assist the activities of RAD51, a recombinase which plays a critical role in both DNA repair and meiotic recombination. Yeast two-hybrid screening of a human testis cDNA library revealed a new protein, RAD51AP2 (RAD51 Associated Protein 2), that interacts strongly with RAD51. A full-length cDNA clone predicts a novel vertebrate specific protein of 1159 residues, and the RAD51AP2 transcript was observed only in meiotic tissue (i.e. adult testis and fetal ovary), suggesting a meiotic-specific function for RAD51AP2. In HEK293 cells the interaction of RAD51 with an ectopically-expressed recombinant large fragment of RAD51AP2 requires the C-terminal 57 residues of RAD51AP2. This RAD51-binding region shows 81% homology to the C-terminus of RAD51AP1/PIR51, an otherwise totally unrelated RAD51-binding partner that is ubiquitously expressed. Analyses using truncations and point mutations in both RAD51AP1 and RAD51AP2 demonstrate that these proteins use the same structural motif for RAD51 binding. RAD54 shares some homology with this RAD51-binding motif, but this homologous region plays only an accessory role to the adjacent main RAD51-interacting region, which has been narrowed here to 40 amino acids. A novel protein, RAD51AP2, has been discovered that interacts with RAD51 through a C-terminal motif also present in RAD51AP1.

Kovalenko, Oleg V.; Wiese, Claudia; Schild, David

2006-07-25

472

Replacing the axial ligand tyrosine 75 or its hydrogen bond partner histidine 83 minimally affects hemin acquisition by the hemophore HasAp from Pseudomonas aeruginosa.  

PubMed

Hemophores from Pseudomonas aeruginosa (HasAp), Serratia marcescens (HasAsm), and Yersinia pestis (HasAyp) bind hemin between two loops. One of the loops harbors conserved axial ligand Tyr75 (Y75 loop) in all three structures, whereas the second loop (H32 loop) contains axial ligand His32 in HasAp and HasAsm, but a noncoordinating Gln32 in HasAyp. Binding of hemin to the Y75 loop of HasAp or HasAsm causes a large rearrangement of the H32 loop that allows His32 coordination. The Q32 loop in apo-HasAyp is already in the closed conformation, such that binding of hemin to the conserved Y75 loop occurs with minimal structural rearrangement and without coordinative interaction with the Q32 loop. In this study, structural and spectroscopic investigations of the hemophore HasAp were conducted to probe (i) the role of the conserved Tyr75 loop in hemin binding and (ii) the proposed requirement of the His83-Tyr75 hydrogen bond to allow the coordination of hemin by Tyr75. High-resolution crystal structures of H83A holo-HasAp obtained at pH 6.5 (0.89 ) and pH 5.4 (1.25 ) show that Tyr75 remains coordinated to the heme iron, and that a water molecule can substitute for N? of His83 to interact with the O? atom of Tyr75, likely stabilizing the Tyr75-Fe interaction. Nuclear magnetic resonance spectroscopy revealed that in apo-Y75A and apo-H83A HasAp, the Y75 loop is disordered, and that disorder propagates to nearby elements of secondary structure, suggesting that His83 N?-Tyr75 O? interaction is important to the organization of the Y75 loop in apo-HasA. Kinetic analysis of hemin loading conducted via stopped-flow UV-vis and rapid-freeze-quench resonance Raman shows that both mutants load hemin with biphasic kinetic parameters that are not significantly dissimilar from those previously observed for wild-type HasAp. When the structural and kinetic data are taken together, a tentative model emerges, which suggests that HasA hemophores utilize hydrophobic, ?-? stacking, and van der Waals interactions to load hemin efficiently, while axial ligation likely functions to slow hemin release, thus allowing the hemophore to meet the challenge of capturing hemin under inhospitable conditions and delivering it selectively to its cognate receptor. PMID:24625274

Kumar, Ritesh; Matsumura, Hirotoshi; Lovell, Scott; Yao, Huili; Rodrguez, Juan C; Battaile, Kevin P; Monne-Loccoz, Pierre; Rivera, Mario

2014-04-01

473

ApiAP2 transcription factor restricts development of the Toxoplasma tissue cyst  

PubMed Central

Cellular differentiation leading to formation of the bradyzoite tissue cyst stage is the underlying cause of chronic toxoplasmosis. Consequently, mechanisms responsible for controlling development in the Toxoplasma intermediate life cycle have long been sought. Here, we identified 15 Toxoplasma mRNAs induced in early bradyzoite development that encode proteins with apicomplexan AP2 (ApiAP2) DNA binding domains. Of these 15 mRNAs, the AP2IX-9 mRNA demonstrated the largest expression increase during alkaline-induced differentiation. At the protein level, we found that AP2IX-9 was restricted to the early bradyzoite nucleus and is repressed in tachyzoites and in mature bradyzoites from 30-d infected animals. Conditional overexpression of AP2IX-9 significantly reduced tissue cyst formation and conferred alkaline pH-resistant growth, whereas disruption of the AP2IX-9 gene increased tissue cyst formation, indicating AP2IX-9 operates as a repressor of bradyzoite development. Consistent with a role as a repressor, AP2IX-9 specifically inhibited the expression of bradyzoite mRNAs, including the canonical bradyzoite marker, bradyzoite antigen 1 (BAG1). Using protein binding microarrays, we established the AP2 domain of AP2IX-9 binds a CAGTGT DNA sequence motif and is capable of binding cis-regulatory elements controlling the BAG1 and bradyzoite-specific nucleoside triphosphatase (B-NTPase) promoters. The effect of AP2IX-9 on BAG1 expression was direct because this factor inhibits expression of a firefly luciferase reporter under the control of the BAG1 promoter in vivo, and epitope-tagged AP2IX-9 can be immunoprecipitated with the BAG1 promoter in parasite chromatin. Altogether, these results indicate AP2IX-9 restricts Toxoplasma commitment to develop the mature bradyzoite tissue cyst. PMID:23572590

Radke, Joshua B.; Lucas, Olivier; De Silva, Erandi K.; Ma, YanFen; Sullivan, William J.; Weiss, Louis M.; Llinas, Manuel; White, Michael W.

2013-01-01

474

The control of press cleaning solvent vapors in a small lithographic printing establishment.  

PubMed

Small businesses frequently have inadequate in-house expertise to solve a variety of safety and health problems. The National Institute for Occupational Safety and Health (NIOSH) has therefore conducted a demonstration project in the commercial lithographic printing industry, which consists largely of small companies, in an effort to establish suitable control technology for airborne solvent vapors released primarily during press cleaning operations. These solvent vapors have a number of potential adverse health effects, including narcosis, kidney and liver damage, and cancer. Also, airborne anti-offset powder is a potential allergic sensitizer and cause of occupational asthma. As a means of controlling worker exposures to the vapors and dust, a local exhaust inlet was attached to the side of the press adjacent to the paper delivery point. Tempered outside air was introduced through ceiling outlets installed to make up for the exhausted air. Measurements of press operator exposure and area concentrations of solvent vapors and area concentration of anti-offset powder were made before and after installation of the new ventilation controls. Vapor concentrations were reduced by 73 percent for the press operators. Area concentrations of the vapors were reduced by 86 percent and dust concentration by 67 percent. The ventilation system was found to be suitable for vapor and dust control, although substitution of a cleaning solution containing non-carcinogenic solvents for solutions containing carcinogens was recommended. PMID:10446485

Crouch, K G; Gressel, M G

1999-05-01

475

The control of press cleaning solvent vapors in a small lithographic printing establishment  

SciTech Connect

Small businesses frequently have inadequate in-house expertise to solve a variety of safety and health problems. The National Institute for Occupational Safety and Health (NIOSH) has therefore conducted a demonstration project in the commercial lithographic printing industry, which consists largely of small companies, in a effort to establish suitable control technology for airborne solvent vapors released primarily during press cleaning operations. These solvent vapors have a number of potential adverse health effects, including narcosis, kidney and liver damage, and cancer. Also, airborne anti-offset powder is a potential allergic sensitizer and cause of occupational asthma. As a means of controlling worker exposures to the vapors and dust, a local exhaust inlet was attached to the side of the press adjacent to the paper delivery point. Tempered outside air was introduced through ceiling outlets installed to make up for the exhausted air. Measurements of press operator exposure and area concentrations of solvent vapors and area concentration of anti-offset powder were made before and after installation of the new ventilation controls. Vapor concentrations were reduced by 73% for the press operators. Area concentrations of the vapors were reduced by 86% and dust concentration by 67%. The ventilation system was found to be suitable for vapor and dust control, although substitution of a cleaning solution containing non-carcinogenic solvents for solutions containing carcinogens was recommended.

Crouch, K.G.; Gressel, M.G. (National Inst. for Occupational Safety and Health, Cincinnati, OH (United States). Div. of Physical Sciences and Engineering)

1999-05-01

476

Hispidulin inhibits the release of glutamate in rat cerebrocortical nerve terminals.  

PubMed

Hispidulin, a naturally occurring flavone, has been reported to have an antiepileptic profile. An excessive release of glutamate is considered to be related to neuropathology of epilepsy. We investigated whether hispidulin affected endogenous glutamate release in rat cerebral cortex nerve terminals (synaptosomes) and explored the possible mechanism. Hispidulin inhibited the release of glutamate evoked by the K? channel blocker 4-aminopyridine (4-AP). The effects of hispidulin on the evoked glutamate release were prevented by the chelation of extracellular Ca? ions and the vesicular transporter inhibitor bafilomycin A1. However, the glutamate transporter inhibitor dl-threo-beta-benzyl-oxyaspartate did not have any effect on hispidulin action. Hispidulin reduced the depolarization-induced increase in cytosolic free Ca? concentration ([Ca?](C)), but did not alter 4-AP-mediated depolarization. Furthermore, the effect of hispidulin on evoked glutamate release was abolished by blocking the Ca(v)2.2 (N-type) and Ca(v)2.1 (P/Q-type) channels, but not by blocking ryanodine receptors or mitochondrial Na?/Ca? exchange. Mitogen-activated protein kinase kinase (MEK) inhibition also prevented the inhibitory effect of hispidulin on evoked glutamate release. Western blot analyses showed that hispidulin decreased the 4-AP-induced phosphorylation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) and synaptic vesicle-associated protein synapsin I, a major presynaptic substrate for ERK; this decrease was also blocked by the MEK inhibitor. Moreover, the inhibition of glutamate release by hispidulin was strongly attenuated in mice without synapsin I. These results show that hispidulin inhibits glutamate release from cortical synaptosomes in rats through the suppression of presynaptic voltage-dependent Ca? entry and ERK/synapsin I signaling pathway. PMID:22759588

Lin, Tzu-Yu; Lu, Cheng-Wei; Wang, Chia-Chuan; Lu, Jyh-Feng; Wang, Su-Jane

2012-09-01

477

Multiplicity among chemically peculiar stars. II. Cool magnetic Ap stars  

NASA Astrophysics Data System (ADS)

We present new orbits for sixteen Ap spectroscopic binaries, four of which might in fact be Am stars, and give their orbital elements. Four of them are SB2 systems: HD 5550, HD 22128, HD 56495 and HD 98088. The twelve other stars are: HD 9996, HD 12288, HD 40711, HD 54908, HD 65339, HD 73709, HD 105680, HD 138426, HD 184471, HD 188854, HD 200405 and HD 216533. Rough estimates of the individual masses of the components of HD 65339 (53 Cam) are given, combining our radial velocities with the results of speckle interferometry and with Hipparcos parallaxes. Considering the mass functions of 74 spectroscopic binaries from this work and from the literature, we conclude that the distribution of the mass ratio is the same for cool Ap stars and for normal G dwarfs. Therefore, the only differences between binaries with normal stars and those hosting an Ap star lie in the period distribution: except for the case of HD 200405, all orbital periods are longer than (or equal to) 3 days. A consequence of this peculiar distribution is a deficit of null eccentricities. There is no indication that the secondary has a special nature, like e.g. a white dwarf. Based on observations collected at the Observatoire de Haute-Provence (CNRS), France. Tables 1 to 3 are only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/394/151 Appendix B is only available in electronic form at http://www.edpsciences.org

Carrier, F.; North, P.; Udry, S.; Babel, J.

2002-10-01

478

The surface chemistry of the magnetic Ap star HD 147010  

NASA Astrophysics Data System (ADS)

HD 147010 is a hot (Teff = 13 000 K), large-field magnetic Ap star that is a member of the Upper Scorpius-Centaurus Association, which means it is a star with a well-defined age (log t = 6.70). We offer a comprehensive analysis of the magnetic field and surface chemistry of HD 147010 based on seven spectra obtained using CFHT's ESPaDOnS spectropolarimeter. This data set is sufficient to obtain a first-order model of the magnetic field and obtain the abundance distribution of He, O, Mg, Al, Si, Ca, Ti, Cr, Fe, Ni, Sr, La, Ce, Pr, Nd and Sm. The magnetic field model is a low-order multipole expansion based on the variations of the line of sight and surface magnetic fields with rotation. Spectral synthesis was carried out using ZEEMAN, a program which takes into account the influence of the magnetic field. A simple model of uniform abundance in each of two rings in the observed magnetic hemisphere with equal spans in colatitude was used. The new magnetic field measurements enabled us to re-analyse the rotation period of HD 147010, finding P = 3.9207 0.0003 d. The line of sight and surface magnetic field strengths vary from about -2000 to -5000 G and 11000 to 17000 G, respectively. Our analysis finds large overabundances of Fe-peak and rare-earth elements relative to the solar ratios. In all cases, where strong variability in surface chemistry is observed, abundances are higher near the magnetic equator as compared to the magnetic pole. HD 147010 appears to be an Ap star that is highly rich in rare-earth elements that are of the order of 105 times more abundant than in the Sun. This analysis adds to the growing number of hot Ap stars for which both the magnetic field and abundance distribution have been studied in detail.

Bailey, J. D.; Landstreet, J. D.

2013-06-01

479

The NuStart AP1000 Compact Control Room Implementation  

SciTech Connect

The nuclear power industry in the United States is experiencing renewed optimism that new nuclear power plants may be constructed in the foreseeable future. Presently a number of utilities in the U.S. are considering new nuclear plant construction. Among the reasons supporting the industry's optimism is the formation of the NuStart Energy Consortium. This consortium of leading energy companies, including Westinghouse Electric Company, is working with the U.S. Department of Energy to demonstrate and test the new licensing process for obtaining a Combined Construction and Operating License (COL) for an advanced light water reactor (ALWR). One ALWR design for which the NuStart Energy Consortium is pursuing a COL application is Westinghouse's passive AP1000. AP1000 received its Final Design Approval from the USNRC in the Fall of 2004 and was granted Design Certification by the NRC on December 30, 2005. A key element of the AP1000 COL application will be to close out Design Certification COL items related to the Main Control Room (MCR) and Human System Interface (HSI) design. During the AP1000 design certification licensing efforts, a control room and HSI design process was submitted and approved. Realizing that Instrumentation and Control (I and C) and HSI technology changes rapidly, Westinghouse chose to defer the detailed design of the control room and operator interfaces. This allows the latest technology to be used when a plant is actually going to be built. To fulfill the COL items for the upcoming application Westinghouse is performing a comprehensive Human Factors Engineering program in conjunction with development of an advanced set of HSI resources for a compact control room. This paper will discuss human factors program elements completed to date and the efforts currently in progress to complete the remaining elements. It will also describe the design progress for each HSI resource including a Wall Panel Information System, computerized procedure system, advanced alarm system and universal soft controls implemented as part of a distributed control system display set. Finally the paper will also discuss Westinghouse activities in cooperation with the Nuclear Energy Institute to define the expectations for a COL application in the HFE discipline corresponding to Chapter 18 of the Standard Review Plan. (authors)

Harmon, Daryl [Westinghouse Electric Company, Windsor, CT. (United States)

2006-07-01

480

24 APS STEP-UP Fellows Present Research at NIH  

NSDL National Science Digital Library

This article is on page 174-175 of The Physiologist, October 2012. The 24 APS NIDDK STEP-UP Fellows recently finished their eight-12-week laboratory research experience and traveled to Bethesda, MD to participate in the STEP-UP Research Symposium held at the DoubleTree Bethesda Hotel and at NIH. They were joined by the other 62 NIDDK STEP-UP fellows from the other four Coordinating Centers (Childrens Hospital, Los Angeles; Pennsylvania State Univ.; Univ. of Maryland,Baltimore County; and Virginia Commonwealth Univ.).

APS Education Office (American Physiological Society Education Office)

2012-10-01

481

Initial diagnostics commissioning results for the Advanced Photon Source (APS)  

SciTech Connect

Principal diagnostics systems have been installed and nearly all have been commissioned on the subsystems of the Advanced Photon Source (APS) facility. Data have been obtained on beam position, beam profile, current, beam loss rate, and synchrotron radiation monitors on both injector rings and most recently the main 7-GeV storage ring. Results for the 150- to 450-MeV electron beams in the accumulator ring, up to 7 GeV in the injector synchrotron, and 4.5 to 7 GeV in the SR will be presented.

Lumpkin, A.; Patterson, D.; Wang, X. [and others

1995-07-01

482

Non-dipolar magnetic fields in Ap stars  

E-print Network

An arbitrary initial magnetic field in an A star evolves into a stable equilibrium. Simulations are presented of the formation of non-axisymmetric equilibria consisting of twisted flux tubes meandering under the surface of the star, and analytic arguments are given relating the stability and form of these equilibria. These results may help to explain observations of Ap stars with very non-dipolar fields. This work is also applicable to other essentially non-convective stars such as white dwarfs and neutron stars.

Jonathan Braithwaite

2008-01-29

483

APS beamline standard components handbook, Version 1. 3  

SciTech Connect

This Handbook in its current version (1.3) contains descriptions, specifications, and preliminary engineering design drawings for many of the standard components. The design status and schedules have been provided wherever possible. In the near future, the APS plans to update engineering drawings of identified standard beamline components and complete the Handbook. The completed version of this Handbook will become available to both the CATs and potential vendors. Use of standard components should result in major cost reductions for CATs in the areas of beamline design and construction.

Hahn, U.; Shu, D.; Kuzay, T.M.

1993-02-01

484

76 FR 23755 - Release of Draft Risk and Exposure Assessments and Final Integrated Review Plan for the National...  

Federal Register 2010, 2011, 2012, 2013

...2060-AP38 Release of Draft Risk and Exposure Assessments...for the National Ambient Air Quality Standards for...and secondary ambient air quality standards...performed by the Clean Air Scientific Advisory Committee...risk assessment. The draft REA Plans and final...

2011-04-28

485

Mariner Mars 1971: Press kit  

NASA Technical Reports Server (NTRS)

The news release describes the 1971 launches of Mariner 8 and 9 which were to be the first attempt by NASA to orbit another planet, Mars. Described are: (1) mission capsule; (2) planetary missions; (3) aiming zones; (4) the spacecraft; (5) scientific experiments to be performed; (6) Atlas Centaur launch vehicle; (7) launch operations; (8) tracking and data system and mission operations; and (9) Mariner Mars 71 team and subcontractors.

Mittauer, R. T.

1971-01-01

486

In-flight quality evaluation of attitude measurements from STECE APS-01 star tracker  

NASA Astrophysics Data System (ADS)

The STECE satellite is a small satellite mission of China for space technology experiment and climate exploration. To test the in-flight performance of the CMOS Active Pixel Sensor (APS) based star trackers, the APS-01 star tracker has been loaded on the STECE satellite. The APS-01 star tracker payload delivers 1 Hz real time telemetry attitude data during its in-orbit experiment mission. These attitude data have been analyzed and evaluated down to the specification requirements like random noise, systematic bias and low frequency error in this paper. The systematic bias of APS-01, including precession-nutation, aberration and relative installation error, has been calibrated. An approach is proposed to analyze the attitude low frequency errors of APS-01. The results of the evaluation can contribute to a better understanding as well as further refinements of the CMOS APS based star trackers.

Lai, Yuwang; Liu, Junhong; Ding, Yonghe; Gu, Defeng; Yi, Dongyun

2014-09-01

487

Molecular determinants for the interaction between AMPA receptors and the clathrin adaptor complex AP-2  

PubMed Central

?-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-type glutamate receptors undergo constitutive and ligand-induced internalization that requires dynamin and the clathrin adaptor complex AP-2. We report here that an atypical basic motif within the cytoplasmic tails of AMPA-type glutamate receptors directly associates with ?2-adaptin by a mechanism similar to the recognition of the presynaptic vesicle protein synaptotagmin 1 by AP-2. A synaptotagmin 1-derived AP-2 binding peptide competes the interaction of the AMPA receptor subunit GluR2 with AP-2? and increases the number of surface active glutamate receptors in living neurons. Moreover, fusion of the GluR2-derived tail peptide with a synaptotagmin 1 truncation mutant restores clathrin/AP-2-dependent internalization of the chimeric reporter protein. These data suggest that common mechanisms regulate AP-2-dependent internalization of pre- and postsynaptic membrane proteins. PMID:17289840

Kastning, Kathrin; Kukhtina, Viktoria; Kittler, Josef T.; Chen, Guojun; Pechstein, Arndt; Enders, Sven; Lee, Sang Hyoung; Sheng, Morgan; Yan, Zhen; Haucke, Volker

2007-01-01

488

AUPress: A Comparison of an Open Access University Press with Traditional Presses  

ERIC Educational Resources Information Center

This study is a comparison of AUPress with three other traditional (non-open access) Canadian university presses. The analysis is based on the rankings that are correlated with book sales on Amazon.com and Amazon.ca. Statistical methods include the sampling of the sales ranking of randomly selected books from each press. The results of one-way

McGreal, Rory; Chen, Nian-Shing

2011-01-01

489

The high-energy ?-ray emission of AP Librae  

NASA Astrophysics Data System (ADS)

The ?-ray spectrum of the low-frequency-peaked BL Lac (LBL) object AP Librae is studied, following the discovery of very-high-energy (VHE; E> 100 GeV) ?-ray emission up to the TeV range by the H.E.S.S. experiment. This makes AP Librae one of the few VHE emitters of the LBL type. The measured spectrum yields a flux of (8.8 1.5stat 1.8sys) 10-12 cm-2 s-1 above 130 GeV and a spectral index of ? = 2.65 0.19stat 0.20sys. This study also makes use of Fermi-LAT observations in the high energy (HE, E> 100 MeV) range, providing the longest continuous light curve (5 years) ever published on this source. The source underwent a flaring event between MJD 56 306-56 376 in the HE range, with a flux increase of a factor of 3.5 in the 14 day bin light curve and no significant variation in spectral shape with respect to the low-flux state. While the H.E.S.S. and (low state) Fermi-LAT fluxes are in good agreement where they overlap, a spectral curvature between the steep VHE spectrum and the Fermi-LAT spectrum is observed. The maximum of the ?-ray emission in the spectral energy distribution is located below the GeV energy range.

H.E.S.S. Collaboration; Abramowski, A.; Aharonian, F.; Ait Benkhali, F.; Akhperjanian, A. G.; Angner, E.; Anton, G.; Backes, M.; Balenderan, S.; Balzer, A.; Barnacka, A.; Becherini, Y.; Becker Tjus, J.; Bernlhr, K.; Birsin, E.; Bissaldi, E.; Biteau, J.; Bttcher, M.; Boisson, C.; Bolmont, J.; Bordas, P.; Brucker, J.; Brun, F.; Brun, P.; Bulik, T.; Carrigan, S.; Casanova, S.; Chadwick, P. M.; Chalme-Calvet, R.; Chaves, R. C. G.; Cheesebrough, A.; Chrtien, M.; Colafrancesco, S.; Cologna, G.; Conrad, J.; Couturier, C.; Cui, Y.; Dalton, M.; Daniel, M. K.; Davids, I. D.; Degrange, B.; Deil, C.; deWilt, P.; Dickinson, H. J.; Djannati-Ata, A.; Domainko, W.; O'C. Drury, L.; Dubus, G.; Dutson, K.; Dyks, J.; Dyrda, M.; Edwards, T.; Egberts, K.; Eger, P.; Espigat, P.; Farnier, C.; Fegan, S.; Feinstein, F.; Fernandes, M. V.; Fernandez, D.; Fiasson, A.; Fontaine, G.; Frster, A.; Fling, M.; Gajdus, M.; Gallant, Y. A.; Garrigoux, T.; Giavitto, G.; Giebels, B.; Glicenstein, J. F.; Grondin, M.-H.; Grudzi?ska, M.; Hffner, S.; Hahn, J.; Harris, J.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hervet, O.; Hillert, A.; Hinton, J. A.; Hofmann, W.; Hofverberg, P.; Holler, M.; Horns, D.; Jacholkowska, A.; Jahn, C.; Jamrozy, M.; Janiak, M.; Jankowsky, F.; Jung, I.; Kastendieck, M. A.; Katarzy?ski, K.; Katz, U.; Kaufmann, S.; Khlifi, B.; Kieffer, M.; Klepser, S.; Klochkov, D.; Klu?niak, W.; Kneiske, T.; Kolitzus, D.; Komin, Nu.; Kosack, K.; Krakau, S.; Krayzel, F.; Krger, P. P.; Laffon, H.; Lamanna, G.; Lefaucheur, J.; Lemire, A.; Lemoine-Goumard, M.; Lenain, J.-P.; Lohse, T.; Lopatin, A.; Lu, C.-C.; Marandon, V.; Marcowith, A.; Marx, R.; Maurin, G.; Maxted, N.; Mayer, M.; McComb, T. J. L.; Mhault, J.; Meintjes, P. J.; Menzler, U.; Meyer, M.; Moderski, R.; Mohamed, M.; Moulin, E.; Murach, T.; Naumann, C. L.; de Naurois, M.; Niemiec, J.; Nolan, S. J.; Oakes, L.; Odaka, H.; Ohm, S.; de Oa Wilhelmi, E.; Opitz, B.; Ostrowski, M.; Oya, I.; Panter, M.; Parsons, R. D.; Paz Arribas, M.; Pekeur, N. W.; Pelletier, G.; Perez, J.; Petrucci, P.-O.; Peyaud, B.; Pita, S.; Poon, H.; Phlhofer, G.; Punch, M.; Quirrenbach, A.; Raab, S.; Raue, M.; Reichardt, I.; Reimer, A.; Reimer, O.; Renaud, M.; de los Reyes, R.; Rieger, F.; Rob, L.; Romoli, C.; Rosier-Lees, S.; Rowell, G.; Rudak, B.; Rulten, C. B.; Sahakian, V.; Sanchez, D. A.; Santangelo, A.; Schlickeiser, R.; Schssler, F.; Schulz, A.; Schwanke, U.; Schwarzburg, S.; Schwemmer, S.; Sol, H.; Spengler, G.; Spies, F.; Stawarz, ?.; Steenkamp, R.; Stegmann, C.; Stinzing, F.; Stycz, K.; Sushch, I.; Tavernet, J.-P.; Tavernier, T.; Taylor, A. M.; Terrier, R.; Tluczykont, M.; Trichard, C.; Valerius, K.; van Eldik, C.; van Soelen, B.; Vasileiadis, G.; Venter, C.; Viana, A.; Vincent, P.; Vlk, H. J.; Volpe, F.; Vorster, M.; Vuillaume, T.; Wagner, S. J.; Wagner, P.; Wagner, R. M.; Ward, M.; Weidinger, M.; Weitzel, Q.; White, R.; Wierzcholska, A.; Willmann, P.; Wrnlein, A.; Wouters, D.; Yang, R.; Zabalza, V.; Zacharias, M.; Zdziarski, A. A.; Zech, A.; Zechlin, H.-S.; Finke, J.; Fortin, P.; Horan, D.

2015-01-01

490

Designing an artificial pancreas architecture: the AP@home experience.  

PubMed

The latest achievements in sensor technologies for blood glucose level monitoring, pump miniaturization for insulin delivery, and the availability of portable computing devices are paving the way toward the artificial pancreas as a treatment for diabetes patients. This device encompasses a controller unit that oversees the administration of insulin micro-boluses and continuously drives the pump based on blood glucose readings acquired in real time. In order to foster the research on the artificial pancreas and prepare for its adoption as a therapy, the European Union in 2010 funded the AP@home project, following a series of efforts already ongoing in the USA. This paper, authored by members of the AP@home consortium, reports on the technical issues concerning the design and implementation of an architecture supporting the exploitation of an artificial pancreas platform. First a PC-based platform was developed by the authors to prove the effectiveness and reliability of the algorithms responsible for insulin administration. A mobile-based one was then adopted to improve the comfort for the patients. Both platforms were tested on real patients, and a description of the goals, the achievements, and the major shortcomings that emerged during those trials is also reported in the paper. PMID:25430423

Lanzola, Giordano; Toffanin, Chiara; Di Palma, Federico; Del Favero, Simone; Magni, Lalo; Bellazzi, Riccardo

2014-11-28

491

High-brightness beam diagnostics for the APS linac.  

SciTech Connect

The Advanced Photon Source (APS) injector includes an S-band linac with the capability to accelerate beams to 650 MeV. The linac has recently been upgraded with the installation of an rf thermionic gun in addition to the standard DC thermionic gun. The rf gun is predicted to have lower emittance (5{pi}mm mrad) and may be used to support the APS self-amplified spontaneous emission (SASE) experiments. The critical characterization of this gun's beam has begun with a beam diagnostics station at the end of the linac that can address beam transverse size, emittance, and bunch length (peak current). This station uses both an optical transition radiation (OTR) screen at 45{degree} to the beam direction and a Ce-doped YAG single crystal normal to the beam with a 45{degree} mirror behind it. The visible light images are detected by a Vicon CCD camera and a Hamamatsu C5680 synchroscan streak camera. Spatial resolution of about 30 {micro}m ({sigma}) and temporal resolution of 1 ps ({sigma}) have been demonstrated. Examples of rf gun beam characterization at 220 MeV are reported.

Lumpkin, A. H.

1999-04-20

492

Large break LOCA calculations for the AP600 design  

SciTech Connect

This paper presents the application of RELAP5 to the calculation of a Large Break (200% doubled-ended rupture) Loss-of-Colant-Accident (LBLOCA) at the reactor vessel inlet for the proposed Westinghouse AP600 design. A parametric calculation was also performed to determine effects of loss of a complete Emergency Core Cooling system (ECCS) train. These calculations were performed over the core blowdown, refill, and reflood phases of the LBLOCA and did not address long term cooling. RELAP5 was shown to be adequate for system response calculation over the period of interest. The passive safety systems were predicted to effectively mitigate the consequences of LBLOCAs; the calculations showed less severe thermal responses than for a current generation Pressurized Water Reactor (PWR) plant. The two primary differences between the AP600 design and a current generation plant that affect LBLOCA response are the lower core thermal power, which results in lower temperatures during the blowdown phase, and the long duration accumulator injection, which provides ample core inventory makeup for final quenching.

Fisher, J.E.

1992-01-01

493

Large break LOCA calculations for the AP600 design  

SciTech Connect

This paper presents the application of RELAP5 to the calculation of a Large Break (200% doubled-ended rupture) Loss-of-Colant-Accident (LBLOCA) at the reactor vessel inlet for the proposed Westinghouse AP600 design. A parametric calculation was also performed to determine effects of loss of a complete Emergency Core Cooling system (ECCS) train. These calculations were performed over the core blowdown, refill, and reflood phases of the LBLOCA and did not address long term cooling. RELAP5 was shown to be adequate for system response calculation over the period of interest. The passive safety systems were predicted to effectively mitigate the consequences of LBLOCAs; the calculations showed less severe thermal responses than for a current generation Pressurized Water Reactor (PWR) plant. The two primary differences between the AP600 design and a current generation plant that affect LBLOCA response are the lower core thermal power, which results in lower temperatures during the blowdown phase, and the long duration accumulator injection, which provides ample core inventory makeup for final quenching.

Fisher, J.E.

1992-08-01

494

Luteolin, a flavonoid, inhibits AP-1 activation by basophils  

SciTech Connect

Flavonoids including luteolin, apigenin, and fisetin are inhibitors of IL-4 synthesis and CD40 ligand expression by basophils. This study was done to search for compounds with greater inhibitory activity of IL-4 expression and to clarify the molecular mechanisms through which flavonoids inhibit their expression. Of the 37 flavonoids and related compounds examined, ayanin, luteolin, and apigenin were the strongest inhibitors of IL-4 production by purified basophils in response to anti-IgE antibody plus IL-3. Luteolin did not suppress Syk or Lyn phosphorylation in basophils, nor did suppress p54/46 SAPK/JNK, p38 MAPK, and p44/42 MAPK activation by a basophilic cell line, KU812 cells, stimulated with A23187 and PMA. However, luteolin did inhibit phosphorylation of c-Jun and DNA binding activity of AP-1 in nuclear lysates from stimulated KU812 cells. These results provide a fundamental structure of flavonoids for IL-4 inhibition and demonstrate a novel action of flavonoids that suppresses the activation of AP-1.

Hirano, Toru [Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Medical School, Osaka 565-0871 (Japan); Higa, Shinji [Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Medical School, Osaka 565-0871 (Japan); Arimitsu, Junsuke [Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Medical School, Osaka 565-0871 (Japan); Naka, Tetsuji [Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Medical School, Osaka 565-0871 (Japan); Ogata, Atsushi [Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Medical School, Osaka 565-0871 (Japan); Shima, Yoshihito [Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Medical School, Osaka 565-0871 (Japan); Fujimoto, Minoru [Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Medical School, Osaka 565-0871 (Japan); Yamadori, Tomoki [Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Medical School, Osaka 565-0871 (Japan); Ohkawara, Tomoharu; Kuwabara, Yusuke; Kawai, Mari [Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Medical School, Osaka 565-0871 (Japan); Matsuda, Hisashi; Yoshikawa, Masayuki [Kyoto Pharmaceutical University, Kyoto 607-8412 (Japan); Maezaki, Naoyoshi; Tanaka, Tetsuaki [Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871 (Japan); Kawase, Ichiro [Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Medical School, Osaka 565-0871 (Japan); Tanaka, Toshio [Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Medical School, Osaka 565-0871 (Japan)]. E-mail: ttanak@imed3.med.osaka-u.ac.jp

2006-02-03

495

APS Archive Collaborative: Building Tools for Library Partnerships  

NSDL National Science Digital Library

This is a poster from the 2008 NSDL annual meeting held in Washington, DC from September 30-October 2, 2008. The American Physiological Society (APS) Archive of Teaching Resources launched in April 2002 as a venue for colleague-to-colleague sharing. Since then, the Archive has grown into a collaborative digital library with resources catalogued by APS and three partners (HAPS, SDB, and NAHSEP). All partners used a common set of review and cataloging tools. In 2008, the Archive is being redesigned with new features for partner customization, expanded partnerships, and easier user access. New administration features allow partners to customize and handle their own submissions and reviews, including automatic email notifications. New submission features include partner-specific disciplines, keywords, special fields, and customized pages. New review features include partner-specific review criteria and forms. New search functions allow database searching via keyword (all text fields and vocabulary lists), advanced search (specific partner libraries and specific vocabularies), and browse (by disciplines, learning resource type and grade level). The personalized ?My Archive? retains previous functions (saving searches, saving resources to folders, sharing of folders) while also providing a listing of users? submissions and allowing users to track submissions through the review process. The new Archive will be open to Google searches; Login for the system will be required only for submissions and ?My Archive? features.

PhD Marsha L Matyas (American Physiological Society Education)

2009-09-29

496

Dynamic computer based procedures system for the AP1000 plant  

SciTech Connect

Westinghouse has designed, developed and implemented a data driven, software-based, computerized procedures system for the AP1000 plant that guides operators through plant operating procedures. It monitors plant data, processes the data and then, based on this processing, presents the status of the procedure steps to the operator. The system will be utilized for normal operating procedures, abnormal operating procedures and emergency operating procedures. Computerized (i.e., dynamic) procedures are critical to the design of the AP1000 compact control room and arguably provide the greatest benefit to operations compared to conventional control rooms. By replacing the paper medium, procedures can be fully integrated with the other human-machine interface resources. Computerized procedures allow the operator and computer to complement each other for more accurate and efficient procedural execution. In particular, an operator's mental workload can be reduced since information needed for procedure execution is integrated with the procedure steps. Computerized procedures provide a significant operational benefit by monitoring continuously applicable or parameter-dependent steps for their applicability, and then notifying the operator when they should be performed. This relieves operators of the burden of remembering this parallel information while actively performing other steps, and therefore improves the likelihood that the steps will be performed in an accurate, timely fashion. The computerized system is embodied in a user interface that supports diverse procedure views: a graphical flowchart view, a textual view and a dynamic logic view. (authors)

Lipner, M. H.; Mundy, R. A.; Franusich, M. D. [Westinghouse Electric Company, 4350 Northern Pike, Monroeville, PA 15146 (United States)

2006-07-01

497

Taking Stock: North American Pollutant Releases and Transfers 1995  

NSDL National Science Digital Library

This newly-online document from the Commission for Environmental Cooperation (CEC) describes "encouraging signs of a drop in pollution" from the major North American industries. The report, available in .pdf format, provides "a continental picture of pollutant release and transfer data (PRTD), based on information provided by the three governments from their domestic PRTD inventories." Users may download the following sections: Preface; Pollutant Releases and Transfers in North America; 1995 Canada and US Data Compared (Based on Matched Chemical/Industry Data Set); 1994 and 1995 Canada and US Data Compared (Based on Matched Chemical/Industry Data Set); Special Analyses; Border and Transborder Analyses; The Pulp and Paper Industry in Canada and the United States; Appendix A: A Comparison of Chemicals Listed under 1995 TRI, NPRI and RETC; and several press releases.

1998-01-01

498

Hot press molding process for pyramid-type glass optical multiplexer  

NASA Astrophysics Data System (ADS)

By developing a pyramid-shaped reflector, we were able to remove the optical filter that causes the decline in light efficiency in existing systems. A pyramid-type glass optical multiplexer (MUX) can be designed for beam coupling efficiency >60% in a combined module. The module was designed and optimized using CODE V, which utilizes nonlinear curve fitting numerical analysis. Based on optical design data, aspheric grinding paths were developed using ULG APS software. Tungsten carbide optical MUX mold cores were fabricated with an ultraprecision grinding machining device [ULG-100C(H3)] and optimum grinding machining of optical surface roughness (<60 nm, angle tolerance <0.05 deg). Pyramid-type optical MUX was fabricated using the hot press molding technique, and it was measured by using a contact geometry measuring device for reflection angle and angle uniformity. The measurement data were suitable for 490.05 deg, which was the design criterion. In addition, angle uniformity was >99.985%. A pyramid-type glass optical MUX molding technique was developed using an optical mold design, ultraprecision grinding machining technology, and a hot press molding system.

Ko, Myeong-Jin; Park, Soon-Sub

2014-12-01

499

Kiln for hot-pressing compacts in a continuous manner  

DOEpatents

The invention is directed to a hot pressing furnace or kiln which is capable of preheating, hot pressing, and cooling a plurality of articles in a sequential and continuous manner. The hot pressing furnace of the present invention comprises an elongated, horizontally disposed furnace capable of holding a plurality of displaceable pusher plates each supporting a die body loaded with refractory or ceramic material to be hot pressed. Each of these plates and the die body supported thereby is sequentially pushed through the preheating zone, a temperature stabilizing and a hot pressing zone, and a cooling zone so as to provide a continuous hot-pressing operation of a plurality of articles.

Reynolds, C.D Jr.

1983-08-08

500

Kiln for hot-pressing compacts in a continuous manner  

DOEpatents

The present invention is directed to a hot pressing furnace or kiln which is capable of preheating, hot pressing, and cooling a plurality of articles in a sequential and continuous manner. The hot pressing furnace of the present invention comprises an elongated, horizontally disposed furnace capable of holding a plurality of displaceable pusher plates each supporting a die body loaded with refractory or ceramic material to be hot pressed. Each of these plates and the die body supported thereby is sequentially pushed through the preheating zone, a temperature stabilizing and a hot pressing zone, and a cooling zone so as to provide a continuous hot-pressing operation of a plurality of articles.

Reynolds, Jr., Carl D. (Clinton, TN)

1985-01-01