Science.gov

Sample records for aspectos recentes da

  1. Recent Improvements in the ATLAS PanDA Pilot

    NASA Astrophysics Data System (ADS)

    Nilsson, P.; Caballero Bejar, J.; Compostella, G.; Contreras, C.; De, K.; Dos Santos, T.; Maeno, T.; Potekhin, M.; Wenaus, T.

    2012-12-01

    The Production and Distributed Analysis system (PanDA) in the ATLAS experiment uses pilots to execute submitted jobs on the worker nodes. The pilots are designed to deal with different runtime conditions and failure scenarios, and support many storage systems. This talk will give a brief overview of the PanDA pilot system and will present major features and recent improvements including CernVM File System integration, the job retry mechanism, advanced job monitoring including JEM technology, and validation of new pilot code using the HammerCloud stress-testing system. PanDA is used for all ATLAS distributed production and is the primary system for distributed analysis. It is currently used at over 130 sites worldwide. We analyze the performance of the pilot system in processing LHC data on the OSG, EGI and Nordugrid infrastructures used by ATLAS, and describe plans for its further evolution.

  2. In vivo (R)-[(11)C]PK11195 PET imaging of 18kDa translocator protein in recent onset psychosis.

    PubMed

    van der Doef, Thalia F; de Witte, Lot D; Sutterland, Arjen L; Jobse, Ellen; Yaqub, Maqsood; Boellaard, Ronald; de Haan, Lieuwe; Eriksson, Jonas; Lammertsma, Adriaan A; Kahn, René S; van Berckel, Bart N M

    2016-01-01

    Evidence is accumulating that immune dysfunction is involved in the pathophysiology of schizophrenia. It has been hypothesized that microglia activation is present in patients with schizophrenia. Various in vivo and post-mortem studies have investigated this hypothesis, but as yet with inconclusive results. Microglia activation is associated with elevations in 18 kDa translocator protein (TSPO) levels, which can be measured with the positron emission tomography (PET) tracer (R)-[(11)C]PK11195. The purpose of the present study was to investigate microglia activation in psychosis in vivo at an early stage of the disease. (R)-[(11)C]PK11195 binding potential (BPND) was measured in 19 patients with recent onset psychosis and 17 age and gender-matched healthy controls. Total gray matter, as well as five gray matter regions of interest (frontal cortex, temporal cortex, parietal cortex, striatum, and thalamus) were defined a priori. PET data were analysed using a reference tissue approach and a supervised cluster analysis algorithm to identify the reference region. No significant difference in (R)-[(11)C]PK11195 BPND between patients and controls was found in total gray matter, nor one of the regions of interest. These findings suggest that microglia activation is not present in recent onset psychosis or that it is a subtle phenomenon that could not be detected using the design of the present study. PMID:27602389

  3. In vivo (R)-[11C]PK11195 PET imaging of 18kDa translocator protein in recent onset psychosis

    PubMed Central

    van der Doef, Thalia F; de Witte, Lot D; Sutterland, Arjen L; Jobse, Ellen; Yaqub, Maqsood; Boellaard, Ronald; de Haan, Lieuwe; Eriksson, Jonas; Lammertsma, Adriaan A; Kahn, René S; van Berckel, Bart N M

    2016-01-01

    Evidence is accumulating that immune dysfunction is involved in the pathophysiology of schizophrenia. It has been hypothesized that microglia activation is present in patients with schizophrenia. Various in vivo and post-mortem studies have investigated this hypothesis, but as yet with inconclusive results. Microglia activation is associated with elevations in 18 kDa translocator protein (TSPO) levels, which can be measured with the positron emission tomography (PET) tracer (R)-[11C]PK11195. The purpose of the present study was to investigate microglia activation in psychosis in vivo at an early stage of the disease. (R)-[11C]PK11195 binding potential (BPND) was measured in 19 patients with recent onset psychosis and 17 age and gender-matched healthy controls. Total gray matter, as well as five gray matter regions of interest (frontal cortex, temporal cortex, parietal cortex, striatum, and thalamus) were defined a priori. PET data were analysed using a reference tissue approach and a supervised cluster analysis algorithm to identify the reference region. No significant difference in (R)-[11C]PK11195 BPND between patients and controls was found in total gray matter, nor one of the regions of interest. These findings suggest that microglia activation is not present in recent onset psychosis or that it is a subtle phenomenon that could not be detected using the design of the present study. PMID:27602389

  4. Somatodendritic dopamine release: recent mechanistic insights.

    PubMed

    Rice, Margaret E; Patel, Jyoti C

    2015-07-01

    Dopamine (DA) is a key transmitter in motor, reward and cogitative pathways, with DA dysfunction implicated in disorders including Parkinson's disease and addiction. Located in midbrain, DA neurons of the substantia nigra pars compacta project via the medial forebrain bundle to the dorsal striatum (caudate putamen), and DA neurons in the adjacent ventral tegmental area project to the ventral striatum (nucleus accumbens) and prefrontal cortex. In addition to classical vesicular release from axons, midbrain DA neurons exhibit DA release from their cell bodies and dendrites. Somatodendritic DA release leads to activation of D2 DA autoreceptors on DA neurons that inhibit their firing via G-protein-coupled inwardly rectifying K(+) channels. This helps determine patterns of DA signalling at distant axonal release sites. Somatodendritically released DA also acts via volume transmission to extrasynaptic receptors that modulate local transmitter release and neuronal activity in the midbrain. Thus, somatodendritic release is a pivotal intrinsic feature of DA neurons that must be well defined in order to fully understand the physiology and pathophysiology of DA pathways. Here, we review recent mechanistic aspects of somatodendritic DA release, with particular emphasis on the Ca(2+) dependence of release and the potential role of exocytotic proteins. PMID:26009764

  5. The major histocompatibility complex genes impact pain response in DA and DA.1U rats.

    PubMed

    Guo, Yuan; Yao, Fan-Rong; Cao, Dong-Yuan; Li, Li; Wang, Hui-Sheng; Xie, Wen; Zhao, Yan

    2015-08-01

    Our recent studies have shown that the difference in basal pain sensitivity to mechanical and thermal stimulation between Dark-Agouti (DA) rats and a novel congenic DA.1U rats is major histocompatibility complex (MHC) genes dependent. In the present study, we further used DA and DA.1U rats to investigate the role of MHC genes in formalin-induced pain model by behavioral, electrophysiological and immunohistochemical methods. Behavioral results showed biphasic nociceptive behaviors increased significantly following the intraplantar injection of formalin in the hindpaw of DA and DA.1U rats. The main nociceptive behaviors were lifting and licking, especially in DA rats (P<0.001 and P<0.01). The composite pain scores (CPS) in DA rats were significantly higher than those in DA.1U rats in both phases of the formalin test (P<0.01). Electrophysiological results also showed the biphasic increase in discharge rates of C and Aδ fibers of L5 dorsal root in the two strains, and the net change of the discharge rate of DA rats was significantly higher than that of DA.1U rats (P<0.05). The mechanical thresholds decreased after formalin injection in both strains (P<0.01), and the net change in the mechanical threshold in DA was greater than that in DA.1U rats (P<0.05). The expression of RT1-B, representation of MHC class II molecule, in laminae I-II of L4/5 spinal cord in DA rats was significantly higher than that in DA.1U rats in the respective experimental group (P<0.05). These results suggested that both DA and DA.1U rats exhibited nociceptive responses in formalin-induced pain model and DA rats were more sensitive to noxious chemical stimulus than DA.1U rats, indicating that MHC genes might contribute to the difference in pain sensitivity. PMID:25861730

  6. The local effect of octreotide on mechanical pain sensitivity is more sensitive in DA rats than DA.1U rats.

    PubMed

    Yao, Fan-Rong; Wang, Hui-Sheng; Guo, Yuan; Zhao, Yan

    2016-02-01

    A recent study by the authors indicated that major histocompatibility complex (MHC) genes are associated with the differences in basal pain sensitivity and in formalin model between Dark-Agouti (DA) and novel congenic DA.1U rats, which have the same genetic background as DA rats except for the u alleles of MHC. The objective of the present study is to investigate whether there is a difference in the pristane-induced arthritis (PIA) model and local analgesic effect of octreotide (OCT) between DA and DA.1U rats. The hindpaw mechanical withdrawal threshold (MWT) and heat withdrawal latency (HWL) were observed. The C unit firings of the tibial nerve evoked by non-noxious and noxious toe movements were recorded by electrophysiological methods in normal and PIA models in DA and DA.1U rats before and after local OCT administration. The expression of somatostatin receptor 2A (SSTR2A) was observed by immunohistochemistry. The results demonstrate that DA rats have a higher mechanical sensitivity than DA.1U rats after PIA. Local OCT administration significantly elevated MWT in DA rats under normal and PIA sate, but not in DA.1U rats. The electrophysiological experiments showed OCT significantly attenuated the firings of C units evoked by non-noxious and noxious stimulation in DA rats more than those in DA.1U rats both in normal and PIA states. In addition, the expression of SSTR2A in the dorsal horn of the spinal cord was significantly higher in DA than in DA.1U rats. All of the findings suggest a higher local analgesic effect of OCT in DA rats than DA.1U rats, which might be associated with the MHC genes. PMID:26606866

  7. Recent Progress in Dehydro(genative) Diels-Alder Reaction.

    PubMed

    Li, Wenbo; Zhou, Liejin; Zhang, Junliang

    2016-01-26

    In recent years, remarkable progress has been made in dehydro or dehydrogenative Diels-Alder (D-A) reactions. This Minireview gives an overview of the major two strategies for dehydro(genative) Diels-Alder reactions, which differ in dehydrogenation and D-A cyclization sequence. Reactions in which D-A cycloaddition is followed by dehydrogenation are useful methods for the synthesis of various aromatic compounds, whereas advancements in dehydro genative procedures with oxidants or catalysts prior to D-A cycloaddition offer yet further new routes to functionalized cycloadducts. Recent leading findings are highlighted and the current state of the art, scope, and limitations of these processes are discussed in this Minireview. PMID:26786814

  8. Educating Recent Immigrants.

    ERIC Educational Resources Information Center

    IDRA Newsletter, 1994

    1994-01-01

    This newsletter contains six articles all related to the theme of education for recent legal and illegal immigrants. In "Golden Lord with Us from the Main Forest: Some Thoughts on the Education of Recent Immigrants," Aurelio M. Montemayor reflects on his experiences growing up in a bilingual, bicultural extended family of Mexican-American…

  9. Recent developments in radiosensitization.

    PubMed

    Linam, Justin; Yang, Li-Xi

    2015-05-01

    Radiation therapy is essential for local tumor control for many types of cancer histologies. Technological advancements in recent years have allowed for precise irradiation of target tissues while minimizing the dose to non-target tissues. To enhance radiation damage to cancer cells and further limit the radiation effects on normal tissue, researchers have explored compounds that specifically target cancer cells and make them more sensitive to ionizing radiation. Recent radiosensitization research has focused on promising compounds that alter hypoxia, inhibit topoisomerases, interfere with microtubules, and activate caspases, among other mechanisms. Many such compounds have shown impressive results in pre-clinical trials against a variety of cell types, but their safety, efficacy and practicability in clinical trials remains to be demonstrated. This review seeks to provide an overview of recent research in radiosensitization, detailing some of the more successful compounds, and illustrating avenues for future research. PMID:25964520

  10. Observational astrochemistry: recent results.

    PubMed

    Irvine, W M

    1989-01-01

    More than 80 molecular species have now been observed by astronomers in the dense interstellar clouds where stars and planets form or in the envelopes expelled by evolved stars. Elemental constituents of these compounds include all of the "biogenic" elements, hydrogen, carbon, nitrogen, oxygen, sulfur, and (most recently) phosphorus. In addition, silicon is found in several molecules, and a series of metal halides have recently been detected in the outflowing envelope of a nearby carbon star. Additions to the list of known interstellar molecules since the last COSPAR meeting are discussed individually. Recent measurements of the hydrogen isotopic fractionation for the cyclic molecule C3H2 are described; values up to 10,000 times the cosmic deuterium-to-hydrogen ratio are found. Knowledge of the chemical reservoirs for the major volatile elements and a comparison between observed molecular abundances and theoretical models are both discussed. PMID:11537359

  11. Recent Emulsion Technologies

    SciTech Connect

    Ariga, A.

    2011-10-06

    Emulsion technologies are very much developed in the last decade and still developing in both the emulsion gel and the data taking. Emulsion detectors are suitable for the neutrino experiments because they can distinguish all 3 flavors of neutrino. The OPERA experiment, a recent pillar in the emulsion experiments aiming at the first observation of the neutrino oscillation in CNGS beam in appearance mode, is running, showing the good capability to separate 3 flavor neutrino interactions. In this poster, the recent developments and prospects of the emulsions for the next generation experiments are reported.

  12. Nuevas Adquisiciones (Recent Acquisitions).

    ERIC Educational Resources Information Center

    Informacion Bibliografica Educativa, 1972

    1972-01-01

    This bibliography of educational materials lists approximately 100 publications recently acquired by the Colombian National Center for Documentation and Educational Information. The entries are listed according to subject matter; topics range from general educational theory to more specific subject topics. (VM)

  13. Recent developments in isotachophoresis

    NASA Technical Reports Server (NTRS)

    Thormann, Wolfgang; Mosher, Richard A.

    1986-01-01

    Recent advances in the field of isotachophoresis are discussed. These comprise (1) the utilization of digital simulation techniques for computer modeling of isotachophoretic systems of weak electrolytes, (2) the impacts of the models based on migration only, (3) the trend towards automated analytical instruments, and (4) the development of truly industrial-scale isotachophoresis amenable for downstream processing in biotechnology.

  14. Impedance cardiography: recent advancements.

    PubMed

    Cybulski, Gerard; Strasz, Anna; Niewiadomski, Wiktor; Gąsiorowska, Anna

    2012-01-01

    The aim of this paper is the presentation of recent advancements in impedance cardiography regarding methodical approach, applied equipment and clinical or research implementations. The review is limited to the papers which were published over last 17 months (dated 2011 and 2012) in well recognised scientific journals. PMID:23042327

  15. Recent results from CDF

    SciTech Connect

    R. Harr

    2004-01-26

    The authors report on the recent heavy-quark results from CDF in Run IIa. They focus on a selection of mature analyses that demonstrate the capabilities of the experiment to extract interesting physics from the data. A few of the results presented have already been submitted for publication and papers are being prepared for most of the others.

  16. Recent Developments in Dystonia

    PubMed Central

    Jinnah, H. A.; Teller, Jan K.; Galpern, Wendy R.

    2015-01-01

    Purpose of review The dystonias are a family of related disorders with many different clinical manifestations and causes. This review summarizes recent developments regarding these disorders, focusing mainly on advances with direct clinical relevance from the past two years. Recent findings The dystonias are generally defined by their clinical characteristics, rather than by their underlying genetic or neuropathological defects. The many varied clinical manifestations and causes contribute to the fact that they are one of the most poorly recognized of all movement disorders. A series of recent publications has addressed these issues offering a revised definition and more logical means for classifying the many subtypes. Our understanding of the genetic and neurobiological mechanisms responsible for different types of dystonias also has grown rapidly, creating new opportunities and challenges for diagnosis and identifying increasing numbers of rare subtypes for which specific treatments are available. Summary Recent advances in describing the clinical phenotypes and determining associated genotypes have pointed to the need for new strategies for diagnosis, classification and treatment of the dystonias. PMID:26110799

  17. Recent Tax Law Changes.

    ERIC Educational Resources Information Center

    Lukaszewski, Thomas

    1998-01-01

    Describes provisions of the Taxpayer Relief Act of 1997 as they influence business and personal taxes. Also explains a recent ruling, the IRS Revenue Procedure 96-31, which will benefit businesses which did not claim all the depreciation expenses they were entitled to over the years. (KB)

  18. Recent CDF results

    SciTech Connect

    Gomez, Gervasio; /Cantabria Inst. of Phys.

    2007-11-01

    As of November of 2007, the CDF detector has recorded approximately 2.7 fb{sup -1} of data. This contribution describes some of the most recent and most relevant results from the CDF collaboration in all areas of its wide physics program, as well as some insights into the Tevatron reach for Higgs searches within the next few years.

  19. Recent Progress in Picasso

    NASA Astrophysics Data System (ADS)

    Kumaratunga, Sujeewa

    2010-04-01

    PICASSO is a dark matter experiment based at SNOLAB. Sudbury (Ontario). It searches for spin dependent interactions of Weakly Interacting Massive Particles (WIMP) on 19F and uses superheated liquid C4F10 as its active detector component. PICASSO recently discovered that its signals contain information about the very nature of the primary event and therefore can be used to discriminate efficiently between WIMP signals, alpha particles and non-particle induced background sources. This paper will discuss this separation technique and present the current best limits on the WIMP-proton cross section in the spin dependent sector. With only two of the 32 detectors analyzed, a limit on the WIMP-proton cross section of σp = 0.16 pb (90% C.L.) has been obtained, restricting recent interpretations of the DAMA/LIBRA annual modulations.

  20. Recent EPA reports available

    SciTech Connect

    1993-11-01

    The EPA reports discussed below have recently been made available through the National Technical Information Service (NTIS) or EPA`s Office Research and Development (ORD). Studies were conducted recently to determine the suitability of incineration as a treatment technology for contaminated soils and sludges from three separate Superfund sites. All of the testing was performed at EPA`s incineration research facility in Jefferson, Arkansas. The test system consists of a rotary kiln incinerator, fired afterburner, wet flue gas scrubber (a venturi section in series with a packed column), and various other air pollution control equipment. EPA`s project summaries of the three reports, including results from the pilot-scale incineration tests, are summarized below. 1 fig., 2 tabs.

  1. Recent advances in dermoscopy

    PubMed Central

    Russo, Teresa; Piccolo, Vincenzo; Lallas, Aimilios; Argenziano, Giuseppe

    2016-01-01

    The use of dermoscopy has offered a new morphological dimension of skin lesions and has provided an effective diagnostic tool to differentiate melanoma from other benign or malignant skin tumors but also to support the clinical diagnosis in general dermatology. The aim of this article is to provide an overview of the most recent and important advances in the rising world of dermoscopy. PMID:26949523

  2. Recent applications of SUPERFISH

    NASA Astrophysics Data System (ADS)

    Gluckstern, R. L.; Neri, F.

    1988-12-01

    The program, SUPERFISH, obtains the frequencies and fields for azimuthally symmetric TM or TE modes in azimuthally symmetric cavities. The r-z plane is covered by a triangular mesh and the resulting difference equations for the field component Hφ(TM) or Eφ(TE) at the vertices of the mesh solved by direct matrix inversion. In the present paper, we describe a number of recent modifications of SUPERFISH. (AIP)

  3. Recent results from MAMI

    SciTech Connect

    Arends, Hans-Juergen

    2011-10-24

    The Mainz Microtron MAMI is an ideal facility to study the hadron structure with the electromagnetic probe. With the new accelerator stage (HDSM), which went into operation in 2007, high-intensity polarized electron and photon beams with energies up to 1.6 GeV are delivered to the experiments. Polarized targets and recoil polarimeters in combination with dedicated detectors are available for precision experiments in hadron physics. In this article, an overview over selected recent results is given.

  4. Recent MCNP developments

    SciTech Connect

    Hendricks, J.S.; Briesmeister, J.F.

    1991-01-01

    MCNP is a widely used and actively developed Monte Carlo radiation transport code. Many important features have recently been added and more are under development. Benchmark studies not only indicate that MCNP is accurate but also that modern computer codes can give answers basically as accurate as the physics data that goes in them. Even deep penetration problems can be correct to within a factor of two after 10 to 25 mean free paths of penetration. And finally, Monte Carlo calculations, once thought to be too expensive to run routinely, can now be run effectively on desktop computers which compete with the supercomputers of yesteryear. 21 refs., 3 tabs.

  5. Three recent TDHF calculations

    SciTech Connect

    Weiss, M.S.

    1981-05-01

    Three applications of TDHF are discussed. First, vibrational spectra of a post grazing collision /sup 40/Ca nucleus is examined and found to contain many high energy components, qualitatively consistent with recent Orsay experiments. Second, the fusion cross section in energy and angular momentum are calculated for /sup 16/O + /sup 24/Mg to exhibit the parameters of the low l window for this system. A sensitivity of the fusion cross section to the effective two body potential is discussed. Last, a preliminary analysis of /sup 86/Kr + /sup 139/La at E/sub lab/ = 505 MeV calculated in the frozen approximation is displayed, compared to experiment and discussed.

  6. Recent developments: Industry briefs

    SciTech Connect

    1992-04-01

    This article is the `Industry Briefs` portion of Nuexco`s April 1992 `Recent Developments` section. Items covered in this article include: (1) France`s SILVA enrichment process, (2) 1993 US enrichment prices, (3) relicensing plans for Monticello, (4) a reactor incident at Sosnovy Bor 3, (5) Canadian agreements on Uranium mining, (6) China`s ascession to the Nuclear Non-proliferation Treaty, (7) settlement of the lawsuit between Westinghouse and the Philipines, (8) political reforms on South Africa, and (9) establishment of an international agreement on dual-use export control policy.

  7. Recent BABAR Results

    SciTech Connect

    Eigen, Gerald

    2015-04-29

    We present herein the most recent BABAR results on direct CP asymmetry measurements in B → Xsγ, on partial branching fraction and CP asymmetry measurements in B → Xs+-, on a search for B → π/ηℓ+- decays, on a search for lepton number violation in B+ → X-+ℓ'+ modes and a study of B0 →ωω and B0 → ωφ decays.

  8. Recent activity in Turkey.

    PubMed

    1987-01-01

    The role of Pathfinder grants to recent family planning projects led by business and labor in Turkey is described. Pathfinder funded a major portion of the Turkish Family Planning and Health Foundation, a grant agency set up to complement government programs. One current project is a survey of family planning needs of squatter communities. The Foundation's founder established a factory-based family planning clinic, aided by Pathfinder, now self-supporting. The Turkish TURK-IS Labor Federation has supported several other worksite clinics, and has placed family planning among its top priorities. Pathfinder supported development of their population policy statement. Turkey has only recently passed progressive family planning legislation and permitted significant private sector activities. The population of 52 million is growing at 2.8%. Unemployment is high; per capita income is $1160. The government's goals are to reduce fertility from 4.3 to 2.5 children per woman and increase contraceptive prevalence from 20% to 60% by the year 2000. PMID:12179678

  9. Recent photonic detectors

    NASA Astrophysics Data System (ADS)

    Kume, Hidehiro; Shinoda, Yuji; Kamiya, Akifumi

    1997-05-01

    Recent improvements in analytical cytology instrumentation require the ultimate in performance from photosensors. Increases in sensitivity, extension of the spectral sensitivity range into the red, improvement of the response time and linear/area sensing are needed. This paper will introduce various photosensors recently developed by Hamamatsu. They will be sorted into groups based on performance or functional criteria as follows: (1) Photosensors: 1.1 Spectral response; We will present the variations in photoemissive materials for photomultiplier tubes (PMT) and solid state devices (SSD). 1.2 High speed; A list of high speed photosensors will be presented. In addition, we will introduce a compact module for phase modulation which is suitable for fluorescence analysis at a fast time range. 1.3 Gating; We will introduce a fast PMT gating module suitable for fluorescence measurement. The operating principle and characteristics are discussed. (2) Image sensors: a newly developed image sensor for spectroscopy will be introduced. They are Si linear image sensors for spectroscopy, InGaAs C-MOS linear image sensors for spectroscopy and full frame transfer (FFT) CCD's for low light imaging. We will discuss the outline and the characteristics of these sensors.

  10. Recent patents on flavonoids.

    PubMed

    Mamta, Gokhale; Bansal, Y K; Sandhu, S S

    2013-12-01

    Flavonoids are substances which are widely distributed in the plant kingdom. They occur in considerable quantities in common food products, spices and beverages. Interest of researchers has been greatly enhanced towards therapeutic potential of flavonoids in last some years. This review summarizes important patents pertaining to recent biotechnological techniques applied for the production, analysis of biosynthetic pathways, effects and applications of different flavonoids. For systematic studies investigations which have been published in the form of patents, are classified in different sectors like biosynthesis, medical application, antimicrobial activity, alteration of flower color, industrial application, cosmetics, food and plant tissue culture. A number of activities have been observed in each sector with vast area of research on flavonoids. PMID:24182323

  11. Recent advances in VECSELs

    NASA Astrophysics Data System (ADS)

    Rahimi-Iman, Arash

    2016-09-01

    Within the last two decades, vertical-external-cavity surface-emitting lasers (VECSELs) have attracted rising interest from both industry and science. They have proven to be versatile lasers which can be specifically designed for research and applications that require a particular regime of operation. Various emission schemes ranging from narrow-linewidth emission, pulsed light or multimode emission to a frequency-converted output are feasible owing to remarkable device features. Being composed of a semiconductor gain mirror and an external cavity, not only is a unique access to high-brightness output and a high-beam quality is provided, but also wavelength flexibility. Moreover, the exploitation of intra-cavity frequency conversion further extends the accessible spectral range from the ultraviolet (UV) to the terahertz (THz). In this work, recent advances in the field of VECSELs are highlighted.

  12. Recent Advances in Voltammetry.

    PubMed

    Batchelor-McAuley, Christopher; Kätelhön, Enno; Barnes, Edward O; Compton, Richard G; Laborda, Eduardo; Molina, Angela

    2015-06-01

    Recent progress in the theory and practice of voltammetry is surveyed and evaluated. The transformation over the last decade of the level of modelling and simulation of experiments has realised major advances such that electrochemical techniques can be fully developed and applied to real chemical problems of distinct complexity. This review focuses on the topic areas of: multistep electrochemical processes, voltammetry in ionic liquids, the development and interpretation of theories of electron transfer (Butler-Volmer and Marcus-Hush), advances in voltammetric pulse techniques, stochastic random walk models of diffusion, the influence of migration under conditions of low support, voltammetry at rough and porous electrodes, and nanoparticle electrochemistry. The review of the latter field encompasses both the study of nanoparticle-modified electrodes, including stripping voltammetry and the new technique of 'nano-impacts'. PMID:26246984

  13. Recent Advances in Voltammetry

    PubMed Central

    Batchelor-McAuley, Christopher; Kätelhön, Enno; Barnes, Edward O; Compton, Richard G; Laborda, Eduardo; Molina, Angela

    2015-01-01

    Recent progress in the theory and practice of voltammetry is surveyed and evaluated. The transformation over the last decade of the level of modelling and simulation of experiments has realised major advances such that electrochemical techniques can be fully developed and applied to real chemical problems of distinct complexity. This review focuses on the topic areas of: multistep electrochemical processes, voltammetry in ionic liquids, the development and interpretation of theories of electron transfer (Butler–Volmer and Marcus–Hush), advances in voltammetric pulse techniques, stochastic random walk models of diffusion, the influence of migration under conditions of low support, voltammetry at rough and porous electrodes, and nanoparticle electrochemistry. The review of the latter field encompasses both the study of nanoparticle-modified electrodes, including stripping voltammetry and the new technique of ‘nano-impacts’. PMID:26246984

  14. Recent results from ANTARES

    NASA Astrophysics Data System (ADS)

    Trovato, Agata

    2015-08-01

    Operating 40 km off the coast of France since 2007, the ANTARES detector is the largest deep-sea neutrino telescope in the Northern Hemisphere with an instrumented volume of more than 0.01 cubic kilometers. It consists of an array of 885 photomultipliers detecting the Cherenkov light induced by charged leptons produced by neutrino interactions in and around the detector. The primary goal of ANTARES is to search for astrophysical neutrinos in the TeV-PeV range. This comprises generic searches for any diffuse cosmic neutrino flux as well as more specific searches for astrophysical galactic and extragalactic sources. The search program also includes multi-messenger analyses based on time and/or space coincidences with other cosmic probes. The ANTARES observatory is sensitive to a wide-range of other phenomena, from atmospheric neutrino oscillations to dark matter annihilation. In this contribution, recent results from the ANTARES neutrino telescope will be presented.

  15. Recent advances in RASopathies.

    PubMed

    Aoki, Yoko; Niihori, Tetsuya; Inoue, Shin-ichi; Matsubara, Yoichi

    2016-01-01

    RASopathies or RAS/mitogen-activated protein kinase (MAPK) syndromes are a group of phenotypically overlapping syndromes caused by germline mutations that encode components of the RAS/MAPK signaling pathway. These disorders include neurofibromatosis type I, Legius syndrome, Noonan syndrome, Noonan syndrome with multiple lentigines (formerly called LEOPARD syndrome), Costello syndrome, cardiofaciocutaneous (CFC) syndrome, Noonan-like syndrome, hereditary gingival fibromatosis and capillary malformation-arteriovenous malformation. Recently, novel gene variants, including RIT1, RRAS, RASA2, A2ML1, SOS2 and LZTR1, have been shown to be associated with RASopathies, further expanding the disease entity. Although further analysis will be needed, these findings will help to better elucidate an understanding of the pathogenesis of these disorders and will aid in the development of potential therapeutic approaches. In this review, we summarize the novel genes that have been reported to be associated with RASopathies and highlight the cardiovascular abnormalities that may arise in affected individuals. PMID:26446362

  16. XOP: Recent developments

    SciTech Connect

    Sanchez del Rio, M.; Dejus, R.J.

    1998-09-01

    XOP (X-ray OPtics utilities) is a graphical user interface (GUI) to run computer programs which calculate basic information needed by synchrotron radiation beamline scientists and engineers. It can also be used as a front-end for specific codes or packages for data analysis and data reduction (XAFS, surface crystallography, etc.). XOP contains a customized database for optical and atomic constants. It has a flexible design and new applications may be added. The capabilities of XOP including those related to simulations of crystal diffraction profiles and multilayer reflectivities are summarized. The authors discuss the most recent developments which have been included in the XOP version 2.0. A few other examples of typical calculations are: insertion device (undulator and wiggler) spectra and angular distributions, mirror and multilayer reflectivities, and crystal diffraction profiles. The computer programs are executed and the results are analyzed within the GUI which make them fast and easy to use. The XOP interface is written in the Interactive Data Language (IDL) from Research Systems Inc., and it runs on the Unix (HP, Sun, Linux, DEC-Alpha, and Silicon Graphics), and on the Windows 95/NT operating systems. It has been built with an IDL license embedded and is available under some limited conditions free of charge from the authors.

  17. Recent developments in ectoparasiticides.

    PubMed

    Taylor, M A

    2001-05-01

    The sales and use of ectoparasiticides for the control of arthropod parasites of domestic animals constitute a major sector of the global animal health market. Animals are infected by a number of parasitic insect and acarine species causing major economic losses in production livestock, intense irritation and skin disease in companion animals, or public health issues, including bites of humans or zoonotic disease transmission. Dog and cat fleas, for example, can be a serious source of both animal and human irritation, which has led to a rapid expansion in the development of flea control products. The control of ectoparasite infections of veterinary importance still relies heavily on the use of chemicals that target the arthropod nervous system. Such compounds have suffered from a number of drawbacks, including the development of resistance and concerns over human and environmental safety. The search for safer technologies has, however, been hindered by the limited number of active target sites present in arthropods and, to some degree, by the ever-increasing costs of research and development of compounds with novel modes of action.This review provides a background to the currently available groups of ectoparasiticide compounds used in veterinary medicine and highlights some of the more recent developments including the introduction of insect growth regulators and new and improved methods of product application. PMID:11352483

  18. Recent SLC developments

    SciTech Connect

    Ross, M.

    1993-04-01

    The SLAC Linear Collider (SLC) is the forerunner of a new generation of high energy accelerators. As such, it incorporates many novel features that must be fully exploited to achieve optimum performance. In this paper we present an overview of the frontiers of collider performance at SLC. Recent developments have centered on polarization, intensity and emittance preservation issues. A polarized source and spin transport system were successfully commissioned in 1992 and operated with high reliability. Practical intensity limits associated with rapid growth (<{tau}{sub S}) bunch length instabilities have been observed in the damping rings. Ring RF voltage manipulations are used to suppress the instabilities. Emittance preservation technique development has focused on controlling system-wide instabilities and improving feedback and tuning procedures. Control of instabilities of all time scales, pulse to pulse, fast and slow, is one of the most challenging aspects of the collider. The challenge is met with (1) very high level of control and automation required for general tuning and optimization, (2) real-time transport line optical correction and monitoring, (3) coupled, high level, trajectory and energy feedback, (4) high order multipole optical correction and monitoring, (5) feedback-based linac beam emittance preservation, and (6) interaction region luminosity optimization. The common thread beneath all of these is the SLC control system which must provide a level of control, diagnosis and feedback not required for simpler machines.

  19. Recent advances in SPECT

    SciTech Connect

    Tsui, Benjamin M. W.

    1998-08-28

    Single photon emission computed tomography (SPECT) is a medical imaging modality that combines conventional nuclear medicine imaging technique and methods of computed tomography (CT). From images that represent the biodistribution of the injected radiopharmaceutical in the patient, SPECT provides functional information that is unique. The first SPECT system was developed in the sixties. However, early progress of SPECT was hampered by the lack of adequate image reconstruction methods. The development of x-ray CT and image reconstruction methods in the seventies spurred a renewed interest in SPECT. In 1981, the first commercial SPECT system based on a single rotating camera was available for clinical use. Today, most modern SPECT systems consist of multiple cameras that rotate around the patients. They have better spatial resolution and higher detection efficiency as compared to the earlier single camera systems. Recently, a new generation of dual camera systems allowing for coincidence imaging of positron emitting radiopharmaceuticals has emerged in the commercial market. Additionally, new quantitative image reconstruction methods are under development. They compensate for image degrading factors including attenuation, collimator-detector blurring and scatter. Also, they result in SPECT images with improved image quality and more accurately represent the three-dimensional radioactivity distribution in the patient. Such advances in radiopharmaceuticals, instrumentation, image reconstruction, compensation methods, and clinical applications have fueled a steady growth of SPECT as an important diagnostic tool in patient management.

  20. Recent Developments in SHERPA

    SciTech Connect

    Archibald, Jennifer; Gleisberg, Tanju; Hoeche, Stefan; Krauss, Frank; Schonherr, Marek; Schumann, Steffen; Siegert, Frank; Winter, Jan; /Fermilab

    2011-11-15

    Some recent QCD-related developments in the SHERPA event generator are presented. In the past decades, event generators such as PYTHIA [1, 2] and HERWIG [3, 4] have been central for nearly all physics analyses at particle physics experiments at the high-energy frontier. This will also hold true at the LHC, where a large number of interesting signals for new particles or new phenomena (the Higgs boson or any other manifestation of the mechanism behind electro-weak symmetry breaking, supersymmetry, extra dimensions etc.) is hampered by a plethora of severe, sometimes overwhelming backgrounds. Nearly all of them are largely influenced by QCD. Therefore it seems fair to say that the success of the LHC in finding new physics may very well depend on a deep and detailed understanding of old physics, like QCD. Examples for this include, among others, the central-jet veto for the vector boson fusion channel for Higgs production or topologies, where gauge bosons emerge in association with many jets, a background for many search channels. In a reflection on increased needs by the experimental community, aiming at higher precision, incorporation of new physics models and so on, the work horses of old have undergone serious renovation efforts, resulting in new, improved versions of the respective codes, namely PYTHIA8 [5] and HERWIG++ [6]. In addition a completely new code, SHERPA [7], has been constructed and is in the process of maturing. The status of this code is the topic of this contribution. SHERPA's hallmark property is the inclusion of higher-order tree-level QCD contributions, leading to an improved modelling of jet production. They are introduced through a full-fledged matrix element generator, AMEGIC++ [8], which is capable of generating matrix elements and corresponding phase space mappings for processes with multi-particle final states in various models, including the Standard Model, anomalous gauge triple and quadruple couplings according to [9, 10], the Minimal

  1. Recently Identified Forms of Epidermolysis Bullosa.

    PubMed

    McGrath, John A

    2015-12-01

    Epidermolysis bullosa (EB) comprises a collection of clinically diverse inherited blistering diseases that affect the skin and, in some subtypes, mucous membranes and other organs. Currently classified into four main subtypes (EB simplex, junctional EB, dystrophic EB, and Kindler syndrome, mainly based on the level of skin cleavage), the spectrum of EB extends to more than 30 clinical subtypes with pathogenic mutations in at least 18 distinct genes. This review focuses on three recent additions to variants of EB: all are autosomal recessive, and result from mutations in either DST-e (coding for epidermal dystonin, also known as the 230 kDa bullous pemphigoid antigen, BP230), EXPH5 (coding for exophilin-5, also known as Slac2-b), or ITGA3 (coding for the integrin alpha-3 subunit). Each of these new forms of EB is reviewed with respect to the initial gene discovery, clinical features, the current mutation database, and skin pathology. Awareness of these recently described forms of EB is helpful in the clinical evaluation of patients with EB and in defining genotype-phenotype correlation for inherited blistering skin diseases. PMID:26719633

  2. Recently Identified Forms of Epidermolysis Bullosa

    PubMed Central

    2015-01-01

    Epidermolysis bullosa (EB) comprises a collection of clinically diverse inherited blistering diseases that affect the skin and, in some subtypes, mucous membranes and other organs. Currently classified into four main subtypes (EB simplex, junctional EB, dystrophic EB, and Kindler syndrome, mainly based on the level of skin cleavage), the spectrum of EB extends to more than 30 clinical subtypes with pathogenic mutations in at least 18 distinct genes. This review focuses on three recent additions to variants of EB: all are autosomal recessive, and result from mutations in either DST-e (coding for epidermal dystonin, also known as the 230 kDa bullous pemphigoid antigen, BP230), EXPH5 (coding for exophilin-5, also known as Slac2-b), or ITGA3 (coding for the integrin alpha-3 subunit). Each of these new forms of EB is reviewed with respect to the initial gene discovery, clinical features, the current mutation database, and skin pathology. Awareness of these recently described forms of EB is helpful in the clinical evaluation of patients with EB and in defining genotype-phenotype correlation for inherited blistering skin diseases. PMID:26719633

  3. The DA{phi}NE-Light Facility

    SciTech Connect

    Burattini, Emilio; Cinque, Gianfelice; Dabagov, Sultan; Grilli, Antonio; Marcelli, Augusto; Pace, Elisabetta; Piccinini, Massimo; Raco, Agostino; Monti, Francesca

    2004-05-12

    The new Synchrotron Radiation facility at Frascati exploits the intense photon emission from DA{phi}NE, the 0,51 GeV storage ring circulating over 1 A of electrons. Among the three beamlines commissioned, the Synchrotron INfrared Beamline At Da{phi}ne (SINBAD) is fully operational by a brilliant SR beam spanning the entire IR. Recently, the soft X-ray beamline has been characterized and, once implemented the double-crystal monocromator, X-ray Absorption Spectroscopy is applied on material standards in the distinguishing energy region below 4 keV. An UltraViolet line, presently dedicated to photobiology dosimetry, has also given first results on cell irradiation in the UVB band.

  4. Recent advances in silage microbiology

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Recent advances in our understanding of silage microbiology are reviewed. The ability to extract microbial DNA from silages, amplify portions of DNA, and use the amplified regions to identify strains of microorganisms is at the core of the changes occurring recently in silage microbiology. These dev...

  5. Recent advance in carrot genomics

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In recent years there has been an effort towards the development of genomic resources in carrot. The number of available sequences for carrot in public databases has increased recently. This has allowed the design of SSRs markers, COS markers and a high-throughput SNP assay for genotyping. Additiona...

  6. Recent development in organic scintillators

    NASA Technical Reports Server (NTRS)

    Horrocks, D. L.; Wirth, H. O.

    1969-01-01

    Discussion on recent developments of organic scintillators includes studies of organic compounds that form glass-like masses which scintillate and are stable at room temperature, correlations between molecular structure of organic scintillators and self-quenching, recently developed fast scintillators, and applications of liquid-scintillation counters.

  7. Recent Discoveries and Bible Translation.

    ERIC Educational Resources Information Center

    Harrelson, Walter

    1990-01-01

    Discusses recent discoveries for "Bible" translation with a focus on the "Dead Sea Scrolls." Examines recent discoveries that provide direct support for alternative reading of biblical passages and those discoveries that have contributed additional insight to knowledge of cultural practices, especially legal and religious practices. (DB)

  8. NPOI: recent technology and science

    NASA Astrophysics Data System (ADS)

    Benson, James A.; Hutter, Donald J.; Johnston, Kenneth J.; Zavala, Robert T.; White, Nathaniel M.; Pauls, Thomas A.; Gilbreath, G. C.; Armstrong, J. T.; Hindsley, Robert B.

    2004-10-01

    We describe recent science projects that the Navy Prototype Optical Interferometer (NPOI) scientific staff and collaborators are pursuing. Recent results from the wide angle astrometric program and imaging programs (rapid rotators, binaries and Be stars) will be summarized. We discuss some of the technology that enables the NPOI to operate routinely as an observatory astronomical instrument.

  9. Recent advances in laparoscopic surgery.

    PubMed

    Lee, Wei-Jei; Chan, Chien-Pin; Wang, Bing-Yen

    2013-02-01

    Laparoscopic surgery has been widely adopted and new technical innovation, procedures and evidence based knowledge are persistently emerging. This review documents recent major advancements in laparoscopic surgery. A PubMed search was made in order to identify recent advances in this field. We reviewed the recent data on randomized trials in this field as well as papers of systematic review. Laparoscopic cholecystectomy is the most frequently performed procedure, followed by laparoscopic bariatric surgery. Although bile duct injuries are relatively uncommon (0.15%-0.6%), intraoperative cholangiography still plays a role in reducing the cost of litigation. Laparoscopic bariatric surgery is the most commonly performed laparoscopic gastrointestinal surgery in the USA, and laparoscopic Nissen fundoplication is the treatment of choice for intractable gastroesophageal reflux disease. Recent randomized trials have demonstrated that laparoscopic gastric and colorectal cancer resection are safe and oncologically correct procedures. Laparoscopic surgery has also been widely developed in hepatic, pancreatic, gynecological and urological surgery. Recently, SILS and robotic surgery have penetrated all specialties of abdominal surgery. However, evidence-based medicine has failed to show major advantages in SILS, and the disadvantage of robotic surgery is the high costs related to purchase and maintenance of technology. Laparoscopic surgery has become well developed in recent decades and is the choice of treatment in abdominal surgery. Recently developed SILS techniques and robotic surgery are promising but their benefits remain to be determined. PMID:23126424

  10. Trojan Horse Method: Recent Experiments

    SciTech Connect

    Cherubini, S.; Spitaleri, C.; Crucilla, V.; Gulino, M.; La Cognata, M.; Lamia, L.; Pizzone, R. G.; Romano, S.; Tudisco, S.; Tumino, A.; Mukhamedzhanov, A.; Trache, L.; Tribble, R.; Rolfs, C.; Typel, S.

    2006-07-12

    The Trojan Horse Method allows for the measurements of cross sections in nuclear reactions between charged particles at astrophysical energies. The basic features of the method are discussed and recent applications are presented.

  11. Recent progress of quantum annealing

    SciTech Connect

    Suzuki, Sei

    2015-03-10

    We review the recent progress of quantum annealing. Quantum annealing was proposed as a method to solve generic optimization problems. Recently a Canadian company has drawn a great deal of attention, as it has commercialized a quantum computer based on quantum annealing. Although the performance of quantum annealing is not sufficiently understood, it is likely that quantum annealing will be a practical method both on a conventional computer and on a quantum computer.

  12. Studying and Working Abroad. Leonardo da Vinci Series: Good Practices.

    ERIC Educational Resources Information Center

    Commission of the European Communities, Brussels (Belgium). Directorate-General for Education and Culture.

    This document profiles recent successful examples of students studying and working abroad as part of the European Commission's Leonardo da Vinci program, which is designed to give students across the European Union the opportunity to experience vocational training in a foreign country. The following examples are presented: (1) 3 Finnish students…

  13. Migration of ATLAS PanDA to CERN

    NASA Astrophysics Data System (ADS)

    Stewart, Graeme Andrew; Klimentov, Alexei; Koblitz, Birger; Lamanna, Massimo; Maeno, Tadashi; Nevski, Pavel; Nowak, Marcin; Emanuel De Castro Faria Salgado, Pedro; Wenaus, Torre

    2010-04-01

    The ATLAS Production and Distributed Analysis System (PanDA) is a key component of the ATLAS distributed computing infrastructure. All ATLAS production jobs, and a substantial amount of user and group analysis jobs, pass through the PanDA system, which manages their execution on the grid. PanDA also plays a key role in production task definition and the data set replication request system. PanDA has recently been migrated from Brookhaven National Laboratory (BNL) to the European Organization for Nuclear Research (CERN), a process we describe here. We discuss how the new infrastructure for PanDA, which relies heavily on services provided by CERN IT, was introduced in order to make the service as reliable as possible and to allow it to be scaled to ATLAS's increasing need for distributed computing. The migration involved changing the backend database for PanDA from MySQL to Oracle, which impacted upon the database schemas. The process by which the client code was optimised for the new database backend is discussed. We describe the procedure by which the new database infrastructure was tested and commissioned for production use. Operations during the migration had to be planned carefully to minimise disruption to ongoing ATLAS offline computing. All parts of the migration were fully tested before commissioning the new infrastructure and the gradual migration of computing resources to the new system allowed any problems of scaling to be addressed.

  14. Recent geologic activity on Mercury

    NASA Astrophysics Data System (ADS)

    Xiao, Z.; Strom, R. G.; Blewett, D. T.; Solomon, S. C.; Head, J. W.; Watters, T. R.; Chabot, N. L.; Banks, M. E.; Chapman, C. R.

    2011-12-01

    Since the MESSENGER spacecraft was inserted into orbit about Mercury in March 2011, global and targeted high-resolution image data sets have been acquired. These images support the conclusion that internal geological activity on Mercury did not end early in planetary history, as had generally been previously thought, but continued to geologically recent times. Three lines of evidence point to recent geological activity on Mercury. (1) There are smooth plains with surface areas up to 1.5×105 km2 that postdate young (morphological class 1) craters, indicating probable Kuiperian-aged volcanism. No volcanic vents, fissures, or flow fronts have been identified on these plains, suggesting that they are products of low-viscosity lavas, consistent with komatiite-like compositions of large areas on Mercury indicated by MESSENGER X-Ray Spectrometer observations. (2) Young lobate scarps transect class 1 craters as large as 30 km in diameter, indicating comparably recent crustal contraction. (3) A number of fresh-appearing, high-reflectance, irregularly shaped and rimless shallow depressions interpreted as pyroclastic vents have few superposed craters, suggesting that they have been recently active. Growing evidence from geological and geochemical observations indicates that Mercury's interior contains a higher abundance of volatile materials than was previously appreciated. Together these findings support the inference that Mercury experienced relatively recent volcanism and tectonic deformation, and the possibility that the planet is geologically active today cannot be discounted.

  15. Recent Developments in Colorectal Imaging

    PubMed Central

    Pickhardt, Perry J.

    2014-01-01

    Purpose of review The aim of this review is to provide an update on important recent advances in radiologic colorectal imaging, with emphasis on detection, staging, and surveillance of colorectal neoplasia. Recent findings Colorectal imaging advances with magnetic resonance (MR), CT colonography (CTC), and positron emission tomography (PET) over the past year or so have been substantial. Progress in MR imaging for rectal cancer was most notable in terms of assessment of response to neoadjuvant therapy. Continued maturation and clinical validation of CTC was observed for the evaluation of advanced neoplasia, among other areas. Multimodality approaches to colorectal imaging that incorporate functional PET data have also made impressive strides forward. Summary Recent advances in cross-sectional and functional radiologic imaging of the colorectum will positively impact the clinical capabilities for noninvasive evaluation of colorectal neoplasia PMID:25394232

  16. Recent advances in ordered intermetallics

    SciTech Connect

    Liu, C.T.

    1992-12-31

    This paper briefly summarizes recent advances in intermetallic research and development. Ordered intermetallics based on aluminides and silicides possess attractive properties for structural applications at elevated temperatures in hostile environments; however, brittle fracture and poor fracture resistance limit their use as engineering materials in many cases. In recent years, considerable efforts have been devoted to the study of the brittle fracture behavior of intermetallic alloys; as a result, both intrinsic and extrinsic factors governing brittle fracture have been identified. Recent advances in first-principles calculations and atomistic simulations further help us in understanding atomic bonding, dislocation configuration, and alloying effects in intermetallics. The basic understanding has led to the development of nickel, iron, and titanium aluminide alloys with improved mechanical and metallurgical properties for structural use. Industrial interest in ductile intermetallic alloys is high, and several examples of industrial involvement are mentioned.

  17. Recent Advances in Conformal Gravity

    NASA Astrophysics Data System (ADS)

    O'Brien, James; Chaykov, Spasen

    2016-03-01

    In recent years, significant advances have been made in alternative gravitational theories. Although MOND remains the leading candidate among the alternative models, Conformal Gravity has been studied by Mannheim and O'Brien to solve the rotation curve problem without the need for dark matter. Recently, Mannheim, O'Brien and Chaykov have begun solving other gravitational questions in Conformal Gravity. In this presentation, we highlight the new work of Conformal Gravity's application to random motions of clusters (the original Zwicky problem), gravitational bending of light, gravitational lensing and a very recent survey of dwarf galaxy rotation curves. We will show in each case that Conformal Gravity can provide an accurate explanation and prediction of the data without the need for dark matter. Coupled with the fact that Conformal Gravity is a fully re-normalizable metric theory of gravity, these results help to push Conformal Gravity onto a competitive stage against other alternative models.

  18. Recent Advances in Kawasaki Disease

    PubMed Central

    Kim, Kyu Yeun

    2016-01-01

    Kawasaki disease (KD) is characterized with acute systemic vasculitis, occurs predominantly in children between 6 months to 5 years of age. Patients with this disease recover well and the disease is self-limited in most cases. Since it can lead to devastating cardiovascular complications, KD needs special attention. Recent reports show steady increases in the prevalence of KD in both Japan and Korea. However, specific pathogens have yet to be found. Recent advances in research on KD include searches for genetic susceptibility related to KD and research on immunopathogenesis based on innate and acquired immunity. Also, search for etiopathogenesis and treatment of KD has been actively sought after using animal models. In this paper, the recent progress of research on KD was discussed. PMID:26632378

  19. Recent Patents in Oncolytic Virotherapy.

    PubMed

    Ahmad, Tauqeer; Venkataraman, Srividhya; AbouHaidar, Mounir; Hefferon, Kathleen L

    2016-01-01

    Recent innovative and advanced developments in the diagnosis and treatment of human diseases as well as enhanced in-depth understanding of virus molecular biology have opened novel avenues with respect to the patent landscape. Included are viruses utilized in the development of anticancer agents, agents that are employed against the spread of infectious viral diseases, RNA silencing agents and virus-derived expression vectors that can be used for over-expression of therapeutic proteins or as gene therapy vehicles. The current review describes several recent patents pertaining to virus sequences and their medical and biotechnological applications. PMID:26961667

  20. Recent Advances in Nickel Catalysis

    PubMed Central

    Tasker, Sarah Z.; Standley, Eric A.; Jamison, Timothy F.

    2015-01-01

    Preface The field of nickel catalysis has made tremendous advances in the past decade. There are several key properties of nickel that have allowed for a broad range of innovative reaction development, such as facile oxidative addition and ready access to multiple oxidation states. In recent years, these properties have been increasingly understood and leveraged to perform transformations long considered exceptionally challenging. Herein, we discuss some of the most recent and significant developments in homogeneous nickel catalysis with an emphasis on both synthetic outcome and mechanism. PMID:24828188

  1. Recent advances in wavelet technology

    NASA Technical Reports Server (NTRS)

    Wells, R. O., Jr.

    1994-01-01

    Wavelet research has been developing rapidly over the past five years, and in particular in the academic world there has been significant activity at numerous universities. In the industrial world, there has been developments at Aware, Inc., Lockheed, Martin-Marietta, TRW, Kodak, Exxon, and many others. The government agencies supporting wavelet research and development include ARPA, ONR, AFOSR, NASA, and many other agencies. The recent literature in the past five years includes a recent book which is an index of citations in the past decade on this subject, and it contains over 1,000 references and abstracts.

  2. Recent progress in tidal modeling

    NASA Technical Reports Server (NTRS)

    Vial, F.; Forbes, J. M.

    1989-01-01

    Recent contributions to tidal theory during the last five years are reviewed. Specific areas where recent progress has occurred include: the action of mean wind and dissipation on tides, interactions of other waves with tides, the use of TGCM in tidal studies. Furthermore, attention is put on the nonlinear interaction between semidiurnal and diurnal tides. Finally, more realistic thermal excitation and background wind and temperature models have been developed in the past few years. This has led to new month-to-month numerical simulations of the semidiurnal tide. Some results using these models are presented and compared with ATMAP tidal climatologies.

  3. Henrique da Rocha Lima.

    PubMed

    Bernardes Filho, Fred; Avelleira, João Carlos Regazzi

    2015-01-01

    Brazilian physician and researcher Henrique da Rocha Lima was born in 1879 in the city of Rio de Janeiro, where he studied medicine and obtained the degree of M.D. in 1901. He specialized in Clinical Medicine in Germany and was the ambassador in European countries of the scientific medicine that emerged from the Oswaldo Cruz Institute in the early twentieth century. Rocha Lima has discovered the causative agent of typhus and had a major contribution to the studies of yellow fever, Chagas disease, Carrión's disease and histoplasmosis. His genius, his research and his discoveries projected his name, and, with it, the image of Brazil in the international scientific scene. PMID:26131867

  4. Henrique da Rocha Lima*

    PubMed Central

    Bernardes Filho, Fred; Avelleira, João Carlos Regazzi

    2015-01-01

    Brazilian physician and researcher Henrique da Rocha Lima was born in 1879 in the city of Rio de Janeiro, where he studied medicine and obtained the degree of M.D. in 1901. He specialized in Clinical Medicine in Germany and was the ambassador in European countries of the scientific medicine that emerged from the Oswaldo Cruz Institute in the early twentieth century. Rocha Lima has discovered the causative agent of typhus and had a major contribution to the studies of yellow fever, Chagas disease, Carrión’s disease and histoplasmosis. His genius, his research and his discoveries projected his name, and, with it, the image of Brazil in the international scientific scene. PMID:26131867

  5. Telematics Simulation: Recent Developments & Issues.

    ERIC Educational Resources Information Center

    Sutherland, Janet; Ekker, Knut; Morgan, Konrad; Crookall, David; Carbonell, Amparo Garcia

    Recent developments in Internet technologies have enabled new, more flexible forms of telematic simulation and have raised issues that were not considered in the early days of networked learning. Ultimately, these questions revolve around: (1) the learning cost-effectiveness of telematic simulation (quality and quantity of learning as opposed to…

  6. Recent Results from the Tevatron

    SciTech Connect

    Demorden, L.

    1998-06-01

    We review recent results from fixed-target and collider experiments at the Fermilab Tevatron. Among the topics discussed are jet production rates, {alpha}{sub S} measurements, the {anti d}/{anti u} ratio in the proton sea, diffraction, heavy quark physics and leptoquark searches.

  7. DNA demethylation pathways: recent insights

    Technology Transfer Automated Retrieval System (TEKTRAN)

    DNA methylation is a major epigenetic regulatory mechanism for gene expression and cell differentiation. While methyltransferases mediate cytosine methylation, until recently, it was still less clear how unmethylated regions in mammalian genomes are protected from de novo methylation and whether ac...

  8. Recent Leaders in American Education

    ERIC Educational Resources Information Center

    Ediger, Marlow

    2012-01-01

    The writer would like to suggest eight recent leaders who have contributed much in assisting teachers to help pupils achieve well. These educators are largely from the twentieth century. Their contributions appear in educational journals, teacher education textbooks on the university level, as well as professional talks presented at international,…

  9. Recent Research on Ego Development.

    ERIC Educational Resources Information Center

    Loevinger, Jane

    One conception of ego development and recent research on its outcome are presented. The infant first asserts his selfhood through demand and negation. This is the Impulsive stage. The next stage is the Ritual-hedonistic stage, in which controls are supplied by ritual observances, and reward and punishment remain important sanctions. The next…

  10. Recent Literature on Government Information

    ERIC Educational Resources Information Center

    Sleeman, Bill

    2004-01-01

    The purpose of this column is to provide government information scholars and students with a broad overview of recent publications about government information from the literature of librarianship, archives, information technology management, public policy, and law. Given the volume of literature produced in this field, a columnist cannot claim…

  11. Recent Literature on Government Information

    ERIC Educational Resources Information Center

    Sleeman, Bill

    2004-01-01

    The purpose of this column is to provide government information scholars and students with a broad overview of recent publications about government information from the literature of librarianship, archives, information technology management, public policy and law. Given the volume of literature produced in this field, a columnist cannot claim…

  12. John Eliot in Recent Scholarship.

    ERIC Educational Resources Information Center

    Cogley, Richard W.

    1990-01-01

    Reviews the recent literature on John Eliot--seventeenth-century Massachusetts missionary, minister, and millenarian. Examines disagreements between Alden Vaughan's and Francis Jennings's interpretations of Eliot's missionary writings and Puritan-Indian relations. Discusses James Axtell's ethnohistorical interpretation of Eliot. Emphasizes the…

  13. Some recent thinking on personhood.

    PubMed

    Smith, A L

    2000-04-01

    This essay surveys four recent theological works on the issue of personhood: John F. Crosby's The Selfhood of the Human Person, Stanley Rudman's Concepts of Person and Christian Ethics, Metropolitan Hierotheos Vlachos' The Person in the Orthodox Tradition, and James Walter's What is a Person? An Ethical Exploration. PMID:12166487

  14. Recent Trends in Karst Geomorphology.

    ERIC Educational Resources Information Center

    Palmer, Arthur N.

    1984-01-01

    Recent trends related to the karst processes and the evolution of karst landscapes are discussed. The hydrochemical processes responsible for the origin of karst are expanded on to illustrate the present scope of karst studies. These geomorphological studies are combined with concepts and techniques from hydraulics, chemistry, and mathematics. (JN)

  15. Recent advances in sterol research

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Since 1970, the AOCS has been a regular host to the sterol symposia. The 2008 Sterol Symposium, “Recent Advances in Sterol Research,” was held at the AOCS Annual Meeting in Seattle, Washington. This year the symposium held special significance, for it hosted the presentation of the fourth G.J. Schro...

  16. Recent results from DORIS II

    SciTech Connect

    Bloom, E.D.

    1985-01-01

    This report contains a brief review of recent results from the ARGUS and Crystal Ball experiments at DORIS II, concentrating on UPSILON(1S) and UPSILON(2S) spectroscopy with a short foray into ..gamma gamma.. physics. 18 refs., 10 figs.

  17. Recent Advances of VCSEL Photonics

    NASA Astrophysics Data System (ADS)

    Koyama, Fumio

    2006-12-01

    A vertical-cavity surface emitting laser (VCSEL) was invented 30 years ago. A lot of unique features can be expected, such as low-power consumption, wafer-level testing, small packaging capability, and so on. The market of VCSELs has been growing up rapidly in recent years, and they are now key devices in local area networks using multimode optical fibers. Also, long wavelength VCSELs are currently attracting much interest for use in single-mode fiber metropolitan area and wide area network applications. In addition, a VCSEL-based disruptive technology enables various consumer applications such as a laser mouse and laser printers. In this paper, the recent advance of VCSEL photonics will be reviewed, which include the wavelength extension of single-mode VCSELs and their wavelength integration/control. Also, this paper explores the potential and challenges for new functions of VCSELs toward optical signal processing.

  18. Recent Development of Metallic Materials

    SciTech Connect

    Liu, C.T.; Nieh, T.G.

    1999-07-02

    Metallic materials play a vital role in the development of advanced engineering systems for industrial applications. In this paper, the recent development of two metallic alloy families will be briefly reviewed: (1) ordered intermetallics, and (2) bulk metallic glasses. Ordered intermetallic alloys based on aluminides and silicides possess many promising properties for structural use at elevated temperatures in hostile environments. This is because these alloys have excellent oxidation and corrosion resistance, high temperature strength, and relatively low material density. Bulk metallic glasses containing multiple alloying elements constitute a new and exciting class of metallic materials with attractive mechanical, chemical, and magnetic properties for structural and functional use. Recent development indicates that bulk metallic glasses with high glass forming ability can be readily produced by conventional melting and casting techniques.

  19. Recent advances in Asian rhinoplasty.

    PubMed

    Jin, Hong-Ryul; Won, Tae-Bin

    2011-04-01

    Asian rhinoplasty is an expanding topic in the field of rhinoplasty. Although the main principles of various rhinoplasty techniques apply equally to the Asian nose, Asian rhinoplasty is unique owing to its different anatomy and ethnicity. In recent years there have been some noteworthy developments in Asian rhinoplasty. Traditional techniques using alloplastic implants with endonasal approach are changing due to the advent of new beauty concept, introduction of new techniques, and development of newly improved materials. In this review, we will highlight some of the recent advances of Asian rhinoplasty with emphasis on dorsal augmentation, advances in implant material and tip surgery using autologous cartilage. Finally with increase of revision cases, issues relevant to revision rhinoplasty in Asians will be addressed. PMID:20728295

  20. Recent developments in biased agonism

    PubMed Central

    Wisler, James W.; Xiao, Kunhong; Thomsen, Alex R.B.; Lefkowitz, Robert J.

    2014-01-01

    The classic paradigm of G protein-coupled receptor (GPCR) activation was based on the understanding that agonist binding to a receptor induces or stabilizes a conformational change to an “active” conformation. In the past decade, however, it has been appreciated that ligands can induce distinct “active” receptor conformations with unique downstream functional signaling profiles. Building on the initial recognition of the existence of such “biased ligands”, recent years have witnessed significant developments in several areas of GPCR biology. These include increased understanding of structural and biophysical mechanisms underlying biased agonism, improvements in characterization and quantification of ligand efficacy, as well as clinical development of these novel ligands. Here we review recent major developments in these areas over the past several years. PMID:24680426

  1. Illnesses among recently immigrated children.

    PubMed

    Schwarzwald, Heidi

    2005-04-01

    The number of children immigrating to the United States has increased steadily during the last decade. American families are adopting a significant portion of these children, more than 20,000. Recently immigrated children face many different health risks when compared to children born in the United States. They are subject to many infectious diseases no longer seen commonly in the United States such as malaria, tuberculosis, and HIV. They are more likely to have inadequate immunity to vaccine-preventable illnesses. Recent immigrants have a higher likelihood of having malnutrition and developmental delay. Finally, many will have suffered psychological trauma in either institutions or refugee camps. These children require specialized testing, care, and treatment in the pediatric office. PMID:15825138

  2. Recent Advances in Azaborine Chemistry

    PubMed Central

    Campbell, Patrick G.; Marwitz, Adam J. V.

    2013-01-01

    The chemistry of organoboron compounds has been primarily dominated by their use as powerful reagents in synthetic organic chemistry. Recently, the incorporation of boron as part of a functional target structure has emerged as a useful way to generate diversity in organic compounds. A commonly applied strategy is the replacement of a CC unit with its isoelectronic BN unit. In particular, the BN/CC isosterism of the ubiquitous arene motif has undergone a renaissance in the past decade. The parent molecule of the 1,2-dihydro-1,2-azaborine family has now been isolated. New mono- and polycyclic BN heterocycles have been synthesized for potential use in biomedical and materials science applications. This review is a tribute to Dewar's first synthesis of a monocyclic 1,2-dihydro-1,2-azaborine 50 years ago and discusses recent advances in the synthesis and characterization of carbon(C)-boron(B)-nitrogen(N)-containing heterocycles. PMID:22644658

  3. Recent imaging advances in neurology.

    PubMed

    Rocchi, Lorenzo; Niccolini, Flavia; Politis, Marios

    2015-09-01

    Over the recent years, the application of neuroimaging techniques such as magnetic resonance imaging (MRI) and positron emission tomography (PET) has considerably advanced the understanding of complex neurological disorders. PET is a powerful molecular imaging tool, which investigates the distribution and binding of radiochemicals attached to biologically relevant molecules; as such, this technique is able to give information on biochemistry and metabolism of the brain in health and disease. MRI uses high intensity magnetic fields and radiofrequency pulses to provide structural and functional information on tissues and organs in intact or diseased individuals, including the evaluation of white matter integrity, grey matter thickness and brain perfusion. The aim of this article is to review the most recent advances in neuroimaging research in common neurological disorders such as movement disorders, dementia, epilepsy, traumatic brain injury and multiple sclerosis, and to evaluate their contribution in the diagnosis and management of patients. PMID:25808503

  4. Recent developments in neutrino physics

    SciTech Connect

    Garvey, G.T.

    1991-01-01

    I shall attempt to summarize recent developments in the experimental situation in neutrino physics. The paper will deal with recent results, drawing on either published work or research that has been presented in preprint form, as there is an adequate supply of interesting and controversial data restricting oneself to these generally more reliable sources. The discussion of the theoretical implication of these experimental results will be presented in the following paper by Boris Kayser. The topics to be covered in this presentation are: direct measurements of {bar {nu}}{sub e} mass via beta endpoint studies; status of solar neutrino observations; status of 17-keV neutrino'' reports; and the use of {nu}p elastic scattering to determine the strange quark'' content of the proton. 2 refs., 15 figs., 9 tabs.

  5. Recent DIII-D results

    SciTech Connect

    Petersen, P.I.

    1994-07-01

    This paper summarizes the recent DIII-D experimental results and the development of the relevant hardware systems. The DIII-D program focuses on divertor solutions for next generation tokamaks such as International Thermo-nuclear Experimental Reactor (ITER) and Tokamak Physics Experiment (TPX), and on developing configurations with enhanced confinement and stability properties that will lead to a more compact and economical fusion reactor. The DIII-D program carries out this research in an integrated fashion.

  6. Recent advances in Takayasu arteritis.

    PubMed

    Terao, Chikashi; Yoshifuji, Hajime; Mimori, Tsuneyo

    2014-03-01

    Takayasu arteritis (TAK) is a relatively rare systemic vasculitis mainly affecting the aorta and its large branches. While patients with TAK are more frequently observed in Asian countries, we can find patients with TAK all over the world. This limited number of patients has made it difficult to collect large numbers of patients and perform detailed studies. However, recent progresses have led to the identification of susceptibility genes and novel susceptibility human leukocyte antigen (HLA) alleles as well as accumulation of clues for the pathophysiology of TAK. IL12B was shown to be a susceptibility gene beyond ethnicity. MLX and FCGR2A/3A were shown to be associated with TAK in Japanese and Turkish/American populations, respectively. HLA-B*52:01 and *67:01 are susceptibility alleles to TAK, and the 171st and 67th amino acid residues of HLA-B protein are suggested important for TAK susceptibility. HLA-DQB1/DRB1 is recently reported as an independent susceptibility locus. Although there are no standardized serum markers or composite measures for disease activity of TAK, Japanese and Italian groups showed pentraxin 3 as a novel biomarker for detecting and monitoring patients with TAK. Recently, an Indian group proposed a novel scoring system called ITAS to evaluate disease activity of TAK. Standardization of assessing disease activity would lead to clinical studies with high quality. Several groups reported results of treatment for refractory TAK with biological agents targeting tumor necrosis factor or interleukin-6R. The recent accumulation of research data should improve understanding of the basic pathophysiology of TAK and lead to better management of patients with TAK. PMID:24548718

  7. Recent work on gaseous detonations

    NASA Astrophysics Data System (ADS)

    Nettleton, M. A.

    The paper reviews recent progress in the field of gaseous detonations, with sections on shock diffraction and reflection, the transition to detonation, hybrid, spherically-imploding, and galloping and stuttering fronts, their structure, their transmission and quenching by additives, the critical energy for initiation and detonation of more unusual fuels. The final section points out areas where our understanding is still far from being complete and contains some suggestions of ways in which progress might be made.

  8. Molten salt spectroelectrochemistry: recent developments

    SciTech Connect

    Mamantov, G.; Chapman, D.M.; Harward, B.L.; Klatt, L.N.; Smith, G.P.

    1985-01-01

    Molten salt spectroelectrochemistry will be reviewed in this paper. UV-visible transmission, infrared reflectance, resonance and normal Raman, and electron spin resonance spectroelectrochemistry have been used for molten salt studies. Two recent applications of uv-visible transmission spectroelectrochemistry to studies of organic and inorganic solutes in molten SbCl/sub 3/-AlCl/sub 3/-N-(1-butyl)pyridinium chloride and AlCl/sub 3/-NaCl will be described.

  9. Recent developments in complex scaling

    SciTech Connect

    Rescigno, T.N.

    1980-12-15

    Some recent developments in the use of complex basis function techniques to study resonance as well as certain types of non-resonant, scattering phenomena are discussed. Complex scaling techniques and other closely related methods have continued to attract the attention of computational physicists and chemists and have now reached a point of development where meaningful calculations on many-electron atoms and molecules are beginning to appear feasible.

  10. Recent QCD results from CDF

    SciTech Connect

    Huston, J. |; CDF Collaboration

    1994-01-01

    CDF has recently concluded a very successful 1992--93 data run in which an integrated luminosity of 21.3 pb {sup {minus}1} was written to tape. The large data sample allows for a greater discovery potential for new phenomena and for better statistical and systematic precision in analysis of conventional physics. This paper summarizes some of the new results from QCD analyses for this run.

  11. Recent Progress in Superstring Theory

    NASA Astrophysics Data System (ADS)

    Schwarz, John H.

    2002-12-01

    Superstring theory has continued to develop at a rapid clip in the past few years. Following a quick review of some of the major discoveries prior to 1998, this talk focuses on a few of the more recent developments. The topics I have chosen to present are 1) the use of K-theory to classify conserved charges carried by D-branes; 2) tachyon condensation on unstable D-brane systems; and 3) an introduction to noncommutative field theories and their solitons.

  12. Recent developments in multilevel optimization

    NASA Technical Reports Server (NTRS)

    Vanderplaats, Garret N.; Kim, D.-S.

    1989-01-01

    Recent developments in multilevel optimization are briefly reviewed. The general nature of the multilevel design task, the use of approximations to develop and solve the analysis design task, the structure of the formal multidiscipline optimization problem, a simple cantilevered beam which demonstrates the concepts of multilevel design and the basic mathematical details of the optimization task and the system level are among the topics discussed.

  13. Recent Advances in Agglomerated Multigrid

    NASA Technical Reports Server (NTRS)

    Nishikawa, Hiroaki; Diskin, Boris; Thomas, James L.; Hammond, Dana P.

    2013-01-01

    We report recent advancements of the agglomerated multigrid methodology for complex flow simulations on fully unstructured grids. An agglomerated multigrid solver is applied to a wide range of test problems from simple two-dimensional geometries to realistic three- dimensional configurations. The solver is evaluated against a single-grid solver and, in some cases, against a structured-grid multigrid solver. Grid and solver issues are identified and overcome, leading to significant improvements over single-grid solvers.

  14. Recent advances for FLAP inhibitors.

    PubMed

    Pettersen, Daniel; Davidsson, Öjvind; Whatling, Carl

    2015-07-01

    A number of FLAP inhibitors have been progressed to clinical trials for respiratory and other inflammatory indications but so far no drug has reached the market. With this Digest we assess the opportunity to develop FLAP inhibitors for indications beyond respiratory disease, and in particular for atherosclerotic cardiovascular disease. We also show how recently disclosed FLAP inhibitors have structurally evolved from the first generation FLAP inhibitors paving the way for new compound classes. PMID:26004579

  15. Recent Developments in Primary Aldosteronism.

    PubMed

    Asbach, E; Williams, T A; Reincke, M

    2016-06-01

    Primary aldosteronism (PA) is the most frequent endocrine cause of secondary arterial hypertension. Sporadic forms of PA caused mainly by an aldosterone producing adenoma (APA) or idiopathic adrenal hyperplasia (IAH) predominate; in contrast, familial forms (familial hyperaldosteronism types I, II and III) affect only a minor proportion of PA patients. Patient based registries and biobanks, international networks and next generation sequencing technologies have emerged over recent years. Somatic hot-spot mutations in the potassium channel GIRK4 (encoded by KCNJ5), in ATPases and a L-type voltage-gated calcium-channel correlate with the autonomous aldosterone production in approximately half of all APAs. The recently discovered form FH III is caused by different germline KCNJ5 mutations with variable clinical presentations and severity. Autoantibodies to the angiotensin II Type 1 receptor have been identified in patients with PA and possibly play a pathophysiological role in the development of PA. Adrenal vein sampling (AVS) represents the gold standard in differentiating unilateral and bilateral forms of PA. Recent consensus papers have tried to implement current guidelines in order to standardise the technique of AVS. New techniques like segmental AVS might allow a finer mapping of the aldosterone production within the adrenal gland. The measurement of the steroids 18-hydroxycortisol and 18-oxocortisol by liquid chromatography tandem mass spectrometry has been shown to be useful to distinguish between unilateral and bilateral forms of PA. PMID:27219889

  16. Recent advancements in photonic converters

    NASA Astrophysics Data System (ADS)

    Hayduk, Michael J.; Bussjager, Rebecca J.; Getbehead, Mark A.; Louthain, James A.

    2000-09-01

    Analog-to-digital converters (ADCs) are an essential component of digital receiver systems. Progress at advancing the electronic ADC modules has been very slow due in large part to the difficulties in fabricating the electronic circuitry required for very high resolution and high sampling rate converters. This slow progress has resulted in a bottleneck between the received analog signal and the digital signal processing system. Single or multiple analog signal down conversion stages are required in digital receivers to down convert the received analog signal to an intermediate frequency (IF) that can be processed by the electronic ADC. There has been much recent interest in the use of photonics for direct digitization of the analog signal at the received RF frequency thus eliminating the need for analog down conversion. This paper reviews some of the recent research advancements in photonic ADCs. We will especially focus on the development of a novel photonic ADC module that uses semiconductor saturable absorbers to perform the data quantization. We will also present recent results in the development of a mode-locked fiber laser used as the sampling source in this photonic ADC architecture.

  17. Geomagnetic observations on tristan da cunha, south atlantic ocean

    USGS Publications Warehouse

    Matzka, J.; Olsen, N.; Maule, C.F.; Pedersen, L.W.; Berarducci, A.M.; Macmillan, S.

    2009-01-01

    Few geomagnetic ground observations exist of the Earth's strongest core field anomaly, the South Atlantic Anomaly (SAA). The geomagnetic repeat station on the island Tristan da Cunha, located half-way between South Africa and South America at 37?? 05' S, 12?? 18' W, is therefore of crucial importance. We have conducted several sets of repeat station measurements during magnetically quiet conditions (Kp 2o or less) in 2004. The procedures are described and the results are compared to those from earlier campaigns and to the predictions of various global field models. Features of the local crustal bias field and the solar quiet daily variation are discussed. We also evaluate the benefit of continuous magnetic field recordings from Tristan da Cunha, and argue that such a data set is a very valuable addition to geomagnetic satellite data. Recently, funds were set up to establish and operate a magnetometer station on Tristan da Cunha during the Swarm magnetic satellite mission (2011-2014).

  18. Recent development of hydrodynamic modeling

    NASA Astrophysics Data System (ADS)

    Hirano, Tetsufumi

    2014-09-01

    In this talk, I give an overview of recent development in hydrodynamic modeling of high-energy nuclear collisions. First, I briefly discuss about current situation of hydrodynamic modeling by showing results from the integrated dynamical approach in which Monte-Carlo calculation of initial conditions, quark-gluon fluid dynamics and hadronic cascading are combined. In particular, I focus on rescattering effects of strange hadrons on final observables. Next I highlight three topics in recent development in hydrodynamic modeling. These include (1) medium response to jet propagation in di-jet asymmetric events, (2) causal hydrodynamic fluctuation and its application to Bjorken expansion and (3) chiral magnetic wave from anomalous hydrodynamic simulations. (1) Recent CMS data suggest the existence of QGP response to propagation of jets. To investigate this phenomenon, we solve hydrodynamic equations with source term which exhibits deposition of energy and momentum from jets. We find a large number of low momentum particles are emitted at large angle from jet axis. This gives a novel interpretation of the CMS data. (2) It has been claimed that a matter created even in p-p/p-A collisions may behave like a fluid. However, fluctuation effects would be important in such a small system. We formulate relativistic fluctuating hydrodynamics and apply it to Bjorken expansion. We found the final multiplicity fluctuates around the mean value even if initial condition is fixed. This effect is relatively important in peripheral A-A collisions and p-p/p-A collisions. (3) Anomalous transport of the quark-gluon fluid is predicted when extremely high magnetic field is applied. We investigate this possibility by solving anomalous hydrodynamic equations. We found the difference of the elliptic flow parameter between positive and negative particles appears due to the chiral magnetic wave. Finally, I provide some personal perspective of hydrodynamic modeling of high energy nuclear collisions

  19. Recent Results in Solar Neutrinos

    NASA Astrophysics Data System (ADS)

    Saldanha, Richard

    2011-10-01

    Solar neutrinos are an invaluable tool for studying neutrino oscillations in matter as well as probing the nuclear reactions that fuel the Sun. In this talk I will give an overview of solar neutrinos and discuss the latest results in the field. I will highlight the recent precision measurement of the ^7Be solar neutrino interaction rate with the Borexino solar neutrino detector and present the status of the analysis of pep and CNO neutrinos. I will also briefly describe future experiments and their potential to detect low energy solar neutrinos.

  20. Recent advances in understanding schizophrenia.

    PubMed

    Haller, Chiara S; Padmanabhan, Jaya L; Lizano, Paulo; Torous, John; Keshavan, Matcheri

    2014-01-01

    Schizophrenia is a highly disabling disorder whose causes remain to be better understood, and treatments have to be improved. However, several recent advances have been made in diagnosis, etiopathology, and treatment. Whereas reliability of diagnosis has improved with operational criteria, including Diagnostic and Statistical Manual of Mental Disorders, (DSM) Fifth Edition, validity of the disease boundaries remains unclear because of substantive overlaps with other psychotic disorders. Recent emphasis on dimensional approaches and translational bio-behavioral research domain criteria may eventually help move toward a neuroscience-based definition of schizophrenia. The etiology of schizophrenia is now thought to be multifactorial, with multiple small-effect and fewer large-effect susceptibility genes interacting with several environmental factors. These factors may lead to developmentally mediated alterations in neuroplasticity, manifesting in a cascade of neurotransmitter and circuit dysfunctions and impaired connectivity with an onset around early adolescence. Such etiopathological understanding has motivated a renewed search for novel pharmacological as well as psychotherapeutic targets. Addressing the core features of the illness, such as cognitive deficits and negative symptoms, and developing hypothesis-driven early interventions and preventive strategies are high-priority goals for the field. Schizophrenia is a severe, chronic mental disorder and is among the most disabling disorders in all of medicine. It is estimated by the National Institute of Mental Health (NIMH) that 2.4 million people over the age of 18 in the US suffer from schizophrenia. This illness typically begins in adolescence and derails the formative goals of school, family, and work, leading to considerable suffering and disability and reduced life expectancy by about 20 years. Treatment outcomes are variable, and some people are successfully treated and reintegrated (i.e. go back to work

  1. Summary of Recent Target Studies

    SciTech Connect

    Bieniosek, F.; O'Day, S.

    1993-02-04

    This report describes recent measurements that have been performed with the new target stack (Fig. 1). Highlights of these measurements are: (1) Pbar yields of nickel and powdered rhenium are comparable to that of copper. (2) Enhancement of pbar yield at the interface between copper and aluminum disks in the target stack has been observed. This effect occurs only when the lens is focused near the upstream edge of the target. (3) The target density depletion study in powdered rhenium showed an apparent yield reduction on the time scale of a single proton pulse, accompanied by release of airborne radioactive material.

  2. Understanding the Recent Methane Budget

    NASA Astrophysics Data System (ADS)

    Bruhwiler, L.; Dlugokencky, E. J.; Masarie, K.

    2010-12-01

    Anthropogenic sources are thought to account for roughly 2/3 of the global atmospheric methane budget, with natural sources making up the other 1/3. Emissions from wetlands are the largest contribution from natural sources while agriculture (rice and ruminants) and waste dominate anthropogenic emissions. Fugitive emissions from fossil fuel extraction are thought to make up about 20% of the global atmospheric methane budget. It is generally recognized that observed inter-annual variability in global network observations can be attributed to natural sources such as wetlands and biomass burning, while longer-term trends likely indicate changes in anthropogenic sources. Exceptions include an abrupt decrease in fossil fuel emissions in the early 1990s associated with political changes in the Former Soviet Union, and long-term trends in emissions from the Arctic due to a warming climate. The growth rate of global average atmospheric methane since the 1980s shows a steady decline until recent years when it started to increase again. Superimposed on these trends are episodes of higher growth rates. The cause of the recent increase is not currently well-understood, although climate-driven increases in wetland emissions likely played an important role, especially in the tropics. Recent increases in anthropogenic emissions, especially from rapidly expanding Asian economies cannot be ruled out. In addition, trends in the photochemical lifetime of methane must also be considered. In this paper we use both traditional data analysis of observations of methane and related species, and a state-of-the-art ensemble data assimilation system (CarbonTracker-CH4) to attribute methane variability and trends to anthropogenic and natural source processes. We pay particular attention to the Arctic, where some recent years have been the warmest on record, and to the tropics and the potential role of ENSO in driving variability of wetland emissions. Finally, we explore whether a signal in

  3. Messy genetic algorithms: Recent developments

    SciTech Connect

    Kargupta, H.

    1996-09-01

    Messy genetic algorithms define a rare class of algorithms that realize the need for detecting appropriate relations among members of the search domain in optimization. This paper reviews earlier works in messy genetic algorithms and describes some recent developments. It also describes the gene expression messy GA (GEMGA)--an {Omicron}({Lambda}{sup {kappa}}({ell}{sup 2} + {kappa})) sample complexity algorithm for the class of order-{kappa} delineable problems (problems that can be solved by considering no higher than order-{kappa} relations) of size {ell} and alphabet size {Lambda}. Experimental results are presented to demonstrate the scalability of the GEMGA.

  4. Review of recent Tevatron operations

    SciTech Connect

    Moore, R.S.; /Fermilab

    2007-06-01

    Fermilab's Tevatron proton-antiproton collider continues to improve its luminosity performance at the energy frontier {radical}s = 1.96 TeV. The recent Tevatron operation will be reviewed and notable tasks leading to advancements will be highlighted. The topics to be covered include: work performed during the 14-week shutdown in 2006, improved helical orbits, automatic orbit stabilization during high-energy physics (HEP) stores, optics corrections, improvements in the quench protection system, and avenues to maximizing the integrated luminosity delivered to the CDF and D0 experiments.

  5. Recent Progress in SERS Biosensing

    PubMed Central

    Bantz, Kyle C.; Meyer, Audrey F.; Wittenberg, Nathan J.; Im, Hyungsoon; Kurtuluş, Özge; Lee, Si Hoon; Lindquist, Nathan C.

    2011-01-01

    This perspective gives an overview of recent developments in surface-enhanced Raman scattering (SERS) for biosensing. We focus this review on SERS papers published in the last 10 years and to specific applications of detecting biological analytes. Both intrinsic and extrinsic SERS biosensing schemes have been employed to detect and identify small molecules, nucleic acids, lipids, peptides, and proteins, as well as for in vivo and cellular sensing. Current SERS substrate technologies along with a series of advancements in surface chemistry, sample preparation, intrinsic/extrinsic signal transduction schemes, and tip-enhanced Raman spectroscopy are discussed. The progress covered herein shows great promise for widespread adoption of SERS biosensing. PMID:21509385

  6. Recent novel applications of levansucrases.

    PubMed

    Li, Wenjing; Yu, Shuhuai; Zhang, Tao; Jiang, Bo; Mu, Wanmeng

    2015-09-01

    Levansucrase catalyzes three distinct reactions depending on the fructosyl acceptor molecule, including polymerization, transfructosylation, and hydrolysis. As a key biocatalyst in the synthesis of levan and levan-type fructooligosaccharides, levansucrase has been widely and intensively studied. Due to the promising physiological effects of levan and levan-type fructooligosaccharides, they exhibit great potential in food and pharmaceutical industries. Another important point that attracts much attention is the wide substrate specificity of levansucrase toward monosaccharides, disaccharides, and aromatic and alkyl alcohols, producing diverse sucrose analogues, hetero-oligosaccharides (especially lactosucrose), and interesting fructosides. The present article summarizes and discusses the recent applications of microbial levansucrase in detail. PMID:26160392

  7. Diving fatality investigations: recent changes.

    PubMed

    Edmonds, Carl; Caruso, James

    2014-06-01

    Modifications to the investigation procedures in diving fatalities have been incorporated into the data acquisition by diving accident investigators. The most germane proposal for investigators assessing diving fatalities is to delay the drawing of conclusions until all relevant diving information is known. This includes: the accumulation and integration of the pathological data; the access to dive computer information; re-enactments of diving incidents; post-mortem CT scans and the interpretation of intravascular and tissue gas detected. These are all discussed, with reference to the established literature and recent publications. PMID:24986727

  8. Recent results from the Tevatron

    SciTech Connect

    Vellidis, Costas; Bravina, L.; Foka, Y.; Kabana, S.

    2015-01-01

    The Tevatron p$\\bar{p}$ collider was shut down in 2011, after 10 years of high performance operation at a center-of-mass energy √s = 1.96 TeV in Run II. The two experiments, CDF and DZero, continue to analyze the collected data, aiming to extract all possible information regarding studies of the standard model and searches for new physics. A short review of some of the recent measurements at the Tevatron, and of the impact of the Tevatron program to high energy physics, is presented.

  9. Recent NASA Dryden COA Experience

    NASA Technical Reports Server (NTRS)

    Cobleigh, Brent

    2008-01-01

    This viewgraph presentation concerns the experience that Dryden has had with Certificate of Authorization (COA) in reference to unmanned aerial systems (UAS). It reviews recent Certificate of Authorization UAS's i.e., 2005 Altair NOAA Mission, 2006 Altair Western States Fire Mission, and 2007 Ikhana. The priorities for the safety process is reviewed, as are typical UAS hazards. Slides also review the common COA provisions, best practices and lessons learned, the 2005 NOAA/NASA Science Demonstration Flights and the use of the UAS systems during fire emergencies.

  10. Recent Progress in Quantum Hadrodynamics

    SciTech Connect

    John Dirk Walecka, Brian D. Serot

    1997-01-01

    Quantum hadrodynamics (QHD) is a framework for describing the nuclear many-body problem as a relativistic system of baryons and mesons. Motivation is given for the utility of such an approach and for the importance of basing it on a local, Lorentz-invariant lagrangian density. Calculations of nuclear matter and finite nuclei in both renormalizable and nonrenormalizable, effective QHD models are discussed. Connections are made between the effective and renormalizable models, as well as between relativistic mean-field theory and more sophisticated treatments. Recent work in QHD involving nuclear structure, electroweak interactions in nuclei, relativistic transport theory, nuclear matter under extreme conditions, and the evaluation of loop diagrams is reviewed.

  11. Recent QCD results from CDF

    SciTech Connect

    Yun, J.C.

    1990-10-10

    In this paper we report recent QCD analysis with the new data taken from CDF detector. CDF recorded an integrated luminosity of 4.4 nb{sup {minus}1} during the 1988--1989 run at center of mass system (CMS) energy of 1.8 TeV. The major topics of this report are inclusive jet, dijet, trijet and direct photon analysis. These measurements are compared of QCD predictions. For the inclusive jet an dijet analysis, tests of quark compositeness are emphasized. 11 refs., 6 figs.

  12. Recent advances in general relativity

    SciTech Connect

    Janis, A.I.; Porter, J.R.

    1992-01-01

    The papers included in this book arose from a Discussion Conference on Recent Advances in General Relativity, which was held at the University of Pittsburgh, May 3-5, 1990, in honor of Ted Newman on the occasion of his 60th birthday. The book opens with a contribution outlining successes and problems of general relativity. Two contributions are devoted to quantum gravity. Discussions are included about general relativistic astrophysics, mathematics, and gravitational radiation. There are also workshop reports on classical gravity and quantum gravity.

  13. EGF receptor ligands: recent advances

    PubMed Central

    Singh, Bhuminder; Carpenter, Graham; Coffey, Robert J.

    2016-01-01

    Seven ligands bind to and activate the mammalian epidermal growth factor (EGF) receptor (EGFR/ERBB1/HER1): EGF, transforming growth factor-alpha (TGFA), heparin-binding EGF-like growth factor (HBEGF), betacellulin (BTC), amphiregulin (AREG), epiregulin (EREG), and epigen (EPGN). Of these, EGF, TGFA, HBEGF, and BTC are thought to be high-affinity ligands, whereas AREG, EREG, and EPGN constitute low-affinity ligands. This focused review is meant to highlight recent studies related to actions of the individual EGFR ligands, the interesting biology that has been uncovered, and relevant advances related to ligand interactions with the EGFR.

  14. Recent advances in understanding schizophrenia

    PubMed Central

    Haller, Chiara S.; Padmanabhan, Jaya L.; Lizano, Paulo; Torous, John

    2014-01-01

    Schizophrenia is a highly disabling disorder whose causes remain to be better understood, and treatments have to be improved. However, several recent advances have been made in diagnosis, etiopathology, and treatment. Whereas reliability of diagnosis has improved with operational criteria, including Diagnostic and Statistical Manual of Mental Disorders, (DSM) Fifth Edition, validity of the disease boundaries remains unclear because of substantive overlaps with other psychotic disorders. Recent emphasis on dimensional approaches and translational bio-behavioral research domain criteria may eventually help move toward a neuroscience-based definition of schizophrenia. The etiology of schizophrenia is now thought to be multifactorial, with multiple small-effect and fewer large-effect susceptibility genes interacting with several environmental factors. These factors may lead to developmentally mediated alterations in neuroplasticity, manifesting in a cascade of neurotransmitter and circuit dysfunctions and impaired connectivity with an onset around early adolescence. Such etiopathological understanding has motivated a renewed search for novel pharmacological as well as psychotherapeutic targets. Addressing the core features of the illness, such as cognitive deficits and negative symptoms, and developing hypothesis-driven early interventions and preventive strategies are high-priority goals for the field. Schizophrenia is a severe, chronic mental disorder and is among the most disabling disorders in all of medicine. It is estimated by the National Institute of Mental Health (NIMH) that 2.4 million people over the age of 18 in the US suffer from schizophrenia. This illness typically begins in adolescence and derails the formative goals of school, family, and work, leading to considerable suffering and disability and reduced life expectancy by about 20 years. Treatment outcomes are variable, and some people are successfully treated and reintegrated (i.e. go back to work

  15. Recent developments of gigatron technology

    SciTech Connect

    McIntyre, P.M.; Elliott, S.M.; Gray, H.; Lee, B.; Pang, Yaoqi; Popovic, M. . Dept. of Physics; Naval Research Lab., Washington, DC; Texas A and M Univ., College Station, TX . Dept. of Physics)

    1989-01-01

    Gigatron is a new design concept for microwave power devices. A gated field-emitter array is employed as a directly modulated cathode. A ribbon beam configuration is used to mitigate space-charge effects and provide for efficient output coupling. A traveling-wave output coupler is used to obtain optimum coupling to a wide beam. Recent cathode tests are reported. Modeling of the bunched-emission process has led to an improved cathode fabrication procedure. A new application of a similar structure has led to a design for a new technology for precision tracking chambers for SSC detectors.

  16. Some Recent Results with CLAS

    SciTech Connect

    Maurik Holtrop

    2010-10-01

    The CLAS is a multipurpose, large acceptance magnetic spectrometer, instrumented with detector systems sensitive to charged and neutral particles. The experimental program at CLAS is aimed at furthering our understanding of hadronic and nuclear physics, through electron and photon scattering experiments, which cover a large range of topics, including meson and baryon spectroscopy, nucleon structure through elastic and deep inelastic scattering, nuclear transparency, nuclear correlations and nuclear structure. This talk will briefly describe the detector and the collaboration that uses it and will highlight some recent results.

  17. Recent mortality patterns in California.

    PubMed

    O'Brien, K F; Zaharia, E S

    1998-10-01

    Mortality among people with developmental disabilities was reviewed using recent data obtained from the California Department of Developmental Services. The time interval for this report was 1991-1995. We defined two study cohorts: one beginning in January 1991 and a second in April 1993. The latter period represented the years of implementation of the Coffelt settlement. Our primary interest was in the Coffelt period cohort. Statistically significant association with increased rates of mortality was found for community residence. A trend of declining mortality was noted for the community facilities from 1991-1995, but not for the developmental centers. PMID:9803127

  18. Recent CMS results on diffraction

    NASA Astrophysics Data System (ADS)

    Benoît, Roland

    2015-03-01

    Recent CMS results on diffraction are presented. These include the measurements of the soft diffractive cross sections, of the forward rapidity gap cross section, of the diffractive dijet cross section, the measurement of a large rapidity gap in W and Z boson events and the measurement of the pseudorapidity distribution of charged particles in a single diffractive enhanced sample. This last measurement is the first common result of the CMS and TOTEM collaborations. Some prospects of common CMS-TOTEM data taking are also discussed.

  19. Recent results from the Tevatron

    NASA Astrophysics Data System (ADS)

    Vellidis, Costas

    2015-05-01

    The Tevatron pp¯ collider was shut down in 2011, after 10 years of high performance operation at a center-of-mass energy √s = 1.96 TeV in Run II. The two experiments, CDF and DZero, continue to analyze the collected data, aiming to extract all possible information regarding studies of the standard model and searches for new physics. A short review of some of the recent measurements at the Tevatron, and of the impact of the Tevatron program to high energy physics, is presented.

  20. Implications of recent multimodel attribution studies for climate sensitivity

    NASA Astrophysics Data System (ADS)

    Lewis, Nicholas

    2016-03-01

    Equilibrium climate sensitivity (ECS) is inferred from estimates of instrumental-period warming attributable solely to greenhouse gases (AW), as derived in two recent multi-model detection and attribution (D&A) studies that apply optimal fingerprint methods with high spatial resolution to 3D global climate model simulations. This approach minimises the key uncertainty regarding aerosol forcing without relying on low-dimensional models. The "observed" AW distributions from the D&A studies together with an observationally-based estimate of effective planetary heat capacity (EHC) are applied as observational constraints in (AW, EHC) space. By varying two key parameters—ECS and effective ocean diffusivity—in an energy balance model forced solely by greenhouse gases, an invertible map from the bivariate model parameter space to (AW, EHC) space is generated. Inversion of the constrained (AW, EHC) space through a transformation of variables allows unique recovery of the observationally-constrained joint distribution for the two model parameters, from which the marginal distribution of ECS can readily be derived. The method is extended to provide estimated distributions for transient climate response (TCR). The AW distributions from the two D&A studies produce almost identical results. Combining the two sets of results provides best estimates (5-95 % ranges) of 1.66 (0.7-3.2) K for ECS and 1.37 (0.65-2.2) K for TCR, in line with those from several recent studies based on observed warming from all causes but with tighter uncertainty ranges than for some of those studies. Almost identical results are obtained from application of an alternative profile likelihood statistical methodology.

  1. [Recent trend in subacute meningitides].

    PubMed

    Kamei, Satoshi

    2012-01-01

    Recent clinical management of subacute meningitis is reviewed. Tuberculous meningitis (TbM) and fungal meningitis are the commonest cause of subacute meningitis. Since the delayed treatment in these meningitides is strongly associated with poor outcome, these clinical managements are required to be neurological emergency. Recent clinical guidelines of these meningitides recommended new therapeutic managements. Treatment for TbM should consist of 4 drugs (isoniazid, rifampicin, pyrazinamide, ethambutol) for 2 months followed by 2 drugs (isoniazid, rifampicin) for at least 10 months. Adjunctive corticosteroids should be given to all non-HIV patients with TbM, regardless of disease severity. Treatment for CNS Cryptococcosis and Candidiasis with non-HIV infected and non-transplant hosts is lipid formulation of Amphotericin B combined with flucytosine for at least 4 weeks for induction therapy. This 4-week induction therapy is reserved for patients with meningoencephalitis without neurological complications and CSF yeast culture results that are negative after 2 weeks of treatment. Then, the consolidation with fluconazole for 8 weeks is started. Voriconazole is recommended for the primary treatment of CNS Aspergillosis including meningitis. If the diagnosis is made early, if clinicians adhere to the basic principles of these guidelines, and if the underlying disease is controlled, these meningitides could be managed successfully in the most of patients. PMID:23196452

  2. Recent advance in patient monitoring

    PubMed Central

    2010-01-01

    Recent advance in technology has developed a lot of new aspects of clinical monitoring. We can monitor sedation levels during anesthesia using various electroencephalographic (EEG) indices, while it is still not useful for anesthesia depth monitoring. Some attempts are made to monitor the changes in sympathetic nerve activity as one of the indicators of stress, pain/analgesia, or anesthesia. To know the balance of sympathetic and parasympathetic activity, heart rate or blood pressure variability is investigated. For trend of cardiac output, low invasive monitors have been investigated. Improvement of ultrasound enables us to see cardiac structure and function continuously and clearer, increases success rate and decreases complication of central venous puncture and various kinds of nerve blocks. Without inserting an arterial catheter, trends of arterial oxygen tension or carbon dioxide tension can be monitored. Indirect visualization of the airway decreases difficult intubation and makes it easier to teach tracheal intubation. The changes in blood volume can be speculated non-invasively. Cerebral perfusion and metabolism are not ordinary monitored yet, but some studies show their usefulness in management of critically ill. This review introduces recent advances in various monitors used in anesthesia and critical care including some studies of the author, especially focused on EEG and cardiac output. However, the most important is that these new monitors are not almighty but should be used adequately in a limited situation where their meaning is confirmed. PMID:20877698

  3. [Recent advances in transmissible tumors].

    PubMed

    Tingting, Yin; Lu, Wang; Guodong, Wang

    2015-11-01

    Transmissible tumors are a class of tumor that can be transmitted between individuals through living cells. So far, four types of transmissible tumors including canine transmissible venereal tumor (CTVT),Tasmanian devil facial tumor disease (DFTD), soft-shell clams leukemia (SSCL), and hamsters reticulum cell sarcoma (HRCS)have been discovered and identified. In the last decades, these transmissible tumors have been proved to be transmitted through living cells by cytological, histological and genetic studies. CTVT, the oldest mammalian somatic cell line, and DFTD originated from Schwann cell have been reported to avoid immunological recognition by down-regulating MHC expression, while a high copy number of Steamer retrotransposon is commonly exist in SSCL. In recent years, the whole-genome sequencing of CTVT and DFTD have been completed which facilitates studies on the mechanisms of tumorigenesis, transmission and evolution of transmissible tumors at the whole-genome level. In this review, we summarize the recent advances in transmissible tumors and discuss the research focus in next decade. PMID:26582522

  4. Recent advances in understanding dengue

    PubMed Central

    Yacoub, Sophie; Mongkolsapaya, Juthathip; Screaton, Gavin

    2016-01-01

    Dengue is an emerging threat to billions of people worldwide. In the last 20 years, the incidence has increased four-fold and this trend appears to be continuing. Caused by one of four viral serotypes, dengue can present as a wide range of clinical phenotypes with the severe end of the spectrum being defined by a syndrome of capillary leak, coagulopathy, and organ impairment. The pathogenesis of severe disease is thought to be in part immune mediated, but the exact mechanisms remain to be defined. The current treatment of dengue relies on supportive measures with no licensed therapeutics available to date. There have been recent advances in our understanding of a number of areas of dengue research, of which the following will be discussed in this review: the drivers behind the global dengue pandemic, viral structure and epitope binding, risk factors for severe disease and its pathogenesis, as well as the findings of recent clinical trials including therapeutics and vaccines. We conclude with current and future dengue control measures and key areas for future research. PMID:26918159

  5. Recent developments in SQUID NDE

    NASA Astrophysics Data System (ADS)

    Krause, H.-J.; Kreutzbruck, M. v.

    2002-03-01

    By presenting brief summaries of recent application highlights, an overview of NDE methods using SQUIDs is given. Bridge inspection with a SQUID array integrated with a yoke magnet excitation was shown by scanning along the pre-stressed steel of bridges and verified by opening the bridge deck. As the construction of the megaliner Airbus aircraft progresses, testing procedures for extremely thick-walled structures are needed. Defects at a depth of up to 40 mm were measured in a bolted three-layer aluminum sample with a total thickness of 62 mm. For the investigation of aircraft wheels, a remote eddy current (EC) excitation scheme yields better depth selectivity. Defects with an inside penetration of only 10% could be detected. SQUID magnetometers are well suited for pulsed EC techniques which cover a broader depth range than standard single frequency EC. An inversion procedure is presented providing a tomographic-like conductivity image of stacked aluminum samples. A recent SQUID application is nondestructive testing of niobium sheets used for superconducting cavities of particle accelerators. The detection of tantalum inclusions and other impurities which lower the cavity performance is based on the measurement of local current inhomogeneities caused by EC excitation or thermal gradients. Alternate techniques using SQUID sensors, such as modulated excitation arrays, rotating field schemes, sensor multiplexing, magnetic moment detection, and microscopy setups, are discussed.

  6. Recent advances in migraine therapy.

    PubMed

    Antonaci, Fabio; Ghiotto, Natascia; Wu, Shizheng; Pucci, Ennio; Costa, Alfredo

    2016-01-01

    Migraine is a common and highly disabling neurological disorder associated with a high socioeconomic burden. Effective migraine management depends on adequate patient education: to avoid unrealistic expectations, the condition must be carefully explained to the patient soon as it is diagnosed. The range of available acute treatments has increased over time. At present, abortive migraine therapy can be classed as specific (ergot derivatives and triptans) or non-specific (analgesics and non-steroidal anti-inflammatory drugs). Even though acute symptomatic therapy can be optimised, migraine continues to be a chronic and potentially progressive condition. In addition to the drugs officially approved for migraine prevention by international governmental regulatory agencies, numerous different agents are commonly used for this indication, showing various levels of evidence of efficacy and tolerability. Guidelines published in recent years, based on evidence-based medicine data on migraine prophylaxis, are a useful source of guidance, especially for primary care physicians and neurologists without specific expertise in headache medicine. Although the field of pharmacological migraine prevention has seen few advances in recent years, potential novel approaches are now being developed. This review looks at emerging pharmacological strategies for acute and preventive migraine treatment that are nearing or have already entered the clinical trial phase. Specifically, it discusses preclinical and clinical data on compounds acting on calcitonin gene-related peptide or its receptor, the serotonin 5-HT1F receptor, nitric oxide synthase, and acid-sensing ion channel blockers. PMID:27330903

  7. Recent work on bipolar nebulae

    NASA Technical Reports Server (NTRS)

    Cohen, M.

    1983-01-01

    The results of recent studies of bipolar nebulae (BPN) using nebular-polarization mapping, spectropolarimetry, near-IR spectroscopy, far-IR photometry, and radio-maser and continuum observations are surveyed. The characteristics of several BPN of different evolutionary types are discussed and illustrated with spectra, model drawings, and maps. As shown in a Hertzsprung-Russell diagram of 19 BPN, this morphological class includes pre-main-sequence stars, red giants in transition to ordinary planetary nebulae, pre-white-dwarfs, a dust-shrouded carbon star, and a visual binary with a type-O primary. VLA 6-cm observations of the latter object, MWC 349, reveal a morphology similar to the optical structure of the Red Rectangle illuminated by HD 44179: it is suggested that equatorial dusty tori may occur commonly at different phases of stellar evolution, and hence that BPN may be relatively abundant, although short-lived, phenomena.

  8. Recent Trends in Nucleotide Synthesis.

    PubMed

    Roy, Béatrice; Depaix, Anaïs; Périgaud, Christian; Peyrottes, Suzanne

    2016-07-27

    Focusing on the recent literature (since 2000), this review outlines the main synthetic approaches for the preparation of 5'-mono-, 5'-di-, and 5'-triphosphorylated nucleosides, also known as nucleotides, as well as several derivatives, namely, cyclic nucleotides and dinucleotides, dinucleoside 5',5'-polyphosphates, sugar nucleotides, and nucleolipids. Endogenous nucleotides and their analogues can be obtained enzymatically, which is often restricted to natural substrates, or chemically. In chemical synthesis, protected or unprotected nucleosides can be used as the starting material, depending on the nature of the reagents selected from P(III) or P(V) species. Both solution-phase and solid-support syntheses have been developed and are reported here. Although a considerable amount of research has been conducted in this field, further work is required because chemists are still faced with the challenge of developing a universal methodology that is compatible with a large variety of nucleoside analogues. PMID:27319940

  9. Recent advances in cohesin biology.

    PubMed

    Rankin, Susannah; Dawson, Dean S

    2016-01-01

    Sister chromatids are tethered together from the time they are formed in S-phase until they separate at anaphase. A protein complex called cohesin is responsible for holding the sister chromatids together and serves important roles in chromosome condensation, gene regulation, and the repair of DNA damage. Cohesin contains an open central pore and becomes topologically engaged with its DNA substrates. Entrapped DNA can be released either by the opening of a gate in the cohesin ring or by proteolytic cleavage of a component of the ring. This review summarizes recent research that provides important new insights into how DNA enters and exits the cohesin ring and how the rings behave on entrapped DNA molecules to provide functional cohesion. PMID:27547382

  10. Recent Advances in Diverticular Disease.

    PubMed

    Peery, Anne F

    2016-07-01

    Diverticular disease is common and accounts for substantial health care utilization in the USA. Recent publications in the areas of diverticulosis and diverticular disease have highlighted several notable advances that are now changing practice. Despite colonic diverticula being common, only 1-4 % of individuals with colonic diverticula will develop diverticulitis. After a first occurrence of acute diverticulitis, the risk of recurrence is 20 % at 5 years. Complications most commonly occur with the first occurrence of acute diverticulitis and not with recurrent episodes. After an episode of diverticulitis, many patients continue to experience chronic gastrointestinal symptoms. Prophylactic surgery is an option to reduce the risk of recurrence and its negative impact on quality of life. Importantly, the rationale for surgery is no longer to prevent complications because this risk is low. The review concludes with practical recommendations for patients with diverticulosis and diverticular disease. PMID:27241190

  11. Recent progress in henipavirus research.

    PubMed

    Halpin, Kim; Mungall, Bruce A

    2007-09-01

    Following the discovery of two new paramyxoviruses in the 1990s, much effort has been placed on rapidly finding the reservoir hosts, characterising the genomes, identifying the viral receptors and formulating potential vaccines and therapeutic options for these viruses, Hendra and Nipah viruses caused zoonotic disease on a scale not seen before with other paramyxoviruses. Nipah virus particularly caused high morbidity and mortality in humans and high morbidity in pig populations in the first outbreak in Malaysia. Both viruses continue to pose a threat with sporadic outbreaks continuing into the 21st century. Experimental and surveillance studies identified that pteropus bats are the reservoir hosts. Research continues in an attempt to understand events that precipitated spillover of these viruses. Discovered on the cusp of the molecular technology revolution, much progress has been made in understanding these new viruses. This review endeavours to capture the depth and breadth of these recent advances. PMID:17629946

  12. Recent Advances in Superhard Materials

    NASA Astrophysics Data System (ADS)

    Zhao, Zhisheng; Xu, Bo; Tian, Yongjun

    2016-07-01

    In superhard materials research, two topics are of central focus. One is to understand hardness microscopically and to establish hardness models with atomic parameters, which can be used to guide the design or prediction of novel superhard crystals. The other is to synthesize superhard materials with enhanced comprehensive performance (i.e., hardness, fracture toughness, and thermal stability), with the ambition of achieving materials harder than natural diamond. In this review, we present recent developments in both areas. The microscopic hardness models of covalent single crystals are introduced and further generalized to polycrystalline materials. Current research progress in novel superhard materials and nanostructuring approaches for high-performance superhard materials are discussed. We also clarify a long-standing controversy about the criterion for performing a reliable indentation hardness measurement.

  13. Recent results from telescope array

    NASA Astrophysics Data System (ADS)

    Fukushima, Masaki

    2015-08-01

    The Telescope Array (TA) is an experiment to observe Ultra-High Energy Cosmic Rays (UHECRs). TA's recent results, the energy spectrum and anisotropy based on the 6-year surface array data, and the primary composition obtained from the shower maximum (XMAX) are reported. The spectrum demonstrates a clear dip and cutoff. The shape of the spectrum is well described by the energy loss of extra-galactic protons interacting with the cosmic microwave background (CMB). Above the cutoff, a medium-scale (20∘ radius) flux enhancement was observed near the Ursa-Major. A chance probability of creating this hotspot from the isotropic flux is 4.0 σ. The measured ⟨XMAX⟩ is consistent with the primary being proton or light nuclei for energies 1018.2 eV-1019.2 eV.

  14. Recent advances in mycotoxins detection.

    PubMed

    Chauhan, Ruchika; Singh, Jay; Sachdev, Tushar; Basu, T; Malhotra, B D

    2016-07-15

    Mycotoxins contamination in both food and feed is inevitable. Mycotoxin toxicity in foodstuff can occur at very low concentrations necessitating early availability of sensitive and reliable methods for their detection. The present research thrust is towards the development of a user friendly biosensor for mycotoxin detection at both academic and industrial levels to replace conventional expensive chromatographic and ELISA techniques. This review critically analyzes the recent research trend towards the construction of immunosensor, aptasensor, enzymatic sensors and others for mycotoxin detection with a reference to label and label free methods, synthesis of new materials including nano dimension, and transuding techniques. Technological aspects in the development of biosensors for mycotoxin detection, current challenges and future prospects are also included to provide a overview and suggestions for future research directions. PMID:27019032

  15. Recent advances in cohesin biology

    PubMed Central

    2016-01-01

    Sister chromatids are tethered together from the time they are formed in S-phase until they separate at anaphase. A protein complex called cohesin is responsible for holding the sister chromatids together and serves important roles in chromosome condensation, gene regulation, and the repair of DNA damage. Cohesin contains an open central pore and becomes topologically engaged with its DNA substrates. Entrapped DNA can be released either by the opening of a gate in the cohesin ring or by proteolytic cleavage of a component of the ring. This review summarizes recent research that provides important new insights into how DNA enters and exits the cohesin ring and how the rings behave on entrapped DNA molecules to provide functional cohesion. PMID:27547382

  16. Recent advances in synthetic biosafety

    PubMed Central

    Simon, Anna J.; Ellington, Andrew D.

    2016-01-01

    Synthetically engineered organisms hold promise for a broad range of medical, environmental, and industrial applications. Organisms can potentially be designed, for example, for the inexpensive and environmentally benign synthesis of pharmaceuticals and industrial chemicals, for the cleanup of environmental pollutants, and potentially even for biomedical applications such as the targeting of specific diseases or tissues. However, the use of synthetically engineered organisms comes with several reasonable safety concerns, one of which is that the organisms or their genes could escape their intended habitats and cause environmental disruption. Here we review key recent developments in this emerging field of synthetic biocontainment and discuss further developments that might be necessary for the widespread use of synthetic organisms. Specifically, we discuss the history and modern development of three strategies for the containment of synthetic microbes: addiction to an exogenously supplied ligand; self-killing outside of a designated environment; and self-destroying encoded DNA circuitry outside of a designated environment.

  17. Recent Advances in Contextuality Tests

    NASA Astrophysics Data System (ADS)

    Thompson, Jayne; Kurzyński, Paweł; Lee, Su-Yong; Soeda, Akihito; Kaszlikowski, Dagomir

    2016-07-01

    Our everyday experiences support the hypothesis that physical systems exist independently of the act of observation. Concordant theories are characterized by the objective realism assumption whereby the act of measurement simply reveals preexisting well-defined elements of reality. In stark contrast quantum mechanics portrays a world in which reality loses its objectivity and is in fact created by observation. Quantum contextuality as first discovered by Bell [1] and Kochen-Specker [2] captures aspects of this philosophical clash between classical and quantum descriptions of the world. Here we briefly summarize some of the more recent advances in the field of quantum contextuality. We approach quantum contextuality through its close relation to Bell type nonlocal scenarios and highlight some of the rapidly developing tests and experimental implementations.

  18. Recent Advances in Singlet Fission

    NASA Astrophysics Data System (ADS)

    Smith, Millicent B.; Michl, Josef

    2013-04-01

    A survey is provided of recent progress in the understanding of singlet fission, a spin-allowed process in which a singlet excited molecule shares its energy with a ground-state neighbor to produce two triplet excited molecules. It has been observed to occur in single-crystal, polycrystalline, and amorphous solids, on timescales from 80 fs to 25 ps, producing triplet yields as high as 200%. Photovoltaic devices using the effect have shown external quantum efficiencies in excess of 100%. Almost all the efficient materials are alternant hydrocarbons of the acene series or their simple derivatives, and it is argued that a wider structural variety would be desirable. The current state of the development of molecular structure design rules, based on first-principles theoretical considerations, is described along with initial examples of implementation.

  19. Recent advances in Chinese palaeontology.

    PubMed

    Xu, Xing; Luo, Zhe-Xi; Rong, Jia-Yu

    2010-01-22

    Discoveries are a driving force for progress in palaeontology. Palaeontology as a discipline of scientific inquiry has gained many fresh insights into the history of life, from the discoveries of many new fossils in China in the last 20 years, and from the new ideas derived from these fossils. This special issue of Proceedings of Royal Society B entitled Recent Advances in Chinese Palaeontology selects some of the very latest studies aimed at resolving the current problems of palaeontology and evolutionary biology based on new fossils from China. These fossils and their studies help to clarify some historical debates about a particular fossil group, or to raise new questions about history of life, or to pose a new challenge in our pursuit of science. These works on new Chinese fossils have covered the whole range of the diversity through the entire Phanerozoic fossil record. PMID:19812080

  20. Recent research in snow hydrology

    NASA Technical Reports Server (NTRS)

    Dozier, Jeff

    1987-01-01

    Recent work on snow-pack energy exchange has involved detailed investigations on snow albedo and attempts to integrate energy-balance calculations over drainage basins. Along with a better understanding of the EM properties of snow, research in remote sensing has become more focused toward estimation of snow-pack properties. In snow metamorphism, analyses of the physical processes must now be coupled to better descriptions of the geometry of the snow microstructure. The dilution method now appears to be the best direct technique for measuring the liquid water content of snow; work on EM methods continues. Increasing attention to the chemistry of the snow pack has come with the general focus on acid precipitation in hydrology.

  1. Leukocyte rheology in recent stroke.

    PubMed

    Ernst, E; Matrai, A; Paulsen, F

    1987-01-01

    Eighteen patients with recent ischemic stroke were compared with an equal number of matched controls. Standardized suspensions of red cells as well as of red and white cells were filtered in a new filtration apparatus capable of discriminating between cell deformability and filter occlusion. Results show that red cell deformability, although slightly lower than in controls, is not significantly altered in stroke patients. Filter occlusion, however, was significantly higher in patients when red and white cell suspensions were filtered, but not when red cell suspensions were used, suggesting that white cell filterability is impaired after stroke, which could be due to decreased deformability and/or increased adhesiveness of leukocytes. Slowed white cell passage may also occur in the living microcirculation and may present an obstacle to nutritive flow in exchange vessels, possibly contributing to local ischemia and tissue necrosis after stroke. PMID:3810770

  2. Recent advances in coronal heating.

    PubMed

    De Moortel, Ineke; Browning, Philippa

    2015-05-28

    The solar corona, the tenuous outer atmosphere of the Sun, is orders of magnitude hotter than the solar surface. This 'coronal heating problem' requires the identification of a heat source to balance losses due to thermal conduction, radiation and (in some locations) convection. The review papers in this Theo Murphy meeting issue present an overview of recent observational findings, large- and small-scale numerical modelling of physical processes occurring in the solar atmosphere and other aspects which may affect our understanding of the proposed heating mechanisms. At the same time, they also set out the directions and challenges which must be tackled by future research. In this brief introduction, we summarize some of the issues and themes which reoccur throughout this issue. PMID:25897095

  3. Recent advances in computational aerodynamics

    NASA Astrophysics Data System (ADS)

    Agarwal, Ramesh K.; Desse, Jerry E.

    1991-04-01

    The current state of the art in computational aerodynamics is described. Recent advances in the discretization of surface geometry, grid generation, and flow simulation algorithms have led to flowfield predictions for increasingly complex and realistic configurations. As a result, computational aerodynamics is emerging as a crucial enabling technology for the development and design of flight vehicles. Examples illustrating the current capability for the prediction of aircraft, launch vehicle and helicopter flowfields are presented. Unfortunately, accurate modeling of turbulence remains a major difficulty in the analysis of viscosity-dominated flows. In the future inverse design methods, multidisciplinary design optimization methods, artificial intelligence technology and massively parallel computer technology will be incorporated into computational aerodynamics, opening up greater opportunities for improved product design at substantially reduced costs.

  4. Recent trends in extractive metallurgy

    NASA Astrophysics Data System (ADS)

    Bell, Peter M.

    Metallurgists and solution geochemists are joining forces to develop processes for extraction of metals from low-grade ores. The processes, which come under the name hydrometallurgy, include several new applications of solvent extraction techniques. Aqueous solutions are employed, leaching metals from ores, mine waste dumps, and even from deposits still in the ground. It was notable, for example, that Chemical and Engineering News (Feb. 8, 1982) recently featured the subject of hydrometallurgy in a special report. They noted that ‘recovering metals by use of aqueous solutions at relatively low temperatures increasingly is competing with dry, high-temperature pyrometallurgical methods.’ The relatively new techniques have caused a revolution, of sorts, in engineering programs of university metallurgy departments. The challenge of developing selective metal dissolution processes is drawing upon the best national talent in the fields of solution geochemistry and metallurgy.

  5. Recent results from SND detector

    NASA Astrophysics Data System (ADS)

    Achasov, M. N.; Barnyakov, A. Yu.; Beloborodov, K. I.; Berdyugin, A. V.; Bogdanchikov, A. G.; Botov, A. A.; Dimova, T. V.; Druzhinin, V. P.; Golubev, V. B.; Kardapoltsev, L. V.; Kharlamov, A. G.; Koop, I. A.; Korol, A. A.; Koshuba, S. V.; Kovrizhin, D. P.; Kupich, A. S.; Martin, K. A.; Obrazovsky, A. E.; Pakhtusova, E. V.; Rogozina, E. V.; Serednyakov, S. I.; Shatunov, Yu. M.; Shtol, D. A.; Silagadze, Z. K.; Surin, I. K.; Usov, Yu. V.; Vasiljev, A. V.

    2016-05-01

    Recent results from the SND detector obtained in experiments at the VEPP-2000 e+e- collider are presented. The reactions e+e- → ηπ+π-, e+e- → K+K-, e+e- → π+π-π0, e+e- → ωπ0, e+e- → ωη have been studied in the energy region 1.05-2.00 GeV. The neutron and proton electromagnetic form factors have been measured in the energy range from the threshold up to 2 GeV. The result of the search of the rare process e+e- → η' is also presented.

  6. Recent advances in coronal heating

    PubMed Central

    De Moortel, Ineke; Browning, Philippa

    2015-01-01

    The solar corona, the tenuous outer atmosphere of the Sun, is orders of magnitude hotter than the solar surface. This ‘coronal heating problem’ requires the identification of a heat source to balance losses due to thermal conduction, radiation and (in some locations) convection. The review papers in this Theo Murphy meeting issue present an overview of recent observational findings, large- and small-scale numerical modelling of physical processes occurring in the solar atmosphere and other aspects which may affect our understanding of the proposed heating mechanisms. At the same time, they also set out the directions and challenges which must be tackled by future research. In this brief introduction, we summarize some of the issues and themes which reoccur throughout this issue. PMID:25897095

  7. Recent Studies of Runway Roughness

    NASA Technical Reports Server (NTRS)

    Morris, Garland; Hall, Albert W.

    1965-01-01

    Recent studies of NASA research related to aircraft operating problems on rough runways are presented. Some of these investigations were conducted cooperatively with the airport operators, with the Federal Aviation Agency, and with the U.S. Air Force. The studies show that criteria based on power spectral levels of runway-profile data are not sufficient to define acceptable levels of runway roughness from the piloting viewpoint. Because of the large variation in response characteristics between various types of aircraft, a runway may be acceptable for some aircraft and unacceptable for others. A criterion for roughness, therefore, should be expressed in terms of aircraft response - preferably, cockpit acceleration. A criterion suggested is that the maximum vertical acceleration in the cockpit should not exceed +/- 0.4 g for sections of the runway where precise aircraft control is required.

  8. Recent Advances in Epidural Analgesia

    PubMed Central

    Bauer, Maria; George, John E.; Seif, John; Farag, Ehab

    2012-01-01

    Neuraxial anesthesia is a term that denotes all forms of central blocks, involving the spinal, epidural, and caudal spaces. Epidural anesthesia is a versatile technique widely used in anesthetic practice. Its potential to decrease postoperative morbidity and mortality has been demonstrated by numerous studies. To maximize its perioperative benefits while minimizing potential adverse outcomes, the knowledge of factors affecting successful block placement is essential. This paper will provide an overview of the pertinent anatomical, pharmacological, immunological, and technical aspects of epidural anesthesia in both adult and pediatric populations and will discuss the recent advances, the related rare but potentially devastating complications, and the current recommendations for the use of anticoagulants in the setting of neuraxial block placement. PMID:22174708

  9. Epigenesis in Kant: Recent reconsiderations.

    PubMed

    Zammito, John H

    2016-08-01

    Epigenesis has become a far more exciting issue in Kant studies recently, especially with the publication of Jennifer Mensch's Kant' Organicism. In my commentary, I propose to clarify my own position on epigenesis relative to that of Mensch and others by once again considering the discourse of epigenesis in the wider eighteenth century. Historically, I maintain that Kant was never fully an epigenesist because he feared its materialist implications. This makes it highly unlikely that he drew heavily, as other interpreters like Dupont and Huneman have suggested, on Caspar Friedrich Wolff for his ultimate theory of "generic preformation." In order to situate more precisely what Kant made of epigenesis, I distinguish his metaphysical use, as elaborated by Mensch, from his view of it as a theory for life science. In that light, I raise questions about the scope and authority of philosophy vis a vis natural science. PMID:27474189

  10. Recent advances in medical ultrasound

    NASA Astrophysics Data System (ADS)

    Crum, Lawrence

    2014-03-01

    Ultrasound has become one of the most widely used imaging modalities in medicine; yet, before ultrasound-imaging systems became available, high intensity ultrasound was used as early as the 1950s to ablate regions in the brains of human patients. Recently, a variety of novel applications of ultrasound have been developed that include site-specific and ultrasound-mediated drug delivery, acoustocautery, lipoplasty, histotripsy, tissue regeneration, and bloodless surgery, among many others. This lecture will review several new applications of therapeutic ultrasound and address some of the basic scientific questions and future challenges in developing these methods and technologies for general use in our society. We shall particularly emphasize the use of High Intensity Focused Ultrasound (HIFU) in the treatment of benign and malignant tumors.

  11. Recent Inland Water Temperature Trends

    NASA Astrophysics Data System (ADS)

    Hook, Simon; Healey, Nathan; Lenters, John; O'Reilly, Catherine

    2016-04-01

    We are using thermal infrared satellite data in conjunction with in situ measurements to produce water temperatures for all the large inland water bodies in North America and the rest of the world for potential use as climate indicator. Recent studies have revealed significant warming of inland waters throughout the world. The observed rate of warming is - in many cases - greater than that of the ambient air temperature. These rapid, unprecedented changes in inland water temperatures have profound implications for lake hydrodynamics, productivity, and biotic communities. Scientists are just beginning to understand the global extent, regional patterns, physical mechanisms, and ecological consequences of lake warming. As part of our work we have collected thermal infrared satellite data from those satellite sensors that provide long-term and frequent spaceborne thermal infrared measurements of inland waters including ATSR, AVHRR, and MODIS and used these to examine trends in water surface temperature for approximately 169 of the largest inland water bodies in the world. We are now extending this work to generate temperature time-series of all North American inland water bodies that are sufficiently large to be studied using 1km resolution satellite data for the last 3 decades, approximately 268 lakes. These data are then being related to changes in the surface air temperature and compared with regional trends in water surface temperature derived from CMIP5/IPCC model simulations/projections to better predict future temperature changes. We will discuss the available datasets and processing methodologies together with the patterns they reveal based on recent changes in the global warming, with a particular focus on the inland waters of the southwestern USA.

  12. Recent deformation rates on Venus

    NASA Astrophysics Data System (ADS)

    Grimm, Robert E.

    1994-11-01

    Constraints on the recent geological evolution of Venus may be provided by quantitative estimates of the rates of the principal resurfacing processes, volcanism and tectonism. This paper focuses on the latter, using impact craters as strain indicators. The total postimpact tectonic strain lies in the range 0.5-6.5%, which defines a recent mean strain rate of 10-18-10-17/s when divided by the mean surface age. Interpretation of the cratering record as one of pure production requires a decline in resurfacing rates at about 500 Ma (catastrophic resurfacing model). If distributed tectonic resurfacing contributed strongly before that time, as suggested by the widespread occurrence of tessera as inliers, the mean global strain rate must have been at least approximately 10-15/s, which is also typical of terrestrial active margins. Numerical calculations of the response of the lithosphere to inferred mantle convective forces were performed to test the hypothesis that a decrease in surface strain rate by at least two orders of magnitude could be caused by a steady decline in heat flow over the last billion years. Parameterized convection models predict that the mean global thermal gradient decreases by only about 5 K/km over this time; even with the exponential dependence of viscosity upon temperature, the surface strain rate drops by little more than one order of magnitude. Strongly unsteady cooling and very low thermal gradients today are necessary to satisfy the catastrophic model. An alternative, uniformitarian resurfacing hypothesis holds that Venus is resurfaced in quasi-random 'patches' several hundred kilometers in size that occur in response to changing mantle convection patterns.

  13. Mars Recent Climate Change Workshop

    NASA Astrophysics Data System (ADS)

    Haberle, Robert M.; Owen, Sandra J.

    2012-11-01

    Mars Recent Climate Change Workshop NASA/Ames Research Center May 15-17, 2012 Climate change on Mars has been a subject of great interest to planetary scientists since the 1970's when orbiting spacecraft first discovered fluvial landforms on its ancient surfaces and layered terrains in its polar regions. By far most of the attention has been directed toward understanding how "Early Mars" (i.e., Mars >~3.5 Gya) could have produced environmental conditions favorable for the flow of liquid water on its surface. Unfortunately, in spite of the considerable body of work performed on this subject, no clear consensus has emerged on the nature of the early Martian climate system because of the difficulty in distinguishing between competing ideas given the ambiguities in the available geological, mineralogical, and isotopic records. For several reasons, however, the situation is more tractable for "Recent Mars" (i.e., Mars during past 20 My or so). First, the geologic record is better preserved and evidence for climate change on this time scale has been building since the rejuvenation of the Mars Exploration Program in the late 1990's. The increasing coverage of the planet from orbit and the surface, coupled with accurate measurements of surface topography, increasing spatial resolution of imaging cameras, improved spectral resolution of infrared sensors, and the ability to probe the subsurface with radar, gamma rays, and neutron spectroscopy, has not only improved the characterization of previously known climate features such as polar layered terrains and glacier-related landforms, but has also revealed the existence of many new features related to recent climate change such as polygons, gullies, concentric crater fill, and a latitude dependent mantle. Second, the likely cause of climate change - spin axis/orbital variations - is more pronounced on Mars compared to Earth. Spin axis/orbital variations alter the seasonal and latitudinal distribution of sunlight, which can

  14. RECENT ADVANCES IN QUANTITATIVE NEUROPROTEOMICS

    PubMed Central

    Craft, George E; Chen, Anshu; Nairn, Angus C

    2014-01-01

    The field of proteomics is undergoing rapid development in a number of different areas including improvements in mass spectrometric platforms, peptide identification algorithms and bioinformatics. In particular, new and/or improved approaches have established robust methods that not only allow for in-depth and accurate peptide and protein identification and modification, but also allow for sensitive measurement of relative or absolute quantitation. These methods are beginning to be applied to the area of neuroproteomics, but the central nervous system poses many specific challenges in terms of quantitative proteomics, given the large number of different neuronal cell types that are intermixed and that exhibit distinct patterns of gene and protein expression. This review highlights the recent advances that have been made in quantitative neuroproteomics, with a focus on work published over the last five years that applies emerging methods to normal brain function as well as to various neuropsychiatric disorders including schizophrenia and drug addiction as well as of neurodegenerative diseases including Parkinson’s disease and Alzheimer’s disease. While older methods such as two-dimensional polyacrylamide electrophoresis continued to be used, a variety of more in-depth MS-based approaches including both label (ICAT, iTRAQ, TMT, SILAC, SILAM), label-free (label-free, MRM, SWATH) and absolute quantification methods, are rapidly being applied to neurobiological investigations of normal and diseased brain tissue as well as of cerebrospinal fluid (CSF). While the biological implications of many of these studies remain to be clearly established, that there is a clear need for standardization of experimental design and data analysis, and that the analysis of protein changes in specific neuronal cell types in the central nervous system remains a serious challenge, it appears that the quality and depth of the more recent quantitative proteomics studies is beginning to

  15. Recent advances in quantitative neuroproteomics.

    PubMed

    Craft, George E; Chen, Anshu; Nairn, Angus C

    2013-06-15

    The field of proteomics is undergoing rapid development in a number of different areas including improvements in mass spectrometric platforms, peptide identification algorithms and bioinformatics. In particular, new and/or improved approaches have established robust methods that not only allow for in-depth and accurate peptide and protein identification and modification, but also allow for sensitive measurement of relative or absolute quantitation. These methods are beginning to be applied to the area of neuroproteomics, but the central nervous system poses many specific challenges in terms of quantitative proteomics, given the large number of different neuronal cell types that are intermixed and that exhibit distinct patterns of gene and protein expression. This review highlights the recent advances that have been made in quantitative neuroproteomics, with a focus on work published over the last five years that applies emerging methods to normal brain function as well as to various neuropsychiatric disorders including schizophrenia and drug addiction as well as of neurodegenerative diseases including Parkinson's disease and Alzheimer's disease. While older methods such as two-dimensional polyacrylamide electrophoresis continued to be used, a variety of more in-depth MS-based approaches including both label (ICAT, iTRAQ, TMT, SILAC, SILAM), label-free (label-free, MRM, SWATH) and absolute quantification methods, are rapidly being applied to neurobiological investigations of normal and diseased brain tissue as well as of cerebrospinal fluid (CSF). While the biological implications of many of these studies remain to be clearly established, that there is a clear need for standardization of experimental design and data analysis, and that the analysis of protein changes in specific neuronal cell types in the central nervous system remains a serious challenge, it appears that the quality and depth of the more recent quantitative proteomics studies is beginning to shed

  16. Recent advances in electrodriven enantioseparations.

    PubMed

    Jáč, Pavel; Scriba, Gerhard K E

    2013-01-01

    Capillary electromigration techniques have developed into significant analytical separation tools especially for enantioseparations. While CE can be considered a mature technique as documented by its wide applications, CEC is still in a developmental state despite many research efforts. The success of stereospecific CE separation methods is due to the high specificity and flexibility of the technique as well as the availability of many types of chiral selectors. Thus, numerous methods have been developed for the analysis of chiral compounds in chemical, biochemical, pharmaceutical, environmental, and forensic sciences. However, most reported applications deal with pharmaceuticals. The search for new chiral selectors also continued despite the fact that most applications were performed using cyclodextrins. Furthermore, CE has been combined with spectroscopic and molecular modeling studies in attempts to understand the interactions between chiral selectors and analytes. The present review focuses on recent examples of mechanistic aspects of capillary enantioseparations with regard to mathematical modeling of enantioseparations, investigations of the analyte-complex structures as well as new chiral selectors and applications of chiral analyses by CE and CEC. It covers the literature published between January 2011 and August 2012. PMID:23255223

  17. Recent developments in bimetric theory

    NASA Astrophysics Data System (ADS)

    Schmidt-May, Angnis; von Strauss, Mikael

    2016-05-01

    This review is dedicated to recent progress in the field of classical, interacting, massive spin-2 theories, with a focus on ghost-free bimetric theory. We will outline its history and its development as a nontrivial extension and generalisation of nonlinear massive gravity. We present a detailed discussion of the consistency proofs of both theories, before we review Einstein solutions to the bimetric equations of motion in vacuum as well as the resulting mass spectrum. We introduce couplings to matter and then discuss the general relativity and massive gravity limits of bimetric theory, which correspond to decoupling the massive or the massless spin-2 field from the matter sector, respectively. More general classical solutions are reviewed and the present status of bimetric cosmology is summarised. An interesting corner in the bimetric parameter space which could potentially give rise to a nonlinear theory for partially massless spin-2 fields is also discussed. Relations to higher-curvature theories of gravity are explained and finally we give an overview of possible extensions of the theory and review its formulation in terms of vielbeins.

  18. Recent progress in rock magnetism

    NASA Astrophysics Data System (ADS)

    Courtillot, Vincent

    Availability of affordable high-performance computers has spurred research into the mathematical modelling of magnetic domain structures, stability of magnetic remanences and their experimental verification. Further, a recently substantially increased amount of observations of magnetic minerals other than magnetite in natural rocks has intitiated studies of their fundamental magnetic properties. To provide a forum for discussion of the latest developments covering these important subjects, two symposia were organized at the XXI General Assembly of the International Union of Geodesy and Geophysics (Boulder, Colorado, USA, July 2-14, 1995): New Approaches in Rock Magnetism (convened by S.L. Halgedahl and F. Heider) and Properties of minor magnetic minerals (convened by MJ. Dekkers and E. McClelland). In total 62 contributions were presented. This special section of Geophysical Research Letters comprises 19 papers, meeting, hopefully some of the most significant. The four convenors assisted me as associate-editors in preparing this special issue, and I would like to thank them. The time taken by many reviewers is also appreciated. I hope the reader will get a feeling of the excitement that was evident during the Boulder meeting and will find this a useful collection of articles for later use.

  19. Recent advances in understanding psoriasis

    PubMed Central

    Eberle, Franziska C.; Brück, Jürgen; Holstein, Julia; Hirahara, Kiyoshi; Ghoreschi, Kamran

    2016-01-01

    T helper (Th) cells producing interleukin (IL)-17, IL-22, and tumor necrosis factor (TNF) form the key T cell population driving psoriasis pathogenesis. They orchestrate the inflammation in the skin that results in the proliferation of keratinocytes and endothelial cells. Besides Th17 cells, other immune cells that are capable of producing IL-17-associated cytokines participate in psoriatic inflammation. Recent advances in psoriasis research improved our understanding of the cellular and molecular players that are involved in Th17 pathology and inflammatory pathways in the skin. The inflammation-driving actions of TNF in psoriasis are already well known and antibodies against TNF are successful in the treatment of Th17-mediated psoriatic skin inflammation. A further key cytokine with potent IL-17-/IL-22-promoting properties is IL-23. Therapeutics directly neutralizing IL-23 or IL-17 itself are now extending the therapeutic spectrum of antipsoriatic agents and further developments are on the way. The enormous progress in psoriasis research allows us to control this Th17-mediated inflammatory skin disease in many patients. PMID:27158469

  20. BOUT++: Recent and current developments

    NASA Astrophysics Data System (ADS)

    Dudson, B. D.; Allen, A.; Breyiannis, G.; Brugger, E.; Buchanan, J.; Easy, L.; Farley, S.; Joseph, I.; Kim, M.; McGann, A. D.; Omotani, J. T.; Umansky, M. V.; Walkden, N. R.; Xia, T.; Xu, X. Q.

    2015-01-01

    BOUT++ is a 3D nonlinear finite-difference plasma simulation code, capable of solving quite general systems of Partial Differential Equations (PDEs), but targeted particularly on studies of the edge region of tokamak plasmas. BOUT++ is publicly available, and has been adopted by a growing number of researchers worldwide. Here we present improvements which have been made to the code since its original release, both in terms of structure and its capabilities. Some recent applications of these methods are reviewed, and areas of active development are discussed. We also present algorithms and tools which have been developed to enable creation of inputs from analytic expressions and experimental data, and for processing and visualisation of output results. This includes a new tool Hypnotoad for the creation of meshes from experimental equilibria. Algorithms have been implemented in BOUT++ to solve a range of linear algebraic problems encountered in the simulation of reduced Magnetohydrodynamics (MHD) and gyro-fluid models: A preconditioning scheme is presented which enables the plasma potential to be calculated efficiently using iterative methods supplied by the PETSc library (the Portable, Extensible Toolkit for Scientific Computation) (Balay et al. 2014), without invoking the Boussinesq approximation. Scaling studies are also performed of a linear solver used as part of physics-based preconditioning to accelerate the convergence of implicit time-integration schemes.

  1. [Gastroenterology: recent advances and perspectives].

    PubMed

    Dobrilla, Giorgio

    2006-12-01

    Among the significant current topics in gastroenterology, the endoscopic capsule, virtual colonography, and ischaemic colitis deserve special considerations. Main indications of the endoscopic capsule are the diagnosis of small intestinal (bleeding) angiodysplasias, Crohn's lesions and tumours. The main drawbacks are gastrointestinal blockage of the capsule due to stenosis and flat batteries before the capsule reaches the distal small intestine. Future advantages may stem from a wider pre-use of an auto-digestible capsule capable of pre-cautionary excluding stenotic gastrointestinal segments ant the pill-cam for the evaluation of the oesophagus. Virtual colonography is a promising and attractive non-invasive alternative for the detection of tumoral colonic lesions (polyps and cancers). Its specific role as a screening procedure or investigation of symptomatic patients has to be better established. In a near future development of patients-friendly bowel preparation, high standard level of the evaluators and advances in computed software should likely allow a better definition of its overall potential. Ischaemic colitis is still a very difficult proposition for gastroenterologists and surgeons from any point of view. Its prompt recognition is a very significant advantage for the therapy. In addition to the advances in diagnostics and therapy, recent data have been reported as far as the pathogenesis of ischaemic colitis is concerned. Useful information has paradoxically come from the side effects of the 5-HT3 antagonists and 5-HT4 agonists used in treatment of irritable bowel syndrome patients. PMID:17252732

  2. Overview of recent HERMES results

    NASA Astrophysics Data System (ADS)

    Marukyan, Hrachya

    2016-02-01

    An overview of more recent and important results from the HERMES experiment are presented in this paper. HERMES collected a wealth of data using the 27.6 GeV polarized HERA lepton beam and various polarized and unpolarized gaseous targets. This unique data set opens the door to the measurements of observables sensitive to the multidimensional structure of the nucleon. Among them are semi-inclusive deep-inelastic scattering measurements of azimuthal modulations sensitive to the transverse momentum distributions, such as the leading- twist Sivers and Collins distributions and distributions sensitive to the convolutions of the twist-2 and twist-3 functions. They all provide an information on the three-momentum-dependent quark distributions. Knowledge on the quark distribution as a function of longitudinal momentum and transverse position in impact-parameter space can be accessed, e.g., through exclusive ω—meson leptoproduction, particularly through the measurement of spin density matrix elements and the measurement of azimuthal modulations on transversely polarized proton target. The measurement of Bose-Einstein correlations of hadron pairs in quasi-real leptoproduction are also presented. The transverse polarization of Λ hyperons measured again in quasi-real leptoproduction regime are presented as well. Finally, the new analysis for the search on pentaquark at HERMES are mentioned.

  3. Recent status of stereotaxic surgery.

    PubMed

    Narabayashi, H

    1983-06-01

    Another important technical advance is the development of computed tomography (CT) instrumentation. The most recent equipment is able to detect lesions 2 mm in diameter. When the stereotaxic frame is exactly adjusted to the CT axis, the structures in the depth of the brain can be visualized and localized and can be referred to the three-dimensional coordinates of the stereotaxic instrument. This will enable the exact insertion of the stereotaxic needle to a small tumor lying in the depth of the brain or to some type of vascular lesions. Three-dimensional angiography would also provide the detailed information about such deep-lying tumors and their blood supply. It is highly probable that further advances in tomographic instrumentation will take the place of pneumoventriculography or positive contrast ventriculography, even in cases of functional stereotaxis. However, the importance of using the sophisticated physiologic methods previously described remains the same. At present, these new developments are still at the stage of designing instrumentation. Much is expected in the future. In summary, stereotaxic surgery is a selective technique to approach deep-lying structures in the human brain. It enables us to examine and treat the pathology in the depth of the brain. The important and necessary attitude of the scientist is how to understand the nature of the symptoms and the diseases, on which the prognostic value of the lifelong treatment may depend. PMID:6344289

  4. Recent Advances in Nuclear Cardiology.

    PubMed

    Lee, Won Woo

    2016-09-01

    Nuclear cardiology is one of the major fields of nuclear medicine practice. Myocardial perfusion studies using single-photon emission computed tomography (SPECT) have played a crucial role in the management of coronary artery diseases. Positron emission tomography (PET) has also been considered an important tool for the assessment of myocardial viability and perfusion. However, the recent development of computed tomography (CT)/magnetic resonance imaging (MRI) technologies and growing concerns about the radiation exposure of patients remain serious challenges for nuclear cardiology. In response to these challenges, remarkable achievements and improvements are currently in progress in the field of myocardial perfusion imaging regarding the applicable software and hardware. Additionally, myocardial perfusion positron emission tomography (PET) is receiving increasing attention owing to its unique capability of absolute myocardial blood flow estimation. An F-18-labeled perfusion agent for PET is under clinical trial with promising interim results. The applications of F-18 fluorodeoxyglucose (FDG) and F-18 sodium fluoride (NaF) to cardiovascular diseases have revealed details on the basic pathophysiology of ischemic heart diseases. PET/MRI seems to be particularly promising for nuclear cardiology in the future. Restrictive diseases, such as cardiac sarcoidosis and amyloidosis, are effectively evaluated using a variety of nuclear imaging tools. Considering these advances, the current challenges of nuclear cardiology will become opportunities if more collaborative efforts are devoted to this exciting field of nuclear medicine. PMID:27540423

  5. Recent experiences with nocardial infections.

    PubMed

    Rosett, W; Hodges, G R

    1978-01-01

    A review of Nocardia isolates at two Kansas City hospitals from 1968 to 1976 revealed isolates from 42 different patients. Data were available for analysis from 36 patients. According to strict criteria, only 17(47%) were infected. Infection increased from zero to one yearly from 1968 through 1973 to five and seven in 1974 and 1975, respectively. Commensal isolates varied from zero to five yearly with no recent increase. Analysis of underlying disease and predisposing factors suggests that bronchopulmonary abnormalities predispose to colonization but infection is unusual without immunosuppression. Primary nocardial infection without known underlying disease accounted for only 4 of the 17(24%) infections. Fever and leukocytosis were not helpful in distinguishing nocardial infection from colonization. A history of prior steroid use and a smear showing gram-positive filamentous organisms correlated highly with infection. Mortality correlated with pulmonary and brain involvement, prior use of steroids, and inappropriate therapy. Nosocomial infection was noted in five patients with a mortality of 60%. Overall mortality was only 29%. PMID:742635

  6. Illuminating cellular physiology: recent developments.

    PubMed

    Brovko, Lubov Y; Griffiths, Mansel W

    2007-01-01

    Bioluminescent methods are gaining more and more attention among scientists due to their sensitivity, selectivity and simplicity; coupled with the fact that the bioluminescence can be monitored both in vitro and in vivo. Since the discovery of bioluminescence in the 19th century, enzymes involved in the bioluminescent process have been isolated and cloned. The bioluminescent reactions in several different organisms have also been fully characterized and used as reporters in a wide variety of biochemical assays. From the 1990s it became clear that bioluminescence can be detected and quantified directly from inside a living cell. This gave rise to numerous possibilities for the in vivo monitoring of intracellular processes non-invasively using bioluminescent molecules as reporters. This review describes recent developments in the area of bioluminescent imaging for cell biology. Newly developed imaging methods allow transcriptional/translational regulation, signal transduction, protein-protein interaction, oncogenic transformation, cell and protein trafficking, and target drug action to be monitored in vivo in real-time with high temporal and spatial resolution; thus providing researchers with priceless information on cellular functions. Advantages and limitations of these novel bioluminescent methods are discussed and possible future developments identified. PMID:17725230

  7. Small gauge vitrectomy: Recent update

    PubMed Central

    Khanduja, Sumeet; Kakkar, Ashish; Majumdar, Saptrishi; Vohra, Rajpal; Garg, Satpal

    2013-01-01

    Small gauge vitrectomy, also known as minimally invasive vitreous surgery (MIVS), is a classic example of progress in biomedical engineering. Disparity in conjunctival and scleral wound location and reduction in wound diameter are its core principles. Fluidic changes include increased pressure head loss with consequent reduction in infusional flow rate and use of higher aspiration vacuum at the cutter port. Increase An increase in port open/port closed time maintains an adequate rate of vitreous removal. High Intensity Discharge (HID) lamps maintain adequate illumination in spite of a decrease in the number of fiberoptic fibers. The advantages of MIVS are, a shorter surgical time, minimal conjunctival damage, and early postoperative recovery. Most complications are centered on wound stability and risk of postoperative hypotony, endophthalmitis, and port site retinal break formation. MIVS is suited in most cases, however, it can cause dehiscence of recent cataract wounds. Retraction of the infusion cannula in the suprachoroidal space may occur in eyes with scleral thinning. As a lot has been published and discussed about sutureless vitrectomy a review of this subject is necessary. A PubMed search was performed in December 2011 with terms small gauge vitrectomy, 23-gauge vitrectomy, 25-gauge vitrectomy, and 27 gauge vitrectomy, which were revised in August 2012. There were no restrictions on the date of publication but it was restricted to articles in English or other languages, if there abstracts were available in English. PMID:23772118

  8. Recent trends in fructooligosaccharides production.

    PubMed

    Guío, Felipe; Rodríguez, Mauro A; Alméciga-Diaz, Carlos J; Sánchez, Oscar F

    2009-11-01

    Prebiotics are food ingredients that promote host health beneficially due to their effect over the growth and activity of probiotic bacterial species. Prebiotic properties have been demonstrated for inulin-type fructans, galactoolicosaccharides and lactulose. Fructooligosaccharides (FOS), considered as inulin-type fructans, represent an important source of prebiotic compounds that are widely used as an ingredient in functional foods. FOS are produced by the action of fructosyltransferase from many plants, fungi and bacteria, and they are mainly composed of 1-kestose, nystose, and 1-beta-fructofuranosyl nystose. Among them, 1-kestose has better therapeutic properties than those with a high polymeric degree (GF(n > 4)). FOS exhibited properties than those with a high polymeric degree (GF(n>4)). FOS exhibited properties such as low caloric values, non-cariogenic properties, decrease levels of lipids and cholesterol, help gut absorption of ions, and stimulate the bifidobacteria growth in the human colon. This review presents a summary of the patents related with FOS production by industrial sucrose biotransformation or the use of recombinant fructosyltransferase enzymes. Also, a brief description of recent FOS applications will be discussed. PMID:20653543

  9. Recent developments in superconducting receivers

    SciTech Connect

    Richards, P.L.

    1990-09-01

    A description is given of recent work at Berkeley on superconducting mixers and detectors for infrared and millimeter wavelengths. The first report is a review article which summarizes the status of development of superconducting components for infrared and millimeter wave receivers. The next report describes accurate measurements and also theoretical modeling of an SIS quasiparticle waveguide mixer for W-band which uses very high quality Ta junctions. The best mixer noise is only 1.3 times the quantum limit. Both the mixer gain and the noise are in quantitative agreement with the quantum theory. Next, a report is given on measurements and theoretical modeling of the absorptivity (surface resistance) of high quality epitaxial films of the high {Tc} superconductor YBCO from 750 GHz to 21 THz. Finally, there are reports on the design and experimental performance of two different types of high {Tc} bolometric detectors. One is a conventional bolometer with a gold-black absorber. The other is an antenna coupled microbolometer.

  10. Recent Developments in Myofibroblast Biology

    PubMed Central

    Hinz, Boris; Phan, Sem H.; Thannickal, Victor J.; Prunotto, Marco; Desmoulière, Alexis; Varga, John; De Wever, Olivier; Mareel, Marc; Gabbiani, Giulio

    2013-01-01

    The discovery of the myofibroblast has opened new perspectives for the comprehension of the biological mechanisms involved in wound healing and fibrotic diseases. In recent years, many advances have been made in understanding important aspects of myofibroblast basic biological characteristics. This review summarizes such advances in several fields, such as the following: i) force production by the myofibroblast and mechanisms of connective tissue remodeling; ii) factors controlling the expression of α-smooth muscle actin, the most used marker of myofibroblastic phenotype and, more important, involved in force generation by the myofibroblast; and iii) factors affecting genesis of the myofibroblast and its differentiation from precursor cells, in particular epigenetic factors, such as DNA methylation, microRNAs, and histone modification. We also review the origin and the specific features of the myofibroblast in diverse fibrotic lesions, such as systemic sclerosis; kidney, liver, and lung fibrosis; and the stromal reaction to certain epithelial tumors. Finally, we summarize the emerging strategies for influencing myofibroblast behavior in vitro and in vivo, with the ultimate goal of an effective therapeutic approach for myofibroblast-dependent diseases. PMID:22387320

  11. Recent advances in tropical medicine.

    PubMed

    Solomon, Anthony W; Nayagam, Shevanthi; Pasvol, Geoffrey

    2009-07-01

    There have been significant advances in both the classical and neglected tropical diseases, with Guinea worm looking set to be the next disease after smallpox to be eradicated. Aided by a combination of enhanced understanding of the biology of the pathogens, intensification of immunisation activities or mass drug administration, together with the development of synergies with control programmes for co-endemic tropical diseases, polio, lymphatic filariasis, trachoma and onchocerciasis all appear to be in global decline, with good prospects for eventual successful elimination. While the global incidence of new cases of leprosy continues to decrease, the focus of leprosy control efforts has shifted following more widespread recognition that cure of infection does not necessarily prevent disability. Expansion in funding for HIV/AIDS and malaria provides some grounds for optimism about the control of these diseases. However, ongoing education and access remain essential to increasing the uptake of HIV testing and decreasing transmission. Meanwhile, the rise of drug-resistant tuberculosis and malaria is concerning, and the emergence of the highly pathogenic avian influenza A and re-emergence of viruses such as chikungunya and West Nile virus, without significant recent progress in vaccine development, pose additional ongoing challenges to tropical medicine physicians worldwide. PMID:19233443

  12. Recent developments in SAC2000

    SciTech Connect

    Goldstein, P.; Dodge, D.; Firpo, M

    1997-07-01

    Before discussing recent developments in SAC2000, I will summarize what SAC2000 is/does. SAC2000 is the rebirth and evolution of Lawrence Livermore National Laboratory`s (LLNL`s) Seismic Analysis Code (SAC) developed during the 1980`s for a variety of geophysical applications. Primary funding for the development of SAC2000 has been through the LLNL as part of the Department of Energy`s (DOE`s) CTBT R&D program. The primary development goals for SAC2000 have been to meet the seismic signal processing and analysis needs of the DOE CTBT R&D teams and the rest of the CTBT R&D community. SAC2000`s strengths include its ability to process a diverse range of data types, its extensive, well documented signal processing capabilities (both on-line and on the web at http://www-ep.es.llnl.gov/tvp/sac.html), its macro language, and its ability to do both branch and interactive processing. Its extensive usage (over 200 institutions worldwide) had also made it much easier for researchers to develop collaborative research projects. SAC2000`s extensive signal processing capabilities include: data inspection, signal correction, and quality control, unary and binary data operations, travel-time analysis, spectral analysis including high-resolution spectral estimation, spectrograms and binary sonograms, and array and three-component analysis. Recent development in SAC2000 include: enhanced compatibility with the CSS3.0 database schema, complete compatibility with the widely used SEED data format instrument responses, map making capabilities via an interface to GMT, a new three component polarization and phase identification tool, an external interface that allows users to define their own commands, and an interface to MATLAB that allows the user to use MATLAB commands and scripts on SAC data from within SAC2000. We have also implemented a number of commands to enhance user efficiency and numerous improvements and enhancements to many individual SAC commands. Current development in SAC

  13. [Recent advances in allergic rhinitis].

    PubMed

    Liang, Meijun; Xu, Rui; Xu, Geng

    2015-02-01

    Allergic rhinitis (AR) clinically expressed by sneezing, rhinorrhea, nasal itching and congestion is an allergen-driven mucosal inflammatory disease which is modulated by immunoglobulin E. Epidemiological studies have indicated that prevalence of AR continues to increase, and it has been a worldwide health problem that places a significant healthcare burden on individuals and society. Given the evolving understanding of the process by which an allergen is recognized and the roles of mediators which account for AR progress, the pathogenesis of AR has become clearer. Current studies have demonstrated local allergic rhinitis (LAR) that patients with both sug- gestive symptoms of AR and a negative diagnostic test for atopy may have local allergic inflammation is a prevalent entity in patients evaluated with rhinitis, but further research remains needed. Management of AR includes aller- gen avoidance, pharmacological treatment and allergen-specific immunotherapy. Recently montelukast has exhibited previously undocumented anti-inflammatory properties, leukotriene receptor antagonists therefore may serve a more important role in the treatment of AR. Not only has immunotherapy proved its efficacy, but also been able to alter disease course and thereby mitigate progression to asthma. Thus immunotherapy can be initiated while receiving pharmacotherapy, especially in children with AR. As clinical guidelines, the ARIA (Allergic Rhinitis and its Impact on Asthma) provides basic principles of effective treatment of AR. Besides, choosing an appropriate treatment strategy should be based on the severity and chronicity of patient's symptom. The aim of this review was to provide an update mainly on the pathophysiology, epidemiology, and management of AR. PMID:26012287

  14. Recent progress in allergen immunotherapy.

    PubMed

    Nouri-Aria, Kayhan T

    2008-03-01

    The efficacy of allergen immunotherapy for the treatment of allergic rhinoconjunctivitis with or without seasonal bronchial asthma and anaphylaxis caused by the sting of the hymenoptera class of insects has been clearly demonstrated in numerous well-designed, placebo-controlled trials. Immunotherapy whether by subcutaneous injection of allergen extract or by oral/sublingual routes modifies peripheral and mucosal TH2 responses in favour of TH1 responses and augments IL-10 synthesis by TRegs both locally and by peripheral T cells. Recent researches into the cellular and molecular basis of allergic reactions have advanced our understanding of the mechanisms involved in allergic diseases. They have also helped the development of innovative approaches that are likely to further improve the control of allergic responses in the future. Novel approaches to immunotherapy that are currently being explored include the use of peptide-based allergen preparations, which do not bind IgE and therefore do not activate mast cells, but reduce both Th1 and Th2-cytokine synthesis, while increasing levels of IL-10. Alternative strategies include the use of adjuvants, such as nucleotide immunostimulatory sequences derived from bacteria CpG or monophosphoryl lipid A that potentiate Th1 responses. Blocking the effects of IgE using anti-IgE such as omalizumab, a recombinant humanized monoclonal antibody that selectively binds to IgE, has been shown to be a useful strategy in the treatment of allergic asthma and rhinitis. The combination of anti-IgE-monoclonal antibody omalizumab with allergen immunotherapy has proved beneficial for the treatment of allergic diseases, offering improved efficacy, limited adverse effects, and potential immune-modifying effects. This combination may also accelerate the rapidity by which immunotherapy induces TReg cells. If allergic diseases are due to a lack of allergen-specific TReg cells, then effective therapies should target the induction and the

  15. PT quantum mechanics - Recent results

    NASA Astrophysics Data System (ADS)

    Bender, Carl M.

    2012-09-01

    Most quantum physicists believe that a quantum-mechanical Hamiltonian must be Dirac Hermitian (invariant under matrix transposition and complex conjugation) to be sure that the energy eigenvalues are real and that time evolution is unitary. However, the non-Dirac-hermitian Hamiltonian H = p2+ix3 has a real positive discrete spectrum and generates unitary time evolution and defines a fully consistent and physical quantum theory. Evidently, Dirac Hermiticity is too restrictive. While H = p2+ix3 is not Dirac Hermitian, it is PT symmetric (invariant under combined space reflection P and time reversal T). Another PT-symmetric Hamiltonian whose energy levels are real, positive and discrete is H = p2-x4, which contains an upside-down potential. The quantum mechanics defined by a PT-symmetric Hamiltonian is a complex generalization of ordinary quantum mechanics. When quantum mechanics and quantum field theory are extended into the complex domain, new kinds of theories having strange and remarkable properties emerge. In the past two years some of these properties have been verified in laboratory experiments. Here, we first discuss PT-symmetric Hamiltonians at a simple intuitive level and explain why the energy levels of such Hamiltonians may be real, positive, and discrete. Second, we describe a recent experiment in which the PT phase transition was observed. Third, we briefly mention that PT-symmetric theories can be useful at a fundamental level. While the double-scaling limit of an O(N)-symmetric gφ4 quantum field theory appears to be inconsistent because the critical value of g is negative, this limit is in fact not inconsistent because the critical theory is PT symmetric.

  16. Recent advances in understanding vitiligo

    PubMed Central

    Manga, Prashiela; Elbuluk, Nada; Orlow, Seth J.

    2016-01-01

    Vitiligo, an acquired depigmentation disorder, manifests as white macules on the skin and can cause significant psychological stress and stigmatization. Recent advances have shed light on key components that drive disease onset and progression as well as therapeutic approaches. Vitiligo can be triggered by stress to the melanin pigment-producing cells of the skin, the melanocytes. The triggers, which range from sunburn to mechanical trauma and chemical exposures, ultimately cause an autoimmune response that targets melanocytes, driving progressive skin depigmentation. The most significant progress in our understanding of disease etiology has been made on three fronts: (1) identifying cellular responses to stress, including antioxidant pathways and the unfolded protein response (UPR), as key players in disease onset, (2) characterizing immune responses that target melanocytes and drive disease progression, and (3) identifying major susceptibility genes. The current model for vitiligo pathogenesis postulates that oxidative stress causes cellular disruptions, including interruption of protein maturation in the endoplasmic reticulum (ER), leading to the activation of the UPR and expression of UPR-regulated chemokines such as interleukin 6 (IL-6) and IL-8. These chemokines recruit immune components to the skin, causing melanocytes to be targeted for destruction. Oxidative stress can further increase melanocyte targeting by promoting antigen presentation. Two key components of the autoimmune response that promote disease progression are the interferon (IFN)-γ/CXCL10 axis and IL-17-mediated responses. Several genome-wide association studies support a role for these pathways, with the antioxidant gene NRF2, UPR gene XBP1, and numerous immune-related genes including class I and class II major histocompatibility genes associated with a risk for developing vitiligo. Novel approaches to promote repigmentation in vitiligo are being investigated and may yield effective, long

  17. Recent Results on Singularity Strengths

    NASA Astrophysics Data System (ADS)

    Nolan, Brien

    2002-12-01

    In this contribution, we review some recent results on strengths of singularities. In a space-time (M,g), let γ[τ0, 0) → M be an incomplete, inextendible causal geodesic, affinely parametrised by τ, tangent ěc k. Let Jτ1 :=set of Jacobi fields along γ, orthogonal to γ and vanishing at time τ1 ≥ τ0 i.e. ěc ξ ∈ J{τ 1 } iff D2ξa = -Rbcdakbkdξc, gabξakb = 0, and ěc ξ (τ 1 ) = 0. Vτ1(τ) := volume element defined by full set of independent elements of Jτ1 (2-dim for null geodesies, 3-dim for time-like); Vτ1 := ∥Vτ1∥. Definition (Tipler 1977): γ terminates in a gravitationally strong singularity if for all 0 > τ1 ≥ τ0, lim infτ→0- Vτ1(τ) = 0. γ... gravitationally weak ... lim infτ→0- Vτ1(τ) > 0. The interpretation is that at a strong singularity, an extended body, e.g. a gravitational wave detector, is crushed to zero volume by the singularity. Tipler's definition does not take account of the possibility that (i) V → ∞ or (ii) V → finite, non-zero value, but with infinite stretching/crushing in orthogonal directions ('spaghettifying singularity'). Extended definition (Nolan 1999): strong if either V → 0,∞ or if for every τ1, there is an element ěc ξ of Jτ1 satisfying ||ěc ξ || -> 0. Otherwise weak. (Ori 2000): singularity is 'deformationally strong' if either (i) it is Tipler-strong or (ii) for every τ1, there is an element ěc ξ of Jτ1 satisfying ||ěc ξ || -> ∞ . Otherwise, deformationally weak...

  18. Recent development in PET instrumentation.

    PubMed

    Peng, By Hao; Levin, Craig S

    2010-09-01

    Positron emission tomography (PET) is used in the clinic and in vivo small animal research to study molecular processes associated with diseases such as cancer, heart disease, and neurological disorders, and to guide the discovery and development of new treatments. This paper reviews current challenges of advancing PET technology and some of newly developed PET detectors and systems. The paper focuses on four aspects of PET instrumentation: high photon detection sensitivity; improved spatial resolution; depth-of-interaction (DOI) resolution and time-of-flight (TOF). Improved system geometry, novel non-scintillator based detectors, and tapered scintillation crystal arrays are able to enhance the photon detection sensitivity of a PET system. Several challenges for achieving high resolution with standard scintillator-based PET detectors are discussed. Novel detectors with 3-D positioning capability have great potential to be deployed in PET for achieving spatial resolution better than 1 mm, such as cadmium-zinc-telluride (CZT) and position-sensitive avalanche photodiodes (PSAPDs). DOI capability enables a PET system to mitigate parallax error and achieve uniform spatial resolution across the field-of-view (FOV). Six common DOI designs, as well as advantages and limitations of each design, are discussed. The availability of fast scintillation crystals such as LaBr(3), and the silicon photomultiplier (SiPM) greatly advances TOF-PET development. Recent instrumentation and initial results of clinical trials are briefly presented. If successful, these technology advances, together with new probe molecules, will substantially enhance the molecular sensitivity of PET and thus increase its role in preclinical and clinical research as well as evaluating and managing disease in the clinic. PMID:20497121

  19. The future of PanDA in ATLAS distributed computing

    NASA Astrophysics Data System (ADS)

    De, K.; Klimentov, A.; Maeno, T.; Nilsson, P.; Oleynik, D.; Panitkin, S.; Petrosyan, A.; Schovancova, J.; Vaniachine, A.; Wenaus, T.

    2015-12-01

    Experiments at the Large Hadron Collider (LHC) face unprecedented computing challenges. Heterogeneous resources are distributed worldwide at hundreds of sites, thousands of physicists analyse the data remotely, the volume of processed data is beyond the exabyte scale, while data processing requires more than a few billion hours of computing usage per year. The PanDA (Production and Distributed Analysis) system was developed to meet the scale and complexity of LHC distributed computing for the ATLAS experiment. In the process, the old batch job paradigm of locally managed computing in HEP was discarded in favour of a far more automated, flexible and scalable model. The success of PanDA in ATLAS is leading to widespread adoption and testing by other experiments. PanDA is the first exascale workload management system in HEP, already operating at more than a million computing jobs per day, and processing over an exabyte of data in 2013. There are many new challenges that PanDA will face in the near future, in addition to new challenges of scale, heterogeneity and increasing user base. PanDA will need to handle rapidly changing computing infrastructure, will require factorization of code for easier deployment, will need to incorporate additional information sources including network metrics in decision making, be able to control network circuits, handle dynamically sized workload processing, provide improved visualization, and face many other challenges. In this talk we will focus on the new features, planned or recently implemented, that are relevant to the next decade of distributed computing workload management using PanDA.

  20. Recent Advances in Geostatistical Inversion

    NASA Astrophysics Data System (ADS)

    Kitanidis, P. K.

    2011-12-01

    Inverse problems are common in hydrologic applications, such as in subsurface imaging which is the identification of parameters characterizing geologic formations from hydrologic and geophysical observations. In such problems, the data do not suffice to constrain the solution to be unique. The geostatistical approach utilizes probability theory and statistical inference to assimilate data and information about structure and to explore the range of possible solutions in a systematic way. This is a progress report on recent advances in terms of formulation and computational methods. The standard implementation of the geostatistical approach to the inverse method is computationally very expensive when there are millions of unknowns and hundreds of thousands of observations, as is the case in fusing data from many sources in hydrogeology. However, depending on the specific problem, alternative formulations and numerical methods can reduce the computational problem quite dramatically. One approach can utilize formulations that involve matrices with a very high degree of sparsity combined with indirect methods of solution and strategies that minimize the number of required forward runs. The potential for this method is illustrated with an application to transient hydraulic tomography. Another approach speeds up matrix-vector multiplications by utilizing hierarchical sparsity in commonly encountered matrices, particularly prior covariance matrices. A couple of examples show how the computational cost scales with the size of the problem (number of observations and unknowns) in conventional and newer methods. Yet another fruitful approach is to rely on a large number of realizations to represent ensembles of solutions and we illustrate this approach in fusing data from two different geophysical methods. In all of these approaches, utilizing parallel processors and mixed CPU/GPU programming can significantly reduce the computational cost and make it possible to solve very

  1. Recent Advances in Petroleum Microbiology

    PubMed Central

    Van Hamme, Jonathan D.; Singh, Ajay; Ward, Owen P.

    2003-01-01

    Recent advances in molecular biology have extended our understanding of the metabolic processes related to microbial transformation of petroleum hydrocarbons. The physiological responses of microorganisms to the presence of hydrocarbons, including cell surface alterations and adaptive mechanisms for uptake and efflux of these substrates, have been characterized. New molecular techniques have enhanced our ability to investigate the dynamics of microbial communities in petroleum-impacted ecosystems. By establishing conditions which maximize rates and extents of microbial growth, hydrocarbon access, and transformation, highly accelerated and bioreactor-based petroleum waste degradation processes have been implemented. Biofilters capable of removing and biodegrading volatile petroleum contaminants in air streams with short substrate-microbe contact times (<60 s) are being used effectively. Microbes are being injected into partially spent petroleum reservoirs to enhance oil recovery. However, these microbial processes have not exhibited consistent and effective performance, primarily because of our inability to control conditions in the subsurface environment. Microbes may be exploited to break stable oilfield emulsions to produce pipeline quality oil. There is interest in replacing physical oil desulfurization processes with biodesulfurization methods through promotion of selective sulfur removal without degradation of associated carbon moieties. However, since microbes require an environment containing some water, a two-phase oil-water system must be established to optimize contact between the microbes and the hydrocarbon, and such an emulsion is not easily created with viscous crude oil. This challenge may be circumvented by application of the technology to more refined gasoline and diesel substrates, where aqueous-hydrocarbon emulsions are more easily generated. Molecular approaches are being used to broaden the substrate specificity and increase the rates and

  2. Recent Surface Changes on Mars

    NASA Astrophysics Data System (ADS)

    Geissler, P. E.; Mukherjee, P.

    2010-12-01

    The MARCI camera on Mars Reconnaissance Orbiter has now been making global observations of the Martian surface for over two Martian years with better spatial resolution and better spectral definition than earlier visible imaging systems. These observations extend the record of continuous global monitoring of the planet's surface that dates from the arrival of Mars Global Surveyor (MGS) in 1999. The orbital images show a dynamic and rapidly changing pattern of bright and dark regions generated by erosion and deposition of sediments by the Martian winds. Previous analyses of the MGS MOC images (Geissler et al., AGU 2009) showed that the temporal behavior of surface albedo varied with geographic location on the planet, with some regions exhibiting gradual changes, while others showed episodic changes that typically took place during the perihelion season, and still other regions such as Solis that appeared to change on a quasi-continuous basis. These observations help to explain the significant changes observed on a decadal time scale between the era of the Viking Orbiters and the arrival of MGS (Geissler, 2005, 1029/2004JE2345). The MARCI data so far confirm many of the conclusions drawn from the MOC record up to the end of 2006. Over the most recent two Martian years, dramatic changes continued in the Solis Lacus region south of the Vallis Marineris. Another episodic wind event stripped away bright dust and darkened the area west of Syrtis Major. New dust accumulations were deposited in the southern mid-latitudes west of Hellas. Most interesting is the gradual advance of many albedo boundaries in the tropical latitudes of Mars. In several locations, dark terrain appears to be encroaching on formerly bright terrain as bright dust is stripped away from the region. MOC and MARCI observations show that these albedo boundaries are moving at speeds of up to tens of kilometers per Martian year. At sites such as Hyblaeus (west of Elysium), the Southern Tropical Dark Band

  3. Identification of sequence similarity between 60 kDa and 70 kDa molecular chaperones: evidence for a common evolutionary background?

    PubMed Central

    Flores, A I; Cuezva, J M

    1997-01-01

    Recent findings support the premise that chaperonins (60 kDa stress-proteins) and alpha-subunits of F-type ATPases (alpha-ATPase) are evolutionary related protein families. Two-dimensional gel patterns of synthesized proteins in unstressed and heat-shocked embryonic Drosophila melanogaster SL2 cells revealed that antibodies raised against the alpha-subunit of the F1-ATPase complex from rat liver recognize an inducible p71 member of the 70 kDa stress-responsive protein family. Molecular recognition of this stress-responsive 70 kDa protein by antibodies raised against the F1-ATPase alpha-subunit suggests the possibility of partial sequence similarity within these ATP-binding protein families. A multiple sequence alignment between alpha-ATPases and 60 kDa and 70 kDa molecular chaperones is presented. Statistical evaluation of sequence similarity reveals a significant degree of sequence conservation within the three protein families. The finding suggests a common evolutionary origin for the ATPases and molecular chaperone protein families of 60 kDa and 70 kDa, despite the lack of obvious structural resemblance between them. PMID:9065788

  4. Recent Impacts on the Moon

    NASA Astrophysics Data System (ADS)

    Robinson, M. S.; Bowles, Z. R.; Daubar, I.; Povilaitis, R.; Thompson, S. D.; Thompson, T. J.; Wagner, R.

    2013-12-01

    Prior to Lunar Reconnaissance Orbiter (LRO) observations, an understanding of impact rates of meteoroids <1 m in size was based on extrapolation techniques from near-Earth object (NEO) knowledge [1,2,3], meteors in Earth's atmosphere [4], recent impacts recorded on Mars [5,6,7], and lunar 'flashes' (likely impacts) observed by teams such as those at Marshall Space Flight Center [8]. Since July of 2009, the Lunar Reconnaissance Orbiter Camera (LROC) collects meter scale Narrow Angle Camera (NAC) images, with repeat coverage in areas of high interest. Planned and serendipitous re-imaging with similar illumination conditions provides the means to detect temporal surface changes with the ultimate goal of measuring the current flux of impacts on the Moon. To easily detect a change at the surface, NAC-pairs separated in time (temporal pair), with similar illumination geometries are compared. Overlapping regions in a temporal pair are map projected and co-registered and a ratio is computed (second observation / first observation) and examined for temporal anomalies. Some changes are clearly distinguished as newly formed craters with rims and ejecta, while others are simply small (a few pixels) reflectance changes (crater not resolved). Detections are categorized as relatively high reflectance changes (HRC) or low reflectance changes (LRC) relative to the surrounding substrate. To date the LRCs outnumber the HRCs by a factor of ten. Clusters (>3) of changes were discovered in 48 temporal pairs. So far, we have identified 599 individual changes, with 547 LRCs and 48 HRCs. Of the 599 detections, sixteen represent resolved craters, and of these diameters range up to 20 m, suggesting bolide sizes up to ~1 m diameter. The total surface area examined to date is ~25,000 square km and the maximum time window between repeat images is 2.5 years, yielding an estimated minimum 364,000 new lunar craters per year (or one crater per year for every 104 square km) detectable at the scale

  5. Leonardo da Vinci and the Downburst.

    NASA Astrophysics Data System (ADS)

    Gedzelman, Stanley David

    1990-05-01

    Evidence from the drawings, experiments, and writings of Leonardo da Vinci are presented to demonstrate that da Vinci recognized and, possibly, discovered the downburst and understood its associated airflow. Other early references to vortex flows resembling downbursts are mentioned.

  6. Ultrasound-enhanced transdermal delivery: recent advances and future challenges

    PubMed Central

    Oberli, Matthias A; Schoellhammer, Carl M; Langer, Robert; Blankschtein, Daniel

    2016-01-01

    The skin is a formidable diffusion barrier that restricts passive diffusion to small (<500 Da) lipophilic molecules. Methods used to permeabilize this barrier for the purpose of drug delivery are maturing as an alternative to oral drug delivery and hypodermic injections. Ultrasound can reversibly and non-invasively permeabilize the diffusion barrier posed by the skin. This review discusses the mechanisms of ultrasound-permeability enhancement, and presents technological innovations in equipment miniaturization and recent advances in permeabilization capabilities. Additionally, potentially exciting applications, including protein delivery, vaccination, gene therapy and sensing of blood analytes, are discussed. Finally, the future challenges and opportunities associated with the use of ultrasound are discussed. It is stressed that developing ultrasound for suitable applications is key to ensure commercial success. PMID:25287389

  7. Discussions about the Nature of Science in a Course on the History of Astronomy. (Spanish Title: Discusiones sobre la Naturaleza de la Ciencia en un Curso sobre Historia de la Astronomía.) Discussões sobre a Natureza da Ciência em um Curso sobre a História da Astronomia

    NASA Astrophysics Data System (ADS)

    Pires de Andrade, Victória Flório; L'Astorina, Bruno

    2010-07-01

    There are an increasing number of researches in science education that affirm the importance of discussions on the "nature of science" in basic education level as well as in teacher training. The history of science applied to education is a way to contextualize epistemological discussions, allowing both the understanding of scientific content and learning about science concepts. We present some reasonably consensual definitions on the nature of science that have been widely discussed by the academic community. We show also some episodes in the history of astronomy which can lead to discussions involving some aspects of the nature of science, and how they can do it. Hay un número creciente de investigaciones en la enseñanza de las ciencias que afirman la importancia de debates sobre la "naturaleza de la ciencia" en la educación básica y formación del profesorado. La historia de la ciencia aplicada a la educación es una manera de contextualizar los debates de la epistemología, lo que permite tanto la comprensión de los contenidos científicos como el aprendizaje de conceptos científicos. En esto trabajo, presentamos algunas definiciones bastante consensuales sobre la naturaleza de la ciencia que han sido ampliamente discutidas por la comunidad académica y mostramos cómo algunos episodios en la historia de la astronomía pueden llevar a discusiones sobre algunos aspectos de la naturaleza de la ciencia. Há um número crescente de pesquisas na área de ensino de ciências que afirmam a importância de discussões sobre a "natureza da ciência" na educação básica e na formação de professores. A história da ciência aplicada ao ensino é uma maneira de contextualizar discussões epistemológicas, permitindo tanto a compreensão de conteúdos científicos quanto o aprendizado de noções sobre as ciências. Neste trabalho apresentamos algumas definições razoavelmente consensuais sobre a natureza da ciência que foram amplamente discutidas pela

  8. The rare DAT coding variant Val559 perturbs DA neuron function, changes behavior, and alters in vivo responses to psychostimulants

    PubMed Central

    Mergy, Marc A.; Gowrishankar, Raajaram; Gresch, Paul J.; Gantz, Stephanie C.; Williams, John; Davis, Gwynne L.; Wheeler, C. Austin; Stanwood, Gregg D.; Hahn, Maureen K.; Blakely, Randy D.

    2014-01-01

    Despite the critical role of the presynaptic dopamine (DA) transporter (DAT, SLC6A3) in DA clearance and psychostimulant responses, evidence that DAT dysfunction supports risk for mental illness is indirect. Recently, we identified a rare, nonsynonymous Slc6a3 variant that produces the DAT substitution Ala559Val in two male siblings who share a diagnosis of attention-deficit hyperactivity disorder (ADHD), with other studies identifying the variant in subjects with bipolar disorder (BPD) and autism spectrum disorder (ASD). Previously, using transfected cell studies, we observed that although DAT Val559 displays normal total and surface DAT protein levels, and normal DA recognition and uptake, the variant transporter exhibits anomalous DA efflux (ADE) and lacks capacity for amphetamine (AMPH)-stimulated DA release. To pursue the significance of these findings in vivo, we engineered DAT Val559 knock-in mice, and here we demonstrate in this model the presence of elevated extracellular DA levels, altered somatodendritic and presynaptic D2 DA receptor (D2R) function, a blunted ability of DA terminals to support depolarization and AMPH-evoked DA release, and disruptions in basal and psychostimulant-evoked locomotor behavior. Together, our studies demonstrate an in vivo functional impact of the DAT Val559 variant, providing support for the ability of DAT dysfunction to impact risk for mental illness. PMID:25331903

  9. The rare DAT coding variant Val559 perturbs DA neuron function, changes behavior, and alters in vivo responses to psychostimulants.

    PubMed

    Mergy, Marc A; Gowrishankar, Raajaram; Gresch, Paul J; Gantz, Stephanie C; Williams, John; Davis, Gwynne L; Wheeler, C Austin; Stanwood, Gregg D; Hahn, Maureen K; Blakely, Randy D

    2014-11-01

    Despite the critical role of the presynaptic dopamine (DA) transporter (DAT, SLC6A3) in DA clearance and psychostimulant responses, evidence that DAT dysfunction supports risk for mental illness is indirect. Recently, we identified a rare, nonsynonymous Slc6a3 variant that produces the DAT substitution Ala559Val in two male siblings who share a diagnosis of attention-deficit hyperactivity disorder (ADHD), with other studies identifying the variant in subjects with bipolar disorder (BPD) and autism spectrum disorder (ASD). Previously, using transfected cell studies, we observed that although DAT Val559 displays normal total and surface DAT protein levels, and normal DA recognition and uptake, the variant transporter exhibits anomalous DA efflux (ADE) and lacks capacity for amphetamine (AMPH)-stimulated DA release. To pursue the significance of these findings in vivo, we engineered DAT Val559 knock-in mice, and here we demonstrate in this model the presence of elevated extracellular DA levels, altered somatodendritic and presynaptic D2 DA receptor (D2R) function, a blunted ability of DA terminals to support depolarization and AMPH-evoked DA release, and disruptions in basal and psychostimulant-evoked locomotor behavior. Together, our studies demonstrate an in vivo functional impact of the DAT Val559 variant, providing support for the ability of DAT dysfunction to impact risk for mental illness. PMID:25331903

  10. Recent developments in the global geomagnetic observatory network

    NASA Astrophysics Data System (ADS)

    Chulliat, A.

    2011-12-01

    Magnetic observatories provide precise and continuous measurements of geomagnetic variations over time scales ranging from one second to more than a century. They have been an essential observational infrastructure for geomagnetic research for about 170 years. A large fraction of magnetic observatories belong to INTERMAGNET (International Real-time Magnetic Observatory Network), a global network founded in the late 1980s which now includes about 115 observatories in 45 countries. INTERMAGNET magnetic observatories comply with strict data quality and timeliness standards and distribute their data through an integrated data information system. Recent years have seen a rapid expansion of the global network: new observatories have been installed in remote locations, such as oceanic islands (St Helena, Easter Island, Tristan da Cunha) or Antarctica (Dome C); ancient observatories have been upgraded to international standards (for example in China and Siberia). This has been prompted by the need to have a more geographically homogeneous network. In parallel, new data products (one second data and quasi-definitive data) are being made available, addressing a wide variety of research needs, and real timeliness is being improved for operational purposes such as space weather monitoring and forecasting. This presentation will provide an overview of these recent developments, focusing on those most relevant to the geomagnetic modeling community, and discuss their expected scientific benefits.

  11. Fluorine substitution enhanced photovoltaic performance of a D-A(1)-D-A(2) copolymer.

    PubMed

    Dang, Dongfeng; Chen, Weichao; Yang, Renqiang; Zhu, Weiguo; Mammo, Wendimagegn; Wang, Ergang

    2013-10-18

    A new alternating donor-acceptor (D-A1-D-A2) copolymer containing two electron-deficient moieties, isoindigo and quinoxaline, was synthesized. The photovoltaic performance of this polymer could be improved by incorporating fluorine atoms into the quinoxaline units, resulting in an efficiency of 6.32%. This result highlights the attractive promise of D-A1-D-A2 copolymers for high-performance bulk heterojunction solar cells. PMID:24000353

  12. Some Recent Progress for Approximation Algorithms

    NASA Astrophysics Data System (ADS)

    Kawarabayashi, Ken-ichi

    We survey some recent progress on approximation algorithms. Our main focus is the following two problems that have some recent breakthroughs; the edge-disjoint paths problem and the graph coloring problem. These breakthroughs involve the following three ingredients that are quite central in approximation algorithms: (1) Combinatorial (graph theoretical) approach, (2) LP based approach and (3) Semi-definite programming approach. We also sketch how they are used to obtain recent development.

  13. Recent Trends and Advances in Sedimentology.

    ERIC Educational Resources Information Center

    Suttner, Lee J.

    1979-01-01

    Briefly surveys recent trends and developments in sedimentology. Includes Clastic sedimentary petrology, petrology of argillaceous rocks, terrigenous depositional environments, and chemical sedimentology. (MA)

  14. In response to Dr. Jose AP da Silva: fall prevention with vitamin D clarifications needed

    Technology Transfer Automated Retrieval System (TEKTRAN)

    We agree with Dr. da Silva, and wish to clarify three issues raised by the recent IOM report concerning our 2009 meta-analysis on vitamin D and fall prevention. 1. The IOM questioned the inclusion of Broe et al., which did not pre-specify falls as a primary or secondary outcome. While this did viol...

  15. The ATLAS PanDA Pilot in Operation

    NASA Astrophysics Data System (ADS)

    Nilsson, P.; Caballero, J.; De, K.; Maeno, T.; Stradling, A.; Wenaus, T.; ATLAS Collaboration

    2011-12-01

    The Production and Distributed Analysis system (PanDA) [1-2] was designed to meet ATLAS [3] requirements for a data-driven workload management system capable of operating at LHC data processing scale. Submitted jobs are executed on worker nodes by pilot jobs sent to the grid sites by pilot factories. This paper provides an overview of the PanDA pilot [4] system and presents major features added in light of recent operational experience, including multi-job processing, advanced job recovery for jobs with output storage failures, gLExec [5-6] based identity switching from the generic pilot to the actual user, and other security measures. The PanDA system serves all ATLAS distributed processing and is the primary system for distributed analysis; it is currently used at over 100 sites worldwide. We analyze the performance of the pilot system in processing real LHC data on the OSG [7], EGI [8] and Nordugrid [9-10] infrastructures used by ATLAS, and describe plans for its evolution.

  16. OpenDA-NEMO framework for ocean data assimilation

    NASA Astrophysics Data System (ADS)

    van Velzen, Nils; Altaf, Muhammad Umer; Verlaan, Martin

    2016-03-01

    Data assimilation methods provide a means to handle the modeling errors and uncertainties in sophisticated ocean models. In this study, we have created an OpenDA-NEMO framework unlocking the data assimilation tools available in OpenDA for use with NEMO models. This includes data assimilation methods, automatic parallelization, and a recently implemented automatic localization algorithm that removes spurious correlations in the model based on uncertainties in the computed Kalman gain matrix. We have set up a twin experiment where we assimilate sea surface height (SSH) satellite measurements. From the experiments, we can conclude that the OpenDA-NEMO framework performs as expected and that the automatic localization significantly improves the performance of the data assimilation algorithm by successfully removing spurious correlations. Based on these results, it looks promising to extend the framework with new kinds of observations and work on improving the computational speed of the automatic localization technique such that it becomes feasible to include large number of observations.

  17. Amelioration of Auditory Response by DA9801 in Diabetic Mouse

    PubMed Central

    Hong, Bin Na; Her, You Ri; Castañeda, Rodrigo; Moon, Hyo Won

    2015-01-01

    Diabetes mellitus (DM) is a metabolic disease that involves disorders such as diabetic retinopathy, diabetic neuropathy, and diabetic hearing loss. Recently, neurotrophin has become a treatment target that has shown to be an attractive alternative in recovering auditory function altered by DM. The aim of this study was to evaluate the effect of DA9801, a mixture of Dioscorea nipponica and Dioscorea japonica extracts, in the auditory function damage produced in a STZ-induced diabetic model and to provide evidence of the mechanisms involved in enhancing these protective effects. We found a potential application of DA9801 on hearing impairment in the STZ-induced diabetic model, demonstrated by reducing the deterioration produced by DM in ABR threshold in response to clicks and normalizing wave I–IV latencies and Pa latencies in AMLR. We also show evidence that these effects might be elicited by inducing NGF related through Nr3c1 and Akt. Therefore, this result suggests that the neuroprotective effects of DA9801 on the auditory damage produced by DM may be affected by NGF increase resulting from Nr3c1 via Akt transformation. PMID:25878713

  18. Amelioration of Auditory Response by DA9801 in Diabetic Mouse.

    PubMed

    Lee, Yeong Ro; Hong, Bin Na; Her, You Ri; Castañeda, Rodrigo; Moon, Hyo Won; Kang, Tong Ho

    2015-01-01

    Diabetes mellitus (DM) is a metabolic disease that involves disorders such as diabetic retinopathy, diabetic neuropathy, and diabetic hearing loss. Recently, neurotrophin has become a treatment target that has shown to be an attractive alternative in recovering auditory function altered by DM. The aim of this study was to evaluate the effect of DA9801, a mixture of Dioscorea nipponica and Dioscorea japonica extracts, in the auditory function damage produced in a STZ-induced diabetic model and to provide evidence of the mechanisms involved in enhancing these protective effects. We found a potential application of DA9801 on hearing impairment in the STZ-induced diabetic model, demonstrated by reducing the deterioration produced by DM in ABR threshold in response to clicks and normalizing wave I-IV latencies and Pa latencies in AMLR. We also show evidence that these effects might be elicited by inducing NGF related through Nr3c1 and Akt. Therefore, this result suggests that the neuroprotective effects of DA9801 on the auditory damage produced by DM may be affected by NGF increase resulting from Nr3c1 via Akt transformation. PMID:25878713

  19. OpenDA-NEMO framework for ocean data assimilation

    NASA Astrophysics Data System (ADS)

    van Velzen, Nils; Altaf, Muhammad Umer; Verlaan, Martin

    2016-05-01

    Data assimilation methods provide a means to handle the modeling errors and uncertainties in sophisticated ocean models. In this study, we have created an OpenDA-NEMO framework unlocking the data assimilation tools available in OpenDA for use with NEMO models. This includes data assimilation methods, automatic parallelization, and a recently implemented automatic localization algorithm that removes spurious correlations in the model based on uncertainties in the computed Kalman gain matrix. We have set up a twin experiment where we assimilate sea surface height (SSH) satellite measurements. From the experiments, we can conclude that the OpenDA-NEMO framework performs as expected and that the automatic localization significantly improves the performance of the data assimilation algorithm by successfully removing spurious correlations. Based on these results, it looks promising to extend the framework with new kinds of observations and work on improving the computational speed of the automatic localization technique such that it becomes feasible to include large number of observations.

  20. Soviet Cybernetics: Recent News Items, Number Thirteen.

    ERIC Educational Resources Information Center

    Holland, Wade B.

    An issue of "Soviet Cybernetics: Recent News Items" consists of English translations of the leading recent Soviet contributions to the study of cybernetics. Articles deal with cybernetics in the 21st Century; the Soviet State Committee on Science and Technology; economic reforms in Rudnev's ministry; an interview with Rudnev; Dnepr-2; Dnepr-2…

  1. Recent developments in four-dimensional supergravity

    NASA Astrophysics Data System (ADS)

    Sharpe, Eric

    2011-10-01

    I will summarize recent work on gauge theories in supergravity, specifically concerning the `Fayet-Iliopoulos' parameter. In rigidly supersymmetric gauge theories, this parameter also appears and can vary continuously. In supergravity old lore held that it should always vanish. I will discuss recent developments showing that in fact it can be nonzero, but is quantized, and will explore various ramifications of that result.

  2. A Bibliography of Recent Alcohol Research.

    ERIC Educational Resources Information Center

    Buckalew, L. W.

    This compilation of bibliographic citations consists of approximately 70 recent alcohol research references, categorized topically. These post-1972 references are offered in order to reduce the communication problem between the public and the scientific community by informing researchers about the most recent and available alcohol knowledge and…

  3. Recent Advances in Studies of Current Noise

    NASA Astrophysics Data System (ADS)

    Blanter, Yaroslav M.

    This is a brief review of recent activities in the field of current noise intended for newcomers. We first briefly discuss main properties of shot noise in nanostructures, and then turn to recent developments, concentrating on issues related to experimental progress: non-symmetrized cumulants and quantum noise; counting statistics; super-Poissonian noise; current noise and interferometry

  4. Recent trends in particle size analysis techniques

    NASA Technical Reports Server (NTRS)

    Kang, S. H.

    1984-01-01

    Recent advances and developments in the particle-sizing technologies are briefly reviewed in accordance with three operating principles including particle size and shape descriptions. Significant trends of the particle size analysing equipment recently developed show that compact electronic circuitry and rapid data processing systems were mainly adopted in the instrument design. Some newly developed techniques characterizing the particulate system were also introduced.

  5. Evaluative Conditioning: Recent Developments and Future Directions

    ERIC Educational Resources Information Center

    Gast, Anne; Gawronski, Bertram; De Houwer, Jan

    2012-01-01

    Evaluative conditioning (EC) is generally considered to be one of the routes via which likes and dislikes are acquired. We identify recent trends in EC research and speculate about the topics that will dominate future research on EC. Many of the recent developments in EC research were shaped by functional definitions of EC that refer only to…

  6. Autocorrelation descriptor improvements for QSAR: 2DA_Sign and 3DA_Sign.

    PubMed

    Sliwoski, Gregory; Mendenhall, Jeffrey; Meiler, Jens

    2016-03-01

    Quantitative structure-activity relationship (QSAR) is a branch of computer aided drug discovery that relates chemical structures to biological activity. Two well established and related QSAR descriptors are two- and three-dimensional autocorrelation (2DA and 3DA). These descriptors encode the relative position of atoms or atom properties by calculating the separation between atom pairs in terms of number of bonds (2DA) or Euclidean distance (3DA). The sums of all values computed for a given small molecule are collected in a histogram. Atom properties can be added with a coefficient that is the product of atom properties for each pair. This procedure can lead to information loss when signed atom properties are considered such as partial charge. For example, the product of two positive charges is indistinguishable from the product of two equivalent negative charges. In this paper, we present variations of 2DA and 3DA called 2DA_Sign and 3DA_Sign that avoid information loss by splitting unique sign pairs into individual histograms. We evaluate these variations with models trained on nine datasets spanning a range of drug target classes. Both 2DA_Sign and 3DA_Sign significantly increase model performance across all datasets when compared with traditional 2DA and 3DA. Lastly, we find that limiting 3DA_Sign to maximum atom pair distances of 6 Å instead of 12 Å further increases model performance, suggesting that conformational flexibility may hinder performance with longer 3DA descriptors. Consistent with this finding, limiting the number of bonds in 2DA_Sign from 11 to 5 fails to improve performance. PMID:26721261

  7. Nanoelectrodes: Recent Advances and New Directions

    NASA Astrophysics Data System (ADS)

    Cox, Jonathan T.; Zhang, Bo

    2012-07-01

    This article reviews recent work involving the development and application of nanoelectrodes in electrochemistry and related areas. We first discuss common analytical methods for characterizing the size, shape, and quality of nanoelectrodes, including electron microscopy, steady-state cyclic voltammetry, scanning electrochemical microscopy, and surface modification. We then emphasize recent developments in fabrication techniques that have led to structurally well-defined nanoelectrodes. We highlight recent advances in the application of nanoelectrodes in important analytical chemistry areas, such as single-molecule studies, single-nanoparticle electrochemistry, and measurements of neurotransmitters from single neuronal cells.

  8. Recent advances in graphene-based biosensors.

    PubMed

    Kuila, Tapas; Bose, Saswata; Khanra, Partha; Mishra, Ananta Kumar; Kim, Nam Hoon; Lee, Joong Hee

    2011-08-15

    A detailed overview towards the advancement of graphene based biosensors has been reviewed. The large surface area and excellent electrical conductivity of graphene allow it to act as an "electron wire" between the redox centers of an enzyme or protein and an electrode's surface. Rapid electron transfer facilitates accurate and selective detection of biomolecules. This review discusses the application of graphene for the detection of glucose, Cyt-c, NADH, Hb, cholesterol, AA, UA, DA, and H(2)O(2). GO and RGO have been used for the fabrication of heavy metal ion sensors, gas sensors, and DNA sensors. Graphene based FETs have also been discussed in details. In all these cases, the biosensors performed well with low working potentials, high sensitivities, low detection limits, and long-term stabilities. PMID:21683572

  9. Recent Supreme Court decisions and licensing power.

    PubMed

    Giordano-Coltart, Jennifer; Calkins, Charles W

    2008-02-01

    The recently decided eBay and MedImmune cases interject both reassurance and uncertainty into the present patent licensing landscape, affecting the strategic decisions to be considered during negotiations. PMID:18259170

  10. Recent QCD results from the Tevatron

    SciTech Connect

    Pickarz, Henryk; CDF and DO collaboration

    1997-02-01

    Recent QCD results from the CDF and D0 detectors at the Tevatron proton-antiproton collider are presented. An outlook for future QCD tests at the Tevatron collider is also breifly discussed. 27 refs., 11 figs.

  11. Recent Developments in Radioastronomy--Part 2.

    ERIC Educational Resources Information Center

    Booth, R. S.

    1980-01-01

    Described are recent developments and discoveries in radioastronomy. Topics discussed include galactic structures, stellar evolution, the binary pulsar and general relativity, extragalactic radioastronomy, model of the source of radioactive emission and quasars. (DS)

  12. Jefferson Lab physics overview: Recent results

    SciTech Connect

    Meziani, Zein-Eddine

    2007-09-01

    I review highlights of the Jefferson Lab nucleon structure program. I shall emphasize recent results from experiments exploring the spin structure of the nucleon and from dedicated experiments aimed at accessing the generalized parton distributions (GPDs).

  13. Recent results on hadron structure from COMPASS

    NASA Astrophysics Data System (ADS)

    Makke, Nour

    2016-05-01

    A review of the most recent measurements of longitudinal and transverse momentum dependent distributions and fragmentation functions accessed in the inclusive and the semi-inclusive deep inelastic scattering from COMPASS is given.

  14. Recent Developments in Empirical Industrial Organization.

    ERIC Educational Resources Information Center

    Porter, Robert H.

    1994-01-01

    Presents an bibliographic essay of recent empirical research in industrial organization. Examines topics such as the econometrics of markets with imperfect competition, technology and industry structure, industry evolution, and industry studies of regulation. (CFR)

  15. Recent Chinese Innovations in Teacher Education.

    ERIC Educational Resources Information Center

    Ren-Mei, Tan; And Others

    1985-01-01

    Before 1949, education was largely ignored in China, but recently it has been given a priority almost equal to modern industrialization. Teacher education reforms have been extensive and varied. These reforms are described, and further challenges are outlined. (MT)

  16. Recent Refrigeration Cycle Technologies for Household Refrigerators

    NASA Astrophysics Data System (ADS)

    Nagatomo, Shigemi

    The household refrigerator is one of the most important and the biggest energy-consuming home appliances. This paper summarize recent refrigeration cycle developments in the field of domestic household refrigerators based on a survey of publications.

  17. Recent Events in Guidance, Navigation and Control

    NASA Technical Reports Server (NTRS)

    Polites, Michael E.; Bullman, Jack (Technical Monitor)

    2001-01-01

    This article summarizes recent events in Guidance, Navigation, and Control (GN&C) in space, weapons and missiles, and aircraft. The section on space includes recent developments with the following NASA spacecraft and space vehicles: Near Earth Asteroid Rendezvous, Deep Space 1, Microwave Anisotropy Probe, Earth Observer-1, Compton Gamma Ray Observatory, the International Space Station, X-38, and X-40A. The section on weapons and missiles includes recent developments with the following missiles: Joint Air-to-Surface Standoff Missile, Storm Shadow/Scalp EG precision standoff missile, Hellfire missile, AIM-120C Advanced medium-range air-to-air missile, Derby missile, Arrow 2, and the Standard Missile SM-3. The section on aircraft includes recent developments with the following aircraft: Joint Strike Fighter, X-31, V-22, Couger/SUDer Puma Mk. 2, Predator B 001, and the Unmanned Combat Air Vehicle.

  18. Symposium on Recent Results in Infrared Astrophysics

    NASA Technical Reports Server (NTRS)

    Dyal, P. (Editor)

    1977-01-01

    Abstracts of papers presented at a symposium titled Recent Results in Infrared Astrophysics are set forth. The abstracts emphasize photometric, spectroscopic, polarization, and theoretical results on a broad range of current topics in infrared astrophysics.

  19. Preface: Recent Advances in Fractional Dynamics.

    PubMed

    Srivastava, H M; Baleanu, Dumitru; Li, Changpin

    2016-08-01

    This Special Focus Issue contains several recent developments and advances on the subject of Fractional Dynamics and its widespread applications in various areas of the mathematical, physical, and engineering sciences. PMID:27586617

  20. Some Recent Advances in Plant Physiology

    ERIC Educational Resources Information Center

    Stafford, G. A.

    1972-01-01

    A popular review of plant physiological research, emphasizing those apsects of plant metabolism where there has been a recent shift in emphasis that is not yet reflected in secondary school advanced texts. (AL)

  1. Recent progress in polymer optical fibre gratings

    NASA Astrophysics Data System (ADS)

    Zhang, C.; Carroll, K.; Webb, D. J.; Bennion, I.; Kalli, K.; Emiliyanov, G.; Bang, O.; Kjær, E.; Peng, G. D.

    2008-04-01

    We describe our recent progress in polymer fibre Bragg grating technology, including the writing of the first FBGs in TOPAS cyclic olefin copolymer, enhancements to photosensitivity brought about by dopants and studies on grating annealing.

  2. Highlights of Recent Results with Clas

    SciTech Connect

    Volker Burkert

    2005-04-01

    Recent results on the study of the electromagnetic structure of nucleon resonances, the spin structure of proton and neutrons at small and intermediate photon virtualities, and the search for exotic pentaquark baryons are presented.

  3. Recent Tests for the Statistical Parton Distributions

    NASA Astrophysics Data System (ADS)

    Bourrely, Claude; Soffer, Jacques; Buccella, Franco

    We compare some recent experimental results obtained at DESY, SLAC and Jefferson Lab., with the predictions of the statistical model, we have previously proposed. The result of this comparison is very satisfactory.

  4. Recent Results from the MAGIC Telescope

    SciTech Connect

    Bock, Rudolf K.

    2005-02-21

    Some recent results are shown, obtained during the commissioning period of the MAGIC telescope. They demonstrate that the telescope is now approaching a performance level suitable for physics observations.

  5. Recent lattice QCD results on nucleon structure

    SciTech Connect

    Konstantinos Orginos

    2006-07-01

    I review recent developments in lattice calculations of nucleon structure. In particular, I cover the calculations of nucleon matrix elements related to generalized parton distribution functions, structure functions and form factors.

  6. Lipids of aquatic sediments, recent and ancient

    NASA Technical Reports Server (NTRS)

    Eglinton, G.; Hajibrahim, S. K.; Maxwell, J. R.; Quirke, J. M. E.; Shaw, G. J.; Volkman, J. K.; Wardroper, A. M. K.

    1979-01-01

    Computerized gas chromatography-mass spectrometry (GC-MS) is now an essential tool in the analysis of the complex mixtures of lipids (geolipids) encountered in aquatic sediments, both 'recent' (less than 1 million years old) and ancient. The application of MS, and particularly GC-MS, has been instrumental in the rapid development of organic geochemistry and environmental organic chemistry in recent years. The techniques used have resulted in the identification of numerous compounds of a variety of types in sediments. Most attention has been concentrated on molecules of limited size, mainly below 500 molecular mass, and of limited functionality, for examples, hydrocarbons, fatty acids and alcohols. Examples from recent studies (at Bristol) of contemporary, 'recent' and ancient sediments are presented and discussed.

  7. Recent Developments in DAO's Finite-Volume Data Assimilation System

    NASA Technical Reports Server (NTRS)

    daSilva, Arlindo; Lin, S.-J.; Joiner, J.; Dee, D.; Frank, D.; Norris, P.; Poli, P.; Atlas, Robert (Technical Monitor)

    2001-01-01

    The Physical-space/Finite-volume Data Assimilation System (fvDAS) is the next generation global atmospheric data assimilation system in development at the Data Assimilation Office at NASA's Goddard Space Flight Center. It is based on a new finite-volume general circulation model jointly developed by NASA and NCAR and on the Physical-Space Statistical Analysis System (PSAS) developed at the DAO. The data assimilation method implemented in CODAS incorporates a simplified version of the model bias estimation and correction algorithm, as described by Dee and da Silva (1998). In this talk we will briefly describe the general system formulation, and focus on the impact of 3 data types recently introduced, namely: 1) cloud tracks winds from the Multi-angle Imaging Spectrometer by the US Air Force, and 3) temperature and moisture information derived from GPS refractivity occultation measurements. The impact of these data types on observation-minus-6hr forecast (O-F) statistics, as well as 5-day forecast skills will be discussed. In addition we will assess the impact of cloud assimilation on top of the atmosphere radiation fields estimated from CERES measurements.

  8. Recent results on baryon production at PETRA

    SciTech Connect

    Wu, S.L.

    1982-01-01

    One of the recent excitements at PETRA is the observation of the copious production of baryons. About a year ago, TASSO observed the inclusive production of protons and antiprotons. More recently JADE confirmed the inclusive antiproton spectrum to about 1 GeV/c and also observed the inclusive anti ..lambda.. spectrum to about 1.4 GeV/c, while TASSO obtained the ..lambda.. and anti-..lambda.. spectrum all the way up 10 GeV/c in momentum.

  9. Recent Advances in Combined Modality Therapy

    PubMed Central

    Nyati, Mukesh K.; Morgan, Meredith A.; Lawrence, Theodore S.

    2010-01-01

    Combined modality therapy emerged from preclinical data showing that carefully chosen drugs could enhance the sensitivity of tumor cells to radiation while having nonoverlapping toxicities. Recent advances in molecular biology involving the identification of cellular receptors, enzymes, and pathways involved in tumor growth and immortality have resulted in the development of biologically targeted drugs. This review highlights the recent clinical data in support of newer generation cytotoxic chemotherapies and systemic targeted agents in combination with radiation therapy. PMID:20413642

  10. Recent developments in HLA-haploidentical transplantations

    PubMed Central

    Showel, Margaret; Fuchs, Ephraim J.

    2016-01-01

    While allogeneic hematopoietic stem cell transplantations have a curative potential, several patients with hematologic malignancies cannot avail themselves of this therapeutic option due to lack of matched donor availability. Although HLA-haploidentical transplantations were previously associated with poor outcomes, recent evidence with use of post transplantation cyclophosphamide indicate improved safety and efficacy. The following paper discusses the most recent developments in this area. PMID:26590771

  11. Detecção da fase impulsiva de uma explosão solar gigante até 405 GHz

    NASA Astrophysics Data System (ADS)

    Raulin, J.-P.; Makhmutov, V.; Kaufmann, P.; Pacini, A. A.; Luethi, T.; Hudson, H. S.; Gary, D. E.; Yoshimori, M.

    2003-08-01

    A explosão ocorrida no dia 25/08/2001 foi uma das mais intensas do presente ciclo solar em ondas de rádio de altas frequências. Foram medidas em ondas milimétricas e submilimétricas, aproximadamente, 105 e vários milhares de unidades de fluxo solar, respectivamente. Apresentamos um estudo deste evento em múltiplas frequências, desde microondas (1GHz), até ondas submilimétricas (405 GHz) detectadas pelo Telescópio Solar para ondas Submilimétricas (SST). Esta base de dados foi complementada utilizando-se o experimento Yohkoh, incluindo a emissão em raios-X duros e raios-g (até 100 MeV), e imagens em raios-X moles da região ativa envolvida. Enfocamos e discutimos principalmente os seguintes aspectos da fase impulsiva do evento: (i) as implicações deduzidas do espectro eletromagnético, obtido pela primeira vez até 405 GHz; (ii) a dinâmica da região ativa. Os resultados mostram que para explicar o espectro rádio observado, são necessários entre 3.5×1037 e 1.5×1039 elétrons acelerados acima de 20 keV em uma região de campo magnético entre 300 e 800 Gauss. A estimativa do fluxo de fótons que seria produzido por estes elétrons, mostra que grande parte deles não precipitou na baixa atmosfera. A evolução temporal da emissão em raios-X moles revela que a configuração magnética da região ativa foi muito dinâmica durante a fase impulsiva da explosão. Em particular, mostramos que a produção dos elétrons altamente energéticos foi iniciada junto com a aparição, na baixa coroa solar, de um novo sistema compacto de estruturas magnéticas. Este fato sugere que os locais de aceleração estão localizados na baixa atmosfera do Sol, como resultado da interação entre o novo sistema compacto e o campo magnético ambiente da região ativa.

  12. Virtual observatory publishing with DaCHS

    NASA Astrophysics Data System (ADS)

    Demleitner, M.; Neves, M. C.; Rothmaier, F.; Wambsganss, J.

    2014-11-01

    The Data Center Helper Suite DaCHS is an integrated publication package for building VO and Web services, supporting the entire workflow from ingestion to data mapping to service definition. It implements all major data discovery, data access, and registry protocols defined by the VO. DaCHS in this sense works as glue between data produced by the data providers and the standard protocols and formats defined by the VO. This paper discusses central elements of the design of the package and gives two case studies of how VO protocols are implemented using DaCHS' concepts.

  13. Recent advances in vacuum sciences and applications

    NASA Astrophysics Data System (ADS)

    Mozetič, M.; Ostrikov, K.; Ruzic, D. N.; Curreli, D.; Cvelbar, U.; Vesel, A.; Primc, G.; Leisch, M.; Jousten, K.; Malyshev, O. B.; Hendricks, J. H.; Kövér, L.; Tagliaferro, A.; Conde, O.; Silvestre, A. J.; Giapintzakis, J.; Buljan, M.; Radić, N.; Dražić, G.; Bernstorff, S.; Biederman, H.; Kylián, O.; Hanuš, J.; Miloševič, S.; Galtayries, A.; Dietrich, P.; Unger, W.; Lehocky, M.; Sedlarik, V.; Stana-Kleinschek, K.; Drmota-Petrič, A.; Pireaux, J. J.; Rogers, J. W.; Anderle, M.

    2014-04-01

    Recent advances in vacuum sciences and applications are reviewed. Novel optical interferometer cavity devices enable pressure measurements with ppm accuracy. The innovative dynamic vacuum standard allows for pressure measurements with temporal resolution of 2 ms. Vacuum issues in the construction of huge ultra-high vacuum devices worldwide are reviewed. Recent advances in surface science and thin films include new phenomena observed in electron transport near solid surfaces as well as novel results on the properties of carbon nanomaterials. Precise techniques for surface and thin-film characterization have been applied in the conservation technology of cultural heritage objects and recent advances in the characterization of biointerfaces are presented. The combination of various vacuum and atmospheric-pressure techniques enables an insight into the complex phenomena of protein and other biomolecule conformations on solid surfaces. Studying these phenomena at solid-liquid interfaces is regarded as the main issue in the development of alternative techniques for drug delivery, tissue engineering and thus the development of innovative techniques for curing cancer and cardiovascular diseases. A review on recent advances in plasma medicine is presented as well as novel hypotheses on cell apoptosis upon treatment with gaseous plasma. Finally, recent advances in plasma nanoscience are illustrated with several examples and a roadmap for future activities is presented.

  14. Recent developments in paediatric neuraxial blocks

    PubMed Central

    Ponde, Vrushali Chandrashekhar

    2012-01-01

    Paediatric anaesthesia and paediatric regional anaesthesia are intertwined. Almost all surgeries unless contradicted could be and should be supplemented with a regional block. The main objective of this review is to elaborate on the recent advances of the central neuraxial blocks, such as application of ultrasound guidance and electrical stimulation in the pursuit of safety and an objective end point. This review also takes account of the traditional technique and understand the benefits as well the risk of each as compared with the recent technique. The recent trends in choosing the most appropriate peripheral block for a given surgery thereby sparing the central neuroaxis is considered. A penile block for circumcision or a sciatic block for unilateral foot surgery, rather than caudal epidural would have a better risk benefit equation. Readers will find a special mention on the recent thoughts on continuous epidural analgesia in paediatrics, especially its rise and fall, yet its unique importance. Lastly, the issue of block placements under sedation or general anaesthesia with its implication in this special population is dealt with. We conducted searches in MEDLINE (PubMed) and assessed the relevance of the abstracts of citations identified from literature searches. The search was carried out in English, for last 10 years, with the following key words: Recent advances in paediatric regional anaesthesia; ultrasound guidance for central neuraxial blocks in children; role of electrical stimulation in neuraxial blocks in children; complications in neuraxial block. Full-text articles of potentially relevant abstracts were retrieved for further review. PMID:23293386

  15. Projeto educação em ciências com observatórios virtuais: a participação da Escola Moppe no período 2000-2003

    NASA Astrophysics Data System (ADS)

    Wuensche, C. A.; Gavioli, E.; Oliveira, A. L. P. R. S.; da Silva, C.; Cardoso, H. P.; Estácio, S.

    2003-08-01

    O projeto Educação em Ciências com Observatórios Virtuais foi concebido pelo Instituto Astronômico e Geofísico da USP, agregando diversas instituições de ensino e pesquisa no país para desenvolver competências diversas na educação fundamental, média e superior utilizando a astronomia como ferramenta multidisciplinar. Este trabalho descreve a participação da MOPPE, escola-piloto do INPE no projeto, no período de 2000-2003. Serão apresentadas 1) a criação de um clube de ciências (1999 a 2001) cujo tema foi a colonização de Marte e 2) a ementa de astronomia trabalhada com as 7a. e 8a. séries do ensino fundamental. A proposta do projeto Colonizando Marte foi estudar diversos aspectos de uma missão interplanetária e construir experiementos que permitissem quantificar esses aspectos. Os resultados obtidos incluiram apresentações nas SBPC Jovem em 2000 e 2001. Discutiremos também as ementas de astronomia trabalhadas desde 2001 e o envolvimento dos alunos com atividades ligadas a astronomia, fora da aula de ciências. A inclusão de astronomia no currículo das últimas séries motivou a participação de mais alunos culminando com a conquista de duas medalhas para alunos da 7a. série na Olimpiada Brasileira de Astronomia em 2002. Houve também um aumento no número de participantes na OBA 2003 e nos projetos de astronomia mais elaborados nas Feira de Ciências de 2001 e 2002. Destacamos em 2003 a inclusão da MOPPE no projeto TIE - Telescopes in Education - da NASA, que utiliza o telescópio do Observatório de Mount Wilson (EUA) para observações remotas em projetos pedagógicos para o ensino de astronomia.

  16. Recent developments in structural sensitivity analysis

    NASA Technical Reports Server (NTRS)

    Haftka, Raphael T.; Adelman, Howard M.

    1988-01-01

    Recent developments are reviewed in two major areas of structural sensitivity analysis: sensitivity of static and transient response; and sensitivity of vibration and buckling eigenproblems. Recent developments from the standpoint of computational cost, accuracy, and ease of implementation are presented. In the area of static response, current interest is focused on sensitivity to shape variation and sensitivity of nonlinear response. Two general approaches are used for computing sensitivities: differentiation of the continuum equations followed by discretization, and the reverse approach of discretization followed by differentiation. It is shown that the choice of methods has important accuracy and implementation implications. In the area of eigenproblem sensitivity, there is a great deal of interest and significant progress in sensitivity of problems with repeated eigenvalues. In addition to reviewing recent contributions in this area, the paper raises the issue of differentiability and continuity associated with the occurrence of repeated eigenvalues.

  17. Recent advances and developments in refractory alloys

    SciTech Connect

    Nieh, T.G.; Wadsworth, J.

    1993-11-01

    Refractory metal alloys based on Mo, W, Re, Ta, and Nb (Cb) find applications in a wide range of aerospace applications because of their high melting points and high-temperature strength. This paper, presents recent progress in understanding and applications of these alloys. Recent studies to improve the oxidation and mechanical behavior of refractory metal alloys, and particularly Nb alloys, are also discussed. Some Re structures, for extremely high temperature applications (> 2000C), made by CVD and P/M processes, are also illustrated. Interesting work on the development of new W alloys (W-HfC-X) and the characterization of some commercial refractory metals, e.g., K-doped W, TZM, and Nb-1%Zr, continues. Finally, recent developments in high temperature composites reinforced with refractory metal filaments, and refractory metal-based intermetallics, e.g., Nb{sub 3}Al, Nb{sub 2}Be{sub 17}, and MoSi{sub 2}, are briefly described.

  18. Oklahoma's recent earthquakes and saltwater disposal.

    PubMed

    Walsh, F Rall; Zoback, Mark D

    2015-06-01

    Over the past 5 years, parts of Oklahoma have experienced marked increases in the number of small- to moderate-sized earthquakes. In three study areas that encompass the vast majority of the recent seismicity, we show that the increases in seismicity follow 5- to 10-fold increases in the rates of saltwater disposal. Adjacent areas where there has been relatively little saltwater disposal have had comparatively few recent earthquakes. In the areas of seismic activity, the saltwater disposal principally comes from "produced" water, saline pore water that is coproduced with oil and then injected into deeper sedimentary formations. These formations appear to be in hydraulic communication with potentially active faults in crystalline basement, where nearly all the earthquakes are occurring. Although most of the recent earthquakes have posed little danger to the public, the possibility of triggering damaging earthquakes on potentially active basement faults cannot be discounted. PMID:26601200

  19. Recent Advances in General Game Playing

    PubMed Central

    Świechowski, Maciej; Park, HyunSoo; Mańdziuk, Jacek; Kim, Kyung-Joong

    2015-01-01

    The goal of General Game Playing (GGP) has been to develop computer programs that can perform well across various game types. It is natural for human game players to transfer knowledge from games they already know how to play to other similar games. GGP research attempts to design systems that work well across different game types, including unknown new games. In this review, we present a survey of recent advances (2011 to 2014) in GGP for both traditional games and video games. It is notable that research on GGP has been expanding into modern video games. Monte-Carlo Tree Search and its enhancements have been the most influential techniques in GGP for both research domains. Additionally, international competitions have become important events that promote and increase GGP research. Recently, a video GGP competition was launched. In this survey, we review recent progress in the most challenging research areas of Artificial Intelligence (AI) related to universal game playing. PMID:26380375

  20. Aptamers in Virology: Recent Advances and Challenges

    PubMed Central

    Binning, Jennifer M.; Leung, Daisy W.; Amarasinghe, Gaya K.

    2012-01-01

    Aptamers generated from randomized libraries of nucleic acids have found utility in a wide variety of fields and in the clinic. Aptamers can be used to target both intracellular and extracellular components, including small molecules, proteins, cells, and viruses. With recent technological developments in stringent selection and rapid isolation strategies, it is likely that aptamers will continue to make an impact as useful tools and reagents. Although many recently developed aptamers are intended for use as therapeutic and diagnostic agents, use of aptamers for basic research, including target validation, remains an active area with high potential to impact our understanding of molecular mechanisms and for drug discovery. In this brief review, we will discuss recent aptamer discoveries, their potential role in structural virology, as well as challenges and future prospects. PMID:22347221

  1. Recent patents on electrophoretic displays and materials.

    PubMed

    Christophersen, Marc; Phlips, Bernard F

    2010-11-01

    Electrophoretic displays (EPDs) have made their way into consumer products. EPDs enable displays that offer the look and form of a printed page, often called "electronic paper". We will review recent apparatus and method patents for EPD devices and their fabrication. A brief introduction into the basic display operation and history of EPDs is given, while pointing out the technological challenges and difficulties for inventors. Recently, the majority of scientific publications and patenting activity has been directed to micro-segmented EPDs. These devices exhibit high optical reflectance and contrast, wide viewing angle, and high image resolution. Micro-segmented EPDs can also be integrated with flexible transistors technologies into flexible displays. Typical particles size ranges from 200 nm to 2 micrometer. Currently one very active area of patenting is the development of full-color EPDs. We summarize the recent patenting activity for EPDs and provide comments on perceiving factors driving intellectual property protection for EPD technologies. PMID:20565384

  2. Freeze Concentration and Its Recent Development

    NASA Astrophysics Data System (ADS)

    Wakisaka, Minato; Shirai, Yoshihito

    This article concerns freeze concentration and its recent development. Freeze concentration enables to remove water from aqueous solutions including volatile and heat-sensitive components with less damage to the concentrated solution because of the operation at lower temperature near the freezing point with possibly no gas-liquid boundary. Moreover, the lower latent heat accompanied with ice crystallization provides a possibility of the operation with lower energy consumption. Recently freeze concentration has been applied to the wastewater treatment field. First the principle of freeze concentration will be addressed. Second applications of freeze concentration to the wastewater treatment field will be reviewed, including our recent works. Finally prospective views of freeze concentration will be given.

  3. Hopf-Ranãda linked and knotted light beam solution viewed as a null electromagnetic field.

    PubMed

    Besieris, Ioannis M; Shaarawi, Amr M

    2009-12-15

    The Hopf-Ranãda linked and knotted light beam solution, which has been interpreted physically and extended analytically by Irvine and Bouwmeester recently, is viewed in this Letter as a null electromagnetic field. It is shown, in particular, that the Hopf-Ranãda solution is a variant of a luminal null electromagnetic wave due originally to Robinson and Troutman and reported by Bialynicki-Birula recently. This analogy is motivated by means of a method due to Whittaker and Bateman, and a relationship to well-known scalar luminal localized waves is examined. PMID:20016647

  4. Origin of the DA and non-DA white dwarf stars

    NASA Technical Reports Server (NTRS)

    Shipman, Harry L.

    1989-01-01

    Various proposals for the bifurcation of the white dwarf cooling sequence are reviewed. 'Primordial' theories, in which the basic bifurcation of the white dwarf sequence is rooted in events predating the white dwarf stage of stellar evolution, are discussed, along with the competing 'mixing' theories in which processes occurring during the white dwarf stage are responsible for the existence of DA or non-DA stars. A new proposal is suggested, representing a two-channel scenario. In the DA channel, some process reduces the hydrogen layer mass to the value of less than 10 to the -7th. The non-DA channel is similar to that in the primordial scenario. These considerations suggest that some mechanism operates in both channels to reduce the thickness of the outermost layer of the white dwarf. It is also noted that accretion from the interstellar medium has little to do with whether a particular white dwarf becomes a DA or a non-DA star.

  5. Recent metallic materials for biomedical applications

    NASA Astrophysics Data System (ADS)

    Niinomi, Mitsuo

    2002-03-01

    Metallic biomaterials are mainly used for replacing failed hard tissue. The main metallic biomaterials are stainless steels, Co-based alloys, and titanium and its alloys. Recently, titanium alloys are getting much attention for biomaterials. The various kinds of new high strength α+ β and low-modulus β-type titanium alloys composed of nontoxic elements, such as Nb, Ta, Zr, etc., are developed for biomedical applications because of the toxicity of alloying elements and lack of mechanical biocompatibility of conventional titanium alloys, such as Ti-6Al-4V. Recent research and development in other metallic alloys, such as stainless steels and Co-based alloys, also will be discussed.

  6. Recent Advances in Natural Product Discovery

    PubMed Central

    Luo, Yunzi; Cobb, Ryan E.; Zhao, Huimin

    2014-01-01

    Natural products have been and continue to be the source and inspiration for a substantial fraction of human therapeutics. Although the pharmaceutical industry has largely turned its back on natural product discovery efforts, such efforts continue to flourish in academia with promising results. Natural products have traditionally been identified from a top-down perspective, but more recently genomics- and bioinformatics-guided bottom-up approaches have provided powerful alternative strategies. Here we review recent advances in natural product discovery from both angles, including diverse sampling and innovative culturing and screening approaches, as well as genomics-driven discovery and genetic manipulation techniques for both native and heterologous expression. PMID:25260043

  7. Recent advances in understanding norovirus pathogenesis.

    PubMed

    Karst, Stephanie M; Tibbetts, Scott A

    2016-11-01

    Noroviruses constitute a family of ubiquitous and highly efficient human pathogens. In spite of decades of dedicated research, human noroviruses remain a major cause of gastroenteritis and severe diarrheal disease around the world. Recent findings have begun to unravel the complex mechanisms that regulate norovirus pathogenesis and persistent infection, including the important interplay between the virus, the host immune system, and commensal bacteria. Herein, we will summarize recent research developments regarding norovirus cell tropism, the use of M cells, and commensal bacteria to facilitate norovirus infection, and virus, host, and bacterial determinants of persistent norovirus infections. J. Med. Virol. 88:1837-1843, 2016. © 2016 Wiley Periodicals, Inc. PMID:27110852

  8. Long Noncoding RNA: Recent Updates in Atherosclerosis

    PubMed Central

    Li, Hao; Zhu, Hongming; Ge, Junbo

    2016-01-01

    Long noncoding RNAs belong to a class of noncoding RNAs longer than 200 nucleotides with the epigenetic regulation potential. As a novel molecular regulator, lncRNAs are often dysregulated in various pathological conditions and display multiple functions in a wide range of biological processes. Given that recent studies have indicated that lncRNAs are involved in atherosclerosis-related smooth muscle cell, endothelial cell, macrophage and lipid metabolism regulation, it is pertinent to understand the potential function of lncRNAs in atherosclerosis development. This review will highlight the recent updates of lncRNAs in atherogenesis and also discuss their potential roles as novel therapeutic targets. PMID:27314829

  9. Recent Advances in Engineering Polyvalent Biological Interactions

    PubMed Central

    2015-01-01

    Polyvalent interactions, where multiple ligands and receptors interact simultaneously, are ubiquitous in nature. Synthetic polyvalent molecules, therefore, have the ability to affect biological processes ranging from protein–ligand binding to cellular signaling. In this review, we discuss recent advances in polyvalent scaffold design and applications. First, we will describe recent developments in the engineering of polyvalent scaffolds based on biomolecules and novel materials. Then, we will illustrate how polyvalent molecules are finding applications as toxin and pathogen inhibitors, targeting molecules, immune response modulators, and cellular effectors. PMID:25426695

  10. Recent Advances in the LEWICE Icing Model

    NASA Technical Reports Server (NTRS)

    Wright, William B.; Addy, Gene; Struk, Peter; Bartkus, Tadas

    2015-01-01

    This paper will describe two recent modifications to the Glenn ICE software. First, a capability for modeling ice crystals and mixed phase icing has been modified based on recent experimental data. Modifications have been made to the ice particle bouncing and erosion model. This capability has been added as part of a larger effort to model ice crystal ingestion in aircraft engines. Comparisons have been made to ice crystal ice accretions performed in the NRC Research Altitude Test Facility (RATFac). Second, modifications were made to the run back model based on data and observations from thermal scaling tests performed in the NRC Altitude Icing Tunnel.