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Sample records for array hybridization experiments

  1. Results of lower hybrid wave experiments using a dielectric loaded waveguide array antenna on TST-2

    NASA Astrophysics Data System (ADS)

    Wakatsuki, T.; Ejiri, A.; Shinya, T.; Takase, Y.; Furui, H.; Hiratsuka, J.; Imamura, K.; Inada, T.; Kakuda, H.; Kasahara, H.; Nagashima, Y.; Nakamura, K.; Nakanishi, A.; Oosako, T.; Saito, K.; Seki, T.; Shimpo, F.; Sonehara, M.; Togashi, H.; Tsuda, S.; Tsujii, N.; Yamaguchi, T.

    2014-02-01

    Lower hybrid current drive experiments were performed on the TST-2 spherical tokamak (R = 0.38 m, a = 0.25 m, Bt = 0.3 T, Ip = 0.1 MA). A waveguide array antenna consisting of four dielectric (alumina, ɛr = 10.0) loaded waveguides was used. The coupling characteristics were investigated over a wide range of input power (0.1 W - 40 kW). The reflection coefficient of this antenna increased when the input power exceeded approximately 1 kW. This result was compared with a numerical simulation based on the finite element method (FEM). The ponderomotive effect was calculated for the wave field calculated by COMSOL [1]. This calculation also showed variation of the reflection coefficient with the input power. Non-inductive plasma current start-up to 10 kA was demonstrated using 40 kW of lower hybrid wave (LHW) power. The current drive figure of merit (ηCD = IpneR/PRF) of this antenna was higher than that obtained using the combline antenna, which is designed to excite a travelling fast wave. The best current drive efficiency was obtained in the case in which the n∥ (= ck∥/ω) spectrum of the excited LHW was peaked around 9 and the toroidal field was higher than in previous experiments.

  2. Hybrid simulations of Z-Pinches in support of wire array implosion experiments at NTF.

    SciTech Connect

    Sotnikov, Vladimir Isaakovich; Oliver, Bryan Velten; Ivanov, Vladimir V.; LePell, Paul David; Fedin, Dmitry; Kantsyrev, Victor Leonidovich; Coverdale, Christine Anne; Travnicek, P.; Deeney, Christopher; Hellinger, P.; Jones, B.; Leboeuf, J. N.; Cowan, Thomas E.; Safronova, Alla S.

    2005-07-01

    Three-dimensional hybrid simulation of a plasma current-carrying column reveal two different regimes of sausage and kink instability development. In the first regime, with small Hall parameter, development of instabilities leads to the appearance of large-scale axial perturbations and eventually to bending of the plasma column. In the second regime, with a four-times-larger Hall parameter, small-scale perturbations dominate and no bending of the plasma column is observed. Simulation results are compared with laser probing experimental data obtained during wire array implosions on the Zebra pulse power generator at the Nevada Terawatt Facility.

  3. Telescope Array Experiment

    NASA Astrophysics Data System (ADS)

    Kawai, H.; Yoshida, S.; Yoshii, H.; Tanaka, K.; Cohen, F.; Fukushima, M.; Hayashida, N.; Hiyama, K.; Ikeda, D.; Kido, E.; Kondo, Y.; Nonaka, T.; Ohnishi, M.; Ohoka, H.; Ozawa, S.; Sagawa, H.; Sakurai, N.; Shibata, T.; Shimodaira, H.; Takeda, M.; Taketa, A.; Takita, M.; Tokuno, H.; Torii, R.; Udo, S.; Yamakawa, Y.; Fujii, H.; Matsuda, T.; Tanaka, M.; Yamaoka, H.; Hibino, K.; Benno, T.; Doura, K.; Chikawa, M.; Nakamura, T.; Teshima, M.; Kadota, K.; Uchihori, Y.; Hayashi, K.; Hayashi, Y.; Kawakami, S.; Matsuyama, T.; Minamino, M.; Ogio, S.; Ohshima, A.; Okuda, T.; Shimizu, N.; Tanaka, H.; Bergman, D. R.; Hughes, G.; Stratton, S.; Thomson, G. B.; Endo, A.; Inoue, N.; Kawana, S.; Wada, Y.; Kasahara, K.; Azuma, R.; Iguchi, T.; Kakimoto, F.; Machida, S.; Misumi, K.; Murano, Y.; Tameda, Y.; Tsunesada, Y.; Chiba, J.; Miyata, K.; Abu-Zayyad, T.; Belz, J. W.; Cady, R.; Cao, Z.; Huentemeyer, P.; Jui, C. C. H.; Martens, K.; Matthews, J. N.; Mostofa, M.; Smith, J. D.; Sokolsky, P.; Springer, R. W.; Thomas, J. R.; Thomas, S. B.; Wiencke, L. R.; Doyle, T.; Taylor, M. J.; Wickwar, V. B.; Wilkerson, T. D.; Hashimoto, K.; Honda, K.; Ikuta, K.; Ishii, T.; Kanbe, T.; Tomida, T.

    2008-01-01

    The TA observatory is a hybrid detector system consisting of both a surface detector array as well as a set of fluorescence detectors. The observatory will measure the energy spectrum, anisotropy and composition of ultra-high energy cosmic rays. The surface detectors are being deployed and the array should be complete by the end of February, 2007. We will soon be collecting hybrid data at the Telecope Array.

  4. Hybrid Arrays for Chemical Sensing

    NASA Astrophysics Data System (ADS)

    Kramer, Kirsten E.; Rose-Pehrsson, Susan L.; Johnson, Kevin J.; Minor, Christian P.

    In recent years, multisensory approaches to environment monitoring for chemical detection as well as other forms of situational awareness have become increasingly popular. A hybrid sensor is a multimodal system that incorporates several sensing elements and thus produces data that are multivariate in nature and may be significantly increased in complexity compared to data provided by single-sensor systems. Though a hybrid sensor is itself an array, hybrid sensors are often organized into more complex sensing systems through an assortment of network topologies. Part of the reason for the shift to hybrid sensors is due to advancements in sensor technology and computational power available for processing larger amounts of data. There is also ample evidence to support the claim that a multivariate analytical approach is generally superior to univariate measurements because it provides additional redundant and complementary information (Hall, D. L.; Linas, J., Eds., Handbook of Multisensor Data Fusion, CRC, Boca Raton, FL, 2001). However, the benefits of a multisensory approach are not automatically achieved. Interpretation of data from hybrid arrays of sensors requires the analyst to develop an application-specific methodology to optimally fuse the disparate sources of data generated by the hybrid array into useful information characterizing the sample or environment being observed. Consequently, multivariate data analysis techniques such as those employed in the field of chemometrics have become more important in analyzing sensor array data. Depending on the nature of the acquired data, a number of chemometric algorithms may prove useful in the analysis and interpretation of data from hybrid sensor arrays. It is important to note, however, that the challenges posed by the analysis of hybrid sensor array data are not unique to the field of chemical sensing. Applications in electrical and process engineering, remote sensing, medicine, and of course, artificial

  5. Space and power efficient hybrid counters array

    DOEpatents

    Gara, Alan G.; Salapura, Valentina

    2009-05-12

    A hybrid counter array device for counting events. The hybrid counter array includes a first counter portion comprising N counter devices, each counter device for receiving signals representing occurrences of events from an event source and providing a first count value corresponding to a lower order bits of the hybrid counter array. The hybrid counter array includes a second counter portion comprising a memory array device having N addressable memory locations in correspondence with the N counter devices, each addressable memory location for storing a second count value representing higher order bits of the hybrid counter array. A control device monitors each of the N counter devices of the first counter portion and initiates updating a value of a corresponding second count value stored at the corresponding addressable memory location in the second counter portion. Thus, a combination of the first and second count values provide an instantaneous measure of number of events received.

  6. Space and power efficient hybrid counters array

    DOEpatents

    Gara, Alan G.; Salapura, Valentina

    2010-03-30

    A hybrid counter array device for counting events. The hybrid counter array includes a first counter portion comprising N counter devices, each counter device for receiving signals representing occurrences of events from an event source and providing a first count value corresponding to a lower order bits of the hybrid counter array. The hybrid counter array includes a second counter portion comprising a memory array device having N addressable memory locations in correspondence with the N counter devices, each addressable memory location for storing a second count value representing higher order bits of the hybrid counter array. A control device monitors each of the N counter devices of the first counter portion and initiates updating a value of a corresponding second count value stored at the corresponding addressable memory location in the second counter portion. Thus, a combination of the first and second count values provide an instantaneous measure of number of events received.

  7. Performance measurements of hybrid PIN diode arrays

    SciTech Connect

    Shapiro, S.L. ); Arens, J.F.; Jernigan, J.G. . Space Sciences Lab.); Kramer, G. ); Collins, T.; Worley, S. ); Wilburn, C.D. ); Skubic, P. )

    1990-10-01

    We report the successful development of hybrid PIN diode arrays and a series of room-temperature measurements in a high-energy pion beam at FNAL. A PMOS VLSI 256 {times} 256 readout array having 30 {mu}m square pixels was indium-bump bonded to a mating PIN diode detector array. Preliminary measurements on the resulting hybrid show excellent signal-to-noise at room temperature. 3 refs., 5 figs.

  8. Solar array flight experiment

    NASA Technical Reports Server (NTRS)

    1986-01-01

    Emerging satellite designs require increasing amounts of electrical power to operate spacecraft instruments and to provide environments suitable for human habitation. In the past, electrical power was generated by covering rigid honeycomb panels with solar cells. This technology results in unacceptable weight and volume penalties when large amounts of power are required. To fill the need for large-area, lightweight solar arrays, a fabrication technique in which solar cells are attached to a copper printed circuit laminated to a plastic sheet was developed. The result is a flexible solar array with one-tenth the stowed volume and one-third the weight of comparably sized rigid arrays. An automated welding process developed to attack the cells to the printed circuit guarantees repeatable welds that are more tolerant of severe environments than conventional soldered connections. To demonstrate the flight readiness of this technology, the Solar Array Flight Experiment (SAFE) was developed and flown on the space shuttle Discovery in September 1984. The tests showed the modes and frequencies of the array to be very close to preflight predictions. Structural damping, however, was higher than anticipated. Electrical performance of the active solar panel was also tested. The flight performance and postflight data evaluation are described.

  9. Microheater Array Boiling Experiment

    NASA Technical Reports Server (NTRS)

    Kim, Jungho; McQuillen, John; Balombin, Joe

    2002-01-01

    By conducting pool boiling tests in microgravity, the effect of buoyancy on the overall boiling process and the relative magnitude of other phenomena can be assessed. Data from KC-135 and sounding rocket experiments indicate little effect of gravity on boiling heat transfer at wall superheats below 25 C, despite vast differences in bubble behavior between gravity levels. In microgravity, a large primary bubble, surrounded by smaller satellite bubbles, moved over the surface, occasionally causing nucleation. Once formed, the primary bubble size remained constant for a given superheat, indicating evaporation at the bubble base is balanced with condensation on the bubble cap. The primary bubble's size increased with wall superheat. Most heaters under the primary bubble had low heat transfer rates, suggesting liquid dryout. Strong Marangoni convection developed in microgravity, forming a 'jet' into the bulk liquid that forced the bubble onto the heater. An experiment is being designed for the. Microgravity Science Glovebox. This experiment uses two 96 element microheater arrays, 2.7 and 7.0 mm in size. These heaters are individually controlled to operate at a constant temperature, measuring local heat fluxes as a function of time and space. Most boiling experiments operate at constant wall heat flux with larger heaters, allowing only time and space-averaged measurements. Each heater is about the bubble departure size in normal gravity, but significantly smaller than the bubble departure size in reduced gravity.

  10. Hybrid Beamforming and Steering With Reconfigurable Arrays

    PubMed Central

    Hooi, Fong Ming; Thomenius, Kai E.; Fisher, Rayette; Carson, Paul L.

    2010-01-01

    Reconfigurable arrays offer an advantage over traditional ultrasound arrays because of their flexibility in channel selection. To improve ultrasound beamforming and coverage through beam steering, we propose a hybrid beamforming technique to elongate the depth of focus of transmit beams and a method of element selection that improves steering capabilities that take advantage of array reconfigurability using annular rings. A local minimization technique to optimize the hybrid aperture is discussed in this paper. The chosen hybrid apertures covering four focal zones result in improved range in depth of focus when compared with pure spherical beams via point spread functions (PSF) and lesion signal-tonoise ratio (LSNR) calculations. Improvements were statistically significant at focal depth extremes. Our method of beam steering utilizing a quantized phase delay selection to minimize delay errors indicated better performance by removing an artifact present with traditional ringed element selection. PMID:20529707

  11. Coulomb blockage of hybridization in two-dimensional DNA arrays

    NASA Astrophysics Data System (ADS)

    Vainrub, Arnold; Pettitt, B. Montgomery

    2002-10-01

    Experiments on DNA microarrays have revealed substantial differences in hybridization thermodynamics between DNA free in solution and surface tethered DNA. Here we develop a mean field model of the Coulomb effects in two-dimensional DNA arrays to understand the binding isotherms and thermal denaturation of the double helix. We find that the electrostatic repulsion of the assayed nucleic acid from the array of DNA probes dominates the binding thermodynamics, and thus causes the Coulomb blockage of the hybridization. The results explain, observed in DNA microarrays, the dramatic decrease of the hybridization efficiency and the thermal denaturation curve broadening as the probe surface density grows. We demonstrate application of the theory for evaluation and optimization of the sensitivity, specificity, and the dynamic range of DNA array devices.

  12. Performance measurements of hybrid PIN diode arrays

    SciTech Connect

    Jernigan, J.G.; Arens, J.F. . Space Sciences Lab.); Kramer, G. ); Collins, T.; Herring, J. ); Shapiro, S.L. ); Wilburn, C.D. )

    1990-05-01

    We report on the successful effort to develop hybrid PIN diode arrays and to demonstrate their potential as components of vertex detectors. Hybrid pixel arrays have been fabricated by the Hughes Aircraft Co. by bump bonding readout chips developed by Hughes to an array of PIN diodes manufactured by Micron Semiconductor Inc. These hybrid pixel arrays were constructed in two configurations. One array format having 10 {times} 64 pixels, each 120 {mu}m square, and the other format having 256 {times} 256 pixels, each 30 {mu}m square. In both cases, the thickness of the PIN diode layer is 300 {mu}m. Measurements of detector performance show that excellent position resolution can be achieved by interpolation. By determining the centroid of the charge cloud which spreads charge into a number of neighboring pixels, a spatial resolution of a few microns has been attained. The noise has been measured to be about 300 electrons (rms) at room temperature, as expected from KTC and dark current considerations, yielding a signal-to-noise ratio of about 100 for minimum ionizing particles. 4 refs., 13 figs.

  13. Short wavelength infrared hybrid focal plane arrays

    NASA Technical Reports Server (NTRS)

    Vural, K.; Blackwell, J. D.; Marin, E. C.; Edwall, D. D.; Rode, J. P.

    1983-01-01

    The employment of area focal plane arrays (FPA) has made it possible to obtain second generation infrared imaging systems with high resolution and sensitivity. The Short Wavelength Infrared (SWIR) region (1-2.5 microns) is of importance for imaging objects at high temperature and under conditions of reflected sunlight. The present investigation is concerned with electrooptical characterization results for 32 x 32 SWIR detector arrays and FPAs which are suitable for use in a prototype imaging spectrometer. The employed detector material is Hg(1-x)Cd(x)Te grown by liquid phase epitaxy on a CdTe transparent substrate. Attention is given to details of processing, the design of the detector array, the multiplexer, the fabrication of the hybrid FPA, and aspects of performance.

  14. Ideal and non-ideal MHD regimes of wire array implosion obtained in 3D hybrid simulations and observed during experiments at NTF.

    SciTech Connect

    Sotnikov, Vladimir Isaakovich; Fiala, V.; Oliver, Bryan Velten; Ivanov, Vladimir V.; LePell, Paul David; Fedin, Dmitry; Mehlhorn, Thomas Alan; Kantsyrev, Victor Leonidovich; Coverdale, Christine Anne; Travnicek, P.; Hellinger, P.; Deeney, Christopher; Jones, Brent Manley; Safronova, Alla S.; Leboeuf, J. N.; Cowan, Thomas E.

    2004-11-01

    Recent 3D hybrid simulation of a plasma current-carrying column revealed two regimes of sausage and kink instability development. In the first regime, with small Hall parameter, development of instabilities leads to appearance of large-scale axial perturbations and eventually to the bending of the plasma column. In the second regime, with five times larger Hall parameter, small-scale perturbations dominated and no bending of the plasma column was observed. Simulation results are compared to recent experimental data, including laser probing, x-ray spectroscopy and time-gated x-ray imaging during wire array implosions at NTF.

  15. Solar array flight dynamic experiment

    NASA Technical Reports Server (NTRS)

    Schock, R. W.

    1986-01-01

    The purpose of the Solar Array Flight Dynamic Experiment (SAFDE) is to demonstrate the feasibility of on-orbit measurement and ground processing of large space structures dynamic characteristics. Test definition or verification provides the dynamic characteristic accuracy required for control systems use. An illumination/measurement system was developed to fly on space shuttle flight STS-31D. The system was designed to dynamically evaluate a large solar array called the Solar Array Flight Experiment (SAFE) that had been scheduled for this flight. The SAFDE system consisted of a set of laser diode illuminators, retroreflective targets, an intelligent star tracker receiver and the associated equipment to power, condition, and record the results. In six tests on STS-41D, data was successfully acquired from 18 retroreflector targets and ground processed, post flight, to define the solar array's dynamic characteristic. The flight experiment proved the viability of on-orbit test definition of large space structures dynamic characteristics. Future large space structures controllability should be greatly enhanced by this capability.

  16. Solar array flight dynamic experiment

    NASA Technical Reports Server (NTRS)

    Schock, Richard W.

    1987-01-01

    The purpose of the Solar Array Flight Dynamic Experiment (SAFDE) is to demonstrate the feasibility of on-orbit measurement and ground processing of large space structures' dynamic characteristics. Test definition or verification provides the dynamic characteristic accuracy required for control systems use. An illumination/measurement system was developed to fly on space shuttle flight STS-41D. The system was designed to dynamically evaluate a large solar array called the Solar Array Flight Experiment (SAFE) that had been scheduled for this flight. The SAFDE system consisted of a set of laser diode illuminators, retroreflective targets, an intelligent star tracker receiver and the associated equipment to power, condition, and record the results. In six tests on STS-41D, data was successfully acquired from 18 retroreflector targets and ground processed, post flight, to define the solar array's dynamic characteristic. The flight experiment proved the viability of on-orbit test definition of large space structures dynamic characteristics. Future large space structures controllability should be greatly enhanced by this capability.

  17. Short Wavelength Infrared Hybrid Focal Plane Arrays

    NASA Astrophysics Data System (ADS)

    Vural, K.; Blackwell, J. D...; Marin, E. C.; Edwall, D. D...; Rode, J. P.

    1983-11-01

    Short wavelength (λc = 2.5 μm) 32 x 32 HgCdTe focal plane arrays have been fabricated for use in an Airborne Imaging Spectrometer (AIS) developed by the Jet Propulsion Labora-tory for NASA. An Imaging Spectrometer provides simultaneous imaging of several spectral bands for applications in the sensing and monitoring of earth resources. The detector material is HgCdTe grown on CdTe substrates using liquid phase epitaxy. Planar processing is used to make photovoltaic detectors on 68 um centers. The detector array is mated to a silicon charge coupled device multiplexer to make hybrid focal plane arrays. Results show high performance detectors with a mean RoA = 9.6 x 107 Ω --cm2 and IleakAge (-100 mV) = 0.037 pA at 120K and near zero background. The yield and uniformity are high. The ratio of the standard deviation of the dc responsivity to the mean is 3% for 98.5% of the pixels. The D1.0 = 1.3 x 1012 cm - âœ"fiz/W at a background of 1013 ph/cm2-s and 120K which is close to the background limited (BLIP) D* of 1.9 x 1012 cm- âœ"Hz/W.

  18. The hybrid energy spectrum of Telescope Array's Middle Drum Detector and surface array

    NASA Astrophysics Data System (ADS)

    Abbasi, R. U.; Abe, M.; Abu-Zayyad, T.; Allen, M. G.; Anderson, R.; Azuma, R.; Barcikowski, E.; Belz, J. W.; Bergman, D. R.; Blake, S. A.; Cady, R.; Chae, M. J.; Cheon, B. G.; Chiba, J.; Chikawa, M.; Cho, W. R.; Fujii, T.; Fukushima, M.; Goto, T.; Hanlon, W.; Hayashi, Y.; Hayashida, N.; Hibino, K.; Honda, K.; Ikeda, D.; Inoue, N.; Ishii, T.; Ishimori, R.; Ito, H.; Ivanov, D.; Jui, C. C. H.; Kadota, K.; Kakimoto, F.; Kalashev, O.; Kasahara, K.; Kawai, H.; Kawakami, S.; Kawana, S.; Kawata, K.; Kido, E.; Kim, H. B.; Kim, J. H.; Kim, J. H.; Kitamura, S.; Kitamura, Y.; Kuzmin, V.; Kwon, Y. J.; Lan, J.; Lim, S. I.; Lundquist, J. P.; Machida, K.; Martens, K.; Matsuda, T.; Matsuyama, T.; Matthews, J. N.; Minamino, M.; Mukai, K.; Myers, I.; Nagasawa, K.; Nagataki, S.; Nakamura, T.; Nonaka, T.; Nozato, A.; Ogio, S.; Ogura, J.; Ohnishi, M.; Ohoka, H.; Oki, K.; Okuda, T.; Ono, M.; Oshima, A.; Ozawa, S.; Park, I. H.; Pshirkov, M. S.; Rodriguez, D. C.; Rubtsov, G.; Ryu, D.; Sagawa, H.; Sakurai, N.; Sampson, A. L.; Scott, L. M.; Shah, P. D.; Shibata, F.; Shibata, T.; Shimodaira, H.; Shin, B. K.; Shin, H. S.; Smith, J. D.; Sokolsky, P.; Springer, R. W.; Stokes, B. T.; Stratton, S. R.; Stroman, T. A.; Suzawa, T.; Takamura, M.; Takeda, M.; Takeishi, R.; Taketa, A.; Takita, M.; Tameda, Y.; Tanaka, H.; Tanaka, K.; Tanaka, M.; Thomas, S. B.; Thomson, G. B.; Tinyakov, P.; Tkachev, I.; Tokuno, H.; Tomida, T.; Troitsky, S.; Tsunesada, Y.; Tsutsumi, K.; Uchihori, Y.; Udo, S.; Urban, F.; Vasiloff, G.; Wong, T.; Yamane, R.; Yamaoka, H.; Yamazaki, K.; Yang, J.; Yashiro, K.; Yoneda, Y.; Yoshida, S.; Yoshii, H.; Zollinger, R.; Zundel, Z.

    2015-08-01

    The Telescope Array experiment studies ultra high energy cosmic rays using a hybrid detector. Fluorescence telescopes measure the longitudinal development of the extensive air shower generated when a primary cosmic ray particle interacts with the atmosphere. Meanwhile, scintillator detectors measure the lateral distribution of secondary shower particles that hit the ground. The Middle Drum (MD) fluorescence telescope station consists of 14 telescopes from the High Resolution Fly's Eye (HiRes) experiment, providing a direct link back to the HiRes measurements. Using the scintillator detector data in conjunction with the telescope data improves the geometrical reconstruction of the showers significantly, and hence, provides a more accurate reconstruction of the energy of the primary particle. The Middle Drum hybrid spectrum is presented and compared to that measured by the Middle Drum station in monocular mode. Further, the hybrid data establishes a link between the Middle Drum data and the surface array. A comparison between the Middle Drum hybrid energy spectrum and scintillator Surface Detector (SD) spectrum is also shown.

  19. The Telescope Array experiment: status and prospects

    NASA Astrophysics Data System (ADS)

    Tokuno, H.; Abbasi, R. U.; Abu-Zayyad, T.; Azuma, R.; Belz, J. W.; Benno, T.; Bergman, D. R.; Blake, S. A.; Brusova, O.; Cady, R.; Cao, Z.; Cheon, B. G.; Chiba, J.; Chikawa, M.; Cho, I. S.; Chung, T.; Cohen, F.; Doura, K.; Doyle, T.; Endo, A.; Fujii, H.; Fukuda, T.; Fukushima, M.; Hayashi, Y.; Hayashi, K.; Hayashida, N.; Hibino, K.; Hiyama, K.; Honda, K.; Huentemeyer, P.; Hughes, G. A.; Iguchi, T.; Ikeda, D.; Ikuta, K.; Inoue, N.; Ishii, T.; Jui, C. C. H.; Kadota, K.; Kakimoto, F.; Kanbe, T.; Kasahara, K.; Kawai, H.; Kawakami, S.; Kawana, S.; Kido, E.; Kondo, Y.; Kwon, Y. J.; Machida, S.; Martens, K.; Matsuda, T.; Matsuyama, T.; Matthews, J. A. J.; Matthews, J. N.; Minamino, M.; Miyata, K.; Mostafa, M.; Murano, Y.; Nakamura, T.; Nam, S.; Nonaka, T.; Ogio, S.; Oh, S.; Ohnishi, M.; Ohoka, H.; Ohshima, A.; Okuda, T.; Ormes, J.; Ozawa, S.; Park, I. H.; Park, J. H.; Rodriguez, D.; Sagawa, H.; Sakurai, N.; Scott, L. M.; Shibata, T.; Shimizu, N.; Shimodaira, H.; Sinnis, G.; Smith, J. D.; Sokolsky, P.; Springer, R. W.; Stratton, S. R.; Suzuki, S.; Takeda, M.; Taketa, A.; Takita, M.; Tameda, Y.; Tanaka, K.; Tanaka, M.; Tanaka, H.; Taylor, M. J.; Teshima, M.; Thomas, J. R.; Thomas, S. B.; Thomson, G. B.; Tomida, T.; Torii, R.; Tsunesada, Y.; Uchihori, Y.; Udo, S.; Unno, Y.; Wada, Y.; Wickwar, V. B.; Wiencke, L. R.; Wilkerson, T. D.; Yamakawa, Y.; Yamaoka, H.; Yang, J.; Yoshida, S.; Yoshii, H.; Yun, Y. H.

    2008-07-01

    Telescope Array (TA) is a hybrid detector of a surface detector array and fluorescence telescopes. This hybrid detector will measure the energy spectrum, anisotropy and composition of ultra-high energy cosmic rays (UHECRs) to identify their origin. The almost construction of the detector has been completed in May 2007, and the detector is running under test and adjustments. The first hybrid observation with the full configuration is planned in beginning of 2008. In this paper the status and prospects of TA detector is described.

  20. Recent Results of the Telescope Array Experiment

    NASA Astrophysics Data System (ADS)

    Ivanov, Dmitri

    2015-04-01

    The Telescope Array (TA) is the largest cosmic ray experiment in the northern hemisphere and covers 10 PeV to 100 EeV range. TA is a hybrid detector that uses air fluorescence detectors combined with a ground array. TA consists of 507 plastic scintillation counters on a 1.2km square grid, overlooked by 3 fluorescence detector stations, and measures cosmic rays above 1 EeV. TA has collected 6.5 years of data. Results from the TA low energy extension (TALE), which sees cosmic rays down to 10 PeV, will also be shown. This contribution will consist of three parts. First, we will present the cosmic ray energy spectrum measured over 4 decades in energy. Next, we will discuss the latest results of the measurements of cosmic ray mass composition by the TA fluorescence detectors. Finally, we will show the latest results of the TA anisotropy measurements at the highest energies, where we have seen a concentration of events, called the ``hotspot,'' centered in the Ursa Major. For the Telescope Array Collaboration. Done...processed 1261 records...10:46:59 Beginning APS data extraction...10:47:48

  1. Computational Methods for the Analysis of Array Comparative Genomic Hybridization

    PubMed Central

    Chari, Raj; Lockwood, William W.; Lam, Wan L.

    2006-01-01

    Array comparative genomic hybridization (array CGH) is a technique for assaying the copy number status of cancer genomes. The widespread use of this technology has lead to a rapid accumulation of high throughput data, which in turn has prompted the development of computational strategies for the analysis of array CGH data. Here we explain the principles behind array image processing, data visualization and genomic profile analysis, review currently available software packages, and raise considerations for future software development. PMID:17992253

  2. Broadband-antireflective hybrid nanopillar array for photovoltaic application

    SciTech Connect

    Watanabe, Keiji Yamamoto, Jiro; Tsuchiya, Ryuta

    2015-08-28

    Subwavelength structures such as nanopillars, nanoholes, and nanodomes have recently attracted considerable attention as antireflective structures for solar cells. Recent studies on the optical property of nanopillar array revealed that the reflection minimum is related to the diameter, the pitch, and the height of nanopillars. Here, we investigate the “hybrid” nanopillar array, which is composed of different diameters of nanopillars. Finite differential time domain simulations revealed that the photogeneration in a hybrid nanopillar array is spatially heterogeneous: carriers are generated mainly in the narrower pillars for short-wavelength incident light and in the thicker pillars for long-wavelength light, respectively. Hybrid silicon nanopillar arrays fabricated by using electron beam lithography and dry etching show excellent broadband antireflection property. Hybrid nanopillar array is thus highly promising for next-generation antireflection for photovoltaic applications.

  3. a 40 GHZ Planar Array Antenna Using Hybrid Coupling

    NASA Astrophysics Data System (ADS)

    van der Wilt, F. P.; Strijbos, J. H. M.

    A new linearly polarized microstrip patch array is presented. The array is fed by using a combination of aperture coupling from a slotted waveguide and coplanar feeding using series-fed patch arrays. Advantages of this so-called hybrid coupling are easy control of the illumination of the array and a low feed loss, since the number of microstrip lines is kept to the minimum. In the paper we discuss how to design a Hybrid Coupled Planar Array (HCPA) antenna by using CAD modeling. Furthermore, we discuss several more features of the antenna type, such as its reasonable bandwidth, low cross-polarization and constructional simplicity. A 40 GHz 120-element HCPA antenna with a broadside beam has been built and tested. Experimental results for this array are presented.

  4. Utility of array comparative genomic hybridization in cytogenetic analysis.

    PubMed

    Singh, Rashmi R; Cheung, K-John J; Horsman, Douglas E

    2011-01-01

    Conventional comparative genomic hybridization (CGH), high-resolution oligonucleotide, and BAC array CGH have modernized the field of cytogenetics to enable access to unbalanced genomic aberrations such as whole or partial chromosomal gains and losses. The basic principle of array CGH involves hybridizing differentially labeled proband/test (e.g., tumor) and normal reference DNA on an array of oligonucleotide or BAC clones instead of normal metaphases as in conventional CGH. The sub-megabase resolution tiling BAC arrays are extremely useful for the analysis of acquired aberrations in cancer genomes. Array CGH can be extremely useful to identify the chromosomal makeup of marker and ring chromosomes, to define/delineate the precise location/bands involved in structural aberrations and the accurate localization of translocation breakpoints in both simple and complex karyotypes either alone or in combination with standard karyotype analysis. PMID:21431645

  5. High voltage solar array experiments

    NASA Technical Reports Server (NTRS)

    Kennerud, K. L.

    1974-01-01

    The interaction between the components of a high voltage solar array and a simulated space plasma is studied to obtain data for the design of a high voltage solar array capable of 15kW at 2 to 16kV. Testing was conducted in a vacuum chamber 1.5-m long by 1.5-m diameter having a plasma source which simulated the plasma conditions existing in earth orbit between 400 nautical miles and synchronous altitude. Test samples included solar array segments pinholes in insulation covering high voltage electrodes, and plain dielectric samples. Quantitative data are presented in the areas of plasma power losses, plasma and high voltage induced damage, and dielectric properties. Limitations of the investigation are described.

  6. SEP solar array shuttle flight experiment

    SciTech Connect

    Elms, R.V. Jr.; Young, L.E.; Hill, H.C.

    1981-01-01

    The design, fabrication, and ground verification testing project is underway at LMSC to support a SEP solar array shuttle flight experiment. A full-scale developmental SEP solar array wing is being refurbished for flight in an Orbiter scheduled for launch in early 1983. The experiment hardware design and the on-orbit test operations that are planned to meet the experiment objective are described. 1 ref.

  7. Arrays of probes for positional sequencing by hybridization

    DOEpatents

    Cantor, Charles R.; Prezetakiewiczr, Marek; Smith, Cassandra L.; Sano, Takeshi

    2008-01-15

    This invention is directed to methods and reagents useful for sequencing nucleic acid targets utilizing sequencing by hybridization technology comprising probes, arrays of probes and methods whereby sequence information is obtained rapidly and efficiently in discrete packages. That information can be used for the detection, identification, purification and complete or partial sequencing of a particular target nucleic acid. When coupled with a ligation step, these methods can be performed under a single set of hybridization conditions. The invention also relates to the replication of probe arrays and methods for making and replicating arrays of probes which are useful for the large scale manufacture of diagnostic aids used to screen biological samples for specific target sequences. Arrays created using PCR technology may comprise probes with 5'- and/or 3'-overhangs.

  8. Microelectrode arrays fabricated using a novel hybrid microfabrication method.

    PubMed

    Merlo, Mark W; Snyder, Russell L; Middlebrooks, John C; Bachman, Mark

    2012-02-01

    We present novel hybrid microfabrication methods for microelectrode arrays that combine microwire assembly, microelectromechanical systems (MEMS) manufacturing techniques and precision tool-based micromachining. This combination enables hybrid microfabrication to produce complex geometries and structures, increase material selection, and improve integration. A 32-channel shank microelectrode array was fabricated to highlight the hybrid microfabrication techniques. The electrode shank was 130 μm at its narrowest, had a 127 μm thickness and had iridium oxide electrode sites that were 25 μm in diameter with 150 μm spacing. Techniques used to fabricate this electrode include microassembly of insulated gold wires into a micromold, micromolding the microelectrode shank, post molding machining, sacrificial release of the microelectrode and electrodeposition of iridium oxide onto the microelectrode sites. Electrode site position accuracy was shown to have a standard deviation of less than 4 μm. Acute in vivo recordings with the 32-channel shank microelectrode array demonstrated comparable performance to that obtained with commercial microelectrode arrays. This new approach to microelectrode array fabrication will enable new microelectrodes, such as multi-sided arrays, drug eluding electrodes and biodegradable shanks. PMID:21979567

  9. Microelectrode arrays fabricated using a novel hybrid microfabrication method

    PubMed Central

    Merlo, Mark W.; Snyder, Russell L.; Middlebrooks, John C.; Bachman, Mark

    2011-01-01

    We present novel hybrid microfabrication methods for microelectrode arrays that combine microwire assembly, microelectromechanical systems (MEMS) manufacturing techniques and precision tool-based micromachining. This combination enables hybrid microfabrication to produce complex geometries and structures, increase material selection, and improve integration. A 32-channel shank microelectrode array was fabricated to highlight the hybrid microfabrication techniques. The electrode shank was 130 μm at its narrowest, had a 127 μm thickness and had iridium oxide electrode sites that were 25 μm in diameter with 150 μm spacing. Techniques used to fabricate this electrode include microassembly of insulated gold wires into a micromold, micromolding the microelectrode shank, post molding machining, sacrificial release of the microelectrode and electrodeposition of iridium oxide onto the microelectrode sites. Electrode site position accuracy was shown to have a standard deviation of less than 4 μm. Acute in vivo recordings with the 32-channel shank microelectrode array demonstrated comparable performance to that obtained with commercial microelectrode arrays . This new approach to microelectrode array fabrication will enable new microelectrodes, such as multi-sided arrays, drug eluding electrodes and biodegradable shanks. PMID:21979567

  10. Silicon PIN diode array hybrids for charged particle detection

    SciTech Connect

    Shapiro, S.L.; Dunwoodie, W.M.; Arens, J.F.; Jernigan, J.G.; Gaalema, S.

    1988-09-01

    We report on the design of silicon PIN diode array hybrids for use as charged particle detectors. A brief summary of the need for vertex detectors is presented. Circuitry, block diagrams and device specifications are included. 8 refs., 7 figs., 1 tab.

  11. Blocked impurity band hybrid infrared focal plane arrays for astronomy

    NASA Technical Reports Server (NTRS)

    Reynolds, D. B.; Seib, D. H.; Stetson, S. B.; Herter, T.; Rowlands, N.

    1989-01-01

    High-performance infrared hybrid focal plane arrays using 10- x 50-element Si:As blocked-impurity-band (BIB) detectors (cutoff wavelength = 28 microns) and matching switched MOSFET multiplexers have been developed and characterized for space astronomy. Use of impurity-band-conduction technology provides detectors which are nuclear-radiation-hard and free of the many anomalies associated with conventional silicon photoconductive detectors. Emphasis in the present work is on recent advances in detector material quality which have led to significantly improved detector and hybrid characteristics. Results demonstrating increased quantum efficiency (particularly at short-wavelength infrared), obtained by varying the BIB detector properties (infrared active layer thickness and arsenic doping profile), are summarized. Measured read noise and dark current for different temperatures are reported. The hybrid array performance achieved demonstrates that BIB detectors are well suited for use in astronomical instrumentation.

  12. Solar array experiments on the Sphinx satellite

    NASA Technical Reports Server (NTRS)

    Stevens, N. J.

    1973-01-01

    The Space Plasma, High Voltage Interaction Experiment (SPHINX) is the name given to an auxiliary payload satellite scheduled to be launched in January 1974. The principal experiments carried on this satellite are specifically designed to obtain the engineering data on the interaction of high voltage systems with the space plasma. The classes of experiments are solar array segments, insulators, insulators with pin holes and conductors. The satellite is also carrying experiments to obtain flight data on three new solar array configurations; the edge illuminated-multijunction cells, the Teflon encased cells and the violet cells.

  13. Compact collimated fiber optic array diagnostic for railgun plasma experiments

    SciTech Connect

    Tang, V; Solberg, J; Ferriera, T; Tully, L; Stephan, P

    2008-10-02

    We have developed and tested a compact collimated sixteen channel fiber optic array diagnostic for studying the light emission of railgun armature plasmas with {approx}mm spatial and sub-{micro}s temporal resolution. The design and operational details of the diagnostic are described. Plasma velocities, oscillation, and dimension data from the diagnostic for the Livermore Fixed Hybrid Armature experiment are presented and compared with 1-D simulations. The techniques and principles discussed allow the extension of the diagnostic to other railgun and related dense plasma experiments.

  14. Design, processing and testing of LSI arrays, hybrid microelectronics task

    NASA Technical Reports Server (NTRS)

    Himmel, R. P.; Stuhlbarg, S. M.; Ravetti, R. G.; Zulueta, P. J.; Rothrock, C. W.

    1979-01-01

    Mathematical cost models previously developed for hybrid microelectronic subsystems were refined and expanded. Rework terms related to substrate fabrication, nonrecurring developmental and manufacturing operations, and prototype production are included. Sample computer programs were written to demonstrate hybrid microelectric applications of these cost models. Computer programs were generated to calculate and analyze values for the total microelectronics costs. Large scale integrated (LST) chips utilizing tape chip carrier technology were studied. The feasibility of interconnecting arrays of LSU chips utilizing tape chip carrier and semiautomatic wire bonding technology was demonstrated.

  15. Recent results from the Telescope Array Experiment

    NASA Astrophysics Data System (ADS)

    Abbasi, Rasha; Telescope Array Collaboration

    2016-03-01

    The Telescope Array (TA) is the largest ultrahigh energy cosmic rays detector in the northern hemisphere. TA is a hybrid detector comprised of three air fluorescence stations and a large surface array consisting of 507 scintillator counters. Each of the three fluorescence stations, located at the periphery of the ground array, views 108 degrees in azimuth and up to 30 degrees in elevation. The surface detectors are arranged in a square grid of 1.2 km spacing, covering over 700 square kilometers. TA has collected more than seven years of data. In this talk, we will present some of the main results on the cosmic rays composition and energy spectrum obtained by TA and its low energy extension (TALE). Finally, we will present our results from the search for arrival direction anisotropy, including the observed large excess of events at the highest energies, seen in the region of the northern sky centered on Ursa Major. Based on the current results, the ``hot spot'' in particular, TA is pursuing the expansion of the surface array to four times its current size.

  16. Solar Array Module Plasma Interaction Experiment (SAMPIE)

    NASA Technical Reports Server (NTRS)

    Ferguson, Dale C.

    1992-01-01

    The objective of the Solar Array Module Plasma Interaction Experiment (SAMPIE) is to investigate, by means of a shuttle-based flight experiment and relevant ground-based testing, the arcing and current collection behavior of materials and geometries likely to be exposed to the LEO plasma on high-voltage space power systems, in order to minimize adverse environmental interactions. An overview of the SAMPIE program is presented in outline and graphical form.

  17. Hybrid Array of Gamma Ray Detectors (HAGRiD)

    NASA Astrophysics Data System (ADS)

    Smith, Karl; Grzywacz, R.; Jones, K. L.; Munoz, S.; Baugher, T.; Cizewski, J. A.; Ratkiewicz, A.; Pain, S. D.

    2015-10-01

    Transfer reactions and beta-decay studies are powerful tools to study nuclear structure and to provide insight into astrophysically important reactions that may be difficult to measure directly. Both types of studies are enhanced immensely by measuring a particle-gamma coincidence. For transfer reactions, gamma-ray measurements improve the resolution, aid in channel selection and lifetime measurements. To achieve these coincidences the Hybrid Array of Gamma Ray Detectors (HAGRiD) is being designed and constructed. This array would be coupled with the Oak Ridge Rutgers Barrel Array (ORRUBA) of silicon detectors, the Versatile Array of Neutron Detectors at Low Energy (VANDLE) and beta detection scintillators. Detector systems providing a particle-gamma coincidence have previously compromised the charged-particle angular resolution due to compact geometries used to increase the gamma efficiency. HAGRiD will be coupled with ORRUBA such that resolution is not sacrificed, requiring the new array to provide improved resolution and efficiency over NaI and increased portability and flexibility over germanium detectors; therefore, we have chosen to use LaBr3(Ce) crystals. We demonstrate the advantages of a coupled detector system and discuss the current status of the project.

  18. Underwater hybrid near-field acoustical holography based on the measurement of vector hydrophone array

    NASA Astrophysics Data System (ADS)

    Hu, Bo; Yang, Desen; Sun, Yu

    2010-06-01

    Hybrid near-field acoustical holography (NAH) is developed for reconstructing acoustic radiation from a cylindrical source in a complex underwater environment. In hybrid NAH, we combine statistically optimized near-field acoustical holography (SONAH) and broadband acoustical holography from intensity measurements (BAHIM) to reconstruct the underwater cylindrical source field. First, the BAHIM is utilized to regenerate as much acoustic pressures on the hologram surface as necessary, and then the acoustic pressures are taken as input to the formulation implemented numerically by SONAH. The main advantages of this technology are that the complex pressure on the hologram surface can be reconstructed without reference signal, and the measurement array can be smaller than the source, thus the practicability and efficiency of this technology are greatly enhanced. Numerical examples of a cylindrical source are demonstrated. Test results show that hybrid NAH can yield a more accurate reconstruction than conventional NAH. Then, an experiment has been carried out with a vector hydrophone array. The experimental results show the advantage of hybrid NAH in the reconstruction of an acoustic field and the feasibility of using a vector hydrophone array in an underwater NAH measurement, as well as the identification and localization of noise sources.

  19. Photovoltaic array space power plus diagnostics experiment

    NASA Technical Reports Server (NTRS)

    Burger, D. R.

    1990-01-01

    The objective is to summarize the five years of hardware development and fabrication represented by the Photovoltaic Array Space Power Plus Diagnostics (PASP Plus) Instrument. The original PASP Experiment requirements and background is presented along with the modifications which were requested to transform the PASP Experiment into the PASP Plus Instrument. The PASP Plus hardware and software is described. Test results for components and subsystems are given as well as final system tests. Also included are appendices which describe the major subsystems and present supporting documentation such as block diagrams, schematics, circuit board artwork, drawings, test procedures and test reports.

  20. Solar array flight experiment/dynamic augmentation experiment

    NASA Technical Reports Server (NTRS)

    Young, Leighton E.; Pack, Homer C., Jr.

    1987-01-01

    This report presents the objectives, design, testing, and data analyses of the Solar Array Flight Experiment/Dynamic Augmentation Experiment (SAFE/DAE) that was tested aboard Shuttle in September 1984. The SAFE was a lightweight, flat-fold array that employed a thin polyimide film (Kapton) as a substrate for the solar cells. Extension/retraction, dynamics, electrical and thermal tests, were performed. Of particular interest is the dynamic behavior of such a large lightweight structure in space. Three techniques for measuring and analyzing this behavior were employed. The methodology for performing these tests, gathering data, and data analyses are presented. The report shows that the SAFE solar array technology is ready for application and that new methods are available to assess the dynamics of large structures in space.

  1. Indium Hybridization of Large Format TES Bolometer Arrays to Readout Multiplexers for Far-Infrared Astronomy

    NASA Technical Reports Server (NTRS)

    Miller, Timothy M.; Costen, Nick; Allen, Christine

    2007-01-01

    This conference poster reviews the Indium hybridization of the large format TES bolometer arrays. We are developing a key technology to enable the next generation of detectors. That is the Hybridization of Large Format Arrays using Indium bonded detector arrays containing 32x40 elements which conforms to the NIST multiplexer readout architecture of 1135 micron pitch. We have fabricated and hybridized mechanical models with the detector chips bonded after being fully back-etched. The mechanical support consists of 30 micron walls between elements Demonstrated electrical continuity for each element. The goal is to hybridize fully functional array of TES detectors to NIST readout.

  2. Lower hybrid system design for the Tokamak physics experiment

    SciTech Connect

    Goranson, P.L.; Conner, D.L.; Swain, D.W.; Yugo, J.J.; Bernabei, S.; Greenough, N.

    1995-12-31

    The lower hybrid (LH) launcher configuration has been redesigned to integrate the functions of the vertical four-way power splitter and the front waveguide array (front array). This permits 256 waveguide channels to be fed by only 64 waveguides at the vacuum window interface. The resulting configuration is a more compact coupler, which incorporates the simplicity of a multijunction coupler while preserving the spectral flexibility of a conventional lower hybrid launcher. Other spin-offs of the redesign are reduction in thermal incompatibility between the front array and vacuum windows, improved maintainability, in situ vacuum window replacement, a reduced number of radio frequency (rf) connections, and a weight reduction of 7300 kg. There should be a significant cost reduction as well. Issues associated with the launcher design and fabrication have been addressed by a research and development program that includes brazing of the front array and testing of the power splitter configuration to confirm that phase errors due to reflections in the shorted splitter legs will not significantly impact the rf spectrum. The Conceptual Design Review requires that radiation levels at the torus radial port mounting flange and outer surface of the toroidal field coils should be sufficiently low to permit hands-on maintenance. Low activation materials and neutron shielding are incorporated in the launcher design to meet these requirements. The launcher is configured to couple 3 MW of steady state LH heating/LH current drive power at 3.7 GHz to the Tokamak Physics Experiment plasma.

  3. Hybrid-integrated prism array optoelectronic targeting system

    NASA Astrophysics Data System (ADS)

    Chang, C. C.; Chang, H. C.; Tang, L. C.; Young, W. K.; Wang, J. C.; Huang, K. L.

    2005-11-01

    This investigation proposes a cost-effective, compact, and robust optoelectronic targeting system for measuring ballistic impact velocity and the distribution of projectile motion. The major elements of this system are four photo-gates hybridized by compound one-dimensional prism array and analog/digital electronic components. The number of light sources and photodetectors used in a photo-gate was reduced to one pair of light source and photodetector. The average velocity and location of the projectile are determined according to the measured time intervals ( ˜10 -8 s) passing each pair. The system can accurately measure the velocity of a bullet as it leaves a gun barrel, as well as the velocity at specific points along the trajectory outside the firearm. Additionally, the system uses a widespread low-powered laser pointer as a light source. Compared with other optoelectronic targeting systems that use high-powered lasers, the proposed system is both economical and safe.

  4. Array-based comparative genomic hybridization (array CGH) for rapid prenatal diagnosis of cytogenetic abnormalities

    Technology Transfer Automated Retrieval System (TEKTRAN)

    We have shown in a prospective validation study that an array CGH test was highly accurate for rapid detection of chromosomal aneuploidies and deletions or duplications on fetal DNA samples in a clinical prenatal diagnostic setting. Here we present our updated "post-validation phase" experience with...

  5. Mutation Screening and Array Comparative Genomic Hybridization Using a 180K Oligonucleotide Array in VACTERL Association

    PubMed Central

    Winberg, Johanna; Gustavsson, Peter; Papadogiannakis, Nikos; Sahlin, Ellika; Bradley, Frideborg; Nordenskjöld, Edvard; Svensson, Pär-Johan; Annerén, Göran; Iwarsson, Erik; Nordgren, Ann; Nordenskjöld, Agneta

    2014-01-01

    In order to identify genetic causes of VACTERL association (V vertebral defects, A anorectal malformations, C cardiac defects, T tracheoesofageal fistula, E esophageal atresia, R renal anomalies, L limb deformities), we have collected DNA samples from 20 patients diagnosed with VACTERL or with a VACTERL-like phenotype as well as samples from 19 aborted fetal cases with VACTERL. To investigate the importance of gene dose alterations in the genetic etiology of VACTERL association we have performed a systematic analysis of this cohort using a 180K array comparative genomic hybridization (array-CGH) platform. In addition, to further clarify the significance of PCSK5, HOXD13 and CHD7 genes in the VACTERL phenotype, mutation screening has been performed. We identified pathogenic gene dose imbalances in two fetal cases; a hemizygous deletion of the FANCB gene and a (9;18)(p24;q12) unbalanced translocation. In addition, one pathogenic mutation in CHD7 was detected, while no apparent disease-causing mutations were found in HOXD13 or PCSK5. Our study shows that although large gene dose alterations do not seem to be a common cause in VACTERL association, array-CGH is still important in clinical diagnostics to identify disease cause in individual cases. PMID:24416387

  6. Design and Simulation of Hybridization Experiments

    Energy Science and Technology Software Center (ESTSC)

    1995-11-28

    DB EXP DESIGN is a suite of three UNIX shell-like programs, DWC which computes oligomer composition of DNA texts using directed acyclic word data structures; DWO, which simulates hybridization experiments; and DMI, which calculates the information contenet of individual probes, their mutual information content, and their joint information content through estimation of Markov trees.

  7. Report on Hybrid Rocket Cold Flow Experiments

    NASA Technical Reports Server (NTRS)

    Haapanen, Siina

    2004-01-01

    The discovery of paraffin based fuels has lead to renewed interest in hybrid rocket research. Experiments have shown that they burn 3-5 times faster than conventional hybrid fuels. High thrust level that would have required a multi-port design in the past can now be achieved with a single-port motor. While tests performed in Stanford and NASA Ames have demonstrated the paraffin hybrids to be a promising technology, one of the major challenges has been the relatively low efficiency. The c* efficiency has ranged between 80% and 90% in experiments conducted at the Ames Hybrid Combustion Facility (HCF). The test motor in these experiments had a 45 inch long fuel grain with the initial port diameter ranging between 3 and 5_inches. The c* efficiency is defined as the ratio of measured and theoretical characteristic velocities and is related to how completely the fuel and oxidizer are converted to combustion products. A low efficiency means that the reactants burn incompletely, and the reaction does not release the maximum possible amount of energy.

  8. Theory and experiment for infinite microstrip arrays

    NASA Astrophysics Data System (ADS)

    Wright, S. M.; Lo, Y. T.

    1985-01-01

    Microstrip antennas are well suited for use in large scanning arrays. To obtain greater bandwidth, it is useful to use thicker substrates, which can increase the effects of mutual coupling and lead to significant mismatch or blindness for certain scan angles. Using an infinite array formulation, the impedance of a single element in an infinite array environment was solved with the method of moments. Mutual coupling is built into the solution, and the presence of surface waves is accounted for by using the periodic Green's function for the grounded dielectric substrate. Blindness in arrays of microstrip dipoles on various substrates, both with and without radomes is demonstrated.

  9. High-resolution seismic array imaging based on an SEM-FK hybrid method

    NASA Astrophysics Data System (ADS)

    Tong, Ping; Chen, Chin-wu; Komatitsch, Dimitri; Basini, Piero; Liu, Qinya

    2014-04-01

    We demonstrate the feasibility of high-resolution seismic array imaging based on teleseismic recordings using full numerical wave simulations. We develop a hybrid method that interfaces a frequency-wavenumber (FK) calculation, which provides analytical solutions to 1-D layered background models with a spectral-element (SEM) numerical solver to calculate synthetic responses of local media to plane-wave incidence.This hybrid method accurately deals with local heterogeneities and discontinuity undulations, and represents an efficient tool for the forward modelling of teleseismic coda (including converted and scattered) waves. We benchmark the accuracy of the SEM-FK hybrid method against FK solutions for 1-D media. We then compute sensitivity kernels for teleseismic coda waves by interacting the forward teleseismic waves with an adjoint wavefield, produced by injecting coda waves as adjoint sources, based on adjoint techniques. These sensitivity kernels provide the basis for mapping variations in subsurface discontinuities, density and velocity structures through non-linear conjugate-gradient methods. We illustrate various synthetic imaging experiments, including discontinuity characterization, volumetric structural inversion for the crust or subduction zones. These tests show that using pre-conditioners based upon the scaled product of sensitivity kernels for different phases, combining finite-frequency traveltime and waveform inversion, and/or adopting hierarchical inversions from long- to short-period waveforms could reduce the non-linearity of the seismic inverse problem and speed up its convergence. The encouraging results of these synthetic examples suggest that inversion of teleseismic coda phases based on the SEM-FK hybrid method and adjoint techniques is a promising tool for structural imaging beneath dense seismic arrays.

  10. In-situ synthesis of photocatalytic CuAl2O4-Cu hybrid nanorod arrays.

    PubMed

    Ding, Dawei; Long, Mingce; Cai, Weimin; Wu, Yahui; Wu, Deyong; Chen, Chao

    2009-06-28

    Copper aluminate-copper hybrid nanorod arrays possessing superior visible-light driven photocatalytic properties were synthesized inside porous anodic aluminum oxide (AAO) under mild electrochemical conditions. PMID:19521617

  11. Array Comparative Genomic Hybridizations: Assessing the ability to recapture evolutionary relationships using an in silico approach

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Comparative Genomic Hybridization (CGH) with DNA microarrays has many biological applications including surveys of copy number changes in tumorigenesis, species detection and identification, and functional genomics studies among related organisms. Array CGH has also been used to infer phylogenetic r...

  12. Photovoltaic Array Space Power flight experiment plus diagnostics (PASP+) modules

    NASA Technical Reports Server (NTRS)

    Cooley, William T.; Adams, Steven F.; Reinhardt, Kitt C.; Piszczor, Michael F.

    1992-01-01

    The Photovoltaic Array Space Power Plus Diagnostics flight experiment (PASP+) subsumes twelve solar array modules which represent the state of the art in the space photovoltaic array industry. Each of the twelve modules individually feature specific photovoltaic technologies such as advanced semiconductor materials, multi-bandgap structures, lightweight array designs, advanced interconnect technologies, or concentrator array designs. This paper will describe each module in detail including the configuration, components, materials, anticipated on orbit performance, and some of the aspects of each array technology. The layout of each module and the photovoltaic cells or array cross section will be presented graphically. A discussion on the environmental constraints and materials selection will be included as well as a delineation of the differences between the modules and the baseline array configuration in its intended application.

  13. Landsat 7 Solar Array Testing Experiences

    NASA Technical Reports Server (NTRS)

    Helfrich, Daniel

    2000-01-01

    This paper covers the extensive Landsat 7 solar array flight qualification testing effort. Details of the mechanical design of the solar array and its retention/release system are presented. A testing chronology is provided beginning with the onset of problems encountered at the subsystem level and carrying through the third and final powered-spacecraft ground deployment test. Design fixes and other changes are explained in the same order as they became necessary to flight-qualify the array. Some interesting lessons learned are included along with key references.

  14. Addressable nanowell arrays formed using reversibly sealable hybrid elastomer-metal stencils.

    PubMed

    Pla-Roca, Mateu; Leulmi, Rym Feriel; Djambazian, Haig; Sundararajan, Saravanan; Juncker, David

    2010-05-01

    There are two major array formats used in life science research and biomedical analysis. The first is the microwell plate format with millimeter-sized wells each with microliter capacity addressed individually and repeatedly during experiments. The second is the microarray format with micrometer-sized spots that are patterned initially but not addressable individually thereafter. Here, we present an addressable nanoliter-well plate with micrometer sized wells that combines the advantages of the two array formats. The nanowells are formed by reversibly sealing a steel stencil featuring an array of micrometer-scale openings to an optically transparent substrate. The nanowells have a capacity of approximately 1 nL, are approximately 140 microm in diameter, and are arrayed at a density of 1600 wells cm(-2). A soft polymer is patterned photolithographically around each opening so as to form a microgasket for pressure sensitive, liquid tight, and reversible sealing to any type of smooth substrate, either hydrophilic or hydrophobic. The rigidity of the steel prevents the distortion that occurs in soft, all-polymeric stencils and permits accurate registration across the entire array, which in turn allows for repeated, individual addressing of wells using an inkjet spotter. The stencils are used to pattern cells, make protein microarrays, and create nanowells on surfaces to study reverse transfection by first spotting plasmids encoding fluorescent proteins into the wells, seeding cells, and monitoring the transfection of the cells in real time using time-lapse imaging. The hybrid elastomer-metal stencils (HEMSs) are versatile and useful for multiplexed analysis of drugs, biomolecules, and cells with microarray density. PMID:20377190

  15. A Bio-Hybrid Tactile Sensor Incorporating Living Artificial Skin and an Impedance Sensing Array

    PubMed Central

    Cheneler, David; Buselli, Elisa; Camboni, Domenico; Anthony, Carl; Grover, Liam; Adams, Michael John; Oddo, Calogero Maria

    2014-01-01

    The development of a bio-hybrid tactile sensor array that incorporates a skin analogue comprised of alginate encapsulated fibroblasts is described. The electrical properties are modulated by mechanical stress induced during contact, and changes are detected by a ten-channel dual-electrode impedance sensing array. By continuously monitoring the impedance of the sensor array at a fixed frequency, whilst normal and tangential loads are applied to the skin surface, transient mechanotransduction has been observed. The results demonstrate the effectiveness and feasibility of the preliminary prototype bio-hybrid tactile sensor. PMID:25615726

  16. Hybrid monopole/loop coil array for human head MR imaging at 7T

    PubMed Central

    Yan, Xinqiang; Wei, Long; Xue, Rong; Zhang, Xiaoliang

    2015-01-01

    The monopole coil and loop coil have orthogonal radiofrequency (RF) fields and thus are intrinsically decoupled electromagnetically if they are laid out appropriately. In this study, we proposed a hybrid monopole/loop technique which could combine the advantages of both loop arrays and monopole arrays. To investigate this technique, a hybrid RF coil array containing 4 monopole channels and 4 loop channels was developed for human head MR imaging at 7T. In vivo MR imaging and g-factor results using monopole-only channels, loop-only channels and all channels of the hybrid array were acquired and evaluated. Compared with the monopole-only and loop-only channels, the proposed hybrid array has higher SNR and better parallel imaging performance. Sufficient electromagnetic decoupling and diverse RF magnetic field (B1) distributions of monopole channels and loop channels may contribute to this performance improvement. From experimental results, the hybrid monopole/loop array has low g-factor and excellent SNR at both periphery and center of the brain, which is valuable for human head imaging at ultrahigh fields. PMID:26120252

  17. Direct fluorescence analysis of genetic polymorphisms by hybridization with oligonucleotide arrays on glass supports.

    PubMed Central

    Guo, Z; Guilfoyle, R A; Thiel, A J; Wang, R; Smith, L M

    1994-01-01

    A simple and rapid method for the analysis of genetic polymorphisms has been developed using allele-specific oligonucleotide arrays bound to glass supports. Allele-specific oligonucleotides are covalently immobilized on glass slides in arrays of 3 mm spots. Genomic DNA is amplified by PCR using one fluorescently tagged primer oligonucleotide and one biotinylated primer oligonucleotide. The two complementary DNA strands are separated, the fluorescently tagged strand is hybridized to the support-bound oligonucleotide array, and the hybridization pattern is detected by fluorescence scanning. Multiple polymorphisms present in the PCR product may be detected in parallel. The effect of spacer length, surface density and hybridization conditions were evaluated, as was the relative efficacy of hybridization with single or double-stranded PCR products. The utility of the method was demonstrated in the parallel analysis of 5 point mutations from exon 4 of the human tyrosinase gene. Images PMID:7816638

  18. Array-Based Comparative Genomic Hybridization for the Genomewide Detection of Submicroscopic Chromosomal Abnormalities

    PubMed Central

    Vissers, Lisenka E. L. M. ; de Vries, Bert B. A. ; Osoegawa, Kazutoyo ; Janssen, Irene M. ; Feuth, Ton ; Choy, Chik On ; Straatman, Huub ; van der Vliet, Walter ; Huys, Erik H. L. P. G. ; van Rijk, Anke ; Smeets, Dominique ; van Ravenswaaij-Arts, Conny M. A. ; Knoers, Nine V. ; van der Burgt, Ineke ; de Jong, Pieter J. ; Brunner, Han G. ; van Kessel, Ad Geurts ; Schoenmakers, Eric F. P. M. ; Veltman, Joris A. 

    2003-01-01

    Microdeletions and microduplications, not visible by routine chromosome analysis, are a major cause of human malformation and mental retardation. Novel high-resolution, whole-genome technologies can improve the diagnostic detection rate of these small chromosomal abnormalities. Array-based comparative genomic hybridization allows such a high-resolution screening by hybridizing differentially labeled test and reference DNAs to arrays consisting of thousands of genomic clones. In this study, we tested the diagnostic capacity of this technology using ∼3,500 flourescent in situ hybridization–verified clones selected to cover the genome with an average of 1 clone per megabase (Mb). The sensitivity and specificity of the technology were tested in normal-versus-normal control experiments and through the screening of patients with known microdeletion syndromes. Subsequently, a series of 20 cytogenetically normal patients with mental retardation and dysmorphisms suggestive of a chromosomal abnormality were analyzed. In this series, three microdeletions and two microduplications were identified and validated. Two of these genomic changes were identified also in one of the parents, indicating that these are large-scale genomic polymorphisms. Deletions and duplications as small as 1 Mb could be reliably detected by our approach. The percentage of false-positive results was reduced to a minimum by use of a dye-swap-replicate analysis, all but eliminating the need for laborious validation experiments and facilitating implementation in a routine diagnostic setting. This high-resolution assay will facilitate the identification of novel genes involved in human mental retardation and/or malformation syndromes and will provide insight into the flexibility and plasticity of the human genome. PMID:14628292

  19. Enabling Large Focal Plane Arrays Through Mosaic Hybridization

    NASA Technical Reports Server (NTRS)

    Miller, Timothy M.; Jhabvala, Christine A.; Leong, Edward; Costen, Nick P.; Sharp, Elmer; Adachi, Tomoko; Benford, Dominic J.

    2012-01-01

    We have demonstrated advances in mosaic hybridization that will enable very large format far-infrared detectors. Specifically we have produced electrical detector models via mosaic hybridization yielding superconducting circuit patbs by hybridizing separately fabricated sub-units onto a single detector unit. The detector model was made on a 100mm diameter wafer while four model readout quadrant chips were made from a separate 100mm wafer. The individually fabric.ted parts were hybridized using a Suss FCI50 flip chip bonder to assemble the detector-readout stack. Once all of the hybridized readouts were in place, a single, large and thick silicon substrate was placed on the stack and attached with permanent epoxy to provide strength and a Coefficient of Thermal Expansion match to the silicon components underneath. Wirebond pads on the readout chips connect circuits to warm readout electronics; and were used to validate the successful superconducting electrical interconnection of the model mosaic-hybrid detector. This demonstration is directly scalable to 150 mm diameter wafers, enabling pixel areas over ten times the area currently available.

  20. Enabling Large Focal Plane Arrays Through Mosaic Hybridization

    NASA Technical Reports Server (NTRS)

    Miller, Timothy M.; Jhabvala, Christine A.; Leong, Edward; Costen, Nicholas P.; Sharp, Elmer; Adachi, Tomoko; Benford, Dominic J.

    2012-01-01

    We have demonstrated advances in mosaic hybridization that will enable very large format far-infrared detectors. Specifically we have produced electrical detector models via mosaic hybridization yielding superconducting circuit paths by hybridizing separately fabricated sub-units onto a single detector unit. The detector model was made on a 100mm diameter wafer while four model readout quadrant chips were made from a separate 100mm wafer. The individually fabricated parts were hybridized using a flip-chip bonder to assemble the detector-readout stack. Once all of the hybridized readouts were in place, a single, large and thick silicon substrate was placed on the stack and attached with permanent epoxy to provide strength and a Coefficient of Thermal Expansion match to the silicon components underneath. Wirebond pads on the readout chips connect circuits to warm readout electronics; and were used to validate the successful superconducting electrical interconnection of the model mosaic-hybrid detector. This demonstration is directly scalable to 150 mm diameter wafers, enabling pixel areas over ten times the area currently available.

  1. Phased array antenna analysis using hybrid finite element methods

    NASA Astrophysics Data System (ADS)

    McGrath, Daniel T.

    1993-06-01

    This research in computational electromagnetics developed a new method for predicting the near-field mutual coupling effects in phased array antennas, using the finite element method (FEM) in combination with integral equations. Accurate feed modeling is accomplished by enforcing continuity between the FEM solution and an arbitrary number of wave guide models across a ground plane aperture. A periodic integral equation is imposed above the antenna's physical structure in order to enforce the radiation condition and to confine the analysis to an array unit cell. The electric field is expanded in terms of vector finite elements, and Galerkin's method is used to write the problem as a matrix equation. A general-purpose computer code was developed and validated by comparing its results to published data for several array types. Its versatility was demonstrated with predictions of the scanning properties of arrays of printed dipoles and printed flared notches.

  2. Lower hybrid rf heating experiments in the MIT Alcator A, C and Versator II tokamaks

    SciTech Connect

    Porkolab, M.; Schuss, J.; Takase, Y.; Chen, K.I.; Knowlton, S.; Luckhardt, S.; McDermott, S.

    1980-01-01

    Experimental results on lower hybrid heating in the Alcator A and the Versator II tokamaks with power levels up to 90 kW are presented. In Alcator A a double waveguide grill, and in Versator II a 4 waveguide grill with arbitrary phasing are used. Also, a 6 waveguide grill experiment in Versator II is described which launches a travelling wave aimed at driving toroidal currents. The forthcoming lower hybrid heating experiment in Alcator C, utilizing four 4 x 4 waveguide arrays with power levels up to 4 MW, is also described.

  3. Hybridization process for back-illuminated silicon Geiger-mode avalanche photodiode arrays

    NASA Astrophysics Data System (ADS)

    Schuette, Daniel R.; Westhoff, Richard C.; Loomis, Andrew H.; Young, Douglas J.; Ciampi, Joseph S.; Aull, Brian F.; Reich, Robert K.

    2010-04-01

    We present a unique hybridization process that permits high-performance back-illuminated silicon Geiger-mode avalanche photodiodes (GM-APDs) to be bonded to custom CMOS readout integrated circuits (ROICs) - a hybridization approach that enables independent optimization of the GM-APD arrays and the ROICs. The process includes oxide bonding of silicon GM-APD arrays to a transparent support substrate followed by indium bump bonding of this layer to a signal-processing ROIC. This hybrid detector approach can be used to fabricate imagers with high-fill-factor pixels and enhanced quantum efficiency in the near infrared as well as large-pixel-count, small-pixel-pitch arrays with pixel-level signal processing. In addition, the oxide bonding is compatible with high-temperature processing steps that can be used to lower dark current and improve optical response in the ultraviolet.

  4. PASP, a high voltage array/plasma interaction experiment. [Photovoltaic Array Space Power

    NASA Technical Reports Server (NTRS)

    Burger, Dale R.

    1991-01-01

    The author discusses the photovoltaic array space power (PASP) experiment, which is designed to obtain data on the interaction between high-voltage photovoltaic arrays and the polar, low-earth plasma environment. Up to six small test arrays (three each of planar and concentrator designs) can be voltage biased over a range of +/- 500 V. During the bias voltage sequence, the array current leakage is measured and array arc events are monitored. If any arcing occurs the arc characteristics will be measured by a transient pulse monitor. An emitter is included to allow voltage bias to be applied to a plasma-charged or uncharged spacecraft. Similarly, the frames of the concentrator arrays can be left floating or can be tied to the negative array terminal. An environmental data scan is made before each bias voltage sequence. This scan collects information on the plasma, array-current-versus-voltage curves, and neutral particle partial pressure. The requirement for high voltages created problems which were met by circuit isolation and logical fault protection.

  5. Solar array shuttle flight experiment - hardware development and testing

    SciTech Connect

    Elms, R.V.; Hill, H.C.; Young, L.E.

    1982-09-01

    This paper reports on the fabrication and ground testing of a large area, light-weight, flexible substrate developmental solar array wing that has been built for NASA-MSFC (Contract NAS8-31352) and of the supporting structure and data acquisition system (DAS) which, with the wing will be flown in the shuttle as an experiment in 1984. The experiment will verify the dynamics, thermodynamic, and electrical performance predictions of the array wing and will demonstrate the structural capability of the array wing for Orbiter launch and re-entry environments. The accomodation of the Shuttle payload requirements has resulted in several array wing and operation modifications since the ground demonstration of the array wing in the technology development program. The experiment hardware verification program was designed to minimize costs and risk of experiment performance degradation while maintaining shuttle and crew safety. The previous full-scale wing hardware tests included an extension mast water table test and wing testing for random vibration, thermal vacuum, and acoustic environments. The results of these tests were used to define wing design modifications and to scope the test program for the experiment hardware. The experiment hardware acceptance test program will be completed in October 1982.

  6. Ka-band MMIC arrays for ACTS Aero Terminal Experiment

    NASA Technical Reports Server (NTRS)

    Raquet, C.; Zakrajsek, R.; Lee, R.; Turtle, J.

    1992-01-01

    An antenna system consisting of three experimental Ka-band active arrays using GaAs MMIC devices at each radiating element for electronic beam steering and distributed power amplification is presented. The MMIC arrays are to be demonstrated in the ACTS Aeronautical Terminal Experiment, planned for early 1994. The experiment is outlined, with emphasis on a description of the antenna system. Attention is given to the way in which proof-of-concept MMIC arrays featuring three different state-of-the-art approaches to Ka-band MMIC insertion are being incorporated into an experimental aircraft terminal for the demonstration of an aircraft-to-satellite link, providing a basis for follow-on MMIC array development.

  7. 256 x 256 hybrid HgCdTe infrared focal plane arrays

    NASA Astrophysics Data System (ADS)

    Bailey, Robert B.; Kozlowski, Lester J.; Chen, Jenkon; Bui, Duc Q.; Vural, Kadri

    1991-05-01

    Hybrid HgCdTe 256 x 256 focal plane arrays have been developed to meet the sensitivity, resolution, and field-of-view requirements of high-performance medium-wavelength infrared (MWIR) imaging systems. The detector arrays for these hybrids are fabricated on substrates that reduce or eliminate the thermal expansion mismatch to the silicon readout circuit. The readouts are foundry-processed CMOS switched-FET circuits that have charge capacities greater than 107 electrons and a single video output capable of 10-MHz data rates. The high quantum efficiency, tunable absorption wavelength, and broad operating temperature range of these large HgCdTe staring focal plane arrays give them significant advantages over competing sensors. The mature Producible Alternative to CdTe for Epitaxy-1 (PACE-1) technology, using sapphire detector substrates, has demonstrated 256 x 256 MWIR arrays with mean laboratory noise equivalent temperature difference (NETO) of 9 mK for a 4.9-micron cutoff wavelength, 40-micron pixel size, and 80-K operating temperature. RMS detector response nonuniformities are less than 4 percent, and pixel yields are greater than 99 percent. The newly developed PACE-3 process uses silicon for the detector substrate to eliminate completely the thermal mismatch with the silicon readout circuit. It has the potential for similar performance in even larger array sizes. A 640 x 480 hybrid array is under development.

  8. Application of Array-Based Comparative Genomic Hybridization to Pediatric Neurologic Diseases

    PubMed Central

    Byeon, Jung Hye; Shin, Eunsim; Kim, Gun-Ha; Lee, Kyungok; Hong, Young Sook; Lee, Joo Won

    2014-01-01

    Purpose Array comparative genomic hybridization (array-CGH) is a technique used to analyze quantitative increase or decrease of chromosomes by competitive DNA hybridization of patients and controls. This study aimed to evaluate the benefits and yield of array-CGH in comparison with conventional karyotyping in pediatric neurology patients. Materials and Methods We included 87 patients from the pediatric neurology clinic with at least one of the following features: developmental delay, mental retardation, dysmorphic face, or epilepsy. DNA extracted from patients and controls was hybridized on the Roche NimbleGen 135K oligonucleotide array and compared with G-band karyotyping. The results were analyzed with findings reported in recent publications and internet databases. Results Chromosome imbalances, including 9 cases detected also by G-band karyotyping, were found in 28 patients (32.2%), and at least 19 of them seemed to be causally related to the abnormal phenotypes. Regarding each clinical symptom, 26.2% of 42 developmental delay patients, 44.4% of 18 mental retardation patients, 42.9% of 28 dysmorphic face patients, and 34.6% of 26 epilepsy patients showed abnormal array results. Conclusion Although there were relatively small number of tests in patients with pediatric neurologic disease, this study demonstrated that array-CGH is a very useful tool for clinical diagnosis of unknown genome abnormalities performed in pediatric neurology clinics. PMID:24339284

  9. Response Surface Model Building Using Orthogonal Arrays for Computer Experiments

    NASA Technical Reports Server (NTRS)

    Unal, Resit; Braun, Robert D.; Moore, Arlene A.; Lepsch, Roger A.

    1997-01-01

    This study investigates response surface methods for computer experiments and discusses some of the approaches available. Orthogonal arrays constructed for computer experiments are studied and an example application to a technology selection and optimization study for a reusable launch vehicle is presented.

  10. Conceptual design of a hybrid Ge:Ga detector array

    NASA Technical Reports Server (NTRS)

    Parry, C. M.

    1984-01-01

    For potential applications in space infrared astronomy missions such as the Space Infrared Telescope Facility and the Large Deployable Reflector, integrated arrays of long-wavelength detectors are desired. The results of a feasibility study which developed a design for applying integrated array techniques to a long-wavelength (gallium-doped germanium) material to achieve spectral coverage between 30 and 200 microns are presented. An approach which builds up a two-dimensional array by stacking linear detector modules is presented. The spectral response of the Ge:Ga detectors is extended to 200 microns by application of uniaxial stress to the stack of modules. The detectors are assembled with 1 mm spacing between the elements. Multiplexed readout of each module is accomplished with integration sampling of a metal-oxide-semiconductor (MOS) switch chip. Aspects of the overall design, including the anticipated level of particle effects on the array in the space environment, a transparent electrode design for 200 microns response, estimates of optical crosstalk, and mechanical stress design calculations are included.

  11. Surface plasmon enhanced quantum transport in a hybrid metal nanoparticle array

    NASA Astrophysics Data System (ADS)

    Sun, Lin; Nan, Yali; Xu, Shang; Zhang, Sishi; Han, Min

    2014-07-01

    Hybrid Pd-Ag nanoparticle arrays composed of randomly distributed Pd nanoparticles in dense packing and a small number of dispersed Ag nanoparticles were fabricated with controlled coverage. Photo-enhanced conductance was observed in the nanoparticle arrays. Largest enhancement, which can be higher than 20 folds, was obtained with 450 nm light illumination. This wavelength was found to correlate with the surface plasmon resonance of the Ag nanoparticles. Electron transport measurements showed there were significant Coulomb blockade in the nanoparticle arrays and the blockade could be overcome with the surface plasmon enhanced local field of Ag nanoparticles induced by light illumination.

  12. Indium Hybridization of Large Format TES Bolometer Arrays to Readout Multiplexers for Far-Infrared Astronomy

    NASA Technical Reports Server (NTRS)

    Miller, Timothy M.; Costen, Nick; Allen, Christine

    2007-01-01

    The advance of new detector technologies combined with enhanced fabrication methods has resulted in an increase in development of large format arrays. The next generation of scientific instruments will utilize detectors containing hundreds to thousands of elements providing a more efficient means to conduct large area sky surveys. Some notable detectors include a 32x32 x-ray microcalorimeter for Constellation-X, an infrared bolometer called SAFIRE to fly on the airborne observatory SOFIA, and the sub-millimeter bolometer SCUBA-2 to be deployed at the JCMT which will use more than 10,000 elements for two colors, each color using four 32x40 arrays. Of these detectors, SCUBA-2 is farthest along in development and uses indium hybridization to multiplexers for readout of the large number of elements, a technology that will be required to enable the next generation of large format arrays. Our current efforts in working toward large format arrays have produced GISMO, the Goddard IRAM Superconducting 2-Millimeter observer. GISMO is a far infrared instrument to be field tested later this year at the IRAM 30 meter telescope in Spain. GISMO utilizes transition edge sensor (TES) technology in an 8x16 filled array format that allows for typical fan-out wiring and wire-bonding to four 1x32 NIST multiplexers. GISMO'S electrical wiring is routed along the tops of 30 micron walls which also serve as the mechanical framework for the array. This architecture works well for the 128 element array, but is approaching the limit for routing the necessary wires along the surface while maintaining a high fill factor. Larger format arrays will benefit greatly from making electrical connections through the wafer to the backside, where they can be hybridized to a read-out substrate tailored to handling the wiring scheme. The next generation array we are developing is a 32x40 element array on a pitch of 1135 microns that conforms to the NIST multiplexer, already developed for the SCUBA-2

  13. Design, processing and testing of LSI arrays: Hybrid microelectronics task

    NASA Technical Reports Server (NTRS)

    Himmel, R. P.; Stuhlbarg, S. M.; Ravetti, R. G.; Zulueta, P. J.

    1979-01-01

    Mathematical cost factors were generated for both hybrid microcircuit and printed wiring board packaging methods. A mathematical cost model was created for analysis of microcircuit fabrication costs. The costing factors were refined and reduced to formulae for computerization. Efficient methods were investigated for low cost packaging of LSI devices as a function of density and reliability. Technical problem areas such as wafer bumping, inner/outer leading bonding, testing on tape, and tape processing, were investigated.

  14. Graphene/carbon nanotube hybrid-based transparent 2D optical array.

    PubMed

    Kim, Un Jeong; Lee, Il Ha; Bae, Jung Jun; Lee, Sangjin; Han, Gang Hee; Chae, Seung Jin; Güneş, Fethullah; Choi, Jun Hee; Baik, Chan Wook; Kim, Sun Il; Kim, Jong Min; Lee, Young Hee

    2011-09-01

    Graphene/carbon nanotube (CNT) hybrid structures are fabricated for use as optical arrays. Vertically aligned CNTs are directly synthesized on a graphene/quartz substrate using plasma-enhanced chemical vapor deposition (PECVD). Graphene preserves the transparency and resistance during CNT growth. Highly aligned single-walled CNTs show a better performance for the diffraction intensity. PMID:21769950

  15. Hybrid optoacoustic tomography and pulse-echo ultrasonography using concave arrays.

    PubMed

    Merčep, Elena; Jeng, Gency; Morscher, Stefan; Li, Pai-Chi; Razansky, Daniel

    2015-09-01

    Implementation of hybrid imaging using optoacoustic tomography (OAT) and ultrasound (US) brings together the important advantages and complementary features of both methods. However, the fundamentally different physical contrast mechanisms of the two modalities may impose significant difficulties in the optimal tomographic data acquisition and image formation strategies. We investigate the applicability of the commonly applied imaging geometries for acquisition and reconstruction of hybrid optoacoustic tomography and pulse-echo ultrasound (OPUS) images. Optimization of the ultrasound image formation strategy using concave array geometry was implemented using a synthetic aperture method combined with spatial compounding. Experimental validation was performed using a custom-made multiplexer unit executing switching between the two modalities employing the same transducer array. A variety of array probes with different angular coverages were subsequently tested, including arrays for clinical hand-held imaging as well as stationary arrays for tomographic small animal imaging. The results demonstrate that acquisition of OAT data by mere addition of an illumination source to the common US linear array geometry may result in significant limited-view artifacts and overall loss of image quality. On the other hand, unsatisfactory US image quality is achieved with tomographic arrays solely optimized for OAT image acquisition without considering the optimal transmit-receive beamforming parameters. Optimal selection of the array pitch size, tomographic coverage and spatial compounding parameters has achieved here an accurate hybrid imaging performance, which was experimentally showcased in tissuemimicking phantoms, post-mortem mice, and hand-held imaging of a healthy volunteer. The efficient combination of the two modalities in a single imaging device reveals the true power of functional and molecular imaging capacities of OAT in addition to the morphological and functional

  16. Progress report on the use of hybrid silicon pin diode arrays in high energy physics

    SciTech Connect

    Shapiro, S.L. ); Jernigan, J.G.; Arens, J.F. . Space Sciences Lab.)

    1990-05-01

    We report on the successful effort to develop hybrid PIN diode arrays and to demonstrate their potential as components of vertex detectors. Hybrid pixel arrays have been fabricated by the Hughes Aircraft Co. by bump-bonding readout chips developed by Hughes to an array of PIN diodes manufactured by Micron Semiconductor Inc. These hybrid pixel arrays were constructed in two configurations. One array format has 10 {times} 64 pixels, each 120 {mu}m square; and the other format has 256 {times} 156 pixels, each 30 {mu}m square. In both cases, the thickness of the PIN diode layer is 300 {mu}m. Measurements of detector performance show that excellent position resolution can be achieved by interpolation. By determining the centroid of the charge cloud which spreads charge into a number of neighboring pixels, a spatial resolution of a few microns has been attained. The noise has been measured to be about 300 electrons (rms) at room temperature, as expected from KTC and dark current considerations, yielding a signal-to-noise ratio of about 100 for minimum ionizing particles. 4 refs., 17 figs.

  17. Optimization of ultrasonic array inspections using an efficient hybrid model and real crack shapes

    SciTech Connect

    Felice, Maria V.; Velichko, Alexander Wilcox, Paul D.; Barden, Tim; Dunhill, Tony

    2015-03-31

    Models which simulate the interaction of ultrasound with cracks can be used to optimize ultrasonic array inspections, but this approach can be time-consuming. To overcome this issue an efficient hybrid model is implemented which includes a finite element method that requires only a single layer of elements around the crack shape. Scattering Matrices are used to capture the scattering behavior of the individual cracks and a discussion on the angular degrees of freedom of elastodynamic scatterers is included. Real crack shapes are obtained from X-ray Computed Tomography images of cracked parts and these shapes are inputted into the hybrid model. The effect of using real crack shapes instead of straight notch shapes is demonstrated. An array optimization methodology which incorporates the hybrid model, an approximate single-scattering relative noise model and the real crack shapes is then described.

  18. Optimization of ultrasonic array inspections using an efficient hybrid model and real crack shapes

    NASA Astrophysics Data System (ADS)

    Felice, Maria V.; Velichko, Alexander; Wilcox, Paul D.; Barden, Tim; Dunhill, Tony

    2015-03-01

    Models which simulate the interaction of ultrasound with cracks can be used to optimize ultrasonic array inspections, but this approach can be time-consuming. To overcome this issue an efficient hybrid model is implemented which includes a finite element method that requires only a single layer of elements around the crack shape. Scattering Matrices are used to capture the scattering behavior of the individual cracks and a discussion on the angular degrees of freedom of elastodynamic scatterers is included. Real crack shapes are obtained from X-ray Computed Tomography images of cracked parts and these shapes are inputted into the hybrid model. The effect of using real crack shapes instead of straight notch shapes is demonstrated. An array optimization methodology which incorporates the hybrid model, an approximate single-scattering relative noise model and the real crack shapes is then described.

  19. Energy spectrum of ultra-high energy cosmic rays observed with the Telescope Array using a hybrid technique

    NASA Astrophysics Data System (ADS)

    Abu-Zayyad, T.; Aida, R.; Allen, M.; Anderson, R.; Azuma, R.; Barcikowski, E.; Belz, J. W.; Bergman, D. R.; Blake, S. A.; Cady, R.; Cheon, B. G.; Chiba, J.; Chikawa, M.; Cho, E. J.; Cho, W. R.; Fujii, H.; Fujii, T.; Fukuda, T.; Fukushima, M.; Hanlon, W.; Hayashi, K.; Hayashi, Y.; Hayashida, N.; Hibino, K.; Hiyama, K.; Honda, K.; Iguchi, T.; Ikeda, D.; Ikuta, K.; Inoue, N.; Ishii, T.; Ishimori, R.; Ito, H.; Ivanov, D.; Iwamoto, S.; Jui, C. C. H.; Kadota, K.; Kakimoto, F.; Kalashev, O.; Kanbe, T.; Kasahara, K.; Kawai, H.; Kawakami, S.; Kawana, S.; Kido, E.; Kim, H. B.; Kim, H. K.; Kim, J. H.; Kim, J. H.; Kitamoto, K.; Kitamura, S.; Kitamura, Y.; Kobayashi, K.; Kobayashi, Y.; Kondo, Y.; Kuramoto, K.; Kuzmin, V.; Kwon, Y. J.; Lan, J.; Lim, S. I.; Lundquist, J. P.; Machida, S.; Martens, K.; Matsuda, T.; Matsuura, T.; Matsuyama, T.; Matthews, J. N.; Minamino, M.; Miyata, K.; Murano, Y.; Myers, I.; Nagasawa, K.; Nagataki, S.; Nakamura, T.; Nam, S. W.; Nonaka, T.; Ogio, S.; Ohnishi, M.; Ohoka, H.; Oki, K.; Oku, D.; Okuda, T.; Ono, M.; Oshima, A.; Ozawa, S.; Park, I. H.; Pshirkov, M. S.; Rodriguez, D. C.; Roh, S. Y.; Rubtsov, G.; Ryu, D.; Sagawa, H.; Sakurai, N.; Sampson, A. L.; Scott, L. M.; Shah, P. D.; Shibata, F.; Shibata, T.; Shimodaira, H.; Shin, B. K.; Shin, J. I.; Shirahama, T.; Smith, J. D.; Sokolsky, P.; Springer, R. W.; Stokes, B. T.; Stratton, S. R.; Stroman, T.; Suzuki, S.; Takahashi, Y.; Takeda, M.; Taketa, A.; Takita, M.; Tameda, Y.; Tanaka, H.; Tanaka, K.; Tanaka, M.; Thomas, S. B.; Thomson, G. B.; Tinyakov, P.; Tkachev, I.; Tokuno, H.; Tomida, T.; Troitsky, S.; Tsunesada, Y.; Tsutsumi, K.; Tsuyuguchi, Y.; Uchihori, Y.; Udo, S.; Ukai, H.; Urban, F.; Vasiloff, G.; Wada, Y.; Wong, T.; Yamakawa, Y.; Yamane, R.; Yamaoka, H.; Yamazaki, K.; Yang, J.; Yoneda, Y.; Yoshida, S.; Yoshii, H.; Zhou, X.; Zollinger, R.; Zundel, Z.

    2015-02-01

    We measure the spectrum of cosmic rays with energies greater than 1018.2 eV with the fluorescence detectors (FDs) and the surface detectors (SDs) of the Telescope Array Experiment using the data taken in our first 2.3-year observation from May 27, 2008 to September 7, 2010. A hybrid air shower reconstruction technique is employed to improve accuracies in determination of arrival directions and primary energies of cosmic rays using both FD and SD data. The energy spectrum presented here is in agreement with our previously published spectra and the HiRes results.

  20. Development of Hybrid Sensor Arrays for Sensor Arrays for Simultaneous Measurement of Pressure and Shear Stress Distribution

    NASA Technical Reports Server (NTRS)

    2000-01-01

    This document reports on the progress in developing hybrid sensors for the simultaneous measurement of pressure and shear stress. The key feature for the success of the proposed hybrid sensor array is the ability to deposit Cu-Ni alloy with proper composition (55 - 45) on a silicon wafer to form a strain gage. This alloy strain gage replaces the normally used Si strain gages in MEMS, which are highly nonlinear and temperature dependent. The copper nickel, with proper composition (55 - 45), was successfully deposited on a silicon wafer with a few trials during this period of the project. Pictures of the Cu-Ni alloy strain gage and the x-ray spectra indicating the composition are shown. The planned tests are also reviewed.

  1. Hybrid rocket engine, theoretical model and experiment

    NASA Astrophysics Data System (ADS)

    Chelaru, Teodor-Viorel; Mingireanu, Florin

    2011-06-01

    The purpose of this paper is to build a theoretical model for the hybrid rocket engine/motor and to validate it using experimental results. The work approaches the main problems of the hybrid motor: the scalability, the stability/controllability of the operating parameters and the increasing of the solid fuel regression rate. At first, we focus on theoretical models for hybrid rocket motor and compare the results with already available experimental data from various research groups. A primary computation model is presented together with results from a numerical algorithm based on a computational model. We present theoretical predictions for several commercial hybrid rocket motors, having different scales and compare them with experimental measurements of those hybrid rocket motors. Next the paper focuses on tribrid rocket motor concept, which by supplementary liquid fuel injection can improve the thrust controllability. A complementary computation model is also presented to estimate regression rate increase of solid fuel doped with oxidizer. Finally, the stability of the hybrid rocket motor is investigated using Liapunov theory. Stability coefficients obtained are dependent on burning parameters while the stability and command matrixes are identified. The paper presents thoroughly the input data of the model, which ensures the reproducibility of the numerical results by independent researchers.

  2. Small Arrays for Seismic Intruder Detections: A Simulation Based Experiment

    NASA Astrophysics Data System (ADS)

    Pitarka, A.

    2014-12-01

    Seismic sensors such as geophones and fiber optic have been increasingly recognized as promising technologies for intelligence surveillance, including intruder detection and perimeter defense systems. Geophone arrays have the capability to provide cost effective intruder detection in protecting assets with large perimeters. A seismic intruder detection system uses one or multiple arrays of geophones design to record seismic signals from footsteps and ground vehicles. Using a series of real-time signal processing algorithms the system detects, classify and monitors the intruder's movement. We have carried out numerical experiments to demonstrate the capability of a seismic array to detect moving targets that generate seismic signals. The seismic source is modeled as a vertical force acting on the ground that generates continuous impulsive seismic signals with different predominant frequencies. Frequency-wave number analysis of the synthetic array data was used to demonstrate the array's capability at accurately determining intruder's movement direction. The performance of the array was also analyzed in detecting two or more objects moving at the same time. One of the drawbacks of using a single array system is its inefficiency at detecting seismic signals deflected by large underground objects. We will show simulation results of the effect of an underground concrete block at shielding the seismic signal coming from an intruder. Based on simulations we found that multiple small arrays can greatly improve the system's detection capability in the presence of underground structures. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344

  3. Faculty Experiences in Higher Education Institutions Teaching Hybrid Courses

    ERIC Educational Resources Information Center

    Calderon, Blanca I. Rodriguez

    2013-01-01

    This qualitative phenomenological study investigated how professors perceive the effectiveness of hybrid courses at the university level. The study gathered data related to professor's experiences that could give insight about the factors encouraging the development of hybrid instruction in higher education. The targeted population consisted of…

  4. Adaptive multibeam phased array design for a Spacelab experiment

    NASA Technical Reports Server (NTRS)

    Noji, T. T.; Fass, S.; Fuoco, A. M.; Wang, C. D.

    1977-01-01

    The parametric tradeoff analyses and design for an Adaptive Multibeam Phased Array (AMPA) for a Spacelab experiment are described. This AMPA Experiment System was designed with particular emphasis to maximize channel capacity and minimize implementation and cost impacts for future austere maritime and aeronautical users, operating with a low gain hemispherical coverage antenna element, low effective radiated power, and low antenna gain-to-system noise temperature ratio.

  5. Biaxially stretchable supercapacitors based on the buckled hybrid fiber electrode array

    NASA Astrophysics Data System (ADS)

    Zhang, Nan; Zhou, Weiya; Zhang, Qiang; Luan, Pingshan; Cai, Le; Yang, Feng; Zhang, Xiao; Fan, Qingxia; Zhou, Wenbin; Xiao, Zhuojian; Gu, Xiaogang; Chen, Huiliang; Li, Kewei; Xiao, Shiqi; Wang, Yanchun; Liu, Huaping; Xie, Sishen

    2015-07-01

    In order to meet the growing need for smart bionic devices and epidermal electronic systems, biaxial stretchability is essential for energy storage units. Based on porous single-walled carbon nanotube/poly(3,4-ethylenedioxythiophene) (SWCNT/PEDOT) hybrid fiber, we designed and fabricated a biaxially stretchable supercapacitor, which possesses a unique configuration of the parallel buckled hybrid fiber array. Owing to the reticulate SWCNT film and the improved fabrication technique, the hybrid fiber retained its porous architecture both outwardly and inwardly, manifesting a superior capacity of 215 F g-1. H3PO4-polyvinyl alcohol gel with an optimized component ratio was introduced as both binder and stretchable electrolyte, which contributed to the regularity and stability of the buckled fiber array. The buckled structure and the quasi one-dimensional character of the fibers endow the supercapacitor with 100% stretchability along all directions. In addition, the supercapacitor exhibited good transparency, as well as excellent electrochemical properties and stability after being stretched 5000 times.In order to meet the growing need for smart bionic devices and epidermal electronic systems, biaxial stretchability is essential for energy storage units. Based on porous single-walled carbon nanotube/poly(3,4-ethylenedioxythiophene) (SWCNT/PEDOT) hybrid fiber, we designed and fabricated a biaxially stretchable supercapacitor, which possesses a unique configuration of the parallel buckled hybrid fiber array. Owing to the reticulate SWCNT film and the improved fabrication technique, the hybrid fiber retained its porous architecture both outwardly and inwardly, manifesting a superior capacity of 215 F g-1. H3PO4-polyvinyl alcohol gel with an optimized component ratio was introduced as both binder and stretchable electrolyte, which contributed to the regularity and stability of the buckled fiber array. The buckled structure and the quasi one-dimensional character of the

  6. Indium Hybridization of Large Format TES Bolometer Arrays to Readout Multiplexers for Far-Infrared Astronomy

    NASA Astrophysics Data System (ADS)

    Miller, Timothy M.; Costen, Nick; Allen, Christine

    2008-04-01

    In our effort to develop large format kilo-pixel arrays of transition edge sensors, we are working toward demonstrating electrical connectivity of a hybridized 32×40 element detector to a NIST multiplexer. The geometry of large-scale arrays that attempt to maintain a high filling factor does not allow for typical fan-out wiring, thus the detector array is hybridized directly to the readout multiplexer. The two parts are bonded together with 10 micron tall indium bumps, which complete the electrical path and also provide mechanical strength. The indium hybridization was developed and performed at the Goddard Space Flight Center and has been shown to withstand tensile loading up to 0.26 gram-force per indium bump. A cavity is deep etched behind each pixel prior to bonding, leaving only 30 micron support walls, which maintains a high filling fraction. Electrical continuity has been shown through the indium path in room temperature measurements. We report on the fabrication process used to hybridize the parts and the subsequent electrical performance.

  7. Vitis Phylogenomics: Hybridization Intensities from a SNP Array Outperform Genotype Calls

    PubMed Central

    Miller, Allison J.; Matasci, Naim; Schwaninger, Heidi; Aradhya, Mallikarjuna K.; Prins, Bernard; Zhong, Gan-Yuan; Simon, Charles; Buckler, Edward S.; Myles, Sean

    2013-01-01

    Understanding relationships among species is a fundamental goal of evolutionary biology. Single nucleotide polymorphisms (SNPs) identified through next generation sequencing and related technologies enable phylogeny reconstruction by providing unprecedented numbers of characters for analysis. One approach to SNP-based phylogeny reconstruction is to identify SNPs in a subset of individuals, and then to compile SNPs on an array that can be used to genotype additional samples at hundreds or thousands of sites simultaneously. Although powerful and efficient, this method is subject to ascertainment bias because applying variation discovered in a representative subset to a larger sample favors identification of SNPs with high minor allele frequencies and introduces bias against rare alleles. Here, we demonstrate that the use of hybridization intensity data, rather than genotype calls, reduces the effects of ascertainment bias. Whereas traditional SNP calls assess known variants based on diversity housed in the discovery panel, hybridization intensity data survey variation in the broader sample pool, regardless of whether those variants are present in the initial SNP discovery process. We apply SNP genotype and hybridization intensity data derived from the Vitis9kSNP array developed for grape to show the effects of ascertainment bias and to reconstruct evolutionary relationships among Vitis species. We demonstrate that phylogenies constructed using hybridization intensities suffer less from the distorting effects of ascertainment bias, and are thus more accurate than phylogenies based on genotype calls. Moreover, we reconstruct the phylogeny of the genus Vitis using hybridization data, show that North American subgenus Vitis species are monophyletic, and resolve several previously poorly known relationships among North American species. This study builds on earlier work that applied the Vitis9kSNP array to evolutionary questions within Vitis vinifera and has general

  8. Skylab experiment performance evaluation manual. Appendix S: Experiment T027 contamination measurement sample array (MSFC)

    NASA Technical Reports Server (NTRS)

    Tonetti, B. B.

    1973-01-01

    Analyses for Experiment T027, Contamination Measurement Sample Array (MSFC), to be used for evaluating the performance of the Skylab corrollary experiments under preflight, inflight, and post-flight conditions are presented. Experiment contingency plan workaround procedure and malfunction analyses are presented in order to assist in making the experiment operationally successful.

  9. Hybrid Rocket Experiment Station for Capstone Design

    NASA Technical Reports Server (NTRS)

    Conley, Edgar; Hull, Bethanne J.

    2012-01-01

    Portable hybrid rocket motors and test stands can be seen in many papers but none have been reported on the design or instrumentation at such a small magnitude. The design of this hybrid rocket and test stand is to be small and portable (suitcase size). This basic apparatus will be used for demonstrations in rocket propulsion. The design had to include all of the needed hardware to operate the hybrid rocket unit (with the exception of the external Oxygen tank). The design of this project includes making the correlation between the rocket's thrust and its size, the appropriate transducers (physical size, resolution, range, and cost), compatability with a laptop analog card, the ease of setup, and its portability.

  10. Muon Detector R&D in Telescope Array Experiment

    NASA Astrophysics Data System (ADS)

    Nonaka, T.; Takamura, M.; Honda, K.; Matthews, J. N.; Ogio, S.; Sakurai, N.; Sagawa, H.; Stokes, B. T.; Tsujimoto, M.; Yashiro, K.

    The Telescope Array (TA) experiment, located in the western desert of Utah, U.S.A., at 39.38° north and 112.9° west, is collecting data of ultra high energy cosmic rays in the energy range 1018-1020 eV. The experiment has a Surface Detector (SD) array surrounded by three Fluorescence Detector (FD) stations to enable simultaneous detection of shower particles and fluorescence photons generated by the extensive air shower. Measurement of shower particles at the ground level, with different absorber thickness, enables a more detailed studies of the experiment's energy scale and of hadron interaction models. In this report, we present a design and the first observation result of a surface muon detector using lead plates and concrete as absorbers.

  11. Active array design for FAME: Freeform Active Mirror Experiment

    NASA Astrophysics Data System (ADS)

    Jaskó, Attila; Aitink-Kroes, Gabby; Agócs, Tibor; Venema, Lars; Hugot, Emmanuel; Schnetler, Hermine; Bányai, Evelin

    2014-07-01

    In this paper a status report is given on the development of the FAME (Freeform Active Mirror Experiment) active array. Further information regarding this project can be found in the paper by Venema et al. (this conference). Freeform optics provide the opportunity to drastically reduce the complexity of the future optical instruments. In order to produce these non-axisymmetric freeform optics with up to 1 mm deviation from the best fit sphere, it is necessary to come up with new design and manufacturing methods. The way we would like to create novel freeform optics is by fine tuning a preformed high surface-quality thin mirror using an array which is actively controlled by actuators. In the following we introduce the tools deployed to create and assess the individual designs. The result is an active array having optimal number and lay-out of actuators.

  12. Neutron Capture Experiments Using the DANCE Array at Los Alamos

    SciTech Connect

    Dashdorj, D.; Mitchell, G. E.; Baramsai, B.; Chyzh, A.; Walker, C.; Agvaanluvsan, U.; Becker, J. A.; Parker, W.; Sleaford, B.; Wu, C. Y.; Bredeweg, T. A.; Couture, A.; Haight, R. C.; Jandel, M.; Rundberg, R. S.; Ullmann, J. L.; Vieira, D. J.; Wouters, J. M.; Krticka, M.; Becvar, F.

    2009-03-31

    The Detector for Advanced Neutron Capture Experiments (DANCE) is designed for neutron capture measurements on very small and/or radioactive targets. The DANCE array of 160 BaF{sub 2} scintillation detectors is located at the Lujan Center at the Los Alamos Neutron Science Center (LANSCE). Accurate measurements of neutron capture data are important for many current applications as well as for basic understanding of neutron capture. The gamma rays following neutron capture reactions have been studied by the time-of-flight technique using the DANCE array. The high granularity of the array allows measurements of the gamma-ray multiplicity. The gamma-ray multiplicities and energy spectra for different multiplicities can be measured and analyzed for spin and parity determination of the resolved resonances.

  13. Making hybrid [n]-rotaxanes as supramolecular arrays of molecular electron spin qubits

    NASA Astrophysics Data System (ADS)

    Fernandez, Antonio; Ferrando-Soria, Jesus; Pineda, Eufemio Moreno; Tuna, Floriana; Vitorica-Yrezabal, Iñigo J.; Knappke, Christiane; Ujma, Jakub; Muryn, Christopher A.; Timco, Grigore A.; Barran, Perdita E.; Ardavan, Arzhang; Winpenny, Richard E. P.

    2016-01-01

    Quantum information processing (QIP) would require that the individual units involved--qubits--communicate to other qubits while retaining their identity. In many ways this resembles the way supramolecular chemistry brings together individual molecules into interlocked structures, where the assembly has one identity but where the individual components are still recognizable. Here a fully modular supramolecular strategy has been to link hybrid organic-inorganic [2]- and [3]-rotaxanes into still larger [4]-, [5]- and [7]-rotaxanes. The ring components are heterometallic octanuclear [Cr7NiF8(O2CtBu)16]- coordination cages and the thread components template the formation of the ring about the organic axle, and are further functionalized to act as a ligand, which leads to large supramolecular arrays of these heterometallic rings. As the rings have been proposed as qubits for QIP, the strategy provides a possible route towards scalable molecular electron spin devices for QIP. Double electron-electron resonance experiments demonstrate inter-qubit interactions suitable for mediating two-qubit quantum logic gates.

  14. Making hybrid [n]-rotaxanes as supramolecular arrays of molecular electron spin qubits.

    PubMed

    Fernandez, Antonio; Ferrando-Soria, Jesus; Pineda, Eufemio Moreno; Tuna, Floriana; Vitorica-Yrezabal, Iñigo J; Knappke, Christiane; Ujma, Jakub; Muryn, Christopher A; Timco, Grigore A; Barran, Perdita E; Ardavan, Arzhang; Winpenny, Richard E P

    2016-01-01

    Quantum information processing (QIP) would require that the individual units involved--qubits--communicate to other qubits while retaining their identity. In many ways this resembles the way supramolecular chemistry brings together individual molecules into interlocked structures, where the assembly has one identity but where the individual components are still recognizable. Here a fully modular supramolecular strategy has been to link hybrid organic-inorganic [2]- and [3]-rotaxanes into still larger [4]-, [5]- and [7]-rotaxanes. The ring components are heterometallic octanuclear [Cr7NiF8(O2C(t)Bu)16](-) coordination cages and the thread components template the formation of the ring about the organic axle, and are further functionalized to act as a ligand, which leads to large supramolecular arrays of these heterometallic rings. As the rings have been proposed as qubits for QIP, the strategy provides a possible route towards scalable molecular electron spin devices for QIP. Double electron-electron resonance experiments demonstrate inter-qubit interactions suitable for mediating two-qubit quantum logic gates. PMID:26742716

  15. Making hybrid [n]-rotaxanes as supramolecular arrays of molecular electron spin qubits

    PubMed Central

    Fernandez, Antonio; Ferrando-Soria, Jesus; Pineda, Eufemio Moreno; Tuna, Floriana; Vitorica-Yrezabal, Iñigo J.; Knappke, Christiane; Ujma, Jakub; Muryn, Christopher A.; Timco, Grigore A.; Barran, Perdita E.; Ardavan, Arzhang; Winpenny, Richard E.P.

    2016-01-01

    Quantum information processing (QIP) would require that the individual units involved—qubits—communicate to other qubits while retaining their identity. In many ways this resembles the way supramolecular chemistry brings together individual molecules into interlocked structures, where the assembly has one identity but where the individual components are still recognizable. Here a fully modular supramolecular strategy has been to link hybrid organic–inorganic [2]- and [3]-rotaxanes into still larger [4]-, [5]- and [7]-rotaxanes. The ring components are heterometallic octanuclear [Cr7NiF8(O2CtBu)16]– coordination cages and the thread components template the formation of the ring about the organic axle, and are further functionalized to act as a ligand, which leads to large supramolecular arrays of these heterometallic rings. As the rings have been proposed as qubits for QIP, the strategy provides a possible route towards scalable molecular electron spin devices for QIP. Double electron–electron resonance experiments demonstrate inter-qubit interactions suitable for mediating two-qubit quantum logic gates. PMID:26742716

  16. Fully integrated hybrid silicon free-space beam steering source with 32-channel phased array

    NASA Astrophysics Data System (ADS)

    Hulme, J. C.; Doylend, J. K.; Heck, M. J. R.; Peters, J. D.; Davenport, M. L.; Bovington, J. T.; Coldren, L. A.; Bowers, J. E.

    2014-03-01

    Free-space beam steering using optical phased arrays is a promising method for implementing free-space communication links and Light Detection and Ranging (LIDAR) without the sensitivity to inertial forces and long latencies which characterize moving parts. Implementing this approach on a silicon-based photonic integrated circuit adds the additional advantage of working with highly developed CMOS processing techniques. In this work we discuss our progress in the development of a fully integrated 32 channel PIC with a widely tunable diode laser, a waveguide phased array, an array of fast phase modulators, an array of hybrid III-V/silicon amplifiers, surface gratings, and a graded index lens (GRIN) feeding an array of photodiodes for feedback control. The PIC has been designed to provide beam steering across a 15°x5° field of view with 0.6°x0.6° beam width and background peaks suppressed 15 dB relative to the main lobe within the field of view for arbitrarily chosen beam directions. Fabrication follows the hybrid silicon process developed at UCSB with modifications to incorporate silicon diodes and a GRIN lens.

  17. A Hybrid Particle Swarm with Differential Evolution Operator Approach (DEPSO) for Linear Array Synthesis

    NASA Astrophysics Data System (ADS)

    Sarkar, Soham; Das, Swagatam

    In recent years particle swarm optimization emerges as one of the most efficient global optimization tools. In this paper, a hybrid particle swarm with differential evolution operator, termed DEPSO, is applied for the synthesis of linear array geometry. Here, the minimum side lobe level and null control, both are obtained by optimizing the spacing between the array elements by this technique. Moreover, a statistical comparison is also provided to establish its performance against the results obtained by Genetic Algorithm (GA), classical Particle Swarm Optimization (PSO), Tabu Search Algorithm (TSA), Differential Evolution (DE) and Memetic Algorithm (MA).

  18. Maize and tripsacum: experiments in intergeneric hybridization

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Research in maize-Tripsacum hybridization is extensive and encompasses a period of more than 60 years of collective research. The publication “The origin of Indian corn and its relatives” describes some of the initial research in this area (Mangelsdorf and Reeves, 1939) and is recommended reading f...

  19. Measurement of the proton-air cross section with Telescope Array's Middle Drum detector and surface array in hybrid mode

    NASA Astrophysics Data System (ADS)

    Abbasi, R. U.; Abe, M.; Abu-Zayyad, T.; Allen, M.; Azuma, R.; Barcikowski, E.; Belz, J. W.; Bergman, D. R.; Blake, S. A.; Cady, R.; Chae, M. J.; Cheon, B. G.; Chiba, J.; Chikawa, M.; Cho, W. R.; Fujii, T.; Fukushima, M.; Goto, T.; Hanlon, W.; Hayashi, Y.; Hayashida, N.; Hibino, K.; Honda, K.; Ikeda, D.; Inoue, N.; Ishii, T.; Ishimori, R.; Ito, H.; Ivanov, D.; Jui, C. C. H.; Kadota, K.; Kakimoto, F.; Kalashev, O.; Kasahara, K.; Kawai, H.; Kawakami, S.; Kawana, S.; Kawata, K.; Kido, E.; Kim, H. B.; Kim, J. H.; Kim, J. H.; Kitamura, S.; Kitamura, Y.; Kuzmin, V.; Kwon, Y. J.; Lan, J.; Lim, S. I.; Lundquist, J. P.; Machida, K.; Martens, K.; Matsuda, T.; Matsuyama, T.; Matthews, J. N.; Minamino, M.; Mukai, Y.; Myers, I.; Nagasawa, K.; Nagataki, S.; Nakamura, T.; Nonaka, T.; Nozato, A.; Ogio, S.; Ogura, J.; Ohnishi, M.; Ohoka, H.; Oki, K.; Okuda, T.; Ono, M.; Oshima, A.; Ozawa, S.; Park, I. H.; Pshirkov, M. S.; Rodriguez, D. C.; Rubtsov, G.; Ryu, D.; Sagawa, H.; Sakurai, N.; Scott, L. M.; Shah, P. D.; Shibata, F.; Shibata, T.; Shimodaira, H.; Shin, B. K.; Shin, H. S.; Smith, J. D.; Sokolsky, P.; Springer, R. W.; Stokes, B. T.; Stratton, S. R.; Stroman, T. A.; Suzawa, T.; Takamura, M.; Takeda, M.; Takeishi, R.; Taketa, A.; Takita, M.; Tameda, Y.; Tanaka, H.; Tanaka, K.; Tanaka, M.; Thomas, S. B.; Thomson, G. B.; Tinyakov, P.; Tkachev, I.; Tokuno, H.; Tomida, T.; Troitsky, S.; Tsunesada, Y.; Tsutsumi, K.; Uchihori, Y.; Udo, S.; Urban, F.; Vasiloff, G.; Wong, T.; Yamane, R.; Yamaoka, H.; Yamazaki, K.; Yang, J.; Yashiro, K.; Yoneda, Y.; Yoshida, S.; Yoshii, H.; Zollinger, R.; Zundel, Z.; Telescope Array Collaboration

    2015-08-01

    In this work we are reporting on the measurement of the proton-air inelastic cross section σp-air inel using the Telescope Array detector. Based on the measurement of the σp-air inel, the proton-proton cross section σp -p value is also determined at √{s }=9 5-8+5 TeV . Detecting cosmic ray events at ultrahigh energies with the Telescope Array enables us to study this fundamental parameter that we are otherwise unable to access with particle accelerators. The data used in this report are the hybrid events observed by the Middle Drum fluorescence detector together with the surface array detector collected over five years. The value of the σp-air inel is found to be equal to 567.0 ±70.5 [Stat]-25+29[Sys] mb . The total proton-proton cross section is subsequently inferred from Glauber formalism and the Block, Halzen and Stanev QCD inspired fit and is found to be equal to 17 0-44+48[Stat]-17+19[Sys] mb .

  20. The Polarbear-2 and the Simons Array Experiments

    NASA Astrophysics Data System (ADS)

    Suzuki, A.; Ade, P.; Akiba, Y.; Aleman, C.; Arnold, K.; Baccigalupi, C.; Barch, B.; Barron, D.; Bender, A.; Boettger, D.; Borrill, J.; Chapman, S.; Chinone, Y.; Cukierman, A.; Dobbs, M.; Ducout, A.; Dunner, R.; Elleflot, T.; Errard, J.; Fabbian, G.; Feeney, S.; Feng, C.; Fujino, T.; Fuller, G.; Gilbert, A.; Goeckner-Wald, N.; Groh, J.; Haan, T. De; Hall, G.; Halverson, N.; Hamada, T.; Hasegawa, M.; Hattori, K.; Hazumi, M.; Hill, C.; Holzapfel, W.; Hori, Y.; Howe, L.; Inoue, Y.; Irie, F.; Jaehnig, G.; Jaffe, A.; Jeong, O.; Katayama, N.; Kaufman, J.; Kazemzadeh, K.; Keating, B.; Kermish, Z.; Keskitalo, R.; Kisner, T.; Kusaka, A.; Jeune, M. Le; Lee, A.; Leon, D.; Linder, E.; Lowry, L.; Matsuda, F.; Matsumura, T.; Miller, N.; Mizukami, K.; Montgomery, J.; Navaroli, M.; Nishino, H.; Peloton, J.; Poletti, D.; Puglisi, G.; Rebeiz, G.; Raum, C.; Reichardt, C.; Richards, P.; Ross, C.; Rotermund, K.; Segawa, Y.; Sherwin, B.; Shirley, I.; Siritanasak, P.; Stebor, N.; Stompor, R.; Suzuki, J.; Tajima, O.; Takada, S.; Takakura, S.; Takatori, S.; Tikhomirov, A.; Tomaru, T.; Westbrook, B.; Whitehorn, N.; Yamashita, T.; Zahn, A.; Zahn, O.

    2016-08-01

    We present an overview of the design and status of the Polarbear-2 and the Simons Array experiments. Polarbear-2 is a cosmic microwave background polarimetry experiment which aims to characterize the arc-minute angular scale B-mode signal from weak gravitational lensing and search for the degree angular scale B-mode signal from inflationary gravitational waves. The receiver has a 365 mm diameter focal plane cooled to 270 mK. The focal plane is filled with 7588 dichroic lenslet-antenna-coupled polarization sensitive transition edge sensor (TES) bolometric pixels that are sensitive to 95 and 150 GHz bands simultaneously. The TES bolometers are read-out by SQUIDs with 40 channel frequency domain multiplexing. Refractive optical elements are made with high-purity alumina to achieve high optical throughput. The receiver is designed to achieve noise equivalent temperature of 5.8 \\upmu K_CMB√{s} in each frequency band. Polarbear-2 will deploy in 2016 in the Atacama desert in Chile. The Simons Array is a project to further increase sensitivity by deploying three Polarbear-2 type receivers. The Simons Array will cover 95, 150, and 220 GHz frequency bands for foreground control. The Simons Array will be able to constrain tensor-to-scalar ratio and sum of neutrino masses to σ (r) = 6× 10^{-3} at r = 0.1 and sum m_{\\upnu } (σ =1) to 40 meV.

  1. The uc(Polarbear)-2 and the Simons Array Experiments

    NASA Astrophysics Data System (ADS)

    Suzuki, A.; Ade, P.; Akiba, Y.; Aleman, C.; Arnold, K.; Baccigalupi, C.; Barch, B.; Barron, D.; Bender, A.; Boettger, D.; Borrill, J.; Chapman, S.; Chinone, Y.; Cukierman, A.; Dobbs, M.; Ducout, A.; Dunner, R.; Elleflot, T.; Errard, J.; Fabbian, G.; Feeney, S.; Feng, C.; Fujino, T.; Fuller, G.; Gilbert, A.; Goeckner-Wald, N.; Groh, J.; Haan, T. De; Hall, G.; Halverson, N.; Hamada, T.; Hasegawa, M.; Hattori, K.; Hazumi, M.; Hill, C.; Holzapfel, W.; Hori, Y.; Howe, L.; Inoue, Y.; Irie, F.; Jaehnig, G.; Jaffe, A.; Jeong, O.; Katayama, N.; Kaufman, J.; Kazemzadeh, K.; Keating, B.; Kermish, Z.; Keskitalo, R.; Kisner, T.; Kusaka, A.; Jeune, M. Le; Lee, A.; Leon, D.; Linder, E.; Lowry, L.; Matsuda, F.; Matsumura, T.; Miller, N.; Mizukami, K.; Montgomery, J.; Navaroli, M.; Nishino, H.; Peloton, J.; Poletti, D.; Puglisi, G.; Rebeiz, G.; Raum, C.; Reichardt, C.; Richards, P.; Ross, C.; Rotermund, K.; Segawa, Y.; Sherwin, B.; Shirley, I.; Siritanasak, P.; Stebor, N.; Stompor, R.; Suzuki, J.; Tajima, O.; Takada, S.; Takakura, S.; Takatori, S.; Tikhomirov, A.; Tomaru, T.; Westbrook, B.; Whitehorn, N.; Yamashita, T.; Zahn, A.; Zahn, O.

    2016-01-01

    We present an overview of the design and status of the uc(Polarbear)-2 and the Simons Array experiments. uc(Polarbear)-2 is a cosmic microwave background polarimetry experiment which aims to characterize the arc-minute angular scale B-mode signal from weak gravitational lensing and search for the degree angular scale B-mode signal from inflationary gravitational waves. The receiver has a 365 mm diameter focal plane cooled to 270 mK. The focal plane is filled with 7588 dichroic lenslet-antenna-coupled polarization sensitive transition edge sensor (TES) bolometric pixels that are sensitive to 95 and 150 GHz bands simultaneously. The TES bolometers are read-out by SQUIDs with 40 channel frequency domain multiplexing. Refractive optical elements are made with high-purity alumina to achieve high optical throughput. The receiver is designed to achieve noise equivalent temperature of 5.8 \\upmu K_CMB√{s} in each frequency band. uc(Polarbear)-2 will deploy in 2016 in the Atacama desert in Chile. The Simons Array is a project to further increase sensitivity by deploying three uc(Polarbear)-2 type receivers. The Simons Array will cover 95, 150, and 220 GHz frequency bands for foreground control. The Simons Array will be able to constrain tensor-to-scalar ratio and sum of neutrino masses to σ (r) = 6× 10^{-3} at r = 0.1 and sum m_{\\upnu } (σ =1) to 40 meV.

  2. Discrete mechanism damping effects in the solar array flight experiment

    NASA Technical Reports Server (NTRS)

    Pinson, E. D.

    1986-01-01

    Accelerometer data were collected during on-orbit structural dynamic testing of the Solar Array Flight Experiment aboard the Space Shuttle, and were analyzed at Lockheed Missile and Space Co. to determine the amount of damping present in the structure. The results of this analysis indicated that the damping present in the fundamental in-plane mode of the structure substantially exceeded that of the fundamental out-of-plane mode. In an effort to determine the source of the higher in-plane damping, a test was performed involving a small device known as a constant-force spring motor or constant-torque mechanism. Results from this test indicate that this discrete device is at least partially responsible for the increased in-plane modal damping of the Solar Array Flight Experiment structure.

  3. Application of Array Comparative Genomic Hybridization in Newborns with Multiple Congenital Anomalies.

    PubMed

    Szczałuba, Krzysztof; Nowakowska, Beata; Sobecka, Katarzyna; Smyk, Marta; Castaneda, Jennifer; Klapecki, Jakub; Kutkowska-Kaźmierczak, Anna; Śmigiel, Robert; Bocian, Ewa; Radkowski, Marek; Demkow, Urszula

    2016-01-01

    Major congenital anomalies are detectable in 2-3 % of the newborn population. Some of their genetic causes are attributable to copy number variations identified by array comparative genomic hybridization (aCGH). The value of aCGH screening as a first-tier test in children with multiple congenital anomalies has been studied and consensus adopted. However, array resolution has not been agreed upon, specifically in the newborn or infant population. Moreover, most array studies have been focused on mixed populations of intellectual disability/developmental delay with or without multiple congenital anomalies, making it difficult to assess the value of microarrays in newborns. The aim of the study was to determine the optimal quality and clinical sensitivity of high-resolution array comparative genomic hybridization in neonates with multiple congenital anomalies. We investigated a group of 54 newborns with multiple congenital anomalies defined as two or more birth defects from more than one organ system. Cytogenetic studies were performed using OGT CytoSure 8 × 60 K microarray. We found ten rearrangements in ten newborns. Of these, one recurrent syndromic microduplication was observed, whereas all other changes were unique. Six rearrangements were definitely pathogenic, including one submicroscopic and five that could be seen on routine karyotype analysis. Four other copy number variants were likely pathogenic. The candidate genes that may explain the phenotype were discussed. In conclusion, high-resolution array comparative hybridization can be applied successfully in newborns with multiple congenital anomalies as the method detects a significant number of pathogenic changes, resulting in early diagnoses. We hypothesize that small changes previously considered benign or even inherited rearrangements should be classified as potentially pathogenic at least until a subsequent clinical assessment would exclude a developmental delay or dysmorphism. PMID:26987320

  4. Synthesis of porous NiO/CeO2 hybrid nanoflake arrays as a platform for electrochemical biosensing

    NASA Astrophysics Data System (ADS)

    Cui, Jiewu; Luo, Jinbao; Peng, Bangguo; Zhang, Xinyi; Zhang, Yong; Wang, Yan; Qin, Yongqiang; Zheng, Hongmei; Shu, Xia; Wu, Yucheng

    2015-12-01

    Porous NiO/CeO2 hybrid nanoflake arrays fabricated by a facile hydrothermal method were employed as substrates for electrochemical biosensors. The resulting NiO/CeO2 hybrid nanoflake arrays with a large specific surface area and good biocompatibility presented an excellent platform for electrochemical biosensing.Porous NiO/CeO2 hybrid nanoflake arrays fabricated by a facile hydrothermal method were employed as substrates for electrochemical biosensors. The resulting NiO/CeO2 hybrid nanoflake arrays with a large specific surface area and good biocompatibility presented an excellent platform for electrochemical biosensing. Electronic supplementary information (ESI) available: Optical photographs of the as-prepared samples, SEM, TEM, EDS, XRD and BET data of the samples are presented, I-t curves of glucose biosensors based on NiO and NiO/CeO2 NFAs, EIS results of different electrodes. See DOI: 10.1039/c5nr05924k

  5. Fabrication of large-area arrays of hybrid nanostructures on polymer-derived chemically patterned surfaces

    NASA Astrophysics Data System (ADS)

    Liu, Xiaoying; Nepal, Dhriti; Biswas, Sushmita; Park, Kyoungweon; Vaia, Richard; Nealey, Paul; Air Force Research Laboratories Collaboration; University of Chicago Team

    2014-03-01

    The precise placement and assembly of nanoparticles (NPs) into large-area nanostructure arrays will allow for the design and implementation of advanced nanoscale devices for applications in fields such as quantum computing, optical sensing, superlenses, photocatalysis, photovoltaics, and non-linear optics. Our work is focused on using chemically nanopatterned surfaces to fabricate arrays of hybrid nanostructures with each component of the building block at well-defined positions. The precise chemical contrast patterns with densities and resolution of features created using standard tools of lithography, polymer self-assembly, and surface functionalization allow for control of position and interparticle spacing through selective surface-particle and particle-particle interactions. We have demonstrated the assembly of NPs, including metallic NPs and semiconductor quantum dots, into arrays of hybrid structures with various geometries, such as monomers, dimers, quatrefoils, stripes, and chains. We have developed protocols to fabricate NP arrays over a variety of substrates, which allows for the design and characterization of optical and electronic nanostructures and devices to meet the requirements of various technological applications.

  6. Synchronization for an array of neural networks with hybrid coupling by a novel pinning control strategy.

    PubMed

    Gong, Dawei; Lewis, Frank L; Wang, Liping; Xu, Ke

    2016-05-01

    In this paper, a novel pinning synchronization (synchronization with pinning control) scheme for an array of neural networks with hybrid coupling is investigated. The main contributions are as follows: (1) A novel pinning control strategy is proposed for the first time. Pinning control schemes are introduced as an array of column vector. The controllers are designed as simple linear systems, which are easy to be analyzed or tested. (2) Augmented Lyapunov-Krasovskii functional (LKF) is applied to introduce more relax variables, which can alleviate the requirements of the positive definiteness of the matrix. (3) Based on the appropriate LKF, by introducing some free weighting matrices, some novel synchronization criteria are derived. Furthermore, the proposed pinning control scheme described by column vector can also be expanded to almost all the other array of neural networks. Finally, numerical examples are provided to show the effectiveness of the proposed results. PMID:26922719

  7. Ion cyclotron and lower hybrid arrays applicable to current drive in fusion reactors

    NASA Astrophysics Data System (ADS)

    Bosia, G.; Helou, W.; Goniche, M.; Hillaret, J.; Ragona, R.

    2014-02-01

    This paper presents concepts for Ion Cyclotron and Lower Hybrid Current Drive arrays applicable to fusion reactors and based on periodically loaded line power division. It is shown that, in large arrays, such as the ones proposed for fusion reactor applications, these schemes can offer, in principle, a number of practical advantages, compared with currently adopted ones, such as in-blanket operation at significantly reduced power density, lay out suitable for water cooling, single ended or balanced power feed, simple and load independent impedance matching In addition, a remote and accurate real time measurement of the complex impedance of all array elements as well as detection, location, and measurement of the complex admittance of a single arc occurring anywhere in the structure is possible.

  8. Solar array experiments on the SPHINX satellite. [Space Plasma High voltage INteraction eXperiment satellite

    NASA Technical Reports Server (NTRS)

    Stevens, N. J.

    1974-01-01

    The Space Plasma, High Voltage Interaction Experiment (SPHINX) is the name given to an auxiliary payload satellite scheduled to be launched in January 1974. The principal experiments carried on this satellite are specifically designed to obtain the engineering data on the interaction of high voltage systems with the space plasma. The classes of experiments are solar array segments, insulators, insulators with pin holes and conductors. The satellite is also carrying experiments to obtain flight data on three new solar array configurations: the edge illuminated-multijunction cells, the teflon encased cells, and the violet cells.

  9. Data Analysis for Sequencing by Hybridization (SBH) Experiments

    SciTech Connect

    Salbego, David

    1995-11-28

    SCORES is user friendly software designed to analyze data from SBH (Sequencing By Hybridization) experiments. In these ANL experiments DNA samples are spotted on a nylon membrane and hybridized with radioactivity labeled oligonucleotide probes. An image analysis program (DOTS) calculates a raw value for each DNA dot from images generated by the Molecular Dynamics Phosphorimager. SCORES reads in the DOTS output for each hybridization done for a particular filter. The data for each probe is normalized against a mass probe and scaled properly. These values from 100 or more probes are then used to compute the distance (i.e., degree of similarity) between any two clones on the filter. These calculated distances define clusters of similar clones (cDNA)or contigs (genomic DNA). Histograms of the data at each stage of analysis to establish thresholds for further steps. SCORES generates various statistical tables to evaluate the quality of spotting, hybridization of filters, and of individual dots.

  10. Advanced numerical modeling and hybridization techniques for third-generation infrared detector pixel arrays

    NASA Astrophysics Data System (ADS)

    Schuster, Jonathan

    to their final hybridization onto expensive silicon read-out integrated circuit (ROIC) chips. The approach is to temporarily hybridize each candidate HgCdTe detector array to a standard reusable ROIC for complete screen testing. We tested the technique by temporarily hybridizing LPE grown HgCdTe test chips to fan-out boards and characterizing their performance.

  11. Nanoparticle-nanocup hybrid array structure with a tunable sensitivity for colorimetric biosensing

    NASA Astrophysics Data System (ADS)

    Seo, Sujin; Liu, Gang L.

    2016-03-01

    Colorimetric detection is cost-effective and user-friendly when used for sensing target analytes without a need of bulky and expensive equipment. The extraordinary transmission phenomena through plasmonic periodic nanocup arrays achieve colorimetric sensing by detecting color changes of transmitted light associated with the refractive index variation. The application of the nanocup arrays, however, is relatively restricted due to a limited sensitivity for monolayered target analyte detections on the surface. In order to improve the sensitivity bounded by the underlying nanostructures, hybrid nanoparticle (NP) - nanocup array substrates are developed for enhancing the sensitivity to the refractive index change. The three dimensionally assembled Au NPs in circle along the sidewall of each nanocup increases the density of hot spots by the heterogeneous plasmonic coupling between the NP and the edge of the nanocup; thus a small refractive index change at the hot spot becomes easily detected than bare nanocup arrays. In addition to the bulk refractive index sensing, an ultrasensitive spectroscopic detection of the antigen-antibody binding is achieved by this three-dimensional self-assembly of Au NPs on the Au nanocup arrays.

  12. Fabrication and characterization of a hybrid SOI 1×4 silicon-slot optical modulator array incorporating EO polymers for optical phased-array antenna applications

    NASA Astrophysics Data System (ADS)

    Kim, Richard S.; Szep, Attila; Usechak, Nicholas G.; Chen, Antao; Sun, Haishan; Shi, Shouyuan; Abeysinghe, Don; You, Young-Hwan; Dalton, Larry R.

    2012-03-01

    Optical phased arrays are promising candidates for both RF signal processing and optical beam forming and steering. These platforms not only enable accurate electrically controlled beam steering at high frequencies but also have the potential to significantly improve the performance of future free-space optical communications systems. In this work we exploit recent advancements in both nano-scale hybrid silicon-slot waveguides and electro-optic (EO) polymers to demonstrate an integrated optical phased-array antenna. Specifically, we create a hybrid integrated "photonic circuit" that connects an array of optical phase modulators, fed by a common optical signal and a 1x4 splitter, to a compact optical waveguide diffraction array for optical beam steering applications. The fundamental characteristics of the resulting integrated optical beam former, including the optical insertion loss, driving voltage, and phase control from the waveguide aperture are summarized in this letter.

  13. Biaxially stretchable supercapacitors based on the buckled hybrid fiber electrode array.

    PubMed

    Zhang, Nan; Zhou, Weiya; Zhang, Qiang; Luan, Pingshan; Cai, Le; Yang, Feng; Zhang, Xiao; Fan, Qingxia; Zhou, Wenbin; Xiao, Zhuojian; Gu, Xiaogang; Chen, Huiliang; Li, Kewei; Xiao, Shiqi; Wang, Yanchun; Liu, Huaping; Xie, Sishen

    2015-08-01

    In order to meet the growing need for smart bionic devices and epidermal electronic systems, biaxial stretchability is essential for energy storage units. Based on porous single-walled carbon nanotube/poly(3,4-ethylenedioxythiophene) (SWCNT/PEDOT) hybrid fiber, we designed and fabricated a biaxially stretchable supercapacitor, which possesses a unique configuration of the parallel buckled hybrid fiber array. Owing to the reticulate SWCNT film and the improved fabrication technique, the hybrid fiber retained its porous architecture both outwardly and inwardly, manifesting a superior capacity of 215 F g(-1). H3PO4-polyvinyl alcohol gel with an optimized component ratio was introduced as both binder and stretchable electrolyte, which contributed to the regularity and stability of the buckled fiber array. The buckled structure and the quasi one-dimensional character of the fibers endow the supercapacitor with 100% stretchability along all directions. In addition, the supercapacitor exhibited good transparency, as well as excellent electrochemical properties and stability after being stretched 5000 times. PMID:26136109

  14. Solar Array Module Plasma Interaction Experiment (SAMPIE): Technical requirements document

    NASA Technical Reports Server (NTRS)

    Hillard, G. Barry; Ferguson, Dale C.

    1992-01-01

    The Solar Array Module Plasma Interactions Experiment (SAMPIE) is a NASA shuttle space flight experiment scheduled for launch in early 1994. The SAMPIE experiment will investigate plasma interactions of high voltage space power systems in low earth orbit. Solar cell modules, representing several technologies, will be biased to high voltages to characterize both arcing and plasma current collection. Other solar modules, specially modified in accordance with current theories of arcing and breakdown, will demonstrate the possibility of arc suppression. Finally, several test modules will be included to study the basic nature of these interactions. The science and technology goals for the project are defined in the Technical Requirements Document (TRD) which is presented here.

  15. Toward Evolvable Hardware Chips: Experiments with a Programmable Transistor Array

    NASA Technical Reports Server (NTRS)

    Stoica, Adrian

    1998-01-01

    Evolvable Hardware is reconfigurable hardware that self-configures under the control of an evolutionary algorithm. We search for a hardware configuration can be performed using software models or, faster and more accurate, directly in reconfigurable hardware. Several experiments have demonstrated the possibility to automatically synthesize both digital and analog circuits. The paper introduces an approach to automated synthesis of CMOS circuits, based on evolution on a Programmable Transistor Array (PTA). The approach is illustrated with a software experiment showing evolutionary synthesis of a circuit with a desired DC characteristic. A hardware implementation of a test PTA chip is then described, and the same evolutionary experiment is performed on the chip demonstrating circuit synthesis/self-configuration directly in hardware.

  16. Construction of a radiation hybrid panel and the first yellowtail (Seriola quinqueradiata) radiation hybrid map using a nanofluidic dynamic array

    PubMed Central

    2014-01-01

    Background Yellowtail (Seriola quinqueradiata) are an economically important species in Japan. However, there are currently no methods for captive breeding and early rearing for yellowtail. Thus, the commercial cultivation of this species is reliant upon the capture of wild immature fish. Given this, there is a need to develop captive breeding techniques to reduce pressure on wild stocks and facilitate the sustainable development of yellowtail aquaculture. We constructed a whole genome radiation hybrid (RH) panel for yellowtail gene mapping and developed a framework physical map using a nanofluidic dynamic array to use SNPs (single nucleotide polymorphisms) in ESTs (expressed sequence tags) for the DNA-assisted breeding of yellowtail. Results Clonal RH cell lines were obtained after ionizing radiation; specifically, 78, 64, 129, 55, 42, and 53 clones were isolated after treatment with 3,000, 4,000, 5,000, 6,000, 8,000, or 10,000 rads, respectively. A total of 421 hybrid cell lines were obtained by fusion with mouse B78 cells. Ninety-four microsatellite markers used in the genetic linkage map were genotyped using the 421 hybrid cell lines. Based upon marker retention and genome coverage, we selected 93 hybrid cell lines to form an RH panel. Importantly, we performed the first genotyping of yellowtail markers in an RH panel using a nanofluidic dynamic array (Fluidigm, CA, USA). Then, 580 markers containing ESTs and SNPs were mapped in the first yellowtail RH map. Conclusions We successfully developed a yellowtail RH panel to facilitate the localization of markers. Using this, a framework RH map was constructed with 580 markers. This high-density physical map will serve as a useful tool for the identification of genes related to important breeding traits using genetic structural information, such as conserved synteny. Moreover, in a comparison of 30 sequences in the RH group 1 (SQ1), yellowtail appeared to be evolutionarily closer to medaka and the green

  17. A torquing shearing interferometer for cylindrical wire array experiments

    SciTech Connect

    Pikuz, S. A.; Schrafel, P. C.; Shelkovenko, T. A.; Kusse, B. R.

    2008-10-15

    In standard shearing interferometry, a single probing beam passes through a perturbing medium and is then split into two beams. A linear shift results in an overlap, an interference, and a fringe pattern yielding the perturbing medium density profile. The probing beam usually needs to be larger than the perturbing medium so that part of it passes through a well separated low density region. During early time axial (end-on) views of imploding cylindrical wire arrays low density regions lie in between the high density regions that are near the initial wire positions. In addition, for end-on viewing, the probing beam diameter is limited by electrodes and is comparable to the array diameter. In this case a linear translation will not work but the overlap can be accomplished by an azimuthal rotation of one beam with respect to the other. Such a torquing shearing interferometer has been set up on the COBRA experiment to give time resolved, radial, and azimuthal electron density profiles during early time cylindrical wire array implosions.

  18. Orthogonal arrays for computer experiments to assess important inputs

    SciTech Connect

    Moore, L. M.; McKay, Michael D.

    2002-01-01

    The topic of this paper is experiment planning, particularly fractional factorial designs or orthogonal arrays, for computer experiments to assess important inputs. The work presented in the paper is motivated by considering a non-stochastic computer simulation which has many inputs and which can, in a reasonable period of time, be run thousands of times. With many inputs, information that allows focus on a subset of important inputs is valuable. The characterization of 'importance' is expected to follow suggestions in McKay (1995) or McKay, et al. (1992). This analysis approach leads to considering factorial experiment designs. Inputs are associated with a finite number of discrete values, referred to as levels, so if each input has K levels and there are p inputs then there are K{sup P} possible distinct runs which constitute the K{sup P} factorial design space. The suggested size of p has been 35 to 50 so that even with K=2 the complete 2{sup P} factorial design space would not be run. Further, it is expected that the complexity of the simulation code and discrete levels possibly associated with equi-probable intervals from the input distribution make it desirable to consider more than 2 level inputs. Inputs levels of 5 and 7 have been investigated. In this paper, orthogonal array experiment designs, which are subsets of factorial designs also referred to as fractional factorial designs, are suggested as candidate experiments which provide meaningful basis for calculating and comparing R{sup 2} across subsets of inputs.

  19. Embryo selection in IVF: is polar body array comparative genomic hybridization accurate enough?

    PubMed

    Scriven, Paul N; Ogilvie, Caroline Mackie; Khalaf, Yacoub

    2012-04-01

    The emergence of the array comparative genomic hybridization technique (aCGH) is considered an advance in preimplantation genetic testing. Analysis of the recently published pilot study using polar body aCGH indicates that the test accuracy compares favourably with the fluorescence in situ hybridization technique although a substantial number of euploid zygotes are still likely to be excluded incorrectly. A sound argument against selection in principle has recently been published, based on accumulating evidence that potentially all embryos can now be cryopreserved and transferred in subsequent frozen replacement cycles without impairing pregnancy rates. We suggest that vitrification and serial transfer without testing are likely to give patients the best chance for a successful pregnancy, and avoid the use of an expensive technology. PMID:22328558

  20. Single electron tunneling in large scale nanojunction arrays with bisferrocene-nanoparticle hybrids.

    PubMed

    Karmakar, Shilpi; Kumar, Susmit; Marzo, Pasquale; Primiceri, Elisabetta; Di Corato, Riccardo; Rinaldi, Ross; Cozzi, Pier Giorgio; Bramanti, Alessandro Paolo; Maruccio, Giuseppe

    2012-04-01

    We report on the fabrication and single electron tunneling behaviour of large scale arrays of nanogap electrodes bridged by bisferrocene-gold nanoparticle hybrids (BFc-AuNP). Coulomb staircase was observed in the low temperature current-voltage curves measured on the junctions with asymmetric tunnel barriers. On the other hand, junctions with symmetric tunneling barrier exhibited mere nonlinear current voltage characteristics without discrete staircase. The experimental results agreed well with simulations based on the orthodox theory. The junction resistance showed thermally activated conduction behaviour at higher temperature. The overall voltage and temperature dependent results show that the transport behaviour of the large arrays of single particle devices obtained by a facile optical lithography and chemical etching process corresponds with the behaviour of single particle devices fabricated by other techniques like e-beam lithography and mechanical breaking methods. PMID:22370878

  1. Development of single-cell array for large-scale DNA fluorescence in situ hybridization

    PubMed Central

    Liu, Yingru; Kirkland, Brett; Shirley, James; Wang, Zhibin; Zhang, Peipei; Stembridge, Jacquelyn; Wong, Wilson; Takebayashi, Shin-ichiro; Gilbert, David M.; Lenhert, Steven

    2013-01-01

    DNA fluorescence in situ hybridization (FISH) is a powerful cytogenetic assay, but conventional sample-preparation methods for FISH do not support large-scale high-throughput data acquisition and analysis, which are potentially useful for several biomedical applications. To address this limitation, we have developed a novel FISH sample-preparation method based on generating a centimetre-sized cell array, in which all cells are precisely positioned and separated from their neighbours. This method is simple and easy and capable of patterning nonadherent human cells. We have successfully performed DNA FISH on the single-cell arrays, which facilitate analysis of FISH results with the FISH-FINDER computer program. PMID:23370691

  2. Phased Acoustic Array Measurements of a 5.75 Percent Hybrid Wing Body Aircraft

    NASA Technical Reports Server (NTRS)

    Burnside, Nathan J.; Horne, William C.; Elmer, Kevin R.; Cheng, Rui; Brusniak, Leon

    2016-01-01

    Detailed acoustic measurements of the noise from the leading-edge Krueger flap of a 5.75 percent Hybrid Wing Body (HWB) aircraft model were recently acquired with a traversing phased microphone array in the AEDC NFAC (Arnold Engineering Development Complex, National Full Scale Aerodynamics Complex) 40- by 80-Foot Wind Tunnel at NASA Ames Research Center. The spatial resolution of the array was sufficient to distinguish between individual support brackets over the full-scale frequency range of 100 to 2875 Hertz. For conditions representative of landing and take-off configuration, the noise from the brackets dominated other sources near the leading edge. Inclusion of flight-like brackets for select conditions highlights the importance of including the correct number of leading-edge high-lift device brackets with sufficient scale and fidelity. These measurements will support the development of new predictive models.

  3. Scattering and radiation analysis of three-dimensional cavity arrays via a hybrid finite element method

    NASA Technical Reports Server (NTRS)

    Jin, Jian-Ming; Volakis, John L.

    1992-01-01

    A hybrid numerical technique is presented for a characterization of the scattering and radiation properties of three-dimensional cavity arrays recessed in a ground plane. The technique combines the finite element and boundary integral methods and invokes Floquet's representation to formulate a system of equations for the fields at the apertures and those inside the cavities. The system is solved via the conjugate gradient method in conjunction with the Fast Fourier Transform (FFT) thus achieving an O(N) storage requirement. By virtue of the finite element method, the proposed technique is applicable to periodic arrays comprised of cavities having arbitrary shape and filled with inhomogeneous dielectrics. Several numerical results are presented, along with new measured data, which demonstrate the validity, efficiency, and capability of the technique.

  4. Hybrid preamplifier for solid state detectors on high energy experiments

    SciTech Connect

    Conte, M.; Zambra, A.

    1984-01-01

    This chapter reports on the study, development and production of hybrid preamplifiers for low noise data acquisition from solid state detectors. LABEN is devoted to the research, development and production of analog and digital instrumentation for nuclear, space and industrial applications. The hybrid preamplifiers are expected to reduce the size and cost in experiments requiring a high number of chains. LABEN has already produced a complete hybrid processor for data acquisition from radiation detectors in satellite experiments. Four types of preamplifiers are being developed: 1) a general purpose unit for Silicon detectors which can suit any type of application from telescope to microstrip detectors; 2) a low cost unit for microstrip Silicon detectors; 3) a special purpose preamplifier for very high counting rate applications with telescopes; and 4) a very low noise circuit for high energy applications of Germanium detectors.

  5. Magnetotransport experiments in two-dimensional electron gases exposed to electromagnetic hybrid superlattices

    NASA Astrophysics Data System (ADS)

    Schluck, Jakob; Fasbender, Stefan; Wissenberg, Stephan; Heinzel, Thomas; Pierz, Klaus; Schumacher, Hans-Werner; Kazazis, Dimitris; Gennser, Ulf

    Hybrid lateral superlattices composed of a square array of antidots and a periodic one-dimensional magnetic modulation are prepared in Ga[Al]As heterostructures. The two-dimensional electron gases exposed to these superlattices are characterized by magnetotransport experiments in various magnetic field configurations. Commensurability resonances as a function of a parallel external magnetic field are observed even in the absence of closed orbits, and interpreted with the help of numerical simulations based on the semiclassical Kubo model. In additional homogeneous perpendicular magnetic fields, quantum effects emerge, which can be attributed to the formation of closed quantized orbits.

  6. Streptococcus pneumoniae Supragenome Hybridization Arrays for Profiling of Genetic Content and Gene Expression

    PubMed Central

    Kadam, Anagha; Janto, Benjamin; Eutsey, Rory; Earl, Joshua P; Powell, Evan; Dahlgren, Margaret E; Hu, Fen Z; Ehrlich, Garth D; Hiller, N. Luisa

    2015-01-01

    There is extensive genomic diversity among Streptococcus pneumoniae isolates. Approximately half of the comprehensive set of genes in the species (the supragenome or pangenome) is present in all the isolates (core set), and the remaining is unevenly distributed among strains (distributed set). The Streptococcus pneumoniae Supragenome Hybridization (SpSGH) array provides coverage for an extensive set of genes and polymorphisms encountered within this species, capturing this genomic diversity. Further, the capture is quantitative. In this manner, the SpSGH array allows for both genomic and transcriptomic analyses of diverse S. pneumoniae isolates on a single platform. In this unit, we present the SpSGH array, and describe in detail its design and implementation for both genomic and transcriptomic analyses. The methodology can be applied to construction and modification of SpSGH array platforms, as well as applied to other bacterial species as long as multiple whole genome sequences are available that collectively capture the vast majority of the species supragenome. PMID:25641101

  7. Single electron tunneling in large scale nanojunction arrays with bisferrocene-nanoparticle hybrids

    NASA Astrophysics Data System (ADS)

    Karmakar, Shilpi; Kumar, Susmit; Marzo, Pasquale; Primiceri, Elisabetta; di Corato, Riccardo; Rinaldi, Ross; Cozzi, Pier Giorgio; Bramanti, Alessandro Paolo; Maruccio, Giuseppe

    2012-03-01

    We report on the fabrication and single electron tunneling behaviour of large scale arrays of nanogap electrodes bridged by bisferrocene-gold nanoparticle hybrids (BFc-AuNP). Coulomb staircase was observed in the low temperature current-voltage curves measured on the junctions with asymmetric tunnel barriers. On the other hand, junctions with symmetric tunneling barrier exhibited mere nonlinear current voltage characteristics without discrete staircase. The experimental results agreed well with simulations based on the orthodox theory. The junction resistance showed thermally activated conduction behaviour at higher temperature. The overall voltage and temperature dependent results show that the transport behaviour of the large arrays of single particle devices obtained by a facile optical lithography and chemical etching process corresponds with the behaviour of single particle devices fabricated by other techniques like e-beam lithography and mechanical breaking methods.We report on the fabrication and single electron tunneling behaviour of large scale arrays of nanogap electrodes bridged by bisferrocene-gold nanoparticle hybrids (BFc-AuNP). Coulomb staircase was observed in the low temperature current-voltage curves measured on the junctions with asymmetric tunnel barriers. On the other hand, junctions with symmetric tunneling barrier exhibited mere nonlinear current voltage characteristics without discrete staircase. The experimental results agreed well with simulations based on the orthodox theory. The junction resistance showed thermally activated conduction behaviour at higher temperature. The overall voltage and temperature dependent results show that the transport behaviour of the large arrays of single particle devices obtained by a facile optical lithography and chemical etching process corresponds with the behaviour of single particle devices fabricated by other techniques like e-beam lithography and mechanical breaking methods. Electronic supplementary

  8. Intelsat solar array coupon atomic oxygen flight experiment

    NASA Technical Reports Server (NTRS)

    Koontz, S.; King, G.; Dunnet, A.; Kirkendahl, T.; Linton, R.; Vaughn, J.

    1994-01-01

    A Hughes communications satellite (INTELSAT series) belonging to the INTELSAT Organization was marooned in low-Earth orbit (LEO) on March 14, 1990, following failure of the Titan launch vehicle third stage to separate properly. The satellite, INTELSAT 6, was designed for service in geosynchronous orbit and contains several materials that are potentially susceptible to attack by atomic oxygen. Analysis showed that direct exposure of the silver interconnects in the satellite photovoltaic array to atomic oxygen in LEO was the key materials issue. Available data on atomic oxygen degradation of silver are limited and show high variance, so solar array configurations of the INTELSAT 6 type and individual interconnects were tested in ground-based facilities and during STS-41 (Space Shuttle Discovery, October 1990) as part of the ISAC flight experiment. Several materials for which little or no flight data exist were also tested for atomic oxygen reactivity. Dry lubricants, elastomers, and polymeric and inorganic materials were exposed to an oxygen atom fluence of 1.1 x 10(exp 20) atoms cm(exp 2). Many of the samples were selected to support Space Station Freedom design and decision making. This paper provides an overview of the ISAC flight experiment and a brief summary of results. In addition to new data on materials not before flown, ISAC provided data supporting the decision to rescue INTELSAT 6, which was successfully undertaken in May 1992.

  9. Chemically modified nucleic acids as immunodetectable probes in hybridization experiments.

    PubMed Central

    Tchen, P; Fuchs, R P; Sage, E; Leng, M

    1984-01-01

    Guanine residues in nucleic acids can be modified by treatment with N-acetoxy-N-2-acetylaminofluorene and its 7-iodo derivative in an in vitro nonenzymatic reaction. The modified nucleic acids (ribo or deoxyribo, single or double stranded) are recognized by specific antibodies. They can be immunoprecipitated or used as probes in hybridization experiments and detected by immunochemical techniques. Images PMID:6374657

  10. Double Hypernuclei Experiment with Hybrid Emulsion Method at J-PARC

    NASA Astrophysics Data System (ADS)

    Ekawa, Hiroyuki

    Double hypernuclei are important probes to study the system with strangeness S = -2. Several emulsion experiments had been performed to search for them. We are planning a new experiment to search for double hypernuclei at the K1.8 beam line in the Hadron Experimental Facility (J-PARC E07 experiment). Ξ- tracks in the emulsion plates and SSD will be automatically connected by a hybrid method. The estimated Ξ- stopped statistics is 10 times as high as that of the KEK E373 experiment. Discoveries of 10 new double hypernuclear species are expected, which enable us to discuss binding energy in terms of mass number dependence. On the other hand, we will also observe X rays from Ξ- atoms with a germanium detector array installed close to theemulsion plates by tagging Ξ- stopped events. This will be the first measurement to give information on the Ξ- potential at the nuclear surface region.

  11. Experiences from the Roadrunner petascale hybrid systems

    SciTech Connect

    Kerbyson, Darren J; Pakin, Scott; Lang, Mike; Sancho Pitarch, Jose C; Davis, Kei; Barker, Kevin J; Peraza, Josh

    2010-01-01

    The combination of flexible microprocessors (AMD Opterons) with high-performing accelerators (IBM PowerXCell 8i) resulted in the extremely powerful Roadrunner system. Many challenges in both hardware and software were overcome to achieve its goals. In this talk we detail some of the experiences in achieving performance on the Roadrunner system. In particular we examine several implementations of the kernel application, Sweep3D, using a work-queue approach, a more portable Thread-building-blocks approach, and an MPI on the accelerator approach.

  12. Operation and test of hybridized silicon p-i-n arrays using open-source array control hardware and software

    NASA Astrophysics Data System (ADS)

    Moore, Andrew C.; Ninkov, Zoran; Burley, Gregory S.; Forrest, William J.; McMurtry, Craig W.; Avery, Lars E.

    2003-05-01

    A system for controlling and testing high-resolution non-destructive astronomical imagers was constructed using open-source components, both hardware and software. The open-source electronics design, originated by Carnegie Observatories (OCIW) for CCD cameras, was modified, assembled, and augmented with new circuitry which facilitates monitoring of voltages and currents. The electronics was run from Python user interface software based on a design from the University of Rochester. This new software utilized the Numarray and pyFITS modules developed at the Space Telescope Science Institute (STScI). Interfacing to the "dv" FITS image analysis package from the NASA IRTF was also implemented. Python (the STScI language of choice) was used as the primary language for systems integration, scripts for data acquisition, and scripts for data analysis. The DSP clocking software was a mixture of C and Motorola 56303 assembly. An interrupt-driven kernel-mode PCI device driver for Red Hat Linux was written in C, and used the PC processor and memory for image processing and acquisition. Two 1Κ × 1Κ Raytheon SB226-based hybridized silicon p-i-n arrays were operated and tested with the new system at temperatures as low as 10K. Signal path gain, node capacitance, well depth, dark current, and MTF measurements were made and are presented here.

  13. Telescience operations with the solar array module plasma interaction experiment

    NASA Technical Reports Server (NTRS)

    Wald, Lawrence W.; Bibyk, Irene K.

    1995-01-01

    The Solar Array Module Plasma Interactions Experiment (SAMPIE) is a flight experiment that flew on the Space Shuttle Columbia (STS-62) in March 1994, as part of the OAST-2 mission. The overall objective of SAMPIE was to determine the adverse environmental interactions within the space plasma of low earth orbit (LEO) on modern solar cells and space power system materials which are artificially biased to high positive and negative direct current (DC) voltages. The two environmental interactions of interest included high voltage arcing from the samples to the space plasma and parasitic current losses. High voltage arcing can cause physical damage to power system materials and shorten expected hardware life. parasitic current losses can reduce power system efficiency because electric currents generated in a power system drain into the surrounding plasma via parasitic resistance. The flight electronics included two programmable high voltage DC power supplies to bias the experiment samples, instruments to measure the surrounding plasma environment in the STS cargo bay, and the on-board data acquisition system (DAS). The DAS provided in-flight experiment control, data storage, and communications through the Goddard Space Flight Center (GSFC) Hitchhiker flight avionics to the GSFC Payload Operations Control Center (POCC). The DAS and the SAMPIE POCC computer systems were designed for telescience operations; this paper will focus on the experiences of the SAMPIE team regarding telescience development and operations from the GSFC POCC during STS-62. The SAMPIE conceptual development, hardware design, and system verification testing were accomplished at the NASA Lewis Research Center (LeRC). SAMPIE was developed under the In-Space Technology Experiment Program (IN-STEP), which sponsors NASA, industry, and university flight experiments designed to enable and enhance space flight technology. The IN-STEP Program is sponsored by the Office of Space Access and Technology (OSAT).

  14. Telescience operations with the solar array module plasma interaction experiment

    SciTech Connect

    Wald, L.W.; Bibyk, I.K.

    1995-09-01

    The Solar Array Module Plasma Interactions Experiment (SAMPIE) is a flight experiment that flew on the Space Shuttle Columbia (STS-62) in March 1994, as part of the OAST-2 mission. The overall objective of SAMPIE was to determine the adverse environmental interactions within the space plasma of low earth orbit (LEO) on modern solar cells and space power system materials which are artificially biased to high positive and negative direct current (DC) voltages. The two environmental interactions of interest included high voltage arcing from the samples to the space plasma and parasitic current losses. High voltage arcing can cause physical damage to power system materials and shorten expected hardware life. Parasitic current losses can reduce power system efficiency because electric currents generated in a power system drain into the surrounding plasma via parasitic resistance. The flight electronics included two programmable high voltage DC power supplies to bias the experiment samples, instruments to measure the surrounding plasma environment in the STS cargo bay, and the on-board data acquisition system (DAS). The DAS provided in-flight experiment control, data storage, and communications through the Goddard Space Flight Center (GSFC) Hitchhiker flight avionics to the GSFC Payload Operations Control Center (POCC). The DAS and the SAMPIE POCC computer systems were designed for telescience operations; this paper will focus on the experiences of the SAMPIE team regarding telescience development and operations from the GSFC POCC during STS-62. The SAMPIE conceptual development, hardware design, and system verification testing were accomplished at the NASA Lewis Research Center (LeRC). SAMPIE was developed under the In-Space Technology Experiment Program (IN-STEP), which sponsors NASA, industry, and university flight experiments designed to enable and enhance space flight technology.

  15. Hybridization modeling of oligonucleotide SNP arrays for accurate DNA copy number estimation

    PubMed Central

    Wan, Lin; Sun, Kelian; Ding, Qi; Cui, Yuehua; Li, Ming; Wen, Yalu; Elston, Robert C.; Qian, Minping; Fu, Wenjiang J

    2009-01-01

    Affymetrix SNP arrays have been widely used for single-nucleotide polymorphism (SNP) genotype calling and DNA copy number variation inference. Although numerous methods have achieved high accuracy in these fields, most studies have paid little attention to the modeling of hybridization of probes to off-target allele sequences, which can affect the accuracy greatly. In this study, we address this issue and demonstrate that hybridization with mismatch nucleotides (HWMMN) occurs in all SNP probe-sets and has a critical effect on the estimation of allelic concentrations (ACs). We study sequence binding through binding free energy and then binding affinity, and develop a probe intensity composite representation (PICR) model. The PICR model allows the estimation of ACs at a given SNP through statistical regression. Furthermore, we demonstrate with cell-line data of known true copy numbers that the PICR model can achieve reasonable accuracy in copy number estimation at a single SNP locus, by using the ratio of the estimated AC of each sample to that of the reference sample, and can reveal subtle genotype structure of SNPs at abnormal loci. We also demonstrate with HapMap data that the PICR model yields accurate SNP genotype calls consistently across samples, laboratories and even across array platforms. PMID:19586935

  16. Beam extraction experiment with field-emission arrays

    SciTech Connect

    Ishizuka, H.; Watanabe, A.; Shiho, M.

    1995-12-31

    An experimental project aimed to develop FEL drivers using a field-emission array is under way. The subject covers design and fabrication of novel micro-emitters, operation of FEAs, beam formation and emittance diagnostics. So far the generation of a focused beam has been demonstrated with an array of double-gated microemitters. Active control of FEAs has greatly improved the stability of the emission current. Large FEAs with an emitting area of up to 2 x 2 cm{sup 2} have been fabricated for the production of high-current beams. DC beams (1 - 5 keV < 100 {mu}A) extracted from Spindt cathodes were propagated over 1 m and projected on a fluorescent screen. Separate images of FEA tips were observed and emittance measurement has been carried out. The cathode is going to be replaced by a double-gated FEA to improve the beam quality. Pulsed extraction of high currents will also be tested, employing a non-gated FEA as the cathode of a 1 MV induction linac. Results of these experiments will be presented and perspectives concerning the FEA gun will be discussed.

  17. The Status and Recent Results of the Telescope Array Experiment

    NASA Astrophysics Data System (ADS)

    Yamazaki, Katsuya

    The Telescope Array (TA) is a cosmic ray observatory of the largest aperture in the northern hemisphere, located in a desert in the western part of Utah, U.S.A., to explore the origin of ultrahigh energy cosmic rays, photons, and neutrinos. The TA employs two types of detectors to observe air showers generated by cosmic rays in the atmosphere: the first is a "surface detector (SD)" of scintillation counters to measure shower particles on the ground, and the second is a "fluorescence detector (FD)" of telescopes installed in three stations to observe fluorescence light, caused by air shower particles, from the atmosphere above the SD array. The TA detectors have been in routine operation since May 2008. We measured the energy spectrum of cosmic rays with energy greater than 1018 eV from our first 4-year data. We found a clear suppression of comic ray intensity above 5 × 1019 eV. This feature is consistent with a theoretical prediction that cosmic rays lose energies due to interaction with cosmic microwave background photons during propagation in the intergalactic space. In this talk, We will present the status of the TA experiment and the recent results, including the energy spectrum, study of the primary mass composition, and searches for anisotropies in the arrival directions. We also briefly describe plans for further extensions.

  18. The First Experiment with VLBI-GPS Hybrid System

    NASA Technical Reports Server (NTRS)

    Kwak, Younghee; Kondo, Tetsuro; Gotoh, Tadahiro; Amagai, Jun; Takiguchi, Hiroshi; Sekido, Mamoru; Ichikawa, Ryuichi; Sasao, Tetsuo; Cho, Jungho; Kim, Tuhwan

    2010-01-01

    In this paper, we introduce our GPS-VLBI hybrid system and show the results of the first experiment which is now under way. In this hybrid system, GPS signals are captured by a normal GPS antenna, down-converted to IF signals, and then sampled by the VLBI sampler VSSP32 developed by NICT. The sampled GPS data are recorded and correlated in the same way as VLBI observation data. The correlator outputs are the group delay and the delay rate. Since the whole system uses the same frequency standard, many sources of systematic errors are common between the VLBI system and the GPS system. In this hybrid system, the GPS antenna can be regarded as an additional VLBI antenna having multiple beams towards GPS satellites. Therefore, we expect that this approach will provide enough data to improve zenith delay estimates and geodetic results.

  19. The Photovoltaic Array Space Power plus Diagnostics (PASP Plus) Flight Experiment

    NASA Technical Reports Server (NTRS)

    Piszczor, Michael F.; Curtis, Henry B.; Guidice, Donald A.; Severance, Paul S.

    1992-01-01

    An overview of the Photovoltaic Array Space Power Plus Diagnostics (PASP Plus) flight experiment is presented in outline and graphic form. The goal of the experiment is to test a variety of photovoltaic cell and array technologies under various space environmental conditions. Experiment objectives, flight hardware, experiment control and diagnostic instrumentation, and illuminated thermal vacuum testing are addressed.

  20. PV-Diesel Hybrid SCADA Experiment Network Design

    NASA Technical Reports Server (NTRS)

    Kalu, Alex; Durand, S.; Emrich, Carol; Ventre, G.; Wilson, W.; Acosta, R.

    1999-01-01

    The essential features of an experimental network for renewable power system satellite based supervisory, control and data acquisition (SCADA) are communication links, controllers, diagnostic equipment and a hybrid power system. Required components for implementing the network consist of two satellite ground stations, to satellite modems, two 486 PCs, two telephone receivers, two telephone modems, two analog telephone lines, one digital telephone line, a hybrid-power system equipped with controller and a satellite spacecraft. In the technology verification experiment (TVE) conducted by Savannah State University and Florida Solar Energy Center, the renewable energy hybrid system is the Apex-1000 Mini-Hybrid which is equipped with NGC3188 for user interface and remote control and the NGC2010 for monitoring and basic control tasks. This power system is connected to a satellite modem via a smart interface, RS232. Commands are sent to the power system control unit through a control PC designed as PC1. PC1 is thus connected to a satellite model through RS232. A second PC, designated PC2, the diagnostic PC is connected to both satellite modems via separate analog telephone lines for checking modems'health. PC2 is also connected to PC1 via a telephone line. Due to the unavailability of a second ground station for the ACTS, one ground station is used to serve both the sending and receiving functions in this experiment. Signal is sent from the control PC to the Hybrid system at a frequency f(sub 1), different from f(sub 2), the signal from the hybrid system to the control PC. f(sub l) and f(sub 2) are sufficiently separated to avoid interference.

  1. Detection limit of intragenic deletions with targeted array comparative genomic hybridization

    PubMed Central

    2013-01-01

    Background Pathogenic mutations range from single nucleotide changes to deletions or duplications that encompass a single exon to several genes. The use of gene-centric high-density array comparative genomic hybridization (aCGH) has revolutionized the detection of intragenic copy number variations. We implemented an exon-centric design of high-resolution aCGH to detect single- and multi-exon deletions and duplications in a large set of genes using the OGT 60 K and 180 K arrays. Here we describe the molecular characterization and breakpoint mapping of deletions at the smaller end of the detectable range in several genes using aCGH. Results The method initially implemented to detect single to multiple exon deletions, was able to detect deletions much smaller than anticipated. The selected deletions we describe vary in size, ranging from over 2 kb to as small as 12 base pairs. The smallest of these deletions are only detectable after careful manual review during data analysis. Suspected deletions smaller than the detection size for which the method was optimized, were rigorously followed up and confirmed with PCR-based investigations to uncover the true detection size limit of intragenic deletions with this technology. False-positive deletion calls often demonstrated single nucleotide changes or an insertion causing lower hybridization of probes demonstrating the sensitivity of aCGH. Conclusions With optimizing aCGH design and careful review process, aCGH can uncover intragenic deletions as small as dozen bases. These data provide insight that will help optimize probe coverage in array design and illustrate the true assay sensitivity. Mapping of the breakpoints confirms smaller deletions and contributes to the understanding of the mechanism behind these events. Our knowledge of the mutation spectra of several genes can be expected to change as previously unrecognized intragenic deletions are uncovered. PMID:24304607

  2. The ETscope Ground Array for the ULTRA Experiment

    NASA Astrophysics Data System (ADS)

    Chauvin, J.; Fava, L.; Lebrun, L.; Teyssier, D.; Vallania, P.; Vigorito, C.; EUSO Collaboration

    2003-07-01

    The ETscope detector designed for the ULTRA experiment is a small array made of 7 particle detection stations. operating simultaneously with an optical telescope it ˇ detects the Extensive Air Showers in coincidence with the Cerenkov light, diffused by the impact on the ground. The main goal of the detector is the characterization of the impinging shower by the measurement of size and arrival direction. These informations, together with the UV light measurement and an accurate MC simulation, will allow the determination of the diffusing features of the ground. Since it must be placed on different surfaces including sea, it has been optimized as portable, floating and waterpro of detector. First test has been performed during October 2002 at Mont-Cenis in the Alps region, at the France-Italy border. Detector performances and preliminary results will be discussed here.

  3. Fabrication of hybrid nanostructured arrays using a PDMS/PDMS replication process.

    PubMed

    Hassanin, H; Mohammadkhani, A; Jiang, K

    2012-10-21

    In the study, a novel and low cost nanofabrication process is proposed for producing hybrid polydimethylsiloxane (PDMS) nanostructured arrays. The proposed process involves monolayer self-assembly of polystyrene (PS) spheres, PDMS nanoreplication, thin film coating, and PDMS to PDMS (PDMS/PDMS) replication. A self-assembled monolayer of PS spheres is used as the first template. Second, a PDMS template is achieved by replica moulding. Third, the PDMS template is coated with a platinum or gold layer. Finally, a PDMS nanostructured array is developed by casting PDMS slurry on top of the coated PDMS. The cured PDMS is peeled off and used as a replica surface. In this study, the influences of the coating on the PDMS topography, contact angle of the PDMS slurry and the peeling off ability are discussed in detail. From experimental evaluation, a thickness of at least 20 nm gold layer or 40 nm platinum layer on the surface of the PDMS template improves the contact angle and eases peeling off. The coated PDMS surface is successfully used as a template to achieve the replica with a uniform array via PDMS/PDMS replication process. Both the PDMS template and the replica are free of defects and also undistorted after demoulding with a highly ordered hexagonal arrangement. In addition, the geometry of the nanostructured PDMS can be controlled by changing the thickness of the deposited layer. The simplicity and the controllability of the process show great promise as a robust nanoreplication method for functional applications. PMID:22868401

  4. EARLY EXPERIENCE WITH A HYBRID PROCESSOR: K-MEANS CLUSTERING

    SciTech Connect

    M. GOKHALE; ET AL

    2001-02-01

    We discuss hardware/software coprocessing on a hybrid processor for a compute- and data-intensive hyper-spectral imaging algorithm, K-Means Clustering. The experiments are performed on the Altera Excalibur board using the soft IP core 32-bit NIOS RISC processor. In our experiments, we compare performance of the sequential algorithm with two different accelerated versions. We consider granularity and synchronization issues when mapping an algorithm to a hybrid processor. Our results show that on the Excalibur NIOS, a 15% speedup can be achieved over the sequential algorithm on images with 8 spectral bands where the pixels are divided into 8 categories. Speedup is limited by the communication cost of transferring data from external memory through the NIOS processor to the customized circuits. Our results indicate that future hybrid processors must either (1) have a clock rate 10X the speed of the configurable logic circuits or (2) include dual port memories that both the processor and configurable logic can access. If either of these conditions is met, the hybrid processor will show a factor of 10 speedup over the sequential algorithm. Such systems will combine the convenience of conventional processors with the speed of configurable logic.

  5. Data Analysis for Sequencing by Hybridization (SBH) Experiments

    Energy Science and Technology Software Center (ESTSC)

    1995-11-28

    SCORES is user friendly software designed to analyze data from SBH (Sequencing By Hybridization) experiments. In these ANL experiments DNA samples are spotted on a nylon membrane and hybridized with radioactivity labeled oligonucleotide probes. An image analysis program (DOTS) calculates a raw value for each DNA dot from images generated by the Molecular Dynamics Phosphorimager. SCORES reads in the DOTS output for each hybridization done for a particular filter. The data for each probe ismore » normalized against a mass probe and scaled properly. These values from 100 or more probes are then used to compute the distance (i.e., degree of similarity) between any two clones on the filter. These calculated distances define clusters of similar clones (cDNA)or contigs (genomic DNA). Histograms of the data at each stage of analysis to establish thresholds for further steps. SCORES generates various statistical tables to evaluate the quality of spotting, hybridization of filters, and of individual dots.« less

  6. Kinetics of Oligonucleotide Hybridization to DNA Probe Arrays on High-Capacity Porous Silica Substrates

    PubMed Central

    Glazer, Marc I.; Fidanza, Jacqueline A.; McGall, Glenn H.; Trulson, Mark O.; Forman, Jonathan E.; Frank, Curtis W.

    2007-01-01

    We have investigated the kinetics of DNA hybridization to oligonucleotide arrays on high-capacity porous silica films that were deposited by two techniques. Films created by spin coating pure colloidal silica suspensions onto a substrate had pores of ∼23 nm, relatively low porosity (35%), and a surface area of 17 times flat glass (for a 0.3-μm film). In the second method, latex particles were codeposited with the silica by spin coating and then pyrolyzed, which resulted in larger pores (36 nm), higher porosity (65%), and higher surface area (26 times flat glass for a 0.3-μm film). As a result of these favorable properties, the templated silica hybridized more quickly and reached a higher adsorbed target density (11 vs. 8 times flat glass at 22°C) than the pure silica. Adsorption of DNA onto the high-capacity films is controlled by traditional adsorption and desorption coefficients, as well as by morphology factors and transient binding interactions between the target and the probes. To describe these effects, we have developed a model based on the analogy to diffusion of a reactant in a porous catalyst. Adsorption values (ka, kd, and K) measured on planar arrays for the same probe/target system provide the parameters for the model and also provide an internally consistent comparison for the stability of the transient complexes. The interpretation of the model takes into account factors not previously considered for hybridization in three-dimensional films, including the potential effects of heterogeneous probe populations, partial probe/target complexes during diffusion, and non-1:1 binding structures. The transient complexes are much less stable than full duplexes (binding constants for full duplexes higher by three orders of magnitude or more), which may be a result of the unique probe density and distribution that is characteristic of the photolithographically patterned arrays. The behavior at 22°C is described well by the predictive equations for

  7. Global synchronization in arrays of coupled Lurie systems with both time-delay and hybrid coupling

    NASA Astrophysics Data System (ADS)

    Li, Tao; Song, Aiguo; Fei, Shumin; Wang, Ting

    2011-01-01

    In this paper, we propose and study an array of coupled delayed Lurie systems with hybrid coupling, which is composed of constant coupling, state delay coupling, and distributed delay coupling. Together with Lyapunov-Krasovskii functional method and Kronecker product properties, two novel synchronization criteria are presented within linear matrix inequalities based on generalized convex combination, in which these conditions are heavily dependent on the upper and lower bounds of state delay and distributed one. Through adjusting inner coupling matrix parameters in the derived results, we can realize the designing and applications of the addressed systems by referring to Matlab LMI Toolbox. The efficiency and applicability of the proposed criteria can be demonstrated by three numerical examples with simulations.

  8. Hybrid sample-inverted reflow and soft-lithography technique for fabrication of conicoid microlens arrays.

    PubMed

    He, Miao; Yuan, Xiaocong; Bu, Jing; Cheong, Wai Chye

    2005-07-01

    We report a cost-effective fabrication method, with a combination of the sample-inverted reflow technique and the soft-lithography replication method, to fabricate conicoid refractive microlens arrays (MLAs), including hyperboloid, paraboloid, and ellipsoid MLAs in inorganic-organic hybrid SiO2-ZrO2 solgel material. The fabrication procedures involve two basic steps. First, a master of the conicoid MLA was made in photoresist by the sample-inverted reflow technique. Second, we built a negative mold of the master by casting polydimethylsiloxane (PDMS) onto a silicone elastomer against the master, and then the profile was imprinted onto the solgel glass. As a result, the fabricated solgel MLAs have been obtained with excellent smooth profiles, having negligible discrepancies from the profiles of ideal conicoid MLAs. PMID:16004061

  9. Hybrid sample-inverted reflow and soft-lithography technique for fabrication of conicoid microlens arrays

    NASA Astrophysics Data System (ADS)

    He, Miao; Yuan, Xiaocong; Bu, Jing; Chye Cheong, Wai

    2005-07-01

    We report a cost-effective fabrication method, with a combination of the sample-inverted reflow technique and the soft-lithography replication method, to fabricate conicoid refractive microlens arrays (MLAs), including hyperboloid, paraboloid, and ellipsoid MLAs in inorganic-organic hybrid SiO2-ZrO2 solgel material. The fabrication procedures involve two basic steps. First, a master of the conicoid MLA was made in photoresist by the sample-inverted reflow technique. Second, we built a negative mold of the master by casting polydimethylsiloxane (PDMS) onto a silicone elastomer against the master, and then the profile was imprinted onto the solgel glass. As a result, the fabricated solgel MLAs have been obtained with excellent smooth profiles, having negligible discrepancies from the profiles of ideal conicoid MLAs.

  10. A Hybrid Computational Model for Ultrasound Phased-Array Heating in Presence of Strongly Scattering Obstacles

    PubMed Central

    Botros, Youssry Y.; VanBaren, Philip; Ebbini, Emad S.

    2010-01-01

    A computationally efficient hybrid ray–physical optics (HRPO) model is presented for the analysis and synthesis of multiple-focus ultrasound heating patterns through the human rib cage. In particular, a ray method is used to propagate the ultrasound fields from the source to the frontal plane of the rib cage. The physical-optics integration method is then employed to obtain the intensity pattern inside the rib cage. The solution of the matrix system is carried out by using the pseudo inverse technique to synthesize the desired heating pattern. The proposed technique guides the fields through the intercostal spacings between the solid ribs and, thus, minimal intensity levels are observed over the solid ribs. This simulation model allows for the design and optimization of large-aperture phased-array applicator systems for noninvasive ablative thermal surgery in the heart and liver through the rib cage. PMID:9353983

  11. Development of a gallium-doped germanium far-infrared photoconductor direct hybrid two-dimensional array.

    PubMed

    Fujiwara, Mikio; Hirao, Takanori; Kawada, Mitsunobu; Shibai, Hiroshi; Matsuura, Shuji; Kaneda, Hidehiro; Patrashin, Mikhail; Nakagawa, Takao

    2003-04-20

    To our knowledge, we are the first to successfully report a direct hybrid two-dimensional (2D) detector array in the far-infrared region. Gallium-doped germanium (Ge:Ga) has been used extensively to produce sensitive far-infrared detectors with a cutoff wavelength of approximately equal to 110 microm (2.7 THz). It is widely used in the fields of astronomy and molecular and solid spectroscopy. However, Ge:Ga photoconductors must be cooled below 4.2 K to reduce thermal noise, and this operating condition makes it difficult to develop a large format array because of the need for a warm amplifier. Development of Ge:Ga photoconductor arrays to take 2D terahertz images is now an important target in such research fields as space astronomy. We present the design of a 20 x 3 Ge:Ga far-infrared photoconductor array directly hybridized to a Si p-type metal-oxide-semiconductor readout integrated circuit using indium-bump technology. The main obstacles in creating this 2D array were (1) fabricating a monolithic Ge:Ga 2D array with a longitudinal configuration, (2) developing a cryogenic capacitive transimpedance amplifer, and (3) developing a technology for connecting the detector to the electronics. With this technology, a prototype Ge:Ga photoconductor with a direct hybrid structure has shown a responsivity as high as 14.6 A/W and a minimum detectable power of 5.6 x 10(-17) W for an integration time of 0.14 s when it was cooled to 2.1 K. Its noise is limited by the readout circuit with 20 microV/Hz(1/2) at 1 Hz. Vibration and cooling tests demonstrated that this direct hybrid structure is strong enough for spaceborne instruments. This detector array will be installed on the Japanese infrared satellite ASTRO-F. PMID:12716158

  12. Analysis of MMIC arrays for use in the ACTS Aero Experiment

    NASA Technical Reports Server (NTRS)

    Zimmerman, M.; Lee, R.; Rho, E.; Zaman, Z.

    1993-01-01

    The Aero Experiment is designed to demonstrate communication from an aircraft to an Earth terminal via the ACTS. This paper describes the link budget and antenna requirements for a 4.8 kbps full-duplex voice link at Ka-Band frequencies. Three arrays, one transmit array developed by TI and two receive arrays developed by GE and Boeing, were analyzed. The predicted performance characteristics of these arrays are presented and discussed in the paper.

  13. Real-time biomimetic Central Pattern Generators in an FPGA for hybrid experiments

    PubMed Central

    Ambroise, Matthieu; Levi, Timothée; Joucla, Sébastien; Yvert, Blaise; Saïghi, Sylvain

    2013-01-01

    This investigation of the leech heartbeat neural network system led to the development of a low resources, real-time, biomimetic digital hardware for use in hybrid experiments. The leech heartbeat neural network is one of the simplest central pattern generators (CPG). In biology, CPG provide the rhythmic bursts of spikes that form the basis for all muscle contraction orders (heartbeat) and locomotion (walking, running, etc.). The leech neural network system was previously investigated and this CPG formalized in the Hodgkin–Huxley neural model (HH), the most complex devised to date. However, the resources required for a neural model are proportional to its complexity. In response to this issue, this article describes a biomimetic implementation of a network of 240 CPGs in an FPGA (Field Programmable Gate Array), using a simple model (Izhikevich) and proposes a new synapse model: activity-dependent depression synapse. The network implementation architecture operates on a single computation core. This digital system works in real-time, requires few resources, and has the same bursting activity behavior as the complex model. The implementation of this CPG was initially validated by comparing it with a simulation of the complex model. Its activity was then matched with pharmacological data from the rat spinal cord activity. This digital system opens the way for future hybrid experiments and represents an important step toward hybridization of biological tissue and artificial neural networks. This CPG network is also likely to be useful for mimicking the locomotion activity of various animals and developing hybrid experiments for neuroprosthesis development. PMID:24319408

  14. Lower Hybrid Current Drive Experiments in Alcator C-Mod

    SciTech Connect

    J.R. Wilson, S. Bernabei, P. Bonoli, A. Hubbard, R. Parker, A. Schmidt, G. Wallace, J. Wright, and the Alcator C-Mod Team

    2007-10-09

    A Lower Hybrid Current Drive (LHCD) system has been installed on the Alcator C-MOD tokamak at MIT. Twelve klystrons at 4.6 GHz feed a 4x22 waveguide array. This system was designed for maximum flexibility in the launched parallel wave-number spectrum. This flexibility allows tailoring of the lower hybrid deposition under a variety of plasma conditions. Power levels up to 900 kW have been injected into the tokomak. The parallel wave number has been varied over a wide range, n|| ~ 1.6–4. Driven currents have been inferred from magnetic measurements by extrapolating to zero loop voltage and by direct comparison to Fisch-Karney theory, yielding an efficiency of n20IR/P ~ 0.3. Modeling using the CQL3D code supports these efficiencies. Sawtooth oscillations vanish, accompanied with peaking of the electron temperature (Te0 rises from 2.8 to 3.8 keV). Central q is inferred to rise above unity from the collapse of the sawtooth inversion radius, indicating off-axis cd as expected. Measurements of non-thermal x-ray and electron cyclotron emission confirm the presence of a significant fast electron population that varies with phase and plasma density. The x-ray emission is observed to be radialy broader than that predicted by simple ray tracing codes. Possible explanations for this broader emission include fast electron diffusion or broader deposition than simple ray tracing predictions (perhaps due to diffractive effects).

  15. Hybrid tandem solar cell enhanced by a metallic hole-array as the intermediate electrode.

    PubMed

    Zhang, Xuanru; Huang, Qiuping; Hu, Jigang; Knize, Randy J; Lu, Yalin

    2014-10-20

    A metallic hole-array structure was inserted into a tandem solar cell structure as an intermediate electrode, which allows a further fabrication of a novel and efficient hybrid organic-inorganic tandem solar cell. The inserted hole-array layer reflects the higher-energy photons back to the top cell, and transmits lower-energy photons to the bottom cell via the extraordinary optical transmission (EOT) effect. In this case light absorption in both top and bottom subcells can be simultaneously enhanced via both structural and material optimizations. Importantly, this new design could remove the constraints of requiring lattice-matching and current-matching between the used two cascaded subcells in a conventional tandem cell structure, and therefore, the tunnel junction could be no longer required. As an example, a novel PCBM/CIGS tandem cell was designed and investigated. A systematic modeling study was made on the structural parameter tuning, with the period ranging from a few hundreds nanometers to over one micrometer. Surface plasmon polaritons, magnetic plasmon polaritons, localized surface plasmons, and optical waveguide modes were found to participate in the EOT and the light absorption enhancement. Impressively, more than 40% integrated power enhancement can be achieved in a variable structural parameter range. PMID:25607297

  16. Composition of Ultra High Energy Cosmic Rays Observed by Telescope Array in Hybrid Mode

    NASA Astrophysics Data System (ADS)

    Hanlon, William; Telescope Array Collaboration

    2016-03-01

    The energy spectrum of cosmic rays exhibits several important features such as the knee (E ~10 15 . 5 eV), ankle (E ~10 18 . 7 eV), and high energy suppression (E ~10 19 . 8 eV). Cosmic ray chemical composition is the key to understanding their galactic and extragalactic sources as well as the origin of particle production and acceleration mechanisms. Energy dependent chemical composition is a fundamental input for models of cosmic ray sources and interstellar transport which may lead to competing explanations of the observed spectral features. Understanding composition will therefore allow one to distinguish between the different scenarios of cosmic ray origin, a decades old problem in astrophysics. In this talk we will describe measurements of ultra high energy cosmic ray composition performed by Telescope Array (TA) using Xmax measured in extended air showers (EAS) simultaneously observed by the TA surface array and TA fluorescence stations (called hybrid mode). Showers with primary energies above 1018 eV will be considered. We will also discuss improved methods of comparing the measured composition to EAS models.

  17. Large 2D-arrays of size-controllable silver nanoparticles prepared by hybrid deposition

    NASA Astrophysics Data System (ADS)

    Dieu Thuy Ung, Thi; Hoa Nguyen, Thi; Liem Nguyen, Quang

    2016-09-01

    Two main results are presented in this paper. (i) Silver nanoparticles (AgNPs) with uniform size-distribution and controllability in the range of 20–50 nm were synthesized by seeding and growing at ambient conditions. The single-crystal Ag nano-seeds were created by reduction of AgNO3 in presence of citrate surfactant at 70 °C. Then, importantly, the fresh AgCl precursor was used in the presence of polyvinylpyrrolidone to adjust the reaction rate with ascorbic acid to generate Ag for growing on the surface of single-crystal Ag nano-seeds. The AgNPs size could be well-controlled by varying the amount of Ag nano-seeds while keeping the AgCl precursor concentration to be constant. (ii) The large 2D-arrays with homogeneous and dense monolayers of AgNPs were prepared on ITO substrates by hybrid method, in which the key technological point is the surface functionalization of AgNPs using mixed alkanethiols (dodecanethiol:octadecanethiol = 6:1). We have used the fabricated 2D-arrays from the 50 nm AgNPs as a surface enhanced Raman scattering substrate to take the Raman scattering spectra of rhodamine B (RhB), glucose and viral pathogen (H5N1) at very low concentrations of 10‑10 M, 10‑12 M and 4 ng μl‑1, respectively.

  18. SKS splitting beneath the MAGIC FlexArray experiment

    NASA Astrophysics Data System (ADS)

    Aragon, J. C.; Long, M. D.; Benoit, M. H.; Kirby, E.; King, S. D.

    2015-12-01

    The Mid-Atlantic Geophysical Integrative Collaboration (MAGIC) is an EarthScope and GeoPRISMS-funded project that involves a collaborative effort among seismologists, geodynamicists, and geomorphologists to understand the relationships among surface processes, crustal and lithospheric structure, and deep mantle flow beneath eastern North America. The eastern passive continental margin has been modified by multiple episodes of orogenesis and rifting through several cycles of supercontinent assembly and breakup over the past 1.3 billion years of Earth history. The MAGIC Flexible Array broadband seismic deployment began in October 2013, with the main phase of the deployment taking place in October 2014. As of summer 2015 the experiment had 27 stations running; the deployment will demobilize in October 2016. We have investigated splitting of SKS phases measured at MAGIC stations during the early stages of the deployment. As illustrated by this presentation, stations located in the Appalachian Mountains, present fast splitting directions parallel to the strike of the Appalachian range, with delay times of approximately 1 sec. At stations to the east and west of the high topography, we find more complicated splitting patterns, with fast directions that vary over short length scales and a large number of null SKS arrivals over a range of backazimuths. These observations suggest a significant contribution to SKS splitting from anisotropy in the lithospheric upper mantle in our study region.

  19. Lower Hybrid Coupling Experiments on Alcator C-Mod

    SciTech Connect

    Wallace, G.; Bonoli, P.; Parisot, A.; Parker, R.; Schmidt, A.; Wilson, J. R.

    2007-09-28

    The Alcator C-Mod Lower Hybrid Current Drive experiment launches RF waves at 4.6 GHz via 4 rows of 22 phased waveguides. Forward and reflected power is measured with 156 directional couplers in the launcher structure. Langmuir probes mounted to the front of the antenna monitor density at the plasma edge and act as RF probes for the observation of parametric decay instability. Measurements of the coupling of lower hybrid waves have been performed at power levels approaching 1 MW. Edge density, launched n{sub parallel} spectrum, and plasma shape have been adjusted to optimize coupling in L-mode plasmas. Experimentally observed coupling results will be compared to simulations from the Brambilla Grill code [1].

  20. Selection of oligonucleotide probes and experimental conditions for multiplex hybridization experiments.

    PubMed

    Bains, W

    1994-01-01

    Different DNA probes hybridize under different conditions. I examine the constraints of the design of oligonucleotide probes that are meant to hybridize to different unique sites in human genomic DNA under a single set of hybridization conditions as a parallel array. In 522 kb of human genomic DNA, 75% of 12-base and 89% of 22-base are unique, as opposed to 90% and 100% as expected of unstructured DNA, and this is not due solely to repetitive elements in the DNA. Hybridization in TMAC to reduce A+T content effects on melting temperature allows only 90% of unique targets to be hybridized under one set of conditions if a 2 degrees C difference between matched and mismatched sequences is required. Standard hybridization conditions allow no more than 60% of unique probes to be used together. This suggests that probe, hybridization conditions, and instrument design for multiple-probe hybridization applications will be harder than previously suggested. PMID:7803130

  1. A 3-D spectral-element and frequency-wave number hybrid method for high-resolution seismic array imaging

    NASA Astrophysics Data System (ADS)

    Tong, Ping; Komatitsch, Dimitri; Tseng, Tai-Lin; Hung, Shu-Huei; Chen, Chin-Wu; Basini, Piero; Liu, Qinya

    2014-10-01

    We present a three-dimensional (3-D) hybrid method that interfaces the spectral-element method (SEM) with the frequency-wave number (FK) technique to model the propagation of teleseismic plane waves beneath seismic arrays. The accuracy of the resulting 3-D SEM-FK hybrid method is benchmarked against semianalytical FK solutions for 1-D models. The accuracy of 2.5-D modeling based on 2-D SEM-FK hybrid method is also investigated through comparisons to this 3-D hybrid method. Synthetic examples for structural models of the Alaska subduction zone and the central Tibet crust show that this method is capable of accurately capturing interactions between incident plane waves and local heterogeneities. This hybrid method presents an essential tool for the receiver function and scattering imaging community to verify and further improve their techniques. These numerical examples also show the promising future of the 3-D SEM-FK hybrid method in high-resolution regional seismic imaging based on waveform inversions of converted/scattered waves recorded by seismic array.

  2. Characterization of novel Hamamatsu Multi Pixel Photon Counter (MPPC) arrays for the GlueX experiment

    SciTech Connect

    Soto, Orlando; Rojas, Rimsky; Kuleshov, Sergey V.; Hakobyan, Hayk; Toro, Alam; Brooks, William K.

    2013-12-01

    The novel Hamamatsu Multi Pixel Photon Counter Array S12045(X) is an array of 16 individual MPPCs (3x3 mm{sup 2}) (further in the paper MPPC array channel) each with 3600 G-APD (Geiger-mode Avalanche Photodiodes) pixels (50x50 [{micro}m{sup 2}]). Each MPPC in the array works with its individual reverse bias voltage mode (around 70 V). The paper summarizes the characterization process of MPPC arrays used in GlueX experiment (Hall D, Jefferson Lab). We studied the main features of each MPPC array channel for 2800 MPPC arrays at different temperatures. Two measurement stations were built to extract gain, breakdown voltage, photo detection efficiency (PDE), optical crosstalk and dark rate for each MPPC array channel. The hardware and the data analysis are described, which includes new analytical expressions to obtain the mean number of photo-electrons and optical crosstalk. The dynamical behavior of characterization parameters is presented as well.

  3. Isolation of disseminated neuroblastoma cells from bone marrow aspirates for pretreatment risk assessment by array comparative genomic hybridization.

    PubMed

    Vandewoestyne, Mado; Kumps, Candy; Swerts, Katrien; Menten, Björn; Lammens, Tim; Philippé, Jan; De Preter, Katleen; Laureys, Geneviève; Van Roy, Nadine; Speleman, Frank; Deforce, Dieter

    2012-03-01

    In neuroblastoma, tumor biopsies are used for prognostic evaluation and risk assessment by molecular genetic analyses such as fluorescence in situ hybridization (FISH) and array comparative genomic hybridization (array CGH). Analysis of primary tumors by array CGH can be hampered by the lack of sufficient tumor cells due to small biopsy size or availability of invaded bone marrow only. Given the importance of accurate assessment of genetic alterations in the diagnostic work-up of patients with neuroblastoma, we evaluated the possibility to analyze bone marrow metastases in patients with disseminated disease. Disseminated neuroblastoma cells were isolated from bone marrow aspirates by using either laser capture microdissection (LCM) or magnetic activated cell sorting (MACS). The array CGH profiles of these isolated metastases were compared to array CGH profiles and/or FISH data of the corresponding primary tumor. Here, we show that the major recurrent DNA copy number alterations detected in primary neuroblastoma tumors (i.e., 1p, 3p and 11q deletion, 17q gain and MYCN amplification) can be detected, with high sensitivity and specificity, in the disseminated neuroblastoma cells isolated from the bone marrow aspirates, using an array platform with high coverage for these regions. Moreover, we demonstrate that for archived material, for example, for retrospective studies, LCM is the method of choice, while for fresh bone marrow aspirates, acquired at the time of diagnosis, MACS is superior. PMID:21484798

  4. Apollo lunar surface experiments package. Apollo 17 ALSEP (array E) familiarization course handout

    NASA Technical Reports Server (NTRS)

    1972-01-01

    The familiarization course for the Apollo 17 ALSEP (ARRAY E) is presented. The subjects discussed are: (1) power and data subsystems, (2) lunar surface gravimeter, (3) lunar mass spectrometer, (4) lunar seismic profiling experiment, and (5) heat flow experiment.

  5. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository.

    PubMed

    Edgar, Ron; Domrachev, Michael; Lash, Alex E

    2002-01-01

    The Gene Expression Omnibus (GEO) project was initiated in response to the growing demand for a public repository for high-throughput gene expression data. GEO provides a flexible and open design that facilitates submission, storage and retrieval of heterogeneous data sets from high-throughput gene expression and genomic hybridization experiments. GEO is not intended to replace in house gene expression databases that benefit from coherent data sets, and which are constructed to facilitate a particular analytic method, but rather complement these by acting as a tertiary, central data distribution hub. The three central data entities of GEO are platforms, samples and series, and were designed with gene expression and genomic hybridization experiments in mind. A platform is, essentially, a list of probes that define what set of molecules may be detected. A sample describes the set of molecules that are being probed and references a single platform used to generate its molecular abundance data. A series organizes samples into the meaningful data sets which make up an experiment. The GEO repository is publicly accessible through the World Wide Web at http://www.ncbi.nlm.nih.gov/geo. PMID:11752295

  6. Silicon PIN diode hybrid arrays for charged particle detection: Building blocks for vertex detectors at the SSC

    SciTech Connect

    Kramer, G.; Gaalema, S.; Shapiro, S.L.; Dunwoodie, W.M.; Arens, J.F.; Jernigan, J.G.

    1989-05-01

    Two-dimensional arrays of solid state detectors have long been used in visible and infrared systems. Hybrid arrays with separately optimized detector and readout substrates have been extensively developed for infrared sensors. The characteristics and use of these infrared readout chips with silicon PIN diode arrays produced by MICRON SEMICONDUCTOR for detecting high-energy particles are reported. Some of these arrays have been produced in formats as large as 512 /times/ 512 pixels; others have been radiation hardened to total dose levels beyond 1 Mrad. Data generation rates of 380 megasamples/second have been achieved. Analog and digital signal transmission and processing techniques have also been developed to accept and reduce these high data rates. 9 refs., 15 figs., 2 tabs.

  7. Comparative cytogenetic characterization of primary canine melanocytic lesions using array CGH and fluorescence in situ hybridization.

    PubMed

    Poorman, Kelsey; Borst, Luke; Moroff, Scott; Roy, Siddharth; Labelle, Philippe; Motsinger-Reif, Alison; Breen, Matthew

    2015-06-01

    Melanocytic lesions originating from the oral mucosa or cutaneous epithelium are common in the general dog population, with up to 100,000 diagnoses each year in the USA. Oral melanoma is the most frequent canine neoplasm of the oral cavity, exhibiting a highly aggressive course. Cutaneous melanocytomas occur frequently, but rarely develop into a malignant form. Despite the differential prognosis, it has been assumed that subtypes of melanocytic lesions represent the same disease. To address the relative paucity of information about their genomic status, molecular cytogenetic analysis was performed on the three recognized subtypes of canine melanocytic lesions. Using array comparative genomic hybridization (aCGH) analysis, highly aberrant distinct copy number status across the tumor genome for both of the malignant melanoma subtypes was revealed. The most frequent aberrations included gain of dog chromosome (CFA) 13 and 17 and loss of CFA 22. Melanocytomas possessed fewer genome wide aberrations, yet showed a recurrent gain of CFA 20q15.3-17. A distinctive copy number profile, evident only in oral melanomas, displayed a sigmoidal pattern of copy number loss followed immediately by a gain, around CFA 30q14. Moreover, when assessed by fluorescence in situ hybridization (FISH), copy number aberrations of targeted genes, such as gain of c-MYC (80 % of cases) and loss of CDKN2A (68 % of cases), were observed. This study suggests that in concordance with what is known for human melanomas, canine melanomas of the oral mucosa and cutaneous epithelium are discrete and initiated by different molecular pathways. PMID:25511566

  8. Array Comparative Genomic Hybridization (aCGH) Analysis in Patients with Anophthalmia, Microphthalmia and Coloboma

    PubMed Central

    Raca, Gordana; Jackson, Craig A.; Kucinskas, Laimutis; Warman, Berta; Shieh, Joseph T. C.; Schneider, Adele; Bardakjian, Tanya M.; Schimmenti, Lisa A.

    2014-01-01

    Purpose The goal of our study was to determine whether genomic copy number abnormalities (deletions and duplications) affecting genes involved in eye development contribute to the etiology of anophthalmia, microphthalmia and coloboma. Methods The affected individuals were tested for deletions and duplications in genomic DNA using 2 million probe (HD2) comparative genomic hybridization arrays (aCGH) from Roche-NimbleGen. Results Array analysis of 32 patients detected one case with a deletion encompassing the Renal-coloboma syndrome associated gene PAX2. Non-polymorphic copy number changes were also observed at several candidate chromosomal regions, including 6p12.3, 8q23.1q23.2, 13q31.3, 15q11.2q13.1, 16p13.13 and 20q13.13. Conclusions This study identified the first patient with the typical phenotype of the Renal-coloboma syndrome caused by a submicroscopic deletion of the coding region of the PAX2 gene. The finding suggests that PAX2 deletion testing should be performed in addition to gene sequencing as a part of molecular evaluation for the Renal-coloboma syndrome. aCGH testing of 32 affected individual showed that genomic deletions and duplications are not a common cause of non-syndromic anophthalmia, microphthalmia and/or coloboma, but undoubtedly contribute to the etiology of these eye anomalies. aCGH testing therefore represents an important and valuable addition to candidate gene sequencing in research and diagnostics of ocular birth defects. PMID:21285886

  9. Plasmon-enhanced second-harmonic generation from hybrid ZnO-covered silver-bowl array

    NASA Astrophysics Data System (ADS)

    Yang, Mingming; Shen, Shaoxin; Wang, Xiangjie; Yu, Binbin; Huang, Shengli; Xu, Die; Hu, Jiawen; Yang, Zhilin

    2016-06-01

    High-efficient, plasmon-enhanced nonlinear phenomena based on hybrid nanostructures, which combine nonlinear dielectrics with plasmonic metals, are of fundamental importance for various applications ranging from all-optical switching to imaging or bio-sensing. However, the high loss of the excitation energy in nanostructures and the poor spatial overlap between the plasmon enhancement and the bulk of nonlinear materials largely limit the operation of plasmon-enhanced nonlinear effects, resulting in low nonlinear conversion efficiency. Here, we design and fabricate a ZnO-covered, 2D silver-bowl array, which can serve as an efficient platform for plasmon-enhanced second-harmonic generation (PESHG). Validated by experiments and simulations, we demonstrate that the high spatial overlap between the near-field enhancement and the ZnO film plays the key role for this nanostructure-based PESHG process. The enhancement mainly originates from the fundamental wavelength-derived plasmon resonance, providing an enhancement factor of approximately 33 times. These results achieved pave the way for future applications, which require localized light sources at nanoscale.

  10. Plasmon-enhanced second-harmonic generation from hybrid ZnO-covered silver-bowl array.

    PubMed

    Yang, Mingming; Shen, Shaoxin; Wang, Xiangjie; Yu, Binbin; Huang, Shengli; Xu, Die; Hu, Jiawen; Yang, Zhilin

    2016-06-01

    High-efficient, plasmon-enhanced nonlinear phenomena based on hybrid nanostructures, which combine nonlinear dielectrics with plasmonic metals, are of fundamental importance for various applications ranging from all-optical switching to imaging or bio-sensing. However, the high loss of the excitation energy in nanostructures and the poor spatial overlap between the plasmon enhancement and the bulk of nonlinear materials largely limit the operation of plasmon-enhanced nonlinear effects, resulting in low nonlinear conversion efficiency. Here, we design and fabricate a ZnO-covered, 2D silver-bowl array, which can serve as an efficient platform for plasmon-enhanced second-harmonic generation (PESHG). Validated by experiments and simulations, we demonstrate that the high spatial overlap between the near-field enhancement and the ZnO film plays the key role for this nanostructure-based PESHG process. The enhancement mainly originates from the fundamental wavelength-derived plasmon resonance, providing an enhancement factor of approximately 33 times. These results achieved pave the way for future applications, which require localized light sources at nanoscale. PMID:27145724

  11. A model of binding on DNA microarrays: understanding the combined effect of probe synthesis failure, cross-hybridization, DNA fragmentation and other experimental details of affymetrix arrays

    PubMed Central

    2012-01-01

    Background DNA microarrays are used both for research and for diagnostics. In research, Affymetrix arrays are commonly used for genome wide association studies, resequencing, and for gene expression analysis. These arrays provide large amounts of data. This data is analyzed using statistical methods that quite often discard a large portion of the information. Most of the information that is lost comes from probes that systematically fail across chips and from batch effects. The aim of this study was to develop a comprehensive model for hybridization that predicts probe intensities for Affymetrix arrays and that could provide a basis for improved microarray analysis and probe development. The first part of the model calculates probe binding affinities to all the possible targets in the hybridization solution using the Langmuir isotherm. In the second part of the model we integrate details that are specific to each experiment and contribute to the differences between hybridization in solution and on the microarray. These details include fragmentation, wash stringency, temperature, salt concentration, and scanner settings. Furthermore, the model fits probe synthesis efficiency and target concentration parameters directly to the data. All the parameters used in the model have a well-established physical origin. Results For the 302 chips that were analyzed the mean correlation between expected and observed probe intensities was 0.701 with a range of 0.88 to 0.55. All available chips were included in the analysis regardless of the data quality. Our results show that batch effects arise from differences in probe synthesis, scanner settings, wash strength, and target fragmentation. We also show that probe synthesis efficiencies for different nucleotides are not uniform. Conclusions To date this is the most complete model for binding on microarrays. This is the first model that includes both probe synthesis efficiency and hybridization kinetics/cross-hybridization. These

  12. Monolithically integrated 20-channel optical add/drop multiplexer subsystem with hybrid-integrated 40-channel photodetector array

    NASA Astrophysics Data System (ADS)

    Schumacher, Andreas B.; Krabe, Detlef; Dieckroeger, Jens; Spott, Thorsten; Kraeker, Tobias; Martins, Evely; Zavrsnik, Miha; Schneider, Hartmut W.; Baumann, Ingo

    2003-03-01

    We built a 20 channel, 200 GHz, fully reconfigurable optical add-/drop multiplexer with integrated variable optical attenuators and power monitor diodes. A single planar lightwave circuit chip contains demultiplexer, switch array, attenuators and multiplexers. It also serves as an "optical motherboard" for a hybrid, flip-chip assembly containing four 10-channel photo detector arrays. A thermal management concept which considers both microscopic and macroscopic aspects of the device was developed. The final device exhibits an insertion loss of 9 dB from "in"- to "through"-port, a 1 dB bandwidth of >50 GHz and switch extinction ratios in excess of 40 dB.

  13. Formulation Development and Evaluation of Hybrid Nanocarrier for Cancer Therapy: Taguchi Orthogonal Array Based Design

    PubMed Central

    Tekade, Rakesh K.; Chougule, Mahavir B.

    2013-01-01

    Taguchi orthogonal array design is a statistical approach that helps to overcome limitations associated with time consuming full factorial experimental design. In this study, the Taguchi orthogonal array design was applied to establish the optimum conditions for bovine serum albumin (BSA) nanocarrier (ANC) preparation. Taguchi method with L9 type of robust orthogonal array design was adopted to optimize the experimental conditions. Three key dependent factors namely, BSA concentration (% w/v), volume of BSA solution to total ethanol ratio (v : v), and concentration of diluted ethanolic aqueous solution (% v/v), were studied at three levels 3%, 4%, and 5% w/v; 1 : 0.75, 1 : 0.90, and 1 : 1.05 v/v; 40%, 70%, and 100% v/v, respectively. The ethanolic aqueous solution was used to impart less harsh condition for desolvation and attain controlled nanoparticle formation. The interaction plot studies inferred the ethanolic aqueous solution concentration to be the most influential parameter that affects the particle size of nanoformulation. This method (BSA, 4% w/v; volume of BSA solution to total ethanol ratio, 1 : 0.90 v/v; concentration of diluted ethanolic solution, 70% v/v) was able to successfully develop Gemcitabine (G) loaded modified albumin nanocarrier (M-ANC-G) of size 25.07 ± 2.81 nm (ζ = −23.03 ± 1.015 mV) as against to 78.01 ± 4.99 nm (ζ = −24.88 ± 1.37 mV) using conventional method albumin nanocarrier (C-ANC-G). Hybrid nanocarriers were generated by chitosan layering (solvent gelation technique) of respective ANC to form C-HNC-G and M-HNC-G of sizes 125.29 ± 5.62 nm (ζ = 12.01 ± 0.51 mV) and 46.28 ± 2.21 nm (ζ = 15.05 ± 0.39 mV), respectively. Zeta potential, entrapment, in vitro release, and pH-based stability studies were investigated and influence of formulation parameters are discussed. Cell-line-based cytotoxicity assay (A549 and H460 cells) and cell internalization assay (H460 cell line) were

  14. Focal plane array based infrared thermography in fine physical experiment

    NASA Astrophysics Data System (ADS)

    Vainer, Boris G.

    2008-03-01

    By two examples of dissimilar physical phenomena causing thermophysical effects, the unique capabilities of one of the up-to-date methods of experimental physics—focal plane array (FPA) based infrared (IR) thermography (IRT), are demonstrated distinctly. Experimenters inexperienced in IRT can grasp how this method provides a means for combining real-time visualization with quantitative analysis. A narrow-band short-wavelength IR camera was used in the experiments. It is discussed and stated that IRT is best matched and suited to the next two test conditions—when a heated specimen is thin and when heat is generated in the immediate region of a surface of a solid. The first prerequisite is realized in the search for directional patterns of combined low-power radiation sources with the use of the IRT-aided method. The second one is realized in studies of water vapour adsorption on uneven (irregular) surfaces of solid materials. With multiple swatches taken from a set of different fabrics and used as experimental samples, a sharp distinction between adsorptivities of their surfaces is strikingly illustrated by IRT time-domain measurements exhibiting the associated thermal effect ranging within an order of magnitude. It is justified that the described IRT-aided test can find practical implementation at least in the light industry. Emissivities of different fabrics are evaluated experimentally with the described reflection method based on the narrow spectral range of IRT. On the basis of direct IR observations, attention is paid to the need for close control over the surface temperature increase while the adsorption isotherms are being measured. Sensitivity of the FPA-based IRT method, as applied to examine the kinetics of initial stages of adsorption of gaseous molecules on the solid surface, is evaluated analytically and quantitatively. The relationship between the amount of adsorbate and the measurable excess of adsorbent temperature is found. It is discovered

  15. Homozygous losses detected by array comparative genomic hybridization in multiplex urothelial carcinomas of the bladder.

    PubMed

    Beothe, Tamas; Zubakov, Dmitry; Kovacs, Gyula

    2015-09-01

    Urothelial carcinomas (UCs) may present at first as a solitary or multifocal neoplasm. We applied high resolution array comparative genomic hybridization to 24 solitary and 32 multiplex UCs and used the hidden Markov model algorithm to identify the copy number changes at the probe level. Copy number losses and homozygous deletions at the chromosome 9p region affecting the CDKN2A and MTAP genes were the most frequent alterations in both groups of tumors. We have delineated two new tumor suppressor gene regions at chromosome 9p that harbor the PTPRD and BNC2 genes. Copy number losses at chromosomal regions 2q, 8p, and 18p occurred preferentially in solitary UCs, whereas multiplex UCs displayed loss of large chromosomal regions at 9q, 10q, 11q, 18q, and 21q. Homozygous deletions harboring loci of cell adhesion genes such as claudins, desmocollins, and desmogleins were seen exclusively in multiplex UCs. Amplifications occurred only in invasive G3 UCs irrespective of staging. Our study suggests that solitary and multiplex UCs may have divergent genetic pathways. The biallelic inactivation of cellular adhesion genes by homozygous deletions in multiplex UCs may explain the frequent intravesical spreading of tumor cells. . PMID:26235493

  16. Genomic copy number alterations in 33 malignant peritoneal mesothelioma analyzed by comparative genomic hybridization array.

    PubMed

    Chirac, Pierre; Maillet, Denis; Leprêtre, Frédéric; Isaac, Sylvie; Glehen, Olivier; Figeac, Martin; Villeneuve, Laurent; Péron, Julien; Gibson, Fernando; Galateau-Sallé, Françoise; Gilly, François-Noël; Brevet, Marie

    2016-09-01

    Malignant peritoneal mesotheliomas (MPM) are rare, accounting for approximately 8% of cases of mesothelioma in France. We performed comparative genomic hybridization (CGH) on frozen MPM samples using the Agilent Human Genome CGH 180 K array. Samples were taken from a total of 33 French patients, comprising 20 men and 13 women with a mean (range) age of 58.4 (17-76) years. Asbestos exposure was reported in 8 patients (24.2%). Median (range) overall survival (OS) was 39 (0-119) months. CGH analysis demonstrated the presence of chromosomal instability in patients with MPM, with a genomic pattern that was similar to that described for pleural mesothelioma, including the loss of chromosomal regions 3p21, 9p21, and 22q12. In addition, novel genomic copy number alterations were identified, including the 15q26.2 region and the 8p11.22 region. Median OS was associated with a low peritoneal cancer index (P=.011), epithelioid subtype (P=.038), and a low number of genomic aberrations (P=.015), all of which constitute good prognostic factors for MPM. Our results provide new insights into the genetic and genomic background of MPM. Although pleural and peritoneal mesotheliomas have different risk factors, different therapeutics, and different prognosis; these data provide support to combine pleural and peritoneal mesothelioma in same clinical assays. PMID:27184482

  17. SiGe Integrated Circuit/SQUID Hybrid Cryogenic Multiplexer for Superconducting Bolometer Array

    NASA Astrophysics Data System (ADS)

    Prêle, D.; Voisin, F.; Oger, R.; Chapron, C.; Bréelle, E.; Piat, M.

    2009-12-01

    The development of large superconducting bolometer (Transition Edge Sensor: TES) arrays requires ultra low noise amplification and multiplexing electronics. The use of a first transducer stage such as a SQUID (Superconducting QUantum Interference Device) allows ultimate performance in terms of noise. However, the linearization of the SQUID characteristic requires low noise amplification. Furthermore, to realize a time domain multiplexer with SQUIDs, switched biasing is also needed. We have designed an Integrated Circuit (IC) in standard BiCMOS SiGe technology for the readout and the control of a SQUID multiplexer. It includes a low noise amplifier with multiplexed inputs, switched current sources for SQUIDs, and digital circuit for the addressing with only one room temperature clock signal. We have successfully tested this integrated circuit down to 2 K. To validate the operation of a SQUID multiplexer controlled by this SiGe cryogenic IC, we have developed a 2×2 SQUID hybrid demonstrator. It consists of four commercial SQUIDs connected to a SiGe IC.

  18. Photoconductive terahertz near-field detector with a hybrid nanoantenna array cavity

    SciTech Connect

    Mitrofanov, Oleg; Brener, Igal; Luk, Ting S.; Reno, John L.

    2015-11-19

    Nanoscale structuring of optical materials leads to modification of their properties and can be used for improving efficiencies of photonic devices and for enabling new functionalities. In ultrafast optoelectronic switches for generation and detection of terahertz (THz) radiation, incorporation of nanostructures allows us to overcome inherent limitations of photoconductive materials. We propose and demonstrate a nanostructured photoconductive THz detector for sampling highly localized THz fields, down to the level of λ/150. The nanostructure that consists of an array of optical nanoantennas and a distributed Bragg reflector forms a hybrid cavity, which traps optical gate pulses within the photoconductive layer. The effect of photon trapping is observed as enhanced absorption at a designed wavelength. This optically thin photoconductive THz detector allows us to detect highly confined evanescent THz fields coupled through a deeply subwavelength aperture as small as 2 μm (λ/150 at 1 THz). As a result, by monolithically integrating the THz detector with apertures ranging from 2 to 5 μm we realize higher spatial resolution and higher sensitivity in aperture-type THz near-field microscopy and THz time-domain spectroscopy.

  19. Photoconductive terahertz near-field detector with a hybrid nanoantenna array cavity

    DOE PAGESBeta

    Mitrofanov, Oleg; Brener, Igal; Luk, Ting S.; Reno, John L.

    2015-11-19

    Nanoscale structuring of optical materials leads to modification of their properties and can be used for improving efficiencies of photonic devices and for enabling new functionalities. In ultrafast optoelectronic switches for generation and detection of terahertz (THz) radiation, incorporation of nanostructures allows us to overcome inherent limitations of photoconductive materials. We propose and demonstrate a nanostructured photoconductive THz detector for sampling highly localized THz fields, down to the level of λ/150. The nanostructure that consists of an array of optical nanoantennas and a distributed Bragg reflector forms a hybrid cavity, which traps optical gate pulses within the photoconductive layer. Themore » effect of photon trapping is observed as enhanced absorption at a designed wavelength. This optically thin photoconductive THz detector allows us to detect highly confined evanescent THz fields coupled through a deeply subwavelength aperture as small as 2 μm (λ/150 at 1 THz). As a result, by monolithically integrating the THz detector with apertures ranging from 2 to 5 μm we realize higher spatial resolution and higher sensitivity in aperture-type THz near-field microscopy and THz time-domain spectroscopy.« less

  20. A slot-scanned photodiode-array/CCD hybrid detector for digital mammography.

    PubMed

    Mainprize, James G; Ford, Nancy L; Yin, Shi; Tümer, Türmay; Yaffe, Martin J

    2002-02-01

    We have developed a novel direct conversion detector for use in a slot-scanning digital mammography system. The slot-scan concept allows for dose efficient scatter rejection and the ability to use small detectors to produce a large-area image. The detector is a hybrid design with a 1.0 mm thick silicon PIN photodiode array (the x-ray absorber) indium-bump bonded to a CCD readout that is operated in time-delay integration (TDI) mode. Because the charge capacity requirement for good image quality exceeds the capabilities of standard CCDs, a novel CCD was developed. This CCD consists of 24 independent sections, each acting as a miniature CCD with eight rows for TDI. The signal from each section is combined off-chip to produce a full signal image. The MTF and DQE for the device was measured at several exposures and compared to a linear systems model of signal and noise propagation. Because of the scanning nature of TDI imaging, both the MTF(f) and DQE(f) are reduced along the direction of the scanning motion. For a 26 kVp spectrum, the DQE(0) was measured to be 0.75+/-0.02 for an exposure of 1.29 x 10(-5) C/kg (50 mR). PMID:11865992

  1. Mechanical Design and Development of TES Bolometer Detector Arrays for the Advanced ACTPol Experiment

    NASA Technical Reports Server (NTRS)

    Ward, Jonathan T.; Austermann, Jason; Beall, James A.; Choi, Steve K.; Crowley, Kevin T.; Devlin, Mark J.; Duff, Shannon M.; Gallardo, Patricio M.; Henderson, Shawn W.; Ho, Shuay-Pwu Patty; Hilton, Gene; Hubmayr, Johannes; Khavari, Niloufar; Klein, Jeffrey; Koopman, Brian J.; Li, Dale; McMahon, Jeffrey; Mumby, Grace; Nati, Federico; Wollack, Edward J.

    2016-01-01

    The next generation Advanced ACTPol (AdvACT) experiment is currently underway and will consist of four Transition Edge Sensor (TES) bolometer arrays, with three operating together, totaling 5800 detectors on the sky. Building on experience gained with the ACTPol detector arrays, AdvACT will utilize various new technologies, including 150 mm detector wafers equipped with multichroic pixels, allowing for a more densely packed focal plane. Each set of detectors includes a feedhorn array of stacked silicon wafers which form a spline pro le leading to each pixel. This is then followed by a waveguide interface plate, detector wafer, back short cavity plate, and backshort cap. Each array is housed in a custom designed structure manufactured from high purity copper and then gold plated. In addition to the detector array assembly, the array package also encloses cryogenic readout electronics. We present the full mechanical design of the AdvACT high frequency (HF) detector array package along with a detailed look at the detector array stack assemblies. This experiment will also make use of extensive hardware and software previously developed for ACT, which will be modi ed to incorporate the new AdvACT instruments. Therefore, we discuss the integration of all AdvACT arrays with pre-existing ACTPol infrastructure.

  2. Validation Report for the EO-1 Lightweight Flexible Solar Array Experiment

    NASA Technical Reports Server (NTRS)

    Carpenter, Bernie; Lyons, John; Day, John (Technical Monitor)

    2001-01-01

    The controlled deployment of the Lightweight Flexible Solar Array (LFSA) experiment using the shape memory alloy release and deployment system has been demonstrated. Work remains to be done in increasing the efficiency of Copper Indium Diselinide (CIS) terminations to the flexible harness that carries current from the array to the I-V measurement electronics.

  3. Highly Ordered Vertical Arrays of TiO2/ZnO Hybrid Nanowires: Synthesis and Electrochemical Characterization.

    PubMed

    Gujarati, Tanvi P; Ashish, Ajithan G; Rai, Maniratnam; Shaijumon, Manikoth M

    2015-08-01

    We report the fabrication of vertically aligned hierarchical arrays of TiO2/ZnO hybrid nanowires, consisting of ZnO nanowires grown directly from within the pores of TiO2 nanotubes, through a combination of electrochemical anodization and hydrothermal techniques. These novel nano-architectured hybrid nanowires with its unique properties show promise as high performance supercapacitor electrodes. The electrochemical behaviour of these hybrid nanowires has been studied using Cyclic voltammetry, Galvanostatic charge-discharge and Electrochemical impedance spectroscopy (EIS) measurements using 1.5 M tetraethylammoniumtetrafluoroborate in acetonitrile as the electrolyte. Excellent electrochemical performances with a maximum specific capacitance of 2.6 mF cm-2 at a current density of 10 µA cm-2, along with exceptional cyclic stability, have been obtained for TiO2/ZnO-1 h hybrid material. The obtained results demonstrate the possibility of fabricating new geometrical architectures of inorganic hybrid nanowires with well adhered interfaces for the development of hybrid energy devices. PMID:26369158

  4. Carbon fiber/Co9S8 nanotube arrays hybrid structures for flexible quantum dot-sensitized solar cells.

    PubMed

    Guo, Wenxi; Chen, Chang; Ye, Meidan; Lv, Miaoqiang; Lin, Changjian

    2014-04-01

    Recently, hybrid carbon materials and inorganic nanocrystals have received an intensive amount of attention and have opened up an exciting new field in the design and fabrication of high-performance catalysts. Here we present a novel kind of hybrid counter electrode (CE) consisting of a carbon fiber (CF) and Co9S8 nanotube arrays (NTs) for fiber-shaped flexible quantum dot-sensitized solar cells (QDSSCs). The growth mechanisms of Co(CO3)0.35Cl0.20(OH)1.10 nanowire arrays (NWs) on the CFs were discussed, and the catalytic activity of the CF, Pt and Co9S8/CF hybrid structure (Co9S8@CF) were elucidated systematically as well. An absolute energy conversion efficiency of 3.79% has been demonstrated under 100 mW cm(-2) AM 1.5 illumination by using Co9S8@CF as a CE. This work not only demonstrates an innovative approach for growing cobalt sulfide NTs on flexible substrates that can be applied in flexible devices for energy harvesting and storage, but also provides a kind of hybrid structure and high-efficiency CE for QDSSCs. PMID:24562374

  5. An Improved Solution for Integrated Array Optics in Quasi-Optical mm and Submm Receivers: the Hybrid Antenna

    NASA Technical Reports Server (NTRS)

    Buttgenbach, Thomas H.

    1993-01-01

    The hybrid antenna discussed here is defined as a dielectric lens-antenna as a special case of an extended hemi-spherical dielectric lens that is operated in the diffraction limited regime. It is a modified version of the planar antenna on a lens scheme developed by Rutledge. The dielectric lens-antenna is fed by a planar-structure antenna, which is mounted on the flat side of the dielectric lens-antenna using it as a substrate, and the combination is termed a hybrid antenna. Beam pattern and aperture efficiency measurements were made at millimeter and submillimeter wavelengths as a function of extension of the hemi- spherical lens and different lens sizes. An optimum extension distance is found experimentally and numerically for which excellent beam patterns and simultaneously high aperture efficiencies can be achieved. At 115 GHz the aperture efficiency was measured to be (76 4 +/- 6) % for a diffraction limited beam with sidelobes below -17 dB. Results of a single hybrid antenna with an integrated Superconductor-Insulator-Superconductor (SIS) detector and a broad-band matching structure at submillimeter wavelengths are presented. The hybrid antenna is diffraction limited, space efficient in an array due to its high aperture efficiency, and is easily mass produced, thus being well suited for focal plane heterodyne receiver arrays.

  6. An improved solution for integrated array optics in quasi-optical mm and submm receivers: The hybrid antenna

    SciTech Connect

    Buettgenback, T.H. . Div. of Physics)

    1993-10-01

    The hybrid antenna discussed here is defined as a dielectric lens-antenna as a special case of an extended hemispherical dielectric lens that is operated in the diffraction limited regime. It is a modified version of the planar antenna on a lens scheme developed by Rutledge. The dielectric lens-antenna is fed by a planar-structure antenna, which is mounted on the flat side of the dielectric lens-antenna using it as a substrate, and the combination is termed a hybrid antenna. Beam pattern and aperture efficiency measurements were made at millimeter and submillimeter wavelengths as a function of extension of the hemispherical lens and different lens sizes. An optimum extension distance is found experimentally and numerically for which excellent beam patterns and simultaneously high aperture efficiencies can be achieved. At 115 GHz the aperture efficiency was measured to be (76 [+-] 6)% for a diffraction limited beam with sidelobes below [minus]17 dB. Results of a single hybrid antenna with an integrated Superconductor-Insulator-Superconductor (SIS) detector and a broad-band matching structure at submillimeter wavelengths are presented. The hybrid antenna is diffraction limited, space efficient in an array due to its high aperture efficiency, and is easily mass produced, thus being well suited for focal plane heterodyne receiver arrays.

  7. Experience with the UKIRT InSb array camera

    NASA Technical Reports Server (NTRS)

    Mclean, Ian S.; Casali, Mark M.; Wright, Gillian S.; Aspin, Colin

    1989-01-01

    The cryogenic infrared camera, IRCAM, has been operating routinely on the 3.8 m UK Infrared Telescope on Mauna Kea, Hawaii for over two years. The camera, which uses a 62x58 element Indium Antimonide array from Santa Barbara Research Center, was designed and built at the Royal Observatory, Edinburgh which operates UKIRT on behalf of the UK Science and Engineering Research Council. Over the past two years at least 60% of the available time on UKIRT has been allocated for IRCAM observations. Described here are some of the properties of this instrument and its detector which influence astronomical performance. Observational techniques and the power of IR arrays with some recent astronomical results are discussed.

  8. Array Comparative Genomic Hybridization in Ulcerative Colitis Neoplasia: Single Non-Dysplastic Biopsies Distinguish Progressors from Non-Progressors

    PubMed Central

    Bronner, Mary P.; Skacel, Marek; Crispin, David A.; Hoff, Peter D.; Emond, Mary J.; Lai, Lisa A.; Tubbs, Raymond R.; Rabinovitch, Peter S.; Brentnall, Teresa A.

    2010-01-01

    Approximately 10% of ulcerative colitis patients develop colorectal neoplasia. At present, identification of this subset is markedly limited and necessitates lifelong colonoscopic surveillance for the entire ulcerative colitis population. Better risk markers are needed to focus surveillance onto the patients most likely to benefit. Using array-based comparative genomic hybridization, we analyzed single, non-dysplastic biopsies from three patient groups: ulcerative colitis progressors (n=9) with cancer or high-grade dysplasia at a mean distance of 18 cm from the analyzed site; ulcerative colitis nonprogressors (n=8) without dysplasia during long-term surveillance; and non-ulcerative colitis normal controls (n=2). Genomic DNA from fresh colonic epithelium purified from stroma was hybridized to 287 (low-density) and 4,342 (higher-density) feature bacterial artificial chromosome arrays. Sample-to-reference fluorescence ratios were calculated for individual chromosomal targets and globally across the genome. The low-density arrays yielded pronounced genomic gains and losses in 3 of 9 (33%) ulcerative colitis progressors but in none of the 10 control patients. Identical DNA samples analyzed on the higher density arrays, using a combination of global and individual high variance assessments, distinguished all 9 progressors from all 10 controls. These data confirm that genomic alterations in ulcerative colitis progressors are widespread, even involving single non-dysplastic biopsies far distant from neoplasia. They therefore show promise toward eliminating full colonoscopic surveillance with extensive biopsy sampling in the majority of ulcerative colitis patients. PMID:20802465

  9. Fast and enhanced broadband photoresponse of a ZnO nanowire array/reduced graphene oxide film hybrid photodetector from the visible to the near-infrared range.

    PubMed

    Liu, Hao; Sun, Qi; Xing, Jie; Zheng, Zhiyuan; Zhang, Zhili; Lü, Zhiqing; Zhao, Kun

    2015-04-01

    In the present work, a ZnO nanowire array/reduced graphene oxide film hybrid nanostructure was realized, and the photovoltaic responses from the visible to the near-infrared range were investigated. Compared with the pure ZnO nanowire array and rGO thin film, the hybrid composite exhibited a fast and greatly enhanced broadband photovoltaic response that resulted from the formation of interfacial Schottky junctions between ZnO and rGO. PMID:25768384

  10. Arcing rates for High Voltage Solar Arrays - Theory, experiment, and predictions

    NASA Technical Reports Server (NTRS)

    Hastings, Daniel E.; Cho, Mengu; Kuninaka, Hitoshi

    1992-01-01

    All solar arrays have biased surfaces that can be exposed to the space environment. It has been observed that when the array bias is less than a few hundred volts negative, then the exposed conductive surfaces may undergo arcing in the space plasma. A theory for arcing is developed on these high voltage solar arrays that ascribes the arcing to electric field runaway at the interface of the plasma, conductor, and solar cell dielectric. Experiments were conducted in the laboratory for the High Voltage Solar Array experiment that will fly on the Japanese Space Flyer Unit (SFU) in 1994. The theory was compared in detail with the experiment and shown to give a reasonable explanation for the data. The combined theory and ground experiments were then used to develop predictions for the SFU flight.

  11. The arcing rate for a High Voltage Solar Array - Theory, experiment and predictions

    NASA Technical Reports Server (NTRS)

    Hastings, Daniel E.; Cho, Mengu; Kuninaka, Hitoshi

    1992-01-01

    All solar arrays have biased surfaces which can be exposed to the space environment. It has been observed that when the array bias is less than a few hundred volts negative then the exposed conductive surfaces may undergo arcing in the space plasma. A theory for arcing is developed on these high voltage solar arrays which ascribes the arcing to electric field runaway at the interface of the plasma, conductor and solar cell dielectric. Experiments were conducted in the laboratory for the High Voltage Solar Array (HVSA) experiment which will fly on the Japanese Space Flyer Unit (SFU) in 1994. The theory was compared in detail to the experiment and shown to give a reasonable explanation for the data. The combined theory and ground experiments were then used to develop predictions for the SFU flight.

  12. Identification of Genomic Alterations in Pancreatic Cancer Using Array-Based Comparative Genomic Hybridization

    PubMed Central

    Liang, Jian-Wei; Shi, Zhi-Zhou; Shen, Tian-Yun; Che, Xu; Wang, Zheng; Shi, Su-Sheng; Xu, Xin; Cai, Yan; Zhao, Ping; Wang, Cheng-Feng; Zhou, Zhi-Xiang; Wang, Ming-Rong

    2014-01-01

    Background Genomic aberration is a common feature of human cancers and also is one of the basic mechanisms that lead to overexpression of oncogenes and underexpression of tumor suppressor genes. Our study aims to identify frequent genomic changes in pancreatic cancer. Materials and Methods We used array comparative genomic hybridization (array CGH) to identify recurrent genomic alterations and validated the protein expression of selected genes by immunohistochemistry. Results Sixteen gains and thirty-two losses occurred in more than 30% and 60% of the tumors, respectively. High-level amplifications at 7q21.3–q22.1 and 19q13.2 and homozygous deletions at 1p33–p32.3, 1p22.1, 1q22, 3q27.2, 6p22.3, 6p21.31, 12q13.2, 17p13.2, 17q21.31 and 22q13.1 were identified. Especially, amplification of AKT2 was detected in two carcinomas and homozygous deletion of CDKN2C in other two cases. In 15 independent validation samples, we found that AKT2 (19q13.2) and MCM7 (7q22.1) were amplified in 6 and 9 cases, and CAMTA2 (17p13.2) and PFN1 (17p13.2) were homozygously deleted in 3 and 1 cases. AKT2 and MCM7 were overexpressed, and CAMTA2 and PFN1 were underexpressed in pancreatic cancer tissues than in morphologically normal operative margin tissues. Both GISTIC and Genomic Workbench software identified 22q13.1 containing APOBEC3A and APOBEC3B as the only homozygous deletion region. And the expression levels of APOBEC3A and APOBEC3B were significantly lower in tumor tissues than in morphologically normal operative margin tissues. Further validation showed that overexpression of PSCA was significantly associated with lymph node metastasis, and overexpression of HMGA2 was significantly associated with invasive depth of pancreatic cancer. Conclusion These recurrent genomic changes may be useful for revealing the mechanism of pancreatic carcinogenesis and providing candidate biomarkers. PMID:25502777

  13. Genomic Characterization of Prenatally Detected Chromosomal Structural Abnormalities Using Oligonucleotide Array Comparative Genomic Hybridization

    PubMed Central

    Li, Peining; Pomianowski, Pawel; DiMaio, Miriam S.; Florio, Joanne R.; Rossi, Michael R.; Xiang, Bixia; Xu, Fang; Yang, Hui; Geng, Qian; Xie, Jiansheng; Mahoney, Maurice J.

    2013-01-01

    Detection of chromosomal structural abnormalities using conventional cytogenetic methods poses a challenge for prenatal genetic counseling due to unpredictable clinical outcomes and risk of recurrence. Of the 1,726 prenatal cases in a 3-year period, we performed oligonucleotide array comparative genomic hybridization (aCGH) analysis on 11 cases detected with various structural chromosomal abnormalities. In nine cases, genomic aberrations and gene contents involving a 3p distal deletion, a marker chromosome from chromosome 4, a derivative chromosome 5 from a 5p/7q translocation, a de novo distal 6q deletion, a recombinant chromosome 8 comprised of an 8p duplication and an 8q deletion, an extra derivative chromosome 9 from an 8p/9q translocation, mosaicism for chromosome 12q with added material of initially unknown origin, an unbalanced 13q/15q rearrangement, and a distal 18q duplication and deletion were delineated. An absence of pathogenic copy number changes was noted in one case with a de novo 11q/14q translocation and in another with a familial insertion of 21q into a 19q. Genomic characterization of the structural abnormalities aided in the prediction of clinical outcomes. These results demonstrated the value of aCGH analysis in prenatal cases with subtle or complex chromosomal rearrangements. Furthermore, a retrospective analysis of clinical indications of our prenatal cases showed that approximately 20% of them had abnormal ultrasound findings and should be considered as high risk pregnancies for a combined chromosome and aCGH analysis. PMID:21671377

  14. Development of Yangbajing air shower core detector for a new EAS hybrid experiment

    NASA Astrophysics Data System (ADS)

    Liu, Jin-Sheng; Huang, Jing; Chen, Ding; Zhang, Ying; Zhai, Liu-Ming; Chen, Xu; Hu, Xiao-Bin; Lin, Yu-Hui; Zhang, Xue-Yao; Feng, Cun-Feng; Jia, Huan-Yu; Zhou, Xun-Xiu; Danzengluobu; Chen, Tian-Lu; Li, Hai-Jin; Liu, Mao-Yuan; Yuan, Ai-Fang

    2015-08-01

    Aiming at the observation of cosmic-ray chemical composition in the “knee” energy region, we have been developing a new type of air-shower core detector (YAC, Yangbajing Air shower Core detector array) to be set up at Yangbajing (90.522° E, 30.102° N, 4300 m above sea level, atmospheric depth: 606 g/m2) in Tibet, China. YAC works together with the Tibet air-shower array (Tibet-III) and an underground water Cherenkov muon detector array (MD) as a hybrid experiment. Each YAC detector unit consists of lead plates of 3.5 cm thickness and a scintillation counter which detects the burst size induced by high energy particles in the air-shower cores. The burst size can be measured from 1 MIP (Minimum Ionization Particle) to 106 MIPs. The first phase of this experiment, named “YAC- I”, consists of 16 YAC detectors each with a size of 40 cm×50 cm and distributed in a grid with an effective area of 10 m2. YAC- I is used to check hadronic interaction models. The second phase of the experiment, called “YAC- II”, consists of 124 YAC detectors with coverage of about 500 m2. The inner 100 detectors of 80 cm×50 cm each are deployed in a 10×10 matrix with a 1.9 m separation; the outer 24 detectors of 100 cm×50 cm each are distributed around these to reject non-core events whose shower cores are far from the YAC- II array. YAC- II is used to study the primary cosmic-ray composition, in particular, to obtain the energy spectra of protons, helium and iron nuclei between 5×1013 eV and 1016 eV, covering the “knee” and also connected with direct observations at energies around 100 TeV. We present the design and performance of YAC- II in this paper. Supported by grants from the National Natural Science Foundation of China (11078002, 11275212, 11165013), the Chinese Academy of Sciences (H9291450S3, Y4293211S5) and the Knowledge Innovation Fund of Institute of High Energy Physics (IHEP), China (H95451D0U2, H8515530U1)

  15. Study of Ultra-High Energy Cosmic Ray composition using Telescope Array's Middle Drum detector and surface array in hybrid mode

    NASA Astrophysics Data System (ADS)

    Abbasi, R. U.; Abe, M.; Abu-Zayyad, T.; Allen, M.; Anderson, R.; Azuma, R.; Barcikowski, E.; Belz, J. W.; Bergman, D. R.; Blake, S. A.; Cady, R.; Chae, M. J.; Cheon, B. G.; Chiba, J.; Chikawa, M.; Cho, W. R.; Fujii, T.; Fukushima, M.; Goto, T.; Hanlon, W.; Hayashi, Y.; Hayashida, N.; Hibino, K.; Honda, K.; Ikeda, D.; Inoue, N.; Ishii, T.; Ishimori, R.; Ito, H.; Ivanov, D.; Jui, C. C. H.; Kadota, K.; Kakimoto, F.; Kalashev, O.; Kasahara, K.; Kawai, H.; Kawakami, S.; Kawana, S.; Kawata, K.; Kido, E.; Kim, H. B.; Kim, J. H.; Kim, J. H.; Kitamura, S.; Kitamura, Y.; Kuzmin, V.; Kwon, Y. J.; Lan, J.; Lim, S. I.; Lundquist, J. P.; Machida, K.; Martens, K.; Matsuda, T.; Matsuyama, T.; Matthews, J. N.; Minamino, M.; Mukai, Y.; Myers, I.; Nagasawa, K.; Nagataki, S.; Nakamura, T.; Nonaka, T.; Nozato, A.; Ogio, S.; Ogura, J.; Ohnishi, M.; Ohoka, H.; Oki, K.; Okuda, T.; Ono, M.; Oshima, A.; Ozawa, S.; Park, I. H.; Pshirkov, M. S.; Rodriguez, D. C.; Rubtsov, G.; Ryu, D.; Sagawa, H.; Sakurai, N.; Sampson, A. L.; Scott, L. M.; Shah, P. D.; Shibata, F.; Shibata, T.; Shimodaira, H.; Shin, B. K.; Shin, H. S.; Smith, J. D.; Sokolsky, P.; Springer, R. W.; Stokes, B. T.; Stratton, S. R.; Stroman, T.; Suzawa, T.; Takamura, M.; Takeda, M.; Takeishi, R.; Taketa, A.; Takita, M.; Tameda, Y.; Tanaka, H.; Tanaka, K.; Tanaka, M.; Thomas, S. B.; Thomson, G. B.; Tinyakov, P.; Tkachev, I.; Tokuno, H.; Tomida, T.; Troitsky, S.; Tsunesada, Y.; Tsutsumi, K.; Uchihori, Y.; Udo, S.; Urban, F.; Vasiloff, G.; Wong, T.; Yamane, R.; Yamaoka, H.; Yamazaki, K.; Yang, J.; Yashiro, K.; Yoneda, Y.; Yoshida, S.; Yoshii, H.; Zollinger, R.; Zundel, Z.

    2015-04-01

    Previous measurements of the composition of Ultra-High Energy Cosmic Rays (UHECRs) made by the High Resolution Fly's Eye (HiRes) and Pierre Auger Observatory (PAO) are seemingly contradictory, but utilize different detection methods, as HiRes was a stereo detector and PAO is a hybrid detector. The five year Telescope Array (TA) Middle Drum hybrid composition measurement is similar in some, but not all, respects in methodology to PAO, and good agreement is evident between data and a light, largely protonic, composition when comparing the measurements to predictions obtained with the QGSJetII-03 and QGSJet-01c models. These models are also in agreement with previous HiRes stereo measurements, confirming the equivalence of the stereo and hybrid methods. The data is incompatible with a pure iron composition, for all models examined, over the available range of energies. The elongation rate and mean values of Xmax are in good agreement with Pierre Auger Observatory data. This analysis is presented using two methods: data cuts using simple geometrical variables and a new pattern recognition technique.

  16. Lower-hybrid-heating experiments on the Alcator C and the Versator II Tokamaks

    NASA Astrophysics Data System (ADS)

    Porkolab, M.; Schuss, J. J.; Takase, Y.; Texter, S.; Fiore, C. L.; Gandy, R.; Greenwald, M. J.; Gwinn, D. A.; Lipschultz, B.; Marmar, E. S.

    Initial results from lower hybrid wave heating experiments carried out on the MIT Alcator-C and Versator II Tokamak are reported. In the Alcator-C experiments a 4 waveguide array, with internally brazed ceramic windows was used to inject 160 kW of microwave power at 4.6 GHz into the plasma with nO less than or equal to 1 x 10(15) cm(+3), and BO less than or equal to 12 T. The RF coupling studies show optimal coupling when the local density at the waveguide mouth is 25 to 50 times overdense. Heating experiments show an ion tail formation in hydrogen discharge peaking at a density of anti-n approx. = 2.7 x 10(14) cm(+3) at B = 8.9 T, and bulk ion heating at a density of anti n approx. = 1.5 x 10(14) c(+3) at B approx. = 11 T. Evidence of RF current enhancement has been observed at a density of n approx. = 3 x 10(13) cm (+3). Doppler broadening of the OVII and NVI lines shows a (RADICAL)T/sub i/= 50 eV rise in the bulk ion temperature. A significant RF produced ion tail is also observed by charge exchange analysis. A toroidal ray tracing code and a 1-D transport code to study the heating density bands and heating efficiencies were successfully combined.

  17. Clinical Utility of Array Comparative Genomic Hybridization for Detection of Chromosomal Abnormalities in Pediatric Acute Lymphoblastic Leukemia

    PubMed Central

    Rabin, Karen R.; Man, Tsz-Kwong; Yu, Alexander; Folsom, Matthew R.; Zhao, Yi-Jue; Rao, Pulivarthi H.; Plon, Sharon E.; Naeem, Rizwan C.

    2014-01-01

    Background Accurate detection of recurrent chromosomal abnormalities is critical to assign patients to risk-based therapeutic regimens for pediatric acute lymphoblastic leukemia (ALL). Procedure We investigated the utility of array comparative genomic hybridization (aCGH) for detection of chromosomal abnormalities compared to standard clinical evaluation with karyotype and fluorescent in-situ hybridization (FISH). Fifty pediatric ALL diagnostic bone marrows were analyzed by bacterial artificial chromosome (BAC) array, and findings compared to standard clinical evaluation. Results Sensitivity of aCGH was 79% to detect karyotypic findings other than balanced translocations, which cannot be detected by aCGH because they involve no copy number change. aCGH also missed abnormalities occurring in subclones constituting less than 25% of cells. aCGH detected 44 additional abnormalities undetected or misidentified by karyotype, 21 subsequently validated by FISH, including abnormalities in 4 of 10 cases with uninformative cytogenetics. aCGH detected concurrent terminal deletions of both 9p and 20q in three cases, in two of which the 20q deletion was undetected by karyotype. A narrow region of loss at 7p21 was detected in two cases. Conclusions An array with increased BAC density over regions important in ALL, combined with PCR for fusion products of balanced translocations, could minimize labor- and time-intensive cytogenetic assays and provide key prognostic information in the approximately 35% of cases with uninformative cytogenetics. PMID:18253961

  18. SAMPIE (Solar Array Module Plasma Interactions Experiment). (Videotape)

    SciTech Connect

    Not Available

    1994-02-01

    SAMPIE is an in-space technology experiment that flew on STS-62. Its intent is to investigate the potentially damaging effects of space plasma (gases) on different types, sizes, and shapes of solar cells, solar modules, and spacecraft materials.

  19. Island Divertor Plate Modeling for the Compact Toroidal Hybrid Experiment

    NASA Astrophysics Data System (ADS)

    Hartwell, G. J.; Massidda, S. D.; Ennis, D. A.; Knowlton, S. F.; Maurer, D. A.; Bader, A.

    2015-11-01

    Edge magnetic island divertors can be used as a method of plasma particle and heat exhaust in long pulse stellarator experiments. Detailed power loading on these structures and its relationship to the long connection length scrape off layer physics is a new Compact Toroidal Hybrid (CTH) research thrust. CTH is a five field period, l = 2 torsatron with R0 = 0 . 75 m, ap ~ 0 . 2 m, and | B | <= 0 . 7 T. For these studies CTH is configured as a pure stellarator using a 28 GHz, 200 kW gyrotron operating at 2nd harmonic for ECRH. We report the results of EMC3-EIRENE modeling of divertor plates near magnetic island structures. The edge rotational transform is varied by adjusting the ratio of currents in the helical and toroidal field coils. A poloidal field coil adjusts the shear of the rotational transform profile, and width of the magnetic island, while the phase of the island is rotated with a set of five error coils producing an n = 1 perturbation. For the studies conducted, a magnetic configuration with a large n = 1 , m = 3 magnetic island at the edge is generated. Results from multiple potential divertor plate locations will be presented and discussed. This work is supported by U.S. Department of Energy Grant No. DE-FG02-00ER54610.

  20. In-Space Structural Validation Plan for a Stretched-Lens Solar Array Flight Experiment

    NASA Technical Reports Server (NTRS)

    Pappa, Richard S.; Woods-Vedeler, Jessica A.; Jones, Thomas W.

    2001-01-01

    This paper summarizes in-space structural validation plans for a proposed Space Shuttle-based flight experiment. The test article is an innovative, lightweight solar array concept that uses pop-up, refractive stretched-lens concentrators to achieve a power/mass density of at least 175 W/kg, which is more than three times greater than current capabilities. The flight experiment will validate this new technology to retire the risk associated with its first use in space. The experiment includes structural diagnostic instrumentation to measure the deployment dynamics, static shape, and modes of vibration of the 8-meter-long solar array and several of its lenses. These data will be obtained by photogrammetry using the Shuttle payload-bay video cameras and miniature video cameras on the array. Six accelerometers are also included in the experiment to measure base excitations and small-amplitude tip motions.

  1. Gyrotron experiments employing a field emission array cathode

    SciTech Connect

    Garven, M.; Cooke, S.J.; Cross, A.W.; Phelps, A.D.R.; Spark, S.N.

    1995-12-31

    The design and operation of a field emission array (FEA) cathode for a millimeter wave gyrotron are presented. The FEA chip employed achieved 10mA reproducibly while operating in the environment of a gyrotron, namely in a vacuum of 1 {times} 10{sup {minus}8} mbar at voltages of up to 40kV. New methods are presented of mounting such FEA chips involving the shielding of the micron devices from voltages of up to 40kV, as experienced in a microwave device. The design parameters of the FEA gun were similar to those of a magnetron injection gun with cathode radius 12.5mm and slope angle 4{degree}. An electron beam current of up to 100mA was achievable from the FEA gyrotron cathode. An electrically isolated, fiber-optic, 10-channel control unit was developed to allow individual control of each chip. Electron beam powers of {approximately} 1kW were measured from the FEA cathode. To obtain oscillation, cavity inserts were employed in the electron beam-microwave interaction region to increase the cavity quality factor. Results are presented which verify the gyrotron interaction from the novel FEA cathode.

  2. Carbon-coated silicon nanotube arrays on carbon cloth as a hybrid anode for lithium-ion batteries

    NASA Astrophysics Data System (ADS)

    Wang, Wei; Gu, Lin; Qian, Haolei; Zhao, Ming; Ding, Xi; Peng, Xinsheng; Sha, Jian; Wang, Yewu

    2016-03-01

    Silicon hollow nanostructure has been considered as one of the most promising material for commercial application in lithium-ion batteries due to its significant improvement of cycling stability. The fabricated hybrid structures, carbon-coated silicon nanotube arrays on carbon cloth substrate, with a high surface area and short electron collection pathway have been directly used as anode electrodes without any additional binder. The electrodes exhibit high capacity, excellent rate capability and good cycling stability. The discharge capacity of the hybrid electrode (the deposition time of silicon shell: 5 min) keeps stable, and after 100 cycles, the discharge capacities still remain 3654 mAh g-1 at the rate of 0.5 C.

  3. FeOOH/Co/FeOOH Hybrid Nanotube Arrays as High-Performance Electrocatalysts for the Oxygen Evolution Reaction.

    PubMed

    Feng, Jin-Xian; Xu, Han; Dong, Yu-Tao; Ye, Sheng-Hua; Tong, Ye-Xiang; Li, Gao-Ren

    2016-03-01

    Herein, we developed FeOOH/Co/FeOOH hybrid nanotube arrays (HNTAs) supported on Ni foams for oxygen evolution reaction (OER). The inner Co metal cores serve as highly conductive layers to provide reliable electronic transmission, and can overcome the poor electrical conductivity of FeOOH efficiently. DFT calculations demonstrate the strong electronic interactions between Co and FeOOH in the FeOOH/Co/FeOOH HNTAs, and the hybrid structure can lower the energy barriers of intermediates and thus promote the catalytic reactions. The FeOOH/Co/FeOOH HNTAs exhibit high electrocatalytic performance for OER, such as low onset potential, small Tafel slope, and excellent long-term durability, and they are promising electrocatalysts for OER in alkaline solution. PMID:26879125

  4. A hybrid finite element method for scattering and radiation by microstrip patch antennas and arrays residing in a cavity

    NASA Astrophysics Data System (ADS)

    Jin, Jian-Ming; Volakis, John L.

    1991-11-01

    A hybrid numerical technique is presented for a characterization of the scattering and radiation properties of microstrip patch antennas and arrays residing in a cavity recessed in a ground plane. The technique combines the finite-element and boundary integral methods to formulate a system for the solution of the fields at the aperture and those inside the cavity via the biconjugate gradient method in conjunction with the fast Fourier transform (FFT). By virtue of the finite-element method, the proposed technique is applicable to patch antennas and arrays residing on or embedded in a layered dielectric substrate and is also capable of treating various feed configurations and impedance loads. Several numerical results are presented, demonstrating the validity, efficiency, and capability of the technique.

  5. Underwater imaging using a hybrid Kirchhoff migration: direction of arrival method and a sparse surface sensor array.

    PubMed

    Dord, Jean-Francois; Farhat, Charbel

    2010-08-01

    This paper considers the problem of imaging a complex object submerged in shallow waters using a sparse surface sensor array and a hybrid signal processing method. This method is constructed by refining the Kirchhoff migration technique to incorporate a zoning of the sensors and an analysis of multiple reflections, and combining it with the direction of arrival estimation method. Its performance is assessed and analyzed with the shape identification of a mockup submarine by numerical simulation. The obtained numerical results highlight the potential of this approach for identifying underwater intruders. PMID:20707441

  6. Direct photofabrication of focal-length-controlled microlens array using photoinduced migration mechanisms of photosensitive sol-gel hybrid materials

    NASA Astrophysics Data System (ADS)

    Kang, Dong Jun; Jeong, Jong-Pil; Bae, Byeong-Soo

    2006-09-01

    Photosensitive sol-gel hybrid (SGH) materials exhibited the peculiar photoinduced migration behavior of unreacted molecules from unexposed areas to exposed areas by selective UV exposure. Using the photoinduced migration mechanism of the photosensitive SGH materials, the microlens array (MLA) with a smooth surface was directly photofabricated, and the focal length was controlled by changing the photoinduced migration parameters. The higher photoactive monomer content and the thicker film creating a higher curvature produced a smaller focal length of the MLA. Thus, a simple fabrication and easy control of the focal length can be applicable to a fabrication of an efficient MLA.

  7. Prenatal diagnosis of chromosomal abnormalities using array-based comparative genomic hybridization

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This study was designed to evaluate the feasibility of using a targeted array-CGH strategy for prenatal diagnosis of genomic imbalances in a clinical setting of current pregnancies. Women undergoing prenatal diagnosis were counseled and offered array-CGH (BCM V4.0) in addition to routine chromosome ...

  8. Ka-band MMIC array system for ACTS aeronautical terminal experiment (Aero-X)

    NASA Technical Reports Server (NTRS)

    Raquet, Charles A.; Zakrajsek, Robert J.; Lee, Richard Q.; Andro, Monty; Turtle, John P.

    1995-01-01

    During the summer of 1994, the Advanced Communication Technology Satellite (ACTS) Aeronautical Terminal Experiment (Aero-X) was successfully completed by the NASA Lewis Research Center (LeRC) and the Jet Propulsion Laboratory (JPL). 4.8 and 9.6 Kbps duplex voice links were established between the LeRC Learjet and the ACTS Link Evaluation Terminal (LET) in Cleveland, Ohio, via the ACTS. The antenna system used in this demonstration was developed by LeRC and featured LeRC and US Air Force experimental arrays using GaAs MMIC devices at each radiating element for electronic beam steering and distributed power amplification. The antenna system consisted of three arrays mounted inside the LeRC Learjet, pointing out through the windows. An open loop tracking controller developed by LeRC used information from the aircraft position and attitude sensors to automatically steer the arrays toward ACTS during flight JPL ACTS Mobile Terminal (AMT) system hardware was used as transceivers both on the aircraft and at the LET. The single 32 element MMIC transmit array developed by NASA/LeRC and Texas Instruments has an EIRP of 23.4 dBW at boresight. The two 20 GHz MMIC receive arrays were developed in a cooperative effort with the USAF Rome Laboratory/Electronic System Center, taking advantage of existing USAF array development contracts with Boeing and Martin Marietta. The Boeing array has 23 elements and a G/T of 16/6 db/degK at boresight. The Martin Marietta array has 16 elements and a G/T of 16.1 db/degK at boresight. The three proof-of-concept arrays, the array control system and their integration and operation in the Learjet for Aero-X are described.

  9. A hybrid antenna array design for 3-d direction of arrival estimation.

    PubMed

    Saqib, Najam-Us; Khan, Imdad

    2015-01-01

    A 3-D beam scanning antenna array design is proposed that gives a whole 3-D spherical coverage and also suitable for various radar and body-worn devices in the Body Area Networks applications. The Array Factor (AF) of the proposed antenna is derived and its various parameters like directivity, Half Power Beam Width (HPBW) and Side Lobe Level (SLL) are calculated by varying the size of the proposed antenna array. Simulations were carried out in MATLAB 2012b. The radiators are considered isotropic and hence mutual coupling effects are ignored. The proposed array shows a considerable improvement against the existing cylindrical and coaxial cylindrical arrays in terms of 3-D scanning, size, directivity, HPBW and SLL. PMID:25790103

  10. Exploring PV on the Red Planet: Mars Array Technology Experiment and Dust Accumulation and Removal Technology

    NASA Technical Reports Server (NTRS)

    Landis, Geoffrey A.; Baraona, Cosmo; Brinker, David; Schelman, David

    2004-01-01

    The environment on the surface of Mars is different in several critical ways from the orbital environment in which space solar arrays normally operate. Some important differences are: 1) Low intensity, low temperature operation; 2) Spectrum modified by atmospheric dust, varies with time; 3) Indirect sunlight; 4) Possibility of dust atoms at some times of year; 5) Deposited dust; 6) Wind; 7) Peroxide-rich reactive soil. We are developing two experiments to test operation of solar arrays on the surface of Mars, to be flown on the 2001 Surveyor Lander mission. The Mars Array Technology Experiment (MATE) will test the operation of several types of solar cells under Mars conditions, and determine the direct and scattered solar spectrum at the surface. The Dust Accumulation and Removal Technology (DART) experiment will monitor the amount of dust deposition on a target solar cell, measure the characteristics of the dust, and test the feasibility of dust removal.

  11. Designing a Hybrid Laminar-Flow Control Experiment: The CFD-Experiment Connection

    NASA Technical Reports Server (NTRS)

    Streett, C. L.

    2003-01-01

    The NASA/Boeing hybrid laminar flow control (HLFC) experiment, designed during 1993-1994 and conducted in the NASA LaRC 8-foot Transonic Pressure Tunnel in 1995, utilized computational fluid dynamics and numerical simulation of complex fluid mechanics to an unprecedented extent for the design of the test article and measurement equipment. CFD was used in: the design of the test wing, which was carried from definition of desired disturbance growth characteristics, through to the final airfoil shape that would produce those growth characteristics; the design of the suction-surface perforation pattern that produced enhanced crossflow-disturbance growth: and in the design of the hot-wire traverse system that produced minimal influence on measured disturbance growth. These and other aspects of the design of the test are discussed, after the historical and technical context of the experiment is described.

  12. Preliminary results from the flight of the Solar Array Module Plasma Interactions Experiment (SAMPIE)

    NASA Technical Reports Server (NTRS)

    Ferguson, Dale C.; Hillard, G. Barry

    1994-01-01

    SAMPIE, the Solar Array Module Plasma Interactions Experiment, flew in the Space Shuttle Columbia payload bay as part of the Office of Aeronautics and Space Technology-2 (OAST-2) mission on STS-62, March, 1994. SAMPIE biased samples of solar arrays and space power materials to varying potentials with respect to the surrounding space plasma, and recorded the plasma currents collected and the arcs which occurred, along with a set of plasma diagnostics data. A large set of high quality data was obtained on the behavior of solar arrays and space power materials in the space environment. This paper is the first report on the data SAMPIE telemetered to the ground during the mission. It will be seen that the flight data promise to help determine arcing thresholds, snapover potentials, and floating potentials for arrays and spacecraft in LEO.

  13. Preliminary results from the flight of the Solar Array Module Plasma Interactions Experiment (SAMPIE)

    SciTech Connect

    Ferguson, D.C.; Hillard, G.B.

    1994-09-01

    SAMPIE, the Solar Array Module Plasma Interactions Experiment, flew in the Space Shuttle Columbia payload bay as part of the Office of Aeronautics and Space Technology-2 (OAST-2) mission on STS-62, March, 1994. SAMPIE biased samples of solar arrays and space power materials to varying potentials with respect to the surrounding space plasma, and recorded the plasma currents collected and the arcs which occurred, along with a set of plasma diagnostics data. A large set of high quality data was obtained on the behavior of solar arrays and space power materials in the space environment. This paper is the first report on the data SAMPIE telemetered to the ground during the mission. It will be seen that the flight data promise to help determine arcing thresholds, snapover potentials, and floating potentials for arrays and spacecraft in LEO.S

  14. Extending Learning beyond the Classroom: Graduate Student Experiences of Online Discussions in a Hybrid Course

    ERIC Educational Resources Information Center

    Sullivan, Timothy M.; Freishtat, Richard

    2013-01-01

    While a range of research has been done on hybrid learning and online discussions, few studies have examined the voice of students in regard to their perceptions of these types of learning experiences. This article presents current research findings gathered from part-time graduate students enrolled in a hybrid course. The students' perceptions…

  15. Threshold Energy Density of Lower Hybrid Waves in the Freja Experiment

    SciTech Connect

    Popel, S. I.

    2001-05-15

    Data from the Freja satellite experiment on the lower hybrid turbulence in the Earth's magnetosphere are analyzed. It is shown that the observed threshold energy density of lower hybrid waves required for the excitation of localized wave packets is in good agreement with theoretical predictions.

  16. Platinum nanoparticles-single-walled carbon nanotubes hybrid based chemiresistive sensor array for myoglobin detection

    NASA Astrophysics Data System (ADS)

    Sharma, Vikash; Puri, Nitin K.; Mulchandani, Ashok; Rajesh

    2016-03-01

    We examined the potential of platinum nanoparticles (PtNP) modified single-walled carbon nanotube (SWNT) hybrid chemiresistive sensor for detection of antigen myoglobin (Mb) in phosphate buffer saline. Protein antibody, Ab-Mb, was covalently immobilized through site specific binding on PtNP attached over SWNT. A concentration-dependent change in the source-drain current of the hybrid device was observed in the range of 0.1-1000 ng ml-1. The hybrid device response fitted well with the Hill-Langmuir equation with a maximum response of 111.14% and low dissociation constant value (K d = 19.98 ng ml-1), indicating high protein antigen binding affinity at hybrid nanostructure.

  17. Towards a cellular multi-parameter analysis platform: fluorescence in situ hybridization (FISH) on microhole-array chips.

    PubMed

    Kurz, Christian M; Moosdijk, Stefan V D; Thielecke, Hagen; Velten, Thomas

    2011-01-01

    Highly-sensitive analysis systems based on cellular multi-parameter are needed in the diagnostics. Therefore we improved our previously developed chip platform for another additional analysis method, the fluorescence in situ hybridization. Fluorescence in situ hybridization (FISH) is a technique used in the diagnostics to determine the localization and the presence or absence of specific DNA sequence. To improve this labor- and cost-intensive method, we reduced the assay consumption by a factor of 5 compared to the standard protocol. Microhole chips were used for making the cells well addressable. The chips were fabricated by semiconductor technology on the basis of a Silicon wafer with a thin deposited silicon nitride layer (Si(3)N(4)). Human retina pigment epithelia (ARPE-19) cells were arrayed on 5-μm holes of a 35 × 35 microhole-array by a gently negative differential pressure of around 5 mbar. After 3 hours of incubation the cells were attached to the chip and the FISH protocol was applied to the positioned cells. A LabView software was developed to simplify the analysis. The software automatically counts the number of dots (positive labeled chromosome regions) as well as the distance between adjacent dots. Our developed platform reduces the assay consumption and the labor time. Furthermore, during the 3 hours of incubation non-invasive or minimal-invasive methods like Raman- and impedance-spectroscopy can be applied. PMID:22256298

  18. Method for producing a hybridization of detector array and integrated circuit for readout

    NASA Technical Reports Server (NTRS)

    Fossum, Eric R. (Inventor); Grunthaner, Frank J. (Inventor)

    1993-01-01

    A process is explained for fabricating a detector array in a layer of semiconductor material on one substrate and an integrated readout circuit in a layer of semiconductor material on a separate substrate in order to select semiconductor material for optimum performance of each structure, such as GaAs for the detector array and Si for the integrated readout circuit. The detector array layer is lifted off its substrate, laminated on the metallized surface on the integrated surface, etched with reticulating channels to the surface of the integrated circuit, and provided with interconnections between the detector array pixels and the integrated readout circuit through the channels. The adhesive material for the lamination is selected to be chemically stable to provide electrical and thermal insulation and to provide stress release between the two structures fabricated in semiconductor materials that may have different coefficients of thermal expansion.

  19. A new adaptive hybrid electromagnetic damper: modelling, optimization, and experiment

    NASA Astrophysics Data System (ADS)

    Asadi, Ehsan; Ribeiro, Roberto; Behrad Khamesee, Mir; Khajepour, Amir

    2015-07-01

    This paper presents the development of a new electromagnetic hybrid damper which provides regenerative adaptive damping force for various applications. Recently, the introduction of electromagnetic technologies to the damping systems has provided researchers with new opportunities for the realization of adaptive semi-active damping systems with the added benefit of energy recovery. In this research, a hybrid electromagnetic damper is proposed. The hybrid damper is configured to operate with viscous and electromagnetic subsystems. The viscous medium provides a bias and fail-safe damping force while the electromagnetic component adds adaptability and the capacity for regeneration to the hybrid design. The electromagnetic component is modeled and analyzed using analytical (lumped equivalent magnetic circuit) and electromagnetic finite element method (FEM) (COMSOL® software package) approaches. By implementing both modeling approaches, an optimization for the geometric aspects of the electromagnetic subsystem is obtained. Based on the proposed electromagnetic hybrid damping concept and the preliminary optimization solution, a prototype is designed and fabricated. A good agreement is observed between the experimental and FEM results for the magnetic field distribution and electromagnetic damping forces. These results validate the accuracy of the modeling approach and the preliminary optimization solution. An analytical model is also presented for viscous damping force, and is compared with experimental results The results show that the damper is able to produce damping coefficients of 1300 and 0-238 N s m-1 through the viscous and electromagnetic components, respectively.

  20. Relative performance of hybrid nestlings in Ficedula flycatchers: a translocation experiment.

    PubMed

    Vallin, Niclas; Nonaka, Yuki; Feng, Jue; Qvarnström, Anna

    2013-02-01

    Ecological speciation predicts that hybrids should experience relatively low fitness in the local environments of their parental species. In this study, we performed a translocation experiment of nestling hybrids between collared and pied flycatchers into the nests of conspecific pairs of their parental species. Our aim was to compare the performance of hybrids with purebred nestlings. Nestling collared flycatchers are known to beg and grow faster than nestling pied flycatchers under favorable conditions, but to experience higher mortality than nestling pied flycatchers under food limitation. The experiment was performed relatively late in the breeding season when food is limited. If hybrid nestlings have an intermediate growth potential and begging intensity, we expected them to beg and grow faster, but also to experience lower survival than pied flycatchers. In comparison with nestling collared flycatchers, we expected them to beg and grow slower, but to survive better. We found that nestling collared flycatchers indeed begged significantly faster and experienced higher mortality than nestling hybrids. Moreover, nestling hybrids had higher weight and tended to beg faster than nestling pied flycatchers, but we did not detect a difference in survival between the latter two groups of nestlings. We conclude that hybrid Ficedula nestlings appear to have a better intrinsic adaptation to food limitation late in the breeding season compared with nestling collared flycatchers. We discuss possible implications for gene flow between the two species. PMID:23467681

  1. Metal-organic framework derived hybrid Co3O4-carbon porous nanowire arrays as reversible oxygen evolution electrodes.

    PubMed

    Ma, Tian Yi; Dai, Sheng; Jaroniec, Mietek; Qiao, Shi Zhang

    2014-10-01

    Hybrid porous nanowire arrays composed of strongly interacting Co3O4 and carbon were prepared by a facile carbonization of the metal-organic framework grown on Cu foil. The resulting material, possessing a high surface area of 251 m(2) g(-1) and a large carbon content of 52.1 wt %, can be directly used as the working electrode for oxygen evolution reaction without employing extra substrates or binders. This novel oxygen evolution electrode can smoothly operate in alkaline solutions (e.g., 0.1 and 1.0 M KOH), affording a low onset potential of 1.47 V (vs reversible hydrogen electrode) and a stable current density of 10.0 mA cm(-2) at 1.52 V in 0.1 M KOH solution for at least 30 h, associated with a high Faradaic efficiency of 99.3%. The achieved ultrahigh oxygen evolution activity and strong durability, with superior performance in comparison to the state-of-the-art noble-metal/transition-metal and nonmetal catalysts, originate from the unique nanowire array electrode configuration and in situ carbon incorporation, which lead to the large active surface area, enhanced mass/charge transport capability, easy release of oxygen gas bubbles, and strong structural stability. Furthermore, the hybrid Co3O4-carbon porous nanowire arrays can also efficiently catalyze oxygen reduction reaction, featuring a desirable four-electron pathway for reversible oxygen evolution and reduction, which is potentially useful for rechargeable metal-air batteries, regenerative fuel cells, and other important clean energy devices. PMID:25216300

  2. Hybrid Li-air battery cathodes with sparse carbon nanotube arrays directly grown on carbon fiber papers

    SciTech Connect

    Li, YF; Huang, ZP; Huang, K; Carnahan, D; Xing, YC

    2013-11-01

    Sparsely populated, vertically aligned nitrogen doped carbon nanotube arrays (CNTAs) with dislocated-graphene stacking were grown directly on carbon fiber papers and investigated as hierarchical air cathodes in hybrid Li-air batteries with aqueous catholytes. The CNTAs were made with electrodeposited Ni nanocatalysts, followed by plasma-enhanced chemical vapor deposition. The thus obtained CNTAs can reach a population number density as low as similar to 10(7) per cm(2) on the carbon fibers, achieving an extremely high porosity of over 99% for the active layer in the cathode. The sparse CNTAs not only provide effective pathways for the reacting species, but also show a significantly high catalytic activity, which is found to be comparable to that of a supported Pt electrocatalyst. The high activity of the CNTAs is attributed to the rich graphene edges exposed on the CNT surface and nitrogen doping. Hybrid Li-air batteries with such cathodes have shown a consistent discharging capacity of 710 mA h g(-1) and a specific energy of 2057 W h kg(-1) at 0.5 mA cm(-2). Stable charge-discharge cycling at 0.5 mA cm(-2) showed an average potential difference of 1.35 V, indicative of a relatively small overpotential and high round trip efficiency (71%). Furthermore, the hybrid Li-air battery based on the hierarchical cathode can reach a power density as high as 10.4 mW cm(-2).

  3. Case for a field-programmable gate array multicore hybrid machine for an image-processing application

    NASA Astrophysics Data System (ADS)

    Rakvic, Ryan N.; Ives, Robert W.; Lira, Javier; Molina, Carlos

    2011-01-01

    General purpose computer designers have recently begun adding cores to their processors in order to increase performance. For example, Intel has adopted a homogeneous quad-core processor as a base for general purpose computing. PlayStation3 (PS3) game consoles contain a multicore heterogeneous processor known as the Cell, which is designed to perform complex image processing algorithms at a high level. Can modern image-processing algorithms utilize these additional cores? On the other hand, modern advancements in configurable hardware, most notably field-programmable gate arrays (FPGAs) have created an interesting question for general purpose computer designers. Is there a reason to combine FPGAs with multicore processors to create an FPGA multicore hybrid general purpose computer? Iris matching, a repeatedly executed portion of a modern iris-recognition algorithm, is parallelized on an Intel-based homogeneous multicore Xeon system, a heterogeneous multicore Cell system, and an FPGA multicore hybrid system. Surprisingly, the cheaper PS3 slightly outperforms the Intel-based multicore on a core-for-core basis. However, both multicore systems are beaten by the FPGA multicore hybrid system by >50%.

  4. Validation of the Agilent 244K oligonucleotide array-based comparative genomic hybridization platform for clinical cytogenetic diagnosis.

    PubMed

    Yu, Shihui; Bittel, Douglas C; Kibiryeva, Nataliya; Zwick, David L; Cooley, Linda D

    2009-09-01

    High-resolution microarray comparative genomic hybridization (aCGH) is being adopted for diagnostic evaluation of genomic disorders, but validation for clinical diagnosis has not yet been reported. We present validation data for the Agilent Human Genome Microarray Kit 244K for clinical application. The platform contains approximately 240,000 distinct 60-mer oligonucleotide probes spanning the entire human genome. We studied 45 previously characterized samples (43 abnormal, 2 normal), 32 with knowledge of prior results and 13 in a blinded manner with 11 performed in a reference laboratory providing microarray testing. Array analysis confirmed known aberrations in 43 samples and a normal result in 2. The array analysis corrected 1 karyotype and clarified 2 additional cases. Array data from 6 patients with 22q11.2 deletion found an average of 2.56 megabases (Mb; range, 2.49-2.62 Mb) with a common 2.43-Mb deleted region. Approximately 7 copy number variants from 400 base pairs to 1.6 Mb were identified per sample. Results demonstrate the usefulness of the aCGH-244K platform as a powerful diagnostic tool. PMID:19687311

  5. Characterization of genomic alterations in radiation-associated breast cancer among childhood cancer survivors, using comparative genomic hybridization (CGH) arrays.

    PubMed

    Yang, Xiaohong R; Killian, J Keith; Hammond, Sue; Burke, Laura S; Bennett, Hunter; Wang, Yonghong; Davis, Sean R; Strong, Louise C; Neglia, Joseph; Stovall, Marilyn; Weathers, Rita E; Robison, Leslie L; Bhatia, Smita; Mabuchi, Kiyohiko; Inskip, Peter D; Meltzer, Paul

    2015-01-01

    Ionizing radiation is an established risk factor for breast cancer. Epidemiologic studies of radiation-exposed cohorts have been primarily descriptive; molecular events responsible for the development of radiation-associated breast cancer have not been elucidated. In this study, we used array comparative genomic hybridization (array-CGH) to characterize genome-wide copy number changes in breast tumors collected in the Childhood Cancer Survivor Study (CCSS). Array-CGH data were obtained from 32 cases who developed a second primary breast cancer following chest irradiation at early ages for the treatment of their first cancers, mostly Hodgkin lymphoma. The majority of these cases developed breast cancer before age 45 (91%, n = 29), had invasive ductal tumors (81%, n = 26), estrogen receptor (ER)-positive staining (68%, n = 19 out of 28), and high proliferation as indicated by high Ki-67 staining (77%, n = 17 out of 22). Genomic regions with low-copy number gains and losses and high-level amplifications were similar to what has been reported in sporadic breast tumors, however, the frequency of amplifications of the 17q12 region containing human epidermal growth factor receptor 2 (HER2) was much higher among CCSS cases (38%, n = 12). Our findings suggest that second primary breast cancers in CCSS were enriched for an "amplifier" genomic subgroup with highly proliferative breast tumors. Future investigation in a larger irradiated cohort will be needed to confirm our findings. PMID:25764003

  6. Dual-facet coupling of SOA array on 4-μm silicon-on-insulator implementing a hybrid integrated SOA-MZI wavelength converter

    NASA Astrophysics Data System (ADS)

    Alexoudi, T.; Fitsios, D.; Kanellos, G. T.; Pleros, N.; Tekin, T.; Cherchi, M.; Ylinen, S.; Harjanne, M.; Kapulainen, M.; Aalto, T.

    2014-03-01

    Hybrid integration on Silicon-on-Insulator (SOI) has emerged as a practical solution for compact and high-performance Photonic Integrated Circuits (PICs). It aims at combining the cost-effectiveness and CMOS-compatibility benefits of the low-loss SOI waveguide platform with the versatile active optical functions that can be realized by III-V photonic materials. The utilization of SOI, as an integration board, with μm-scale dimensions allows for an excellent optical mode matching between silicon rib waveguides and active chips, allowing for minimal-loss coupling of the pre-fabricated IIIV components. While dual-facet coupling as well as III-V multi-element array bonding should be employed to enable enhanced active on-chip functions, so far only single side SOA bonding has been reported. In the present communication, we present a novel integration scheme that flip-chip bonds a 6-SOA array on 4-μm thick SOI technology by coupling both lateral SOA facets to the waveguides, and report on the experimental results of wavelength conversion operation of a dual-element Semiconductor Optical Amplifier - Mach Zehnder Interferometer (SOA-MZI) circuit. Thermocompression bonding was applied to integrate the pre-fabricated SOAs on SOI, with vertical and horizontal alignment performed successfully at both SOA facets. The demonstrated device has a footprint of 8.2mm x 0.3mm and experimental evaluation revealed a 12Gb/s wavelength conversion operation capability with only 0.8dB power penalty for the first SOA-MZI-on-SOI circuit and a 10Gb/s wavelength conversion operation capability with 2 dB power penalty for the second SOA-MZI circuit. Our experiments show how dual facet integration can significantly increase the level of optical functionalities achievable by flip-chip hybrid technology and pave the way for more advanced and more densely PICs.

  7. Hybrid simulation of the Z-pinch instabilities for profiles generated during wire array implosion in the Saturn pulsed power generator

    SciTech Connect

    Sotnikov, V.I.; Leboeuf, J.N.; Deeney, C.; Coverdale, C.A.; Hellinger, P.; Travnicek, P.; Fiala, V.

    2005-09-15

    Experimental evidence suggests that the energy balance between processes in play during wire array implosions is not well understood. In fact the radiative yields can exceed by several times the implosion kinetic energy. A possible explanation is that the coupling from magnetic energy to kinetic energy as magnetohydrodynamic plasma instabilities develop provides additional energy. It is thus important to model the instabilities produced in the after implosion stage of the wire array in order to determine how the stored magnetic energy can be connected with the radiative yields. To this aim three-dimensional hybrid simulations have been performed. They are initialized with plasma radial density profiles, deduced in recent experiments [C. Deeney et al., Phys. Plasmas 6, 3576 (1999)] that exhibited large x-ray yields, together with the corresponding magnetic field profiles. Unlike previous work, these profiles do not satisfy pressure balance and differ substantially from those of a Bennett equilibrium. They result in faster growth with an associated transfer of magnetic energy to plasma motion and hence kinetic energy.

  8. Hybrid simulation of the Z-pinch instabilities for profiles generated in the process of wire array implosion in the Saturn pulsed power generator.

    SciTech Connect

    Coverdale, Christine Anne; Travnicek, P.; Hellinger, P.; Fiala, V.; Leboeuf, J. N.; Deeney, Christopher; Sotnikov, Vladimir Isaakovich

    2005-02-01

    Experimental evidence suggests that the energy balance between processes in play during wire array implosions is not well understood. In fact the radiative yields can exceed by several times the implosion kinetic energy. A possible explanation is that the coupling from magnetic energy to kinetic energy as magnetohydrodynamic plasma instabilities develop provides additional energy. It is thus important to model the instabilities produced in the after implosion stage of the wire array in order to determine how the stored magnetic energy can be connected with the radiative yields. To this aim three-dimensional hybrid simulations have been performed. They are initialized with plasma radial density profiles, deduced in recent experiments [C. Deeney et al., Phys. Plasmas 6, 3576 (1999)] that exhibited large x-ray yields, together with the corresponding magnetic field profiles. Unlike previous work, these profiles do not satisfy pressure balance and differ substantially from those of a Bennett equilibrium. They result in faster growth with an associated transfer of magnetic energy to plasma motion and hence kinetic energy.

  9. Referencing cross-reactivity of detection antibodies for protein array experiments

    PubMed Central

    Lemass, Darragh; O'Kennedy, Richard; Kijanka, Gregor S.

    2016-01-01

    Protein arrays are frequently used to profile antibody repertoires in humans and animals. High-throughput protein array characterisation of complex antibody repertoires requires a platform-dependent, lot-to-lot validation of secondary detection antibodies. This article details the validation of an affinity-isolated anti-chicken IgY antibody produced in rabbit and a goat anti-rabbit IgG antibody conjugated with alkaline phosphatase using protein arrays consisting of 7,390 distinct human proteins. Probing protein arrays with secondary antibodies in absence of chicken serum revealed non-specific binding to 61 distinct human proteins. The cross-reactivity of the tested secondary detection antibodies points towards the necessity of platform-specific antibody characterisation studies for all secondary immunoreagents. Secondary antibody characterisation using protein arrays enables generation of reference lists of cross-reactive proteins, which can be then excluded from analysis in follow-up experiments. Furthermore, making such cross-reactivity lists accessible to the wider research community may help to interpret data generated by the same antibodies in applications not related to protein arrays such as immunoprecipitation, Western blots or other immunoassays. PMID:27335636

  10. Impact of LDEF photovoltaic experiment findings upon spacecraft solar array design and development requirements

    NASA Technical Reports Server (NTRS)

    Young, Leighton E.

    1993-01-01

    Photovoltaic cells (solar cells) and other solar array materials were flown in a variety of locations on the Long Duration Exposure Facility (LDEF). With respect to the predicted leading edge, solar array experiments were located at 0 degrees (row 9), 30 degrees (row 8) and 180 degrees (row 3). Postflight estimates of location of the experiments with respect to the velocity vector add 8.1 degrees to these values. Experiments were also located on the Earth end of the LDEF longitudinal axis. Types and magnitudes of detrimental effects differ between the locations with some commonality. Postflight evaluation of the solar array experiments reveal that some components/materials are very resistant to the environment to which they were exposed while others need protection, modification, or replacement. Interaction of materials with atomic oxygen (AO), as an area of major importance, was dramatically demonstrated by LDEF results. Information gained from the LDEF flight allows array developers to set new requirements for on-going and future technology and flight component development.

  11. Generation of Localized Surface Plasmon Resonance Using Hybrid Au-Ag Nanoparticle Arrays as a Sensor of Polychlorinated Biphenyls Detection.

    PubMed

    Liu, Jing; Cai, Haoyuan; Chen, Chaoyang; Yang, Guangsong; Yang, Cheng-Fu

    2016-01-01

    In this study, the hybrid Au-Ag hexagonal lattice of triangular and square lattice of quadrate periodic nanoparticle arrays (PNAs) were designed to investigate their extinction spectra of the localized surface plasmon resonances (LSPRs). First, their simulating extinction spectra were calculated by discrete dipole approximation (DDA) numerical method by changing the media refractive index. Simulation results showed that as the media refractive index was changed from 1.0 to 1.2, the maximum peak intensity of LSPRs spectra had no apparent change and the wavelength to reveal the maximum peak intensity of LSPRs spectra was shifted lower value. Polystyrene (PS) nanospheres with two differently arranged structures were used as the templates to deposit the hybrid Au-Ag hexagonal lattice of triangular and square lattice of quadrate periodic PNAs by evaporation method. The hybrid Au-Ag hexagonal lattice of triangular and square lattice of quadrate PNAs were grown on single crystal silicon (c-Si) substrates, and their measured extinction spectra were compared with the calculated results. Finally, the fabricated hexagonal lattices of triangular PNAs were investigated as a sensor of polychlorinated biphenyl solution (PCB-77) by observing the wavelength to reveal the maximum extinction efficiency (λmax). We show that the adhesion of β-cyclodextrins (SH-β-CD) on the hybrid Au-Ag hexagonal lattice of triangular PNAs could be used to increase the variation of λmax. We also demonstrate that the adhesion of SH-β-CD increases the sensitivity and detection effect of PCB-77 in hexagonal lattice of triangular PNAs. PMID:27527188

  12. Hybrid technique for postoperative ventral hernias – own experience

    PubMed Central

    Okniński, Tomasz; Pawlak, Jacek

    2015-01-01

    Introduction There are many techniques which may be involved in abdominal hernia repair, from classical to tension-free. Treatment of complicated hernias has undergone evolution. Many surgeons consider the laparoscopic method as a method of choice for incisional hernia repair. Sometimes miniinvasive repair of complicated hernia is not so easy to perform. We are convinced that selected patients may benefit from combined open and laparoscopic techniques. Aim To present the operating technique and early results of treatment of 15 patients operated on using the 3 hybrid technique. Material and methods Fifteen patients suffering from recurrent incisional hernias underwent the hybrid technique for their repair between June 2012 and April 2015. The hybrid technique was performed using synthetic meshes in 14 cases and a biological implant in 1 case. Results The early postoperative period was uncomplicated in all cases. Within a maximum follow-up period of 32 months, two deep wound infections were observed. Conclusions The hybrid technique may be used in patients with recurrent incisional hernias. PMID:26865889

  13. Opto- μECoG array: a hybrid neural interface with transparent μECoG electrode array and integrated LEDs for optogenetics.

    PubMed

    Kwon, Ki Yong; Sirowatka, Brenton; Weber, Arthur; Li, Wen

    2013-10-01

    Electrocorticogram (ECoG) recordings, taken from electrodes placed on the surface of the cortex, have been successfully implemented for control of brain machine interfaces (BMIs). Optogenetics, direct optical stimulation of neurons in brain tissue genetically modified to express channelrhodopsin-2 (ChR2), enables targeting of specific types of neurons with sub-millisecond temporal precision. In this work, we developed a BMI device, called an Opto- μECoG array, which combines ECoG recording and optogenetics-based stimulation to enable multichannel, bi-directional interactions with neurons. The Opto- μECoG array comprises two sub-arrays, each containing a 4 × 4 distribution of micro-epidural transparent electrodes ( ∼ 200 μm diameter) and embedded light-emitting diodes (LEDs) for optical neural stimulation on a 2.5 × 2.5 mm² footprint to match the bilateral hemispherical area of the visual cortex in a rat. The transparent electrodes were fabricated with indium tin oxide (ITO). Parylene-C served as the main structural and packaging material for flexibility and biocompatibility. Optical, electrical, and thermal characteristics of the fabricated device were investigated and in vivo experiments were performed to evaluate the efficacy of the device. PMID:24144668

  14. Efficient Electron Collection in Hybrid Polymer Solar Cells: In-Situ-Generated ZnO/Poly(3-hexylthiophene) Scaffolded by a TiO2 Nanorod Array.

    PubMed

    Liao, Wen-Pin; Wu, Jih-Jen

    2013-06-01

    A nanoarchitectural hybrid polymer solar cell, integrating the ordered and the bulk heterojunction hybrid polymer solar cells, is fabricated by infiltrating the diethylzinc/poly(3-hexylthiophene) (P3HT) solution into the interstices of the TiO2 nanorod (NR) array. An inorganic network composed of tiny ZnO nanocrystals is constructed in the in-situ-generated hybrid within the interstice of the single-crystalline TiO2 NRs. The TiO2 NR array, which possesses a longer electron lifetime and an appropriate electron-transport rate, serves not only as an electron transporter/collector extended from fluorine-doped tin oxide (FTO) electrode to sustain the efficient electron collection but also as a scaffold to hold the sufficient amount of ZnO/P3HT hybrid. The in-situ-generated ZnO/P3HT hybrid layer with superior charge separation efficiency can therefore be thickened in the presence of a TiO2 NR array for increasing the light-harvesting efficiency. A notable efficiency of 2.46% is therefore attained in the TiO2 NR-ZnO/P3HT hybrid solar cell. PMID:26283138

  15. Automated Hybridization of X-ray Absorber Elements-A Path to Large Format Microcalorimeter Arrays

    NASA Technical Reports Server (NTRS)

    Moseley, S.; Kelley, R.; Allen, C.; Kilbourne, C.; Costen, N.; Miller, T.

    2007-01-01

    In the design of microcalorimeters, it is often desirable to produce the X-ray absorber separately from the detector element. In this case, the attachment of the absorber to the detector element with the required thermal and mechanical characteristics is a major challenge. In such arrays, the attachment has been done by hand. This process is not easily extended to the large format arrays required for future X- ray astronomy missions such as the New x-ray Telescope or NeXT. In this paper we present an automated process for attaching absorber tiles to the surface of a large-scale X-ray detector array. The absorbers are attached with stycast epoxy to a thermally isolating polymer structure made of SU-8. SU-8 is a negative epoxy based photo resist produced by Microchem. We describe the fabrication of the X-ray absorbers and their suspension on a handle die in an adhesive matrix. We describe the production process for the polymer isolators on the detector elements. We have developed a new process for the alignment, and simultaneous bonding of the absorber tiles to an entire detector array. This process uses equipment and techniques used in the flip-chip bonding industry and approaches developed in the fabrication of the XRS-2 instrument. XRS-2 was an X-ray spectrometer that was launched on the Suzaku telescope in July 10, 2005. We describe the process and show examples of sample arrays produced by this process. Arrays with up to 300 elements have been bonded. The present tests have used dummy absorbers made of Si. In future work, we will demonstrate bonding of HgTe absorbers.

  16. Array-based comparative genomic hybridization for the detection of DNA sequence copy number changes in Barrett's adenocarcinoma.

    PubMed

    Albrecht, Bettina; Hausmann, Michael; Zitzelsberger, Horst; Stein, Hubert; Siewert, Jörg Rüdiger; Hopt, Ulrich; Langer, Rupert; Höfler, Heinz; Werner, Martin; Walch, Axel

    2004-07-01

    Array-based comparative genomic hybridization (aCGH) allows the identification of DNA sequence copy number changes at high resolution by co-hybridizing differentially labelled test and control DNAs to a micro-array of genomic clones. The present study has analysed a series of 23 formalin-fixed, paraffin wax-embedded tissue samples of Barrett's adenocarcinoma (BCA, n = 18) and non-neoplastic squamous oesophageal (n = 2) and gastric cardia mucosa (n = 3) by aCGH. The micro-arrays used contained 287 genomic targets covering oncogenes, tumour suppressor genes, and DNA sequences localized within chromosomal regions previously reported to be altered in BCA. DNA sequence copy number changes for a panel of approximately 50 genes were identified, most of which have not been previously described in BCA. DNA sequence copy number gains (mean 41 +/- 25/BCA) were more frequent than DNA sequence copy number losses (mean 20 +/- 15/BCA). The highest frequencies for DNA sequence copy number gains were detected for SNRPN (61%); GNLY (44%); NME1 (44%); DDX15, ABCB1 (MDR), ATM, LAMA3, MYBL2, ZNF217, and TNFRSF6B (39% each); and MSH2, TERC, SERPINE1, AFM137XA11, IGF1R, and PTPN1 (33% each). DNA sequence copy number losses were identified for PDGFB (44%); D17S125 (39%); AKT3 (28%); and RASSFI, FHIT, CDKN2A (p16), and SAS (CDK4) (28% each). In all non-neoplastic tissue samples of squamous oesophageal and gastric cardia mucosa, the measured mean ratios were 1.00 (squamous oesophageal mucosa) or 1.01 (gastric mucosa), indicating that no DNA sequence copy number chances were present. For validation, the DNA sequence copy number changes of selected clones (SNRPN, CMYC, HER2, ZNF217) detected by aCGH were confirmed by fluorescence in situ hybridization (FISH). These data show the sensitivity of aCGH for the identification of DNA sequence copy number changes at high resolution in BCA. The newly identified genes may include so far unknown biomarkers in BCA and are therefore a starting point for

  17. Adhesive behaviour of gecko-inspired nanofibrillar arrays: combination of experiments and finite element modelling

    NASA Astrophysics Data System (ADS)

    Wang, Zheng-zhi; Xu, Yun; Gu, Ping

    2012-04-01

    A polypropylene nanofibrillar array was successfully fabricated by template-assisted nanofabrication strategy. Adhesion properties of this gecko-inspired structure were studied through two parallel and independent approaches: experiments and finite element simulations. Experimental results show relatively good normal adhesion, but accompanied by high preloads. The interfacial adhesion was modelled by effective spring elements with piecewise-linear constitution. The effective elasticity of the fibre-array system was originally calculated from our measured elasticity of single nanowire. Comparisons of the experimental and simulative results reveal quantitative agreement except for some explainable deviations, which suggests the potential applicability of the present models and applied theories.

  18. Hybrid core-shell nanowire electrodes utilizing vertically aligned carbon nanofiber arrays for high-performance energy storage

    NASA Astrophysics Data System (ADS)

    Klankowski, Steven Arnold

    Nanostructured electrode materials for electrochemical energy storage systems have been shown to improve both rate performance and capacity retention, while allowing considerably longer cycling lifetime. The nano-architectures provide enhanced kinetics by means of larger surface area, higher porosity, better material interconnectivity, shorter diffusion lengths, and overall mechanical stability. Meanwhile, active materials that once were excluded from use due to bulk property issues are now being examined in new nanoarchitecture. Silicon was such a material, desired for its large lithium-ion storage capacity of 4,200 mAh g-1 and low redox potential of 0.4 V vs. Li/Li+; however, a ˜300% volume expansion and increased resistivity upon lithiation limited its broader applications. In the first study, the silicon-coated vertically aligned carbon nanofiber (VACNF) array presents a unique core-shell nanowire (NW) architecture that demonstrates both good capacity and high rate performance. In follow-up, the Si-VACNFs NW electrode demonstrates enhanced power rate capabilities as it shows excellent storage capacity at high rates, attributed to the unique nanoneedle structure that high vacuum sputtering produces on the three-dimensional array. Following silicon's success, titanium dioxide has been explored as an alternative high-rate electrode material by utilizing the dual storage mechanisms of Li+ insertion and pseudocapacitance. The TiO 2-coated VACNFs shows improved electrochemical activity that delivers near theoretical capacity at larger currents due to shorter Li+ diffusion lengths and highly effective electron transport. A unique cell is formed with the Si-coated and TiO2-coated electrodes place counter to one another, creating the hybrid of lithium ion battery-pseudocapacitor that demonstrated both high power and high energy densities. The hybrid cell operates like a battery at lower current rates, achieving larger discharge capacity, while retaining one-third of

  19. Application of a silicon photodiode array for solar edge tracking in the Halogen Occultation Experiment

    NASA Technical Reports Server (NTRS)

    Mauldin, L. E., III; Moore, A. S.; Stump, C. S.; Mayo, L. S.

    1985-01-01

    The optical and electronic design of the Halogen Occultation Experiment (HALOE) elevation sunsensor is described. This system uses a Galilean telescope to form a solar image on a linear silicon photodiode array. The array is a self-scanned, monolithic charge coupled device. The addresses of both solar edges imaged on the array are used by the control/pointing system to scan the HALOE science instantaneous-field-of-view (IFOV) across the vertical solar diameter during instrument calibration, and then maintain the science IFOV four arcmin below the top edge during the science data occultation event. Vertical resolution of 16 arcsec and a radiometric dynamic range of 100 are achieved at the 0.7 micrometer operating wavelength. The design provides for loss of individual photodiode elements without loss of angular tracking capability. The HALOE instrument is a gas correlation radiometer that is now being developed by NASA Langley Research Center for the Upper Atmospheric Research Satellite.

  20. Copy number analysis of the low-copy repeats at the primate NPHP1 locus by array comparative genomic hybridization.

    PubMed

    Yuan, Bo; Liu, Pengfei; Rogers, Jeffrey; Lupski, James R

    2016-06-01

    Array comparative genomic hybridization (aCGH) has been widely used to detect copy number variants (CNVs) in both research and clinical settings. A customizable aCGH platform may greatly facilitate copy number analyses in genomic regions with higher-order complexity, such as low-copy repeats (LCRs). Here we present the aCGH analyses focusing on the 45 kb LCRs [1] at the NPHP1 region with diverse copy numbers in humans. Also, the interspecies aCGH analysis comparing human and nonhuman primates revealed dynamic copy number transitions of the human 45 kb LCR orthologues during primate evolution and therefore shed light on the origin of complexity at this locus. The original aCGH data are available at GEO under GSE73962. PMID:27222811

  1. Investigation of hybrid pixel detector arrays by synchrotron-radiation imaging

    NASA Astrophysics Data System (ADS)

    Helfen, L.; Myagotin, A.; Pernot, P.; DiMichiel, M.; Mikulík, P.; Berthold, A.; Baumbach, T.

    2006-07-01

    Synchrotron-radiation imaging was applied to the non-destructive testing of detector devices during their development cycle. Transmission imaging known as computed laminography was used to examine the microstructure of the interconnections in order to investigate the perfection of technological steps necessary for hybrid detector production. A characterisation of the solder bump microstructure can reveal production flaws such as missing or misaligned bumps, voids in bumps or bridges and thus give valuable information about the bonding process.

  2. Total x-ray power improvement on recent wire array experiments on the Z machine.

    SciTech Connect

    Jennings, Christopher A.; Ampleford, David J.; Porter, John Larry, Jr.; Cuneo, Michael Edward; Savage, Mark Edward; Rochau, Gregory Alan; Lopez, Mike R.; Jones, Brent Manley; Jones, Michael C.

    2010-11-01

    Recent experiments on the refurbished Z-machine were conducted using large diameter stainless steel arrays which produced x-ray powers of 260 TW. Follow-up experiments were then conducted utilizing tungsten wires with approximately the same total mass with the hypothesis that the total x-ray power would increase. On the large diameter tungsten experiments, the x-ray power averaged over 300 TW and the total x-ray energy was greater than 2MJ. Different analysis techniques for inferring the x-ray power will be described in detail.

  3. A genome-wide analysis of array-based comparative genomic hybridization (CGH) data to detect intra-species variations and evolutionary relationships.

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Array-based comparative genomics hybridization (CGH) has gained prevalence as a technique of choice for the detection of structural variations in the genome. In this study, we propose a novel genome-wide method of classification using CGH data, in order to reveal putative phylogenetic relationships ...

  4. The Auger Engineering Radio Array and multi-hybrid cosmic ray detection

    NASA Astrophysics Data System (ADS)

    Holt, E. M.; Pierre Auger Collaboration

    2016-05-01

    The Auger Engineering Radio Array (AERA) aims at the detection of air showers induced by high-energy cosmic rays. As an extension of the Pierre Auger Observatory, it measures complementary information to the particle detectors, fluorescence telescopes and to the muon scintillators of the Auger Muons and Infill for the Ground Array (AMIGA). AERA is sensitive to all fundamental parameters of an extensive air shower such as the arrival direction, energy and depth of shower maximum. Since the radio emission is induced purely by the electromagnetic component of the shower, in combination with the AMIGA muon counters, AERA is perfect for separate measurements of the electrons and muons in the shower, if combined with a muon counting detector like AMIGA. In addition to the depth of the shower maximum, the ratio of the electron and muon number serves as a measure of the primary particle mass.

  5. Gate tunability and collapse of superconductivity in hybrid tin-graphene Josephson junction arrays

    NASA Astrophysics Data System (ADS)

    Bouchiat, Vincent

    The accessible and surface-exposed 2D electron gas offered by graphene provides indeed an ideal platform on which to tune, via application of an electrostatic gate, the coupling between adsorbates deposited on its surface. We have experimentally studied the case of graphene transistors which channel is decorated with an array of superconducting tin nanoparticles. They induce via percolation of proximity effect a global 2D superconducting state which critical temperature Tc can be tuned by gate voltage. When the Graphene show strong disorder, it is possible to tune via the applied gate voltage the system towards an insulating state, demonstrating the possibility to trigger a superconducting to insulator transition, which features ressembles those found in granular superconductors. In this work, graphene monolayers are surface-conjugated to regular arrays of superconducting disk-shaped metal islands, whose inter-island distances were patterned to be in the quasi-ballistic limit of the underlying 2D electron gas. Arrays can be made on a large range of geometry and density, up to the highly diluted limit with less than 5% surface coverage and few micrometers in between islands. In the lower temperature limit (<100 mK) , despite of the long distance (2 microns) in between islands, a supercurrent was observed among the whole graphene sheet. Interestingly, the superconducting state vanishes exponentially in gate voltage and rests in a metallic state, caused by quantum fluctuations of phase is found for diluted and regular arrays. This peculiar behaviour provides evidence for recently developed theory, and may provide a hint to the understanding of long-standing issue of ``zero-temperature'' bosonic metallic state

  6. Design and fabrication of polarization-insensitive hybrid solgel arrayed waveguide gratings.

    PubMed

    Park, Soon-Ryong; Jeong, Jaewan; O, Beom-Hoan; Lee, Seung-Gol; Lee, El-Hang

    2003-03-15

    We report on the successful design and fabrication of a polarization-insensitive arrayed waveguide grating (AWG), using solgel-derived silica glass films formed on fused-silica substrates. By controlling the waveguide width and making the propagation constants of the polarizations equal, we have found it possible to fabricate polarization-insensitive solgel-based AWGs. Polarization-insensitive design improves the cross talk by approximately 10 dB in the dynamic range. PMID:12659253

  7. Tunable polymer brush/Au NPs hybrid plasmonic arrays based on host-guest interaction.

    PubMed

    Fang, Liping; Li, Yunfeng; Chen, Zhaolai; Liu, Wendong; Zhang, Junhu; Xiang, Siyuan; Shen, Huaizhong; Li, Zibo; Yang, Bai

    2014-11-26

    The fabrication of versatile gold nanoparticle (Au NP) arrays with tunable optical properties by a novel host-guest interaction are presented. The gold nanoparticles were incorporated into polymer brushes by host-guest interaction between β-cyclodextrin (β-CD) ligand of gold nanoparticles and dimethylamino group of poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA). The gold nanoparticle arrays were prepared through the template of PDMAEMA brush patterns which were fabricated combining colloidal lithography and surface-initiated atom-transfer radical polymerization (SI-ATRP). The structure parameters of gold nanoparticle patterns mediated by polymer brushes such as height, diameters, periods and distances, could be easily tuned by tailoring the etching time or size of colloidal spheres in the process of colloidal lithography. The change of optical properties induced by different gold nanoparticle structures was demonstrated. The direct utilization of PDMAEMA brushes as guest avoids a series of complicated modification process and the PDMAEMA brushes can be grafted on various substrates, which broaden its applications. The prepared gold naoparticle arrays are promising in applications of nanosensors, memory storage and surface enhanced spectroscopy. PMID:25347749

  8. Strongly coupled metal oxide nanorod arrays with graphene nanoribbons and nanosheets enable novel solid-state hybrid cells

    NASA Astrophysics Data System (ADS)

    Xiao, Junwu; Xi, Jiangbo; Xu, Yangyang; Yang, Shihe; Jin, Yunxia; Xiao, Fei; Wang, Shuai

    2015-06-01

    Electrochemical capacitors and rechargeable batteries are still limited in applications by the low energy and power densities they can deliver, respectively, holding back their deployment in electric vehicles. Here we develop a type of solid-state hybrid cells (SHCs) composed of graphene nanoribbons and nanosheets-coated metal oxide nanorod arrays ((MOx/GNR)@GNS). GNR and GNS are deposited on the surface of MOx nanorod arrays to improve the electron transport characteristic, and thus enhance the energy storage performance. The (MOx/GNR)@GNS-based SHCs can achieve a maximum volumetric energy density of 0.9 mWh cm-3, and still retain 0.4 mWh cm-3 even at 0.1 W cm-3. The energy storage performance is much better than the electrochemical capacitors reported previously, and can even rival the commercial Li thin-film battery but with a significantly higher power density, lower cost and higher safety. Also demonstrated is the good long-term cycle life with only ∼17% loss after 2500 cycles. These salient features make the (MOx/GNR)@GNS composites-based SHCs a strong contender for electrochemical energy storage.

  9. A nanoelectronic nose: a hybrid nanowire/carbon nanotube sensor array with integrated micromachined hotplates for sensitive gas discrimination.

    PubMed

    Chen, Po-Chiang; Ishikawa, Fumiaki N; Chang, Hsiao-Kang; Ryu, Koungmin; Zhou, Chongwu

    2009-03-25

    A novel hybrid chemical sensor array composed of individual In(2)O(3) nanowires, SnO(2) nanowires, ZnO nanowires, and single-walled carbon nanotubes with integrated micromachined hotplates for sensitive gas discrimination was demonstrated. Key features of our approach include the integration of nanowire and carbon nanotube sensors, precise control of the sensor temperature using the micromachined hotplates, and the use of principal component analysis for pattern recognition. This sensor array was exposed to important industrial gases such as hydrogen, ethanol and nitrogen dioxide at different concentrations and sensing temperatures, and an excellent selectivity was obtained to build up an interesting 'smell-print' library of these gases. Principal component analysis of the sensing results showed great discrimination of those three tested chemicals, and in-depth analysis revealed clear improvement of selectivity by the integration of carbon nanotube sensors. This nanoelectronic nose approach has great potential for detecting and discriminating between a wide variety of gases, including explosive ones and nerve agents. PMID:19420469

  10. A nanoelectronic nose: a hybrid nanowire/carbon nanotube sensor array with integrated micromachined hotplates for sensitive gas discrimination

    NASA Astrophysics Data System (ADS)

    Chen, Po-Chiang; Ishikawa, Fumiaki N.; Chang, Hsiao-Kang; Ryu, Koungmin; Zhou, Chongwu

    2009-03-01

    A novel hybrid chemical sensor array composed of individual In2O3 nanowires, SnO2 nanowires, ZnO nanowires, and single-walled carbon nanotubes with integrated micromachined hotplates for sensitive gas discrimination was demonstrated. Key features of our approach include the integration of nanowire and carbon nanotube sensors, precise control of the sensor temperature using the micromachined hotplates, and the use of principal component analysis for pattern recognition. This sensor array was exposed to important industrial gases such as hydrogen, ethanol and nitrogen dioxide at different concentrations and sensing temperatures, and an excellent selectivity was obtained to build up an interesting 'smell-print' library of these gases. Principal component analysis of the sensing results showed great discrimination of those three tested chemicals, and in-depth analysis revealed clear improvement of selectivity by the integration of carbon nanotube sensors. This nanoelectronic nose approach has great potential for detecting and discriminating between a wide variety of gases, including explosive ones and nerve agents.

  11. Device architecture engineering in polymer/ZnO quantum dots/ZnO array ternary hybrid solar cells

    NASA Astrophysics Data System (ADS)

    Wu, Fan; Zhao, Yu; Zhang, Hui; Tong, Yanhua

    2015-09-01

    Hybrid solar cells (HSCs) based on pristine ZnO nanorod array (ZnO-NRA) and conjugated polymer with ordinary inverted device architecture normally perform low open-circuit voltage ( V oc) and short-circuit current density ( J sc). This paper compares three improved device architectures for preparation of efficient polymer/ZnO-NRA HSCs by incorporating ZnO quantum dots (ZnO-QDs) into device with different engineering. It is found that when growth of ZnO-QDs on ZnO nanorod surface to formation of homostructured ZnO core-shell array (ZnO-CSA) instead of pristine ZnO-NRA can significantly increase the device V oc, while blending ZnO-QDs into MEH-PPV between nanorods can significantly increase the device J sc. The best photovoltaic performance is realized in the architecture consisting of ZnO-CSA as well as blends of MEH-PPV and ZnO-QDs, in which the V oc and J sc can be significant enhanced simultaneously. The present study reports the architecture-related device performances in polymer/ZnO-NRA solar cells, which will help to guide the design of HSCs or related optoelectronic devices.

  12. Spacecraft Hybrid (Mixed-Actuator) Attitude Control Experiences on NASA Science Missions

    NASA Technical Reports Server (NTRS)

    Dennehy, Cornelius J.

    2014-01-01

    There is a heightened interest within NASA for the design, development, and flight implementation of mixed-actuator hybrid attitude control systems for science spacecraft that have less than three functional reaction wheel actuators. This interest is driven by a number of recent reaction wheel failures on aging, but what could be still scientifically productive, NASA spacecraft if a successful hybrid attitude control mode can be implemented. Over the years, hybrid (mixed-actuator) control has been employed for contingency attitude control purposes on several NASA science mission spacecraft. This paper provides a historical perspective of NASA's previous engineering work on spacecraft mixed-actuator hybrid control approaches. An update of the current situation will also be provided emphasizing why NASA is now so interested in hybrid control. The results of the NASA Spacecraft Hybrid Attitude Control Workshop, held in April of 2013, will be highlighted. In particular, the lessons learned captured from that workshop will be shared in this paper. An update on the most recent experiences with hybrid control on the Kepler spacecraft will also be provided. This paper will close with some future considerations for hybrid spacecraft control.

  13. Automated UF6 Cylinder Enrichment Assay: Status of the Hybrid Enrichment Verification Array (HEVA) Project: POTAS Phase II

    SciTech Connect

    Jordan, David V.; Orton, Christopher R.; Mace, Emily K.; McDonald, Benjamin S.; Kulisek, Jonathan A.; Smith, Leon E.

    2012-06-01

    Pacific Northwest National Laboratory (PNNL) intends to automate the UF6 cylinder nondestructive assay (NDA) verification currently performed by the International Atomic Energy Agency (IAEA) at enrichment plants. PNNL is proposing the installation of a portal monitor at a key measurement point to positively identify each cylinder, measure its mass and enrichment, store the data along with operator inputs in a secure database, and maintain continuity of knowledge on measured cylinders until inspector arrival. This report summarizes the status of the research and development of an enrichment assay methodology supporting the cylinder verification concept. The enrichment assay approach exploits a hybrid of two passively-detected ionizing-radiation signatures: the traditional enrichment meter signature (186-keV photon peak area) and a non-traditional signature, manifested in the high-energy (3 to 8 MeV) gamma-ray continuum, generated by neutron emission from UF6. PNNL has designed, fabricated, and field-tested several prototype assay sensor packages in an effort to demonstrate proof-of-principle for the hybrid assay approach, quantify the expected assay precision for various categories of cylinder contents, and assess the potential for unsupervised deployment of the technology in a portal-monitor form factor. We refer to recent sensor-package prototypes as the Hybrid Enrichment Verification Array (HEVA). The report provides an overview of the assay signatures and summarizes the results of several HEVA field measurement campaigns on populations of Type 30B UF6 cylinders containing low-enriched uranium (LEU), natural uranium (NU), and depleted uranium (DU). Approaches to performance optimization of the assay technique via radiation transport modeling are briefly described, as are spectroscopic and data-analysis algorithms.

  14. Criticality experiments with mixed oxide fuel pin arrays in plutonium-uranium nitrate solution

    SciTech Connect

    Lloyd, R.C. ); Smolen, G.R. )

    1988-08-01

    A series of critical experiments was completed with mixed plutonium-uranium solutions having a Pu/(Pu + U) ratio of approximately 0.22 in a boiler tube-type lattice assembly. These experiments were conducted as part of the Criticality Data Development Program between the United States Department of Energy (USDOE) and the Power Reactor and Nuclear Fuel Development Corporation (PNC) of Japan. A complete description of the experiments and data are included in this report. The experiments were performed with an array of mixed oxide fuel pins in aqueous plutonium-uranium solutions. The fuel pins were contained in a boiler tube-type tank and arranged in a 1.4 cm square pitch array which resembled cylindrical geometry. One experiment was perfomed with the fuel pins removed from the vessel. The experiments were performed with a water reflector. The concentration of the solutions in the boiler tube-type tank was varied from 4 to 468 g (Pu + U)/liter. The ratio of plutonium to total heavy metal (plutonium plus uranium) was approximately 0.22 for all experiments.

  15. Three-dimensional TiO2/ZnO hybrid array as a heterostructured anode for efficient quantum-dot-sensitized solar cells.

    PubMed

    Feng, Hao-Lin; Wu, Wu-Qiang; Rao, Hua-Shang; Wan, Quan; Li, Long-Bin; Kuang, Dai-Bin; Su, Cheng-Yong

    2015-03-11

    The development of a novel nanoarray photoanode with a heterostructure on a transparent conducting oxide substrate provides a promising scheme to fabricate efficient energy conversion devices. Herein, we successfully synthesize the vertically aligned hierarchical TiO2 nanowire/ZnO nanorod or TiO2 nanowire/ZnO nanosheet hybrid arrays, which are proven to be excellent anode candidates for superior light utilization. Consequently, the quantum-dot-sensitized solar cells based on such hybrid arrays exhibit an impressive power conversion efficiency (PCE) under AM 1.5G one sun illumination with improved short-circuit current density (JSC) and fill factor compared to pristine TiO2 nanowire arrays. Combined with the chemical-bath-deposited Cu2S counter electrode, the eventual PCE can be further optimized to as high as 4.57% for CdS/CdSe co-sensitized quantum dot solar cells. PMID:25679232

  16. Flight Experience from Space Photovoltaic Concentrator Arrays and its Implication on Terrestrial Concentrator Systems

    NASA Technical Reports Server (NTRS)

    Piszczor, Michael F., Jr.

    2003-01-01

    Nearly all photovoltaic solar arrays flown in space have used a planar (non- concentrating) design. However, there have been a few notable exceptions where photovoltaic concentrators have been tested and used as the mission s primary power source. Among these are the success experienced by the SCARLET (Solar Concentrator Array with Refractive Linear Element Technology) concept used to power NASA's Deep Space 1 mission and the problems encountered by the original Boeing 702 reflective trough concentrator design. This presentation will give a brief overview of past photovoltaic concentrator systems that have flown in space, specifically addressing the valuable lessons learned from flight experience, and other viable concentrator concepts that are being proposed for the future. The general trends of this flight experience will be noted and discussed with regard to its implications on terrestrial photovoltaic concentrator designs.

  17. The STEP/STACBEAM experiment technology development for very large solar array deployers

    NASA Technical Reports Server (NTRS)

    Samuels, R.

    1984-01-01

    The Stacking Triangular Articulated Compact Beam (STACBEAM) is discussed with reference to structural testing experiments afforded by ground simulation and the Space Technology Experiments Platform (STEP). The STACBEAM lends itself to a deployment technique which offers a radical improvement in flexible blanket solar array technology. A system for deployment and support of a solar array blanket is described which consists of the blanket, its containment structure, the support structure and its deployer, the blanket stiffening battens, and the deployable boom standoffs. In operation, the blanket is pulled out and supported by the STACBEAM which packages next to the folded blanket. Since the STACBEAM does not rotate during extension, complete control of the blanket is maintained during extension. Deployment of this system occurs one bay at a time in a sequential manner. The deployer provides sufficient rigidity so that beam stiffness is not degraded during the deployment process.

  18. The calibration system for the photomultiplier array of the SNO+ experiment

    NASA Astrophysics Data System (ADS)

    Alves, R.; Andringa, S.; Bradbury, S.; Carvalho, J.; Chauhan, D.; Clark, K.; Coulter, I.; Descamps, F.; Falk, E.; Gurriana, L.; Kraus, C.; Lefeuvre, G.; Maio, A.; Maneira, J.; Mottram, M.; Peeters, S.; Rose, J.; Seabra, L.; Sinclair, J.; Skensved, P.; Waterfield, J.; White, R.; Wilson, J. R.

    2015-03-01

    A light injection system using LEDs and optical fibres was designed for the calibration and monitoring of the photomultiplier array of the SNO+ experiment at SNOLAB. Large volume, non-segmented, low-background detectors for rare event physics, such as the multi-purpose SNO+ experiment, need a calibration system that allow an accurate and regular measurement of the performance parameters of their photomultiplier arrays, while minimising the risk of radioactivity ingress. The design implemented for SNO+ uses a set of optical fibres to inject light pulses from external LEDs into the detector. The design, fabrication and installation of this light injection system, as well as the first commissioning tests, are described in this paper. Monte Carlo simulations were compared with the commissioning test results, confirming that the system meets the performance requirements.

  19. Experimental characterization, evaluation, and diagnosis of advanced hybrid infrared focal plane array electro-optical performance

    NASA Astrophysics Data System (ADS)

    Lomheim, Terrence S.; Schumann, Lee W.; Kohn, Stanley E.

    1998-07-01

    High performance scanning time-delay-and-integration and staring hybrid focal plane devices with very large formats, small pixel sizes, formidable frame and line rates, on-chip digital programmability, and high dynamic ranges, are being developed for a myriad of defense, civil, and commercial applications that span the spectral range from shortwave infrared (SWIR) to longwave infrared (LWIR). An essential part in the development of such new advanced hybrid infrared focal planes is empirical validation of their electro-optical (EO) performance. Many high-reliability, high-performance applications demand stringent and near flawless EO performance over a wide variety of operating conditions and environments. Verification of focal plane performance compliance over this wide range of parametric conditions requires the development and use of accurate, flexible, and statistically complete test methods and associated equipment. In this paper we review typical focal plane requirements, the ensuing measurement requirements (quantity, accuracy, repeatability, etc.), test methodologies, test equipment requirements, electronics and computer-based data acquisition requirements, statistical data analysis and display requirements, and associated issues. We also discuss special test requirements for verifying the performance of panchromatic thermal and multispectral imaging focal planes where characterization of dynamic modulation transfer function (MTF), and point-image response and optical overload is generally required. We briefly overview focal plane radiation testing. We conclude with a discussion of the technical challenges of characterizing future advanced hybrid focal plane testing where it is anticipated that analog-to- digital conversion will be included directly on focal plane devices, thus creating the scenario of 'photons-in-to-bits- out' within the focal plane itself.

  20. High-resolution detection of recurrent aberrations in lung adenocarcinomas by array comparative genomic hybridization and expression analysis of selective genes by quantitative PCR.

    PubMed

    Zhu, Hong; Wong, Maria Pik; Tin, Vicky

    2014-06-01

    Genomic abnormalities are the hallmark of cancers and may harbor potential candidate genes important for cancer development and progression. We performed array comparative genomic hybridization (array CGH) on 36 cases of primary lung adenocarcinoma (AD) using an array containing 2621 BAC or PAC clones spanning the genome at an average interval of 1 Mb. Array CGH identified the commonest aberrations consisting of DNA gains within 1p, 1q, 5p, 5q, 7p, 7q, 8q, 11q, 12p, 13q, 16p, 17q, 20q, and losses with 6q, 9p, 10q and 18q. High-level copy gains involved mainly 7p21-p15 and 20q13.3. Dual color fluorescence in situ hybridization (FISH) was performed on a selective locus for validation of array CGH results. Genomic aberrations were compared with different clinicopathological features and a trend of higher number of aberrations in tumors with aggressive phenotypes and current tobacco exposure was identified. According to array CGH data, 23 candidate genes were selected for quantitative PCR (qPCR) analysis. The concordance observed between the genomic and expression changes in most of the genes suggested that they could be candidate cancer-related genes that contributed to the development of lung AD. PMID:24728343

  1. Bilayer hybrid nanoimprinting method for fabricating embedded silver nanostructure arrays with enhanced photoluminescence

    NASA Astrophysics Data System (ADS)

    Choi, Jun-Hyuk; Sung, Sang-Keun; Kim, Chul-Hyun; Jung, Yeon-Ho; Jung, Joo-Yun; Jeong, Jun-Ho; Lee, Eung-Sug

    2014-01-01

    A bilayer hybrid nanoimprinting (NI) method was developed for fabricating embedded metal nanopatterns with greater processability and improved reliability for enhanced photoluminescence (PL) in optoelectronic devices. Bilayer hybrid NI consists of the following: (a) spin-coating ultraviolet (UV) and thermally curable NI resists in sequence, (b) high-pressure thermal NI and UV exposure while maintaining the stamp in a pressed position, and (c) silver (Ag) deposition and lift-off using a thermal NI resist on the upper surface to create embedded Ag nanoarrays. Reference samples with no Ag nanopatterns and with protruding Ag dot-shaped nanopatterns were also fabricated for comparison. The transmittance and PL of all samples were measured. All samples containing Ag nanopatterns exhibited improved PL compared with reference samples with no Ag. For all pattern sizes, the samples with the embedded Ag nanoarrays exhibited the highest PL; the relative PL enhancements compared with samples with Ag dot-shaped nanoarrays were 32.2%, 36.1%, and 62.7% for pattern sizes of 150, 200, and 265 nm, respectively.

  2. Revisiting Milgram's Cyranoid Method: Experimenting With Hybrid Human Agents.

    PubMed

    Corti, Kevin; Gillespie, Alex

    2015-01-01

    In two studies based on Stanley Milgram's original pilots, we present the first systematic examination of cyranoids as social psychological research tools. A cyranoid is created by cooperatively joining in real-time the body of one person with speech generated by another via covert speech shadowing. The resulting hybrid persona can subsequently interact with third parties face-to-face. We show that naïve interlocutors perceive a cyranoid to be a unified, autonomously communicating person, evidence for a phenomenon Milgram termed the "cyranic illusion." We also show that creating cyranoids composed of contrasting identities (a child speaking adult-generated words and vice versa) can be used to study how stereotyping and person perception are mediated by inner (dispositional) vs. outer (physical) identity. Our results establish the cyranoid method as a unique means of obtaining experimental control over inner and outer identities within social interactions rich in mundane realism. PMID:25185802

  3. The Milano-Gran Sasso double beta decay experiment: toward a 20-crystal array

    NASA Astrophysics Data System (ADS)

    Alessandrello, A.; Brofferio, C.; Bucci, C.; Camin, D. V.; Cremonesi, O.; Fiorini, E.; Giuliani, A.; Nucciotti, A.; Pavan, M.; Pessina, G.; Previtali, E.; Zanotti, L.

    1996-02-01

    TeO 2 thermal detectors are being used by the Milano group to search for neutrinoless double beta decay of 130Te. An upper limit for neutrinoless decay half life of 2.1 × 10 22 yr at 90% CL obtained with a 334 g TeO 2 detector has been previously reported. To improve the sensitivity of the experiment an array of twenty 340 g TeO 2 crystals will be realised in the next future. As a first step toward the realisation of that experiment a 4 crystal detector has been tested in the Gran Sasso refrigerator. Detector performances, data acquisition and analysis are discussed.

  4. Iontophoresis and Flame Photometry: A Hybrid Interdisciplinary Experiment

    ERIC Educational Resources Information Center

    Sharp, Duncan; Cottam, Linzi; Bradley, Sarah; Brannigan, Jeanie; Davis, James

    2010-01-01

    The combination of reverse iontophoresis and flame photometry provides an engaging analytical experiment that gives first-year undergraduate students a flavor of modern drug delivery and analyte extraction techniques while reinforcing core analytical concepts. The experiment provides a highly visual demonstration of the iontophoresis technique and…

  5. Lower-hybrid-heating experiments on the Alcator C and the Versator II tokamaks

    SciTech Connect

    ,; Takase, Y.

    1982-01-01

    Initial results are reported from lower hybrid wave heating experiments carried out on the MIT Alcator C and Versator II tokamaks. In the Alcator C experiments a 4 waveguide array, with internally brazed ceramic windows has been used to inject 160 kW of microwave power at 4.6 GHz into the plasma with n/sub 0/ less than or equal to 1 x 10/sup 15/ cm/sup -3/, and B/sub 0/ less than or equal to 12 T. An RF power density of 8 kW/cm/sup 2/ has been transmitted into the plasma without RF breakdown. RF coupling studies show optimal coupling (R less than or equal to 10%) when the local density at the waveguide mouth is 25 to 50 times overdense. Initial heating experiments show an ion tail formation in hydrogen discharge peaking at a density of anti n approx. = 2.7 x 10/sup 14/ cm/sup -3/ at B = 8.9 T, and bulk ion heating at a density of anti n approx. = 1.5 x 10/sup 14/ c/sup -3/ at B approx. = 11 T. Evidence of RF current enhancement has been observed at a density of n approx. = 3 x 10/sup 13/ cm/sup -3/. In the Versator II tokamak initial ion heating studies have been carried out using an 800 MHz, 140 kW klystron. With 50 kW of net RF power injected through a 4 waveguide grill at B = 1.3 T and anti n = 2.5 x 10/sup 13/ cm/sup -3/, Doppler broadening of the OVII and NVI lines shows a ..delta..T/sub i/ = 50 eV rise in the bulk ion temperature. A significant RF produced ion tail is also observed by charge exchange analysis. We have succeeded in combining a toroidal ray-tracing code and a 1-D transport code to study the heating density bands and heating efficiencies.

  6. Analysis of oligonucleotide array experiments with repeated measures using mixed models

    PubMed Central

    Li, Hao; Wood, Constance L; Getchell, Thomas V; Getchell, Marilyn L; Stromberg, Arnold J

    2004-01-01

    Background Two or more factor mixed factorial experiments are becoming increasingly common in microarray data analysis. In this case study, the two factors are presence (Patients with Alzheimer's disease) or absence (Control) of the disease, and brain regions including olfactory bulb (OB) or cerebellum (CER). In the design considered in this manuscript, OB and CER are repeated measurements from the same subject and, hence, are correlated. It is critical to identify sources of variability in the analysis of oligonucleotide array experiments with repeated measures and correlations among data points have to be considered. In addition, multiple testing problems are more complicated in experiments with multi-level treatments or treatment combinations. Results In this study we adopted a linear mixed model to analyze oligonucleotide array experiments with repeated measures. We first construct a generalized F test to select differentially expressed genes. The Benjamini and Hochberg (BH) procedure of controlling false discovery rate (FDR) at 5% was applied to the P values of the generalized F test. For those genes with significant generalized F test, we then categorize them based on whether the interaction terms were significant or not at the α-level (αnew = 0.0033) determined by the FDR procedure. Since simple effects may be examined for the genes with significant interaction effect, we adopt the protected Fisher's least significant difference test (LSD) procedure at the level of αnew to control the family-wise error rate (FWER) for each gene examined. Conclusions A linear mixed model is appropriate for analysis of oligonucleotide array experiments with repeated measures. We constructed a generalized F test to select differentially expressed genes, and then applied a specific sequence of tests to identify factorial effects. This sequence of tests applied was designed to control for gene based FWER. PMID:15626348

  7. 3D carbon/cobalt-nickel mixed-oxide hybrid nanostructured arrays for asymmetric supercapacitors.

    PubMed

    Zhu, Jianhui; Jiang, Jian; Sun, Zhipeng; Luo, Jingshan; Fan, Zhanxi; Huang, Xintang; Zhang, Hua; Yu, Ting

    2014-07-23

    The electrochemical performance of supercapacitors relies not only on the exploitation of high-capacity active materials, but also on the rational design of superior electrode architectures. Herein, a novel supercapacitor electrode comprising 3D hierarchical mixed-oxide nanostructured arrays (NAs) of C/CoNi3 O4 is reported. The network-like C/CoNi3 O4 NAs exhibit a relatively high specific surface area; it is fabricated from ultra-robust Co-Ni hydroxide carbonate precursors through glucose-coating and calcination processes. Thanks to their interconnected three-dimensionally arrayed architecture and mesoporous nature, the C/CoNi3 O4 NA electrode exhibits a large specific capacitance of 1299 F/g and a superior rate performance, demonstrating 78% capacity retention even when the discharge current jumps by 100 times. An optimized asymmetric supercapacitor with the C/CoNi3 O4 NAs as the positive electrode is fabricated. This asymmetric supercapacitor can reversibly cycle at a high potential of 1.8 V, showing excellent cycling durability and also enabling a remarkable power density of ∼13 kW/kg with a high energy density of ∼19.2 W·h/kg. Two such supercapacitors linked in series can simultaneously power four distinct light-emitting diode indicators; they can also drive the motor of remote-controlled model planes. This work not only presents the potential of C/CoNi3 O4 NAs in thin-film supercapacitor applications, but it also demonstrates the superiority of electrodes with such a 3D hierarchical architecture. PMID:24643977

  8. Report: Optimization study of the preparation factors for argan oil microcapsule based on hybrid-level orthogonal array design via SPSS modeling.

    PubMed

    Zhao, Xi; Wu, Xiaoli; Zhou, Hui; Jiang, Tao; Chen, Chun; Liu, Mingshi; Jin, Yuanbao; Yang, Dongsheng

    2014-11-01

    To optimize the preparation factors for argan oil microcapsule using complex coacervation of chitosan cross-linked with gelatin based on hybrid-level orthogonal array design via SPSS modeling. Eight relatively significant factors were firstly investigated and selected as calculative factors for the orthogonal array design from the total of ten factors effecting the preparation of argan oil microcapsule by utilizing the single factor variable method. The modeling of hybrid-level orthogonal array design was built in these eight factors with the relevant levels (9, 9, 9, 9, 7, 6, 2 and 2 respectively). The preparation factors for argan oil microcapsule were investigated and optimized according to the results of hybrid-level orthogonal array design. The priorities order and relevant optimum levels of preparation factors standard to base on the percentage of microcapsule with the diameter of 30~40 μm via SPSS. Experimental data showed that the optimum factors were controlling the chitosan/gelatin ratio, the systemic concentration and the core/shell ratio at 1:2, 1.5% and 1:7 respectively, presetting complex coacervation pH at 6.4, setting cross-linking time and complex coacervation at 75 min and 30 min, using the glucose-delta lactone as the type of cross-linking agent, and selecting chitosan with the molecular weight of 2000~3000. PMID:25410084

  9. Solid state neutral particle analyzer array on National Spherical Torus Experiment

    SciTech Connect

    Shinohara, K.; Darrow, D.S.; Roquemore, A.L.; Medley, S.S.; Cecil, F.E.

    2004-10-01

    A solid state neutral particle analyzer array has been installed on the National Spherical Torus Experiment (NSTX). The array consists of four chords viewing through a common vacuum flange. The tangency radii of the viewing chords are 60, 90, 100, and 120 cm. They view across the three co-injection neutral beam lines [deuterium, 80 keV (typically) with tangency radii 48.7, 59.2, and 69.4 cm] on NSTX and detect co-going energetic ions. A silicon photodiode was calibrated by using a monoenergetic deuteron beam source. Deuterons with energy above 40 keV can be detected with the present setup. The degradation of the performance was also investigated. Lead shot and epoxy are used for neutron shielding to reduce handling any hazardous heavy metal. This method also enables us to make an arbitrary shape to be fit into the complex flight tube.

  10. Review of world experience and properties of materials for encapsulation of terrestrial photovoltaic arrays

    NASA Technical Reports Server (NTRS)

    Carmichael, D. C.; Gaines, G. B.; Sliemers, F. A.; Kistler, C. W.; Igou, R. D.

    1976-01-01

    Published and unpublished information relating to encapsulation systems and materials properties was collected by searching the literature and appropriate data bases (over 1,300 documents were selected and reviewed) and by personal contacts including site and company visits. A data tabulation summarizing world experience with terrestrial photovoltaic arrays (50 installations) is presented in the report. Based on criteria of properties, processability, availability, and cost, candidate materials were identified which have potential for use in encapsulation systems for arrays with a lifetime of over 20 years high reliability, an efficiency greater than 10 percent, a total price less than $500/kW, and a production capacity of 500,000 kW/yr. The recommended materials (all commercially available) include, depending upon the device design, various borosilicate and soda-lime glasses and numerous polymerics suitable for specific encapsulation system functions.

  11. Simultaneous processing of photographic and accelerator array data from sled impact experiment

    NASA Astrophysics Data System (ADS)

    Ash, M. E.

    1982-12-01

    A Quaternion-Kalman filter model is derived to simultaneously analyze accelerometer array and photographic data from sled impact experiments. Formulas are given for the quaternion representation of rotations, the propagation of dynamical states and their partial derivatives, the observables and their partial derivatives, and the Kalman filter update of the state given the observables. The observables are accelerometer and tachometer velocity data of the sled relative to the track, linear accelerometer array and photographic data of the subject relative to the sled, and ideal angular accelerometer data. The quaternion constraints enter through perfect constraint observations and normalization after a state update. Lateral and fore-aft impact tests are analyzed with FORTRAN IV software written using the formulas of this report.

  12. Mass transport at infinite regular arrays of microband electrodes submitted to natural convection: theory and experiments.

    PubMed

    Pebay, Cécile; Sella, Catherine; Thouin, Laurent; Amatore, Christian

    2013-12-17

    Mass transport at infinite regular arrays of microband electrodes was investigated theoretically and experimentally in unstirred solutions. Even in the absence of forced hydrodynamics, natural convection limits the convection-free domain up to which diffusion layers may expand. Hence, several regimes of mass transport may take place according to the electrode size, gap between electrodes, time scale of the experiment, and amplitude of natural convection. They were identified through simulation by establishing zone diagrams that allowed all relative contributions to mass transport to be delineated. Dynamic and steady-state regimes were compared to those achieved at single microband electrodes. These results were validated experimentally by monitoring the chronoamperometric responses of arrays with different ratios of electrode width to gap distance and by mapping steady-state concentration profiles above their surface through scanning electrochemical microscopy. PMID:24283775

  13. Recurrent chromosomal aberrations in intravenous leiomyomatosis of the uterus: high-resolution array comparative genomic hybridization study.

    PubMed

    Buza, Natalia; Xu, Fang; Wu, Weiqing; Carr, Ryan J; Li, Peining; Hui, Pei

    2014-09-01

    Uterine intravenous leiomyomatosis (IVL) is a distinct smooth muscle neoplasm with a potential of clinical aggressiveness due to its ability to extend into intrauterine and extrauterine vasculature. In this study, chromosomal alterations analyzed by oligonucleotide array comparative genomic hybridization were performed in 9 cases of IVL. The analysis was informative in all cases with multiple copy number losses and/or gains observed in each tumor. The most frequent recurrent loss of 22q12.3-q13.1 was observed in 6 tumors (66.7%), followed by losses of 22q11.23-q13.31, 1p36.13-p33, 2p25.3-p23.3, and 2q24.2-q32.2 and gains of 6p22.2, 2q37.3 and 10q22.2-q22.3, in decreasing order of frequency. Copy number variants were identified at 14q11.2, 15q11.1-q11.2, and 15q26.2. Genes mapping to the regions of loss include CHEK2, EWS, NF2, PDGFB, and MAP3K7IP1 on chromosome 22q, HEI10 on chromosome 14q, and succinate dehydrogenase subunit B, E2F2, ARID1A KPNA6, EIF3S2 , PTCH2, and PIK3R3 on chromosome 1p. Regional losses on chromosomes 22q and 1p and gains on chromosomes 12q showed overlaps with those previously observed in uterine leiomyosarcomas. In addition, presence of multiple chromosomal aberrations implies a higher level of genetic instability. Follow-up polymerase chain reaction (PCR) sequencing analysis of MED12 gene revealed absence of G> A transition at nucleotides c.130 or c.131 in all 9 cases, a frequent mutation found in uterine leiomyoma and its variants. In conclusion, this is the first report of high-resolution, genome-wide investigation of IVL by oligonucleotide array comparative genomic hybridization. The presence of high frequencies of recurrent regional loss involving several chromosomes is an important finding and likely related to the pathogenesis of the disease. PMID:25033729

  14. Spectrum of Cytogenomic Abnormalities Revealed by Array Comparative Genomic Hybridization on Products of Conception Culture Failure and Normal Karyotype Samples.

    PubMed

    Zhou, Qinghua; Wu, Shen-Yin; Amato, Katherine; DiAdamo, Autumn; Li, Peining

    2016-03-20

    Approximately 30% of pregnancies after implantation end up in spontaneous abortions, and 50% of them are caused by chromosomal abnormalities. However, the spectrum of genomic copy number variants (CNVs) in products of conception (POC) and the underlying gene-dosage-sensitive mechanisms causing spontaneous abortions remain largely unknown. In this study, array comparative genomic hybridization (aCGH) analysis was performed as a salvage procedure for 128 POC culture failure (POC-CF) samples and as a supplemental procedure for 106 POC normal karyotype (POC-NK) samples. Chromosomal abnormalities were detected in 10% of POC-CF and pathogenic CNVs were detected in 3.9% of POC-CF and 5.7% of POC-NK samples. Compiled results from this study and relevant case series through a literature review demonstrated an abnormality detection rate (ADR) of 35% for chromosomal abnormalities in POC-CF samples, 3.7% for pathogenic CNVs in POC-CF samples, and 4.6% for pathogenic CNVs in POC-NK samples. Ingenuity Pathway Analysis (IPA) was performed on the genes from pathogenic CNVs found in POC samples. The denoted primary gene networks suggested that apoptosis and cell proliferation pathways are involved in miscarriage. In summary, a similar spectrum of cytogenomic abnormalities was observed in POC culture success and POC-CF samples. A threshold effect correlating the number of dosage-sensitive genes in a chromosome with the observed frequency of autosomal trisomy is proposed. A rationalized approach using firstly fluorescence in situ hybridization (FISH) testing with probes of chromosomes X/Y/18, 13/21, and 15/16/22 for common aneuploidies and polyploidies and secondly aCGH for other cytogenomic abnormalities is recommended for POC-CF samples. PMID:27020032

  15. Al wire array implosion experiments on the inductive storage generator GIT-4

    SciTech Connect

    Baksht, R.B.; Datsko, I.M.; Kim, A.A.; Loginov, S.V.; Labetsky, A.Yu.; Shishlov, A.V.

    1995-12-31

    In High Current Electronics Institute the first successful wire array implosion experiments on the inductive storage generator GIT-4 with a long conductive plasma opening switch were carried out in 1989. Those experiments were aimed at obtaining the radiation with quantum energy below 1 keV. Recently the authors carried out aluminum wire array implosion experiments on the GIT-4 generator varying the value of mr{sub 0}{sup 2} parameter from 2.2 {center_dot} 10{sup {minus}5} to 2.4 {center_dot} 10{sup {minus}4} g {center_dot} cm at different charge voltage and at different values of downstream inductance. The aims were two-fold: (1) to obtain the {eta}-dependence of the K-shell radiation yield and determine the liner parameters which provide a maximum K-shell radiation yield; and (2) to study whether the liner resistance, its inductance and change of its inductance during implosion influence on the POS performance. The results of these experiments are presented.

  16. Hybrid nanostructures of well-organized arrays of colloidal quantum dots and a self-assembled monolayer of gold nanoparticles for enhanced fluorescence.

    PubMed

    Liu, Xiaoying; McBride, Sean P; Jaeger, Heinrich M; Nealey, Paul F

    2016-07-15

    Hybrid nanomaterials comprised of well-organized arrays of colloidal semiconductor quantum dots (QDs) in close proximity to metal nanoparticles (NPs) represent an appealing system for high-performance, spectrum-tunable photon sources with controlled photoluminescence. Experimental realization of such materials requires well-defined QD arrays and precisely controlled QD-metal interspacing. This long-standing challenge is tackled through a strategy that synergistically combines lateral confinement and vertical stacking. Lithographically generated nanoscale patterns with tailored surface chemistry confine the QDs into well-organized arrays with high selectivity through chemical pattern directed assembly, while subsequent coating with a monolayer of close-packed Au NPs introduces the plasmonic component for fluorescence enhancement. The results show uniform fluorescence emission in large-area ordered arrays for the fabricated QD structures and demonstrate five-fold fluorescence amplification for red, yellow, and green QDs in the presence of the Au NP monolayer. Encapsulation of QDs with a silica shell is shown to extend the design space for reliable QD/metal coupling with stronger enhancement of 11 times through the tuning of QD-metal spatial separation. This approach provides new opportunities for designing hybrid nanomaterials with tailored array structures and multiple functionalities for applications such as multiplexed optical coding, color display, and quantum transduction. PMID:27251019

  17. Hybrid nanostructures of well-organized arrays of colloidal quantum dots and a self-assembled monolayer of gold nanoparticles for enhanced fluorescence

    NASA Astrophysics Data System (ADS)

    Liu, Xiaoying; McBride, Sean P.; Jaeger, Heinrich M.; Nealey, Paul F.

    2016-07-01

    Hybrid nanomaterials comprised of well-organized arrays of colloidal semiconductor quantum dots (QDs) in close proximity to metal nanoparticles (NPs) represent an appealing system for high-performance, spectrum-tunable photon sources with controlled photoluminescence. Experimental realization of such materials requires well-defined QD arrays and precisely controlled QD–metal interspacing. This long-standing challenge is tackled through a strategy that synergistically combines lateral confinement and vertical stacking. Lithographically generated nanoscale patterns with tailored surface chemistry confine the QDs into well-organized arrays with high selectivity through chemical pattern directed assembly, while subsequent coating with a monolayer of close-packed Au NPs introduces the plasmonic component for fluorescence enhancement. The results show uniform fluorescence emission in large-area ordered arrays for the fabricated QD structures and demonstrate five-fold fluorescence amplification for red, yellow, and green QDs in the presence of the Au NP monolayer. Encapsulation of QDs with a silica shell is shown to extend the design space for reliable QD/metal coupling with stronger enhancement of 11 times through the tuning of QD–metal spatial separation. This approach provides new opportunities for designing hybrid nanomaterials with tailored array structures and multiple functionalities for applications such as multiplexed optical coding, color display, and quantum transduction.

  18. Identification of Clinically Important Chromosomal Aberrations in Acute Myeloid Leukemia by Array-Based Comparative Genomic Hybridization

    PubMed Central

    Mehrotra, Meenakshi; Luthra, Rajyalakshmi; Ravandi, Farhad; Sargent, Rachel L.; Barkoh, Bedia A; Abraham, Ronald; Mishra, Bal Mukund; Medeiros, L. Jeffrey; Patel, Keyur P.

    2014-01-01

    Array-based comparative genomic hybridization (aCGH) chromosomal analysis facilitates rapid detection of cytogenetic abnormalities previously undetectable by conventional cytogenetics. In this study, we analyze 48 uniformly treated acute myeloid leukemia (AML) patients by 44K aCGH and correlated the findings with clinical outcome. aCGH identified previously undetected aberrations, as small as 5 kb, of currently unknown significance. The 36.7 Mb minimally deleted region on chromosome 5 lies between 5q14.3 to 5q33.3 contains 634 genes and 15 microRNAs whereas loss of chromosome 17 spans 3,194 kb involves 342 genes and 12 microRNAs. Loss of 155 kilobase (kb) region on 5q33.3 (p<0.05) is associated with achievement of complete remission. In contrast, loss of 17p11.2-q11.1 was associated with lower CR rate and poorer overall survival (Kaplan-Meier analysis, p<0.0096). aCGH detected loss of 17p in 12/48 patients as compared to 9/48 by conventional karyotyping. In conclusion, aCGH analysis adds to the prognostic stratification of AML patients. PMID:24446873

  19. Silver nanoprism arrays coupled to functional hybrid films for localized surface plasmon resonance-based detection of aromatic hydrocarbons.

    PubMed

    Brigo, Laura; Michieli, Niccolo; Artiglia, Luca; Scian, Carlo; Rizzi, Gian Andrea; Granozzi, Gaetano; Mattei, Giovanni; Martucci, Alessandro; Brusatin, Giovanna

    2014-05-28

    We report the achievement of sensitive gas detection using periodic silver nanoprisms fabricated by a simple and low-cost lithographic technique. The presence of sharp tips combined with the periodic arrangement of the nanoprisms allowed the excitement of isolated and interacting localized surface plasmon resonances. Specific sensing capabilities with respect to aromatic hydrocarbons were achieved when the metal nanoprism arrays were coupled in the near field with functional hybrid films, providing a real-time, label-free, and reversible methodology. Ultra-high-vacuum temperature-programmed desorption measurements demonstrated an interaction energy between the sensitive film and analytes in the range of 55-71 kJ/mol. The far-field optical properties and the detection sensitivity of the sensors, modeled using a finite element method, were correlated to experimental data from gas sensing tests. An absorbance variation of 1.2% could be observed and associated with a theoretical increase in the functional film refractive index of ∼0.001, as a consequence to the interaction with 30 ppm xylene. The possibility of detecting such a small variation in the refractive index suggests the highly promising sensing capabilities of the presented technique. PMID:24750118

  20. Array comparative genomic hybridization and sequencing of 23 genes in 80 patients with myelofibrosis at chronic or acute phase.

    PubMed

    Brecqueville, Mandy; Rey, Jérôme; Devillier, Raynier; Guille, Arnaud; Gillet, Rémi; Adélaide, José; Gelsi-Boyer, Véronique; Arnoulet, Christine; Chaffanet, Max; Mozziconacci, Marie-Joelle; Vey, Norbert; Birnbaum, Daniel; Murati, Anne

    2014-01-01

    Myelofibrosis is a myeloproliferative neoplasm that occurs de novo (primary myelofibrosis) or results from the progression of polycythemia vera or essential thrombocytemia (hereafter designated as secondary myelofibrosis or post-polycythemia vera/ essential thrombocythemia myelofibrosis). To progress in the understanding of myelofibrosis and to find molecular prognostic markers we studied 104 samples of primary and secondary myelofibrosis at chronic (n=68) and acute phases (n=12) from 80 patients, by using array-comparative genomic hybridization and sequencing of 23 genes (ASXL1, BMI1, CBL, DNMT3A, EZH2, IDH1/2, JAK2, K/NRAS, LNK, MPL, NF1, PPP1R16B, PTPN11, RCOR1, SF3B1, SOCS2, SRSF2, SUZ12, TET2, TP53, TRPS1). We found copy number aberrations in 54% of samples, often involving genes with a known or potential role in leukemogenesis. We show that cases carrying a del(20q), del(17) or del(12p) evolve in acute myeloid leukemia (P=0.03). We found that 88% of the cases were mutated, mainly in signaling pathway (JAK2 69%, NF1 6%) and epigenetic genes (ASXL1 26%, TET2 14%, EZH2 8%). Overall survival was poor in patients with more than one mutation (P=0.001) and in patients with JAK2/ASXL1 mutations (P=0.02). Our study highlights the heterogeneity of myelofibrosis, and points to several interesting copy number aberrations and genes with diagnostic and prognostic impact. PMID:23996481

  1. Candidate metastasis suppressor genes uncovered by array comparative genomic hybridization in a mouse allograft model of prostate cancer

    PubMed Central

    Yi, Yajun; Nandana, Srinivas; Case, Thomas; Nelson, Colleen; Radmilovic, Tatjana; Matusik, Robert J; Tsuchiya, Karen D

    2009-01-01

    Background The purpose of this study was to identify candidate metastasis suppressor genes from a mouse allograft model of prostate cancer (NE-10). This allograft model originally developed metastases by twelve weeks after implantation in male athymic nude mice, but lost the ability to metastasize after a number of in vivo passages. We performed high resolution array comparative genomic hybridization on the metastasizing and non-metastasizing allografts to identify chromosome imbalances that differed between the two groups of tumors. Results This analysis uncovered a deletion on chromosome 2 that differed between the metastasizing and non-metastasizing tumors. Bioinformatics filters were employed to mine this region of the genome for candidate metastasis suppressor genes. Of the 146 known genes that reside within the region of interest on mouse chromosome 2, four candidate metastasis suppressor genes (Slc27a2, Mall, Snrpb, and Rassf2) were identified. Quantitative expression analysis confirmed decreased expression of these genes in the metastasizing compared to non-metastasizing tumors. Conclusion This study presents combined genomics and bioinformatics approaches for identifying potential metastasis suppressor genes. The genes identified here are candidates for further studies to determine their functional role in inhibiting metastases in the NE-10 allograft model and human prostate cancer. PMID:19781100

  2. Applying TSOI Hybrid Learning Model to Enhance Blended Learning Experience in Science Education

    ERIC Educational Resources Information Center

    Tsoi, Mun Fie

    2009-01-01

    Purpose: Research on the nature of blended learning and its features has led to a variety of approaches to the practice of blended learning. The purpose of this paper is to provide an alternative practice model, the TSOI hybrid learning model (HLM) to enhance the blended learning experiences in science education. Design/methodology/approach: The…

  3. A Qualitative Experiment: Research on Mediated Meaning Construction Using a Hybrid Approach

    ERIC Educational Resources Information Center

    Robinson, Sue; Mendelson, Andrew L.

    2012-01-01

    This article presents a hybrid methodological technique that fuses elements of experimental design with qualitative strategies to explore mediated communication. Called the "qualitative experiment," this strategy uses focus groups and in-depth interviews "within" randomized stimulus conditions typically associated with experimental research. This…

  4. Polarimeter Arrays with Comprehensive Frequency Coverage for the Next Generation of Precision Microwave Background Experiments

    NASA Astrophysics Data System (ADS)

    Austermann, Jason Edward; Beall, James; Becker, Dan; Cho, Hsiao-Mei; Duff, Shannon; gao, jiansong; Hilton, Gene; Hubmayr, Johannes; Irwin, Kent; li, dale; McKenney, Christopher; Ullom, Joel; van lanen, jeffrey; Vissers, Michael

    2016-06-01

    Spectral resolution at (sub-)millimeter wavelengths is now understood to be crucially important in precision measurements of the cosmic microwave background (CMB). Recent results from the Planck and BICEP/KECK experiments have established that measurements of the CMB polarization signal is limited, in part, by polarized foreground emission. In particular, polarized emission from galactic dust has been found to dominate and obscure potential signals of cosmic inflation, even in regions of the sky specifically identified as having relatively low galactic emission. Current and future experiments aim to address foreground contamination by conducting high-sensitivity observations with broad spectral coverage that will allow for differentiation within the measured signal between foreground sources of polarization and that of the CMB, which each have distinct spectral characteristics. To efficiently achieve these goals within a limited focal plane area, NIST-Boulder has developed multi-band TES-based polarimeters that simultaneously measure multiple spectral bands in each of two orthogonal polarizations. This acts to both increase pixel sensitivity through an increased total bandwidth, as well as providing broad spectral information for differentiation of emission sources. Here, we describe recent achievements and ongoing efforts at NIST-Boulder in the development of millimeter and sub-millimeter detector and focal plane technologies for future experiments, including the stage-IV CMB experiment, CMB-S4. NIST-Boulder provides critical cryogenic components to a large number of current and in-development CMB experiments. Recent milestones include the fielding of the first broadband multi-chroic mm-wave polarimeters in the ACTPol experiment, multi-band array fabrication on large-format 150 mm wafers, and development of matching 150 mm silicon platelet feedhorn arrays. We also review several related development efforts in detector, optical coupling, and readout technologies

  5. Design of solid state neutral particle analyzer array for National Spherical Torus Experiment-Upgrade

    SciTech Connect

    Liu, D. Heidbrink, W. W.; Zhu, Y. B.; Tritz, K.; Roquemore, A. L.; Medley, S. S.

    2014-11-15

    A new compact, multi-channel Solid State Neutral Particle Analyzer (SSNPA) diagnostic based on silicon photodiode array has been designed and is being fabricated for the National Spherical Torus Experiment-Upgrade (NSTX-U). The SSNPA system utilizes a set of vertically stacked photodiode arrays in current mode viewing the same plasma region with different filter thickness to obtain fast temporal resolution (∼120 kHz bandwidth) and coarse energy information in three bands of >25 keV, >45 keV, and >65 keV. The SSNPA system consists of 15 radial sightlines that intersect existing on-axis neutral beams at major radii between 90 and 130 cm, 15 tangential sightlines that intersect new off-axis neutral beams at major radii between 120 and 145 cm. These two subsystems aim at separating the response of passing and trapped fast ions. In addition, one photodiode array whose viewing area does not intersect any neutral beams is used to monitor passive signals produced by fast ions that charge exchange with background neutrals.

  6. First Experiments with Planar Wire Arrays on U Michigan's Linear Transformer Driver

    NASA Astrophysics Data System (ADS)

    Safronova, A. S.; Kantsyrev, V. L.; Weller, M. E.; Shrestha, I. K.; Shlyaptseva, V. V.; Cooper, M. C.; Lorance, M.; Stafford, A.; Patel, S. G.; Steiner, A. M.; Yager-Elorriaga, D. A.; Jordan, N. M.; Gilgenbach, R. M.

    2014-10-01

    For petawatt-class Z-pinch accelerators, a Linear Transformer Driver (LTD)-driven accelerator promises to be (at a given pinch current and implosion time) more efficient than the conventionally used Marx-driven accelerator. Because there exists almost no data on how wire arrays radiate on LTD-based machines in the USA, it is very important to perform radiation and plasma physics studies on this new type of generator. We report on the first outcome of the new partnership with University of Michigan (UM), which resulted in successful UNR-UM experiments on the low-impedance MAIZE generator with planar wire arrays (PWA). PWA is a novel wire array load that was introduced and tested in detail on high-impedance Zebra at UNR during the last years and found to be the most efficient radiator. Implosion of Al Double PWAs of different configurations were achieved on MAIZE, observed with a set of various diagnostics which include x-ray diode detectors, x-ray spectroscopy and imaging, and shadowgraphy. Al and Mg plasmas of more than 450 eV were studied in detail. Research supported by NNSA under DOE Cooperative Agreement DE-NA0001984. S. G. Patel and A. M. Steiner supported by Sandia National Laboratories. D. A. Yager-Elorriaga supported by NSF GF.

  7. Fabrication of SiO2 Microdisk Arrays for Optics and Light Trapping Experiments

    SciTech Connect

    Saraf, Laxmikant V.; Engelhard, Mark H.; Lea, Alan S.

    2007-02-08

    We present a simple silicon based microfabrication process that produces an array of SiO2 microdisks using UV lithography. High-resolution SEM images of these structures indicate a smooth outer microdisk cavity surface. Photoemission measurements were performed at different spots on the microdisk and compared with measurements inside the cavity. A silicon to oxygen atomic concentration ratio of 1:2 obtained during depth profiling confirms that the entire microdisk is made up of stoichometric SiO2. In contrast, the inner cavity is mostly silicon with native oxide on top. We discuss the usefulness of SiO2 microdisks in optics for light trapping experiments.

  8. Calibration and monitoring of the air fluorescence detector for the Telescope Array experiment

    NASA Astrophysics Data System (ADS)

    Tokuno, H.; Azuma, R.; Fukushima, M.; Higashide, Y.; Inoue, N.; Kadota, K.; Kakimoto, F.; Kawana, S.; Murano, Y.; Ogio, S.; Sakurai, N.; Sagawa, H.; Shibata, T.; Takeda, M.; Taketa, A.; Tameda, Y.; Tsunesada, Y.; Udo, S.; Yoshida, S.; Telescope Array Collaboration

    The air fluorescence detectors (FDs) of the Telescope Array (TA) experiment have been constructed in a dessert of Utah, USA. We can measure the longitudinal developments of EASs directly with the FDs by detecting air fluorescence lights and determine the primary energies of ultra-high energy cosmic rays. In order for accurate observation and measurements of EASs, elaborate detector calibrations and monitoring systems are required. We will present the result of calibration and monitoring systems for the reflectance and curvature radius of segment mirrors, the characteristics of PMT (absolute gain, linearity, temperature dependence of gain), and the uniformity of the camera surface, etc.

  9. Experience with a multiprocessor based on eight FPS 120B array processors

    SciTech Connect

    Bucher, I.Y.; Frederickson, P.O.; Moore, J.W.

    1981-01-01

    The rate of increase in the speed of monoprocessors is no longer keeping pace with the needs of the laboratory; accordingly, the use of parallel processors in large scientific computations is being investigated. As an initial experiment, a particle-in-cell plasma simulation was adapted to run on a star graph architecture consisting of a UNIVAC 1110 as hub, and up to eight Floating Point Systems AP120B array processors at the other vertices. Subdivision of tasks among processors and measured results are discussed.

  10. Are hybrid models integrated with data preprocessing techniques suitable for monthly streamflow forecasting? Some experiment evidences

    NASA Astrophysics Data System (ADS)

    Zhang, Xiaoli; Peng, Yong; Zhang, Chi; Wang, Bende

    2015-11-01

    A number of hydrological studies have proven the superior prediction performance of hybrid models coupled with data preprocessing techniques. However, many studies first decompose the entire data series into components and later divide each component into calibration and validation datasets to establish models, which sends some amount of future information into the decomposition and reconstruction processes. As a consequence, the resulting components used to forecast the value of a particular moment are computed using information from future values, which are not available at that particular moment in a forecasting exercise. Since most papers don't present their model framework in detail, it is difficult to identify whether they are performing a real forecast or not. Even though several other papers have explicitly stated which experiment they are performing, a comparison between results in the hindcast and forecast experiments is still missing. Therefore, it is necessary to investigate and compare the performance of these hybrid models in the two experiments in order to estimate whether they are suitable for real forecasting. With the combination of three preprocessing techniques, such as wavelet analysis (WA), empirical mode decomposition (EMD) and singular spectrum analysis (SSA), and two modeling methods (i.e. ANN model and ARMA model), six hybrid models are developed in this study, including WA-ANN, WA-ARMA, EMD-ANN, EMD-ARMA, SSA-ANN and SSA-ARMA. Preprocessing techniques are used to decompose the data series into sub-series, and then these sub-series are modeled using ANN and ARMA models. These models are examined in hindcasting and forecasting of the monthly streamflow of two sites in the Yangtze River of China. The results of this study indicate that the six hybrid models perform better in the hindcast experiment compared with the original ANN and ARMA models, while the hybrid models in the forecast experiment perform worse than the original models and the

  11. Experimental study of surface insulated-standard hybrid tungsten planar wire array Z-pinches at "QiangGuang-I" facility

    NASA Astrophysics Data System (ADS)

    Sheng, Liang; Peng, Bodong; Li, Yang; Yuan, Yuan; Li, Mo; Zhang, Mei; Zhao, Chen; Zhao, Jizhen; Wang, Liangping

    2016-01-01

    The experimental results of the insulated-standard hybrid wire array Z pinches carried out on "QiangGuang-I" facility at Northwest Institute of Nuclear Technology were presented and discussed. The surface insulating can impose a significant influence on the dynamics and radiation characteristics of the hybrid wire array Z pinches, especially on the early stage (t/timp < 0.6). The expansion of insulated wires at the ablation stage is suppressed, while the streams stripped from the insulated wires move faster than that from the standard wires. The foot radiation of X-ray is enhanced by increment of the number of insulated wires, 19.6 GW, 33.6 GW, and 68.6 GW for shots 14037S, 14028H, and 14039I, respectively. The surface insulation also introduces nonhomogeneity along the single wire—the streams move much faster near the electrodes. The colliding boundary of the hybrid wire array Z pinches is bias to the insulated side approximately 0.6 mm.

  12. BICEP2/Keck Array. IV. Optical Characterization and Performance of the BICEP2 and Keck Array Experiments

    NASA Astrophysics Data System (ADS)

    Ade, P. A. R.; Aikin, R. W.; Barkats, D.; Benton, S. J.; Bischoff, C. A.; Bock, J. J.; Bradford, K. J.; Brevik, J. A.; Buder, I.; Bullock, E.; Dowell, C. D.; Duband, L.; Filippini, J. P.; Fliescher, S.; Golwala, S. R.; Halpern, M.; Hasselfield, M.; Hildebrandt, S. R.; Hilton, G. C.; Hui, H.; Irwin, K. D.; Kang, J. H.; Karkare, K. S.; Kaufman, J. P.; Keating, B. G.; Kefeli, S.; Kernasovskiy, S. A.; Kovac, J. M.; Kuo, C. L.; Leitch, E. M.; Lueker, M.; Megerian, K. G.; Netterfield, C. B.; Nguyen, H. T.; O’Brient, R.; Ogburn, R. W., IV; Orlando, A.; Pryke, C.; Richter, S.; Schwarz, R.; Sheehy, C. D.; Staniszewski, Z. K.; Sudiwala, R. V.; Teply, G. P.; Thompson, K.; Tolan, J. E.; Turner, A. D.; Vieregg, A. G.; Weber, A. C.; Wong, C. L.; Yoon, K. W.; bicep2, The; Keck Array Collaborations

    2015-06-01

    bicep2 and the Keck Array are polarization-sensitive microwave telescopes that observe the cosmic microwave background (CMB) from the South Pole at degree angular scales in search of a signature of inflation imprinted as B-mode polarization in the CMB. bicep2 was deployed in late 2009, observed for three years until the end of 2012 at 150 GHz with 512 antenna-coupled transition edge sensor bolometers, and has reported a detection of B-mode polarization on degree angular scales. The Keck Array was first deployed in late 2010 and will observe through 2016 with five receivers at several frequencies (95, 150, and 220 GHz). bicep2 and the Keck Array share a common optical design and employ the field-proven bicep1 strategy of using small-aperture, cold, on-axis refractive optics, providing excellent control of systematics while maintaining a large field of view. This design allows for full characterization of far-field optical performance using microwave sources on the ground. Here we describe the optical design of both instruments and report a full characterization of the optical performance and beams of bicep2 and the Keck Array at 150 GHz.

  13. Dynamic experiment design regularization approach to adaptive imaging with array radar/SAR sensor systems.

    PubMed

    Shkvarko, Yuriy; Tuxpan, José; Santos, Stewart

    2011-01-01

    We consider a problem of high-resolution array radar/SAR imaging formalized in terms of a nonlinear ill-posed inverse problem of nonparametric estimation of the power spatial spectrum pattern (SSP) of the random wavefield scattered from a remotely sensed scene observed through a kernel signal formation operator and contaminated with random Gaussian noise. First, the Sobolev-type solution space is constructed to specify the class of consistent kernel SSP estimators with the reproducing kernel structures adapted to the metrics in such the solution space. Next, the "model-free" variational analysis (VA)-based image enhancement approach and the "model-based" descriptive experiment design (DEED) regularization paradigm are unified into a new dynamic experiment design (DYED) regularization framework. Application of the proposed DYED framework to the adaptive array radar/SAR imaging problem leads to a class of two-level (DEED-VA) regularized SSP reconstruction techniques that aggregate the kernel adaptive anisotropic windowing with the projections onto convex sets to enforce the consistency and robustness of the overall iterative SSP estimators. We also show how the proposed DYED regularization method may be considered as a generalization of the MVDR, APES and other high-resolution nonparametric adaptive radar sensing techniques. A family of the DYED-related algorithms is constructed and their effectiveness is finally illustrated via numerical simulations. PMID:22163859

  14. Hybridization of the Vector Finite Element Method with the Boundary Integral Method for the Solution of Finite Arrays of Cavity-Backed Slot Antennas

    NASA Astrophysics Data System (ADS)

    Polycarpou, A. C.

    2009-10-01

    The vector finite element method (FEM) is hybridized with the boundary integral (BI) method to solve for the radiation characteristics of a cavity-backed slot (CBS) antenna. The hybridization of the two methods is made possible at the aperture of the antenna separating the cavity interior and the half-space exterior region above an infinite conducting ground plane. Having to solve for a finite array of CBS antennas requires an excessive amount of memory, in order to store the system matrix, and considerable CPU time for the solution of the resulting linear system of equations. Increasing the number of array elements results in a non-linear increase in the number of unknowns, thus making the solution of the linear system impossible. In this paper, we adopt array domain decomposition (ADD) and by taking advantage of the repetitive features of the array, we can reduce the memory requirements to a minimum. In addition, we introduce stationary and non-stationary iteration techniques, with or without preconditioning, to solve the system of linear equations in an efficient manner. Singular value decomposition (SVD) is also used in order to further reduce memory requirements and speed-up matrix-vector multiplications that are inherent in either type of iterative techniques. Computational statistics and comparisons between stationary and non-stationary techniques are presented and discussed.

  15. Real-time detection of DNA hybridization on microarray using a CCD-based imaging system equipped with a rotated microlens array disk.

    PubMed

    Mogi, Takeyuki; Hatakeyama, Keiichi; Taguchi, Tomoyuki; Wake, Hitoshi; Tanaami, Takeo; Hosokawa, Masahito; Tanaka, Tsuyoshi; Matsunaga, Tadashi

    2011-01-15

    This work describes a novel charge-coupled device (CCD)-based imaging system (MB Biochip Reader™) for real-time detection of DNA hybridization to DNA microarrays. The MB Biochip Reader™ consisted of a laser light source (532 nm), a microlens array for generation of a multi-beam laser, and a CCD for 2-D signal imaging. The MB Biochip Reader™ with a rotated microlens array, allowed large-field imaging (6.2 mm × 7.6 mm with 6.45 μm resolution) with fast time-resolution at 0.2 s without speckle noise. Furthermore, real-time detection of DNA hybridization, which is sufficient to obtain accurate data from tens of thousands of array element per field, was successfully performed without the need for laser scanning. The performance of the MB Biochip Reader™ for DNA microarray imaging was similar to the commercially available photomultiplier tube (PMT)-based microarray scanner, ScanArray Lite. The system potentially could be applied toward real-time analysis in many other fluorescent techniques in addition to real-time DNA microarray analysis. PMID:20951567

  16. Binder-free Co3O4@NiCoAl-layered double hydroxide core-shell hybrid architectural nanowire arrays with enhanced electrochemical performance

    NASA Astrophysics Data System (ADS)

    Li, Xuan; Yang, Zhengchun; Qi, Wen; Li, Yutao; Wu, Ying; Zhou, Shaoxiong; Huang, Shengming; Wei, Jun; Li, Huijun; Yao, Pei

    2016-02-01

    Herein, binder-free Co3O4@NiCoAl-layered double hydroxide (Co3O4@LDH) core-shell hybrid architectural nanowire arrays were prepared via a two-step hydrothermal synthesis route. LDH nanosheets possessing a large electroactive surface area uniformly dispersed on the surface of Co3O4 nanowires were successfully fabricated allowing for fast electron transport that enhances the electrochemical performance of LDH nanosheets. Co3O4@LDH nanowire arrays of 2 to 1.5 molar ratio (Co3O4:LDH) exhibit high specific capacitance (1104 F g-1 at 1 A g-1), adequate rate capability and cycling stability (87.3% after 5000 cycles), attributed to the synergistic effect between the robust Co3O4 nanowire arrays and LDH nanosheets.

  17. Electron Cyclotron / Bernstein Wave Heating and Current Drive Experiments using Phased-array Antenna in QUEST

    SciTech Connect

    Idei, H.; Zushi, H.; Hanada, K.; Nakamura, K.; Fujisawa, A.; Hasegawa, M.; Yoshida, N.; Watanebe, H.; Tokunaga, K.; Nagashima, Y.; Kawasaki, S.; Nakashima, H.; Higashijima, A.; Sakamoto, M.; Ejiri, A.; Takase, Y.; Sakaguchi, M.; Kalinnikova, E.; Ishiguro, M.; Tashima, S.

    2011-12-23

    The phased-array antenna system for Electron Cyclotron/Bernstein Wave Heating and Current Drive experiments has been developed in the QUEST. The antenna was designed to excite a pure O-mode wave in the oblique injection for the O-X-B mode conversion experiments, and its good performances were confirmed at a low power level. The plasma current (<{approx}15 kA) with an aspect ratio of 1.5 was started up and sustained by only RF injection in the low-density operations. The long pulse discharge of 10 kA was also attained for 37 s. The new density window to sustain the plasma current was observed in the high-density plasmas. The single-null divertor configuration with the high plasma current (<{approx}25 kA) was attained in the 17 s plasma sustainment.

  18. Artificial plasma cusp generated by upper hybrid instabilities in HF heating experiments at HAARP

    NASA Astrophysics Data System (ADS)

    Kuo, Spencer; Snyder, Arnold

    2013-05-01

    High Frequency Active Auroral Research Program digisonde was operated in a fast mode to record ionospheric modifications by the HF heating wave. With the O mode heater of 3.2 MHz turned on for 2 min, significant virtual height spread was observed in the heater off ionograms, acquired beginning the moment the heater turned off. Moreover, there is a noticeable bump in the virtual height spread of the ionogram trace that appears next to the plasma frequency (~ 2.88 MHz) of the upper hybrid resonance layer of the HF heating wave. The enhanced spread and the bump disappear in the subsequent heater off ionograms recorded 1 min later. The height distribution of the ionosphere in the spread situation indicates that both electron density and temperature increases exceed 10% over a large altitude region (> 30 km) from below to above the upper hybrid resonance layer. This "mini cusp" (bump) is similar to the cusp occurring in daytime ionograms at the F1-F2 layer transition, indicating that there is a small ledge in the density profile reminiscent of F1-F2 layer transitions. Two parametric processes exciting upper hybrid waves as the sidebands by the HF heating waves are studied. Field-aligned purely growing mode and lower hybrid wave are the respective decay modes. The excited upper hybrid and lower hybrid waves introduce the anomalous electron heating which results in the ionization enhancement and localized density ledge. The large-scale density irregularities formed in the heat flow, together with the density irregularities formed through the parametric instability, give rise to the enhanced virtual height spread. The results of upper hybrid instability analysis are also applied to explain the descending feature in the development of the artificial ionization layers observed in electron cyclotron harmonic resonance heating experiments.

  19. Experiments on Nitrogen Oxide Production of Droplet Arrays Burning under Microgravity Conditions

    NASA Astrophysics Data System (ADS)

    Moesl, Klaus; Sattelmayer, Thomas; Kikuchi, Masao; Yamamoto, Shin; Yoda, Shinichi

    The optimization of the combustion process is top priority in current aero-engine and aircraft development, particularly from the perspectives of high efficiency, minimized fuel consumption, and a sustainable exhaust gas production. Aero-engines are exclusively liquid-fueled with a strong correlation between the combustion temperature and the emissions of nitric oxide (NOX ). Due to safety concerns, the progress in NOX reduction has been much slower than in stationary gas turbines. In the past, the mixing intensity in the primary zone of aero-engine combustors was improved and air staging implemented. An important question for future aero-engine combustors, consequently, is how partial vaporization influences the NOX emissions of spray flames? In order to address this question, the combustion of partially vaporized, linear droplet arrays was studied experimentally under microgravity conditions. The influence of fuel pre-vaporization on the NOX emissions was assessed in a wide range. The experiments were performed in a drop tower and a sounding rocket campaign. The microgravity environment provided ideal experiment conditions without the disturbing ef-fect of natural convection. This allowed the study of the interacting phenomena of multi-phase flow, thermodynamics, and chemical kinetics. This way the understanding of the physical and chemical processes related to droplet and spray combustion could be improved. The Bremen drop tower (ZARM) was utilized for the precursor campaign in July 2008, which was com-prised of 30 drops. The sounding rocket experiments, which totaled a microgravity duration of 6 minutes, were finally performed on the flight of TEXUS-46 in November 2009. On both campaigns the "Japanese Combustion Module" (JCM) was used. It is a cooperative experi-ment on droplet array combustion between the Japan Aerospace Exploration Agency (JAXA) and ESA's (European Space Agency) research team, working on the combustion properties of partially premixed sprays

  20. High-resolution genomic profiles of breast cancer cell lines assessed by tiling BAC array comparative genomic hybridization.

    PubMed

    Jönsson, Göran; Staaf, Johan; Olsson, Eleonor; Heidenblad, Markus; Vallon-Christersson, Johan; Osoegawa, Kazutoyo; de Jong, Pieter; Oredsson, Stina; Ringnér, Markus; Höglund, Mattias; Borg, Ake

    2007-06-01

    A BAC-array platform for comparative genomic hybridization was constructed from a library of 32,433 clones providing complete genome coverage, and evaluated by screening for DNA copy number changes in 10 breast cancer cell lines (BT474, MCF7, HCC1937, SK-BR-3, L56Br-C1, ZR-75-1, JIMT1, MDA-MB-231, MDA-MB-361, and HCC2218) and one cell line derived from fibrocystic disease of the breast (MCF10A). These were also characterized by gene expression analysis and found to represent all five recently described breast cancer subtypes using the "intrinsic gene set" and centroid correlation. Three cell lines, HCC1937 and L56BrC1 derived from BRCA1 mutation carriers and MDA-MB-231, were of basal-like subtype and characterized by a high frequency of low-level gains and losses of typical pattern, including limited deletions on 5q. Four estrogen receptor positive cell lines were of luminal A subtype and characterized by a different pattern of aberrations and high-level amplifications, including ERBB2 and other 17q amplicons in BT474 and MDA-MB-361. SK-BR-3 cells, characterized by a complex genome including ERBB2 amplification, massive high-level amplifications on 8q and a homozygous deletion of CDH1 at 16q22, had an expression signature closest to luminal B subtype. The effects of gene amplifications were verified by gene expression analysis to distinguish targeted genes from silent amplicon passengers. JIMT1, derived from an ERBB2 amplified trastuzumab resistant tumor, was of the ERBB2 subtype. Homozygous deletions included other known targets such as PTEN (HCC1937) and CDKN2A (MDA-MB-231, MCF10A), but also new candidate suppressor genes such as FUSSEL18 (HCC1937) and WDR11 (L56Br-C1) as well as regions without known genes. The tiling BAC-arrays constitute a powerful tool for high-resolution genomic profiling suitable for cancer research and clinical diagnostics. PMID:17334996

  1. Widespread, focal copy number variations (CNV) and whole chromosome aneuploidies in Trypanosoma cruzi strains revealed by array comparative genomic hybridization

    PubMed Central

    2011-01-01

    Background Trypanosoma cruzi is a protozoan parasite and the etiologic agent of Chagas disease, an important public health problem in Latin America. T. cruzi is diploid, almost exclusively asexual, and displays an extraordinarily diverse population structure both genetically and phenotypically. Yet, to date the genotypic diversity of T. cruzi and its relationship, if any, to biological diversity have not been studied at the whole genome level. Results In this study, we used whole genome oligonucleotide tiling arrays to compare gene content in biologically disparate T. cruzi strains by comparative genomic hybridization (CGH). We observed that T. cruzi strains display widespread and focal copy number variations (CNV) and a substantially greater level of diversity than can be adequately defined by the current genetic typing methods. As expected, CNV were particularly frequent in gene family-rich regions containing mucins and trans-sialidases but were also evident in core genes. Gene groups that showed little variation in copy numbers among the strains tested included those encoding protein kinases and ribosomal proteins, suggesting these loci were less permissive to CNV. Moreover, frequent variation in chromosome copy numbers were observed, and chromosome-specific CNV signatures were shared by genetically divergent T. cruzi strains. Conclusions The large number of CNV, over 4,000, reported here uphold at a whole genome level the long held paradigm of extraordinary genome plasticity among T. cruzi strains. Moreover, the fact that these heritable markers do not parse T. cruzi strains along the same lines as traditional typing methods is strongly suggestive of genetic exchange playing a major role in T. cruzi population structure and biology. PMID:21385342

  2. Theory and design of compact hybrid microphone arrays on two-dimensional planes for three-dimensional soundfield analysis.

    PubMed

    Chen, Hanchi; Abhayapala, Thushara D; Zhang, Wen

    2015-11-01

    Soundfield analysis based on spherical harmonic decomposition has been widely used in various applications; however, a drawback is the three-dimensional geometry of the microphone arrays. In this paper, a method to design two-dimensional planar microphone arrays that are capable of capturing three-dimensional (3D) spatial soundfields is proposed. Through the utilization of both omni-directional and first order microphones, the proposed microphone array is capable of measuring soundfield components that are undetectable to conventional planar omni-directional microphone arrays, thus providing the same functionality as 3D arrays designed for the same purpose. Simulations show that the accuracy of the planar microphone array is comparable to traditional spherical microphone arrays. Due to its compact shape, the proposed microphone array greatly increases the feasibility of 3D soundfield analysis techniques in real-world applications. PMID:26627782

  3. From MAD to SAD: The Italian experience for the low-frequency aperture array of SKA1-LOW

    NASA Astrophysics Data System (ADS)

    Bolli, P.; Pupillo, G.; Virone, G.; Farooqui, M. Z.; Lingua, A.; Mattana, A.; Monari, J.; Murgia, M.; Naldi, G.; Paonessa, F.; Perini, F.; Pluchino, S.; Rusticelli, S.; Schiaffino, M.; Schillirò, F.; Tartarini, G.; Tibaldi, A.

    2016-03-01

    This paper describes two small aperture array demonstrators called Medicina and Sardinia Array Demonstrators (MAD and SAD, respectively). The objectives of these instruments are to acquire experience and test new technologies for a possible application to the low-frequency aperture array of the low-frequency telescope of the Square Kilometer Array phase 1 (SKA1-LOW). The MAD experience was concluded in 2014, and it turned out to be an important test bench for implementing calibration techniques based on an artificial source mounted in an aerial vehicle. SAD is based on 128 dual-polarized Vivaldi antennas and is 1 order of magnitude larger than MAD. The architecture and the station size of SAD, which is along the construction phase, are more similar to those under evaluation for SKA1-LOW, and therefore, SAD is expected to provide useful hints for SKA1-LOW.

  4. Rational construction of three dimensional hybrid Co3O4@NiMoO4 nanosheets array for energy storage application

    NASA Astrophysics Data System (ADS)

    Hong, Wei; Wang, Jinqing; Gong, Peiwei; Sun, Jinfeng; Niu, Lengyuan; Yang, Zhigang; Wang, Zhaofeng; Yang, Shengrong

    2014-12-01

    Electrodes with rationally designed hybrid nanostructures can offer many opportunities for the enhanced performance in electrochemical energy storage. In this work, the uniform 2D Co3O4-based building blocks have been prepared through a facile chemical etching assistant approach and a following treatment of thermal annealing. The obtained nanosheets array has been directly employed as 2D backbone for the subsequent construction of hybrid nanostructure of Co3O4@NiMoO4 by a simple hydrothermal synthesis. As a binder-free electrode, the constructed 3D hybrid nanostructures exhibit a high specific capacitance of 1526 F g-1 at a current density of 3 mA cm-2 and a capacitance retention of 72% with the increase of current density from 3 mA cm-2 to 30 mA cm-2. Moreover, an asymmetric supercapacitor based on this hybrid Co3O4@NiMoO4 and activated carbon can deliver a maximum energy density of 37.8 Wh kg-1 at a power density of 482 W kg-1. The outstanding electrochemical behaviors presented here suggest that this hybrid nanostructured material has potential applications in energy storage.

  5. MHD Stability Analysis Using an X-ray Wave Array Diagnostic on the PEGASUS Toroidal Experiment*

    NASA Astrophysics Data System (ADS)

    Wilson, C.; Fonck, R.; Intrator, T.; Thorson, T.

    1998-11-01

    Tearing mode instabilities during plasma current ramp-up are important for extremely low aspect ratio devices. Fast current ramping, aided by the low internal inductance of low aspect ratio plasmas, induces skin currents. The resulting hollow current profile may produce double tearing modes, which allows for reconnection and current penetration. Another area of interest for MHD stability studies in the first phase of operation of the P EGASUS Experiment is the nature of the plasma stability boundary as the edge-q is lowered at extremely low aspect ratio. This boundary plays a major role in the accessibility to stable operation at very low toroidal field. P EGASUS will employ an X-ray diode (XRD) detector array to diagnose the internal plasma MHD structure. We are designing and installing a vertical 20 channel radially viewing pinhole array of XRD's for >= 50 eV photon measurement. Each channel will have a vertical resolution of 2 cm and an upper frequency limit of 100 kHz. The lithium drifted XRD's have a large surface area of 90 mm^2, thereby being quite sensitive and suited to a low temperature start-up plasma. The expected signal-to-noise ratio due to photon noise is < 0.1% for P EGASUS plasmas. * *Supported by U.S. DoE grant No. DE-FG02-96ER54375

  6. Development of arrays of Silicon Drift Detectors and readout ASIC for the SIDDHARTA experiment

    NASA Astrophysics Data System (ADS)

    Quaglia, R.; Schembari, F.; Bellotti, G.; Butt, A. D.; Fiorini, C.; Bombelli, L.; Giacomini, G.; Ficorella, F.; Piemonte, C.; Zorzi, N.

    2016-07-01

    This work deals with the development of new Silicon Drift Detectors (SDDs) and readout electronics for the upgrade of the SIDDHARTA experiment. The detector is based on a SDDs array organized in a 4×2 format with each SDD square shaped with 64 mm2 (8×8) active area. The total active area of the array is therefore 32×16 mm2 while the total area of the detector (including 1 mm border dead area) is 34 × 18mm2. The SIDDHARTA apparatus requires 48 of these modules that are designed and manufactured by Fondazione Bruno Kessler (FBK). The readout electronics is composed by CMOS preamplifiers (CUBEs) and by the new SFERA (SDDs Front-End Readout ASIC) circuit. SFERA is a 16-channels readout ASIC designed in a 0.35 μm CMOS technology, which features in each single readout channel a high order shaping amplifier (9th order Semi-Gaussian complex-conjugate poles) and a high efficiency pile-up rejection logic. The outputs of the channels are connected to an analog multiplexer for the external analog to digital conversion. An on-chip 12-bit SAR ADC is also included. Preliminary measurements of the detectors in the single SDD format are reported. Also measurements of low X-ray energies are reported in order to prove the possible extension to the soft X-ray range.

  7. Defining ploidy-specific thresholds in array comparative genomic hybridization to improve the sensitivity of detection of single copy alterations in cell lines.

    PubMed

    Ng, Grace; Huang, Jingxiang; Roberts, Ian; Coleman, Nicholas

    2006-09-01

    Array comparative genomic hybridization (CGH) is being widely used to screen for recurrent genomic copy number alterations in neoplasms, with imbalances typically detected through the application of gain and loss thresholds. Review of array CGH publications for the year 2005 showed that a wide range of thresholds are used. However, the effect of sample ploidy on the sensitivity of these thresholds for single copy alterations (SCAs) has not been evaluated. Here, we describe a method to evaluate the detection accuracy of thresholds for detecting SCAs in cell line array CGH data. By applying a hidden Markov model-based method, we segmented array CGH data from well-karyotyped cell lines and generated ploidy-specific sensitivity-specificity plots, from which we identified optimum thresholds relevant to sample ploidy. We demonstrate that commonly used nonploidy-specific thresholds are suboptimal in their ability to call SCAs, particularly when applied to hypertriploid or tetraploid cell lines. We conclude that the use of ploidy-specific thresholds improves the sensitivity of thres-hold-based array CGH for detecting SCAs in cell lines. Because polyploidy is a common feature of cancer cells, the application of ploidy-specific thresholds to cell lines (and potentially to clinical samples) may improve the detection sensitivity of SCAs of biological significance. PMID:16931585

  8. Selective Recognition of 5-Hydroxytryptamine and Dopamine on a Multi-Walled Carbon Nanotube-Chitosan Hybrid Film-Modified Microelectrode Array

    PubMed Central

    Xu, Huiren; Wang, Li; Luo, Jinping; Song, Yilin; Liu, Juntao; Zhang, Song; Cai, Xinxia

    2015-01-01

    It is difficult to determine dopamine (DA) and 5-hydroxytryptamine (5-HT) accurately because of the interference of ascorbic acid (AA) in vitro, which has a high concentration and can be oxidized at a potential close to DA and 5-HT at a conventional electrode, combined with the overlapping voltammetric signal of DA and 5-HT at a bare electrode. Herein, chitosan (CS) was used as a stabilizing matrix by electrochemical reaction, and multi-walled carbon nanotubes (MWCNTs) were modified onto the microelectrode array (MEA). The CS-MWCNT hybrid film-modified MEA was quite effective at simultaneously recognizing these species in a mixture and resolved the overlapping anodic peaks of AA, DA and 5-HT into three well-defined oxidation peaks in differential pulse voltammetry (DPV) at −80 mV, 105 mV and 300 mV (versus Ag|AgCl), respectively. The linear responses were obtained in the range of 5 × 10−6 M to 2 × 10−4 M for DA (r = 0.996) and in the range of 1 × 10−5 M to 3 × 10−4 M for 5-HT (r = 0.999) using the DPV under the presence of a single substance. While DA coexisted with 5-HT in the interference of 3 × 10−4 M AA, the linear responses were obtained in the range of 1 × 10−5 M to 3 × 10−4 M for selective molecular recognition of DA (r = 0.997) and 5-HT (r = 0.997) using the DPV. Therefore, this proposed MEA was successfully used for selective molecular recognition and determination of DA and 5-HT using the DPV, which has a potential application for real-time determination in vitro experiments. PMID:25580900

  9. Adaptive Array for Weak Interfering Signals: Geostationary Satellite Experiments. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Steadman, Karl

    1989-01-01

    The performance of an experimental adaptive array is evaluated using signals from an existing geostationary satellite interference environment. To do this, an earth station antenna was built to receive signals from various geostationary satellites. In these experiments the received signals have a frequency of approximately 4 GHz (C-band) and have a bandwidth of over 35 MHz. These signals are downconverted to a 69 MHz intermediate frequency in the experimental system. Using the downconverted signals, the performance of the experimental system for various signal scenarios is evaluated. In this situation, due to the inherent thermal noise, qualitative instead of quantitative test results are presented. It is shown that the experimental system can null up to two interfering signals well below the noise level. However, to avoid the cancellation of the desired signal, the use a steering vector is needed. Various methods to obtain an estimate of the steering vector are proposed.

  10. Definition Study for Space Shuttle Experiments Involving Large, Steerable Millimeter-Wave Antenna Arrays

    NASA Technical Reports Server (NTRS)

    Levis, C. A.

    1976-01-01

    The potential uses and techniques for the shuttle spacelab Millimeter Wave Large Aperture Antenna Experiment (MWLAE) are documented. Potential uses are identified: applications to radio astronomy, the sensing of atmospheric turbulence by its effect on water vapor line emissions, and the monitoring of oil spills by multifrequency radiometry. IF combining is preferable to RF combining with respect to signal to noise ratio for communications receiving antennas of the size proposed for MWLAE. A design approach using arrays of subapertures is proposed to reduce the number of phase shifters and mixers for uses which require a filled aperture. Correlation radiometry and a scheme utilizing synchronous Dicke switches and IF combining are proposed as potential solutions.

  11. A 4-channel 3 Tesla phased array receive coil for awake rhesus monkey fMRI and diffusion MRI experiments

    PubMed Central

    Khachaturian, Mark Haig

    2010-01-01

    Awake monkey fMRI and diffusion MRI combined with conventional neuroscience techniques has the potential to study the structural and functional neural network. The majority of monkey fMRI and diffusion MRI experiments are performed with single coils which suffer from severe EPI distortions which limit resolution. By constructing phased array coils for monkey MRI studies, gains in SNR and anatomical accuracy (i.e., reduction of EPI distortions) can be achieved using parallel imaging. The major challenges associated with constructing phased array coils for monkeys are the variation in head size and space constraints. Here, we apply phased array technology to a 4-channel phased array coil capable of improving the resolution and image quality of full brain awake monkey fMRI and diffusion MRI experiments. The phased array coil is that can adapt to different rhesus monkey head sizes (ages 4–8) and fits in the limited space provided by monkey stereotactic equipment and provides SNR gains in primary visual cortex and anatomical accuracy in conjunction with parallel imaging and improves resolution in fMRI experiments by a factor of 2 (1.25 mm to 1.0 mm isotropic) and diffusion MRI experiments by a factor of 4 (1.5 mm to 0.9 mm isotropic). PMID:21243106

  12. Hybrid Reynolds-Averaged/Large-Eddy Simulations of a Coaxial Supersonic Free-Jet Experiment

    NASA Technical Reports Server (NTRS)

    Baurle, Robert A.; Edwards, Jack R.

    2010-01-01

    Reynolds-averaged and hybrid Reynolds-averaged/large-eddy simulations have been applied to a supersonic coaxial jet flow experiment. The experiment was designed to study compressible mixing flow phenomenon under conditions that are representative of those encountered in scramjet combustors. The experiment utilized either helium or argon as the inner jet nozzle fluid, and the outer jet nozzle fluid consisted of laboratory air. The inner and outer nozzles were designed and operated to produce nearly pressure-matched Mach 1.8 flow conditions at the jet exit. The purpose of the computational effort was to assess the state-of-the-art for each modeling approach, and to use the hybrid Reynolds-averaged/large-eddy simulations to gather insight into the deficiencies of the Reynolds-averaged closure models. The Reynolds-averaged simulations displayed a strong sensitivity to choice of turbulent Schmidt number. The initial value chosen for this parameter resulted in an over-prediction of the mixing layer spreading rate for the helium case, but the opposite trend was observed when argon was used as the injectant. A larger turbulent Schmidt number greatly improved the comparison of the results with measurements for the helium simulations, but variations in the Schmidt number did not improve the argon comparisons. The hybrid Reynolds-averaged/large-eddy simulations also over-predicted the mixing layer spreading rate for the helium case, while under-predicting the rate of mixing when argon was used as the injectant. The primary reason conjectured for the discrepancy between the hybrid simulation results and the measurements centered around issues related to the transition from a Reynolds-averaged state to one with resolved turbulent content. Improvements to the inflow conditions were suggested as a remedy to this dilemma. Second-order turbulence statistics were also compared to their modeled Reynolds-averaged counterparts to evaluate the effectiveness of common turbulence closure

  13. High-resolution mapping of genotype-phenotype relationships in cridu chat syndrome using array comparative genomic hybridization

    SciTech Connect

    Zhang, Xiaoxiao; Snijders, Antoine; Segraves, Richard; Zhang,Xiuqing; Niebuhr, Anita; Albertson, Donna; Yang, Huanming; Gray, Joe; Niebuhr, Erik; Bolund, Lars; Pinkel, Dan

    2007-07-03

    We have used array comparative genomic hybridization to map DNA copy-number changes in 94 patients with cri du chat syndrome who had been carefully evaluated for the presence of the characteristic cry, speech delay, facial dysmorphology, and level of mental retardation (MR). Most subjects had simple deletions involving 5p (67 terminal and 12 interstitial). Genotype-phenotype correlations localized the region associated with the cry to 1.5 Mb in distal 5p15.31, between bacterial artificial chromosomes (BACs) containing markers D5S2054 and D5S676; speech delay to 3.2 Mb in 5p15.32-15.33, between BACs containing D5S417 and D5S635; and the region associated with facial dysmorphology to 2.4 Mb in 5p15.2-15.31, between BACs containing D5S208 and D5S2887. These results overlap and refine those reported in previous publications. MR depended approximately on the 5p deletion size and location, but there were many cases in which the retardation was disproportionately severe, given the 5p deletion. All 15 of these cases, approximately two-thirds of the severely retarded patients, were found to have copy-number aberrations in addition to the 5p deletion. Restriction of consideration to patients with only 5p deletions clarified the effect of such deletions and suggested the presence of three regions, MRI-III, with differing effect on retardation. Deletions including MRI, a 1.2-Mb region overlapping the previously defined cri du chat critical region but not including MRII and MRIII, produced a moderate level of retardation. Deletions restricted to MRII, located just proximal to MRI, produced a milder level of retardation, whereas deletions restricted to the still-more proximal MRIII produced no discernible phenotype. However, MR increased as deletions that included MRI extended progressively into MRII and MRIII, and MR became profound when all three regions were deleted.

  14. Minimum Information Specification For In Situ Hybridization and Immunohistochemistry Experiments (MISFISHIE)

    SciTech Connect

    Deutsch, Eric W.; Ball, Catherine A.; Berman, Jules J.; Bova, G. Steven; Brazma, Alvis; Bumgarner, Roger E.; Campbell, David; Causton, Helen C.; Christiansen, Jeff; Daian, Fabrice; Dauga, Delphine; Davidson, Duncan; Gimenez, Gregory; Goo, Young Ah; Grimmond, Sean; Henrich, Thorsten; Herrmann, Bernhard G.; Johnson, Michael H.; Korb, Martin; Mills, Jason C.; Oudes, Asa; Parkinson, Helen E.; Pascal, Laura E.; Pollet, Nicolas; Quackenbush, John; Ramaialison, Mirana; Ringwald, Martin; Salgado, David; Sansone, Susanna A.; Sherlock, Gavin; Stoeckert, Christian Jr. J.; Swedlow, Jason; Taylor, Ronald C.; Walasheck, Laura; Warford, Anthony; Wilkinson, David G.; Zhou, Yi; Zon, Leonard I.; Liu, Alvin Y.; True, Lawrence D.

    2008-03-28

    Herein, we present for consideration such a specification, termed “Minimum Information Specification For In Situ Hybridization and Immunohistochemistry Experiments (MISFISHIE)”. It is modelled after the MIAME (Minimum Information About a Microarray Experiment) specification for microarray experiments. The purpose of data standards like MIAME and MISFISHIE is to specify information content without specifying a format for encoding that information. The MISFISHIE standard specifies six sections of information that must be detailed for each experiment: Experimental Design, Specimens, Reporters, Staining, Imaging Data, and Image Characterizations. A general checklist is provided to quickly and efficiently establish adherence to the standard. Currently, we estimate that most articles describing gene expression localization studies, such as in situ hybridization assays, do not fully provide the minimum information needed for independent verification of results. In a small survey of 32 journal articles from the past five years, we found that nearly 90% did not meet all the requirements, although many met most of them. We propose that requiring authors to provide the minimum experimental detail about gene expression localization experiments would substantially facilitate reproducibility and interpretability of results by fellow investigators. Furthermore, inclusion of specific experimental details such as reagents and methods in publications would ultimately allow others to readily search the literature for these data items, especially given the ongoing trend towards open access full text journals.

  15. Probing hybridization parameters from microarray experiments: nearest-neighbor model and beyond

    PubMed Central

    Hadiwikarta, W. W.; Walter, J.-C.; Hooyberghs, J.; Carlon, E.

    2012-01-01

    In this article, it is shown how optimized and dedicated microarray experiments can be used to study the thermodynamics of DNA hybridization for a large number of different conformations in a highly parallel fashion. In particular, free energy penalties for mismatches are obtained in two independent ways and are shown to be correlated with values from melting experiments in solution reported in the literature. The additivity principle, which is at the basis of the nearest-neighbor model, and according to which the penalty for two isolated mismatches is equal to the sum of the independent penalties, is thoroughly tested. Additivity is shown to break down for a mismatch distance below 5 nt. The behavior of mismatches in the vicinity of the helix edges, and the behavior of tandem mismatches are also investigated. Finally, some thermodynamic outlying sequences are observed and highlighted. These sequences contain combinations of GA mismatches. The analysis of the microarray data reported in this article provides new insights on the DNA hybridization parameters and can help to increase the accuracy of hybridization-based technologies. PMID:22661582

  16. Evaluation of the Teledyne SIDECAR ASIC at cryogenic temperature using a visible hybrid H2RG focal plane array in 32 channel readout mode

    NASA Astrophysics Data System (ADS)

    Dorn, Reinhold J.; Eschbaumer, Siegfried; Hall, Donald N. B.; Finger, Gert; Mehrgan, Leander; Meyer, Manfred; Stegmeier, Joerg

    2008-07-01

    Teledyne Imaging Sensors (TIS) has developed a new CMOS device known as the SIDECAR application-specific integrated circuit (ASIC). This single chip provides all the functionality of FPA drive electronics to operate visible and infrared imaging detectors with a fully digital interface. At the last SPIE conference we presented test and performance results of a Teledyne 2K×2K silicon PIN diode array hybridized to a Hawaii-2RG multiplexer, the Hybrid Visible Silicon Imager (HyViSI). This detector was read out with the ESO standard IR detector controller IRACE, which delivers detector limited performance. We have now tested the H2RG HyViSI detector with the new TIS SIDECAR ASIC in 32 channel readout mode at cryogenic temperatures. The SIDECAR has been evaluated down to 105 Kelvin operating temperature and performance results have been compared to those obtained with external electronics. We find that the SIDECAR ASIC provides performance equal to optimized external electronics.

  17. Three clinical experiences with SNP array results consistent with parental incest: a narrative with lessons learned.

    PubMed

    Helm, Benjamin M; Langley, Katherine; Spangler, Brooke; Vergano, Samantha

    2014-08-01

    Single nucleotide polymorphism microarrays have the ability to reveal parental consanguinity which may or may not be known to healthcare providers. Consanguinity can have significant implications for the health of patients and for individual and family psychosocial well-being. These results often present ethical and legal dilemmas that can have important ramifications. Unexpected consanguinity can be confounding to healthcare professionals who may be unprepared to handle these results or to communicate them to families or other appropriate representatives. There are few published accounts of experiences with consanguinity and SNP arrays. In this paper we discuss three cases where molecular evidence of parental incest was identified by SNP microarray. We hope to further highlight consanguinity as a potential incidental finding, how the cases were handled by the clinical team, and what resources were found to be most helpful. This paper aims to contribute further to professional discourse on incidental findings with genomic technology and how they were addressed clinically. These experiences may provide some guidance on how others can prepare for these findings and help improve practice. As genetic and genomic testing is utilized more by non-genetics providers, we also hope to inform about the importance of engaging with geneticists and genetic counselors when addressing these findings. PMID:24222483

  18. Development of 90 kgf Class CAMUI Hybrid Rocket for a CanSat Experiment

    NASA Astrophysics Data System (ADS)

    Nagata, Harunori; Uematsu, Tsutomu; Ito, Mitsunori; Kakikura, Akihito; Kaneko, Yudai; Mori, Kazuhiro; Murai, Norikazu; Sato, Tatsuhiro; Mitsuhashi, Ryuichi; Totani, Tsuyoshi

    A newly designed CAMUI hybrid rocket motor of 900 N (90 kgf) thrust class, CAMUI-90, was developed. It uses a combination of polyethylene and liquid oxygen as propellants. CAMUI hybrid rocket is an explosive-flee small rocket motor to realize a small launch system with low cost and flexibility. The motor produces a thrust of 900 N for four seconds, keeping the optimal characteristic exhaust velocity of the fuel-oxidizer combination (exceeding 1800 m/s). A main application of the CAMUI-90 motor is for a CanSat experiment. A launch vehicle employing CAMUI-90 motor, 120 mm in diameter and 3.05 m in length, accelerates a payload of 500 g to 140 m/s in four seconds and reaches to an altitude of about 1 km. The first launch of this vehicle was on December 2006.

  19. Practical guide for implementing hybrid PET/MR clinical service: lessons learned from our experience.

    PubMed

    Parikh, Nainesh; Friedman, Kent P; Shah, Shetal N; Chandarana, Hersh

    2015-08-01

    Positron emission tomography (PET) and magnetic resonance imaging, until recently, have been performed on separate PET and MR systems with varying temporal delay between the two acquisitions. The interpretation of these two separately acquired studies requires cognitive fusion by radiologists/nuclear medicine physicians or dedicated and challenging post-processing. Recent advances in hardware and software with introduction of hybrid PET/MR systems have made it possible to acquire the PET and MR images simultaneously or near simultaneously. This review article serves as a road-map for clinical implementation of hybrid PET/MR systems and briefly discusses hardware systems, the personnel needs, safety and quality issues, and reimbursement topics based on experience at NYU Langone Medical Center and Cleveland Clinic. PMID:25985966

  20. Practical guide for implementing hybrid PET/MR clinical service: lessons learned from our experience

    PubMed Central

    Parikh, Nainesh; Friedman, Kent P.; Shah, Shetal N.; Chandarana, Hersh

    2015-01-01

    Positron emission tomography (PET) and magnetic resonance imaging, until recently, have been performed on separate PET and MR systems with varying temporal delay between the two acquisitions. The interpretation of these two separately acquired studies requires cognitive fusion by radiologists/nuclear medicine physicians or dedicated and challenging post-processing. Recent advances in hardware and software with introduction of hybrid PET/MR systems have made it possible to acquire the PET and MR images simultaneously or near simultaneously. This review article serves as a road-map for clinical implementation of hybrid PET/MR systems and briefly discusses hardware systems, the personnel needs, safety and quality issues, and reimbursement topics based on experience at NYU Langone Medical Center and Cleveland Clinic. PMID:25985966

  1. Analyses of Genotypes and Phenotypes of Ten Chinese Patients with Wolf-Hirschhorn Syndrome by Multiplex Ligation-dependent Probe Amplification and Array Comparative Genomic Hybridization

    PubMed Central

    Yang, Wen-Xu; Pan, Hong; Li, Lin; Wu, Hai-Rong; Wang, Song-Tao; Bao, Xin-Hua; Jiang, Yu-Wu; Qi, Yu

    2016-01-01

    Background: Wolf-Hirschhorn syndrome (WHS) is a contiguous gene syndrome that is typically caused by a deletion of the distal portion of the short arm of chromosome 4. However, there are few reports about the features of Chinese WHS patients. This study aimed to characterize the clinical and molecular cytogenetic features of Chinese WHS patients using the combination of multiplex ligation-dependent probe amplification (MLPA) and array comparative genomic hybridization (array CGH). Methods: Clinical information was collected from ten patients with WHS. Genomic DNA was extracted from the peripheral blood of the patients. The deletions were analyzed by MLPA and array CGH. Results: All patients exhibited the core clinical symptoms of WHS, including severe growth delay, a Greek warrior helmet facial appearance, differing degrees of intellectual disability, and epilepsy or electroencephalogram anomalies. The 4p deletions ranged from 2.62 Mb to 17.25 Mb in size and included LETM1, WHSC1, and FGFR3. Conclusions: The combined use of MLPA and array CGH is an effective and specific means to diagnose WHS and allows for the precise identification of the breakpoints and sizes of deletions. The deletion of genes in the WHS candidate region is closely correlated with the core WHS phenotype. PMID:26960370

  2. Ni foam supported three-dimensional vertically aligned and networked layered CoO nanosheet/graphene hybrid array as a high-performance oxygen evolution electrode

    NASA Astrophysics Data System (ADS)

    Yuan, Weiyong; Zhao, Ming; Yuan, Jia; Li, Chang Ming

    2016-07-01

    The sluggish oxygen evolution reaction (OER) represents a major kinetic bottleneck in water splitting. Herein we report the synthesis of a novel Ni foam (NF) supported 3-D vertically aligned and interconnected layered CoO nanosheet array with controlled density, layer thickness, and interlayer spacing, and the conformal self-assembly of graphene on this nanosheet array. The obtained CoO layered nanosheet/graphene hybrid nanoarray was directly used as an OER electrode, showing a current density of 10 mA cm-2 at an overpotential of 330 mV and a Tafel slope of 79 mV dec-1, both of which are much lower than pristine NF and the nanosheet array without graphene, and are among the lowest reported for Co-based OER catalysts and transition metal oxide-based ones measured under the same conditions. In addition, it can retain 92.4% of the current density after 66 h of chronoamperometry testing at a potential of 1.0 V vs. SCE, and 94.3% of the current density at 1.0 V vs. SCE after 200 cyclic voltammetry cycles (0-1.0 V vs. SCE). The excellent catalytic activity and stability toward OER are ascribed to the 3-D NF supported robustly grown networked layered nanosheet array structure and the synergistic effects between CoO layered nanosheets and graphene.

  3. Wire array experiments in a low impedance and low current generator

    NASA Astrophysics Data System (ADS)

    Cabrini, Nibaldo; Pavez, Cristian; Avaria, Gonzalo; San Martin, Patricio; Veloso, Felipe; Zúñiga, Barbara; Sepúlveda, Adolfo; Soto, Leopoldo

    2015-03-01

    In this work, a preliminary study about the behavior of a low impedance generator on different wire array configurations is reported. The experimental measurements were carried out on a small multi-purpose generator (1.2μF, 345J, 47.5nH, T/4 = 375 ns and Z = 0.2Ω in short circuit) which produces currents up to 122 kA with 500 ns quarter period, when a charging voltage of 24kV and a wire load are used. Two types of configurations were tested: parallel wires (two and four) and X-pinch configurations. The experiments were carried out on W, Al, and Cu wires with different diameters. The discharge was characterized by means of a set of diagnostics which included: Rogowski coil; filtered PCD detector; filtered PIN diode; gated VUV/soft X-ray pinhole camera, Shadow diagnostic and dark field Schlieren technique. From the set of experimental results, the following observations can be established: (i) The generator is highly sensitive to the changes of load impedance due to its low impedance design. (ii) Every shot shows a dip in the current derivative signal shortly after the discharge onset time (from 6 to 40 ns), which is inversely related to the load resistance. (iii) Both configurations show a similar dynamic to those observed in experiments of higher current and shorter quarter period. (iv) At the X-pinch experiments, two or more hard X-ray bursts are detected, around 200 ns from the current onset time. These X-ray bursts are correlated with the dips observed in the current derivative signal.

  4. Design and initial operation of a two-color soft x-ray camera system on the Compact Toroidal Hybrid experiment

    SciTech Connect

    Herfindal, J. L. Dawson, J. D.; Ennis, D. A.; Hartwell, G. J.; Loch, S. D.; Maurer, D. A.

    2014-11-15

    A multi-camera soft x-ray diagnostic has been developed to measure the equilibrium electron temperature profile and temperature fluctuations due to magnetohydrodynamic activity on the Compact Toroidal Hybrid experiment. The diagnostic consists of three separate cameras each employing two 20-channel diode arrays that view the same plasma region through different beryllium filter thicknesses of 1.8 μm and 3.0 μm allowing electron temperature measurements between 50 eV and 200 eV. The Compact Toroidal Hybrid is a five-field period current-carrying stellarator, in which the presence of plasma current strongly modifies the rotational transform and degree of asymmetry of the equilibrium. Details of the soft x-ray emission, effects of plasma asymmetry, and impurity line radiation on the design and measurement of the two-color diagnostic are discussed. Preliminary estimates of the temperature perturbation due to sawtooth oscillations observed in these hybrid discharges are given.

  5. Novel Hamamatsu Multi-Pixel Photon Counter (MPPC) array studies for the GlueX experiment: New results

    NASA Astrophysics Data System (ADS)

    Soto, Orlando; Rojas, Rimsky; Kuleshov, Sergey; Hakobyan, Hayk; Toro, Alam; Brooks, William K.; Rios, Rene

    2014-03-01

    The novel Hamamatsu Multi-Pixel Photon Counter (MPPC) S12045(X) is an array of 16 individual 3×3 mm2 MPPC devices each with 3600 Geiger-mode Avalanche Photodiode pixels of 50×50 μm2. Each MPPC in the array operates at a reverse bias of approximately 70 V. This paper summarizes our characterization of MPPC arrays used in the GlueX experiment in Hall D at Thomas Jefferson National Accelerator Facility (Jefferson Lab). We studied the main features of each of the 16 MPPC array channels for 2800 MPPC arrays at several different temperatures. Two measurement stations were built to extract gain, breakdown voltage, photon detection efficiency, optical crosstalk and dark rate for each of the 44 800 MPPC array channels at each temperature setting. The hardware and the data analysis are described, and new analytical expressions for the mean number of photoelectrons and optical crosstalk are presented, as well as systematic trends of the performance parameters.

  6. The design of microstrip dipole arrays including mutual coupling. I Theory. II - Experiment

    NASA Astrophysics Data System (ADS)

    Elliott, R. S.; Stern, G. J.

    1981-09-01

    A design technique which includes mutual coupling is formulated for use with microstrip dipole arrays. The technique is based on iterative solution of a combined design equation and requires as input foreknowledge of the self-impedances and mutual impedances of microstrip dipoles and also the link between the radiating current and the backscattered wave in the feeding line. Procedures for obtaining the input design data for microstrip dipole arrays are then described and the design of a typical array is presented. The design data indicate that mutual coupling is a significant factor which cannot be ignored in the design of small microstrip dipole arrays.

  7. Lower hybrid experiments on PLT using grills having various n/sub parallel/ spectral widths

    SciTech Connect

    Stevens, J.E.; Bell, R.; Bernabei, S.; Cavallo, A.; Chu, T.K.; Colestock, P.; Hooke, W.; Hosea, J.; Jobes, F.; Luce, T.

    1987-05-01

    Coupling structures for lower hybrid current drive experiments have, until now, been smaller than a free space wavelength and have had a correspondingly broad wave number spectrum. In this paper we report the results of experiments on the PLT tokamak using a 16-waveguide grill (2.2 wavelengths) which produces a very narrow n/sub parallel/ = k/sub parallel/c/..omega.. spectrum. Experimental results from the 16-waveguide grill are compared with results from three other PLT grills with less sharply defined n/sub parallel/ spectra. The current drive figure of merit, I/sub p/n/sub e/R/P/sub rf/ approx. =0.14 x 10/sup 14/ A cm/sup -3/ m/W, is approx. =40% higher for the 16-waveguide coupler than for previously reported experiments on PLT, in spite of the larger ''spectral gap.'' 60 refs.

  8. Minimum Information Specification For In Situ Hybridization and Immunohistochemistry Experiments (MISFISHIE)

    SciTech Connect

    Deutsch, Eric W.; Ball, Cathy; Berman, Jules J.; Bova, G. S.; Brazma, Alvis; Bumgarner, Roger E.; Campbell, David; Causton, Helen C.; Christiansen, Jeff; Daian, Fabrice; Dauga, Delphine; Davidson, Duncan; Gimenez, Gregory; Goo, Young Ah; Grimmond, Sean; Henrich, Thorsten; Herrmann, Bernhard G.; Johnson, Michael H.; Korb, Martin; Mills, Jason C.; Oudes, Asa; Parkinson, Helen E.; Pascal, Laura E.; Pollet, Nicolas; Quackenbush, John; Ramialison, Mirana; Ringwald, Martin; Salgado, David; Sansone, Susanna A.; Sherlock, Gavin; Stoeckert, Christian Jr. J.; Swedlow, Jason; Taylor, Ronald C.; Walashek, Laura; Warford, Anthony; Wilkinson, David G.; Zhou, Yi; Zon, Leonard I.; Liu, Alvin Y.; True, Lawrence D.

    2008-03-03

    We describe the creation process of the Minimum Information Specification For In Situ Hybridization and Immunohistochemistry Experiments (MISFISHIE). Modeled after the existing minimum information specification for microarray data, we created a new specification for gene expression localization experiments, initially to facilitate data sharing within a consortium. After successful use within the consortium, the specification was circulated to members of the wider biomedical research community for comment and refinement. After a period of acquiring many new suggested requirements, it was necessary to enter a final phase of excluding those requirements that were deemed inappropriate as a minimum requirement for all experiments. The full specification will soon be published as a version 1.0 proposal to the community, upon which a more full discussion must take place so that the final specification may be achieved with the involvement of the whole community.

  9. The hybrid mesons quest: the MesonEx experiment at Jefferson Laboratory

    NASA Astrophysics Data System (ADS)

    Rizzo, A.; CLAS Collaboration

    2016-02-01

    The meson spectroscopy plays nowadays a central role in the investigation of hadron structure thanks to the possible existence of exotic hybrid mesons, quark-antiquark-gluon bound states. Their explicit gluonic degrees of freedom which should clearly emerge from a Partial Wave Analysis (PWA) of the corresponding Dalitz plot of the exotic particle decay, may result in final JPC configurations not allowed in the constituent quark model. Besides this clear signature, hybrid mesons are also expected to have a large particle multiplicity decays, requiring for their search an experimental apparatus with high performances in terms of rate capability, resolution and almost a full acceptance to apply PWA methods. New-generation experiments are planned at Thomas Jefferson National Laboratory (VA, USA) for which an unprecedented statistics of large multiplicity decay events with fully reconstructed kinematics will be available. In particular for the MesonEx (CLAS12) experiment in Hall B, a wide scientific program that will start in 2016 has been deployed to study the meson spectrum at energies up to 11 GeV. A key role in such program is played by the Forward Tagger apparatus of the experiment, which will allow to extend the study of meson electro-production to very low Q2 values, in a quasi-real photo production kinematical region, where the production of hybrid mesons is expected to be favorite. Currently a new analysis framework for the search of the hybrid mesons is being set up by the HASPECT network, an international structure which gather people involved into theoretical and experimental hadronic physics all over the world. The goals of the network is to develop new analysis models and statistical techniques to unfold the signal and background distributions in high-statistics datasets. In this work are briefly presented the first preliminary results from the application of a statistical technique, namely the sPlot, to the data already acquired by the CLAS experiment for

  10. Progress of Integral Experiments in Benchmark Fission Assemblies for a Blanket of Hybrid Reactor

    NASA Astrophysics Data System (ADS)

    Liu, R.; Zhu, T. H.; Yan, X. S.; Lu, X. X.; Jiang, L.; Wang, M.; Han, Z. J.; Wen, Z. W.; Lin, J. F.; Yang, Y. W.

    2014-04-01

    This article describes recent progress in integral neutronics experiments in benchmark fission assemblies for the blanket design in a hybrid reactor. The spherical assemblies consist of three layers of depleted uranium shells and several layers of polyethylene shells, separately. In the assemblies with centralizing the D-T neutron source, the plutonium production rates, uranium fission rates and leakage neutron spectra are measured. The measured results are compared to the calculated ones with the MCNP-4B code and ENDF/B-VI library data, available.

  11. All-solid-state hybrid solar cells based on a new organometal halide perovskite sensitizer and one-dimensional TiO2 nanowire arrays

    NASA Astrophysics Data System (ADS)

    Qiu, Jianhang; Qiu, Yongcai; Yan, Keyou; Zhong, Min; Mu, Cheng; Yan, He; Yang, Shihe

    2013-03-01

    A novel organometal halide perovskite (CH3NH3PbI2Br) is synthesized and used as a visible light absorber to sensitize one-dimensional (1D) TiO2 nanowire arrays (NWAs) for all-solid-state hybrid solar cells. It achieved a power conversion efficiency (PCE) of 4.87% and an open circuit voltage (Voc) of 0.82 V, both higher than those of its analogue CH3NH3PbI3.A novel organometal halide perovskite (CH3NH3PbI2Br) is synthesized and used as a visible light absorber to sensitize one-dimensional (1D) TiO2 nanowire arrays (NWAs) for all-solid-state hybrid solar cells. It achieved a power conversion efficiency (PCE) of 4.87% and an open circuit voltage (Voc) of 0.82 V, both higher than those of its analogue CH3NH3PbI3. Electronic supplementary information (ESI) available: Experimental procedures, characterization details, including additional SEM, TEM, EDS, XRD and photovoltaic characteristics of cells based on TiO2 NWAs with different film thickness. See DOI: 10.1039/c3nr00218g

  12. Performance of the solid state neutral particle analyzer array on the national spherical torus experiment

    SciTech Connect

    Liu, D.; Heidbrink, W. W.; Darrow, D. S.; Roquemore, A. L.; Medley, S. S.; Shinohara, K.

    2006-10-15

    The solid state neutral particle analyzer (SSNPA) array on the national spherical torus experiment (NSTX) consists of four chords with tangency radii of 60, 90, 100, and 120 cm that view across the three coinjection neutral beam lines. Each chord utilizes a silicon photodiode that is coupled to fast digitizers to measure the energy distribution of charge exchange fast neutral particles (30-100 keV). By the end of the NSTX 2005 experimental campaign, the electromagnetic noise in the SSNPA was reduced by half and reasonable signals were obtained with good electromagnetic shielding, fast digitization of raw signals, software-based pulse height analysis, and pulse shape discrimination. Energy resolution of {approx}10 keV and time resolution of 2 ms have been achieved. Temporal evolutions of energetic neutral flux obtained with the SSNPA are in good agreement with those obtained with the E(parallel sign)B-type neutral particle analyzer. With these improvements, the SSNPA can be used to study magnetohydrodynamic instabilities and fast ion redistribution. Example data from plasma discharges are presented along with the noise reduction techniques and postshot pulse height analysis methods.

  13. Genomic Alteration in Head and Neck Squamous Cell Carcinoma (HNSCC) Cell Lines Inferred from Karyotyping, Molecular Cytogenetics, and Array Comparative Genomic Hybridization.

    PubMed

    Singchat, Worapong; Hitakomate, Ekarat; Rerkarmnuaychoke, Budsaba; Suntronpong, Aorarat; Fu, Beiyuan; Bodhisuwan, Winai; Peyachoknagul, Surin; Yang, Fengtang; Koontongkaew, Sittichai; Srikulnath, Kornsorn

    2016-01-01

    Genomic alteration in head and neck squamous cell carcinoma (HNSCC) was studied in two cell line pairs (HN30-HN31 and HN4-HN12) using conventional C-banding, multiplex fluorescence in situ hybridization (M-FISH), and array comparative genomic hybridization (array CGH). HN30 and HN4 were derived from primary lesions in the pharynx and base of tongue, respectively, and HN31 and HN12 were derived from lymph-node metastatic lesions belonging to the same patients. Gain of chromosome 1, 7, and 11 were shared in almost all cell lines. Hierarchical clustering revealed that HN31 was closely related to HN4, which shared eight chromosome alteration cases. Large C-positive heterochromatins were found in the centromeric region of chromosome 9 in HN31 and HN4, which suggests complex structural amplification of the repetitive sequence. Array CGH revealed amplification of 7p22.3p11.2, 8q11.23q12.1, and 14q32.33 in all cell lines involved with tumorigenesis and inflammation genes. The amplification of 2p21 (SIX3), 11p15.5 (H19), and 11q21q22.3 (MAML2, PGR, TRPC6, and MMP family) regions, and deletion of 9p23 (PTPRD) and 16q23.1 (WWOX) regions were identified in HN31 and HN12. Interestingly, partial loss of PTPRD (9p23) and WWOX (16q23.1) genes was identified in HN31 and HN12, and the level of gene expression tended to be the down-regulation of PTPRD, with no detectable expression of the WWOX gene. This suggests that the scarcity of PTPRD and WWOX genes might have played an important role in progression of HNSCC, and could be considered as a target for cancer therapy or a biomarker in molecular pathology. PMID:27501229

  14. Genomic Alteration in Head and Neck Squamous Cell Carcinoma (HNSCC) Cell Lines Inferred from Karyotyping, Molecular Cytogenetics, and Array Comparative Genomic Hybridization

    PubMed Central

    Rerkarmnuaychoke, Budsaba; Suntronpong, Aorarat; Fu, Beiyuan; Bodhisuwan, Winai; Peyachoknagul, Surin; Yang, Fengtang; Koontongkaew, Sittichai; Srikulnath, Kornsorn

    2016-01-01

    Genomic alteration in head and neck squamous cell carcinoma (HNSCC) was studied in two cell line pairs (HN30-HN31 and HN4-HN12) using conventional C-banding, multiplex fluorescence in situ hybridization (M-FISH), and array comparative genomic hybridization (array CGH). HN30 and HN4 were derived from primary lesions in the pharynx and base of tongue, respectively, and HN31 and HN12 were derived from lymph-node metastatic lesions belonging to the same patients. Gain of chromosome 1, 7, and 11 were shared in almost all cell lines. Hierarchical clustering revealed that HN31 was closely related to HN4, which shared eight chromosome alteration cases. Large C-positive heterochromatins were found in the centromeric region of chromosome 9 in HN31 and HN4, which suggests complex structural amplification of the repetitive sequence. Array CGH revealed amplification of 7p22.3p11.2, 8q11.23q12.1, and 14q32.33 in all cell lines involved with tumorigenesis and inflammation genes. The amplification of 2p21 (SIX3), 11p15.5 (H19), and 11q21q22.3 (MAML2, PGR, TRPC6, and MMP family) regions, and deletion of 9p23 (PTPRD) and 16q23.1 (WWOX) regions were identified in HN31 and HN12. Interestingly, partial loss of PTPRD (9p23) and WWOX (16q23.1) genes was identified in HN31 and HN12, and the level of gene expression tended to be the down-regulation of PTPRD, with no detectable expression of the WWOX gene. This suggests that the scarcity of PTPRD and WWOX genes might have played an important role in progression of HNSCC, and could be considered as a target for cancer therapy or a biomarker in molecular pathology. PMID:27501229

  15. 3D TiO2@Ni(OH)2 Core-shell Arrays with Tunable Nanostructure for Hybrid Supercapacitor Application

    PubMed Central

    Ke, Qingqing; Zheng, Minrui; Liu, Huajun; Guan, Cao; Mao, Lu; Wang, John

    2015-01-01

    Three dimensional hierarchical nanostructures have attracted great attention for electrochemical energy storage applications. In this work, self-supported TiO2@Ni(OH)2 core-shell nanowire arrays are prepared on carbon fiber paper via the combination of hydrothermal synthesis and chemical bath deposition. In this core-shell hybrid, the morphology and wall size of the interconnected nanoflake shell of Ni(OH)2 can be tuned through adjusting the concentration of ammonia solution. Heterogeneous nucleation and subsequent oriented crystal growth are identified to be the synthesis mechanism affecting the nanostructure of the shell material, which consequently determines the electrochemical performance in both energy storage and charge transfer. Superior capabilities of 264 mAhg−1 at 1 A g−1 and 178 mAh g−1 at 10 A g−1 are achieved with the core-shell hybrids of the optimized structure. The asymmetric supercapacitor prototype, comprising of TiO2@Ni(OH)2 as the anode and mesoporous carbons (MCs) as the cathode, is shown to exhibit superior electrochemical performance with high energy and power densities. The present work provides a clear illustration of the structure-property relationship in nanocrystal synthesis and offers a potential strategy to enhance the battery type Ni(OH)2 electrode in a hybrid supercapacitor device. PMID:26353970

  16. 3D TiO2@Ni(OH)2 Core-shell Arrays with Tunable Nanostructure for Hybrid Supercapacitor Application

    NASA Astrophysics Data System (ADS)

    Ke, Qingqing; Zheng, Minrui; Liu, Huajun; Guan, Cao; Mao, Lu; Wang, John

    2015-09-01

    Three dimensional hierarchical nanostructures have attracted great attention for electrochemical energy storage applications. In this work, self-supported TiO2@Ni(OH)2 core-shell nanowire arrays are prepared on carbon fiber paper via the combination of hydrothermal synthesis and chemical bath deposition. In this core-shell hybrid, the morphology and wall size of the interconnected nanoflake shell of Ni(OH)2 can be tuned through adjusting the concentration of ammonia solution. Heterogeneous nucleation and subsequent oriented crystal growth are identified to be the synthesis mechanism affecting the nanostructure of the shell material, which consequently determines the electrochemical performance in both energy storage and charge transfer. Superior capabilities of 264 mAhg-1 at 1 A g-1 and 178 mAh g-1 at 10 A g-1 are achieved with the core-shell hybrids of the optimized structure. The asymmetric supercapacitor prototype, comprising of TiO2@Ni(OH)2 as the anode and mesoporous carbons (MCs) as the cathode, is shown to exhibit superior electrochemical performance with high energy and power densities. The present work provides a clear illustration of the structure-property relationship in nanocrystal synthesis and offers a potential strategy to enhance the battery type Ni(OH)2 electrode in a hybrid supercapacitor device.

  17. 3D TiO2@Ni(OH)2 Core-shell Arrays with Tunable Nanostructure for Hybrid Supercapacitor Application.

    PubMed

    Ke, Qingqing; Zheng, Minrui; Liu, Huajun; Guan, Cao; Mao, Lu; Wang, John

    2015-01-01

    Three dimensional hierarchical nanostructures have attracted great attention for electrochemical energy storage applications. In this work, self-supported TiO2@Ni(OH)2 core-shell nanowire arrays are prepared on carbon fiber paper via the combination of hydrothermal synthesis and chemical bath deposition. In this core-shell hybrid, the morphology and wall size of the interconnected nanoflake shell of Ni(OH)2 can be tuned through adjusting the concentration of ammonia solution. Heterogeneous nucleation and subsequent oriented crystal growth are identified to be the synthesis mechanism affecting the nanostructure of the shell material, which consequently determines the electrochemical performance in both energy storage and charge transfer. Superior capabilities of 264 mAh g(-1) at 1 A g(-1) and 178 mAh g(-1) at 10 A g(-1) are achieved with the core-shell hybrids of the optimized structure. The asymmetric supercapacitor prototype, comprising of TiO2@Ni(OH)2 as the anode and mesoporous carbons (MCs) as the cathode, is shown to exhibit superior electrochemical performance with high energy and power densities. The present work provides a clear illustration of the structure-property relationship in nanocrystal synthesis and offers a potential strategy to enhance the battery type Ni(OH)2 electrode in a hybrid supercapacitor device. PMID:26353970

  18. Prototype studies on the forward MWDC tracking array of the external target experiment at HIRFL-CSR

    NASA Astrophysics Data System (ADS)

    Yi, Han; Zhang, Zhao; Xiao, Zhi-Gang; Cheng, Wen-Jing; Lü, Li-Ming; Yan, Wei-Hua; Wang, Ren-Sheng; Li, Hong-Jie; Huang, Yan; Zhang, Yan; Duan, Li-Min; Hu, Rong-Jiang; Lu, Chen-Gui; Yang, He-Run; Ma, Peng

    2014-12-01

    A prototype of the forward tracking array consisting of three multiwire drift chambers (MWDC) for the external target experiment (CEE) at the Heavy Ion Research Facility at the Lanzhou -Cooling Storage Ring (HIRFL-CSR) has been assembled and tested using cosmic rays. The signals from the anode wires are amplified and fed to a Flash-ADC to deliver the drift time and charge integration. The performances of the array prototype are investigated under various high voltages. For the tracking performances, after the space-time relation (STR) calibration and the detector displacement correction, the standard deviation of 223 μm of the residue is obtained. The performances of the forward MWDCs tracking array meets the requirements of CEE in design.

  19. Facile construction of vertically aligned EuS-ZnO hybrid core shell nanorod arrays for visible light driven photocatalytic properties

    SciTech Connect

    Ranjith, K. S.; Kumar, D. Ranjith; Kumar, R. T. Rajendra

    2015-06-24

    We demonstrated the development of coupled semiconductor in the form of hybrid heterostructures for significant advancement in catalytic functional materials. In this article, we report the preparation of vertically aligned core shell ZnO-EuS nanorod photocatalyst arrays by a simple chemical solution process followed by sulfudation process. The XRD pattern confirmed formation of the hexagonal wurtzite structure of ZnO and cubic nature of the EuS. Cross sectional FESEM images show vertical rod array structure, and the size of the nanorods ranges from 80 to 120 nm. UV-Vis DRS spectra showed that the optical absorption of ZnO was significantly enhanced to the visible region by modification with EuS surfaces. TEM study confirmed that the surface of ZnO was drastically improved by the modification with EuS nanoparticle. The catalytic activity of EuS−ZnO core shell nanorod arrays were evaluated by the photodegradation of Methylene Blue (MB) dye under visible irradiation. The results revealed that the photocatalytic activity of EuS−ZnO was much higher than that of ZnO under natural sunlight. EuS−ZnO was found to be stable and reusable without appreciable loss of catalytic activity up to four consecutive cycles.

  20. A genome-wide study of preferential amplification/hybridization in microarray-based pooled DNA experiments

    PubMed Central

    Yang, H.-C.; Liang, Y.-J.; Huang, M.-C.; Li, L.-H.; Lin, C.-H.; Wu, J.-Y.; Chen, Y.-T.; Fann, C.S.J.

    2006-01-01

    Microarray-based pooled DNA methods overcome the cost bottleneck of simultaneously genotyping more than 100 000 markers for numerous study individuals. The success of such methods relies on the proper adjustment of preferential amplification/hybridization to ensure accurate and reliable allele frequency estimation. We performed a hybridization-based genome-wide single nucleotide polymorphisms (SNPs) genotyping analysis to dissect preferential amplification/hybridization. The majority of SNPs had less than 2-fold signal amplification or suppression, and the lognormal distributions adequately modeled preferential amplification/hybridization across the human genome. Comparative analyses suggested that the distributions of preferential amplification/hybridization differed among genotypes and the GC content. Patterns among different ethnic populations were similar; nevertheless, there were striking differences for a small proportion of SNPs, and a slight ethnic heterogeneity was observed. To fulfill appropriate and gratuitous adjustments, databases of preferential amplification/hybridization for African Americans, Caucasians and Asians were constructed based on the Affymetrix GeneChip Human Mapping 100 K Set. The robustness of allele frequency estimation using this database was validated by a pooled DNA experiment. This study provides a genome-wide investigation of preferential amplification/hybridization and suggests guidance for the reliable use of the database. Our results constitute an objective foundation for theoretical development of preferential amplification/hybridization and provide important information for future pooled DNA analyses. PMID:16931491

  1. Validation with experiments on simplified numerical prediction of hybrid rocket internal ballistics

    NASA Astrophysics Data System (ADS)

    Funami, Yuki; Shimada, Toru

    2012-11-01

    In order to design hybrid rocket engines, we have developed a numerical prediction approach to the internal ballistics. The key point is its cost performance. Therefore simple but efficient models are required. Fluid phenomenon and thermal conduction phenomenon in a solid fuel should be treated time-dependently, because characteristic times of these phenomena are longer than those of other phenomena. Besides, they are solved with the energy-flux balance equation at the solid fuel surface to determine the regression rate. It is confirmed that numerical evaluation of time- and space-averaged regression rate is the same order of magnitude as that in experiments. However, the factors n in ṙ¯ = aG¯oxn differ between calculations and experiments.

  2. Clinical experience with array CGH: case presentations from nine months of practice.

    PubMed

    Poss, Alexis F; Goldenberg, Paula C; Rehder, Catherine W; Kearney, Hutton M; Melvin, Elizabeth C; Koeberl, Dwight D; McDonald, Marie T

    2006-10-01

    A total of 124 individuals were tested in the initial 9 months that array CGH technology was offered to clinical genetics patients. In 11 of these patients array CGH identified a previously unsuspected diagnosis. A suspected diagnosis was confirmed in three patients. A single case in this series proved to be a polymorphic copy number variant. This paper describes five of the patients with previously unsuspected diagnoses in detail. We suggest that array CGH is an improved tool ready for routine use in clinical genetics. PMID:16906557

  3. Terahertz spectroscopic polarimetry of generalized anisotropic media composed of Archimedean spiral arrays: Experiments and simulations

    NASA Astrophysics Data System (ADS)

    Aschaffenburg, Daniel J.; Williams, Michael R. C.; Schmuttenmaer, Charles A.

    2016-05-01

    Terahertz time-domain spectroscopic polarimetry has been used to measure the polarization state of all spectral components in a broadband THz pulse upon transmission through generalized anisotropic media consisting of two-dimensional arrays of lithographically defined Archimedean spirals. The technique allows a full determination of the frequency-dependent, complex-valued transmission matrix and eigenpolarizations of the spiral arrays. Measurements were made on a series of spiral array orientations. The frequency-dependent transmission matrix elements as well as the eigenpolarizations were determined, and the eigenpolarizations were found be to elliptically corotating, as expected from their symmetry. Numerical simulations are in quantitative agreement with measured spectra.

  4. Long-Term Student Experiences in a Hybrid, Open-Ended and Problem Based Adventure Learning Program

    ERIC Educational Resources Information Center

    Veletsianos, George; Doering, Aaron

    2010-01-01

    In this paper we investigate the experiences of elementary school children over a two-year period during which they engaged with a hybrid Adventure Learning program. In addition to delineating Adventure Learning experiences, we report on educational technology implementations in ecologically valid and complex environments, while drawing inferences…

  5. Experiment and Modeling of Spatially Indexed Microbead Arrays for High-Throughput Screening Applications

    NASA Astrophysics Data System (ADS)

    Leary, Thomas; Maldarelli, Charles; Couzis, Alexander

    2011-11-01

    The development of platforms for multiplexed, high throughput screening of the binding interactions of target biomolecules against a library of potential binding probes enables progress in many areas in medicine and biology. Formats in which probes are linked to microbeads arrayed in a microfluidic channel offer high sensitivity, reduced reagent consumption and are easily parallelized for multiplexed detection. This presentation describes a microfluidically assembled microbead array in which beads are streamed through a channel with an array of wells inscribed in the floor of the channel. The beads are captured in the wells via gravity. We demonstrate that an array of beads displaying different receptors can be assembled in this format, indexed by sequential depostion and used for a prototype assay. Solutions for a two dimensional mass transfer model of the conjugation of the probe to the receptor on the bead surface identify kinetically limited regimes which are used to measure the binding kinetics of the prototype assay.

  6. An OSSE study using the GFDL ensemble coupled data assimilation system: Biased twin experiment for deep Argo array

    NASA Astrophysics Data System (ADS)

    Chang, Y. S.; Zhang, S.; Rosati, A.; Vecchi, G. A.; Yang, X.

    2014-12-01

    A "biased" twin experiment of coupled data assimilation with two CGCMs is designed to address two questions: 1) given atmospheric and oceanic observations and a biased numerical climate system, how to obtain balanced climate estimation? 2) Within the steady and coherent climate estimation framework, what is the impact of deep ocean Argo profiles? Based on the modern Argo observing system and artificial extension to the full depth, "observations" drawn from one CGCM are assimilated into the other. Our results show that the simultaneous atmospheric and oceanic constraints play a significant role for preventing the deep ocean drift. Within the bias magnitude in the twin experiment, the Argo extension to the full depth does not significantly improve the quality of climate estimation. More studies based on different assimilation models with improved spatial and temporal scales of the deep Argo array are demanding for further understanding the impact of deep Argo array.

  7. Hybrid laminar flow control experiments in the NASA - Ames, 11-foot tunnel

    NASA Technical Reports Server (NTRS)

    Saric, William S.

    1995-01-01

    It was proposed to design and conduct experiments in the NASA-Ames Research Center, 11-foot wind tunnel, that would assess the role of freestream turbulence and surface roughness on swept-wing transition to turbulence. The work was to be a cooperative effort that had direct application to hybrid laminar flow control (HLFC) airfoils. The first part of the proposed work, initiated in FY92 and continued into FY93, concentrated on the design of such an experiment whose results may be compared with results obtained in other wind-tunnel facilities. At the same time, concurrent work in the Arizona State University (ASU) Unsteady Wind Tunnel would be conducted on the effects of surface roughness. The second part of the work, which was to be initiated in FY94, would have consisted of experiments conducted in both the 11-foot tunnel at NASA-Ames and the ASU Unsteady Wind Tunnel. However, this work was not continued. This report summarizes the experimental design considerations and some preliminary experiments that made up the first part of the work.

  8. Improving Health Care Coverage, Equity, And Financial Protection Through A Hybrid System: Malaysia's Experience.

    PubMed

    Rannan-Eliya, Ravindra P; Anuranga, Chamara; Manual, Adilius; Sararaks, Sondi; Jailani, Anis S; Hamid, Abdul J; Razif, Izzanie M; Tan, Ee H; Darzi, Ara

    2016-05-01

    Malaysia has made substantial progress in providing access to health care for its citizens and has been more successful than many other countries that are better known as models of universal health coverage. Malaysia's health care coverage and outcomes are now approaching levels achieved by member nations of the Organization for Economic Cooperation and Development. Malaysia's results are achieved through a mix of public services (funded by general revenues) and parallel private services (predominantly financed by out-of-pocket spending). We examined the distributional aspects of health financing and delivery and assessed financial protection in Malaysia's hybrid system. We found that this system has been effective for many decades in equalizing health care use and providing protection from financial risk, despite modest government spending. Our results also indicate that a high out-of-pocket share of total financing is not a consistent proxy for financial protection; greater attention is needed to the absolute level of out-of-pocket spending. Malaysia's hybrid health system presents continuing unresolved policy challenges, but the country's experience nonetheless provides lessons for other emerging economies that want to expand access to health care despite limited fiscal resources. PMID:27140990

  9. Experiment investigation for dynamic behavior of hybrid fiber effects on reactive powder concrete

    NASA Astrophysics Data System (ADS)

    Wang, Liwen; Pang, Baojun; Yang, Zhenqi; Chi, Runqiang

    2010-03-01

    The influences of different hybrid fibers (steel fibers add polyvinyl-alcohol fibers) mixture rates for reactive power concrete's (RPC) dynamic mechanical behavior after high temperature burnt was investigated by the Split Hopkinson pressure bar (SHPB) device. A plumbic pulse shaper technique was applied in the experiment, PVDF stress gauge was used to monitor the stress uniformity state within the specimen. The strain rate was between 75~85s-1, base on the stressstrain curves and dynamic modes of concrete specimen, the hybrid fiber effect on the dynamic properties was determined. The results show, dynamic compression strength of specimens which mixed with steel fibers (1.0%,1.5%,2.0% vol. rate) and 0.1% PVA fibers is higher than normal reactive powder concrete (NRPC), but the toughness improves unconspicuous; while strength of the one which has both steel fiber (1.0%,1.5%,2.0% vol. rate) and 0.2%PVA fiber declines than NRPC but the toughness improves and the plastic behaviors strengthened, stress-strain curve has evident rising and plate portions. It can be deduced that the concrete with mixed two kinds of fibers has improved dynamic mechanical properties after high temperature burnt. By compounding previous literature results, the mechanism of the experimental results can be explained.

  10. Experiment investigation for dynamic behavior of hybrid fiber effects on reactive powder concrete

    NASA Astrophysics Data System (ADS)

    Wang, Liwen; Pang, Baojun; Yang, Zhenqi; Chi, Runqiang

    2009-12-01

    The influences of different hybrid fibers (steel fibers add polyvinyl-alcohol fibers) mixture rates for reactive power concrete's (RPC) dynamic mechanical behavior after high temperature burnt was investigated by the Split Hopkinson pressure bar (SHPB) device. A plumbic pulse shaper technique was applied in the experiment, PVDF stress gauge was used to monitor the stress uniformity state within the specimen. The strain rate was between 75~85s-1, base on the stressstrain curves and dynamic modes of concrete specimen, the hybrid fiber effect on the dynamic properties was determined. The results show, dynamic compression strength of specimens which mixed with steel fibers (1.0%,1.5%,2.0% vol. rate) and 0.1% PVA fibers is higher than normal reactive powder concrete (NRPC), but the toughness improves unconspicuous; while strength of the one which has both steel fiber (1.0%,1.5%,2.0% vol. rate) and 0.2%PVA fiber declines than NRPC but the toughness improves and the plastic behaviors strengthened, stress-strain curve has evident rising and plate portions. It can be deduced that the concrete with mixed two kinds of fibers has improved dynamic mechanical properties after high temperature burnt. By compounding previous literature results, the mechanism of the experimental results can be explained.

  11. Performance of hybrids between weedy rice and insect-resistant transgenic rice under field experiments: implication for environmental biosafety assessment.

    PubMed

    Cao, Qian-Jin; Xia, Hui; Yang, Xiao; Lu, Bao-Rong

    2009-12-01

    Transgene escape from genetically modified (GM) rice into weedy rice via gene flow may cause undesired environmental consequences. Estimating the field performance of crop-weed hybrids will facilitate our understanding of potential introgression of crop genes (including transgenes) into weedy rice populations, allowing for effective biosafety assessment. Comparative studies of three weedy rice strains and their hybrids with two GM rice lines containing different insect-resistance transgenes (CpTI or Bt/CpTI) indicated an enhanced relative performance of the crop-weed hybrids, with taller plants, more tillers, panicles, and spikelets per plant, as well as higher 1 000-seed weight, compared with the weedy rice parents, although the hybrids produced less filled seeds per plant than their weedy parents. Seeds from the F(1) hybrids had higher germination rates and produced more seedlings than the weedy parents, which correlated positively with 1 000-seed weight. The crop-weed hybrids demonstrated a generally enhanced relative performance than their weedy rice parents in our field experiments. These findings indicate that transgenes from GM rice can persist to and introgress into weedy rice populations through recurrent crop-to-weed gene flow with the aid of slightly increased relative fitness in F(1) hybrids. PMID:20021561

  12. Targeted hyperthermia in prostate with an MR-guided endorectal ultrasound phased array: patient specific modeling and preliminary experiments

    NASA Astrophysics Data System (ADS)

    Salgaonkar, Vasant A.; Prakash, Punit; Plata, Juan; Holbrook, Andrew; Rieke, Viola; Kurhanewicz, John; Hsu, I.-C.; Diederich, Chris J.

    2013-02-01

    Feasibility of hyperthermia delivery to the prostate with a commercially available MR-guided endorectal ultrasound (ERUS) phased array ablation system (ExAblate 2100, Insightec, LTD) was assessed through computer simulations and ex vivo experiments. The simulations included a 3D FEM-based biothermal model, and acoustic field calculations for the ExAblate phased array (2.3 MHz, 2.3x4.0 cm2) using the rectangular radiator method. Array beamforming strategies were investigated to deliver 30-min hyperthermia (<41 °C) to focal regions of prostate cancer, identified from MR images in representative patient cases. Constraints on power densities, sonication durations and switching speeds imposed by ExAblate hardware and software were incorporated in the models. T<41 °C was calculated in 14-19 cm3 for sonications with planar or diverging beam patterns at 0.9-1.2 W/cm2, and in 3-10 cm3 for curvilinear (cylindrical) or multifocus beam patterns at 1.5-3.3 W/cm2, potentially useful for treating focal disease in a single posterior quadrant. Preliminary experiments included beamformed sonications in tissue mimicking phantom material under MRI-based temperature monitoring at 3T (GRE TE=7.0 ms, TR=15 ms, BW=10.5 kHz, FOV=15 cm, matrix 128x128, FA=40°). MR-temperature rises of 2-6 °C were induced in a phantom with the ExAblate array, consistent with calculated values and lower power settings (~0.86 W/cm2, 3 min.). Conformable hyperthermia may be delivered by tailoring power deposition along the array length and angular expanse. MRgERUS HIFU systems can be controlled for continuous hyperthermia in prostate to augment radiotherapy and drug delivery. [FUS Foundation, NIH R01 122276, 111981].

  13. Isotopic effect in experiments on lower hybrid current drive in the FT-2 tokamak

    SciTech Connect

    Lashkul, S. I. Altukhov, A. B.; Gurchenko, A. D. Gusakov, E. Z.; D’yachenko, V. V.; Esipov, L. A.; Irzak, M. A. Kantor, M. Yu.; Kouprienko, D. V.; Saveliev, A. N.; Stepanov, A. Yu.; Shatalin, S. V.

    2015-12-15

    To analyze factors influencing the limiting value of the plasma density at which lower hybrid (LH) current drive terminates, the isotopic factor (the difference in the LH resonance densities in hydrogen and deuterium plasmas) was used for the first time in experiments carried out at the FT-2 tokamak. It is experimentally found that the efficiency of LH current drive in deuterium plasma is appreciably higher than that in hydrogen plasma. The significant role of the parametric decay of the LH pumping wave, which hampers the use of the LH range of RF waves for current drive at high plasma densities, is confirmed. It is demonstrated that the parameters characterizing LH current drive agree well with the earlier results obtained at large tokamaks.

  14. Tokamak Fusion Core Experiment: design studies based on superconducting and hybrid toroidal field coils. Design overview

    SciTech Connect

    Flanagan, C.A.

    1984-10-01

    This document is a design overview that describes the scoping studies and preconceptual design effort performed in FY 1983 on the Tokamak Fusion Core Experiment (TFCX) class of device. These studies focussed on devices with all-superconducting toroidal field (TF) coils and on devices with superconducting TF coils supplemented with copper TF coil inserts located in the bore of the TF coils in the shield region. Each class of device is designed to satisfy the mission of ignition and long pulse equilibrium burn. Typical design parameters are: major radius = 3.75 m, minor radius = 1.0 m, field on axis = 4.5 T, plasma current = 7.0 MA. These designs relay on lower hybrid (LHRH) current rampup and heating to ignition using ion cyclotron range of frequency (ICRF). A pumped limiter has been assumed for impurity control. The present document is a design overview; a more detailed design description is contained in a companion document.

  15. Targeted array CGH as a valuable molecular diagnostic approach: experience in the diagnosis of mitochondrial and metabolic disorders.

    PubMed

    Wang, Jing; Zhan, Hongli; Li, Fang-Yuan; Pursley, Amber N; Schmitt, Eric S; Wong, Lee-Jun

    2012-06-01

    Oligonucleotide array-based comparative genomic hybridization (aCGH) targeted to coding exons of genes of interest has been proven to be a valuable diagnostic tool to complement with Sanger sequencing for the detection of large deletions/duplications. We have developed a custom designed oligonucleotide aCGH platform for this purpose. This array platform provides tiled coverage of the entire mitochondrial genome and high-density coverage of a set of nuclear genes involving mitochondrial and metabolic disorders and can be used to evaluate large deletions in targeted genes. A total of 1280 DNA samples from patients suspected of having mitochondrial or metabolic disorders were evaluated using this targeted aCGH. We detected 40 (3%) pathogenic large deletions in unrelated individuals, including 6 in genes responsible for mitochondrial DNA (mtDNA) depletion syndromes, 23 in urea cycle genes, 11 in metabolic and related genes. Deletion breakpoints have been confirmed in 31 cases by PCR and sequencing. The possible deletion mechanism has been discussed. These results illustrate the successful utilization of targeted aCGH to detect large deletions in nuclear and mitochondrial genomes. This technology is particularly useful as a complementary diagnostic test in the context of a recessive disease when only one mutant allele is found by sequencing. For female carriers of X-linked disorders, if sequencing analysis does not detect point mutations, targeted aCGH should be considered for the detection of large heterozygous deletions. PMID:22494545

  16. Unlikely Combination of Experiments with a Novel High-Voltage CIGS Photovoltaic Array (Presentation)

    SciTech Connect

    del Cueto, J. A.; Sekulic, B. R.

    2006-05-01

    The goals of this study are to: (1) parameterize current-voltage (I-V) performance over a wide range of illumination and temperatures: (a) 50-1150 W/m{sup 2} irradiance, 5-65 C; (b) obtain array temperature coefficients; and (c) quantify energy production; (2) investigate high-voltage leakage currents from the CIS modules in a high-voltage array: determine dependence on moisture, temperature, and voltage bias and ascertain corrosion problems if any; and (3) study long-term power and energy production stability.

  17. Conceptual Design and Prototype Performance of Phased-array Antenna for EBWH/CD Experiments in QUEST

    NASA Astrophysics Data System (ADS)

    Idei, Hiroshi; Sakaguchi, Masatsugu; Nagata, Kazuya; Hanada, Kazuaki; Zushi, Hideki; Nakamura, Kazuo; Hasegawa, Makoto; Sato, Kohnosuke; Sakamoto, Mizuki; Kawasaki, Shoji; Nakashima, Hisatoshi; Higashijima, Aki

    Electron Bernstein Wave Heating and Current Drive (EBWH/CD) experiments have been conducted to sustain a spherical tokamak configuration in a steady state in QUEST. In the EBWH/CD experiments on QUEST, the O-X-B mode conversion scenario was selected for plasma current sustainment in rather low-density plasmas. A new phased-array antenna system was proposed to launch a pure elliptically-polarized O-mode in the oblique injection. The prototype antenna system was designed and its performance was checked at low power test facilities. Good focusing and steering properties were confirmed in the low power test.

  18. Hybrid NiS/CoO mesoporous nanosheet arrays on Ni foam for high-rate supercapacitors

    NASA Astrophysics Data System (ADS)

    Wu, Jianghong; Ouyang, Canbin; Dou, Shuo; Wang, Shuangyin

    2015-08-01

    A new hybrid of NiS/CoO porous nanosheets was synthesized on Ni foam by one-step electrodeposition method and used as an electrode for high-performance pseudocapacitance. The as-synthesized NiS/CoO porous nanosheets hybrid shows a high specific capacitance of 1054 F g-1 at a high current density of 6 A g-1, a good rate capability even at high current density (760 F g-1 at 20 A g-1) and a good long-term cycling stability (91.7% of the maximum specific capacitance after 3000 cycles). These excellent properties can be mainly attributed to the unique hierarchical porous structure with large surface area and interspaces which facilitate charge transfer and redox reaction. The enhancement in the interface contact between active material and substrate results in excellent conductivity of the electrode and a strong synergistic effect of NiS and CoO as individual constituents contributed to high capacitance of the hybrid electrode.

  19. A photoelectrochemical immunosensor for tris(2,3-dibromopropyl) isocyanurate detection with a multiple hybrid CdTe/Au-TiO2 nanotube arrays.

    PubMed

    Feng, Hui; Zhou, Liping; Li, Jiezhen; Tran T, ThanhThuy; Wang, Niya; Yuan, Lijuan; Yan, Zhihong; Cai, Qingyun

    2013-10-01

    In this paper, tris(2,3-dibromopropyl) isocyanurate (TBC) is for the first time as far as we know determined by ultrasensitive photoelectrochemical (PEC) immunoassay using an antibody-modified ternary hybrid CdTe/Au-TiO2 nanotube arrays (NTAs) photoelectrode, developed by the pulse electrodeposition technique. The as-prepared hybrid shows enhanced photon absorption and photocurrent response, which subsequently increased the photoelectrical conversion efficiency in the visible region. TBC-antibody (Ab) was developed in rabbits as a result of immunization with the BSA-TBC conjugate and covalently cross-linked onto the CdTe/Au-TiO2 NTAs. Since the photocurrent is highly dependent on the TiO2 surface properties, the specific interaction between TBC and the antibody results in a sensitive change in the photocurrent, which displayed a linear range of 5.0 × 10(-11) to 5.0 × 10(-5) M and a low detection limit of 5.0 × 10(-11) M for TBC determination. This proposed strategy highlights the application of TiO2 nanotube in visible-light-activated photoelectrochemical biosensing, which could largely reduce the destructive effect of UV light on biomolecules. PMID:23900298

  20. High current density and longtime stable field electron transfer from large-area densely arrayed graphene nanosheet-carbon nanotube hybrids.

    PubMed

    Deng, Jian-Hua; Cheng, Lin; Wang, Fan-Jie; Li, Guo-Zheng; Li, De-Jun; Cheng, Guo-An

    2014-12-10

    Achieving high current and longtime stable field emission from large area (larger than 1 mm(2)), densely arrayed emitters is of great importance in applications for vacuum electron sources. We report here the preparation of graphene nanosheet-carbon nanotube (GNS-CNT) hybrids by following a process of iron ion prebombardment on Si wafers, catalyst-free growth of GNSs on CNTs, and high-temperature annealing. Structural observations indicate that the iron ion prebombardment influences the growth of CNTs quite limitedly, and the self-assembled GNSs sparsely distributed on the tips of CNTs with their sharp edges unfolded outside. The field emission study indicates that the maximum emission current density (Jmax) is gradually promoted after these treatments, and the composition with GNSs is helpful for decreasing the operation fields of CNTs. An optimal Jmax up to 85.10 mA/cm(2) is achieved from a 4.65 mm(2) GNS-CNT sample, far larger than 7.41 mA/cm(2) for the as-grown CNTs. This great increase of Jmax is ascribed to the reinforced adhesion of GNS-CNT hybrids to substrates. We propose a rough calculation and find that this adhesion is promoted by 7.37 times after the three-step processing. We consider that both the ion prebombardment produced rough surface and the wrapping of CNT foot by catalyst residuals during thermal processing are responsible for this enhanced adhesion. Furthermore, the three-step prepared GNS-CNT hybrids present excellent field emission stability at high emission current densities (larger than 20 mA/cm(2)) after being perfectly aged. PMID:25335851

  1. Monolithic millimeter-wave diode array beam controllers: Theory and experiment

    NASA Technical Reports Server (NTRS)

    Sjogren, L. B.; Liu, H.-X. L.; Wang, F.; Liu, T.; Wu, W.; Qin, X.-H.; Chung, E.; Domier, C. W.; Luhmann, N. C., Jr.; Maserjian, J.

    1992-01-01

    In the current work, multi-function beam control arrays have been fabricated and have successfully demonstrated amplitude control of transmitted beams in the W and D bands (75-170 GHz). While these arrays are designed to provide beam control under DC bias operation, new designs for high-speed electronic and optical control are under development. These arrays will fill a need for high-speed watt-level beam switches in pulsed reflectometer systems under development for magnetic fusion plasma diagnostics. A second experimental accomplishment of the current work is the demonstration in the 100-170 GHz (D band) frequency range of a new technique for the measurement of the transmission phase as well as amplitude. Transmission data can serve as a means to extract ('de-embed') the grid parameters; phase information provides more complete data to assist in this process. Additional functions of the array beam controller yet to be tested include electronically controlled steering and focusing of a reflected beam. These have application in the areas of millimeter-wave electronic scanning radar and reflectometry, respectively.

  2. Planning for hybrid-cycle OTEC experiments using the HMTSTA test facility at the Natural Energy Laboratory of Hawaii

    SciTech Connect

    Panchal, C.; Rabas, T.; Genens, L.

    1989-01-01

    The US Department of Energy has built an experimental apparatus for studying the open-cycle Ocean Thermal Energy Conversion (OC-OTEC) system. Experiments using warm and cold seawater are currently uderway to validate the performance predictions for an OC-TEC flash evaporator, surface condenser, and direct-contact condenser. The hybrid cycle is another OTEC option that produces both power and desalinated water, it is comparable in capital cost to OC-OTEC, and it eliminates the problems associated with the large steam turbine. Means are presented in this paper for modifying the existing apparatus to conduct similar experiments on hybrid-cycle OTEC heat exchangers. These data are required to validate predictive methods of the components and for the system integration that were identified in an earlier study of hybrid-cycle OTEC power plants. 7 refs., 4 figs., 2 tabs.

  3. Planning for hybrid-cycle OTEC experiments using the HMTSTA test facility at the Natural Energy Laboratory of Hawaii

    NASA Astrophysics Data System (ADS)

    Panchal, C.; Rabas, T.; Genens, L.

    The U.S. Department of Energy has built an experimental apparatus for studying the open-cycle Ocean Thermal Energy Conversion (OC-OTEC) system. Experiments using warm and cold seawater are currently underway to validate the performance predictions for an OC-TEC flash evaporator, surface condenser, and direct-contact condenser. The hybrid cycle is another OTEC option that produces both power and desalinated water, it is comparable in capital cost to OC-OTEC, and it eliminates the problems associated with the large steam turbine. Means are presented or modifying the existing apparatus to conduct similar experiments on hybrid-cycle OTEC heat exchangers. These data are required to validate predictive methods of the components and for the system integration that were identified in an earlier study of hybrid-cycle OTEC power plants.

  4. Differential gene expression in the murine thymus assayed by quantitative hybridization of arrayed cDNA clones

    SciTech Connect

    Nguyen, C.; Rocha, D.; Granjeaud, S.

    1995-09-01

    High-throughput measurement of hybridization signatures obtained using complex probes prepared from poly(A){sup +} RNA and high-density cDNA colony filters is described. The performance of the system, elimination of artifacts, and verification of the validity of the data are discussed. cDNAs corresponding to sequences present at levels of approximately 0.01% in the complex probe can be detected. Good correlation is observed between expression profiles determined by this method and by Northern blotting. The method is applied to a preliminary investigation of differential expression in three cell types present in the murine thymus. 41 refs., 3 figs., 1 tab.

  5. Development of the Minimum Information Specification for in situ Hybridization and Immunohistochemistry Experiments (MISFISHIE)

    SciTech Connect

    Deutsch, Eric W.; Ball, Catherine A.; Bova, G. Steven; Brazma, Alvis; Bumgarner, Roger E.; Campbell, David; Causton, Helen C.; Christiansen, Jeff; Davidson, Duncan; Eichner, Lillian J.; Goo, Young Ah; Grimmond, Sean; Henrich, Thorsten; Johnson, Michael H.; Korb, Martin; Mills, Jason C.; Oudes, Asa; Parkinson, Helen E.; Pascal, Laura E.; Quackenbush, John; Ramialison, Mirana; Ringwald, Martin; Sansone, Susanna A.; Sherlock, Gavin; Stoeckert, Christian Jr. J.; Swedlow, Jason; Taylor, Ronald C.; Walashek, Laura; Zhou, Yi; Liu, Alvin Y.; True, Lawrence D.

    2006-06-06

    Background One purpose of the biomedical literature is to report results in sufficient detail so that the methods of data collection and analysis can be independently replicated and verified. In order to ensure that this level of detail is provided in published works, a minimum information specification is needed for each experimental data type and for this specification to be a requirement for publication in peer-reviewed journals. This is especially beneficial for researchers working with complex data types and experiments. A data content specification has already been widely accepted by, and directly benefited, the microarray community, and efforts are well underway to develop a comparable specification for proteomics data types. However, no similar specification exists for visual interpretation-based tissue protein and transcript abundance/localization experiments (hereafter referred to as ‘gene expression localization experiments’), such as in situ hybridization and experiments involving immunohistochemistry. Results Here we present for consideration a specification, called the “Minimum Information Specification For In Situ Hybridization and Immunohistochemistry Experiments (MISFISHIE)”. It is modelled after the MIAME (Minimum Information About a Microarray Experiment) specification for microarray experiments. Data specifications like MIAME and MISFISHIE specify the information content without specifying a format for encoding that information. The MISFISHIE specification describes six types of information that should be provided for each gene expression localization experiment: Experimental Design, Biomaterials and Treatments, Reporters, Staining, Imaging Data, and Image Characterizations. A general checklist is provided for quick and easy reference and to promote adherence to the specification. We consider that most articles describing gene expression localization studies do not fully provide the minimum information needed for independent verification

  6. DEVELOPMENT IN THE DIII-D TOKAMAK OF HYBRID OPERATION SCENARIOS FOR BURNING PLASMA EXPERIMENTS

    SciTech Connect

    LUCE,TC; WADE,MR; FERRON,JR; HYATT,AW; POLITZER,PA; SIPS,ACC

    2003-08-01

    OAK-B135 The basic parameters of proposed burning plasma experiments such as ITER and FIRE have been chosen based on analysis of multi-machine databases of confinement, stability, and divertor operation. given these specifications, it is of interest to run discharges in present-day machines such as DIII-D to verify the design basis and evaluate the margin available to achieve the mission goals. it is especially important to operate discharges which are stationary with respect to the current relaxation time scale ({tau}{sub R}) since it is well-known that higher performance can be achieved transiently. Attention has been focused on validating the baseline scenario for diverted machines--ELMing H-mode discharges with q{sub 95} = 3 with sawteeth. However, there is also interest in the ITER program to assess the feasibility of operating the tokamak in a mode to maximize the neutron fluence for the purpose of testing the design of various components critical to the nuclear fuel cycle and energy conversion systems in a fusion power plant. It was originally envisioned that these discharges would be intermediate between an inductive burn (baseline) scenario and a fully noninductive (steady state) scenario; therefore, this type of discharge has become known as a hybrid scenario. In the course of investigating these hybrid scenarios in DIII-D, two key results have been obtained. First, stationary discharges with q{sub 95} > 4 have been obtained which project to Q{sub fus} {approx} 10 in ITER. The projected duration of these discharges in ITER when using the full inductive flux capability is > 4000 s. (The significant engineering issues of site heat capacity, activation, and tritium consumption are beyond the scope of this work). Second, utilizing the same plasma initiation techniques as developed for the hybrid scenario, discharges at q{sub 95} = 3.2 project to near ignition in ITER, even with reduced parameters. This indicates the ITER design has significant performance

  7. Investigating the Inverse Square Law with the Timepix Hybrid Silicon Pixel Detector: A CERN [at] School Demonstration Experiment

    ERIC Educational Resources Information Center

    Whyntie, T.; Parker, B.

    2013-01-01

    The Timepix hybrid silicon pixel detector has been used to investigate the inverse square law of radiation from a point source as a demonstration of the CERN [at] school detector kit capabilities. The experiment described uses a Timepix detector to detect the gamma rays emitted by an [superscript 241]Am radioactive source at a number of different…

  8. Creation of a market for small rocket experiments through CAMUI hybrid rocket

    NASA Astrophysics Data System (ADS)

    Nagata, Harunori; Watanabe, Mikio; Ito, Mitsunori; Maeda, Takenori; Uematsu, Tsutomu; Totani, Tsuyoshi; Kudo, Isao

    2005-08-01

    By introducing various innovative ideas, the difficult-to-develop small hybrid-type rocket is successfully developed. The main purpose is to drastically reduce the cost of rocket experiments and thus attract potential users such as metrological and microgravity researchers. A key idea is a new fuel grain design to accelerate the gasification rate of solid fuel. The new fuel grain design, designated as CAMUI as an abbreviation of "Cascaded Multistage Impinging-jet", is that the gas flow repeatedly collides with the solid fuel surface to accelerate the heat transfer to the fuel. To install a regenerative cooling system using cryogenic liquid oxygen as coolant in a small launcher, the authors devised a valveless supply system (with no valves in the liquid oxygen flow line). Four serial successful launch verification tests by 10 kg vehicle equipped with a 50 kgf thrust CAMUI motor have shown the feasibility of the motor system. The meteorological observation model of 400 kgf class motor is under development and the development of microgravity experiment class of 1.5 to 2 tonf motor will follow subsequently. The authors plan to complete the developoment of the 400 kgf class motor for meterological observation model by the end of FY2005.

  9. Lower Hybrid Current Drive and ion Bernstein wave heating experiments on PBX-M

    SciTech Connect

    Bernabei, S.

    1994-02-01

    This paper presents an overview of the experiments conducted on PBX-M to control on evaluate the feasibility and effect of current profile and pressure profile control on the plasma stability. Utilizing the inaccessibility of the Lower Hybrid waves, it has been possible to obtain a certain degree of power deposition localization and off-axis current drive. The effect of fast electron diffusion has been studied and found not to be a limiting factor; consequently, the current profile has been modified in a non-transient manner. More serious is the destabilization of global MHD modes, due to the change of the current profile, which can lead to disruption or to a rapid radial redistribution of the fast electron population. Experiments with Ion Bernstein wave heating have shown that power can be deposited off-aids and that the ion temperature can be modified locally. Application of IBW into a strongly Neutral Beam (NBI) heated H-mode plasma causes a substantial increase of thermal and particle confinement in the core of the plasma: this produces a localized bootstrap current sufficient to significantly raise the value of q(O). We propose to refer to this condition as the CH-mode.

  10. Development of CAMUI hybrid rocket to create a market for small rocket experiments

    NASA Astrophysics Data System (ADS)

    Nagata, Harunori; Ito, Mitsunori; Maeda, Takenori; Watanabe, Mikio; Uematsu, Tsutomu; Totani, Tsuyoshi; Kudo, Isao

    2006-07-01

    By introducing various innovative ideas, the difficult-to-develop small hybrid-type rocket is successfully developed. The main purpose is to drastically reduce the cost of rocket experiments and thus, attract potential users such as metrological and microgravity researchers. A key idea is a new fuel grain design to accelerate the gasification rate of solid fuel. The new fuel grain design, designated as CAMUI as an abbreviation of "cascaded multistage impinging-jet", is that the gas flow repeatedly collides with the solid fuel surface to accelerate the heat transfer to the fuel. To install a regenerative cooling system using cryogenic liquid oxygen as coolant in a small launcher, the authors devised a valveless supply system (with no valves in the liquid oxygen flow line). Four serial successful launch verification tests by 10 kg vehicle equipped with a 50 kgf thrust CAMUI motor have shown the feasibility of the motor system. The meteorological observation model of 400 kgf class motor is under development and the development of microgravity experiment class of 1.5-2 tonf motor will follow subsequently. The authors plan to complete the development of the 400 kgf class motor for meteorological observation model by the end of FY2005.

  11. A nested array of rRNA targeted probes for the detection and identification of enterococci by reverse hybridization.

    PubMed

    Behr, T; Koob, C; Schedl, M; Mehlen, A; Meier, H; Knopp, D; Frahm, E; Obst, U; Schleifer, K; Niessner, R; Ludwig, W

    2000-12-01

    Complete 23S and almost complete 16S rRNA gene sequences were determined for the type strains of the validly described Enterococcus species, Melissococcus pluton and Tetragenococcus halophilus. A comprehensive set of rRNA targeted specific oligonucleotide hybridization probes was designed according to the multiple probe concept. In silico probe design and evaluation was performed using the respective tools of the ARB program package in combination with the ARB databases comprising the currently available 16S as well as 23S rRNA primary structures. The probes were optimized with respect to their application for reverse hybridization in microplate format. The target comprising 16S and 23S rDNA was amplified and labeled by PCR (polymerase chain reaction) using general primers targeting a wide spectrum of bacteria. Alternatively, amplification of two adjacent rDNA fragments of enterococci was performed by using specific primers. In vitro evaluation of the probe set was done including all Enterococcus type strains, and a selection of other representatives of the gram-positive bacteria with a low genomic DNA G+C content. The optimized probe set was used to analyze enriched drinking water samples as well as original samples from waste water treatment plants. PMID:11249027

  12. Integrative self-assembly of functional hybrid nanoconstructs by inorganic wrapping of single biomolecules, biomolecule arrays and organic supramolecular assemblies

    NASA Astrophysics Data System (ADS)

    Patil, Avinash J.; Li, Mei; Mann, Stephen

    2013-07-01

    Synthesis of functional hybrid nanoscale objects has been a core focus of the rapidly progressing field of nanomaterials science. In particular, there has been significant interest in the integration of evolutionally optimized biological systems such as proteins, DNA, virus particles and cells with functional inorganic building blocks to construct mesoscopic architectures and nanostructured materials. However, in many cases the fragile nature of the biomolecules seriously constrains their potential applications. As a consequence, there is an on-going quest for the development of novel strategies to modulate the thermal and chemical stabilities, and performance of biomolecules under adverse conditions. This feature article highlights new methods of ``inorganic molecular wrapping'' of single or multiple protein molecules, individual double-stranded DNA helices, lipid bilayer vesicles and self-assembled organic dye superstructures using inorganic building blocks to produce bio-inorganic nanoconstructs with core-shell type structures. We show that spatial isolation of the functional biological nanostructures as ``armour-plated'' enzyme molecules or polynucleotide strands not only maintains their intact structure and biochemical properties, but also enables the fabrication of novel hybrid nanomaterials for potential applications in diverse areas of bionanotechnology.

  13. MIR Solar Array Return Experiment: Power Performance Measurements and Molecular Contamination Analysis Results

    NASA Technical Reports Server (NTRS)

    Visentine, James; Kinard, William; Brinker, David; Scheiman, David; Banks, Bruce; Albyn, Keith; Hornung, Steve; See, Thomas

    2001-01-01

    A solar array segment was recently removed from the Mir core module and returned for ground-based analysis. The segment, which is similar to the ones the Russians have provided for the FGB and Service Modules, was microscopically examined and disassembled by US and Russian science teams. Laboratory analyses have shown the segment to he heavily contaminated by an organic silicone coating, which was converted to an organic silicate film by reactions with atomic oxygen within the. orbital flight environment. The source of the contaminant was a silicone polymer used by the Russians as an adhesive and bonding agent during segment construction. During its life cycle, the array experienced a reduction in power performance from approx. 12%, when it was new and first deployed, to approx. 5%, when it was taken out of service. However, current-voltage measurements of three contaminated cells and three pristine, Russian standard cells have shown that very little degradation in solar array performance was due to the silicate contaminants on the solar cell surfaces. The primary sources of performance degradation is attributed to "thermal hot-spotting" or electrical arcing; orbital debris and micrometeoroid impacts; and possibly to the degradation of the solar cells and interconnects caused by radiation damage from high energy protons and electrons.

  14. Hybrid Taxis Give Fuel Economy a Lift, Clean Cities, Fleet Experiences, April 2009 (Fact Sheet)

    SciTech Connect

    Not Available

    2009-04-01

    Clean Cities helped Boston, San Antonio, and Cambridge create hybrid taxi programs. The hybrid taxis are able to achieve about twice the gas mileage of a conventional taxi while helping cut gasoline use and fuel costs. Tax credits and other incentives are helping both company owners and drivers make the switch to hybrids. Program leaders have learned some important lessons other cities can benefit from including learning a city's taxi structure, relaying benefits to drivers, and understanding the needs of owners.

  15. Nucleation and Growth of Ordered Arrays of Silver Nanoparticles on Peptide Nanofibers: Hybrid Nanostructures with Antimicrobial Properties.

    PubMed

    Pazos, Elena; Sleep, Eduard; Rubert Pérez, Charles M; Lee, Sungsoo S; Tantakitti, Faifan; Stupp, Samuel I

    2016-05-01

    Silver nanoparticles have been of great interest as plasmonic substrates for sensing and imaging, catalysts, or antimicrobial systems. Their physical properties are strongly dependent on parameters that remain challenging to control such as size, chemical composition, and spatial distribution. We report here on supramolecular assemblies of a novel peptide amphiphile containing aldehyde functionality in order to reduce silver ions and subsequently nucleate silver metal nanoparticles in water. This system spontaneously generates monodisperse silver particles at fairly regular distances along the length of the filamentous organic assemblies. The metal-organic hybrid structures exhibited antimicrobial activity and significantly less toxicity toward eukaryotic cells. Metallized organic nanofibers of the type described here offer the possibility to create hydrogels, which integrate the useful functions of silver nanoparticles with controllable metallic content. PMID:27103596

  16. GENOME-WIDE MAPPING OF COPY NUMBER VARIATIONS IN COMMERCIAL HYBRID PIGS USING A HIGH-DENSITY SNP GENOTYPING ARRAY.

    PubMed

    Zhou, L S; Li, J; Yang, J; Liu, C L; Xie, X H; He, Y N; Liu, X X; Xin, W S; Zhang, W C; Ren, J; Ma, J W; Huang, L S

    2016-01-01

    Copy number variations (CNVs) are important forms of structural variation in human and animals and can be considered as a major genetic component of phenotypic diversity. Here we used the Illumina PorcineSNP60 BeadChip V2 and a DLY [Duroc x (Large White x Landrace)] commercial hybrid population to identify 272 CNVs belonging to 165 CNV regions (CNVRs), of which 66 are new. As CNVRs are specific to origin of population, our DLY-specific data is an important complementary to the existing CNV map in the pig genome. Eight CNVRs were selected. for validation by quantitative real-time PCR (qRT-PCR) and the accurate rate was high (87.25%). Gene function analysis suggested that a common CNVR may play an important role in multiple traits, including growth rate and carcass quality. PMID:27183798

  17. Calibration of photomultiplier tubes for the fluorescence detector of telescope array experiment using a Rayleigh scattered laser beam

    NASA Astrophysics Data System (ADS)

    Kawana, Shingo; Sakurai, Nobuyuki; Fujii, Toshihiro; Fukushima, Masaki; Inoue, Naoya; Matthews, John N.; Ogio, Shoichi; Sagawa, Hiroyuki; Taketa, Akimichi; Takita, Masato; Thomas, Stan B.; Tokuno, Hisao; Tsunesada, Yoshiki; Udo, Shigeharu; Wiencke, Lawrence R.

    2012-07-01

    We performed photometric calibration of the PhotoMultiplier Tube (PMT) and readout electronics used for the new fluorescence detectors of the Telescope Array (TA) experiment using Rayleigh scattered photons from a pulsed nitrogen laser beam. The experimental setup, measurement procedure, and results of calibration are described. The total systematic uncertainty of the calibration is estimated to be 7.2%. An additional uncertainty of 3.7% is introduced by the transport of the calibrated PMTs from the laboratory to the TA experimental site.

  18. Compact field programmable gate array-based pulse-sequencer and radio-frequency generator for experiments with trapped atoms.

    PubMed

    Pruttivarasin, Thaned; Katori, Hidetoshi

    2015-11-01

    We present a compact field-programmable gate array (FPGA) based pulse sequencer and radio-frequency (RF) generator suitable for experiments with cold trapped ions and atoms. The unit is capable of outputting a pulse sequence with at least 32 transistor-transistor logic (TTL) channels with a timing resolution of 40 ns and contains a built-in 100 MHz frequency counter for counting electrical pulses from a photo-multiplier tube. There are 16 independent direct-digital-synthesizers RF sources with fast (rise-time of ∼60 ns) amplitude switching and sub-mHz frequency tuning from 0 to 800 MHz. PMID:26628171

  19. Compact field programmable gate array-based pulse-sequencer and radio-frequency generator for experiments with trapped atoms

    SciTech Connect

    Pruttivarasin, Thaned; Katori, Hidetoshi

    2015-11-15

    We present a compact field-programmable gate array (FPGA) based pulse sequencer and radio-frequency (RF) generator suitable for experiments with cold trapped ions and atoms. The unit is capable of outputting a pulse sequence with at least 32 transistor-transistor logic (TTL) channels with a timing resolution of 40 ns and contains a built-in 100 MHz frequency counter for counting electrical pulses from a photo-multiplier tube. There are 16 independent direct-digital-synthesizers RF sources with fast (rise-time of ∼60 ns) amplitude switching and sub-mHz frequency tuning from 0 to 800 MHz.

  20. Sample-inverted reflow technique for fabrication of a revolved-hyperboloid microlens array in hybrid solgel glass.

    PubMed

    He, Miao; Yuan, Xiaocong; Bu, Jing

    2004-09-01

    We propose a novel fabrication method, which is referred to as the sample-inverted reflow technique, to fabricate a refractive microlens array (MLA) with a revolved-hyperboloid profile in a solgel material. The fabricated solgel MLA demonstrates an excellent smooth profile with a fabrication error much less than the difference between the revolved hyperboloid and the spherical surface. In an application of coupling a laser diode (LD) to a single-mode fiber (SMF), we propose a two-MLA coupling scheme in which two revolved-hyperboloid MLAs are used between the LD and the SMF. In this configuration the coupling efficiency achieves 81.7% (-0.88 dB). PMID:15455761

  1. Analysis of a Splice Array Experiment Elucidates Roles of Chromatin Elongation Factor Spt4–5 in Splicing

    PubMed Central

    2005-01-01

    Splicing is an important process for regulation of gene expression in eukaryotes, and it has important functional links to other steps of gene expression. Two examples of these linkages include Ceg1, a component of the mRNA capping enzyme, and the chromatin elongation factors Spt4–5, both of which have recently been shown to play a role in the normal splicing of several genes in the yeast Saccharomyces cerevisiae. Using a genomic approach to characterize the roles of Spt4–5 in splicing, we used splicing-sensitive DNA microarrays to identify specific sets of genes that are mis-spliced in ceg1, spt4, and spt5 mutants. In the context of a complex, nested, experimental design featuring 22 dye-swap array hybridizations, comprising both biological and technical replicates, we applied five appropriate statistical models for assessing differential expression between wild-type and the mutants. To refine selection of differential expression genes, we then used a robust model-synthesizing approach, Differential Expression via Distance Synthesis, to integrate all five models. The resultant list of differentially expressed genes was then further analyzed with regard to select attributes: we found that highly transcribed genes with long introns were most sensitive to spt mutations. QPCR confirmation of differential expression was established for the limited number of genes evaluated. In this paper, we showcase splicing array technology, as well as powerful, yet general, statistical methodology for assessing differential expression, in the context of a real, complex experimental design. Our results suggest that the Spt4–Spt5 complex may help coordinate splicing with transcription under conditions that present kinetic challenges to spliceosome assembly or function. PMID:16172632

  2. Design of a 5-MA 100-ns linear-transformer-driver accelerator for wire array Z-pinch experiments

    NASA Astrophysics Data System (ADS)

    Zhou, Lin; Li, Zhenghong; Wang, Zhen; Liang, Chuan; Li, Mingjia; Qi, Jianmin; Chu, Yanyun

    2016-03-01

    The linear-transformer-driver (LTD) is a recently developed pulsed-power technology that shows great promise for a number of applications. These include a Z -pinch-driven fission-fusion-hybrid reactor that is being developed by the Chinese Academy of Engineering Physics. In support of the reactor development effort, we are planning to build an LTD-based accelerator that is optimized for driving wire-array Z -pinch loads. The accelerator comprises six modules in parallel, each of which has eight series 0.8-MA LTD cavities in a voltage-adder configuration. Vacuum transmission lines are used from the interior of the adder to the central vacuum chamber where the load is placed. Thus the traditional stack-flashover problem is eliminated. The machine is 3.2 m tall and 12 m in outer diameter including supports. A prototype cavity was built and tested for more than 6000 shots intermittently at a repetition rate of 0.1 Hz. A novel trigger, in which only one input trigger pulse is needed by utilizing an internal trigger brick, was developed and successfully verified in these shots. A full circuit modeling was conducted for the accelerator. The simulation result shows that a current pulse rising to 5.2 MA in 91 ns (10%-90%) can be delivered to the wire-array load, which is 1.5 cm in height, 1.2 cm in initial radius, and 1 mg in mass. The maximum implosion velocity of the load is 32 cm /μ s when compressed to 0.1 of the initial radius. The maximum kinetic energy is 78 kJ, which is 11.7% of the electric energy stored in the capacitors. This accelerator is supposed to enable a radiation energy efficiency of 20%-30%, providing a high efficient facility for research on the fast Z pinch and technologies for repetition-rate-operated accelerators.

  3. Experiment on fluidelastic instability of loosely supported tube arrays in crossflow

    SciTech Connect

    Chen, S.S.; Zhu, S.; Cai, Y.

    1993-06-01

    A tube array supported by baffle plates in crossflow may be subjected to fluidelastic instability in the tube-support-plate-inactive mode. An experimental study is presented to characterize the tube motion. Three series of tests were performed to measure tube displacements as a function of flow velocity for different clearances. The motion was examined by root-mean-square values of tube displacements, power spectral densities, phase planes, Poincare maps, and Lyapunov exponents. The experimental data agree reasonably well with the analytical model, based on the unsteady flow theory.

  4. The physics of sub-critical lattices in accelerator driven hybrid systems: The MUSE experiments in the MASURCA facility

    SciTech Connect

    Chauvin, J. P.; Lebrat, J. F.; Soule, R.; Martini, M.; Jacqmin, R.; Imel, G. R.; Salvatores, M.

    1999-06-10

    Since 1991, the CEA has studied the physics of hybrid systems, involving a sub-critical reactor coupled with an accelerator. These studies have provided information on the potential of hybrid systems to transmute actinides and, long lived fission products. The potential of such a system remains to be proven, specifically in terms of the physical understanding of the different phenomena involved and their modelling, as well as in terms of experimental validation of coupled systems, sub-critical environment/accelerator. This validation must be achieved through mock-up studies of the sub-critical environments coupled to a source of external neutrons. The MUSE-4 mock-up experiment is planed at the MASURCA facility and will use an accelerator coupled to a tritium target. The great step between the generator used in the past and the accelerator will allow to increase the knowledge in hybrid physic and to decrease the experimental biases and the measurement uncertainties.

  5. Analysis of genomic alterations in neuroblastoma by multiplex ligation-dependent probe amplification and array comparative genomic hybridization: a comparison of results.

    PubMed

    Combaret, Valérie; Iacono, Isabelle; Bréjon, Stéphanie; Schleiermacher, Gudrun; Pierron, Gäelle; Couturier, Jérôme; Bergeron, Christophe; Blay, Jean-Yves

    2012-12-01

    In cases of neuroblastoma, recurring genetic alterations--losses of the 1p, 3p, 4p, and 11q and/or gains of 1q, 2p, and 17q chromosome arms--are currently used to define the therapeutic strategy in therapeutic protocols for low- and intermediate-risk patients. Different genome-wide analysis techniques, such as array comparative genomic hybridization (aCGH) or multiplex ligation-dependent probe amplification (MLPA), have been suggested for detecting chromosome segmental abnormalities. In this study, we compared the results of the two technologies in the analyses of the DNA of tumor samples from 91 neuroblastoma patients. Similar results were obtained with the two techniques for 75 samples (82%). In five cases (5.5%), the MLPA results were not interpretable. Discrepancies between the aCGH and MLPA results were observed in 11 cases (12%). Among the discrepancies, a 18q21.2-qter gain and 16p11.2 and 11q14.1-q14.3 losses were detected only by aCGH. The MLPA results showed that the 7p, 7q, and 14q chromosome arms were affected in six cases, while in two cases, 2p and 17q gains were observed; these results were confirmed by neither aCGH nor fluorescence in situ hybridization (FISH) analysis. Because of the higher sensitivity and specificity of genome-wide information, reasonable cost, and shorter time of aCGH analysis, we recommend the aCGH procedure for the analysis of genomic alterations in neuroblastoma. PMID:23265803

  6. Hybrid simulation of toroidal Alfvén eigenmode on the National Spherical Torus Experiment

    SciTech Connect

    Liu, D.; Fu, G. Y.; Podestà, M.; Breslau, J. A.; Fredrickson, E. D.; Crocker, N. A.; Kubota, S.

    2015-04-15

    Energetic particle modes and Alfvén eigenmodes driven by super-Alfvénic fast ions are routinely observed in neutral beam heated plasmas on the National Spherical Torus eXperiment (NSTX). These modes can significantly impact fast ion transport and thus cause fast ion redistribution or loss. Self-consistent linear simulations of Toroidal Alfvén Eigenmodes (TAEs) in NSTX plasmas have been carried out with the kinetic/magnetohydrodynamic hybrid code M3D-K using experimental plasma parameters and profiles including plasma toroidal rotation. The simulations show that unstable TAEs with n=3,4, or 5 can be excited by the fast ions from neutral beam injection. The simulated mode frequency, mode radial structure, and phase shift are consistent with measurements from a multi-channel microwave reflectometer diagnostic. A sensitivity study on plasma toroidal rotation, safety factor q profile, and initial fast ion distribution is performed. The simulations show that rotation can have a significant destabilizing effect when the rotation is comparable or larger than the experimental level. The mode growth rate is sensitive to q profile and fast ion distribution. Although mode structure and peak position depend somewhat on q profile and plasma rotation, the variation of synthetic reflectometer response is within experimental uncertainty and it is not sensitive enough to see the difference clearly.

  7. Data Analysis for the NASA/Boeing Hybrid Laminar Flow Control Crossflow Experiment

    NASA Technical Reports Server (NTRS)

    Eppink, Jenna L.; Wlezien, Richard

    2011-01-01

    The Hybrid-Laminar Flow Control (HLFC) Crossflow Experiment, completed in 1995. generated a large database of boundary layer stability and transition data that was only partially analyzed before data analysis was abruptly ended in the late 1990's. Renewed interest in laminar flow technologies prompted additional data analysis, to integrate all data, including some post-test roughness and porosity measurements. The objective is to gain new insights into the effects of suction on boundary layer stability. A number of challenges were encountered during the data analysis, and their solutions are discussed in detail. They include the effect of the probe vibration, the effect of the time-varying surface temperature on traveling crossflow instabilities, and the effect of the stationary crossflow modes on the approximation of wall location. Despite the low turbulence intensity of the wind tunnel (0.01 to 0.02%), traveling crosflow disturbances were present in the data, in some cases at amplitudes up to 1% of the freestream velocity. However, the data suggests that transition was dominated by stationary crossflow. Traveling crossflow results and stationary data in the presence of suction are compared with linear parabolized stability equations results as a way of testing the quality of the results.

  8. Design and implementation of a multichannel millimeter wave interferometer for the Compact Toroidal Hybrid experiment

    SciTech Connect

    Miller, M. C.; Hanson, J. D.; Hartwell, G. J.; Knowlton, S. F.; Maurer, D. A.; Stevenson, B. A.

    2012-10-15

    A three-channel 1 mm wave interferometer has been designed, assembled, and installed on the Compact Toroidal Hybrid torsatron (CTH). The interferometer design makes novel use of a subharmonic mixer for detection, which simplifies alignment. It employs a single electronically tunable source that is repetitively chirped using a sawtooth waveform of frequency up to 1 MHz. The 15.25 GHz drive oscillator is multiplied in two stages to 122 GHz before a final doubler stage brings it to 244 GHz. Local oscillator (LO) power at 122 GHz is directed through waveguide to the LO input of the subharmonic mixer of each viewing chord, simplifying alignment. Phase detection is performed by directly digitizing the amplified mixer outputs at 50 MHz and processing them with a software algorithm. Initial measurements made with the central chord of the new interferometer agree with those from the existing 4 mm system at low densities. The 1 mm system performs well in current-driven discharges reaching densities over 10{sup 19} m{sup -3}, whereas the lower frequency interferometer is found to be less reliable due to loss of fringes. This is a critical improvement for experiments studying the onset, avoidance, and vacuum magnetic transform dependence of disruptions in the CTH device.

  9. Design and implementation of a multichannel millimeter wave interferometer for the Compact Toroidal Hybrid experiment.

    PubMed

    Miller, M C; Hanson, J D; Hartwell, G J; Knowlton, S F; Maurer, D A; Stevenson, B A

    2012-10-01

    A three-channel 1 mm wave interferometer has been designed, assembled, and installed on the Compact Toroidal Hybrid torsatron (CTH). The interferometer design makes novel use of a subharmonic mixer for detection, which simplifies alignment. It employs a single electronically tunable source that is repetitively chirped using a sawtooth waveform of frequency up to 1 MHz. The 15.25 GHz drive oscillator is multiplied in two stages to 122 GHz before a final doubler stage brings it to 244 GHz. Local oscillator (LO) power at 122 GHz is directed through waveguide to the LO input of the subharmonic mixer of each viewing chord, simplifying alignment. Phase detection is performed by directly digitizing the amplified mixer outputs at 50 MHz and processing them with a software algorithm. Initial measurements made with the central chord of the new interferometer agree with those from the existing 4 mm system at low densities. The 1 mm system performs well in current-driven discharges reaching densities over 10(19) m(-3), whereas the lower frequency interferometer is found to be less reliable due to loss of fringes. This is a critical improvement for experiments studying the onset, avoidance, and vacuum magnetic transform dependence of disruptions in the CTH device. PMID:23126990

  10. Intracranial Dual-Mode IVUS and Hyperthermia Using Circular Arrays: Preliminary Experiments

    PubMed Central

    Patel, Vivek; Light, Edward; Herickhoff, Carl; Grant, Gerald; Britz, Gavin; Wilson, Christy; Palmeri, Mark; Smith, Stephen

    2013-01-01

    In this study, we investigated the feasibility of using 3.5-Fr (3 Fr = 1 mm) circular phased-array intravascular ultrasound (IVUS) catheters for minimally invasive, image-guided hyperthermia treatment of tumors in the brain. Feasibility was demonstrated in two ways: (1) by inserting a 3.5-Fr IVUS catheter through skull burr holes, for 20 MHz brain imaging in the pig model, and (2) by testing a modified circular array for therapy potential with 18.5-MHz and 9-MHz continuous wave (CW) excitation. The imaging transducer’s performance was superior to our previous 9-MHz mechanical IVUS prototype. The therapy catheter transducer was driven by CW electrical power at 18.5 MHz, achieving temperature changes reaching +8°C at a depth of 2 mm in a human glioblastoma grown on the flank of a mouse with minimal transducer resistive heating of +2°C. Further hyperthermia trials showed that 9-MHz CW excitation produced temperature changes of +4.5°C at a depth of 12 mm—a sufficient temperature rise for our long-term goal of targeted, controlled drug release via thermosensitive liposomes for therapeutic treatment of 1-cm-diameter glioblastomas. PMID:23287504

  11. Hybrid Taxis Give Fuel Economy a Lift -Clean Cities Fleet Experiences -

    SciTech Connect

    2009-04-01

    The hybrid taxis are able to achieve about twice the gas mileage of a conventional taxi while helping cut gasoline use and fuel costs. Tax credits and other incentives are helping both company owners and drivers make the switch to hybrids.

  12. Pre-Service Teachers' Experiences Implementing a Hybrid Curriculum: Sport Education and Teaching Games for Understanding

    ERIC Educational Resources Information Center

    Stran, Margaret; Sinelnikov, Oleg; Woodruff, Elizabeth

    2012-01-01

    A hybrid Sport Education (SE) and Teaching Games for Understanding (TGfU) pedagogical model shifts responsibilities to students and enhances game play by focusing on tactical problems. The purpose of this study was to (1) examine pre-service teachers' (PTs) perceptions teaching a SE-TGfU hybrid; and (2) identify facilitators and inhibitors that…

  13. Magma Genesis in the Hawaiian Hot Spot: From melting experiments on basalt/peridotite hybrid source

    NASA Astrophysics Data System (ADS)

    Takahashi, E.

    2003-12-01

    + gar and has 13-15 wt% MgO. Compared with partial melt of KLB-1 at 1500-1525C (Hirose and Kushiro, 1993), the basalt/peridotite hybrid melts are much lower in Al2O3 and CaO but are distinctly higher in K2O and TiO2. Compared with partial melt of KLB-1+50%MORB at 1500-1525C (Kogiso et al., 1998), melt in this study are much higher in SiO2 but lower in Al2O3. Among the three sets of experiments at 2.8-3.0GPa, compositions of the basalt/peridotite hybrid melts are most similar to the primitive Hawaiian tholeiite. Various hypotheses have been proposed to explain the chemical character of the Hawaiian magma (e.g., involvement of a metasomatic component at the base of the Pacific plate, melting of a fertile lower mantle component, melting at much higher pressure, etc). Based on the above experiments, I propose that Hawaiian tholeiite magmas are produced in basalt-peridotite reaction domains in the plume. The systematic change in the SiO2 content of Hawaiian tholeiites (from lower to higher, Loihi, Kilauea and Mauna Loa) could be explained by lowering melting temperatures in magma feeding zones from Loihi to Mauna Loa. This model predicts that the PMT for the Hawaiian plume could be roughly 100C lower than the previous model (PMT=1558C, Watson & McKenzie, 1991) and the involvement of eclogite component in magma genesis in the Hawaiian tholeiite would be 30 to 100%, which is much higher than the previous estimate (0-10%, Hauri, 1996).

  14. Towards a holistic assessment of the user experience with hybrid BCIs

    NASA Astrophysics Data System (ADS)

    Lorenz, Romy; Pascual, Javier; Blankertz, Benjamin; Vidaurre, Carmen

    2014-06-01

    Objective. In recent years, brain-computer interfaces (BCIs) have become mature enough to immensely benefit from the expertise and tools established in the field of human-computer interaction (HCI). One of the core objectives in HCI research is the design of systems that provide a pleasurable user experience (UX). While the majority of BCI studies exclusively evaluate common efficiency measures such as classification accuracy and speed, single research groups have begun to look at further usability aspects such as ease of use, workload and learnability. However, these evaluation metrics only cover pragmatic aspects of UX while still not considering the hedonic quality of UX. In order to gain a holistic perspective on UX, hedonic quality aspects such as motivation and frustration were also taken into account for our evaluation of three BCI-driven interfaces, which were proposed to be used as a two-stage neuroprosthetic control within the EU project MUNDUS. Approach. At the first stage, one of six possible actions was selected and either confirmed or cancelled at the second stage. For the experiment, a solely event-related-potential-based interface (ERP-ERP) and two hybrid solutions were tested that were controlled by ERP and motor imagery (MI)—resulting in the two possible combinations: ERP selection/MI confirmation (ERP-MI) or MI selection/ERP confirmation (MI-ERP). Behavioural, subjective and encephalographic (EEG) data of 12 healthy subjects were collected during an online experiment with the three graphical user interfaces (GUIs). Main results. Results showed a significantly greater pragmatic quality (in terms of accuracy, efficiency, workload, use quality and learnability) for the ERP-ERP and ERP-MI GUIs in contrast to the MI-ERP GUI. Consequently, the MI-ERP GUI is least suited for use as a neuroprosthetic control. With respect to the comparison of the ERP-ERP and ERP-MI GUIs, no significant differences in pragmatic and hedonic quality of UX were found

  15. Broadband sidebands generated by parametric instability in lower hybrid current drive experiments on EAST

    SciTech Connect

    Amicucci, L. Castaldo, C.; Cesario, R.; Giovannozzi, E.; Tuccillo, A. A.; Ding, B. J.; Li, M. H.

    2015-12-10

    Modern research on nuclear fusion energy, based on the tokamak concept, has strong need of tools for actively driving non-inductive current especially at the periphery of plasma column, where tools available so far have poor efficiency. This is essential for solving one of the most critical problems for thermonuclear reactor, consisting in how to achieve the figure of fusion gain in the context of sufficient stability. The lower hybrid current drive (LHCD) effect has the potential capability of driving current at large radii of reactor plasma with high efficiency [1]. Experiments recently carried out on EAST showed that a strong activity of LH sideband waves (from the RF probe spectra), accompanied by weak core penetration of the coupled LH power, is present when operating at relatively high plasma densities. Previous theoretical results, confirmed by experiments on FTU, showed that the LH sideband phenomenon is produced by parametric instability (PI), which are mitigated by higher plasma edge temperatures. This condition is thus useful for enabling the LH power propagation when operating with profiles having high plasma densities even at the edge. In the present work, we show new PI modeling of EAST plasmas data, obtained in condition of higher plasma edge temperature due to chamber lithisation. The obtained trend of the PI frequencies and growth rates is consistent with data of RF probe spectra, available in different regimes of lithisated and not lithisated vessel. Moreover, these spectra are interpreted as PI effect occurring at the periphery of plasma column, however in the low field side where the LH power is coupled.

  16. Broadband sidebands generated by parametric instability in lower hybrid current drive experiments on EAST

    NASA Astrophysics Data System (ADS)

    Amicucci, L.; Ding, B. J.; Castaldo, C.; Cesario, R.; Giovannozzi, E.; Li, M. H.; Tuccillo, A. A.

    2015-12-01

    Modern research on nuclear fusion energy, based on the tokamak concept, has strong need of tools for actively driving non-inductive current especially at the periphery of plasma column, where tools available so far have poor efficiency. This is essential for solving one of the most critical problems for thermonuclear reactor, consisting in how to achieve the figure of fusion gain in the context of sufficient stability. The lower hybrid current drive (LHCD) effect has the potential capability of driving current at large radii of reactor plasma with high efficiency [1]. Experiments recently carried out on EAST showed that a strong activity of LH sideband waves (from the RF probe spectra), accompanied by weak core penetration of the coupled LH power, is present when operating at relatively high plasma densities. Previous theoretical results, confirmed by experiments on FTU, showed that the LH sideband phenomenon is produced by parametric instability (PI), which are mitigated by higher plasma edge temperatures. This condition is thus useful for enabling the LH power propagation when operating with profiles having high plasma densities even at the edge. In the present work, we show new PI modeling of EAST plasmas data, obtained in condition of higher plasma edge temperature due to chamber lithisation. The obtained trend of the PI frequencies and growth rates is consistent with data of RF probe spectra, available in different regimes of lithisated and not lithisated vessel. Moreover, these spectra are interpreted as PI effect occurring at the periphery of plasma column, however in the low field side where the LH power is coupled.

  17. Hybrid photomultiplier tube and photodiode parallel detection array for wideband optical spectroscopy of the breast guided by magnetic resonance imaging

    PubMed Central

    Mastanduno, Michael A.; Jiang, Shudong; Pogue, Brian W.; Paulsen, Keith D.

    2013-01-01

    Abstract. A new optical parallel detection system of hybrid frequency and continuous-wave domains was developed to improve the data quality and accuracy in recovery of all breast optical properties. This new system was deployed in a previously existing system for magnetic resonance imaging (MRI)-guided spectroscopy, and allows incorporation of additional near-infrared wavelengths beyond 850 nm, with interlaced channels of photomultiplier tubes (PMTs) and silicon photodiodes (PDs). The acquisition time for obtaining frequency-domain data at six wavelengths (660, 735, 785, 808, 826, and 849 nm) and continuous-wave data at three wavelengths (903, 912, and 948 nm) is 12 min. The dynamic ranges of the detected signal are 105 and 106 for PMT and PD detectors, respectively. Compared to the previous detection system, the SNR ratio of frequency-domain detection was improved by nearly 103 through the addition of an RF amplifier and the utilization of programmable gain. The current system is being utilized in a clinical trial imaging suspected breast cancer tumors as detected by contrast MRI scans. PMID:23979460

  18. Hybrid photomultiplier tube and photodiode parallel detection array for wideband optical spectroscopy of the breast guided by magnetic resonance imaging.

    PubMed

    El-Ghussein, Fadi; Mastanduno, Michael A; Jiang, Shudong; Pogue, Brian W; Paulsen, Keith D

    2014-01-01

    A new optical parallel detection system of hybrid frequency and continuous-wave domains was developed to improve the data quality and accuracy in recovery of all breast optical properties. This new system was deployed in a previously existing system for magnetic resonance imaging (MRI)-guided spectroscopy, and allows incorporation of additional near-infrared wavelengths beyond 850 nm, with interlaced channels of photomultiplier tubes (PMTs) and silicon photodiodes (PDs). The acquisition time for obtaining frequency-domain data at six wavelengths (660, 735, 785, 808, 826, and 849 nm) and continuous-wave data at three wavelengths (903, 912, and 948 nm) is 12 min. The dynamic ranges of the detected signal are 105 and 106 for PMT and PD detectors, respectively. Compared to the previous detection system, the SNR ratio of frequency-domain detection was improved by nearly 103 through the addition of an RF amplifier and the utilization of programmable gain. The current system is being utilized in a clinical trial imaging suspected breast cancer tumors as detected by contrast MRI scans. PMID:23979460

  19. X-ray emission current scaling experiments for compact single-tungsten-wire arrays at 80-nanosecond implosion times.

    PubMed

    Mazarakis, Michael G; Cuneo, Michael E; Stygar, William A; Harjes, Henry C; Sinars, Daniel B; Jones, Brent M; Deeney, Christopher; Waisman, Eduardo M; Nash, Thomas J; Struve, Kenneth W; McDaniel, Dillon H

    2009-01-01

    We report the results of a series of current scaling experiments with the Z accelerator for the compact, single, 20-mm diameter, 10-mm long, tungsten-wire arrays employed for the double-ended hohlraum ICF concept [M. E. Cuneo, Plasma Phys. Controlled Fusion 48, R1 (2006)]. We measured the z -pinch peak radiated x-ray power and total radiated x-ray energy as a function of the peak current, at a constant implosion time tau_{imp}=80ns . Previous x-ray emission current scaling for these compact arrays was obtained at tau_{imp}=95ns in the work of Stygar [Phys. Rev. E 69, 046403 (2004)]. In the present study we utilized lighter single-tungsten-wire arrays. For all the measurements, the load hardware dimensions, materials, and array wire number (N=300) were kept constant and were the same as the previous study. We also kept the normalized load current spatial and temporal profiles the same for all experiments reported in this work. Two different currents, 11.2+/-0.2MA and 17.0+/-0.3MA , were driven through the wire arrays. The average peak x-ray power for these compact wire arrays increased by 26%+/-7%to158+/-26TW at 17+/-0.3MA from the 125+/-24TW obtained at a peak current of 18.8+/-0.5MA with tau_{imp}=95ns . The higher peak power of the faster implosions may possibly be attributed to a higher implosion velocity, which in turn improves the implosion stability, and/or to shorter wire ablation times, which may lead to a decrease in trailing mass and trailing current. Our results show that the scaling of the radiated x-ray peak power and total radiated x-ray energy scaling with peak drive current to be closer to quadratic than the results of Stygar We find that the x-ray peak radiated power is P_{r} proportional, variantI;{1.57+/-0.20} and the total x-ray radiated energy E_{r} proportional, variantI;{1.9+/-0.24} . We also find that the current scaling exponent of the power is sensitive to the inclusion of a single data point with a peak power at least 1.9sigma below the

  20. L-Band Ionosphere Scintillations Observed by A Spaced GPS Receiver Array during Recent Active Experiments at HAARP

    NASA Astrophysics Data System (ADS)

    Morton, Y.; Pelgrum, W.; van Graas, F.; Gunawardena, S.; Charney, D.; Peng, S.; Triplett, J.; Vikram, P.; Vemuru, A.

    2010-12-01

    L-Band Ionosphere Scintillations Observed by A Spaced GPS Receiver Array during Recent Active Experiments at HAARP Jade Morton*, Wouter Pelgrum**, Sanjeev Gunawardena**, Frank van Graas**, Dan Charney*, Senlin Peng***, Jeff Triplett*, Ajay Vemuru** * Department of Electrical and Computer Engineering, Miami University ** Avionics Engineering Center, Ohio University *** Department of Electrical and Computer Engineering, Virginia Tech Ionosphere irregularities can cause scintillation of satellite-based radio communication, navigation, and surveillance signals. While these scintillation effects will impact the corresponding receiver and system performance, carefully recovered signal parameters serve as a means of studying the background state and dynamics of the ionosphere. In this presentation, we will describe our recent effort in establishing a unique spaced GNSS receiver array at HAARP, Alaska to collect GPS and GLONASS satellite signals at various stages of the GNSS receiver processing. Preliminary receiver processing results as well as additional on-site diagnostic instrumentation measurements obtained from two active heating experiment campaigns will be presented to demonstrate the feasibility and effectiveness of our experimental data collection system in providing insightful details of ionosphere responses to active perturbations.

  1. The International Telecommunications Satellite (INTELSAT) Solar Array Coupon (ISAC) atomic oxgyen flight experiment: Techniques, results and summary

    NASA Technical Reports Server (NTRS)

    Koontz, S.; King, G.; Dunnet, A.; Kirkendahl, T.; Linton, R.; Vaughn, J.

    1993-01-01

    Techniques and results of the ISAC flight experiment are presented, and comparisons between flight tests results and ground based testing are made. The ISAC flight experiment, one component of a larger INTELSAT 6 rescue program, tested solar array configurations and individual silver connects in ground based facilities and during STS-41 (Space Shuttle Discovery). In addition to the INTELSAT specimens, several materials, for which little or no flight data exist, were also tested for atomic oxygen reactivity. Dry lubricants, elastomers, polymeric materials, and inorganic materials were exposed to an oxygen atom fluence of 1.2 x 10(exp 20) atoms. Many of the samples were selected to support Space Station Freedom design and decision-making.

  2. Operation of a multiple cell array detector in plasma experiments with a heavy ion beam diagnostic

    SciTech Connect

    Goncalves, B.; Malaquias, A.; Nedzelskiy, I. S.; Pereira, L.; Silva, C.; Varandas, C.A.F.; Cabral, J.A.C.; Khrebtov, S.M.; Dreval, N.B.; Krupnik, L.I.; Hidalgo, C.; Depablos, J.

    2004-10-01

    A multiple cell array detector (MCAD) has been developed to investigate the spatial structure of plasma turbulence in fusion plasmas. This system is expected to provide simultaneous measurements of edge and core density fluctuations with both temporal and spatial resolution, extending the range and number of the sample volumes simultaneously recorded by a heavy ion beam diagnostic (HIBD). Since the detector (usually located close to the vessel wall of a plasma device) operates in a strong plasma radiation environment, the effective shielding of the detector presents a special problem. This article describes and compares the MCAD operation conditions on ISTTOK tokamak and TJ-II stellarator. Experimental results of the detector performance are presented together with the first measurements of n{sub e}{sigma}{sub eff} in the TJ-II plasmas.

  3. The Murchison Widefield Array 21cm Epoch of Reionization Experiment: Design, Construction, and First Season Results

    NASA Astrophysics Data System (ADS)

    Beardsley, Adam

    The Cosmic Dark Ages and the Epoch of Reionization (EoR) remain largely unexplored chapters in the history and evolution of the Universe. These periods hold the potential to inform our picture of the cosmos similar to what the Cosmic Microwave Background has done over the past several decades. A promising method to probe the neutral hydrogen gas between early galaxies is known as 21cm tomography, which utilizes the ubiquitous hyper-fine transition of HI to create 3D maps of the intergalactic medium. The Murchison Widefield Array (MWA) is an instrument built with a primary science driver to detect and characterize the EoR through 21cm tomography. In this thesis we explore the challenges faced by the MWA from the layout of antennas, to a custom analysis pipeline, to bridging the gap with probes at other wavelengths. We discuss many lessons learned in the course of reducing MWA data with an extremely precise measurement in mind, and conclude with the first deep integration from array. We present a 2-σ upper limit on the EoR power spectrum of Δ^2(k)<1.25×10^4 mK^2 at cosmic scale k=0.236 h Mpc^{-1} and redshift z=6.8. Our result is a marginal improvement over previous MWA results and consistent with the best published limits from other instruments. This result is the deepest imaging power spectrum to date, and is a major step forward for this type of analysis. While our limit is dominated by systematics, we offer strategies for improvement for future analysis.

  4. The Murchison Widefield Array 21cm Epoch of Reionization Experiment: Design, Construction, and First Season Results

    NASA Astrophysics Data System (ADS)

    Beardsley, Adam

    The Cosmic Dark Ages and the Epoch of Reionization (EoR) remain largely unexplored chapters in the history and evolution of the Universe. These periods hold the potential to inform our picture of the cosmos similar to what the Cosmic Microwave Background has done over the past several decades. A promising method to probe the neutral hydrogen gas between early galaxies is known as 21cm tomography, which utilizes the ubiquitous hyper-fine transition of HI to create 3D maps of the intergalactic medium. The Murchison Widefield Array (MWA) is an instrument built with a primary science driver to detect and characterize the EoR through 21cm tomography. In this thesis we explore the challenges faced by the MWA from the layout of antennas, to a custom analysis pipeline, to bridging the gap with probes at other wavelengths. We discuss many lessons learned in the course of reducing MWA data with an extremely precise measurement in mind, and conclude with the first deep integration from array. We present a 2-sigma upper limit on the EoR power spectrum of Delta2(k) < 1.25 x 104 mK2 at cosmic scale k = 0.236 h Mpc-1 and redshift z = 6.8. Our result is a marginal improvement over previous MWA results and consistent with the best published limits from other instruments. This result is the deepest imaging power spectrum to date, and is a major step forward for this type of analysis. While our limit is dominated by systematics, we offer strategies for improvement for future analysis.

  5. Somatic alterations in the melanoma genome: a high-resolution array-based comparative genomic hybridization study.

    PubMed

    Gast, Andreas; Scherer, Dominique; Chen, Bowang; Bloethner, Sandra; Melchert, Stephanie; Sucker, Antje; Hemminki, Kari; Schadendorf, Dirk; Kumar, Rajiv

    2010-08-01

    We performed DNA microarray-based comparative genomic hybridization to identify somatic alterations specific to melanoma genome in 60 human cell lines from metastasized melanoma and from 44 corresponding peripheral blood mononuclear cells. Our data showed gross but nonrandom somatic changes specific to the tumor genome. Although the CDKN2A (78%) and PTEN (70%) loci were the major targets of mono-allelic and bi-allelic deletions, amplifications affected loci with BRAF (53%) and NRAS (12%) as well as EGFR (52%), MITF (40%), NOTCH2 (35%), CCND1 (18%), MDM2 (18%), CCNE1 (10%), and CDK4 (8%). The amplified loci carried additional genes, many of which could potentially play a role in melanoma. Distinct patterns of copy number changes showed that alterations in CDKN2A tended to be more clustered in cell lines with mutations in the BRAF and NRAS genes; the PTEN locus was targeted mainly in conjunction with BRAF mutations. Amplification of CCND1, CDK4, and other loci was significantly increased in cell lines without BRAF-NRAS mutations and so was the loss of chromosome arms 13q and 16q. Our data suggest involvement of distinct genetic pathways that are driven either through oncogenic BRAF and NRAS mutations complemented by aberrations in the CDKN2A and PTEN genes or involve amplification of oncogenic genomic loci and loss of 13q and 16q. It also emerges that each tumor besides being affected by major and most common somatic genetic alterations also acquires additional genetic alterations that could be crucial in determining response to small molecular inhibitors that are being currently pursued. PMID:20544847

  6. Xq26.1-26.2 gain identified on array comparative genomic hybridization in bilateral periventricular nodular heterotopia with overlying polymicrogyria.

    PubMed

    Abe, Yu; Kikuchi, Atsuo; Kobayashi, Satoru; Wakusawa, Keisuke; Tanaka, Soichiro; Inui, Takehiko; Kunishima, Shinji; Kure, Shigeo; Haginoya, Kazuhiro

    2014-12-01

    Periventricular nodular heterotopia (PNH) with overlying polymicrogyria (PMG) is a recently described, developmental brain malformation; however, the causative genes of this malformation have not yet been identified. We report on a 5-year-old Japanese male with bilateral PNH with overlying PMG. He had mild intellectual disability, distinctive facial features, short stature, and microcephaly, with cardiac disorders. No mutation was identified in Sanger sequences for FLNA and ARFGEF2; however, array comparative genomic hybridization revealed an approximately 0.8Mb gain at Xq26.1-26.2, which included three genes: IGSF1, OR13H1, and FIRRE. We identified the same 3-copy gain in his mother; despite identifying the same abnormality in the mother, it must still be considered as a possible cause for the abnormalities, as X-inactivation in the mother could have led to her not expressing the same phenotype. This case may provide important clues for identifying the genes responsible and help in the understanding of the pathogenesis of this disorder. PMID:25052774

  7. Array-based comparative genomic hybridization in early-stage mycosis fungoides: recurrent deletion of tumor suppressor genes BCL7A, SMAC/DIABLO, and RHOF.

    PubMed

    Carbone, Angelo; Bernardini, Laura; Valenzano, Francesco; Bottillo, Irene; De Simone, Clara; Capizzi, Rodolfo; Capalbo, Anna; Romano, Francesca; Novelli, Antonio; Dallapiccola, Bruno; Amerio, Pierluigi

    2008-12-01

    The etiology of mycosis fungoides (MF), the most frequent form of cutaneous T cell lymphoma (CTCL), is poorly understood. No specific genetic aberration has been detected, especially in early-stage disease, possibly due to the clinical and histological heterogeneity of patient series and to the different sources of malignant cells (skin, blood, or lymph node) included in most studies. Frozen skin biopsies from 16 patients with early-stage MF were studied using array-based comparative genomic hybridization. A DNA pool from healthy donors was used as the reference. Results demonstrated recurrent loss of 19, 7p22.1-p22.3, 7q11.1-q11.23, 9q34.12, 12q24.31, and 16q22.3-q23.1, and gain of 8q22.3-q23.1 and 21q22.12. The 12q24.31 region was recurrently deleted in 7/16 patients. Real-time PCR investigation for deletion of genes BCL7A, SMAC/DIABLO, and RHOF-three tumor suppressor genes with a putative role in hematological malignancies-demonstrated that they were deleted in 9, 10, and 13 cases, respectively. The identified genomic alterations and individual genes could yield important insights into the early steps of MF pathogenesis. PMID:18663754

  8. Risk assessment models in genetics clinic for array comparative genomic hybridization: Clinical information can be used to predict the likelihood of an abnormal result in patients

    PubMed Central

    Marano, Rachel M.; Mercurio, Laura; Kanter, Rebecca; Doyle, Richard; Abuelo, Dianne; Morrow, Eric M.; Shur, Natasha

    2013-01-01

    Array comparative genomic hybridization (aCGH) testing can diagnose chromosomal microdeletions and duplications too small to be detected by conventional cytogenetic techniques. We need to consider which patients are more likely to receive a diagnosis from aCGH testing versus patients that have lower likelihood and may benefit from broader genome wide scanning. We retrospectively reviewed charts of a population of 200 patients, 117 boys and 83 girls, who underwent aCGH testing in Genetics Clinic at Rhode Island hospital between 1 January/2008 and 31 December 2010. Data collected included sex, age at initial clinical presentation, aCGH result, history of seizures, autism, dysmorphic features, global developmental delay/intellectual disability, hypotonia and failure to thrive. aCGH analysis revealed abnormal results in 34 (17%) and variants of unknown significance in 24 (12%). Patients with three or more clinical diagnoses had a 25.0% incidence of abnormal aCGH findings, while patients with two or fewer clinical diagnoses had a 12.5% incidence of abnormal aCGH findings. Currently, we provide families with a range of 10–30% of a diagnosis with aCGH testing. With increased clinical complexity, patients have an increased probability of having an abnormal aCGH result. With this, we can provide individualized risk estimates for each patient.

  9. Targeted array comparative genomic hybridization--a new diagnostic tool for the detection of large copy number variations in nemaline myopathy-causing genes.

    PubMed

    Kiiski, K; Laari, L; Lehtokari, V-L; Lunkka-Hytönen, M; Angelini, C; Petty, R; Hackman, P; Wallgren-Pettersson, C; Pelin, K

    2013-01-01

    Nemaline myopathy (NM) constitutes a heterogeneous group of congenital myopathies. Mutations in the nebulin gene (NEB) are the main cause of recessively inherited NM. NEB is one of the most largest genes in human. To date, 68 NEB mutations, mainly small deletions or point mutations have been published. The only large mutation characterized is the 2.5 kb deletion of exon 55 in the Ashkenazi Jewish population. To investigate any copy number variations in this enormous gene, we designed a novel custom comparative genomic hybridization microarray, NM-CGH, targeted towards the seven known genes causative for NM. During the validation of the NM-CGH array we identified two novel deletions in two different families. The first is the largest deletion characterized in NEB to date, (∼53 kb) encompassing 24 exons. The second deletion (1 kb) covers two exons. In both families, the copy number change was the second mutation to be characterized and shown to have been inherited from one of the healthy carrier parents. In addition to these novel mutations, copy number variation was identified in four samples in three families in the triplicate region of NEB. We conclude that this method appears promising for the detection of copy number variations in NEB. PMID:23010307

  10. Prenatal diagnosis of Wolf-Hirschhorn syndrome confirmed by comparative genomic hybridization array: report of two cases and review of the literature.

    PubMed

    Sifakis, Stavros; Manolakos, Emmanouil; Vetro, Annalisa; Kappou, Dimitra; Peitsidis, Panagiotis; Kontodiou, Maria; Garas, Antonios; Vrachnis, Nikolaos; Konstandinidou, Anastasia; Zuffardi, Orsetta; Orru, Sandro; Papoulidis, Ioannis

    2012-01-01

    Wolf-Hirschhorn syndrome (WHS) is a well known genetic condition caused by a partial deletion of the short arm of chromosome 4. The great variability in the extent of the 4p deletion and the possible contribution of additional genetic rearrangements lead to a wide spectrum of clinical manifestations. The majority of the reports of prenatally diagnosed WHS cases are associated with large 4p deletions identified by conventional chromosome analysis; however, the widespread clinical use of novel molecular techniques such as array comparative genomic hybridization (a-CGH) has increased the detection rate of submicroscopic chromosomal aberrations associated with WHS phenotype. We provide a report of two fetuses with WHS presenting with intrauterine growth restriction as an isolated finding or combined with oligohydramnios and abnormal Doppler waveform in umbilical artery and uterine arteries. Standard karyotyping demonstrated a deletion on chromosome 4 in both cases [del(4)(p15.33) and del(4)(p15.31), respectively] and further application of a-CGH confirmed the diagnosis and offered a precise characterization of the genetic defect. A detailed review of the currently available literature on the prenatal diagnostic approach of WHS in terms of fetal sonographic assessment and molecular cytogenetic investigation is also provided. PMID:22373435

  11. Microfluidic Integration of a Cloth-Based Hybridization Array System (CHAS) for Rapid, Colorimetric Detection of Enterohemorrhagic Escherichia coli (EHEC) Using an Articulated, Centrifugal Platform.

    PubMed

    Geissler, Matthias; Clime, Liviu; Hoa, Xuyen D; Morton, Keith J; Hébert, Harold; Poncelet, Lucas; Mounier, Maxence; Deschênes, Mylène; Gauthier, Martine E; Huszczynski, George; Corneau, Nathalie; Blais, Burton W; Veres, Teodor

    2015-10-20

    We describe the translation of a cloth-based hybridization array system (CHAS), a colorimetric DNA detection method that is used by food inspection laboratories for colony screening of pathogenic agents, onto a microfluidic chip format. We also introduce an articulated centrifugal platform with a novel fluid manipulation concept based on changes in the orientation of the chip with respect to the centrifugal force field to time the passage of multiple components required for the process. The platform features two movable and motorized carriers that can be reoriented on demand between 0 and 360° during stage rotation. Articulation of the chip can be used to trigger on-the-fly fluid dispensing through independently addressable siphon structures or to relocate solutions against the centrifugal force field, making them newly accessible for downstream transfer. With the microfluidic CHAS, we achieved significant reduction in the size of the cloth substrate as well as the volume of reagents and wash solutions. Both the chip design and the operational protocol were optimized to perform the entire process in a reliable, fully automated fashion. A demonstration with PCR-amplified genomic DNA confirms on-chip detection and identification of Escherichia coli O157:H7 from colony isolates in a colorimetric multiplex assay using rfbO157, fliCH7, vt1, and vt2 genes. PMID:26416260

  12. Prenatal diagnosis of a partial trisomy 13q (q14-->qter): phenotype, cytogenetics and molecular characterization by spectral karyotyping and array comparative genomic hybridization.

    PubMed

    Machado, I N; Heinrich, J K; Campanhol, C; Rodrigues-Peres, R M; Oliveira, F M; Barini, R

    2010-01-01

    Partial trisomy 13q is an uncommon chromosomal abnormality with variable phenotypic expression. We report prenatal diagnosis of partial trisomy 13q in a fetus with partial agenesis of the cerebellar vermis, partial agenesis of the corpus callosum, hydrops and polyhydramnios. G-banding karyotyping, spectral karyotyping and array comparative genomic hybridization (aCGH) analysis of fetal blood were performed. Cytogenetic analysis of fetal blood displayed 46,XX,add(4)(q28). The parental karyotypes were normal. A girl was delivered at 34 weeks gestation; she died within 2 h. Autopsy confirmed all the prenatal findings and also showed agenesis of the diaphragm. Spectral karyotyping identified the additional material's origin as chromosome 13. aCGH was carried out and showed amplification of distal regions of the long arm of chromosome 13 from region 13q14 to qter. This is the first report of a fetus with molecular characterization of a partial trisomy 13q (q14-->qter), present as a de novo unbalanced translocation at chromosome 4q. This case demonstrates the usefulness of molecular characterization of malformed fetuses for prenatal diagnosis and counseling. PMID:20391329

  13. Application of Sequence-Specific Labeled 16S rRNA Gene Oligonucleotide Probes for Genetic Profiling of Cyanobacterial Abundance and Diversity by Array Hybridization

    PubMed Central

    Rudi, Knut; Skulberg, Olav M.; Skulberg, Randi; Jakobsen, Kjetill S.

    2000-01-01

    DNA sequence information for the small-subunit rRNA gene (16S rDNA) obtained from cyanobacterial cultures was used to investigate the presence of cyanobacteria and their abundance in natural habitats. Eight planktonic communities developing in lakes characterized by relatively low algal biomass (mesotrophic) and in lakes with correspondingly high biomass (eutrophic) were selected for the study. The organismal compositions of the water samples were analyzed genetically, using multiplex sequence-specific labeling of oligonucleotide probes targeted to 16S rDNA and subsequent hybridization of the labeled probes to their respective complements spotted onto a solid support (DNA array). Ten probes were established to determine the relative abundances of the discernible cyanobacteria encountered in the selected lakes. The probes were generally specific for their targets, as determined through analyses of clone cultures. Reproducible abundance profiles were established for the lakes investigated in the subsequent analyses of natural cyanobacterial communities. The results from the genetic analyses were then compared with information obtained from standard hydrobiological and hydrochemical analyses. Qualitatively, there were relatively good correlations among the groups of organisms (Nostoc, Microcystis, and Planktothrix species) found in the different lakes. The levels of correlation were lower for the quantitative data. This may, however, be due to differences in sample processing technique. The conclusions from these comparisons are that the genetic abundance profiles may provide a foundation for separating and quantifying genetically distinct groups of cyanobacteria in their natural habitats. PMID:10966421

  14. TiO2 nanotube array photoelectrocatalyst and Ni-Sb-SnO2 electrocatalyst bifacial electrodes: a new type of bifunctional hybrid platform for water treatment.

    PubMed

    Yang, So Young; Choi, Wonyong; Park, Hyunwoong

    2015-01-28

    Bifunctional hybrid electrodes capable of generating various reactive oxygen species (ROS) over a wide range of potentials were developed by coupling electrocatalysts and photoelectrocatalysts. To achieve this, Ni-doped Sb-SnO2 (NSS) was deposited on one side of a titanium (Ti) foil while the other side was anodized to grow a TiO2 nanotube array (TNA) for electrochemical ozone generation and photoelectrochemical hydroxyl radical generation, respectively. Surface characterization indicated that NSS and TNA were formed and spatially separated yet electrically connected through the Ti substrate. While each catalyst possessed unique electrochemical properties, the coupling of both catalysts resulted in mixed electrochemical properties that drove electrocatalysis at high potentials and photoelectrocatalysis at low potentials. The performance of the NSS/TNA electrode for phenol decomposition was ∼3 times greater than that of single-layer catalysts and ∼1.5 times greater than the combined catalytic performances of the individual NSS and TNA catalysts. This synergistic effect was attributed partly to the simultaneous generation of hydroxyl radicals and ozone, followed by the production of other ROS. A mechanism for the generation of ROS was discussed. PMID:25561436

  15. Array comparative genomic hybridization identifies a distinct DNA copy number profile in renal cell cancer associated with hereditary leiomyomatosis and renal cell cancer.

    PubMed

    Koski, Taru A; Lehtonen, Heli J; Jee, Kowan J; Ninomiya, Shinsuke; Joosse, Simon A; Vahteristo, Pia; Kiuru, Maija; Karhu, Auli; Sammalkorpi, Heli; Vanharanta, Sakari; Lehtonen, Rainer; Edgren, Henrik; Nederlof, Petra M; Hietala, Marja; Aittomäki, Kristiina; Herva, Riitta; Knuutila, Sakari; Aaltonen, Lauri A; Launonen, Virpi

    2009-07-01

    Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a tumor predisposition syndrome with cutaneous and uterine leiomyomatosis as well as renal cell cancer (RCC) as its clinical manifestations. HLRCC is caused by heterozygous germline mutations in the fumarate hydratase (fumarase) gene. In this study, we used array comparative genomic hybridization to identify the specific copy number changes characterizing the HLRCC-associated RCCs. The study material comprised formalin-fixed paraffin-embedded renal tumors obtained from Finnish patients with HLRCC. All 11 investigated tumors displayed the papillary type 2 histopathology typical for HLRCC renal tumors. The most frequent copy number changes detected in at least 3/11 (27%) of the tumors were gains in chromosomes 2, 7, and 17, and losses in 13q12.3-q21.1, 14, 18, and X. These findings provide genetic evidence for a distinct copy number profile in HLRCC renal tumors compared with sporadic RCC tumors of the same histopathological subtype, and delineate chromosomal regions that associate with this very aggressive form of RCC. PMID:19373782

  16. An Xq22.3 duplication detected by comparative genomic hybridization microarray (Array-CGH) defines a new locus (FGS5) for FG syndrome.

    PubMed

    Jehee, Fernanda Sarquis; Rosenberg, Carla; Krepischi-Santos, Ana Cristina; Kok, Fernando; Knijnenburg, Jeroen; Froyen, Guy; Vianna-Morgante, Angela M; Opitz, John M; Passos-Bueno, Maria Rita

    2005-12-15

    FG syndrome is an X-linked multiple congenital anomalies (MCA) syndrome. It has been mapped to four distinct loci FGS1-4, through linkage analysis (Xq13, Xp22.3, and Xp11.4-p11.3) and based on the breakpoints of an X chromosome inversion (Xq11:Xq28), but so far no gene has been identified. We describe a boy with FG syndrome who has an inherited duplication at band Xq22.3 detected by comparative genomic hybridization microarray (Array-CGH). These duplication maps outside all four loci described so far for FG syndrome, representing therefore a new locus, which we propose to be called FGS5. MID2, a gene closely related to MID1, which is known to be mutated in Opitz G/BBB syndrome, maps within the duplicated segment of our patient. Since FG and Opitz G/BBB syndromes share many manifestations we considered MID2 a candidate gene for FG syndrome. We also discuss the involvement of other potential genes within the duplicated segment and its relationship with clinical symptoms of our patient, as well as the laboratory abnormalities found in his mother, a carrier of the duplication. PMID:16283679

  17. Rapid prenatal diagnosis of chromosomal aneuploidies by fluorescence in situ hybridization: Clinical experience with 4,500 specimens

    SciTech Connect

    Ward, B.E.; Gersen, S.L.; Carelli, M.P.; McGuire, N.M.; Dackowski, W.R.; Klinger, K.W. ); Weinstein, M. ); Sandlin, C. ); Klinger, K.W. )

    1993-05-01

    Detection of chromosome aneuploidies in uncultured amniocytes is possible using fluorescence in situ hybridization (FISH). The authors herein describe the results of the first clinical program which utilized FISH for the rapid detection of chromosome aneuploidies in uncultured amniocytes. FISH was performed on physician request, as an adjunct to cytogenetics in 4,500 patients. Region-specific DNA probes to chromosomes 13, 18, 21, X, and Y were used to determine ploidy by analysis of signal number in hybridized nuclei. A sample was considered to be euploid when all autosomal probes generated two hybridization signals and when a normal sex chromosome pattern was observed in greater than or equal to 80% of hybridized nuclei. A sample was considered to be aneuploid when greater than or equal to 70% of hybridized nuclei displayed the same abnormal hybridization pattern for a specific probe. Of the attempted analyses, 90.2% met these criteria and were reported as informative to referring physicians within 2 d of receipt. Based on these reporting parameters, the overall detection rate for aneuploidies was 73.3% (107/146), with an accuracy of informative results for aneuploidies of 93.9% (107/114). Compared to cytogenetics, the accuracy of all informative FISH results, euploid and aneuploid, was 99.8%, and the specificity was 99.9%. In those pregnancies where fetal abnormalities had been observed by ultrasound, referring physicians requested FISH plus cytogenetics at a significantly higher rate than they requested cytogenetics alone. The current prenatal FISH protocol is not designed to detect all chromosome abnormalities and should only be utilized as an adjunctive test to cytogenetics. This experience demonstrates that FISH can provide a rapid and accurate clinical method for prenatal identification of chromosome aneuploidies. 40 refs., 1 fig., 5 tabs.,

  18. Rapid prenatal diagnosis of chromosomal aneuploidies by fluorescence in situ hybridization: clinical experience with 4,500 specimens.

    PubMed Central

    Ward, B E; Gersen, S L; Carelli, M P; McGuire, N M; Dackowski, W R; Weinstein, M; Sandlin, C; Warren, R; Klinger, K W

    1993-01-01

    Detection of chromosome aneuploidies in uncultured amniocytes is possible using fluorescence in situ hybridization (FISH). We herein describe the results of the first clinical program which utilized FISH for the rapid detection of chromosome aneuploidies in uncultured amniocytes. FISH was performed on physician request, as an adjunct to cytogenetics in 4,500 patients. Region-specific DNA probes to chromosomes 13, 18, 21, X, and Y were used to determine ploidy by analysis of signal number in hybridized nuclei. A sample was considered to be euploid when all autosomal probes generated two hybridization signals and when a normal sex chromosome pattern was observed in greater than or equal to 80% of hybridized nuclei. A sample was considered to be aneuploid when greater than or equal to 70% of hybridized nuclei displayed the same abnormal hybridization pattern for a specific probe. Of the attempted analyses, 90.2% met these criteria and were reported as informative to referring physicians within 2 d of receipt. Based on these reporting parameters, the overall detection rate for aneuploidies was 73.3% (107/146), with an accuracy of informative results for aneuploidies of 93.9% (107/114). Compared to cytogenetics, the accuracy of all informative FISH results, euploid and aneuploid, was 99.8%, and the specificity was 99.9%. In those pregnancies where fetal abnormalities had been observed by ultrasound, referring physicians requested FISH plus cytogenetics at a significantly higher rate than they requested cytogenetics alone. The current prenatal FISH protocol is not designed to detect all chromosome abnormalities and should only be utilized as an adjunctive test to cytogenetics. This experience demonstrates that FISH can provide a rapid and accurate clinical method for prenatal identification of chromosome aneuploidies. PMID:8488836

  19. Molecular marker-based prediction of hybrid performance in maize using unbalanced data from multiple experiments with factorial crosses.

    PubMed

    Schrag, Tobias A; Möhring, Jens; Maurer, Hans Peter; Dhillon, Baldev S; Melchinger, Albrecht E; Piepho, Hans-Peter; Sørensen, Anker P; Frisch, Matthias

    2009-02-01

    In hybrid breeding, the prediction of hybrid performance (HP) is extremely important as it is difficult to evaluate inbred lines in numerous cross combinations. Recent developments such as doubled haploid production and molecular marker technologies have enhanced the prospects of marker-based HP prediction to accelerate the breeding process. Our objectives were to (1) predict HP using a combined analysis of hybrids and parental lines from a breeding program, (2) evaluate the use of molecular markers in addition to phenotypic and pedigree data, (3) evaluate the combination of line per se data with marker-based estimates, (4) study the effect of the number of tested parents, and (5) assess the advantage of haplotype blocks. An unbalanced dataset of 400 hybrids from 9 factorial crosses tested in different experiments and data of 79 inbred parents were subjected to combined analyses with a mixed linear model. Marker data of the inbreds were obtained with 20 AFLP primer-enzyme combinations. Cross-validation was used to assess the performance prediction of hybrids of which no or only one parental line was testcross evaluated. For HP prediction, the highest proportion of explained variance (R (2)), 46% for grain yield (GY) and 70% for grain dry matter content (GDMC), was obtained from line per se best linear unbiased prediction (BLUP) estimates plus marker effects associated with mid-parent heterosis (TEAM-LM). Our study demonstrated that HP was efficiently predicted using molecular markers even for GY when testcross data of both parents are not available. This can help in improving greatly the efficiency of commercial hybrid breeding programs. PMID:19048224

  20. Large eddy simulations and experiments of nonlinear flow interactions in hybrid rocket combustion

    NASA Astrophysics Data System (ADS)

    Na, Y.; Lee, C.

    2013-03-01

    Nonlinear combustion phenomenon was investigated through an experiment in a hybrid rocket motor. A poly(methyl methacrylate) (PMMA) / gaseous oxygen (GOx) combination was used with several types of disks equipped in a prechamber with the aim of modifying the local turbulent flow. By allowing this disturbance generated in a prechamber to interact with the shedding vortex inherently produced in the main chamber, a possibility of commonly observed nonlinear combustion feature such as DC-shift was analyzed. In a baseline test, a vortex shedding occurs due to the interaction of a main oxidizer flow with the evaporated fuel stream coming out of the surface during the regression process. Among the several types of disks, it turned out that only the disk4 produced the excitation which subsequently suppressed the vortex shedding phenomenon in the main chamber. This descent interaction was reflected in a sudden pressure drop (which may be described as direct current (DC) shift) of about 10 psi in the time history of the pressure during the nominal combustion. The present result with the disk4 suggests the possibility of phase cancellation between the excitation induced by the disk4 and the shedding vortex but much more work should be conducted to extract more accurate correlation of the phase information. In order to understand the baseline flow physics, a compressible large eddy simulation (LES) was conducted with the prescribed wall blowing boundary condition. The result clearly exhibited the existence of vortex shedding phenomenon with a specified frequency. The fact that important flow features of the present computation are quite similar to those obtained with an incompressible assumption in a flat channel suggests that both compressibility and curvature effects do not dominate in the present flow configuration.

  1. Experiment on interface separation detection of concrete-filled steel tubular arch bridge using accelerometer array

    NASA Astrophysics Data System (ADS)

    Pan, Shengshan; Zhao, Xuefeng; Zhao, Hailiang; Mao, Jian

    2015-04-01

    Based on the vibration testing principle, and taking the local vibration of steel tube at the interface separation area as the study object, a real-time monitoring and the damage detection method of the interface separation of concrete-filled steel tube by accelerometer array through quantitative transient self-excitation is proposed. The accelerometers are arranged on the steel tube area with or without void respectively, and the signals of accelerometers are collected at the same time and compared under different transient excitation points. The results show that compared with the signal of compact area, the peak value of accelerometer signal at void area increases and attenuation speed slows down obviously, and the spectrum peaks of the void area are much more and disordered and the amplitude increases obviously. whether the input point of transient excitation is on void area or not is irrelevant with qualitative identification results. So the qualitative identification of the interface separation of concrete-filled steel tube based on the signal of acceleration transducer is feasible and valid.

  2. Quantum information experiments with 2D arrays of hundreds of trapped ions

    NASA Astrophysics Data System (ADS)

    Gilmore, Kevin; Bohnet, Justin; Sawyer, Brian; Britton, Joseph; Wall, Michael; Foss-Feig, Michael; Rey, Ana Maria; Bollinger, John

    2016-05-01

    We summarize recent experimental work with 2D arrays of hundreds of trapped 9 Be+ ions stored in a Penning trap. Penning traps utilize static magnetic and electric fields to confine ions, and enable the trapping and laser cooling of ion crystals larger than typically possible in RF ion traps. We work with single-plane ion crystals where the ions form a triangular lattice through minimization of their Coulomb potential energy. The crystals rotate, and we present numerical studies that determine optimal operating parameters for producing low temperature, stable 2-dimensional crystals with Doppler laser cooling and a rotating wall potential. Our qubit is the electron spin-flip transition in the ground state of 9 Be+ and is sensitive to magnetic field fluctuations. Through mitigation of part-per-billion, vibration-induced magnetic field fluctuations we demonstrate T2 coherence times longer than 50 ms. We engineer long-range Ising interactions with spin-dependent optical dipole forces, and summarize recent measurements that characterize the entanglement generated through single-axis twisting. Supported by: JILA-NSF-PFC-1125844, NSF-PHY-1521080, ARO, AFOSR, AFOSR-MURI.

  3. THE COSMIC-RAY ENERGY SPECTRUM OBSERVED WITH THE SURFACE DETECTOR OF THE TELESCOPE ARRAY EXPERIMENT

    SciTech Connect

    Abu-Zayyad, T.; Allen, M.; Anderson, R.; Barcikowski, E.; Belz, J. W.; Bergman, D. R.; Blake, S. A.; Cady, R.; Hanlon, W.; Aida, R.; Azuma, R.; Fukuda, T.; Cheon, B. G.; Cho, E. J.; Chiba, J.; Chikawa, M.; Cho, W. R.; Fujii, H.; Fujii, T.; Fukushima, M.; and others

    2013-05-01

    The Telescope Array (TA) collaboration has measured the energy spectrum of ultra-high energy cosmic rays (UHECRs) with primary energies above 1.6 Multiplication-Sign 10{sup 18} eV. This measurement is based upon four years of observation by the surface detector component of TA. The spectrum shows a dip at an energy of 4.6 Multiplication-Sign 10{sup 18} eV and a steepening at 5.4 Multiplication-Sign 10{sup 19} eV which is consistent with the expectation from the GZK cutoff. We present the results of a technique, new to the analysis of UHECR surface detector data, that involves generating a complete simulation of UHECRs striking the TA surface detector. The procedure starts with shower simulations using the CORSIKA Monte Carlo program where we have solved the problems caused by use of the ''thinning'' approximation. This simulation method allows us to make an accurate calculation of the acceptance of the detector for the energies concerned.

  4. SOLID2: An Antibody Array-Based Life-Detector Instrument in a Mars Drilling Simulation Experiment (MARTE)

    NASA Astrophysics Data System (ADS)

    Parro, Víctor; Fernández-Calvo, Patricia; Rodríguez Manfredi, José A.; Moreno-Paz, Mercedes; Rivas, Luis A.; García-Villadangos, Miriam; Bonaccorsi, Rosalba; González-Pastor, José Eduardo; Prieto-Ballesteros, Olga; Schuerger, Andrew C.; Davidson, Mark; Gómez-Elvira, Javier; Stoker, Carol R.

    2008-10-01

    A field prototype of an antibody array-based life-detector instrument, Signs Of LIfe Detector (SOLID2), has been tested in a Mars drilling mission simulation called MARTE (Mars Astrobiology Research and Technology Experiment). As one of the analytical instruments on the MARTE robotic drilling rig, SOLID2 performed automatic sample processing and analysis of ground core samples (0.5 g) with protein microarrays that contained 157 different antibodies. Core samples from different depths (down to 5.5 m) were analyzed, and positive reactions were obtained in antibodies raised against the Gram-negative bacterium Leptospirillum ferrooxidans, a species of the genus Acidithiobacillus (both common microorganisms in the Río Tinto area), and extracts from biofilms and other natural samples from the Río Tinto area. These positive reactions were absent when the samples were previously subjected to a high-temperature treatment, which indicates the biological origin and structural dependency of the antibody-antigen reactions. We conclude that an antibody array-based life-detector instrument like SOLID2 can detect complex biological material, and it should be considered as a potential analytical instrument for future planetary missions that search for life.

  5. 2D Radiation MHD K-shell Modeling of Single Wire Array Stainless Steel Experiments on the Z Machine

    SciTech Connect

    Thornhill, J. W.; Giuliani, J. L.; Apruzese, J. P.; Chong, Y. K.; Davis, J.; Dasgupta, A.; Whitney, K. G.; Clark, R. W.; Jones, B.; Coverdale, C. A.; Ampleford, D. J.; Cuneo, M. E.; Deeney, C.

    2009-01-21

    Many physical effects can produce unstable plasma behavior that affect K-shell emission from arrays. Such effects include: asymmetry in the initial density profile, asymmetry in power flow, thermal conduction at the boundaries, and non-uniform wire ablation. Here we consider how asymmetry in the radiation field also contributes to the generation of multidimensional plasma behavior that affects K-shell power and yield. To model this radiation asymmetry, we have incorporated into the MACH2 r-z MHD code a self-consistent calculation of the non-LTE population kinetics based on radiation transport using multi-dimensional ray tracing. Such methodology is necessary for modeling the enhanced radiative cooling that occurs at the anode and cathode ends of the pinch during the run-in phase of the implosion. This enhanced radiative cooling is due to reduced optical depth at these locations producing an asymmetric flow of radiative energy that leads to substantial disruption of large initial diameter (>5 cm) pinches and drives 1D into 2D fluid (i.e., Rayleigh-Taylor like) flows. The impact of this 2D behavior on K-shell power and yield is investigated by comparing 1D and 2D model results with data obtained from a series of single wire array stainless steel experiments performed on the Z generator.

  6. SOLID2: an antibody array-based life-detector instrument in a Mars Drilling Simulation Experiment (MARTE).

    PubMed

    Parro, Víctor; Fernández-Calvo, Patricia; Rodríguez Manfredi, José A; Moreno-Paz, Mercedes; Rivas, Luis A; García-Villadangos, Miriam; Bonaccorsi, Rosalba; González-Pastor, José Eduardo; Prieto-Ballesteros, Olga; Schuerger, Andrew C; Davidson, Mark; Gómez-Elvira, Javier; Stoker, Carol R

    2008-10-01

    A field prototype of an antibody array-based life-detector instrument, Signs Of LIfe Detector (SOLID2), has been tested in a Mars drilling mission simulation called MARTE (Mars Astrobiology Research and Technology Experiment). As one of the analytical instruments on the MARTE robotic drilling rig, SOLID2 performed automatic sample processing and analysis of ground core samples (0.5 g) with protein microarrays that contained 157 different antibodies. Core samples from different depths (down to 5.5 m) were analyzed, and positive reactions were obtained in antibodies raised against the Gram-negative bacterium Leptospirillum ferrooxidans, a species of the genus Acidithiobacillus (both common microorganisms in the Río Tinto area), and extracts from biofilms and other natural samples from the Río Tinto area. These positive reactions were absent when the samples were previously subjected to a high-temperature treatment, which indicates the biological origin and structural dependency of the antibody-antigen reactions. We conclude that an antibody array-based life-detector instrument like SOLID2 can detect complex biological material, and it should be considered as a potential analytical instrument for future planetary missions that search for life. PMID:19105755

  7. A scintillating bolometer array for double beta decay studies: The LUCIFER experiment

    NASA Astrophysics Data System (ADS)

    Gironi, L.

    2016-07-01

    The main goal of the LUCIFER experiment is to study the neutrinoless double beta decay, a rare process allowed if neutrinos are Majorana particles. Although aiming at a discovery, in the case of insufficient sensitivity the LUCIFER technique will be the demonstrator for a higher mass experiment able to probe the entire inverted hierarchy region of the neutrino mass. In order to achieve this challenging result, high resolution detectors with active background discrimination capability are required. This very interesting possibility can be largely fulfilled by scintillating bolometers thanks to the simultaneous read-out of heat and light emitted by the interactions in the detector or by pulse shape analysis.

  8. Design and coverage of high throughput genotyping arrays optimized for individuals of East Asian, African American, and Latino race/ethnicity using imputation and a novel hybrid SNP selection algorithm

    PubMed Central

    Hoffmann, Thomas J.; Zhan, Yiping; Kvale, Mark N.; Hesselson, Stephanie E.; Gollub, Jeremy; Iribarren, Carlos; Lu, Yontao; Mei, Gangwu; Purdy, Matthew M.; Quesenberry, Charles; Rowell, Sarah; Shapero, Michael H.; Smethurst, David; Somkin, Carol P.; Van den Eeden, Stephen K.; Walter, Larry; Webster, Teresa; Whitmer, Rachel A.; Finn, Andrea; Schaefer, Catherine; Kwok, Pui-Yan; Risch, Neil

    2012-01-01

    Four custom Axiom genotyping arrays were designed for a genome-wide association (GWA) study of 100,000 participants from the Kaiser Permanente Research Program on Genes, Environment and Health. The array optimized for individuals of European race/ethnicity was previously described. Here we detail the development of three additional microarrays optimized for individuals of East Asian, African American, and Latino race/ethnicity. For these arrays, we decreased redundancy of high-performing SNPs to increase SNP capacity. The East Asian array was designed using greedy pairwise SNP selection. However, removing SNPs from the target set based on imputation coverage is more efficient than pairwise tagging. Therefore, we developed a novel hybrid SNP selection method for the African American and Latino arrays utilizing rounds of greedy pairwise SNP selection, followed by removal from the target set of SNPs covered by imputation. The arrays provide excellent genome-wide coverage and are valuable additions for large-scale GWA studies. PMID:21903159

  9. Calculational assessment of critical experiments with mixed oxide fuel pin arrays moderated by organic solution

    SciTech Connect

    Smolen, G.R.

    1987-01-01

    Critical experiments have been conducted with organic-moderated mixed oxide (MOX) fuel pin assemblies at the Pacific Northwest Laboratory (PNL) Critical Mass Laboratory (CML). These experiments are part of a joint exchange program between the United States Department of Energy (USDOE) and the Power Reactor and Nuclear Fuel Development Corporation (PNC) of Japan in the area of criticality data development. The purpose of these experiments is to benchmark computer codes and cross-section libraries and to assess the reactivity difference between systems moderated by water and those moderated by an organic solution. Past studies have indicated that some organic mixtures may be better moderators than water. This topic is of particular importance to the criticality safety of fuel processing plants where fissile material is dissolved in organic solutions during the solvent extraction process. In the past, it has been assumed that the codes and libraries benchmarked with water-moderated experiments were adequate when performing design and licensing studies of organic-moderated systems. Calculations presented in this paper indicated that the SCALE code system and the 27-energy-group cross-section accurately compute k-effectives for organic moderated MOX fuel-pin assemblies. Furthermore, the reactivity of an organic solution with a 32-vol-% TBP/68-vol-% NPH mixture in a heterogeneous configuration is the same, for practical purposes, as water. 5 refs.

  10. The effect of the atmospheric condition on the extensive air shower analysis at the Telescope Array experiment

    SciTech Connect

    Kobayashi, Y.; Tsunesada, Y.; Tokuno, H.; Kakimoto, F.; Tomida, T.

    2011-09-22

    The accuracies in determination of air shower parameters such as longitudinal profiles or primary energies with the fluorescence detection technique are strongly dependent on atmospheric conditions of the molecular and aerosol components. Moreover, air fluorescence photon yield depends on the atmospheric density, and the transparency of the air for fluorescence photons depends on the atmospheric conditions from EAS to FDs. In this paper, we describe the atmospheric monitoring system in the Telescope Array (TA experiment), and the impact of the atmospheric conditions in air shower reconstructions. The systematic uncertainties of the determination of the primary cosmic ray energies and of the measurement of depth of maximum development (X{sub max}) of EASs due to atmospheric variance are evaluated by Monte Carlo simulation.

  11. Preparation and XRD analyses of Na-doped ZnO nanorod arrays based on experiment and theory

    NASA Astrophysics Data System (ADS)

    Yang, X. P.; Lu, J. G.; Zhang, H. H.; Chen, Y.; Kan, B. T.; Zhang, J.; Huang, J.; Lu, B.; Zhang, Y. Z.; Ye, Z. Z.

    2012-03-01

    ZnO nanorod arrays (NRAs) with different Na contents were prepared by thermal evaporation. Sodium pyrophosphate was adopted as the Na source. The Na contents in NRAs were determined by X-ray photoelectron spectra to be 0, 6.1, and 9.4 at.%. X-ray diffraction (XRD) analyses of Na-doped ZnO NRAs were performed in experiment and by first-principle calculation with the assumption of Na substitutions. A couple of typical changes were found in XRD patterns of Na-doped ZnO. The simulation results well agreed with the experimental data, which revealed that Na mainly located at the substitutional sites in Na-doped ZnO NRAs.

  12. Design and Development of High Voltage Direct Current (DC) Sources for the Solar Array Module Plasma Interaction Experiment

    NASA Technical Reports Server (NTRS)

    Bibyk, Irene K.; Wald, Lawrence W.

    1995-01-01

    Two programmable, high voltage DC power supplies were developed as part of the flight electronics for the Solar Array Module Plasma Interaction Experiment (SAMPIE). SAMPIE's primary objectives were to study and characterize the high voltage arcing and parasitic current losses of various solar cells and metal samples within the space plasma of low earth orbit (LEO). High voltage arcing can cause large discontinuous changes in spacecraft potential which lead to damage of the power system materials and significant Electromagnetic Interference (EMI). Parasitic currents cause a change in floating potential which lead to reduced power efficiency. These primary SAMPIE objectives were accomplished by applying artificial biases across test samples over a voltage range from -600 VDC to +300 VDC. This paper chronicles the design, final development, and test of the two programmable high voltage sources for SAMPIE. The technical challenges to the design for these power supplies included vacuum, space plasma effects, thermal protection, Shuttle vibrations and accelerations.

  13. Strategy for the deployment of a dense broadband temporary array in the Alps: lessons learnt from the CIFALPS experiment

    NASA Astrophysics Data System (ADS)

    Coralie, Aubert; Anne, Paul; Stefano, Solarino; Sandrine, Roussel; Simone, Salimbeni; Pierre, Zangelmi; Glenn, Cougoulat; Yinshuang, Ai; Weiwei, Xu; Yumei, He; Liang, Zhao

    2013-04-01

    The CIFALPS (China-Italy-France Alps seismic survey) experiment is a common project of IGGCAS (China), ISTerre (France) and INGV (Italy). It aims at getting new high-resolution passive seismic data on the crustal and upper mantle structure of the southwestern Alps. In this framework, we have installed a temporary broadband seismic array across the southwestern Alps from the Rhône valley (France) to the Po plain (Italy). The main sub-array of CIFALPS is a 350-km long roughly linear profile of 46 stations trending WSW-ENE from Bollène (France) to north of Alessandria (Italy). The average station spacing is 10 km in the outer parts of the belt, and it reduces to 5 km in the internal Alps. Nine additional temporary stations located ~40 km to the north and south of the main profile complement the permanent broadband networks to improve the 3-D constraints on the deep structures. Stations are equipped with Nanometrics Taurus data acquisition systems, and Trillium 120P/A, CMG3-ESP or CMG40T broadband sensors. The array was installed in the summer of 2012 and will be operated at least to April 2013. Because our schedule was tight, we had to achieve site selections in only 3-4 months in spite of strong constraints on site location related to short interstation spacing. Most sites are located in basements of buildings for security reasons and mains power supply. As most sensors are true broadband (90s or 120s), we put much effort on vault design to insure good thermal insulation and low noise at long periods. The vaults also had to be easily and rapidly built and they should be easily and totally removed at the end of the experiment. We used the PQLX software for quality control of our sites and vault design. The performances of our vaults are good for the vertical component with noise levels at 100s period in the range -185 dB (low noise model) to -165 dB. They are less good for horizontal components (noise level close to high noise model at periods > 20s) due to

  14. Genome-Wide Screening of Cytogenetic Abnormalities in Multiple Myeloma Patients Using Array-CGH Technique: A Czech Multicenter Experience

    PubMed Central

    Frohlich, Jan; Vallova, Vladimira; Greslikova, Henrieta; Kupska, Renata; Nemec, Pavel; Mikulasova, Aneta; Almasi, Martina; Pour, Ludek; Adam, Zdenek; Sandecka, Viera; Zahradová, Lenka; Hajek, Roman; Kuglik, Petr

    2014-01-01

    Characteristic recurrent copy number aberrations (CNAs) play a key role in multiple myeloma (MM) pathogenesis and have important prognostic significance for MM patients. Array-based comparative genomic hybridization (aCGH) provides a powerful tool for genome-wide classification of CNAs and thus should be implemented into MM routine diagnostics. We demonstrate the possibility of effective utilization of oligonucleotide-based aCGH in 91 MM patients. Chromosomal aberrations associated with effect on the prognosis of MM were initially evaluated by I-FISH and were found in 93.4% (85/91). Incidence of hyperdiploidy was 49.5% (45/91); del(13)(q14) was detected in 57.1% (52/91); gain(1)(q21) occurred in 58.2% (53/91); del(17)(p13) was observed in 15.4% (14/91); and t(4;14)(p16;q32) was found in 18.6% (16/86). Genome-wide screening using Agilent 44K aCGH microarrays revealed copy number alterations in 100% (91/91). Most common deletions were found at 13q (58.9%), 1p (39.6%), and 8p (31.1%), whereas gain of whole 1q was the most often duplicated region (50.6%). Furthermore, frequent homozygous deletions of genes playing important role in myeloma biology such as TRAF3, BIRC1/BIRC2, RB1, or CDKN2C were observed. Taken together, we demonstrated the utilization of aCGH technique in clinical diagnostics as powerful tool for identification of unbalanced genomic abnormalities with prognostic significance for MM patients. PMID:24987674

  15. Physical Science Informatics: Providing Open Science Access to Microheater Array Boiling Experiment Data

    NASA Technical Reports Server (NTRS)

    McQuillen, John; Green, Robert D.; Henrie, Ben; Miller, Teresa; Chiaramonte, Fran

    2014-01-01

    The Physical Science Informatics (PSI) system is the next step in this an effort to make NASA sponsored flight data available to the scientific and engineering community, along with the general public. The experimental data, from six overall disciplines, Combustion Science, Fluid Physics, Complex Fluids, Fundamental Physics, and Materials Science, will present some unique challenges. Besides data in textual or numerical format, large portions of both the raw and analyzed data for many of these experiments are digital images and video, requiring large data storage requirements. In addition, the accessible data will include experiment design and engineering data (including applicable drawings), any analytical or numerical models, publications, reports, and patents, and any commercial products developed as a result of the research. This objective of paper includes the following: Present the preliminary layout (Figure 2) of MABE data within the PSI database. Obtain feedback on the layout. Present the procedure to obtain access to this database.

  16. Mechanical Properties of Graphene Nanoplatelet Carbon Fiber Epoxy Hybrid Composites: Multiscale Modeling and Experiments

    NASA Technical Reports Server (NTRS)

    Hadden, Cameron M.; Klimek-McDonald, Danielle R.; Pineda, Evan J.; King, Julie A.; Reichanadter, Alex M.; Miskioglu, Ibrahim; Gowtham, S.; Odegard, Gregory M.

    2015-01-01

    Because of the relatively high specific mechanical properties of carbon fiber/epoxy composite materials, they are often used as structural components in aerospace applications. Graphene nanoplatelets (GNPs) can be added to the epoxy matrix to improve the overall mechanical properties of the composite. The resulting GNP/carbon fiber/epoxy hybrid composites have been studied using multiscale modeling to determine the influence of GNP volume fraction, epoxy crosslink density, and GNP dispersion on the mechanical performance. The hierarchical multiscale modeling approach developed herein includes Molecular Dynamics (MD) and micromechanical modeling, and it is validated with experimental testing of the same hybrid composite material system. The results indicate that the multiscale modeling approach is accurate and provides physical insight into the composite mechanical behavior. Also, the results quantify the substantial impact of GNP volume fraction and dispersion on the transverse mechanical properties of the hybrid composite, while the effect on the axial properties is shown to be insignificant.

  17. Mechanical Properties of Graphene Nanoplatelet/Carbon Fiber/Epoxy Hybrid Composites: Multiscale Modeling and Experiments

    NASA Technical Reports Server (NTRS)

    Hadden, C. M.; Klimek-McDonald, D. R.; Pineda, E. J.; King, J. A.; Reichanadter, A. M.; Miskioglu, I.; Gowtham, S.; Odegard, G. M.

    2015-01-01

    Because of the relatively high specific mechanical properties of carbon fiber/epoxy composite materials, they are often used as structural components in aerospace applications. Graphene nanoplatelets (GNPs) can be added to the epoxy matrix to improve the overall mechanical properties of the composite. The resulting GNP/carbon fiber/epoxy hybrid composites have been studied using multiscale modeling to determine the influence of GNP volume fraction, epoxy crosslink density, and GNP dispersion on the mechanical performance. The hierarchical multiscale modeling approach developed herein includes Molecular Dynamics (MD) and micromechanical modeling, and it is validated with experimental testing of the same hybrid composite material system. The results indicate that the multiscale modeling approach is accurate and provides physical insight into the composite mechanical behavior. Also, the results quantify the substantial impact of GNP volume fraction and dispersion on the transverse mechanical properties of the hybrid composite while the effect on the axial properties is shown to be insignificant.

  18. Mechanical Properties of Graphene Nanoplatelet/Carbon Fiber/Epoxy Hybrid Composites: Multiscale Modeling and Experiments

    NASA Technical Reports Server (NTRS)

    Hadden, C. M.; Klimek-McDonald, D. R.; Pineda, E. J.; King, J. A.; Reichanadter, A. M.; Miskioglu, I.; Gowtham, S.; Odegard, G. M.

    2015-01-01

    Because of the relatively high specific mechanical properties of carbon fiber/epoxy composite materials, they are often used as structural components in aerospace applications. Graphene nanoplatelets (GNPs) can be added to the epoxy matrix to improve the overall mechanical properties of the composite. The resulting GNP/carbon fiber/epoxy hybrid composites have been studied using multiscale modeling to determine the influence of GNP volume fraction, epoxy crosslink density, and GNP dispersion on the mechanical performance. The hierarchical multiscale modeling approach developed herein includes Molecular Dynamics (MD) and micromechanical modeling, and it is validated with experimental testing of the same hybrid composite material system. The results indicate that the multiscale modeling approach is accurate and provides physical insight into the composite mechanical behavior. Also, the results quantify the substantial impact of GNP volume fraction and dispersion on the transverse mechanical properties of the hybrid composite, while the effect on the axial properties is shown to be insignificant.

  19. High-resolution oligonucleotide array comparative genomic hybridization study and methylation status of the RPS14 gene in de novo myelodysplastic syndromes.

    PubMed

    Borze, Ioana; Juvonen, Eeva; Ninomiya, Shinsuke; Jee, Kowan Ja; Elonen, Erkki; Knuutila, Sakari

    2010-03-01

    In myelodysplastic syndromes (MDS), close to one half of patients do not have any visible karyotypic change. In order to study submicroscopic genomic alterations, we applied high-resolution array comparative genomic hybridization techniques (aCGH) in 37 patients with de novo MDS. Furthermore, we studied the methylation status of the RPS14 gene in 5q deletion (5q21.3q33.1) in 24 patients. In all, 21 of the 37 patients (57%) had copy number alterations. The most frequent copy number losses with minimal common overlapping areas were 5q21.3q33.1 (21%) and 7q22.1q33 (19%); the most frequent copy number gain was gain of the whole chromosome 8 (8%). Recurrent, but less frequent copy number losses were detected in two cases each: 11q14.1q22.1, 11q22.3q24.2, 12p12.2p13.31, 17p13.2, 18q12.1q12.2, 18q12.3q21.3, 18q21.2qter, and 20q11.23q12; the gains 8p23.2pter, 8p22p23.1, 8p12p21.1, and 8p11.21q21.2 were similarly found in two cases each. No homozygous losses or amplifications were observed. The RPS14 gene was not methylated in any of the patients. PMID:20193850

  20. A deep/wide 1-2 GHz snapshot survey of SDSS Stripe 82 using the Karl G. Jansky Very Large Array in a compact hybrid configuration

    NASA Astrophysics Data System (ADS)

    Heywood, I.; Jarvis, M. J.; Baker, A. J.; Bannister, K. W.; Carvalho, C. S.; Hardcastle, M.; Hilton, M.; Moodley, K.; Smirnov, O. M.; Smith, D. J. B.; White, S. V.; Wollack, E. J.

    2016-08-01

    We have used the Karl G. Jansky Very Large Array to image ˜100 deg2 of SDSS Stripe 82 at 1-2 GHz. The survey consists of 1026 snapshot observations of 2.5 min duration, using the hybrid CnB configuration. The survey has good sensitivity to diffuse, low surface brightness structures and extended radio emission, making it highly synergistic with existing 1.4 GHz radio observations of the region. The principal data products are continuum images, with 16 × 10 arcsec resolution, and a catalogue containing 11 782 point and Gaussian components resulting from fits to the thresholded Stokes-I brightness distribution, forming approximately 8948 unique radio sources. The typical effective 1σ noise level is 88 μJy beam-1. Spectral index estimates are included, as derived from the 1 GHz of instantaneous bandwidth. Astrometric and photometric accuracy are in excellent agreement with existing narrowband observations. A large-scale simulation is used to investigate clean bias, which we extend into the spectral domain. Clean bias remains an issue for snapshot surveys with the VLA, affecting our total intensity measurements at the ˜1σ level. Statistical spectral index measurements are in good agreement with existing measurements derived from matching separate surveys at two frequencies. At flux densities below ˜35σ the median in-band spectral index measurements begin to exhibit a bias towards flatness that is dependent on both flux density and the intrinsic spectral index. In-band spectral curvature measurements are likely to be unreliable for all but the very brightest components. Image products and catalogues are publicly available via an FTP server.

  1. A deep/wide 1-2 GHz snapshot survey of SDSS Stripe 82 using the Karl G. Jansky Very Large Array in a compact hybrid configuration

    NASA Astrophysics Data System (ADS)

    Heywood, I.; Jarvis, M. J.; Baker, A. J.; Bannister, K. W.; Carvalho, C. S.; Hardcastle, M.; Hilton, M.; Moodley, K.; Smirnov, O. M.; Smith, D. J. B.; White, S. V.; Wollack, E. J.

    2016-08-01

    We have used the Karl G. Jansky Very Large Array to image ~100 sq. deg. of SDSS Stripe 82 at 1-2 GHz. The survey consists of 1,026 snapshot observations of 2.5 minutes duration, using the hybrid CnB configuration. The survey has good sensitivity to diffuse, low surface brightness structures and extended radio emission, making it highly synergistic with existing 1.4 GHz radio observations of the region. The principal data products are continuum images, with 16 x 10 arcsecond resolution, and a catalogue containing 11,782 point and Gaussian components resulting from fits to the thresholded Stokes-I brightness distribution, forming approximately 8,948 unique radio sources. The typical effective 1{\\sigma} noise level is 88 {\\mu}Jy / beam. Spectral index estimates are included, as derived from the 1 GHz of instantaneous bandwidth. Astrometric and photometric accuracy are in excellent agreement with existing narrowband observations. A large-scale simulation is used to investigate clean bias, which we extend into the spectral domain. Clean bias remains an issue for snapshot surveys with the VLA, affecting our total intensity measurements at the ~1{\\sigma} level. Statistical spectral index measurements are in good agreement with existing measurements derived from matching separate surveys at two frequencies. At flux densities below ~35{\\sigma} the median in-band spectral index measurements begin to exhibit a bias towards flatness that is dependent on both flux density and the intrinsic spectral index. In-band spectral curvature measurements are likely to be unreliable for all but the very brightest components. Image products and catalogues are publicly available via an FTP server.

  2. Array-Based Comparative Genomic Hybridization Analysis Reveals Chromosomal Copy Number Aberrations Associated with Clinical Outcome in Canine Diffuse Large B-Cell Lymphoma

    PubMed Central

    Bresolin, Silvia; Marconato, Laura; Comazzi, Stefano; Te Kronnie, Geertruy; Aresu, Luca

    2014-01-01

    Canine Diffuse Large B-cell Lymphoma (cDLBCL) is an aggressive cancer with variable clinical response. Despite recent attempts by gene expression profiling to identify the dog as a potential animal model for human DLBCL, this tumor remains biologically heterogeneous with no prognostic biomarkers to predict prognosis. The aim of this work was to identify copy number aberrations (CNAs) by high-resolution array comparative genomic hybridization (aCGH) in 12 dogs with newly diagnosed DLBCL. In a subset of these dogs, the genetic profiles at the end of therapy and at relapse were also assessed. In primary DLBCLs, 90 different genomic imbalances were counted, consisting of 46 gains and 44 losses. Two gains in chr13 were significantly correlated with clinical stage. In addition, specific regions of gains and losses were significantly associated to duration of remission. In primary DLBCLs, individual variability was found, however 14 recurrent CNAs (>30%) were identified. Losses involving IGK, IGL and IGH were always found, and gains along the length of chr13 and chr31 were often observed (>41%). In these segments, MYC, LDHB, HSF1, KIT and PDGFRα are annotated. At the end of therapy, dogs in remission showed four new CNAs, whereas three new CNAs were observed in dogs at relapse compared with the previous profiles. One ex novo CNA, involving TCR, was present in dogs in remission after therapy, possibly induced by the autologous vaccine. Overall, aCGH identified small CNAs associated with outcome, which, along with future expression studies, may reveal target genes relevant to cDLBCL. PMID:25372838

  3. Hybrid Reynolds-Averaged/Large-Eddy Simulations of a Co-Axial Supersonic Free-Jet Experiment

    NASA Technical Reports Server (NTRS)

    Baurle, R. A.; Edwards, J. R.

    2009-01-01

    Reynolds-averaged and hybrid Reynolds-averaged/large-eddy simulations have been applied to a supersonic coaxial jet flow experiment. The experiment utilized either helium or argon as the inner jet nozzle fluid, and the outer jet nozzle fluid consisted of laboratory air. The inner and outer nozzles were designed and operated to produce nearly pressure-matched Mach 1.8 flow conditions at the jet exit. The purpose of the computational effort was to assess the state-of-the-art for each modeling approach, and to use the hybrid Reynolds-averaged/large-eddy simulations to gather insight into the deficiencies of the Reynolds-averaged closure models. The Reynolds-averaged simulations displayed a strong sensitivity to choice of turbulent Schmidt number. The baseline value chosen for this parameter resulted in an over-prediction of the mixing layer spreading rate for the helium case, but the opposite trend was noted when argon was used as the injectant. A larger turbulent Schmidt number greatly improved the comparison of the results with measurements for the helium simulations, but variations in the Schmidt number did not improve the argon comparisons. The hybrid simulation results showed the same trends as the baseline Reynolds-averaged predictions. The primary reason conjectured for the discrepancy between the hybrid simulation results and the measurements centered around issues related to the transition from a Reynolds-averaged state to one with resolved turbulent content. Improvements to the inflow conditions are suggested as a remedy to this dilemma. Comparisons between resolved second-order turbulence statistics and their modeled Reynolds-averaged counterparts were also performed.

  4. Testing for mating isolation between ecotypes: laboratory experiments with lake, stream and hybrid stickleback.

    PubMed

    Raeymaekers, J A M; Boisjoly, M; Delaire, L; Berner, D; Räsänen, K; Hendry, A P

    2010-12-01

    Mating isolation is a frequent contributor to ecological speciation - but how consistently does it evolve as a result of divergent selection? We tested for genetically based mating isolation between lake and stream threespine stickleback (Gasterosteus aculeatus L.) from the Misty watershed, Vancouver Island, British Columbia. We combined several design elements that are uncommon in the studies of stickleback mate choice: (i) we used second-generation laboratory-reared fish (to reduce environmental and maternal effects), (ii) we allowed for male-male competitive interactions (instead of the typical no-choice trials) and (iii) we included hybrids along with pure types. Males of different types (Lake, Inlet, hybrid) were paired in aquaria, allowed to build nests and then exposed sequentially to females of all three types. We found that Lake and Inlet males differed in behaviours thought to influence stickleback mate choice (inter- and intra-sexual aggression, display and nest activities), whereas hybrids were either intermediate or apparently 'inferior' in these behaviours. Despite these differences, Lake and Inlet fish did not mate assortatively and hybrid males did not have a mating disadvantage. Our study reinforces the noninevitability of mating isolation evolving in response to ecological differences and highlights the need to further investigate the factors promoting and constraining progress towards ecological speciation. PMID:20939859

  5. Research Experience with a Plug-In Hybrid Electric Vehicle: Preprint

    SciTech Connect

    Markel, T.; Pesaran, A.; Kelly, K.; Thornton, M.; Nortman, P.

    2007-12-01

    This technical document reports on the exploratory research conducted by NREL on PHEV technology using a Toyota Prius that has been converted to a plug-in hybrid electric vehicle. The data includes both controlled dynamometer and on-road test results, particularly for hilly driving. The results highlight the petroleum savings and benefits of PHEV technology.

  6. Hybrid Ground-Source Heat Pump Installations: Experiences, Improvements, and Tools

    SciTech Connect

    Scott Hackel; Amanda Pertzborn

    2011-06-30

    One innovation to ground-source heat pump (GSHP, or GHP) systems is the hybrid GSHP (HyGSHP) system, which can dramatically decrease the first cost of GSHP systems by using conventional technology (such as a cooling tower or a boiler) to meet a portion of the peak heating or cooling load. This work uses three case studies (two cooling-dominated, one heating-dominated) to demonstrate the performance of the hybrid approach. Three buildings were studied for a year; the measured data was used to validate models of each system. The models were used to analyze further improvements to the hybrid approach, and establish that this approach has positive impacts, both economically and environmentally. Lessons learned by those who design and operate the systems are also documented, including discussions of equipment sizing, pump operation, and cooling tower control. Finally, the measured data sets and models that were created during this work are described; these materials have been made freely available for further study of hybrid systems.

  7. HYBRID SNCR-SCR TECHNOLOGIES FOR NOX CONTROL: MODELING AND EXPERIMENT

    EPA Science Inventory

    The hybrid process of homogeneous gas-phase selective non-catalytic reduction (SNCR) followed by selective catalytic reduction (SCR) of nitric oxide (NO) was investigated through experimentation and modeling. Measurements, using NO-doped flue gas from a gas-fired 29 kW test combu...

  8. Self-Recovery Experiments in Extreme Environments Using a Field Programmable Transistor Array

    NASA Technical Reports Server (NTRS)

    Stoica, Adrian; Keymeulen, Didier; Arslan, Tughrul; Duong, Vu; Zebulum, Ricardo; Ferguson, Ian; Guo, Xin

    2004-01-01

    Temperature and radiation tolerant electronics, as well as long life survivability are key capabilities required for future NASA missions. Current approaches to electronics for extreme environments focus on component level robustness and hardening. However, current technology can only ensure very limited lifetime in extreme environments. This paper describes novel experiments that allow adaptive in-situ circuit redesign/reconfiguration during operation in extreme temperature and radiation environments. This technology would complement material/device advancements and increase the mission capability to survive harsh environments. The approach is demonstrated on a mixed-signal programmable chip (FPTA-2), which recovers functionality for temperatures until 28 C and with total radiation dose up to 250kRad.

  9. Phased-array components for the High-Temperature Superconducting Space Experiment (HTSSE). Final report

    SciTech Connect

    Not Available

    1991-06-07

    A new class of X-band phase shifters using the distributed Josephson inductance (DJI) effect were delivered to NRL for the HTS Space Experiment project. Phase shifts were observed above 77 K, and large phase shifts were observed at 65 K and below. This narrow-band device was developed as a first step to a broadband device. A total of 40 HTS SQUIDs were successfully integrated into a monolithic circuit. Measurement of the temperature dependance of the Q of a resonator in June 1990 and in February 1991 showed no significant change due to aging. A total of seven X-band phase shifters were fabricated, and five were delivered to Naval Research Laboratory. The HTS phase shifter consists of a low loss YBa2Cu3O7 microstrip resonator with 40 SQUID devices monolithically imbedded into the transmission line. This narrow-band device was developed as a first step to a broadband device.

  10. Phased array components for the High Temperature Superconducting Space Experiment (HTSSE)

    NASA Astrophysics Data System (ADS)

    1991-06-01

    A new class of X-band phase shifters using the distributed Josephson inductance (DJI) effect were delivered to NRL for the HTS Space Experiment project. Phase shifts were observed above 77 K, and large phase shifts were observed at 65 K and below. This narrow-band device was developed as a first step to a broadband device. A total of 40 HTS SQUIDs were successfully integrated into a monolithic circuit. Measurement of the temperature dependence of the Q of a resonator in June 1990 and in February 1991 showed no significant change due to aging. A total of seven X-band phase shifters were fabricated, and five were delivered to Naval Research Laboratory. The HTS phase shifter consists of a low loss YBa2Cu3O7 microstrip resonator with 40 SQUID devices monolithically imbedded into the transmission line. This narrow-band device was developed as a first step to a broadband device.

  11. LUNASKA experiments using the Australia Telescope Compact Array to search for ultrahigh energy neutrinos and develop technology for the lunar Cherenkov technique

    SciTech Connect

    James, C. W.; Protheroe, R. J.; Ekers, R. D.; Phillips, C. J.; Roberts, P.; Alvarez-Muniz, J.; Bray, J. D.; McFadden, R. A.

    2010-02-15

    We describe the design, performance, sensitivity and results of our recent experiments using the Australia Telescope Compact Array (ATCA) for lunar Cherenkov observations with a very wide (600 MHz) bandwidth and nanosecond timing, including a limit on an isotropic neutrino flux. We also make a first estimate of the effects of small-scale surface roughness on the effective experimental aperture, finding that contrary to expectations, such roughness will act to increase the detectability of near-surface events over the neutrino energy-range at which our experiment is most sensitive (though distortions to the time-domain pulse profile may make identification more difficult). The aim of our 'Lunar UHE Neutrino Astrophysics using the Square Kilometre Array' (LUNASKA) project is to develop the lunar Cherenkov technique of using terrestrial radio telescope arrays for ultrahigh energy (UHE) cosmic ray (CR) and neutrino detection, and, in particular, to prepare for using the Square Kilometre Array (SKA) and its path-finders such as the Australian SKA Pathfinder (ASKAP) and the Low Frequency Array (LOFAR) for lunar Cherenkov experiments.

  12. Emissivity measurements in support of experiments on natural convection between a vertical cylinder and a surrounding array

    SciTech Connect

    O`Brien, J.E.

    1991-12-01

    Experimental measurements of surface emissivities of three metallic samples have been obtained in support of an experiment aimed at determining natural convection and total heat transfer for a heated vertical cylinder surrounded by an array of cooled vertical tubes. In some cases, the heated stainless steel cylinder was shrouded by a perforated aluminum outer cylinder. The surrounding cooled tubes were also aluminum. In this experiment, heat transfer from the heated tube and the surrounding outer cylinder will occur by a combination of natural convection and radiation. At temperatures near the melting point of aluminum, the radiant contribution is particularly important, accounting for 50% or more of the total heat transfer. Consequently, accurate knowledge of surface emissivities of the heated rods, outer cylinders and surrounding structures is needed in order to predict the system thermal response during the transient. Direct measurements of surface emissivities have been obtained for one stainless steel and two aluminum samples. The measurements were obtained using an infrared pyrometer sensitive to the 8--14 {mu}m wavelength range. A procedure for estimating total hemispherical emissivities based on the measured spectral, normal results is also provided.

  13. Emissivity measurements in support of experiments on natural convection between a vertical cylinder and a surrounding array

    NASA Astrophysics Data System (ADS)

    Obrien, J. E.

    1991-12-01

    Experimental measurements of surface emissivities of three metallic samples have been obtained in support of an experiment aimed at determining natural convection and total heat transfer for a heated vertical cylinder surrounded by an array of cooled vertical tubes. In some cases, the heated stainless steel cylinder was shrouded by a perforated aluminum outer cylinder. The surrounding cooled tubes were also aluminum. In this experiment, heat transfer from the heated tube and the surrounding outer cylinder will occur by a combination of natural convection and radiation. At temperatures near the melting point of aluminum, the radiant contribution is particularly important, accounting for 50 percent or more of the total heat transfer. Consequently, accurate knowledge of surface emissivities of the heated rods, outer cylinders and surrounding structures is needed in order to predict the system thermal response during the transient. Direct measurements of surface emissivities have been obtained for one stainless steel and two aluminum samples. The measurements were obtained using an infrared pyrometer sensitive to the 8-14 micron wavelength range. A procedure for estimating total hemispherical emissivities based on the measured spectral, normal results is also provided.

  14. Survey of Field Programmable Gate Array Design Guides and Experience Relevant to Nuclear Power Plant Applications

    SciTech Connect

    Bobrek, Miljko; Bouldin, Don; Holcomb, David Eugene; Killough, Stephen M; Smith, Stephen Fulton; Ward, Christina D

    2007-09-01

    From a safety perspective, it is difficult to assess the correctness of FPGA devices without extensive documentation, tools, and review procedures. NUREG/CR-6463, "Review Guidelines on Software Languages for Use in Nuclear Power Plant Safety Systems," provides guidance to the Nuclear Regulatory Commission (NRC) on auditing of programs for safety systems written in ten high-level languages. A uniform framework for the formulation and discussion of language-specific programming guidelines was employed. Comparable guidelines based on a similar framework are needed for FPGA-based systems. The first task involves evaluation of regulatory experience gained by other countries and other agencies, and those captured in existing standards, to identify regulatory approaches that can be adopted by NRC. If existing regulations do not provide a sufficient regulatory basis for adopting relevant regulatory approaches that are uncovered, ORNL will identify the gaps. Information for this report was obtained through publicly available sources such as published papers and presentations. No proprietary information is represented.

  15. Energy spectrum and wavefunction of electrons in hybrid superconducting nanowires

    NASA Astrophysics Data System (ADS)

    Kruchinin, S. P.

    2016-03-01

    Recent experiments have fabricated structured arrays. We study hybrid nanowires, in which normal and superconducting regions are in close proximity, by using the Bogoliubov-de Gennes equations for superconductivity in a cylindrical nanowire. We succeed to obtain the quantum energy levels and wavefunctions of a superconducting nanowire. The obtained spectra of electrons remind Hofstadter’s butterfly.

  16. Synergistic effect of dual interfacial modifications with room-temperature-grown epitaxial ZnO and adsorbed indoline dye for ZnO nanorod array/P3HT hybrid solar cell.

    PubMed

    Chen, Dian-Wei; Wang, Ting-Chung; Liao, Wen-Pin; Wu, Jih-Jen

    2013-09-11

    ZnO nanorod (NR)/poly(3-hexylthiophene) (P3HT) hybrid solar cells with interfacial modifications are investigated in this work. The ZnO NR arrays are modified with room-temperature (RT)-grown epitaxial ZnO shells or/and D149 dye molecules prior to the P3HT infiltration. A synergistic effect of the dual modifications on the efficiency of the ZnO NR/P3HT solar cell is observed. The open-circuit voltage and fill factor are considerable improved through the RT-grown ZnO and D149 modifications in sequence on the ZnO NR array, which brings about a 2-fold enhancement of the efficiency of the ZnO NR/P3HT solar cell. We suggested that the more suitable surface of RT-grown ZnO for D149 adsorption, the chemical compatibility of D149 and P3HT, and the elevated conduction band edge of the RT-grown ZnO/D149-modified ZnO NR array construct the superior interfacial morphology and energetics in the RT-grown ZnO/D149-modified ZnO NR/P3HT hybrid solar cell, resulting in the synergistic effect on the cell efficiency. An efficiency of 1.16% is obtained in the RT-grown ZnO/D149-modified ZnO NR/P3HT solar cell. PMID:23937447

  17. Vibrations on the Roll - MANA, a Roll Along Array Experiment to map Local Site Effects Across a Fault System

    NASA Astrophysics Data System (ADS)

    Ohrnberger, M.; Scherbaum, F.; Hinzen, K. G.; Reamer, S. K.; Weber, B.

    2001-12-01

    The effects of surficial geology on seismic motion (site effects) are considered one of the major controlling factors to the damage distribution during earthquakes. Qualitative and quantitative estimates of local site amplifications provide important information for the identification of potential high risk areas. In this context, the analysis of ambient vibrations is an attractive tool for the mapping of site conditions. It is a low-cost alternative to expensive active seismic experiments or geophysical well-logging and especially well suited for the use within urban areas. Within the MANA experiment we conducted ambient vibration measurements at roughly 100 sites in the Lower Rhine Embayment (NW-Germany) to test various aspects of site effect determination, especially the feasibility of a roll along technique. A total of 13 three-component seismometers (5s corner period) have been used in a linear array configuration (station distance ~100 m). At all times during the roll-along experiment at least 8 stations (mostly 10) were operating simultaneously, meanwhilst the other stations were moved from the rear to the front of the line and re-installed. Thus, a total progress of almost 10 km could be obtained within two days. The line stretched across the NW-SE striking Erft fault system, one of the major faults in the eastern part of the Lower Rhine Embayment. The thickness of cenozoic soft-sediments overlying the basement of paleozoic age increases at the individual branches of the fault in abrupt steps of uncertain magnitude from around 200 m in the east to almost 1000 m in the west. The results of single station horizontal to vertical spectral ratios (HVSR) along the line are presented as well as the spatial evolution of local dispersion curves obtained from a slantstack analysis (SSA). The spatial variation of features along the line in both the HVSR and SSA are discussed in terms of sedimentary thickness and modifications of the wavefield properties of the ambient

  18. Mobile 3D quality of experience evaluation: a hybrid data collection and analysis approach

    NASA Astrophysics Data System (ADS)

    Utriainen, Timo; Häyrynen, Jyrki; Jumisko-Pyykkö, Satu; Boev, Atanas; Gotchev, Atanas; Hannuksela, Miska M.

    2011-02-01

    The paper presents a hybrid approach to study the user's experienced quality of 3D visual content on mobile autostereoscopic displays. It combines extensive subjective tests with collection and objective analysis of eye-tracked data. 3D cues which are significant for mobiles are simulated in the generated 3D test content. The methodology for conducting subjective quality evaluation includes hybrid data-collection of quantitative quality preferences, qualitative impressions, and binocular eye-tracking. We present early results of the subjective tests along with eye movement reaction times, areas of interest and heatmaps obtained from raw eye-tracked data after statistical analysis. The study contributes to the question what is important to be visualized on portable auto-stereoscopic displays and how to maintain and visually enhance the quality of 3D content for such displays.

  19. Hierarchical Modeling and Differential Expression Analysis for RNA-seq Experiments with Inbred and Hybrid Genotypes

    PubMed Central

    Lithio, Andrew; Nettleton, Dan

    2016-01-01

    The performance of inbred and hybrid genotypes is of interest in plant breeding and genetics. High-throughput sequencing of RNA (RNA-seq) has proven to be a useful tool in the study of the molecular genetic responses of inbreds and hybrids to environmental stresses. Commonly used experimental designs and sequencing methods lead to complex data structures that require careful attention in data analysis. We demonstrate an analysis of RNA-seq data from a split-plot design involving drought stress applied to two inbred genotypes and two hybrids formed by crosses between the inbreds. Our generalized linear modeling strategy incorporates random effects for whole-plot experimental units and uses negative binomial distributions to allow for overdispersion in count responses for split-plot experimental units. Variations in gene length and base content, as well as differences in sequencing intensity across experimental units, are also accounted for. Hierarchical modeling with thoughtful parameterization and prior specification allows for borrowing of information across genes to improve estimation of dispersion parameters, genotype effects, treatment effects, and interaction effects of primary interest. PMID:27110090

  20. A study on carbon nanotube titanium dioxide hybrids: experiment and calculation

    NASA Astrophysics Data System (ADS)

    Thuy Nguyen, Minh; Khang Nguyen, Cao; Phuong Vu, Thi Mai; Van Duong, Quoc; Pham, Tien Lam; Nguyen, Tien Cuong

    2014-12-01

    Carbon nanotubes (CNTs) were coated TiO2 nanoparticles via sol-gel process using titanium tetra-isoproxide Ti[OCH(CH3)2]4 (TTIP). The structure of TiO2/CNT hybrid samples was determined by x-ray diffractometer D5005 (Siemen) with CuKα radiation. Their morphology and sizes were investigated with FE-SEM and HR-TEM, which shows that nanoparticles were coated on CNTs. The UV-vis absorption results indicate interaction between TiO2 and CNTs, the composite material can absorb at higher wavelength and the absorption even covers the whole range of visible region. By investigating different addition ratios of CNT on the photocatalytic activity of TiO2/CNTs, we find that the higher ratio in TiO2/CNT will decrease the photocatalytic activity. We have calculated the electronic structure of the anatase TiO2 and single-wall carbon nanotube (SWCNT) by first-principles stimulation. We investigate the property in hybrid structure: molecular and small clusters of TiO2 adsorbed on SWCNT support using density functional calculation. The energy and charge distribution calculations show that SWCNT can make TiO2 clusters become more stable in the hybrid system.

  1. High-resolution seismic array imaging using teleseismic scattered waves

    NASA Astrophysics Data System (ADS)

    Tong, P.; Liu, Q.; Chen, C.; Basini, P.; Komatitsch, D.

    2013-12-01

    The advent of dense seismic networks, new modeling and imaging techniques, and increased HPC capacity makes it feasible to resolve subsurface interfaces and structural anomalies beneath seismic arrays at unprecedented details based on teleseismic scattered records. To accurately and efficiently simulate the full propagation of teleseismic waves beneath receiver arrays at the frequencies relevant to scattering imaging, we develop a hybrid method that interfaces a frequency-wavenumber (FK) calculation, which provides semi-analytical solutions to one-dimensional layered background models, with a 2D/3D spectral-element (SEM) numerical solver to calculate synthetic responses of local media to plane-wave incidence. This hybrid method accurately deals with local heterogeneities and discontinuity undulations, and represents an efficient tool for the forward modelling of teleseismic coda (including converted and scattered) waves. Meanwhile, adjoint tomography is a powerful tool for high-resolution imaging in heterogeneous media, which can resolve large velocity contrasts through the use of 2D/3D initial models and full numerical simulations for forward wavefields and sensitivity kernels. In the framework of adjont tomography and hybrid method, we compute sensitivity kernels for teleseismic coda waves, which provide the basis for mapping variations in subsurface discontinuities, density and velocity structures through nonlinear conjugate-gradient methods. Various 2D synthetic imaging examples show that inversion of teleseismic coda phases based on the 2D SEM-FK hybrid method and adjoint techniques is a promising tool for structural imaging beneath dense seismic arrays. 3D synthetic experiments will be performed to test the feasibility of seismic array imaging using adjoint method and 3D SEM-FK hybrid method. We will also apply this hybrid imaging techniques to realistic seismic data, such as the recorded SsPmP phases in central Tibet, to explore high-resolution subsurface

  2. High performance visible and near-infrared charge-coupled-device array for spectroscopy applications. [in Shuttle Image Spectrometer Experiment

    NASA Technical Reports Server (NTRS)

    Wang, Weng-Lyang; Hudson, Leland R.; Tseng, Hsin-Fu

    1987-01-01

    This paper describes the design and performance of a scientific CCD array for use in NASA's Shuttle Image Spectrometer Experiment. The device is a four-phase, buried-channel CCD structure that operates in the frame-transfer mode. The sensor consists of 64 x 404 pixels, has a 100 percent fill factor, and operates in the visible and near-infrared spectral regions. In operation, the 404 horizontal elements provide spatial information, while the 64 vertical elements give spectral information covering the wavelength range of 400 to 1000 nm in 10 nm increments. The high full-well capacity of each pixel and low noise floor yield a dynamic range of more than 95 dB. In addition, the device has been designed to have good linearity characteristics. The unique dual-output structure allows a horizontal row to be read out to the right or to the left, or it can be split from the middle to both right and left output circuits simultaneously for high speed applications. The power dissipation of the device is about 60 mW.

  3. Matrix-addressable, active electrode arrays for neural stimulation using organic semiconductors—cytotoxicity and pilot experiments in vivo

    NASA Astrophysics Data System (ADS)

    Feili, Dara; Schuettler, Martin; Stieglitz, Thomas

    2008-03-01

    Organic field effect transistors can be integrated into micromachined polyimide-based neural stimulation electrode arrays in order to build active switching matrices. With this approach, a matrix of N × M electrode contacts requires only N + M interconnects to a stimulator when active switching elements are used instead of N × M interconnects. In this paper, we demonstrated that pentacene-based organic field effect transistors (OFETs) can be used to drive stimulation currents through neural electrodes in a physiological-like environment. In order to prove the general applicability as an implant material, the cytotoxicity of pentacene was evaluated with respect to potential effects on cell viability. The results of these tests indicate that extracts from pentacene inhibit neither proliferation nor metabolism of the tested mouse fibroblasts. However, some effect on cell spreading was observed when cells were in direct contact to pentacene for 48 h. In pilot experiments it was demonstrated for the very first time that pentacene transistors can be used as switching elements, acting as voltage-controlled current sources, capable of driving currents suitable for electrical stimulation of a peripheral nerve via a tripolar cuff electrode.

  4. A Northern Sky Survey for Point-like Sources of EeV Neutral Particles with the Telescope Array Experiment

    NASA Astrophysics Data System (ADS)

    Abbasi, R. U.; Abe, M.; Abu-Zayyad, T.; Allen, M.; Anderson, R.; Azuma, R.; Barcikowski, E.; Belz, J. W.; Bergman, D. R.; Blake, S. A.; Cady, R.; Chae, M. J.; Cheon, B. G.; Chiba, J.; Chikawa, M.; Cho, W. R.; Fujii, T.; Fukushima, M.; Goto, T.; Hanlon, W.; Hayashi, Y.; Hayashida, N.; Hibino, K.; Honda, K.; Ikeda, D.; Inoue, N.; Ishii, T.; Ishimori, R.; Ito, H.; Ivanov, D.; Jui, C. C. H.; Kadota, K.; Kakimoto, F.; Kalashev, O.; Kasahara, K.; Kawai, H.; Kawakami, S.; Kawana, S.; Kawata, K.; Kido, E.; Kim, H. B.; Kim, J. H.; Kim, J. H.; Kitamura, S.; Kitamura, Y.; Kuzmin, V.; Kwon, Y. J.; Lan, J.; Lim, S. I.; Lundquist, J. P.; Machida, K.; Martens, K.; Matsuda, T.; Matsuyama, T.; Matthews, J. N.; Minamino, M.; Mukai, K.; Myers, I.; Nagasawa, K.; Nagataki, S.; Nakamura, T.; Nonaka, T.; Nozato, A.; Ogio, S.; Ogura, J.; Ohnishi, M.; Ohoka, H.; Oki, K.; Okuda, T.; Ono, M.; Oshima, A.; Ozawa, S.; Park, I. H.; Pshirkov, M. S.; Rodriguez, D. C.; Rubtsov, G.; Ryu, D.; Sagawa, H.; Sakurai, N.; Sampson, A. L.; Scott, L. M.; Shah, P. D.; Shibata, F.; Shibata, T.; Shimodaira, H.; Shin, B. K.; Smith, J. D.; Sokolsky, P.; Springer, R. W.; Stokes, B. T.; Stratton, S. R.; Stroman, T. A.; Suzawa, T.; Takamura, M.; Takeda, M.; Takeishi, R.; Taketa, A.; Takita, M.; Tameda, Y.; Tanaka, H.; Tanaka, K.; Tanaka, M.; Thomas, S. B.; Thomson, G. B.; Tinyakov, P.; Tkachev, I.; Tokuno, H.; Tomida, T.; Troitsky, S.; Tsunesada, Y.; Tsutsumi, K.; Uchihori, Y.; Udo, S.; Urban, F.; Vasiloff, G.; Wong, T.; Yamane, R.; Yamaoka, H.; Yamazaki, K.; Yang, J.; Yashiro, K.; Yoneda, Y.; Yoshida, S.; Yoshii, H.; Zollinger, R.; Zundel, Z.

    2015-05-01

    We report on the search for steady point-like sources of neutral particles around 1018 eV between 2008 and 2013 May with the scintillator SD of the Telescope Array experiment. We found overall no significant point-like excess above 0.5 EeV in the northern sky. Subsequently, we also searched for coincidence with the Fermi bright Galactic sources. No significant coincidence was found within the statistical uncertainty. Hence, we set an upper limit on the neutron flux that corresponds to an averaged flux of 0.07 km-2 yr-1 for E\\gt 1 EeV in the northern sky at the 95% confidence level. This is the most stringent flux upper limit in a northern sky survey assuming point-like sources. The upper limit at the 95% confidence level on the neutron flux from Cygnus X-3 is also set to 0.2 km-2 yr-1 for E\\gt 0.5 EeV. This is an order of magnitude lower than previous flux measurements.

  5. AIDA: A 16-channel amplifier ASIC to read out the advanced implantation detector array for experiments in nuclear decay spectroscopy

    SciTech Connect

    Braga, D.; Coleman-Smith, P. J.; Davinson, T.; Lazarus, I. H.; Page, R. D.; Thomas, S.

    2011-07-01

    We have designed a read-out ASIC for nuclear decay spectroscopy as part of the AIDA project - the Advanced Implantation Detector Array. AIDA will be installed in experiments at the Facility for Antiproton and Ion Research in GSI, Darmstadt. The AIDA ASIC will measure the signals when unstable nuclei are implanted into the detector, followed by the much smaller signals when the nuclei subsequently decay. Implant energies can be as high as 20 GeV; decay products need to be measured down to 25 keV within just a few microseconds of the initial implants. The ASIC uses two amplifiers per detector channel, one covering the 20 GeV dynamic range, the other selectable over a 20 MeV or 1 GeV range. The amplifiers are linked together by bypass transistors which are normally switched off. The arrival of a large signal causes saturation of the low-energy amplifier and a fluctuation of the input voltage, which activates the link to the high-energy amplifier. The bypass transistors switch on and the input charge is integrated by the high-energy amplifier. The signal is shaped and stored by a peak-hold, then read out on a multiplexed output. Control logic resets the amplifiers and bypass circuit, allowing the low-energy amplifier to measure the subsequent decay signal. We present simulations and test results, demonstrating the AIDA ASIC operation over a wide range of input signals. (authors)

  6. Constraining Polarized Foregrounds for EoR Experiments I: 2D Power Spectra from the PAPER-32 Imaging Array

    NASA Astrophysics Data System (ADS)

    Kohn, S. A.; Aguirre, J. E.; Nunhokee, C. D.; Bernardi, G.; Pober, J. C.; Ali, Z. S.; Bradley, R. F.; Carilli, C. L.; DeBoer, D. R.; Gugliucci, N. E.; Jacobs, D. C.; Klima, P.; MacMahon, D. H. E.; Manley, J. R.; Moore, D. F.; Parsons, A. R.; Stefan, I. I.; Walbrugh, W. P.

    2016-06-01

    Current generation low-frequency interferometers constructed with the objective of detecting the high-redshift 21 cm background aim to generate power spectra of the brightness temperature contrast of neutral hydrogen in primordial intergalactic medium. Two-dimensional (2D) power spectra (power in Fourier modes parallel and perpendicular to the line of sight) that formed from interferometric visibilities have been shown to delineate a boundary between spectrally smooth foregrounds (known as the wedge) and spectrally structured 21 cm background emission (the EoR window). However, polarized foregrounds are known to possess spectral structure due to Faraday rotation, which can leak into the EoR window. In this work we create and analyze 2D power spectra from the PAPER-32 imaging array in Stokes I, Q, U, and V. These allow us to observe and diagnose systematic effects in our calibration at high signal-to-noise within the Fourier space most relevant to EoR experiments. We observe well-defined windows in the Stokes visibilities, with Stokes Q, U, and V power spectra sharing a similar wedge shape to that seen in Stokes I. With modest polarization calibration, we see no evidence that polarization calibration errors move power outside the wedge in any Stokes visibility to the noise levels attained. Deeper integrations will be required to confirm that this behavior persists to the depth required for EoR detection.

  7. Experiments with a Gas-Puff-On-Wire-Array Load on the GIT-12 Generator for Al K-shell Radiation Production at Microsecond Implosion Times

    NASA Astrophysics Data System (ADS)

    Shishlov, Alexander V.; Baksht, Rina B.; Chaikovsky, Stanislav A.; Fedunin, Anatoly V.; Fursov, Fedor I.; Kovalchuk, Boris M.; Kokshenev, Vladimir A.; Kurmaev, Nikolai E.; Labetsky, Aleksey Yu.; Oreshkin, Vladimir I.; Rousskikh, Alexander G.; Lassalle, Francis; Bayol, Frederic

    2006-01-01

    Results of the experiments carried out on the GIT-12 generator at the current level of 3.5 MA and the Z-pinch implosion times from 700 ns to 1.1 μs are presented. A multi-shell (triple-shell) load configuration with the outer gas puffs (neon) and the inner wire array (aluminum) was used in the experiments. In the course of the research, implosion dynamics of the triple-shell z-pinch was studied, and the radiation yield in the spectral range of neon and aluminum K-lines have been measured. Optimization of the inner wire array parameters aimed at obtaining the maximum aluminum K-shell radiation yield has been carried out. As a result of optimization of the gas-puff-on-wire-array Z-pinch load, the aluminum K-shell radiation yield (hv> 1.55 keV) up to 4 kJ/cm in the radiation pulse with FWHM less than 30 ns has been obtained. Comparison of the experimental results with the results of preliminary 1D RMHD simulations allows a conclusion that at least 2/3 of the generator current is switched from a gas puff to an aluminum wire array. The radiation yield in the spectral range of neon K-lines (0.92-1.55 keV) increases considerably in the shots with the inner wire array in comparison with the shots carried out with the outer gas puffs only. The radiation yield in the spectral range above 1 keV registered in the experiments reached 10 kJ/cm. The presence of a high portion of the neon plasma inside an inner wire array can limit the radiation yield in the spectral range above 1.55 keV.

  8. Group and phase velocities from deterministic and ambient sources measured during the AlpArray-EASI experiment

    NASA Astrophysics Data System (ADS)

    Kolínský, Petr; Zigone, Dimitri; Fuchs, Florian; Bianchi, Irene; Qorbani, Ehsan; Apoloner, Maria-Theresia; Bokelmann, Götz; AlpArray-EASI Working Group

    2016-04-01

    The Eastern Alpine Seismic Investigation (EASI) was a complementary experiment to the AlpArray project. EASI was composed of 55 broadband seismic stations deployed in a winding swath of 540 km length along longitude 13.350 E from the Czech-German border to the Adriatic Sea. Average north-south inter-station distance was 10 km, the distance of each station to either side of the central line was 6 km. Such a dense linear network allows for surface wave dispersion measurements by both deterministic and ambient noise sources along the same paths. During the experiment (July 2014 - August 2015), three earthquakes ML = 2.6, 2.9 and 4.2 occurred in Austria and Northern Italy only several kilometers off the swath. We measure Rayleigh and Love wave group velocities between the source and a single station for the recorded earthquakes, as well as phase velocities between selected pairs of stations using the standard two-station method. We also calculate cross-correlations of ambient noise between selected pairs of stations and we determine the corresponding group velocity dispersion curves. We propose a comparison of phase velocities between two stations measured from earthquakes with group velocities obtained from cross-correlations for the same station pairs. We also compare group velocities measured at single station using earthquakes, which occurred along the swath, with group velocities measured from cross-correlations. That way we analyze velocities of both deterministic and ambient noise reconstructed surface waves propagating along the same path. We invert the resulting dispersion curves for 1D shear wave velocity profiles with depth and we compile a quasi-2D velocity model along the EASI swath.

  9. Image fiber optic space-CDMA parallel transmission experiment using 8 x 8 VCSEL/PD arrays.

    PubMed

    Nakamura, Moriya; Kitayama, Ken-ichi; Igasaki, Yasunori; Shamoto, Naoki; Kaneda, Keiji

    2002-11-10

    We experimentally demonstrate space-code-division multiple access (space-CDMA) based twodimensional (2-D) parallel optical interconnections by using image fibers and 8 x 8 vertical-cavity surface-emitting laser (VCSEL)/photo diode (PD) arrays. Two spatially encoded four-bit (2 x 2) parallel optical signals were emitted fiom 2-D VCSEL arrays and transmitted through image fibers. The encoded signals were multiplexed by an image-fiber coupler and detected by a 2-D PD array on the receiver side. The receiver recovered the intended parallel signal by decoding the signal. The transmission speed was 64 Mbps/ch (total throughput: 512 Mbps). Bit-error-rate (BER) measurement with a laterally misaligned PD array showed the array had a misalignment tolerance of 25 microm for a BER performance of 10(-9). PMID:12440546

  10. The new hybrid thermal neutron facility at TAPIRO reactor for BNCT radiobiological experiments.

    PubMed

    Esposito, J; Rosi, G; Agosteo, S

    2007-01-01

    A new thermal neutron irradiation facility, devoted to carry out both dosimetric and radiobiological studies on boron carriers, which are being developed in the framework of INFN BNCT project, has been installed at the ENEA Casaccia TAPIRO research fast reactor. The thermal column, based on an original, hybrid, neutron spectrum shifter configuration, has been recently become operative. In spite of its low power (5 kW), the new facility is able to provide a high thermal neutron flux level, uniformly distributed inside the irradiation cavity, with a quite low gamma background. The main features and preliminary benchmark measurements of the Beam-shaping assembly are here presented and discussed. PMID:17504745

  11. Initial experience with a novel hybrid vascular graft for peripheral artery disease.

    PubMed

    Willaert, W; Claes, K; Flamme, A; Jacobs, B

    2014-03-01

    This report describes the successful use of a new hybrid vascular graft as a conduit for above knee femoropopliteal bypass surgery. The graft consists of a proximal (heparin coated) expanded polytetrafluoroethylene section but ends distally as a nitinol reinforced selfexpandable stent that is covered and constrained, allowing a sutureless distal anastamosis. With this graft the creation of above knee bypasses in situations where lesions extend to the popliteal artery behind the knee, or in cases where the above knee popliteal artery is severely calcified is still possible. This avoids the necessity of an infragenicular bypass with potentially inferior longterm patency rates, especially when no autologous venous bypass material is available. PMID:24594800

  12. Evaluation of a Hybrid Dynamic Stabilization and Fusion System in the Lumbar Spine: A 10 Year Experience

    PubMed Central

    Kashkoush, Ahmed; Agarwal, Nitin; Paschel, Erin; Goldschmidt, Ezequiel

    2016-01-01

    Introduction: The development of adjacent-segment disease is a recognized consequence of lumbar fusion surgery. Posterior dynamic stabilization, or motion preservation, techniques have been developed which theoretically decrease stress on adjacent segments following fusion. This study presents the experience of using a hybrid dynamic stabilization and fusion construct for degenerative lumbar spine pathology in place of rigid arthrodesis. Methods: A clinical cohort investigation was conducted of 66 consecutive patients (31 female, 35 male; mean age: 53 years, range: 25 – 76 years) who underwent posterior lumbar instrumentation with the Dynesys Transition Optima (DTO) implant (Zimmer-Biomet Spine, Warsaw, IN) hybrid dynamic stabilization and fusion system over a 10-year period. The median length of follow-up was five years. DTO consists of pedicle screw fixation coupled to a rigid rod as well as a flexible longitudinal connecting system. All patients had symptoms of back pain and neurogenic claudication refractory to non-surgical treatment. Patients underwent lumbar arthrodesis surgery in which the hybrid system was used for stabilization instead of arthrodesis of the stenotic adjacent level. Results: Indications for DTO instrumentation were primary degenerative disc disease (n = 52) and failed back surgery syndrome (n = 14). The most common dynamically stabilized and fused segments were L3-L4 (n = 37) and L5-S1 (n = 33), respectively. Thirty-eight patients (56%) underwent decompression at the dynamically stabilized level, and 57 patients (86%) had an interbody device placed at the level of arthrodesis. Complications during the follow-up period included a single case of screw breakage and a single case of pseudoarthrosis. Ten patients (15%) subsequently underwent conversion of the dynamic stabilization portion of their DTO instrumentation to rigid spinal arthrodesis. Conclusion: The DTO system represents a novel hybrid dynamic stabilization and fusion construct

  13. Excited state and charge dynamics of hybrid organic/inorganic heterojunctions. II. Experiment

    NASA Astrophysics Data System (ADS)

    Panda, Anurag; Renshaw, C. Kyle; Oskooi, Ardavan; Lee, Kyusang; Forrest, Stephen R.

    2014-07-01

    In our companion paper (Paper I) [C. K. Renshaw and S. R. Forrest, Phys. Rev. B 90, 045302 (2014), 10.1103/PhysRevB.90.045302], we developed a model for charge transport and photogeneration at hybrid organic/inorganic semiconductor heterojunctions (OI-HJs). Here we apply the model to two planar bilayer hybrid photovoltaic devices: the first using the wide-band gap n-TiO2 in combination with the hole transporting tetraphenyl-dibenzoperiflanthene (DBP), and the second based on the moderate-band gap n-InP and the hole transporting pentacene (PEN). We measure the external quantum efficiency (EQE) and current density vs voltage (J-V) characteristics of both devices as functions of temperature. The EQE spectra for both TiO2/DBP and InP/PEN provide convincing evidence that Frenkel states generated in the organic form hybrid charge transfer excitons (HCTEs) at the OI-HJ that are subsequently dissociated into free charges, and then collected at the opposing electrodes. The dissociation efficiency is found to be strongly influenced by the presence of surface states, particularly in the InP/PEN device. We further develop the J-V model from Paper I to include an analytical expression for space-charge effects in the organic at high currents. Model fits to the J-V data suggest that the temperature-dependent hole mobilities in both DBP and PEN result in increasing space-charge effects at low temperatures. Furthermore, we find that the J-V characteristics of the TiO2/DBP device both in the dark and under illumination are governed by interface recombination. In contrast, the dark current in the InP/PEN device is governed by injection over the OI-HJ barrier, whereas the photocurrent is dominated by interface recombination. This work elucidates the role of the HCTE state in photogeneration, and the applicability of our model to a range of important optoelectronic devices.

  14. Hybrid Wing Body Aircraft System Noise Assessment with Propulsion Airframe Aeroacoustic Experiments

    NASA Technical Reports Server (NTRS)

    Thomas, Russell H.; Burley, Casey L.; Olson, Erik D.

    2010-01-01

    A system noise assessment of a hybrid wing body configuration was performed using NASA s best available aircraft models, engine model, and system noise assessment method. A propulsion airframe aeroacoustic effects experimental database for key noise sources and interaction effects was used to provide data directly in the noise assessment where prediction methods are inadequate. NASA engine and aircraft system models were created to define the hybrid wing body aircraft concept as a twin engine aircraft with a 7500 nautical mile mission. The engines were modeled as existing technology high bypass ratio turbofans. The baseline hybrid wing body aircraft was assessed at 22 dB cumulative below the FAA Stage 4 certification level. To determine the potential for noise reduction with relatively near term technologies, seven other configurations were assessed beginning with moving the engines two fan nozzle diameters upstream of the trailing edge and then adding technologies for reduction of the highest noise sources. Aft radiated noise was expected to be the most challenging to reduce and, therefore, the experimental database focused on jet nozzle and pylon configurations that could reduce jet noise through a combination of source reduction and shielding effectiveness. The best configuration for reduction of jet noise used state-of-the-art technology chevrons with a pylon above the engine in the crown position. This configuration resulted in jet source noise reduction, favorable azimuthal directivity, and noise source relocation upstream where it is more effectively shielded by the limited airframe surface, and additional fan noise attenuation from acoustic liner on the crown pylon internal surfaces. Vertical and elevon surfaces were also assessed to add shielding area. The elevon deflection above the trailing edge showed some small additional noise reduction whereas vertical surfaces resulted in a slight noise increase. With the effects of the configurations from the

  15. Competitive hybridization models

    NASA Astrophysics Data System (ADS)

    Cherepinsky, Vera; Hashmi, Ghazala; Mishra, Bud

    2010-11-01

    Microarray technology, in its simplest form, allows one to gather abundance data for target DNA molecules, associated with genomes or gene-expressions, and relies on hybridizing the target to many short probe oligonucleotides arrayed on a surface. While for such multiplexed reactions conditions are optimized to make the most of each individual probe-target interaction, subsequent analysis of these experiments is based on the implicit assumption that a given experiment yields the same result regardless of whether it was conducted in isolation or in parallel with many others. It has been discussed in the literature that this assumption is frequently false, and its validity depends on the types of probes and their interactions with each other. We present a detailed physical model of hybridization as a means of understanding probe interactions in a multiplexed reaction. Ultimately, the model can be derived from a system of ordinary differential equations (ODE’s) describing kinetic mass action with conservation-of-mass equations completing the system. We examine pairwise probe interactions in detail and present a model of “competition” between the probes for the target—especially, when the target is effectively in short supply. These effects are shown to be predictable from the affinity constants for each of the four probe sequences involved, namely, the match and mismatch sequences for both probes. These affinity constants are calculated from the thermodynamic parameters such as the free energy of hybridization, which are in turn computed according to the nearest neighbor (NN) model for each probe and target sequence. Simulations based on the competitive hybridization model explain the observed variability in the signal of a given probe when measured in parallel with different groupings of other probes or individually. The results of the simulations can be used for experiment design and pooling strategies, based on which probes have been shown to have a strong

  16. Coupling characteristics of the ITER relevant lower hybrid antenna in Tore Supra: experiments and modelling

    SciTech Connect

    Preynas, M.; Ekedahl, A.; Fedorczak, N.; Goniche, M.; Guilhem, D.; Gunn, J. P.; Hillairet, J.; Litaudon, X.

    2011-12-23

    A new concept of lower hybrid antenna for current drive has been proposed for ITER [Bibet et al, Nuclear Fusion 1995]: the Passive Active Multijunction (PAM) antenna that relies on a periodic combination of active and passive waveguides. An actively cooled PAM antenna at 3.7 GHz has been recently installed on the tokamak Tore Supra. The paper summarizes the comprehensive experimental characterization of the linear coupling properties of the PAM antenna to the Tore Supra plasmas. These experimental results are systematically compared with the linear wave coupling theory via the linear ALOHA code. Good agreement between experimental results and ALOHA have been obtained. The detailed validation of the coupling modelling is an important step toward the validation of the PAM concept in view of further optimizing the electromagnetic properties of the future ITER antenna.

  17. High Reynolds Number Hybrid Laminar Flow Control (HLFC) Flight Experiment. Report 2; Aerodynamic Design

    NASA Technical Reports Server (NTRS)

    1999-01-01

    This document describes the aerodynamic design of an experimental hybrid laminar flow control (HLFC) wing panel intended for use on a Boeing 757 airplane to provide a facility for flight research on high Reynolds number HLFC and to demonstrate practical HLFC operation on a full-scale commercial transport airplane. The design consists of revised wing leading edge contour designed to produce a pressure distribution favorable to laminar flow, definition of suction flow requirements to laminarize the boundary layer, provisions at the inboard end of the test panel to prevent attachment-line boundary layer transition, and a Krueger leading edge flap that serves both as a high lift device and as a shield to prevent insect accretion on the leading edge when the airplane is taking off or landing.

  18. Coupling characteristics of the ITER relevant lower hybrid antenna in Tore Supra: experiments and modelling

    NASA Astrophysics Data System (ADS)

    Preynas, M.; Ekedahl, A.; Fedorczak, N.; Goniche, M.; Guilhem, D.; Gunn, J. P.; Hillairet, J.; Litaudon, X.

    2011-12-01

    A new concept of lower hybrid antenna for current drive has been proposed for ITER [Bibet et al, Nuclear Fusion 1995]: the Passive Active Multijunction (PAM) antenna that relies on a periodic combination of active and passive waveguides. An actively cooled PAM antenna at 3.7 GHz has been recently installed on the tokamak Tore Supra. The paper summarizes the comprehensive experimental characterization of the linear coupling properties of the PAM antenna to the Tore Supra plasmas. These experimental results are systematically compared with the linear wave coupling theory via the linear ALOHA code. Good agreement between experimental results and ALOHA have been obtained. The detailed validation of the coupling modelling is an important step toward the validation of the PAM concept in view of further optimizing the electromagnetic properties of the future ITER antenna.

  19. First Results From the Alcator C-Mod Lower Hybrid Experiment

    NASA Astrophysics Data System (ADS)

    Parker, Ronald; Bernabei, Stefano; Grimes, Montgomery; Hosea, Joel; Johnson, David; Wilson, Randy

    2005-10-01

    A lower hybrid system operating at 4.6 GHz and capable of 3 MW source power has been installed on Alcator C-Mod. The grill facing the plasma consists of 4 rows of 24 waveguides. Electronic control of the amplitude and phase of the 12 klystrons supplying the RF power enables the launcher's n|| spectrum to be dynamically controlled over a wide range with a time response of 1 ms. Since the deposition of current depends on n|| as well as the temperature profile, the spatial distribution of the driven current can be varied with the same time response. Detection of fast electron Bremsstrahlung is the primary means of monitoring the driven current profile. Initial measurements at the 100 kW power level show that reflection coefficients as low as 7% are obtained at optimal phasing and density at the grill mouth. Comparison of these results with modeling predictions will be presented in a companion paper.

  20. Pacific Array

    NASA Astrophysics Data System (ADS)

    Kawakatsu, H.; Takeo, A.; Isse, T.; Nishida, K.; Shiobara, H.; Suetsugu, D.

    2014-12-01

    Based on our recent results on broadband ocean bottom seismometry, we propose a next generation large-scale array experiment in the ocean. Recent advances in ocean bottom broadband seismometry (e.g., Suetsugu & Shiobara, 2014, Annual Review EPS), together with advances in the seismic analysis methodology, have now enabled us to resolve the regional 1-D structure of the entire lithosphere/asthenosphere system, including seismic anisotropy (both radial and azimuthal), with deployments of ~10-15 broadband ocean bottom seismometers (BBOBSs) (namely "ocean-bottom broadband dispersion survey"; Takeo et al., 2013, JGR; Kawakatsu et al., 2013, AGU; Takeo, 2014, Ph.D. Thesis; Takeo et al., 2014, JpGU). Having ~15 BBOBSs as an array unit for 2-year deployment, and repeating such deployments in a leap-frog way (an array of arrays) for a decade or so would enable us to cover a large portion of the Pacific basin. Such efforts, not only by giving regional constraints on the 1-D structure, but also by sharing waveform data for global scale waveform tomography, would drastically increase our knowledge of how plate tectonics works on this planet, as well as how it worked for the past 150 million years. International collaborations might be sought.

  1. Investigation of lower hybrid physics through power modulation experiments on Alcator C-Moda)

    NASA Astrophysics Data System (ADS)

    Schmidt, A.; Bonoli, P. T.; Meneghini, O.; Parker, R. R.; Porkolab, M.; Shiraiwa, S.; Wallace, G.; Wright, J. C.; Harvey, R. W.; Wilson, J. R.

    2011-05-01

    Lower hybrid current drive (LHCD) is an attractive tool for off-axis current profile control in magnetically confined tokamak plasmas and burning plasmas (ITER), because of its high current drive efficiency. The LHCD system on Alcator C-Mod operates at 4.6 GHz, with ~ 1 MW of coupled power, and can produce a wide range of launched parallel refractive index (n||) spectra. A 32 chord, perpendicularly viewing hard x-ray camera has been used to measure the spatial and energy distribution of fast electrons generated by lower hybrid (LH) waves. Square-wave modulation of LH power on a time scale much faster than the current relaxation time does not significantly alter the poloidal magnetic field inside the plasma and thus allows for realistic modeling and consistent plasma conditions for different n|| spectra. Inverted hard x-ray profiles show clear changes in LH-driven fast electron location with differing n||. Boxcar binning of hard x-rays during LH power modulation allows for ~ 1 ms time resolution which is sufficient to resolve the build-up, steady-state, and slowing-down phases of fast electrons. Ray-tracing/Fokker-Planck modeling in combination with a synthetic hard x-ray diagnostic shows quantitative agreement with the x-ray data for high n|| cases. The time histories of hollow x-ray profiles have been used to measure off-axis fast electron transport in the outer half of the plasma, which is found to be small on a slowing down time scale.

  2. MagArray Biochips for Protein and DNA Detection with Magnetic Nanotags: Design, Experiment, and Signal-to-Noise Ratio

    NASA Astrophysics Data System (ADS)

    Osterfeld, Sebastian J.; Wang, Shan X.

    MagArray™ chips contain arrays of magnetic sensors, which can be used to detect surface binding reactions of biological molecules that have been labeled with 10 to 100 nm sized magnetic particles. Although MagArray chips are in some ways similar to fluorescence-based DNA array chips, the use of magnetic labeling tags leads to many distinct advantages, such as better background rejection, no label bleaching, inexpensive chip readers, potentially higher sensitivity, ability to measure multiple binding reactions in homogeneous assays simultaneously and in real-time, and seamless integration with magnetic separation techniques. So far, the technology of MagArray chips has been successfully used to perform quantitative analytic bioassays of both protein and nucleic acid targets. The potential of this technology, especially for point-of-care testing (POCT) and portable molecular diagnostics, appears promising, and it is likely that this technology will see significant further performance gains in the near future.

  3. Spectral broadening of lower hybrid waves produced by parametric instability in current drive experiments of tokamak plasmas

    NASA Astrophysics Data System (ADS)

    Cesario, R.; Cardinali, A.; Castaldo, C.; Paoletti, F.; Fundamenski, W.; Hacquin, S.; JET-EFDA workprogramme contributors

    2006-04-01

    In order to explain the results of the non-inductive current produced in the lower hybrid current drive (LHCD) experiments, a broadening of the radiofrequency (RF) power spectrum coupled to tokamak plasma needs to occur. The presented modelling, supported by diagnostic measurements, shows that the parametric instability (PI) driven by ion sound quasimodes, which occur in the scrape-off plasma layer located near the antenna mouth, produces a significant broadening of the launched LH spectrum. Considering the parameters of LHCD experiments of JET (Joint European Torus), and other machines as well, the PI growth rate is high enough for producing the compensation of the convective losses and, consequently, the broadening of a small fraction (of the order of 10%) of the launched power spectrum. Such a phenomenon is identified to be intrinsic to the RF power coupling in the LHCD experiments. As the principal implication of considering such spectral broadening in modelling the LH deposition profile, experiments of LHCD-sustained internal transport barriers in JET were successfully interpreted, which evidenced the effects of a well-defined LH deposition profile. The present work is important for addressing the long-lasting debate on the problem of the so-called spectral gap in LHCD. The design of LHCD scenarios relevant to the modern fusion research programme, an important requirement of which is the control of the plasma current profile in the outer half of plasma, can be properly achieved by considering PI-induced spectral broadening.

  4. Phase multiplying electronic scanning array

    NASA Technical Reports Server (NTRS)

    Seaton, A. F.

    1969-01-01

    Scanning array was designed with properties of low RF loss and phase control. The array consists of a series of special waveguides, hybrids made up of two variable reactance branch arms for input signals, an edge slot for the difference port, and a sum arm for the unradiated signal.

  5. CdS nanorods/organic hybrid LED array and the piezo-phototronic effect of the device for pressure mapping

    NASA Astrophysics Data System (ADS)

    Bao, Rongrong; Wang, Chunfeng; Dong, Lin; Shen, Changyu; Zhao, Kun; Pan, Caofeng

    2016-04-01

    As widely applied in light-emitting diodes and optical devices, CdS has attracted the attention of many researchers due to its nonlinear properties and piezo-electronic effect. Here, we demonstrate a LED array composed of PEDOT:PSS and CdS nanorods and research the piezo-photonic effect of the array device. The emission intensity of the device depends on the electron-hole recombination at the interface of the p-n junction which can be adjusted using the piezo-phototronic effect and can be used to map the pressure applied on the surface of the device with spatial resolution as high as 1.5 μm. A flexible LED device array has been prepared using a CdS nanorod array on a Au/Cr/kapton substrate. This device may be used in the field of strain mapping using its high pressure spatial-resolution and flexibility.As widely applied in light-emitting diodes and optical devices, CdS has attracted the attention of many researchers due to its nonlinear properties and piezo-electronic effect. Here, we demonstrate a LED array composed of PEDOT:PSS and CdS nanorods and research the piezo-photonic effect of the array device. The emission intensity of the device depends on the electron-hole recombination at the interface of the p-n junction which can be adjusted using the piezo-phototronic effect and can be used to map the pressure applied on the surface of the device with spatial resolution as high as 1.5 μm. A flexible LED device array has been prepared using a CdS nanorod array on a Au/Cr/kapton substrate. This device may be used in the field of strain mapping using its high pressure spatial-resolution and flexibility. Electronic supplementary information (ESI) available. See DOI: 10.1039/c6nr00431h

  6. Fabrication of high performance flexible micro-supercapacitor arrays with hybrid electrodes of MWNT/V2O5 nanowires integrated with a SnO2 nanowire UV sensor

    NASA Astrophysics Data System (ADS)

    Kim, Daeil; Yun, Junyeong; Lee, Geumbee; Ha, Jeong Sook

    2014-09-01

    We report on the on-chip fabrication of high performance flexible micro-supercapacitor (MSC) arrays with hybrid electrodes of multi-walled carbon nanotube (MWNT)/V2O5 nanowire (NW) composites and a solid electrolyte, which could power the SnO2 NW UV sensor integrated on the same flexible substrate. The patterned MSC using hybrid electrodes of MWNT/V2O5 NW composites with 10 vol% of V2O5 NWs exhibited excellent electrochemical performance with a high volume capacitance of 80 F cm-3 at a scan rate of 10 mV s-1 in a PVA-LiCl electrolyte and good cycle performance to maintain 82% of the capacitance after 10 000 cycles at a current density of 11.6 A cm-3. The patterned MSC also showed an excellent energy density of 6.8 mW h cm-3, comparable to that of a Li-thin film battery (1-10 mW h cm-3), and a power density of 80.8 W cm-3 comparable to that of state-of-the-art MSCs. In addition, the flexible MSC array on a PET substrate showed mechanical stability over bending with a bending radius down to 1.5 mm under both compressive and tensile stress. Even after 1000 bending cycles at a bending radius of 7 mm, 94% of the initial capacitance was maintained. Furthermore, we have shown the operation of a SnO2 NW UV sensor using such a fabricated MSC array integrated into the same circuit on the PET substrate.We report on the on-chip fabrication of high performance flexible micro-supercapacitor (MSC) arrays with hybrid electrodes of multi-walled carbon nanotube (MWNT)/V2O5 nanowire (NW) composites and a solid electrolyte, which could power the SnO2 NW UV sensor integrated on the same flexible substrate. The patterned MSC using hybrid electrodes of MWNT/V2O5 NW composites with 10 vol% of V2O5 NWs exhibited excellent electrochemical performance with a high volume capacitance of 80 F cm-3 at a scan rate of 10 mV s-1 in a PVA-LiCl electrolyte and good cycle performance to maintain 82% of the capacitance after 10 000 cycles at a current density of 11.6 A cm-3. The patterned MSC also

  7. Photolithographic Synthesis of High-Density DNA and RNA Arrays on Flexible, Transparent, and Easily Subdivided Plastic Substrates.

    PubMed

    Holden, Matthew T; Carter, Matthew C D; Wu, Cheng-Hsien; Wolfer, Jamison; Codner, Eric; Sussman, Michael R; Lynn, David M; Smith, Lloyd M

    2015-11-17

    The photolithographic fabrication of high-density DNA and RNA arrays on flexible and transparent plastic substrates is reported. The substrates are thin sheets of poly(ethylene terephthalate) (PET) coated with cross-linked polymer multilayers that present hydroxyl groups suitable for conventional phosphoramidite-based nucleic acid synthesis. We demonstrate that by modifying array synthesis procedures to accommodate the physical and chemical properties of these materials, it is possible to synthesize plastic-backed oligonucleotide arrays with feature sizes as small as 14 μm × 14 μm and feature densities in excess of 125 000/cm(2), similar to specifications attainable using rigid substrates such as glass or glassy carbon. These plastic-backed arrays are tolerant to a wide range of hybridization temperatures, and improved synthetic procedures are described that enable the fabrication of arrays with sequences up to 50 nucleotides in length. These arrays hybridize with S/N ratios comparable to those fabricated on otherwise identical arrays prepared on glass or glassy carbon. This platform supports the enzymatic synthesis of RNA arrays and proof-of-concept experiments are presented showing that the arrays can be readily subdivided into smaller arrays (or "millichips") using common laboratory-scale laser cutting tools. These results expand the utility of oligonucleotide arrays fabricated on plastic substrates and open the door to new applications for these important bioanalytical tools. PMID:26494264

  8. Fabrication of high performance flexible micro-supercapacitor arrays with hybrid electrodes of MWNT/V2O5 nanowires integrated with a SnO2 nanowire UV sensor.

    PubMed

    Kim, Daeil; Yun, Junyeong; Lee, Geumbee; Ha, Jeong Sook

    2014-10-21

    We report on the on-chip fabrication of high performance flexible micro-supercapacitor (MSC) arrays with hybrid electrodes of multi-walled carbon nanotube (MWNT)/V2O5 nanowire (NW) composites and a solid electrolyte, which could power the SnO2 NW UV sensor integrated on the same flexible substrate. The patterned MSC using hybrid electrodes of MWNT/V2O5 NW composites with 10 vol% of V2O5 NWs exhibited excellent electrochemical performance with a high volume capacitance of 80 F cm(-3) at a scan rate of 10 mV s(-1) in a PVA-LiCl electrolyte and good cycle performance to maintain 82% of the capacitance after 10,000 cycles at a current density of 11.6 A cm(-3). The patterned MSC also showed an excellent energy density of 6.8 mW h cm(-3), comparable to that of a Li-thin film battery (1-10 mW h cm(-3)), and a power density of 80.8 W cm(-3) comparable to that of state-of-the-art MSCs. In addition, the flexible MSC array on a PET substrate showed mechanical stability over bending with a bending radius down to 1.5 mm under both compressive and tensile stress. Even after 1000 bending cycles at a bending radius of 7 mm, 94% of the initial capacitance was maintained. Furthermore, we have shown the operation of a SnO2 NW UV sensor using such a fabricated MSC array integrated into the same circuit on the PET substrate. PMID:25184811

  9. Charge collection enhancement by incorporation of gold-silica core-shell nanoparticles into P3HT:PCBM/ZnO nanorod array hybrid solar cells.

    PubMed

    Wang, Ting-Chung; Su, Yen-Hsun; Hung, Yun-Kai; Yeh, Chen-Sheng; Huang, Li-Wen; Gomulya, Widianta; Lai, Lai-Hung; Loi, Maria A; Yang, Jih-Sheng; Wu, Jih-Jen

    2015-08-14

    In this work, gold-silica core-shell (Au@silica) nanoparticles (NPs) with various silica-shell thicknesses are incorporated into P3HT:PCBM/ZnO nanorod (NR) hybrid solar cells. Enhancement in the short-circuit current density and the efficiency of the hybrid solar cells is attained with the appropriate addition of Au@silica NPs regardless of the silica-shell thickness. Compared to the P3HT:PCBM/ZnO NR hybrid solar cell, a 63% enhancement in the efficiency is achieved by the P3HT:PCBM/Au@silica NP/ZnO NR hybrid solar cell. The finite difference time domain simulations indicate that the strength of the Fano resonance, i.e., the electric field of the quasi-static asymmetric quadrupole, on the surface of Au@silica NPs in the P3HT:PCBM/ZnO NR hybrid significantly decreases with increasing thickness of the silica shell. Raman characterization reveals that the degree of P3HT order increases when Au@silica NPs are incorporated into the P3HT:PCBM/ZnO NR hybrid. The charge separation at the interface between P3HT and PCBM as well as the electron transport in the active layer are retarded by the electric field of the Fano resonance. Nevertheless, the prolongation of the electron lifetime and the reduction of the electron transit time in the P3HT:PCBM/ZnO NR hybrid solar cells, which result in an enhancement of electron collection, are achieved by the addition of Au@silica NPs. This may be attributed to the improvement in the degree of P3HT order and connectivity of PCBM when Au@silica NPs are incorporated into the P3HT:PCBM active layer. PMID:26159896

  10. Thomson scattering diagnostic system design for the Compact Toroidal Hybrid experiment

    SciTech Connect

    Traverso, P. J. Maurer, D. A.; Ennis, D. A.; Hartwell, G. J.; Goforth, M. M.; Loch, S. D.; Pearce, A. J.; Cianciosa, M. R.

    2014-11-15

    A new Thomson scattering system using standard commercially available components has been designed for the non-axisymmetric plasmas of the Compact Toroidal Hybrid (CTH). The beam, generated by a frequency doubled Continuum PL DLS 2 J Nd:YAG laser, is passed vertically through an entrance Brewster window and an aperturing baffle system to minimize the stray laser light that could enter the collection optics. The beam line has been designed with an 8 m propagation distance to the mid-plane of the CTH device with the beam diameter kept less than 3 mm inside the plasma volume. The beam exits the vacuum system through another Brewster window and enters a beam dump, again to minimize the stray light in the vacuum chamber. Light collection, spectral processing, and signal detection are accomplished with an f/#∼ 1 aspheric lens, a commercially available Holospec f/1.8 spectrometer, and an Andor iStar DH740-18U-C3 image intensified camera. Spectral rejection of stray laser light, if needed, can be performed with the use of an optional interference filter at the spectrometer input. The system has been developed for initial single point measurements of plasmas with core electron temperatures of approximately 20–300 eV and densities of 5 × 10{sup 18} to 5 × 10{sup 19} m{sup −3} dependent upon operational scenario.

  11. Design and implementation of a Thomson scattering diagnostic for the Compact Toroidal Hybrid Experiment

    NASA Astrophysics Data System (ADS)

    Traverso, P. J.; Maurer, D. A.; Ennis, D. A.; Hartwell, G. J.; Goforth, M. M.; Loch, S. D.; Pearce, A. J.; Cianciosa, M. R.

    2014-10-01

    A Thomson scattering system using standard commercially available components has been designed for the non-axisymmetric plasmas of the Compact Toroidal Hybrid (CTH). The initial system takes a single point measurement and will be used to assess options for an upgrade to a multi-point system providing electron temperature and density profiles. This single point measurement will reduce the uncertainty in the reconstructed peak pressure by an order of magnitude for both ohmically driven, current-carrying plasmas and future gyrotron-heated stellarator plasmas. A principle design goal is to minimize stray laser light, geometrically on the machine side and spectrally on the collection side, to allow measurements of both full and half Thomson scattered spectral profiles. The beam, generated by a frequency doubled Continuum 2 J Nd:YaG laser, is passed vertically through an entrance Brewster window and an aperturing baffle system to minimize stray light. Light collection, spectral processing, and signal detection are accomplished with an f / # ~ 1 aspheric lens, a Holospec f/1.8 spectrometer, and an Andor iStar DH740-18U-C3 image intensified camera. The estimated number of scattered photons per channel will be of the order of 5 ×103 with a signal to noise ratio of S / N = 19 This work is supported by U.S. Department of Energy Grant No. DE-FG02-00ER54610.

  12. Thomson scattering diagnostic system design for the Compact Toroidal Hybrid experiment.

    PubMed

    Traverso, P J; Maurer, D A; Ennis, D A; Hartwell, G J; Goforth, M M; Loch, S D; Pearce, A J; Cianciosa, M R

    2014-11-01

    A new Thomson scattering system using standard commercially available components has been designed for the non-axisymmetric plasmas of the Compact Toroidal Hybrid (CTH). The beam, generated by a frequency doubled Continuum PL DLS 2 J Nd:YAG laser, is passed vertically through an entrance Brewster window and an aperturing baffle system to minimize the stray laser light that could enter the collection optics. The beam line has been designed with an 8 m propagation distance to the mid-plane of the CTH device with the beam diameter kept less than 3 mm inside the plasma volume. The beam exits the vacuum system through another Brewster window and enters a beam dump, again to minimize the stray light in the vacuum chamber. Light collection, spectral processing, and signal detection are accomplished with an f/#∼ 1 aspheric lens, a commercially available Holospec f/1.8 spectrometer, and an Andor iStar DH740-18U-C3 image intensified camera. Spectral rejection of stray laser light, if needed, can be performed with the use of an optional interference filter at the spectrometer input. The system has been developed for initial single point measurements of plasmas with core electron temperatures of approximately 20-300 eV and densities of 5 × 10(18) to 5 × 10(19) m(-3) dependent upon operational scenario. PMID:25430265

  13. Experiments, modeling and simulation of the magnetic behavior of inhomogeneously coated nickel/aluminum hybrid foams

    NASA Astrophysics Data System (ADS)

    Jung, A.; Klis, D.; Goldschmidt, F.

    2015-03-01

    Open-cell metal foams are used as lightweight construction elements, energy absorbers or as support for catalytic coatings. Coating of open-cell metal foams is not only used for catalytic applications, but it leads also to tremendous increase in stiffness and energy absorption capacity. A non-line of sight coating technique for complex 3D structures is electrodeposition. Unfortunately, due to the 3D porosity and the related problems in mass transport limitation during the deposition, it is not possible to produce homogeneously coated foams. In the present contribution, we present a semi-non-destructive technique applicable to determine the coating thickness distribution of magnetic coatings by measuring the remanent magnetic field of coated foams. In order to have a closer look at the mass transport mechanism, a numerical model was developed to predict the field scans for different coating thickness distributions in the foams. For long deposition times the deposition reaches a steady state whereas a Helmholtz equation is sufficient to predict the coating thickness distribution. The applied current density could be identified as the main influencing parameter. Based on the developed model, it is possible to improve the electrodeposition process and hence the homogeneity in the coating thickness of coated metal foams. This leads to enhanced mechanical properties of the hybrid foams and contributes to better and resource-efficient energy absorbers and lightweight materials.

  14. Smell Nanobiosensors: Hybrid systems based on the electrical response to odorant capture Theory And Experiment

    NASA Astrophysics Data System (ADS)

    Alfinito, Eleonora; Pennetta, Cecilia; Reggiani, Lino

    2009-05-01

    Mammalian olfactory system is the bio-archetype of smell sensor devices. It is based on a very articulated mechanism which translate the odorant capture information performed by the olfactory receptors (ORs) into a code. Finally, the code is sent to the brain for aroma recognition. Our aim is to partially mimick this system to produce a biosensor on nanometric scale. The active part of the device is constituted of nanosomes containing specific ORs. Each nanosome is interfaced with nanoelectrodes and the odorant capture is converted into an electric signal. Specifically, the electrical response is correlated with the conformational change that a single OR undergoes when it captures a specific odorant molecule. An array of nanodevices should be able to produce specific response profiles. In this paper we present a possible theoretical framework in which the experimental results should be embedded. It consists of the description of the protein in terms of an impedance network able to simulate the electrical characteristics associated with the protein topology.

  15. Molecular Dissection Using Array Comparative Genomic Hybridization and Clinical Evaluation of An Infertile Male Carrier of An Unbalanced Y;21 Translocation: A Case Report and Review of The Literature.

    PubMed

    Orrico, Alfredo; Marseglia, Giuseppina; Pescucci, Chiara; Cortesi, Ambra; Piomboni, Paola; Giansanti, Andrea; Gerundino, Francesca; Ponchietti, Roberto

    2016-01-01

    Chromosomal defects are relatively frequent in infertile men however, translocations between the Y chromosome and autosomes are rare and less than 40 cases of Y-autosome translocation have been reported. In particular, only three individuals has been described with a Y;21 translocation, up to now. We report on an additional case of an infertile man in whom a Y;21 translocation was associated with the deletion of a large part of the Y chromosome long arm. Applying various techniques, including conventional cytogenetic procedures, fluorescence in situ hybridisation (FISH) analysis and array comparative genomic hybridization (array-CGH) studies, we identified a derivative chromosome originating from a fragment of the short arm of the chromosome Y translocated on the short arm of the 21 chromosome. The Y chromosome structural rearrangement resulted in the intactness of the entire short arm, including the sex-determining region Y (SRY) and the short stature homeobox (SHOX) loci, although translocated on the 21 chromosome, and the loss of a large part of the long arm of the Y chromosome, including azoospermia factor-a (AZFa), AZFb, AZFc and Yq heterochromatin regions. This is the first case in which a (Yp;21p) translocation has been ascertained using an array-CGH approach, thus reporting details of such a rearrangement at higher resolution. PMID:26985348

  16. Performance of the Tibet hybrid experiment (YAC-II + Tibet-III + MD) to measure the energy spectra of the light primary cosmic rays at energies 50-10,000 TeV

    NASA Astrophysics Data System (ADS)

    Huang, J.; Zhai, L. M.; Chen, D.; Shibata, M.; Katayose, Y.; Zhang, Ying; Liu, J. S.; Chen, Xu; Hu, X. B.; Zhang, X. Y.; Jia, H. Y.; Danzengluobu; Ohnishi, M.; Takita, M.

    2015-06-01

    A new hybrid detector system has been constructed by the Tibet ASγ collaboration at Tibet, China, since 2014 to measure the chemical composition of cosmic rays around the knee in the wide energy range. They consist of an air-shower-core detector-grid (YAC-II) to detect high energy electromagnetic component, the Tibet air-shower array (Tibet-III) and a large underground water-Cherenkov muon-detector array (MD). We have carried out a detailed air-shower Monte Carlo (MC) simulation to study the performance of the hybrid detectors by using CORSIKA (version 6.204), which includes QGSJET01c and SIBYLL2.1 hadronic interaction models. Assumed primary cosmic ray models are based on helium poor, helium rich and Gaisser's fit compositions around the knee. All detector responses are calculated using Geant4 (version 9.5) according to the real detector configurations and the MC events are reconstructed by the same procedure as the experimental data analysis. The energy determination is made by lateral density fitting (LDF) method using modified NKG function and the separation of the light components (proton, helium) is made by means of the artificial neural network (ANN) method and the random forest (RF) method. The systematic errors of the spectra of proton and helium caused by each steps of the analysis procedure are investigated including the dependence of the MC data on the hadronic interaction models and the primary composition models, and the algorithms for the primary mass identification. The systematic errors of the flux to be obtained by the new experiment are summarized as less than 30% in total. Our results show that the new hybrid experiment is powerful enough to study the chemical composition of the cosmic rays, in particular, to obtain the light-component spectra of the primary cosmic rays in 50-10,000 TeV energy range overlapping to the direct observation data at low energy side and ground-based indirect observations at high energy side. It is possible in this

  17. Asymmetric van der Waals Forces Drive Orientation of Compositionally Anisotropic Nanocylinders within Smectic Arrays: Experiment and Simulation

    PubMed Central

    Smith, Benjamin D.; Fichthorn, Kristen A.; Kirby, David J.; Quimby, Lisa M.; Triplett, Derek A.; González, Pedro; Hernández, Darimar; Keating, Christine D.

    2014-01-01

    Understanding how micro- and nanoparticles interact is important for achieving bottom-up assembly of desired structures. Here, we examine the self-assembly of two-component, compositionally asymmetric nanocylinders that sediment from solution onto a solid surface. These particles spontaneously formed smectic arrays. Within the rows of an array, nanocylinders tended to assemble such that neighboring particles had the same orientation of their segments. As a probe of interparticle interactions, we classified nanocylinder alignments by measuring the segment orientations of many sets of neighboring particles. Monte Carlo simulations incorporating an exact expression for the van der Waals (vdW) energy indicate that differences in the vdW interactions, even when small, are the key factor in producing observed segment alignment. These results point to asymmetrical vdW interactions as a potentially powerful means of controlling orientation in multicomponent cylinder arrays, and suggest that designing for these interactions could yield new ways to control self-assembly. PMID:24308771

  18. The theory and experiment of very-long-wavelength 256×1 GaAs/Al x Ga1- x As quantum well infrared detector linear arrays

    NASA Astrophysics Data System (ADS)

    Guo, Fangmin; Li, Ning; Xiong, Dayuan; Zhen, Honglou; Xu, Xiangyan; Hou, Ying; Ding, Ruijun; Lu, Wei; Huang, Qi; Zhou, Junming

    2008-07-01

    The 256×1 linear array of multiple quantum wells infrared photodetector (QWIP) is designed and fabricated for the peak response wavelength at λ P = 14.6 μm. The response spectral width is bigger than 2.2 μm. The two-dimensional (2D) diffractive coupling grating has been formed on the top QWIP photosensitive pixel for coupling the infrared radiation to the infrared detective layers. The performance of the device at V B = 3 V and T = 45 K has the responsibility 4.28×10-2 (A/W), the blackbody detectivity D b* = 5.14×109 (cm·Hz1/2/W), and the peak detectivity D λ * = 4.24× 1010 (cm·Hz1/2/W). The sensor pixels are connected with CMOS read out circuit (ROC) hybridization by indium bumps. When integral time is 100 μs, the linear array has the effective pixel of QWIP FPA N ef of 99.2%, the average responsibility overline R (V/W) of 3.48×106 (V/W), the average peak detectivity D λ * of 8.29×109 (cm·Hz1/2/W), and the non-uniformity UR of 5.83%. This device is ready for the thermal image application.

  19. Combustion Experiment to Evaluate a LOX Vaporization Nozzle for a Swirling-Oxidizer-Flow-Type Hybrid Rocket Engine with a 1500N-Thrust

    NASA Astrophysics Data System (ADS)

    Kitagawa, Koki; Sakurazawa, Toshiaki; Yuasa, Saburo

    The authors have proposed a LOX vaporization nozzle for swirling-oxidizer-flow-type hybrid rocket engines to increase engine performance. In this study, we developed the LOX vaporization nozzle for this type of a hybrid rocket engine with a 1500N-thrust. Vaporization experiments, using a LOX supply system for the nozzle to be independent of a GOX supply system for the engine, were conducted. The test runs at little oxygen mass flow rates and low combustion pressures at the design point showed that LOX could be vaporized safely through the nozzle. It was confirmed that the design of the LOX vaporization nozzle was proper. Vaporization and burning experiments using vaporized O2 through the LOX vaporization nozzle showed that reliable and rapid ignition and stable combustion without combustion oscillation were achieved. The LOX vaporization nozzle increased the engine performance of the swirling-oxidizer- flow-type hybrid rocket engine.

  20. Coupling characteristics of the ITER-relevant lower hybrid antenna in Tore Supra: experiments and modelling

    NASA Astrophysics Data System (ADS)

    Preynas, M.; Ekedahl, A.; Fedorczak, N.; Goniche, M.; Guilhem, D.; Gunn, J. P.; Hillairet, J.; Litaudon, X.; Achard, J.; Berger-By, G.; Belo, J.; Corbel, E.; Delpech, L.; Ohsako, T.; Prou, M.

    2011-02-01

    A new concept of lower hybrid antenna for current drive has been proposed for ITER (Bibet et al 1995 Nucl. Fusion 35 1213-23): the passive active multijunction (PAM) antenna that relies on a periodic combination of active and passive waveguides. An actively cooled PAM antenna at 3.7 GHz has recently been installed on the tokamak Tore Supra. This paper summarizes the comprehensive experimental characterization of the coupling properties of the PAM antenna to the Tore Supra plasmas. In this paper, the electromagnetic properties of the antenna are measured at a reduced power (<1 MW) to allow a systematic comparison with linear wave coupling theory and the associated modelling based on the linear ALOHA code. In a wide range of edge electron densities at the antenna aperture (spanning a factor 20 from 0.5 × nc to 10 × nc where nc is the slow wave density cut-off, nc = 1.7 × 1017 m-3 at 3.7 GHz) and antenna phasing, the ALOHA simulations reproduce the experimental results observed on Tore Supra. In addition, reduced power reflection coefficients (<5%) are measured at a low edge density, close to nc, i.e. in the range 0.5-3 × nc. Measurement and analysis with ALOHA of the antenna-plasma scattering matrices provide explanation of the good coupling properties of the PAM antenna close to nc by highlighting the crucial role of the slow wave intercoupling between active and passive waveguides through the plasma edge. This detailed validation of the coupling modelling is an important step towards the validation of the PAM concept in view of further optimizing the electromagnetic properties of the future ITER antenna.