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Sample records for arthur kill project

  1. Evaluation of dredged material proposed for ocean disposal from Arthur Kill Project Area, New York

    SciTech Connect

    Gruendell, B.D.; Barrows, E.S.; Borde, A.B.

    1997-01-01

    The objective of the bioassay reevaluation of Arthur Kill Federal Project was to reperform toxicity testing on proposed dredged material following current ammonia reduction protocols. Arthur Kill was one of four waterways sampled and evaluated for dredging and disposal in April 1993. Sediment samples were recollected from the Arthur Kill Project areas in August 1995. Tests and analyses were conducted according to the manual developed by the USACE and the U.S. Environmental Protection Agency (EPA), Evaluation of Dredged Material Proposed for Ocean Disposal (Testing Manual), commonly referred to as the {open_quotes}Green Book,{close_quotes} and the regional manual developed by the USACE-NYD and EPA Region II, Guidance for Performing Tests on Dredged Material to be Disposed of in Ocean Waters. The reevaluation of proposed dredged material from the Arthur Kill project areas consisted of benthic acute toxicity tests. Thirty-three individual sediment core samples were collected from the Arthur Kill project area. Three composite sediments, representing each reach of the area proposed for dredging, was used in benthic acute toxicity testing. Benthic acute toxicity tests were performed with the amphipod Ampelisca abdita and the mysid Mysidopsis bahia. The amphipod and mysid benthic toxicity test procedures followed EPA guidance for reduction of total ammonia concentrations in test systems prior to test initiation. Statistically significant acute toxicity was found in all Arthur Kill composites in the static renewal tests with A. abdita, but not in the static tests with M. bahia. Statistically significant acute toxicity and a greater than 20% increase in mortality over the reference sediment was found in the static renewal tests with A. abdita. M. bahia did not show statistically significant acute toxicity or a greater than 10% increase in mortality over reference sediment in static tests. 5 refs., 2 figs., 2 tabs.

  2. 33 CFR 117.702 - Arthur Kill.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Arthur Kill. 117.702 Section 117.702 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements New Jersey § 117.702 Arthur Kill. (a) The draw of the Arthur Kill (AK) Railroad Bridge shall be...

  3. GOETHALS BRIDGE FROM NORTH SIDE OVER ARTHUR KILL. RAILROAD BRIDGE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    GOETHALS BRIDGE FROM NORTH SIDE OVER ARTHUR KILL. RAILROAD BRIDGE IN FOREGROUND - Goethals Bridge, Spanning Arthur Kill from New Jersey to Staten Island, Staten Island (subdivision), Richmond County, NY

  4. 78 FR 43063 - Drawbridge Operation Regulations; Arthur Kill, NY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-19

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Arthur Kill, NY AGENCY: Coast Guard... District, has issued a temporary deviation from the regulations governing the operation of the Arthur Kill AK Railroad Bridge across Arthur Kill, mile 11.6, between Staten Island, New York and Elizabeth,...

  5. Navigation study on improvements to existing federal navigation channels Arthur Kill Channel, Howland Hook Marine Terminal, Staten Island, New York

    SciTech Connect

    Not Available

    1985-06-01

    Improvements to the Arthur Kill Channel from the confluence of the Kill Van Kull Channel, the Arthur Kill Channel, and Newark Bay, along the Arthur Kill to the vicinity of Howland Hook Marine Terminal on Staten Island, New York are proposed. In addition, the study area was extended south from Howland Hook Terminal for approximately one mile in order to serve two oil terminals. The recommended improvements would include deepening to various depths down to 45 feet mean low water (MLW), widening the channel for unrestricted two-way traffic, and the creation of a turning basin. Specifically, a 41-foot MLW deep channel would be dredged in the previously authorized 35-foot MLW project in the Arthur Kill Channel from its confluence with the Newark Bay and Kill Van Kull channels to the Howland Hook Marine Terminal for a distance of approximately 2.1 miles. Also recommended are selected widenings and realignments of the channel at a depth of 41 feet in the interest of navigational safety. Additionally, a 40-foot MLW channel is proposed in the previously authorized 35-foot MLW project in the Arthur Kill Channel from the Howland Hook Marine Terminal to the Exxon Bayway and Gulfport facilities for a distance of approximately one mile. The channel would be selectively realigned to a 40-foot depth for navigational safety. No final determination has been made regarding the disposal of dredged material due to the uncertainty of available upland sites at this time. The turning basin would lie in the Kill Van Kull Channel at Bergen Point, where vessels turn from Kill Van Kull into Arthur Kill and Newark Bay. Total cost of the recommended plan is $49.4 million; the benefit-cost ratio is 4.35. The plan would take 4 years for completion and would have a projected life of 50 years.

  6. 77 FR 1023 - Regulated Navigation Area; Arthur Kill, NY and NJ

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-09

    ... Arthur Kill. An earlier TIR added the basic RNA regulation for that waterway: 33 CFR 165.T01-0727 (76 FR... Federal Register (73 FR 3316). Public Meeting We do not now plan to hold a public meeting within the... amending the Regulated Navigation Area (RNA) in the navigable waters of the Arthur Kill in New York and...

  7. 76 FR 36914 - Astoria Generating Company, L.P., NRG Power Marketing LLC, Arthur Kill Power LLC, Astoria Gas...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Astoria Generating Company, L.P., NRG Power Marketing LLC, Arthur Kill Power LLC, Astoria Gas Turbine Power LLC, Dunkirk Power LLC, Huntley Power LLC, Oswego Harbor Power LLC, TC Ravenswood, LLC, v. New York...

  8. 76 FR 36910 - Astoria Generating Company, L.P., NRG Power Marketing LLC, Arthur Kill Power LLC, Astoria Gas...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Astoria Generating Company, L.P., NRG Power Marketing LLC, Arthur Kill Power LLC, Astoria Gas Turbine Power LLC, Dunkirk Power LLC, Huntley Power LLC, Oswego Harbor Power LLC, TC Ravenswood, LLC. v. New York...

  9. 76 FR 34692 - Astoria Generating Company, L.P., NRG Power Marketing LLC, Arthur Kill Power LLC, Astoria Gas...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-14

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Astoria Generating Company, L.P., NRG Power Marketing LLC, Arthur Kill Power LLC, Astoria Gas Turbine Power LLC, Dunkirk Power LLC, Huntley Power LLC, Oswego Harbor Power LLC, TC Ravenswood, LLC; v. New York...

  10. 33 CFR 165.T01-0727 - Regulated Navigation Area; Arthur Kill, NY and NJ.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (NAD 83). (b) Regulations. (1) The general regulations contained in 33 CFR 165.13 apply. (2) All... requirements through VTS measures, as per 33 CFR 161.11. (9) Suspension of enforcement: the Captain of the Port... Kill, NY and NJ. 165.T01-0727 Section 165.T01-0727 Navigation and Navigable Waters COAST...

  11. 33 CFR 165.T01-0727 - Regulated Navigation Area; Arthur Kill, NY and NJ.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (NAD 83). (b) Regulations. (1) The general regulations contained in 33 CFR 165.13 apply. (2) All... requirements through VTS measures, as per 33 CFR 161.11. (9) Suspension of enforcement: the Captain of the Port... Kill, NY and NJ. 165.T01-0727 Section 165.T01-0727 Navigation and Navigable Waters COAST...

  12. Comparison of benthic invertebrate assemblages at Spartina alterniflora marshes reestablished after an oil spill and existing marshes in the Arthur Kill (NY/NJ).

    PubMed

    Vitaliano, Joseph J; Reid, Robert N; Frame, Ann B; Packer, David B; Arlen, Linda; Sacco, John N

    2002-10-01

    In January 1990, an oil spill damaged salt marshes along the banks of the Arthur Kill (New York and New Jersey, USA). In the years following the spill, Spartina alterniflora seedlings were planted at a number of the oil damaged sites and successfully reestablished at these sites. In 1996, the National Marine Fisheries Service began a study to compare the benthic invertebrate assemblages at the reestablished S. alterniflora marshes to those at nearby existing marshes in the Arthur Kill. Oligochaetes, nematodes, and the small tube-building polychaete, Manayunkia aestuarina were the dominant taxa in the study. Significant differences were found in the abundances of all invertebrate individuals, oligochaetes, and nematodes between the September and May sampling times but not between reestablished and existing marshes. Although benthic invertebrate community structure was similar at reestablished and existing marshes three to four years after planting, the functional similarity of these marshes was not assessed in this study. PMID:12474971

  13. Why bad projects are so hard to kill.

    PubMed

    Royer, Isabelle

    2003-02-01

    Even at the prototype stage, experts were saying the technology was obsolete. Yet, in the face of tepid consumer response, the company stubbornly kept increasing production capacity and developing new models. By the time it was finally killed, the initiative had cost the company an astounding $580 million and had tied up resources for 14 years. The product was RCA's SelectaVision videodisc recorder, and its story is hardly unique. Companies make similar mistakes--if on a somewhat smaller scale--all the time. But why? No one comes to work saying, "I'm going to pursue a project that will waste my company millions of dollars." Quite the opposite. They come to work full of excitement about a project they believe in. And that, surprisingly, can be the root of all the trouble--a fervent belief in the inevitability of a project's ultimate success. Starting, naturally enough, with a project's champion, this faith can spread throughout the organization, leading everyone to believe collectively in the product's viability and to view any signs of impending doom merely as temporary setbacks. This phenomenon is documented here in two chillingly detailed case studied, one involving Essilor, the world's largest maker of corrective lenses for eyeglasses, and the other involving Lafarge, the largest producer of building materials. By counterexample, they point the way toward avoiding such morasses: assembling project teams not entirely composed of like-minded people and putting in place--and sticking to--well-defined review processes. Both cases also show that if it takes a project champion to get a project up and running, it may take a new kind of organizational player--an "exit champion"--to push an irrationally exuberant organization to admit when enough is enough. PMID:12577652

  14. Deployment of a Prototype Plant GFP Imager at the Arthur Clarke Mars Greenhouse of the Haughton Mars Project

    PubMed Central

    Paul, Anna-Lisa; Bamsey, Matthew; Berinstain, Alain; Braham, Stephen; Neron, Philip; Murdoch, Trevor; Graham, Thomas; Ferl, Robert J.

    2008-01-01

    The use of engineered plants as biosensors has made elegant strides in the past decades, providing keen insights into the health of plants in general and particularly in the nature and cellular location of stress responses. However, most of the analytical procedures involve laboratory examination of the biosensor plants. With the advent of the green fluorescence protein (GFP) as a biosensor molecule, it became at least theoretically possible for analyses of gene expression to occur telemetrically, with the gene expression information of the plant delivered to the investigator over large distances simply as properly processed fluorescence images. Spaceflight and other extraterrestrial environments provide unique challenges to plant life, challenges that often require changes at the gene expression level to accommodate adaptation and survival. Having previously deployed transgenic plant biosensors to evaluate responses to orbital spaceflight, we wished to develop the plants and especially the imaging devices required to conduct such experiments robotically, without operator intervention, within extraterrestrial environments. This requires the development of an autonomous and remotely operated plant GFP imaging system and concomitant development of the communications infrastructure to manage dataflow from the imaging device. Here we report the results of deploying a prototype GFP imaging system within the Arthur Clarke Mars Greenhouse (ACMG) an autonomously operated greenhouse located within the Haughton Mars Project in the Canadian High Arctic. Results both demonstrate the applicability of the fundamental GFP biosensor technology and highlight the difficulties in collecting and managing telemetric data from challenging deployment environments.

  15. 33 CFR 117.702 - Arthur Kill.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... shall maintain a dedicated telephone hot line for vessel operators to call the bridge in advance to coordinate anticipated bridge closures. The telephone hot line number shall be posted on signs at the bridge... bridge, by calling the designated telephone hot line. (d) The bridge shall not be closed for the...

  16. 33 CFR 117.702 - Arthur Kill.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... shall maintain a dedicated telephone hot line for vessel operators to call the bridge in advance to coordinate anticipated bridge closures. The telephone hot line number shall be posted on signs at the bridge... bridge, by calling the designated telephone hot line. (d) The bridge shall not be closed for the...

  17. 33 CFR 117.702 - Arthur Kill.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... shall maintain a dedicated telephone hot line for vessel operators to call the bridge in advance to coordinate anticipated bridge closures. The telephone hot line number shall be posted on signs at the bridge... bridge, by calling the designated telephone hot line. (d) The bridge shall not be closed for the...

  18. 33 CFR 117.702 - Arthur Kill.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... shall maintain a dedicated telephone hot line for vessel operators to call the bridge in advance to coordinate anticipated bridge closures. The telephone hot line number shall be posted on signs at the bridge... bridge, by calling the designated telephone hot line. (d) The bridge shall not be closed for the...

  19. NASA Sees Hurricane Arthur's Fireworks

    NASA Video Gallery

    On July 3, NASA's TRMM satellite passed over Arthur and saw intense bands of thunderstorms north of Arthur's well defined eye dropping rainfall at a rate of over 98.4 mm (3.9 inches) per hour. Thos...

  20. Arthur: A Personalized Instructional System.

    ERIC Educational Resources Information Center

    Gilbert, Juan E.; Han, C. Y.

    2002-01-01

    Examined whether there was a significant difference in learner outcomes from the use of Arthur (Gilbert & Han, 1999), a computer-based adaptive instructional system that provides personalized instruction to each learner. Found that Arthur does provide a significant difference in learner outcomes. (EV)

  1. Faces of Marshall: Arthur Brown

    NASA Video Gallery

    Several Marshall employees were interviewed as part of Marshall's 50th Anniversary activities. Metallurgist Arthur Brown shares how his high school drafting and welding success led him to a NASA ca...

  2. Port Arthur Alive: Exploring Past and Present, 3. Background.

    ERIC Educational Resources Information Center

    Tasmanian Education Dept., Hobart (Australia).

    Part 3 of this five part project asks students of the Tasmanian region of Australia to explore the history of Port Arthur, a 19th century penal colony located in Tasmania. The project is based on three ideas: (1) studying history can be educational and enjoyable; (2) imagination is an essential part of studying history; and (3) history is most of…

  3. Port Arthur Alive: Exploring Past and Present, 4. Eyewitness.

    ERIC Educational Resources Information Center

    Tasmanian Education Dept., Hobart (Australia).

    This document presents part 4 of a five part project in which students of the Tasmanian region of Australia are invited to explore the history of Port Arthur, a 19th century penal colony located in Tasmania. The project is based on three ideas: (1) studying history can be educational and enjoyable; (2) imagination is an essential part of studying…

  4. Arthur Smith, Local Baptist Pastor.

    ERIC Educational Resources Information Center

    Heaton, Moss, Ed.

    1985-01-01

    Written and published by the students at Gary High School this volume has three articles dealing with East Texas life. The first "Arthur Smith" (David Hancock and others) is an account of growing up in Marian County, Texas is described by the local Baptist minister. The pastor begins with the year of his birth and gives detailed information about…

  5. Create Your Own Amazing Arthur Event.

    ERIC Educational Resources Information Center

    Sharma, Amina

    Since 1996, the "Arthur" program on the Public Broadcasting System (PBS) has featured stories about the challenges of childhood for children ages 3 through 8, illustrating problem-solving and communication skills as well as the importance of self-respect and respect for others. This booklet provides creative ideas for ways to incorporate "Arthur"…

  6. Rhythmical Alchemy: Village Drumming with Arthur Hull.

    ERIC Educational Resources Information Center

    Hillerson, Gary R.; Hull, Arthur

    As a step toward writing a master's thesis in psychology, the connection between rhythm circles and psychotherapeutic process was explored. Arthur Hull, who experienced and preached about the healing power of rhythm for many years, was interviewed. This article recorded the interview between Arthur and the researcher. The interviewer learned that…

  7. Arthur. What Works Clearinghouse Intervention Report

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2006

    2006-01-01

    "Arthur," a book-based educational television program designed for children ages 4-8, is popular among preschool and kindergarten students. The program is based on the storybooks, by Marc Brown, about Arthur, an 8-year-old aardvark. Each show is 30 minutes in length and includes two stories involving characters dealing with moral issues. The show…

  8. Killing and conformal Killing tensors

    NASA Astrophysics Data System (ADS)

    Heil, Konstantin; Moroianu, Andrei; Semmelmann, Uwe

    2016-08-01

    We introduce an appropriate formalism in order to study conformal Killing (symmetric) tensors on Riemannian manifolds. We reprove in a simple way some known results in the field and obtain several new results, like the classification of conformal Killing 2-tensors on Riemannian products of compact manifolds, Weitzenböck formulas leading to non-existence results, and construct various examples of manifolds with conformal Killing tensors.

  9. Killing Coyotes.

    ERIC Educational Resources Information Center

    Beasley, Conger, Jr.

    1993-01-01

    Presents different viewpoints concerning the federal government's Animal Damage Control (ADC) Program cited as responsible for killing millions of predators. Critics provide evidence of outdated and inhumane methods exemplified in the coyote killings. The ADC emphasizes new, nonlethal methods of controlling animals cited as "noxious." (MCO)

  10. Certain Transformations and Symmetry Properties in Gravitational Theories Including Investigations of Conformal and Projective Properties and Killing Tensors.

    NASA Astrophysics Data System (ADS)

    Green, Larry Herschel

    1982-03-01

    This dissertation provides an investigation of certain fundamental invariance and symmetry properties of field theories and their structures at the classical level. Our results provide insight into the physical roles of invariance properties and symmetry demands in the context of various field theoretical models. We stress the role of the conformal and projective properties of the space -time structure. However, more generally, we are concerned with transformations which leave the trace of the Ricci tensor invariant. These objectives are approached by first considering particular types of symmetry conditions that can be characterized by point mappings on a given space-time. After considering the symmetry conditions, invariance properties are examined as free transformations in the context of particular physical models. Symmetry properties which are members of the Family of Contracted Ricci Collineations (FCRC) are considered. Several theorems are given concerning FCRC symmetry properties. While the major part of the investigation is restricted to Einstein's theory, the extension of these results to ECSK theory is discussed. A symmetry property which cannot, in general, be characterized in terms of Lie deformations is the existence of a Killing tensor. The form of all metric tensors which admit Killing tensors with a Segre characteristic {1(111) } which have non-constant eigenvalues is found. The role of conformal invariance in various field theoretical models is examined. Particular attention is given to conformal invariance in theories which have a variable "gravitational constant". While most previous investigations in this area have been restricted to considering symmetric connections, we are chiefly concerned with space -times with a general metric connection. A new type of conformal invariance, which couples conformal transformations on the metric tensor to projective transformations on the torsion tensor and preserves metricity, is discussed. We show that

  11. Killing Range

    PubMed Central

    Asal, Victor; Rethemeyer, R. Karl; Horgan, John

    2015-01-01

    This paper presents an analysis of the Provisional Irish Republican Army's (PIRA) brigade level behavior during the Northern Ireland Conflict (1970-1998) and identifies the organizational factors that impact a brigade's lethality as measured via terrorist attacks. Key independent variables include levels of technical expertise, cadre age, counter-terrorism policies experienced, brigade size, and IED components and delivery methods. We find that technical expertise within a brigade allows for careful IED usage, which significantly minimizes civilian casualties (a specific strategic goal of PIRA) while increasing the ability to kill more high value targets with IEDs. Lethal counter-terrorism events also significantly affect a brigade's likelihood of killing both civilians and high-value targets but in different ways. Killing PIRA members significantly decreases IED fatalities but also significantly decreases the possibility of zero civilian IED-related deaths in a given year. Killing innocent Catholics in a Brigade's county significantly increases total and civilian IED fatalities. Together the results suggest the necessity to analyze dynamic situational variables that impact terrorist group behavior at the sub-unit level. PMID:25838603

  12. Arthur Ashe Jr. Sports Scholars Awards 2010

    ERIC Educational Resources Information Center

    Elfman, Lois; Ford, William J.

    2010-01-01

    "Diverse: Issues In Higher Education" established the Sports Scholars Awards to honor undergraduate students of color who have made achieving both academically and athletically a winning combination. Inspired by tennis legend Arthur Ashe Jr.'s commitment to education as well as his love for the game of tennis, they invite every college and…

  13. Chariots of Fire: King Arthur Revisited.

    ERIC Educational Resources Information Center

    Kramer, Fred

    1987-01-01

    Discusses one of the perennial challenges of teaching English literature--finding ways to relate it to modern problems and issues and thus make the study accessible to students. Includes an example that relates the themes of "Morte D'Arthur" and "Chariots of Fire" and focuses on the sea imagery in both pieces. (JD)

  14. Arthur Ashe Jr. Sports Scholars Awards 2011

    ERIC Educational Resources Information Center

    Elfman, Lois; Walker, Marlon A.

    2011-01-01

    "Diverse: Issues In Higher Education" established the Sports Scholars Awards to honor undergraduate students of color who have made achieving both academically and athletically a winning combination. Inspired by tennis legend Arthur Ashe Jr.'s commitment to education as well as his love for the game of tennis, "Diverse" invites every college and…

  15. Arthur Dunn: Civic Visionary from the Heartland.

    ERIC Educational Resources Information Center

    Nieboer, Ruth A.

    This paper considers the life and accomplishments of Arthur Dunn, a pioneer in the field of social studies education. The paper discusses the cooperative community of Dunn's youth, his education and teaching experiences, and his publications on civics and their influence on teaching methods. (BT)

  16. Convergent Creativity: From Arthur Cropley (1935-) Onwards

    ERIC Educational Resources Information Center

    Tan, Ai-Girl

    2015-01-01

    Arthur Cropley's view on convergent thinking is reviewed, with reflections on the relations of divergent and convergent processes and the roles of knowledge and convergent creativity. While divergence is about considering and generating multiplicity, possibility, difference, originality, and so on; convergence is about relating, associating,…

  17. The Unusual Evolution of Hurricane Arthur 2014

    NASA Technical Reports Server (NTRS)

    Folmer, Michael; Line, William; Cangialosi, John; Halverson, Jeffery; Berndt, Emily; Sienkiewicz, Joseph; Goodman, Steve; Goldberg, Mitch

    2015-01-01

    Hurricane Arthur (2014) was an early season hurricane that had its roots in a convective complex in the Southern Plains of the U.S. As the complex moved into northern Texas, a Mesoscale Convective Vortex (MCV) formed and drifted towards the east of the southern U.S. for a few days before emerging over the southwest Atlantic near South Carolina. The MCV drifted south and slowly acquired tropical characteristics, eventually becoming a Category 2 hurricane that would affect much of eastern North Carolina prior to the 4th of July holiday weekend. Arthur continued up the coast, brushing portions of southeast New England and merged with an upper-level low, completing a full tropical to extratropical-transition in the process, producing damaging wind gusts in portions of the Canadian Maritimes. As part of the GOES-R and JPSS Satellite Proving Grounds, multiple proxy and operational products were available to analyze and forecast this complex evolution. The Storm Prediction Center had products available to monitor the initial severe thunderstorm aspect, while the National Hurricane Center and Ocean Prediction Center were able to monitor the tropical and extratropical transition of Arthur using various convective and red, green, blue (RGB) products that have been introduced in recent years. This paper will discuss Arthur's evolution through the eyes of the various Satellite Proving Ground demonstrations.

  18. Arthur Wright Combs: A Humanistic Pioneer

    ERIC Educational Resources Information Center

    Magnuson, Sandy

    2012-01-01

    Arthur Wright Combs (1912-1999) championed humanistic counseling and education. He proposed a theory that incorporated humanistic values and cognitive factors. This article features a review of his contributions, an overview of his theory, a synthesis of stories about Combs that were acquired during research interviews, and my commentary on his…

  19. 1997 Arthur Ashe Jr. Sport Scholars Awards.

    ERIC Educational Resources Information Center

    Roach, Ronald

    1997-01-01

    Winners of the "Black Issues in Higher Education" Arthur Ashe Jr. 1997 athletes of the year, one male and one female, are profiled and Sport Scholars are listed for baseball, softball, basketball, fencing, archery, football, handball, soccer, field hockey, crew, swimming, gymnastics, tennis, squash, golf, volleyball, lacrosse, wrestling, water…

  20. The MacArthur Fellows Look Back.

    ERIC Educational Resources Information Center

    Cox, June; Daniel, Neil

    1984-01-01

    The article describes replies to a questionnaire by recipients of the MacArthur Fellows Program, an award given to individuals with uncommon abilities across a wide spectrum of creative pursuits. Replies touch on school and family backgrounds, acceleration, importance of grades, recognition of achievement, extracurricular activities, and…

  1. Arthur L. Schmeltekopf Jr. (1932-2007)

    NASA Astrophysics Data System (ADS)

    Howard, Carleton J.

    2009-05-01

    Arthur Louis Schmeltekopf Jr. died of mesothelioma, a lung cancer associated with exposure to asbestos, at his home in Marshall, N. C., on 20 August 2007. He was born on 24 February 1932, in Kyle, Tex., to Arthur L. and Meta (Engelbrecht) Schmeltekopf and grew up nearby on the family farm. Art had an early interest in science. A dispute over the reactivity of alkali metals toward water led to an experiment at Kyle High School involving a chunk of sodium metal and a toilet in the boys' room. The resulting explosion shattered the toilet, creating a flood, multiple geysers and panic in the nearby girls' room, a displaced lid on the school’s septic tank, and an enduring school legend.

  2. Arthur R. Jensen (1923-2012).

    PubMed

    Lubinski, David

    2013-01-01

    Presents an obituary for Arthur R. Jensen. Arthur R. Jensen epitomized the "London School" of psychological thought, studying human individuality as a branch of biology by teaming evolutionary, genetic, and experimental/multivariate/quantitative methods to examine psychological diversity. His intellectual ancestry traces back through his mentor Hans Eysenck to Cyril Burt, Charles Spearman, and, ultimately, Sir Francis Galton. Haggbloom et al. (2002, Review of General Psychology) ranked him among the top 50 eminent psychologists of the 20th century primarily for his work on the construct of general intelligence (g) and its antecedents. But he was also known for his studies in human learning, memory, the cumulative deficit hypothesis, Spearman's hypothesis, the speed of information hypothesis, and test bias. Yet, because of the controversial nature of his work, his career was conspicuously marked by tensions: The extent to which his work was either admired or reviled by many distinguished scientists is unparalleled. PMID:23895609

  3. Arthur Cayley and the `Gruppen Pest'

    NASA Astrophysics Data System (ADS)

    Weinberger, P.

    2015-09-01

    The original contributions of Arthur Cayley to the Philosophical Magazine on group theory and his 'trees' are revisited and to some extend reinterpreted. Both topics were and are of enormous importance not only in physics (group theory, graph theory), but also in quite a few other disciplines as diverse as information technology or, for example, linguistics (trees, graph theory). In order to show that these two topics originally arose from interests in the theory of permutations also Cayley's 'Mousetrap' game is briefly mentioned.

  4. Beyond killing

    PubMed Central

    Vale, Pedro F.; McNally, Luke; Doeschl-Wilson, Andrea; King, Kayla C.; Popat, Roman; Domingo-Sananes, Maria R.; Allen, Judith E.; Soares, Miguel P.; Kümmerli, Rolf

    2016-01-01

    The antibiotic pipeline is running dry and infectious disease remains a major threat to public health. An efficient strategy to stay ahead of rapidly adapting pathogens should include approaches that replace, complement or enhance the effect of both current and novel antimicrobial compounds. In recent years, a number of innovative approaches to manage disease without the aid of traditional antibiotics and without eliminating the pathogens directly have emerged. These include disabling pathogen virulence-factors, increasing host tissue damage control or altering the microbiota to provide colonization resistance, immune resistance or disease tolerance against pathogens. We discuss the therapeutic potential of these approaches and examine their possible consequences for pathogen evolution. To guarantee a longer half-life of these alternatives to directly killing pathogens, and to gain a full understanding of their population-level consequences, we encourage future work to incorporate evolutionary perspectives into the development of these treatments. PMID:27016341

  5. 1. Historic American Buildings Survey Arthur C. Haskell, Photographer April, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Arthur C. Haskell, Photographer April, 1934 (b) LIGHTHOUSE AND KEEPER'S COTTAGE FROM SOUTHWEST - Lighthouse, Cedar Point Scituate Harbor, Scituate, Plymouth County, MA

  6. 11. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1935 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1935 (g) Ext- general view, gateway entrance and fence. - Timothy Jackson House, 527 Washington Street, Newton, Middlesex County, MA

  7. 6. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1935. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1935. (f) Int-General view looking north toward pulpit. - Chestnut Hill Meetinghouse, Chestnut Street, Millville, Worcester County, MA

  8. 10. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1935 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1935 (j) Int- (so- called) Slaves' Pew, East Gallery. - Chestnut Hill Meetinghouse, Chestnut Street, Millville, Worcester County, MA

  9. 5. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1935. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1935. (e) Ext- Detail, main entrance, west front. - Chestnut Hill Meetinghouse, Chestnut Street, Millville, Worcester County, MA

  10. 5. Historic American Buildings Survey, Arthur W. Stewart, Photographer September ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey, Arthur W. Stewart, Photographer September 11, 1936 NORTH ELEVATION OF TYPICAL FIREPLACE. - Henry Crocheron House, 1502 Wilson Street, Bastrop, Bastrop County, TX

  11. Determination of landfill gas composition and pollutant emission rates at fresh kills landfill. Volume 1. Project report. Final report

    SciTech Connect

    1995-12-07

    Air emissions of landfill gas pollutants at Fresh Kills Landfill, located in Staten Island, NY, were estimated based on three weeks of sampling of flow, concentration, and flux at passive vents, gas extraction wells, gas collection plant headers, and the landfill surface conducted by Radian Corporation in 1995. Emission rates were estimated for 202 pollutants, including hydrogen sulfide, mercury vapor, speciated volatile organic compounds, methane, and carbon dioxide. Results indicate that large amounts of mercury enter the methane, and carbon dioxide. Results indicate that large amounts of mercury enter the methane recovery plant. Emission factors based on the results are presented.

  12. Determination of landfill gas composition and pollutant emission rates at fresh kills landfill - project data (for microcomputers). Data file

    SciTech Connect

    1995-12-31

    Air emissions of landfill gas pollutants at Fresh Kills Landfill, located in Staten Island, NY, were estimated based on three weeks of sampling of flow, concentration, and flux at passive vents, gas extraction wells, gas collection plant headers, and the landfill surface conducted by Radian Corporation in 1995. Emission rates were estimated for 202 pollutants, including hydrogen sulfide, mercury vapor, speciated volatile organic compounds, methane, and carbon dioxide. Results indicate that large amounts of mercury enter the methane recovery plant. Emission factors based on the results are presented.

  13. LEGENDS OF KING ARTHUR. LITERATURE CURRICULUM III, STUDENT VERSION.

    ERIC Educational Resources Information Center

    KITZHABER, ALBERT R.

    A STUDENT VERSION OF A CURRICULUM GUIDE ON THE "LEGENDS OF KING ARTHUR" WAS DEVELOPED. SELECTED LEGENDS ARE REPRODUCED ALONG WITH AN INTRODUCTION, STUDY QUESTIONS, AND A PASSAGE FROM MALORY'S "LE MORTE D'ARTHUR" IN THE ORIGINAL LANGUAGE OF THE FIRST EDITION (1485). THE TEACHER VERSION IS ED 010 814. RELATED REPORTS ARE ED 010 129 THROUGH ED 010…

  14. Our Magnetic Planet (Arthur Holmes Medal Lecture)

    NASA Astrophysics Data System (ADS)

    Laj, Carlo

    2015-04-01

    It is a great honour to receive the Arthur Holmes Medal, certainly the highest scientific award of my life. My first thoughts and deep gratitude are with the people who have contributed to me being here today, from my PhD mentors, Pierre Berge and Pierre Pério, later Jacques Labeyrie, my colleagues and students and last, but not least, the members of the Committee on Education of EGU, with whom I have shared over 10 years of a wonderful educational activity. In this presentation, among the various scientific arguments in which I have been involved, I will recall only those mentioned in my letter of nomination to the Holmes Medal, trying to replace them in what was known at the time. After a PhD in Solid State Physics, working in a laboratory of the Commissariat à l'Énergie Atomique, I obtained a post doctoral research position for the the study of liquid binary critical fluids, and worked on this topics for 5 years. I then joined the Centre des Faibles Radioactivités, a CNRS-CEA Institute dedicated to the study of geological-environmental phenomena. My first task there has been to develop a paleomagnetic laboratory, dedicated to the study of Earth Sciences, through the study of the magnetic properties of sediments and igneous rocks. From there on, my entire scientific activity has been devoted to the study of our "Magnetic Planet". My first project in Geophysics dealt with the geodynamical evolution of the Aegean Arc. At the time, only a few paleomagnetic studies existed in the Mediterranean realm, and none in the Aegean region. Moreover all of them dealt with rather old geological formations, so that almost nothing was known about the recent post-cretaceous evolution. The originality of our study was to start from the most recent to the older formations, in order to precisely describe "retro-tectonically" the different phases of rotational deformation. This intensive study (over 700 sampling sites, over 10,000 samples spread over continental Greece, the Aegean

  15. Our Magnetic Planet (Arthur Holmes Medal Lecture)

    NASA Astrophysics Data System (ADS)

    Laj, Carlo

    2015-04-01

    It is a great honour to receive the Arthur Holmes Medal, certainly the highest scientific award of my life. My first thoughts and deep gratitude are with the people who have contributed to me being here today, from my PhD mentors, Pierre Berge and Pierre Pério, later Jacques Labeyrie, my colleagues and students and last, but not least, the members of the Committee on Education of EGU, with whom I have shared over 10 years of a wonderful educational activity. In this presentation, among the various scientific arguments in which I have been involved, I will recall only those mentioned in my letter of nomination to the Holmes Medal, trying to replace them in what was known at the time. After a PhD in Solid State Physics, working in a laboratory of the Commissariat à l'Énergie Atomique, I obtained a post doctoral research position for the the study of liquid binary critical fluids, and worked on this topics for 5 years. I then joined the Centre des Faibles Radioactivités, a CNRS-CEA Institute dedicated to the study of geological-environmental phenomena. My first task there has been to develop a paleomagnetic laboratory, dedicated to the study of Earth Sciences, through the study of the magnetic properties of sediments and igneous rocks. From there on, my entire scientific activity has been devoted to the study of our "Magnetic Planet". My first project in Geophysics dealt with the geodynamical evolution of the Aegean Arc. At the time, only a few paleomagnetic studies existed in the Mediterranean realm, and none in the Aegean region. Moreover all of them dealt with rather old geological formations, so that almost nothing was known about the recent post-cretaceous evolution. The originality of our study was to start from the most recent to the older formations, in order to precisely describe "retro-tectonically" the different phases of rotational deformation. This intensive study (over 700 sampling sites, over 10,000 samples spread over continental Greece, the Aegean

  16. 3. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1935. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1935. From snapshot made by a Survey employee. (c) Ext-Detail entrance on south. - Lucy Gray House, Indian Hill Road, North Tisbury, Dukes County, MA

  17. 1. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1937 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1937 (From snapshot made by Survey Employee.) (a) Ext- General view from Southeast. - Pollard Tavern, Great Road, Bedford, Middlesex County, MA

  18. 1. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1935. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1935. From snapshot made by a Survey employee. (a) Ext- General front view from southeast. - Lucy Gray House, Indian Hill Road, North Tisbury, Dukes County, MA

  19. 2. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1935. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1935. From snapshot made by a Survey employee. (b) Ext- General view rear, looking from north. - Lucy Gray House, Indian Hill Road, North Tisbury, Dukes County, MA

  20. 2. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1937 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1937 (From snapshot made by Survey employee.) (b) Ext- Main building, south end. - Pollard Tavern, Great Road, Bedford, Middlesex County, MA

  1. 9. Historic American Buildings Survey Arthur C. Haskell, Photographer Oct. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Historic American Buildings Survey Arthur C. Haskell, Photographer Oct. 28, 1935 (i) INT.- WALL STENCILLING, REAR ROOM, 2nd. FLOOR - Peter Jayne House, 37 Mugford Street, Marblehead, Essex County, MA

  2. 1. Historic American Buildings Survey Arthur C. Haskell, Photographer (c) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Arthur C. Haskell, Photographer (c) EXT.-MAPLE MEADOW BROOK AQUEDUCT, WILMINGTON, LOOKING NORTHEAST - Middlesex Canal, Maple Meadow Brook Aqueduct, Wilmington, Middlesex County, MA

  3. 12. Historic American Buildings Survey, Arthur C. Haskell, Photographer. August, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Historic American Buildings Survey, Arthur C. Haskell, Photographer. August, 1934. (g) Int- Fireplace and mantel room in back of west stairway, 2nd floor. - Stephen Daniel House, Daniels & Essex Streets, Salem, Essex County, MA

  4. 12. Historic American Buildings Survey, Arthur W. Stewart, Photographer, September ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Historic American Buildings Survey, Arthur W. Stewart, Photographer, September 23, 1936 DETAIL OF TOWER (EAST ELEVATION). - Mission San Jose y San Miguel de Aguayo, Mission Road, San Antonio, Bexar County, TX

  5. 2. Historic American Buildings Survey Arthur C. Haskell, Photographer October, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey Arthur C. Haskell, Photographer October, 1934 (c) GENERAL DETAIL OF LAMP STANDARD, AND PORCH FROM WEST - Iron Standard & Gate, Tremont Place, Boston, Suffolk County, MA

  6. 1. Historic American Buildings Survey Arthur C. Haskell, Photographer October, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Arthur C. Haskell, Photographer October, 1934 (b) LAMP STANDARD, GATE AND RAILING, TREMONT PLACE, FROM NORTHWEST - Iron Standard & Gate, Tremont Place, Boston, Suffolk County, MA

  7. 1. Historic American Buildings Survey, Arthur W. Stewart, Photographer March ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey, Arthur W. Stewart, Photographer March 24, 1936 SOUTHWEST ELEVATION (SOUTH SIDE AND WEST END). - St. Mark's Episcopal Church, 307 East Pecan Street, San Antonio, Bexar County, TX

  8. 4. Historic American Buildings Survey, Arthur W. Stewart, Photographer March ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey, Arthur W. Stewart, Photographer March 24, 1936 DETAIL WEST END AND SOUTH SIDE (SOUTHWEST ELEVATION). - St. Mark's Episcopal Church, 307 East Pecan Street, San Antonio, Bexar County, TX

  9. 3. Historic American Buildings Survey, Arthur W. Stewart, Photographer March ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey, Arthur W. Stewart, Photographer March 16, 1936 EAST ELEVATION (ALTAR END AND BELL TOWER). - St. Mark's Episcopal Church, 307 East Pecan Street, San Antonio, Bexar County, TX

  10. 3. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1935. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1935. (c) Int- Mantel detail (sitting) room SE corner, first floor - Fearing-Warr House, 14 Elm Street, Wareham, Plymouth County, MA

  11. 3. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1935 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1935 (a) Model of Old Windmill and Vats found in Atwood House, W. Chatham, Mass. - Enoch Harding Salt Works, Buck's Creek, West Chatham, Barnstable County, MA

  12. 7. Historic American Buildings Survey, Arthur W. Stewart, Photographer July ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Historic American Buildings Survey, Arthur W. Stewart, Photographer July 15, 1936 DETAIL OF COOKING FIREPLACE IN BASEMENT (LOOKING WEST). - Judge Thomas J. Devine House, San Antonio, Bexar County, TX

  13. 2. Historic American Buildings Survey, Arthur W. Stewart, Photographer April ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey, Arthur W. Stewart, Photographer April 24, 1936 EAST ELEVATION (FRONT). - O'Henry House, Lone Star Brewery, 600 Lone Star Boulevard, San Antonio, Bexar County, TX

  14. 8. Historic American Buildings Survey, Arthur W. Stewart, Photographer June ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Historic American Buildings Survey, Arthur W. Stewart, Photographer June 26, 1936 GENERAL VIEW AFTER 1919 STORM (SOUTHWEST ELEVATION). - Conrad Meuly House & Store, 210 Chaparral Street, Corpus Christi, Nueces County, TX

  15. 7. Historic American Buildings Survey, Arthur W. Stewart, Photographer June ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Historic American Buildings Survey, Arthur W. Stewart, Photographer June 26, 1936 GENERAL VIEW PRIOR TO 1919 STORM (EAST ELEVATION). - Conrad Meuly House & Store, 210 Chaparral Street, Corpus Christi, Nueces County, TX

  16. 12. Historic American Buildings Survey, Arthur C. Haskell, Photographer. August, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Historic American Buildings Survey, Arthur C. Haskell, Photographer. August, 1937. (l) Int- Mantel and Breast S. E. First Floor Room. - Joshua Ward House, 148 Washington Street, Salem, Essex County, MA

  17. 10. Historic American Buildings Survey, Arthur C. Haskell, Photographer. Aug. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Historic American Buildings Survey, Arthur C. Haskell, Photographer. Aug. 1937. (j) Int- Mantel and Breast, N. E. First Floor Room, looking toward front. - Joshua Ward House, 148 Washington Street, Salem, Essex County, MA

  18. 4. Historic American Buildings Survey Arthur C. Haskell, Photographer May ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey Arthur C. Haskell, Photographer May 31, 1936 (ttt) BOSTON STONE, PUBLIC ALLEY No. 102, NEAR MARSHALL ST., BOSTON - Boundary Stones QQQ, RRR, SSS, & TTT, Various Boston locations, Boston, Suffolk County, MA

  19. 16. Historic American Buildings Survey Arthur C. Haskell, Photographer May ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. Historic American Buildings Survey Arthur C. Haskell, Photographer May 29, 1939 (r) INT.- MANTEL & MIRROR, SOUTHEAST ROOM, 1st. FLOOR - Cook-Oliver House, 142 Federal Street, Salem, Essex County, MA

  20. Arthur Miller Wins a Peace Prize: Teaching, Literature, and Therapy.

    ERIC Educational Resources Information Center

    Kopald, Meredith

    1992-01-01

    Describes how a high school student was able to express powerful feelings and achieve some kind of reconciliation with his father through his therapeutic exploration of Arthur Miller's play "Death of a Salesman." (PRA)

  1. 9. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1935. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1935. (k) Int-Detail of Corner Fireplace in Parlor (Living) (SE) Room, First Floor. - Daniel Shute House, Main & South Pleasant Streets, Hingham, Plymouth County, MA

  2. 12. Historic American Buildings Survey Arthur C. Haskell, Photographer Aug. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Historic American Buildings Survey Arthur C. Haskell, Photographer Aug. 3, 1938 (k) INT.- MANTLE, NORTHEAST ROOM, 2nd. FLOOR - Captain William Wildes House, 872 Commercial Street, Weymouth, Norfolk County, MA

  3. 11. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1936 (k) Int- Paneled fireplace end, southeast room, first floor. - Squire William Sever House, 2 Linden Street, Kingston, Plymouth County, MA

  4. 6. Historic American Buildings Survey, Arthur W. Stewart, Photographer, April ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Historic American Buildings Survey, Arthur W. Stewart, Photographer, April 23, 1936 WEST ELEVATION OF CHAPEL (REAR). - Mission San Francisco de la Espada, Berg's Mill Community, San Antonio, Bexar County, TX

  5. 10. Historic American Buildings Survey, Arthur W. Stewart, Photographer, April ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Historic American Buildings Survey, Arthur W. Stewart, Photographer, April 13, 1936 SOUTH ELEVATION OF RECTORY (SIDE). - Mission San Francisco de la Espada, Berg's Mill Community, San Antonio, Bexar County, TX

  6. 7. Historic American Buildings Survey, Arthur W. Stewart, Photographer, April ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Historic American Buildings Survey, Arthur W. Stewart, Photographer, April 13, 1936 DETAIL OF ENTRANCE TO CHAPEL (EAST ELEVATION). - Mission San Francisco de la Espada, Berg's Mill Community, San Antonio, Bexar County, TX

  7. 5. Historic American Buildings Survey, Arthur W. Stewart, Photographer, April ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey, Arthur W. Stewart, Photographer, April 16, 1936 NORTH ELEVATION OF CHAPEL (SIDE). - Mission San Francisco de la Espada, Berg's Mill Community, San Antonio, Bexar County, TX

  8. 2. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1935 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1935 (b) Ext- General view of main house from southeast. - Timothy Jackson House, 527 Washington Street, Newton, Middlesex County, MA

  9. 9. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1935 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1935 (k) Int-Mantel detail, Dining (S.E. Corner) Room, First Floor. - Timothy Jackson House, 527 Washington Street, Newton, Middlesex County, MA

  10. 10. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1935. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1935. (l) Int-Mantel Detail, Bedroom (S.E. Corner) Second Floor. - Timothy Jackson House, 527 Washington Street, Newton, Middlesex County, MA

  11. 3. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1935 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1935 (c) Ext- General view of House and Ell from Southeast. - Timothy Jackson House, 527 Washington Street, Newton, Middlesex County, MA

  12. 16. Historic American Buildings Survey, Arthur W. Stewart, Photographer, September ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. Historic American Buildings Survey, Arthur W. Stewart, Photographer, September 22, 1936 DETAIL OF ROSE WINDOW (SOUTH ELEVATION OF SMALL CHAPEL). - Mission San Jose y San Miguel de Aguayo, Mission Road, San Antonio, Bexar County, TX

  13. 17. Historic American Buildings Survey, Arthur W. Stewart, Photographer, September ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. Historic American Buildings Survey, Arthur W. Stewart, Photographer, September 22, 1936 CLOSE-UP DETAIL OF ROSE WINDOW (SOUTH ELEVATION OF SMALL CHAPEL). - Mission San Jose y San Miguel de Aguayo, Mission Road, San Antonio, Bexar County, TX

  14. "Not the Wise Thought--A Grave for Arthur."

    ERIC Educational Resources Information Center

    Corbett, Linda

    1993-01-01

    Discusses Susan Cooper's series of five books for young adults based on the King Arthur legends. Notes that a reading of modern tellings of that story can lead students to both delight and interest in literary research. (SR)

  15. 4. Photocopy of measured drawing (from Library of Congress) Arthur ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Photocopy of measured drawing (from Library of Congress) Arthur B. Heaton, architect FRONT ELEVATION, DETAILS OF LOWER STORIES, DETAILS OF UPPER STORIES - Wardman Building, K Street Northwest, 1400 Block, Washington, District of Columbia, DC

  16. 8. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1935. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1935. (h) Int-Detail Gallery Stairs, S.E. Corner. - Chestnut Hill Meetinghouse, Chestnut Street, Millville, Worcester County, MA

  17. 9. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1935. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Historic American Buildings Survey, Arthur C. Haskell, Photographer. 1935. (i) Int-Looking down on pulpit and first floor from west gallery. - Chestnut Hill Meetinghouse, Chestnut Street, Millville, Worcester County, MA

  18. 5. Historic American Buildings Survey Arthur C. Haskell, Photographer May ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey Arthur C. Haskell, Photographer May 22, 1936 (e) INT.- SOUTHWEST WALL, EAST ROOM, 1st. FLOOR - Edward Everett House, 16 Harvard Street, Charlestown, Suffolk County, MA

  19. 6. Historic American Buildings Survey Arthur C. Haskell, Photographer Aug. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Historic American Buildings Survey Arthur C. Haskell, Photographer Aug. 4, 1935 (f) INT.- MANTEL, NORTHWEST ROOM, 1st. FLOOR - Colonel John Ashley House, Cooper Road vicinity, Sheffield, Berkshire County, MA

  20. 1. Historic American Buildings Survey, Arthur W. Stewart, Photographer June ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey, Arthur W. Stewart, Photographer June 24, 1936 WEST ELEVATION SHOWING BUILDINGS 1,2 AND 3. - San Bartolo Ranch Buildings, Falcon Reservoir Site, Zapata, Zapata County, TX

  1. 5. Historic American Buildings Survey, Arthur W. Stewart, Photographer June ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey, Arthur W. Stewart, Photographer June 24, 1936 EAST ELEVATION MAIN RANCH HOUSE (REAR). - San Bartolo Ranch Buildings, Falcon Reservoir Site, Zapata, Zapata County, TX

  2. 2. Historic American Buildings Survey, Arthur W. Stewart, Photographer June ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey, Arthur W. Stewart, Photographer June 24, 1936 EAST ELEVATION SHOWING BUILDINGS 3, 2 AND 1. - San Bartolo Ranch Buildings, Falcon Reservoir Site, Zapata, Zapata County, TX

  3. 4. Historic American Buildings Survey, Arthur W. Stewart, Photographer June ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey, Arthur W. Stewart, Photographer June 24, 1936 WEST ELEVATION OF MAIN RANCH HOUSE (FRONT). - San Bartolo Ranch Buildings, Falcon Reservoir Site, Zapata, Zapata County, TX

  4. 3. Historic American Buildings Survey, Arthur C. Haskell, Photographer. April, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey, Arthur C. Haskell, Photographer. April, 1934. (c) Detail of track and set pulleys on quarry incline. - Granite Railway, Pine Hill Quarry to Neponset River, Quincy, Norfolk County, MA

  5. 1. Historic American Buildings Survey, Arthur C. Haskell, Photographer. April, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey, Arthur C. Haskell, Photographer. April, 1934. (a) General view of incline to Quarry from Northwest. - Granite Railway, Pine Hill Quarry to Neponset River, Quincy, Norfolk County, MA

  6. 8. Historic American Buildings Survey, Arthur C. Haskell, Photographer. April, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Historic American Buildings Survey, Arthur C. Haskell, Photographer. April, 1934. (e) Portion of old quarry wagon at head of incline. - Granite Railway, Pine Hill Quarry to Neponset River, Quincy, Norfolk County, MA

  7. 2. Historic American Buildings Survey, Arthur C. Haskell, Photographer. April, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey, Arthur C. Haskell, Photographer. April, 1934. (b) Detail of old railroad part way up incline to quarry. - Granite Railway, Pine Hill Quarry to Neponset River, Quincy, Norfolk County, MA

  8. 7. Historic American Buildings Survey, Arthur C. Haskell, Photographer. April, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Historic American Buildings Survey, Arthur C. Haskell, Photographer. April, 1934. (d) Portion of old machinery now lying beside track. - Granite Railway, Pine Hill Quarry to Neponset River, Quincy, Norfolk County, MA

  9. 8. Historic American Buildings Survey, Arthur W. Stewart, Photographer April ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Historic American Buildings Survey, Arthur W. Stewart, Photographer April 9, 1936 SOUTH WALL OF OLD COURTYARD (LOOKING NORTHEAST). - Mission San Antonio de Valero, Alamo Plaza, San Antonio, Bexar County, TX

  10. 14. Historic American Buildings Survey, Arthur W. Stewart, Photographer April ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. Historic American Buildings Survey, Arthur W. Stewart, Photographer April 9, 1936 SOUTH ELEVATION (LOOKING NORTH IN NEW COURTYARD). - Mission San Antonio de Valero, Alamo Plaza, San Antonio, Bexar County, TX

  11. 11. Historic American Buildings Survey, Arthur W. Stewart, Photographer April ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Historic American Buildings Survey, Arthur W. Stewart, Photographer April 17, 1936 SOUTHEAST ELEVATION (SOUTH SIDE AND EAST REAR). - Mission San Antonio de Valero, Alamo Plaza, San Antonio, Bexar County, TX

  12. 10. Historic American Buildings Survey, Arthur W. Stewart, Photographer April ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Historic American Buildings Survey, Arthur W. Stewart, Photographer April 9, 1936 VIEW INSIDE OLD COURTYARD (LOOKING SOUTHWEST). - Mission San Antonio de Valero, Alamo Plaza, San Antonio, Bexar County, TX

  13. 13. Historic American Buildings Survey, Arthur W. Stewart, Photographer April ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. Historic American Buildings Survey, Arthur W. Stewart, Photographer April 8, 1936 SOUTH ELEVATION (LOOKING NORTH IN NEW COURTYARD). - Mission San Antonio de Valero, Alamo Plaza, San Antonio, Bexar County, TX

  14. 7. Historic American Buildings Survey, Arthur W. Stewart, Photographer April ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Historic American Buildings Survey, Arthur W. Stewart, Photographer April 9, 1936 INSIDE OF OLD COURTYARD (LOOKING WEST). - Mission San Antonio de Valero, Alamo Plaza, San Antonio, Bexar County, TX

  15. 9. Historic American Buildings Survey, Arthur W. Stewart, Photographer September ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Historic American Buildings Survey, Arthur W. Stewart, Photographer September 11, 1936 NORTHEAST ELEVATION OF BARN. - E. Sterling C. Robertson Plantation House, West access road, I-35 vicinity, Salado, Bell County, TX

  16. 3. Historic American Buildings Survey, Arthur W. Stewart, Photographer September ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey, Arthur W. Stewart, Photographer September 11, 1936 NORTH ELEVATION (REAR). - D. H. McFadin House, Farm Road 1331, East of Texas Route 95, Taylor, Williamson County, TX

  17. 1. Historic American Buildings Survey, Arthur W. Stewart, Photographer September ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey, Arthur W. Stewart, Photographer September 11, 1936 SOUTHWEST ELEVATION (SOUTH FRONT AND WEST SIDE). - D. H. McFadin House, Farm Road 1331, East of Texas Route 95, Taylor, Williamson County, TX

  18. 8. Historic American Buildings Survey, Arthur W. Stewart, Photographer September ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Historic American Buildings Survey, Arthur W. Stewart, Photographer September 11, 1936 ELEVATION OF FIREPLACE IN SLAVE QUARTERS. - E. Sterling C. Robertson Plantation House, West access road, I-35 vicinity, Salado, Bell County, TX

  19. 4. Historic American Buildings Survey, Arthur W. Stewart, Photographer September ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey, Arthur W. Stewart, Photographer September 11, 1936 SOUTHWEST ELEVATION. - E. Sterling C. Robertson Plantation House, West access road, I-35 vicinity, Salado, Bell County, TX

  20. 7. Historic American Buildings Survey, Arthur W. Stewart, Photographer September ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Historic American Buildings Survey, Arthur W. Stewart, Photographer September 11, 1936 SOUTHEAST ELEVATION OF SLAVE QUARTERS. - E. Sterling C. Robertson Plantation House, West access road, I-35 vicinity, Salado, Bell County, TX

  1. 10. Historic American Buildings Survey, Arthur W. Stewart, Photographer September ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Historic American Buildings Survey, Arthur W. Stewart, Photographer September 11, 1936 SOUTHEAST ELEVATION OF BARN. - E. Sterling C. Robertson Plantation House, West access road, I-35 vicinity, Salado, Bell County, TX

  2. 3. Historic American Buildings Survey, Arthur W. Stewart, Photographer September ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey, Arthur W. Stewart, Photographer September 11, 1936 NORTH ELEVATION. - E. Sterling C. Robertson Plantation House, West access road, I-35 vicinity, Salado, Bell County, TX

  3. 6. Historic American Buildings Survey, Arthur W. Stewart, Photographer September ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Historic American Buildings Survey, Arthur W. Stewart, Photographer September 11, 1936 ELEVATION OF FIREPLACE IN LIVING ROOM. - E. Sterling C. Robertson Plantation House, West access road, I-35 vicinity, Salado, Bell County, TX

  4. 2. Historic American Buildings Survey, Arthur W. Stewart, Photographer September ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey, Arthur W. Stewart, Photographer September 11, 1936 EAST ELEVATION. - E. Sterling C. Robertson Plantation House, West access road, I-35 vicinity, Salado, Bell County, TX

  5. 1. Historic American Buildings Survey, Arthur W. Stewart, Photographer September ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey, Arthur W. Stewart, Photographer September 11, 1936 SOUTH ELEVATION (FRONT). - E. Sterling C. Robertson Plantation House, West access road, I-35 vicinity, Salado, Bell County, TX

  6. 5. Historic American Buildings Survey, Arthur W. Stewart, Photographer September ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey, Arthur W. Stewart, Photographer September 11, 1936 NORTH ELEVATION OF HALL STAIRWAY. - E. Sterling C. Robertson Plantation House, West access road, I-35 vicinity, Salado, Bell County, TX

  7. 76 FR 16715 - Drawbridge Operation Regulation; Raritan River, Arthur Kill and Their Tributaries, Staten Island...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-25

    ... FR 3316). Public Meeting We do not now plan to hold a public meeting. But you may submit a request... the up and downstream sides of the bridge. (c) Tide constrained deep draft vessels shall notify the... predicted high tide period if a tide constrained deep draft vessel has provided the bridge operator with...

  8. 76 FR 45690 - Drawbridge Operation Regulation; Raritan River, Arthur Kill and Their Tributaries, Staten Island...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-01

    ... tributaries, in the Federal Register (76 FR 16715). We received one comment in response to the proposed rule... the up and downstream sides of the bridge. (c) Tide constrained deep draft vessels shall notify the... predicted high tide period if a tide constrained deep draft vessel has provided the bridge operator with...

  9. 76 FR 52569 - Regulated Navigation Area; Arthur Kill, NY and NJ

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-23

    ... regarding our public dockets in the January 17, 2008, issue of the Federal Register (73 FR 3316). Public... deep draft vessels in the area resulting in a long term disruption to cargo and oil terminal facilities... is available to deep draft commercial vessels. The Coast Guard initially planned to control...

  10. Planning a dynamic kill

    SciTech Connect

    Abel, L.W.

    1996-05-01

    This article discusses the methodology, design philosophy, and guidelines for planning a dynamic-kill operation for a wild well. The topics covered are two methods of computer analysis for designing dynamic-kill requirements, the design process, determining the pumping spread, and the pitfalls that a designer faces in planning a dynamic kill.

  11. Obituary: Arthur Dodd Code (1923-2009)

    NASA Astrophysics Data System (ADS)

    Marché, Jordan D., II

    2009-12-01

    Former AAS president Arthur Dodd Code, age 85, passed away at Meriter Hospital in Madison, Wisconsin on 11 March 2009, from complications involving a long-standing pulmonary condition. Code was born in Brooklyn, New York on 13 August 1923, as the only child of former Canadian businessman Lorne Arthur Code and Jesse (Dodd) Code. An experienced ham radio operator, he entered the University of Chicago in 1940, but then enlisted in the U.S. Navy (1943-45) and was later stationed as an instructor at the Naval Research Laboratory, Washington, D.C. During the war, he gained extensive practical experience with the design and construction of technical equipment that served him well in years ahead. Concurrently, he took physics courses at George Washington University (some under the tutelage of George Gamow). In 1945, he was admitted to the graduate school of the University of Chicago, without having received his formal bachelor's degree. In 1950, he was awarded his Ph.D. for a theoretical study of radiative transfer in O- and B-type stars, directed by Subrahmanyan Chandrasekhar. hired onto the faculty of the Department of Astronomy at the University of Wisconsin-Madison (1951-56). He then accepted a tenured appointment at the California Institute of Technology and the Mount Wilson and Palomar Observatories (1956-58). But following the launch of Sputnik, Code returned to Wisconsin in 1958 as full professor of astronomy, director of the Washburn Observatory, and department chairman so that he could more readily pursue his interest in space astronomy. That same year, he was chosen a member of the Space Science Board of the National Academy of Sciences (created during the International Geophysical Year) and shortly became one of five principal investigators of the original NASA Space Science Working Group. In a cogent 1960 essay, Code argued that astrophysical investigations, when conducted from beyond the Earth's atmosphere, "cannot fail to have a tremendous impact on the

  12. 75 FR 69154 - Land Release for Long Island MacArthur Airport

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-10

    ... Federal Aviation Administration Land Release for Long Island MacArthur Airport AGENCY: Federal Aviation... requesting public comment on the Long Island MacArthur Airport (ISP), Ronkonkoma, New York, notice of...-aeronautical development. The parcel is located on the northeast corner of the Long Island MacArthur...

  13. Obituary: Arthur Dodd Code (1923-2009)

    NASA Astrophysics Data System (ADS)

    Marché, Jordan D., II

    2009-12-01

    Former AAS president Arthur Dodd Code, age 85, passed away at Meriter Hospital in Madison, Wisconsin on 11 March 2009, from complications involving a long-standing pulmonary condition. Code was born in Brooklyn, New York on 13 August 1923, as the only child of former Canadian businessman Lorne Arthur Code and Jesse (Dodd) Code. An experienced ham radio operator, he entered the University of Chicago in 1940, but then enlisted in the U.S. Navy (1943-45) and was later stationed as an instructor at the Naval Research Laboratory, Washington, D.C. During the war, he gained extensive practical experience with the design and construction of technical equipment that served him well in years ahead. Concurrently, he took physics courses at George Washington University (some under the tutelage of George Gamow). In 1945, he was admitted to the graduate school of the University of Chicago, without having received his formal bachelor's degree. In 1950, he was awarded his Ph.D. for a theoretical study of radiative transfer in O- and B-type stars, directed by Subrahmanyan Chandrasekhar. hired onto the faculty of the Department of Astronomy at the University of Wisconsin-Madison (1951-56). He then accepted a tenured appointment at the California Institute of Technology and the Mount Wilson and Palomar Observatories (1956-58). But following the launch of Sputnik, Code returned to Wisconsin in 1958 as full professor of astronomy, director of the Washburn Observatory, and department chairman so that he could more readily pursue his interest in space astronomy. That same year, he was chosen a member of the Space Science Board of the National Academy of Sciences (created during the International Geophysical Year) and shortly became one of five principal investigators of the original NASA Space Science Working Group. In a cogent 1960 essay, Code argued that astrophysical investigations, when conducted from beyond the Earth's atmosphere, "cannot fail to have a tremendous impact on the

  14. Exploring Arthur's Pass Topographic Map and Model Interpretation.

    ERIC Educational Resources Information Center

    Fastier, Murray; Macaulay, John

    1995-01-01

    Provides instructional materials, tasks, and activities to supplement a unit on map reading. Presents a two-page color topographical map of Arthur's Pass (New Zealand). Includes learning activities covering reading grid references, estimating distances, cross-sections, and sketch mapping. Briefly discusses and illustrates digital terrain models.…

  15. 33 CFR 161.70 - Vessel Traffic Service Port Arthur.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Vessel Traffic Service Port... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY VESSEL TRAFFIC MANAGEMENT Vessel Traffic Service and Vessel Movement Reporting System Areas and Reporting Points § 161.70 Vessel Traffic Service Port Arthur. (a)...

  16. Arthur Ashe Jr. Sports Scholars 2009--Male Finalists

    ERIC Educational Resources Information Center

    Diverse: Issues in Higher Education, 2009

    2009-01-01

    This article features the male and female finalists of the Arthur Ashe Jr. Sports Scholars 2009. The male finalists are: (1) Sam Bradford (University of Oklahoma); (2) Jamaal Parker (University of Georgia); (3) Masumi Turnbull (University of Kentucky); and (4) Brian Robiskie (The Ohio State University). The female finalists are: (1) Shardea Croes…

  17. Narrative Development in Bilingual Kindergarteners: Can Arthur Help?

    ERIC Educational Resources Information Center

    Uchikoshi, Yuuko

    2005-01-01

    This study examined the effects of the children's TV program Arthur on the development of narrative skills over an academic year for Spanish-speaking English-language learners. In October, February, and June of their kindergarten year, children were asked to tell a story, in English, prompted by 3 pictures. Before the 2nd and 3rd assessments, half…

  18. American Historian Arthur Schlesinger's Challenge to Women Historians and Scholars.

    ERIC Educational Resources Information Center

    Peterson, Barbara Bennett

    In 1922, Arthur Schlesinger urged his fellow historians to write women into the history books. He recognized that the size and sweep of women's history offered scholars and students the opportunity of a new major field. His call failed to arouse skeptical minds through the 1940s and 1950s as feminism fell into disrepute. But with the resurgence of…

  19. High Tech Training at Arthur Andersen and Co.

    ERIC Educational Resources Information Center

    Dennis, Verl E.

    1984-01-01

    Discusses Arthur Andersen and Company's reasons for using high technology in job training, including its ability to improve productivity, provide training on demand, reduce training costs, and keep educational quality consistent. A Life Cycle Model which is used to integrate high technology into this accounting company's educational programs is…

  20. Astronaut William McArthur prepares for a training exercise

    NASA Technical Reports Server (NTRS)

    1993-01-01

    Wearing training versions of the partial pressure launch and entry garment, Astronaut William S. McArthur prepares to rehearse emergency egress procedures for the STS-58 mission. He is standing outside of the side hatch to the full fuselage trainer.

  1. Reconsidering Arthur Bestor and the Cold War in Social Education.

    ERIC Educational Resources Information Center

    Weltman, Burton

    2000-01-01

    Explores the development of Arthur Bestor's ideas and his differences with progressives during the 1950's. Contends their differences, exacerbated by the Cold War, were matters of emphasis not principles. Concludes that ongoing post-Cold War battles among liberal social educators should be resolved in favor of their common social and educational…

  2. Neuro syphilis: Portrayals by Sir Arthur Conan Doyle

    PubMed Central

    Somasundaram, O.

    2009-01-01

    The developments in neuro syphilis in the 19th century are integral parts of the history of psychiatry. The delineation of various aspects of neuro syphilis by Sir Arthur Conan Doyle in three of his stories is discussed in brief. PMID:19881059

  3. Ion-kill dosimetry

    NASA Technical Reports Server (NTRS)

    Katz, R.; Cucinotta, F. A.; Fromm, M.; Chambaudet, A.

    2001-01-01

    Unanticipated late effects in neutron and heavy ion therapy, not attributable to overdose, imply a qualitative difference between low and high LET therapy. We identify that difference as 'ion kill', associated with the spectrum of z/beta in the radiation field, whose measurement we label 'ion-kill dosimetry'.

  4. Cloning, killing, and identity.

    PubMed Central

    McMahan, J

    1999-01-01

    One potentially valuable use of cloning is to provide a source of tissues or organs for transplantation. The most important objection to this use of cloning is that a human clone would be the sort of entity that it would be seriously wrong to kill. I argue that entities of the sort that you and I essentially are do not begin to exist until around the seventh month of fetal gestation. Therefore to kill a clone prior to that would not be to kill someone like you or me but would be only to prevent one of us from existing. And even after one of us begins to exist, the objections to killing it remain comparatively weak until its psychological capacities reach a certain level of maturation. These claims support the permissibility of killing a clone during the early stages of its development in order to use its organs for transplantation. PMID:10226909

  5. Evolution of coalitionary killing.

    PubMed

    Wrangham, R W

    1999-01-01

    Warfare has traditionally been considered unique to humans. It has, therefore, often been explained as deriving from features that are unique to humans, such as the possession of weapons or the adoption of a patriarchal ideology. Mounting evidence suggests, however, that coalitional killing of adults in neighboring groups also occurs regularly in other species, including wolves and chimpanzees. This implies that selection can favor components of intergroup aggression important to human warfare, including lethal raiding. Here I present the principal adaptive hypothesis for explaining the species distribution of intergroup coalitional killing. This is the "imbalance-of-power hypothesis," which suggests that coalitional killing is the expression of a drive for dominance over neighbors. Two conditions are proposed to be both necessary and sufficient to account for coalitional killing of neighbors: (1) a state of intergroup hostility; (2) sufficient imbalances of power between parties that one party can attack the other with impunity. Under these conditions, it is suggested, selection favors the tendency to hunt and kill rivals when the costs are sufficiently low. The imbalance-of-power hypothesis has been criticized on a variety of empirical and theoretical grounds which are discussed. To be further tested, studies of the proximate determinants of aggression are needed. However, current evidence supports the hypothesis that selection has favored a hunt-and-kill propensity in chimpanzees and humans, and that coalitional killing has a long history in the evolution of both species. PMID:10601982

  6. How neutrophils kill fungi.

    PubMed

    Gazendam, Roel P; van de Geer, Annemarie; Roos, Dirk; van den Berg, Timo K; Kuijpers, Taco W

    2016-09-01

    Neutrophils play a critical role in the prevention of invasive fungal infections. Whereas mouse studies have demonstrated the role of various neutrophil pathogen recognition receptors (PRRs), signal transduction pathways, and cytotoxicity in the murine antifungal immune response, much less is known about the killing of fungi by human neutrophils. Recently, novel primary immunodeficiencies have been identified in patients with a susceptibility to fungal infections. These human 'knock-out' neutrophils expand our knowledge to understand the role of PRRs and signaling in human fungal killing. From the studies with these patients it is becoming clear that neutrophils employ fundamentally distinct mechanisms to kill Candida albicans or Aspergillus fumigatus. PMID:27558342

  7. FISH KILLS, NORTH CAROLINA

    EPA Science Inventory

    Data related to fish kills in North Carolina are collected and stored in tables on the Web at the North Carolina Department of Environment and Natural Resources. http://www.esb.enr.state.nc.us/Fishkill/fishkill00.htm

  8. 9. VIEW SHOWING PEARL WHITFORD (LEFT) AND ARTHUR RAINING BIRD ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. VIEW SHOWING PEARL WHITFORD (LEFT) AND ARTHUR RAINING BIRD (RIGHT) HOLDING A FRAMED FLOUR SACK USED BY THE ROCKY BOY'S AGENCY FLOUR MILL. THE SACK SHOWS AN IMAGE OF ROCK BOY, LEADER OF THE CHIPPEWA AND CREE INDIANS IN MONTANA AT THE TIME ROCK BOY'S RESERVATION WAS CREATED BY CONGRESS (PHOTO WAS TAKEN BEHIND THE AGENCY'S SCHOOL). - Rocky Boy's Agency Flour Mill, Rocky Boy, Hill County, MT

  9. A Rosenzweig-MacArthur (1963) Criterion for the Chemostat

    PubMed Central

    Cheng, Yuanji

    2016-01-01

    The Rosenzweig-MacArthur (1963) criterion is a graphical criterion that has been widely used for elucidating the local stability properties of the Gause (1934) type predator-prey systems. It has not been stated whether a similar criterion holds for models with explicit resource dynamics (Kooi et al. (1998)), like the chemostat model. In this paper we use the implicit function theorem and implicit derivatives for proving that a similar graphical criterion holds under chemostat conditions, too. PMID:27517080

  10. Cataract surgery without anaesthesia: two descriptions by Arthur Jacob.

    PubMed

    Haridas, R P

    2009-07-01

    Dr Arthur Jacob (1790-1874), of Dublin, Ireland, was one of the leading ophthalmologists of his time. He was the first to describe the membrane that contains the rods and cones in the eye (membrana Jacobi) and basal cell carcinoma (Jacob's ulcer). He made a curved needle for cataract surgery from a sewing needle (Jacob's needle). Two descriptions of cataract surgery without anaesthesia are presented. PMID:19705632

  11. 4. Historic American Buildings Survey, Arthur W. LeBoeuf, Photographer, 1937 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey, Arthur W. LeBoeuf, Photographer, 1937 DETAIL OF WINDOW BREAKING INTO PEDIMENT. - First Congregational Church, 301 Benefit Street, Providence, Providence County, RI

  12. Determination of landfill gas composition and pollutant emission rates at fresh kills landfill. Volume 2. Appendices to project report. Final report

    SciTech Connect

    1995-12-07

    Air emissions of landfill gas pollutants at Fresh Kills Landfill, located in Staten Island, NY, were estimated based on three weeks of sampling of flow, concentration, and flux at passive vents, gas extraction wells, gas collection plant headers, and the landfill surface conducted by Radian Corporation in 1995. Emission rates were estimated for 202 pollutants, including hydrogen sulfide, mercury vapor, speciated volatile organic compounds, methane, and carbon dioxide. Results indicate that large amounts of mercury enter the methane, and carbon dioxide. Results indicate that large amounts of mercury enter the methane recovery plant. Emission factors based on the results are presented.

  13. Children Who Kill.

    ERIC Educational Resources Information Center

    Natale, Jo Anna

    1999-01-01

    Two recent books, "When Good Kids Kill," by Michael D. Kelleher, and "Lost Boys," by James Garbarino, explore how children become killers and suggest ways to reduce our high-pressure society's epidemic levels of youth violence. Physically or psychologically distant parents and unaffirmative media messages are negative influences. (MLH)

  14. Killing vectors and anisotropy

    SciTech Connect

    Krisch, J. P.; Glass, E. N.

    2009-08-15

    We consider an action that can generate fluids with three unequal stresses for metrics with a spacelike Killing vector. The parameters in the action are directly related to the stress anisotropies. The field equations following from the action are applied to an anisotropic cosmological expansion and an extension of the Gott-Hiscock cosmic string.

  15. Symposium 1: The Arthur case--a proposal for legislation.

    PubMed

    Brahams, D; Brahams, M

    1983-03-01

    Following the acquittal of Dr Leonard Arthur in the case of the Down's syndrome infant the co-authors of the first paper in this symposium prepared a draft bill on the treatment of chronically disabled infants which has since been informally commended by the Director of Public Prosecutions. A second contributor, a law student, also argues for legislation as being the most effective way for society to have its standards clarified and observed. In a final paper Dr Havard, Secretary of the British Medical Association, opposes legislation believing it would raise far more problems than it would resolve. The first article was originally published in the Law Society's Gazette. PMID:6220153

  16. Sir Arthur Conan Doyle: the author was an ophthalmologist.

    PubMed

    Ravin, J G; Migdal, C

    1995-01-01

    Sir Arthur Conan Doyle created the famous detective Sherlock Holmes, and his faithful companion, Dr. Watson. A graduate of the University of Edinburgh Medical School, Doyle (1859-1930) spent nearly ten years practicing medicine. During his years in general practice, Doyle gave particular attention to the eye. Later, he studied ophthalmology in Vienna and spent time with the best known ophthalmologist in Paris. He returned to London and established an ophthalmological office near Harley Street. His literary career soon overtook the medical career, but he made many references to medicine, and to ophthalmology in particular in his writings. PMID:8599161

  17. Begin at the Beginning: Reflections on the Career of Arthur Cropley

    ERIC Educational Resources Information Center

    Maslany, George

    2015-01-01

    Arthur Cropley's academic career began in the early 1960s and, more than 50 years later, shows few signs of abating. Over this lengthy period, he has made important contributions not only to creativity research, but to a range of related areas of psychology. Arthur Cropley has also been an influential figure in the careers of several generations…

  18. It's Elementary: Engaging Students through the Writings of Arthur Conan Doyle.

    ERIC Educational Resources Information Center

    Morrissey, Ted

    2002-01-01

    Notes that Sir Arthur Conan Doyle's writing allows for a variety of critical thinking activities, extensive use of computer technology, and the involvement of the entire faculty, staff and administration in the learning process. Presents a few activities that teachers can do with their students based on the work of Arthur Conan Doyle. (SG)

  19. Truman's Firing of General Douglas MacArthur during the Korean War.

    ERIC Educational Resources Information Center

    Patterson, Amy; Schamel, Wynell; Potter Lee Ann

    2000-01-01

    Provides background information on the events that led up to President Harry S. Truman firing General Douglas MacArthur during the Korean War. Includes a copy of the document dismissing MacArthur from his position. Includes teaching activities corresponding to this event in history. (CMK)

  20. Astronaut William S. McArthur in training for contingency EVA in WETF

    NASA Technical Reports Server (NTRS)

    1993-01-01

    Astronaut William S. McArthur, mission specialist, participates in training for contingency extravehicular activity (EVA) for the STS-58 mission. He is wearing the extravehicular mobility unit (EMU) minus his helmet. For simulation purposes, McArthur was about to be submerged to a point of neutral buoyancy in the JSC Weightless Environment Training Facility (WETF).

  1. How microglia kill neurons.

    PubMed

    Brown, Guy C; Vilalta, Anna

    2015-12-01

    Microglia are resident brain macrophages that become inflammatory activated in most brain pathologies. Microglia normally protect neurons, but may accidentally kill neurons when attempting to limit infections or damage, and this may be more common with degenerative disease as there was no significant selection pressure on the aged brain in the past. A number of mechanisms by which activated microglia kill neurons have been identified, including: (i) stimulation of the phagocyte NADPH oxidase (PHOX) to produce superoxide and derivative oxidants, (ii) expression of inducible nitric oxide synthase (iNOS) producing NO and derivative oxidants, (iii) release of glutamate and glutaminase, (iv) release of TNFα, (v) release of cathepsin B, (vi) phagocytosis of stressed neurons, and (vii) decreased release of nutritive BDNF and IGF-1. PHOX stimulation contributes to microglial activation, but is not directly neurotoxic unless NO is present. NO is normally neuroprotective, but can react with superoxide to produce neurotoxic peroxynitrite, or in the presence of hypoxia inhibit mitochondrial respiration. Glutamate can be released by glia or neurons, but is neurotoxic only if the neurons are depolarised, for example as a result of mitochondrial inhibition. TNFα is normally neuroprotective, but can become toxic if caspase-8 or NF-κB activation are inhibited. If the above mechanisms do not kill neurons, they may still stress the neurons sufficiently to make them susceptible to phagocytosis by activated microglia. We review here whether microglial killing of neurons is an artefact, makes evolutionary sense or contributes in common neuropathologies and by what mechanisms. This article is part of a Special Issue entitled SI: Neuroprotection. PMID:26341532

  2. Factors Affecting Zebra Mussel Kill by the Bacterium Pseudomonas fluorescens

    SciTech Connect

    Daniel P. Molloy

    2004-02-24

    The specific purpose of this research project was to identify factors that affect zebra mussel kill by the bacterium Pseudomonas fluorescens. Test results obtained during this three-year project identified the following key variables as affecting mussel kill: treatment concentration, treatment duration, mussel siphoning activity, dissolved oxygen concentration, water temperature, and naturally suspended particle load. Using this latter information, the project culminated in a series of pipe tests which achieved high mussel kill inside power plants under once-through conditions using service water in artificial pipes.

  3. Charged conformal Killing spinors

    SciTech Connect

    Lischewski, Andree

    2015-01-15

    We study the twistor equation on pseudo-Riemannian Spin{sup c}-manifolds whose solutions we call charged conformal Killing spinors (CCKSs). We derive several integrability conditions for the existence of CCKS and study their relations to spinor bilinears. A construction principle for Lorentzian manifolds admitting CCKS with nontrivial charge starting from CR-geometry is presented. We obtain a partial classification result in the Lorentzian case under the additional assumption that the associated Dirac current is normal conformal and complete the classification of manifolds admitting CCKS in all dimensions and signatures ≤5 which has recently been initiated in the study of supersymmetric field theories on curved space.

  4. [Pioneers of anaesthesiology--Arthur Ernest Guedel (1883-1956)].

    PubMed

    Podwińska, Ewa; Jośko, Jadwiga; Kucewicz-Czech, Ewa; Misiołek, Hanna; Klimasara, Jan; Szozda, Marcin

    2008-01-01

    Arthur Ernest Guedel was a US born anaesthetist, whose name found its place among key persons in our specialty. Commonly known as a developer of the oropharyngeal airway, he did much more. Possibly, his major achievements were the detailed description of nitrous oxide and diethyl ether anaesthesia. He was among the firstfull-time US anaesthesiologists, and also served in his profession during the First World War. So called Guedel charts, describing the relationship between the level of anaesthesia and pupillary reactions, allowed many non-anaesthesiologists to administer diethyl ether relatively safely. Together with Waters, he was among pioneers of cuffed endotracheal tubes. At the end of his career, in 1937, he produced a manual "Inhalational Anaesthesia--A Fundamental Guide, which served at least three generations of medical professionals. PMID:19469123

  5. Kill operation requires thorough analysis

    SciTech Connect

    Abel, L.W.

    1995-05-15

    Full control of a blowout well requires a properly designed post-capping kill operation because failures in regaining well control usually occur during the kill operation, not during capping. Capping (the installation of pressure control or diverter equipment on the wellhead) is generally very reliable in gaining control of a blowout well. The following techniques are some of the viable means of killing blowout wells once the capping assemblies are in place: direct shut in of the flow; bullheading; momentum kill; volumetric control for migration of fluids or lubrication after migration ceases; and dynamic kills (friction-based dynamic kills or mass flow rate kills) The objective of most post-capping operations is to stop the flow and put the well under hydrostatic control. The means of killing a blowout once capping assemblies are in place should be chosen with care to avoid problems such as cratering, equipment failure, and underground blowouts. The particular circumstances and well integrity will dictate which kill method will be the most viable. Each of these five methods are explained.

  6. 1. Historic American Buildings Survey, Arthur W. LeBoeuf, Photographer, 1937 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey, Arthur W. LeBoeuf, Photographer, 1937 DETAIL OF MANTEL. - John Mason House (Mantel), Weybosset Street (moved to Rhode Island School of Design), Providence, Providence County, RI

  7. Astronaut William McArthur talks to students on earth using SAREX

    NASA Technical Reports Server (NTRS)

    1993-01-01

    From the flight deck of the Earth-orbiting Space Shuttle Columbia, astronaut William S. McArthur talks to students on Earth. The mission specialist's activity was part of the Shuttle Amateur Radio Experiment (SAREX) which serves to enlighten students around the world on the topic of space travel. McArthur (call letters KC5ACR) is one of three licensed amateur radio operators on the seven-member flight.

  8. How electroshock weapons kill!

    NASA Astrophysics Data System (ADS)

    Lundquist, Marjorie

    2010-03-01

    Growing numbers of law enforcement officers now carry an electroshock weapon (ESW). Over 500 U.S. deaths have followed ESW use in the past 26 years; over 450 of these deaths followed use of an electromuscular disruptor in the past 9 years. Most training courses teach that ESWs are safe; that they can kill only by the direct effect of electric current on the heart; and that a death following use of an ESW always has some other cause. All these teachings are false! The last was disproved by Lundquist.^1 Williams^2 ruled out direct electrical effects as a cause of almost all the 213 deaths he studied, leaving disruption of normal physiological processes as the only alternative explanation. Careful study of all such deaths identifies 4 different ways that death has or could have been brought about by the ESW: kidney failure following rhabdomyolysis [rare]; cardiac arrest from hyperkalemia following rhabdomyolysis [undocumented]; lactic acid-induced ventricular fibrillation [conclusive proof impossible]; and [most common] anoxia from so much lactic acid in the circulating blood that it acts as an oxygen scavenger, continuously depleting the blood of oxygen until most of the lactate has been metabolized. ^1M. Lundquist, BAPS 54(1) K1.270(2009). ^2Howard E. Williams, Taser Electronic Control Devices and Sudden In-Custody Death, 2008.

  9. Flood geomorphology of Arthurs Rock Gulch, Colorado: paleoflood history

    USGS Publications Warehouse

    Waythomas, C.F.; Jarrett, R.D.

    1994-01-01

    Episodic late Quaternary flooding is recorded by bouldery deposits and slackwater sediments along Arthurs Rock Gulch, an ephemeral stream west of Fort Collins, Colorado. Flood deposits consist of individual granodiorite and pegmatite boulders, boulder bars, and coarse overbank sediment that rest on erosional terrace segments along the channel. We identified evidence for at least five flood in the lower two thirds of the 1.84 km2 drainage basin. Flood deposits are differentiated by their position above the active channel, weathering characteristics, degree of boulder burial by colluvium, amount of lichen cover, and position with respect to terrace and colluvial deposits. Age estimates for the flood deposits are based on radiocarbon dating, tree-ring analyses, and relative-age criteria from four sites in the basin. At least two floods occurred in the last 300 years; a third flood is at least 5000 years old, but likely younger than 10,000 yr BP; and the two oldest floods occurred at least 40,000 years BP. ?? 1994.

  10. [Sir Arthur Conan Doyle, Sherlock Holmes and infectious diseases].

    PubMed

    Ledermann D, Walter

    2010-10-01

    Besides a pleasant author of best sellers, Sir Arthur Conan Doyle was a medical doctor, writing excellent short stories about the exercise of his profession in England. However, even he mentions The British Medical Journal and The Lancet in the Sherlock Holmes's stories, when in the plot introduces infectious diseases, Conan Doyle ignores important discoveries in the field of tetanus. Anyway, the appearing of infectious diseases in the adventures of the detective are rare: one mention of tetanus, another of leprosy and- the most analyzed in medical literature a case of murder by inoculation of bacteria, probably the agent of melioidosis. Also he makes his hero discovers the toxic actions of a medusa and a transplant of solid organ. Little for a physician and less for an author who also wrote science fiction: it seems that the history of the great medical discoveries at the end of nineteenth century and beginning of the twentieth has passed by his side.., and he just couldn't see it. PMID:21186510

  11. Notes on super Killing tensors

    NASA Astrophysics Data System (ADS)

    Howe, P. S.; Lindström, U.

    2016-03-01

    The notion of a Killing tensor is generalised to a superspace setting. Conserved quantities associated with these are defined for superparticles and Poisson brackets are used to define a supersymmetric version of the even Schouten-Nijenhuis bracket. Superconformal Killing tensors in flat superspaces are studied for spacetime dimensions 3,4,5,6 and 10. These tensors are also presented in analytic superspaces and super-twistor spaces for 3,4 and 6 dimensions. Algebraic structures associated with superconformal Killing tensors are also briefly discussed.

  12. Groundwater Flow in the Arthur Marble Aquifer, New Zealand

    NASA Astrophysics Data System (ADS)

    Stewart, M. K.

    2008-05-01

    Arthur Marble underlies the Takaka Valley and outcrops in Karst Uplands to east and west of the valley in the South Island of New Zealand. It is the principal groundwater aquifer in the region and host to the remarkable Waikoropupu Springs near the coast. With average flow of 13,300 L/s, the karstic springs have many interesting features including unusual size and clarity. This work uses rainfall and river level, natural tracer and chemical measurements to determine the recharge sources and nature of the flow system in the Arthur Marble Aquifer (AMA). Total recharge to the AMA of 19,750 L/s comes from three sources (Karst Uplands stream seepage, Takaka River seepage and Takaka Valley rainfall infiltration). Since 13,300 L/s is discharged at the springs, the remainder must escape via offshore springs (6,450 L/s). The oxygen-18 mass balance allows the contribution of each source to each spring to be determined; most of the flow to the Main Spring of the Waikoropupu Springs comes from the Karst Uplands. The offshore springs are mostly fed from the Takaka River. The chemical concentrations of the Main Spring show input of 0.5% of sea water on average, but varying with flow. This variation with flow shows that two water components (sea-water-bearing and non-sea-water-bearing) contribute to the spring's discharge. Tritium measurements spanning 40 years, and CFC-11 measurements, give a mean residence time of 8 years for the Main Spring water using the preferred two-component model. Our conceptual flow model, based on the flow, oxygen-18, chloride and tritium measurements, reveals that two different flow systems with different recharge sources are needed to explain the flow within the AMA. One system contains deeply penetrating old water with mean age 10.2 years and water volume 3 cubic kilometers, recharged from the Karst Uplands. The other, at shallow levels below the valley floor, has much younger water, with mean age 1.2 years and water volume 0.4 cubic kilometers

  13. Formation fracturing kills Indonesian blowout

    SciTech Connect

    Wizyodiazjo, S.; Salech, M.; Sumanta, K.

    1982-11-15

    Dynamic killing methods without fracturing could not be applied in killing PT-29 blowout, due to the reservoir rock properties (shaley sand formation). A special fracturing and acidizing technique was required in order to allow the calculated kill rate of 40 bbl/ min. A low injection rate of 0.5 bbl/min with high injection pressure of 1,250 psi occurred due to a degree of formation damage and the mud cake covering the sand face. The calculated formation fracture pressure of 1,393 psi was a reliable value compared to actual fracture pressure of 1,400 psi. The designed killing rate of 40 bbl/ min could not reach the blowout well due to some leak-off of the injected fluid in unexpected directions of the induced fractures. Clearing PT-29 of all debris was very important for immediate well capping. The capping operation was done after the fire was extinguished; although the well was still flowing gas and water, no hazard of explosion was detected. The exact subsurface position of the blowout well of PT-29 was uncertain due to the lack of directional survey data. This problem reduced the effectiveness of the killing operation. A reliable water supply is important to the success of the killing job. Once the fracture had been induced, kill fluid had to be pumped continuously; any interruption might cause the fracture to heal. Deviation and directional survey data on every vertical or directional well are absolutely important for accurate relief well drilling purposes in case it is required.

  14. Killing, letting die and euthanasia.

    PubMed

    Husak, D N

    1979-12-01

    Medical ethicists debate whether or not the moral assessment of cases of euthanasia should depend on whether the patient is 'killed' or 'allowed to die'. The usual presupposition is that a clear distinction between killing and letting die can be drawn so that this substantive question is not begged. I contend that the categorisation of cases of instances of killing rather than as instances of letting die depends in part on a prior moral assessment of the case. Hence is it trivially rather than substantively true that the distinction has moral significance. But even if a morally neutral (ie non-question begging) distinction could be drawn, its application to the euthanasia controversy is problematic. I illustrate the difficulties of employing this distinction to reach moral conclusions by critically discussing Philippa Foot's recent treatment of euthanasia. I conclude that even if an act of euthanasia is an instance of killing, and there exists a prima facie moral duty not to kill, and no more stringent duty overrides this duty, one still cannot determine such an act to be morally impermissible. PMID:541821

  15. Public health assessment for State Marine of Port Arthur, Port Arthur, Jefferson County, Texas, Region 6, CERCLIS number TXD099801102. Final report

    SciTech Connect

    1999-07-30

    The State Marine of Port Arthur National Priorities List site, is a 17,197-acre former barge cleaning facility on a small peninsula in the northeastern part of Port Arthur, Jefferson County, Texas. The facility operated from 1974 until 1988. Barge cleaning operations at the site have resulted in the contamination of surface soil and sediment with polycyclic aromatic hydrocarbons and metals. The Agency for Toxic Substances and Disease Registry (ATSDR) reviewed available environmental information for the site and evaluated several potential exposure situations. These exposure situations include potential contact with site contaminants in surface water, sediment, surface soil, and groundwater. Although site-related contaminants have been found in several of these media, currently the contaminants on or off the site do not pose a public health threat. Based on available information, the authors have concluded that, overall, the State Marine site poses an indeterminate public health hazard.

  16. Selective Killing of Nonreplicating Mycobacteria

    PubMed Central

    Bryk, Ruslana; Gold, Benjamin; Venugopal, Aditya; Singh, Jasbir; Samy, Raghu; Pupek, Krzysztof; Cao, Hua; Popescu, Carmen; Gurney, Mark; Hotha, Srinivas; Cherian, Joseph; Rhee, Kyu; Ly, Lan; Converse, Paul J.; Ehrt, Sabine; Vandal, Omar; Jiang, Xiuju; Schneider, Jean; Lin, Gang; Nathan, Carl

    2008-01-01

    SUMMARY Antibiotics are typically more effective against replicating rather than nonreplicating bacteria. However, a major need in global health is to eradicate persistent or nonreplicating subpopulations of bacteria such as Mycobacterium tuberculosis (Mtb). Hence, identifying chemical inhibitors that selectively kill bacteria that are not replicating is of practical importance. To address this, we screened for inhibitors of dihydrolipoamide acyltransferase (DlaT), an enzyme required by Mtb to cause tuberculosis in guinea pigs and used by the bacterium to resist nitric oxide-derived reactive nitrogen intermediates, a stress encountered in the host. Chemical screening for inhibitors of Mtb DlaT identified select rhodanines as compounds that almost exclusively kill nonreplicating mycobacteria in synergy with products of host immunity, such as nitric oxide and hypoxia, and are effective on bacteria within macrophages, a cellular reservoir for latent Mtb. Compounds that kill nonreplicating pathogens in cooperation with host immunity could complement the conventional chemotherapy of infectious disease. PMID:18329613

  17. Killing symmetries as Hamiltonian constraints

    NASA Astrophysics Data System (ADS)

    Lusanna, Luca

    2016-02-01

    The existence of a Killing symmetry in a gauge theory is equivalent to the addition of extra Hamiltonian constraints in its phase space formulation, which imply restrictions both on the Dirac observables (the gauge invariant physical degrees of freedom) and on the gauge freedom. When there is a time-like Killing vector field only pure gauge electromagnetic fields survive in Maxwell theory in Minkowski space-time, while in ADM canonical gravity in asymptotically Minkowskian space-times only inertial effects without gravitational waves survive.

  18. 33 CFR 117.801 - Newtown Creek, Dutch Kills, English Kills and their tributaries.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., English Kills and their tributaries. 117.801 Section 117.801 Navigation and Navigable Waters COAST GUARD....801 Newtown Creek, Dutch Kills, English Kills and their tributaries. (a) The following requirements apply to all bridges across Newtown Creek, Dutch Kills, English Kills, and their tributaries: (1)...

  19. 33 CFR 117.801 - Newtown Creek, Dutch Kills, English Kills and their tributaries.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., English Kills and their tributaries. 117.801 Section 117.801 Navigation and Navigable Waters COAST GUARD....801 Newtown Creek, Dutch Kills, English Kills and their tributaries. (a) The following requirements apply to all bridges across Newtown Creek, Dutch Kills, English Kills, and their tributaries: (1)...

  20. 33 CFR 117.801 - Newtown Creek, Dutch Kills, English Kills and their tributaries.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., English Kills and their tributaries. 117.801 Section 117.801 Navigation and Navigable Waters COAST GUARD....801 Newtown Creek, Dutch Kills, English Kills and their tributaries. (a) The following requirements apply to all bridges across Newtown Creek, Dutch Kills, English Kills, and their tributaries: (1)...

  1. 33 CFR 117.801 - Newtown Creek, Dutch Kills, English Kills and their tributaries.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., English Kills and their tributaries. 117.801 Section 117.801 Navigation and Navigable Waters COAST GUARD....801 Newtown Creek, Dutch Kills, English Kills and their tributaries. (a) The following requirements apply to all bridges across Newtown Creek, Dutch Kills, English Kills, and their tributaries: (1)...

  2. 33 CFR 117.801 - Newtown Creek, Dutch Kills, English Kills and their tributaries.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., English Kills and their tributaries. 117.801 Section 117.801 Navigation and Navigable Waters COAST GUARD....801 Newtown Creek, Dutch Kills, English Kills and their tributaries. (a) The following requirements apply to all bridges across Newtown Creek, Dutch Kills, English Kills, and their tributaries: (1)...

  3. Farm Education at Stony Kill.

    ERIC Educational Resources Information Center

    Parisio, Richard

    1986-01-01

    Describes typical winter farm lessons for students visiting Stony Kill Farm Environmental Education Center located 70 miles north of New York City: butter and corncake making, soil erosion experiments, dissecting and growing seeds. Emphasizes major theme of conservation of farmland from destructive farming practices and careless development. (NEC)

  4. Does Assessment Kill Student Creativity?

    ERIC Educational Resources Information Center

    Beghetto, Ronald A.

    2005-01-01

    Does assessment kill creativity? In this article, creativity is defined and discussed and an overview of creativity and motivational research is provided to describe how assessment practices can influence students' creativity. Recommendations for protecting creativity when assessing students also are provided.

  5. South Lake Arthur field and occurrence of buried structures along Oligocene trend of southwestern Louisiana

    SciTech Connect

    Prescott, M.P.

    1988-09-01

    Significant gas reserves have recently been discovered in the Miogypsinoides sands along the Oligocene trend at the South Lake Arthur field. Detailed subsurface maps and seismic data are presented to exhibit the extent and nature of this local structure and to demonstrate future opportunities along the Oligocene trend.

  6. Connecting Communities, Schools, and Families: An Interview with Arthur (Andy) Horne, Phd

    ERIC Educational Resources Information Center

    Ziomek-Daigle, Jolie

    2007-01-01

    Dr. Arthur (Andy) Horne completed his PhD at Southern Illinois University in 1971. He taught at Indiana State University from 1971 until 1989, during which time he served as a member of the faculty and the director of training of the APA-accredited Counseling Psychology Program. He also was a member of the AAMFT-accredited Marriage and Family…

  7. Berkeley Lab Scientist Named MacArthur ''Genius'' Fellow for Audio Preservation Research

    SciTech Connect

    Haber, Carl

    2013-09-24

    Audio Preservationist Carl Haber was named a MacArthur Fellow in 2013. The Fellowship is a $625,000, no-strings-attached grant for individuals who have shown exceptional creativity in their work and the promise to do more. Learn more at http://www.macfound.org/fellows.

  8. Berkeley Lab Scientist Named MacArthur ''Genius'' Fellow for Audio Preservation Research

    ScienceCinema

    Haber, Carl

    2013-10-22

    Audio Preservationist Carl Haber was named a MacArthur Fellow in 2013. The Fellowship is a $625,000, no-strings-attached grant for individuals who have shown exceptional creativity in their work and the promise to do more. Learn more at http://www.macfound.org/fellows.

  9. Assessing Internalizing, Externalizing, and Attention Problems in Young Children: Validation of the MacArthur HBQ

    ERIC Educational Resources Information Center

    Lemery-Chalfant, Kathryn; Schreiber, Jane E.; Schmidt, Nicole L.; Van Hulle, Carol A.; Essex, Marilyn J.; Goldsmith, H. H.

    2007-01-01

    Objective: To test the validity of the MacArthur Health and Behavior Questionnaire (HBQ) using receiver operating characteristic (ROC) analysis to determine optimal thresholds for the HBQ in predicting Diagnostic Interview Schedule for Children Version-IV (DISC-IV)diagnoses. The roles of child sex, level of impairment, and physical health in…

  10. Reconsidering Arthur Bestor: A Postmortem for the Cold War in Education?

    ERIC Educational Resources Information Center

    Weltman, Burton

    This essay traces the liberal to conservative changes in U.S. political attitudes and the effect these changes had on progressive and essentialist theories of education from the 1940s to the present. Focus is on the role Arthur Bestor played in these developments. Bestor was a leader of the anti-progressive movement during the 1950s and the most…

  11. Research for the Classroom: Playing with Difficult Poetry--High School Seniors and Arthur Sze's "Quipu"

    ERIC Educational Resources Information Center

    Fogle, Andy

    2012-01-01

    The author had been assigned two sections of Contemporary Literature, a semester-long senior elective, and he wanted to do something new with poetry. He planned to teach Arthur Sze's "Quipu." Sze's poetry is nonlinear, adopting principles from science, anthropology, and history into a multilayered poetic texture--text unlike anything students…

  12. Educating the U.S. Army: Arthur L. Wagner and Reform, 1875-1905.

    ERIC Educational Resources Information Center

    Brereton, T. R.

    Arthur Lockwood Wagner, who graduated from West Point in 1876, was one of the best known and most influential U.S. Army officers of his day. An intellectual and educator, Wagner was instrumental in some of the most critical reforms in U.S. Army history. He advocated enhanced military education, adopting modern combat techniques, holding…

  13. ASCANs Harris, Helms, and McArthur during survival training at Fairchild AFB

    NASA Technical Reports Server (NTRS)

    1990-01-01

    1990 Group 13 Astronaut Candidates (ASCANs) (left to right) Bernard J. Harris, Jr, Susan J. Helms, and William S. McArthur, Jr open dehydrated food packages during wilderness survival training at Fairchild Air Force Base (AFB) in Spokane, Washington. The training was conducted in the mountain forests of Washington from 08-26-90 through 08-30-90.

  14. 77 FR 47284 - Safety Zone; Dredge Arthur J, Lake Huron, Lakeport, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-08

    .... SUPPLEMENTARY INFORMATION: Table of Acronyms DHS Department of Homeland Security FR Federal Register NPRM Notice... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Dredge Arthur J, Lake Huron, Lakeport, MI... temporary safety zone on lower Lake Huron, Lakeport, MI. This safety zone is intended to restrict...

  15. Predicting Outcomes of Children Referred for Autism Using the MacArthur-Bates Communicative Development Inventory

    ERIC Educational Resources Information Center

    Luyster, Rhiannon; Qiu, Shanping; Lopez, Kristina; Lord, Catherine

    2007-01-01

    Purpose: Autism spectrum disorders (ASD) are characterized by early impairments in language and related social communication skills. This investigation explored whether scores on the MacArthur-Bates Communicative Development Inventory (CDI) at ages 2 and 3 years predict outcome at age 9 years in children with ASD and developmental delay (DD).…

  16. Short-Form Versions of the Spanish MacArthur-Bates Communicative Development Inventories

    ERIC Educational Resources Information Center

    Jackson-Maldonodo, Donna; Marchman, Virginia A.; Fernald, Lia C. H.

    2013-01-01

    The Spanish-language MacArthur-Bates Communicative Development Inventories (S-CDIs) are well-established parent report tools for assessing the language development of Spanish-speaking children under 3 years. Here, we introduce the short-form versions of the S-CDIs (SFI and SFII), offered as alternatives to the long forms for screening purposes or…

  17. Arthur[R] Presents Hooray for Health! A Health Curriculum for Children.

    ERIC Educational Resources Information Center

    Schottman, Elly, Ed.

    This health curriculum for teachers, after-school providers, and school nurses uses the cartoon character Arthur to introduce four units that explore four distinct early childhood health themes. The themes are: "Eat Well. Stay Fit" (good nutrition and exercise); "Open Wide!" (dental health); "Dealing with Feelings" (emotions); and "Head Lice…

  18. Beetle Kill Wall at NREL

    SciTech Connect

    2010-01-01

    When it comes to designing an interior decorative feature for one of the most energy efficient office buildings in the world, very few would consider bringing in a beetle to do the job. But thats what happened at the U.S. Department of Energy's (DOE) Research Support Facility (RSF) located on the National Renewable Energy Laboratory (NREL) campus.In June, the RSF will become home to more than 800 workers from DOE and NREL and building visitors will be greeted with a soaring, two-story high wall entirely covered with wood harvested from the bark beetle infestation that has killed millions of pine trees in the Western U.S. But, the use of beetle kill wood is just one example of the resources being leveraged to make the RSF a model for sustainability and one more step toward NRELs goal to be a net zero energy campus.

  19. Beetle Kill Wall at NREL

    ScienceCinema

    None

    2013-05-29

    When it comes to designing an interior decorative feature for one of the most energy efficient office buildings in the world, very few would consider bringing in a beetle to do the job. But thats what happened at the U.S. Department of Energy's (DOE) Research Support Facility (RSF) located on the National Renewable Energy Laboratory (NREL) campus.In June, the RSF will become home to more than 800 workers from DOE and NREL and building visitors will be greeted with a soaring, two-story high wall entirely covered with wood harvested from the bark beetle infestation that has killed millions of pine trees in the Western U.S. But, the use of beetle kill wood is just one example of the resources being leveraged to make the RSF a model for sustainability and one more step toward NRELs goal to be a net zero energy campus.

  20. Blood Clots That Kill: Preventing DVT

    MedlinePlus

    ... on. Feature: Deep Vein Thrombosis Blood Clots That Kill: Preventing DVT Past Issues / Spring 2011 Table of ... More "Deep Vein Thrombosis" Articles Blood Clots That Kill: Preventing DVT / Skater Tara Lipinski Speaks Out About ...

  1. From the Cognitive to the Biological: A Sketch of Arthur Jensen's Contributions to the Study of "g."

    ERIC Educational Resources Information Center

    Vernon, Philip A.

    1998-01-01

    Describes Arthur Jensen's contributions to the study of general intelligence ("g"). His research has led to studies of genetic intelligence and speed of cognitive processing and the study of biological correlates of "g." (SLD)

  2. Reginald Crundall Punnett: First Arthur Balfour Professor of Genetics, Cambridge, 1912

    PubMed Central

    Edwards, A. W. F.

    2012-01-01

    R. C. Punnett, the codiscoverer of linkage with W. Bateson in 1904, had the good fortune to be invited to be the first Arthur Balfour Professor of Genetics at Cambridge University, United Kingdom, in 1912 when Bateson, for whom it had been intended, declined to leave his new appointment as first Director of the John Innes Horticultural Institute. We here celebrate the centenary of the first professorship dedicated to genetics, outlining Punnett’s career and his scientific contributions, with special reference to the discovery of “partial coupling” in the sweet pea (later “linkage”) and to the diagram known as Punnett’s square. His seeming reluctance as coauthor with Bateson to promote the reduplication hypothesis to explain the statistical evidence for linkage is stressed, as is his relationship with his successor as Arthur Balfour Professor, R. A. Fisher. The background to the establishment of the Professorship is also described. PMID:22964834

  3. Arthur C. Graesser: Award for Distinguished Contributions of Applications of Psychology to Education and Training.

    PubMed

    2011-11-01

    Presents Arthur C. Graesser as the 2011 winner of the American Psychological Association Award for Distinguished Contributions of Applications of Psychology to Education and Training. "As a multifaceted psychologist, cognitive engineer of useful education and training technologies, and mentor of new talent for the world of applied and translational cognitive science, Arthur C. Graesser is the perfect role model, showing how a strong scholar and intellect can shape both research and practice. His work is a mix of top-tier scholarship in psychology, education, intelligent systems, and computational linguistics. He combines cognitive science excellence with bold use of psychological knowledge and intelligent systems to design new generations of learning opportunities and to help lay the foundation for a translational science of learning." (PsycINFO Database Record (c) 2011 APA, all rights reserved). PMID:22082402

  4. Astronaut William McArthur in medical experiment in SLS-2

    NASA Technical Reports Server (NTRS)

    1993-01-01

    Astronaut William S. McArthur, mission specialist, participates in an experiment using the rebreathing assembly and a gas analyzer mass spectrometer that investigates in-space distribution and movement of blood and gas in the pulmonary system. The data gathered during the two-week flight will be compared with results of tests performed on Earth to determine the changes that occur in pulmonary functions.

  5. Cross-Cultural Adaptations of the MacArthur Competence Assessment Tool for Treatment in Iran

    PubMed Central

    Saber, Ali; Tabatabaei, Seyed Mahmoud; Akasheh, Goodarz; Sehat, Mojtaba; Zanjani, Zahra; Larijani, Bagher

    2016-01-01

    Background According to general ethical and legal principles, valid consent must be obtained before starting any procedure. Objectives Due to the lack of a standard tool for assessing patients’ capacity to consent to medical treatment in Iran, the present study was carried out aiming to devise a Persian version of a cross-cultural adaptation of the MacArthur competence assessment tool. Patients and Methods By reviewing different methods of cultural translation and adaptation for assessment tools, and due to the lack of consensus on its processes, we selected Wild’s model as one of the most comprehensive methods in this regard. Wild’s (2005) 10-stage model includes preparation, forward translation, reconciliation of the forward translation, back translation of reconciliation, back translation review, cognitive debriefing and cognitive review, and finalization, proofreading and final reporting. Using this model, we translated the MacArthur assessment tool and made it adaptable to Iranian patients. Results The MacArthur assessment tool is not dependent on any specific culture and language. As a result, if translation and its scientific adaptation are done based on an integrated and detailed model, the tool can be used for every culture and language. In other words, this tool is not culture-specific; so, it is applicable in cases where a translation is needed, and it can be culturally adapted to suit different societies. Conclusions In the present study, we are able to focus on and prove the efficacy and benefits of this measurement tool. PMID:27148503

  6. Fish kill from underwater explosions

    USGS Publications Warehouse

    Stuart, David J.

    1962-01-01

    The U.S. Geological Survey has used 23 different shotpoints during two seasons of field work in our seismic study of crustal structure in western United States. Without exception, it has been found that under-water shotpoints result in a more efficient conversion of explosive energy into seismic energy than do drilled-hole shotpoints. This experience, together with elimination of drilling costs, has led to the use of underwater shotpoints wherever possible. Three of the 23 shotpoints were in the Pacific Ocean, and for these we have no detailed information on the fish kill. Another six shotpoints were located in inland bodies of water. These are: * Soda Lake near Fallon, Nevada * Mono Lake near Lee Vining, California * Lake Mead near Boulder City, Nevada * Shasta Lake near Redding, California * C.J. Strike Reservoir near Bruneau, Idaho * Lucky Peak Reservoir near Boise, Idaho The 22 high-explosive charges, weighing a total of 95,100 pounds, that were fired in lakes containing fish life resulted in the known death of 2,413 game fish with a total weight of 759 pounds. The average mortality was 110 game fish or 34.5 pounds of game fish killed per average shot of 4,325 pounds of high-explosives.

  7. An Analysis of the Extratropical Transition of Hurricane Arthur (2014) from a JPSS Proving Ground Perspective

    NASA Astrophysics Data System (ADS)

    Folmer, M. J.; Berndt, E.; Halverson, J. B.; Dunion, J. P.; Goldberg, M.

    2015-12-01

    As part of the GOES-R and JPSS Satellite Proving Grounds, multiple proxy and operational products were available to analyze and forecast the complex evolution of Hurricane Arthur (2014). The National Hurricane Center, Ocean Prediction Center, Weather Prediction Center, and NESDIS Satellite Analysis Branch were able to monitor the tropical and extratropical transition of Arthur using various convective and red, green, blue (RGB) products that have been introduced in recent years. During the extratropical transition, the Air Mass RGB (AM RGB) product and AIRS/CrIS ozone products were available as a compliment to water vapor imagery to identify the upper-level low with associated stratospheric drying that absorbed much of Arthur's energy. The AM RGB product provides forecasters with an enhanced view of various air masses that are combined into a single image and can help differentiate between possible stratospheric/tropospheric interactions, moist tropical air masses, and cool, continental/maritime air masses. Even though this product provides a wealth of qualitative information about the horizontal distribution of synoptic features, forecasters are also interested in more quantitative information such as the vertical distribution of temperature, moisture, and ozone which impact the coloring of the resulting AM RGB. Currently, NOAA Unique CrIS/ATMS Processing System (NUCAPS) temperature and moisture soundings are available in AWIPS-II as a point-based display. Traditionally, soundings are used to anticipate and forecast severe convection, however unique and valuable information can be gained from soundings for other forecasting applications, such as extratropical transition, especially in data sparse regions. Additional research has been conducted to look at how NUCAPS soundings might help forecasters identify the pre-extratropical transition environment, leading to earlier diagnosis and better public advisories. NUCAPS soundings, AIRS soundings, NOAA G-IV GPS

  8. A kill curve for Phanerozoic marine species

    NASA Technical Reports Server (NTRS)

    Raup, D. M.

    1991-01-01

    A kill curve for Phanerozoic species is developed from an analysis of the stratigraphic ranges of 17,621 genera, as compiled by Sepkoski. The kill curve shows that a typical species' risk of extinction varies greatly, with most time intervals being characterized by very low risk. The mean extinction rate of 0.25/m.y. is thus a mixture of long periods of negligible extinction and occasional pulses of much higher rate. Because the kill curve is merely a description of the fossil record, it does not speak directly to the causes of extinction. The kill curve may be useful, however, to li inverted question markmit choices of extinction mechanisms.

  9. Timelike Killing spinors in seven dimensions

    SciTech Connect

    Cariglia, Marco; Conamhna, Oisin A.P. Mac

    2004-12-15

    We employ the G-structure formalism to study supersymmetric solutions of minimal and SU(2) gauged supergravities in seven dimensions admitting Killing spinors with an associated timelike Killing vector. The most general such Killing spinor defines a SU(3) structure. We deduce necessary and sufficient conditions for the existence of a timelike Killing spinor on the bosonic fields of the theories, and find that such configurations generically preserve one out of 16 supersymmetries. Using our general supersymmetric ansatz we obtain numerous new solutions, including squashed or deformed anti-de Sitter solutions of the gauged theory, and a large class of Goedel-like solutions with closed timelike curves.

  10. Arthur Beer and his relations to Einstein and to the Warburg library (German Title: Arthur Beer und seine Beziehungen zu Einstein und zur Warburg-Bibliothek)

    NASA Astrophysics Data System (ADS)

    Duerbeck, Hilmar W.; Beer, Peter

    We give an account of the scientific life of Arthur Beer (1900-1980). Born in Reichenberg, Bohemia, he studied in Leipzig, Vienna and Berlin. After obtaining his Ph.D., he worked with the Seewarte (maritime observatory) and with the Warburg Library, both in Hamburg. Because of his relations with Finlay Freundlich, Einstein and Fritz Saxl, he succeeded in emigrating to England in 1934, where he obtained a temporary position at Cambridge Observatory, and carried out astrophysical research under F.J.M. Stratton. After shorter stays at the observatories of Mill Hill and Kew, both in the vicinity of London, he obtained, after World War II, the position of Senior Assistant Observer in Cambridge. Besides his studies in astrophysics and the history of astronomy, he is best known as the founding editor of the series "Vistas in Astronomy".

  11. Binary black hole spacetimes with a helical Killing vector

    SciTech Connect

    Klein, Christian

    2004-12-15

    Binary black hole spacetimes with a helical Killing vector, which are discussed as an approximation for the early stage of a binary system, are studied in a projection formalism. In this setting the four-dimensional Einstein equations are equivalent to a three-dimensional gravitational theory with a SL(2,R)/SO(1,1) sigma model as the material source. The sigma model is determined by a complex Ernst equation. 2+1 decompositions of the three-metric are used to establish the field equations on the orbit space of the Killing vector. The two Killing horizons of spherical topology which characterize the black holes, the cylinder of light where the Killing vector changes from timelike to spacelike, and infinity are singular points of the equations. The horizon and the light cylinder are shown to be regular singularities, i.e., the metric functions can be expanded in a formal power series in the vicinity. The behavior of the metric at spatial infinity is studied in terms of formal series solutions to the linearized Einstein equations. It is shown that the spacetime is not asymptotically flat in the strong sense to have a smooth null infinity under the assumption that the metric tends asymptotically to the Minkowski metric. In this case the metric functions have an oscillatory behavior in the radial coordinate in a nonaxisymmetric setting, the asymptotic multipoles are not defined. The asymptotic behavior of the Weyl tensor near infinity shows that there is no smooth null infinity.

  12. Bull heading to kill live gas wells

    SciTech Connect

    Oudeman, P.; Avest, D. ter; Grodal, E.O.; Asheim, H.A.; Meissner, R.J.H.

    1994-12-31

    To kill a live closed-in gas well by bull heading down the tubing, the selected pump rate should be high enough to ensure efficient displacement of the gas into the formation (i.e., to avoid the kill fluid bypassing the gas). On the other hand, the pressures that develop during bull heading at high rate must not exceed wellhead pressure rating, tubing or casing burst pressures or the formation breakdown gradient, since this will lead, at best, to a very inefficient kill job. Given these constraints, the optimum kill rate, requited hydraulic horsepower, density and type of kill fluids have to be selected. For this purpose a numerical simulator has been developed, which predicts the sequence of events during bull heading. Pressures and flow rates in the well during the kill job are calculated, taking to account slip between the gas and kill fluid, hydrostatic and friction pressure drop, wellbore gas compression and leak-off to the formation. Comparison with the results of a dedicated field test demonstrates that these parameters can be estimated accurately. Example calculations will be presented to show how the simulator can be used to identify an optimum kill scenario.

  13. Arthur Compton's 1941 Analysis of Explosive Fission in U-235: The Physics

    NASA Astrophysics Data System (ADS)

    Reed, Cameron

    2008-04-01

    In November 1941 Arthur Compton prepared a report for Vannevar Bush regarding the possibility of explosive fission of U-235. This remarkable report, arguably the parent document of the Los Alamos Primer, presented detailed estimates for the critical mass, expected energy release, efficiency, destructive effects and probable cost of such a weapon. This paper will examine the physics behind Compton's estimates for the critical mass and efficiency of a fission weapon and compare his results to those derived from present-day cross-sections and secondary-neutron numbers. His approach to the efficiency calculation is found to be particularly interesting in that it utilizes some very basic undergraduate physics.

  14. Remembering Arthur Kornhauser: industrial psychology's advocate for worker well-being.

    PubMed

    Zickar, Michael J

    2003-04-01

    Arthur Kornhauser was an early industrial psychologist whose contributions have been neglected in written histories of applied psychology. Throughout his career, he was a staunch advocate for an industrial psychology that concentrated on improving workers' lives. This article describes his contributions to improving worker well-being in the research areas of testing, employee attitude surveying, labor unions, and mental health of workers. His most enduring quality was his outspoken advocacy for an industrial psychology that addressed workers' issues instead of management's prerogatives. On the basis of Kornhauser's accomplishments, a case can be made for him as one of industrial and organizational psychology's most important early figures. PMID:12731721

  15. [Arthur Kronfeld (1886-1941)--a psychiatrist in the service of psychotherapy].

    PubMed

    Schröder, C

    1986-07-01

    The psychotherapeutic life-work of psychiatrist Arthur Kronfeld has almost fallen into oblivion. Against the background of the 100th anniversary of his birth the author traces Kronfeld's psychotherapeutic career, pointing out his activity at the Berliner "Institute of Sexual Research" under Magnus Hirschfeld, and his psychotherapeutic concept--the psychagogic guidance of the patient--and its connection with the individual psychology of Alfred Adler. Kronfeld translated his theoretical positions into activities directed towards socialization and the teachability of psychotherapy which are still worthy of note by those engaged in the field. PMID:3532156

  16. Fishy Hearing: A Short Biography of Arthur N. Popper, PhD.

    PubMed

    Coffin, Allison B

    2016-01-01

    Biologist Dr. Arthur Popper's career spans decades, from his early work on comparative inner ear morphology in fishes to his recent interest in how underwater noise impacts aquatic vertebrates. Along the way Dr. Popper's research subjects span at least 19 vertebrate taxa, from lamprey to lungfish to humans, and he's had a profound influence in the field of fish bioacoustics. This brief biography describes some of Dr. Popper's many contributions to fish hearing research and highlights both some of his major discoveries and some of the biological mysteries he has yet to solve. PMID:26515307

  17. Two-message quantum-Arthur-Merlin game with single-qubit measurements

    NASA Astrophysics Data System (ADS)

    Morimae, Tomoyuki

    2016-06-01

    We show that the class quantum-Arthur-Merlin (QAM) does not change even if the verifier's ability is restricted to only single-qubit measurements. To show the result, we use the idea of measurement-based quantum computing: the verifier, who can do only single-qubit measurements, can test the graph state sent from the prover and use it for his measurement-based quantum computing. Inspired by this construction, we also introduce a problem which we call stabilizer state optimization, and show that it is QMA-complete.

  18. Momentum kill procedure can quickly control blowouts

    SciTech Connect

    Watson, W.D. ); Moore, P. )

    1993-08-30

    The momentum kill method can help in quickly regaining control of a blowing well, providing the blowing well rate and fluid properties can be estimated reasonably. The momentum of the kill fluid counteracts and overcomes the flowing momentum of formation fluids. In other words, sufficient mud density pumped at a sufficient rate is directed into the flow stream to force the escaping fluid column back into the well bore. Sufficient kill fluid hydrostatic pressure must be stacked'' in the hole so that the well remains dead after the operation. The momentum kill is not a panacea for all blowouts. An assessment must be made of the potential problems unique to this method, and certain requirements must be met if the technique is to be successful. The paper discusses some of the considerations for evaluating the use of the momentum kill method.

  19. Mount Unzen kills three volcanologists

    NASA Astrophysics Data System (ADS)

    DeVito, M. Catherine

    Three AGU members were among 37 people killed June 3 when Mount Unzen, a volcano in Nagasaki prefecture, Japan, erupted. Unzen last erupted in 1792. The first signs of renewed activity appeared in mid-1990, with increases in seismicity and the first volcanic tremor since observations began in 1966. The three volcanologists, Harry Glicken and Maurice and Katia Krafft, had traveled to Mount Unzen to monitor the increased seismic activity. Glicken, 33, was a visiting scientist at Tokyo Metropolitan University and an assistant researcher in geological sciences at the University of California, Santa Barbara. He worked for the U.S. Geological Survey until 1989, and narrowly escaped death in the 1980 eruption of Mount St. Helens in Washington.Glicken had been an AGU member since 1980 and was known for his work in debris avalanches. Maurice, 45, and Katia Krafft, 44, of Cernay, France, were professional volcanologists known for their extensive work in publishing books and films on volcanology for the general public. Both Kraffts joined AGU in 1975.

  20. 3 CFR - Expediting Review of Pipeline Projects From Cushing, Oklahoma, to Port Arthur, Texas, and Other...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... our trade balance—creating jobs and supporting domestic industry. In order to realize these potential... efficient cars and trucks, and a world-class refining sector that last year was a net exporter of...

  1. [Arthur Simons on tonic neck reflexes in persons with hemiplegia. From the years 1916 to 1919].

    PubMed

    Holdorff, B

    2012-04-01

    Tonic neck reflexes described in 1921 by Magnus and deKlejn in animals and men were studied in hemiplegic patients who were mainly victims of WWI by Arthur Simons, a neurologist in Berlin and coworker of Hermann Oppenheim. The effect of the asymmetric neck reflexes after head rotation was restricted to the paralyzed side: tonus (spasms) of extension and adduction during mid-position of the head or head version to the paralyzed side; flexion tonus and abduction during head version to the non-paralyzed side; and flexion tonus (spasms) of the paralyzed limbs during flexion of the head and extension spasms by head extension. More than this, hemiplegic "Mitbewegungen" or associated reactions (Walshe) were observed. They are elicited by conscious innervations of the unaffected side, e.g. by fist closure, and are increased or varied by head rotation, the tonic neck reflexes. They occurred in 25%. A film with Arthur Simons as examiner from the years 1916-1919 shows these nearly forgotten phenomena. Their everyday significance was already stressed in 1920, long before the rules of antispastic positions were defined by Bobath. PMID:21845452

  2. Islands as model systems in ecology and evolution: prospects fifty years after MacArthur-Wilson.

    PubMed

    Warren, Ben H; Simberloff, Daniel; Ricklefs, Robert E; Aguilée, Robin; Condamine, Fabien L; Gravel, Dominique; Morlon, Hélène; Mouquet, Nicolas; Rosindell, James; Casquet, Juliane; Conti, Elena; Cornuault, Josselin; Fernández-Palacios, José María; Hengl, Tomislav; Norder, Sietze J; Rijsdijk, Kenneth F; Sanmartín, Isabel; Strasberg, Dominique; Triantis, Kostas A; Valente, Luis M; Whittaker, Robert J; Gillespie, Rosemary G; Emerson, Brent C; Thébaud, Christophe

    2015-02-01

    The study of islands as model systems has played an important role in the development of evolutionary and ecological theory. The 50th anniversary of MacArthur and Wilson's (December 1963) article, 'An equilibrium theory of insular zoogeography', was a recent milestone for this theme. Since 1963, island systems have provided new insights into the formation of ecological communities. Here, building on such developments, we highlight prospects for research on islands to improve our understanding of the ecology and evolution of communities in general. Throughout, we emphasise how attributes of islands combine to provide unusual research opportunities, the implications of which stretch far beyond islands. Molecular tools and increasing data acquisition now permit re-assessment of some fundamental issues that interested MacArthur and Wilson. These include the formation of ecological networks, species abundance distributions, and the contribution of evolution to community assembly. We also extend our prospects to other fields of ecology and evolution - understanding ecosystem functioning, speciation and diversification - frequently employing assets of oceanic islands in inferring the geographic area within which evolution has occurred, and potential barriers to gene flow. Although island-based theory is continually being enriched, incorporating non-equilibrium dynamics is identified as a major challenge for the future. PMID:25560682

  3. Spacetime encodings. III. Second order Killing tensors

    SciTech Connect

    Brink, Jeandrew

    2010-01-15

    This paper explores the Petrov type D, stationary axisymmetric vacuum (SAV) spacetimes that were found by Carter to have separable Hamilton-Jacobi equations, and thus admit a second-order Killing tensor. The derivation of the spacetimes presented in this paper borrows from ideas about dynamical systems, and illustrates concepts that can be generalized to higher-order Killing tensors. The relationship between the components of the Killing equations and metric functions are given explicitly. The origin of the four separable coordinate systems found by Carter is explained and classified in terms of the analytic structure associated with the Killing equations. A geometric picture of what the orbital invariants may represent is built. Requiring that a SAV spacetime admits a second-order Killing tensor is very restrictive, selecting very few candidates from the group of all possible SAV spacetimes. This restriction arises due to the fact that the consistency conditions associated with the Killing equations require that the field variables obey a second-order differential equation, as opposed to a fourth-order differential equation that imposes the weaker condition that the spacetime be SAV. This paper introduces ideas that could lead to the explicit computation of more general orbital invariants in the form of higher-order Killing tensors.

  4. [Killing of cattle via electrical stunning].

    PubMed

    Maurer, B; Forster, S

    2007-04-01

    For disease control in the case of epidemics killing of cattle via electrical stunning is a method of choice. The official veterinarian is responsible for monitoring the adhesion to animal welfare principles during electrical stunning and killing. This requires specialised knowledge and experience as the symptoms of effective stunning are quite variable in cattle. Signs of effective and ineffective stunning are described below. In addition to suitable technical equipment, restraint of the animals and correct use of the equipment, neurophysiological processes have to be considered. Calm handling of the animals avoiding stress is a prerequisite for ensuring animal welfare and minimising pain especially when killing cattle using electrical methods. PMID:17484500

  5. Killing Initial Data on spacelike conformal boundaries

    NASA Astrophysics Data System (ADS)

    Paetz, Tim-Torben

    2016-08-01

    We analyze Killing Initial Data on Cauchy surfaces in conformally rescaled vacuum space-times satisfying Friedrich's conformal field equations. As an application, we derive the KID equations on a spacelike ℐ-.

  6. Quantum integrability of quadratic Killing tensors

    SciTech Connect

    Duval, C.; Valent, G.

    2005-05-01

    Quantum integrability of classical integrable systems given by quadratic Killing tensors on curved configuration spaces is investigated. It is proven that, using a 'minimal' quantization scheme, quantum integrability is ensured for a large class of classic examples.

  7. Conserved quantities from piecewise Killing vectors

    NASA Astrophysics Data System (ADS)

    Dray, Tevian; Padmanabhan, T.

    1989-07-01

    In the presence of symmetries, conserved quantities can be obtained by contracting the stress-energy tensor with a Killing vector. We generalize this result to piecewise Killing vectors by giving sufficient conditions for the construction of an associated conserved quantity. A typical example, namely, two stationary space-times joined together in such a way that the resulting space-time is not stationary, is treated in detail.

  8. Killing vector fields and harmonic superfield theories

    NASA Astrophysics Data System (ADS)

    Groeger, Josua

    2014-09-01

    The harmonic action functional allows a natural generalisation to semi-Riemannian supergeometry, also referred to as harmonic, which resembles the supersymmetric sigma models studied in high energy physics. We show that Killing vector fields are infinitesimal supersymmetries of this harmonic action and prove three different Noether theorems in this context. En passant, we provide a homogeneous treatment of five characterisations of Killing vector fields on semi-Riemannian supermanifolds, thus filling a gap in the literature.

  9. Killing vector fields and harmonic superfield theories

    SciTech Connect

    Groeger, Josua

    2014-09-15

    The harmonic action functional allows a natural generalisation to semi-Riemannian supergeometry, also referred to as harmonic, which resembles the supersymmetric sigma models studied in high energy physics. We show that Killing vector fields are infinitesimal supersymmetries of this harmonic action and prove three different Noether theorems in this context. En passant, we provide a homogeneous treatment of five characterisations of Killing vector fields on semi-Riemannian supermanifolds, thus filling a gap in the literature.

  10. Killing-Yano tensors, rank-2 Killing tensors, and conserved quantities in higher dimensions

    NASA Astrophysics Data System (ADS)

    Krtous, Pavel; Kubiznák, David; Page, Don N.; Frolov, Valeri P.

    2007-02-01

    From the metric and one Killing-Yano tensor of rank D-2 in any D-dimensional spacetime with such a principal Killing-Yano tensor, we show how to generate k = [(D+1)/2] Killing-Yano tensors, of rank D-2j for all 0 <= j <= k-1, and k rank-2 Killing tensors, giving k constants of geodesic motion that are in involution. For the example of the Kerr-NUT-AdS spacetime (hep-th/0604125) with its principal Killing-Yano tensor (gr-qc/0610144), these constants and the constants from the k Killing vectors give D independent constants in involution, making the geodesic motion completely integrable (hep-th/0611083). The constants of motion are also related to the constants recently obtained in the separation of the Hamilton-Jacobi and Klein-Gordon equations (hep-th/0611245).

  11. Killing of Actinobacillus actinomycetemcomitans by human lactoferrin.

    PubMed Central

    Kalmar, J R; Arnold, R R

    1988-01-01

    Actinobacillus actinomycetemcomitans is a fastidious, facultative gram-negative rod associated with endocarditis, certain forms of periodontal disease, and other focal infections. Human neutrophils have demonstrated bactericidal activity against A. actinomycetemcomitans, and much of the oxygen-dependent killing has been attributed to the myeloperoxidase-H2O2-halide system. However, the contribution of other neutrophil components to killing activity is obscure. Lactoferrin, an iron-binding glycoprotein, is a major constituent of neutrophil-specific granules and is also found in mucosal secretions. In this report, we show that human lactoferrin is bactericidal for A. actinomycetemcomitans. Killing activity required an unsaturated (iron- and anion-free) molecule that produced a 2-log decrease in viability within 120 min at 37 degrees C at a concentration of 1.9 microM. Besides exhibiting concentration dependence, killing kinetics were affected by minor variations in temperature and pH. Magnesium, a divalent cation thought to stabilize lipopolysaccharide interactions on the surface of gram-negative organisms, enhanced lactoferrin killing of A. actinomycetemcomitans, while other cations, such as potassium and calcium, had no effect. Our data suggest that lactoferrin contributes to killing of A. actinomycetemcomitans by human neutrophils and that it may also play a significant role in innate secretory defense against this potential periodontopathogen. PMID:3417349

  12. Hazardous materials in Fresh Kills landfill

    SciTech Connect

    Hirschhorn, J.S.

    1997-12-31

    No environmental monitoring and corrective action programs can pinpoint multiple locations of hazardous materials the total amount of them in a large landfill. Yet the consequences of hazardous materials in MSW landfills are considerable, in terms of public health concerns, environmental damage, and cleanup costs. In this paper a rough estimation is made of how much hazardous material may have been disposed in Fresh Kills landfill in Staten Island, New York. The logic and methods could be used for other MSW landfills. Fresh Kills has frequently been described as the world`s largest MSW landfill. While records of hazardous waste disposal at Fresh Kills over nearly 50 years of operation certainly do not exist, no reasonable person would argue with the conclusion that large quantities of hazardous waste surely have been disposed at Fresh Kills, both legally and illegally. This study found that at least 2 million tons of hazardous wastes and substances have been disposed at Fresh Kills since 1948. Major sources are: household hazardous waste, commercial RCRA hazardous waste, incinerator ash, and commercial non-RCRA hazardous waste, governmental RCRA hazardous waste. Illegal disposal of hazardous waste surely has contributed even more. This is a sufficient amount to cause serious environmental contamination and releases, especially from such a landfill without an engineered liner system, for example. This figure is roughly 1% of the total amount of waste disposed in Fresh Kills since 1948, probably at least 200 million tons.

  13. Reception of Arthur Sutherland Neill's Pedagogical Concept and His Summerhill School in Hungarian and German Pedagogical Literature and Press

    ERIC Educational Resources Information Center

    Langer-Buchwald, Judit

    2010-01-01

    Arthur Sutherland Neill is one of the most debated personalities among the representatives of the classic reform pedagogy, due to his pedagogical concept and its practical realization, and his Summerhill School, equally. He is often mentioned during public debates, where mostly the "three S"--"sex, swearing and smoking", are existing as subject of…

  14. The Complexity of Intellectual Currents: Duncan McArthur and Ontario's Progressivist Curriculum Reforms

    ERIC Educational Resources Information Center

    Christou, Theodore Michael

    2013-01-01

    This paper concentrates on a seminal figure in the history of Canadian education who has never previously been the subject of historical examination: Duncan McArthur. As Deputy Minister, then Minister of Education, in Ontario between 1934 and 1942, he guided the province's public schools during a period of dramatic reorganisation within a…

  15. 75 FR 16456 - Adequacy Status of the Beaumont-Port Arthur, TX Maintenance Plan; 8-Hour Ozone Motor Vehicle...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-01

    ...; Transportation Conformity Rule Amendments: Response to Court Decision and Additional Rule Changes'' (69 FR 40004... been made, pursuant to 40 CFR 93.104(e). See, 73 FR 4419 (January 24, 2008). Authority: 42 U.S.C. 7401... motor vehicle emissions budgets (MVEB) in the Beaumont-Port Arthur, Texas (BPA) Redesignation...

  16. Creativity Is More than Silly, More than Art, More than Good: The Diverse Career of Arthur Cropley

    ERIC Educational Resources Information Center

    Kaufman, James C.

    2015-01-01

    In this article, I highlight some of Arthur Cropley's work that has been the most influential to me as a scholar. Cropley's work has continually pushed the boundaries by exploring what creativity is and isn't, squashing myths, and not making assumptions. I specifically discuss Cropley's research and theory on the importance of convergent thinking,…

  17. Rural Workplace Literacy Demonstration Project. Final Performance Report.

    ERIC Educational Resources Information Center

    Enterprise State Junior Coll., AL.

    In April 1991, Enterprise State Junior College and MacArthur State Technical College established a rural workplace literacy demonstration project in partnership with adult basic education, seven employers, and a labor organization. The project served 615 persons in classes offered at the 2 colleges, 4 partner locations, and 3 additional worksites.…

  18. New School Art Styles: The Project of Art Education

    ERIC Educational Resources Information Center

    Gude, Olivia

    2013-01-01

    Art projects are appropriate building blocks for visual art curriculum because good art projects encode complex aesthetic strategies, giving students tools to investigate and make meaning. Art made in schools will inevitably be some form of "school art," defined by Arthur Efland in "The School Art Style: a Functional Analysis,"…

  19. The MacArthur Maze Fire and Roadway Collapse: Consequences for SNF Transportation - 12476

    SciTech Connect

    Bajwa, Christopher S.; Easton, Earl P.; Adkins, Harold; Cuta, Judith; Klymyshyn, Nicholas; Suffield, Sarah

    2012-07-01

    In 2007, a severe transportation accident occurred near Oakland, California, on a section of Interstate 880 known as the 'MacArthur Maze', involving a tractor trailer carrying gasoline which impacted an overpass support column and burst into flames. The subsequent fire caused the collapse of portions of the Interstate 580 overpass onto the remains of the tractor-trailer in less than 20 minutes, due to a reduction of strength in the structural steel exposed to the fire. The US Nuclear Regulatory Commission is in the process of examining the impacts of this accident on the performance of a spent nuclear fuel transportation package, using detailed analysis models, in order to determine the potential regulatory implications related to the safe transport of spent nuclear fuel in the United States. This paper will provide a summary of this effort and present results and conclusions. The detailed thermal models of the MacArthur Maze fire scenario with ANSYS and COBRASFS have produced preliminary results indicating that in a fire of this severity, the peak fuel cladding temperature would almost certainly exceed the short-term limit of 570 deg. C (1058 deg. F), and would likely exceed the Zircaloy burst temperature limit of 750 deg. C (1382 deg. F) assumed in previous transportation studies. Additional work is needed to refine and verify some of the details of these complex models, but the overall results are consistent with previous fire analyses with similar models, and with the results obtained for the HAC fire evaluations with these models. These results as well as future results produced by these models can therefore be considered as reliable estimates of the temperatures that would be experienced in fire conditions of the severity of the MacArthur Maze fire scenario. The structural analyses show that the GA-4 package is robust enough to withstand the impact of the overhead span without suffering major damage or deformation to the containment boundary. The greatest

  20. Influence of killing method on Lepidoptera DNA barcode recovery.

    PubMed

    Willows-Munro, Sandi; Schoeman, M Corrie

    2015-05-01

    The global DNA barcoding initiative has revolutionized the field of biodiversity research. Such large-scale sequencing projects require the collection of large numbers of specimens, which need to be killed and preserved in a way that is both DNA-friendly and which will keep voucher specimens in good condition for later study. Factors such as time since collection, correct storage (exposure to free water and heat) and DNA extraction protocol are known to play a role in the success of downstream molecular applications. Limited data are available on the most efficient, DNA-friendly protocol for killing. In this study, we evaluate the quality of DNA barcode (cytochrome oxidase I) sequences amplified from DNA extracted from specimens collected using three different killing methods (ethyl acetate, cyanide and freezing). Previous studies have suggested that chemicals, such as ethyl acetate and formaldehyde, degraded DNA and as such may not be appropriate for the collection of insects for DNA-based research. All Lepidoptera collected produced DNA barcodes of good quality, and our study found no clear difference in nucleotide signal strength, probability of incorrect base calling and phylogenetic utility among the three different treatment groups. Our findings suggest that ethyl acetate, cyanide and freezing can all be used to collect specimens for DNA analysis. PMID:25229871

  1. Better to light a candle: Arthur Barsky and global plastic surgery.

    PubMed

    Hughes, Christopher D; Barsky, Emily; Hagander, Lars; Barsky, Arthur J; Meara, John G

    2013-08-01

    Plastic and reconstructive surgery has had a long history with international humanitarian efforts. As the field of global surgery continues to gain momentum in academic centers throughout the world, the role of the surgical subspecialist in the public health infrastructure of low-resource communities has also begun to gain a new sense of wonder and importance. Arthur Barsky, Jr was arguably one of the most influential forefathers of global plastic surgery. Throughout his notable career spanning most of the 20th century, Barsky remained dedicated to delivering plastic and reconstructive surgical care to the disadvantaged worldwide, as well as educating others to do the same. Although he was not the first surgeon with an interest in global health, Barsky's work was unique and influential in its originality, magnitude, and scope. An appreciation and understanding of Barsky's groundbreaking work will help inform the future development of sustainable surgical systems in resource-poor settings. PMID:22868314

  2. [From Basel to Bad Nassau. The fate of the psychoanalyst Arthur Muthmann (1875-1957)].

    PubMed

    Müller, Thomas

    2003-01-01

    Arthur Muthmann is known as a pioneer of psychoanalysis in German-speaking countries. He published on the clinical application of psychoanalysis as well as an article explaining the matter to laymen. His Freiburg years and later work have already been portrayed, while his academic failure in Switzerland and his directorship of a private sanatorium at the famous Hessian spa of Bad Nassau have hardly been looked at. Historians of psychoanalysis reported on Muthmann's definite split from the psychoanalytic movement after 1909 due to the fiasco about his professoral thesis at Basel. His contribution to the spreading of psychoanalytic knowledge of the time has been judged upon harshly by known historians. Both hypotheses will be scrutinised here. PMID:15030054

  3. Arthur Beer and his relations with Einstein and the Warburg Institute

    NASA Astrophysics Data System (ADS)

    Duerbeck, Hilmar W.; Beer, Peter

    2006-06-01

    We give an account of the scientific life of Arthur Beer (1900-1980). Born in Reichenberg, Bohemia, he studied in Leipzig, Vienna and Berlin. After obtaining his Ph.D., he worked with the Seewarte (maritime observatory) and with the Warburg Library, both in Hamburg. Because of his relations with Finlay Freundlich, Albert Einstein and Fritz Saxl, he succeeded in emigrating to England in 1934, where he obtained a temporary position at Cambridge Observatory, and carried out astrophysical research under F.J.M. Stratton. After shorter stays at the observatories of Mill Hill and Kew, both in the vicinity of London, he obtained, after World War II, the position of Senior Assistant Observer in Cambridge. Besides his studies in astrophysics and the history of astronomy, he is best known as the founding Editor of the series Vistas in Astronomy.

  4. Cryptococcus Neoformans Modulates Extracellular Killing by Neutrophils

    PubMed Central

    Qureshi, Asfia; Grey, Angus; Rose, Kristie L.; Schey, Kevin L.; Del Poeta, Maurizio

    2011-01-01

    We recently established a key role for host sphingomyelin synthase (SMS) in regulating the killing activity of neutrophils against Cryptococcus neoformans. In this paper, we studied the effect of C. neoformans on the killing activity of neutrophils and whether SMS would still be a player against C. neoformans in immunocompromised mice lacking T and natural killer (NK) cells (Tgε26 mice). To this end, we analyzed whether C. neoformans would have any effect on neutrophil survival and killing in vitro and in vivo. We show that unlike Candida albicans, neither the presence nor the capsule size of C. neoformans cells have any effect on neutrophil viability. Interestingly, melanized C. neoformans cells totally abrogated the killing activity of neutrophils. We monitored how exposure of neutrophils to C. neoformans cells would interfere with any further killing activity of the conditioned medium and found that pre-incubation with live but not “heat-killed” fungal cells significantly inhibits further killing activity of the medium. We then studied whether activation of SMS at the site of C. neoformans infection is dependent on T and NK cells. Using matrix-assisted laser desorption–ionization tissue imaging in infected lung we found that similar to previous observations in the isogenic wild-type CBA/J mice, SM 16:0 levels are significantly elevated at the site of infection in mice lacking T and NK cells, but only at early time points. This study highlights that C. neoformans may negatively regulate the killing activity of neutrophils and that SMS activation in neutrophils appears to be partially independent of T and/or NK cells. PMID:21960987

  5. Killing of Brucella abortus by bovine serum.

    PubMed Central

    Corbeil, L B; Blau, K; Inzana, T J; Nielsen, K H; Jacobson, R H; Corbeil, R R; Winter, A J

    1988-01-01

    Studies of the serum bactericidal system in bovine brucellosis were undertaken to investigate the role of the humoral immune response in protection of cattle against the facultative intracellular parasite Brucella abortus. Fresh sera from normal control cattle, infected cattle, and cattle immunized with B. abortus cell envelopes were collected before treatment and during the course of immunization or infection. Normal fresh bovine serum or fresh agammaglobulinemic serum from colostrum-deprived calves was effective in killing smooth virulent B. abortus 2308, but rough strains RB51 (a rough mutant of strain 2308) and 45/20 were much more sensitive to serum. The difference in susceptibility to serum was shown to be correlated with differences in lipopolysaccharide chemotype, with the more resistant strain 2308 having O polysaccharide and the more susceptible strains 45/20 and RB51 lacking O side chains. By treatment of fresh serum with MgCl2 and EGTA [ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid] killing was shown to occur via the classical pathway of complement activation. When antibody to B. abortus was present, killing of strain RB51 increased but killing of smooth strain 2308 decreased. The earliest antibody response in serum from infected animals did not interfere with killing. When affinity-purified bovine immunoglobulins specific for B. abortus smooth lipopolysaccharide were added to fresh normal bovine serum, immunoglobulin G1 (IgG1) and IgG2 isotypes blocked killing but IgM and IgA isotypes did not. Thus, it appears that serum from previously unexposed animals or animals early during infection can kill smooth B. abortus, an appropriate defense mechanism before the organism becomes intracellular. At later stages of infection, blocking antibodies predominate. Images PMID:3141287

  6. Kill fluid for oil field operations

    SciTech Connect

    Sydansk, R.D.

    1990-08-14

    This patent describes a process employing a kill fluid to substantially reduce the volumetric flow of formation fluid into a wellbore penetrating a formation containing the formation fluid below an earthen surface. It comprises: admixing components of a continuous flowing gel at the surface comprising of water-soluble carboxylate-containing polymer, a complex capable of crosslinking the polymer and formed of at least one electropositive chromium III species and at least one electronegative carboxylatespecies, and an aqueous solvent for the polymer and the complex; crosslinking the polymer and the complex to form the gel, wherein the kill fluid comprises the gel; placing a volume of the kill fluid in the wellbore sufficient to create a hydrostatic head which exerts a kill fluid pressure against the formation fluid substantially equal to or greater than the formation fluid pressure and thereby substantially reduces the volumetric flow of the formation fluid into the wellbore; performing an oil field operation after placing the volume of the kill fluid in the wellbore; and removing the gel from the wellbore to substantially restore the volumetric flow of the formation fluid into the wellbore.

  7. Killing superalgebras for Lorentzian four-manifolds

    NASA Astrophysics Data System (ADS)

    de Medeiros, Paul; Figueroa-O'Farrill, José; Santi, Andrea

    2016-06-01

    We determine the Killing superalgebras underpinning field theories with rigid unextended supersymmetry on Lorentzian four-manifolds by re-interpreting them as filtered deformations of mathbb{Z} -graded subalgebras with maximum odd dimension of the N = 1 Poincaré superalgebra in four dimensions. Part of this calculation involves computing a Spencer cohomology group which, by analogy with a similar result in eleven dimensions, prescribes a notion of Killing spinor, which we identify with the defining condition for bosonic supersymmetric backgrounds of minimal off-shell supergravity in four dimensions. We prove that such Killing spinors always generate a Lie superalgebra, and that this Lie superalgebra is a filtered deformation of a subalgebra of the N = 1 Poincaré superalgebra in four dimensions. Demanding the flatness of the connection defining the Killing spinors, we obtain equations satisfied by the maximally supersymmetric backgrounds. We solve these equations, arriving at the classification of maximally supersymmetric backgrounds whose associated Killing superalgebras are precisely the filtered deformations we classify in this paper.

  8. Non-standard symmetries and Killing tensors

    NASA Astrophysics Data System (ADS)

    Visinescu, Mihai

    2009-10-01

    Higher order symmetries corresponding to Killing tensors are investigated. The intimate relation between Killing-Yano tensors and non-standard supersymmetries is pointed out. The gravitational anomalies are absent if the hidden symmetry is associated with a Killing-Yano tensor. In the Dirac theory on curved spaces, Killing-Yano tensors generate Dirac type operators involved in interesting algebraic structures as dynamical algebras or even infinite dimensional algebras or superalgebras. The general results are applied to space-times which appear in modern studies. The 4-dimensional Euclidean Taub-NUT space and its generalizations introduced by Iwai and Katayama are analyzed from the point of view of hidden symmetries. One presents the infinite dimensional superalgebra of Dirac type operators on Taub-NUT space that can be seen as a twisted loop algebra. The axial anomaly, interpreted as the index of the Dirac operator, is computed for the generalized Taub-NUT metrics. The existence of the conformal Killing-Yano tensors is investigated for some spaces with mixed Sasakian structures.

  9. 9 CFR 113.206 - Wart Vaccine, Killed Virus.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Wart Vaccine, Killed Virus. 113.206... AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.206 Wart Vaccine, Killed Virus. Wart Vaccine, Killed Virus, shall be...

  10. 9 CFR 113.206 - Wart Vaccine, Killed Virus.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Wart Vaccine, Killed Virus. 113.206... AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.206 Wart Vaccine, Killed Virus. Wart Vaccine, Killed Virus, shall be...

  11. 9 CFR 113.206 - Wart Vaccine, Killed Virus.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Wart Vaccine, Killed Virus. 113.206... AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.206 Wart Vaccine, Killed Virus. Wart Vaccine, Killed Virus, shall be...

  12. 9 CFR 113.206 - Wart Vaccine, Killed Virus.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Wart Vaccine, Killed Virus. 113.206... AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.206 Wart Vaccine, Killed Virus. Wart Vaccine, Killed Virus, shall be...

  13. 9 CFR 113.206 - Wart Vaccine, Killed Virus.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Wart Vaccine, Killed Virus. 113.206... AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.206 Wart Vaccine, Killed Virus. Wart Vaccine, Killed Virus, shall be...

  14. 75 FR 30299 - Drawbridge Operation Regulations; Newtown Creek, Dutch Kills, English Kills, and Their...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Newtown Creek, Dutch Kills, English Kills, and Their Tributaries, NY, Maintenance AGENCY: Coast Guard, DHS. ACTION: Notice of...

  15. 75 FR 62469 - Drawbridge Operation Regulations; Newtown Creek, Dutch Kills, English Kills, and Their...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Newtown Creek, Dutch Kills, English Kills, and Their Tributaries, NY, Maintenance AGENCY: Coast Guard, DHS. ACTION: Notice of...

  16. Strain ŽP - the first bacterial conjugation-based "kill"-"anti-kill" antimicrobial system.

    PubMed

    Starčič Erjavec, Marjanca; Petkovšek, Živa; Kuznetsova, Marina V; Maslennikova, Irina L; Žgur-Bertok, Darja

    2015-11-01

    As multidrug resistant bacteria pose one of the greatest risks to human health new alternative antibacterial agents are urgently needed. One possible mechanism that can be used as an alternative to traditional antibiotic therapy is transfer of killing agents via conjugation. Our work was aimed at providing a proof of principle that conjugation-based antimicrobial systems are possible. We constructed a bacterial conjugation-based "kill"-"anti-kill" antimicrobial system employing the well known Escherichia coli probiotic strain Nissle 1917 genetically modified to harbor a conjugative plasmid carrying the "kill" gene (colicin ColE7 activity gene) and a chromosomally encoded "anti-kill" gene (ColE7 immunity gene). The constructed strain acts as a donor in conjugal transfer and its efficiency was tested in several types of conjugal assays. Our results clearly demonstrate that conjugation-based antimicrobial systems can be highly efficient. PMID:26436830

  17. Extracellular killing of inhaled pneumococci in rats

    SciTech Connect

    Coonrod, J.D.; Marple, S.; Holmes, G.P.; Rehm, S.R.

    1987-12-01

    Early clearance of inhaled Staphylococcus aureus is believed to be caused by phagocytosis by alveolar macrophages. In murine models inhaled pneumococci are cleared even more rapidly than S. aureus. Conventional opsonins appear to play no role in this clearance, and recently it has been shown that murine alveolar lining material contains free fatty acids and other soluble factors that are directly bactericidal for pneumococci. To determine whether non-phagocytic factors are involved in pneumococcal clearance, we compared the site of killing of inhaled pneumococci and S. aureus in rats using histologic methods and bronchoalveolar lavage. Spontaneous lysis of pneumococci was prevented by use of autolysin-defective pneumococci or by substitution of ethanolamine for choline in the cell wall. Histologic studies showed that the percent of inhaled staphylococci associated with alveolar macrophages always exceeded the percent of staphylococci cleared, whereas there was little association of pneumococci with macrophages during clearance. Analysis of the intracellular or extracellular location of iron 59 in bronchoalveolar lavage fluid of rats that had inhaled aerosols of /sup 59/Fe-labeled bacteria suggested that staphylococci were killed predominantly in macrophages and pneumococci in the extracellular space. When /sup 59/Fe-labeled pneumococci or staphylococci were ingested and killed by macrophages in vitro, the /sup 59/Fe remained with the macrophages, suggesting that the extracellular location of /sup 59/Fe during pneumococcal killing in vivo was not caused by rapid turnover of /sup 59/Fe in macrophages. Studies of the site of killing of inhaled type 25 pneumococci labeled exclusively in the cell wall with carbon 14-ethanolamine confirmed the results obtained with /sup 59/Fe-labeled pneumococci. Thus, early killing of inhaled pneumococci, unlike staphylococci, appears to take place outside of macrophages.

  18. HIV transcription is induced with cell killing

    SciTech Connect

    Woloschak, G.E.; Schreck, S.; Chang-Liu, Chin-Mei; Panozzo, J.; Libertin, C.R.

    1993-11-01

    In this report, we demonstrate that this induction of HIV-LTR transcription occurs when stably transfected HeLa cells are exposed to agents which mediate cell killing, such as UV radiation, electroporation of sucrose buffer, prolonged heating, and low and high pH. Cells cultured following UV exposure demonstrated a peak in CAT expression that is evident in viable (but not necessarily cell division-competent) cells 24 h after exposure; this inductive response continued until at least 72 h after exposure. HIV-LTR induction was dose-dependent, and the amount of CAT transcription induced was correlated with the amount of cell killing that occurred in the culture.

  19. Cancer log-kill revisited.

    PubMed

    Norton, Larry

    2014-01-01

    At the root of science lie basic rules, if we can discover or deduce them. This is not an abstract project but practical; if we can understand the why then perhaps we can rationally intervene. One of the unifying unsolved problems in physics is the hypothetical "Theory of Everything." In a similar vein, we can ask whether our own field contains such hidden fundamental truths and, if so, how we can use them to develop better therapies and outcomes for our patients. Modern oncology has developed as drugs and translational science have matured over the 50 years since ASCO's founding, but almost from that beginning tumor modeling has been a key tool. Through this general approach Norton and Simon changed our understanding of cancer biology and response to therapy when they described the fit of Gompertzian curves to both clinical and animal observations of tumor growth. The practical relevance of these insights has only grown with the development of DNA sequencing promising a raft of new targets (and drugs). In that regard, Larry Norton's contribution to this year's Educational Book reminds us to always think creatively about the fundamental problems of tumor growth and metastases as well as therapeutic response. Demonstrating the creativity and thoughtfulness that have marked his remarkable career, he now incorporates a newer concept of self-seeding to further explain why Gompertzian growth occurs and, in the process, provides a novel potential therapeutic target. As you read his elegantly presented discussion, consider how this understanding, wisely applied to the modern era of targeted therapies, might speed the availability of better treatments. But even more instructive is his personal model-not only the Norton-Simon Hypothesis-of how to live and approach science, biology, patients and their families, as well as the broader community. He shows that with energy, enthusiasm, optimism, intellect, and hard work we can make the world better. Clifford A. Hudis, MD, FACP

  20. The evolution of reduced microbial killing.

    PubMed

    Vriezen, Jan A C; Valliere, Michael; Riley, Margaret A

    2009-01-01

    Bacteria engage in a never-ending arms race in which they compete for limited resources and niche space. The outcome of this intense interaction is the evolution of a powerful arsenal of biological weapons. Perhaps the most studied of these are colicins, plasmid-based toxins produced by and active against Escherichia coli. The present study was designed to explore the molecular responses of a colicin-producing strain during serial transfer evolution. What evolutionary changes occur when colicins are produced with no target present? Can killing ability be maintained in the absence of a target? To address these, and other, questions, colicinogenic strains and a noncolicinogenic ancestor were evolved for 253 generations. Samples were taken throughout the experiment and tested for killing ability. By the 38th transfer, a decreased killing ability and an increase in fitness were observed in the colicin-producing strains. Surprisingly, DNA sequence determination of the colicin plasmids revealed no changes in plasmid sequences. However, a set of chromosomally encoded loci experienced changes in gene expression that were positively associated with the reduction in killing. The most significant expression changes were observed in DNA repair genes (which were downregulated in the evolved strains), Mg ion uptake genes (which were upregulated), and late prophage genes (which were upregulated). These results indicate a fine-tuned response to the evolutionary pressures of colicin production, with far more genes involved than had been anticipated. PMID:20333208

  1. Can Vet Schools Teach without Killing Animals?

    ERIC Educational Resources Information Center

    Mangan, Katherine S.

    2000-01-01

    Discusses a protest by students at the University of Illinois (Urbana) College of Veterinary Medicine over the killing of animals that led to temporary curtailing of lethal animal experiments. Examines the conflict between animal rights groups and some faculty who are openly skeptical about the effectiveness of alternatives to the hands-on…

  2. Integrating Poetry and "To Kill a Mockingbird."

    ERIC Educational Resources Information Center

    Jolley, Susan Arpajian

    2002-01-01

    Outlines a method of teaching "To Kill a Mockingbird" along with the study of poetry. Notes that this method allows students to consider the themes of courage and developing compassion. Concludes that teaching such a multigenre unit allows students to look for connections among fact and fiction, the past and present, their own lives and…

  3. Peanut Roaster Temperatures Relative to Salmonella Kill

    Technology Transfer Automated Retrieval System (TEKTRAN)

    ARS, Market Quality and Handling Research Unit, Raleigh NC 27695 In response to the limited peanut butter contamination incident of 2006/7, studies were initiated to examine the effect of various time and temperature protocols on log kill levels for Salmonella on peanuts. The objective of the work ...

  4. MECHANISM BY WHICH AMMONIUM FERTILIZERS KILL LARKSPUR

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Environmental concerns of using pesticides on public lands have greatly reduced the use of herbicides to control tall larkspur (Delphinium barbeyi). Alternative methods of control have used ammonium sulfate placed in the crown of individual plants to kill larkspur. The objective of this study was ...

  5. Mass killings and detection of impacts

    NASA Technical Reports Server (NTRS)

    Mclaren, Digby J.

    1988-01-01

    Highly energetic bolide impacts occur and their flux is known. For larger bodies the energy release is greater than for any other short-term global phenomenon. Such impacts produce or release a large variety of shock induced changes including major atmospheric, sedimentologic, seismic and volcanic events. These events must necessarily leave a variety of records in the stratigraphic column, including mass killings resulting in major changes in population density and reduction or extinction of many taxonomic groups, followed by characteristic patterns of faunal and flora replacement. Of these effects, mass killings, marked by large-scale loss of biomass, are the most easily detected evidence in the field but must be manifest on a near-global scale. Such mass killings that appear to be approximately synchronous and involve disappearance of biomass at a bedding plane in many sedimentologically independent sections globally suggest a common cause and probable synchroneity. Mass killings identify an horizon which may be examined for evidence of cause. Geochemical markers may be ephemeral and absence may not be significant. There appears to be no reason why ongoing phenomena such as climate and sea-level changes are primary causes of anomolous episodic events.

  6. Killing Hitler: A Writer's Journey and Angst.

    ERIC Educational Resources Information Center

    Thaler, Paul

    2002-01-01

    Describes the author's experiences in preparing a talk that "evokes the specter" of Adolf Hitler and in writing an historical account of a British plot to kill Hitler. Address the question of why the British allowed him to live that final year of the war. Muses on why scholars write, and the impact of violence and terrorism. (SG)

  7. Nonlinear symmetries on spaces admitting Killing tensors

    NASA Astrophysics Data System (ADS)

    Visinescu, Mihai

    2010-04-01

    Nonlinear symmetries corresponding to Killing tensors are investigated. The intimate relation between Killing-Yano tensors and non-standard supersymmetries is pointed out. The gravitational anomalies are absent if the hidden symmetry is associated with a Killing-Yano tensor. In the case of the nonlinear symmetries the dynamical algebras of the Dirac-type operators is more involved and could be organized as infinite dimensional algebras or superalgebras. The general results are applied to some concrete spaces involved in theories of modern physics. As a first example it is considered the 4-dimensional Euclidean Taub-NUT space and its generalizations introduced by Iwai and Katayama. One presents the infinite dimensional superalgebra of Dirac type operators on Taub-NUT space that could be seen as a graded loop superalgebra of the Kac-Moody type. The axial anomaly, interpreted as the index of the Dirac operator, is computed for the generalized Taub-NUT metrics. Finally the existence of the conformal Killing-Yano tensors is investigated for some spaces with mixed Sasakian structures.

  8. Why Did August Strindberg Not Kill Himself?

    ERIC Educational Resources Information Center

    Shulman, Ernest

    1993-01-01

    Discusses approach examining why individual did not kill himself when he could have been expected to do so. Uses approach to examine nonsuicide of Swedish playwright August Strindberg. Focuses on disjunction between Strindberg's early and later life, specifically on factors that enabled him to recover from psychotic episodes with suicidal…

  9. School Shootings; Standards Kill Students and Society

    ERIC Educational Resources Information Center

    Angert, Betsy L.

    2008-01-01

    School shootings have been in the news of late. People ponder what occurs in classrooms today. Why would a young person wish to take a life? Within educational institutions, the killings are a concern. In our dire attempt to teach the children and ensure student success, it seems many of our offspring are lost. Some students feel separate from…

  10. Contagion in Mass Killings and School Shootings

    PubMed Central

    Towers, Sherry; Gomez-Lievano, Andres; Khan, Maryam; Mubayi, Anuj; Castillo-Chavez, Carlos

    2015-01-01

    Background Several past studies have found that media reports of suicides and homicides appear to subsequently increase the incidence of similar events in the community, apparently due to the coverage planting the seeds of ideation in at-risk individuals to commit similar acts. Methods Here we explore whether or not contagion is evident in more high-profile incidents, such as school shootings and mass killings (incidents with four or more people killed). We fit a contagion model to recent data sets related to such incidents in the US, with terms that take into account the fact that a school shooting or mass murder may temporarily increase the probability of a similar event in the immediate future, by assuming an exponential decay in contagiousness after an event. Conclusions We find significant evidence that mass killings involving firearms are incented by similar events in the immediate past. On average, this temporary increase in probability lasts 13 days, and each incident incites at least 0.30 new incidents (p = 0.0015). We also find significant evidence of contagion in school shootings, for which an incident is contagious for an average of 13 days, and incites an average of at least 0.22 new incidents (p = 0.0001). All p-values are assessed based on a likelihood ratio test comparing the likelihood of a contagion model to that of a null model with no contagion. On average, mass killings involving firearms occur approximately every two weeks in the US, while school shootings occur on average monthly. We find that state prevalence of firearm ownership is significantly associated with the state incidence of mass killings with firearms, school shootings, and mass shootings. PMID:26135941

  11. 75 FR 63453 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-15

    ... on Wednesday, October 27, 2010. Docket Numbers: ER10-2783-001. Applicants: Arthur Kill Power LLC. Description: Arthur Kill Power LLC submits tariff filing per 35: Arthur Kill--Amendment to Market-Based...

  12. Killing spinors and related symmetries in six dimensions

    NASA Astrophysics Data System (ADS)

    Batista, Carlos

    2016-03-01

    Benefiting from the index spinorial formalism, the Killing spinor equation is integrated in six-dimensional spacetimes. The integrability conditions for the existence of a Killing spinor are worked out and the Killing spinors are classified into two algebraic types; in the first type the scalar curvature of the spacetime must be negative, while in the second type the spacetime must be an Einstein manifold. In addition, the equations that define Killing-Yano (KY) and closed conformal Killing-Yano (CCKY) tensors are expressed in the index notation and, as consequence, all nonvanishing KY and CCKY tensors that can be generated from a Killing spinor are made explicit.

  13. Historical perspective: Arthur Kornberg, a giant of 20th century biochemistry.

    PubMed

    Lehman, I Robert

    2008-06-01

    For physics, the period from the beginning to the middle of the 20th century was one of great scientific excitement and revolutionary discovery. The analogous era for biochemistry, and its offspring, molecular biology, was the second half of the 20th century. One of the most important and influential leaders of this scientific revolution was Arthur Kornberg. The DNA polymerase, which he discovered in 1955 and showed to have the remarkable capacity to catalyze the template-directed synthesis of DNA, contributed in major ways to the present-day understanding of how DNA is replicated and repaired, and how it is transcribed. The discovery of DNA polymerase also permitted the development of PCR and DNA sequencing, upon which much of modern biotechnology is based. Kornberg's studies of DNA replication, which spanned a period of nearly 30 years, culminated in a detailed biochemical description of the mechanism by which a chromosome is replicated. The final years of Kornberg's life were devoted to the study of polyphosphate, which he was convinced had a crucial role in cellular function. PMID:18467101

  14. Bathymetric Surveys of Lake Arthur and Raccoon Lake, Pennsylvania, June 2007

    USGS Publications Warehouse

    Hittle, Clinton D.; Ruby, A. Thomas, III

    2008-01-01

    In spring of 2007, bathymetric surveys of two Pennsylvania State Park lakes were performed to collect accurate data sets of lake-bed elevations and to develop methods and techniques to conduct similar surveys across the state. The lake-bed elevations and associated geographical position data can be merged with land-surface elevations acquired through Light Detection and Ranging (LIDAR) techniques. Lake Arthur in Butler County and Raccoon Lake in Beaver County were selected for this initial data-collection activity. In order to establish accurate water-surface elevations during the surveys, benchmarks referenced to NAVD 88 were established on land at each lake by use of differential global positioning system (DGPS) surveys. Bathymetric data were collected using a single beam, 210 kilohertz (kHz) echo sounder and were coupled with the DGPS position data utilizing a computer software package. Transects of depth data were acquired at predetermined intervals on each lake, and the shoreline was delineated using a laser range finder and compass module. Final X, Y, Z coordinates of the geographic positions and lake-bed elevations were referenced to NAD 83 and NAVD 88 and are available to create bathymetric maps of the lakes.

  15. Hurricane Arthur and its effect on the short term variation of pCO2

    NASA Astrophysics Data System (ADS)

    Lemay, Jonathan; Thomas, Helmuth; Craig, Susanne; Greenan, Blair; Fennel, Katja

    2016-04-01

    Seasonal changes in carbon cycling over the years have become better understood on the Scotian Shelf, however little is resolved in short term variation. Hourly measurements were collected from an autonomous moored instrument (CARIOCA) stationed at Halifax Line 2 (HL2), roughly 30km off the coast of Halifax for the 2014 year. Data from the 2007 deployment of the SeaHorse vertical sampling mooring at HL2 was also collected. Focusing on the storm event, Hurricane Arthur, July 5th 2014 reveals a significant drop in pCO2. With the shelf having carbon rich deep water, a reduction of pCO2 due to mixing went against current understanding. It was revealed that slightly above the mixed layer there is a sustained population of phytoplankton. When wind mixing from storms occurs, this population moves to the surface allowing greater light and nutrients for short term growth. This growth then reduces pCO2 for a short period of time until wind speeds slow down reducing mixing of the water column.

  16. Conformal killing tensors and covariant Hamiltonian dynamics

    SciTech Connect

    Cariglia, M.; Gibbons, G. W.; Holten, J.-W. van; Horvathy, P. A.; Zhang, P.-M.

    2014-12-15

    A covariant algorithm for deriving the conserved quantities for natural Hamiltonian systems is combined with the non-relativistic framework of Eisenhart, and of Duval, in which the classical trajectories arise as geodesics in a higher dimensional space-time, realized by Brinkmann manifolds. Conserved quantities which are polynomial in the momenta can be built using time-dependent conformal Killing tensors with flux. The latter are associated with terms proportional to the Hamiltonian in the lower dimensional theory and with spectrum generating algebras for higher dimensional quantities of order 1 and 2 in the momenta. Illustrations of the general theory include the Runge-Lenz vector for planetary motion with a time-dependent gravitational constant G(t), motion in a time-dependent electromagnetic field of a certain form, quantum dots, the Hénon-Heiles and Holt systems, respectively, providing us with Killing tensors of rank that ranges from one to six.

  17. 11. GENERAL INTERIOR VIEW OF KILLING FLOOR ON LEVEL 4; ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. GENERAL INTERIOR VIEW OF KILLING FLOOR ON LEVEL 4; LOOKING SOUTHWEST TOWARD SPLITTERS' PLATFORMS - Rath Packing Company, Beef Killing Building, Sycamore Street between Elm & Eighteenth Streets, Waterloo, Black Hawk County, IA

  18. A mass killing in New Zealand.

    PubMed

    Brinded, P M; Taylor, A J

    1995-06-01

    The circumstances surrounding a mass killing in New Zealand are described in conjunction with a review of a number of other similar multiple victim homicides. Due to the rare and extreme nature of such events, it is argued that they should be managed as human disasters by the professionals involved and that stress debriefing should be available for all potential primary, secondary and tertiary victims. PMID:7487798

  19. Project Probes Digital Media's Effect on Ethics: Howard Gardner Leads Team Studying Youths' Web Norms

    ERIC Educational Resources Information Center

    Viadero, Debra

    2008-01-01

    Noted Harvard psychologist Howard Gardner is leading a team studying the social and ethical norms of young people on the Web. Known as the "GoodPlay Project," the study is being financed with a grant from the Chicago-based Catherine T. MacArthur Foundation. What researchers hope to do through the project is fill a gap in the burgeoning research…

  20. 77 FR 18885 - Improving Performance of Federal Permitting and Review of Infrastructure Projects

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-28

    ..., employees, or agents, or any other person. (Presidential Sig.) THE WHITE HOUSE, March 22, 2012. [FR Doc... and Review of Infrastructure Projects Memorandum of March 22, 2012--Expediting Review of Pipeline Projects From Cushing, Oklahoma, to Port Arthur, Texas, and Other Domestic Pipeline Infrastructure...

  1. HIV transcription is induced with cell killing

    SciTech Connect

    Woloschak, G.E.; Schreck, S.; Chang-Liu, Chin Mei; Panozzo, J.; Libertin, C.R.

    1994-01-01

    Previous work has shown that HeLa cells stably transfected with an HIV-LTR-CAT construct are induced to express chloramphenicol acetyl transferase (CAT) following exposure to DNA-damaging agents such as ultraviolet radiation, {gamma} rays, neutrons, and others. In this report, the authors demonstrate that this induction of HIV-LTR transcription occurs when stably transfected HeLa cells are exposed to agents which mediate cell killing, such as UV radiation, electroporation of sucrose buffer, prolonged heating, and low and high pH. Cells cultured following UV exposure demonstrated a peak in CAT expression that is evidence in viable (but not necessarily cell division-competent) cells 24 h after exposure; this inductive response continued until at least 72 h after exposure. HIV-LTR induction was dose-dependent, and the amount of CAT transcription induced was correlated with the amount of cell killing that occurred in the culture. Other agents which caused no cell killing (such as heat-shock for up to 2 h, treatment with metronidazole, exposure to sunlight, vitamin C treatment, and others) had no effect on HIV-LTR induction. These results suggest that HIV transcription is induced as a consequence of the turn on of a cellular death or apoptotic pathway.

  2. Road-Killed Animals as Resources for Ecological Studies.

    ERIC Educational Resources Information Center

    Adams, Clark E.

    1983-01-01

    Summarizes 19 literature sources identifying road-killed vertebrates and frequency of kill by numbers. Examples of how these animals can be incorporated into curricula (integrating biology, society, people, and values) are given, followed by an illustrated example of how a road-killed raccoon's skull demonstrated a human/wildlife interaction prior…

  3. 9 CFR 113.204 - Mink Enteritis Vaccine, Killed Virus.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Mink Enteritis Vaccine, Killed Virus..., DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.204 Mink Enteritis Vaccine, Killed Virus. Mink Enteritis...

  4. 9 CFR 113.212 - Bursal Disease Vaccine, Killed Virus.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Bursal Disease Vaccine, Killed Virus..., DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.212 Bursal Disease Vaccine, Killed Virus. Bursal Disease...

  5. 9 CFR 113.212 - Bursal Disease Vaccine, Killed Virus.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Bursal Disease Vaccine, Killed Virus..., DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.212 Bursal Disease Vaccine, Killed Virus. Bursal Disease...

  6. 9 CFR 113.208 - Avian Encephalomyelitis Vaccine, Killed Virus.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., Killed Virus. 113.208 Section 113.208 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.208 Avian Encephalomyelitis Vaccine, Killed Virus....

  7. 9 CFR 113.208 - Avian Encephalomyelitis Vaccine, Killed Virus.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., Killed Virus. 113.208 Section 113.208 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.208 Avian Encephalomyelitis Vaccine, Killed Virus....

  8. 9 CFR 113.208 - Avian Encephalomyelitis Vaccine, Killed Virus.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., Killed Virus. 113.208 Section 113.208 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.208 Avian Encephalomyelitis Vaccine, Killed Virus....

  9. 9 CFR 113.204 - Mink Enteritis Vaccine, Killed Virus.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Mink Enteritis Vaccine, Killed Virus..., DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.204 Mink Enteritis Vaccine, Killed Virus. Mink Enteritis...

  10. 9 CFR 113.212 - Bursal Disease Vaccine, Killed Virus.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Bursal Disease Vaccine, Killed Virus..., DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.212 Bursal Disease Vaccine, Killed Virus. Bursal Disease...

  11. 9 CFR 113.204 - Mink Enteritis Vaccine, Killed Virus.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Mink Enteritis Vaccine, Killed Virus..., DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.204 Mink Enteritis Vaccine, Killed Virus. Mink Enteritis...

  12. 9 CFR 113.204 - Mink Enteritis Vaccine, Killed Virus.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Mink Enteritis Vaccine, Killed Virus..., DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.204 Mink Enteritis Vaccine, Killed Virus. Mink Enteritis...

  13. 9 CFR 113.212 - Bursal Disease Vaccine, Killed Virus.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Bursal Disease Vaccine, Killed Virus..., DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.212 Bursal Disease Vaccine, Killed Virus. Bursal Disease...

  14. 9 CFR 113.212 - Bursal Disease Vaccine, Killed Virus.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Bursal Disease Vaccine, Killed Virus..., DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.212 Bursal Disease Vaccine, Killed Virus. Bursal Disease...

  15. 9 CFR 113.204 - Mink Enteritis Vaccine, Killed Virus.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Mink Enteritis Vaccine, Killed Virus..., DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.204 Mink Enteritis Vaccine, Killed Virus. Mink Enteritis...

  16. 9 CFR 113.208 - Avian Encephalomyelitis Vaccine, Killed Virus.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., Killed Virus. 113.208 Section 113.208 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.208 Avian Encephalomyelitis Vaccine, Killed Virus....

  17. 9 CFR 113.208 - Avian Encephalomyelitis Vaccine, Killed Virus.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., Killed Virus. 113.208 Section 113.208 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.208 Avian Encephalomyelitis Vaccine, Killed Virus....

  18. Integrated Solid Earth Science: the right place and time to discover the unexpected? (Arthur Holmes Medal Lecture)

    NASA Astrophysics Data System (ADS)

    Cloetingh, Sierd

    2013-04-01

    The fascination of learning more about the way system Earth operates has driven generations of Earth scientists. This has been the case for early pioneers such as Arthur Holmes, focusing on the geological record in continental settings, as well as for the founding fathers of plate tectonics, who built upon the results of exploring the ocean floor. Two years ago we celebrated the centenary of the discovery by Mohorovicic of the seismic discontinuity that separates the crust from the mantle, which now carries his name. Reading the rocks and mapping the (sub)surface of the Earth has provided the foundation for a great deal of what we conceptually pursue today in developing and validating coupled deep Earth and surface processes. The unexpected is probably characterizing most of my scientific career. It started in 1968 when, as a student, entering the geology program of Groningen University headed by Professor Philip Kuenen, a pioneer in marine geology and sedimentology, the textbook of Arthur Holmes just happened to be my first purchase. It was during those years that plate tectonics drastically changed everything we were learning. I was also privileged to enter a few years later as an MSc student the Utrecht geophysics school at a time where Nico Vlaar as a young professor was developing a vigorous research program with a focus on seismology, attracting and stimulating many talented students. When he and Rinus Wortel started research on Tectonophysics in Utrecht, I decided to go for a PhD research project tackling the problem of the initiation of subduction, a first order problem in geodynamics, with still many aspects to be resolved. This research and the joint work with Rinus Wortel on modeling intraplate stresses in the Faralon, Nazca and Indo-Australian plates led quite unexpectedly to exploring, together with Kurt Lambeck, intraplate stress fluctuations in the lithosphere as possible tectonic causes for the origin of third-order cycles in relative sea

  19. War neuroses and Arthur Hurst: a pioneering medical film about the treatment of psychiatric battle casualties.

    PubMed

    Jones, Edgar

    2012-07-01

    From 1917 to 1918, Major Arthur Hurst filmed shell-shocked patients home from the war in France. Funded by the Medical Research Committee, and using Pathé cameramen, he recorded soldiers who suffered from intractable movement disorders as they underwent treatment at the Royal Victoria Hospital in Netley and undertook programs of occupational therapy at Seale Hayne in Devon. As one of the earliest UK medical films, Hurst's efforts may have drawn inspiration from the official documentary of the Battle of the Somme and films made in 1916 by French Army neurologists. Although initially motivated to make use of a novel medium to illustrate lectures, Hurst was alert to the wider appeal of the motion picture and saw an opportunity to position himself in the postwar medical hierarchy. Some "before treatment" shots were reenacted for the camera. Hurst, like some other shell shock doctors, openly used deception as a therapeutic measure. On the basis that the ends justified the means, they defended this procedure as ethical. Clinicians also took advantage of changes in military regulations to address functional symptoms. Claims made of "cures" in the film and associated publications by Hurst were challenged by other doctors treating shell shock. The absence of follow-up data and evidence from war pension files suggested that Hurst may have overstated the effectiveness of his methods. Nevertheless, the message conveyed in the film that chronic cases could be treated in a single session had a powerful resonance for ambitious or charismatic doctors and was revived in World War II. PMID:21596724

  20. Phantoms in artists: the lost limbs of Blaise Cendrars,Arthur Rimbaud, and Paul Wittgenstein.

    PubMed

    Tatu, Laurent; Bogousslavsky, Julien; Boller, François

    2014-01-01

    There have been an increasing number of reports of postamputation pain and problems linked to phantom limbs over recent years, particularly in relation to war-related amputations. These problems, which are often poorly understood and considered rather mysterious, are still relevant because they are difficult to treat medically. Functional neuroimaging techniques now enable us to better understand their pathophysiology and to consider new rehabilitation techniques. Phantom limbs have often been a source of inspiration to writers, particularly in the period following the First World War, which was responsible for thousands of amputees. Some artists have suffered from postamputation complications themselves and have expressed them through their artistic works. Blaise Cendrars (1887-1961), one of the greatest authors of the twentieth century, suffered from stump pain and phantom limb phenomena for almost half a century following the amputation of his right arm during the First World War. He suffered from these phenomena until the end of his life and his literary work and personal correspondence are peppered with references to them. Arthur Rimbaud (1854-1891), one of the most famous poets in world literature, developed severe stump pain after his right leg was amputated due to a tumor. He survived for only six months after the procedure but left behind an account of the pain he experienced in correspondence to his family. The famous pianist Paul Wittgenstein (1887-1961), whose right arm was amputated during the First World War, became a famous left-handed concert pianist. The phantom movements of his right hand helped him to develop the dexterity of his left hand. The impact on the artistic life of these three men provides an original illustration of the various postamputation complications, specifically phantom limbs, stump pain, and moving phantom. PMID:24956238

  1. Noether versus Killing symmetry of conformally flat Friedmann metric

    NASA Astrophysics Data System (ADS)

    Bokhari, Ashfaque H.; Kara, A. H.

    2007-12-01

    In a recent study Noether symmetries of some static spacetime metrics in comparison with Killing vectors of corresponding spacetimes were studied. It was shown that Noether symmetries provide additional conservation laws that are not given by Killing vectors. In an attempt to understand how Noether symmetries compare with conformal Killing vectors, we find the Noether symmetries of the flat Friedmann cosmological model. We show that the conformally transformed flat Friedman model admits additional conservation laws not given by the Killing or conformal Killing vectors. Inter alia, these additional conserved quantities provide a mechanism to twice reduce the geodesic equations via the associated Noether symmetries.

  2. Dynamic kill: controlling wild wells a new way

    SciTech Connect

    Blount, E.M.; Soeiinah, E.

    1981-10-01

    Dynamic kill describes a technique for terminating a blowout utilizing flowing frictional pressure to supplement the hydrostatic pressure of the kill fluid being injected through the relief well and up the blowing well. Therefore, a lighter kill fluid such as water can be implemented. The objective is to allow a blowout to be killed without breaking down the formation so the maximum amount of fluid can be circulated through the relief well by not losing fluid to a fractured formation. This allows optimum control during the kill operation and stable communication between the two wells. By allowing more fluid to be applied to the kill through one relief well, dynamic kill also increases the probability that one relief well will be sufficient. When the well is dynamically dead, the initial kill fluid, which will usually be too light to hold the well dead in a static condition, is replaced with a heavier kill mud. In fact, three weights of mud may be required to allow control during the transition from low density initial dynamic kill mud to heavy final kill mud. 5 refs.

  3. Killing-Yano forms and Killing tensors on a warped space

    NASA Astrophysics Data System (ADS)

    Krtouš, Pavel; KubizÅák, David; Kolář, Ivan

    2016-01-01

    We formulate several criteria under which the symmetries associated with the Killing and Killing-Yano tensors on the base space can be lifted to the symmetries of the full warped geometry. The procedure is explicitly illustrated on several examples, providing new prototypes of spacetimes admitting such tensors. In particular, we study a warped product of two Kerr-NUT-(A)dS spacetimes and show that it gives rise to a new class of highly symmetric vacuum (with a cosmological constant) black hole solutions that inherit many of the properties of the Kerr-NUT-(A)dS geometry.

  4. Progress at Fresh Kills improving water quality

    SciTech Connect

    Londres, E.J.

    1991-06-01

    This paper reports that in December 1987, the federal district court in Nevada issued a consent order forcing New York City (NYC) to improve its handling of solid waste and reduce the discharge of solid waste into the surrounding waterway. Implementation of the consent order by NYC resulted in many improvements in the transport of solid waste from the Marine Transfer Station (MTS) to Fresh Kills Landfill. The end result was a marked reduction in solid waste discharge and an improvement in water quality along the New Jersey shore areas.

  5. Targeting the Checkpoint to Kill Cancer Cells

    PubMed Central

    Benada, Jan; Macurek, Libor

    2015-01-01

    Cancer treatments such as radiotherapy and most of the chemotherapies act by damaging DNA of cancer cells. Upon DNA damage, cells stop proliferation at cell cycle checkpoints, which provides them time for DNA repair. Inhibiting the checkpoint allows entry to mitosis despite the presence of DNA damage and can lead to cell death. Importantly, as cancer cells exhibit increased levels of endogenous DNA damage due to an excessive replication stress, inhibiting the checkpoint kinases alone could act as a directed anti-cancer therapy. Here, we review the current status of inhibitors targeted towards the checkpoint effectors and discuss mechanisms of their actions in killing of cancer cells. PMID:26295265

  6. Bacterial Killing by Dry Metallic Copper Surfaces▿

    PubMed Central

    Santo, Christophe Espírito; Lam, Ee Wen; Elowsky, Christian G.; Quaranta, Davide; Domaille, Dylan W.; Chang, Christopher J.; Grass, Gregor

    2011-01-01

    Metallic copper surfaces rapidly and efficiently kill bacteria. Cells exposed to copper surfaces accumulated large amounts of copper ions, and this copper uptake was faster from dry copper than from moist copper. Cells suffered extensive membrane damage within minutes of exposure to dry copper. Further, cells removed from copper showed loss of cell integrity. Acute contact with metallic copper surfaces did not result in increased mutation rates or DNA lesions. These findings are important first steps for revealing the molecular sensitive targets in cells lethally challenged by exposure to copper surfaces and provide a scientific explanation for the use of copper surfaces as antimicrobial agents for supporting public hygiene. PMID:21148701

  7. The killing efficiency of soft iron shot

    USGS Publications Warehouse

    Andrews, R.; Longcore, J.R.

    1969-01-01

    A cooperative research effort between the ammunition industry and the Bureau of Sport Fisheries and Wildlife is aimed at finding a suitable non-toxic substitute for lead shot. A contract study by an independent research organization evaluated ways of coating or detoxifying lead shot or replacing it with another metal. As a result of that study, the only promising candidate is soft iron. Previous tests of hard iron shot had suggested that its killing effectiveness was poor at longer ranges due to the lower density. In addition, its hardness caused excessive damage to shotgun barrels. A unique, automated shooting facility was constructed at the Patuxent Wildlife Research Center to test the killing effectiveness of soft iron shot under controlled conditions. Tethered game-farm mallards were transported across a shooting point in a manner simulating free flight. A microswitch triggered a mounted shotgun so that each shot was 'perfect.' A soft iron shot, in Number 4 size, was produced by the ammunition industry and loaded in 12-gauge shells to give optimum ballistic performance. Commercial loads of lead shot in both Number 4 and Number 6 size were used for comparison. A total of 2,010 ducks were shot at ranges of 30 to 65 yards and at broadside and head-on angles in a statistically designed procedure. The following data were recorded for each duck: time until death, broken wing or leg bones, and number of embedded shot. Those ducks not killed outright were held for 10 days. From these data, ducks were categorized as 'probably bagged,' 'probably lost cripples,' or survivors. The test revealed that the killing effectiveness of this soft iron shot was superior to its anticipated performance and close to that obtained with commercial lead loads containing an equal number of pellets. Bagging a duck, in terms of rapid death or broken wing, was primarily dependent on the probability of a shot striking that vital area, and therefore a function of range. There was no indication

  8. Dr Arthur Wakefield on Mount Everest in 1922: "this has not been by any manner of means a picnic".

    PubMed

    Bayne, Ronald

    2003-08-01

    In 1922 Dr Arthur Wakefield, a general practitioner from Cumbria, reached the North Col of Mt Everest at 23,000 feet as a member of the first British team to attempt the summit. As well as being a climber, he provided medical care to his comrades, who included George Leigh Mallory and George Finch. Yet, in their accounts of the expedition, several climbers portrayed him as a nervous old man and a "complete passenger". However, his letters home and a small daily diary suggest he was a wise and caring physician. His motivation for joining this expedition at the age of 46 was somewhat different from that of his companions. PMID:12870039

  9. The ability of insect-killing fungi to kill pecan aphids under laboratory conditions

    Technology Transfer Automated Retrieval System (TEKTRAN)

    There is need for efficacious biocontrol agents for pecan aphids in commercial orchards. We determined the virulence (killing power) of several beneficial fungi to pecan aphids. We tested three species (kinds) of fungi: 1) Isaria fumosorosea (two strains of this species were tested: ARSEF 3581 a...

  10. Heterosigma bloom and associated fish kill

    USGS Publications Warehouse

    Hershberger, P.K.; Rensel, J.E.; Postel, J.R.; Taub, F.B.

    1997-01-01

    A bloom of the harmful marine phytoplankton, Heterosigma carterae occurred in upper Case Inlet, south Puget Sound, Washington in late September, 1994, correlating with the presence of at least 35 dead salmon. This marks the first time that this alga has been closely correlated with a wild fish kill; in the past it was thought to be associated with kills of penned fish at fish farms only. We were informed of the presence of a possible harmful algal bloom and dead salinois Ilear the town of Allyn on 27 September and a team was formed to investigate. We arrived at the Allyn waterfront at 17:30 hours the same day. Prior to our arrival, state agency personnel walked approximatcly two miles of shoreline from the powerlines north of the dock, to the mouth of Sherwood Creek and conducted the only official count of dead fish present along the shore consisting of 12 coho salmon (Oncorhynchus kisutch), 11 chum salmon (Oncorhynchus keta), 12 chinook salmon (Oncorhynchus tschawytscha), one flat fish, and one sculpin on the morning of 9/27. Since previous harmful blooms of Heterosigma have resultedin the majority of net penreared salmon sinking to the bottom of pens, and only approximately two miles of shoreline were sampled, it is suspected that many more exposed fish may have succumbed than were counted. Witnesses who explored the east side of the bay reported seeing many dead salmon there as well, but no counts were made. State agency personnel who observed the fish kill reported seeing “dying fish coming to the beach, gulping at the surface, trying to get out of the water” Scavengers were seen consuming the salmon carcasses; these included two harbor seals, a house cat, and Hymenopteran insects. None suffered any noticeable acute ill effects. Although precise cause of death has not been ascertained, visual inspection of the reproductive organs from a deceased male chum salmon found on the shore at Allyn confirmed that the fish was not yet reproductively mature and

  11. Using Chemoattractants to Lure Bacteria to Contact-Killing Surfaces.

    PubMed

    Jain, Rishabh; Faith, Nancy G; Milkowski, Andrew; Nelson, Kevin; Busche, David; Lynn, David M; Czuprynski, Charles J; Abbott, Nicholas L

    2016-05-01

    Antimicrobial surfaces with covalently attached biocidal functionalities only kill microbes that come into direct contact with the surfaces (contact-killing surfaces). Herein, the activity of contact-killing surfaces is shown to be enhanced by using gradients in the concentration of soluble chemoattractants (CAs) to attract bacteria to the surfaces. Two natural and nonbiocidal CAs (aspartate and glucose) were used to attract bacteria to model surfaces decorated with quaternary ammonium groups (known to kill bacteria that come into contact with them). These results demonstrate the killing of Escherichia coli and Salmonella typhimurium, two common pathogens, at levels 10- to 20-times greater than that of the native surfaces alone. This approach is general and provides new strategies for the design of active or dynamic contact-killing surfaces with enhanced antimicrobial activities. PMID:27059788

  12. The eyeball killer: serial killings with postmortem globe enucleation.

    PubMed

    Coyle, Julie; Ross, Karen F; Barnard, Jeffrey J; Peacock, Elizabeth; Linch, Charles A; Prahlow, Joseph A

    2015-05-01

    Although serial killings are relatively rare, they can be the cause of a great deal of anxiety while the killer remains at-large. Despite the fact that the motivations for serial killings are typically quite complex, the psychological analysis of a serial killer can provide valuable insight into how and why certain individuals become serial killers. Such knowledge may be instrumental in preventing future serial killings or in solving ongoing cases. In certain serial killings, the various incidents have a variety of similar features. Identification of similarities between separate homicidal incidents is necessary to recognize that a serial killer may be actively killing. In this report, the authors present a group of serial killings involving three prostitutes who were shot to death over a 3-month period. Scene and autopsy findings, including the unusual finding of postmortem enucleation of the eyes, led investigators to recognize the serial nature of the homicides. PMID:25682709

  13. f(R)-gravity from Killing tensors

    NASA Astrophysics Data System (ADS)

    Paliathanasis, Andronikos

    2016-04-01

    We consider f(R)-gravity in a Friedmann-Lemaître-Robertson-Walker spacetime with zero spatial curvature. We apply the Killing tensors of the minisuperspace in order to specify the functional form of f(R) and for the field equations to be invariant under Lie-Bäcklund transformations, which are linear in momentum (contact symmetries). Consequently, the field equations to admit quadratic conservation laws given by Noether’s theorem. We find three new integrable f(R)-models, for which, with the application of the conservation laws, we reduce the field equations to a system of two first-order ordinary differential equations. For each model we study the evolution of the cosmological fluid. We find that for each integrable model the cosmological fluid has an equation of state parameter, in which there is linear behavior in terms of the scale factor which describes the Chevallier, Polarski and Linder parametric dark energy model.

  14. Heat production due to intracellular killing activity.

    PubMed

    Hayatsu, H; Masuda, S; Miyamae, T; Yamamura, M

    1990-09-01

    Using Saccharomyces ceravisiae, Candida albicans and Stapylococcus aureus, heat production during phagocytosis was measured in U937 cells which are capable of differentiating to monocytic phagocytes. No increase in heat production of non-differentiated U937 was observed since they were not phagocytic cells. However after differentiation to monocytic phagocytes by lymphokine, U937 cells produced a remarkable amount of heat during phagocytosis. Although Ehrlich ascites tumor cells sensitized with antibody were capable of engulfing S. aureus, no increase in heat nor in superoxide anion production during phagocytosis was detected. It was also found that no heat increase occurred in neutrophils from a patient with chronic granulomatous disease (CGD). It can thus be concluded that the heat production during phagocytosis is due to the intercellular killing process of phagocytic cells. PMID:2131646

  15. Advanced gel propulsion controls for kill vehicles

    NASA Astrophysics Data System (ADS)

    Yasuhara, W. K.; Olson, A.; Finato, S.

    1993-06-01

    A gel propulsion control concept for tactical applications is reviewed, and the status of the individual component technologies currently under development at the Aerojet Propulsion Division is discussed. It is concluded that a gel propellant Divert and Attitude Control Subsystem (DACS) provides a safe, insensitive munitions compliant alternative to current liquid Theater Missile Defense (TMD) DACS approaches. The gel kill vehicle (KV) control system packages a total impulse typical of a tactical weapon interceptor for the ground- or sea-based TMD systems. High density packaging makes it possible to increase firepower and to eliminate long-term high pressure gas storage associated with bipropellant systems. The integrated control subsystem technologies encompass solid propellant gas generators, insulated composite overwrapped propellant tanks, lightweight endoatmospheric thrusters, and insensitive munition gel propellants, which meet the requirements of a deployable, operationally safe KV.

  16. Advancements in dynamic kill calculations for blowout wells

    SciTech Connect

    Kouba, G.E. . Production Fluids Div.); MacDougall, G.R. ); Schumacher, B.W. . Information Technology Dept.)

    1993-09-01

    This paper addresses the development, interpretation, and use of dynamic kill equations. To this end, three simple calculation techniques are developed for determining the minimum dynamic kill rate. Two techniques contain only single-phase calculations and are independent of reservoir inflow performance. Despite these limitations, these two methods are useful for bracketing the minimum flow rates necessary to kill a blowing well. For the third technique, a simplified mechanistic multiphase-flow model is used to determine a most-probable minimum kill rate.

  17. Antibacterial activity of silver-killed bacteria: the "zombies" effect

    NASA Astrophysics Data System (ADS)

    Wakshlak, Racheli Ben-Knaz; Pedahzur, Rami; Avnir, David

    2015-04-01

    We report a previously unrecognized mechanism for the prolonged action of biocidal agents, which we denote as the zombies effect: biocidally-killed bacteria are capable of killing living bacteria. The concept is demonstrated by first killing Pseudomonas aeruginosa PAO1 with silver nitrate and then challenging, with the dead bacteria, a viable culture of the same bacterium: Efficient antibacterial activity of the killed bacteria is observed. A mechanism is suggested in terms of the action of the dead bacteria as a reservoir of silver, which, due to Le-Chatelier's principle, is re-targeted to the living bacteria. Langmuirian behavior, as well as deviations from it, support the proposed mechanism.

  18. Killing spinors as a characterisation of rotating black hole spacetimes

    NASA Astrophysics Data System (ADS)

    Cole, Michael J.; Valiente Kroon, Juan A.

    2016-06-01

    We investigate the implications of the existence of Killing spinors in a spacetime. In particular, we show that in vacuum and electrovacuum a Killing spinor, along with some assumptions on the associated Killing vector in an asymptotic region, guarantees that the spacetime is locally isometric to the Kerr or Kerr–Newman solutions. We show that the characterisation of these spacetimes in terms of Killing spinors is an alternative expression of characterisation results of Mars (Kerr) and Wong (Kerr–Newman) involving restrictions on the Weyl curvature and matter content.

  19. Generalized Taub-NUT metrics and Killing-Yano tensors

    NASA Astrophysics Data System (ADS)

    Visinescu, Mihai

    2000-06-01

    The necessary condition that a Stäckel-Killing tensor of valence two should be the contracted product of a Killing-Yano tensor of valence two with itself is rederived for a Riemannian manifold. This condition is applied to the generalized Euclidean Taub-NUT metrics which admit a Kepler-type symmetry. It is shown that, in general, the Stäckel-Killing tensors involved in the Runge-Lenz vector cannot be expressed as a product of Killing-Yano tensors. The only exception is the original Taub-NUT metric.

  20. Black Hole Spacetimes with Killing-Yano Symmetries

    NASA Astrophysics Data System (ADS)

    Kubizňák, David

    2010-03-01

    We present a brief overview of black hole spacetimes admitting Killing-Yano tensors. In vacuum these include Kerr-NUT-(A)dS metrics and certain black brane solutions. In the presence of matter fields, (conformal) Killing-Yano symmetries are known to exist for the Plebanski-Demianski solution and (trivially) for any spacetime with spherical symmetry. Special attention is devoted to generalized Killing-Yano tensors of black holes in minimal gauged supergravity Several aspects directly related to the existence of Killing-Yano tensors--such as the Kerr-Schild form, algebraic type of spacetimes, and separability of field equations--are also briefly discussed.

  1. Killing acanthamoebae with polyaminopropyl biguanide: quantitation and kinetics.

    PubMed Central

    Burger, R M; Franco, R J; Drlica, K

    1994-01-01

    The two Acanthamoeba species most often implicated in corneal keratitis, A. castellanii and A. polyphaga, were exposed as cysts to polyaminopropyl biguanide (PAPB), a commonly used antimicrobial agent. Killing of amoeba cysts was rapid and extensive, with fewer than 2% of either species surviving 30 s of exposure to > or = 45 ppm of PAPB. Killing kinetics were biphasic, and further exposures of 15 min to 1 h killed greater than 90% of those surviving initial killing. This potency of PAPB, together with its low toxicity to humans when ingested or applied topically, underscores the potential of PAPB as an antiamoebic agent. PMID:8031066

  2. Kinetics of killing Listeria monocytogenes by macrophages: rapid killing accompanying phagocytosis

    SciTech Connect

    Davies, W.A.

    1983-08-01

    The kinetics of bactericidal activity of activated macrophages can be precisely described by a mathematical model in which phagocytosis, killing, digestion, and release of degraded bacterial material are considered to occur continuously. To gain a better understanding of these events, I have determined the period of time between first contact of bacteria with macrophages and the onset of killing. Activated rat peritoneal macrophages were incubated for various times up to 15 min with Listeria monocytogenes previously labeled with /sup 3/H-thymidine and the unassociated bacteria removed by two centrifugations through a density interface. Both cell-associated radioactivity and cell-associated viable bacteria, determined as colony forming units after sonication of the cell pellet, increased with time of incubation. However, the specific viability of these bacteria, expressed as the ratio of number of viable bacteria per unit radioactivity declined with time, as an approximate inverse exponential, after a lag period of 2.9 +/- 0.8 min. Evidence is given that other possible causes for this decline in specific viability, other than death of the bacteria, such as preferential ingestion of dead Listeria, clumping of bacteria, variations in autolytic activity, or release of Listericidins are unlikely. I conclude therefore that activated macrophages kill Listeria approximately 3 min after the cell and the bacterium first make contact.

  3. On the College Student as an Individual: A Bibliography of Arthur W. Chickering. Vance Bibliographies, Public Administration Series: Bibliography P-823.

    ERIC Educational Resources Information Center

    Quay, Richard H.

    A bibliography of Arthur W. Chickering's works on the college student as an individual is presented. Specific topics include the following: diverse student bodies and a changing society, competency-based education, adult development and teaching-learning implications, lifelong learning by handicapped persons, college curriculum development,…

  4. An Item Response Theory-Based, Computerized Adaptive Testing Version of the MacArthur-Bates Communicative Development Inventory: Words & Sentences (CDI:WS)

    ERIC Educational Resources Information Center

    Makransky, Guido; Dale, Philip S.; Havmose, Philip; Bleses, Dorthe

    2016-01-01

    Purpose: This study investigated the feasibility and potential validity of an item response theory (IRT)-based computerized adaptive testing (CAT) version of the MacArthur-Bates Communicative Development Inventory: Words & Sentences (CDI:WS; Fenson et al., 2007) vocabulary checklist, with the objective of reducing length while maintaining…

  5. Identification of Children with Language Impairment: Investigating the Classification Accuracy of the MacArthur-Bates Communicative Development Inventories, Level III

    ERIC Educational Resources Information Center

    Skarakis-Doyle, Elizabeth; Campbell, Wenonah; Dempsey, Lynn

    2009-01-01

    Purpose: This study tested the accuracy with which the MacArthur-Bates Communicative Development Inventories, Level III (CDI-III), a parent report measure of language ability, discriminated children with language impairment from those developing language typically. Method: Parents of 58 children, 49 with typically developing language (age 30 to 42…

  6. Can Severely Language Delayed 3-Year-Olds Be Identified at 18 Months? Evaluation of a Screening Version of the MacArthur-Bates Communicative Development Inventories

    ERIC Educational Resources Information Center

    Westerlund, Monica; Berglund, Eva; Eriksson, Marten

    2006-01-01

    Purpose: To evaluate the effectiveness of a screening instrument (the Swedish Communication Screening at 18 months of age; SCS18), derived from the Swedish MacArthur-Bates Communicative Development Inventory, in identification of 18-month-old children who will be severely language disabled by 3 years of age, the authors (a) analyzed which SCS18's…

  7. Organizing and Making Sense of the Literature: Arthur M. Cohen as Director of the ERIC Clearinghouse for Community Colleges, 1966-2003

    ERIC Educational Resources Information Center

    Palmer, James C.

    2007-01-01

    A major part of Arthur M. Cohen's scholarly legacy is the archive of documents and journal articles catalogued by the ERIC Clearinghouse for Community Colleges, which he led throughout its entire 37-year history (1966-2003). As Clearinghouse director, Cohen oversaw its document acquisition and cataloguing operations, as well as its extensive…

  8. Utility of the MacArthur-Bates Communicative Development Inventory in Identifying Language Abilities of Late-Talking and Typically Developing Toddlers

    ERIC Educational Resources Information Center

    Heilmann, John; Weismer, Susan Ellis; Evans, Julia; Hollar, Christine

    2005-01-01

    The present study investigated the validity of the MacArthur-Bates Communicative Development Inventory (CDI) for a group of toddlers 30 months of age. Study 1 examined the concurrent validity of the CDI for a group of 38 late talkers. Significant correlations were found between the CDI and direct measures of language abilities. Study 2 used…

  9. 7. LOOKING WEST TOWARD SHEEP KILL AREA ON SOUTH END ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. LOOKING WEST TOWARD SHEEP KILL AREA ON SOUTH END OF BUILDING 149; INCLINED CONVEYOR AT LEFT CENTER CARRIED TROLLEYS TO THE AUTOMATIC WASHER/OILER ON THE GALLERY LEVEL - Rath Packing Company, Beef Killing Building, Sycamore Street between Elm & Eighteenth Streets, Waterloo, Black Hawk County, IA

  10. Male Brown-headed Cowbird Attacks and Kills a Nestling

    USGS Publications Warehouse

    Igl, L.D.

    2003-01-01

    I observed a male Brown-headed Cowbird (Molothrus ater) attack and kill a nestling of an unidentified passerine in a grassland field in Day County, South Dakota, in June 2000. The killing or removal of nestlings by female cowbirds has been reported by others, but this behavior has not been documented previously in male cowbirds.

  11. 9 CFR 113.205 - Newcastle Disease Vaccine, Killed Virus.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Virus. 113.205 Section 113.205 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.205 Newcastle Disease Vaccine, Killed Virus. Newcastle Disease...

  12. 9 CFR 113.210 - Feline Calicivirus Vaccine, Killed Virus.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Virus. 113.210 Section 113.210 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.210 Feline Calicivirus Vaccine, Killed Virus. Feline...

  13. 9 CFR 113.210 - Feline Calicivirus Vaccine, Killed Virus.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Virus. 113.210 Section 113.210 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.210 Feline Calicivirus Vaccine, Killed Virus. Feline...

  14. 9 CFR 113.205 - Newcastle Disease Vaccine, Killed Virus.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Virus. 113.205 Section 113.205 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.205 Newcastle Disease Vaccine, Killed Virus. Newcastle Disease...

  15. 9 CFR 113.210 - Feline Calicivirus Vaccine, Killed Virus.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Virus. 113.210 Section 113.210 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.210 Feline Calicivirus Vaccine, Killed Virus. Feline...

  16. 9 CFR 113.211 - Feline Rhinotracheitis Vaccine, Killed Virus.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Virus. 113.211 Section 113.211 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.211 Feline Rhinotracheitis Vaccine, Killed Virus....

  17. 9 CFR 113.211 - Feline Rhinotracheitis Vaccine, Killed Virus.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Virus. 113.211 Section 113.211 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.211 Feline Rhinotracheitis Vaccine, Killed Virus....

  18. 9 CFR 113.211 - Feline Rhinotracheitis Vaccine, Killed Virus.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Virus. 113.211 Section 113.211 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.211 Feline Rhinotracheitis Vaccine, Killed Virus....

  19. 9 CFR 113.210 - Feline Calicivirus Vaccine, Killed Virus.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Virus. 113.210 Section 113.210 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.210 Feline Calicivirus Vaccine, Killed Virus. Feline...

  20. 9 CFR 113.205 - Newcastle Disease Vaccine, Killed Virus.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Virus. 113.205 Section 113.205 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.205 Newcastle Disease Vaccine, Killed Virus. Newcastle Disease...

  1. 9 CFR 113.205 - Newcastle Disease Vaccine, Killed Virus.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Virus. 113.205 Section 113.205 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.205 Newcastle Disease Vaccine, Killed Virus. Newcastle Disease...

  2. 9 CFR 113.211 - Feline Rhinotracheitis Vaccine, Killed Virus.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Virus. 113.211 Section 113.211 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.211 Feline Rhinotracheitis Vaccine, Killed Virus....

  3. 9 CFR 113.210 - Feline Calicivirus Vaccine, Killed Virus.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Virus. 113.210 Section 113.210 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.210 Feline Calicivirus Vaccine, Killed Virus. Feline...

  4. 9 CFR 113.205 - Newcastle Disease Vaccine, Killed Virus.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Virus. 113.205 Section 113.205 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.205 Newcastle Disease Vaccine, Killed Virus. Newcastle Disease...

  5. 9 CFR 113.211 - Feline Rhinotracheitis Vaccine, Killed Virus.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Virus. 113.211 Section 113.211 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.211 Feline Rhinotracheitis Vaccine, Killed Virus....

  6. PDE5 inhibitors enhance celecoxib killing in multiple tumor types.

    PubMed

    Booth, Laurence; Roberts, Jane L; Cruickshanks, Nichola; Tavallai, Seyedmehrad; Webb, Timothy; Samuel, Peter; Conley, Adam; Binion, Brittany; Young, Harold F; Poklepovic, Andrew; Spiegel, Sarah; Dent, Paul

    2015-05-01

    The present studies determined whether clinically relevant phosphodiesterase 5 (PDE5) inhibitors interacted with a clinically relevant NSAID, celecoxib, to kill tumor cells. Celecoxib and PDE5 inhibitors interacted in a greater than additive fashion to kill multiple tumor cell types. Celecoxib and sildenafil killed ex vivo primary human glioma cells as well as their associated activated microglia. Knock down of PDE5 recapitulated the effects of PDE5 inhibitor treatment; the nitric oxide synthase inhibitor L-NAME suppressed drug combination toxicity. The effects of celecoxib were COX2 independent. Over-expression of c-FLIP-s or knock down of CD95/FADD significantly reduced killing by the drug combination. CD95 activation was dependent on nitric oxide and ceramide signaling. CD95 signaling activated the JNK pathway and inhibition of JNK suppressed cell killing. The drug combination inactivated mTOR and increased the levels of autophagy and knock down of Beclin1 or ATG5 strongly suppressed killing by the drug combination. The drug combination caused an ER stress response; knock down of IRE1α/XBP1 enhanced killing whereas knock down of eIF2α/ATF4/CHOP suppressed killing. Sildenafil and celecoxib treatment suppressed the growth of mammary tumors in vivo. Collectively our data demonstrate that clinically achievable concentrations of celecoxib and sildenafil have the potential to be a new therapeutic approach for cancer. PMID:25303541

  7. Control of Influenza and Poliomyelitis with Killed Virus Vaccines

    ERIC Educational Resources Information Center

    Salk, Jonas; Salk, Darrell

    1977-01-01

    Discusses control of poliomyelitis and influenza by live and killed virus vaccines. Considered are the etiological agents, pathogenic mechanisms and epidemiology of each disease. Reviews recent scientific studies of the diseases. Recommends use of killed virus vaccines in controlling both diseases. (CS)

  8. The Seal Killing Controversy: What Are the Facts?

    ERIC Educational Resources Information Center

    Scheffer, Victor B.

    1973-01-01

    Discusses the seal controversy using the harp and Alaska fur seals to illustrate the two distinct issues, i.e., conservation (the effect of killing upon the animal population); and two, morality (the effect of killing upon the human spirit). Factual information combines with personal philosophy. (LK)

  9. PDE5 Inhibitors Enhance Celecoxib Killing in Multiple Tumor Types

    PubMed Central

    BOOTH, LAURENCE; ROBERTS, JANE L.; CRUICKSHANKS, NICHOLA; TAVALLAI, SEYEDMEHRAD; WEBB, TIMOTHY; SAMUEL, PETER; CONLEY, ADAM; BINION, BRITTANY; YOUNG, HAROLD F.; POKLEPOVIC, ANDREW; SPIEGEL, SARAH; DENT, PAUL

    2015-01-01

    The present studies determined whether clinically relevant phosphodiesterase 5 (PDE5) inhibitors interacted with a clinically relevant NSAID, celecoxib, to kill tumor cells. Celecoxib and PDE5 inhibitors interacted in a greater than additive fashion to kill multiple tumor cell types. Celecoxib and sildenafil killed ex vivo primary human glioma cells as well as their associated activated microglia. Knock down of PDE5 recapitulated the effects of PDE5 inhibitor treatment; the nitric oxide synthase inhibitor L-NAME suppressed drug combination toxicity. The effects of celecoxib were COX2 independent. Over-expression of c-FLIP-s or knock down of CD95/FADD significantly reduced killing by the drug combination. CD95 activation was dependent on nitric oxide and ceramide signaling. CD95 signaling activated the JNK pathway and inhibition of JNK suppressed cell killing. The drug combination inactivated mTOR and increased the levels of autophagy and knock down of Beclin1 or ATG5 strongly suppressed killing by the drug combination. The drug combination caused an ER stress response; knock down of IRE1α/XBP1 enhanced killing whereas knock down of eIF2α/ATF4/CHOP suppressed killing. Sildenafil and celecoxib treatment suppressed the growth of mammary tumors in vivo. Collectively our data demonstrate that clinically achievable concentrations of celecoxib and sildenafil have the potential to be a new therapeutic approach for cancer. PMID:25303541

  10. 9. GENERAL INTERIOR VIEW OF BEEF KILLING FLOOR; LOOKING SOUTHEAST; ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. GENERAL INTERIOR VIEW OF BEEF KILLING FLOOR; LOOKING SOUTHEAST; PLATFORMS IN FOREGROUND WERE USED BY SPLITTERS, TRIMMERS AND GOVERNMENT INSPECTORS; SKINNING TABLE RAN ALONG THE WINDOWS NEAR THE CENTER OF THE PHOTO - Rath Packing Company, Beef Killing Building, Sycamore Street between Elm & Eighteenth Streets, Waterloo, Black Hawk County, IA

  11. Null conformal Killing-Yano tensors and Birkhoff theorem

    NASA Astrophysics Data System (ADS)

    Ferrando, Joan Josep; Sáez, Juan Antonio

    2016-04-01

    We study the space-times admitting a null conformal Killing-Yano tensor whose divergence defines a Killing vector. We analyze the similarities and differences with the recently studied non null case (Ferrando and Sáez in Gen Relativ Gravit 47:1911, 2015). The results by Barnes concerning the Birkhoff theorem for the case of null orbits are analyzed and generalized.

  12. 77 FR 18891 - Expediting Review of Pipeline Projects From Cushing, Oklahoma, to Port Arthur, Texas, and Other...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-28

    ...) the functions of the Director of the Office of Management and Budget related to budgetary... agents, or any other person. ] (d) The Director of the Office of Management and Budget is hereby... to public safety, public health, and environmental protection), coordinate and expedite their...

  13. PROJECT MANUAL FOR FULL-SCALE DUAL ALKALI DEMONSTRATION AT LOUISVILLE GAS AND ELECTRIC CO.--PRELIMINARY DESIGN AND COST ESTIMATE

    EPA Science Inventory

    The report is the project manual for the dual-alkali system, designed by Combustion Equipment Associates, Inc./Arthur D. Little, Inc. and being installed to control SO2 emissions from Louisville Gas and Electric Company's Cane Run Unit No. 6 boiler. The project consists of four p...

  14. 'Deadman' and 'Passcode' microbial kill switches for bacterial containment.

    PubMed

    Chan, Clement T Y; Lee, Jeong Wook; Cameron, D Ewen; Bashor, Caleb J; Collins, James J

    2016-02-01

    Biocontainment systems that couple environmental sensing with circuit-based control of cell viability could be used to prevent escape of genetically modified microbes into the environment. Here we present two engineered safeguard systems known as the 'Deadman' and 'Passcode' kill switches. The Deadman kill switch uses unbalanced reciprocal transcriptional repression to couple a specific input signal with cell survival. The Passcode kill switch uses a similar two-layered transcription design and incorporates hybrid LacI-GalR family transcription factors to provide diverse and complex environmental inputs to control circuit function. These synthetic gene circuits efficiently kill Escherichia coli and can be readily reprogrammed to change their environmental inputs, regulatory architecture and killing mechanism. PMID:26641934

  15. Mechanisms of Dendritic Cell Lysosomal Killing of Cryptococcus

    PubMed Central

    Hole, Camaron R.; Bui, Hoang; Wormley, Floyd L.; Wozniak, Karen L.

    2012-01-01

    Cryptococcus neoformans is an opportunistic pulmonary fungal pathogen that disseminates to the CNS causing fatal meningitis in immunocompromised patients. Dendritic cells (DCs) phagocytose C. neoformans following inhalation. Following uptake, cryptococci translocate to the DC lysosomal compartment and are killed by oxidative and non-oxidative mechanisms. DC lysosomal extracts kill cryptococci in vitro; however, the means of antifungal activity remain unknown. Our studies determined non-oxidative antifungal activity by DC lysosomal extract. We examined DC lysosomal killing of cryptococcal strains, anti-fungal activity of purified lysosomal enzymes, and mechanisms of killing against C. neoformans. Results confirmed DC lysosome fungicidal activity against all cryptococcal serotypes. Purified lysosomal enzymes, specifically cathepsin B, inhibited cryptococcal growth. Interestingly, cathepsin B combined with its enzymatic inhibitors led to enhanced cryptococcal killing. Electron microscopy revealed structural changes and ruptured cryptococcal cell walls following treatment. Finally, additional studies demonstrated that osmotic lysis was responsible for cryptococcal death. PMID:23074646

  16. Mechanisms of dendritic cell lysosomal killing of Cryptococcus.

    PubMed

    Hole, Camaron R; Bui, Hoang; Wormley, Floyd L; Wozniak, Karen L

    2012-01-01

    Cryptococcus neoformans is an opportunistic pulmonary fungal pathogen that disseminates to the CNS causing fatal meningitis in immunocompromised patients. Dendritic cells (DCs) phagocytose C. neoformans following inhalation. Following uptake, cryptococci translocate to the DC lysosomal compartment and are killed by oxidative and non-oxidative mechanisms. DC lysosomal extracts kill cryptococci in vitro; however, the means of antifungal activity remain unknown. Our studies determined non-oxidative antifungal activity by DC lysosomal extract. We examined DC lysosomal killing of cryptococcal strains, anti-fungal activity of purified lysosomal enzymes, and mechanisms of killing against C. neoformans. Results confirmed DC lysosome fungicidal activity against all cryptococcal serotypes. Purified lysosomal enzymes, specifically cathepsin B, inhibited cryptococcal growth. Interestingly, cathepsin B combined with its enzymatic inhibitors led to enhanced cryptococcal killing. Electron microscopy revealed structural changes and ruptured cryptococcal cell walls following treatment. Finally, additional studies demonstrated that osmotic lysis was responsible for cryptococcal death. PMID:23074646

  17. Mechanisms of Dendritic Cell Lysosomal Killing of Cryptococcus

    NASA Astrophysics Data System (ADS)

    Hole, Camaron R.; Bui, Hoang; Wormley, Floyd L.; Wozniak, Karen L.

    2012-10-01

    Cryptococcus neoformans is an opportunistic pulmonary fungal pathogen that disseminates to the CNS causing fatal meningitis in immunocompromised patients. Dendritic cells (DCs) phagocytose C. neoformans following inhalation. Following uptake, cryptococci translocate to the DC lysosomal compartment and are killed by oxidative and non-oxidative mechanisms. DC lysosomal extracts kill cryptococci in vitro; however, the means of antifungal activity remain unknown. Our studies determined non-oxidative antifungal activity by DC lysosomal extract. We examined DC lysosomal killing of cryptococcal strains, anti-fungal activity of purified lysosomal enzymes, and mechanisms of killing against C. neoformans. Results confirmed DC lysosome fungicidal activity against all cryptococcal serotypes. Purified lysosomal enzymes, specifically cathepsin B, inhibited cryptococcal growth. Interestingly, cathepsin B combined with its enzymatic inhibitors led to enhanced cryptococcal killing. Electron microscopy revealed structural changes and ruptured cryptococcal cell walls following treatment. Finally, additional studies demonstrated that osmotic lysis was responsible for cryptococcal death.

  18. Effects of the MacArthur Maze Fire and Roadway Collapse on a Spent Nuclear Fuel Transportation Package

    SciTech Connect

    Bajwa, Christopher S.; Easton, Earl P.; Adkins, Harold E.; Cuta, Judith M.; Klymyshyn, Nicholas A.; Suffield, Sarah R.

    2011-03-03

    In 2007, a severe transportation accident occurred near Oakland, California, on a section of Interstate 880 known as the "MacArthur Maze," involving a tractor trailer carrying gasoline which impacted an overpass support column and burst into flames. The subsequent fire caused the collapse of portions of the Interstate 580 overpass onto the remains of the tractor-trailer in less than 20 minutes, due to a reduction of strength in the structural steel exposed to the fire. The US Nuclear Regulatory Commission is in the process of examining the impacts of this accident on the performance of a spent nuclear fuel transportation package, using detailed analysis models, in order to determine the potential regulatory implications related to the safe transport of spent nuclear fuel in the United States. This paper will provide a summary of this ongoing effort and present some preliminary results and conclusions.

  19. The MacArthur Maze Fire and Roadway Collapse: A "Worst Case Scenario" for Spent Nuclear Fuel Transportation?

    SciTech Connect

    Bajwa, Christopher S.; Easton, Earl P.; Adkins, Harold E.; Cuta, Judith M.; Klymyshyn, Nicholas A.; Suffield, Sarah R.

    2012-07-06

    In 2007, a severe transportation accident occurred near Oakland, California, at the interchange known as the "MacArthur Maze." The accident involved a double tanker truck of gasoline overturning and bursting into flames. The subsequent fire reduced the strength of the supporting steel structure of an overhead interstate roadway causing the collapse of portions of that overpass onto the lower roadway in less than 20 minutes. The US Nuclear Regulatory Commission has analyzed what might have happened had a spent nuclear fuel transportation package been involved in this accident, to determine if there are any potential regulatory implications of this accident to the safe transport of spent nuclear fuel in the United States. This paper provides a summary of this effort, presents preliminary results and conclusions, and discusses future work related to the NRC's analysis of the consequences of this type of severe accident.

  20. Epidemiology and public health in 1906 England: Arthur Newsholme's methodological innovation to study breastfeeding and fatal diarrhea.

    PubMed

    Morabia, Alfredo; Rubenstein, Beth; Victora, Cesar G

    2013-07-01

    In 1906 Arthur Newsholme linked artificial feeding and fatal diarrhea in infants aged one year and younger on the basis of two independent sources of information: mortality registration and a three-year (1903-1905) census of infants from Brighton, United Kingdom. Artificial feeding was more common in the infants who had died (89.3%) than in those in the survey (22.3%). However, boldly assuming the two data sources were nested, Newsholme computed the risks of fatal diarrhea: these were 48 times greater for infants fed fresh cow's milk and 94 times greater for those fed condensed milk than for infants who were exclusively breastfed. This mode of computing risks and risk ratios before the invention of the cohort study design was more innovative than was the usual investigation techniques of his contemporary epidemiologists. Newsholme's conclusions were consistent with the current knowledge that breastfeeding protects against fatal diarrhea. PMID:23678939

  1. Tackling Shell Shock in Great War Oxford: Thomas Saxty Good, William McDougall, and James Arthur Hadfield.

    PubMed

    Stewart, John

    2016-01-01

    Shell shock was an important object of diagnostic and therapeutic concern in Oxford during the Great War. The efforts of three Oxford physicians--Thomas Saxty Good, William McDougall, and James Arthur Hadfield--are of particular significance to our story. All worked on the problem at various sites throughout the city. They often collaborated. All were committed to employing innovative techniques such as psychotherapy and hypnosis. Each rose, to differing extents, to prominence in the field of psychological medicine during the succeeding decades. Yet all have been neglected in the current historiography. I argue that a close examination of their practices reveals a curious combination of therapeutic pragmatism and psychoanalytically informed techniques that later helped inform clinical psychology's challenge to psychiatry's dominance over the concept and care of mental disorder. PMID:27344909

  2. Epidemiology and Public Health in 1906 England: Arthur Newsholme’s Methodological Innovation to Study Breastfeeding and Fatal Diarrhea

    PubMed Central

    Rubenstein, Beth; Victora, Cesar G.

    2013-01-01

    In 1906 Arthur Newsholme linked artificial feeding and fatal diarrhea in infants aged one year and younger on the basis of two independent sources of information: mortality registration and a three-year (1903–1905) census of infants from Brighton, United Kingdom. Artificial feeding was more common in the infants who had died (89.3%) than in those in the survey (22.3%). However, boldly assuming the two data sources were nested, Newsholme computed the risks of fatal diarrhea: these were 48 times greater for infants fed fresh cow’s milk and 94 times greater for those fed condensed milk than for infants who were exclusively breastfed. This mode of computing risks and risk ratios before the invention of the cohort study design was more innovative than was the usual investigation techniques of his contemporary epidemiologists. Newsholme’s conclusions were consistent with the current knowledge that breastfeeding protects against fatal diarrhea. PMID:23678939

  3. Boromycin Kills Mycobacterial Persisters without Detectable Resistance

    PubMed Central

    Moreira, Wilfried; Aziz, Dinah B.; Dick, Thomas

    2016-01-01

    Boromycin is a boron-containing polyether macrolide antibiotic isolated from Streptomyces antibioticus. It was shown to be active against Gram positive bacteria and to act as an ionophore for potassium ions. The antibiotic is ineffective against Gram negative bacteria where the outer membrane appears to block access of the molecule to the cytoplasmic membrane. Here we asked whether boromycin is active against Mycobacterium tuberculosis which, similar to Gram negative bacteria, possesses an outer membrane. The results show that boromycin is a potent inhibitor of mycobacterial growth (MIC50 = 80 nM) with strong bactericidal activity against growing and non-growing drug tolerant persister bacilli. Exposure to boromycin resulted in a rapid loss of membrane potential, reduction of the intracellular ATP level and leakage of cytoplasmic protein. Consistent with boromycin acting as a potassium ionophore, addition of KCl to the medium blocked its antimycobacterial activity. In contrast to the potent antimycobacterial activities of the polyether macrolide, its cytotoxicity and haemolytic activity were low (CC50 = 30 μM, HC50 = 40 μM) with a selectivity index of more than 300. Spontaneous resistant mutants could not be isolated suggesting a mutation frequency of less than 10-9/CFU. Taken together, the results suggests that targeting mycobacterial transmembrane ion gradients may be an attractive chemotherapeutic intervention level to kill otherwise drug tolerant persister bacilli, and to slow down the development of genetic antibiotic resistance. PMID:26941723

  4. Clomipramine kills Trypanosoma brucei by apoptosis.

    PubMed

    de Silva Rodrigues, Jean Henrique; Stein, Jasmin; Strauss, Mariana; Rivarola, Héctor Walter; Ueda-Nakamura, Tânia; Nakamura, Celso Vataru; Duszenko, Michael

    2016-06-01

    Drug repositioning, i.e. use of existing medicals to treat a different illness, is especially rewarding for neglected tropical diseases (NTD), since in this field the pharmaceutical industry is rather reluctant to spend vast investments for drug development. NTDs afflict primarily poor populations in under-developed countries, which minimizes financial profit. Here we investigated the trypanocidal effect of clomipramine, a commercial antipsychotic drug, on Trypanosoma brucei. The data showed that this drug killed the parasite with an IC50 of about 5μM. Analysis of the involved cell death mechanism revealed furthermore an initial autophagic stress response and finally the induction of apoptosis. The latter was substantiated by a set of respective markers such as phosphatidylserine exposition, DNA degradation, loss of the inner mitochondrial membrane potential and characteristic morphological changes. Clomipramine was described as a trypanothione inhibitor, but as judged from our results it also showed DNA binding capacities and induced substantial morphological changes. We thus consider it likely that the drug induces a multifold adverse interaction with the parasite's physiology and induces stress in a way that trypanosomes cannot cope with. PMID:27086198

  5. Boromycin Kills Mycobacterial Persisters without Detectable Resistance.

    PubMed

    Moreira, Wilfried; Aziz, Dinah B; Dick, Thomas

    2016-01-01

    Boromycin is a boron-containing polyether macrolide antibiotic isolated from Streptomyces antibioticus. It was shown to be active against Gram positive bacteria and to act as an ionophore for potassium ions. The antibiotic is ineffective against Gram negative bacteria where the outer membrane appears to block access of the molecule to the cytoplasmic membrane. Here we asked whether boromycin is active against Mycobacterium tuberculosis which, similar to Gram negative bacteria, possesses an outer membrane. The results show that boromycin is a potent inhibitor of mycobacterial growth (MIC50 = 80 nM) with strong bactericidal activity against growing and non-growing drug tolerant persister bacilli. Exposure to boromycin resulted in a rapid loss of membrane potential, reduction of the intracellular ATP level and leakage of cytoplasmic protein. Consistent with boromycin acting as a potassium ionophore, addition of KCl to the medium blocked its antimycobacterial activity. In contrast to the potent antimycobacterial activities of the polyether macrolide, its cytotoxicity and haemolytic activity were low (CC50 = 30 μM, HC50 = 40 μM) with a selectivity index of more than 300. Spontaneous resistant mutants could not be isolated suggesting a mutation frequency of less than 10(-9)/CFU. Taken together, the results suggests that targeting mycobacterial transmembrane ion gradients may be an attractive chemotherapeutic intervention level to kill otherwise drug tolerant persister bacilli, and to slow down the development of genetic antibiotic resistance. PMID:26941723

  6. Combinatorial stresses kill pathogenic Candida species.

    PubMed

    Kaloriti, Despoina; Tillmann, Anna; Cook, Emily; Jacobsen, Mette; You, Tao; Lenardon, Megan; Ames, Lauren; Barahona, Mauricio; Chandrasekaran, Komelapriya; Coghill, George; Goodman, Daniel; Gow, Neil A R; Grebogi, Celso; Ho, Hsueh-Lui; Ingram, Piers; McDonagh, Andrew; de Moura, Alessandro P S; Pang, Wei; Puttnam, Melanie; Radmaneshfar, Elahe; Romano, Maria Carmen; Silk, Daniel; Stark, Jaroslav; Stumpf, Michael; Thiel, Marco; Thorne, Thomas; Usher, Jane; Yin, Zhikang; Haynes, Ken; Brown, Alistair J P

    2012-10-01

    Pathogenic microbes exist in dynamic niches and have evolved robust adaptive responses to promote survival in their hosts. The major fungal pathogens of humans, Candida albicans and Candida glabrata, are exposed to a range of environmental stresses in their hosts including osmotic, oxidative and nitrosative stresses. Significant efforts have been devoted to the characterization of the adaptive responses to each of these stresses. In the wild, cells are frequently exposed simultaneously to combinations of these stresses and yet the effects of such combinatorial stresses have not been explored. We have developed a common experimental platform to facilitate the comparison of combinatorial stress responses in C. glabrata and C. albicans. This platform is based on the growth of cells in buffered rich medium at 30°C, and was used to define relatively low, medium and high doses of osmotic (NaCl), oxidative (H(2)O(2)) and nitrosative stresses (e.g., dipropylenetriamine (DPTA)-NONOate). The effects of combinatorial stresses were compared with the corresponding individual stresses under these growth conditions. We show for the first time that certain combinations of combinatorial stress are especially potent in terms of their ability to kill C. albicans and C. glabrata and/or inhibit their growth. This was the case for combinations of osmotic plus oxidative stress and for oxidative plus nitrosative stress. We predict that combinatorial stresses may be highly significant in host defences against these pathogenic yeasts. PMID:22463109

  7. [Time point and methods for emergency killing in cattle].

    PubMed

    Khol, J L; Schafbauer, T; Wittek, T

    2016-01-01

    Emergency killing is defined as the killing of injured or ill animals to avoid excessive pain or harm. Decision-making for emergency killing or a prolonged therapy can be difficult and has to be based on the case history and results of the clinical examination contributing to the prognosis, particularly in downer cows. Evaluation of enzyme activities and total bilirubin can be used as additional factors pointing to a guarded prognosis; however, none of these parameters provides a clear cut-off value indicating a poor prognosis and mandatory emergency killing. Euthanasia by intravenous drug application is seen as the least stressful method of killing and should therefore always be the first method of choice for emergency killing in cattle. Drugs containing pentobarbital as well as a combination of three different drugs (T61-Injektionslösung, MSD Animal Health) are available for euthanasia in cattle. All drugs must be administered by a veterinarian. Before application of pentobarbital, an animal should be deeply sedated. The administration of T61 requires anaesthesia of the animal and it is not licensed for use in pregnant animals. Alternative methods for emeragency killing, including captive bolt stunning and the use of firearms, although not regularly performed by veterinarians, should be assessed concerning their correct application and performance. When captive bolt stunning or emergency killing using firearms is performed, the correct position of the device is crucial as well as a quick exsanguination or the application of a pithing rod for the actual killing of the animal after captive bolt stunning. In addition to medical considerations, economic and personal factors contribute to the decision about emergency killing in cattle. Therefore, veterinarians should aim to evaluate each case thoroughly based on personal knowledge and experience, case history, clinical findings and laboratory parameters to avoid prolonged suffering of the animal. PMID:26830543

  8. On pseudo-Riemannian manifolds with many Killing spinors

    SciTech Connect

    Alekseevsky, D. V.; Cortes, V.

    2009-02-02

    Let M be a pseudo-Riemannian spin manifold of dimension n and signature s and denote by N the rank of the real spinor bundle. We prove that M is locally homogeneous if it admits more than (3/4)N independent Killing spinors with the same Killing number, unless n {identical_to} 1(mod 4) and s {identical_to} 3(mod 4). We also prove that M is locally homogeneous if it admits k{sub +} independent Killing spinors with Killing number {lambda} and k{sub -} independent Killing spinors with Killing number -{lambda} such that k{sub +}+k{sub -}>(3/2)N, unless n {identical_to} s {identical_to} 3(mod 4). Similarly, a pseudo-Riemannian manifold with more than (3/4)N independent conformal Killing spinors is conformally locally homogeneous. For (positive or negative) definite metrics, the bounds (3/4)N and (3/2)N in the above results can be relaxed to (1/2)N and N, respectively. Furthermore, we prove that a pseudo-Riemannnian spin manifold with more than (3/4)N parallel spinors is flat and that (1/4)N parallel spinors suffice if the metric is definite. Similarly, a Riemannnian spin manifold with more than (3/8)N Killing spinors with the Killing number {lambda}(set-membership sign)R has constant curvature 4{lambda}{sup 2}. For Lorentzian or negative definite metrics the same is true with the bound (1/2)N. Finally, we give a classification of (not necessarily complete) Riemannian manifolds admitting Killing spinors, which provides an inductive construction of such manifolds.

  9. Managing Threat, Cost, and Incentive to Kill: The Short- and Long-Term Effects of Intervention in Mass Killings

    ERIC Educational Resources Information Center

    Kathman, Jacob D.; Wood, Reed M.

    2011-01-01

    How do third-party interventions affect the severity of mass killings? The authors theorize that episodes of mass killing are the consequence of two factors: (1) the threat perceptions of the perpetrators and (2) the cost of implementing genocidal policies relative to other alternatives. To reduce genocidal hostilities, interveners must address…

  10. To kill or not to kill, that is the question: cytocidal antimalarial drug resistance

    PubMed Central

    Roepe, Paul D.

    2014-01-01

    Elucidating mechanisms of antimalarial drug resistance accelerates development of improved diagnostics and the design of new, effective malaria therapy. Recently, several studies have emphasized that chloroquine (CQ) resistance (CQR) can be quantified in two very distinct ways, depending on whether sensitivity to the growth inhibitory effects or parasite – kill effects of the drug are being measured. It is now clear that these cytostatic and cytocidal CQR phenotypes are not equivalent, and recent genetic, cell biological, and biophysical evidence suggests how the molecular mechanisms may overlap. These conclusions have important implications for elucidating other drug resistance phenomena and emphasize new concepts that are essential for the development of new drug therapy. PMID:24530127

  11. Did Vertigo Kill America's Forgotten Astronaut?

    NASA Technical Reports Server (NTRS)

    Bendrick, Gregg A.; Merlin, Peter W.

    2007-01-01

    On November 15, 1967, U.S. Air Force test pilot Major Michael J. Adams was killed while flying the X-15 rocket-propelled research vehicle in a parabolic spaceflight profile. This flight was part of a joint effort with NASA. An electrical short in one of the experiments aboard the vehicle caused electrical transients, resulting in excessive workload by the pilot. At altitude Major Adams inappropriately initiated a flat spin that led to a series of unusual aircraft attitudes upon atmospheric re-entry, ultimately causing structural failure of the airframe. Major Adams was known to experience vertigo (i.e. spatial disorientation) while flying the X-15, but all X-15 pilots most likely experienced vertigo (i.e. somatogravic, or "Pitch-Up", illusion) as a normal physiologic response to the accelerative forces involved. Major Adams probably experienced vertigo to a greater degree than did others, since prior aeromedical testing for astronaut selection at Brooks AFB revealed that he had an unusually high degree of labyrinthine sensitivity. Subsequent analysis reveals that after engine burnout, and through the zenith of the flight profile, he likely experienced the oculoagravic ("Elevator") illusion. Nonetheless, painstaking investigation after the mishap revealed that spatial disorientation (Type II, Recognized) was NOT the cause, but rather, a contributing factor. The cause was in fact the misinterpretation of a dual-use flight instrument (i.e. Loss of Mode Awareness), resulting in confusion between yaw and roll indications, with subsequent flight control input that was inappropriate. Because of the altitude achieved on this flight, Major Adams was awarded Astronaut wings posthumously. Understanding the potential for spatial disorientation, particularly the oculoagravic illusion, associated with parabolic spaceflight profiles, and understanding the importance of maintaining mode awareness in the context of automated cockpit design, are two lessons that have direct

  12. Can Nanomedicines Kill Cancer Stem Cells?

    PubMed Central

    Zhao, Yi; Alakhova, Daria Y.; Kabanov, Alexander V.

    2014-01-01

    Most tumors are heterogeneous and many cancers contain small population of highly tumorigenic and intrinsically drug resistant cancer stem cells (CSCs). Like normal stem cell, CSCs have ability to self-renew and differentiate to other tumor cell types. They are believed to be a source for drug resistance, tumor recurrence and metastasis. CSCs often overexpress drug efflux transporters, spend most of their time in non-dividing G0 cell cycle state, and therefore, can escape the conventional chemotherapies. Thus, targeting CSCs is essential for developing novel therapies to prevent cancer relapse and emerging of drug resistance. Nanocarrier-based therapeutic agents (nanomedicines) have been used to achieve longer circulation times, better stability and bioavailability over current therapeutics. Recently, some groups have successfully applied nanomedicines to target CSCs to eliminate the tumor and prevent its recurrence. These approaches include 1) delivery of therapeutic agents (small molecules, siRNA, antibodies) that affect embryonic signaling pathways implicated in self-renewal and differentiation in CSCs, 2) inhibiting drug efflux transporters in an attempt to sensitize CSCs to therapy, 3) targeting metabolism in CSCs through nanoformulated chemicals and field-responsive magnetic nanoparticles and carbon nanotubes, and 4) disruption of multiple pathways in drug resistant cells using combination of chemotherapeutic drugs with amphiphilic Pluronic block copolymers. Despite clear progress of these studies the challenges of targeting CSCs by nanomedicines still exist and leave plenty of room for improvement and development. This review summarizes biological processes that are related to CSCs, overviews the current state of anti-CSCs therapies, and discusses state-of-the-art nanomedicine approaches developed to kill CSCs. PMID:24120657

  13. Kill a brand, keep a customer.

    PubMed

    Kumar, Nirmalya

    2003-12-01

    Most brands don't make much money. Year after year, businesses generate 80% to 90% of their profits from less than 20% of their brands. Yet most companies tend to ignore loss-making brands, unaware of the hidden costs they incur. That's because executives believe it's easy to erase a brand; they have only to stop investing in it, they assume, and it will die a natural death. But they're wrong. When companies drop brands clumsily, they antagonize loyal customers: Research shows that seven times out of eight, when firms merge two brands, the market share of the new brand never reaches the combined share of the two original ones. It doesn't have to be that way. Smart companies use a four-step process to kill brands methodically. First, CEOs make the case for rationalization by getting groups of senior executives to conduct joint audits of the brand portfolio. These audits make the need to prune brands apparent throughout the organization. In the next stage, executives need to decide how many brands will be retained, which they do either by setting broad parameters that all brands must meet or by identifying the brands they need in order to cater to all the customer segments in their markets. Third, executives must dispose of the brands they've decided to drop, deciding in each case whether it is appropriate to merge, sell, milk, or just eliminate the brand outright. Finally, it's critical that executives invest the resources they've freed to grow the brands they've retained. Done right, dropping brands will result in a company poised for new growth from the source where it's likely to be found--its profitable brands. PMID:14712547

  14. Laser Microbial Killing and Biofilm Disruption

    NASA Astrophysics Data System (ADS)

    Krespi, Yosef P.; Kizhner, Victor

    2009-06-01

    Objectives: To analyze the ability of NIR lasers to reduce bacterial load and demonstrate the capability of fiber-based Q-switched Nd:YAG laser disrupting biofilm. Study Design: NIR diode laser was tested in vitro and in vivo using pathogenic microorganisms (S. aureus, S. pneumoniae, P. aeruginosa). In addition biofilms were grown from clinical Pseudomonas isolates and placed in culture plates, screws, tympanostomy tubes and PET sutures. Methods: In the animal experiments acute rhinosinusitis model was created by packing the rabbit nose with bacteria soaked solution. The nasal pack was removed in two days and nose was exposed to laser irradiation. A 940 nm diode laser with fiber diffuser was used. Nasal cultures were obtained before and after the laser treatments. Animals were sacrificed fifteen days following laser treatment and bacteriologic/histologic results analyzed. Q-switched Nd:YAG laser generated shockwave pulses were delivered on biofilm using special probes over culture plates, screws, tubes, and PET sutures for the biofilm experiments. Results: Average of two log bacteria reduction was achieved with NIR laser compared to controls. Histologic studies demonstrated preservation of tissue integrity without significant damage to mucosa. Biofilms were imaged before, during and after treatment using a confocal microscope. During laser-generated shockwave application, biofilm was initially seen to oscillate and eventually break off. Large and small pieces of biofilm were totally and instantly removed from the surface to which they were attached in seconds. Conclusions: Significant bacterial reduction was achieved with NIR laser therapy in this experimental in vitro and animal study. In addition we disrupted Pseudomonas aeruginosa biofilms using Q-switched Nd:YAG laser and special probes generating plasma and shockwave. This new and innovative method of bacteria killing and biofilm disruption without injuring host tissue may have clinical application in the

  15. Gauge theories on A(dS) space and Killing vectors

    SciTech Connect

    Banerjee, Rabin Majhi, Bibhas Ranjan

    2008-03-15

    We provide a general technique for collectively analysing a manifestly covariant formulation of non-abelian gauge theories on both anti-de Sitter as well as de Sitter spaces. This is done by stereographically projecting the corresponding theories, defined on a flat Minkowski space, onto the surface of the A(dS) hyperboloid. The gauge and matter fields in the two descriptions are mapped by conformal Killing vectors and conformal Killing spinors, respectively. A bilinear map connecting the spinors with the vector is established. Different forms of gauge fixing conditions and their equivalence are discussed. The U(1) axial anomaly as well as the non-abelian covariant and consistent chiral anomalies on A(dS) space are obtained. Electric-magnetic duality is demonstrated. The zero curvature limit is shown to yield consistent findings.

  16. HIV transcription is induced with some forms of cell killing

    SciTech Connect

    Woloschak, G.E.; Schreck, S.; Panozzo, J.; Chang-Liu, C.-M.; Libertin, C.R.

    1996-11-01

    Using HeLa cells stably transfected with an HIV-LTR-CAT construct`, we demonstrated a peak in CAT induction that occurs in viable (but not necessarily cell-division-competent) cells 24 h following exposure to some cell-killing agents. {Gamma} rays were the only cell-killing agent which did not induce HIV transcription; this can be attributed to the fact that {gamma}-ray-induced apoptotic death requires function p53, which is missing in HeLa cells. For all other agents, HIV-LTR induction was dose-dependent and correlated with the amount of cell killing that occurred in the culture.

  17. Book Review: Evans, Arthur V. 2014. Beetles of Eastern North America. Princeton University Press, Princeton, New Jersey, U.S.A. 560 pp. ISBN 978-0-691-13304-1 (paperback). Price: US $35.00

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A book review is presented for “Beetles of Eastern North America” by Arthur V. Evans. This 560 page book was published in 2014 and treats over 1,400 species of beetles distributed in eastern North America....

  18. Antibacterial activity of silver-killed bacteria: the "zombies" effect.

    PubMed

    Wakshlak, Racheli Ben-Knaz; Pedahzur, Rami; Avnir, David

    2015-01-01

    We report a previously unrecognized mechanism for the prolonged action of biocidal agents, which we denote as the zombies effect: biocidally-killed bacteria are capable of killing living bacteria. The concept is demonstrated by first killing Pseudomonas aeruginosa PAO1 with silver nitrate and then challenging, with the dead bacteria, a viable culture of the same bacterium: Efficient antibacterial activity of the killed bacteria is observed. A mechanism is suggested in terms of the action of the dead bacteria as a reservoir of silver, which, due to Le-Chatelier's principle, is re-targeted to the living bacteria. Langmuirian behavior, as well as deviations from it, support the proposed mechanism. PMID:25906433

  19. Prevent Tipping Furniture from Injuring or Killing Young Children

    MedlinePlus

    ... Emergencies Prevent Tipping Furniture from Injuring or Killing Young Children The nation’s emergency physicians handle tragic situations ... Emergency Physicians. “Every parent or guardian of a young child should look around their homes and imagine ...

  20. PFIESTERIA SHUMWAYAE KILLS FISH BY MICROPREDATION NOT ECOTOXIN SECRETION

    EPA Science Inventory

    Massive fish kills in mid-Atlantic USA estuaries involving several million Atlantic menhaden, Brevoortia tyrannus,have been attributed to dinoflagellates of the toxic Pfiesteria complex (TPC). Potent ichthyotoxins secreted during Pfiesteria blooms are thought to be responsible fo...

  1. Killing superalgebra deformations of ten-dimensional supergravity backgrounds

    NASA Astrophysics Data System (ADS)

    Figueroa-O'Farrill, José; Vercnocke, Bert

    2007-12-01

    We explore Lie superalgebra deformations of the Killing superalgebras of some ten-dimensional supergravity backgrounds. We prove the rigidity of the Poincaré superalgebras in types I, IIA and IIB, as well as of the Killing superalgebra of the Freund Rubin vacuum of type IIB supergravity. We also prove rigidity of the Killing superalgebras of the NS5-, D0-, D3-, D4- and D5-branes, whereas we exhibit the possible deformations of the D1-, D2-, D6- and D7-brane Killing superalgebras, as well as of that of the type II fundamental string solutions. We relate the superalgebra deformations of the D2- and D6-branes to those of the (delocalized) M2-brane and the Kaluza Klein monopole, respectively. The good behaviour under Kaluza Klein reduction suggests that the deformed superalgebras ought to have a geometric interpretation.

  2. Hidden symmetries and killing tensors on curved spaces

    SciTech Connect

    Ianus, S.; Visinescu, M.; Vilcu, G. E.

    2010-11-15

    Higher-order symmetries corresponding to Killing tensors are investigated. The intimate relation between Killing-Yano tensors and nonstandard supersymmetries is pointed out. In the Dirac theory on curved spaces, Killing-Yano tensors generate Dirac-type operators involved in interesting algebraic structures as dynamical algebras or even infinite dimensional algebras or superalgebras. The general results are applied to space-times which appear in modern studies. One presents the infinite dimensional superalgebra of Dirac type operators on the 4-dimensional Euclidean Taub-NUT space that can be seen as a twisted loop algebra. The existence of the conformal Killing-Yano tensors is investigated for some spaces with mixed 3-Sasakian structures.

  3. Could Killing Bacterial Subpopulations Hit Tuberculosis out of the Park?

    PubMed

    Baranowski, Catherine; Rubin, Eric J

    2016-07-14

    One hurdle to treating tuberculosis could be that it is so difficult to kill nonreplicating subpopulations of the causative pathogens. This work describes two new cephalosporin derivatives that specifically target this population of Mycobacterium tuberculosis. PMID:27322073

  4. Grim Job Talks Are a Buzz Kill

    ERIC Educational Resources Information Center

    Shapiro, Dan

    2012-01-01

    This article takes a look at five mistakes that candidates should avoid making during their research presentations. These mistakes are the following: (1) they didn't do any research on the norms of the campus culture; (2) they presented a single, well-thought-out project that had no future; (3) they didn't use the opportunity to demonstrate their…

  5. Conformal Killing Vectors in LRS Bianchi Type V Spacetimes

    NASA Astrophysics Data System (ADS)

    Suhail, Khan; Tahir, Hussain; Ashfaque, H. Bokhari; Gulzar, Ali Khan

    2016-03-01

    In this note, we investigate conformal Killing vectors (CKVs) of locally rotationally symmetric (LRS) Bianchi type V spacetimes. Subject to some integrability conditions, CKVs up to implicit functions of (t,x) are obtained. Solving these integrability conditions in some particular cases, the CKVs are completely determined, obtaining a classification of LRS Bianchi type V spacetimes. The inheriting conformal Killing vectors of LRS Bianchi type V spacetimes are also discussed.

  6. 7 CFR 29.1018 - Fire-killed.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 2 2012-01-01 2012-01-01 false Fire-killed. 29.1018 Section 29.1018 Agriculture... INSPECTION Standards Official Standard Grades for Flue-Cured Tobacco (u.s. Types 11, 12, 13, 14 and Foreign Type 92) § 29.1018 Fire-killed. Any leaf of which 5 percent or more of its surface has a set...

  7. 7 CFR 29.1018 - Fire-killed.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Fire-killed. 29.1018 Section 29.1018 Agriculture... INSPECTION Standards Official Standard Grades for Flue-Cured Tobacco (u.s. Types 11, 12, 13, 14 and Foreign Type 92) § 29.1018 Fire-killed. Any leaf of which 5 percent or more of its surface has a set...

  8. 7 CFR 29.1018 - Fire-killed.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 2 2014-01-01 2014-01-01 false Fire-killed. 29.1018 Section 29.1018 Agriculture... INSPECTION Standards Official Standard Grades for Flue-Cured Tobacco (u.s. Types 11, 12, 13, 14 and Foreign Type 92) § 29.1018 Fire-killed. Any leaf of which 5 percent or more of its surface has a set...

  9. 7 CFR 29.1018 - Fire-killed.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Fire-killed. 29.1018 Section 29.1018 Agriculture... INSPECTION Standards Official Standard Grades for Flue-Cured Tobacco (u.s. Types 11, 12, 13, 14 and Foreign Type 92) § 29.1018 Fire-killed. Any leaf of which 5 percent or more of its surface has a set...

  10. 7 CFR 29.1018 - Fire-killed.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 2 2013-01-01 2013-01-01 false Fire-killed. 29.1018 Section 29.1018 Agriculture... INSPECTION Standards Official Standard Grades for Flue-Cured Tobacco (u.s. Types 11, 12, 13, 14 and Foreign Type 92) § 29.1018 Fire-killed. Any leaf of which 5 percent or more of its surface has a set...

  11. Dynamic kill of an uncontrolled CO/sub 2/ well

    SciTech Connect

    Lynch, R.D.; McBride, E.J.; Perkins, T.K.; Wiley, M.E.

    1985-07-01

    In March 1982 a CO/sub 2/ well in the Sheep Mountain Unit, CO, blew out. This well was brought under control in early April 1982 by the dynamic injection of drag-reduced brine followed by mud. This paper discusses the events and field activities that followed the blowout and led to the successful kill operation. Also included is a discussion of two initial, unsuccessful kill attempts, associated mechanical problems, and the understanding gained therefrom. Analyses of wellbore and reservoir hydraulics led to an understanding of the freely flowing well. Injection of kill fluid down the drillpipe was possible, but the small pipe diameter, particularly that of the heavy wall drillpipe, significantly limited the rate of kill-fluid injection. The kill operation was further complicated by the high flow capacity of CO/sub 2/ from the reservoir. The high CO/sub 2/ flow rate efficiently gas-lifted the kill fluid up the annulus and thus tended to maintain a low bottomhole pressure (BHP). Further analysis of the hydraulics of the system suggested two alternatives for dynamically killing the well: (1) use of highly drag-reduced fluids of moderate density such as water or brine, and (2) use of non-drag-reduced mud with a density greater than about 18 lbm/gal (2100 kg/m/sup 3/). The well was killed successfully with 10.5-lbm/gal (1260-kg/m/sup 3/) brine, which exhibited 72% drag reduction in surface lines and drillpipe at an injection rate of 60 bbl/min (570 m/sup 3//h).

  12. 1. GENERAL VIEW OF HOG KILLING ROOM ON LEVEL 4; ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. GENERAL VIEW OF HOG KILLING ROOM ON LEVEL 4; LOOKING NORTHWEST; A PORTION OF THE SCALDING TANK IS VISIBLE AT EXTREME RIGHT, CENTER; CONCRETE PYLONS AT LOWER RIGHT SUPPORTED BY SCRAPING MACHINE; FINAL SCRAPING WAS DONE BY WORKERS STANDING ON ELEVATED PLATFORMS AT LEFT; BATHTUB-SHAPED CART NEAR CENTER OF PHOTO WAS USED TO TRANSPORT OFFAL TO RENDERING AREAS - Rath Packing Company, Hog Killing Building, Sycamore Street between Elm & Eighteenth Streets, Waterloo, Black Hawk County, IA

  13. Approximate Killing vectors on S{sup 2}

    SciTech Connect

    Cook, Gregory B.; Whiting, Bernard F.

    2007-08-15

    We present a new method for computing the best approximation to a Killing vector on closed 2-surfaces that are topologically S{sup 2}. When solutions of Killing's equation do not exist, this method is shown to yield results superior to those produced by existing methods. In addition, this method appears to provide a new tool for studying the horizon geometry of distorted black holes.

  14. Dynamic kill of an uncontrolled CO/sub 2/ well

    SciTech Connect

    Lynch, R.D.; Mcbride, E.J.; Perkins, T.K.; Wiley, M.E.

    1983-02-01

    In March 1982 a carbon-dioxide well in the Sheep Mountain Unit, Colorado, blew out. This well was brought under control in early April 1982 by the dynamic injection of drag-reduced brine followed by mud. Analyses of wellbore and reservoir hydraulics led to an understanding of the freely flowing well. Injection of kill fluid down the drill pipe was possible, but the small pipe diameter, particularly that of the heavy wall drill pipe, significantly limited the rate of kill fluid injection. The kill operation was further complicated by the high flow capacity of CO/sub 2/ from the reservoir. The high CO/sub 2/ flow rate efficiently gas-lifted the kill fluid up the annulus and thus tended to maintain a low bottomhole pressure. Further analysis of the hydraulics of the system suggested two alternatives for dynamically killing the well: the use of highly drag-reduced fluids of moderate density such as water or brine, and the use of non-drag-reduced mud with a density greater than about 18 ppg. The well was successfully killed with 10.5 ppg brine which exhibited 72 percent drag reduction in surface lines and drill pipe at an injection rate of 60 bbl/min.

  15. The Lake Arthur complex, Jefferson Davis and Vermilion Parishes, Louisiana: How it fits into the regional depositional framework of the Camerina A to Miogypsinoides A interval

    SciTech Connect

    Smith, N.E. )

    1990-09-01

    The Lake Arthur Complex is one of the many normal mega-sized structural features that fit into the normal South Louisiana regional framework when completely studied and understood. To explain this mega-feature requires an understanding of the regional structure and of the stratigraphic depositional patterns of each of the major paleontological sequences from the older Bolivina mexicana through the younger Discorbis intervals, covering sediments of middle Oligocene age to the younger early Miocene age. The Lake Arthur Complex encompasses six producing field areas as recognized by the Louisiana Department of Conservation. These fields produce from multiple sands ranging in age from middle Oligocene through early Miocene. The productive areas are related to a combination of their structural relationship to the overall complex, the stratigraphic depositional patterns of the producing sands as related to regional depositional faulting, and the stratigraphic depositional patterns of the producing sands related to the growth history of this Complex. Each of these variables, or a combination of these variables, has a significant controlling effect on the individual producing areas within the Complex. One of the more significant producing intervals of the Lake Arthur Complex is the sand packages in the Camerina A to Miogypsinoides A middle Oligocene sediments. Ultimately the Lake Arthur Complex may produce in excess of 5 tcf of gas with the Camerina A to Miogypsinoides A responsible for approximately 75% of the estimated production. Each of the significant Camerina A to Miogypsinoides A producing areas in the overall complex is discussed structurally and stratigraphically, including the relationship to the overall regional depositional framework and history of the Camerina A-Miogypsinoides A stratigraphic interval.

  16. Arthur J. Dellinger, Sr. , nomination. Hearing before the Committee on Energy and Natural Resources, United States Senate, Ninety-Seventh Congress, Second Session, June 28, 1982

    SciTech Connect

    Not Available

    1982-01-01

    A one-day confirmation hearing on the nomination of Arthur J. Dellinger, Sr. as DOE Deputy Inspector General (IG) focused on his ability and willingness to perform the duties and on his technical qualifications. The Deputy IG assists the IG in fraud detection and prevention, department audits to promote economy and efficiency, and policy recommendations. An informational statement covering his background, financial disclosure, and correspondence follows Mr. Dellinger's testimony. (DCK)

  17. Madness and Rulers: Events in Coorg and London in 1810, as observed by the Hon. Arthur Cole, the resident at Mysore

    PubMed Central

    Jain, Sanjeev; Sarin, Alok

    2015-01-01

    What happens if a King becomes mentally ill? Excerpts from the personal papers of Arthur Henry Cole, Resident to the Kingdom of Mysore in 1809, open up fascinating insights into the madness of rulers, in neighboring Coorg and faraway London, and ways in which different societies responded to this. Musings on legal capacity and restrictions imposed on account of insanity, as well as migration and ennui in imperial colonies inevitably follow. PMID:26124533

  18. Madness and Rulers: Events in Coorg and London in 1810, as observed by the Hon. Arthur Cole, the resident at Mysore.

    PubMed

    Jain, Sanjeev; Sarin, Alok

    2015-01-01

    What happens if a King becomes mentally ill? Excerpts from the personal papers of Arthur Henry Cole, Resident to the Kingdom of Mysore in 1809, open up fascinating insights into the madness of rulers, in neighboring Coorg and faraway London, and ways in which different societies responded to this. Musings on legal capacity and restrictions imposed on account of insanity, as well as migration and ennui in imperial colonies inevitably follow. PMID:26124533

  19. Hypervelocity impact flash for missile-defense kill assessment and engagement analysis : experiments on Z.

    SciTech Connect

    Thornhill, Tom Finley, III; Reinhart, William Dodd; Lawrence, Raymond Jeffery Jr.; Chhabildas, Lalit Chandra; Kelly, Daniel P.

    2005-07-01

    Kill assessment continues to be a major problem for the nation's missile defense program. A potential approach for addressing this issue involves spectral and temporal analysis of the short-time impact flash that occurs when a kill vehicle intercepts and engages a target missile. This can provide identification of the materials involved in the impact event, which will, in turn, yield the data necessary for target identification, engagement analysis, and kill assessment. This report describes the first phases of a project under which we are providing laboratory demonstrations of the feasibility and effectiveness of this approach. We are using two major Sandia facilities, the Z-Pinch accelerator, and the two- and three-stage gas guns at the Shock Thermodynamics and Applied Research (STAR) facility. We have looked at the spectral content of impact flash at velocities up to 25 km/s on the Z-Pinch machine to establish the capability for spectroscopy for these types of events, and are looking at similar experiments at velocities from 6 to 11 km/s on the gas guns to demonstrate a similar capability for a variety of research-oriented and applied materials. The present report describes only the work performed on the Z machine.

  20. Symmetry operators of Killing spinors and superalgebras in AdS5

    NASA Astrophysics Data System (ADS)

    Ertem, Ümit

    2016-04-01

    We construct the first-order symmetry operators of Killing spinor equation in terms of odd Killing-Yano forms. By modifying the Schouten-Nijenhuis bracket of Killing-Yano forms, we show that the symmetry operators of Killing spinors close into an algebra in AdS5 spacetime. Since the symmetry operator algebra of Killing spinors corresponds to a Jacobi identity in extended Killing superalgebras, we investigate the possible extensions of Killing superalgebras to include higher-degree Killing-Yano forms. We found that there is a superalgebra extension but no Lie superalgebra extension of the Killing superalgebra constructed out of Killing spinors and odd Killing-Yano forms in AdS5 background.

  1. Toward a Pragmatist Epistemology: Arthur O. Lovejoy's and H. S. Jennings's Biophilosophical Responses to Neovitalism, 1909-1914.

    PubMed

    Russell, Doug

    2015-01-01

    The sustained interdisciplinary debate about neovitalism between two Johns Hopkins University colleagues, philosopher Arthur O. Lovejoy and experimental geneticist H. S. Jennings, in the period 1911-1914, was the basis for their theoretical reconceptualization of scientific knowledge as contingent and necessarily incomplete in its account of nature. Their response to Hans Driesch's neovitalist concept of entelechy, and his challenge to the continuity between biology and the inorganic sciences, resulted in a historically significant articulation of genetics and philosophy. This study traces the debate's shift of problem-focus away from neovitalism's threat to the unity of science - "organic autonomy," as Lovejoy put it - and toward the potential for development of a nonmechanististic, nonrationalist theory of scientific knowledge. The result was a new pragmatist epistemology, based on Lovejoy's and Jennings's critiques of the inadequacy of pragmatism's account of scientific knowledge. The first intellectual move, drawing on naturalism and pragmatism, was based on a reinterpretation of science as organized experience. The second, sparked by Henri Bergson's theory of creative evolution, and drawing together elements of Dewey's and James's pragmatisms, produced a new account of the contingency and necessary incompleteness of scientific knowledge. Prompted by the neovitalists' mix of a priori concepts and, in Driesch's case, and adherence to empiricism, Lovejoy's and Jennings's developing pragmatist epistemologies of science explored the interrelation between rationalism and empiricism. PMID:25099169

  2. The results of the in-flight attitude sensor calibration for the Arthur Holly Compton Gamma Ray Observatory

    NASA Technical Reports Server (NTRS)

    Davis, W. S.; Eudell, A. H.; Kulp, L. S.; Lindrose, L. A.; Harman, R. R.

    1993-01-01

    The Arthur Holly Compton Gamma Ray Observatory (GRO) was launched by the shuttle Atlantis in April 1991. This paper presents the results of the attitude sensor calibration that was performed during the early mission. The GSFC Flight Dynamics Facility (FDF) performed an alignment calibration of the two fixed-head star trackers (FHST's) and two fine Sun sensors (FSS's) on board Compton GRO. The results show a 27-arcsecond shift between the bore sights of the FHST's with respect to prelaunch measurements. The alignments of the two FSS's shifted by 0.20 and 0.05 degree. During the same time period, the Compton GRO science teams performed an alignment calibration of the science instruments with respect to the attitude reported by the on board computer (OBC). In order to preserve these science alignments, FDF adjusted the overall alignments of the FHST's and FSS's, obtained by the FDF calibration, such that when up linked to the OBC, the shift in the OBC-determined attitude is minimized. FDF also calibrated the inertial reference unit (IRU), which consists of three dual-axis gyroscopes. The observed gyro bias matched the bias that was solved for by the OBC. This bias drifted during the first 6 days after release. The results of the FDF calibration of scale factor and alignment shifts showed changes that were of the same order as their uncertainties.

  3. Observations of Ha Line Profiles in Be Stars Using 45 cm Cassegrain Telescope at Arthur C Clarke Institute

    NASA Astrophysics Data System (ADS)

    Gunasekera, S.; Adassuriya, J.; Medagangoda, N. I.

    2008-12-01

    H-alpha line profiles of 13 Be starts (mv d6.9) were observed using 45 cm Cassegrain telescope at the Arthur C Clarke Institute, Sri Lanka during the period of August 2005 to March 2006. High resolution spectra of these Be stars were obtained using 1200 lines/mm reflective grating in first order with resolution R=λ/Δλ=76800 and linear spectral dispersion 0.31 Å per pixel at 6563 Å in order to find out line parameters such as equivalent width, full width at half-maxima, V/R ratios etc. A study of the correlations between different pairs of parameters was obtained and compared with previous analysis to see the behavior of circumstellar disk. We found a good correlation (0.8) between FWHM and v sin i and strong correlation (0.96) between the Ip/Ic and the equivalent width. The drastic changes of the V/R ratio in profiles HR5941 and HR6712 imply the circumstellar disk is more likely an elliptical shape and undergoes slow apsidal motion. The inclination angles (i) were estimated for each star using the theoretical vsin i values and assuming star rotates in 0.8Vc and are matched with the structure of the line profiles.

  4. Dispersal-induced synchrony, temporal stability, and clustering in a mean-field coupled Rosenzweig-MacArthur model

    NASA Astrophysics Data System (ADS)

    Arumugam, Ramesh; Dutta, Partha Sharathi; Banerjee, Tanmoy

    2015-10-01

    In spatial ecology, dispersal among a set of spatially separated habitats, named as metapopulation, preserves the diversity and persistence by interconnecting the local populations. Understanding the effects of several variants of dispersion in metapopulation dynamics and to identify the factors which promote population synchrony and population stability are important in ecology. In this paper, we consider the mean-field dispersion among the habitats in a network and study the collective dynamics of the spatially extended system. Using the Rosenzweig-MacArthur model for individual patches, we show that the population synchrony and temporal stability, which are believed to be of conflicting outcomes of dispersion, can be simultaneously achieved by oscillation quenching mechanisms. Particularly, we explore the more natural coupling configuration where the rates of dispersal of different habitats are disparate. We show that asymmetry in dispersal rate plays a crucial role in determining inhomogeneity in an otherwise homogeneous metapopulation. We further identify an unusual emergent state in the network, namely, a multi-branch clustered inhomogeneous steady state, which arises due to the intrinsic parameter mismatch among the patches. We believe that the present study will shed light on the cooperative behavior of spatially structured ecosystems.

  5. Dispersal-induced synchrony, temporal stability, and clustering in a mean-field coupled Rosenzweig-MacArthur model.

    PubMed

    Arumugam, Ramesh; Dutta, Partha Sharathi; Banerjee, Tanmoy

    2015-10-01

    In spatial ecology, dispersal among a set of spatially separated habitats, named as metapopulation, preserves the diversity and persistence by interconnecting the local populations. Understanding the effects of several variants of dispersion in metapopulation dynamics and to identify the factors which promote population synchrony and population stability are important in ecology. In this paper, we consider the mean-field dispersion among the habitats in a network and study the collective dynamics of the spatially extended system. Using the Rosenzweig-MacArthur model for individual patches, we show that the population synchrony and temporal stability, which are believed to be of conflicting outcomes of dispersion, can be simultaneously achieved by oscillation quenching mechanisms. Particularly, we explore the more natural coupling configuration where the rates of dispersal of different habitats are disparate. We show that asymmetry in dispersal rate plays a crucial role in determining inhomogeneity in an otherwise homogeneous metapopulation. We further identify an unusual emergent state in the network, namely, a multi-branch clustered inhomogeneous steady state, which arises due to the intrinsic parameter mismatch among the patches. We believe that the present study will shed light on the cooperative behavior of spatially structured ecosystems. PMID:26520087

  6. The results of the in-flight attitude sensor calibration for the Arthur Holly Compton Gamma Ray Observatory

    NASA Astrophysics Data System (ADS)

    Davis, W. S.; Eudell, A. H.; Kulp, L. S.; Lindrose, L. A.; Harman, R. R.

    1993-02-01

    The Arthur Holly Compton Gamma Ray Observatory (GRO) was launched by the shuttle Atlantis in April 1991. This paper presents the results of the attitude sensor calibration that was performed during the early mission. The GSFC Flight Dynamics Facility (FDF) performed an alignment calibration of the two fixed-head star trackers (FHST's) and two fine Sun sensors (FSS's) on board Compton GRO. The results show a 27-arcsecond shift between the bore sights of the FHST's with respect to prelaunch measurements. The alignments of the two FSS's shifted by 0.20 and 0.05 degree. During the same time period, the Compton GRO science teams performed an alignment calibration of the science instruments with respect to the attitude reported by the on board computer (OBC). In order to preserve these science alignments, FDF adjusted the overall alignments of the FHST's and FSS's, obtained by the FDF calibration, such that when up linked to the OBC, the shift in the OBC-determined attitude is minimized. FDF also calibrated the inertial reference unit (IRU), which consists of three dual-axis gyroscopes. The observed gyro bias matched the bias that was solved for by the OBC. This bias drifted during the first 6 days after release. The results of the FDF calibration of scale factor and alignment shifts showed changes that were of the same order as their uncertainties.

  7. [Carl Arthur Scheunert's experiments on human nutrition, 1938-1943: boundary transgressions of a scientist under national socialism].

    PubMed

    Joost, Hans-Georg

    2012-01-01

    Carl Arthur Scheunert (1879-1957) was a German scientist who supervised several studies with prisoners that were designed to assess the optimal vitamin and nutrient supply, and were conducted by his associate Karl-Heinz Wagner (1911-2007) from 1938 to 1943. This contribution describes the aims, results and conclusions of Scheunert's research 1923 to 1945 in comparison with the national and international vitamin research and its consequences for public health measures. Conditions and results of the human experiments are reconstructed and compared with similar studies performed in other countries. Burden as well as health risks for the study participants are assessed. In addition, it is discussed whether general rules for human experimentation were followed (e.g. informed consent and minimizing of health risks). Although the available documents support the conclusion that no deaths or lasting injuries were caused, the experiments violated ethical standards, in particular because of the conditions in the Waldheim prison including progressive deterioration of nutrition and health. PMID:24380261

  8. Arthur Conan Doyle (1859-1930): Physician during the typhoid epidemic in the Anglo-Boer War (1899-1902).

    PubMed

    Cirillo, Vincent J

    2014-02-01

    When the Anglo-Boer War broke out in October 1899, Arthur Conan Doyle, a retired ophthalmologist, was already famous as the creator of Sherlock Holmes. Motivated by patriotism and adventure, Doyle joined the medical staff of a private field hospital endowed by philanthropist John Langman (1846-1928). Langman Hospital opened in Bloemfontein, South Africa, at the height of that city's typhoid fever epidemic which raged from April to June 1900. There were nearly 5000 cases of typhoid and 1000 deaths but official statistics do not truly reflect the magnitude of the suffering. Doyle argued that the British Army had made a major mistake by not making antityphoid inoculation compulsory. Because of the new vaccine's side effects, 95% of the soldiers refused immunization. Despite his strong opinions, Doyle failed to press the issue of compulsory inoculation when he testified before two Royal Commissions investigating the medical and military management of the war in South Africa. One can only imagine how the army might have benefited from the new idea of prophylactic vaccination in preventive medicine if Doyle had not let these opportunities slip away. As a consequence, antityphoid inoculation was still voluntary when Great Britain entered World War I in August 1914. PMID:24585840

  9. Arthur Simons (1877-1942) and Tonic Neck Reflexes With Hemiplegic "Mitbewegungen" (Associated Reactions): Cinematography From 1916-1919.

    PubMed

    Holdorff, Bernd

    2016-01-01

    Tonic neck reflexes were investigated by Rudolf Magnus and Adriaan de Kleijn in animals and men in 1912 and eventually by Arthur Simons, a neurologist in Berlin and coworker of Hermann Oppenheim. Simons studied these reflexes in hemiplegic patients, who were mainly victims of World War I. This work became his most important contribution and remained unsurpassed for many years. The film (Filmarchiv, Bundesarchiv [Film Archive, National Archive] Berlin) with Simons as an examiner shows 11 war casualties with brain lesions that occurred between 1916 and 1919. The injuries reveal asymmetric neck reflexes with "Mitbewegungen," that is, flexion or extension on the hemiplegic side. Mitbewegungen is identical with Francis Walshe's "associated reactions" caused by neck rotation and/or by cocontraction of the nonaffected extremities, for example, by closing of the fist (Walshe). The knowledge of the neck reflexes is important in acute neurology and in rehabilitation therapy of hemiplegics for antispastic positions. Simons' investigations were conducted in the early era of increasing use of cinematography in medical studies. The film had been nearly forgotten until its rediscovery in 2010. PMID:26684424

  10. Chemo killed the small-talk gene.

    PubMed

    Vaid, Urvashi

    2014-01-01

    Urvashi Vaid is a community organizer and writer active in the lesbian, gay, bisexual, and transgender (LGBT) and social justice movements for over three decades. She is currently Director of the Engaging Tradition Project at the Center for Gender and Sexuality Law at Columbia University Law School. She is founder of LPAC, the first lesbian political action committee, and sits on the Board of Directors of the Gill Foundation. Vaid's past positions include Executive Director of the Arcus Foundation, Deputy Director of Governance and Civil Society Unit for the Ford Foundation, Executive Director of the National Gay and Lesbian Task Force, and staff attorney for the ACLU National Prison Project. She is author of the books Irresistible Revolution: Confronting Race, Class and The Assumptions of Lesbian, Gay, Bisexual, and Transgender Politics, and Virtual Equality: The Mainstreaming of Gay & Lesbian Liberation, and co-editor of the book Creating Change: Public Policy, Sexuality and Civil Rights. Urvashi has had thyroid cancer and stage III breast cancer. PMID:24400627

  11. Prairie dogs increase fitness by killing interspecific competitors.

    PubMed

    Hoogland, John L; Brown, Charles R

    2016-03-30

    Interspecific competition commonly selects for divergence in ecology, morphology or physiology, but direct observation of interspecific competition under natural conditions is difficult. Herbivorous white-tailed prairie dogs (Cynomys leucurus) employ an unusual strategy to reduce interspecific competition: they kill, but do not consume, herbivorous Wyoming ground squirrels (Urocitellus elegans) encountered in the prairie dog territories. Results from a 6-year study in Colorado, USA, revealed that interspecific killing of ground squirrels by prairie dogs was common, involving 47 different killers; 19 prairie dogs were serial killers in the same or consecutive years, and 30% of female prairie dogs killed at least one ground squirrel over their lifetimes. Females that killed ground squirrels had significantly higher annual and lifetime fitness than non-killers, probably because of decreased interspecific competition for vegetation. Our results document the first case of interspecific killing of competing individuals unrelated to predation (IK) among herbivorous mammals in the wild, and show that IK enhances fitness for animals living under natural conditions. PMID:27009223

  12. Honor killing attitudes amongst adolescents in Amman, Jordan.

    PubMed

    Eisner, Manuel; Ghuneim, Lana

    2013-01-01

    The present study examines attitudes towards honor crimes amongst a sample of 856 ninth grade students (mean age = 14.6, SD = 0.56) from 14 schools in Amman, Jordan. Descriptive findings suggest that about 40% of boys and 20% of girls believe that killing a daughter, sister, or wife who has dishonored the family can be justified. A number of theoretically meaningful predictors were examined: Findings suggest that attitudes in support of honor killings are more likely amongst adolescents who have collectivist and patriarchal world views, believe in the importance of female chastity amongst adolescents, and morally neutralize aggressive behavior in general. Findings for parental harsh discipline are mixed: While the father's harsh discipline is predictive of honor killing attitudes, the mother's behavior is not. Furthermore, support for honor killing is stronger amongst male adolescents and adolescents for low education backgrounds. After controlling for other factors religion and the intensity of religious beliefs are not associated with support for honor killings. Models were tested separately for male and female respondents and suggested no systematic differences in predictors. Limitations and implications are discussed. PMID:23744567

  13. Inflatable kill packers used in working over Kuwaiti wells

    SciTech Connect

    Miller, D. ); Conover, G. )

    1992-03-09

    This paper reports on inflatable packers which are being used with great success in post-well capping workover operations in Kuwait oil fields. In mid-January, about one kill packer was being run per day. Use is expected to increase in March when a second post-capping crew arrives. Of several thousand unconventional ideas submitted to Kuwait Oil Co. (KOC) for controlling the well fires left in the aftermath of lst year's Gulf War, only about a dozen were actually used. Inflatable kill packers, designed and manufactured by Baker Service Tools and marketed by Baker Oil Tools, were one of the ideas that proved effective. The kill packers are modifications of Baker's inflatable packers that have successfully been used in capping producers on many blowouts throughout the world, including the Piper Alpha disaster in the North Sea and the Saga blowout offshore Norway.

  14. Reactive oxygen species-mediated bacterial killing by B lymphocytes.

    PubMed

    Kovács, István; Horváth, Magdolna; Lányi, Árpád; Petheő, Gábor L; Geiszt, Miklós

    2015-06-01

    Regulated production of ROS is mainly attributed to Nox family enzymes. In neutrophil granulocytes and macrophages, Nox2 has a crucial role in bacterial killing, and the absence of phagocytic ROS production leads to the development of CGD. Expression of Nox2 was also described in B lymphocytes, where the role of the enzyme is still poorly understood. Here, we show that peritoneal B cells, which were shown recently to possess phagocytic activity, have a high capacity to produce ROS in a Nox2-dependent manner. In phagocytosing B cells, intense intraphagosomal ROS production is detected. Finally, by studying 2 animal models of CGD, we demonstrate that phagocyte oxidase-deficient B cells have a reduced capacity to kill bacteria. Our observations extend the number of immune cell types that produce ROS to kill pathogens. PMID:25821233

  15. DNA damage and cell killing. Cause and effect

    SciTech Connect

    Elkind, M.M.

    1985-11-15

    The evidence supporting a cause and effect relationship between DNA damage and cell killing is examined in the light of what is currently known about the organization and replication of genomic DNA in eukaryotic cells and the radio-energetics of DNA breakage. A large disparity is identified between characteristic doses for cell killing and for the production of DNA lesions (i.e., single- or double-strand breaks). In contrast, the sensitive phase of the inhibition of DNA synthesis has a dependence on dose quantitatively similar to that of cell killing. A model is developed in which single- and double-strand breaks are associated with the inhibition of replicon initiation, whereas only double-strand breaks are primarily responsible for strand elongation. Furthermore, the model points to the replisome and the region of replicated DNA just downstream from the fork as the locus of radiation action.

  16. Almost-Killing conserved currents: A general mass function

    NASA Astrophysics Data System (ADS)

    Ruiz, Milton; Palenzuela, Carlos; Bona, Carles

    2014-01-01

    A new class of conserved currents, describing nongravitational energy-momentum density, is presented. The proposed currents do not require the existence of a (timelike) Killing vector, and are not restricted to spherically symmetric spacetimes (or similar ones, in which the Kodama vector can be defined). They are based instead on almost-Killing vectors, which could in principle be defined on generic spacetimes. We provide local arguments, based on energy density profiles in highly simplified (stationary, rigidly rotating) star models, which confirm the physical interest of these almost-Killing currents. A mass function is defined in this way for the spherical case, qualitatively different from the Hernández-Misner mass function. An elliptic equation determining the new mass function is derived for the Tolman-Bondi spherically symmetric dust metrics, including a simple solution for the Oppenheimer-Snyder collapse. The equations for the nonsymmetric case are shown to be of a mixed elliptic-hyperbolic nature.

  17. QFT on homothetic Killing twist deformed curved spacetimes

    NASA Astrophysics Data System (ADS)

    Schenkel, Alexander

    2011-10-01

    We study the quantum field theory (QFT) of a free, real, massless and curvature coupled scalar field on self-similar symmetric spacetimes, which are deformed by an abelian Drinfel'd twist constructed from a Killing and a homothetic Killing vector field. In contrast to deformations solely by Killing vector fields, such as the Moyal-Weyl Minkowski spacetime, the equation of motion and Green's operators are deformed. We show that there is a *-algebra isomorphism between the QFT on the deformed and the formal power series extension of the QFT on the undeformed spacetime. We study the convergent implementation of our deformations for toy-models. For these models it is found that there is a *-isomorphism between the deformed Weyl algebra and a reduced undeformed Weyl algebra, where certain strongly localized observables are excluded. Thus, our models realize the intuitive physical picture that noncommutative geometry prevents arbitrary localization in spacetime.

  18. Killing and Noether Symmetries of Plane Symmetric Spacetime

    NASA Astrophysics Data System (ADS)

    Shamir, M. Farasat; Jhangeer, Adil; Bhatti, Akhlaq Ahmad

    2013-09-01

    This paper is devoted to investigate the Killing and Noether symmetries of static plane symmetric spacetime. For this purpose, five different cases have been discussed. The Killing and Noether symmetries of Minkowski spacetime in cartesian coordinates are calculated as a special case and it is found that Lie algebra of the Lagrangian is 10 and 17 dimensional respectively. The symmetries of Taub's universe, anti-deSitter universe, self similar solutions of infinite kind for parallel perfect fluid case and self similar solutions of infinite kind for parallel dust case are also explored. In all the cases, the Noether generators are calculated in the presence of gauge term. All these examples justify the conjecture that Killing symmetries form a subalgebra of Noether symmetries (Bokhari et al. in Int. J. Theor. Phys. 45:1063, 2006).

  19. Humane killing of animals for disease control purposes.

    PubMed

    Thornber, P M; Rubira, R J; Styles, D K

    2014-04-01

    Killing for disease control purposes is an emotional issue for everyone concerned. Large-scale euthanasia or depopulation of animals may be necessary for the emergency control or eradication of animal diseases, to remove animals from a compromised situation (e.g. following flood, storm, fire, drought or a feed contamination event), to effect welfare depopulation when there is an oversupply due to a dysfunctional or closed marketing channel, or to depopulate and dispose of animals with minimal handling to decrease the risk of a zoonotic disease infecting humans. The World Organisation for Animal Health (OIE) developed international standards to provide advice on humane killing for various species and situations. Some fundamental issues are defined, such as competency of animal handling and implementation of humane killing techniques. Some of these methods have been used for many years, but novel approaches for the mass killing of particular species are being explored. Novel vaccines and new diagnostic techniques that differentiate between vaccinated and infected animals will save many animals from being killed as part of biosecurity response measures. Unfortunately, the destruction of affected livestock will still be required to control diseases whilst vaccination programmes are activated or where effective vaccines are not available. This paper reviews the principles of humane destruction and depopulation and explores available techniques with their associated advantages and disadvantages. It also identifies some current issues that merit consideration, such as legislative conflicts (emergency disease legislation versus animal welfare legislation, occupational health and safety), media issues, opinions on the future approaches to killing for disease control, and animal welfare. PMID:25000803

  20. Binding and killing of bacteria by bismuth subsalicylate.

    PubMed Central

    Sox, T E; Olson, C A

    1989-01-01

    Bismuth subsalicylate (BSS) is a compound without significant aqueous solubility that is widely used for the treatment of gastrointestinal disorders. BSS was able to bind bacteria of diverse species, and these bound bacteria were subsequently killed. A 4-log10 reduction of viable bacteria occurred within 4 h after a 10 mM aqueous suspension of BSS was inoculated with 2 x 10(6) Escherichia coli cells per ml. Binding and killing were dependent on the levels of inoculated bacteria, and significant binding but little killing of the exposed bacteria occurred at an inoculum level of 2 x 10(9) E. coli per ml. Intracellular ATP decreased rapidly after exposure of E. coli to 10 mM BSS and, after 30 min, was only 1% of the original level. Extracellular ATP increased after exposure to BSS, but the accumulation of extracellular ATP was not sufficient to account for the loss of intracellular ATP. The killing of bacteria exposed to BSS may have been due to cessation of ATP synthesis or a loss of membrane integrity. Bactericidal activity of BSS was also investigated in a simulated gastric juice at pH 3. Killing of E. coli at this pH was much more rapid than at pH 7 and was apparently due to salicylate released by the conversion of BSS to bismuth oxychloride. It is proposed that the binding and killing observed for BSS contribute to the efficacy of this compound against gastrointestinal infections such as traveler's diarrhea. PMID:2694949

  1. The enigma of the Arthur's Pass, New Zealand, earthquake 1. Reconciling a variety of data for an unusual earthquake sequence

    USGS Publications Warehouse

    Abercrombie, R.E.; Webb, T.H.; Robinson, R.; McGinty, P.J.; Mori, J.J.; Beavan, R.J.

    2000-01-01

    The 1994 Arthur's Pass earthquake (Mw6.7) is the largest in a recent sequence of earthquakes in the central South Island, New Zealand. No surface rupture was observed the aftershock distribution was complex, and routine methods of obtaining the faulting orientation of this earthquake proved contradictory. We use a range of data and techniques to obtain our preferred solution, which has a centroid depth of 5 km, Mo=1.3??1019 N m, and a strike, dip, and rake of 221??, 47??, 112??, respectively. Discrepancies between this solution and the Harvard centroid moment tensor, together with the Global Positioning System (GPS) observations and unusual aftershock distribution, suggest that the rupture may not have occurred on a planar fault. A second, strike slip, subevent on a more northerly striking plane is suggested by these data but neither the body wave modeling nor regional broadband recordings show any complexity or late subevents. We relocate the aftershocks using both one-dimensional and three-dimensional velocity inversions. The depth range of the aftershocks (1-10 km) agrees well with the preferred mainshock centroid depth. The aftershocks near the hypocenter suggest a structure dipping toward the NW, which we interpret to be the mainshock fault plane. This structure and the Harper fault, ???15 km to the south appear to have acted as boundaries to the extensive aftershock zone trending NNW-SSE Most of the ML???5 aftershocks, including the two largest (ML6.1 and ML5.7), clustered near the Harper fault and have strike slip mechanisms consistent with motion on this fault and its conjugates. Forward modeling of the GPS data suggests that a reverse slip mainshock, combined with strike slip aftershock faulting in the south, is able to match the observed displacements. The occurrence of this earthquake sequence implies that the level of seismic hazard in the central South Island is greater than previous estimates. Copyright 2000 by the American Geophysical Union.

  2. Cars kill chimpanzees: case report of a wild chimpanzee killed on a road at Bulindi, Uganda.

    PubMed

    McLennan, Matthew R; Asiimwe, Caroline

    2016-07-01

    Roads have broadly adverse impacts on wildlife, including nonhuman primates. One direct effect is mortality from collisions with vehicles. While highly undesirable, roadkills provide valuable information on the health and condition of endangered species. We present a case report of a wild chimpanzee (Pan troglodytes schweinfurthii) killed crossing a road in Bulindi, Uganda, where chimpanzees inhabit forest fragments amid farmland. Details of the collision are constructed from eyewitness accounts of pedestrians. Physical examination of the cadaver indicated good overall body condition; at 40 kg, the deceased female was heavier than usual for an adult female East African chimpanzee. No external wounds or fractures were noted. Coprological assessment demonstrated infection by several gastrointestinal parasites commonly reported in living wild chimpanzees. Histopathology revealed eosinophilic enteritis and biliary hyperplasia potentially caused by parasite infection. However, eosinophilia was not widely spread into the submucosa, while egg/cyst counts suggested low-intensity parasite infections compared to healthy female chimpanzees of similar age in nearby Budongo Forest. No behavioral indicators of ill health were noted in the deceased female in the month prior to the accident. We conclude that cause of death was acute, i.e., shock from the collision, and was probably unrelated to parasite infection or any other underlying health condition. Notably, this female had asymmetrical polythelia, and, while nursing at the time of her death, had one functioning mammary gland only. In Uganda, where primates often inhabit human-dominated landscapes, human population growth and economic development has given rise to increasing motor traffic, while road development is enabling motorists to travel at greater speeds. Thus, the danger of roads to apes and other wildlife is rising, necessitating urgent strategies to reduce risks. Installation of simple speed-bumps-common on Ugandan

  3. What Is John Dewey Doing in "To Kill a Mockingbird"?

    ERIC Educational Resources Information Center

    Frank, Jeff

    2015-01-01

    Harper Lee's novel "To Kill a Mockingbird" is taught in countless public schools and is beloved by many teachers and future teachers. Embedded within this novel--interestingly--is a strong criticism of an approach to education mockingly referred to as the "Dewey Decimal System." In this essay I explore Lee's criticism of…

  4. 22. New York Connecting Railroad: Bronx Kill Bridge. Randalls Island, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. New York Connecting Railroad: Bronx Kill Bridge. Randalls Island, New York Co., NY. Sec. 4207, MP 8.54. - Northeast Railroad Corridor, Amtrak Route between New Jersey/New York & New York/Connecticut State Lines, New York County, NY

  5. 21. New York Connecting Railroad: Bronx Kill Bridge. Randalls Island, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. New York Connecting Railroad: Bronx Kill Bridge. Randalls Island, New York Co., NY. Sec. 4207, MP 8.54. - Northeast Railroad Corridor, Amtrak Route between New Jersey/New York & New York/Connecticut State Lines, New York County, NY

  6. Illegal killing for ivory drives global decline in African elephants.

    PubMed

    Wittemyer, George; Northrup, Joseph M; Blanc, Julian; Douglas-Hamilton, Iain; Omondi, Patrick; Burnham, Kenneth P

    2014-09-01

    Illegal wildlife trade has reached alarming levels globally, extirpating populations of commercially valuable species. As a driver of biodiversity loss, quantifying illegal harvest is essential for conservation and sociopolitical affairs but notoriously difficult. Here we combine field-based carcass monitoring with fine-scale demographic data from an intensively studied wild African elephant population in Samburu, Kenya, to partition mortality into natural and illegal causes. We then expand our analytical framework to model illegal killing rates and population trends of elephants at regional and continental scales using carcass data collected by a Convention on International Trade in Endangered Species program. At the intensively monitored site, illegal killing increased markedly after 2008 and was correlated strongly with the local black market ivory price and increased seizures of ivory destined for China. More broadly, results from application to continental data indicated illegal killing levels were unsustainable for the species between 2010 and 2012, peaking to ∼ 8% in 2011 which extrapolates to ∼ 40,000 elephants illegally killed and a probable species reduction of ∼ 3% that year. Preliminary data from 2013 indicate overharvesting continued. In contrast to the rest of Africa, our analysis corroborates that Central African forest elephants experienced decline throughout the last decade. These results provide the most comprehensive assessment of illegal ivory harvest to date and confirm that current ivory consumption is not sustainable. Further, our approach provides a powerful basis to determine cryptic mortality and gain understanding of the demography of at-risk species. PMID:25136107

  7. Strength in Numbers: Visualizing CTL-Mediated Killing In Vivo.

    PubMed

    Nolz, Jeffrey C; Hill, Ann B

    2016-02-16

    Cytotoxic CD8+ T lymphocytes (CTLs) have long been believed to be extremely efficient killers. Forster and colleagues (Halle et al., 2016) used in vivo imaging to tell a different story, in which each CTL killed only 2-16 targets a day, and several CTLs per target were needed to get the job done. PMID:26885849

  8. Illegal killing for ivory drives global decline in African elephants

    PubMed Central

    Wittemyer, George; Northrup, Joseph M.; Blanc, Julian; Douglas-Hamilton, Iain; Omondi, Patrick; Burnham, Kenneth P.

    2014-01-01

    Illegal wildlife trade has reached alarming levels globally, extirpating populations of commercially valuable species. As a driver of biodiversity loss, quantifying illegal harvest is essential for conservation and sociopolitical affairs but notoriously difficult. Here we combine field-based carcass monitoring with fine-scale demographic data from an intensively studied wild African elephant population in Samburu, Kenya, to partition mortality into natural and illegal causes. We then expand our analytical framework to model illegal killing rates and population trends of elephants at regional and continental scales using carcass data collected by a Convention on International Trade in Endangered Species program. At the intensively monitored site, illegal killing increased markedly after 2008 and was correlated strongly with the local black market ivory price and increased seizures of ivory destined for China. More broadly, results from application to continental data indicated illegal killing levels were unsustainable for the species between 2010 and 2012, peaking to ∼8% in 2011 which extrapolates to ∼40,000 elephants illegally killed and a probable species reduction of ∼3% that year. Preliminary data from 2013 indicate overharvesting continued. In contrast to the rest of Africa, our analysis corroborates that Central African forest elephants experienced decline throughout the last decade. These results provide the most comprehensive assessment of illegal ivory harvest to date and confirm that current ivory consumption is not sustainable. Further, our approach provides a powerful basis to determine cryptic mortality and gain understanding of the demography of at-risk species. PMID:25136107

  9. Diphtheria toxin mutant selectively kills cerebellar Purkinje neurons.

    PubMed Central

    Riedel, C J; Muraszko, K M; Youle, R J

    1990-01-01

    CRM107 (crossreacting material 107), a double point mutant of diphtheria toxin that lacks receptor-binding activity, specifically kills cerebellar Purkinje cells in vivo. After injection into guinea pig cerebrospinal fluid, CRM107 (0.9 micrograms) and CRM107-monoclonal antibody conjugates (10 micrograms) kill up to 90% of the total Purkinje cell population with no detectable toxicity to other neurons. Animals exhibit ataxia, tremor, and abnormalities of posture and tone. Native diphtheria toxin, ricin, and ricin A chain do not cause ataxia and do not reduce the Purkinje cell population after intrathecal injection into guinea pigs at toxic or maximally tolerated doses. However, in rats, which will tolerate higher doses of diphtheria toxin than guinea pigs, Purkinje cells can be killed by both CRM107 and diphtheria toxin. A truncated mutant of diphtheria toxin, called CRM45, can also cause Purkinje cell killing but has additional toxicity not seen with CRM107. Animals treated with intrathecal CRM107 or CRM107 linked to antibodies may serve as models for Purkinje cell loss in a broad spectrum of human diseases and may be used to further study cerebellar physiology. Understanding the basis for the Purkinje cell sensitivity to CRM107 may illuminate other causes of Purkinje cell loss. Images PMID:2367523

  10. Pseudomonas Exotoxin A: optimized by evolution for effective killing

    PubMed Central

    Michalska, Marta; Wolf, Philipp

    2015-01-01

    Pseudomonas Exotoxin A (PE) is the most toxic virulence factor of the pathogenic bacterium Pseudomonas aeruginosa. This review describes current knowledge about the intoxication pathways of PE. Moreover, PE represents a remarkable example for pathoadaptive evolution, how bacterial molecules have been structurally and functionally optimized under evolutionary pressure to effectively impair and kill their host cells. PMID:26441897

  11. Karo-kari: a form of honour killing in pakistan.

    PubMed

    Patel, Sujay; Gadit, Amin Muhammad

    2008-12-01

    Karo-Kari is a type of premeditated honour killing, which originated in rural and tribal areas of Sindh, Pakistan. The homicidal acts are primarily committed against women who are thought to have brought dishonour to their family by engaging in illicit pre-marital or extra-marital relations. In order to restore this honour, a male family member must kill the female in question. We conducted a systematic review of the published literature other sources on karo-kari and related forms of honour killing or violence against women. Media and non-governmental organization reports were utilized for case studies and analysis. Although legally proscribed, socio-cultural factors and gender role expectations have given legitimacy to karo-kari within some tribal communities. In addition to its persistence in areas of Pakistan, there is evidence that karo-kari may be increasing in incidence in other parts of the world in association with migration. Moreover, perpetrators of ;honour killings' often have motives outside of female adultery. Analysis of the socio-cultural and psycho-pathological factors associated with the practice of karo-kari can guide the development of prevention strategies. PMID:19091732

  12. Killing for Girls: Predation Play and Female Empowerment

    ERIC Educational Resources Information Center

    Bertozzi, Elena

    2012-01-01

    Predation games--games in which the player is actively encouraged and often required to hunt and kill in order to survive--have historically been the purview of male players. Females, though now much more involved in digital games than before, generally play games that stress traditionally feminine values such as socializing with others, shopping,…

  13. 20. Bronx Kill Bridge with Hell Gate Bridge in background. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. Bronx Kill Bridge with Hell Gate Bridge in background. Randalls Island, New York Co., NY. Sec. 4207, MP 8.54. - Northeast Railroad Corridor, Amtrak Route between New Jersey/New York & New York/Connecticut State Lines, New York County, NY

  14. The Fish Kill Mystery: Learning about Aquatic Communities

    ERIC Educational Resources Information Center

    Kosal, Erica F.

    2004-01-01

    This paper presents a case where students can learn about aquatic communities. In this case, students speculate on what may have caused a major fish kill in an estuary in North Carolina. In the process, they explore how land runoff and excess nutrients affect aquatic communities. They also learn about the complex life cycle of the dinoflagellate…

  15. Saying the Unsaid: Girl Killing and the Curriculum.

    ERIC Educational Resources Information Center

    Perlstein, Daniel

    1998-01-01

    Although students in Jonesboro, Arkansas, repeatedly claimed that the March 1998 killing of four schoolgirls and a teacher was motivated by a rejected boy's desire for revenge, reporters and authorities dismissed this explanation and gender's role in the crime. Closer analysis suggests opportunities and difficulties for educators who want…

  16. In Vitro Killing of Mycobacterium ulcerans by Acidified Nitrite

    PubMed Central

    Phillips, R.; Kuijper, S.; Benjamin, N.; Wansbrough-Jones, M.; Wilks, M.; Kolk, A. H. J.

    2004-01-01

    Mycobacterium ulcerans, which causes Buruli ulcer, was exposed to acidified nitrite or to acid alone for 10 or 20 min. Killing was rapid, and viable counts were reduced below detectable limits within 10 min of exposure to 40 mM acidified nitrite. M. ulcerans is highly susceptible to acidified nitrite in vitro. PMID:15273132

  17. Patterns of Amphotericin B Killing Kinetics against Seven Candida Species

    PubMed Central

    Cantón, Emilia; Pemán, Javier; Gobernado, Miguel; Viudes, Angel; Espinel-Ingroff, Ana

    2004-01-01

    In a previous study tolerance to amphotericin B (AMB) was found among Candida parapsilosis and C. dubliniensis strains by seeding the whole volumes of wells used for MIC determinations, and minimum fungicidal concentrations (MFC) for non-C. albicans Candida strains were demonstrated to be above the levels safely achievable in serum. As an extension of that study, we performed time-kill assays with 26 blood culture isolates (6 C. albicans, 5 C. parapsilosis, 5 C. krusei, 4 C. glabrata, 3 C. lusitaniae, and 3 C. tropicalis isolates), 3 oropharyngeal C. dubliniensis isolates, 3 AMB-susceptible isolates (ATCC 90028, ATCC 22019, ATCC 6254), and 6 AMB-resistant isolates (ATCC 200955, ATCC 200956, ATCC 200950, ATCC 200951, ATCC 200952, ATCC 200953) using RPMI 1640 medium and 0.12 to 32 μg of AMB per ml and determined the numbers of CFU per milliliter at 0, 2, 4, 8, 12, 24, and 48 h. MFCs and time-kill patterns were species specific (MFCs, ≤1 μg/ml for all C. dubliniensis and C. albicans isolates except AMB-resistant strain ATCC 200955; MFCs, 2 to >16 μg/ml for the other isolates). The times required to reach the fungicidal endpoint (99.9% killing) at four times the MIC were 2 h for C. albicans and C. dubliniensis, 16 h for C. glabrata, 24 h for C. parapsilosis and C. lusitaniae, and ≥40 h for C. tropicalis and C. krusei. The killing rate increased as the AMB concentration was increased up to 2 μg/ml. The highest killing rates were achieved for C. albicans, C. dubliniensis, and C. lusitaniae, while viable C. tropicalis, C. krusei, and C. parapsilosis cells were present after 48 h (MICs, ≤2 μg/ml) when AMB was used at 2 μg/ml. Time-kill curves and MFCs can detect viable cells after 48 h when AMB is used at ≥2 μg/ml. The failure of AMB treatment could be due to its poor killing activity against some species at the concentrations reached in patients' serum. PMID:15215097

  18. Combined effects of lactoferrin and lysozyme on Streptococcus pneumoniae killing.

    PubMed

    André, G O; Politano, W R; Mirza, S; Converso, T R; Ferraz, L F C; Leite, L C C; Darrieux, M

    2015-12-01

    Streptococcus pneumoniae is a common colonizer of the human nasopharynx, which can occasionally spread to sterile sites, causing diseases such as otitis media, sinusitis, pneumonia, meningitis and bacteremia. Human apolactoferrin (ALF) and lysozyme (LZ) are two important components of the mucosal innate immune system, exhibiting lytic effects against a wide range of microorganisms. Since they are found in similar niches of the host, it has been proposed that ALF and LZ could act synergistically in controlling bacterial spread throughout the mucosa. The combination of ALF and LZ has been shown to enhance killing of different pathogens in vitro, with ALF facilitating the latter action of LZ. The aim of the present work was to investigate the combined effects of ALF and LZ on S pneumoniae. Concomitant addition of ALF and LZ had a synergistic killing effect on one of the pneumococci tested. Furthermore, the combination of ALF and ALZ was more bactericidal than lysozyme alone in all pneumococcal strains. Pneumococcal surface protein A (PspA), an important vaccine candidate, partially protects pneumococci from ALF mediated killing, while antibodies against one PspA enhance killing of the homologous strain by ALF. However, the serological variability of this molecule could limit the effect of anti-PspA antibodies on different pneumococci. Therefore, we investigated the ability of anti-PspA antibodies to increase ALF-mediated killing of strains that express different PspAs, and found that antisera to the N-terminal region of PspA were able to increase pneumococcal lysis by ALF, independently of the sequence similarities between the molecule expressed on the bacterial surface and that used to produce the antibodies. LF binding to the pneumococcal surface was confirmed by flow cytometry, and found to be inhibited in presence of anti-PspA antibodies. On a whole, the results suggest a contribution of ALF and LZ to pneumococcal clearance, and confirm PspA's ability to interact

  19. Antithymocyte Globulin at Clinically Relevant Concentrations Kills Leukemic Blasts.

    PubMed

    Dabas, Rosy; Lee, Rachelle; Servito, Maria Theresa; Dharmani-Khan, Poonam; Modi, Monica; van Slyke, Tiffany; Luider, Joanne; Durand, Caylib; Larratt, Loree; Brandwein, Joseph; Morris, Don; Daly, Andrew; Khan, Faisal M; Storek, Jan

    2016-05-01

    In contrast to cyclosporine or methotrexate, rabbit antithymocyte globulin (ATG) used for graft-versus-host disease (GVHD) prophylaxis with myeloablative conditioning does not increase the risk of relapse after hematopoietic cell transplantation. The reason for this is unknown. We hypothesized that ATG at concentrations achieved with our standard ATG dose of 4.5 mg/kg exerts antileukemic activity. We measured ATG-induced killing of leukemic blasts via complement-dependent cytotoxicity (CDC) and via complement-independent cytotoxicity (CIC) in marrow or blood from 36 patients with newly diagnosed acute leukemia. The median percentage of blasts killed by CDC was 0.3% at 1 mg/L ATG, 2.8% at 10 mg/L ATG, 12.6% at 25 mg/L ATG, and 42.2% at 50 mg/L ATG. The median percentage of blasts killed by CIC after a 4-hour incubation with ATG was 1.9% at 1 mg/L ATG, 7.15% at 10 mg/L ATG, 12.1% at 25 mg/L ATG, and 13.9% at 50 mg/L ATG. CIC appeared to represent a direct induction of apoptosis by ATG. There was a high variability in the sensitivity of the blasts to ATG; at 50 mg/L, the percentage of blasts killed ranged from 2.6% to 97.2% via CDC and from 1.4% to 69.9% via CIC. In conclusion, ATG at clinically relevant concentrations kills leukemic blasts in vitro. Some acute leukemias are highly sensitive to ATG, whereas others are relatively resistant. This finding could lead to personalized administration of ATG. PMID:26779931

  20. Does complement kill E. coli by producing transmural pores?

    PubMed Central

    Born, J; Bhakdi, S

    1986-01-01

    Three lines of evidence are presented to indicate that C5b-9 kills serum-sensitive E. coli K 12 cells by generating functional pores across the outer and inner bacterial membrane. First, viable cells carrying C5b-8 complexes are impermeable to o-nitrophenyl-beta-D-galactoside (ONPG), but lose viability and become permeable to this marker upon post-treatment with purified C9 in the absence of lysozyme. Cells killed with colicin E1 or gentamicin are also impermeable to ONPG but take up the marker if they are post-treated with lysozyme-free serum. Second, killing by C5b-9 is highly effective, deposition of only a small number of complexes being lethal. This has been demonstrated in experiments where viable cells carrying 2000-4000 C5b-7 complexes per CFU were permitted to multiply in broth culture, and the daughter generations subsequently treated with purified C8 and C9. Fifty percent killing was observed in the fifth to sixth generation, corresponding to a dilution of C5b-7 complexes to 50-100 molecules/CFU. In the presence of 2 mM EDTA, further dilution of C5b-7 down to 8-30 complexes/CFU still caused 50% killing of daughter cells. Third, treatment of C5b-7 cells with purified CC8 and C9 results in the release of intracellular K+, which commences immediately after addition of C8/C9. This was shown in experiments where C5b-7 cells were packed to high density in saline, post-treated with C8 + C9, and K+ directly measured in the cell supernatants. Based on these results, we propose that C5b-9 pores deposited in the outer bacterial membrane periodically fuse with the inner membrane, the transmural pores thus generated permitting rapid K+ efflux, with cell death ensuing through the collapse of membrane potential. PMID:3530981

  1. [Correspondence from Julio Porto-Carrero to Arthur Ramos: the Brazilian Psychoanalytic Society and concern over the translation of psychoanalytic terms in the 1920s and 1930s].

    PubMed

    Castro, Rafael Dias de

    2015-12-01

    The article presents the correspondence that psychiatrist Julio Porto-Carrero sent to psychiatrist Arthur Ramos in 1932 to inform him about the activities of the Brazilian Psychoanalytic Society and about a concern over systematizing the translation of certain psychoanalytic concepts into Portuguese. This correspondence is used in conjunction with the analysis of other sources to suggest that psychiatrists and psychoanalysts in Rio de Janeiro were then endeavoring to make a place for psychoanalysis in the day's medical and scientific circles and encourage ever more specialists in Brazil to take an interest in Freud's theory. PMID:26625925

  2. Hidden symmetries and Lie algebra structures from geometric and supergravity Killing spinors

    NASA Astrophysics Data System (ADS)

    Açık, Özgür; Ertem, Ümit

    2016-08-01

    We consider geometric and supergravity Killing spinors and the spinor bilinears constructed out of them. The spinor bilinears of geometric Killing spinors correspond to the antisymmetric generalizations of Killing vector fields which are called Killing–Yano forms. They constitute a Lie superalgebra structure in constant curvature spacetimes. We show that the Dirac currents of geometric Killing spinors satisfy a Lie algebra structure up to a condition on 2-form spinor bilinears. We propose that the spinor bilinears of supergravity Killing spinors give way to different generalizations of Killing vector fields to higher degree forms. It is also shown that those supergravity Killing forms constitute a Lie algebra structure in six- and ten-dimensional cases. For five- and eleven-dimensional cases, the Lie algebra structure depends on an extra condition on supergravity Killing forms.

  3. Zika Kills Vital Nervous System Cells in Adult Mice, Study Finds

    MedlinePlus

    ... page: https://medlineplus.gov/news/fullstory_160505.html Zika Kills Vital Nervous System Cells in Adult Mice, ... 2016 THURSDAY, Aug. 18, 2016 (HealthDay News) -- The Zika virus kills neural stem cells in the brains ...

  4. Temporal Variability of Surface CO2 Emissions at the Horseshoe Lake Tree Kill, Mammoth Mountain, CA

    NASA Astrophysics Data System (ADS)

    Lewicki, J. L.; Rogie, J. D.; Hilley, G. E.; Fischer, M. L.; Tosha, T.; Aoyagi, R.; Benson, S. M.; Yamamoto, K.

    2006-12-01

    Mammoth Mountain is a dacitic volcano located on the southwestern rim of Long Valley caldera in eastern California. An eleven-month-long seismic swarm occurred beneath Mammoth in 1989 and was followed in 1990 by CO2 emissions around the flanks of the volcano, resulting in the formation of large areas of tree kill associated with high soil CO2 concentrations. Carbon dioxide emissions have persisted at Mammoth to the present day, allowing Mammoth to serve as a natural analogue for short-to-long-term CO2 leakage from geologic carbon storage sites. The Horseshoe Lake tree kill is the largest on the volcano and numerous investigations have been conducted here to quantify CO2 emission rates, determine spatial and temporal variability, and understand effects on the near-surface environment. In particular, continuous monitoring of soil CO2 fluxes (accumulation chamber method) and meteorological parameters at a point location was carried out along with repeat flux measurements along a grid in the tree-kill area in 1998-2000. Results showed large temporal variations in both point CO2 fluxes and total aerial CO2 emission rates driven primarily by fluctuations in wind and atmospheric pressure, rather than deep subsurface processes. We will build on previous studies of CO2 emissions at the Horseshoe Lake tree kill and present results of an investigation of CO2 emissions using the eddy covariance and accumulation chamber methods carried out in September-October, 2006. Spatially and temporally averaged net CO2 fluxes (eddy covariance method) will be used in conjunction with repeat point measurements of soil CO2 fluxes along a grid (accumulation chamber method) to quantify present-day CO2 emission, its temporal variability on half- hour to monthly time scales, and the physical controls on this variability. Implications of CO2 emissions at Mammoth Mountain for geologic carbon storage projects will be discussed. This work was supported in part by the Ernest Lawrence Berkeley

  5. Pulpability of beetle-killed spruce. Forest Service research paper

    SciTech Connect

    Scott, G.M.; Bormett, D.W.; Sutherland, N.R.; Abubakr, S.; Lowell, E.

    1996-08-01

    Infestation of the Dendroctonus rufipennis beetle has resulted in large stands of dead and dying timber on the Kenai Peninsula in Alaska. Tests were conducted to evaluate the value of beetle-killed spruce as pulpwood. The results showed that live and dead spruce wood can be pulped effectively. The two least deteriorated classes and the most deteriorated class of logs had similar characteristics when pulped; the remaining class had somewhat poorer pulpability.

  6. Invisible CO2 gas killing trees at Mammoth Mountain, California

    USGS Publications Warehouse

    Sorey, Michael L.; Farrar, Christopher D.; Evans, William C.; Hill, David P.; Bailey, Roy A.; Hendley, James W., II; Stauffer, Peter H.

    1996-01-01

    Since 1980, scientists have monitored geologic unrest in Long Valley Caldera and at adjacent Mammoth Mountain, California. After a persistent swarm of earthquakes beneath Mammoth Mountain in 1989, earth scientists discovered that large volumes of carbon dioxide (CO2) gas were seeping from beneath this volcano. This gas is killing trees on the mountain and also can be a danger to people. The USGS continues to study the CO2 emissions to help protect the public from this invisible potential hazard.

  7. Charged Particles Kill Pathogens and Round Up Dust

    NASA Technical Reports Server (NTRS)

    2015-01-01

    To keep plants fresh longer in space, Marshall Space Flight Center awarded funding to the University of Wisconsin-Madison to develop a titanium oxide-based device that reduced the amount of decay-inducing ethylene gas in the air. Electrolux (now Dallas-based Aerus Holdings) furthered the technology by developing an air purification product that kills pathogens both in the atmosphere and on surfaces.

  8. Morphological effect of oscillating magnetic nanoparticles in killing tumor cells

    NASA Astrophysics Data System (ADS)

    Cheng, Dengfeng; Li, Xiao; Zhang, Guoxin; Shi, Hongcheng

    2014-04-01

    Forced oscillation of spherical and rod-shaped iron oxide magnetic nanoparticles (MNPs) via low-power and low-frequency alternating magnetic field (AMF) was firstly used to kill cancer cells in vitro. After being loaded by human cervical cancer cells line (HeLa) and then exposed to a 35-kHz AMF, MNPs mechanically damaged cell membranes and cytoplasm, decreasing the cell viability. It was found that the concentration and morphology of the MNPs significantly influenced the cell-killing efficiency of oscillating MNPs. In this preliminary study, when HeLa cells were pre-incubated with 100 μg/mL rod-shaped MNPs (rMNP, length of 200 ± 50 nm and diameter of 50 to 120 nm) for 20 h, MTT assay proved that the cell viability decreased by 30.9% after being exposed to AMF for 2 h, while the cell viability decreased by 11.7% if spherical MNPs (sMNP, diameter of 200 ± 50 nm) were used for investigation. Furthermore, the morphological effect of MNPs on cell viability was confirmed by trypan blue assay: 39.5% rMNP-loaded cells and 15.1% sMNP-loaded cells were stained after being exposed to AMF for 2 h. It was also interesting to find that killing tumor cells at either higher (500 μg/mL) or lower (20 μg/mL) concentration of MNPs was less efficient than that achieved at 100 μg/mL concentration. In conclusion, the relatively asymmetric morphological rod-shaped MNPs can kill cancer cells more effectively than spherical MNPs when being exposed to AMF by virtue of their mechanical oscillations.

  9. [The vegetarian appeal and killing animals. An ethical challenge].

    PubMed

    Luy, J; Hildebrandt, G; von Mickwitz, G

    2001-01-01

    The demand for renunciation of killing animals has already been discussed by mankind since ancient times. Many arguments for and against this demand have accumulated in the meantime. The reproaches of the vegetarians repeatedly forced the ones who eat meat to justify their diet. Today most of these historical justifications however have to be rejected because of lacking plausibility. Many of the vegetarian arguments on the other hand must be rejected for similar reasons as well. Remaining as morally convincing is the demand for doing the killing absolutely painless and without frightening the animals, which was already formulated for example by Kant and Schopenhauer. Arguments which consider this way of killing as still immoral belong in a broad sense to the "anthropocentric" animal ethics. They do not belong to what is called in Germany "pathocentric" animal ethics, because an animal that is killed without being frightened or tortured, has not suffered, for it hasn't consciously realized anything like danger or harm. We do even argue that these animals are not harmed at all, because it seems senseless to talk about harm without negative conscious phenomena. To push ahead a ban on animal slaughter for moral reasons could be itself morally wrong because it would disturb indirectly many people's conscious well-being without being justified by protecting an animal's conscious well-being. It is however possible to derive from a general duty not to make animals suffer (pathocentric animal ethics) a duty to boycott food of animal origin if these animals had to suffer during their lives. PMID:11505802

  10. Defects in the oxidative killing of microorganisms by phagocytic leukocytes.

    PubMed

    Roos, D; Weening, R S

    One of the most important mechanisms of phagocytic killing of ingested microorganisms by leukocytes is the generation of toxic oxygen products. During phagocytosis, neutrophils, as well as monocytes and macrophages, display a strongly increased cell respiration. Quantitatively the most important product of this reaction is hydrogen peroxide. Superoxide is also generated in large amounts, probably as an intermediate in the formation of hydrogen peroxide. Indications exist that singlet oxygen and hydroxyl radicals are also formed in this process. Some of these oxygen products have microbicidal properties by themselves. The effect of hydrogen peroxide is greatly enhanced by the enzyme myeloperoxidase. Several dysfunctions of this sytem are known. In chronic granulomatous disease the enzyme system that produces superoxide is not operative. Thus, no superoxide or hydrogen peroxide is generated, leading to a severely decreased bacterial killing capacity. The exact molecular defects in the X-linked and the autosomal form are as yet undefined. Two variants are also known: lipochrome histiocytosis, with different clinical and histological manifestations, and a 'triggering defect' where only strongly opsonized particles trigger the respiratory burst. Myeloperoxidase deficiency leads to slightly decreased killing capacity, especially for yeasts. In glucose-6-phosphate dehydrogenase deficiency no oxygen radicals or hydrogen peroxide are produced because no equivalents for oxygen reduction can be generated in the hexose-monophosphate shunt. Deficiencies in the glutathione redox system also result in impaired phagocyte function, probably because the cells have to be protected against their own toxic oxygen products. PMID:225141

  11. Polyanhydride Nanoparticle Delivery Platform Dramatically Enhances Killing of Filarial Worms

    PubMed Central

    Binnebose, Andrea M.; Haughney, Shannon L.; Martin, Richard; Imerman, Paula M.; Narasimhan, Balaji; Bellaire, Bryan H.

    2015-01-01

    Filarial diseases represent a significant social and economic burden to over 120 million people worldwide and are caused by endoparasites that require the presence of symbiotic bacteria of the genus Wolbachia for fertility and viability of the host parasite. Targeting Wolbachia for elimination is a therapeutic approach that shows promise in the treatment of onchocerciasis and lymphatic filariasis. Here we demonstrate the use of a biodegradable polyanhydride nanoparticle-based platform for the co-delivery of the antibiotic doxycycline with the antiparasitic drug, ivermectin, to reduce microfilarial burden and rapidly kill adult worms. When doxycycline and ivermectin were co-delivered within polyanhydride nanoparticles, effective killing of adult female Brugia malayi filarial worms was achieved with approximately 4,000-fold reduction in the amount of drug used. Additionally the time to death of the macrofilaria was also significantly reduced (five-fold) when the anti-filarial drug cocktail was delivered within polyanhydride nanoparticles. We hypothesize that the mechanism behind this dramatically enhanced killing of the macrofilaria is the ability of the polyanhydride nanoparticles to behave as a Trojan horse and penetrate the cuticle, bypassing excretory pumps of B. malayi, and effectively deliver drug directly to both the worm and Wolbachia at high enough microenvironmental concentrations to cause death. These provocative findings may have significant consequences for the reduction in the amount of drug and the length of treatment required for filarial infections in terms of patient compliance and reduced cost of treatment. PMID:26496201

  12. Polyanhydride Nanoparticle Delivery Platform Dramatically Enhances Killing of Filarial Worms.

    PubMed

    Binnebose, Andrea M; Haughney, Shannon L; Martin, Richard; Imerman, Paula M; Narasimhan, Balaji; Bellaire, Bryan H

    2015-01-01

    Filarial diseases represent a significant social and economic burden to over 120 million people worldwide and are caused by endoparasites that require the presence of symbiotic bacteria of the genus Wolbachia for fertility and viability of the host parasite. Targeting Wolbachia for elimination is a therapeutic approach that shows promise in the treatment of onchocerciasis and lymphatic filariasis. Here we demonstrate the use of a biodegradable polyanhydride nanoparticle-based platform for the co-delivery of the antibiotic doxycycline with the antiparasitic drug, ivermectin, to reduce microfilarial burden and rapidly kill adult worms. When doxycycline and ivermectin were co-delivered within polyanhydride nanoparticles, effective killing of adult female Brugia malayi filarial worms was achieved with approximately 4,000-fold reduction in the amount of drug used. Additionally the time to death of the macrofilaria was also significantly reduced (five-fold) when the anti-filarial drug cocktail was delivered within polyanhydride nanoparticles. We hypothesize that the mechanism behind this dramatically enhanced killing of the macrofilaria is the ability of the polyanhydride nanoparticles to behave as a Trojan horse and penetrate the cuticle, bypassing excretory pumps of B. malayi, and effectively deliver drug directly to both the worm and Wolbachia at high enough microenvironmental concentrations to cause death. These provocative findings may have significant consequences for the reduction in the amount of drug and the length of treatment required for filarial infections in terms of patient compliance and reduced cost of treatment. PMID:26496201

  13. Effects of lead on the killing mechanisms of polymorphonuclear leukocytes

    SciTech Connect

    Silberstein, C.F.

    1984-01-01

    The effects of lead on the killing mechanisms of rat polymorphonuclear leukocytes (PMN) were investigated, using male Long-Evans rats exposed to 1% lead acetate in the drinking water for varying periods of time to achieve blood lead levels ranging from 20-200 ..mu..g/dl. Studies of PMN bacterial and fungal killing activity, chemotaxis and phagocytosis demonstrated that: 1) bactericidal activity of PMN from rats exposed to lead was not altered; 2) chemotactic activity remained within normal limits; 3) the phagocytic ability of the PMN also remained unaltered. In addition to these normal findings, one major abnormality was demonstrated: a significant decrease in the ability of PMN from rats exposed to lead to kill Candida albicans. This defect was not related to age or to length of exposure. It could not be produced by addition of lead to the test system in vitro. Further investigation revealed significant decreases in PMN glucose-6-phosphate dehydrogenase, catalase, and myeloperoxidase activities. These data support two possible mechanisms for the abnormal fungicidal activity of PMN from lead-exposed rats: decrease in ability to reduce oxygen to active metabolites, or reduction in myeloperoxidase activity due to diminshed synthesis of the heme moiety required for its function.

  14. Photoexcited quantum dots for killing multidrug-resistant bacteria

    NASA Astrophysics Data System (ADS)

    Courtney, Colleen M.; Goodman, Samuel M.; McDaniel, Jessica A.; Madinger, Nancy E.; Chatterjee, Anushree; Nagpal, Prashant

    2016-05-01

    Multidrug-resistant bacterial infections are an ever-growing threat because of the shrinking arsenal of efficacious antibiotics. Metal nanoparticles can induce cell death, yet the toxicity effect is typically nonspecific. Here, we show that photoexcited quantum dots (QDs) can kill a wide range of multidrug-resistant bacterial clinical isolates, including methicillin-resistant Staphylococcus aureus, carbapenem-resistant Escherichia coli, and extended-spectrum β-lactamase-producing Klebsiella pneumoniae and Salmonella typhimurium. The killing effect is independent of material and controlled by the redox potentials of the photogenerated charge carriers, which selectively alter the cellular redox state. We also show that the QDs can be tailored to kill 92% of bacterial cells in a monoculture, and in a co-culture of E. coli and HEK 293T cells, while leaving the mammalian cells intact, or to increase bacterial proliferation. Photoexcited QDs could be used in the study of the effect of redox states on living systems, and lead to clinical phototherapy for the treatment of infections.

  15. Antimicrobial metallic copper surfaces kill Staphylococcus haemolyticus via membrane damage

    PubMed Central

    Santo, Christophe Espírito; Quaranta, Davide; Grass, Gregor

    2012-01-01

    Recently, copper (Cu) in its metallic form has regained interest for its antimicrobial properties. Use of metallic Cu surfaces in worldwide hospital trials resulted in remarkable reductions in surface contaminations. Yet, our understanding of why microbes are killed upon contact to the metal is still limited and different modes of action have been proposed. This knowledge, however, is crucial for sustained use of such surfaces in hospitals and other hygiene-sensitive areas. Here, we report on the molecular mechanisms by which the Gram-positive Staphylococcus haemolyticus is inactivated by metallic Cu. Staphylococcus haemolyticus was killed within minutes on Cu but not on stainless steel demonstrating the antimicrobial efficacy of metallic Cu. Inductively coupled plasma mass spectroscopy (ICP-MS) analysis and in vivo staining with Coppersensor-1 indicated that cells accumulated large amounts of Cu ions from metallic Cu surfaces contributing to lethal damage. Mutation rates of Cu- or steel-exposed cells were similarly low. Instead, live/dead staining indicated cell membrane damage in Cu- but not steel-exposed cells. These findings support a model of the cellular targets of metallic Cu toxicity in bacteria, which suggests that metallic Cu is not genotoxic and does not kill via DNA damage. In contrast, membranes constitute the likely Achilles’ heel of Cu surface-exposed cells. PMID:22950011

  16. Default risk modeling with position-dependent killing

    NASA Astrophysics Data System (ADS)

    Katz, Yuri A.

    2013-04-01

    Diffusion in a linear potential in the presence of position-dependent killing is used to mimic a default process. Different assumptions regarding transport coefficients, initial conditions, and elasticity of the killing measure lead to diverse models of bankruptcy. One “stylized fact” is fundamental for our consideration: empirically default is a rather rare event, especially in the investment grade categories of credit ratings. Hence, the action of killing may be considered as a small parameter. In a number of special cases we derive closed-form expressions for the entire term structure of the cumulative probability of default, its hazard rate, and intensity. Comparison with historical data on aggregate global corporate defaults confirms the validity of the perturbation method for estimations of long-term probability of default for companies with high credit quality. On a single company level, we implement the derived formulas to estimate the one-year likelihood of default of Enron on a daily basis from August 2000 to August 2001, three months before its default, and compare the obtained results with forecasts of traditional structural models.

  17. Amphotericin primarily kills yeast by simply binding ergosterol

    PubMed Central

    Gray, Kaitlyn C.; Palacios, Daniel S.; Dailey, Ian; Endo, Matthew M.; Uno, Brice E.; Wilcock, Brandon C.; Burke, Martin D.

    2012-01-01

    Amphotericin B (AmB) is a prototypical small molecule natural product that can form ion channels in living eukaryotic cells and has remained refractory to microbial resistance despite extensive clinical utilization in the treatment of life-threatening fungal infections for more than half a century. It is now widely accepted that AmB kills yeast primarily via channel-mediated membrane permeabilization. Enabled by the iterative cross-coupling-based synthesis of a functional group deficient derivative of this natural product, we have discovered that channel formation is not required for potent fungicidal activity. Alternatively, AmB primarily kills yeast by simply binding ergosterol, a lipid that is vital for many aspects of yeast cell physiology. Membrane permeabilization via channel formation represents a second complementary mechanism that further increases drug potency and the rate of yeast killing. Collectively, these findings (i) reveal that the binding of a physiologically important microbial lipid is a powerful and clinically validated antimicrobial strategy that may be inherently refractory to resistance, (ii) illuminate a more straightforward path to an improved therapeutic index for this clinically vital but also highly toxic antifungal agent, and (iii) suggest that the capacity for AmB to form protein-like ion channels might be separable from its cytocidal effects. PMID:22308411

  18. Clarke, Arthur C (1917-)

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    Science fiction writer and space visionary, born in Minehead, Somerset, England. Worked during the second World War on radar ground controlled approach equipment, became president of the British Interplanetary Society. In 1945 he wrote a paper `Extra-terrestrial relays' which described the principle of satellites in geostationary orbits. The geostationary orbit at 42 000 kilometers has been named...

  19. Spacetimes with Killing tensors. [for Einstein-Maxwell fields with certain spinor indices

    NASA Technical Reports Server (NTRS)

    Hughston, L. P.; Sommers, P.

    1973-01-01

    The characteristics of the Killing equation and the Killing tensor are discussed. A conformal Killing tensor is of interest inasmuch as it gives rise to a quadratic first integral for null geodesic orbits. The Einstein-Maxwell equations are considered together with the Bianchi identity and the conformal Killing tensor. Two examples for the application of the considered relations are presented, giving attention to the charged Kerr solution and the charged C-metric.

  20. 77 FR 10960 - Security Zone, East River and Bronx Kill; Randalls and Wards Islands, NY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-24

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA87 Security Zone, East River and Bronx Kill; Randalls and... establishing a temporary security zone on the waters of the East River and Bronx Kill, in the vicinity of... is intended to restrict vessels from a portion of the East River and Bronx Kill when public...

  1. 9 CFR 113.200 - General requirements for killed virus vaccines.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false General requirements for killed virus..., DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.200 General requirements for killed virus vaccines. When prescribed...

  2. 9 CFR 113.200 - General requirements for killed virus vaccines.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false General requirements for killed virus..., DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.200 General requirements for killed virus vaccines. When prescribed...

  3. 9 CFR 113.200 - General requirements for killed virus vaccines.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false General requirements for killed virus..., DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.200 General requirements for killed virus vaccines. When prescribed...

  4. 9 CFR 113.200 - General requirements for killed virus vaccines.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false General requirements for killed virus..., DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.200 General requirements for killed virus vaccines. When prescribed...

  5. It’s Not Just Conflict That Motivates Killing of Orangutans

    PubMed Central

    Davis, Jacqueline T.; Mengersen, Kerrie; Abram, Nicola K.; Ancrenaz, Marc; Wells, Jessie A.; Meijaard, Erik

    2013-01-01

    We investigated why orangutans are being killed in Kalimantan, Indonesia, and the role of conflict in these killings. Based on an analysis of interview data from over 5,000 respondents in over 450 villages, we also assessed the socio-ecological factors associated with conflict and non-conflict killings. Most respondents never kill orangutans. Those who reported having personally killed an orangutan primarily did so for non-conflict reasons; for example, 56% of these respondents said that the reason they had killed an orangutan was to eat it. Of the conflict-related reasons for killing, the most common reasons orangutans were killed was fear of orangutans or in self-defence. A similar pattern was evident among reports of orangutan killing by other people in the villages. Regression analyses indicated that religion and the percentage of intact forest around villages were the strongest socio-ecological predictors of whether orangutans were killed for conflict or non-conflict related reasons. Our data indicate that between 44,170 and 66,570 orangutans were killed in Kalimantan within the respondents’ active hunting lifetimes: between 12,690 and 29,024 for conflict reasons (95%CI) and between 26,361 and 41,688 for non-conflict reasons (95% CI). These findings confirm that habitat protection alone will not ensure the survival of orangutans in Indonesian Borneo, and that effective reduction of orangutan killings is urgently needed. PMID:24130707

  6. Korn's inequality and Donati's theorem for the conformal Killing operator on pseudo-Euclidean space

    NASA Astrophysics Data System (ADS)

    Wang, Wei

    2008-09-01

    We prove the Korn's inequality for the conformal Killing operator on pseudo-Euclidean space , and an existence theorem for solutions to the non-homogeneous conformal Killing equation, which is a pseudo-Euclidean conformal generalization of Donati's theorem for Euclidean Killing operator.

  7. 9 CFR 113.202 - Canine Hepatitis and Canine Adenovirus Type 2 Vaccine, Killed Virus.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Canine Hepatitis and Canine Adenovirus...; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.202 Canine Hepatitis and Canine Adenovirus Type 2 Vaccine, Killed Virus. Canine Hepatitis and Canine Adenovirus Type 2 Vaccine, Killed...

  8. 9 CFR 113.202 - Canine Hepatitis and Canine Adenovirus Type 2 Vaccine, Killed Virus.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Canine Hepatitis and Canine Adenovirus...; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.202 Canine Hepatitis and Canine Adenovirus Type 2 Vaccine, Killed Virus. Canine Hepatitis and Canine Adenovirus Type 2 Vaccine, Killed...

  9. Designing Cancer-Killing Artificial Viruses to Improve Student Understanding of Microbiology

    PubMed Central

    Kuniyuki, Andy; Sharp, Gwen

    2011-01-01

    Our objective was to assess the effectiveness of a “learning by designing” group project used in a lower-division Microbiology course. Students used knowledge gained from the course to design an artificial virus that would kill cancer cells. The assignment required groups to integrate the individual course topics into a unified, complex understanding of the field of microbiology. Throughout the course, students and the instructor collaborated in creating a rubric to evaluate the groups’ final presentations. This paper reports the results of an assessment of the project by comparing the instructor’s and the students’ scores for the presentations. Students’ and the instructor’s scores were correlated; the Pearson coefficient of 0.52 was statistically significant. The results indicate that students gained sufficient knowledge to accurately evaluate proposed designs. Additionally, the overall course grade distribution improved compared to the semester before the project was introduced. Finally, in order to engage students in thinking about their own learning process, they completed a reflection assignment that required them to discuss the changes in their understanding of microbiology over the course of the semester. Our assessment indicates that a design project can serve as an effective and useful learning technique in undergraduate Microbiology courses, though modifications are suggested. PMID:23653757

  10. Project: "Project!"

    ERIC Educational Resources Information Center

    Grayson, Katherine

    2007-01-01

    In November 2006, the editors of "Campus Technology" launched their first-ever High-Resolution Projection Study, to find out if the latest in projector technology could really make a significant difference in teaching, learning, and educational innovation on US campuses. The author and her colleagues asked campus educators, technologists, and…

  11. Relief-well requirements to kill a high-rate gas blowout from a deepwater reservoir

    SciTech Connect

    Warriner, R.A. ); Cassity, T.G. )

    1988-12-01

    Relief-well requirements were investigated for a dynamic kill of a high-rate gas blowout from a deepwater reservoir to define any necessary special procedures or equipment. Results of the investigation show that a high injection rate and a special-design large-diameter injection riser are required to dynamically kill such a blowout with seawater. The injection riser is necessary to limit surface pump pressure during the high-rate kill operation. Procedures to complete the kill operation hydrostatically with heavy fluid following the dynamic kill are outlined.

  12. Nexavar/Stivarga and viagra interact to kill tumor cells.

    PubMed

    Tavallai, Mehrad; Hamed, Hossein A; Roberts, Jane L; Cruickshanks, Nichola; Chuckalovcak, John; Poklepovic, Andrew; Booth, Laurence; Dent, Paul

    2015-09-01

    We determined whether the multi-kinase inhibitor sorafenib or its derivative regorafenib interacted with phosphodiesterase 5 (PDE5) inhibitors such as Viagra (sildenafil) to kill tumor cells. PDE5 and PDGFRα/β were over-expressed in liver tumors compared to normal liver tissue. In multiple cell types in vitro sorafenib/regorafenib and PDE5 inhibitors interacted in a greater than additive fashion to cause tumor cell death, regardless of whether cells were grown in 10 or 100% human serum. Knock down of PDE5 or of PDGFRα/β recapitulated the effects of the individual drugs. The drug combination increased ROS/RNS levels that were causal in cell killing. Inhibition of CD95/FADD/caspase 8 signaling suppressed drug combination toxicity. Knock down of ULK-1, Beclin1, or ATG5 suppressed drug combination lethality. The drug combination inactivated ERK, AKT, p70 S6K, and mTOR and activated JNK. The drug combination also reduced mTOR protein expression. Activation of ERK or AKT was modestly protective whereas re-expression of an activated mTOR protein or inhibition of JNK signaling almost abolished drug combination toxicity. Sildenafil and sorafenib/regorafenib interacted in vivo to suppress xenograft tumor growth using liver and colon cancer cells. From multiplex assays on tumor tissue and plasma, we discovered that increased FGF levels and ERBB1 and AKT phosphorylation were biomarkers that were directly associated with lower levels of cell killing by 'rafenib + sildenafil. Our data are now being translated into the clinic for further determination as to whether this drug combination is a useful anti-tumor therapy for solid tumor patients. PMID:25704960

  13. New fish-killing alga in coastal Delaware produces neurotoxins.

    PubMed

    Bourdelais, Andrea J; Tomas, Carmelo R; Naar, Jerome; Kubanek, Julia; Baden, Daniel G

    2002-05-01

    Ten fish mortality events, involving primarily Atlantic menhaden, occurred from early July through September 2000 in several bays and creeks in Delaware, USA. Two events involved large mortalities estimated at 1-2.5 million fish in Bald Eagle Creek, Rehoboth Bay. Samples from Indian Inlet (Bethany Beach), open to the Atlantic, as well as from an enclosed area of massive fish kills at nearby Bald Eagle Creek and Torque Canal were collected and sent to our laboratory for analysis. Microscopic examination of samples from the fish kill site revealed the presence of a single-cell Raphidophyte alga Chattonella cf. verruculosa at a maximum density of 1.04 x 10(7) cells/L. Naturally occurring brevetoxins were also detected in the bloom samples. Besides the Chattonella species, no other known brevetoxin-producing phytoplankton were present. Chromatographic, immunochemical, and spectroscopic analyses confirmed the presence of brevetoxin PbTx-2, and PbTx-3 and -9 were confirmed by chromatographic and immunochemical analyses. This is the first confirmed report in the United States of brevetoxins associated with an indigenous bloom in temperate Atlantic estuarine waters and of C. cf. verruculosa as a resident toxic organism implicated in fish kills in this area. The bloom of Chattonella continued throughout September and eventually declined in October. By the end of October C. cf. verruculosa was no longer seen, nor was toxin measurable in the surface waters. The results affirm that to avoid deleterious impacts on human and ecosystem health, increased monitoring is needed for brevetoxins and organism(s) producing them, even in areas previously thought to be unaffected. PMID:12003749

  14. Mothers who kill: evolutionary underpinnings and infanticide law.

    PubMed

    Friedman, Susan Hatters; Cavney, James; Resnick, Phillip J

    2012-01-01

    Women who kill their children present a profound challenge to accepted notions of motherhood and the protection offered by mothers to their children. Historically, societies have varied in the sanctions applied to perpetrators of such acts, across both time and place. Where penalties were once severe and punitive for mothers, in modern times some two dozen nations now have infanticide acts that reduce the penalties for mothers who kill their infants. Embedded within these acts are key criteria that relate (a) only to women who are (b) suffering the hormonal or mood effects of pregnancy/lactation at the time of the offence which is (c) usually restricted to within the first year after delivery. Criticisms of infanticide legislation have largely centered on inherent gender bias, misconceptions about the hormonal basis of postpartum psychiatric disorders, and the nexus and contribution of these disorders to the offending in relation to issues of culpability and sentencing. Important differences between female perpetrators relative to the age of the child victim have also highlighted problems in the implementation of infanticide legislation. For example, women who commit neonaticide (murder during the first day of life) differ substantially from mentally ill mothers who kill older children. However, despite these shortcomings, many nations have in recent years chosen to retain their infanticide acts. This article reviews the central controversies of infanticide legislation in relation to current research and fundamental fairness. Using evolutionary psychology as a theoretical framework to organize this discussion, it is argued that infanticide legislation is at best unnecessary and at worst misapplied, in that it exculpates criminal intent and fails to serve those for whom an infanticide defense might otherwise have been intended. PMID:22961624

  15. Trichinella spiralis: killing of newborn larvae by lung cells.

    PubMed

    Falduto, Guido H; Vila, Cecilia C; Saracino, María P; Calcagno, Marcela A; Venturiello, Stella M

    2015-02-01

    The migratory stage of Trichinella spiralis, the newborn larva (NBL), travels along the pulmonary microvascular system on its way to the skeletal muscle cells. The present work studies the capability of lung cells to kill NBL. For this purpose, in vitro cytotoxicity assays were performed using NBL, lung cell suspensions from Wistar rats, rat anti-NBL surface sera, and fresh serum as complement source. The cytotoxic activity of lung cells from rats infected on day 6 p.i. was compared with that from noninfected rats. Two and 20 h-old NBL (NBL2 and NBL20) were used as they had shown to exhibit different surface antigens altering their biological activity. Sera antibodies were analyzed by indirect immunofluorescence assay, and cell populations used in each assay were characterized by histological staining. The role of IgE in the cytotoxic attack against NBL was analyzed using heated serum. The FcεRI expression on cell suspensions was examined by flow cytometry. Results showed that lung cells were capable of killing NBL by antibody-dependent cell-mediated cytotoxicity (ADCC). Lung cells from infected animals yielded the highest mortality percentages of NBL, with NBL20 being the most susceptible to such attack. IgE yielded a critical role in the cytotoxic attack. Regarding the analysis of cell suspensions, cells from infected rats showed an increase in the percentage of eosinophils, neutrophils, and the number of cells expressing the FcεRI receptor. We conclude that lung cells are capable of killing NBL in the presence of specific antibodies, supporting the idea that the lung is one of the sites where the NBL death occurs due to ADCC. PMID:25416332

  16. Well control equations modified for slim-hole kill operations

    SciTech Connect

    Prince, P.K. ); Cowell, E.E. )

    1993-09-27

    Conventional well control equations modified to account for high annular pressure losses can improve well control in slimhole drilling. Previous solutions to the slim-hole well kill problem depended on unpracticed dynamic techniques in which neither the position and volume of the influx nor the pressure applied to the well bore is precisely known. One of the major barriers to the introduction of slim-hole drilling technology to oil field operations was perceived to be the difficulty of maintaining safe standards of well control There are two basic problems with using conventional methods on slim holes: Because of the reduced kick tolerance in a well with a small annular capacity, the kick detection system must be able to detect a relatively small influx of approximately 1 bbl. Conventional well kill techniques, such as the wait-and-weight method, depend on the annular pressure losses being a small fraction of the total circulating system pressure loss. A small overbalance is thereby maintained without causing fluid losses in the open hole. This assumption of low friction losses in the annulus is often not valid in slim-hole wells. The forces occurring during a well kill operation were analyzed to develop the modified well control equations for slim holes. Several other well control situations unique to slim holes were considered: the effect of annular friction pressure losses that are greater than the shut-in casing pressure, the effects of these high pressures on maximum allowable anticipated surface pressure, and the behavior of surface circulating systems.

  17. Nexavar/Stivarga and Viagra Interact to Kill Tumor Cells

    PubMed Central

    TAVALLAI, MEHRAD; HAMED, HOSSEIN A.; ROBERTS, JANE L.; CRUICKSHANKS, NICHOLA; CHUCKALOVCAK, JOHN; POKLEPOVIC, ANDREW; BOOTH, LAURENCE; DENT, PAUL

    2016-01-01

    We determined whether the multi-kinase inhibitor sorafenib or its derivative regorafenib interacted with phosphodiesterase 5 (PDE5) inhibitors such as Viagra (sildenafil) to kill tumor cells. PDE5 and PDGFRα/β were over-expressed in liver tumors compared to normal liver tissue. In multiple cell types in vitro sorafenib/regorafenib and PDE5 inhibitors interacted in a greater than additive fashion to cause tumor cell death, regardless of whether cells were grown in 10 or 100% human serum. Knock down of PDE5 or of PDGFRα/β recapitulated the effects of the individual drugs. The drug combination increased ROS/RNS levels that were causal in cell killing. Inhibition of CD95/FADD/caspase 8 signaling suppressed drug combination toxicity. Knock down of ULK-1, Beclin1, or ATG5 suppressed drug combination lethality. The drug combination inactivated ERK, AKT, p70 S6K, and mTOR and activated JNK. The drug combination also reduced mTOR protein expression. Activation of ERK or AKT was modestly protective whereas re-expression of an activated mTOR protein or inhibition of JNK signaling almost abolished drug combination toxicity. Sildenafil and sorafenib/regorafenib interacted in vivo to suppress xenograft tumor growth using liver and colon cancer cells. From multiplex assays on tumor tissue and plasma, we discovered that increased FGF levels and ERBB1 and AKT phosphorylation were biomarkers that were directly associated with lower levels of cell killing by ‘rafenib + sildenafil. Our data are now being translated into the clinic for further determination as to whether this drug combination is a useful anti-tumor therapy for solid tumor patients. PMID:25704960

  18. Invisible CO2 gas killing trees at Mammoth Mountain, California

    USGS Publications Warehouse

    Sorey, Michael L.; Farrar, Christopher D.; Gerlach, Terrance M.; McGee, Kenneth A.; Evans, William C.; Colvard, Elizabeth M.; Hill, David P.; Bailey, Roy A.; Rogie, John D.; Hendley, James W., II; Stauffer, Peter H.

    2000-01-01

    Since 1980, scientists have monitored geologic unrest in Long Valley Caldera and at adjacent Mammoth Mountain, California. After a persistent swarm of earthquakes beneath Mammoth Mountain in 1989, geologists discovered that large volumes of carbon dioxide (CO2 ) gas were seeping from beneath this volcano. This gas is killing trees on the mountain and also can be a danger to people. The U.S. Geological Survey (USGS) continues to study the CO2 emissions to help protect the public from this invisible potential hazard.

  19. Mitochondria: An intriguing target for killing tumour-initiating cells.

    PubMed

    Yan, Bing; Dong, Lanfeng; Neuzil, Jiri

    2016-01-01

    Tumour-initiating cells (TICs) play a pivotal role in cancer initiation, metastasis and recurrence, as well as in resistance to therapy. Therefore, development of drugs targeting TICs has become a focus of contemporary research. Mitochondria have emerged as a promising target of anti-cancer therapies due to their specific role in cancer metabolism and modulation of apoptotic pathways. Mitochondria of TICs possess special characteristics, some of which can be utilised to design drugs specifically targeting these cells. In this paper, we will review recent research on TICs and their mitochondria, and introduce drugs that kill these cells by way of mitochondrial targeting. PMID:26702582

  20. Static spherically symmetric space-times with six Killing vectors

    SciTech Connect

    Qadir, A.; Ziad, M.

    1988-11-01

    It had been proved earlier that spherically symmetric, static space-times have ten, seven, six, or four independent Killing vectors (KV's), but there are no cases in between. The case of six KV's is investigated here. It is shown that the space-time corresponds to a hyperboloid cross a sphere, reminiscent of Kaluza--Klein theory, with a compactification from four down to two dimensions. In effect, there is a unique metric for this space-time corresponding to a uniform mass distribution over all space.

  1. Attachment of killed Mycoplasma gallisepticum cells and membranes to erythrocytes

    SciTech Connect

    Banai, M.; Kahane, I.; Feldner, J.; Razin, S.

    1981-11-01

    To correlate viability with attachment capacity, Mycoplasma gallisepticum cells harvested at different growth phases and treated by various agents were tested for their capacity to attach to human erythrocytes. The results show that viability per se is not essential for M. gallisepticum attachment to erythrocytes, as cells killed by ultraviolet irradiation and membranes isolated by lysing M. gallisepticum cells by various means retained attachment capacity. However, treatment of the mycoplasmas by protein-denaturing agents, such as heart, glutaraldehyde, or prolonged exposure to low pH, drastically affected or even abolished attachment, supporting the protein nature of the mycoplasma membrane components responsible for specific binding to the sialoglycoprotein receptors on the erythrocytes.

  2. Sabretoothed carnivores and the killing of large prey.

    PubMed

    Andersson, Ki; Norman, David; Werdelin, Lars

    2011-01-01

    Sabre-like canines clearly have the potential to inflict grievous wounds leading to massive blood loss and rapid death. Hypotheses concerning sabretooth killing modes include attack to soft parts such as the belly or throat, where biting deep is essential to generate strikes reaching major blood vessels. Sabretoothed carnivorans are widely interpreted as hunters of larger and more powerful prey than that of their present-day nonsabretoothed relatives. However, the precise functional advantage of the sabretooth bite, particularly in relation to prey size, is unknown. Here, we present a new point-to-point bite model and show that, for sabretooths, depth of the killing bite decreases dramatically with increasing prey size. The extended gape of sabretooths only results in considerable increase in bite depth when biting into prey with a radius of less than ∼10 cm. For sabretooths, this size-reversed functional advantage suggests predation on species within a similar size range to those attacked by present-day carnivorans, rather than "megaherbivores" as previously believed. The development of the sabretooth condition appears to represent a shift in function and killing behaviour, rather than one in predator-prey relations. Furthermore, our results demonstrate how sabretoothed carnivorans are likely to have evolved along a functionally continuous trajectory: beginning as an extension of a jaw-powered killing bite, as adopted by present-day pantherine cats, followed by neck-powered biting and thereafter shifting to neck-powered shear-biting. We anticipate this new insight to be a starting point for detailed study of the evolution of pathways that encompass extreme specialisation, for example, understanding how neck-powered biting shifts into shear-biting and its significance for predator-prey interactions. We also expect that our model for point-to-point biting and bite depth estimations will yield new insights into the behaviours of a broad range of extinct predators

  3. Analysis of murine cellular receptors for tumor-killing factor

    SciTech Connect

    Ohsawa, F.; Natori, S.

    1987-01-01

    Receptors for tumor-killing factor (TKF) on the surface of murine cells were analyzed using radioiodinated TKF. Not only sensitive cells but also insensitive cells were found to have specific receptors. Among the sensitive cells, no clear relation was observed between the number of receptors on the cell surface and sensitivity to TKF. Compounds affecting microfilaments (cytochalasin B and D) and microtubules (colchicine and Colcemid) significantly inhibited cytolysis of sensitive cells induced by receptor-bound TKF. It is concluded that internalization of receptor-bound TKF is a prerequisite for triggering cytolysis.

  4. Homicide by direct snake bite: a case of contract killing.

    PubMed

    Ambade, Vipul Namdeorao; Borkar, Jaydeo Laxman; Meshram, Satin Kalidas

    2012-01-01

    It has been estimated that five million snake bite cases occur worldwide every year, causing about 100,000 deaths. Snake bite is exclusively accidental in nature. Suicide by snake bite is very rare and homicidal snake bite is not reported. In the present case, a contract killer was hired, who used a poisonous snake to kill an elderly couple by way of direct snake bite. We believe this to be the first case reported where a snake was directly used for the murder of two victims through a contract killer. PMID:22399029

  5. (M-theory-)Killing spinors on symmetric spaces

    SciTech Connect

    Hustler, Noel; Lischewski, Andree

    2015-08-15

    We show how the theory of invariant principal bundle connections for reductive homogeneous spaces can be applied to determine the holonomy of generalised Killing spinor covariant derivatives of the form D = ∇ + Ω in a purely algebraic and algorithmic way, where Ω : TM → Λ{sup ∗}(TM) is a left-invariant homomorphism. Specialising this to the case of symmetric M-theory backgrounds (i.e., (M, g, F) with (M, g) an eleven-dimensional Lorentzian (locally) symmetric space and F an invariant closed 4-form), we derive several criteria for such a background to preserve some supersymmetry and consequently find all supersymmetric symmetric M-theory backgrounds.

  6. The Computerized MacArthur Story Stem Battery--a pilot study of a novel medium for assessing children's representations of relationships.

    PubMed

    Minnis, Helen; Millward, Reuben; Sinclair, Claire; Kennedy, Eilis; Greig, Anne; Towlson, Kate; Read, Warren; Hill, Jonathan

    2006-01-01

    Story stem measures allow the assessment of children's representations of relationship functioning, but are expensive and time-consuming to administer. We developed a computerized story stem measure which does not require specific training for administrators and which allows the child to produce their own animated, narrated story completion. This paper describes, firstly, the reliability of the Computerized MacArthur Story Stem Battery (CMSSB) and, secondly, a preliminary comparison of children in foster care and school controls on narrative coherence, intentionality and avoidance. The CMSSB showed good inter-rater reliability. A group of children in foster care showed significantly poorer coherence of narrative, less intentionality and greater avoidance on the CMSSB compared to a school comparison group. PMID:17266016

  7. Killing for the state: the darkest side of American nursing.

    PubMed

    Holmes, Dave; Federman, Cary

    2003-03-01

    The aim of this article is to bring to the attention of the international nursing community the discrepancy between a pervasive 'caring' nursing discourse and a most unethical nursing practice in the United States. In this article, we present a duality: the conflict in American prisons between nursing ethics and the killing machinery. The US penal system is a setting in which trained healthcare personnel practice the extermination of life. We look upon the sanitization of deathwork as an application of healthcare professionals' skills and knowledge and their appropriation by the state to serve its ends. A review of the states' death penalty statutes shows that healthcare workers are involved in the capital punishment process and shielded by American laws (and to a certain extent by professional boards through their inaction). We also argue that the law's language often masks that involvement; and explain how states further that duplicity behind legal formalisms. In considering the important role healthcare providers, namely nurses and physicians, play in administering death to the condemned, we assert that nurses and physicians are part of the states' penal machinery in America. Nurses and physicians (as carriers of scientific knowledge, and also as agents of care) are intrinsic to the American killing enterprise. Healthcare professionals who take part in execution protocols are state functionaries who approach the condemned body as angels of death: they constitute an extension of the state which exercises its sovereign power over captive prisoners. PMID:12622799

  8. Midgut microbiota and host immunocompetence underlie Bacillus thuringiensis killing mechanism.

    PubMed

    Caccia, Silvia; Di Lelio, Ilaria; La Storia, Antonietta; Marinelli, Adriana; Varricchio, Paola; Franzetti, Eleonora; Banyuls, Núria; Tettamanti, Gianluca; Casartelli, Morena; Giordana, Barbara; Ferré, Juan; Gigliotti, Silvia; Ercolini, Danilo; Pennacchio, Francesco

    2016-08-23

    Bacillus thuringiensis is a widely used bacterial entomopathogen producing insecticidal toxins, some of which are expressed in insect-resistant transgenic crops. Surprisingly, the killing mechanism of B. thuringiensis remains controversial. In particular, the importance of the septicemia induced by the host midgut microbiota is still debated as a result of the lack of experimental evidence obtained without drastic manipulation of the midgut and its content. Here this key issue is addressed by RNAi-mediated silencing of an immune gene in a lepidopteran host Spodoptera littoralis, leaving the midgut microbiota unaltered. The resulting cellular immunosuppression was characterized by a reduced nodulation response, which was associated with a significant enhancement of host larvae mortality triggered by B. thuringiensis and a Cry toxin. This was determined by an uncontrolled proliferation of midgut bacteria, after entering the body cavity through toxin-induced epithelial lesions. Consequently, the hemolymphatic microbiota dramatically changed upon treatment with Cry1Ca toxin, showing a remarkable predominance of Serratia and Clostridium species, which switched from asymptomatic gut symbionts to hemocoelic pathogens. These experimental results demonstrate the important contribution of host enteric flora in B. thuringiensis-killing activity and provide a sound foundation for developing new insect control strategies aimed at enhancing the impact of biocontrol agents by reducing the immunocompetence of the host. PMID:27506800

  9. Viscoelastic Muds---Top-Kill in Rapidly Flowing Wells

    NASA Astrophysics Data System (ADS)

    Katz, Jonathan

    2011-04-01

    The attempted ``top-kill'' of the blown out Macondo (Deepwater Horizon) oil well by pumping a dense drilling ``mud'', i.e., a slurry of dense minerals, from above failed. This failure may be attributed to a Kelvin-Helmholtz instability in the gravity driven counterflow between the descending ``mud'' and the rapidly upwelling crude oil. The instability produced turbulence that dispersed the denser fluid into small packets (if miscible with the oil) or droplets (if immiscible). Estimates from turbulence theory imply that the packets or droplets are so small (sub-mm) that their settling speed in the oil is less than the upwelling speed, with the consequence that the ``mud'' is spat out of the well, as observed, rather than descending to fill the bottom of the well bore and providing the hdyrodstatic head required to ``kill'' the well. The addition of a shear-thickening or viscoelastic polymer to the ``mud'' may suppress the turbulence and prevent its dispersal. Laboratory experiments with viscoelastic surrogate ``muds'' show complete turbulence suppression at the relevant speeds, with the viscoelastic fluid descending as a coherent slug. These experiments find several new phenomena. At high flow rates there is a viscoelastic analogue of the viscous buckling instability. At low flow rates suppression of the Plateau-Rayleigh instability combined with the dependence of viscous flow rate on diameter leads to the formation of globules on a looping filament. I thank LLNL, where the experimental work was done, for hospitality.

  10. Photoacoustically-guided photothermal killing of mosquitoes targeted by nanoparticles.

    PubMed

    Foster, Stephen R; Galanzha, Ekaterina I; Totten, Daniel C; Beneš, Helen; Shmookler Reis, Robert J; Zharov, Vladimir P

    2014-07-01

    In biomedical applications, nanoparticles have demonstrated the potential to eradicate abnormal cells in small localized pathological zones associated with cancer or infections. Here, we introduce a method for nanotechnology-based photothermal (PT) killing of whole organisms considered harmful to humans or the environment. We demonstrate that laser-induced thermal, and accompanying nano- and microbubble phenomena, can injure or kill C. elegans and mosquitoes fed carbon nanotubes, gold nanospheres, gold nanoshells, or magnetic nanoparticles at laser energies that are safe for humans. In addition, a photoacoustic (PA) effect was used to control nanoparticle delivery. Through the integration of this technique with molecular targeting, nanoparticle clustering, magnetic capturing and spectral sharpening of PA and PT plasmonic resonances, our laser-based PA-PT nano-theranostic platform can be applied to detection and the physical destruction of small organisms and carriers of pathogens, such as malaria vectors, spiders, bed bugs, fleas, ants, locusts, grasshoppers, phytophagous mites, or other arthropod pests, irrespective of their resistance to conventional treatments. PMID:23450780

  11. Effectiveness of live or killed plague vaccines in man

    PubMed Central

    Meyer, K. F.

    1970-01-01

    While the safety of the available live plague vaccine EV 76 (Paris) continues to be the subject of further study, the USP formol-killed, virulent Pasteurella pestis (Yersinia pestis) suspension capable of protecting 60% of non-human primates, particularly Hanuman langurs (Presbytis entellus), warrants further clinical tests and field trials. Inoculated in a dosage of 2×109 killed plague bacilli (1 ml), followed by a booster of 400 million organisms (0.2 ml) in 1-3 months, this vaccine stimulates the appearance of passive mouse-protection antibodies (below an index of 10) and passive haemagglutinins in 60%-65% of human subjects. Recent experiences in Viet-Nam demonstrate that personnel vaccinated with the USP vaccine, although frequently exposed, enjoy almost complete freedom from the disease. One of the 4 known and confirmed cases of bubonic plague in North Americans occurred in an unvaccinated individual. Among individuals inoculated with the USP vaccine, 2 confirmed cases of pneumonic plague and 1 case of asymptomatic pharyngeal plague have been recorded. The incidence of plague in the Republic of Viet-Nam during the past 3 years is estimated at 13 263 cases in a population in part vaccinated with a live plague which exhibited inadequate immunogenic efficacy in experimental tests. PMID:4988692

  12. Protecting the normal in order to better kill the cancer

    PubMed Central

    Liu, Bingya; Ezeogu, Lewis; Zellmer, Lucas; Yu, Baofa; Xu, Ningzhi; Joshua Liao, Dezhong

    2015-01-01

    Chemotherapy is the only option for oncologists when a cancer has widely spread to different body sites. However, almost all currently available chemotherapeutic drugs will eventually encounter resistance after their initial positive effect, mainly because cancer cells develop genetic alterations, collectively coined herein as mutations, to adapt to the therapy. Some patients may still respond to a second chemo drug, but few cases respond to a third one. Since it takes time for cancer cells to develop new mutations and then select those life-sustaining ones via clonal expansion, “run against time for mutations to emerge” should be a crucial principle for treatment of those currently incurable cancers. Since cancer cells constantly change to adapt to the therapy whereas normal cells are stable, it may be a better strategy to shift our focus from killing cancer cells per se to protecting normal cells from chemotherapeutic toxicity. This new strategy requires the development of new drugs that are nongenotoxic and can quickly, in just hours or days, kill cancer cells without leaving the still-alive cells with time to develop mutations, and that should have their toxicities confined to only one or few organs, so that specific protections can be developed and applied. PMID:26177855

  13. Univalent antibodies kill tumour cells in vitro and in vivo

    NASA Astrophysics Data System (ADS)

    Glennie, M. J.; Stevenson, G. T.

    1982-02-01

    Antibody molecules are bivalent, or less often multivalent, with each antibody site within a single molecule having the same specificity. Bivalency must enhance the tenacity of antibody attachment to cell surfaces, as dissociation will require simultaneous release at both sites. However, the bivalency of the antibody sometimes induces a target cell to undergo antigenic modulation1-3, thereby offering the cell a means of evading complement and the various effector cells recruited by the antibody. We have investigated the attack by univalent antibodies, which, despite removal of one antibody site, retain their Fc zones and hence their ability to recruit the killing agents, on neoplastic B lymphocytes of the guinea pig L2C line. Rabbit antibodies raised against surface immunoglobulin of these cells were partially digested with papain to yield the univalent Fab/c derivatives4,5. We report here that these derivatives showed enhanced cell killing both in vitro and in vivo, and that this enhancement appeared to derive from avoiding antigenic modulation.

  14. Oral Immunization of Mice with Killed Salmonella typhimurium Vaccine

    PubMed Central

    Waldman, Robert H.; Grunspan, Ruth; Ganguly, Rama

    1972-01-01

    A study was undertaken to assess the efficacy of oral, parenteral, and intraperitoneal immunization methods of administering killed Salmonella typhimurium vaccine to mice and to evaluate the effectiveness of single and multiple doses of the vaccine containing varied numbers of the killed bacteria. A further objective of this study was to evaluate the effect of adding substances to the vaccine to which have been ascribed “adjuvant” properties. The protection was estimated by isolation of bacteria from the spleen and feces after oral challenge of the mice with live S. typhimurium. The results showed that one or more doses of 1010 organisms given orally led to significant protection. This rate of protection increased proportionately with the number of doses up to 10 doses, which offered 100% protection. Streptomycin, when added to multiple doses of 109 or more organisms given orally, increased the degree of protection, but beryllium sulfate and pertussis vaccine did not. Although multiple doses afforded similar systemic protection by all three routes of immunization, oral immunization yielded significantly greater local protection than that observed after subcutaneous or intraperitoneal immunization. PMID:4564152

  15. Killing of gram-negative bacteria by lactoferrin and lysozyme.

    PubMed Central

    Ellison, R T; Giehl, T J

    1991-01-01

    Although lactoferrin has antimicrobial activity, its mechanism of action is not full defined. Recently we have shown that the protein alters the Gram-negative outer membrane. As this membrane protects Gram-negative cells from lysozyme, we have studied whether lactoferrin's membrane effect could enhance the antibacterial activity of lysozyme. We have found that while each protein alone is bacteriostatic, together they can be bactericidal for strains of V. cholerae, S. typhimurium, and E. coli. The bactericidal effect is dose dependent, blocked by iron saturation of lactoferrin, and inhibited by high calcium levels, although lactoferrin does not chelate calcium. Using differing media, the effect of lactoferrin and lysozyme can be partially or completely inhibited; the degree of inhibition correlating with media osmolarity. Transmission electron microscopy shows that E. coli cells exposed to lactoferrin and lysozyme at 40 mOsm become enlarged and hypodense, suggesting killing through osmotic damage. Dialysis chamber studies indicate that bacterial killing requires direct contact with lactoferrin, and work with purified LPS suggests that this relates to direct LPS-binding by the protein. As lactoferrin and lysozyme are present together in high levels in mucosal secretions and neutrophil granules, it is probable that their interaction contributes to host defense. Images PMID:1918365

  16. Physical process first law for bifurcate Killing horizons

    SciTech Connect

    Amsel, Aaron J.; Marolf, Donald; Virmani, Amitabh

    2008-01-15

    The physical process version of the first law for black holes states that the passage of energy and angular momentum through the horizon results in a change in area ({kappa}/8{pi}){delta}A={delta}E-{omega}{delta}J, so long as this passage is quasistationary. A similar physical process first law can be derived for any bifurcate Killing horizon in any spacetime dimension d{>=}3 using much the same argument. However, to make this law nontrivial, one must show that sufficiently quasistationary processes do in fact occur. In particular, one must show that processes exist for which the shear and expansion remain small, and in which no new generators are added to the horizon. Thorne, MacDonald, and Price considered related issues when an object falls across a d=4 black hole horizon. By generalizing their argument to arbitrary d{>=}3 and to any bifurcate Killing horizon, we derive a condition under which these effects are controlled and the first law applies. In particular, by providing a nontrivial first law for Rindler horizons, our work completes the parallel between the mechanics of such horizons and those of black holes for d{>=}3. We also comment on the situation for d=2.

  17. Porins facilitate nitric oxide-mediated killing of mycobacteria.

    PubMed

    Fabrino, Daniela Leite; Bleck, Christopher K E; Anes, Elsa; Hasilik, Andrej; Melo, Rossana C N; Niederweis, Michael; Griffiths, Gareth; Gutierrez, Maximiliano Gabriel

    2009-09-01

    Non-pathogenic mycobacteria such us Mycobacterium smegmatis reside in macrophages within phagosomes that fuse with late endocytic/lysosomal compartments. This sequential fusion process is required for the killing of non-pathogenic mycobacteria by macrophages. Porins are proteins that allow the influx of hydrophilic molecules across the mycobacterial outer membrane. Deletion of the porins MspA, MspC and MspD significantly increased survival of M. smegmatis in J774 macrophages. However, the mechanism underlying this observation is unknown. Internalization of wild-type M. smegmatis (SMR5) and the porin triple mutant (ML16) by macrophages was identical indicating that the viability of the porin mutant in vivo was enhanced. This was not due to effects on phagosome trafficking since fusion of phagosomes containing the mutant with late endocytic compartments was unaffected. Moreover, in ML16-infected macrophages, the generation of nitric oxide (NO) was similar to the wild type-infected cells. However, ML16 was significantly more resistant to the effects of NO in vitro compared to SMR5. Our data provide evidence that porins render mycobacteria vulnerable to killing by reactive nitrogen intermediates within phagosomes probably by facilitating uptake of NO across the mycobacterial outer membrane. PMID:19460455

  18. Identification of Pseudomonas aeruginosa Phenazines that Kill Caenorhabditis elegans

    PubMed Central

    Cezairliyan, Brent; Vinayavekhin, Nawaporn; Grenfell-Lee, Daniel; Yuen, Grace J.; Saghatelian, Alan; Ausubel, Frederick M.

    2013-01-01

    Pathogenic microbes employ a variety of methods to overcome host defenses, including the production and dispersal of molecules that are toxic to their hosts. Pseudomonas aeruginosa, a Gram-negative bacterium, is a pathogen of a diverse variety of hosts including mammals and the nematode Caenorhabditis elegans. In this study, we identify three small molecules in the phenazine class that are produced by P. aeruginosa strain PA14 that are toxic to C. elegans. We demonstrate that 1-hydroxyphenazine, phenazine-1-carboxylic acid, and pyocyanin are capable of killing nematodes in a matter of hours. 1-hydroxyphenazine is toxic over a wide pH range, whereas the toxicities of phenazine-1-carboxylic acid and pyocyanin are pH-dependent at non-overlapping pH ranges. We found that acidification of the growth medium by PA14 activates the toxicity of phenazine-1-carboxylic acid, which is the primary toxic agent towards C. elegans in our assay. Pyocyanin is not toxic under acidic conditions and 1-hydroxyphenazine is produced at concentrations too low to kill C. elegans. These results suggest a role for phenazine-1-carboxylic acid in mammalian pathogenesis because PA14 mutants deficient in phenazine production have been shown to be defective in pathogenesis in mice. More generally, these data demonstrate how diversity within a class of metabolites could affect bacterial toxicity in different environmental niches. PMID:23300454

  19. Antibiofouling Polyvinylidene Fluoride Membrane Modified by Quaternary Ammonium Compound: Direct Contact-Killing versus Induced Indirect Contact-Killing.

    PubMed

    Zhang, Xingran; Ma, Jinxing; Tang, Chuyang Y; Wang, Zhiwei; Ng, How Yong; Wu, Zhichao

    2016-05-17

    Widespread applications of membrane technology call for the development of antibiofouling membranes. For the traditional contact-killing strategy, the antibacterial action is restricted to the surface: the membrane loses its antibiofouling efficacy once its surface is completely covered with a fouling layer. However, in this study, polyvinylidene fluoride (PVDF) microfiltration membranes blended with quaternary ammonium compound (QAC) exhibited a surprisingly lasting antimicrobial activity in the vicinity of the membrane surface. The results indicated that QAC was capable of driving surface segregation with a high structural stability, and the QAC modified membrane shows clear antibacterial effects against both Gram-positive and Gram-negative bacteria. Covering the modified membrane surface by an abiotic alginate layer resulted in a loss of antibacterial efficiency by 86.2%. In contrast, the antibacterial efficiency was maintained after developing a biofilm of Staphylococcus aureus of 30 μm in thickness. The current study may suggest that bacteria affected by contact-killing might interact with other bacteria in the vicinity, resulting in retarded biofilm growth. The antibiofouling effect and associated mechanism of the QAC modified membrane were further validated in a membrane bioreactor during long-term operation. PMID:27104660

  20. Spacetime encodings. IV. The relationship between Weyl curvature and Killing tensors in stationary axisymmetric vacuum spacetimes

    SciTech Connect

    Brink, Jeandrew

    2010-01-15

    The problem of obtaining an explicit representation for the fourth invariant of geodesic motion (generalized Carter constant) of an arbitrary stationary axisymmetric vacuum spacetime generated from an Ernst potential is considered. The coupling between the nonlocal curvature content of the spacetime as encoded in the Weyl tensor, and the existence of a Killing tensor is explored and a constructive, algebraic test for a fourth-order Killing tensor suggested. The approach used exploits the variables defined for the Baecklund transformations to clarify the relationship between Weyl curvature, constants of geodesic motion, expressed as Killing tensors, and the solution-generation techniques. A new symmetric noncovariant formulation of the Killing equations is given. This formulation transforms the problem of looking for fourth-order Killing tensors in 4D into one of looking for four interlocking two-manifolds admitting fourth-order Killing tensors in 2D.