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Atenolol is used alone or in combination with other medications to treat high blood pressure. It also ... pain) and improve survival after a heart attack. Atenolol is in a class of medications called beta ...


[Spectrofluorometric analysis of propranolol and atenolol].  


The optimal conditions for spectrofluorimetric determination of propranolol and atenolol in substance and pharmaceutical preparations were determined. Simultaneous comparison with spectrophotometric method was performed. PMID:16092403

Gajewska, M; Glass, G; Kostelecki, J



Effect of atenolol on birth weight  

Microsoft Academic Search

In conclusion, this survey suggests that atenolol use may be detrimental in early pregnancy and provides confirmatory data with previous small prospective randomized trials.1,10 Our findings suggest that atenolol should be avoided in women who are trying to conceive or who are in the early stages of pregnancy.

Gregory Y. H. Lip; Michèle Beevers; David Churchill; Lara M. Shaffer; D. Gareth Beevers



Effect of topical atenolol on intraocular pressure  

Microsoft Academic Search

Placebo and topical atenolol (Tenormin), a selective beta1-adrenergic blocking substance with no intrinsic sympathomimetic or membrane-stabilising properties, were tested in 16 patients with ocular hypertension in a double-blind cross-over trial. Three different concentrations of atenolol (1, 2, and 4%) were investigated. After a single instillation there was a statistically significant fall in mean intraocular pressure (IOP) with all the concentrations

K. Wettrell; M. Pandolfi



Formulation and stability evaluation of extemporaneously prepared atenolol capsules from crushed atenolol tablets.  


The purpose of this study was to formulate a 25-mg atenolol capsule starting from a commercial 100-mg atenolol tablet, given the fact that this strength is not available in Palestine and also because 50-mg atenolol tablets failed the splitting uniformity test of the European Pharmacopoeia, and to evaluate the chemical stability and dissolution behavior of the obtained capsules so as to ensure a high-quality product. A high-performance liquid chromatographic system was used for the analysis and quantification of atenolol in the samples studied. Samples of atenoIol for analysis were prepared as reported by the United States Pharmacopeia monograph. Disintegration and dissolution tests were performed according to the United States Pharmacopeia. The high-performance liquid chromatography assay indicated that the 25-mg atenolol capsules were stable for four months when stored at ambient temperature conditions. The disintegration time for all atenolol capsules was within the United States Pharmacopeia limits of 15 minutes. Atenolol release profile showed that approximately 90% of atenolol dissolved after 10 minutes. This study is important for patients who need to take one half of a 50-mg tablet, but for whom the splitting process doesn't give equal halves, and also for modifying the dose for patients with renal or hepatic problems. Therefore, it is possible for the community pharmacist to crush atenolol 100-mg tablets and refill them in new capsules with each containing a precise amount of atenolol, calculated according to body surface area and kidney and liver functions without affecting the chemical stability of the active ingredient nor its dissolution profile and also have a cost effective dosage form. PMID:23050394

Zaid, Abdel Naser; Malkieh, Numan; Kharoaf, Maher; Abu Ghoush, Abeer; Al-Ramahi, Rowa'



Comparison of atenolol and propranolol during insulin-induced hypoglycaemia  

Microsoft Academic Search

The effects of atenolol, a new beta1-blocking drug, on pulse rate, sweating, and blood glucose levels during insulin-induced hypoglycaemia were studied in a double-blind crossover trial in eight normal subjects using placebo and propranolol as reference agents. The intensity of induced hypoglycaemia was identical for atenolol, propranolol, and placebo. Propranolol prolonged hypoglycaemia, but atenolol did not. Atenolol may therefore be

S P Deacon; D Barnett



Controlled study of atenolol in treatment of hypertension  

Microsoft Academic Search

The antihypertensive effect of atenolol, a new beta-1-receptor blocking agent, was studied in a double-blind trial in which 45 patients with essential hypertension were randomly assigned to placebo or atenolol treatment. Atenolol caused a statistically significant and clinically relevant reduction of blood pressure. The optimum daily dose for moderately severe hypertension was considered to be 200 mg. Several irrelevant side

L Hansson; H Aberg; B E Karlberg; A Westerlund



Social Phobia: A Comparison of Behavior Therapy and Atenolol.  

ERIC Educational Resources Information Center

Randomly assigned 72 social phobics to behavioral (flooding) or drug treatment with atenolol or placebo. Found that flooding consistently was superior to placebo, whereas atenolol was not. Flooding also was superior to atenolol on behavioral measures and composite indexes. Subjects who improved during treatment maintained gains at six-month…

Turner, Samuel M.; And Others



Atenolol in Secondary Prevention after Stroke  

Microsoft Academic Search

This study investigated the effect of 50 mg atenolol in reducing the risk of death, stroke and myocardial infarction after stroke and transient ischaemic attacks (TIA). The study was designed as a Swedish multicentre, randomised, double-blind, parallel group study with randomisation stratified according to age and prognostic score. Seven hundred and twenty patients aged over 40 years who had no

Sture Eriksson; Bert-Ove Olofsson; Per-Olov Wester



Imugenicidade e segurança da vacina contra influenza A H1N1/2009 em pacientes com dermatomiosite juvenil.  

E-print Network

??Objetivos: Avaliar a imunogenicidade e segurança da vacina anti-influenza A/H1N1 2009 em pacientes com dermatomiosite juvenil (DMJ) comparados com controles saudáveis e a possível associação… (more)

Vanessa Ramos Guissa



Infrared spectroscopy of racemic and enantiomeric forms of atenolol  

NASA Astrophysics Data System (ADS)

The molecular structure of conformational isomorphs given by X-ray diffraction for racemic and enantiomeric atenolol were optimized at the HF/6-31G* level of theory and the infrared spectra of the structure were calculated. These spectra are used to characterize the differences between the various atenolol conformers. The spectra of the ( R, S)- and S-atenolol solid forms were recorded and the bands corresponding to the functional groups identified with the aid of the calculated spectra, fitting analysis, temperature effect and H/D isotopic exchange. Particular attention was paid to the stretch vibration modes of the functional groups present in the atenolol.

de Castro, R. A. Esteves; Canotilho, João; Barbosa, Rui M.; Redinha, J. Simões



Atenolol in essential hypertension during pregnancy  

Microsoft Academic Search

OBJECTIVE--To determine the effect of atenolol on the outcome of pregnancy in women with essential hypertension. DESIGN--Prospective, randomised, double blind, placebo controlled study. SETTING--Hospital clinic. PATIENTS--33 Women with mild essential hypertension (systolic blood pressure 140-170 mm Hg or diastolic pressure 90-110 mm Hg on two occasions at least 24 hours apart) consecutively referred to two obstetric medical clinics. Four patients

L Butters; S Kennedy; P C Rubin



Pharmacokinetics of atenolol in patients with renal impairment  

Microsoft Academic Search

The pharmacokinetics of atenolol, a new cardioselective ß-adrenoceptor blocking agent, were determined following both acute and chronic dosing in 33 hypertensive patients with widely differing levels of renal impairment. In patients with normal renal function the atenolol half-life was calculated to be about six hours following single 100 mg oral doses. This value increased markedly in patients with renal insufficiency

J. Sassard; N. Pozet; J. McAinsh; J. Legheand; P. Zech



Atenolol and fetal growth in pregnancies complicated by hypertension  

Microsoft Academic Search

Atenolol use may be associated with growth retardation when given in pregnancy, although the relationship to trimester of initiation, duration of treatment, and its use as monotherapy is still uncertain. To compare the obstetric and fetal outcome between women receiving atenolol (as monotherapy) and other antihypertensive drug monotherapies, and also to investigate the effect of duration of treatment on fetal

Charalampos Lydakis; Gregory Y. H. Lip; Michèle Beevers; D. Gareth Beevers



Studies on the pharmacokinetics and pharmacodynamics of atenolol in man  

Microsoft Academic Search

The non-stimulant cardioselective beta adrenocepter antagonist atenolol has been studied in volunteers in order to define its pharmacokinetic characteristics. Atenolol (100 and 200 mg orally) is rapidly absorbed, reductions in heart rate and systolic pressure being observed in 30 min. The effect persists for up to 8 h. Over 85% of an intravenous dose is excreted in urine within 24

J. D. Fitzgerald; R. Roberts; K. G. Smedstad; J. McAinsh



Supervised atenolol therapy in the management of hemodialysis hypertension  

Microsoft Academic Search

Supervised atenolol therapy in the management of hemodialysis hypertension.BackgroundUncontrolled hypertension continues to be a common problem, particularly in noncompliant hemodialysis patients. Atenolol, a water soluble ?-blocker has a prolonged half-life in renal failure and may serve as a useful antihypertensive agent in these patients.MethodsHypertension was diagnosed by ambulatory blood pressure monitoring for 44 hours during an interdialytic interval in eight

Rajiv Agarwal



Spectrophotometry Determination of Atenolol via Hydroxamic acid Formation  

Microsoft Academic Search

A simple spectrophotometric method for the determination of atenolol by hydroxamic acid formation in dosage forms is described. Atenolol (2-p-hydroxy-3-isopropylaminopropoxy phenyl-acetamide) reacts with hydroxylamine hydrochloride in alkaline medium to give 2-p-hydroxy-3-iso-propyl amino-propoxyphenyl aceto hydroxamic acid, which forms a reddish violet coloured complex with Iron(III) in acidic medium having maximum absorbance at 510 nm, and molar absorbtivity 5.3 × 10

Y. K. Agrawal; K. Raman; S. Rajput; S. K. Menon



Comparison of the effects of doxazosin and atenolol on target organ damage in adults with type 2 diabetes mellitus and hypertension in the CARDHIAC study: A 9-month, prospective, randomized, open-label, blinded-evaluation trial  

Microsoft Academic Search

Objective: The CARDHIAC® (CARduran en pacientes Diabéticos con HIpertensi'on Arterial no Controlada) trial examined the effects of doxazosin gastrointestinal therapeutic system (GITS) and atenolol on 3 separate measures of target-organ damage-left ventricular mass index (LVMI), carotid intima media thickness (IMT), and urinary albumin excretion (UAE) in patients with type 2 diabetes mellitus and hypertension.Method: This trial had a prospextive, open-label,

Vivencio Barrios; Carlos Escobar; Juan Pablo Tomás; Alberto Calderon; Rocío Echarri



Food-induced reduction in bioavailability of atenolol  

Microsoft Academic Search

The influence of food intake on the bioavailability of the beta-adrenoceptor blocker atenolol was assessed by measurement of its single-dose kinetics in ten healthy volunteers, who took 100 mg both in the fasting state and together with a standardized breakfast. Food intake significantly shortened the time to reach peak concentration (2.7 h vs 1.5 h), but caused a significant reduction

A. Melander; P. Stenberg; H. Liedholm; B. Scherstén; E. Wåhlin-Boll



Defining the chronic impacts of atenolol on embryo-larval development and reproduction in the fathead minnow ( Pimephales promelas)  

Microsoft Academic Search

Atenolol is a ?-adrenergic receptor antagonist (‘?-blocker’) widely used for the treatment of angina, glaucoma, high blood pressure and other related conditions. Since atenolol is not appreciably metabolized in humans, the parent compound is the predominant excretory product, and has been detected in sewage effluent discharges and surface waters. Consequently, atenolol has been chosen as a reference pharmaceutical for a

Matthew J. Winter; Adam D. Lillicrap; John E. Caunter; Christian Schaffner; Alfredo C. Alder; Maria Ramil; Thomas A. Ternes; Emma Giltrow; John P. Sumpter; Thomas H. Hutchinson



Pharmacokinetics and pharmacodynamics of controlled-release metoprolol: A comparison with atenolol  

Microsoft Academic Search

Summary Pharmacokinetic and pharmacodynamic properties of a new controlled-release (CR) formulation of metoprolol1 have been compared with those of atenolol2. Metoprolol CR (100 mg and 200 mg), atenolol (50 mg and 100 mg) and placebo were each given once daily for four days in a double-blind, cross-over study to ten healthy men.

I. Blomqvist; G. Westergren; A. Sandberg; U. E. Jonsson; P. Lundborg



Reduction of ventricular arrhythmias by early intravenous atenolol in suspected acute myocardial infarction  

Microsoft Academic Search

The effect of intravenous atenolol on ventricular arrhythmias in acute myocardial infarction was assessed in 182 patients admitted within 12 hours of the onset of chest pain. Ninety-five patients were randomised to receive 5 mg intravenous atenolol followed immediately by 50 mg by mouth and 50 mg 12 hours later, then 100 mg daily for 10 days; 87 patients served

P R Rossi; S Yusuf; D Ramsdale; L Furze; P Sleight



Once-daily dosing with Atenolol in patients with mild or moderate hypertension  

Microsoft Academic Search

Because of the difficulties patients have in adhering to their drug regimens a trial was performed in which patients with essential hypertension were given, in random order and for four weeks each, three different doses of atenolol to be taken once daily. Atenolol effectively decreased lying and standing blood pressures, and there was no difference between the effects of the

A P Douglas-Jones; J M Cruickshank



Treatment of angina pectoris with nifedipine and atenolol: efficacy and effect on cardiac function  

Microsoft Academic Search

The antianginal effects of nifedipine 20 mg three times a day and atenolol 100 mg once a day singly and in combination were investigated in 16 patients with angina pectoris. The amount of work that could be done before angina and ST depression appeared was significantly increased by atenolol and the combination but not by nifedipine. At peak exercise the

I N Findlay; K MacLeod; M Ford; G Gillen; A T Elliott; H J Dargie



Importance of ancillary properties of beta blockers in angina: a study of celiprolol and atenolol  

Microsoft Academic Search

Celiprolol (400 mg) and atenolol (100 mg) were given once a day to 16 patients with stable angina pectoris in a double blind placebo controlled crossover study. Celiprolol produced less suppression of heart rate both at rest and during exercise than atenolol. Both drugs were equally effective in reducing the frequency of angina and in delaying the onset of ischaemia

J M McLenachan; J T Wilson; H J Dargie



Kinetic spectrophotometric determination of atenolol in dosage forms.  


A simple kinetic procedure is described for the determination of atenolol in its dosage forms. The procedure is based on coupling the drug with 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole in pH 8 borate buffer at the boiling temperature for a fixed time of 30 min, and then measuring the absorbance of the reaction product at 460 nm. The absorbance-concentration plot is rectilinear over the range 5-50 microg/mL with a minimum detection limit of 1.3 microg (4.9 x 10(-6) M). The determination of atenolol by the fixed-concentration and rate-constant methods is also feasible with the calibration equations obtained, but the fixed-time method proved to be more applicable. The procedure was applied successfully to commercial tablets, and statistical analysis showed that the results compared favorably with those obtained by the official methods. The interference likely to be introduced from some coformulated drugs and the effect of sensitizers and surfactants on the performance of the proposed method were also studied. A proposed reaction pathway is presented. PMID:12180673

Al-Ghannam, Sheikha M; Belal, Fathalla



A method for content uniformity determination of atenolol and losartan potassium in combined tablet dosage form.  


A simple, accurate, rapid, specific and reproducible UV spectrophotometric method was developed for estimation of content uniformity of atenolol and losartan potassium in its combined tablet dosage form. The method involves formation and solving the simultaneous equation using 226.4 and 254 nm as two wavelengths for atenolol and losartan, respectively. Developed method was employed to determine the atenolol and losartan content in ten individual tablet units of five market formulations. Methanol was used as solvent. The method was validated. From the results, it was concluded that all brands are within the content uniformity limit, 85-115%. PMID:21969756

Shah, S A; Vyas, R B; Vyas, B A; Maniyar, N R; Chauhan, R S; Shah, D R




EPA Science Inventory

Atenolol is a cardioselective B-adrenoreceptor blocking agent, used for treatment of hypertension, including hypertension in pregnancy. Beta-adrenoreceptor antagonists have been impacted in the production of intrauterine growth retardation and considerable range of neonatal probl...


beta blockade and intermittent claudication: placebo controlled trial of atenolol and nifedipine and their combination  

Microsoft Academic Search

OBJECTIVE--To determine the effects of the beta 1 selective adrenoceptor blocker atenolol, the dihydropyridine calcium antagonist nifedipine, and the combination of atenolol plus nifedipine on objective and subjective measures of walking performance and foot temperature in patients with intermittent claudication. DESIGN--Randomised controlled double blind four way crossover trial. SETTING--Royal Hallamshire Hospital, Sheffield. SUBJECTS--49 patients (40 men) aged 39-70 with chronic

S A Solomon; L E Ramsay; W W Yeo; L Parnell; W Morris-Jones



Randomised controlled trial of atenolol and pindolol in human pregnancy: effects on fetal haemodynamics  

Microsoft Academic Search

OBJECTIVE--To compare the effects of uteroplacental circulation of two beta adrenoceptor blockers, atenolol (cardioselective) and pindolol (non-selective with intrinsic sympathomimetic activity). DESIGN--Controlled double blind double dummy study. SETTING--Departments of obstetrics and gynaecology in two Swedish university hospitals. SUBJECTS--29 women with pregnancy induced hypertension in the third trimester, 13 randomised to atenolol and 16 to pindolol. MAIN OUTCOME MEASURES--Pulsatility index in

S. Montan; I. Ingemarsson; K. Marsál; N.-O. Sjoberg



Effects of Atenolol Versus Enalapril on Cardiovascular Fitness and Serum Lipids in Physically Active Hypertensive Men  

Microsoft Academic Search

An ideal drug regimen for physically active hypertensive patients should not offset exercise-induced improvements in cardiovascular health or fitness. In this randomized, double-blind, placebo-controlled, crossover study of 39 physically active men with uncomplicated essential hypertension, we compared the effects of atenolol and enalapril on cardiovascular fitness and serum lipids. Drugs (atenolol, 50 or 100 mg once daily; enalapril, 10 or



Different hemodynamic effects of celipropol and atenolol in patients with mild to moderate hypertension.  


The hemodynamic effects of celiprolol (CAS 56980-93-9), a betablocker with beta 1 antagonist and beta 2 agonist properties, were compared with those of atenolol (CAS 29122-68-7) in 12 patients with mild to moderately severe hypertension (diastolic BP 95-110 mmHg). Celiprolol and atenolol lead to a similar and significant reduction of systolic and diastolic blood pressure (p < 0.005). However, with celiprolol heart rate at rest was significantly less depressed then with atenolol (p = 0.004) and showed a distinctly less pronounced depression of heart rate with exercise (p = 0.004). Cardiac output at rest was reduced by 19% under atenolol, but was increased by 9% under celiprolol treatment; in this respect, the two medications differed significantly (p = 0.03). The adaptation of heart rate and cardiac output to exercise was better with celipropol as compared to atenolol treatment. The difference between arm arterial pressure and ankle occlusion pressure at rest was not significantly influenced by atenolol, whereas celiprolol treatment increased this difference by a mean of up to 16 mmHg (p = 0.009). This different effect on peripheral arterial circulation was even more pronounced after exercise. Both celiprolol and atenolol increased blood cell flow velocity in the nailfold capillaries, but this increases was statistically only significant with celiprolol (p = 0.047). These results demonstrate that the hemodynamic effects of celiprolol were significantly different from those of atenolol; celiprolol produces less bradycardia, increases cardiac output at rest and decreases peripheral arterial resistance.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:8573224

Saner, H; Seiler, A; Mahler, F



Beneficial Effects of Nebivolol in Comparison with Atenolol on Safety and Tolerability in Essential Hypertension  

PubMed Central

Introduction: Hypertension, “The silent killer” is a multifactorial disorder which is asymptomatic and if left untreated leads to lethal complications. Nebivolol is a third generation beta blocker with additional vasodilating property due to nitric oxide release. Aim: The current study aims to assess efficacy and safety of Nebivolol and compare with Atenolol. Methods: This was prospective, double blind, comparative controlled clinical study. Total 90 patients were enrolled into study as per selection criteria. Patients were randomized to receive Atenolol and Nebivolol with 45 patients in each group for 12 weeks. Results and Conclusion: The mean reduction diastolic blood pressure in Nebivolol and Atenolol group was 10.77±2.60 and 10.05±2.83 respectively. The number of patients with adverse effect events was higher in the Atenolol than in the Nebivolol group (36.84% of Atenolol Vs 12.82% of Nebivolol). Thus it can be concluded that, for the same antihypertensive effect, Nebivolol was better tolerated than Atenolol. PMID:25120998

Inamdar, S.C.; V.B., Karande; S.R., Burute; M.B., Murthy; A., Ghatak



Early intravenous atenolol treatment in suspected acute myocardial infarction. Preliminary report of a randomised trial.  


214 patients were studied in a randomised trial to determine whether administraiton of intravenous atenolol within 12 hours of chest pain reduced eventual infarct size, as estimated by cumulative enzyme release and by ECG changes. 135 patients already had ECG evidence of infarction at entry; 72 received atenolol which significantly decreased subsequent enzyme release (atenolol and control means = 121 IU, SE +/- 10 and 177 IU, SE +/- 17; 2p < 0.005) and enhanced R-wave preservation (atenolol and control means = 46% +/- 3 and 36% +/- 3; 2p < 0.02). 79 patients had no evidence of infarction at entry; 44 did not receive atenolol and 27 of these subsequently developed infarction, whereas only 11 of 35 treated patients infarcted during their hospital stay (2p < 0.01). In hospital, fewer atenolol patients died (4 vs 9), had non-fatal cardiac arrests (2 vs 6), or required therapy for heart-failure (36 vs 47). Unlike many previous trials which had negative results, in this trial we gave the drug intravenously and promptly (median of 4 hours from onset of pain to injecton), thereby achieving early beta-blockade. PMID:6105436

Yusuf, S; Ramsdale, D; Peto, R; Furse, L; Bennett, D; Bray, C; Sleight, P



The sub-lethal effects and tissue concentration of the human pharmaceutical atenolol in rainbow trout (Oncorhynchus mykiss).  


Atenolol is a highly prescribed anti-hypertensive pharmaceutical and a member of the group of ?-blockers. It has been detected at concentrations ranging from ng L(-1) to low ?g L(-1) in waste and surface waters. The present study aimed to assess the sub-lethal effects of atenolol on rainbow trout (Oncorhynchus mykiss) and to determine its tissue-specific bioconcentration. Juvenile rainbow trout were exposed for 21 and 42 days to three concentration levels of atenolol (1 ?g L(-1) - environmentally relevant concentration, 10 ?g L(-1), and 1000 ?g L(-1)). The fish exposed to 1 ?g L(-1) atenolol exhibited a higher lactate content in the blood plasma and a reduced haemoglobin content compared with the control. The results show that exposure to atenolol at concentrations greater than or equal to 10 ?g L(-1) significantly reduces both the haematocrit value and the glucose concentration in the blood plasma. The activities of the studied antioxidant enzymes (catalase and superoxide dismutase) were not significantly affected by atenolol exposure, and only the highest tested concentration of atenolol significantly reduced the activity of glutathione reductase. The activities of selected CYP450 enzymes were not affected by atenolol exposure. The histological changes indicate that atenolol has an effect on the vascular system, as evidenced by the observed liver congestion and changes in the pericardium and myocardium. Atenolol was found to have a very low bioconcentration factor (the highest value found was 0.27). The bioconcentration levels followed the order liver>kidney>muscle. The concentration of atenolol in the blood plasma was below the limit of quantification (2.0 ng g(-1)). The bioconcentration factors and the activities of selected CYP450 enzymes suggest that atenolol is not metabolised in the liver and may be excreted unchanged. PMID:25129157

Steinbach, Christoph; Burkina, Viktoriia; Fedorova, Ganna; Grabicova, Katerina; Stara, Alzbeta; Velisek, Josef; Zlabek, Vladimir; Schmidt-Posthaus, Heike; Grabic, Roman; Kocour Kroupova, Hana



Comparison of effects on systolic and diastolic left ventricular function of nebivolol versus atenolol in patients with uncomplicated essential hypertension  

Microsoft Academic Search

This was a double-blind, randomized, prospective study comparing the effects of nebivolol and atenolol on systolic diastolic left ventricular function in patients with essential hypertension. A significant difference was seen in stroke volume between these 2 drugs. The blood pressure lowering effect of atenolol was strongly related to cardiac output and heart rate reduction. The blood pressure lowering effect of

Otto Kamp; Gertjan T. Sieswerda; Cees A. Visser




PubMed Central

Este estudo avalia quanto o corpo médico do Hospital Dr. Darío Contreras de República Dominicana conhece, respeita, informa e aplica a Lei Geral de Saúde em relação aos direitos do paciente Testemunha de Jeová de negar-se a ser transfundido (respeito a sua autonomia); também se os Testemunhas de Jeová conhecem a Lei Geral de Saúde e até que ponto têm se beneficiado diante dessa proposição. O estudo revelou que nem médicos, nem Testemunhas de Jeová conhecem de fato essa lei. PMID:20689657




Arterial Pressure Lowering Effect of Chronic Atenolol Therapy in Hypertension and Vasoconstrictor Sympathetic Drive  

PubMed Central

Although the ?1-adrenergic blocking agent atenolol is an established antihypertensive therapy, its effect on peripheral sympathetic vasoconstrictor drive has remained controversial. In patients with hypertension, atenolol therapy has been reported to either increase or have no effect on peripheral vascular resistance, despite other reports showing no change or a decrease in peripheral sympathetic drive. This study was designed, in patients with untreated essential hypertension (EHT), to quantify changes in simultaneously measured peroneal muscle sympathetic nerve activity (MSNA) and calf vascular resistance (CVR) accompanying atenolol therapy. MSNA was quantified as the mean frequency of single units (s-MSNA) and as multiunit bursts (MSNA bursts) using the technique of microneurography, and CVR was measured using a standard plethysmographic technique. Firstly, by comparing two age- and body weight-matched groups, each of 14 patients with hypertension, we found that the group on atenolol therapy (treated-HT) had similar MSNA values counted over the same number of cardiac beats and similar CVR levels (at least P>0.40) to the group without therapy (untreated-HT). Secondly, we examined 10 EHT patients before and after 8±0.4 weeks of oral atenolol therapy (HT-A) in comparison to seven control patients with hypertension and no treatment (HT-C) who were examined over a similar period of time. We found that the measures of MSNA and CVR did not significantly change in both groups. We conclude that the arterial pressure lowering effect of atenolol was not related to significant changes in central vasoconstrictor sympathetic drive to the periphery. PMID:15326085

Burns, Joanna; Mary, David A.S.G.; Mackintosh, Alan F.; Ball, Stephen G.; Greenwood, John P.



Type 2 diabetes-induced cardiovascular complications: comparative evaluation of spironolactone, atenolol, metoprolol, ramipril and perindopril.  


The present study was carried out to study the effect of spironolactone, atenolol, metoprolol, ramipril and perindopril on cardiovascular complications in neonatal model of diabetes in rats, induced by administering 90?mg/kg streptozotocin (STZ), i.p. in 2-day-old rats. Our data suggest that spironolactone, metoprolol and perindopril prevent not only the STZ-induced metabolic abnormalities but also cardiovascular complications as evident from the reduction in cholesterol, triglyceride and decrease in cardiac hypertrophy which are the initial symptoms of congestive heart failure. Metoprolol and perindopril appears to be beneficial agents as compared to atenolol and ramipril. PMID:24047125

Patel, Bhoomika M; Bhadada, Shraddha V



Acebutolol, atenolol, and propranolol and metabolic responses to acute hypoglycaemia in diabetics  

Microsoft Academic Search

In a double-blind crossover study the symptomatic and metabolic effects of propranolol, acebutolol, and atenolol were studied during insulin-induced hypoglycaemia in diabetics treated with diet or hypoglycaemic tablets. All the drugs prevented tachycardia, but did not affect the other symptoms of hypoglycaemia. Propranolol delayed the recovery of the blood glucose concentration and impaired the secondary rise in the concentrations of

S P Deacon; A Karunanayake; D Barnett



Atenolol and amlodipine combination overdose managed with continuous venovenous hemodiafiltration: A case report.  


We present a patient of who ingested large dose of of atenolol and amlodipine and was treated successfully with continuous venovenous hemodiafiltration. Early recognition of indications for renal support and early initiation of the same is the key to successful management. PMID:25249727

Sandeep, P; Ram, R; Sowgandhi, N; Reddy, S A; Katyarmal, D T; Kumar, B S; Kumar, V S



Immediate haemodynamic effects of propranolol, practolol, pindolol, atenolol and ICI 89,406 in healthy volunteers  

Microsoft Academic Search

Changes in cardiac output, heart rate and arterial blood pressure were determined in 31 healthy volunteers after i. v. administration of equipotent doses of five different adrenergic betareceptor blocking drugs. Propranolol was given to seven subjects, atenolol to five, practolol to seven, pindolol to five, and (a new drug) ICI 89,406 to seven. Each drug was given in six logarithmically

T. Lysbo Svendsen; O. Hartling; J. Trap-Jensen



Atenolol gastrointestinal therapeutic system: optimization of formulation variables using response surface methodology  

Microsoft Academic Search

Osmotically controlled drug delivery systems are of interest for the maintenance of constant drug levels in essential hypertension. The objective of this study was to prepare and evaluate an optimized, osmotically controlled formulation of a model drug, atenolol. Preparation involved the fabrication of biconvex, bilayered tablets containing drug, an osmotic agent and other additives. Earlier studies on the screening of

Srikonda V. Sastry; Indra K. Reddy; Mansoor A. Khan



Design, Synthesis, and In Vitro Kinetics Study of Atenolol Prodrugs for the Use in Aqueous Formulations  

PubMed Central

Based on DFT, MP2, and the density functional from Truhlar group (hybrid GGA: MPW1k) calculations for an acid-catalyzed hydrolysis of nine Kirby's N-alkylmaleamic acids and two atenolol prodrugs were designed. The calculations demonstrated that the amide bond cleavage is due to intramolecular nucleophilic catalysis by the adjacent carboxylic acid group and the rate-limiting step is determined based on the nature of the amine leaving group. In addition, a linear correlation of the calculated and experimental rate values has drawn credible basis for designing atenolol prodrugs that are bitterless, are stable in neutral aqueous solutions, and have the potential to release the parent drug in a sustained release manner. For example, based on the calculated B3LYP/6-31 G (d,p) rates, the predicted t1/2 (a time needed for 50% of the prodrug to be converted into drug) values for atenolol prodrugs ProD 1-ProD 2 at pH 2 were 65.3 hours (6.3 hours as calculated by GGA: MPW1K) and 11.8 minutes, respectively. In vitro kinetic study of atenolol prodrug ProD 1 demonstrated that the t1/2 was largely affected by the pH of the medium. The determined t1/2 values in 1N HCl, buffer pH 2, and buffer pH 5 were 2.53, 3.82, and 133 hours, respectively. PMID:24526887

Qtait, Alaa; Dajani, Khulod Khayyat; Abu Lafi, Saleh




EPA Science Inventory

Atenolol is a beta-adrenoreceptor blocker used for treatment of hypertension in pregnancy. This study evaluates the reporting frequency of adverse pre- and postnatal outcomes in a series of 70 cases of maternal exposure during gestation, derived from 140 reports to FDA with Ateno...


Abrupt withdrawal of atenolol in patients with severe angina. Comparison with the effects of treatment.  

PubMed Central

The effects of abrupt withdrawal of atenolol, a long acting cardioselective beta blocker, were studied in 20 patients with severe stable angina pectoris admitted to hospital for coronary arteriography. During the 144 hour postwithdrawal period no serious coronary events occurred. Mean and maximal daily heart rates rose steadily for at least 120 hours. No important arrhythmias were noted on ambulatory electrocardiographic monitoring. Treadmill exercise testing at 120 hours showed little reduction in the times to angina, ST depression, and maximal exercise when compared with those recorded at 24 hours. This deterioration was small when contrasted with the improvements in these indices produced by atenolol treatment in a similar group of patients not admitted to hospital. No change in catecholamine concentrations or acceleration of the heart rate response to exercise occurred after atenolol withdrawal, suggesting that rebound adrenergic stimulation or hypersensitivity was absent or insignificant. Catastrophic coronary events after beta blockade withdrawal (the beta blockade withdrawal syndrome) have occurred almost exclusively in patients taking propranolol, many of whom had unstable angina at the time of withdrawal. This study showed that in patients with stable angina, even when severe, the abrupt withdrawal of atenolol can be expected to result in only minor clinical consequences. The risk to any patient of so called rebound events after withdrawal of beta blockade seems to be related to both the clinical setting and the agent being used. PMID:3970785

Walker, P R; Marshall, A J; Farr, S; Bauminger, B; Walters, G; Barritt, D W



Simultaneous Assay of Atenolol and Nifedipine by UV Derivative Spectrophotometry and Gaschromatography  

Microsoft Academic Search

A rapid, simple, and accurate UV derivative method for the simultaneous determination of atenolol and nifedipine in dosage forms was developed. A new gaschromatographic procedure was also defined to convalide the spectrophotometric procedure as an alternative method. Statistical analysis of the results on data from laboratory solutions confirms a good accuracy and precision of both the methods.

M. Veronico; G. Ragno; C. Vetuschi



Study on the possible interaction between tenoxicam and atenolol in hypertensive patients.  


Sixteen hypertensive male out-patients (33-54 y), whose blood pressure (BP) had been normalized (diastolic BP < 90 mmHg) by treatment with a daily dose of 50 mg atenolol (CAS 29122-68-7), participated in this double-blind, placebo-controlled, parallel group study, which investigated the possible influence of the non-steroidal anti-inflammatory drug tenoxicam (CAS 59804-37-4) on the control of BP by atenolol. After a run-in of 10 days, to assess the stability of BP control by atenolol, and to determine baseline parameters, 8 patients in group A received 20 mg tenoxicam (2 x 20 mg on days 1 and 2), and 8 patients in group B received placebo, daily over 15 days (days 0-14), concomitantly with their atenolol regimen. BP was measured under standardized conditions on several days. Heart rate (EHR) after 5 min of exercise by bicycle ergometry (constant 75W), and parameters of renal function were assessed before (baseline) and during concomitant dosing of atenolol and tenoxicam. On day 14 the mean changes (delta A, delta B) from baseline of pre-dose BP (mmHg) and EHR (beats/min) in groups A and B, and the one-sided 95% confidence regions (R) for delta A, respectively, were (delta A, delta B, R): 4.4, 1.6, < 9.5 for sitting systolic BP, 2.8, -0.3, < 4.5 for sitting diastolic BP, -0.3, -0.6, < 5.5 for standing systolic BP, -0.6, -1.9, < 3.0 for standing diastolic BP, 0.4, -7.5, < 0.4 for EHR at pre-dose, 3.1, 0.6, < 7.8 for EHR at 3.5 h post-dose.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:7779149

Hartmann, D; Stief, G; Lingenfelder, M; Güzelhan, C; Horsch, A K



Semina: Cincias Biolgicas e da Sade, Londrina, v. 34, n. 1, p. 55-62, jan./jul. 2013 A comunicao da equipe de enfermagem com o paciente em cuidados  

E-print Network

A comunicação da equipe de enfermagem com o paciente em cuidados paliativos The communication of the nursing for effective communication among the nursing, terminally ill and his family. In that sense, it was observed aspects that enable developing empathic communication skills, perceived as a task that requires nursing

Paris-Sud XI, Université de


Spectrophotometric method for simultaneous estimation of atenolol in combination with losartan potassium and hydrochlorothiazide in bulk and tablet formulation  

PubMed Central

Aim: To develop a simple, accurate, rapid and precise UV spectrophotometric method for the estimation of atenolol in combination with losartan potassium and hydrochlorothiazide. Materials and Methods: The method employs formation and solving simultaneous equation using 251.60 nm and 224.20 nm for losartan potassium and atenolol, 224.20 and 271.60 for atenolol and hydrochlorothiazide as two analytical wavelengths, using methanol water as a solvent. Results and Conclusion: The linearity was observed in the concentration range of 5-30 µg/ml (r=0.9991) for losratan pottassium, 2 - 12 µg/ml (r = 0.9995) for atenolol and 2 - 14 µg/ml (r = 0.9993) for hydrochlorothiazide. The results of the method were validated statistically and by recovery studies. PMID:21180476

Bari, Sanjay; Sathe, Shital; Jain, Pritam; Surana, Sanjay



Effect of antihypertensive treatment with valsartan or atenolol on sexual activity and plasma testosterone in hypertensive men  

Microsoft Academic Search

Objective. To compare the effects of valsartan and atenolol on sexual activity and plasma testosterone in newly diagnosed, previously untreated, essential hypertensive male subjects. Methods. One hundred and ten hypertensive men, aged 40-49 years, homogeneous for marital status and without any previous sexual dysfunction were randomly treated with valsartan 80 mg daily (o.d.) or atenolol 50 mg o.d. for 16

Roberto Fogari; Paola Preti; Giuseppe Derosa; Gianluigi Marasi; Annalisa Zoppi; Andrea Rinaldi; Amedeo Mugellini



Effect of atenolol and reserpine on selected events in the systolic hypertension in the elderly program (SHEP)  

Microsoft Academic Search

The effect of atenolol and reserpine on incidence of strokes, coronary heart disease (CHD), cardiovascular disease (CVD), and mortality was assessed in 4736 persons aged 60 years and older with isolated systolic hypertension. Participants were randomized to either chlorthalidone (2371), with step-up to atenolol, or reserpine if needed, or placebo (2365). The average baseline SBP\\/DBP was 170\\/77 mm Hg. In

John B. Kostis; Kenneth G. Berge; Barry R. Davis; C. Morton Hawkins; Jeffrey Probstfield



A novel solid-phase extraction-spectrofluorimetric method for the direct determination of atenolol in human urine.  


A novel, simple, sensitive and selective solid-phase extraction (SPE)-spectrofluorimetric method has been developed for the determination of atenolol (ATE) in human urine. Because an extraction procedure is required to isolate ATE or eliminate the interfering molecules present in complex human urine for the direct spectrofluorimetric determination, a pH-sensitive poly(acrylic acid-ethylene glycol dimethacrylate) [poly(AA-EGDMA)] hydrogel was developed and used as a SPE adsorbent. Some factors affecting the ATE extraction efficiency, such as washing solvent type and volume, and the volume of elution solvent were optimized. Eluates from SPE cartridges were analyzed using a spectrofluorimeter (?(ex) ?=?277 nm and ?(em) ?=?300 nm). The calibration graph was linear over the concentration range 0.15-4.0 µg/mL. Limit of detection (LOD) and limit of quantification (LOQ) values were found to be 0.03 and 0.10 µg/mL, respectively. Relatively high intraday [2.06%, mean relative standard deviation (RSD)] and interday (2.6%, mean RSD) precisions were achieved. High mean recovery (95.4%) and low RSD values (3.8%) were obtained for spiked ATE in human urine. The spectrofluorimetric method presented here can be easily applied to assay trace amounts of ATE in pharmaceuticals and biological samples. PMID:23733327

Basan, Hasan; Yar?mkaya, Sezen



In-vitro Relationship between Protein-binding and Free Drug Concentrations of a Water-soluble Selective Beta-adrenoreceptor Antagonist (Atenolol) and Its Interaction with Arsenic  

PubMed Central

The degree of binding of a drug to plasma proteins has a marked effect on its distribution, elimination, and pharmacological effect since only the unbound fraction is available for distribution into extra-vascular space. The protein-binding of atenolol was measured by equilibrium dialysis in the bovine serum albumin (BSA). Free atenolol concentration was increased due to addition of arsenic which reduced the binding of the compounds to BSA. During concurrent administration, arsenic displaced atenolol from its high-affinity binding Site I, and free concentration of atenolol increased from 4.286±0.629% and 5.953±0.605% to 82.153±1.924% and 85.486±1.158% in absence and presence of Site I probe respectively. Thus, it can be suggested that arsenic displaced atenolol from its binding site resulting in an increase of the free atenolol concentration in plasma. PMID:19248645

Awal, M.A.; Subhan, N.; Mostofa, M.



Atenolol use and clinical outcomes after thrombolysis for acute myocardial infarction: the GUSTO-I experience  

Microsoft Academic Search

Objectives. We assessed the use and effects of acute intravenous and later oral atenolol treatment in a prospectively planned post hoc analysis of the GUSTO-I dataset.Background. Early intravenous beta blockade is generally recommended after myocardial infarction, especially for patients with tachycardia and\\/or hypertension and those without heart failure.Methods. Besides one of four thrombolytic strategies, patients without hypotension, bradycardia or signs

Matthias Pfisterer; Jafna L Cox; Christopher B Granger; Sorin J Brener; C. David Naylor; Robert M Califf; Frans van de Werf; Amanda L Stebbins; Kerry L Lee; Eric J Topol; Paul W Armstrong



Efficacy and tolerability of losartan potassium and atenolol in patients with mild to moderate essential hypertension  

Microsoft Academic Search

The objective of this study was to compare the antihypertensive efficacy and tolerability of losartan potassium (losartan) and atenolol in patients with mild-to-moderate essential hypertension. This was a multinational, prospective, randomized, 12-week double-blind parallel study with a follow-up of 4 to 10 days posttreatment to assess any adverse effects of abrupt therapy withdrawal.Two hundred two patients were randomized (2: 1)

Bjorn Dahlöf; Susan E. Keller; Lukas Makris; Allan I. Goldberg; Charles S. Sweet; Nicholas Y. Lim



Simultaneous determination of atenolol and amlodipine in tablets by high-performance thin-layer chromatography  

Microsoft Academic Search

A new simple, precise, rapid and selective high-performance thin-layer chromatographic (HPTLC) method has been developed for the simultaneous determination of atenolol (ATL) and amlodipine (AMLO) in tablets, using methylene chloride:methanol:ammonia solution (25% NH3) (8.8:1.3:0.1; v\\/v) as the mobile phase and Merck HPTLC plates (0.2 mm thickness) precoated with 60F254 silica gel on aluminium sheet as the stationary phase. Detection was

A. P. Argekar; S. G. Powar



Randomised trial comparing propranolol with atenolol in immediate treatment of suspected myocardial infarction  

Microsoft Academic Search

The value of beta-blockade for suspected acute myocardial infarction was assessed by determining the six-week and one-year mortality rates in patients started on propranolol, atenolol, or placebo immediately on entry to a coronary care unit. A total of 388 patients entered this double-blind, randomised study, and when analysed on the basis of the initial, intention-to-treat categories there was no significant

R G Wilcox; J M Roland; D C Banks; J R Hampton; J R Mitchell



Fibrinolytic\\/hemostatic variables in arterial hypertension: response to treatment with irbesartan or atenolol  

Microsoft Academic Search

Essential hypertension is often accompanied by abnormalities of the coagulation\\/fibrinolytic system, predisposing to a procoagulant state. The aim of the present study was to compare the effects of atenolol (?1-blocker agent) and irbesartan (angiotensin II type 1 receptor antagonist) on plasma levels of hemostatic\\/fibrinolytic and endothelial function markers in a cohort of previously untreated hypertensives. Fifty-four patients were randomly assigned

Thomas K. Makris; George A. Stavroulakis; Panagiota G. Krespi; Anthony N. Hatzizacharias; Filippos K. Triposkiadis; Caterina G. Tsoukala; Vasilios V. Votteas; Michael K. Kyriakidis



Metabolic consequences of atenolol and propranolol in treatment of essential hypertension  

Microsoft Academic Search

A six-month study of triglyceride, cholesterol, free fatty acid (FFA), glucose, insulin, growth hormone, and glucagon concentrations was carried out in asymptomatic hypertensive normal-weight men randomly allocated to treatment with atenolol or propranolol. A highly significant increase in the basal plasma triglyceride concentration was observed in propranolol-treated patients after three and six months' treatment, with a smaller but significant increase

J L Day; N Simpson; J Metcalfe; R L Page



HPLC and chemometric-assisted spectrophotometric methods for simultaneous determination of atenolol, amiloride hydrochloride and chlorthalidone  

Microsoft Academic Search

Three methods are presented for the simultaneous determination of atenolol (AT), amiloride hydrochloride (AM) and chlorthalidone (CD). The high performance liquid chromatographic (HPLC) method depends on the separation of each drug on a reversed phase, RP 18 column. Elution was carried out with a mobile phase consisting of acetonitrile -5mM heptansulphonic acid sodium salt (20:80, v\\/v, pH 4.4). Quantitation was achieved

Alaa El-Gindy; Samy Emara; Ahmed Mostafa



The short term effects of propranolol, atenolol and labetalol on antipyrine kinetics in normal subjects.  

PubMed Central

1 The effects of three day courses of propranolol 40 mg three times daily, atenolol 100 mg twice daily and labetalol 100 mg three times daily on antipyrine kinetics were examined in 13 normal subjects. 2 The mean antipyrine clearance initially was 41.3 +/- 12.4 ml/min (mean +/- s.d.) and fell to 35.0 +/- 12.1 ml/min following propranolol (P less than 0.025), 34.5 +/- 9.5 ml/min following atenolol (P less than 0.01), and 35.2 +/- 8.6 ml/min following labetalol (P less than 0.05). 3 The prolongation in antipyrine half-life was significant only following atenolol. Propranolol only caused a significant reduction in the volume of distribution of antipyrine. 4 These adrenoceptor antagonists appear to decrease antipyrine clearance in normal subjects. The reduction in antipyrine clearance was similar with all three drugs and appeared to be independent of the differing lipid solubilities and pharmacological profiles of the adrenoceptor antagonists examined. PMID:7093112

Daneshmend, T K; Roberts, C J



Formulation and optimization of mucoadhesive bilayer buccal tablets of atenolol using simplex design method  

PubMed Central

Introduction: In the present study, mucoadhesive buccal bilayer tablets of atenolol were fabricated with the objective of avoiding first pass metabolism and to improve its bioavailability with reduction in dosing frequency. Hence, the aim of this work was to design oral controlled release mucoadhesive tablets of atenolol and to optimize the drug release profile and bioadhesion. Materials and Methods: Bilayer buccal tablets of atenolol were prepared by direct compression method using simplex method of optimization to investigate the combined effect of hydroxypropyl methylcellulose 15 cps (X1), Carbopol (X2) and mannitol (X3); the in vitro drug release (Y1) and mucoadhesive strength (Y2) were taken as responses. The designed tablets were evaluated for various physical and biological parameters like drug content uniformity, in vitro drug release, short-term stability, and drug- excipient interactions (FTIR). Results: The formulation C containing hydroxypropyl methylcellulose 15 cps (10% w/w of matrix layer), Carbopol 934p (10% w/w of matrix layer) and mannitol (channeling agent, 40% w/w of matrix layer) was found to be promising. This formulation exhibited an in vitro drug release of 89.43% in 9 h along with satisfactory bioadhesion strength (7.20 g). Short-term stability studies on the promising formulation indicated that there are no significant changes in drug content and in vitro dissolution characteristics (P<0.05). IR spectroscopic studies indicated that there are no drug-excipient interactions. PMID:23071958

Shirsand, SB; Suresh, Sarasija; Keshavshetti, GG; Swamy, PV; Reddy, P Vijay Prakash



Antihypertensive effect of captopril, canrenoate potassium, and atenolol. Relations with red blood cell sodium transport and renin.  


We compared the antihypertensive efficacy of atenolol (100 mg/d), canrenoate potassium (200 mg/d), and captopril (75 mg/d) in 30 essential hypertensives. The three drugs were administered in a randomized change-over sequence for four-months each. The main variables associated with blood pressure regulation were measured in the basal condition and at the end of each treatment period. The erythrocyte Na transport systems were measured only in the basal condition and at the end of the first treatment period. The average blood pressure reduction was similar for each drug. Mean blood pressure levels after captopril correlated positively with those after atenolol in the individual patients (P less than 0.0001); mean blood pressure levels after canrenoate potassium, on the contrary, did not correlate with those after the other two drugs. Captopril and canrenoate potassium treatment reduced intraerythrocyte Na content (P less than 0.02), canrenoate potassium increased Na-K pump (P0.05), atenolol did not change any erythrocyte membrane Na transport parameters. The ouabain-resistant Na transport systems were not modified by any drug. The patients were divided in three groups according to their antihypertensive response: nonresponders (six patients), canrenoate potassium responders (nine patients) and captopril-atenolol responders (15 patients, equally responsive to both drugs). Nonresponders had the lowest basal Na pump (P less than 0.02). Canrenoate potassium responders had higher basal Na-K cotransport than captopril-atenolol responders (P less than 0.02). Atenolol-captopril responders had the highest basal plasma renin activity (PRA, P less than 0.02). The blood pressure reduction after atenolol correlated with the induced fall in PRA (P less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS) PMID:3063286

Niutta, E; Cusi, D; Colombo, R; Tripodi, G; Pellizzoni, M; Pati, P; Cesana, B; Alberghini, E; Barlassina, C; Bianchi, G



Study of polymorphism of Atenolol and Captopril antihypertensives using x-ray powder diffraction and Rietveld refinement  

NASA Astrophysics Data System (ADS)

Characterization of bulk drugs has become increasingly important in the pharmaceutical industry. X-ray powder diffractometry is an effective technique for the identification of crystalline solid-phase drugs. The technique is unique, since it combines specificity with a high degree of accuracy for the characterization of pharmaceuticals in solid state and is an especially useful method to describe the possible polymorphic behavior of drugs substances. In this work X-ray diffraction data have been obtained for two well-known antihypertensive drugs currently being administered in tablet form. They include atenolol and captopril. Atenolol and captopril were purchased from drugstore. The characterizations of the atenolol and captopril samples were carried out by FTIR spectroscopy and X-ray powder diffraction (XRPD).

Sato, Juliana; Ferreira, Fabio



Square-wave voltammetric determination of propranolol and atenolol in pharmaceuticals using a boron-doped diamond electrode  

Microsoft Academic Search

The independent determination of two ?-blocker agents, namely propranolol (PROP) and atenolol (ATN), in pharmaceutical formulations using square-wave voltammetry and a cathodically pretreated boron-doped diamond electrode is described. These electroanalytical determinations of propranolol or atenolol were carried out in 0.1molL?1 H2SO4 or 0.5molL?1 NaNO3 (pH 1.0, adjusted with concentrated HNO3), respectively. Excellent linear calibration curves, ranging from 0.20 to 9.0?molL?1

Elen Romão Sartori; Roberta Antigo Medeiros; Romeu C. Rocha-Filho; Orlando Fatibello-Filho



In vitro and in vivo equivalence of two oral atenolol tablet formulations.  


A randomised, cross-over, open study of bioequivalence between two different atenolol (CAS 29122-68-7) tablet formulations is presented. An in vitro comparative study between the two formulations was also performed. Both products meet the USP 23 (United States Pharmacopea) specification. The values of similarity factor (f2) and difference factor (f1) obtained ensure sameness or equivalence of the two dissolution curves. Twenty-four healthy volunteers (male/female) participated in the bioequivalence study. Each treatment was given as a single 100-mg tablet following an overnight fast. Atenolol concentrations in plasma were determined up to 30 h after treatment by HPLC. The pharmacokinetic parameters AUC0-infinity, Cmax and Cmax/AUC0-infinity were tested for bioequivalence after logarithmic transformation of data and ratios of tmax were evaluated nonparametrically. The parametric analysis revealed the following test/reference ratios and their 90% confidence intervals (90% CI): 1.06 (0.99-1.13) for AUC, 1.07 (0.97-1.18) for Cmax, and 0.99 (0.94-1.07) for Cmax/AUC0-infinity. The 90% CI for tmax was 0.91-1.23. All parameters showed bioequivalence between both formulations. A discrete fall in both systolic (SBP) and diastolic (DBP) blood pressure was observed after the drug administration. The fall extent (approximately 11 mmHg in supine position) and the time course of both parameters after the drug administration was similar for both formulations. Minimal values for SBP and DBP were achieved at 6 h after the drug administration for both formulations. Heart rates were also reduced after the administration of both formulations of atenolol in a similar extent (12 b.p.m.) and following a similar time profile (i.e. maximal reductions were observed between 1 and 3 h after the drug administration). It can be concluded that both formulations are equivalent in vitro and in vivo. PMID:12087922

Cuadrado, Antonio; Rodríguez Gascón, Alicia; Hernández, Rose María; Castilla, Ana María; de la Maza, Ane; López de Ocáriz, Alicia; Calvo, Begoña; Pedraz, José Luis



Cardiovascular drugs in human mechanical nociception: digoxin, amlodipine, propranolol, pindolol and atenolol.  


Calcium channel blockers, beta adrenergic receptor blockers and Na/K ATPase inhibitors are widely used drugs, mainly for cardiovascular diseases. Their pharmacological targets are not restricted to the cardivascular tissue, nociceptive system structures also express similar targets, which strongly suggests a direct effect on pain sensation. To evaluate the pain intensity changes in outpatient groups, who receive these drugs as a therapy, a cross-sectional sampled, randomized patient groups receiving the calcium channel blocker amlodipine for blood hypertension (n=45), beta adrenergic receptor blockers (propranolol, atenolol or pindolol; n=40) for blood hypertension, or digoxin (n=40) for heart failure, were compared to an aparently healthy volunteers control group (n=60). A calibrated noxious pressure of 890 g/mm2 was applied for 5 seconds on the patient's sternum. Subjective pain intensity was reported by the visual analog scale (VAS, 0 to 10). Pain modulation system was evaluated by the application of a second stimulus with a 5 minutes delay. The analgesic effect of the beta blockers group (propanolol, atenolol, pindolol) was dosage-dependant (-36.8%; P = 0.0000003), without differences among them. The calcium channel blocker amlodipine showed lower pain scores (-50.6%; P = 0.0000003) than beta-receptor blockers (P = 0.0000003). Digoxin presented the highest pain scores (+56.5%; P = 0.0000003). All pain scores for the second stimulus were lower than the first stimulus and were differentially affected by beta-blockers (atenolol, pindolol and propanolol) and calcium channel blocker (amlodipine), but not by digoxin. These results suggest the influence of widely clinically used cardiovascular drugs on nociception. PMID:20815158

Del Giaccio, Alfredo; Eblen-Zajjur, Antonio



Design of a timed and controlled release osmotic pump system of atenolol.  


Abstract The objective of the article was to design a novel timed and controlled release osmotic pump (TCOP) containing atenolol as an active pharmaceutical ingredient and compare with a bilayer-core osmotic pump (BCOP) of atenolol. Different from BCOP, a modulating barrier was added to delay the drug release and obtain desired lag time (Tlag). The influences of the amount of pore-forming agent and modulating barrier, coating weight gain on the lag time (Tlag) and drug release rate (Rt) of TCOP were investigated. The central composite design-response surface methodology (RSM) was applied to optimize the formulation. Rhodamine B was added to modulating barrier to determine the release process of modulating barrier. A method used to correct the release profiles with a certain lag time by ?Tlag and interpolating was applied to compare TCOP with BCOP. Tlag was directly proportional to the amount of modulating barrier and coating weight gain, but inversely related to the amount of pore forming agent, which were contrary to the effects on Rt. The optimal formulation including 60?mg PEO WSR N80, 3?g PEG 4000 and 6% coating weight gain could obtain a 3.59-h Tlag. According to the release of Rhodamine B, the modulating barrier was completely pushed out at ?5.0?h, longer than 3.59?h, therefore, atenolol along with remaining modulating barrier was released together between 3.59 and 5.0?h. By comparing with BCOP, the release profiles subtracting the part of lag time had no significant difference, yet Rt of TCOP presented a slight decrease. PMID:24796273

Xue, Yingna; Yu, Shihui; Wang, Hanbing; Liang, Jingge; Peng, Junjie; Li, Jiang; Yang, Xinggang; Pan, Weisan



Photochemical degradation of atenolol, carbamazepine, meprobamate, phenytoin and primidone in wastewater effluents.  


The photochemical degradation of five pharmaceuticals was examined in two secondary wastewater effluents. The compounds, which included atenolol, carbamazepine, meprobamate, phenytoin and primidone, were evaluated for both direct and sensitized photolysis. In the two wastewaters, direct photolysis did not lead to significant compound degradation; however, sensitized photolysis was an important removal pathway for the five pharmaceuticals. Upon solar irradiation, hydroxyl radical (HO) was quantified using the hydroxylation of benzene and singlet oxygen ((1)O2) formation was monitored following the degradation of furfuryl alcohol. Degradation via sensitized photolysis was observed following five-day exposures for atenolol (69-91%), carbamazepine (67-98%), meprobamate (16-52%), phenytoin (44-85%), and primidone (34-88%). Varying removal is likely a result of the differences in reactivity with transient oxidants. Averaged steady state HO concentrations ranged from 1.2 to 4.0×10(-16)M, whereas the concentrations of (1)O2 were 6.0-7.6×10(-14)M. Partial removal due to presence of HO indicates it was not the major sink for most compounds examined. Other transient oxidants, such as (1)O2 and triplet state effluent organic matter, are likely to play important roles in fates of these compounds. PMID:24798495

Dong, Mei Mei; Trenholm, Rebecca; Rosario-Ortiz, Fernando L



Ecotoxicity of ketoprofen, diclofenac, atenolol and their photolysis byproducts in zebrafish (Danio rerio).  


The occurrence of pharmaceutical compounds in wastewater treatment plants and surface waters has been detected worldwide, constituting a potential risk for aquatic ecosystems. Adult zebrafish, of both sexes, were exposed to three common pharmaceutical compounds (atenolol, ketoprofen and diclofenac) and their UV photolysis by-products over seven days. The results show that diclofenac was removed to concentrationsatenolol and ketoprofen was reduced after the parent compounds were transformed by photolysis, whereas the toxicity increased significantly from the by-products generated through diclofenac photolysis. Therefore, diclofenac photolysis would possibly necessitate higher irradiation time to ensure that the associated by-products are completely degraded to harmless form(s). PMID:25461029

Diniz, M S; Salgado, R; Pereira, V J; Carvalho, G; Oehmen, A; Reis, M A M; Noronha, J P



Simple and rapid HPLC method for simultaneous determination of atenolol and chlorthalidone in spiked human plasma  

PubMed Central

A simple, sensitive and rapid chromatographic method was developed and validated for the simultaneous quantification of atenolol and chlorthalidone in human plasma using hydrochlorothiazide as internal standard (IS). The method utilized proteins precipitation with acetonitril as the only sample preparation involved prior to reverse phase-HPLC. The analytes were chromatographed on Shim-pack cyanopropyl column with isocratic elution with 10 mM KH2PO4 (pH 6.0) – methanol (70:30, v/v) at ambient temperature with flow rate of 1 mL min?1 and UV detection at 225 nm. The chromatographic run time was less than 10 min for the mixture. The calibration curves were linear over the range of 0.1–10 ?g mL?1. The method was validated in terms of accuracy, precision, absolute recovery, freeze–thaw stability, bench-top stability and re-injection reproducibility. The within- and between-day accuracy and precision were found to be within acceptable limits <15%. The analytes were stable after three freeze–thaw cycles (deviation <15%). The proposed method was specific for the simultaneous determination of atenolol and chlorthalidone in human plasma where there was no interference from endogenous biological substances. PMID:23960741

Elgawish, Mohamed S.; Mostafa, Samia M.; Elshanawane, Abdalla A.



Effects of propranolol and atenolol on immobilization stress-induced hypertension and down-regulation of central ?-adrenoceptors in rats  

Microsoft Academic Search

Effects of chronic treatment with propranolol or atenolol on stress-induced changes in blood pressure, body weight and cerebral ?-adrenoceptors in rats were examined and compared with the effects of chronic treatment with prazosin. Immobilization stress (2 h daily for 2 weeks) induced a moderate elevation of blood pressure, loss of body weight gain and downregulation of cerebral ?-adrenoceptors, but produced

Manabu Takita; Yasuo Oda; Shigeru Kigoshi; Ikunobu Muramatsu



Comparison of Atenolol, Amlodipine, Enalapril, Hydrochlorothiazide, and Losartan for Antihypertensive Treatment in Patients with Obstructive Sleep Apnea  

Microsoft Academic Search

We compared the effects of atenolol (50 mg), amlodipine (5 mg), enalapril (20 mg), hydrochlorothiazide (25 mg), and losartan (50 mg) given in once-daily oral doses on office and ambulatory blood pressures (BPs) in patients with hypertension and obstructive sleep apnea (OSA). Each of 40 randomized patients was treated in se- quence with two of the five agents (balanced incomplete




Effects of doxazosin and atenolol on the fibrinolytic system in patients with hypertension and elevated serum cholesterol  

Microsoft Academic Search

Disturbances in the fibrinolytic system have been associated with cardiovascular disease and its risk factors. In the present study the effects of an alpha1-adrenoceptor inhibitor (doxazosin) and a selective beta-adrenoceptor blocker (atenolol) on the fibrinolytic system have been evaluated.

J.-H. Jansson; B. Johansson; K. Boman; T. K. Nilsson



Spectral and mechanistic investigations of ruthenium(III) catalyzed oxidation of atenolol by diperiodatocuprate(III) in aqueous alkaline medium  

NASA Astrophysics Data System (ADS)

The kinetics of ruthenium(III) catalyzed oxidation of atenolol by diperiodatocuprate(III) in aqueous alkaline medium at a constant ionic strength of I = 0.10 M has been studied spectrophotometrically at 27°C. The reaction between diperiodatocuprate(III) and atenolol in alkaline medium in presence of ruthenium(III) exhibits 2: 1 stoichiometry (atenolol: diperiodatocuprate(III)). The main products were identified by spot test, IR, NMR, and LC-MS. The reaction is of first order in DPC concentrations and has less than unit order in both ATN and alkali concentrations. The order in ruthenium(III) was unity. Intervention of free radicals was observed in the reaction. Increase in periodate concentration decreases the rate. The oxidation reaction in alkaline medium has been shown to proceed via a ruthenium(III)-atenolol complex, which reacts with monoperiodatocuprate(III) in a rate determining step followed by other fast steps to give the products. Probable mechanism is proposed and discussed. The activation parameters with respect to the slow step of the mechanism and thermodynamic quantities were determined and discussed.

Patil, R. K.; Nandibewoor, S. T.; Chimatadar, S. A.



Induction of insulin resistance by beta-blockade but not ACE-inhibition: long-term treatment with atenolol or trandolapril  

Microsoft Academic Search

The effects on glucose metabolism by the beta-blocker atenolol and the angiotensin-converting enzyme (ACE)-inhibitor trandolapril were investigated in a randomised double-blind parallel group study of patients with primary hypertension. Twenty-six patients were treated with 50–100 mg atenolol and 27 patients with 2–4 mg trandolapril o.d. Intravenous glucose tolerance tests, euglycaemic hyperinsulinaemic clamps and serum lipid measurements were performed after 8

R Reneland; E Alvarez; P-E Andersson; A Haenni; L Byberg; H Lithell



Spectroscopic and DFT study of atenolol and metoprolol and their copper complexes  

NASA Astrophysics Data System (ADS)

IR, Raman and surface-enhanced Raman scattering (SERS) spectra of atenolol (ATE) and metoprolol (MET) were recorded and assigned on the basis of density functional theory (DFT) calculations. A reliable assignment of vibrational IR and Raman bands of the two compounds was possible by a proper choice of models used in quantum chemical calculations. Both molecules are adsorbed to the silver surface mainly through the oxygen atoms and ?-electrons of the phenyl ring. The coordination mode of the metal ions in Cu(II)-ATE and -MET compounds was also derived from IR and EPR spectra. EPR spectra give evidence for a square-planar arrangement around the copper (II) ion in the case of Cu-ATE complex, with a N 2O 2 chromophore. Only oxygen atoms are involved in the cooper coordination for Cu-MET complex, and two types of local symmetries with d and d as ground states for paramagnetic electron coexist.

Cozar, O.; Szabó, L.; Cozar, I. B.; Leopold, N.; David, L.; C?inap, C.; Chi?, V.



HPLC and chemometric-assisted spectrophotometric methods for simultaneous determination of atenolol, amiloride hydrochloride and chlorthalidone.  


Three methods are presented for the simultaneous determination of atenolol (AT), amiloride hydrochloride (AM) and chlorthalidone (CD). The high performance liquid chromatographic (HPLC) method depends on the separation of each drug on a reversed phase, RP (18) column. Elution was carried out with a mobile phase consisting of acetonitrile -5mM heptansulphonic acid sodium salt (20:80, v/v, pH 4.4). Quantitation was achieved with UV detection at 274 nm based on peak area. The other two-chemometric-assisted spectrophotometric methods applied were principal component regression (PCR) and partial least squares (PLS-1). These approaches were successfully applied to quantify each drug in the mixture using the information included in the absorption spectra of appropriate solutions in the range 240-290 nm with the intervals Deltalambda=0.2 nm. The three methods were successfully applied to a pharmaceutical formulation (tablets), and the results were compared with each other. PMID:15784248

El-Gindy, Alaa; Emara, Samy; Mostafa, Ahmed



Simultaneous spectrophotometric estimation of Hydrochlorothiazide, Atenolol and Losartan potassium in tablet dosage form.  


Two simple, accurate and reproducible spectrophotometric methods have been developed for the simultaneous estimation of Hydrochlorothiazide (Hctz), Atenolol (Atn) and Losartan potassium (Los) in combined tablet dosage forms. The first method involves determination using the simultaneous equation method, the sampling wavelengths selected are, 272.5 nm, 224 nm and 250 nm over the concentration ranges of 0.5-30 microg/ml, 1-50 microg/ ml and 1-60 microg/ml for Hctz, Atn and Los respectively. The second method is the First order derivative method, the sampling wavelengths selected for estimation of Hctz, Atn and Los are 280.5 nm, 233 nm and 244 nm with linearity in the concentration ranges of 0.5-30 microg/ ml, 1-50 microg/ml and 1-60 microg/ml respectively. The results of the analysis were validated statistically and recovery studies were carried out as per ICH guidelines. PMID:21268558

Thomas, Asha B; Chavan, Umesh B; Nanda, Rabindra K; Kothapalli, Lata P; Deshpande, Avinash D; Jagdale, Sheetal N; Dighe, Shweta B



Atenolol improves ventricular function without changing plasma noradrenaline but decreasing plasma atrial natriuretic factor in chronic heart failure.  


1 There is good evidence that beta-blockers improve ventricular function, disease progression and survival in patients with left ventricular systolic dysfunction. The aim of this study was to determine the effects of atenolol therapy on the sympathetic nervous system at rest and after ergometric exercise, on left ventricular function and on baseline plasma atrial natriuretic factor (ANF) in ambulatory patients with chronic heart failure (CHF). 2 Twenty-two patients [left ventricular ejection fraction (LVEF) <36%; New York Heart Association II-III] were studied before atenolol treatment. Because of cardiac events (new Hospital admission or death) only 13 patients completed 1 year of treatment. Baseline noradrenaline (NE) concentrations were similar in patients and controls while ANF was higher in patients than in controls (328 +/- 35 pg ml(-1) vs. 37 +/- 3 pg ml(-1); P<0.01). 3 Patients with events showed higher NE (540 +/- 87 pg ml(-1) vs. 303 +/- 44 pg ml(-1); P<0.01) and ANF (460 +/- 70 pg ml(-1) vs. 291 +/- 44 pg ml(-1); P<0.03) at rest; and greater NE response to exercise (2.003 +/- 525 pg ml(-1) vs. 694 +/- 121 pg ml(-1); P<0.005). Atenolol treatment improved LVEF (19.5 +/- 1.9% vs. 33 +/- 3.9%; P<0.001), increased exercise tolerance (9 +/- 3.2 min vs. 17 +/- 4.8 min; P<0.001) and decreased plasma ANF (292 +/- 42 pg ml(-1) vs. 133 +/- 35 pg ml(-1); P<0.01). 4 Reduced basal dihydroxyphenylglycol (DHPG)/NE ratio (3.4 +/- 0.46 vs. 4.3 +/- 0.35; P<0.01) was observed in patients compared with healthy volunteers. Atenolol increased DHPG plasma levels (1.398 +/- 129 pg ml(-1) vs. 913 +/- 86 pg ml(-1); P<0.005) but the DHPG/NE ratio during exercise was not modified after treatment, suggesting that re-uptake of released NE is not changed by beta-blocker treatment. 5 In conclusion, the fact that atenolol treatment improves ventricular dysfunction and clinical status without changing plasma NE levels in CHF patients, suggests that plasma NE is a poor surrogate measurement for cardiac sympathetic activity in this pathology. In addition, decrease in plasma ANF produced by atenolol treatment may reflect the improvement of ventricular function. PMID:12866806

Gabrielli, O; Puyó, A M; De Rosa, A; Armando, I; Barontini, M; Levin, G



Electrochemical investigation of atenolol oxidation and detection by using a multicomponent nanostructural assembly of amino acids and gold nanoparticles  

NASA Astrophysics Data System (ADS)

A novel nanostructured assembly based on poly(glutamic) acid/cysteine/gold nanoparticles was designed to modify the surface of a glassy carbon electrode (GCE) and used to study the atenolol oxidation. The GCE surface was initially covered by poly(glutamic) acid/cysteine layers followed by covalent attachment of citrate-capped 40 nm-AuNPs. The system excellent electrochemical performance was tested by Linear Sweep Voltammetry and Electrochemical Impedance Spectroscopy and allowed the detection of an atenolol oxidation peak (around +0.65 V/SCE) with a detection limit of 3.9 × 10-7 M. Such findings could be incorporated in highly sensitive detection technologies of various biological or chemical compounds and molecules.

Pruneanu, Stela; Pogacean, Florina; Grosan, Camelia; Pica, Elena Maria; Bolundut, Liviu Calin; Biris, Alexandru Sorin



Spectroscopic investigations and crystal structure from synchrotron powder data of the inclusion complex of ?-cyclodextrin with atenolol  

NASA Astrophysics Data System (ADS)

Inclusion complexes of atenolol with ?-cyclodextrin (?-CD) in aqueous solution have been investigated with 1H NMR and UV-vis spectroscopy. The stoichiometry of this inclusion complex was established to be equimolar (1:1) and its stability constant was determined by UV-vis spectroscopy. The crystal structure of the ?-CD-atenolol (1:1) inclusion compound has been solved from synchrotron powder diffraction data using direct-space search techniques. The crystal structure model and 1H NMR data are in good agreement and, with support of Hyperchem MM+ molecular dynamics results, suggest which protons are likely to be involved in the inclusion process that leads to the supramolecular architecture of this guest-host complex.

Borodi, Gheorghe; Bratu, Ioan; Dragan, Felicia; Peschar, René; Helmholdt, Robert B.; Hernanz, Antonio



Effect of b1 blockade with atenolol on progression of heart failure in patients pretreated with high-dose enalapril  

Microsoft Academic Search

Background: The survival benefit of b-blocker treatment in patients with heart failure has been established in recent trials. Yet, the impact of b-blockers added on high dose angiotensin converting enzyme inhibitors has not been reported. Aims: To investigate the effect of atenolol, a hydrophilic, selective b1-adrenergic antagonist, added on enalapril 40 mgrday in patients with advanced left ventricular dysfunction in

Barbara Sturm; Richard Pacher; Jeanette Strametz-Juranek; Rudolf Berger; Bernhard Frey; Brigitte StanekU



Differential effects of enalapril and atenolol on proteinuria and renal haemodynamics in non-diabetic renal disease  

Microsoft Academic Search

OBJECTIVE--To compare the antihypertensive, renal haemodynamic and antiproteinuric effect of enalapril and atenolol in patients with proteinuria of non-diabetic origin. DESIGN--Prospective, double blind, randomised 16 week study after a pretreatment period of at least three weeks. SETTING--Outpatient nephrology and hypertension unit. PATIENTS--27 patients with proteinuria (greater than 300 mg protein\\/day) of non-diabetic origin, moderately impaired renal function (creatinine clearance 30-90

A J Apperloo; D de Zeeuw; H E Sluiter; P E de Jong



Regression of Electrocardiographic Left Ventricular Hypertrophy by Losartan Versus Atenolol The Losartan Intervention For Endpoint reduction in hypertension (LIFE) Study  

Microsoft Academic Search

Background—Electrocardiographic left ventricular hypertrophy (LVH) predicts cardiovascular morbidity and mortality, and regression of ECG LVH may predict improved prognosis in hypertensive patients. However, uncertainty persists as to how best to regress ECG LVH. Methods and Results—Regression of ECG LVH with losartan versus atenolol therapy was assessed in 9193 hypertensive patients with ECG LVH by Sokolow-Lyon voltage or Cornell voltage-duration product

Peter M. Okin; Richard B. Devereux; Sverker Jern; Sverre E. Kjeldsen; Stevo Julius; Markku S. Nieminen; Steven Snapinn; Katherine E. Harris; Peter Aurup; Jonathan M. Edelman; Björn Dahlöf



COD reduction of waste water streams of active pharmaceutical ingredient – Atenolol manufacturing unit by advanced oxidation-Fenton process  

Microsoft Academic Search

Active pharmaceutical intermediates (API) in waste waters have adverse effects on aquatic life and environment. The API have high COD value and low BOD3 and hence difficult to treat biologically. In this study, advanced oxidation processes (AOPs) utilizing the H2O2\\/Fe+2, Fenton reactions were investigated in lab-scale experiments for the degradation of Atenolol containing waste water streams. The experimental results showed

Sayyed Hussain; Shahid Shaikh; Mazahar Farooqui


Comparison of two long-acting preparations of metoprolol with conventional metoprolol and atenolol in healthy men during chronic dosing.  

PubMed Central

1 Eight healthy men received two long-acting formulations of metoprolol 200 mg (SA Astra, SR Geigy), conventional metoprolol 200 mg and atenolol 100 mg once daily for 1 week each in balanced, crossover fashion. There was a washout period of at least a week between each phase. 2 On the last day of each phase, post-exercise heart rate was recorded at intervals and compared to pretreatment values. Plasma metoprolol concentrations were measured. 3 The mean AUC was similar after each of the three formulations of metoprolol (relative bioavailability of SA and SR v conventional was 97%) but with SA and SR metoprolol the time to peak was significantly delayed by about 2 h. 4 In comparison to conventional metoprolol only metoprolol SA was associated with significantly higher plasma metoprolol concentrations at the end of a dosing interval (mean values: conventional, 25 ng/ml, SR 37 ng/ml, SA 51 ng/ml). 5 Mean (+/- s.d.) reduction in exercise tachycardia at the end of a dosing interval was significantly greater with atenolol (14.8 +/- 4.5%) and metoprolol SA (13.7 +/- 10.3%) than with metoprolol SR (10 +/- 8.4%) and conventional metoprolol (8.2 +/- 7.1%). 6 The variability in beta-adrenoceptor blockade at 24 h was much greater with each of the three metoprolol formulations than that with atenolol. This was explained by the variability in metoprolol metabolism. 7 Oxidation phenotype testing with debrisoquine showed there were six extensive metabolisers and two poor metabolisers. The AUC, half-life and response to metoprolol at 24 h were much greater in poor metabolisers. Response to atenolol was not influenced by phenotype. PMID:7138751

Freestone, S; Silas, J H; Lennard, M S; Ramsay, L E



Titrimetric, spectrophotometric and kinetic methods for the as- say of atenolol using bromate-bromide and methyl orange  

Microsoft Academic Search

Three new methods have been developed for the determination of atenolol in bulk drug and in tablet formulation. The methods are based on the oxidation-bromina- tion reaction of the drug by bromine, generated in situ by the action of acid on ab ro- mate-bromide mixture. In the titrimetric method, the drug is treated with a known ex- cess of bromate-bromide



Oxidative degradation and deamination of atenolol by diperiodatocuprate(III) in aqueous alkaline medium: A mechanistic study  

Microsoft Academic Search

The kinetics of oxidation of atenolol (ATN) by diperiodatocuprate(III) (DPC) in aqueous alkaline medium at a constant ionic strength of 0.10moldm?3 was studied spectrophotometrically. The reaction between DPC and ATN in alkaline medium exhibits 1:2 stoichiometry (ATN:DPC). The reaction is of first order in [DPC] and has less than unit order in both [ATN] and [alkali]. However, the order in

Rajesh N. Hegde; Nagaraj P. Shetti; Sharanappa T. Nandibewoor



A Stability-indicating High Performance Liquid Chromatographic Assay for the Simultaneous Determination of Atenolol and Lercanidipine Hydrochloride in Tablets  

PubMed Central

A simple, rapid, precise and accurate isocratic reversed phase stability indicating HPLC method was developed and validated for the simultaneous determination of atenolol and lercanidipine hydrochloride in commercial tablets. The chromatographic separation was achieved on phenomenex Gemini C18 (250×4.6 mm, 5 ?m) column using a mobile phase consisting of acetonitrile and buffer (20 mM potassium dihydrogen phosphate pH 3.5) in the ratio of (55:45, v/v) at a flow rate of 1.0 ml/min and UV detection at 235 nm. The linearity of the proposed method was investigated in the range of 40-160 ?g/ml (r2=0.9995) for atenolol and 8-32 ?g/ml (r2=0.9993) for lercanidipine. Degradation products produced as a result of stress studies did not interfere with the detection of atenolol and lercanidipine and the assay can thus be considered stability-indicating. PMID:22707819

Kaila, H. O.; Ambasana, M. A.; Thakkar, R. S.; Saravaia, H. T.; Shah, A. K.



A comparison of sustained release verapamil versus atenolol for 24 h protection from exercise-induced angina pectoris.  


We have compared the efficacy of a once daily 360 mg sustained release preparation of verapamil (SRV) with that of once daily 100 mg atenolol in exercise-induced angina. The study was randomized, double-blind and cross-over in design involving 30 patients with chronic stable angina. A 2-week run-in placebo phase was followed by two 4-week periods of active treatment. Patients underwent exercise stress tests at 6 and 24 h post-dose at the end of each treatment phase. After the placebo phase, patients had significantly increased times to both 1 mm ST depression and angina at 6 h (afternoon stress test) compared to 24 h post-dose (morning test). The two treatments were found to be equivalent in terms of several indices of anti-anginal efficacy. The only significant differences between treatments were in relation to indices of heart rate, which were consistently lower with atenolol than with SRV. We conclude that once daily sustained release verapamil 360 mg has equivalent anti-anginal efficacy to once daily atenolol 100 mg. A lower angina threshold seems to occur in the morning in patients with ischaemic heart disease suggesting a diurnal variation. PMID:1778191

Hopkinson, N D; Hui, K P; Smith, M P; Hollinrake, K



Formulation and Evaluation of Fixed-Dose Combination of Bilayer Gastroretentive Matrix Tablet Containing Atorvastatin as Fast-Release and Atenolol as Sustained-Release  

PubMed Central

The objective of the present study was to develop bilayer tablets of atorvastatin and atenolol that are characterized by initial fast-release of atorvastatin in the stomach and comply with the release requirements of sustained-release of atenolol. An amorphous, solvent evaporation inclusion complex of atorvastatin with ?-cyclodextrin, present in 1?:?3 (drug/cyclodextrin) molar ratio, was employed in the fast-release layer to enhance the dissolution of atorvastatin. Xanthan gum and guar gum were integrated in the sustained-release layer. Bilayer tablets composed of sustained-release layer (10% w/w of xanthan gum and guar gum) and fast-release layer [1?:?3 (drug/cyclodextrin)] showed the desired release profile. The atorvastatin contained in the fast-release layer showed an initial fast-release of more than 60% of its drug content within 2?h, followed by sustained release of the atenolol for a period of 12?h. The pharmacokinetic study illustrated that the fast absorption and increased oral bioavailability of atorvastatin as well as therapeutic concentration of atenolol in blood were made available through adoption of formulation strategy of bilayer tablets. It can be concluded that the bilayer tablets of atorvastatin and atenolol can be successfully employed for the treatment of hypertension and hypercholesterolemia together through oral administration of single tablet. PMID:24527446

Dey, Sanjay; Chattopadhyay, Sankha; Mazumder, Bhaskar



The role of dissolved organic matters in the aquatic photodegradation of atenolol.  


Atenolol (ATL) is a photostable and hydrolysis resistant beta-blocker and has been frequently detected in natural water. In this study, mechanism on aquatic photodegradation of ATL was investigated with an emphasis on the role of dissolved organic matters (DOMs) as well as other natural water compositions (nitrate, bicarbonate and ferric ions). Significant acceleration of photodegradtion of ATL was observed in the presence of each DOMs added, namely Suwannee River Fulvic Acid (SRFA), Suwannee River Humic Acid (SRHA), Nordic Lake Fulvic Acid (NOFA) and Nordic Lake Humic Acid (NOHA). Hydroxyl radical (•OH) was determined as the main reactive species in this process, instead of singlet oxygen or excited triplet of DOM. Addition of these four DOMs all inhibited photodegradation of ATL in nitrate solutions through reducing nitrated-derived •OH and screening photons absorbed by nitrate. No loss of ATL was detected in bicarbonate solution with or without DOMs. Bicarbonate exhibited a scavenger of •OH derived from DOMs. However, in the presence of iron species, photodegradation of ATL was significantly enhanced by the addition of each DOM, due to the high yield of •OH in the photoprocess of Fe(III)-DOM complex. The photoproducts distribution of ATL demonstrated that SRFA promote the hydroxylation on aromatic ring in the presence of nitrate and reduce the ketone moiety to alcohol in the system of ferric ions. Our findings indicate that DOMs should be considered in aquatic photoprocesses of organic pollutants induced by themselves as well as other coexisting photoactive water compositions. PMID:23017239

Zeng, Chao; Ji, Yuefei; Zhou, Lei; Zhang, Ya; Yang, Xi



Cardiovascular and pharmacokinetic interactions between nicorandil and adjunctive propranolol, atenolol or diltiazem in conscious dogs.  


In support of clinical antianginal studies, the vasodilator nicorandil (NIC) was combined with the beta-adrenergic receptor antagonists propranolol (PRO) and atenolol (ATN) and with the calcium channel blocker diltiazem (DTZ) to determine their cardiovascular and pharmacokinetic interactions. Beagle dogs were chronically cannulated to record mean arterial pressure, heart rate, and the lead II electrocardiogram under conscious conditions. Oral NIC (1, 3, and 10 mg/kg) was coadministered with i.v. PRO (5.0 mg/kg) or ATN (7.5 mg/kg), both of which lessened NIC's reflex tachycardia. ECG rhythm remained normal, but both beta-blockers restricted high dose NIC's QTc prolongation and ST segment depression. Intravenous DTZ (5-23 micrograms/kg/min) did not affect i.v. NIC's hypotensive profile (10-80 micrograms/kg/min) but attenuated its tachycardia, whereas NIC-reversed DTZ's PR interval shortening and frequency of ectopic beats. Similar cardiovascular interactions were seen with chronic oral DTZ (10 mg/kg/day) + NIC (3.0 or 7.5 mg/kg). Plasma analysis confirmed that none of the adjuncts affected NIC's disposition nor its concentration-dependent hypotensive response profile. These studies establish the cardiovascular effects of NIC when combined with PRO, ATN or DTZ in dogs, and outline paradigms useful for evaluating such antianginal drug combinations. PMID:10022032

Humphrey, S J



Desenvolvimento, aplicação e avaliação de um modelo de intervenção positiva para pacientes com miastenia gravis.  

E-print Network

??Essa dissertação objetiva desenvolver, aplicar e avaliar um modelo de intervenção psicológica em grupo baseado nas abordagens cognitivo-comportamental e positiva para pacientes com miastenia gravis.… (more)

Bruna Larissa Seibel



Photo-Fenton decomposition of ?-blockers atenolol and metoprolol; study and optimization of system parameters and identification of intermediates.  


Active pharmaceutical compounds reach the wastewater treatment plants mainly through excretion and improper disposal, and, because of insufficient treating methods, they end up to surface water or even potable water in some cases. Atenolol and metoprolol are ?-blockers, members of cardiovascular pharmaceuticals group. They are generally used in the treatment of disorders such as hypertension, angina and arrhythmias. They have been in long-term use in Europe and North America, and they have also been detected in the aquatic environment. In this study the degradation of atenolol and metoprolol in aqueous solutions by means of the photo-Fenton reaction was investigated. The purpose of this study was: (i) to investigate the influence of the concentrations of iron and hydrogen peroxide, by means of central composite design, (ii) to study the degradation kinetics in aqueous solutions, (iii) to evaluate the mineralization and the toxicity evolution of the target compounds and (iv) to identify the degradation products. It has been found that increase of iron and hydrogen peroxide concentration accelerate the degradation of atenolol and metoprolol, while the kinetics of the process can be characterized as pseudo-first order. In general the photo-Fenton method has proved to be effective in decomposing and mineralizing the target compounds. The determination of the by-products formed during the degradation using LC-MS/MS equipment and the evaluation of the toxicity of the treated solution in different stages of the process would offer significant, innovative information regarding the treatment of water and wastewater containing active pharmaceutical compounds, especially of the ?-blocker group. PMID:24589299

Veloutsou, S; Bizani, E; Fytianos, K



Hemodynamic effects of nifedipine given alone and in combination with atenolol in patients with impaired left ventricular function  

SciTech Connect

The acute intravenous (IV) (0.1, 0.2 and 0.4 microgram/kg/min over 10 minutes each) and chronic oral (60 mg/day) administration of nifedipine was examined in 9 patients with significantly impaired left ventricular (LV) function (ejection fraction (EF) on radionuclide scanning was 0.20 to 0.40) who were already receiving beta-blocker therapy (greater than 25% reduction in peak exercise heart rate) with atenolol, 100 to 200 mg/day. The mean control LV end-diastolic pressure (EDP) at cardiac catheterization and EF for the group as a whole were 30 +/- 3 mm Hg (range 20 to 42) (mean +/- standard error of the mean) and 28.5 +/- 2.4%, respectively. Three of the 9 patients had hemodynamic deterioration and LV failure at some stage during the study, and their mean LVEDP and EF were 38 +/- 3 mm Hg (range 33 to 42) and 22.6 +/- 2.7%, respectively. In the 6 patients who tolerated the full treatment protocol, the mean LVEDP and EF were 26.5 +/- 2.0 mm Hg (range 20 to 35) and 31.5 +/- 2.8%, respectively. Seven patients received IV nifedipine, which had a negative inotropic action but did not precipitate cardiac decompensation. Chronic oral administration of nifedipine in combination with atenolol precipitated LV failure only in those with the lowest EF and highest LVEDP; usually LV failure was present with atenolol alone. Extensive infarction, frequently complicated by LV failure at the time, LVEDP greater than 32 mm Hg and control resting EF less than 30% were associated with LV failure.

de Buitleir, M.; Rowland, E.; Krikler, D.M.



Comparison of the beta-adrenoceptor affinity and selectivity of cetamolol, atenolol, betaxolol, and ICI-118,551.  


The objective of the present study was to compare the quantitative differences in the beta 1- vs. beta 2-adrenoceptor affinity and selectivity of cetamolol and its enantiomers to the reference compounds atenolol, betaxolol, and ICI-118,551, using isolated tissues obtained from the dog, guinea pig, and rat. Cetamolol antagonized the beta-adrenoceptor-mediated responses induced by isoproterenol, epinephrine, norepinephrine, and salbutamol, in tissues from both the dog and guinea pig, in a concentration-dependent manner. For a given tissue, the beta-adrenoceptor antagonist activity of cetamolol (measured as a pA2 or pKB value) was independent of the agonist used. In the dog tissues, cetamolol was more potent at inhibiting responses in the coronary artery (beta 1-adrenoceptors) than in the saphenous vein (beta 2-adrenoceptors). In the guinea pig tissues, the potency of cetamolol was approximately the same in the trachea (mixed beta 1- and beta 2-adrenoceptors) and atria (predominately beta 1-adrenoceptors), but lower in the soleus muscle (beta 2-adrenoceptors). Studies with the S-(-) and R-(+) enantiomers of cetamolol demonstrated that the S-(-) enantiomer was approximately 100-fold more potent at beta 1-adrenoceptors than the R-(+) enantiomer. In rat brain, cetamolol displaced [3H]-dihydroalprenolol bound to homogenates of cortex (beta 1-adrenoceptor binding sites) and cerebellum (beta 2-adrenoceptor binding sites). The potency of cetamolol at beta 1-adrenoceptors was found to be similar to that of betaxolol but greater than that of atenolol. However, the magnitude of the beta 1-adrenoceptor selectivity displayed by atenolol and betaxolol was greater than that displayed by cetamolol. In contrast, ICI-118,551 was found to possess potent and selective affinity for beta 2-adrenoceptors. PMID:2459552

Rimele, T J; Henry, D E; Giesa, F R; Buckley, S K; Geiger, G; Heaslip, R J; Lee, D K; Grimes, D



Venlafaxine and atenolol disrupt epinephrine-stimulated glucose production in rainbow trout hepatocytes.  


The beta-blocker atenolol (ATEN), and the selective serotonin and norepinephrine reuptake inhibitor, venlafaxine (VEN) are found in municipal wastewater effluents, but little is known about the effect of these pharmaceuticals on aquatic animals. We tested the hypothesis that VEN and ATEN disrupt acute stress mediated glucose production in fish liver. To this end, rainbow trout (Oncorhynchus mykiss) hepatocytes were exposed in vitro to different concentrations (0, 0.1, 10, 1000 nM) of VEN or ATEN and glucose production in response to either cortisol or epinephrine (two key stress hormones) was ascertained. Both VEN and ATEN did not affect either the unstimulated or cortisol (100 ng/mL)-stimulated glucose release over a 24 h period. The acute (3 h) unstimulated glucose production by isolated hepatocytes in suspension was also not modified by ATEN, while VEN (100 and 1000 nM) reduced basal glucose release. However, ATEN, even at concentration as low as 0.01 nM completely abolished epinephrine (1 ?M)-induced glucose production in trout hepatocytes. Interestingly, VEN also suppressed epinephrine-induced glucose production but only at higher concentrations (100 and 1000 nM). Neither VEN nor ATEN significantly impacted the glucose production in response to either 8-bromo-cAMP (cAMP analogue) or glucagon (a metabolic hormone that increases glucose production) stimulation. ATEN but not VEN attenuated the epinephrine-induced increase in glucose transporter 2 (GLUT2) mRNA abundance in trout hepatocytes. Taken together, our results suggest that the impact of ATEN and VEN on glucose production involves inhibition of ?-adrenoceptor signaling in trout hepatocytes. Overall, VEN and ATEN are beta-blockers and may disrupt the adaptive acute glucose response to a secondary stressor in rainbow trout. PMID:22057255

Ings, J S; George, N; Peter, M C S; Servos, M R; Vijayan, M M



Lisinopril reduces postexercise albuminuria more effectively than atenolol in primary hypertension.  


Physical exercise causes transient albuminuria. The mechanisms of postexercise albuminuria are not fully clarified but stimulation of the reninangiotensin system (RAS) probably plays a major role through intrarenal haemodynamic changes causing an elevated filtration pressure. In a randomised, double-blind, crossover study we compared the effects on urinary albumin excretion (UAE) of lisinopril (L) and atenolol (A) therapy, i.e. we aimed to investigate whether inhibition of the RAS or inhibition of beta1-adrenoceptor-mediated effects of the sympathetic nervous system differed with regard to changes in UAE. Sixteen patients with uncomplicated primary hypertension were studied. Four standardised bicycle ergometer exercise tests were performed, before and after each active treatment period. UAE 30 min postexercise, determined by radioimmunoassay, was significantly lowered by both treatments: -278 mu g center dot min-1 (L) and -199 mu g center dot min-1 (A). The reduction of postexercise UAE achieved by treatment with the angiotensin-converting enzyme (ACE) inhibitor (L) was significantly greater than that achieved by the beta1-selective adrenoceptor blocker treatment. Blood pressure (BP) at rest and during exercise were equally reduced by both drugs. In conclusion, this study showed that antihypertensive treatment with an ACE inhibitor was more effective in reducing exercise-induced albuminuria than a beta1-selective adrenoceptor-blocking agent with a similar degree of BP reduction in patients with uncomplicated primary hypertension. This suggests that the RAS plays a major role in postexercise albuminuria in hypertensive subjects. The clinical significance of this finding, however, remains to be clarified. PMID:8857071

Rangemark, C; Lind, H; Lindholm, L; Hedner, T; Samuelsson, O



Square-wave voltammetric determination of propranolol and atenolol in pharmaceuticals using a boron-doped diamond electrode.  


The independent determination of two beta-blocker agents, namely propranolol (PROP) and atenolol (ATN), in pharmaceutical formulations using square-wave voltammetry and a cathodically pretreated boron-doped diamond electrode is described. These electroanalytical determinations of propranolol or atenolol were carried out in 0.1molL(-1) H(2)SO(4) or 0.5molL(-1) NaNO(3) (pH 1.0, adjusted with concentrated HNO(3)), respectively. Excellent linear calibration curves, ranging from 0.20 to 9.0micromolL(-1) for PROP and from 2.0 to 41micromolL(-1) for ATN, with detection limits of 0.18 and 0.93micromolL(-1), respectively, were obtained. The obtained recoveries range from 93.9% to 105.0%, for PROP, and from 92.5% to 106.0%, for ATN. The proposed method was successfully applied in the determination of both beta-blockers in several pharmaceutical formulations (tablets), with results in close agreement at a 95% confidence level with those obtained using official spectrophotometric methods. PMID:20441917

Sartori, Elen Romão; Medeiros, Roberta Antigo; Rocha-Filho, Romeu C; Fatibello-Filho, Orlando



Biowaiver monographs for immediate release solid oral dosage forms based on biopharmaceutics classification system (BCS) literature data: Verapamil hydrochloride, propranolol hydrochloride, and atenolol  

Microsoft Academic Search

Literature data related to the Biopharmaceutics Classification System (BCS) are presented on verapamil hydrochloride, propranolol hydrochloride, and atenolol in the form of BCS-monographs. Data on the qualitative composition of immediate release (IR) tablets containing these active substances with a Marketing Authorization (MA) in the Netherlands (NL) are also provided; in view of these MA's the assumptionwasmadethatthesetabletswerebioequivalenttotheinnovatorproduct.The

H. Vogelpoel; J. Welink; G. L. Amidon; H. E. Junginger; K. K. Midha; M. Olling; V. P. Shah; D. M. Barends



Cardiovascular morbidity and mortality in patients with diabetes in the losartan intervention for endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol  

Microsoft Academic Search

Summary Background The most suitable antihypertensive drug to reduce the risk of cardiovascular disease in patients with hypertension and diabetes is unclear. In prespecified analyses, we compared the effects of losartan and atenolol on cardiovascular morbidity and mortality in diabetic patients. Methods As part of the LIFE study, in a double-masked, randomised, parallel-group trial, we assigned a group of 1195

Lars H Lindholm; Hans Ibsen; B. Dahof



Regression of hypertensive left ventricular hypertrophy by losartan compared with atenolol. The Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) Trial  

Microsoft Academic Search

Background—An echocardiographic substudy of the Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) trial was designed to test the ability of losartan to reduce left ventricular (LV) mass more than atenolol. Methods and Results—A total of 960 patients with essential hypertension and LV hypertrophy (LVH) on screening ECG were enrolled at centers in 7 countries and studied by echocardiography at

Richard B. Devereux; B. Dahlof; Eva Gerdts



Randomized double-blind, placebo-controlled trial of oral atenolol in patients with unexplained syncope and positive upright tilt table test results  

Microsoft Academic Search

The objective of this investigation was the assessment of the response rate of oral atenolol in patients with vasovagal syncope after 1 month of treatment. We randomized into two groups all patients referred to our unit who had had at least one episode of syncope or two episodes of presyncope 1 month before presentation and had a positive isuprel Tilt

Nithi Mahanonda; Kiertijai Bhuripanyo; Charuwan Kangkagate; Kanchana Wansanit; Bang-on Kulchot; Koonlawee Nademanee; Suphachai Chaithiraphan



Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behavior, without changing mice longevity  

PubMed Central

The membrane fatty acid unsaturation hypothesis of aging and longevity is experimentally tested for the first time in mammals. Lifelong treatment of mice with the ?1-blocker atenolol increased the amount of the extracellular-signal-regulated kinase signaling protein and successfully decreased one of the two traits appropriately correlating with animal longevity, the membrane fatty acid unsaturation degree of cardiac and skeletal muscle mitochondria, changing their lipid profile toward that present in much more longer-lived mammals. This was mainly due to decreases in 22:6n-3 and increases in 18:1n-9 fatty acids. The atenolol treatment also lowered visceral adiposity (by 24%), decreased mitochondrial protein oxidative, glycoxidative, and lipoxidative damage in both organs, and lowered oxidative damage in heart mitochondrial DNA. Atenolol also improved various immune (chemotaxis and natural killer activities) and behavioral functions (equilibrium, motor coordination, and muscular vigor). It also totally or partially prevented the aging-related detrimental changes observed in mitochondrial membrane unsaturation, protein oxidative modifications, and immune and behavioral functions, without changing longevity. The controls reached 3.93 years of age, a substantially higher maximum longevity than the best previously described for this strain (3.0 years). Side effects of the drug could have masked a likely lowering of the endogenous aging rate induced by the decrease in membrane fatty acid unsaturation. We conclude that it is atenolol that failed to increase longevity, and likely not the decrease in membrane unsaturation induced by the drug. PMID:24612513

Gómez, Alexia; Sánchez-Roman, Ines; Gomez, Jose; Cruces, Julia; Mate, Ianire; Lopez-Torres, Mónica; Naudi, Alba; Portero-Otin, Manuel; Pamplona, Reinald; De la Fuente, Monica; Barja, Gustavo



Effects of atenolol, doxazosin, and enalapril on measures of insulin metabolic syndrome and cardiovascular function at rest and in response to stress in hypertension  

Microsoft Academic Search

The purpose of the current investigation was to gain a clearer understanding of the cardiovascular changes which occur as treatment effects of doxazosin, atenolol and enalapril. A randomized, double blinded crossover design with a placebo condition was used in this design. Assessment of cardiac output (Q), total peripheral resistance (TPR), and the contractility estimate Heather Index (HI) were examined in

Carol K. Gallaher



Excimer formation in inclusion complexes of ?-cyclodextrin with salbutamol, sotalol and atenolol: Spectral and molecular modeling studies  

NASA Astrophysics Data System (ADS)

The inclusion complexation behavior of salbutamol, sotalol and atenolol drugs with ?-cyclodextrin (?-CD) were investigated by UV-visible, fluorometry, time resolved fluorescence, FT-IR, 1H NMR, SEM and PM3 methods. The above drugs gave a single emission maximum in water where as dual emission in ?-CD. In ?-CD solutions the shorter wavelength fluorescence intensity was regularly decreased and longer wavelength fluorescence intensity increased. Addition of ?-CD to aqueous solutions of drugs resulted into excimer emission. The excimer emission is concluded to be due to a 1:2 inclusion complex between ?-CD and drug. Nanosecond time-resolved studies indicated that all drugs exhibited biexponential decay in solvents and triexponential decay in CD. Investigations of thermodynamic and electronic properties confirmed the stability of the inclusion complex.

Antony Muthu Prabhu, A.; Subramanian, V. K.; Rajendiran, N.



Inhibitory effect of atenolol on urinary excretion of metformin via down-regulating multidrug and toxin extrusion protein 1 (rMate1) expression in the kidney of rats.  


Renal tubular secretion is an important pathway for the elimination of many clinically used drugs. Metformin, a commonly prescribed first-line antidiabetic drug, is secreted primarily by the renal tubule. Many patients with type 2 diabetes mellitus (T2DM) receiving metformin may together be given selective ?1 blockers (e.g., atenolol). Therefore, it is of great use to evaluate the effect of atenolol on metformin urinary excretion for exploring drug interactions and predicting the adverse effect of drugs. The aim of this study was to investigate the effect of atenolol on the pharmacokinetic of metformin and plasma lactate (LCA) level in rats, for high LCA is a serious adverse reaction ofmetformin after long-term metformin treatment. In this study, rats were treated with metformin alone or in combination with atenolol. Plasma, urine and tissue concentration of metformin was determined by HPLC method, while Western blotting and immunohistochemical analysis were used to evaluate the renal expression of rat organic cation transporter 2 (rOct2) and multidrug and toxin extrusion protein 1 (rMate1). The results showed that, after 7days drug treatment, the AUC0?t of metformin in atenolol and metformin co-administration group was significantly increased by 19.5% compared to that in metformin group, while the 24h cumulative urinary excretion of metformin was significantly decreased by 57.3%. In addition, atenolol treatment significantly decreased the renal expression of rMate1, but had no effect on rOct2 expression, renal blood perfusion and glomerular filtration. Moreover, plasma LCA level in atenolol and metformin co-administration group was significantly increased by 83.3% compared to that in metformin group after 60days drug treatment. These results indicated that atenolol can inhibit urinary excretion of metformin via decreasing renal rMate1 expression, and long-term atenolol and metformin co-administration may induce potential lactic acidosis. Our results, for the first time, provided an important experimental evidence that rMate1 is the target of transporter-mediated drug interactions concerning metformin and atenolol. PMID:25486332

Ma, Yan-Rong; Huang, Jing; Shao, Yun-Yun; Ma, Kang; Zhang, Guo-Qiang; Zhou, Yan; Zhi, Rao; Qin, Hong-Yan; Wu, Xin-An



Sensitivity to insulin during treatment with atenolol and metoprolol: a randomised, double blind study of effects on carbohydrate and lipoprotein metabolism in hypertensive patients  

Microsoft Academic Search

OBJECTIVE--To compare the effects of metoprolol and atenolol on carbohydrate and lipid metabolism and on insulin response to an intravenous glucose load. DESIGN--Randomised, double blind, double dummy, controlled crossover trial. SETTING--University Hospital, Uppsala, Sweden. PATIENTS--60 Patients with primary hypertension (diastolic blood pressure when resting supine 95-119 mm Hg on at least two occasions during four to six weeks of treatment

T. Pollare; H. Lithell; I. Selinus; C. Berne



Mechanism(s) of selective systolic blood pressure reduction after a low-dose combination of perindopril\\/Indapamide in hypertensive subjects: comparison with atenolol  

Microsoft Academic Search

ObjectivesThe goal of this study was to determine if a low-dose combination of the angiotensin-converting enzyme inhibitor perindopril (Per) and the diuretic indapamide (Ind) reduces central (thoracic aorta, carotid artery) as well as brachial systolic blood pressure (SBP) more than the beta-blocker atenolol and to determine the hemodynamic factors influencing independently brachial and central SBP: pulse wave velocity (PWV) and

Gérard M London; Roland G Asmar; Michaël F O'Rourke; Michel E Safar



Interindividual variation of beta-adrenoceptor blocking drugs, plasma concentration and effect: Influence of genetic status on behaviour of atenolol, bopindolol and metoprolol  

Microsoft Academic Search

Ten healthy subjects whose genetic oxidative phenotype had been determined (6 extensive and 4 poor metabolizers of the debrisoquine-sparteine type of polymorphism) received single oral doses of 3 beta-blockers: atenolol, bopindolol and metoprolol. The plasma concentrations and the extent of the decrease in exercise-induced tachycardia were determined. The oxidative polymorphism was only significant for substances that had a high hepatic

P. Dayer; T. Leemann; A. Marmy; J. Rosenthaler



Comparison of controlled-onset, extended-release verapamil with amlodipine and amlodipine plus atenolol on exercise performance and ambulatory ischemia in patients with chronic stable angina pectoris  

Microsoft Academic Search

This multicenter, randomized, double-blind, parallel group, placebo lead-in, placebo-controlled study compared the antianginal and anti-ischemic effects of once-daily bedtime dosing of controlled-onset extended-release (COER-24) verapamil to a once-daily morning dosing of amlodipine ± atenolol in patients with chronic stable angina. A total of 551 patients with exercise-induced myocardial ischemia and evidence of coronary artery disease were randomized to a 4-week,

William H Frishman; Stephen Glasser; Peter Stone; Prakash C Deedwania; Mary Johnson; T. Daniel Fakouhi




Microsoft Academic Search

A rapid, simple, sensitive, and selective chromatographic method has been developed for the simultaneous estimation of atorvastatin calcium, losartan potassium, atenolol, and aspirin in marketed formulation. The separation was carried out on a KYA TECH HiQ Sil C18HS (250 × 4.6 mm i.d., 5 µm particle size) column using a mobile phase of acetonitrile: 0.02 M potassium dihydrogen phosphate buffer (pH 3.4) (70:30% v\\/v). The

Neela M. Bhatia; Sachin B. Gurav; Swapnil D. Jadhav; Manish S. Bhatia



Randomised, double blind, multicentre comparison of hydrochlorothiazide, atenolol, nitrendipine, and enalapril in antihypertensive treatment: results of the HANE study. HANE Trial Research Group.  

PubMed Central

OBJECTIVE: To compare the effectiveness and tolerability of hydrochlorothiazide, atenolol, nitrendipine, and enalapril in patients with mild to moderate hypertension. DESIGN: Randomised multicentre trial over 48 weeks with double blind comparison of treatments. SETTING: 48 centres in four countries. PATIENTS: 868 patients with essential hypertension (diastolic blood pressure 95-120 mm Hg) INTERVENTIONS: Initial treatment (step 1) consisted of 12.5 mg hydrochlorothiazide (n = 215), 25 mg atenolol (n = 215), 10 mg nitrendipine (n = 218), or 5 mg enalapril (n = 220) once daily. If diastolic blood pressure was not reduced to < 90 mm Hg within four weeks, doses were increased to 25 mg, 50 mg, 20 mg, 10 mg, respectively, once daily (step 2) and after two more weeks to twice daily (step 3). The eight week titration phase was followed by an additional 40 weeks for patients who had reached the target diastolic pressure. MAIN OUTCOME MEASURES: Blood pressure by means of an automatic device with repeated measurements. RESULTS: After eight weeks the response rate for atenolol (63.7%) was significantly higher than for enalapril (50.0%), hydrochlorothiazide (44.7%), or nitrendipine (44.5%). After one year atenolol was still more effective (48.0%) than hydrochlorothiazide (35.4%) and nitrendipine (32.9%), but not significantly better than enalapril (42.7%). The treatment related dropout rate was higher (P < 0.001) in the nitrendipine group (n = 28). CONCLUSIONS: There is no evidence of superiority for antihypertensive effectiveness or tolerability of the "new" classes of antihypertensives (calcium channel blockers and angiotensin converting enzyme inhibitors). As these drugs are now widely used as treatment of first choice, our results further emphasise the need for studies confirming that they also reduce morbidity and mortality, as has been shown for diuretics and beta blockers. PMID:9251545

Philipp, T.; Anlauf, M.; Distler, A.; Holzgreve, H.; Michaelis, J.; Wellek, S.



Sensitive Spectrophotometric Determination of Atenolol in Pharmaceutical Formulations Using Bromate-Bromide Mixture as an Eco-Friendly Brominating Agent  

PubMed Central

Three simple and sensitive spectrophotometric methods are proposed for the determination of atenolol (ATN) in bulk drug and tablets. The methods are based on the bromination of ATN by the bromine generated in situ by the action of the acid on the bromate–bromide mixture followed by the determination of unreacted bromine by reacting with a fixed amount of either meta-cresol purple (MCP) and measuring the absorbance at 540?nm (method A) and 445?nm (method B) or erioglaucine (EGC) and measuring the absorbance at 630?nm (method C). Beer's law is valid within the concentration ranges of 1.0–20.0, 2.0–40.0 and 1.0–8.0??g/mL for method A, method B and method C, respectively. The calculated molar absorptivities were found to be 1.20×104, 4.51×103 and 3.46 × 104??L/mol · cm for method A, method B and method C, respectively. Sandell's sensitivity values, correlation coefficients, limits of detection and quantification are also reported. Recovery results were statistically compared with those of a reference method by applying Student's t- and F-test. The novelty of the present study is the measurement of two different colors using MCP, that is, red-pink color of MCP in acid medium at 540?nm and yellowish-orange color of brominated MCP at 445?nm. PMID:22567567

Prashanth, Kudige N.; Basavaiah, Kanakapura



Sensitive spectrophotometric determination of atenolol in pharmaceutical formulations using bromate-bromide mixture as an eco-friendly brominating agent.  


Three simple and sensitive spectrophotometric methods are proposed for the determination of atenolol (ATN) in bulk drug and tablets. The methods are based on the bromination of ATN by the bromine generated in situ by the action of the acid on the bromate-bromide mixture followed by the determination of unreacted bromine by reacting with a fixed amount of either meta-cresol purple (MCP) and measuring the absorbance at 540?nm (method A) and 445?nm (method B) or erioglaucine (EGC) and measuring the absorbance at 630?nm (method C). Beer's law is valid within the concentration ranges of 1.0-20.0, 2.0-40.0 and 1.0-8.0??g/mL for method A, method B and method C, respectively. The calculated molar absorptivities were found to be 1.20×10(4), 4.51×10(3) and 3.46 × 10(4)??L/mol · cm for method A, method B and method C, respectively. Sandell's sensitivity values, correlation coefficients, limits of detection and quantification are also reported. Recovery results were statistically compared with those of a reference method by applying Student's t- and F-test. The novelty of the present study is the measurement of two different colors using MCP, that is, red-pink color of MCP in acid medium at 540?nm and yellowish-orange color of brominated MCP at 445?nm. PMID:22567567

Prashanth, Kudige N; Basavaiah, Kanakapura



Long-term treatment of clonidine, atenolol, amlodipine and dihydrochlorothiazide, but not enalapril, impairs the sexual function in male spontaneously hypertensive rats.  


This study was designed to investigate the impact of representative antihypertensive drugs of 5 classes on the sexual function in male spontaneously hypertensive rats (SHR) at doses that achieved similar blood pressure (BP) reduction. The experiment was performed in 6 groups of male SHR. The dose are 20 ?g/kg/day for clonidine, 3 mg/kg/day for enalapril, 20 mg/kg/day for atenolol, 2 mg/kg/day for amlodipine, and 10 mg/kg/day for dihydrochlorothiazide. SHR were treated for 3 months, and then the penile erection and sexual behavior were detected. After BP recording, SHR were killed to evaluate the organ-damage, weight of accessory sex organs and levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone in serum. Five drugs had the similar efficacy on BP reduction. All drugs except of enalapril, significantly prolonged the mount latency, and decreased the mount frequency (P<0.05). Clonidine also reduced the conception rate (45% vs. 80% in control group, P<0.05). Amlodipine and dihydrochlorothiazide significantly increased the testosterone level (0.79±0.30, 0.80±0.34 vs. 0.49±0.20 in control group, unit: ng/dl, P<0.05). Enalapril, atenolol and amlodipine also significantly decreased the BP variability (systolic, 8.2±2.5, 7.6±1.8, 8.9±2.0 vs. 12.2±3.8 in control group, unit: mm Hg). All these drugs significantly decreased the organ-damage (P<0.05). In conclusion, long-term treatment with 5 common antihypertensive drugs possessed obvious organ protection in SHR. Clonidine, atenolol, amlodipine and dihydrochlorothiazide, but not enalapril, impair sexual function. PMID:25615941

Lin, Li-Li; Wang, Dong; Wang, Wei; Cheng, Yan-Qiong; Su, Ding-Feng; Liu, Ai-Jun



Long-Term Treatment of Clonidine, Atenolol, Amlodipine and Dihydrochlorothiazide, but Not Enalapril, Impairs the Sexual Function in Male Spontaneously Hypertensive Rats  

PubMed Central

This study was designed to investigate the impact of representative antihypertensive drugs of 5 classes on the sexual function in male spontaneously hypertensive rats (SHR) at doses that achieved similar blood pressure (BP) reduction. The experiment was performed in 6 groups of male SHR. The dose are 20 ?g/kg/day for clonidine, 3 mg/kg/day for enalapril, 20 mg/kg/day for atenolol, 2 mg/kg/day for amlodipine, and 10 mg/kg/day for dihydrochlorothiazide. SHR were treated for 3 months, and then the penile erection and sexual behavior were detected. After BP recording, SHR were killed to evaluate the organ-damage, weight of accessory sex organs and levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone in serum. Five drugs had the similar efficacy on BP reduction. All drugs except of enalapril, significantly prolonged the mount latency, and decreased the mount frequency (P<0.05). Clonidine also reduced the conception rate (45% vs. 80% in control group, P<0.05). Amlodipine and dihydrochlorothiazide significantly increased the testosterone level (0.79±0.30, 0.80±0.34 vs. 0.49±0.20 in control group, unit: ng/dl, P<0.05). Enalapril, atenolol and amlodipine also significantly decreased the BP variability (systolic, 8.2±2.5, 7.6±1.8, 8.9±2.0 vs. 12.2±3.8 in control group, unit: mm Hg). All these drugs significantly decreased the organ-damage (P<0.05). In conclusion, long-term treatment with 5 common antihypertensive drugs possessed obvious organ protection in SHR. Clonidine, atenolol, amlodipine and dihydrochlorothiazide, but not enalapril, impair sexual function. PMID:25615941

Lin, Li-Li; Wang, Dong; Wang, Wei; Cheng, Yan-Qiong; Su, Ding-Feng; Liu, Ai-Jun



Simple, sensitive and selective spectrophotometric methods for the determination of atenolol in pharmaceuticals through charge transfer complex formation reaction.  


Three rapid, selective and sensitive spectrophotometric methods have been proposed for the quantitative determination of atenolol (ATN) in pure form as well as in its pharmaceutical formulation. The methods are based on charge transfer complexation reaction of ATN as n-electron donor with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), 2,4-dinitrophenol (DNP) and 2,4,6-trinitrophenol (picric acid; PA) as pi-acceptors to give highly colored radical anion species. The colored products were quantified spectrophotometrically at 590 nm with DDQ (method A) and at 420 nm with both DNP (method B) and PA (method C). Under the optimized experimental conditions, Beer's law is obeyed over the concentration ranges of 3-48, 2-24 and 1.5-18 ?g/mL ATN for method A, method B and method C, respectively. The molar absorptivity, Sandell sensitivity, limits of detection and quantification are also reported. The effects of reaction medium, reaction time and reagent concentration on the sensitivity and stability of the complexes formed have been examined. The proposed methods were successfully applied to the determination of ATN in pure form and commercial tablets with good accuracy and precision. Statistical comparison of the results was performed using Student's t-test and F-ratio at 95% confidence level and the results showed no significant difference between the reference and proposed methods with regard to accuracy and precision. Further, the accuracy and reliability of the methods were confirmed by recovery studies via standard addition technique. PMID:22568035

Prashanth, Kudige Nagaraju; Basavaiah, Kanakapura



Hamartoma fibrolipomatoso e macrodistrofia lipomatosa: análise dos achados clínicos e de imagem em quatro casos, com revisão da literatura  

Microsoft Academic Search

O hamartoma fibrolipomatoso neural e a macrodistrofia lipomatosa são doenças raras, com achados de imagem característicos. Radiografias simples, estudos de ressonância magnética e prontuários médicos de quatro pacientes foram revisados. Em um paciente, foi realizada cirurgia com confirmação histopatológica. Em três pacientes, os achados clínicos e de imagem foram considerados suficientes para o diagnóstico. Descreve- mos dois casos de macrodistrofia

Rafael Darahem de Souza Coelho; Marcelo Novelino Simão; Clóvis Simão Trad



Sensibilidade antimicrobiana de bactérias aeróbicas isoladas de úlceras leishmanióticas, em Corte de Pedra, BA  

Microsoft Academic Search

RESUMO Um estudo prospectivo, sobre a sensibilidade antimicrobiana da flora bacteriana em úlceras cutâneas leishmanióticas, foi realizado em pacientes portadores de leishmaniose tegumentar, em Corte de Pedra, Bahia. Foram estudados 84 pacientes, principalmente adolescentes e adultos dedicados à lavoura, apresentando lesão cutânea única. Staphylococcus aureus predominou (83%) nas culturas, sendo sensível à maioria dos antibióticos testados. Flora bacteriana mista esteve

Luis Angel Vera; Jefferson Lessa Soares de Macedo; Isolina Allen Ciuffo; Conceição Guerra Santos; João Barberino Santos



Development of a MSFIA sample treatment system as front end of GC-MS for atenolol and propranolol determination in human plasma.  


An on-line solid-phase extraction (SPE) method coupled to gas chromatography-mass spectrometry (GC-MS) has been developed for the determination of atenolol (ATN) and propranolol (PRO) in human plasma. The hyphenation of SPE with multisyringe flow injection analysis (MSFIA) allows the simultaneous GC-MS determination of ATN and PRO with high selectivity and sensitivity. On-line preconcentration and derivatisation of the analytes were carried out by means of using restricted access materials (RAM) and microwave (MW) assisted derivatisation reactions with N-methyl-N-(trimethylsilyl) trifluoroacetamide (MSTFA)+1% trimethylchlorosilane (TMCS). Multivariate optimization was applied to optimize experimental conditions. The whole procedure comprising sample pretreatment and analyte determination took about 15 min. However, the overlap of the automatic sample treatment with the GC separation increased the frequency to 7 samples h(-1). The validated method was successfully applied to direct ATN and PRO determination in human plasma. PMID:25476273

Brunetto, María del Rosario; Clavijo, Sabrina; Delgado, Yelitza; Orozco, Wendy; Gallignani, Máximo; Ayala, Carlos; Cerdà, Víctor



ATUAÇÃO DO FISIOTERAPEUT A NO ATENDIMENTO DOMICILIAR DE PACIENTES NEUROLÓGICOS: A EFETIVIDADE SOB A VISÃO DO CUIDADOR The physiotherapist's performance in the domicile attendance of neurological patients: the effectiveness under the caretaker's point of view  

Microsoft Academic Search

RESUMO Alguns pacientes neurológicos apresentam alterações e distúrbios da cinesia funcional que os impedem de exercer sua autonomia física, repercutindo sobre sua estrutura psicológica e socioeconômica. Em decorrência desses distúrbios, os pacientes possuem graus variáveis de incapacidade que determinam níveis de dependência ao cuidador. Este trabalho teve como objetivo investigar a efetividade da Fisioterapia no quadro clínico do paciente neurológico,

Diolina Nogueira Leite Felício; Ana Luiza; Veras Franco; Maria Edvani Araújo Torquato; Ana Paula de Vasconcellos


Polypill for the treatment of cardiovascular diseases part 2. LC-MS/TOF characterization of interaction/degradation products of atenolol/lisinopril and aspirin, and mechanisms of formation thereof.  


A polypill for cardiovascular diseases (CVD) is under development. It is proposed to contain a combination of antithrombotic agent (aspirin), low-dose blood pressure lowering agents, i.e., angiotensin-converting enzyme inhibitor (lisinopril), one among a beta-blocker (atenolol) or diuretic (hydrochlorothiazide), and a statin (simvastatin/atorvastatin/pravatsatin, etc.). Due to the presence of multiple drugs in the same formulation, there is a strong likelihood of interaction among the drugs and/or their products. In a previous study, we observed formation of a number of interaction/degradation products from atenolol and lisinopril in the presence of aspirin. Accordingly, the purpose of this study was to characterize the resolved products using high resolution mass spectrometric and fragmentation analyses using a LC-MS/TOF system. Initially, studies were carried out on the drugs (atenolol, lisinopril and aspirin) to establish their complete fragmentation pattern. These studies were then extended to degraded samples to postulate the structures of interaction/degradation products. The characterized structures were justified through mechanistic explanations. PMID:18635333

Kumar, Vijay; Malik, Satish; Singh, Saranjit



Identificação fenotípica e molecular, perfil de suscetibilidade aos antifúngicos e detecção de glucuronoxilomanana em isolados clínicos de Trichosporon.  

E-print Network

??Infecções invasivas por Trichosporon spp. ocorrem com maior frequência em pacientes neutropênicos, principalmente portadores de doenças hematológicas malignas, e estão associadas a elevados índices de… (more)

Dulce Sachiko Yamamoto de Figueiredo



The ?-blocker atenolol lowers the longevity-related degree of fatty acid unsaturation, decreases protein oxidative damage, and increases extracellular signal-regulated kinase signaling in the heart of C57BL/6 mice.  


The interruption of the ?-adrenergic receptor signaling at the level of adenylyl cyclase (AC) by specifically knocking out (KO) the AC5 gene activates the RAF/MEK/ extracellular signal-regulated kinase (ERK) signaling pathway, delays bone and heart aging, and increases mean and maximum longevity in mice. However, the mechanisms involved in life extension in this animal model with increased longevity have not been clarified, although a decrease in oxidative stress has been proposed as mediator. Two traits link longevity and oxidative stress. Long-lived mammals and birds have a low rate of mitochondrial reactive oxygen species (mitROS) generation and a low degree of membrane fatty acid unsaturation, but these key factors have not been studied in AC5 KO mice. In the present investigation, male C57BL/6 mice were treated with the ?-blocker atenolol in drinking water, and oxidative stress-related parameters were measured in the heart. Atenolol treatment did not change the rate of mitROS production and oxidative damage to mitDNA (8-oxo-7,8-dihydro-2'-deoxyguanosine [8-oxodG]), but strongly decreased the degree of fatty acid unsaturation and the peroxidizability index, mainly due to decreases in 22:6n-3 and 20:4n-6 and to increases in 18:1n-9, 16:1n-7 and 16:0 in the atenolol group. Protein oxidation and lipoxidation were lower in the atenolol group than in the controls. The mitochondrial complex I and IV content and the amount of p-ERK1/2 signaling proteins were significantly higher in the atenolol-treated than in the control animals. These results support the idea that the increased longevity of the AC5 KO mice can be due in part to an ERK signaling-mediated stress-resistance due to a decrease in fatty acid unsaturation, leading to lower lipid peroxidation and decreased lipoxidation-derived damage to cellular proteins. PMID:20818929

Sanchez-Roman, Ines; Gomez, Jose; Naudi, Alba; Ayala, Victoria; Portero-Otín, Manuel; Lopez-Torres, Monica; Pamplona, Reinald; Barja, Gustavo



Characteristics of children and young adults with Marfan syndrome and aortic root dilation in a randomized trial comparing atenolol and losartan therapy  

PubMed Central

Background The Pediatric Heart Network designed a clinical trial to compare aortic root growth and other short-term cardiovascular outcomes in children and young adults with Marfan syndrome randomized to receive atenolol or losartan. We report here the characteristics of the screened population and enrolled subjects. Methods and results Between 2007 and 2011, 21 clinical sites randomized 608 subjects, aged 6 months to 25 years who met the original Ghent criteria and had a body surface area–adjusted aortic root diameter z-score >3.0. The mean age at study entry was 11.2 years, 60% were male, and 25% were older teenagers and young adults. The median aortic root diameter z-score was 4.0. Aortic root diameter z-score did not vary with age. Mitral valve prolapse and mitral regurgitation were more common in females. Among those with a positive family history, 56% had a family member with aortic surgery, and 32% had a family member with a history of aortic dissection. Conclusions Baseline demographic, clinical, and anthropometric characteristics of the randomized cohort are representative of patients in this population with moderate to severe aortic root dilation. The high percentage of young subjects with relatives who have had aortic dissection or surgery illustrates the need for more definitive therapy; we expect that the results of the study and the wealth of systematic data collected will make an important contribution to the management of individuals with Marfan syndrome. PMID:23622922

Lacro, Ronald V.; Guey, Lin T.; Dietz, Harry C.; Pearson, Gail D.; Yetman, Anji T.; Gelb, Bruce D.; Loeys, Bart L.; Benson, D. Woodrow; Bradley, Timothy J.; De Backer, Julie; Forbus, Geoffrey A.; Klein, Gloria L.; Lai, Wyman W.; Levine, Jami C.; Lewin, Mark B.; Markham, Larry W.; Paridon, Stephen M.; Pierpont, Mary Ella; Radojewski, Elizabeth; Selamet Tierney, Elif Seda; Sharkey, Angela M.; Wechsler, Stephanie Burns; Mahony, Lynn



Validated stability-indicating methods for the simultaneous determination of amiloride hydrochloride, atenolol, and chlorthalidone using HPTLC and HPLC with photodiode array detector.  


Two stability-indicating chromatographic methods are described for simultaneous determination of amiloride hydrochloride (AMI), atenolol (ATE), and chlorthalidone (CHL) in combined dosage forms. The first method was based on HPTLC separation of the three drugs followed by densitometric measurements of their bands at 274 nm. The separation was carried out on Merck HPTLC silica gel 60F254 aluminum sheets using chloroform-methanol-ammonia 27%, w/w (9 + 2 + 0.3, v/v/v) mobile phase. Analysis data was used for the linear regression graph in the range of 0.1-0.5, 0.8-5.0, and 0.3-1.5 microg/band for AMI, ATE, and CHL, respectively. The second method was based on an RP-HPLC separation of the cited drugs performed on an RP stainless steel C18 analytical column (250 x 4.6 mm id) with a gradient elution system of methanol and 0.05 M aqueous phosphate buffer adjusted to pH 4 as the mobile phase, at the flow rate of 1.0 mL/min. Quantitation was achieved with photodiode array detection at 275 nm for AMI and 225 nm for ATE and CHL. The calibration graphs for each drug were rectilinear in the range of 2-50, 25-150, and 2-100 microg/mL for AMI, ATE, and CHL, respectively. The proposed chromatographic methods were successfully applied for determination of the investigated drugs in pharmaceutical preparations. Both methods were validated in compliance with International Conference on Harmonization guidelines in terms of linearity, accuracy, precision, robustness, LOD, and LOQ. PMID:23767356

Youssef, Rasha M; Maher, Hadir M; El-Kimary, Eman I; Hassan, Ekram M; Barary, Magda H



Transtorno Obsessivo-Compulsivo e Tiques em Pacientes com Epilepsia  

Microsoft Academic Search

Obsessive-compulsive disorder and tic disorders in patients with epilepsy Objective: To describe and discuss evidence-based articles on the association of epilepsy, obsessive-compulsive disorder (OCD) and tic disorders. Method: A review of the most relevant papers on the association of OCD, tics and epilepsy. Results: Psychiatric disorders are common in patients with epilepsy. Nevertheless, the association between obsessive-compulsive symptoms, tics and

Marielza Fernandez Veiga; Maria Conceição do Rosario-Campos; Lucas de Castro Quarantini; Marcos Tomanik Mercadante



Alterações comportamentais graves em paciente com doença de Fahr  

Microsoft Academic Search

Severe behavioral changes in a patient with Fahr's disease ABSTRACT - We report on a case of a 40 year-old man with Fahr's disease, defined by idiopathic bilateral basal ganglia calcification, who developed depressive disord e r, motor and phonic tics, stereotyped behaviors such as punding and personality changes with significant social and familiar implications. We discuss about the psychopathology

Arthur Kümmer; Maila de Castro; Paulo Caramelli; Francisco Cardoso; Antônio Lúcio Teixeira



Acompanhamento nutricional individualizado de um paciente pediátrico: relato de caso Individualized nutritional care for a pediatric patient: case report Cuidado alimenticio individualizado para un paciente pediátrico: relato de caso  

Microsoft Academic Search

ReSumo: Este acompanhamento nutricional foi realizado com um paciente pediátrico com Insuficiência Renal Crônica, Síndrome Hemolítica Urêmica e Hipertensão Arterial, selecionado pela necessidade de se favorecer seu quadro clínico, devido às altas taxas de morbi-mortalidade em crianças renais. O objetivo deste trabalho é favorecer crescimento, desenvolvimento e sobrevida com qualidade. Esta pesquisa experimental, do tipo caso clínico, foi realizada com

Thaís Morgado Lamonica; Vera Sílvia Frangella; Elen Pessina


Los Derechos de los Pacientes del Centro Clnico  

E-print Network

Los Derechos de los Pacientes del Centro Clínico Los Derechos de los Pacientes del Centro Clínico medir las respuestas de los pacientes al tratamiento. Existen procesos que protegen los derechos de paciente que se observen los derechos fundamentales de la dignidad humana. Esta Declaración de Derechos



PubMed Central

Existen prejuicios en relación con la vejez, incluso entre los profesionales que se dedican a la gerontología. Uno común y peligroso es considerar que los viejos son todos enfermos o discapacitados. La relación médico-paciente es la piedra angular de la práctica y ética médicas. Para alcanzar el respeto por los adultos mayores es necesaria una medicina prudente, basada en una práctica en la cual la reflexión ética y clínica pueda contribuir. Esto último es posible si se hacen valer los derechos del adulto mayor, en particular como paciente para la toma de decisiones. PMID:20379380

Barrantes-Monge, Melba; Rodríguez, Eduardo; Lama, Alexis



Seguridad del paciente en los estudios clínicos

Información para pacientes, sus familiares y amigos, y el público en general, sobre cómo se protegen los derechos y la seguridad de las personas que participan en estudios clínicos. Conozca sobre el consentimiento formal, los consejos institucionales de revisión (IRB) y cómo se realiza la vigilancia continua de los estudios.


Familiares a cargo de pacientes de cáncer (PDQ®)

Sumario informativo revisado por expertos acerca de los desafíos que enfrentan los familiares a cargo de los pacientes con cáncer. Este resumen se centra en las funciones típicas y las inquietudes de las personas a cargo del paciente y en las intervenciones útiles para esas personas.


Sintomas Depressivos e Qualidade de Vida em Indivíduos com Epilepsia por Esclerose Mesial Temporal  

Microsoft Academic Search

RESUMO Introdução: Dificuldades no trabalho, em relacionamentos interpessoais, familiares e sociais, a percepção do estigma, da discriminação dentre outros têm sido associados aos estados depressivos interictais, influen- ciando negativamente a qualidade de vida (QV) das pessoas com epilepsia. A depressão tem alta prevalência (20 a 55%) nas epilepsias, sendo vista como o fator mais importante no julgamento do paciente sobre

Neide Barreira Alonso; Tatiana Indelicato da Silva; Ana Carolina Westphal; Auro Mauro Azevedo


Efeitos do método Watsu em paciente asmático moderado - relato de caso  

Microsoft Academic Search

SUMMARY The present study has as objective to evaluate the effect of the Watsu Method in the thoracic mobility, ventilation, state of anxiety, depression and quality of life of moderate asthmatic pa- tients. An individual was submitted to 10 sessions of the Watsu Method during 5 weeks. The pre and post-treatment evaluation consisted of questionnaires to quantify the signals and

Ana Angélica; Ribeiro de Lima; Kátia de Souza Pereira


Autoanticorpos órgão-específicos e sistêmicos em pacientes com lúpus eritematoso sistêmico juvenil e dermatomiosite juvenil.  

E-print Network

??Objetivo: Ao nosso conhecimento, não há estudos na literatura avaliando simultaneamente um grande número de autoanticorpos órgãoespecíficos, bem como a prevalência de doenças autoimunes órgãoespecíficas… (more)

Nádia Emi Aikawa



Avaliação da função gonadal em pacientes do sexo masculino com dermatomiosite e polimiosite.  

E-print Network

??Objective: To perform a global gonad evaluation in male idiopathic inflammatory myopathies (IIM) patients. Methods: Twentyfive consecutive IIM were compared to 25 age-matched healthy subjects.… (more)

Ana Julia Pantoja de Moraes



Avaliação de Falhas em Implantes Metálicos CoxoFemoral e Joelho Retirados de Pacientes  

Microsoft Academic Search

There are over 150,000 such hip replacement operations performed in the Brazil each year. Many people suffer from knee or hip joint pain, caused by the wear and tear produced by walking millions of steps a year. After many years this can lead to osteoarthritis which is the commonest form of degenerative disease of the hip. Accidents may also lead

K. B. Fonseca; H. H. Pereira; S. N. Silva



Visión Estereo para Posicionamiento de Pacientes en Radioterapia  

Microsoft Academic Search

Resumen— Durante la radioterapia se administran dosis tumoricidas con el fin de eliminar las células cancerosas. Una vez que se ha determinado la\\/las regiones a irradiar, se debe tener especial cuidado en el posicionamiento del paciente en el acelerador lineal y su posterior re-posicionamiento de modo tal que la zona bajo tratamiento sea siempre la misma, minimizando el daño al

Arnulfo Ortiz Torres; Andrés Valdez; Guillermo Alvarez


EM International. Volume 1  

SciTech Connect

It is the intent of EM International to describe the Office of Environmental Restoration and Waste Management`s (EM`s) various roles and responsibilities within the international community. Cooperative agreements and programs, descriptions of projects and technologies, and synopses of visits to international sites are all highlighted in this semiannual journal. Focus on EM programs in this issue is on international collaboration in vitrification projects. Technology highlights covers: in situ sealing for contaminated sites; and remote sensors for toxic pollutants. Section on profiles of countries includes: Arctic contamination by the former Soviet Union, and EM activities with Germany--cooperative arrangements.

Not Available



Quimioterapia de alta dosis prolonga en forma significativa la supervivencia en pacientes con leucemia mieloide aguda

Los resultados preliminares de un estudio clínico grande con asignación al azar de pacientes de 16 a 60 años de edad con leucemia mieloide aguda (LMA), un cáncer de la sangre y de la médula ósea, que no había sido tratada anteriormente, muestran que los pacientes que recibieron una alta dosis de daunorrubicina, un fármaco de quimioterapia disponible comercialmente, durante la terapia inicial vivieron más que los pacientes que recibieron una dosis normal del mismo fármaco.


Environmental Media Services (EMS)  

NSDL National Science Digital Library

Environmental Media Services (EMS) is a nonprofit communications clearinghouse committed to the expansion of media coverage on critical environmental and public health issues. True to their mission, EMS staff "build relationships with top scientists, physicians, and other experts to bring journalists the latest and most credible information." EMS's modest homepage is free of clutter but full of content. While several sections are under construction and updates (currently) appear irregular, a series of available articles provides useful summaries of important environmental news issues over the past six months. Current articles include "The impacts of global warming on the oceans" and "Cool companies," among others.



E-print Network

OPTIMIZAC¸ ~ AO EM REDES UMA VIS ~ AO GLOBAL Deolinda Dias Rasteiro, Jose Luis Santos, Marta Braz; Optimiza¸c~ao em Redes ­ Uma Vis~ao Global N = fv 1 ; : : : ; v n g j f1; : : : ; ng ­ conjunto de n'os (v est~ao associados parâ??ametros Exemplo: `j 'i 1 `j 'i 2 `j 'i 3 `j 'i 4 \\Gamma \\Gamma \\Gamma \\Gamma

Pascoal, Marta Margarida Braz


Familiares a cargo de pacientes de cáncer: funciones y desafíos (PDQ®)

Sumario informativo revisado por expertos acerca de los desafíos que enfrentan los familiares a cargo de los pacientes con cáncer. Este resumen se centra en las funciones típicas y las inquietudes de las personas a cargo del paciente y en las intervenciones útiles para esas personas.


Impacto de las redes sociales de pacientes en la práctica asistencial  

Microsoft Academic Search

Las redes sociales de pacientes son espacios virtuales donde pacientes con condiciones similares se ponen en contacto y comparten tratamientos y problemas de salud. Estas redes ofrecen a las personas con problemas específicos de salud la oportunidad de compartir experiencias, buscar, recibir y proveer información, consejos e incluso apoyo emocional online. Pero, ¿cuál es el impacto de estas redes en

Elena Torrente; Joan Escarrabill; Tino Martí



Autorizacin para divulgar informacin mdica Nombre del paciente: ________________________________ Fecha de nacimiento: ______________  

E-print Network

) HIPAA Compliance / Columbia University Medical Center 630 West 168th Street, Box 159 New York, NY 10032, salud mental o psiquiatría pueden tener requisitos de conformidad adicionales que se deben cumplir antes paciente y entregue una copia al paciente. Health Insurance Portability and Accountability Act (HIPAA

Columbia University


*Bacharel em Turismo.  

E-print Network

algumas questões que ainda fazem parte das discussões sobre as necessárias reformas estatais originadas no período da transição democrática e que se estendem até os dias atuais. Discussões essas que incluem também as transformações ocorridas na sociedade e que colocam as propostas de reformas para além da estrutura do Estado. É neste período que se pronuncia o esgotamento do planejamento centralizado como instrumento de condução política, não só em função dos problemas intrínsecos à estrutura estatal, mas principalmente por este não conseguir planejar a sociedade em virtude da nova complexidade social. Aliás, complexidade é a noção predominante nesse contexto em que se abrem novas propostas de planejamento, definidas através da co-responsabilidade entre os representantes do Estado e da

Ana Valéria Endres; Palavras-chave Turismo; Estado Planejamento; Planejamento Turístico


EM Radiation Program  

NSDL National Science Digital Library

The EM Radiation program displays the electric field vectors (in the x-y plane) and magnetic field contours (for the field in the z direction) calculated from the Lienard-Wiechert potentials for a charged particle. The default scenario shows the resulting radiation from a charged particle in simple harmonic motion. Additional particle trajectories can be specified using the Display | Switch GUI menu item. EM Radiation is an Open Source Physics program written for the teaching of electromagnetism. It is distributed as a ready-to-run (compiled) Java archive. Double clicking the em_radiation.jar file will run the program if Java is installed. Other electromagnetism programs are also available. They can be found by searching ComPADRE for Open Source Physics, OSP, or electromagnetism.

Christian, Wolfgang



Gleevec disminuye la recidiva del cáncer en pacientes con tumor estromal gastrointestinal primario

Los resultados preliminares de un estudio clínico grande aleatorio y controlado con placebo, en pacientes con tumor estromal gastrointestinal (GIST) primario, un tipo de tumor que por lo general se encuentra en el estómago o en el intestino delgado, demostraron que los pacientes a los que se administró mesilato de imatinib (Gleevec®) luego de la extirpación total de su tumor tuvieron una probabilidad significativamente menor de padecer una recidiva del cáncer en comparación con aquellos a los que no se administró imatinib.


The EM Earthquake Precursor  

NASA Astrophysics Data System (ADS)

Many attempts have been made to determine a sound forecasting method regarding earthquakes and warn the public in turn. Presently, the animal kingdom leads the precursor list alluding to a transmission related source. By applying the animal-based model to an electromagnetic (EM) wave model, various hypotheses were formed, but the most interesting one required the use of a magnetometer with a differing design and geometry. To date, numerous, high-end magnetometers have been in use in close proximity to fault zones for potential earthquake forecasting; however, something is still amiss. The problem still resides with what exactly is forecastable and the investigating direction of EM. After the 1989 Loma Prieta Earthquake, American earthquake investigators predetermined magnetometer use and a minimum earthquake magnitude necessary for EM detection. This action was set in motion, due to the extensive damage incurred and public outrage concerning earthquake forecasting; however, the magnetometers employed, grounded or buried, are completely subject to static and electric fields and have yet to correlate to an identifiable precursor. Secondly, there is neither a networked array for finding any epicentral locations, nor have there been any attempts to find even one. This methodology needs dismissal, because it is overly complicated, subject to continuous change, and provides no response time. As for the minimum magnitude threshold, which was set at M5, this is simply higher than what modern technological advances have gained. Detection can now be achieved at approximately M1, which greatly improves forecasting chances. A propagating precursor has now been detected in both the field and laboratory. Field antenna testing conducted outside the NE Texas town of Timpson in February, 2013, detected three strong EM sources along with numerous weaker signals. The antenna had mobility, and observations were noted for recurrence, duration, and frequency response. Next, two directional techniques were employed, resulting in three mapped, potential epicenters. The remaining, weaker signals presented similar directionality results to more epicentral locations. In addition, the directional results of the Timpson field tests lead to the design and construction of a third prototype antenna. In a laboratory setting, experiments were created to fail igneous rock types within a custom-designed Faraday Cage. An antenna emplaced within the cage detected EM emissions, which were both reproducible and distinct, and the laboratory results paralleled field results. With a viable system and continuous monitoring, a fracture cycle could be established and observed in real-time. Sequentially, field data would be reviewed quickly for assessment; thus, leading to a much improved earthquake forecasting capability. The EM precursor determined by this method may surpass all prior precursor claims, and the general public will finally receive long overdue forecasting.

Jones, K. B., II; Saxton, P. T.



Growth and anthropometry in hemiplegic cerebral palsy patients Crescimento e antropometria em pacientes com paralisia cerebral hemiplégica  

Microsoft Academic Search

Objective: To analyze the linear growth, the head circum- ference and the anthropometric differences between involved and non-involved sides of 24 children with hemiplegic cer- ebral palsy, comparing them to standard values for age. Methods: This cross-sectional study enrolled 24 con- secutive children with cerebral palsy clinically classified as spastic hemiplegia. The anthropometric measures included: weight, lenght, head circumference, total

Marise Bueno Zonta; Fábio Agert; Sandra Regina; B. Muzzolon; Sérgio Antonio Antoniuk; Neiva Isabel; R. Magdalena; Isac Bruck


Caracterização molecular e perfil de sensibilidade de Candida tropicalis isoladas em corrente sanguínea e cateter de pacientes internados em hospitais de ensino.  

E-print Network

??Infecções causadas por Candida tropicalis (C. tropicalis) são associados à elevada morbi-mortalidade, e foram consideradas como importantes causas de infecção de corrente sanguínea no Hospital… (more)

Marcello Mihailenko Chaves Magri




EPA Science Inventory

This paper highlights the breadth and magnitude of carrying out an effective Environmental Management System (EMS) program at the U.S. EPA's research and development laboratories. Federal research laboratories have unique operating challenges compared to more centralized industr...


El NCI inicia un estudio para evaluar la utilidad de la secuenciación genética para mejorar los resultados en los pacientes

El Instituto Nacional del Cáncer (NCI) lanzará este mes un estudio clínico piloto denominado M-PACT con la finalidad de evaluar si el tratamiento asignado según mutaciones genéticas específicas puede brindar beneficios a pacientes con tumores sólidos metastásicos.


Angus Robichaud's Reel G Em D A Bm D7  

E-print Network

Angus Robichaud's Reel 4 4 D G A D D G A D 3 3 G Em D A Bm D7 3 3 G Em D A D Animas Reel Bernie Waugh 4 4 3 3 G D G Bm Em C Am C D G D G Bm Em C Am D G The Arkansas Traveler 4 2 D G A D Em A 3D G A D Em G A D D G D A Bm Em A D G D A Em G A D #12;Asher Rodney Miller 4 4 D Em F#m G A D Em G A D A D1 2

Doyle, Peter


Angus Robichaud's Reel G Em D A Bm D7  

E-print Network

Angus Robichaud's Reel 4 4 D G A D D G A D 3 3 G Em D A Bm D7 3 3 G Em D A D Animas Reel Bernie Waugh 4 4 3 3 G D G Bm Em C Am C D G D G Bm Em C Am D G The Arkansas Traveler 4 2 D G A D Em A 3 D G A D Em G A D D G D A Bm Em A D G D A Em G A D #12; Asher Rodney Miller 4 4 D Em F#m G A D Em G A D A D 1

Doyle, Peter


Correlation of the NBME Advanced Clinical Examination in EM and the National EM M4 exams  

PubMed Central

Introduction Since 2011 two online, validated exams for fourth-year emergency medicine (EM) students have been available (National EM M4 Exams). In 2013 the National Board of Medical Examiners offered the Advanced Clinical Examination in Emergency Medicine (EM-ACE). All of these exams are now in widespread use; however, there are no data on how they correlate. This study evaluated the correlation between the EM-ACE exam and the National EM M4 Exams. Methods From May 2013 to April 2014 the EM-ACE and one version of the EM M4 exam were administered sequentially to fourth-year EM students at five U.S. medical schools. Data collected included institution, gross and scaled scores and version of the EM M4 exam. We performed Pearson’s correlation and random effects linear regression. Results 303 students took the EM-ACE and versions 1 (V1) or 2 (V2) of the EM M4 exams (279 and 24, respectively). The mean percent correct for the exams were as follows: EM-ACE 74.8 (SD-8.83), V1 83.0 (SD-6.41), V2 78.5 (SD-7.70). Pearson’s correlation coefficient for the V1/EM-ACE was 0.51 (0.42 scaled) and for the V2/EM-ACE was 0.59 (0.41 scaled). The coefficient of determination for V1/EM-ACE was 0.72 and for V2/EM-ACE = 0.71 (0.86 and 0.49 for scaled scores). The R-squared values were 0.25 and 0.30 (0.18 and 0.13, scaled), respectively. There was significant cluster effect by institution. Conclusion There was moderate positive correlation of student scores on the EM-ACE exam and the National EM M4 Exams.

Hiller, Katherine; Miller, Emily S.; Lawson, Luan; Wald, David; Beeson, Michael; Heitz, Corey; Morrissey, Thomas; House, Joseph; Poznanski, Stacey



Análisis de componentes cognoscitivos y psiquiátricos en pacientes con demencia frontotemporal y alzheimer / Analysis of cognitive and psychiatric components in patients with frontotemporal dementia and Alzheimer.  

E-print Network

??Reyes Gavilán, Pablo Alexander (2010) Análisis de componentes cognoscitivos y psiquiátricos en pacientes con demencia frontotemporal y alzheimer / Analysis of cognitive and psychiatric components… (more)

Reyes Gavilán, Pablo Alexander



Lecture 12: EM Radiation (EMR)  

E-print Network

#12;James Clerk Maxwell You! 5 Finally, the pinnacle of EM... E · dA = qencl 0 B · dA = 0 E · dl = E = - dB dt{ Maxwell'sEquations F = q(E + v � B)Lorentz Force Law: Gauss's Law Gauss's Law for Mag. Faraday's Law Ampère's LawB · dl = µ0(Ireal + 0 dE dt ) 6 Must be cool 7 Maxwell's last two equations... B

Tobar, Michael


ISSN 0103-9741 Monografias em Cincia da Computao  

E-print Network

abordagem por reflexão computacional baseada em lógica Dárlinton Barbosa Feres Carvalho Edward Hermann Lucena Dezembro, 2010 Análise de Riscos em Projetos: uma abordagem por reexão computacional baseada em em um projeto, é proposto neste trabalho um modelo para reexão computacional baseado em lógica

Endler, Markus


School Budget Hold'em Facilitator's Guide  

ERIC Educational Resources Information Center

"School Budget Hold'em" is a game designed to help school districts rethink their budgeting process. It evolved out of Education Resource Strategies' (ERS) experience working with large urban districts around the country. "School Budget Hold'em" offers a completely new approach--one that can turn the budgeting process into a long-term visioning…

Education Resource Strategies, 2012



Fully distributed EM for very large datasets  

Microsoft Academic Search

In EM and related algorithms, E-step compu- tations distribute easily, because data items are independent given parameters. For very large data sets, however, even storing all of the parameters in a single node for the M- step can be impractical. We present a frame- work that fully distributes the entire EM pro- cedure. Each node interacts only with pa- rameters

Jason Wolfe; Aria Haghighi; Dan Klein



LANSIM and its applications to distributed EMS  

SciTech Connect

Distributed energy management systems (EMS) open up a host of alternative design options. Simulation plays an important role in evaluating performance and in comparing alternative designs. Currently all the proposed distributed EMSs are local area network (LAN)-based. To illustrate the application of LANSIM, comparisons are made with different distributed EMS configurations, different LAN technologies (Ethernet and FDDI), and different Ethernet implementations.

Lun, S.M.; Lo, T.; Wu, F.; Murphy, L. [Univ. of California, Berkeley, CA (United States). Dept. of Electrical Engineering and Computer Sciences; Sen, A. [ABB Systems Control, Santa Clara, CA (USD)



Em que medida devem ser privados, em que medida devem ser pblicos o conhecimento e a informao?  

E-print Network

Em que medida devem ser privados, em que medida devem ser públicos o conhecimento e a informação? 1 Transparências com licença Creative Commons Em que medida devem ser privados, em que medida devem ser públicos o as alternativas? codexKonstanz #12;Em que medida devem ser privados, em que medida devem ser públicos o

Kuhlen, Rainer


Can psychopharmacological treatment change personality traits in patients with panic disorder? O tratamento psicofarmacológico pode mudar traços de personalidade em pacientes com transtorno do pânico?  

Microsoft Academic Search

Objective: The aim of this study was to evaluate the effects that a particular psychopharmacological treatment has on personality patterns in patients with panic disorder. Method: Forty-seven patients with panic disorder and 40 controls were included in the study. The Mini International Neuropsychiatric Interview and Minnesota Multiphasic Personality Inventory were used to assess Diagnostic and Statistical Manual of Mental Disorders,

Letícia Kipper; Cláudia Wachleski; Giovanni Abrahão Salum; Elizeth Heldt; Carolina Blaya; Gisele Gus Manfro



Efeito de Anestésicos locais com e sem Vasoconstritor em Pacientes com Arritmias Ventriculares effect of Local Anesthetics with and without Vasoconstrictor Agent in Patients with Ventricular Arrhythmias  

Microsoft Academic Search

Summary Background: The routine use of local anesthetics associated to vasoconstrictors for the dental treatment of patients with cardiopathies is still controversial, due to the risk of adverse cardiovascular effects. Objective: To evaluate and compare the hemodynamic effects of the use of local anesthetics with a non-adrenergic vasoconstrictor in patients with ventricular arrhythmia, when compared to the use of anesthetics

Maria Teresa Fernández Cáceres; Ana Cristina; P. P. Ludovice; Fabio Sândoli de Brito; Francisco Carlos Darrieux; Ricardo Simões Neves; Mauricio Ibrahim Scanavacca; Eduardo A. Sosa; Denise Tessariol Hachul



Structures, Molecular Descriptors, Model Development and Biopharmaceutical Property Estimation  

E-print Network

Terbutaline Methyldopa Amoxicillin Atenolol Amoxicillin Terbutaline Furosemide Terbutaline Atenolol Hydrochlorothiazide Atenolol Methyldopa Fluvastatin Metoprolol Metoprolol Ketoprofen Fluvastatin Piroxicam Naproxen Propranolol Propranolol Verapamil...

Bolger, Michael



EM International, July 1994, Volume 2  

SciTech Connect

The Office of Environmental Management (EM) at the Department of Energy (DOE) is seeking out and leveraging foreign technology, data, and resources in keeping with EM`s mandate to protect public health and the environment through the safe and cost-effective remediation of the Department`s nuclear weapons sites. EM works closely with foreign governments, industry, and universities to obtain innovative environmental technologies, scientific and engineering expertise, and operations experience that will support EM`s objectives. Where appropriate, these international resources are used to manage the more urgent risks at our sites, secure a safe workplace, help build consensus on critical issues, and strengthen our technology development program. Through international agreements EM engages in cooperative exchange of information, technology, and individuals. Currently, we are managing agreements with a dozen countries in Europe, Latin America, and Asia. These agreements focus on environmental restoration, waste management, transportation of radioactive wastes, and decontamination and decommissioning. This publication contains the following articles: in situ remediation integrated program; in-situ characterization and inspection of tanks; multimedia environmental pollutant assessment system (MEPAS); LLNL wet oxidation -- AEA technology. Besides these articles, this publication covers: EU activities with Russia; technology transfer activities; and international organization activities.

Not Available



Žem?s ?kio gamybos (ekologin?s ir ?prastin?s) ?taka dirvožemio savyb?ms ir žiemini? kvie?i? gr?d? kokybei.  

E-print Network

??Tyrimai atlikti 2008–2009 m. Lietuvos žem?s ?kio universiteto Agroekologijos centro ekologin?s gamybos ir mokomajame (chemizuota gamyba) ?kiuose. Darbo tikslas - ?vertinti ekologin?s žem?s ?kio gamybos… (more)

Užpurvis,; Edgaras



EMS offshore. A new horizon for paramedics.  


The difficulty in getting medical aid to offshore drilling platforms can be a source of life-threatening delays. Recently, some companies have charted new waters by actually stationing EMS crews on their rigs. PMID:10116023

Mallard, A S



EMS Division Potential Benefits of Selected  

E-print Network

Engineers Journal, January 1998, p 107 2 D. Kuhlmann-Wilsdorf, "Metal Fiber Brushes", in Electrical Contacts coils are stationary; there are no rotating cold seals #12;EMS Division Advanced Homopolar Motor Concept


Revisão sistemática sobre obesidade em adolescentes brasileiros  

Microsoft Academic Search

Resumo - O propósito deste estudo foi revisar, de forma sistemática, a literatura nacional sobre a prevalência e fatores associados à obesidade em adolescentes. A busca foi realizada nas bases de dados Pubmed e Bireme, através dos descritores: \\

Rafael Miranda Tassitano; Maria Cecília Marinho Tenório; Pedro C Hallal


M em ory for Item s and M em ory for R elations in the Procedural/D eclarative M em ory Fram ew ork  

E-print Network

ever, as we hope to m ake clear here, progress on this front M E M O R Y , 1 99 7, 5 (1 /2 ), 1 31 ±17M em ory for Item s and M em ory for R elations in the Procedural/D eclarative M em ory Fram ew ork ard Eichenbaum Boston U niversity, U SA A m ajor area of research in m em ory and am nesia concerns

Poldrack, Russ


Avaliação da qualidade de vida em paciente com espondilite anquilosante após tratamento em piscina terapêutica Evaluate quality of the life in patient with anquilosante espondilite after therapy in swimming pool  

Microsoft Academic Search

Objective: to evaluate the influence of the therapy in swimming pool in the quality of the life and flexibility in carrying patient of anquilosante espondilite (EA). Methods: a patient of 50 years of age was triado, with time of 20 years of evolution of the illness, in the Clinic of the São Paulo University Unip, after to present eligibility for

Fernanda Degilio Alves; Daiane Fiorina Spalvieri; Danielle Alves Silva; Thiago Stakflett; Prado Aline


Soroprevalência da infecção pelo vírus da imunodeficiência humana em pacientes com tuberculose, em Londrina, Paraná* Human immunodeficiency virus seroprevalence in patients with tuberculosis in the city of Londrina, in the state of Paraná, Brazil  

Microsoft Academic Search

Objective: To estimate the prevalence of human immunodeficiency virus seropositivity among patients with active tuberculosis residing in the city of Londrina, in the state of Paraná, Brazil and treated at the Pulmonology Clinic of the 17th Regional Health Facility of the State of Paraná, and to compare those coinfected with human immunodeficiency virus to those with active tuberculosis only in




Charge, from EM fields only  

E-print Network

Consider the electric field E about an electron. Its source has been thought a substance called charge, enclosed within a small volume that defines the size of the electron. Scattering experiments find no size at all. Charge is useful, but mysterious. This study concludes that charge is not real. Useful, but not real. Absent real charge, the electric field must look to a different source. We know another electric field, vxB, not sourced by charge. A simple model of the electron, using EM fields only, has been found that generates an electric field vxB very like E. Gauss' law finds the model contains charge, but div vxB cannot find the charge density. The model contains a permanent magnetic flux quantum, configured as a dipole. The dipolar B fields spin around the symmetry axis, accounting for angular momentum. Spin stabilizes the magnetic flux quantum, and creates the vxB electric field. Stability in this model is dynamic. Energy is exchanged between the dipolar magnetic moment and an encircling toroidal displacement current, at the Compton frequency, mc^2/h = 1.24x10^20 Hz. The electric field undulates at this rate, instead of being static like E associated with charge. Absent any real charge, we have to abandon the notion that size of a charged particle is that of a small sack full of charge. The only electric field is vxB, and its source is not charge. What is the size of an electron? Coulomb scattering finds it point-like, but its spinning B fields extend to infinity.

R. L. Collins



EMS adaptation for climate change  

NASA Astrophysics Data System (ADS)

The purpose of this study was to find an appropriate scenario of pre-hospital transportation of an emergency medical service (EMS) system for burdensome casualties resulting from extreme climate events. A case of natural catastrophic events in Taiwan, 88 wind-caused disasters, was reviewed and analyzed. A sequential-conveyance method was designed to shorten the casualty transportation time and to promote the efficiency of ambulance services. A proposed mobile emergency medical center was first constructed in a safe area, but nearby the disaster area. The Center consists of professional medical personnel who process the triage of incoming patients and take care of casualties with minor injuries. Ambulances in the Center were ready to sequentially convey the casualties with severer conditions to an assigned hospital that is distant from the disaster area for further treatment. The study suggests that if we could construct a spacious and well-equipped mobile emergency medical center, only a small portion of casualties would need to be transferred to distant hospitals. This would reduce the over-crowding problem in hospital ERs. First-line ambulances only reciprocated between the mobile emergency medical center and the disaster area, saving time and shortening the working distances. Second-line ambulances were highly regulated between the mobile emergency medical center and requested hospitals. The ambulance service of the sequential-conveyance method was found to be more efficient than the conventional method and was concluded to be more profitable and reasonable on paper in adapting to climate change. Therefore, additional practical work should be launched to collect more precise quantitative data.

Pan, C.; Chang, Y.; Wen, J.; Tsai, M.



Tour of the Electromagnetic Spectrum (EMS) Videos  

NSDL National Science Digital Library

These videos introduce middle- and high school-age learners to the electromagnetic spectrum. The product consists of 8 animations including an introduction to electromagnetic waves and one animation for each wavelength of the EM spectrum (Radio, Microwave, Infrared, Visible, Ultraviolet, X-Rays and Gamma Rays). Each wavelength of the EM spectrum offers a construct to illustrate and teach about NASA sensors, missions, and science. Emphasis is placed on relevant science, such as lunar exploration, and hot science topics, such as climate change. The examples and narrative for each wavelength animation build on the learners’ prior knowledge then introduces examples from NASA missions. These examples explore the use of spectral analysis and visualizations that help scientists make discoveries about the world around us using EM waves.

Troy Benesch



EM-ONE : an architecture for reflective commonsense thinking  

E-print Network

This thesis describes EM-ONE, an architecture for commonsense thinking capable of reflective reasoning about situations involving physical, social, and mental dimensions. EM-ONE uses as its knowledge base a library of ...

Singh, Pushpinder, 1972-2006.



ECE 341: Electromagnetic Fields I EM devices and systems  

E-print Network

in material media - Electromagnetic induction - Inductance - Magnetic energy Applications: - ElectronicsECE 341: Electromagnetic Fields I EM devices and systems - Can compute and analyze potentials compositions - Can evaluate capacitance, inductance, resistance, and conductance of EM structures - Understands

Schumacher, Russ


EM2: A Scalable Shared-Memory Multicore Architecture  

E-print Network

We introduce the Execution Migration Machine (EM2), a novel, scalable shared-memory architecture for large-scale multicores constrained by off-chip memory bandwidth. EM2 reduces cache miss rates, and consequently off-chip ...

Khan, Omer



INFORMED CONSENT FOR ALLERGY IMMUNOTHERAPY Allergy immunotherapy shots contain water extract of pollen mold or dust to which a patient has  

E-print Network

Propranolol Inderal Blocadren Timolol Sectral Cartol Tenoretic Atenolol & Chlorthalidone Corgard Nadolol Tenormin Atenolol Corzide Nadolol & Bendroflumethiazide Timolide Timolol & Hydrochlorthiazide Inderal

Milchberg, Howard


A emissão em 8mm e as bandas de Merrill-Sanford em estrelas carbonadas  

NASA Astrophysics Data System (ADS)

Estrelas carbonadas possuem bandas moleculares em absorção no visível e, no infravermelho (IR) as principais características espectrais se devem a emissão de grãos. Recentemente foi detectada a presença de bandas de SiC2 (Merrill-Sanford, MS) em emissão sendo atribuída à presença de um disco rico em poeira. Neste trabalho analisamos uma amostra de 14 estrelas carbonadas, observadas no telescópio de 1.52 m do ESO em 4 regiões espectrais diferentes, a fim de detectar as bandas de MS em emissão. Nossa amostra é composta de estrelas que apresentam além da emissão em 11.3 mm, outra em 8 mm. Esta última emissão, não usual nestes objetos, tem sido atribuída ou a moléculas de C2H2, ou a um composto sólido ainda indefinido. A detecção de emissões de MS e aquelas no IR, simultaneamente, revelaria um cenário mais complexo que o habitualmente esperado para os ventos destes objetos. No entanto como primeiro resultado, verificamos que as bandas de Merrill-Sanford encontram-se em absorção, não revelando nenhuma conexão com a emissão a 8 mm. Assim, temos duas hipóteses: (a) a emissão a 8 mm se deve à molécula C2H2 ou (b) essa emissão é resultado da emissão térmica de grãos. Testamos a segunda hipótese modelando a amostra com grãos não-homogêneos de SiC e quartzo, o qual emite em aproximadamente 8mm. Este grão seria produzido em uma fase evolutiva anterior a das carbonadas (estrelas S) e por terem uma estrutura cristalina são destruídos apenas na presença de campos de radiação ultravioleta muito intensos. Os modelos para os envoltórios utilizam o método de Monte Carlo para descrever o problema do transporte da radiação. As conclusões deste trabalho são: (1) as bandas de Merrill-Sanford se encontram em absorção, sugerindo um cenário usual para os ventos das estrelas da amostra; (2) neste cenário, a emissão em 8 mm seria resultado de grãos de quartzo com mantos de SiC, indicando que o quartzo poderia sobreviver a fase evolutiva S.

de Mello, A. B.; Lorenz-Martins, S.



7 CFR 759.6 - EM to be made available.  

Code of Federal Regulations, 2014 CFR

... 2014-01-01 2014-01-01 false EM to be made available. 759.6 Section 759...DESIGNATIONS AND NOTIFICATIONS § 759.6 EM to be made available. (a) For purposes of the EM Program under part 764, subpart I, of...



7 CFR 759.6 - EM to be made available.  

Code of Federal Regulations, 2013 CFR

... 2013-01-01 2013-01-01 false EM to be made available. 759.6 Section 759...DESIGNATIONS AND NOTIFICATIONS § 759.6 EM to be made available. (a) For purposes of the EM Program under part 764, subpart I, of...



7 CFR 1945.35 - Special EM loan training.  

Code of Federal Regulations, 2011 CFR

...2011-01-01 2009-01-01 true Special EM loan training. 1945.35 Section 1945...Assistance-General § 1945.35 Special EM loan training. (a) General...completed they will be well qualified to process EM loans without undue delay. The...



7 CFR 1945.35 - Special EM loan training.  

Code of Federal Regulations, 2010 CFR

...2010-01-01 2009-01-01 true Special EM loan training. 1945.35 Section 1945...Assistance-General § 1945.35 Special EM loan training. (a) General...completed they will be well qualified to process EM loans without undue delay. The...



7 CFR 1945.35 - Special EM loan training.  

Code of Federal Regulations, 2012 CFR

...2012-01-01 2012-01-01 false Special EM loan training. 1945.35 Section 1945...Assistance-General § 1945.35 Special EM loan training. (a) General...completed they will be well qualified to process EM loans without undue delay. The...



Bayesian Gaussian Process Classification with the EM-EP Algorithm  

E-print Network

Bayesian Gaussian Process Classification with the EM-EP Algorithm Hyun-Chul Kim and Zoubin of hyperparameters to determine various aspects of the function. Recently, the expectation propagation (EP) approach an approximate EM algorithm, the EM-EP algorithm, to learn both the latent function and the hyperparameters

Ghahramani, Zoubin


On Convergence Properties of the EM Algorithm for Gaussian Mixtures  

Microsoft Academic Search

We build up the mathematical connection between the Expectation-Maximization (EM) algorithm and gradient-based approaches for maximum likelihood learning of finite gaussian mixtures. We show that the EM step in parameter space is obtained from the gradient via a projection matrix P, and we provide an explicit expression for the matrix. We then analyze the convergence of EM in terms of

Lei Xu; Michael I. Jordan



A Structural EM Algorithm for Phylogenetic Inference  

Microsoft Academic Search

A central task in the study of molecular evolution is the reconstruction of a phylogenetic tree from sequences of current-day taxa. The most established approach to tree reconstruction is maximum likelihood (ML) analysis. Unfortunately, searching for the maximum likelihood phylogenetic tree is computationally prohibitive for large data sets. In this paper, we describe a new algorithm that uses Structural EM

Nir Friedman; Matan Ninio; Itsik Pe'er; Tal Pupko



Network Emulation with NetEm  

Microsoft Academic Search

Many protocols and applications perform poorly when exposed to real life networks with delay and packet loss. Often, it is costly and dicult to reproduce Internet behavior in a controlled environment. There are tools avail- able for testing, but they are either expen- sive hardware solutions, proprietary software, or limited research projects. NetEm is a recent enhancement of the trac

Stephen Hemminger


Bolseiros em protesto. "Para a banca milhes,  

E-print Network

segunda vez a candida- tura a bolsa de doutoramento. Em 179 candidatos entraram 12. Ele era o 14.° e acha para os animais já houve dificuldades", diz. David Gomes e Ana Silva, de 23 e 24 anos, estão a começar

Instituto de Sistemas e Robotica


Mercury pollution in the Ems estuary  

NASA Astrophysics Data System (ADS)

From approximately 1960 to 1975 the Ems estuary received several tons of mercury per year from a chlor-alkali plant, a pesticide factory and some minor sources. The discharge has been reduced drastically from 1976 onwards. In 1975 and 1976 measurements were made on the distribution of mercury in the sediment. The horizontal distribution revealed a strong local enrichment of the sediment near the point of discharge. The vertical distribution was found to be in accordance with the local deposition rates. In the water phase no significant change in mercury content from 1975 to 1978/79 could be demonstrated. In 1978/79 a difference between Ems estuary and Dutch Wadden Sea was not significant. In 1978 mercury contents of eelpout Zoarces viviparus in the Ems estuary were about twice as high as in the Wadden Sea. In the Ems estuary a decrease of these contents was found between 1974/75 and 1978. A similar decline in the Wadden Sea may be related to a decreased mercury discharge by the River Rhine.

Essink, K.



de Ps-Graduao em Enfermagem  

E-print Network

/data expedição CPF Nome da mãe/pai Estado civil E-mail Endereço residencial #12;Programa de Pós-Graduação em Dirigir-se ao Banco do Brasil e fazer um depósito para a Agência: 14532 Conta �nica do Tesouro Nacional

Floeter, Sergio Ricardo


Efficient Scanning for EM Based Target Localization  

E-print Network

of the time. 1 Introduction Focused Ion Beam Scanning Electron Microscopes (FIB-SEM) and their ability Image Fig. 1. FIB-SEM Scanning Process. The microscope repeatedly scans the surface of a sample blockEfficient Scanning for EM Based Target Localization Raphael Sznitman, Aurelien Lucchi, Natasa

Fua, Pascal


EM-dissertations completed in 2007  

E-print Network

theme: Computational and Experimental Mechanics Sensing, Monitoring and Control of Laser Based Welding-90-9022179-3 EM research theme: Computational and Experimental Mechanics Thermomechanical fatigue failure;Sensor-guided robotic laser welding Graaf, M.W. de Advisor: J. Meijer; J

Franssen, Michael


College of Engineering EM Engineering Mechanics  

E-print Network

College of Engineering EM Engineering Mechanics KEY: # = new course * = course changed = course; bending of beams; combined loading of members; buckling of columns. Prereq: Registration in the College.Kinematics:cartesianandpolarcoordinatesystems;normalandtangentialcomponents;translatingand rotating reference frames. Kinetics of particles and rigid bodies: laws of motion; work and energy; impulse

MacAdam, Keith



Microsoft Academic Search

1 ABSTRACT:- FREITAS, F.L. DA C.; ALMEIDA, K. DE S.; ZANETTI, A.S.; NASCIMENTO, A.A. DO; MACHADO, C. R.; MACHADO, R.Z. (Species of the genus Eimeria (Apicomplexa: Eimeriidae) in giant anteaters (Myrmecophaga tridactyla Linnaeus, 1758) in captivity). Espécies do gênero Eimeria (Apicomplexa: Eimeriidae) em Tamanduás-bandeira (Myrmecophaga tridactyla Linnaeus, 1758) em cativeiro. Revista Brasileira de Parasitologia Veterinária, v. 15, n. 1, p.




E-print Network

BUSCA LOCAL PARA P´OS-PROCESSAMENTO EM RESULTADOS DE OTIMIZA¸C~AO MULTI-OBJETIVO EM REDES DE FILAS otimiza¸c~ao de redes de filas finitas, a capacidade total do sistema em ´areas de espera deve ser a menor algoritmo simulated annealing foi desenvolvido, especialmente para redes de filas finitas, produzindo solu

Cruz, Frederico


Cerebral hemodynamics in young hypertensive subjects and effects of atenolol treatment  

Microsoft Academic Search

The aim of this study was to evaluate changes in cerebral hemodynamics in young patients with uncomplicated hypertension before and after effective antihypertensive treatment with a beta-blocker drug. Changes in mean flow velocity in the middle cerebral artery from normal condition to hypercapnia were evaluated by means of a transcranial Doppler in 42 hypertensive patients and 21 healthy subjects comparable

Elio Troisi; Antonio Attanasio; Maria Matteis; Maura Bragoni; Bruno C Monaldo; Carlo Caltagirone; Mauro Silvestrini



Effect of amlodipine compared to atenolol on small arteries of previously untreated essential hypertensive patients  

Microsoft Academic Search

In a previous retrospective study, long-term treatment of essential hypertensive patients with a slow-release calcium channel blocker resulted in normal resistance artery structure and endothelial function, which did not occur with a ?-blocker. In the present prospective study, 19 previously untreated essential hypertensive patients (aged 47 ± 2 years, 75% male) were treated for 1 year in a double-blind randomized

Ernesto L Schiffrin; Qian Pu; Jeong Bae Park



Prevention of preeclampsia: a randomized trial of atenolol in hyperdynamic patients before onset of hypertension  

Microsoft Academic Search

Objective: To determine if assessment of maternal hemodynamics could predict women at risk for the development of preeclampsia, if treatment directed at hemodynamic abnormalities before the onset of hypertension could prevent preeclampsia, and if mothers could be treated in a way that protects fetal growth.Methods: A double-blinded, randomized controlled trial was conducted. Subjects were considered to be at risk for

Thomas R Easterling; Debra Brateng; Barbara Schmucker; Zane Brown; Steven P Millard



Randomized comparison of atenolol and fludrocortisone acetate in the treatment of pediatric neurally mediated syncope  

Microsoft Academic Search

Overall, these results indicate that oral treatment of neurally mediated syncope is safe and efficacious. Further randomized trials in children will be required to determine the significance of a placebo effect, as well as potential differences in results related to the mechanism of syncope.

William A. Scott; Giacomo Pongiglione; Burt I. Bromberg; Michael S. Schaffer; Barbara J. Deal; Frank A. Fish; Macdonald Dick



Effect of practolol and atenolol on lysosomal enzyme activity in the rat ventricular myocardium  

Microsoft Academic Search

Free and total activity of five lysosomal enzymes and the ratio between the levels of free and total activity after preincubation of myocardial homogenates for 15-45 min with fl-adrenoblockers, added to the homogenates up to final concentrations of between 1 x 10 -9 and 1 x 10- 5 M, were studied. The center of the chosen range of final concentrations

P. V. Sergeev; N. A. Sysolyatina



Frmions ultra-frios em redes ticas  

E-print Network

Férmions ultra-frios em redes óticas Thereza C de L Paiva Colóquio Interinstitucional CBPF - IMPA - UFF - UFRJ 18 de abril de 2012 #12;Átomos ultrafrios armadilhados Bósons e férmions Redes óticas;Redes óticasRedes óticas #12;Redes óticas Potencial confinante + Potencial periódico + #12;Dimensão 3D

Liu, I-Shih


Transportes em Pas: Portugal  

E-print Network

Comentar artigo Imprimir PDF Enviar a um amigo 09 -10 -2012 Toyota aposta no hidrogénio para ve ículos Plug-in em Paris 21 -08 -2012 Toyota lan ça novo Auris com motoriza ção híbrida 20 -08 -2012 MAN Toyota Veículos híbridos Estatísticas deste artigo Passageiros & Mobilidade voltar Os utilizadores

Instituto de Sistemas e Robotica


TandEM: Titan and Enceladus mission  

Microsoft Academic Search

TandEM was proposed as an L-class (large) mission in response to ESA’s Cosmic Vision 2015–2025 Call, and accepted for further\\u000a studies, with the goal of exploring Titan and Enceladus. The mission concept is to perform in situ investigations of two worlds\\u000a tied together by location and properties, whose remarkable natures have been partly revealed by the ongoing Cassini–Huygens\\u000a mission. These

A. Coustenis; S. K. Atreya; T. Balint; R. H. Brown; M. K. Dougherty; F. Ferri; M. Fulchignoni; D. Gautier; R. A. Gowen; C. A. Griffith; L. I. Gurvits; R. Jaumann; Y. Langevin; M. R. Leese; J. I. Lunine; C. P. McKay; X. Moussas; I. Müller-Wodarg; F. Neubauer; T. C. Owen; F. Raulin; E. C. Sittler; F. Sohl; C. Sotin; G. Tobie; T. Tokano; E. P. Turtle; J.-E. Wahlund; J. H. Waite; K. H. Baines; J. Blamont; A. J. Coates; I. Dandouras; T. Krimigis; E. Lellouch; R. D. Lorenz; A. Morse; C. C. Porco; M. Hirtzig; J. Saur; T. Spilker; J. C. Zarnecki; E. Choi; N. Achilleos; R. Amils; P. Annan; D. H. Atkinson; Y. Bénilan; C. Bertucci; B. Bézard; G. L. Bjoraker; M. Blanc; L. Boireau; J. Bouman; M. T. Capria; E. Chassefière; P. Coll; M. Combes; J. F. Cooper; A. Coradini; F. Crary; T. Cravens; I. A. Daglis; E. de Angelis; C. de Bergh; I. de Pater; C. Dunford; G. Durry; O. Dutuit; D. Fairbrother; F. M. Flasar; A. D. Fortes; R. Frampton; M. Fujimoto; M. Galand; O. Grasset; M. Grott; T. Haltigin; A. Herique; F. Hersant; H. Hussmann; W. Ip; R. Johnson; E. Kallio; S. Kempf; M. Knapmeyer; W. Kofman; R. Koop; T. Kostiuk; N. Krupp; M. Küppers; H. Lammer; L.-M. Lara; P. Lavvas; S. Le Mouélic; S. Lebonnois; S. Ledvina; J. Li; T. A. Livengood; R. M. Lopes; J.-J. Lopez-Moreno; D. Luz; P. R. Mahaffy; U. Mall; J. Martinez-Frias; B. Marty; T. McCord; C. Menor Salvan; A. Milillo; D. G. Mitchell; R. Modolo; O. Mousis; M. Nakamura; C. D. Neish; C. A. Nixon; D. Nna Mvondo; G. Orton; M. Paetzold; J. Pitman; S. Pogrebenko; W. Pollard; O. Prieto-Ballesteros; P. Rannou; K. Reh; L. Richter; F. T. Robb; R. Rodrigo; S. Rodriguez; P. Romani; M. Ruiz Bermejo; E. T. Sarris; P. Schenk; B. Schmitt; N. Schmitz; D. Schulze-Makuch; K. Schwingenschuh; A. Selig; B. Sicardy; L. Soderblom; L. J. Spilker; D. Stam; A. Steele; K. Stephan; D. F. Strobel; K. Szego; C. Szopa; R. Thissen; M. G. Tomasko; D. Toublanc; H. Vali; I. Vardavas; V. Vuitton; R. A. West; R. Yelle; E. F. Young



TandEM: Titan and Enceladus mission  

USGS Publications Warehouse

TandEM was proposed as an L-class (large) mission in response to ESA's Cosmic Vision 2015-2025 Call, and accepted for further studies, with the goal of exploring Titan and Enceladus. The mission concept is to perform in situ investigations of two worlds tied together by location and properties, whose remarkable natures have been partly revealed by the ongoing Cassini-Huygens mission. These bodies still hold mysteries requiring a complete exploration using a variety of vehicles and instruments. TandEM is an ambitious mission because its targets are two of the most exciting and challenging bodies in the Solar System. It is designed to build on but exceed the scientific and technological accomplishments of the Cassini-Huygens mission, exploring Titan and Enceladus in ways that are not currently possible (full close-up and in situ coverage over long periods of time). In the current mission architecture, TandEM proposes to deliver two medium-sized spacecraft to the Saturnian system. One spacecraft would be an orbiter with a large host of instruments which would perform several Enceladus flybys and deliver penetrators to its surface before going into a dedicated orbit around Titan alone, while the other spacecraft would carry the Titan in situ investigation components, i.e. a hot-air balloon (Montgolfi??re) and possibly several landing probes to be delivered through the atmosphere. ?? Springer Science + Business Media B.V. 2008.

Coustenis, A.; Atreya, S.K.; Balint, T.; Brown, R.H.; Dougherty, M.K.; Ferri, F.; Fulchignoni, M.; Gautier, D.; Gowen, R.A.; Griffith, C.A.; Gurvits, L.I.; Jaumann, R.; Langevin, Y.; Leese, M.R.; Lunine, J.I.; McKay, C.P.; Moussas, X.; Muller-Wodarg, I.; Neubauer, F.; Owen, T.C.; Raulin, F.; Sittler, E.C.; Sohl, F.; Sotin, C.; Tobie, G.; Tokano, T.; Turtle, E.P.; Wahlund, J.-E.; Waite, J.H.; Baines, K.H.; Blamont, J.; Coates, A.J.; Dandouras, I.; Krimigis, T.; Lellouch, E.; Lorenz, R.D.; Morse, A.; Porco, C.C.; Hirtzig, M.; Saur, J.; Spilker, T.; Zarnecki, J.C.; Choi, E.; Achilleos, N.; Amils, R.; Annan, P.; Atkinson, D.H.; Benilan, Y.; Bertucci, C.; Bezard, B.; Bjoraker, G.L.; Blanc, M.; Boireau, L.; Bouman, J.; Cabane, M.; Capria, M.T.; Chassefiere, E.; Coll, P.; Combes, M.; Cooper, J.F.; Coradini, A.; Crary, F.; Cravens, T.; Daglis, I.A.; de Angelis, E.; De Bergh, C.; de Pater, I.; Dunford, C.; Durry, G.; Dutuit, O.; Fairbrother, D.; Flasar, F.M.; Fortes, A.D.; Frampton, R.; Fujimoto, M.; Galand, M.; Grasset, O.; Grott, M.; Haltigin, T.; Herique, A.; Hersant, F.; Hussmann, H.; Ip, W.; Johnson, R.; Kallio, E.; Kempf, S.; Knapmeyer, M.; Kofman, W.; Koop, R.; Kostiuk, T.; Krupp, N.; Kuppers, M.; Lammer, H.; Lara, L.-M.; Lavvas, P.; Le, Mouelic S.; Lebonnois, S.; Ledvina, S.; Li, J.; Livengood, T.A.; Lopes, R.M.; Lopez-Moreno, J. -J.; Luz, D.; Mahaffy, P.R.; Mall, U.; Martinez-Frias, J.; Marty, B.; McCord, T.; Salvan, C.M.; Milillo, A.; Mitchell, D.G.; Modolo, R.; Mousis, O.; Nakamura, M.; Neish, C.D.; Nixon, C.A.; Mvondo, D.N.; Orton, G.; Paetzold, M.; Pitman, J.; Pogrebenko, S.; Pollard, W.; Prieto-Ballesteros, O.; Rannou, P.; Reh, K.; Richter, L.; Robb, F.T.; Rodrigo, R.; Rodriguez, S.; Romani, P.; Bermejo, M.R.; Sarris, E.T.; Schenk, P.; Schmitt, B.; Schmitz, N.; Schulze-Makuch, D.; Schwingenschuh, K.; Selig, A.; Sicardy, B.; Soderblom, L.; Spilker, L.J.; Stam, D.; Steele, A.; Stephan, K.; Strobel, D.F.; Szego, K.; Szopa



TandEM: Titan and Enceladus mission  

NASA Astrophysics Data System (ADS)

TandEM was proposed as an L-class (large) mission in response to ESA’s Cosmic Vision 2015-2025 Call, and accepted for further studies, with the goal of exploring Titan and Enceladus. The mission concept is to perform in situ investigations of two worlds tied together by location and properties, whose remarkable natures have been partly revealed by the ongoing Cassini-Huygens mission. These bodies still hold mysteries requiring a complete exploration using a variety of vehicles and instruments. TandEM is an ambitious mission because its targets are two of the most exciting and challenging bodies in the Solar System. It is designed to build on but exceed the scientific and technological accomplishments of the Cassini-Huygens mission, exploring Titan and Enceladus in ways that are not currently possible (full close-up and in situ coverage over long periods of time). In the current mission architecture, TandEM proposes to deliver two medium-sized spacecraft to the Saturnian system. One spacecraft would be an orbiter with a large host of instruments which would perform several Enceladus flybys and deliver penetrators to its surface before going into a dedicated orbit around Titan alone, while the other spacecraft would carry the Titan in situ investigation components, i.e. a hot-air balloon (Montgolfière) and possibly several landing probes to be delivered through the atmosphere.

Coustenis, A.; Atreya, S. K.; Balint, T.; Brown, R. H.; Dougherty, M. K.; Ferri, F.; Fulchignoni, M.; Gautier, D.; Gowen, R. A.; Griffith, C. A.; Gurvits, L. I.; Jaumann, R.; Langevin, Y.; Leese, M. R.; Lunine, J. I.; McKay, C. P.; Moussas, X.; Müller-Wodarg, I.; Neubauer, F.; Owen, T. C.; Raulin, F.; Sittler, E. C.; Sohl, F.; Sotin, C.; Tobie, G.; Tokano, T.; Turtle, E. P.; Wahlund, J.-E.; Waite, J. H.; Baines, K. H.; Blamont, J.; Coates, A. J.; Dandouras, I.; Krimigis, T.; Lellouch, E.; Lorenz, R. D.; Morse, A.; Porco, C. C.; Hirtzig, M.; Saur, J.; Spilker, T.; Zarnecki, J. C.; Choi, E.; Achilleos, N.; Amils, R.; Annan, P.; Atkinson, D. H.; Bénilan, Y.; Bertucci, C.; Bézard, B.; Bjoraker, G. L.; Blanc, M.; Boireau, L.; Bouman, J.; Cabane, M.; Capria, M. T.; Chassefière, E.; Coll, P.; Combes, M.; Cooper, J. F.; Coradini, A.; Crary, F.; Cravens, T.; Daglis, I. A.; de Angelis, E.; de Bergh, C.; de Pater, I.; Dunford, C.; Durry, G.; Dutuit, O.; Fairbrother, D.; Flasar, F. M.; Fortes, A. D.; Frampton, R.; Fujimoto, M.; Galand, M.; Grasset, O.; Grott, M.; Haltigin, T.; Herique, A.; Hersant, F.; Hussmann, H.; Ip, W.; Johnson, R.; Kallio, E.; Kempf, S.; Knapmeyer, M.; Kofman, W.; Koop, R.; Kostiuk, T.; Krupp, N.; Küppers, M.; Lammer, H.; Lara, L.-M.; Lavvas, P.; Le Mouélic, S.; Lebonnois, S.; Ledvina, S.; Li, J.; Livengood, T. A.; Lopes, R. M.; Lopez-Moreno, J.-J.; Luz, D.; Mahaffy, P. R.; Mall, U.; Martinez-Frias, J.; Marty, B.; McCord, T.; Menor Salvan, C.; Milillo, A.; Mitchell, D. G.; Modolo, R.; Mousis, O.; Nakamura, M.; Neish, C. D.; Nixon, C. A.; Nna Mvondo, D.; Orton, G.; Paetzold, M.; Pitman, J.; Pogrebenko, S.; Pollard, W.; Prieto-Ballesteros, O.; Rannou, P.; Reh, K.; Richter, L.; Robb, F. T.; Rodrigo, R.; Rodriguez, S.; Romani, P.; Ruiz Bermejo, M.; Sarris, E. T.; Schenk, P.; Schmitt, B.; Schmitz, N.; Schulze-Makuch, D.; Schwingenschuh, K.; Selig, A.; Sicardy, B.; Soderblom, L.; Spilker, L. J.; Stam, D.; Steele, A.; Stephan, K.; Strobel, D. F.; Szego, K.; Szopa, C.; Thissen, R.; Tomasko, M. G.; Toublanc, D.; Vali, H.; Vardavas, I.; Vuitton, V.; West, R. A.; Yelle, R.; Young, E. F.



Complete-data spaces and generalized EM algorithms  

Microsoft Academic Search

Expectation-maximization (EM) algorithms have been applied extensively for computing maximum-likelihood and penalized-likelihood parameter estimates in signal processing applications. Intrinsic to each EM algorithm is a complete-data space (CDS)-a hypothetical set of random variables that is related to the parameters more naturally than the measurements are. The authors describe two generalizations of the EM paradigm: (i) allowing the relationship between the

J. A. Fessler; A. O. Hero



Em18 and Em16, new serologic marker epitopes for alveolar echinococcosis in western blot analysis, are the only two epitopes recognized by commercially available weak positive (cut off) sera for Em2plus-ELISA.  


The assay system for antibody responses against Em2, the most specific antigen for serodiagnosis of alveolar echinococcosis (AE), has been established by enzyme-linked immunosorbent assay (ELISA) but not by Western blot assay, since Em2 antigen is not protein but carbohydrate in nature. Recently we reported that previously undescribed protein epitopes, designated Em18 and Em16 due to their molecular weights, were good serologic markers for AE by Western blot analysis. It has been shown that Em18 and Em16 are the only two epitopes recognized by commercially available weak positive (cut off) sera for the Em2plus-ELISA. PMID:8583132

Ito, A; Osawa, Y; Nakao, M; Horii, T; Okamoto, M; Itoh, M; Yamashita, T



Los NIH anuncian el lanzamiento de 3 estudios integrados de medicina de precisión; ALCHEMIST es para pacientes con ciertos tipos de cáncer de pulmón en estadio inicial

Los Estudios sobre la Secuenciación e Identificación de Marcadores para el Mejoramiento de la Terapia Adjuvante para el Cáncer de Pulmón, conocidos con el nombre de ALCHEMIST, identificarán a pacientes con cáncer de pulmón en estadio inicial cuyos tumores albergan ciertos cambios genéticos, y evaluarán si los tratamientos con medicamentos que actúan sobre esos cambios pueden mejorar la supervivencia.


Planificación de la transición a la atención en la etapa final de la vida para los pacientes de cáncer en estadio avanzado (PDQ®)

Resumen de información revisada por expertos sobre la preparación necesaria por parte de los proveedores de atención de la salud, los pacientes y sus familas para la transición a la etapa final de la vida en los casos de cáncer en estadio avanzado.


Planificación de la transición a la atención en la etapa final de la vida para los pacientes con cáncer en estadio avanzado (PDQ®)

Resumen de información revisada por expertos sobre la preparación necesaria por parte de los proveedores de atención de la salud, los pacientes y sus familas para la transición a la etapa final de la vida en los casos de cáncer en estadio avanzado.



Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. HI PAR (ACQUISITION RADAR) TOWER AND ENLISTED MEN (EM) BARRACKS WITH RADAR ATTACHED. - Nike Hercules Missile Battery Summit Site, Battery Control Administration & Barracks Building, Anchorage, Anchorage, AK


Test beam performance of CDF plug upgrade EM calorimeter  

SciTech Connect

CDF Plug Upgrade(tile-fiber) EM Calorimeter performed resolution of 15%/{radical}E{circle_plus}0.7% with non-linearity less than 1% in a energy range of 5-180 GeV at Fermilab Test Beam. Transverse uniformity of inside-tower-response of the EM Calorimeter was 2.2% with 56 GeV positron, which was reduced to 1.0% with response map correction. We observed 300 photo electron/GeV in the EM Calorimeter. Ratios of EM Calorimeter response to positron beam to that to {sup 137}Cs Source was stable within 1% in the period of 8 months.

Fukui, Y. [National Lab. for High Energy Physics, Tsukuba, Ibaraki (Japan); CDF Upgrade Group



You did what? Clinical errors in EMS.  


It was late and you were exhausted. You ran a call that didn't go the way you would have liked. Errors occurred. What actions do you take when your partner is making mistakes? When do you step in? Do you step in? What if there's more to the errors than you realize? This article provides guidelines for EMS personnel to consider when dealing with a scenario that contains clinical errors. Although not an all-inclusive list, the examples and solutions may be beneficial to providers, including rookies and veterans. PMID:11501273

Linder, G; Murphy, P; Streger, M R



EM threat analysis for wireless systems.  

SciTech Connect

Modern digital radio systems are complex and must be carefully designed, especially when expected to operate in harsh propagation environments. The ability to accurately predict the effects of propagation on wireless radio performance could lead to more efficient radio designs as well as the ability to perform vulnerability analyses before and after system deployment. In this report, the authors--experts in electromagnetic (EM) modeling and wireless communication theory--describe the construction of a simulation environment that is capable of quantifying the effects of wireless propagation on the performance of digital communication.

Burkholder, R. J. (Ohio State University Electroscience Laboratory); Mariano, Robert J.; Schniter, P. (Ohio State University Electroscience Laboratory); Gupta, I. J. (Ohio State University Electroscience Laboratory)



Aquisição de Estreptococos Mutans e Desenvolvimento de Cárie Dental em Primogênitos  

PubMed Central

Objetivo Avaliar o momento de aquisição de estreptococos mutans (EM), desenvolvimento de cárie dental e as variáveis a eles associadas no decorrer de 23 meses, em primogênitos de famílias de baixo nível socioeconômico, desde os sete meses de idade. Método A amostra foi selecionada com base em mães densamente colonizadas por EM, incluindo todos os membros de 14 famílias que conviviam na mesma casa. Foram envolvidos no estudo 14 mães, pais e primogênitos e 8 parentes, na maioria avós. Exames clínicos e radiográficos iniciais determinaram os índices de cárie e condição periodontal dos adultos. Contagens de EM foram feitas em todos os adultos nas duas primeiras visitas. Nas crianças foram avaliados os níveis de EM, o número de dentes e de cáries, em quatro visitas. Resultados A prevalência de EM nos adultos foi alta, estando ausente em apenas um dos pais. EM foram detectados em 1, 2, 3 e 10 crianças, respectivamente nas visitas #1, 2, 3 e 4. A cárie dental foi detectada em apenas três crianças na última visita (aos 30 meses de idade), as quais apresentaram escores de EM significantemente maiores que as crianças sem cárie, na mesma visita. Conclusão Exclusivamente a condição social de baixa renda e mães densamente colonizadas por EM não são sinônimo de colonização precoce e alta atividade de cárie em crianças cuidadas em casa. O desenvolvimento de cárie está significantemente associado a escores elevados de EM nas crianças. PMID:22022218

NOCE, Erica; RUBIRA, Cassia Maria Fischer; da Silva ROSA, Odila Pereira; da SILVA, Salete Moura Bonifácio; BRETZ, Walter Antonio



Rito Funerário entre os Florianopolitanos: corpos em diálogo  

Microsoft Academic Search

Abertura Quando os espanhóis encontraram-se com os ameríndios, o que os livros de história teimam em chamar de descobrimento, cosmologias diferentes foram postas em contato, num processo vigoroso de estranhamento do outro. Cada qual a sua maneira tratou de descobrir quem era este \\

Fernando Gonçalves Bitencourt


Nonlinear Cyclotron-Resonance Accelerations by a Generalized EM Wave  

E-print Network

). Unlike the usual transit-time accelerations e 00 v 1 this acceleration mechanism is independentNonlinear Cyclotron-Resonance Accelerations by a Generalized EM Wave AKIMOTO, Kazuhiro and HOJO accelerations by a 1D, EM, dispersive pulse in an external magnetic field are investigated. It is found

Boyer, Edmond



E-print Network

Sistemas Complexos Física Matemática Fundamentos da Teoria de Conjuntos Nebulosos e da Teoria de Possibilidades Inteligência Artificial Inteligência Computacional e Aplicações Introdução à Teoria de Sistemas Teoria do Controle Inteligente Testes de Software Baseado em Modelo Tópicos Especiais em Computação


Dirio Econmico -Universidades Como ser investigador em Portugal  

E-print Network

Diário Económico - Universidades Como é ser investigador em Portugal Autor: N.D. Editora: ST e SF - Universidades Como é ser investigador em Portugal Autor: N.D. Editora: ST e SF Id: 1646658 Data Publicação: 19

Instituto de Sistemas e Robotica


Stochastic EM-based TFBS motif discovery with MITSU  

PubMed Central

Motivation: The Expectation–Maximization (EM) algorithm has been successfully applied to the problem of transcription factor binding site (TFBS) motif discovery and underlies the most widely used motif discovery algorithms. In the wider field of probabilistic modelling, the stochastic EM (sEM) algorithm has been used to overcome some of the limitations of the EM algorithm; however, the application of sEM to motif discovery has not been fully explored. Results: We present MITSU (Motif discovery by ITerative Sampling and Updating), a novel algorithm for motif discovery, which combines sEM with an improved approximation to the likelihood function, which is unconstrained with regard to the distribution of motif occurrences within the input dataset. The algorithm is evaluated quantitatively on realistic synthetic data and several collections of characterized prokaryotic TFBS motifs and shown to outperform EM and an alternative sEM-based algorithm, particularly in terms of site-level positive predictive value. Availability and implementation: Java executable available for download at, supported on Linux/OS X. Contact: PMID:24931999

Kilpatrick, Alastair M.; Ward, Bruce; Aitken, Stuart



10 CFR Appendixes E-M to Part 52 - [Reserved  

Code of Federal Regulations, 2010 CFR

10 Energy 2 2010-01-01 2010-01-01 false [Reserved] E Appendixes E-M to Part 52 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Appendixes E-M to Part 52...



Notas para uma Avaliação do Discurso Marxista em Douglass North  

Microsoft Academic Search

A partir da publicação do livro Institutions, Institutional Change and Economic Performance em 1990 e da obtenção do Nobel em 1993, as contribuições de Douglass North parecem ter entrado definitivamente no debate sobre a questão do desenvolvimento das economias no longo prazo. Muito se discute atualmente sobre a natureza da obra de North, mais especificamente sobre o grau de neoclassicismo

Gabriel Galípolo; Paulo Gala; Danilo Araujo Fernandes



Tuning of EM performance for streamlined aircraft radomes  

Microsoft Academic Search

Aircraft radomes are often streamlined and highly prone to EM performance degradation due to fabrication uncertainties and the non-uniformity of the constituent radome materials. A novel patching scheme is employed for the enhancement of the EM performance. Besides tuning the performance, this patching scheme can also be employed to determine the potential of the radome for any further improvements.

R. U. Nair; R. M. Jha




Microsoft Academic Search

Introdução Nos últimos anos, a história da ciência vem sendo introduzida em materiais didáticos utilizados em sala de aula. Uma das razões para isso é a pressão de órgãos governamentais, tais como a Secretaria de Educação Básica, responsável pela avaliação destes livros dentro do Programa Nacional de Livros Didáticos para o ens ino fundamental e médio. Os editais destes programas

Cibelle Celestino Silva; Ana Carolina Pimentel


Esparsidade, Estrutura, Escalamento e Estabilidade em Algebra Linear Computacional  

E-print Network

Sparsity, Structure, Scaling and Stability in Computational Linear Algebra - Textbook from the IX School of Computer Science, held on July 24-31 of 1994 at Recife, Brazil. Esparsidade, Estrutura, Escalamento e Estabilidade em Algebra Linear Computacional - Livro texto da IX Escola de Computacao, realizada nos dias 24 a 31 de Julho de 1994 em Recife, Brasil. This textbook is written in Portuguese Language.

Stern, Julio M



Accuracy of EMS Trauma Transport Destination Plans in North Carolina.  


Abstract Objective. Planning for time-sensitive injury may allow emergency medical services (EMS) systems to more accurately triage patients meeting accepted criteria to facilities most capable of providing life-saving treatment. In 2010, North Carolina (NC) implemented statewide Trauma Triage and Destination Plans (TTDPs) in all 100 of North Carolina's county-defined EMS systems. Each system was responsible for identifying the specific destination hospitals with appropriate resources to treat trauma patients. We sought to characterize the accuracy of their hospital designations. Methods. In this cross-sectional study, we collected TTDPs for each county-defined EMS system, including their assigned hospital capabilities (i.e., trauma center or community hospital). We conducted a survey with each EMS system to determine how their TTDP was constructed and maintained, as well as with each TTDP-designated hospital to verify their capabilities. We determined the accuracy of the EMS assigned hospital designations by comparing them to the hospital's reported capabilities. Results. The 100 NC EMS systems provided 380 designations for 112 hospitals. TTDPs were created by EMS administrators and medical directors, with only 55% of EMS systems engaging a hospital representative in the plan creation. Compared to the actual hospital capabilities, 97% of the EMS TTDP designations were correct. Twelve hospital designations were incorrect and the majority (10) overestimated hospital capabilities. Of the 100 EMS systems, 7 misclassified hospitals in their TTDP. EMS systems that did not verify their local hospitals' capabilities during TTDP development were more likely to incorrectly categorize a hospital's capabilities (p = 0.001). Conclusions. A small number of EMS systems misclassified hospitals in their TTDP, but most plans accurately reflected hospital capabilities. Misclassification occurred more often in systems that did not consult local hospitals prior to developing their TTDP. The potential of the TTDP to improve communication between EMS agencies and the facilities with which they work has not been fully realized. EMS agencies or systems should verify local hospital capabilities when engaging in destination planning efforts. PMID:24878396

Moss, Chailee; Cowden, Christopher S; Atterton, Laurie Meyer; Arasaratnam, Meredith H; Fernandez, Antonio R; Evarts, Jeff S; Barrier, Brian; Lerner, E Brooke; Mann, N Clay; Lohmeier, Chad; Shofer, Frances S; Brice, Jane H



Acceleration of MAP-EM algorithm via over-relaxation.  


To improve the convergence rate of the effective maximum a posteriori expectation-maximization (MAP-EM) algorithm in tomographic reconstructions, this study proposes a modified MAP-EM which uses an over-relaxation factor to accelerate image reconstruction. The proposed method, called MAP-AEM, is evaluated and compared with the results for MAP-EM and for an ordered-subset algorithm, in terms of the convergence rate and noise properties. The results show that the proposed method converges numerically much faster than MAP-EM and with a speed that is comparable to that for an ordered-subset type method. The proposed method is effective in accelerating MAP-EM tomographic reconstruction. PMID:25465068

Tsai, Yu-Jung; Huang, Hsuan-Ming; Fang, Yu-Hua Dean; Chang, Shi-Ing; Hsiao, Ing-Tsung



Dor em membros em um serviço de reumatologia pediátrica Limb pain in a pediatric rheumatology outpatient clinic  

Microsoft Academic Search

Objetivo: Avaliar clínica e laboratorialmente crianças e adolescentes com dor em membros e sua possível associação com fibromialgia e hipermobilidade articular. Método: Estudo transversal realizado no período de janeiro de 2001 a dezembro de 2002, que incluiu 103 crianças e ado- lescentes atendidos no Ambulatório de Reumatologia Pediá- trica, com queixa de dor em membros. Além do exame físico geral,

Cássia Maria; P. L. Barbosa; Luciana Hangai; Maria Teresa Terreri; Cláudio Arnaldo Len; Maria Odete; E. Hilário


Estudo comparativo dos parâmetros angulares da marcha humana em ambiente aquático e terrestre em indivíduos hígidos adultos jovens  

Microsoft Academic Search

RESUMO Há um grande interesse em estudar o movimento humano den- tro da água, uma vez que o meio já é utilizado para treinamento e reabilitação devido às diferentes propriedades mecânicas que ofe- rece. No entanto, há uma carência de estudos sobre as caracterís- ticas biomecânicas do andar em ambiente aquático. O presente estudo teve como objetivo determinar as variáveis

Danieli Isabel Romanovitch Ribas; Vera Lúcia Israel; Elisângela Ferretti Manfra; Camila Costa de Araújo



The Post-LBV Supernova 2001em  

NASA Astrophysics Data System (ADS)

The supernova (SN) 2001em in UGC 11794 was classified early as Type Ib/c, i.e., as one arising from a hydrogen-stripped star. As part of a radio survey with the Very Large Array of SNe Ib/c at late times (Stockdale et al. 2003, BAAS, 35, 1346), SN 2001em was detected as a highly luminous radio source ˜2 years after explosion. The SN was also subsequently discovered with Chandra to be a very luminous X-ray source. The properties of both the radio and X-ray emission are more characteristic of the Type II-narrow (IIn) SNe, where the SN shock is interacting with dense, massive circumstellar matter, resulting in bright radio synchrotron emission and thermal bremsstrahlung from the interaction region. In fact, SN 2001em has shown to have spectroscopically transformed to a SN IIn. The premise that this might indicate an off-axis gamma-ray burst has been presented (Granot & Ramirez-Ruiz 2004, ApJ, 609, L9) and later, rather convincingly, refuted (e.g., Schinzel et al. 2009, ApJ, 691, 1380). Chugai & Chevalier (2006, ApJ, 641, 1051) have interpreted the spectral transformation and radio/X-ray emission as the SN shock overtaking the detached hydrogen envelope of the progenitor star, which was shed in a superwind episode many years prior to explosion. Chevalier (2007, RMxAC, 30, 41) has further pointed to the required mass-loss rate in the event being equivalent to what would occur in the eruption of a luminous blue variable (LBV). The optical (ground-based and HST) and radio/X-ray data, together with mid-infrared Spitzer observations, tend to support this scenario of a very massive star that experienced a powerful LBV outburst prior to explosion. Such an event may not be unique, with possible parallels in the cases of SNe 2005bf and 2006jc, and may provide valuable new information about massive stellar evolution.

Van Dyk, Schuyler D.; Chornock, R.; Filippenko, A. V.; Foley, R. J.; Lewin, W. H. G.; Li, W.; Panagia, N.; Pooley, D.; Stockdale, C. J.; Weiler, K. W.



Electromagnetic optimization of EMS-MAGLEV systems  

SciTech Connect

In EMS-MAGLEV high-speed transport systems, devices for propulsion, levitation and contactless on-board electric power transfer are combined in a single electromagnetic structure. The strong coupling among the windings affects the performance of each device and requires the utilization of numerical codes. The paper describes an overall optimization procedure, based on a suitable mathematical model of the system, which takes into account several items of the system performance. The parameters of the model are calculated by an automated sequence of FEM analyses of the configuration. Both the linear generator output characteristics and the propulsion force ripple are improved applying the procedure to a reference configuration. The results are compared with the results obtained by a sequence of partial optimizations operating separately on two different subsets of the geometric parameters.

Andriollo, M.; Martinelli, G.; Morini, A.; Tortella, A. [Univ. of Padova (Italy). Dept. of Electrical Engineering] [Univ. of Padova (Italy). Dept. of Electrical Engineering



DOE EM industry programs robotics development  

SciTech Connect

The Office of Science and Technology (OST) manages an aggressive program for RD&D, as well as testing and evaluation for the U.S. Department of Energy`s (DOE) Environmental Management (EM) organization. The goal is to develop new and improved environmental restoration and waste management technologies to clean up the inventory of the DOE weapons complex faster, safer, and cheaper than is possible with currently available technologies. OST has organized technology management activities along focus teams for each major problem area. There are currently five focus areas: decontamination and decommissioning, tanks, subsurface contaminants, mixed waste, and plutonium. In addition, OST is pursuing research and development (R&D) that cuts across these focus areas by having applications in two or more focus areas. Currently, there are three cross-cutting programs: the robotics technology development; characterization, monitoring, and sensor technologies; and efficient separations and processing.

Staubly, R.; Kothari, V. [Dept. of Energy, Morgantown, WV (United States)



Estudo sobre qualidade de vida com pacientes pós-TMO: aplicação do questionário WHOQOL-Bref Study on quality of life of post-BMT patients: application of WHOQOL-Bref questionnaire Estudio de la calidad de vida de pacientes de post-TMO: aplicación del cuestionario WHOQOL-Bref  

Microsoft Academic Search

RESuMO: O presente trabalho teve por objetivo avaliar a qualidade de vida de pacientes submetidos ao transplante de medula óssea utilizando-se um questionário de avaliação de qualidade de vida, e refletir sobre as contribuições deste instrumento para a compreensão do impacto da doença na vida destes sujeitos, bem como a utilidade destes indicadores para formular e fundamentar o raciocínio clínico

Maria da Conceição dos Santos; Fernanda de Castro Ferreira; Silva Moreira; Marina Ribeiro Rodrigues


Elevated ethyl methanesulfonate (EMS) in nelfinavir mesylate (Viracept, Roche): overview.  


Roche's protease inhibitor nelfinavir mesylate (Viracept) produced between March 2007-June 2007 was found to contain elevated levels of ethyl methanesulfonate (EMS), a known mutagen (alkylator) - leading to a global recall of the drug. EMS levels in a daily dose (2,500 mg Viracept/day) were predicted not to exceed a dose of approximately 2.75 mg/day (approximately 0.055 mg/kg/day based on 50 kg patient). As existing toxicology data on EMS did not permit an adequate patient risk assessment, a comprehensive animal toxicology evaluation of EMS was conducted. General toxicity of EMS was investigated in rats over 28 days. Two studies for DNA damage were performed in mice; chromosomal damage was assessed using a micronucleus assay and gene mutations were detected using the MutaMouse transgenic model. In addition, experiments designed to extrapolate animal exposure to humans were undertaken. A general toxicity study showed that the toxicity of EMS occurred only at doses >or= 60 mg/kg/day, which is far above that received by patients. Studies for chromosomal damage and mutations in mice demonstrated a clear threshold effect with EMS at 25 mg/kg/day, under chronic dosing conditions. Exposure analysis (Cmax) demonstrated that approximately 370-fold higher levels of EMS than that ingested by patients, are needed to saturate known, highly conserved, error-free, mammalian DNA repair mechanisms for alkylation. In summary, animal studies suggested that patients who took nelfinavir mesylate with elevated levels of EMS are at no increased risk for carcinogenicity or teratogenicity over their background risk, since mutations are prerequisites for such downstream events. These findings are potentially relevant to >40 marketed drugs that are mesylate salts. PMID:19660105

Pozniak, Anton; Müller, Lutz; Salgo, Miklos; Jones, Judith K; Larson, Peter; Tweats, David



Queda dos homicídios em São Paulo, Brasil: uma análise descritiva  

PubMed Central

Objetivo Descrever a evolução da mortalidade por homicídios no Município de São Paulo segundo tipo de arma, sexo, raça ou cor, idade e áreas de exclusão/inclusão social entre 1996 e 2008. Métodos Estudo ecológico de série temporal. Os dados sobre óbitos ocorridos no Município foram coletados da base de dados do Programa de Aprimoramento das Informações sobre Mortalidade, seguindo a Classificação Internacional de Doenças, Décima Revisão (CID-10). Foram calculadas as taxas de mortalidade por homicídio (TMH) para a população total, por sexo, raça ou cor, faixa etária, tipo de arma e área de exclusão/inclusão social. As TMH foram padronizadas por idade pelo método direto. Foram calculados os percentuais de variação no período estudado. Para as áreas de exclusão/inclusão social foram calculados os riscos relativos de morte por homicídio. Resultados As TMH apresentaram queda de 73,7% entre 2001 e 2008. Foi observada redução da TMH em todos os grupos analisados, mais pronunciada em homens (?74,5%), jovens de 15 a 24 anos (?78,0%) e moradores de áreas de exclusão social extrema (?79,3%). A redução ocorreu, sobretudo, nos homicídios cometidos com armas de fogo (?74,1%). O risco relativo de morte por homicídio nas áreas de exclusão extrema (tendo como referência áreas com algum grau de exclusão social) foi de 2,77 em 1996, 3,9 em 2001 e 2,13 em 2008. Nas áreas de alta exclusão social, o risco relativo foi de 2,07 em 1996 e 1,96 em 2008. Conclusões Para compreender a redução dos homicídios no Município, é importante considerar macrodeterminantes que atingem todo o Município e todos os subgrupos populacionais e microdeterminantes que atuam localmente, influenciando de forma diferenciada os homicídios com armas de fogo e os homicídios na população jovem, no sexo masculino e em residentes em áreas de alta exclusão social. PMID:21390415

Peres, Maria Fernanda Tourinho; Vicentin, Diego; Nery, Marcelo Batista; de Lima, Renato Sérgio; de Souza, Edinilsa Ramos; Cerda, Magdalena; Cardia, Nancy; Adorno, e Sérgio



Evaluation of Fracture Azimuth by EM Wave and Elastic Wave  

NASA Astrophysics Data System (ADS)

Fracture system plays an important role in the development of underground energy, for example enhanced geothermal system (EGS), oil shale and shale gas, etc. Therefore, it becomes more and more important to detect and evaluate the fracture system. Geophysical prospecting is an useful method to evaluate the characteristics of the subsurface fractures. Currently, micro-seismology, multi-wave seismic exploration, and electromagnetic (EM) survey are reported to be used for the purpose. We are studying a method using both elastic wave and EM wave to detect and evaluate the fracture azimuth in laboratory. First, we build a 3D horizontal transverse isotropy (HTI) model, shown in the figure 1, by dry parallel fractures system, which was constructed by plexiglass plates and papers. Then, we used the ultrasonic system to obtain reflected S-wave data. Depending on the shear wave splitting, we evaluated the fracture azimuth by the algorithm of Pearson correlation coefficient. In addition, we used the full Polarimetric ultra wide band electromagnetic (FP-UWB-EM) wave System, shown in the figure 2, to obtain full polarimetric reflected EM-wave data. Depending on the rotation of the EM wave polarimetry, we evaluated the fracture azimuth by the the ration between maximum amplitude of co-polarimetric EM wave and maximum amplitude of cross-polarimetric EM wave. Finally, we used both EM-wave data and S-wave data to evaluate the fracture azimuth by the method of cross plot and statistical mathematics. To sum up, we found that FP-UWB-EM wave can be used to evaluated the fracture azimuth and is more accurate than ultrasound wave. Also joint evaluation using both data could improve the precision.

Feng, X.; Wang, Q.; Liu, C.; Lu, Q.; Zeng, Z.; Liang, W.; Yu, Y.; Ren, Q.



Theory of EM monitoring of sea bottom geothermal areas  

NASA Astrophysics Data System (ADS)

Monitoring of geophysical conditions of marine sedimentary basins is necessary for predicting seismic events and for adaptation of geothermal technologies for seismically active (as a rule) sea bottom geothermal areas. These conditions are characterized by seismo-hydro-electromagnetic (EM) geophysical field interaction in the presence of gravity. Based on the main physical principles, geophysical and petrophysical data, we formulate a mathematical model of seismo-hydro-EM interaction in a basin of a marginal sea and calculate the transformation of a seismic excitation in the upper mantle under the central part of the sea of Japan into the low-frequency (0.1 to 10 Hz) EM signals at the top of the sea bottom sedimentary layer, at the sea surface and in the atmosphere up to the lower boundary of the ionosphere. Physics of the EM generation and propagation process is shown including: generation of EM waves in the upper mantle layer M by a seismic wave from under M, spatial modulation of diffusive EM waves by a seismic wave, stopping of the EM wave arrived (before the seismic P wave) from the upper mantle at the top of the sediments because of the high electric conductivity of seawater (3.5 S/m), immediate penetration of the EM wave through the seawater thickness after the delayed seismic P wave shock into the sea bottom, and EM emission from the sea surface into the atmosphere. Let us note that the EM signal in the sea bottom sediments is the first measurable signal of a seismic activation of geological structures beneath the seafloor and this signal is protected by seawater from the influence ionosphere disturbances. Amplitude of the computed magnetic signals (300, 200, 50, and 30 pT at the ocean-atmosphere interface and at the height of 10, 30 and 50 km, respectively), their predominant frequency (0.25 Hz), the delay of the seismic P wave in regard to the magnetic signal for the receivers at the shore (20 s), the amplitude of temperature disturbances in sediments (up to 0.02 K), the parameters of the long (150 km) tsunami wave of a small (up to 20 cm) amplitude far from the shore and other values that characterize the seismo-hydro-EM process are of the orders observed. Recommendations for the EM monitoring of dynamic processes beneath seafloor geothermal areas are given.

Ershov, Sergey; Mikhaylovskaya, Irina; Novik, Oleg




E-print Network

Experiência profissional em comunicação 5 Produção científica na área de comunicação (artigos, livros e capítulos) 10 Produção científica em outras áreas de conhecimento (artigos, livros e capítulos) 5 (artigos, livros e 10 #12;3 capítulos) Produção científica em outras áreas de conhecimento (artigos, livros

Maier, Rudolf Richard


Environmental Education and Development Division (EM-522). Annual report, Fiscal year 1993  

SciTech Connect

The Environmental Education and Development Division (EM-522) is one of three divisions within the Office of Technology Integration and Environmental Education and Development (EM-52) in Environmental Restoration and Waste Management`s (EM`s) Office of Technology Development (EM-50). The primary design criterion for EM-522 education activities is directly related to meeting EM`s goal of environmental compliance on an accelerated basis and cleanup of the 1989 inventory of inactive sites and facilities by the year 2019. Therefore, EM-522`s efforts are directed specifically toward stimulating knowledge and capabilities to achieve the goals of EM while contributing to DOE`s overall goal of increasing scientific, mathematical, and technical literacy and competency. This report discusses fiscal year 1993 activities.

Not Available



Truncated and constrained helical analogs of antimicrobial esculentin-2EM.  


Esculentin-2EM is a 37-residue, cationic, amphipathic, ?-helical antimicrobial peptide isolated from a Korean frog, Glandirama emeljanovi. Many studies revealed that truncation of this peptide results in substantial decreases in its antimicrobial activity. Lee and his colleagues have recently reported that a 23-residue esculentin-2EM analog containing a tryptophanyl substitution at position 16 showed a significant recovery of the antimicrobial activity of the parent peptide. Here we report a new series of 15-residue esculentin-2EM analogs which are constrained into an ?-helical conformation via an oct-4-enyl cross-link. The resulting 'stapled' derivatives displayed remarkable increases not only in antimicrobial activity but also in helical content and protease resistance compared to Lee's original 23-residue esculentin-2EM analog. The preliminary data obtained in this work strongly supports the potential of our strategy for the development of a new class of peptide antibiotics. PMID:24211019

Pham, Thanh Kim; Kim, Do-Hee; Lee, Bong-Jin; Kim, Young-Woo



Genética de populações e relações de parentesco em Ciconiiformes (Aves).  

E-print Network

??Estudos de genética de populações e de parentesco genético foram desenvolvidos em colhereiro (Platalea ajaja), cabeça-seca (Mycteria americana) e garça-branca-grande (Ardea alba egretta), de colônias… (more)

Carolina Isabel Miño



Structure of Matter, Forces, EM Waves, Spectroscopy, Doppler Effect  

NSDL National Science Digital Library

These supplemental class notes cover the basic properties of matter, the nature of forces, the electromagnetic spectrum, and how astronomers exploit the properties of the EM spectrum to deduce the physical nature of distant objects.

O'Connell, Robert



E.M. and Hadronic Shower Simulation with FLUKA  

SciTech Connect

A description of the main features of e.m. and hadronic shower simulation models used in the FLUKA code is summarized and some recent applications are discussed. The general status of the FLUKA project is also reported.

Battistoni, G.; Fasso, A.; Ferrari, A.; Ranft, J.; Rubbia, A.; Sala, P.R.; /INFN, Milan /SLAC /CERN /Siegen U. /Zurich, ETH



NASA EM Followup of LIGO-Virgo Candidate Events  

NASA Technical Reports Server (NTRS)

We present a strategy for a follow-up of LIGO-Virgo candidate events using offline survey data from several NASA high-energy photon instruments aboard RXTE, Swift, and Fermi. Time and sky-location information provided by the GW trigger allows for a targeted search for prompt and afterglow EM signals. In doing so, we expect to be sensitive to signals which are too weak to be publicly reported as astrophysical EM events.

Blackburn, Lindy L.



EM Telemetry Tool for Deep Well Drilling Applications  

SciTech Connect

This final report discusses the successful development and testing of a deep operational electromagnetic (EM) telemetry system, produced under a cooperative agreement with the United States Department of Energy's National Energy Technology Laboratory. This new electromagnetic telemetry system provides a wireless communication link between sensors deployed deep within oil and gas wells and data acquisition equipment located on the earth's surface. EM based wireless telemetry is a highly appropriate technology for oil and gas exploration in that it avoids the need for thousands of feet of wired connections. In order to achieve the project performance objectives, significant improvements over existing EM telemetry systems were made. These improvements included the development of new technologies that have improved the reliability of the communications link while extending operational depth. A key element of the new design is the incorporation of a data-fusion methodology which enhances the communication receiver's ability to extract very weak signals from large amounts of ambient environmental noise. This innovative data-fusion receiver based system adapts advanced technologies, not normally associated with low-frequency communications, and makes them work within the harsh drilling environments associated with the energy exploration market. Every element of a traditional EM telemetry system design, from power efficiency to reliability, has been addressed. The data fusion based EM telemetry system developed during this project is anticipated to provide an EM tool capability that will impact both onshore and offshore oil and gas exploration operations, for conventional and underbalanced drilling applications.

Jeffrey M. Gabelmann



Evaluation of Use of Recombinant Em18 and Affinity-Purified Em18 for Serological Differentiation of Alveolar Echinococcosis from Cystic Echinococcosis and Other Parasitic Infections  

Microsoft Academic Search

To further evaluate recombinant Em18 antigen (rEm18) for immunodiagnosis of human alveolar echino- coccosis, 208 serum samples were examined by enzyme-linked immunosorbent assay (ELISA). To compara- tively assess the results of rEm18-ELISA, ELISA and immunoblot analysis with two affinity-purified native antigens were also performed with 45 selected serum samples. The results indicate that rEm18 is highly useful for serodiagnosis.

Ning Xiao; Wulamu Mamuti; Hiroshi Yamasaki; Yasuhito Sako; Minoru Nakao; Kazuhiro Nakaya; Bruno Gottstein; Peter M. Schantz; Marshall W. Lightowlers; Philip S. Craig; Akira Ito



Isolamento de Salmonella spp. em pombos (Columba livia) no Distrito Federal : aspecto de relevância ao sistema de vigilância em saúde.  

E-print Network

??Dissertação (mestrado)—Universidade de Brasília, Faculdade de Agronomia e Medicina Veterinária, Programa de Pós-Graduação em Saúde Animal, 2014. A domesticação de pombos da espécie Columba livia,… (more)

Santos, Ivanildo de Oliveira Correia



DOE EM industry programs robotics development  

SciTech Connect

The Office of Science and Technology (OST) manages an aggressive program for RD and D, as well as testing and evaluation for the Department of Energy`s (DOE`s) Environmental Management (EM) organization. The goal is to develop new and improved environmental restoration and waste management technologies to clean up the inventory of the DOE weapons complex faster, safer, and cheaper than is possible with currently available technologies. Robotic systems reduce worker exposure to the absolute minimum, while providing proven, cost-effective, and, for some applications, the only acceptable technique for addressing challenging problems. Development of robotic systems for remote operations occurs in three main categories: tank waste characterization and retrieval; decontamination and dismantlement; and characterization, mapping, and inspection systems. In addition, the Federal Energy Technology Center (FETC) has some other projects which fall under the heading of supporting R and D. The central objective of all FETC robotic projects is to make robotic systems more attractive by reducing costs and health risks associated with the deployment of robotic technologies in the cleanup of the nuclear weapons complex. This will be accomplished through development of robots that are cheaper, faster, safer, and more reliable, as well as more straightforward to modify/adapt and more intuitive to operate with autonomous capabilities and intelligent controls that prevent accidents and optimize task execution.

Staubly, R.; Kothari, V.



Image segmentation by EM-based adaptive pulse coupled neural networks in brain magnetic resonance imaging.  


We propose an automatic hybrid image segmentation model that integrates the statistical expectation maximization (EM) model and the spatial pulse coupled neural network (PCNN) for brain magnetic resonance imaging (MRI) segmentation. In addition, an adaptive mechanism is developed to fine tune the PCNN parameters. The EM model serves two functions: evaluation of the PCNN image segmentation and adaptive adjustment of the PCNN parameters for optimal segmentation. To evaluate the performance of the adaptive EM-PCNN, we use it to segment MR brain image into gray matter (GM), white matter (WM) and cerebrospinal fluid (CSF). The performance of the adaptive EM-PCNN is compared with that of the non-adaptive EM-PCNN, EM, and Bias Corrected Fuzzy C-Means (BCFCM) algorithms. The result is four sets of boundaries for the GM and the brain parenchyma (GM+WM), the two regions of most interest in medical research and clinical applications. Each set of boundaries is compared with the golden standard to evaluate the segmentation performance. The adaptive EM-PCNN significantly outperforms the non-adaptive EM-PCNN, EM, and BCFCM algorithms in gray mater segmentation. In brain parenchyma segmentation, the adaptive EM-PCNN significantly outperforms the BCFCM only. However, the adaptive EM-PCNN is better than the non-adaptive EM-PCNN and EM on average. We conclude that of the three approaches, the adaptive EM-PCNN yields the best results for gray matter and brain parenchyma segmentation. PMID:20042313

Fu, J C; Chen, C C; Chai, J W; Wong, S T C; Li, I C



FitEM2EM--tools for low resolution study of macromolecular assembly and dynamics.  


Studies of the structure and dynamics of macromolecular assemblies often involve comparison of low resolution models obtained using different techniques such as electron microscopy or atomic force microscopy. We present new computational tools for comparing (matching) and docking of low resolution structures, based on shape complementarity. The matched or docked objects are represented by three dimensional grids where the value of each grid point depends on its position with regard to the interior, surface or exterior of the object. The grids are correlated using fast Fourier transformations producing either matches of related objects or docking models depending on the details of the grid representations. The procedures incorporate thickening and smoothing of the surfaces of the objects which effectively compensates for differences in the resolution of the matched/docked objects, circumventing the need for resolution modification. The presented matching tool FitEM2EMin successfully fitted electron microscopy structures obtained at different resolutions, different conformers of the same structure and partial structures, ranking correct matches at the top in every case. The differences between the grid representations of the matched objects can be used to study conformation differences or to characterize the size and shape of substructures. The presented low-to-low docking tool FitEM2EMout ranked the expected models at the top. PMID:18974836

Frankenstein, Ziv; Sperling, Joseph; Sperling, Ruth; Eisenstein, Miriam



Fibrose pulmonar ocupacional, câncer de laringe e pneumonia de repetição em paciente idoso: relato de caso interdisciplinar Occupational lung fibrosis, cancer of the larynx and pneumonia of repetition in an aged patient: an interdisciplinary case study Fibrosis ocupacional del pulmón, cáncer de la laringe y pulmonía a repetición en un paciente envejecido: un estudio de caso interdisciplinario  

Microsoft Academic Search

ReSumO: A fibrose pulmonar apresenta inúmeras complicações sistêmicas, como a desnutrição e a redução da capacidade funcional. O tratamento deve ser indi- vidualizado e desenhado para minimização dos sintomas, otimização do status funcional e redução dos gastos com saúde. Este estudo teve por objetivo avaliar o impacto da abordagem interdisciplinar na reabilitação de idoso com fibrose pulmonar e desnutrição. Trata-se

Débora Rocha Oliveira; Alexandre Luque; Maria Alice de Gouveia Pereira; Andréa de Souza; Vera Silvia Frangella


Degradation of Benzodiazepines after 120 Days of EMS Deployment  

PubMed Central

Introduction EMS treatment of status epilepticus improves outcomes, but the benzodiazepine best suited for EMS use is unclear, given potential high environmental temperature exposures. Objective To describe the degradation of diazepam, lorazepam, and midazolam as a function of temperature exposure and time over 120 days of storage on active EMS units. Methods Study boxes containing vials of diazepam, lorazepam, and midazolam were distributed to 4 active EMS units in each of 2 EMS systems in the southwestern United States during May–August 2011. The boxes logged temperature every minute and were stored in EMS units per local agency policy. Two vials of each drug were removed from each box at 30-day intervals and underwent high-performance liquid chromatography to determine drug concentration. Concentration was analyzed as mean (and 95%CI) percent of initial labeled concentration as a function of time and mean kinetic temperature (MKT). Results 192 samples were collected (2 samples of each drug from each of 4 units per city at 4 time-points). After 120 days, the mean relative concentration (95%CI) of diazepam was 97.0% (95.7–98.2%) and of midazolam was 99.0% (97.7–100.2%). Lorazepam experienced modest degradation by 60 days (95.6% [91.6–99.5%]) and substantial degradation at 90 days (90.3% [85.2-95.4%]) and 120 days (86.5% [80.7–92.3%]). Mean MKT was 31.6°C (95%CI 27.1–36.1). Increasing MKT was associated with greater degradation of lorazepam, but not midazolam or diazepam. Conclusions Midazolam and diazepam experienced minimal degradation throughout 120 days of EMS deployment in high-heat environments. Lorazepam experienced significant degradation over 120 days and appeared especially sensitive to higher MKT exposure. PMID:24548058

McMullan, Jason T.; Jones, Elizabeth; Barnhart, Bruce; Denninghoff, Kurt; Spaite, Daniel; Zaleski, Erin; Silbergleit, Robert



Learning when to Hold'em and When to Fold'em: ERS's Budget Hold'em Game Facilitates the Budget Development Process in Memphis  

ERIC Educational Resources Information Center

If your school district is facing a budget issue, it might surprise you to learn that the solution might very well lie in a game of cards. That certainly was the case earlier this year for the city schools of Memphis, Tennessee. The game is called Budget Hold'em, and it was developed by Education Resource Strategies (ERS) of Watertown,…

Education Resource Strategies, 2010



High prevalence of immunoglobulin A deficiency in patients with type 1 diabetes mellitus detected by ELISA Alta prevalência de deficiência de imunoglobulina A detectada por ELISA em pacientes com diabetes mellitus  

Microsoft Academic Search

Objective: To measure serum levels of immunoglobulin A by immunoenzymatic assay (ELISA) in type 1 diabetes mellitus (DM-1) patients and to verify the prevalence of immunoglobulin A deficiency (IgAD) in diabetic patients. Methods: The serum immunoglobulin A level was determined in 149 DM-1 patients by three methods. IgAD was defined as serum immunoglobulin A level lower than 5 mg\\/dl. If

Loraine Farias Landgraf; Nelson Augusto Rosário; Juliana Ferreira de Moura; Katherine Andrew Wells; Bonald Cavalcanti Figueiredo


Síndrome de Wolff-Parkinson-White e outras Vias Acessórias Atrioventriculares em 1465 Pacientes Submetidos à Ablação por Radiofreqüência Wolff-Parkinson-White Syndrome and other Atrioventricular Accessory Pathways in 1,465 Patients Undergoing Radio-Frequency Ablation  

Microsoft Academic Search

Background: Several studies analyzed clinical and electrophysiological data for patients with accessory pathways, most of them not Brazilian and based on a relatively small number of patients. Objective: To describe the number and location of the accessory pathways in Brazilian patients undergoing radiofrequency ablation. Methods: A retrospective analysis was conducted of 1,465 consecutive patients with accessory pathways who u n

Iara Atié; Washington Maciel; Eduardo Andréa; Nilson Araújo; Hecio Carvalho; Luís Belo; Leonardo Siqueira; Cláudio Munhoz; Rodrigo Cosenza; Fabiana Mitidieri; Lara Fonseca; Cristiane Bortoluzzo; Tarik Arcoverde; Bruno Andréa; Jacob Atié


Prevalência e prognóstico dos pacientes com pneumonia associada à ventilação mecânica em um hospital universitário* Prevalence of ventilator-associated pneumonia in a university hospital and prognosis for the patients affected  

Microsoft Academic Search

Objective: To determine the prevalence of ventilator-associated pneumonia in an intensive care unit, as well as to identify related factors and characterize patient evolution. Methods: This study evaluated 278 patients on mechanical ventilation for more than 24 hours in a university hospital. Results: Ventilator-associated pneumonia developed in 38.1% of the patients, translating to 35.7 cases\\/1000 ventilator- days: 45.3% were caused




EMS Stretcher "Misadventures" in a Large, Urban EMS System: A Descriptive Analysis of Contributing Factors and Resultant Injuries.  


Purpose. There is a paucity of data regarding EMS stretcher-operation-related injuries. This study describes and analyzes characteristics associated with undesirable stretcher operations, with or without resultant injury in a large, urban EMS agency. Methods. In the study agency, all stretcher-related "misadventures" are required to be documented, regardless of whether injury results. All stretcher-related reports between July 1, 2009 and June 30, 2010 were queried in retrospective analysis, avoiding Hawthorne effect in stretcher operations. Results. During the year studied, 129,110 patients were transported. 23 stretcher incidents were reported (0.16 per 1,000 transports). No patient injury occurred. Four EMS providers sustained minor injuries. Among contributing aspects, the most common involved operations surrounding the stretcher-ambulance safety latch, 14/23 (60.9%). From a personnel injury prevention perspective, there exists a significant relationship between combative patients and crew injury related to stretcher operation, Fisher's exact test 0.048. Conclusions. In this large, urban EMS system, the incidence of injury related to stretcher operations in the one-year study period is markedly low, with few personnel injuries and no patient injuries incurred. Safety for EMS personnel and patients could be advanced by educational initiatives that highlight specific events and conditions contributing to stretcher-related adverse events. PMID:22606379

Goodloe, Jeffrey M; Crowder, Christopher J; Arthur, Annette O; Thomas, Stephen H



EMS Stretcher “Misadventures” in a Large, Urban EMS System: A Descriptive Analysis of Contributing Factors and Resultant Injuries  

PubMed Central

Purpose. There is a paucity of data regarding EMS stretcher-operation-related injuries. This study describes and analyzes characteristics associated with undesirable stretcher operations, with or without resultant injury in a large, urban EMS agency. Methods. In the study agency, all stretcher-related “misadventures” are required to be documented, regardless of whether injury results. All stretcher-related reports between July 1, 2009 and June 30, 2010 were queried in retrospective analysis, avoiding Hawthorne effect in stretcher operations. Results. During the year studied, 129,110 patients were transported. 23 stretcher incidents were reported (0.16 per 1,000 transports). No patient injury occurred. Four EMS providers sustained minor injuries. Among contributing aspects, the most common involved operations surrounding the stretcher-ambulance safety latch, 14/23 (60.9%). From a personnel injury prevention perspective, there exists a significant relationship between combative patients and crew injury related to stretcher operation, Fisher's exact test 0.048. Conclusions. In this large, urban EMS system, the incidence of injury related to stretcher operations in the one-year study period is markedly low, with few personnel injuries and no patient injuries incurred. Safety for EMS personnel and patients could be advanced by educational initiatives that highlight specific events and conditions contributing to stretcher-related adverse events. PMID:22606379

Goodloe, Jeffrey M.; Crowder, Christopher J.; Arthur, Annette O.; Thomas, Stephen H.



Analyses of Subnanometer Resolution Cryo-EM Density Maps  

PubMed Central

Today, electron cryomicroscopy (cryo-EM) can routinely achieve subnanometer resolutions of complex macromolecular assemblies. From a density map, one can extract key structural and functional information using a variety of computational analysis tools. At subnanometer resolution, these tools make it possible to isolate individual subunits, identify secondary structures, and accurately fit atomic models. With several cryo-EM studies achieving resolutions beyond 5 Å, computational modeling and feature recognition tools have been employed to construct backbone and atomic models of the protein components directly from a density map. In this chapter, we describe several common classes of computational tools that can be used to analyze and model subnanometer resolution reconstructions from cryo-EM. A general protocol for analyzing subnanometer resolution density maps is presented along with a full description of steps used in analyzing the 4.3 Å resolution structure of Mm-cpn. PMID:20888467

Baker, Matthew L.; Baker, Mariah R.; Hryc, Corey F.; DiMaio, Frank



Residual Symmetries in the Presence of an EM Background  

E-print Network

The symmetry algebra of a QFT in the presence of an external EM background (named "residual symmetry") is investigated within a Lie-algebraic, model independent scheme. Some results previously encountered in the literature are here extended. In particular we compute the symmetry algebra for a constant EM background in D=3 and D=4 dimensions. In D= 3 dimensions the residual symmetry algebra is isomorphic to $u(1)\\oplus {\\cal P}_c(2)$, with ${\\cal P}_c(2)$ the centrally extended 2-dimensional Poincar\\'e algebra. In D=4 dimension the generic residual symmetry algebra is given by a seven-dimensional solvable Lie algebra which is explicitly computed. Residual symmetry algebras are also computed for specific non-constant EM backgrounds.

H. L. Carrion; M. Rojas; F. Toppan



Convergence Results for the EM Approach to Mixtures of Experts Architectures  

E-print Network

The Expectation-Maximization (EM) algorithm is an iterative approach to maximum likelihood parameter estimation. Jordan and Jacobs (1993) recently proposed an EM algorithm for the mixture of experts architecture of ...

Jordan, Michael I.



Estudo de apomixia em diferentes níveis de ploidia no Manihot spp.  

E-print Network

??Dissertação (mestrado)—Universidade de Brasília, Instituto de Ciências Biológicas, Departamento de Botânica, Programa de Pós-Graduação em Botânica, 2011. A apomixia em Manihot vem sendo estudada pelo… (more)

Ferreira, Adalgisa Maria Chaib



EM-31 Alternative and Enhanced Chemical Cleaning Program  

SciTech Connect

King's introduction to his presentation made 5 important points: 1) Numerous SRS tanks scheduled for closure (contract commitments); 2) Cannot remove all sludge by mechanical means due to obstructions; 3) Chemical removal technology needed (likely oxalic acid); 4) Post - dissolution neutralization required prior to transfer to compliant tanks; 5) Sodium oxalate salts precipitate on neutralization and have negative downstream impacts. There were three SRS chemical cleaning programs in 2010: Baseline: 8wt percent OA batch contact, ECC: 1-3 wt. percent OA with oxalate destruction, and the Alternative/Enhanced Chemical Cleaning (EM-31). This talk is on the EM-31 program.

King, Bill (SRNL) [SRNL



ARTIGO INTERNET Jogos Srios em debate no IST  

E-print Network

ARTIGO INTERNET «Jogos Sérios» em debate no IST in Data: 2011-9-15 Link: ... «Jogos Sérios» em debate no IST O Instituto Superior Técnico (IST) vai ser o palco da II Conferência Internacional sobre aplicações e desenvolvimento de «Jogos Sérios» A conferência terá lugar nos dias 19 e 20 de

Instituto de Sistemas e Robotica



E-print Network

transmissíveis (DTs) e agentes etiológicos. História natural da infecção no hospedeiro. Noção de R0. Imunidade de grupo. Construção de modelos matemáticos para DTs: em equações às diferenças. Principais parâmetros dos modelos de DTs e sua estimação. Modelos para DTs formalizados em equações diferenciais. Padrões dinâmicos

Instituto de Sistemas e Robotica


Erros comuns de ingls em artigos cientficos escritos por pessoas de lngua portuguesa  

E-print Network

Erros comuns de inglês em artigos científicos escritos por pessoas de língua portuguesa Siang Wun comuns de inglês em artigos científicos escritos por pessoa #12;Introdução Baseado em experiência acumulada ao longo dos anos, ao revisar artigos escritos em inglês principalmente por pessoas de língua

Song, Siang Wun


Study on the Temperature Limitation of the Injecting Power to a Pyramidal EM-Wave Absorber  

Microsoft Academic Search

In this paper, first the temperature distribution of the pyramidal EM-wave absorber is calculated in the coupled method. Next, the injected power to the EM-wave absorber is changed to estimate the maximum power density that the EM-wave absorber can resist. As a result, the limitation of the injecting power density to a pyramidal EM-wave absorber is achievable.

Tetsuhiro Sasagawa; Shinya Watanabe; Osamu Hashimoto; Toshifumi Saito; Hiroshi Kurihara



Quasi-Monte Carlo Sampling to improve the Efficiency of Monte Carlo EM  

E-print Network

Quasi-Monte Carlo Sampling to improve the Efficiency of Monte Carlo EM Wolfgang Jank November 17, 2003 Abstract In this paper we investigate an efficient implementation of the Monte Carlo EM al- gorithm based on Quasi-Monte Carlo sampling. The Monte Carlo EM algorithm is a stochastic version

Jank, Wolfgang


EMS Mutagenesis 101 From: Methods in Molecular Biology, vol. 323: Arabidopsis Protocols, Second Edition  

E-print Network

-genomic era, the use of reverse genetic approaches to understanding the role of genes in growth of EMS mutagenesis for the molecular genetic model plant Arabidopsis thaliana. Key Words: EMS; chemical produces T/A to G/C transversion and A/T to G/C transitions (1,3,4). At a low frequency, EMS generates G

Schumaker, Karen


Reliable prediction of EM radiation from a PCB at the design stage of electronic equipment  

Microsoft Academic Search

This paper presents a composite computer-aided design (CCAD) package for prediction of electromagnetic (EM) radiation from a printed circuit board (PCB) at the design stage of equipment. Such a CCAD package has been developed by combining an EM computation tool such as numerical electromagnetic code (NEC)-2, with other circuit design packages (CDPs). The method of prediction of EM radiation using

P. K. Saha; Jim Dowling



Convergence results for the EM approach to mixtures of experts architectures  

Microsoft Academic Search

The Expectation-Maximization (EM) algorithm is an iterative approach to maximum likelihood parameter estimation. Jordan and Jacobs recently proposed an EM algorithm for the mixture of experts architecture of Jacobs, Jordan, Nowlan and Hinton (1991) and the hierarchical mixture of experts architecture of Jordan and Jacobs (1992). They showed empirically that the EM algorithm for these architectures yields significantly faster convergence

Michael I. Jordan; Lei Xu



Airborne EM for geothermal and hydrogeological mapping  

NASA Astrophysics Data System (ADS)

Within the "VIGOR" project, aimed at assessing the geothermal potential of four regions in southern Italy, Airborne EM data have been acquired, modeled and interpreted. The system deployed was SkyTEM, a time-domain helicopter electromagnetic system designed for hydrogeophysical, environmental and mineral investigations. The AEM data provide, after data acquisition, analysis, processing, and modeling, a distribution volume of electrical resistivity, spanning an investigation depth from ground surface of few hundred meters, depending on resistivity condition. Resistivity is an important physical parameter for geothermal investigation, since it proved to be very effective in mapping anomalies due to hydrothermal fluid circulation, which usually has high salt content and produces clayey alteration minerals. Since the project required, among other issues, to define geothermal resources at shallow level, it was decided to perform a test with an airborne electromagnetic geophysical survey, to verify the advantages offered by the system in covering large areas in a short time. The geophysical survey was carried out in Sicily, Italy, in late 2011, over two test sites named "Termini" and "Western Sicily". The two areas were chosen on different basis. "Termini" area is covered by extensive geological surveys, and was going to be investigated also by means of electrical tomography in its northern part. Since geological condition of Sicily, even at shallow depth, is very complex, this area provided a good place for defining the resistivity values of the main geological units outcropping in the region. "Termini" survey has been also an occasion to define relations between resistivity distribution, lithological units and thermal conductivity. The "Western Sicily" area cover the main thermal manifestations of western Sicily, and the research target was to establish whether they are characterized by common hydrogeological or tectonic features that could be mapped by resistivity. SkyTEM data have been acquired in a series of flight lines and were then processed and inverted. In the "Termini" area the flight line spacing had 150 m separation. In the "Western Sicily" area two different line spacing were used: the 1 km spacing was used for the regional mapping, whereas for infill areas, around the main hydrothermal springs, the flight lines had 100 m spacing. The total number of flight line was 4580 km, and the explored surface was in excess of 2000 km2. After acquisition, data were processed to eliminate coupling with infrastructures, and noise. Inversions was then carried out using the quasi 3-D Spatially Constrained Inversion. The obtained resistivity volume has then been the base for a detailed lithological and geothermal interpretation. Lithological and geological maps were used to constrain surface condition and to understand the resistivity ranges of the different lithological units. On the base of resistivity values, lithological units were combined to establish the main litho-resistive units, then modeled at depth, down to achievable investigation depth. This detailed interpretative modeling was also the occasion of recognizing resistivity anomalies within carbonate units, which may possibly represent hydrogeological or hydrothermal bodies. The litho-resitive 3D model is now under investigation to verify how it can represent a viable way to image thermal conductivity variations at depth.

Menghini, A.; Manzella, A.; Viezzoli, A.; Montanari, D.; Maggi, S.



Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol  

Microsoft Academic Search

995 Summary Background Blood pressure reduction achieved with ? -blockers and diuretics is the best recorded intervention to date for prevention of cardiovascular morbidity and death in patients with hypertension. Left ventricular hypertrophy (LVH) is a strong independent indicator of risk of cardiovascular morbidity and death. We aimed to establish whether selective blocking of angiotensin II improves LVH beyond reducing

Björn Dahlöf; Richard B Devereux; Sverre E Kjeldsen; Stevo Julius; Gareth Beevers; Ulf de Faire; Frej Fyhrquist; Hans Ibsen; Krister Kristiansson; Ole Lederballe-Pedersen; Lars H Lindholm; Markku S Nieminen; Per Omvik; Suzanne Oparil; Hans Wedel




E-print Network

Computação: 16, sendo 2 para candidatos com residência no exterior. 2.3.2 Linha de Pesquisa em Fundamentos e, Algoritmos e Métodos Formais (3 vagas), Processamento de Imagens e Sinais (7 vagas), Redes e Comunicação sem

Lucero, Jorge Carlos



E-print Network

no exterior. 2.3.2 Linha de Pesquisa em Fundamentos e Métodos de Computação: 15 (quinze), sendo quatro para imagens e sinais (9 vagas), robótica (2 vagas), redes e comunicação sem fio (2 vagas), hardware e sistemas

Maier, Rudolf Richard


Sonar-Based Mapping With Mobile Robots Using EM  

Microsoft Academic Search

This paper presents an algorithms for learn- ing occupancy grid maps with mobile robots equipped with range finders, such as sonar sen- sors. Our approach employs the EM algorithm to solve the concurrent mapping and localization problem. To accommodate the spatial nature of range data, it relies on a two-layered representa- tion of maps, where global maps are composed from

Wolfram Burgard; Dieter Fox; Hauke Jans; Christian Matenar; Sebastian Thrun


ISSN 0103-9741 Monografias em Cincia da Computao  

E-print Network

&P) activities, such as 3D geomodelling, seismic interpretation, real-time drilling follow-up and correction, offshore structures' design, static and dynamic simulations of these offshore structures, oil pipelines perfuração em tempo real, projeto de estruturas offshore, simulações estáticas e dinâmicas destas estruturas

Barbosa, Alberto


Minimum-Distortion Isometric Shape Correspondence Using EM Algorithm  

E-print Network

Minimum-Distortion Isometric Shape Correspondence Using EM Algorithm Yusuf Sahillioglu and Yu¨cel Yemez Abstract--We present a purely isometric method that establishes 3D correspondence between two (nearly) isometric shapes. Our method evenly samples high-curvature vertices from the given mesh

Yemez, Yücel


ISSN 0103-9741 Monografias em Cincia da Computao  

E-print Network

into cells from all three germinal layers while multipotent stem cells can generate only closely relatedISSN 0103-9741 Monografias em Ciência da Computação n° 04/09 Automatic Embryonic Stem Cells de Lucena February, 2009 Automatic Embryonic Stem Cells Detection and Counting in Fluorescence

Endler, Markus



E-print Network

identificação, sendo Carteira de identidade e CPF (original e fotocópia, ou fotocópia autenticada em cartório de Botânica Campus Universitário ­ Trindade - Florianópolis-SC-Brasil Cx. Postal 476 - CEP 88040

Floeter, Sergio Ricardo


A Generalized Partial Credit Model: Application of an EM Algorithm  

Microsoft Academic Search

The partial credit model (PCM) with a varying slope parameter is developed and called the generalized partial credit model (GPCM). The item step parameter of this model is decomposed to a location and a threshold parameter, following Andrich's (1978) rating scale formulation. The EM algorithm for estimating the model parameters is derived. The performance of this generalized model is compared

Eiji Muraki



7 CFR 1945.20 - Making EM loans available.  

Code of Federal Regulations, 2010 CFR

...1945.20 Making EM loans...the actions required by § 1945...and other factors which are...Secretary in making determinations...Secretary in making a decision on the requested...consider other factors in accordance...the actions required in...



EM Ground-Wave Propagation over the Curved Lunar Surface  

Microsoft Academic Search

VLF and LF electromagnetic (EM) ground-wave propagation between points on the surface of a smooth lunar sphere which is surrounded by free space or a cold isotropic plasma is investigated. Following Ward's analysis of recent lunar geophysical data, two mathematical models which are most likely to actually exist were chosen as either a cold homogeneous moon or a hot wet

Se Hyun Cho; Ray King




Microsoft Academic Search

1. INTRODUÇÃO Desde os tempos de Alfred Marshall, a teoria econômica procura criar mo- delos que capturem a lógica do comportamento das firmas e dos merca- dos. Os resultados destes esforços não resultaram em um quadro analítico convergente, já que persistem controvérsias importantes acerca do papel das diferentes forças que influenciam o crescimento e os objetivos da firma. Winter (1993),

Paulo Bastos Tigre



Microsoft Academic Search

The traditional sequence of topics in the E&M portion of the calculus-based introductory physics poses serious conceptual problems for the student. New concepts are introduced extremely rapidly; abstractions are layered on top of abstractions; complex mathematical formalisms are introduced rapidly; and the student is expected to assimilate all of this quickly. To many students it is not even clear what

Ruth Chabay; Bruce Sherwood


An EM algorithm for wavelet-based image restoration  

Microsoft Academic Search

Abstract: This paper introduces an expectation--maximization(EM) algorithm for image restoration (deconvolution) based on apenalized likelihood formulated in the wavelet domain. Regularizationis achieved by promoting a reconstruction with low-complexity,expressed in the wavelet coefficients, taking advantage ofthe well known sparsity of wavelet representations. Previous workshave investigated wavelet-based restoration but, except for certainspecial cases, the resulting criteria are solved...

Mário A. T. Figueiredo; Robert D. Nowak




Microsoft Academic Search

RESUMO: Este artigo apresenta e reflete sobre a trajetória da disciplina lingüística Análise do Discurso, tomando por base para essa reflexão os conceitos de paradigma e de continuidade vs. descontinuidade históricas, postulados por Khun. Embora a Análise do Discurso tenha sido fundada na França na década de 60, com um propósito definido, seu contato com outros povos possibilitou alteração em

Eli Gomes Castanho; Jarbas Vargas Nascimento


NUMBER: EM 1.00 (NEW) SECTION: Emergency Management  

E-print Network

NUMBER: EM 1.00 (NEW) SECTION: Emergency Management SUBJECT: Emergency Notification System Policy and taking into account the safety of the community, activate the notification system, unless issuing the Carolina Alert system. a. Emergency Management Coordinator, University of South Carolina Division of Law

Almor, Amit


The EM Algorithm for Mixtures of Factor Analyzers Zoubin Ghahramani  

E-print Network

). The algorithm used by these authors for dimensionality reduction is principal components analysis (PCA). 1 #12;z components analyzers to a mixture of factor analyzers. Their learning algorithm consisted of an outer loop of approximate EM to t the mixture components, combined with an inner loop of gradient descent to t each

Ghahramani, Zoubin


Cost-Effectiveness Analysis of Helicopter EMS for Trauma Patients  

Microsoft Academic Search

Study objective: To evaluate the cost-effectiveness of helicopter EMS for trauma patients. Methods: We applied a cost-effectiveness analysis from the service provider's perspective to cost and effectiveness estimates. The cost estimates comprise direct operating costs and additional survivors' hospital costs. The effectiveness estimates were calculated with the TRISS methodology from literature sources and data from a cohort of patients transported

Peter A Gearhart; Richard Wuerz; A. Russell Localio




E-print Network

MESTRADO EM MICROBIOLOGIA FÁBRICAS CELULARES MICROBIANAS ­ Instituto Superior Técnico Objectivos: O microbiologia celular e molecular com as novas abordagens da engenharia metabólica à escala do genoma procariotas e eucariotas: - Estruturas celulares e compartimentalização; - Sistemas de transporte; - Fluxo de

Instituto de Sistemas e Robotica


Da Causalidade à Indecidibilidade em Ciências da Terra  

Microsoft Academic Search

As Ciências da Terra estudam a historia da Terra mas também os processos que aí ocorrem. São simultaneamente Ciências Históricas e Dinâmicas. O principio das causas actuais, enunciado por Lyell no século XIX, procurava explicar o passado a partir do presente e levou ao uniformismo, que suplantou o catastrofismo ainda no século XIX. Mas a observação dos processos em profundidade

A. Ribeiro


Hierarchical mixtures of experts and the EM algorithm  

Microsoft Academic Search

We present a tree-structured architecture for supervised learning. The statistical model underlying the architecture is a hierarchical mixture model in which both the mixture coefficients and the mixture components are generalized linear models (GLIMs). Learning is treated as a maximum likelihood problem; in particular, we present an expectation-maximization (EM) algorithm for adjusting the parameters of the architecture. We also develop

Michael I. Jordan; Robert A. Jacobs



Hierarchical Mixtures of Experts and the EM Algorithm  

Microsoft Academic Search

We present a tree-structured architecture for supervised learning. The statistical model underlying the architecture is a hierarchical mixture model in which both the mixture coefficients and the mixture components are generalized linear models (GLIM's). Learning is treated as a maximum likelihood problem; in particular, we present an Expectation-Maximization (EM) algorithm for adjusting the parameters of the architecture. We also develop

Michael I. Jordan; Robert A. Jacobs



ISSN 0103-9741 Monografias em Cincia da Computao  

E-print Network

, jogos para telefones celulares podem ser sé- rios candidatos a se tornarem uma forma importante de entretenimento em um futuro próximo. Entretanto, a maioria dos jogos (para computadores, consoles e dispositivos tipo de entretenimento. Embora jogos para telefones celulares pu- dessem atender a muitos usuários com

Endler, Markus



E-print Network

COMBINATION OF EM AND DC MEASUREMENTS FOR UPPER CRUSTAL STUDIES T. HARINARAYANA National method alone, could possibly be identified by a combination of methods. Further, distortion or error. This review covers the main results of the combination of these methods, giving more emphasis to case

Harinarayana, T.


População estelar nuclear e extranuclear em galáxias Seyfert 2  

NASA Astrophysics Data System (ADS)

A luz das estrelas foi, historicamente, vista por observadores de AGNs como uma poluição inconveniente. Conseqüentemente, a informação contida nas características estelares foi, durante muito tempo, largamente omitida. Nos primeiros estudos, o método empregado para remover esta contaminação estelar foi representá-la por um template de galáxia elíptica e subtraí-la do espectro observado, restando o puro AGN como um resíduo. Hoje sabemos que não é tão simples representar essa população. Vários estudos têm mostrado a presença de formação estelar recente próxima a região nuclear de galáxias Seyfert. Neste trabalho foi revisada a abordagem tradicional, tendo-se focalizado a análise na luz estelar. Espectros óticos de fenda longa, com alta razão sinal/ruído, foram usados para estudar a variação radial das larguras equivalentes de linhas de absorção e cores do contínuo. Utilizando o método de síntese espectral de populações estelares, foram estimadas as contribuições de populações estelares de diferentes idades (e de um contínuo tipo lei de potência) para a luz integrada das galáxias, em 4020A. As principais conclusões deste trabalho são: na região nuclear, mais da metade das galáxias Seyfert 2 da amostra (57%) apresenta contribuições das populações com 100 milhões de anos ou mais jovens superior a 20% do fluxo em 4020A, enquanto que em cerca de 40% delas a componente de 3 milhões de anos (e/ou luz que provem de um núcleo ativo) tem contribuição significativa (maior do que 10%). Estas contribuições em geral decrescem quando se vai para regiões mais distantes do centro das galáxias, respectivamente 53% e 30% a 1kpc, 40% e 15% a 3kpc do centro das galáxias. Estes resultados foram comparados com aqueles obtidos para uma amostra de galáxias não ativas de mesmo tipo de Hubble das Seyfert. Em uma análise inicial nota-se que em geral as galáxias Seyfert apresentam contribuições das populações de 100 milhões de anos maiores do que aquelas encontradas nas galáxias não ativas, sugerindo uma ligação entre a formação estelar e a atividade em galáxias.

Raimann, D. I.; Storchi-Bergmann, T.; Cid Fernandes, R., Jr.; Delgado, R. M. G.; Schmitt, H.; Heckman, T.; Leitherer, C.



Effective Teaching of Photonics E&M Theory Using COMSOL  

NSDL National Science Digital Library

Photonics and optical communications, after the exuberant growth and subsequent down turn in late 1990s and early 2000s, have entered a more mature and stable growth phase. As the technology of choice for long distance, high data rate, and high performance communication systems underlying the now ubiquitous Internet communications, photonics and optical communication professionals are and will continue to be in high demand. Because electromagnetic (E&M) theory is the foundation of photonics and optical communications, mastery of E&M theory is essential for those electrical engineering (EE) students who want to develop a career in this field. Traditionally, rigorous analytic skills in advanced mathematics especially in subjects such as partial differential equations (PDE) and linear algebra are a must to the understanding and applications of E&M theory, as well as photonic device and waveguide designs. However, as practical designs grow in complexity, even the most sophisticated and advanced analytic techniques in these mathematical subject areas can quickly fall short of being a suitable practical design tool. Standard industry practices utilize comprehensive software simulation packages to address these design needs. It is therefore appropriate and advantageous for EE students to learn and more importantly visualize the E&M theory by combining the basic mathematical principles, e.g., the Maxwell equations and wave equations, with practical software tools that they are more likely to use in their professional life. This paper discusses the introduction of COMSOL, a predominant industry PDE solver, to senior EE undergraduates as a learning tool of fundamental concepts in photonics such as transverse electrical (TE) modes and transverse magnetic (TM) modes in planar waveguide designs. This teaching method improves teaching effectiveness of E&M field and wave theory by helping the students better understand mathematical complexities through this readily available and reliable software tool. In addition to the theory, the students also gain the design capability using these industry standard software packages, and therefore bridging the gap between theory and practice.



ATTRACT-EM: A New Method for the Computational Assembly of Large Molecular Machines Using Cryo-EM Maps  

PubMed Central

Many of the most important functions in the cell are carried out by proteins organized in large molecular machines. Cryo-electron microscopy (cryo-EM) is increasingly being used to obtain low resolution density maps of these large assemblies. A new method, ATTRACT-EM, for the computational assembly of molecular assemblies from their components has been developed. Based on concepts from the protein-protein docking field, it utilizes cryo-EM density maps to assemble molecular subunits at near atomic detail, starting from millions of initial subunit configurations. The search efficiency was further enhanced by recombining partial solutions, the inclusion of symmetry information, and refinement using a molecular force field. The approach was tested on the GroES-GroEL system, using an experimental cryo-EM map at 23.5 Å resolution, and on several smaller complexes. Inclusion of experimental information on the symmetry of the systems and the application of a new gradient vector matching algorithm allowed the efficient identification of docked assemblies in close agreement with experiment. Application to the GroES-GroEL complex resulted in a top ranked model with a deviation of 4.6 Å (and a 2.8 Å model within the top 10) from the GroES-GroEL crystal structure, a significant improvement over existing methods. PMID:23251350

de Vries, Sjoerd J.; Zacharias, Martin



Application of Electromagnetic (EM) Separation Technology to Metal Refining Processes: A Review  

NASA Astrophysics Data System (ADS)

Application of electromagnetic (EM) force to metal processing has been considered as an emerging technology for the production of clean metals and other advanced materials. In the current paper, the principle of EM separation was introduced and several schemes of imposing EM field, such as DC electric field with a crossed steady magnetic field, AC electric field, AC magnetic field, and traveling magnetic field were reviewed. The force around a single particle or multi-particles and their trajectories in the conductive liquid under EM field were discussed. Applications of EM technique to the purification of different liquid metals such as aluminum, zinc, magnesium, silicon, copper, and steel were summarized. Effects of EM processing parameters, such as the frequency of imposed field, imposed magnetic flux density, processing time, particle size, and the EM unit size on the EM purification efficiency were discussed. Experimental and theoretical investigations have showed that the separation efficiency of inclusions from the molten aluminum using EM purification could as high as over 90 pct. Meanwhile, the EM purification was also applied to separate intermetallic compounds from metal melt, such as ?-AlFeMnSi-phase from the molten aluminum. And then the potential industrial application of EM technique was proposed.

Zhang, Lifeng; Wang, Shengqian; Dong, Anping; Gao, Jianwei; Damoah, Lucas Nana Wiredu



PAPEL DO EXERCÍCIO FÍSICO NA DISFUNÇÃO ENDOTELIAL DE PACIENTES COM SÍNDROME METABÓLICA E DIABETES MELLITUS The role of physical exercise in endothelial dysfunction of patients with Metabolic Syndrome and Diabetes Mellitus  

Microsoft Academic Search

RESUMO Pacientes com síndrome metabólica e diabetes mellitus têm morbidade e mortalidade cardiovascular aumentada. A disfunção endotelial tem sido implicada na patogênese da doença vascular diabética. Essa função anormal ocorre precocemente antes da manifestação da doença cardiovascular, caracterizando-se por redução do vasorelaxamento dependente do endotélio. Neste sentido, intervenções com a L-arginina, drogas de redução lipídicas (estatinas), antioxidantes (vitamina C) e

Carlos Alberto da Silva; José Carlos Grando


Magnetic field effects on endcap EM calorimetry in SDC  

SciTech Connect

The SDC calorimeter will be immersed in a strong magnetic field in the endcap region because of the solenoid which supplies the SDC tracking field. This flux must be returned through the endcap region of the electromagnetic (EM) and hadronic (HAD) calorimeters. Since magnetic fields are known to induce changes in the light output of plastic scintillator, the endcap will need to be recalibrated once the solenoid is energized. In addition, gradients in the field will create nonuniformities in the calorimetric response. The induced constant term'' in the EM and HAD calorimeters due to the inhomogeneities induced by the magnetic field are here evaluated in order to see that SDC performance specifications are not compromised.

Green, D.



Magnetic field effects on endcap EM calorimetry in SDC  

SciTech Connect

The SDC calorimeter will be immersed in a strong magnetic field in the endcap region because of the solenoid which supplies the SDC tracking field. This flux must be returned through the endcap region of the electromagnetic (EM) and hadronic (HAD) calorimeters. Since magnetic fields are known to induce changes in the light output of plastic scintillator, the endcap will need to be recalibrated once the solenoid is energized. In addition, gradients in the field will create nonuniformities in the calorimetric response. The ``induced constant term`` in the EM and HAD calorimeters due to the inhomogeneities induced by the magnetic field are here evaluated in order to see that SDC performance specifications are not compromised.

Green, D.



Da universidade para o mercado de trabalho em onze pases  

E-print Network

Universia está a ser lançado em várias instituições de ensino superior portuguesas. Rede ibero-americana regista por mês 195 mil ofertas ANA BELA FERREIRA Desde quinta-feira que os 23 mil alunos da Universidade a pró-rei- tora, Ana Nunes de Almeida. Ao aderir a esta plataforma, que con- centra não só ofertas

Instituto de Sistemas e Robotica


DustEM: Dust extinction and emission modelling  

NASA Astrophysics Data System (ADS)

DustEM computes the extinction and the emission of interstellar dust grains heated by photons. It is written in Fortran 95 and is jointly developed by IAS and CESR. The dust emission is calculated in the optically thin limit (no radiative transfer) and the default spectral range is 40 to 108 nm. The code is designed so dust properties can easily be changed and mixed and to allow for the inclusion of new grain physics.

Compiègne, M.; Verstraete, L.; Jones, A.; Bernard, J.-P.; Boulanger, F.; Flagey, N.; Le Bourlot, J.; Paradis, D.; Ysard, N.




E-print Network

MESTRADO EM MICROBIOLOGIA MICROBIOLOGIA DOS ALIMENTOS ­ Faculdade de Medicina Veterinária Objectivos: Esta UC visa ministrar formação geral e específica no domínio da Microbiologia dos Alimentos e que interfiram com a segurança sanitária dos alimentos ou promovam a respectiva fermentação, cura ou

Instituto de Sistemas e Robotica



E-print Network

candidatos residentes no Brasil. 3.4 Poderão inscrever-se no processo seletivo candidatos em fase de e Cópia do CPF. 3.5.7 Comprovante original do recolhimento da taxa de inscrição no valor de R$ 100,00 (cem reais) no Banco do Brasil (001), Agência 1607-1, conta 170500-8 (Conta �nica do Tesouro), código

Maier, Rudolf Richard


EMS mutagenesis in the pea aphid Acyrthosiphon pisum.  


In aphids, clonal individuals can show distinct morphologic traits in response to environmental cues. Such phenotypic plasticity cannot be studied with classical genetic model organisms such as Caenorhabditis elegans or Drosophila melanogaster. The genetic basis of this biological process remain unknown, as mutations affecting this process are not available in aphids. Here, we describe a protocol to treat third-stage larvae with an alkylating mutagen, ethyl methanesulfonate (EMS), to generate random mutations within the Acyrthosiphon pisum genome. We found that even low concentrations of EMS were toxic for two genotypes of A. pisum. Mutagenesis efficiency was nevertheless assessed by estimating the occurrence of mutational events on the X chromosome. Indeed, any lethal mutation on the X-chromosome would kill males that are haploid on the X so that we used the proportion of males as an estimation of mutagenesis efficacy. We could assess a putative mutation rate of 0.4 per X-chromosome at 10 mM of EMS. We then applied this protocol to perform a small-scale mutagenesis on parthenogenetic individuals, which were screened for defects in their ability to produce sexual individuals in response to photoperiod shortening. We found one mutant line showing a reproducible altered photoperiodic response with a reduced production of males and the appearance of aberrant winged males (wing atrophy, alteration of legs morphology). This mutation appeared to be stable because it could be transmitted over several generations of parthenogenetic individuals. To our knowledge, this study represents the first example of an EMS-generated aphid mutant. PMID:24531730

Tagu, Denis; Le Trionnaire, Gaël; Tanguy, Sylvie; Gauthier, Jean-Pierre; Huynh, Jean-René



Agentes e Emoes em Histrias Interativas Cesar Tadeu Pozzer  

E-print Network

foco da construção de elementos autônomos, semelhantes a personagens inteligentes de jogos eletrônicos entretenimento digital. Jogos de computador, que a cada dia estão mais avançados e que diariamente causam espanto). Diversas técnicas de IA são usadas em jogos para dar aos personagens características de aprendizado, tomada

Endler, Markus


A Biblioteca do IB em nmeros 2013 Acervo Total (publicaes)  

E-print Network

Total atual Livros * 347 33.796 Teses 259 3.483 Títulos de Periódicos 2.132 Correntes ** 256 Não livros e teses) Biblioteca fornecedora 262 Biblioteca solicitante 100 Nº de cópias fornecidas 3 a Biblioteca comprou 156 livros e recebeu em doação 36. ** 256 por compra, 65 por doação e 78 por permuta. #12;

Morandini, Andre C.


Plant's EMS yields 11-month payback in fuel savings  

SciTech Connect

A Johnson Controls 85 energy-management system (EMS) saved the King-Seeley Thermos Co. $70,000 in fuel costs and paid for itself within a year. The system controls 141 points in the 420,000-square-foot plant. Although the Johnson system was the low bidder, its software package with English language programming was the deciding factor. A summary of the JC 85 system describes its functions and performance. (DCK)

Galvin, C.




E-print Network

. Disciplinas do Núcleo obrigatório de Matemática Aplicada Matemática Computacional I Matemática Computacional Análise Wavelet I Análise Wavelet II Aprendizado Computacional e Reconhecimento de Padrões Banco de Dados Computacional e Aplicações Introdução à Teoria de Sistemas Dinâmicos Matemática Computacional III Métodos em


A Bayesian View on Cryo-EM Structure Determination  

PubMed Central

Three-dimensional (3D) structure determination by single-particle analysis of cryo-electron microscopy (cryo-EM) images requires many parameters to be determined from extremely noisy data. This makes the method prone to overfitting, that is, when structures describe noise rather than signal, in particular near their resolution limit where noise levels are highest. Cryo-EM structures are typically filtered using ad hoc procedures to prevent overfitting, but the tuning of arbitrary parameters may lead to subjectivity in the results. I describe a Bayesian interpretation of cryo-EM structure determination, where smoothness in the reconstructed density is imposed through a Gaussian prior in the Fourier domain. The statistical framework dictates how data and prior knowledge should be combined, so that the optimal 3D linear filter is obtained without the need for arbitrariness and objective resolution estimates may be obtained. Application to experimental data indicates that the statistical approach yields more reliable structures than existing methods and is capable of detecting smaller classes in data sets that contain multiple different structures. PMID:22100448

Scheres, Sjors H.W.



A study on characteristics of EM radiation from stripline structure  

NASA Astrophysics Data System (ADS)

In recent years, effective methods for predicting and suppressing electromagnetic interference over a broad band are required. In this paper, we focus on the prediction of electromagnetic (EM) radiation from a stripline structure with a ground thin wire by an equivalent circuit model. First, frequency responses of common-mode (CM) current on the printed circuit board and EM radiation are studied with finite difference time domain modeling. Secondly, an equivalent circuit model for predicting CM current is proposed. The equivalent circuit model for prediction is based on the concepts of CM antenna impedance, distributed constant circuit, and electric coupling between the power plane and the thin ground wire. Good agreement between the predicted and full-wave analysis results indicates the validity of the proposed equivalent circuit model. The frequency response of EM radiation from the stripline structure can be identified using our proposed model. In addition, the equivalent circuit model provides enough flexibility for different geometric parameters and can be used to develop physical insights and design guidelines.

Kayano, Yoshiki; Inoue, Hiroshi



The US DOE-EM International Program - 13004  

SciTech Connect

The U.S. Department of Energy (DOE) Office of Environmental Management (EM) conducts international collaboration activities in support of U.S. policies and objectives regarding the accelerated risk reduction and remediation of environmental legacy of the nations' nuclear weapons program and government sponsored nuclear energy research. The EM International Program supported out of the EM Office of the Associate Principal Deputy Assistant Secretary pursues collaborations with foreign government organizations, educational institutions and private industry to assist in identifying technologies and promote international collaborations that leverage resources and link international experience and expertise. In fiscal year (FY) 2012, the International Program awarded eight international collaborative projects for work scope spanning waste processing, groundwater and soil remediation, deactivation and decommissioning (D and D) and nuclear materials disposition initiatives to seven foreign organizations. Additionally, the International Program's scope and collaboration opportunities were expanded to include technical as well as non-technical areas. This paper will present an overview of the on-going tasks awarded in FY 2012 and an update of upcoming international activities and opportunities for expansion into FY 2013 and beyond. (authors)

Elmetti, Rosa R.; Han, Ana M.; Williams, Alice C. [Department of Energy, Office of Environmental Management, 1000 Independence Ave. SW, Washington, DC 20585 (United States)] [Department of Energy, Office of Environmental Management, 1000 Independence Ave. SW, Washington, DC 20585 (United States)



Covariance Matrix Estimation for the Cryo-EM Heterogeneity Problem  

E-print Network

In cryo-electron microscopy (cryo-EM), a microscope generates a top view of a sample of randomly-oriented copies of a molecule. The cryo-EM problem is to use the resulting set of noisy 2D projection images taken at unknown directions to reconstruct the 3D structure of the molecule. In some situations, the molecule under examination exhibits structural variability, which poses a fundamental challenge in cryo-EM. The heterogeneity problem is the task of mapping the space of conformational states of a molecule. It has been previously shown that the leading eigenvectors of the covariance matrix of the 3D molecules can be used to solve the heterogeneity problem. Estimating the covariance matrix is however challenging, since only projections of the molecules are observed, but not the molecules themselves. In this paper, we derive an estimator for the covariance matrix as a solution to a certain linear system. The linear operator to be inverted, which we term the tomographic covariance transform, is an important obj...

Katsevich, Gene; Singer, Amit




PubMed Central

Objetivo Realizar uma análise da inserção da ética e humanidades no currículo do Curso de Medicina da Escola Superior em Ciências da Saúde - ESCS, escola pública do Distrito Federal, Brasil, de forma a contribuir com o processo de gestão curricular. Metodologia O Estudo é de coorte e documental. Foram pesquisados 37 termos relacionados à ética e 36 referentes à humanização nos objetivos educacionais e conteúdo dos módulos temáticos, habilidades e atitudes e interação ensino-serviço-comunidade, de 1a a 4a série e no programa do internato no currículo (ano 2006) e no projeto pedagógico do Curso de Medicina (2001). Resultados Maior inserção da humanização, ética e bioética na 1a e 2a série, quando comparado à inserção na 3a e 4a série e no internato, (IC95%-?=0,034, pvalue=0,007). Unidade de habilidades e atitudes: freqüência das 3 temáticas no currículo da 1a a 4a séries (IC95%-?=0,026, pvalue=0,013). Quando comparada a inserção entre o internato e as quatro primeiras séries, observa-se que nestas a inserção da temática humanização é superior (IC95%-?=0,042, pvalue=0,029). Conclusão O currículo desenvolvido no ano de 2006 na ESCS apresentou correlação com o projeto pedagógico do curso e contemplou a temática de forma abrangente, em todas as séries e internato. PMID:20396594

Novaes, Maria Rita Carvalho Garbi; Novaes, Luiz Carlos Garcez; Guilhem, Dirce; Lolas, Fernando; Silveira, Carla; Guiotti, Murilo



EMS-STARS: Emergency Medical Services "Superuser" Transport Associations: An Adult Retrospective Study.  


Abstract Objective. Emergency medical services (EMS) "superusers" -those who use EMS services at extremely high rates -have not been well characterized. Recent interest in the small group of individuals who account for a disproportionate share of health-care expenditures has led to research on frequent users of emergency departments and other health services, but little research has been done regarding those who use EMS services. To inform policy and intervention implementation, we undertook a descriptive analysis of EMS superusers in a large urban community. In this paper we compare EMS superusers to low, moderate, and high users to characterize factors contributing to EMS use. We also estimate the financial impact of EMS superusers. Methods. We conducted a retrospective cross-sectional study based on 1 year of data from an urban EMS system. Data for all EMS encounters with patients age ?18 years were extracted from electronic records generated on scene by paramedics. We identified demographic and clinical variables associated with levels of EMS use. EMS users were characterized by the annual number of EMS encounters: low (1), moderate (2-4), high (5-14), and superusers (?15). In addition, we performed a financial analysis using San Francisco Fire Department (SFFD) 2009 charge and reimbursement data. Results. A total of 31,462 adults generated 43,559 EMS ambulance encounters, which resulted in 39,107 transports (a 90% transport rate). Encounters for general medical reasons were common among moderate and high users and less frequent among superusers and low users, while alcohol use was exponentially correlated with encounter frequency. Superusers were significantly younger than moderate EMS users, and more likely to be male. The superuser group created a significantly higher financial burden/person than any other group, comprising 0.3% of the study population, but over 6% of annual EMS charges and reimbursements. Conclusions. In this retrospective study, adult EMS "superusers" emerged as a distinct, predominantly male population and their EMS encounters were associated with alcohol use. Continued analysis of this unique, high-cost, and frequently transported population will likely illuminate specific intervention strategies. PMID:25093273

Hall, M Kennedy; Raven, Maria C; Hall, Jane; Yeh, Clement; Allen, Elaine; Rodriguez, Robert M; Tangherlini, Niels L; Sporer, Karl A; Brown, John F



Programa de Ps-Graduao em Cincia dos Alimentos CAL/CCA/UFSC Regimento Interno  

E-print Network


Floeter, Sergio Ricardo


iGrace modle informatique d'motions du robot compagnon EmI  

E-print Network

1 iGrace ­ modèle informatique d'émotions du robot compagnon EmI iGrace ­ emotional computational model for EmI companion robot Sébastien SAINT-AIM�, Brigitte LE-P�V�DIC, Dominique DUHAUT Valoria of EmI, as well as improvements to be made for its third version. Keywords. Emotions, computational

Paris-Sud XI, Université de


Quantificação de nitrofurazona e de nitrofurantoína em medicamentos por espectrofotometria de refletância difusa e de transmissão.  

E-print Network

??A nitrofurazona e a nitrofurantoína são substâncias derivadas dos nitrofuranos e comercializadas em preparações farmacêuticas com ação bactericida, antifúngica e antimicrobiana com um amplo espectro… (more)

Marcio das Neves Palumbo



Avaliação da infecção por morbilivírus em cetáceos arrojados na costa portuguesa.  

E-print Network

??Dissertação de Mestrado Integrado em Medicina Veterinária O Dolphin morbilivírus (DMV) e o Porpoise morbillivirus (PMV) são membros da subfamília Paramyxovirinae, família Paramyxoviridae. Estes vírus… (more)

Bento, Maria Carolina Rocha de Medeiros



Modeling of MHD edge containment in strip casting with ELEKTRA and CaPS-EM codes  

SciTech Connect

This paper presents modeling studies of magnetohydrodynamics analysis in twin-roll casting. Argonne National Laboratory (ANL) and ISPAT Inland Inc. (Inland), formerly Inland Steel Co., have worked together to develop a three-dimensional (3-D) computer model that can predict eddy currents, fluid flows, and liquid metal containment of an electromagnetic (EM) edge containment device. The model was verified by comparing predictions with experimental results of liquid metal containment and fluid flow in EM edge dams (EMDs) that were designed at Inland for twin-roll casting. This mathematical model can significantly shorten casting research on the use of EM fields for liquid metal containment and control. The model can optimize the EMD design so it is suitable for application, and minimize expensive time-consuming full-scale testing. Numerical simulation was performed by coupling a 3-D finite-element EM code (ELEKTRA) and a 3-D finite-difference fluids code (CaPS-EM) to solve heat transfer, fluid flow, and turbulence transport in a casting process that involves EM fields. ELEKTRA can predict the eddy-current distribution and the EM forces in complex geometries. CaPS-EM can model fluid flows with free surfaces. The computed 3-D magnetic fields and induced eddy currents in ELEKTRA are used as input to temperature- and flow-field computations in CaPS-EM. Results of the numerical simulation compared well with measurements obtained from both static and dynamic tests.

Chang, F. C.



Iniciativas de Transição e Permacultura, como reestruturação e capacitação de comunidades em Portugal.  

E-print Network

??Mestrado em Gestão e Estratégia Industrial Este trabalho visa abordar o movimento de Iniciativas de Transição, analisando as suas motivações, baseadas fundamentalmente na insustentabilidade da… (more)

Soares, Pedro David Almeida Rebelo



Covariance Matrix Estimation for the Cryo-EM Heterogeneity Problem*  

PubMed Central

In cryo-electron microscopy (cryo-EM), a microscope generates a top view of a sample of randomly oriented copies of a molecule. The problem of single particle reconstruction (SPR) from cryo-EM is to use the resulting set of noisy two-dimensional projection images taken at unknown directions to reconstruct the three-dimensional (3D) structure of the molecule. In some situations, the molecule under examination exhibits structural variability, which poses a fundamental challenge in SPR. The heterogeneity problem is the task of mapping the space of conformational states of a molecule. It has been previously suggested that the leading eigenvectors of the covariance matrix of the 3D molecules can be used to solve the heterogeneity problem. Estimating the covariance matrix is challenging, since only projections of the molecules are observed, but not the molecules themselves. In this paper, we formulate a general problem of covariance estimation from noisy projections of samples. This problem has intimate connections with matrix completion problems and high-dimensional principal component analysis. We propose an estimator and prove its consistency. When there are finitely many heterogeneity classes, the spectrum of the estimated covariance matrix reveals the number of classes. The estimator can be found as the solution to a certain linear system. In the cryo-EM case, the linear operator to be inverted, which we term the projection covariance transform, is an important object in covariance estimation for tomographic problems involving structural variation. Inverting it involves applying a filter akin to the ramp filter in tomography. We design a basis in which this linear operator is sparse and thus can be tractably inverted despite its large size. We demonstrate via numerical experiments on synthetic datasets the robustness of our algorithm to high levels of noise.

Katsevich, E.; Katsevich, A.; Singer, A.



This is the author's version of a work that was submitted/accepted for pub-lication in the following source  

E-print Network

for potential drug bioavailability compromise. Methods. Release and dissolution of crushed amlodipine, atenolol for their effect on the dissolution of crushed atenolol tablets. Results. Atenolol dissolution was unaffected medications with thickened water caused a significant delay in dissolution. When tested with atenolol, all

Boyd, Colin



E-print Network

Filosofia: 0,5 (um) ponto (até 1 pontos) 2.3. Livro de Filosofia: 1 (dois) pontos (até 2 pontos) 2.4. Resumo evento de Filosofia: 0,5 (um) ponto (até 1 pontos)" Leia-se "2.2. Capítulo de livro de Filosofia: 0,5 (meio) ponto (até 1 pontos) 2.3. Livro de Filosofia: 1 (um) ponto (até 2 pontos) 2.4. Resumo em anais de

Lucero, Jorge Carlos



E-print Network a partir de 12 de março de 2013); b) Cópia da Carteira de Identidade e do CPF; c) Cópia do DIPLOMA e do (apenas o CPF identificará o candidato), contendo `folha de rosto' (disponível a partir de 12 de março na, 1993. v. 2. p. 193-274. GONDRA, J. G. (Org.). Pesquisa em história da educação no Brasil. Rio de

Floeter, Sergio Ricardo


State of the Art in EM Field Computation  

SciTech Connect

This paper presents the advances in electromagnetic (EM) field computation that have been enabled by the US DOE SciDAC Accelerator Science and Technology project which supports the development and application of a suite of electromagnetic codes based on the higher-order finite element method. Implemented on distributed memory supercomputers, this state of the art simulation capability has produced results which are of great interest to accelerator designers and with realism previously not possible with standard codes. Examples from work on the International Linear Collider (ILC) project are described.

Ng, C.; Akcelik, V.; Candel, A.; Chen, S.; Folwell, N.; Ge, L.; Guetz, A.; Jiang, H.; Kabel, A.; Lee, L.-Q.; Li, Z.; Prudencio, E.; Schussman, G.; Uplenchwar, R.; Xiao,; Ko, K.; /SLAC



An Effective EMS Hardware and Software Interface- The Trained Operator  

E-print Network

print out a specific alarm message if a piece of equipment fails to operate properly. This knowledge merely enables the operator to list capabilities, it does not imply understanding of how to react to, alter or cause those events. Knowledge alone... to be productive and the owner can begin to realize EMS benefits. ANALYSIS ,..... The three skill levels achieved so far, should be regarded as the minimum necessary for acceptable system opera tion. The next two training levels rep resent "money in the bank...

Cherry, C. L.


SEI: Junior E&M I Course Materials - Electrodynamics  

NSDL National Science Digital Library

This is a collection of resources for teaching electrodynamics. Included are homework questions, concept tests, student tutorials, and information about common student difficulties in the topic and ways to address these difficulties. This material was developed as part of a education research-based course transformation for junior level E&M. All of the resources developed for this course are available, sorted by individual topic and type, at Because this topic is not typically taught in depth in the courses used in developing these course materials, these materials are less complete than the other sections.

Pollock, Steven J.; Chasteen, Stephanie V.



9/7/2004 Penumadu, Prashant, and Frost. EM-2004 1 A VIRTUAL TRIAXIAL COMPRESSION  

E-print Network

9/7/2004 Penumadu, Prashant, and Frost. EM-2004 1 A VIRTUAL TRIAXIAL COMPRESSION TEST SIMULATOR, Knoxville, TN, USA David J. Frost: Department of Civil and Environmental Engineering, Georgia Institute. #12;9/7/2004 Penumadu, Prashant, and Frost. EM-2004 2 Presentation Outline Concept of Virtual

Prashant, Amit


Global Convergence of the EM Algorithm for Unconstrained Latent Variable Models with Categorical Indicators  

ERIC Educational Resources Information Center

Convergence of the expectation-maximization (EM) algorithm to a global optimum of the marginal log likelihood function for unconstrained latent variable models with categorical indicators is presented. The sufficient conditions under which global convergence of the EM algorithm is attainable are provided in an information-theoretic context by…

Weissman, Alexander




Microsoft Academic Search

RESUMO Os eixos, quando transmitem torque, agem como molas torcionais, além da flexão. Quando há variação cíclica no torque transmitido podem aparecer vibrações torcionais forçadas, que dependendo das freqüências naturais do sistema poderão causar ressonância, caso em que o eixo poderá oscilar em amplitudes suficientemente elevadas para produzir falhas. O presente trabalho apresenta técnicas de medição e análise de vibração

Evaldo Khater


Comportamento de Pantala flavescens (Odonata, Anisoptera, Libellulidae) e perda do investimento reprodutivo em áreas antropizadas  

Microsoft Academic Search

RESUMO: Pantala flavescens é uma libélula exofítica, territorialista e migratória. Devido ao comportamento migratório, a ocorrência desta espécie em áreas não alagadas é comum. No entanto, a presença de P. flavescens em áreas de estacionamento de veículos e o registro de eventos de oviposição sobre as latarias de automóveis não é bem entendida. O presente trabalho apresenta dados comportamentais de

Antonia Figueira Van de Koken



Effectiveness of electromagnetic wave absorbers to improve 5.8 GHz DSRC EM environment inside tunnel  

Microsoft Academic Search

Electromagnetic (EM) wave absorbers have been used to improve the EM environment of an electronic toll collection (ETC) system on an express highway or a wireless local area network (LAN) system in an indoor environment. In this paper, an efficient multi-ray propagation model, which uses a combination of image technique and grid approach to trace multiple signal rays from transmitter




Developing State and National Evaluation Infrastructures- Guidance for the Challenges and Opportunities of EM&V  

SciTech Connect

Evaluating the impacts and effectiveness of energy efficiency programs is likely to become increasingly important for state policymakers and program administrators given legislative mandates and regulatory goals and increasing reliance on energy efficiency as a resource. In this paper, we summarize three activities that the authors have conducted that highlight the expanded role of evaluation, measurement and verification (EM&V): a study that identified and analyzed challenges in improving and scaling up EM&V activities; a scoping study that identified issues involved in developing a national efficiency EM&V standard; and lessons learned from providing technical assistance on EM&V issues to states that are ramping up energy efficiency programs. The lessons learned are summarized in 13 EM&V issues that policy makers should address in each jurisdiction and which are listed and briefly described. The paper also discusses how improving the effectiveness and reliability of EM&V will require additional capacity building, better access to existing EM&V resources, new methods to address emerging issues and technologies, and perhaps foundational documents and approaches to improving the credibility and cross jurisdictional comparability of efficiency investments. Two of the potential foundational documents discussed are a national EM&V standard or resource guide and regional deemed savings and algorithm databases.

Schiller, Steven R.; Goldman, Charles A.




E-print Network

COLOR IMAGE SEGMENTATION USING A SELF-INITIALIZING EM ALGORITHM Dana Elena Ilea and Paul F. Whelan-Maximization (EM) algorithm that we apply for color image segmentation. Since this algorithm partitions the data included in the development of an adaptive image segmentation scheme that has been applied to a large

Whelan, Paul F.


Adaptac~ao ao Contexto em Sistemas de Comunicac~ao Heterogeneos  

E-print Network

. Considerem-se por exemplo aplicac¸ ~oes cooperativas multi-utilizador tais como os jogos em rede ou aplicac¸~oes cooperativas multi-utilizador (tais como os jogos on-line). Embora a maioria das concretizac¸~oes actuais destes jogos se baseiem em arquitecturas cliente-servidor, foram j´a de- Este trabalho foi

Rodrigues, Luís E.T.


Uma Estratégia para a Visualização do Céu e seus Elementos em Jogos  

Microsoft Academic Search

Resumo Uma visualização convincente do céu e seus elementos (nuvens, sol, lua, estrelas) é fundamental para agregar realismo aos jogos que usam cenários em ambientes externos. Como uma simulação precisa desses efeitos pode ser computacionalmente muito cara, muitos jogos empregam artifícios, visualizando o céu como texturas mapeadas em esferas e caixas envolventes. Neste trabalho, apresentamos uma estratégia simples para simular



Method for evaluating compatibility of commercial electromagnetic (EM) microsensor tracking systems with surgical and imaging tables  

NASA Astrophysics Data System (ADS)

Electromagnetic (EM) tracking systems have been successfully used for Surgical Navigation in ENT, cranial, and spine applications for several years. Catheter sized micro EM sensors have also been used in tightly controlled cardiac mapping and pulmonary applications. EM systems have the benefit over optical navigation systems of not requiring a line-of-sight between devices. Ferrous metals or conductive materials that are transient within the EM working volume may impact tracking performance. Effective methods for detecting and reporting EM field distortions are generally well known. Distortion compensation can be achieved for objects that have a static spatial relationship to a tracking sensor. New commercially available micro EM tracking systems offer opportunities for expanded image-guided navigation procedures. It is important to know and understand how well these systems perform with different surgical tables and ancillary equipment. By their design and intended use, micro EM sensors will be located at the distal tip of tracked devices and therefore be in closer proximity to the tables. Our goal was to define a simple and portable process that could be used to estimate the EM tracker accuracy, and to vet a large number of popular general surgery and imaging tables that are used in the United States and abroad.

Nafis, Christopher; Jensen, Vern; von Jako, Ron



Chapter 19: HVAC Controls (DDC/EMS/BAS) Evaluation Protocol  

SciTech Connect

The HVAC Controls Evaluation Protocol is designed to address evaluation issues for direct digital controls/energy management systems/building automation systems (DDC/EMS/BAS) that are installed to control heating, ventilation, and air-conditioning (HVAC) equipment in commercial and institutional buildings. (This chapter refers to the DDC/EMS/BAS measure as HVAC controls.) This protocol may also be applicable to industrial facilities such as clean rooms and labs, which have either significant HVAC equipment or spaces requiring special environmental conditions. This protocol addresses only HVAC-related equipment and the energy savings estimation methods associated with installing such control systems as an energy efficiency measure. The affected equipment includes: Air-side equipment (air handlers, direct expansion systems, furnaces, other heating- and cooling-related devices, terminal air distribution equipment, and fans); Central plant equipment (chillers, cooling towers, boilers, and pumps). These controls may also operate or affect other end uses, such as lighting, domestic hot water, irrigation systems, and life safety systems such as fire alarms and other security systems. Considerable nonenergy benefits, such as maintenance scheduling, system component troubleshooting, equipment failure alarms, and increased equipment lifetime, may also be associated with these systems. When connected to building utility meters, these systems can also be valuable demand-limiting control tools. However, this protocol does not evaluate any of these additional capabilities and benefits.

Romberger, J.



Children recognize emotions of EmI companion robot Sebastien Saint-Aime and Brigitte Le Pevedic and Dominique Duhaut  

E-print Network

Children recognize emotions of EmI companion robot S´ebastien Saint-Aim´e and Brigitte Le P´ev´edic and Dominique Duhaut Abstract-- This article presents the evaluation of the emotio- nal expressiveness of EmI and implementation of EmI, and experimentation to evaluate the expressiveness of EmI with 52 school children aged 7

Paris-Sud XI, Université de


Prevalence of Depression and Cognitive Impairment in Older Adult EMS Patients  

PubMed Central

Objectives To characterize the proportion of older adult ED patients with depression or cognitive impairment. To compare the prevalence of depression or cognitive impairment among ED patients arriving via EMS, as compared to other modes. Methods Community-dwelling older adults (age?60) presenting to an academic medical center ED were interviewed. Participants provided demographic and clinical information, and were evaluated for depression and cognitive impairment. Subjects arriving via EMS were compared to those arriving via other modes using the chi-square test, t-test, and the Wilcoxon rank sum test, where appropriate. Results Consent was obtained from 1342 eligible older adults; 695 (52%) arrived via EMS. The median age for those arriving via EMS was 74 (IQR 65, 82), 52% were female, 81% white. 15% of EMS patients had moderate or greater depression, as compared to 14% of patients arriving via other modes (p=0.52). 13% of EMS patients had cognitive impairment, as compared to 8% arriving via other modes (p<0.01). Depressed EMS patients frequently reported a history of depression (47%) and taking antidepressants (51%). Cognitively impaired EMS patients infrequently reported a history of dementia (16%) or taking medications for dementia (14%). Conclusions In this cohort of community-dwelling older adult ED patients depression and cognitive impairment were common. As compared to ED patients arriving by other transport means, patients arriving via EMS had similar prevalence of depression but an increased prevalence of cognitive impairment. Screening for depression and cognitive impairment by EMS providers may have value, but needs further investigation. PMID:20977363

Shah, Manish N.; Jones, Courtney M. C.; Richardson, Thomas M.; Conwell, Yeates; Katz, Paul; Schneider, Sandra M.



The EM SSAB Annual Work Plan Process: Focusing Board Efforts and Resources - 13667  

SciTech Connect

One of the most daunting tasks for any new member of a local board of the Environmental Management Site Specific Advisory Board (EM SSAB) is to try to understand the scope of the clean-up activities going on at the site. In most cases, there are at least two or three major cleanup activities in progress as well as monitoring of past projects. When planning for future projects is added to the mix, the list of projects can be long. With the clean-up activities involving all major environmental media - air, water, soils, and groundwater, new EM SSAB members can find themselves totally overwhelmed and ineffective. Helping new members get over this initial hurdle is a major objective of EM and all local boards of the EM SSAB. Even as members start to understand the size and scope of the projects at a site, they can still be frustrated at the length of time it takes to see results and get projects completed. Many project and clean-up timelines for most of the sites go beyond 10 years, so it's not unusual for an EM SSAB member to see the completion of only 1 or 2 projects over the course of their 6-year term on the board. This paper explores the annual work planning process of the EM SSAB local boards, one tool that can be used to educate EM SSAB members into seeing the broader picture for the site. EM SSAB local work plans divide the site into projects focused on a specific environmental issue or media such as groundwater and/or waste disposal options. Projects are further broken down into smaller segments by highlighting major milestones. Using these metrics, local boards of the EM SSAB can start to quantify the effectiveness of the project in achieving the ultimate goal of site clean-up. These metrics can also trigger board advice and recommendations for EM. At the beginning of each fiscal year, the EM SSAB work plan provides a road map with quantifiable checkpoints for activities throughout the year. When the work plans are integrated with site-specific, enforceable regulatory milestones, they can provide a comprehensive work plan for not only the board, but also regulators, site contractors, and DOE. Because the work plans are reviewed and approved by DOE, they carry some weight in holding local boards of the EM SSAB accountable. This structure provides the basis for local boards to achieve their primary function, to provide DOE with information, advice, and recommendations concerning issues affecting the EM program at the site. (authors)

Young, Ralph [Paducah Citizens Advisory Board (United States)] [Paducah Citizens Advisory Board (United States)



Capturing RNA-dependent pathways for cryo-EM analysis  

PubMed Central

Cryo-Electron Microscopy (EM) is a powerful technique to visualize biological processes at nanometer resolution. Structural studies of macromolecular assemblies are typically performed on individual complexes that are biochemically isolated from their cellular context. Here we present a molecular imaging platform to capture and view multiple components of cellular pathways within a functionally relevant framework. We utilized the bacterial protein synthesis machinery as a model system to develop our approach. By using modified Affinity Grid surfaces, we were able to recruit multiple protein assemblies bound to nascent strands of mRNA. The combined use of Affinity Capture technology and single particle electron microscopy provide the basis for visualizing RNA-dependent pathways in a remarkable new way. PMID:24688633

Tanner, Justin R.; Degen, Katherine; Gilmore, Brian L.; Kelly, Deborah F.



High-dimensional cluster analysis with the Masked EM Algorithm  

PubMed Central

Cluster analysis faces two problems in high dimensions: first, the “curse of dimensionality” that can lead to overfitting and poor generalization performance; and second, the sheer time taken for conventional algorithms to process large amounts of high-dimensional data. We describe a solution to these problems, designed for the application of “spike sorting” for next-generation high channel-count neural probes. In this problem, only a small subset of features provide information about the cluster member-ship of any one data vector, but this informative feature subset is not the same for all data points, rendering classical feature selection ineffective. We introduce a “Masked EM” algorithm that allows accurate and time-efficient clustering of up to millions of points in thousands of dimensions. We demonstrate its applicability to synthetic data, and to real-world high-channel-count spike sorting data. PMID:25149694

Kadir, Shabnam N.; Goodman, Dan F. M.; Harris, Kenneth D.



SEI: Junior E&M I Course Materials - Homework  

NSDL National Science Digital Library

This homework question collection was constructed over the course of four semesters of a transformed junior-level Electricity and Magnetism course on electro- and magneto-statics. Many questions are related to textbook problems, but with added elements of explanation, sense-making, estimation or approximation, real-world connections, and multiple-representations. Not all these homework questions were used in the course design project. Some problems used include detailed instructor notes, including statistics on student performance on each homework problem assigned. The homework solutions are only available to instructors by writing the authors, This material was developed as part of a education research-based course transformation for junior level E&M. All of the resources developed for this course are available, sorted by individual topic and type, at

Pollock, Steven J.; Chasteen, Stephanie V.



EM Properties of Magnetic Minerals at RADAR Frequencies  

NASA Technical Reports Server (NTRS)

Previous missions to Mars have revealed that Mars surface is magnetic at DC frequency. Does this highly magnetic surface layer attenuate RADAR energy as it does in certain locations on Earth? It has been suggested that the active magnetic mineral on Mars is titanomaghemite and/or titanomagnetite. When titanium is incorporated into a maghemite or magnetite crystal, the Curie temperature can be significantly reduced. Mars has a wide range of daily temperature fluctuations (303K - 143K), which could allow for daily passes through the Curie temperature. Hence, the global dust layer on Mars could experience widely varying magnetic properties as a function of temperature, more specifically being ferromagnetic at night and paramagnetic during the day. Measurements of EM properties of magnetic minerals were made versus frequency and temperature (300K- 180K). Magnetic minerals and Martian analog samples were gathered from a number of different locations on Earth.

Stillman, D. E.; Olhoeft, G. R.



In-house labor saves University 50% of EMS cost  

SciTech Connect

By designing and installing its own energy-management system (EMS), the staff at Oklahoma State University hopes to reduce the cost of a Staefa EMA II system in half. However, the school has held up payment in accordance with its contract until some equipment problems are solved and the system is operating for 30 consecutive days at 95% of performance specifications. Faulty field multiplexers and inadequate voice-intercom equipment failed the first two acceptance tests. The 750-point system that will control 10 buildings should have a three-year payback. In-house crews are reducing installation costs because they are familiar with the buildings and can work around class schedules. Two separate bids were required because most bids failed to meet equipment specifications. (DCK)

Crawford, E.



SEI: Junior E&M I Course Materials - Tutorials  

NSDL National Science Digital Library

This collection of tutorials and tutorial pre-tests was constructed for a transformed junior-level Electricity and Magnetism course. These tutorials are weekly student sessions, modeled after research-validated curricula developed at the University of Washington. Using these materials in study/recitation sections, students work in small groups with the instructor as a learning coach. The materials are designed to target known student difficulties, to elicit and develop conceptual understanding and math/physics connections. They also help faculty listen to student reasoning, get a clearer sense of student ideas, and determine where they are struggling. This material was developed as part of a education research-based course transformation for junior level E&M. All of the resources developed for this course are available, sorted by individual topic and type, at

Pollock, Steven J.; Chasteen, Stephanie V.; Kinney, Edward; Dubson, Michael



Integrated EM & Thermal Simulations with Upgraded VORPAL Software  

SciTech Connect

Nuclear physics accelerators are powered by microwaves which must travel in waveguides between room-temperature sources and the cryogenic accelerator structures. The ohmic heat load from the microwaves is affected by the temperature-dependent surface resistance and in turn affects the cryogenic thermal conduction problem. Integrated EM & thermal analysis of this difficult non-linear problem is now possible with the VORPAL finite-difference time-domain simulation tool. We highlight thermal benchmarking work with a complex HOM feed-through geometry, done in collaboration with researchers at the Thomas Jefferson National Accelerator Laboratory, and discuss upcoming design studies with this emerging tool. This work is part of an effort to generalize the VORPAL framework to include generalized PDE capabilities, for wider multi-physics capabilities in the accelerator, vacuum electronics, plasma processing and fusion R&D fields, and we will also discuss user interface and algorithmic upgrades which facilitate this emerging multiphysics capability.

D.N. Smithe, D. Karipides, P. Stoltz, G. Cheng, H. Wang



EMS mutant spectra generated by multi-parameter flow cytometry.  


The CHO A(L) cell line contains a single copy of human chromosome 11 that encodes several cell surface proteins including glycosyl phosphatidylinositol (GPI) linked CD59 and CD90, as well as CD98, CD44 and CD151 which are not GPI-linked. The flow cytometry mutation assay (FCMA) measures mutations of the CD59 gene by the absence of fluorescence when stained with antibodies against the CD59 cell surface protein. We have measured simultaneous mutations in CD59, CD44, CD90, CD98 and CD151 to generate a mutant spectrum for ionizing radiation. After treatment with ethyl methanesulfonate (EMS) many cells have an intermediate level of CD59 staining. Single cells were sorted from CD59(-) regions with varying levels of fluorescence and the resulting clonal populations had a stable phenotype for CD59 expression. Mutant spectra were generated by flow cytometry using the isolated clones and nearly all clones were mutated in CD59 only. Interestingly, about 60% of the CD59 negative clones were actually GPI mutants determined by staining with the GPI specific fluorescently labeled bacterial toxin aerolysin (FLAER). The GPI negative cells are most likely caused by mutations in the X-linked pigA gene important in GPI biosynthesis. Small mutations of pigA and CD59 were expected for the alkylating agent EMS and the resulting spectra are significantly different than the large deletions found when analyzing radiation mutants. After analyzing the CD59(-) clonal populations we have adjusted the FCMA mutant regions from 1% to 10% of the mean of the CD59 positive peak to include the majority of CD59 mutants. PMID:19463836

Keysar, Stephen B; Fox, Michael H



Effects of integrated use of organic and inorganic nutrient sources with effective microorganisms (EM) on seed cotton yield in Pakistan.  


A field experiment was conducted to determine the effects of integrated use of organic and inorganic nutrient sources with effective microorganisms on growth and yield of cotton. Treatments included: control; organic materials (OM); effective microorganisms (EM); OM+EM; mineral NPK (170:85:60 kg); 1/2 mineral NPK+EM; 1/2 mineral NPK+OM+EM and mineral NPK+OM+EM. OM and EM alone did not increase the yield and yield attributing components significantly but integrated use of both resulted in a 44% increase over control. Application of NPK in combination with OM and EM resulted in the highest seed cotton yield (2470 kg ha-1). Integrated use of OM+EM with 1/2 mineral NPK yielded 2091 kg ha-1, similar to the yield (2165 kg ha-1) obtained from full recommended NPK, indicating that this combination can substitute for 85 kg N ha-1. Combination of both N sources with EM also increased the concentrations of NPK in plants. Economic analysis suggested the use of 1/2 mineral NPK with EM+OM saves the mineral N fertilizer by almost 50% compared to a system with only mineral NPK application. This study indicated that application of EM increased the efficiency of both organic and mineral nutrient sources but alone was ineffective in increasing yield. PMID:16023343

Khaliq, Abdul; Abbasi, M Kaleem; Hussain, Tahir



Effects of caffeine or EDTA post-treatment on EMS mutagenesis in soybean  

Microsoft Academic Search

Seeds of soybean cultivar LD4 were mutagenically treated with EMS (0.3, 0.5, 0.6, 0.9, 0.5 and 1.8%) for 3 h only or plus caffeine (50 mM) or EDTA (1 mM) post-treatment for 5 h. The experimental results indicated that: (1) of the different concentrations of EMS treatment, the M2 mutation frequency induced with 0.6% EMS was the highest (9.7%). When

Zhu Baoge; Gu Aiqiu; Deng Xiangdong; Deng Yuxuan; Lu Zixian



Um Framework para Proviso de QoS em Redes Mveis Sem Fio1  

E-print Network

Um Framework para Provisão de QoS em Redes Móveis Sem Fio1 Luciana dos Santos Lima, Antônio Tadeu A provisão de QoS em redes móveis sem fio integrando soluções isoladas encontradas na literatura. Esses descrita através de um cenário simulado em que serviços integrados são oferecidos sobre uma rede IP Móvel

Colcher, Sérgio


Centro de Cincias Agrrias Coordenao do Curso de Graduao em Cincia e Tecnologia de Alimentos  

E-print Network

Centro de Ciências Agrárias Coordenação do Curso de Graduação em Ciência e Tecnologia de Alimentos-2728 Regimento Interno do Curso de Graduação em Ciência e Tecnologia de alimentos Capítulo I ­ Das disposições iniciais Art. 1º - O Curso de Graduação em Ciência e Tecnologia de Alimentos, instituído pela Resolução 005

Floeter, Sergio Ricardo


User's guide for the PWR LOCA analysis capability of the WRAP-EM system  

SciTech Connect

The Water Reactor Analysis Package (WRAP) has been expanded to provide the capability to analyze loss-of-coolant accidents (LOCAs) in both pressurized water reactors (PWRs) and boiling water reactors (BWRs) by using evaluation models (EMs). The input specifications for modules in the WRAP-EM system are presented in this document along with the JOSHUA input templates. This document, along with the WRAP user's guide, provides a step-by-step procedure for setting up a PWR data base for the WRAP-EM system. 12 refs.

Beranek, F; Gregory, M V



UFF/PROGEPE/CASQ/DPVS Diviso de Promoo e Vigilncia em Sade-DPVS  

E-print Network

considerado uma das principais causas de morte evitável. No mundo, cerca de 1,3 bilhões de pessoas são considerado como a terceira maior causa de morte evitável aumentando a morbidade em crianças por doenças respiratórias e em cinco vezes o risco de morte súbita em bebês. A atual Portaria Nº 3 de 25 de março de 2013 da

Souza, Max O.


Investigating the source of contaminated plumes downstream of the Alborz Sharghi coal washing plant using EM34 conductivity data, VLF-EM and DC-resistivity geophysical methods  

NASA Astrophysics Data System (ADS)

Coal washing factories may create serious environmental problems due to pyrite oxidation and acid mine drainage generation from coal waste piles on nearby land. Infiltration of pyrite oxidation products through the porous materials of the coal waste pile by rainwater cause changes in the conductivity of underground materials and groundwater downstream of the pile. Electromagnetic and electrical methods are effective for investigation and monitoring of the contaminated plumes caused by coal waste piles and tailings impoundments. In order to investigate the environmental impact from a coal waste pile at the Alborz Sharghi coal washing plant, an EM34 ground conductivity meter was used on seven parallel lines in an E-W direction, downstream of the waste pile. Two-dimensional resistivity models obtained by the inversion of EM34 conductivity data identified conductive leachate plumes. In addition, quasi-3D inversion of EM34 data has confirmed the decreasing resistivity at depth due to the contaminated plumes. Comparison between EM34, VLF and DC-resistivity datasets, which were acquired for similar survey lines, agree well in identifying changes in the resistivity trend. The EM34 and DC-resistivity sections have greater similarity and better smoothness rather than those of the VLF model. Two-dimensional inversion models of these methods have shown some contaminated plumes with low resistivity.

Shiraz, Farzin Amirkhani; Ardejani, Faramarz Doulati; Moradzadeh, Ali; Arab-Amiri, Ali Reza



Mars' Magnetic Atmosphere: Ionospheric Currents, Lightning (or not), E&M; Subsurface Sounding, and Future Missions  

NASA Astrophysics Data System (ADS)

Mars' ionosphere has no obvious magnetic signs of large-scale, dust-produced lightning. However, there are numerous interesting ionospheric currents (some associated with crustal magnetic fields) which would allow for E&M; subsurface sounding.

Espley, J. R.; Connerney, J. E. P.



Cryo-EM of macromolecular assemblies at near-atomic resolution.  


With single-particle electron cryomicroscopy (cryo-EM), it is possible to visualize large, macromolecular assemblies in near-native states. Although subnanometer resolutions have been routinely achieved for many specimens, state of the art cryo-EM has pushed to near-atomic (3.3-4.6 Å) resolutions. At these resolutions, it is now possible to construct reliable atomic models directly from the cryo-EM density map. In this study, we describe our recently developed protocols for performing the three-dimensional reconstruction and modeling of Mm-cpn, a group II chaperonin, determined to 4.3 Å resolution. This protocol, utilizing the software tools EMAN, Gorgon and Coot, can be adapted for use with nearly all specimens imaged with cryo-EM that target beyond 5 Å resolution. Additionally, the feature recognition and computational modeling tools can be applied to any near-atomic resolution density maps, including those from X-ray crystallography. PMID:20885381

Baker, Matthew L; Zhang, Junjie; Ludtke, Steven J; Chiu, Wah



Analysis of the electrochemistry of hemes with Ems spanning 800 mV  

PubMed Central

The free energy of heme reduction in different proteins is found to vary over more than 18 kcal/mol. It is a challenge to determine how proteins manage to achieve this enormous range of Ems with a single type of redox cofactor. Proteins containing 141 unique hemes of a-, b-, and c-type, with bis-His, His-Met, and aquo-His ligation were calculated using Multi-Conformation Continuum Electrostatics (MCCE). The experimental Ems range over 800 mV from ?350 mV in cytochrome c3 to 450 mV in cytochrome c peroxidase (vs. SHE). The quantitative analysis of the factors that modulate heme electrochemistry includes the interactions of the heme with its ligands, the solvent, the protein backbone, and sidechains. MCCE calculated Ems are in good agreement with measured values. Using no free parameters the slope of the line comparing calculated and experimental Ems is 0.73 (R2 = 0.90), showing the method accounts for 73% of the observed Em range. Adding a +160 mV correction to the His-Met c-type hemes yields a slope of 0.97 (R2 = 0.93). With the correction 65% of the hemes have an absolute error smaller than 60 mV and 92% are within 120 mV. The overview of heme proteins with known structures and Ems shows both the lowest and highest potential hemes are c-type, whereas the b-type hemes are found in the middle Em range. In solution, bis-His ligation lowers the Em by ?205 mV relative to hemes with His-Met ligands. The bis-His, aquo-His, and His-Met ligated b-type hemes all cluster about Ems which are ?200 mV more positive in protein than in water. In contrast, the low potential bis-His c-type hemes are shifted little from in solution, whereas the high potential His-Met c-type hemes are raised by ?300 mV from solution. The analysis shows that no single type of interaction can be identified as the most important in setting heme electrochemistry in proteins. For example, the loss of solvation (reaction field) energy, which raises the Em, has been suggested to be a major factor in tuning in situ Ems. However, the calculated solvation energy vs. experimental Em shows a slope of 0.2 and R2 of 0.5 thus correlates weakly with Ems. All other individual interactions show even less correlation with Em. However the sum of these terms does reproduce the range of observed Ems. Therefore, different proteins use different aspects of their structures to modulate the in situ heme electrochemistry. This study also shows that the calculated Ems are relatively insensitive to different heme partial charges and to the protein dielectric constant used in the simulation. PMID:19003997

Zheng, Zhong; Gunner, M. R.




E-print Network

Instituto de Tecnologia de Alimentos, 6 Faculdade de Engenharia de Alimentos - UNICAMP, 7 Instituto de a quantificação dos teores de lipídios em alimentos. FAPERGS, EMBRAPA, PROGRUPE-UNISC e FUNDAP-UNISC #12;

Ferreira, Márcia M. C.


Histórico demográfico e filogeografia em populações brasileiras de Ardea alba egretta.  

E-print Network

??Foram estudadas populações de Ardea alba egretta (garça-branca-grande) da família Ardeidae (Aves), amostradas em quatro regiões brasileiras, com latitudes diferentes (Rio Grande do Sul, Pantanal,… (more)

Thaís Camilo Corrêa



EM-MAC: A Dynamic Multichannel Energy-Efficient MAC Protocol for Wireless Sensor Networks  

E-print Network

-up scheduling. EM-MAC substantially enhances wireless channel uti- lization and transmission efficiency while resisting wireless inter- ference and jamming by enabling every node to dynamically op- timize the selection

Shihada, Basem


V.S. Ramachandran and E.M. Hubbard The Phenomenology of Synaesthesia  

E-print Network

V.S. Ramachandran and E.M. Hubbard The Phenomenology of Synaesthesia Abstract: This article the phenomenology of synaesthesia in greater detail, raise several new questions that have emerged from recent

Ramachandran, Vilayanur S.

377 unified data resource for CryoEM  

PubMed Central

Cryo-electron microscopy reconstruction methods are uniquely able to reveal structures of many important macromolecules and macromolecular complexes., a joint effort of the Protein Data Bank in Europe (PDBe), the Research Collaboratory for Structural Bioinformatics (RCSB) and the National Center for Macromolecular Imaging (NCMI), is a global ‘one-stop shop’ resource for deposition and retrieval of cryoEM maps, models and associated metadata. The resource unifies public access to the two major archives containing EM-based structural data: EM Data Bank (EMDB) and Protein Data Bank (PDB), and facilitates use of EM structural data of macromolecules and macromolecular complexes by the wider scientific community. PMID:20935055

Lawson, Catherine L.; Baker, Matthew L.; Best, Christoph; Bi, Chunxiao; Dougherty, Matthew; Feng, Powei; van Ginkel, Glen; Devkota, Batsal; Lagerstedt, Ingvar; Ludtke, Steven J.; Newman, Richard H.; Oldfield, Tom J.; Rees, Ian; Sahni, Gaurav; Sala, Raul; Velankar, Sameer; Warren, Joe; Westbrook, John D.; Henrick, Kim; Kleywegt, Gerard J.; Berman, Helen M.; Chiu, Wah



História da ciência no estudo de modelos atômicos em livros didáticos de química.  

E-print Network

??Dissertação (mestrado)—Universidade de Brasília, Faculdade de Educação, Programa de Pós-Graduação em Educação, 2011. Esta dissertação tem por objetivo identificar a História da Ciência apresentada nos… (more)

Chaves, Lígia Maria Martinho Pereira



Reserva de Recursos e Qualidade de Servio em Redes de Computadores de Dbito Elevado  

E-print Network

Reserva de Recursos e Qualidade de Serviço em Redes de Computadores de Débito Elevado Elisabete trabalho insere-se na área das redes de comunicação de alta velocidade com garantia de qualidade de serviço desenvolvimento e a integração de mecanismos de garantia de qualidade de serviço (QoS) em protocolos de rede e de

Monteiro, Edmundo


ARTIGO INTERNET Bioengenharia de Clulas Estaminais e Redes de Comunicaes em debate  

E-print Network

NewsSearch ARTIGO INTERNET Bioengenharia de Células Estaminais e Redes de Comunicações em debate:// ... Bioengenharia de Células Estaminais e Redes de Comunicações em debate no IST Taguspark Com o objectivo de tecnológicas de vanguarda. Temáticas como a Bioengenharia de Células Estaminais, Redes de Comunicações, Gestão

Instituto de Sistemas e Robotica


SciMulator: Um Ambiente de Simulao de Workflows Cientficos em Redes P2P*  

E-print Network

SciMulator: Um Ambiente de Simulação de Workflows Científicos em Redes P2P* Jonas Dias1 , Carla desempenho ao utilizar a arquitetura SciMule para submissão de atividades de workflows científicos em redes P, equipe associada. VI Workshop de Redes Dinâmicas e Sistemas Peer-to-Peer 45 lirmm-00641030,version1-14Nov

Paris-Sud XI, Université de


Desenho e Avaliao do sistema BOA com base em Padres de Interfaces Sociais  

E-print Network

Desenho e Avaliação do sistema BOA com base em Padrões de Interfaces Sociais Alberto Rodrigues da-aprendizagem, como é o caso da plataforma Bolsa de Objectos de Aprendizagem (BOA). Este trabalho surge no seguimento dinamização e participação em comunidades suportadas pelo BOA. Este artigo, baseando-se na análise da

da Silva, Alberto Rodrigues


Circular Polarization Fractal Koch microstrip patch Antenna using single-fed EM coupled ring Resonators  

Microsoft Academic Search

This paper describes the design and analysis of a Circular Polarization Fractal Koch Antenna using single-fed electromagnetic (EM) coupled ring resonator at 2.4 GHz. By applying fractal Koch, the proposed antenna size is reduced about 5% compared to the square patch using single-fed EM coupled ring resonator antenna. The simulation process has been done by CST software. Simulation as well

M. A. M. Yusop; M. K. A. Rahim; M. F. Ismail; A. Wahid




E-print Network

) 6) Competência: mês/ano do pagamento; 7) Vencimento: dia/mês/ano do pagamento; 8) CNPJ/CPF do interessado; 9) Nome do interessado; 12) Emitir GRU; 13) Imprimir; 14) Pagamento no Banco do Brasil em a impressão para posterior pagamento no Banco do Brasil. 4. Esta ordem de serviço entra em vigor a partir de

Paraná, Universidade Federal do



E-print Network

perante o Consulado do Brasil em seu País. Exige-se do candidato estrangeiro o Certificado de Proficiência carteira do Conselho Regional de Enfermagem ou franquia provisória; · Fotocópia do CPF (para brasileiros ou recolhida em: BANCO DO BRASIL ­ 3. DA SELE��O: 3.1 Análise do Curriculum Vitae Observação: a) A nota mínima

Souza, Max O.


Seminario Informal (mas Formal!) 2006 Estrategias da Teoria de Reescrita em PVS  

E-print Network

4o Semin´ario Informal (mas Formal!) 2006 Estrat´egias da Teoria de Reescrita em PVS: considerac Teoria da Computac¸ ~ao Campus de Catal~ao & Departamento de Matem´atica Universidade Federal de Goi. A especificac¸ ~ao em PVS ´e organizada como uma colec¸ ~ao de Teorias. Uma Teoria ´e essencialmente feita de

Ayala-Rincón, Mauricio


Examination on Temperature Distribution of a Pyramidal EM-wave Absorber Under High Power Injection  

Microsoft Academic Search

In this research, temperature distribution of a pyramidal EM-absorber under high power injection is computed by a coupled method called FDTD-SIMPLE-MR method. In this method, both electromagnetic field and all the heat transmission phenomena such as heat transportation, heat transfer by air convention and heat radiation can be calculated. Moreover, temperature distribution of a pyramidal EM-absorber is examined experimentally by

Tetsuhiro Sasagawa; O. Hashimoto; S. Watanabe; T. Saito; H. Kurihara



Self-assembled monolayers improve protein distribution on holey carbon cryo-EM supports  

PubMed Central

Poor partitioning of macromolecules into the holes of holey carbon support grids frequently limits structural determination by single particle cryo-electron microscopy (cryo-EM). Here, we present a method to deposit, on gold-coated carbon grids, a self-assembled monolayer whose surface properties can be controlled by chemical modification. We demonstrate the utility of this approach to drive partitioning of ionotropic glutamate receptors into the holes, thereby enabling 3D structural analysis using cryo-EM methods. PMID:25403871

Meyerson, Joel R.; Rao, Prashant; Kumar, Janesh; Chittori, Sagar; Banerjee, Soojay; Pierson, Jason; Mayer, Mark L.; Subramaniam, Sriram



Acceleration of germination of super-hard rice cultivar EM10 by soaking with red onion.  


Red onion accelerated the germination of rice seeds and inhibited microbial infestation during germination. After germination with red onion for 16 h at 35 °C, super-hard rice EM10 showed a higher germination ratio (2.3 times), and it contained more GABA (2.3 times) and glucose (2.9 times) than that soaked without onion. Due to soaking with red onion, germinated EM10 was fortified with quercetin (18 mg/100 g). PMID:21389608

Nakamura, Sumiko; Ohtsubo, Ken'ichi



Óleos essenciais no controle pós-colheita de Colletotrichum gloeosporioides em mamão  

Microsoft Academic Search

RESUMO: Os subprodutos de plantas medicinais têm sido estudados como uma alternativa para o controle de doenças de plantas visando amenizar e\\/ou reduzir o uso abusivo de agrotóxicos, principalmente em condições pós-colheita. Assim, este trabalho teve como objetivo avaliar, in vitro e in vivo, o controle de Colletotrichum gloeosporioides, agente causal da antracnose do mamão em pós-colheita, por óleos essenciais


Fast, simultaneous and robust VLF-EM data denoising and reconstruction via multivariate empirical mode decomposition  

NASA Astrophysics Data System (ADS)

The measurement of Very Low Frequency Electromagnetic (VLF-EM) is important in many different applications, i.e, environmental, archeological, geotechnical studies, etc. In recent years, improving and enhancing VLF-EM data containing complex numbers (bivariate) was presented by several authors in order to produce reliable models, generally using univariate empirical mode decomposition (EMD). Applying univariate EMD separately on each data is problematic. This results in a different number of misaligned Intrinsic Mode Functions (IMFs) which can complicate the selection of some IMFs for denoising process. Thus, a filtering method based on the multivariate empirical mode decomposition (MEMD) approach to decompose simultaneously bivariate data is proposed. In this paper we address two issues by employing the recently introduced noise assisted MEMD (N-A MEMD) for improving bivariate VLF-EM data. Firstly, the N-A MEMD to decompose bivariate measurement of the VLF-EM data into IMFs and a residue is defined as VLF-EM signal or unwanted noise. Secondly, the proposed method is used to enhance VLF-EM data and to reject unwanted noise. Finally, the proposed method is applied to a synthetic data with two added sinusoids. To demonstrate the robustness of the N-A MEMD method, the method was tested on added-noise synthetic data sets and the results were compared to the Ensemble EMD (EEMD) and Bivariate EMD (BEMD). The N-A MEMD gave more robust and accurate results than the EEMD and BEMD methods and the method required less CPU time to obtain the IMFs compared to EEMD. The method was also tested on several field data sets. The results indicate that the filtered VLF-EM data based on the N-A MEMD make the data easier to interpret and to be analyzed further. In addition, the 2D resistivity profile estimated from the inversion of filtered VLF-EM data results was appropriate to the geological condition.

Sungkono; Bahri, Ayi S.; Warnana, Dwa D.; Monteiro Santos, Fernando A.; Santosa, Bagus J.




E-print Network

Lunardi Gomes M/D Denilson Rabelo M/D Emília Celma de Oliveira Pereira Garcia M Patricia P. Confessori Sartoratto M/D Paulo Cé Claure Nain Lunardi Gomes M/D Denilson Rabelo M/D Emília Celma de

Maier, Rudolf Richard



E-print Network

INPE-12145-TDI/969 ANÁLISE DE EPIS�DIOS DE TORNADO EM SANTA CATARINA: CARACTERIZA��O SIN�TICA E. Análise de episódios de tornados em Santa Catarina: caracterização sinótica e mineração de dados / I. P. O. Marcelino. ­ São José dos Campos: INPE, 2003. 223p. ­ (INPE-12145-TDI/969). 1.Tornados. 2.Tempestades


Inactivation of the Cystatin E/M Tumor Suppressor Gene in Cervical Cancer  

PubMed Central

We have previously localized a cervical cancer tumor suppressor gene to a 300 kb interval of 11q13. Analysis of candidate genes revealed loss of expression of cystatin E/M, a lysosomal cysteine protease inhibitor, in 6 cervical cancer cell lines and 9 of 11 primary cervical tumors. Examination of the three exons in four cervical cancer cell lines, 19 primary tumors, and 21 normal controls revealed homozygous deletion of exon 1 sequences in one tumor. Point mutations were observed in six other tumors. Two tumors contained mutations at the consensus binding sites for cathepsin L, a lysosomal protease over-expressed in cervical cancer. Introduction of these two point mutations using site directed mutagenesis resulted in reduced binding of mutated cystatin E/M to cathepsin L. Although mutations were not observed in any cell lines, four cell lines and 12 of 18 tumors contained promoter hypermethylation. Re-expression of cystatin E/M was observed after 5?aza 2-deoxycytidiene and/or Trichostatin A treatment of cervical cancer cell lines, HeLa and SiHa, confirming promoter hypermethylation. Ectopic expression of cystatin E/M in these two cell lines resulted in growth suppression. There was also suppression of soft agar colony formation by HeLa cells expressing the cystatin E/M gene. Re-expression of cystatin E/M resulted in decreased intracellular and extracellular expression of cathepsin L. Over-expression of cathepsin L resulted in increased cell growth which was inhibited by the reintroduction of cystatin E/M. We conclude, therefore, that cystatin E/M is a cervical cancer suppressor gene and that the gene is inactivated by somatic mutations and promoter hypermethylation. PMID:18506750

Veena, Mysore S.; Lee, Grant; Keppler, Daniel; Mendonca, Marc S.; Redpath, J. Leslie; Stanbridge, Eric J.; Wilczynski, Sharon P.; Srivatsan, Eri S.



AlmAnAc SUPPlEmEnT may 16, 1995 S-Making Connections  

E-print Network

AlmAnAc SUPPlEmEnT may 16, 1995 S- Making Connections Building Penn's electronic future Information #12;AlmAnAc SUPPlEmEnT may 16, 1995S- Abstract This statement of direction moves Penn toward a future and Computing, at or 5/898-0005. ©1995 Trustees of the University of Pennsylvania #12;AlmAnAc

Sharp, Kim


Colquio em homenagem ao centenrio da morte de Henri Poincar Rio de Janeiro  

E-print Network

Colóquio em homenagem ao centenário da morte de Henri Poincaré Rio de Janeiro 27 a 30 de novembro Henri Poincaré (Université Nancy 2) Em 2012, ocorrerá o primeiro centenário da morte do matemático morte de Poincaré, além de ser uma merecida homenagem a um cientista-filósofo, cujas idéias ainda hoje

Solodov, Mikhail V.



Microsoft Academic Search

Field surveys over the past several winters in the Gulf of St. Lawrence and off Labrador use helicopter-borne sensors to validate SAR ice signatures in RADARSAT imagery. Ice-plus- snow thickness profiles were collected using an electromagnetic (EM) induction system towed 15-25m above the ice surface by helicopter. Measurements from the laser altimeter contained in the EM system were high-pass filtered

I. K. Peterson; S. J. Prinsenberg; J. S. Holladay


Tide-driven fluid mud transport in the Ems estuary  

NASA Astrophysics Data System (ADS)

The Ems estuary, located at the border between The Netherlands and Germany, experienced a significant change of the hydrodynamic regime during the past decades, as a result of extensive river engineering. With the net sediment transport now being flood-oriented, suspended sediment concentrations have increased dramatically, inducing siltation and formation of fluid mud layers, which, in turn, influence hydraulic flow properties, such as turbulence and the apparent bed roughness. Here, the process-based understanding of fluid mud is essential to model and predict mud accumulation, not only regarding the anthropogenic impact, but also in view of the expected changes of environmental boundary conditions, i.e., sea level rise. In the recent past, substantial progress has been made concerning the understanding of estuarine circulation and influence of tidal asymmetry on upstream sediment accumulation. While associated sediment transport formulations have been implemented in the framework of numerical modelling systems, in-situ data of fluid mud are scarce. This study presents results on tide-driven fluid mud dynamics, measured during four tidal cycles aside the navigation channel in the Ems estuary. Lutoclines, i.e., strong vertical density gradients, were detected by sediment echo sounder (SES). Acoustic Doppler current profiles (ADCP) of different acoustic frequencies were used to determine hydrodynamic parameters and the vertical distribution of suspended sediment concentrations in the upper part of the water column. These continuous profiling measurements were complemented by CTD, ADV, and OBS casts. SES and ADCP profiles show cycles of fluid mud entrainment during accelerating flow, and subsequent settling, and the reformation of a lutocline during decelerating flow and slack water. Significant differences are revealed between flood and ebb phase. Highest entrainment rates are measured at the beginning of the flood phase, associated with strong current shear and rapid vertical mixing, inducing the highest instantaneous suspended sediment flux measured during the tidal cycle. During decelerating flood currents a lutocline is again established at a certain distance above the consolidated river bed. During slack water after the flood phase the concentration gradient increases and the thickness of the fluid mud layer below is constant, also during a significant part of the ebb phase. As water depth decreases during ebb, entrainment occurs only at the upper part of the fluid mud layer. The suspended sediment flux is low compared to the flood phase. These observations are further elaborated using turbulence parameters obtained from ADV and ADCP, explaining the difference between ebb and flood concerning the vertical location of the maximum concentration gradient. This study is funded through DFG-Research Center / Excellence Cluster "The Ocean in the Earth System". The Senckenberg Institute and the Federal Waterways Engineering and Research Institute are acknowledged for technical support.

Becker, Marius; Maushake, Christian; Winter, Christian



New Developments in the Technology Readiness Assessment Process in US DOE-EM - 13247  

SciTech Connect

A Technology Readiness Assessment (TRA) is a systematic, metric-based process and accompanying report that evaluates the maturity of the technologies used in systems; it is designed to measure technology maturity using the Technology Readiness Level (TRL) scale pioneered by the National Aeronautics and Space Administration (NASA) in the 1980's. More recently, DoD has adopted and provided systematic guidance for performing TRAs and determining TRLs. In 2007 the GAO recommended that the DOE adopt the NASA/DoD methodology for evaluating technology maturity. Earlier, in 2006-2007, DOE-EM had conducted pilot TRAs on a number of projects at Hanford and Savannah River. In March 2008, DOE-EM issued a process guide, which established TRAs as an integral part of DOE-EM's Project Management Critical Decision Process. Since the development of its detailed TRA guidance in 2008, DOE-EM has continued to accumulate experience in the conduct of TRAs and the process for evaluating technology maturity. DOE has developed guidance on TRAs applicable department-wide. DOE-EM's experience with the TRA process, the evaluations that led to recently developed proposed revisions to the DOE-EM TRA/TMP Guide; the content of the proposed changes that incorporate the above lessons learned and insights are described. (authors)

Krahn, Steven [Department of Civil and Environmental Engineering, Vanderbilt University, Nashville, TN, 37235 (United States)] [Department of Civil and Environmental Engineering, Vanderbilt University, Nashville, TN, 37235 (United States); Sutter, Herbert [Consultant, 910 Laurel Green Dr., North Canton, OH, 44720 (United States)] [Consultant, 910 Laurel Green Dr., North Canton, OH, 44720 (United States); Johnson, Hoyt [DOE-EM, 1000 Independence Ave., Washington, DC, 20585 (United States)] [DOE-EM, 1000 Independence Ave., Washington, DC, 20585 (United States)



Mutagenic effectiveness and efficiency of EMS, DES and gamma-rays in rice.  


Data on chlorophyll mutation frequency after treatment with EMS, DES and gamma-rays and sequential administration of gamma-rays and the two alkylating agents in three varieties of rice have been used to work out quantitatively the effectiveness and efficiency of each mutagen and combination treatment. For effectiveness, the order is EMS > DES and for efficiency it is EMS > DES > gamma-rays. In some sequential treatments (Gamma-rays + DES in 'IR8' and 'Basmati'; DES + gamma-rays in 'IR8' and 'Jhona'; Gamma-rays + EMS in 'IR8' and 'Basmati'; and EMS + gamma-rays in 'IR8', 'Jhona' and 'Basmati') mutation frequency is more than additive (synergistic) but these treatments are decisively less efficient because of their relatively high injurious effects in the M1. generation. EMS induces more albinas than gamma-rays do. The mutational spectrum patterns induced by gamma-rays and DES are alike. In general, combination treatments tend to increase the frequency of albinas over other types of chlorophyll mutants. PMID:24407841

Kaul, M L; Bhan, A K



Anisotropic 3D inversion of towed streamer EM data from the Troll West oil province (Invited)  

NASA Astrophysics Data System (ADS)

Obviating the need for ocean bottom receivers, the towed streamer EM system enables CSEM data to be acquired simultaneously with seismic over very large areas in frontier and mature basins for higher production rates and more cost effective than conventional marine CSEM. The towed streamer EM data are currently processed and delivered as a spectrum of frequency-domain responses. We apply a 3D anisotropic inversion methodology for towed streamer EM data that includes a moving sensitivity domain. Our implementation is based on the 3D contraction integral equation method for computing the EM responses and Fréchet derivatives, and uses the re-weighted regularized conjugate gradient method for minimizing the objective functional with focusing regularization. We present an actual case study for the 3D anisotropic inversion of towed streamer EM data from the Troll West oil province in the North Sea, and demonstrate our ability to image the Troll West Oil and Gas Provinces. We conclude that 3D anisotropic inversion of the data from the current generation of towed streamer EM system can adequately recover both the vertical and horizontal resistivities in anisotropic hydrocarbon-bearing formations.

Mattsson, J.; Midgley, J.; Zhdanov, M. S.; ENDO, M.



EM modeling for GPIR using 3D FDTD modeling codes  

SciTech Connect

An analysis of the one-, two-, and three-dimensional electrical characteristics of structural cement and concrete is presented. This work connects experimental efforts in characterizing cement and concrete in the frequency and time domains with the Finite Difference Time Domain (FDTD) modeling efforts of these substances. These efforts include Electromagnetic (EM) modeling of simple lossless homogeneous materials with aggregate and targets and the modeling dispersive and lossy materials with aggregate and complex target geometries for Ground Penetrating Imaging Radar (GPIR). Two- and three-dimensional FDTD codes (developed at LLNL) where used for the modeling efforts. Purpose of the experimental and modeling efforts is to gain knowledge about the electrical properties of concrete typically used in the construction industry for bridges and other load bearing structures. The goal is to optimize the performance of a high-sample-rate impulse radar and data acquisition system and to design an antenna system to match the characteristics of this material. Results show agreement to within 2 dB of the amplitudes of the experimental and modeled data while the frequency peaks correlate to within 10% the differences being due to the unknown exact nature of the aggregate placement.

Nelson, S.D.



Exact solution of the EM radiation-reaction problem for classical finite-size and Lorentzian charged particles  

Microsoft Academic Search

.  An exact solution is given to the classical electromagnetic (EM) radiation-reaction (RR) problem, originally posed by Lorentz.\\u000a This refers to the dynamics of classical non-rotating and quasi-rigid finite-size particles subject to an external prescribed\\u000a EM field. A variational formulation of the problem is presented. It is shown that a covariant representation for the EM potential\\u000a of the self-field generated by

C. Cremaschini; M. Tessarotto



Rock 'Em, Sock 'Em!  

ERIC Educational Resources Information Center

K-12-level competitive robotics is growing in popularity around the country and worldwide. According to one of the leading organizers of these events, FIRST--For Inspiration and Recognition of Science and Technology--250,000 students from 56 countries take part in its competitions. FIRST Tech Challenge (FTC) is a yearly event the organization puts…

Waters, John K.



Accurate 2D/3D electromagnetic modeling for time-domain airborne EM systems  

NASA Astrophysics Data System (ADS)

The existing industry software cannot deliver correct results for 3D time-domain airborne EM responses. In this paper, starting from the Fourier transform and convolution, we compare the stability of different modeling techniques and analyze the reason for instable calculations of the time-domain airborne EM responses. We find that the singularity of the impulse responses of EM systems at very early time that are used in the convolution is responsible for the instability of the modeling (Fig.1). Based on this finding, we put forward an algorithm that uses step response rather than impulse response of the airborne EM system for the convolution and create a stable algorithm that delivers precise results and maintains well the integral/derivative relationship between the magnetic field B and the magnetic induction dB/dt. A three-step transformation procedure for the modeling is proposed: 1) output the frequency-domain EM response data from the existing software; 2) transform into step-response by digital Fourier/Hankel transform; 3) convolve the step response with the transmitting current or its derivatives. The method has proved to be working very well (Fig. 2). The algorithm can be extended to the modeling of other time-domain ground and airborne EM system responses.Fig. 1: Comparison of impulse and step responses for an airborne EM system Fig. 2: Bz and dBz/dt calculated from step (middle panel) and impulse responses (lower panel) for the same 3D model as in Fig.1.

Yin, C.; Hodges, G.



Electrokinetic effect combined with surface-charge assumption: a possible generation mechanism of coseismic EM signals  

NASA Astrophysics Data System (ADS)

According to field observations, electromagnetic (EM) signals accompanying seismic waves can be recorded. The orders of magnitude of observed coseismic electric and magnetic signals associated with earthquakes are usually around 1 to 101 mV km-1 and 10-2 to 1 nT, respectively. In this paper, we carry out numerical simulation of coseismic EM signals associated with seismic waves due to electrokinetic effect and compare with field observations. The seismic source is represented by a finite fault measuring 15 × 9 km2 with a max slip displacement 1.5 m, corresponding to a Mw 5.9 earthquake. While using the EM surface boundary condition of continuous horizontal EM components, the magnetic signals only accompany the late-arriving S waves at receiver near the ground surface. This is obviously different from field observations. Thus, we adopt another EM surface boundary condition which assumes the ground surface carries surface charge. For the used half-space model, a surface-charge density magnitude |Qsc| in excess of 10-4 C m-2 is sufficient to make horizontal magnetic components clearly show up at the whole time duration of seismic waves. When |Qsc| increases, the contribution of surface-charge density to coseismic EM signals becomes more and more dominant comparing with that of the seismically induced streaming-current. We estimate the Qsc expected at the Earth's surface might be a value between -5 × 10-4 and -0.1 C m-2 by the comparison between numerical results and field observations. The vertical magnetic signals only accompany the late-arriving seismic waves, because they are theoretically only induced by SH wave. The field observation results of vertical magnetic signals may be resulted from the scattering effect or the seismic dynamo effect. We conclude that electrokinetic effect combined with surface-charge assumption is one possible generation mechanism of the observed coseismic EM signals.

Ren, Hengxin; Wen, Jian; Huang, Qinghua; Chen, Xiaofei



Estudo de soluções locais e cosmológicas em teorias do tipo tensor-escalar  

NASA Astrophysics Data System (ADS)

Teorias do tipo tensor-escalar são a mais simples extensão possí vel da Relatividade Geral. Nessas teorias, cujo modelo padrão é a teoria de Brans-Dicke, a curvatura do espaço-tempo, descrita por componentes tensoriais, aparece acoplada a um campo escalar que, de certo modo, representa uma variação na constante de acoplamento da gravitação. Tais teorias apresentam soluções locais e cosmológicas que, em determinados limites, recaem nas apresentadas pela Relatividade Geral, mas que em outros limites trazem novidades, tais como conseqüências observacionais da evolução de flutuações primordiais distintas daquelas previstas pela Relatividade Geral (ver, por ex., Nagata et al., PRD 66, p. 103510 (2002)). Graças a esta possibilidade de trazer à luz novidades em relação à gravitação, teorias do tipo tensor-escalar podem ser vistas como um interessante campo alternativo de pesquisas para soluções dos problemas de massa faltante (ou escura) e/ou energia escura. Seguindo tal linha, este trabalho, ainda em sua fase inicial, apresenta soluções gerais de teorias do tipo tensor-escalar para diversas situações, verificando-se em que consiste a divergência dessas soluções dos casos tradicionais possí veis na Relatividade Geral. Como exemplos das soluções aqui apresentadas pode-se destacar uma expressão geral para diferentes soluções cosmológicas englobando diferentes tipos de matéria (representados por diferentes equações de estado), e a expressão para uma solução local representando um buraco negro com rotação, similar à solução de Kerr da Relatividade Geral. Por fim, é importante ressaltar que, embora aqui apresentem-se poucos resultados novos, na literatura sobre o assunto a maior parte das soluções apresentadas limita-se a uns poucos casos especí ficos, tal como soluções cosmológicas apenas com curvatura nula, e que mesmo as soluções disponí veis são, em geral, pouco divulgadas e, portanto, pouco conhecidas, e é tal situação que este trabalho busca, em parte, reverter.

Silva E Costa, S.



EM-54 Technology Development In Situ Remediation Integrated Program. Annual report  

SciTech Connect

The Department of Energy (DOE) established the Office of Technology Development (EM-50) as an element of Environmental Restoration and Waste Management (EM) in November 1989. EM manages remediation of all DOE sites as well as wastes from current operations. The goal of the EM program is to minimize risks to human health, safety and the environment, and to bring all DOE sites into compliance with Federal, state, and local regulations by 2019. EM-50 is charged with developing new technologies that are safer, more effective and less expensive than current methods. The In Situ Remediation Integrated Program (the subject of this report) is part of EM-541, the Environmental Restoration Research and Development Division of EM-54. The In Situ Remediation Integrated Program (ISR IP) was instituted out of recognition that in situ remediation could fulfill three important criteria: Significant cost reduction of cleanup by eliminating or minimizing excavation, transportation, and disposal of wastes; reduced health impacts on workers and the public by minimizing exposure to wastes during excavation and processing; and remediation of inaccessible sites, including: deep subsurfaces; in, under, and around buildings. Buried waste, contaminated soils and groundwater, and containerized wastes are all candidates for in situ remediation. Contaminants include radioactive wastes, volatile and non-volatile organics, heavy metals, nitrates, and explosive materials. The ISR IP tends to facilitate development of in situ remediation technologies for hazardous, radioactive, and mixed wastes in soils, groundwater, and storage tanks. Near-term focus is on containment of the wastes, with treatment receiving greater effort in future years.

Not Available



Canibalismo em fêmeas de camundongo swiss expostas à irradiação ionizante durante a prenhez: alterações morfoló gicas associadas.  

E-print Network

??Fêmeas de camundongos Swiss irradiadas apresentaram comportamento canibalístico inesperado durante um experimento para avaliação de teste de memória operacional e de referência, não mencionado em… (more)

Lúcia de Araújo Piúma



Fraudes corporativas : uma análise das variáveis contábeis indicativas em empresas não financeiras de capital aberto no Brasil.  

E-print Network

??Trabalhos científicos com ferramental estatístico em contabilidade, utilizando variáveis contábeis indicativas, deram seus primeiros passos no estudo das fraudes corporativas no exterior no início da… (more)

Renato Ros



Estratégia de escalonamento de controladores PID baseado em regras Fuzzy para redes industriais foundation fieldbus usando blocos padrões.  

E-print Network

??Com o objetivo de se manter a padronização Foundation Fieldbus, neste trabalho são apresentados procedimentos para se implementar estratégias de controle inteligente, baseadas em escalonamento… (more)

Fábio Soares de Lima



Infecção por helmintos gastrintestinais em cães (Canis familiaris, Linnaeus, 1758) errantes procedentes do município de Recife - PE.  

E-print Network

??Os helmintos gastrintestinais assumem importância significativa na etiologia das gastrenterites em caninos, sendo as helmintoses de origem canina um problema mundial e de prevalência elevada,… (more)

Auxiliadora de Moraes Ostermann



Over one-half billion years of head conservation? Expression of an ems class gene in Hydractinia symbiolongicarpus (Cnidaria: Hydrozoa)  

PubMed Central

We report the isolation of an empty spiracles class homeodomain-containing gene, Cn-ems, from the hydrozoan Hydractinia symbiolongicarpus, the first gene of this class characterized in a lower metazoan. Cn-ems was found to be expressed in the head of gastrozooids, specifically in endodermal epithelial cells of the taeniolae of the hypostome. Cn-ems is not expressed in gonozooids, which lack taeniolae. Experimental conversion of the posterior region of the planula larva into head structures up-regulates expression of the gene. These findings establish that the association of ems-class genes with head structures preceded the evolution of bilateral symmetry. PMID:9520424

Mokady, Ofer; Dick, Matthew H.; Lackschewitz, Dagmar; Schierwater, Bernd; Buss, Leo W.



Elimination of error factors, affecting EM and seismic inversions  

NASA Astrophysics Data System (ADS)

EM or seismic data inversions are affected by many factors, which may conceal the responses from target objects. We address here the contributions from the following effects: 1) Pre-survey spectral sensitivity factor. Preliminary information about a target layer can be used for a pre-survey estimation of the required frequency domain and signal level. A universal approach allows making such estimations in real time, helping the survey crew to optimize an acquisition process. 2) Preliminary velocities' identification and their dispersions for all the seismic waves, arising in a stratified media became a fast working tool, based on the exact analytical solution. 3) Vertical gradients effect. For most layers the log data scatter, requiring an averaging pattern. A linear gradient within each representative layer is a reasonable compromise between required inversion accuracy and forward modeling complexity. 4) An effect from the seismic source's radial component becomes comparable with vertical part for explosive sources. If this effect is not taken into account, a serious modeling error takes place. This problem has an algorithmic solution. 5) Seismic modeling is often based on different representations for a source formulated either for a force or to a potential. The wave amplitudes depend on the formulation, making an inversion result sensitive to it. 6) Asymmetrical seismic waves (modified Rayleigh) in symmetrical geometry around liquid fracture come from S-wave and merge with the modified Krauklis wave at high frequencies. A detail analysis of this feature allows a spectral range optimization for the proper wave's extraction. 7) An ultrasonic experiment was conducted to show different waves appearance for a super-thin water-saturated fracture between two Plexiglas plates, being confirmed by comparison with theoretical computations. 8) A 'sandwich effect' was detected by comparison with averaged layer's effect. This opens an opportunity of the shale gas direct identification from the surface measurements.

Magomedov, M.; Zuev, M. A.; Korneev, V. A.; Goloshubin, G.; Zuev, J.; Brovman, Y.



Pre-flight risk assessment in Emergency Medical Service (EMS) helicopters  

NASA Technical Reports Server (NTRS)

The Emergency Medical Service (EMS) industry has been the subject of several television and newspaper articles (Harvey and Jensen, 1987) which emphasized the negative aspects, (e.g., fatalities and high accident rates), rather than the life saving services performed. Until recently, the accident rate of the EMS industry has been five times as high as that of other civil helicopters. This high accident rate has been coupled with the dramatic rise in the number of programs. The industry has built from a single service at its inception in 1972, to over 180 in 1987 (Spray, 1987), to the point that 93 percent of the contiguous U.S. is now covered by some type of EMS service. These factors prompted the National Transportation Safety Board (NTSB) to study the accidents that occurred between May 11, 1978 and December 3, 1986 (NTSB, 1988). The NTSB report concluded that 'Sound pilot judgment is central to safe flight operations.' They further stated that '... factors unique to EMS helicopter operations--such as the influence of the mission itself, program competition, and EMS program management perspectives--can drastically influence pilot judgment during the EMS mission.' One of the most difficult decisions that a pilot must make is whether to accept or decline a mission. A pre-flight risk assessment system (SAFE) was developed at NASA-Ames Research Center for civil EMS operations to aid pilots in making this decision objectively. The ability of the SAFE system to predict mission risk profiles was tested at an EMS facility. The results of this field study demonstrated that the usefulness of SAFE was highly dependent on the type of mission flown. SAFE is now being modified so that it can 'learn' with each mission flown. For example, after flying a mission to a particular site, an EMS pilot would input information about this mission into the system, such as new buildings, wires, or approach procedures. Then, the next time a pilot flew a similar mission or one to the same area, this additional information would be taken into account in computing a risk assessment.

Shively, R. J.



PWR loss-of-coolant accident analysis capability of the WRAP-EM system  

SciTech Connect

The modular computational system known as the Water Reactor Analysis Package (WRAP) has been extended to provide the computational tools required to perform a complete analysis of loss-of-coolant accidents (LOCAs) in pressurized water reactors (PWR). The new system is known as the WRAP-EM (Evaluation Model) system and will be used by NRC to interpret and evaluate reactor vendor EM methods and computed results. The system for PWR-EM analysis is comprised of several computer codes which have been developed to analyze a particular phase of a LOCA. These codes include GAPCON for calculation of initial fuel conditions, WRAP (the previously developd SRL analog of RELAP4/MOD5) for analysis of the system blowdown and refill, the FLOOD option in WRAP for analysis of the reflood phase, and FRAP for the calculation of the behavior of the hot fuel pin. In addition, a PWR steady-state initialization procedure has been developed to provide the initial operating state of the reactor system. The PWR-EM system is operational and is being evaluated to determine the adequacy and consistency of the physical models employed for EM analysis.

Gregory, M.V.; Beranek, F.



In vivo genotoxicity of EMS: statistical assessment of the dose response curves.  


EMS induced micronuclei and lacZ mutations in in vivo studies in mice with a clearly sublinear dose dependency. As reported elsewhere in this issue, NOEL dose values of between 25 mg/kg/day and 80 mg/kg/day were observed for the different endpoints and tissues analysed. Here we show that statistical assessment of the data provides solid support that the induction of mutagenic and clastogenic effects after in vivo treatment with the directly DNA damaging mutagen EMS adheres to a thresholded dose response relation. These data corroborate similar evidence obtained in in vitro studies. We conclude that cells are fully capable of repairing large amounts of DNA ethylations induced by EMS without experiencing elevated mutation frequencies. The stochastic, linear risk assessment model generally employed for DNA damaging genotoxins can therefore be refuted for EMS. While presently this conclusion cannot be generalized to other genotoxins a change of paradigm appears to be indicated at least for alkylating agents inducing a comparable type and spectrum of DNA lesions as EMS. PMID:19857797

Gocke, Elmar; Wall, Michael



Scalable and interactive segmentation and visualization of neural processes in EM datasets.  


Recent advances in scanning technology provide high resolution EM (Electron Microscopy) datasets that allow neuro-scientists to reconstruct complex neural connections in a nervous system. However, due to the enormous size and complexity of the resulting data, segmentation and visualization of neural processes in EM data is usually a difficult and very time-consuming task. In this paper, we present NeuroTrace, a novel EM volume segmentation and visualization system that consists of two parts: a semi-automatic multiphase level set segmentation with 3D tracking for reconstruction of neural processes, and a specialized volume rendering approach for visualization of EM volumes. It employs view-dependent on-demand filtering and evaluation of a local histogram edge metric, as well as on-the-fly interpolation and ray-casting of implicit surfaces for segmented neural structures. Both methods are implemented on the GPU for interactive performance. NeuroTrace is designed to be scalable to large datasets and data-parallel hardware architectures. A comparison of NeuroTrace with a commonly used manual EM segmentation tool shows that our interactive workflow is faster and easier to use for the reconstruction of complex neural processes. PMID:19834227

Jeong, Won-Ki; Beyer, Johanna; Hadwiger, Markus; Vazquez, Amelio; Pfister, Hanspeter; Whitaker, Ross T



Evaluation model calculations with the water reactor analysis package (WRAP-EM)  

SciTech Connect

The Water Reactor Analysis Package-Evaluation Model (WRAP-EM) is a modular system of computer codes designed to provide the safety analyst with the capability of performing complete loss-of-coolant calculations for both pressurized- and boiling-water reactor systems. The system provides a licensing-type calculation capability and thus contains most of the Nuclear Regulatory Commission-Approved EM options, as described in the Code of Federal Regulations, Title 10, Part 50, Appendix K. All phases of an accident (blowdown, refill, and reflood) are modeled. The WRAP consists of modified versions of five preexisting codes (RELAP4/MOD5, GAPCON, FRAP, MOXY, and NORCOOL), the necessary interfaces to permit automatic transition from one code to the next during the transient calculations, plus a host of user-convenience features to aid the analyst faced with a multitude of EM calculations. The WRAP has been verified against both calculated and experimental results.

Gregory, M.V.; Beranek, F.



EM algorithm applied for estimating non-stationary region boundaries using electrical impedance tomography  

NASA Astrophysics Data System (ADS)

EIT has been used for the dynamic estimation of organ boundaries. One specific application in this context is the estimation of lung boundaries during pulmonary circulation. This would help track the size and shape of lungs of the patients suffering from diseases like pulmonary edema and acute respiratory failure (ARF). The dynamic boundary estimation of the lungs can also be utilized to set and control the air volume and pressure delivered to the patients during artificial ventilation. In this paper, the expectation-maximization (EM) algorithm is used as an inverse algorithm to estimate the non-stationary lung boundary. The uncertainties caused in Kalman-type filters due to inaccurate selection of model parameters are overcome using EM algorithm. Numerical experiments using chest shaped geometry are carried out with proposed method and the performance is compared with extended Kalman filter (EKF). Results show superior performance of EM in estimation of the lung boundary.

Khambampati, A. K.; Rashid, A.; Kim, B. S.; Liu, Dong; Kim, S.; Kim, K. Y.



IPEP: Laboratory performance evaluation reports for management of DOE EM programs  

SciTech Connect

Environmental restoration program/project managers at DOE`s Office of Environmental Management (EM) are making important decisions based on analytical data generated by contracted laboratories. The Analytical Services Division, EM-263, is developing the Integrated Performance Evaluation Program (IPEP) to assess the performance of those laboratories, based on results from Performance Evaluation (PE) programs. The IPEP reports will be used by the laboratories to foster self-assessment and improvement. In addition, IPEP will produce PE reports for three levels of EM management (Operations/Project Offices, Area Program Offices, and Deputy Assistant Secretary Office). These reports will be used to assess whether contracted analytical laboratories have the capability to produce environmental data of the quality necessary for making environmental restoration and waste management decisions.

Hensley, J.E.; Lindahl, P.C.; Streets, W.E. [and others



Preliminary Seafloor Controlled Source EM Results From APPLE  

NASA Astrophysics Data System (ADS)

Certain events in the life cycle of oceanic lithosphere are dominantly two-dimensional. These include formation of crust at axial spreading centers and deformation at the lithosphere - asthenosphere boundary. These processes may result in an electrically anisotropic oceanic lithosphere by creating conductive pathways in preferred orientations. Controlled Source Electromagnetic (CSEM) soundings and Magnetotelluric (MT) soundings were made during the Anisotropy and Physics of the Pacific Lithosphere Experiment (APPLE), carried out in February/March 2001 approximately 600 km west of San Diego, California. Twenty seafloor electromagnetic field sensors were deployed: 4 long-wire CSEM recorders with 200 m electrode offsets, 6 high-frequency MT/CSEM recorders with two orthogonal 10 m offset electrodes and two orthogonal induction coil magnetometers, and 10 low-frequency MT recorders with a three-component fluxgate magnetometer and two orthogonal 10 m electric dipoles, 5 of which also recorded CSEM data. Every instrument was recovered, with data, during this primary cruise and a follow-up recovery cruise for the long-period instruments in August 2001. The deep-towed EM transmitter (DASI) was a 100 m horizontal electric dipole, which was towed in a 30 km radius circle around a central core of recorders. A radial tow was also performed. DASI transmitted a 4 Hz square wave throughout the CSEM phase of the experiment. Initial processing of the CSEM data reveals evidence of crustal anisotropy. In particular, transmitted electromagnetic energy is attenuated more strongly when propagating from west to east than from north to south. The difference in attenuation is about a factor of two, at a range of 30 km and a frequency of 4Hz. This confirms earlier results from the PEGASUS experiment, which proposed that oceanic lower crust and upper mantle with east-west trending lineaments of increased conductivity will exhibit greater attenuation of electric fields in the east-west direction. These lineaments may be deposits of conductive minerals (e.g. oxides, graphite) stretched out along the direction of plate motion.

Behrens, J. P.; MacGregor, L.; Constable, S.; Everett, M.



Facilitating EMS turnaround intervals at hospitals in the face of receiving facility overcrowding.  


The escalating national problem of oversaturated hospital beds and emergency departments (EDs) has resulted in serious operational impediments within patient-receiving facilities. It has also had a growing impact on the 9-1-1 emergency care system. Beyond the long-standing difficulties arising from ambulance diversion practices, many emergency medical services (EMS) crews are now finding themselves detained in EDs for protracted periods, unable to transfer care of their transported patients to ED staff members. Key factors have included a lack of beds or stretcher space, and, in some cases, EMS personnel are used transiently for ED patient care services. In other circumstances, ED staff members no longer prioritize rapid turnaround of EMS-transported patients because of the increasing volume and acuity of patients already in their care. The resulting detention of EMS crews confounds concurrent ambulance availability problems, creates concrete risks for delayed EMS responses to impending critical cases, and incurs regulatory jeopardy for hospitals. Communities should take appropriate steps to ensure that delivery intervals (time elapsing from entry into the hospital to physical transfer of patient care to ED staff) remain extremely brief (less than a few minutes) and that they rarely exceed 10 minutes. While recognizing that the root causes of these issues will require far-reaching national health care policy changes, EMS and local government officials should still maintain ongoing dialogues with hospital chief administrators to mitigate this mutual crisis of escalating service demands. Federal and state health officials should also play an active role in monitoring progress and compliance. PMID:16147474

Eckstein, Marc; Isaacs, S Marshal; Slovis, Corey M; Kaufman, Bradley J; Loflin, James R; O'Connor, Robert E; Pepe, Paul E



Influence of motivations for seeking ISO 14001 certification on perceptions of EMS effectiveness in China.  


This study examines the motivations of mainland Chinese facilities in seeking ISO 14001 certification and examines the linkages between these motivations and self-reports of the effectiveness of major environmental management system (EMS) components. In a sample of 128 facilities in Beijing, Shanghai, and Guangzhou, the main drivers for certification were reported to be to ensure regulatory compliance, to enhance the firm's reputation, and to improve environmental performance, in that order. Although motivation to achieve cost reductions were least emphasized, a broad range of motivations appears to be considered in the decision to seek certification to ISO 14001. Regression models linking these motivations to the EMS components suggests that internal motivations have an influence on most EMS components. One interesting exception to this, however, is that no significant relationship was observed between internal motivations and the promulgation of environmental objectives and targets. The relationships associated with external motivations for certification (i.e., those in response to customer and other stakeholder pressures) and EMS components, on the other hand, are weaker and tend to occur earlier in the process cycle. No significant relationships were found between motivations to reduce costs and perceptions of the effectiveness of EMS components. Overall, these findings suggest that ISO 14001, as currently being implemented in mainland China, may have a modestly useful role when used in combination with other policy mechanisms to move the Chinese economy toward more sustainable practices. It is asserted that the ISO standard could provide even greater benefits if Chinese registrars were more proactive in developing EMS in conjunction with even more rigorous third-party audits. PMID:15285401

Fryxell, Gerald E; Lo, Carlos Wing-Hung; Chung, Shan Shan



Maximum Likelihood from Incomplete Data via the EM Algorithm A. P. Dempster; N. M. Laird; D. B. Rubin  

E-print Network

. DEMPSTER,N. M. LAIRDand D. B. RDIN Harvard University and Educational Testing Service [Read before of an expectation step followed by a maximization step we call it the EM algorithm. The EM process is remarkable an exponential family whose maximum-likelihood estimates are easily computed, then each maximization step

Cheng, Jianlin Jack


Factor Analysis with EM Algorithm Never Gives Improper Solutions when Sample Covariance and Initial Parameter Matrices Are Proper  

ERIC Educational Resources Information Center

Rubin and Thayer ("Psychometrika," 47:69-76, 1982) proposed the EM algorithm for exploratory and confirmatory maximum likelihood factor analysis. In this paper, we prove the following fact: the EM algorithm always gives a proper solution with positive unique variances and factor correlations with absolute values that do not exceed one, when the…

Adachi, Kohei



Left-Handed-Media Simulation and Transmission of EM Waves in Subwavelength Split-Ring-Resonator-Loaded Metallic Waveguides  

Microsoft Academic Search

At microwave frequencies, hollow metallic waveguides behave in certain aspects as a ``one-dimensional plasma.'' This feature will be advantageously used for simulating the propagation of electromagnetic (EM) waves in left-handed metamaterials provided the hollow waveguide is periodically loaded with split ring resonators. It will be shown that EM transmission in this structure is feasible within a certain frequency band even

R. Marqués; J. Martel; F. Mesa; F. Medina



Rotating-bed reactor as a power source for EM gun applications  

SciTech Connect

Electromagnetic gun applications of the Rotating Bed Reactor (RBR) are examined. The RBR is a compact (approx. 1 m/sup 3/), (up to several thousand MW(th)), high-power reactor concept, capable of producing a high-temperature (up to approx. 300/sup 0/K) gas stream with a MHD generator coupled to it, the RBR can generate electric power (up to approx. 1000 MW(e)) in the pulsed or cw modes. Three EM gun applications are investigated: a rail gun thruster for orbit transfer, a rapid-fire EM gun for point defense, and a direct ground-to-space launch. The RBR appears suitable for all applications.

Powell, J.; Botts, T.; Stickley, C.M.; Meth, S.



Over-commitment of EMS Personnel in North Carolina with Implications for Disaster Planning.  


Abstract Background. While large-scale disasters are uncommon, our society relies on emergency personnel to be available to respond and act. Faith in their availability may lead to a false sense of security. Many emergency personnel obligate themselves to more than one agency and so may be overcommitted, leaving agencies with unfilled positions in a disaster. We sought to describe the frequency of overcommitment of emergency medical services (EMS) personnel in North Carolina. Methods. We conducted a cross-sectional study utilizing the Credentialing Information System (CIS) of the North Carolina Office of EMS. The CIS database manages demographic and certification information for all EMS personnel in North Carolina. The state is divided into 100 EMS systems based on county boundaries. Utilizing de-identified provider data from the CIS, we collected system(s) affiliation(s) and level of certification. To calculate an overcommitment rate per system, we divided the number of personnel with more than one system affiliation by total number of system roster personnel. To compare urbanicity and certification level with overcommitment, analysis of variance and the chi-square test were used, respectively. Results. North Carolina credentials 14,717 EMS providers (8,346 EMT, 1,709 EMT-intermediate (EMT-I), 4,662 EMT-paramedic (EMT-P)). Of these, 10,928 (74%) are affiliated with a single system. Of the 3,789 committed to more than one system, 3,020 (21%) were committed to two systems, 571 (4%) to three, 138 (1%) to four, and 60 (<1%) to five or more. EMT-Is and EMT-Ps were more likely to be overcommitted when compared to EMTs (37, 32, 20% respectively, p < 0.0001). Statewide, the median overcommitment rate for EMS systems was 24% (IQR 16-37%). Personnel working in systems servicing less densely populated areas were more likely to be overcommitted: 33% wilderness, 29% rural, 20% suburban and 11% urban (p < 0.0001). Additionally, 40% wilderness, 23% rural, 4% suburban, and 0% urban systems had >37% of their personnel engaged in 9-1-1 response in more than one system. Conclusion. Many EMS personnel have multiple EMS commitments. Disaster planners and emergency managers should consider overcommitment of emergency responders when calculating the work force on which they can rely. PMID:25289878

Watkins, Cameron; Shofer, Frances S; Delbridge, Theodore R; Mears, Greg D; Robertson, Jeff; Brice, Jane H



The longitudinal study of turnover and the cost of turnover in EMS  

PubMed Central

Purpose Few studies have examined employee turnover and associated costs in emergency medical services (EMS). The purpose of this study was to quantify the mean annual rate of turnover, total median cost of turnover, and median cost per termination in a diverse sample of EMS agencies. Methods A convenience sample of 40 EMS agencies was followed over a 6 month period. Internet, telephone, and on-site data collection methods were used to document terminations, new hires, open positions, and costs associated with turnover. The cost associated with turnover was calculated based on a modified version of the Nursing Turnover Cost Calculation Methodology (NTCCM). The NTCCM identified direct and indirect costs through a series of questions that agency administrators answered monthly during the study period. A previously tested measure of turnover to calculate the mean annual rate of turnover was used. All calculations were weighted by the size of the EMS agency roster. The mean annual rate of turnover, total median cost of turnover, and median cost per termination were determined for 3 categories of agency staff mix: all paid staff, mix of paid and volunteer (mixed), and all-volunteer. Results The overall weighted mean annual rate of turnover was 10.7%. This rate varied slightly across agency staffing mix: (all-paid=10.2%, mixed=12.3%, all-volunteer=12.4%). Among agencies that experienced turnover (n=25), the weighted median cost of turnover was $71,613.75, which varied across agency staffing mix: (all-paid=$86,452.05, mixed=$9,766.65, and all-volunteer=$0). The weighted median cost per termination was $6,871.51 and varied across agency staffing mix: (all-paid=$7,161.38, mixed=$1,409.64, and all-volunteer=$0). Conclusions Annual rates of turnover and costs associated with turnover vary widely across types of EMS agencies. The study’s mean annual rate of turnover was lower than expected based on information appearing in the news media and EMS trade magazines. Findings provide estimates of two key workforce measures – turnover rates and costs – where previously none have existed. Local EMS directors and policymakers at all levels of government may find the results and study methodology useful towards designing and evaluating programs targeting the EMS workforce. PMID:20199235

Patterson, P. Daniel; Jones, Cheryl B.; Hubble, Michael W.; Carr, Matthew; Weaver, Matthew D.; Engberg, John; Castle, Nicholas



Comunicantes domiciliares jovens de pacientes com TB pulmonar na região da grande Vitória (ES): um estudo de coorte* Juvenile household contacts aged 15 or younger of patients with pulmonary TB in the greater metropolitan area of Vitória, Brazil: a cohort study  

Microsoft Academic Search

Resumo Objetivo: Comparar aspectos clínicos, radiológicos e laboratoriais de contatos domiciliares, menores de 15 anos, de pacientes com cultura positiva para Mycobacterium tuberculosis. Métodos: Realizou-se um estudo de coorte comparando crianças e adolescentes (? 15 anos) que eram contatos domiciliares de casos de TB com baciloscopia e cultura positiva (grupo exposto, n = 100) ou com baciloscopia negativa e cultura

Ethel Leonor; Noia Maciel; Luiza Werner; Heringer Vieira; Lucília Pereira Dutra Molina; Rosana Alves; Reynaldo Dietze



Comparison of 3D OS-EM and 4D MAP-RBI-EM reconstruction algorithms for cardiac motion abnormality classification using a motion observer.  


Using a heart motion observer, we compared the performance of two image reconstruction techniques, a 3D OS-EM algorithm with post Butterworth spatial filtering and a 4D MAP-RBI-EM algorithm. The task was to classify gated myocardial perfusion (GMP) SPECT images of beating hearts with or without regional motion abnormalities. Noise-free simulated GMP SPECT projection data was generated from two 4D NCAT beating heart phantom models, one with normal motion and the other with a 50% motion defect in a pie-shaped wedge region-of-interest (ROI) in the anterior-lateral left ventricular wall. The projection data were scaled to clinical GMP SPECT count level before Poisson noise was simulated to generate 40 noise realizations. The noise-free and noisy projection data were reconstructed using the two reconstruction algorithms, parameters chosen to optimize the tradeoff between image bias and noise. As a motion observer, a 3D motion estimation method previously developed was applied to estimate the radial motion on the ROI from two adjacent gates. The receiver operating characteristic (ROC) curves were computed for radial motion magnitudes corresponding to each reconstruction technique. The area under the ROC curve (AUC) was calculated as an index for classification of regional motion. The reconstructed images with better bias and noise tradeoff were found to offer better classification for hearts with or without regional motion defects. The 3D cardiac motion estimation algorithm, serving as a heart motion observer, was better able to distinguish the abnormal from the normal regional motion in GMP SPECT images obtained from the 4D MAP-RBI-EM algorithm than from the 3D OS-EM algorithm with post Butterworth spatial filtering. PMID:21516240

Tang, Jing; Lee, Taek-Soo; He, Xin; Segars, W Paul; Tsui, Benjamin M W



In Situ Data Processing With Workflow-based Embedded Cyberinfrastructure (emCI)  

NASA Astrophysics Data System (ADS)

The decreasing cost of sensors and sensor networks has led to the wide scale adoption of this technology by large numbers of scientists for the collection of data in the field. At the same time, advances in both hardware and software have resulted in increased processing power at the sensor, enabling sensors in the field to do more than just data collection. With an increase in the number of sensors and deployments, scientists need tools for the configuration, operation, and debugging problems on their sensor networks. Furthermore, as the amount of data increases, scientists need a way to quickly and easily tag, process, archive, and share their datasets. Without proper tools, it is common for data processing to happen weeks or sometimes months after it is collected. This leads to important events being missed and makes real-time data analysis impossible. Additionally, because data is often manually processed through a series of repetitive steps, the analysis is susceptible to errors that are hard to track after data is combined and shared among researchers. Our emCI (embedded cyberinfrastructure) toolkit enables researchers to easily collect, analyze, and share their data. emCI provides a web-portal with upload/download capabilities that accept data in a number of different formats and ultimately can be used to archive data and share datasets among scientists. emCI uses an embedded general-purpose computer in the field for interfacing with sensors, coordinating data collection, and providing reliable data transfer to the emCI web portal. emCI relies on workflow technologies to automate data processing pipelines and to provide provenance information. In particular, emCI uses the Pegasus Workflow Management System as a core component, adapting it to the embedded computation environment. emCI allows scientists to distribute tasks among sensors in field and servers in the lab. In-situ processing using embedded workflows enable data reduction and validation in the field. Scientists can also create embedded workflows for data analysis and sensor retasking, allowing for much faster response to events in the field as well as disconnected operation from the emCI portal. Workflows executed at the emCI portal can include heavier computations, and combine data from multiple sensors by performing data analysis on data from multiple sources. The emCI portal also supports workflows for data transfers, visualization, and the automatic monitoring of the embedded infrastructure. We have prototyped the emCI toolkit in a project that uses automated digital cameras and weather stations for observing climate change based on plant phenology observations. In this application, embedded workflows are being used to coordinate the field data collection, reduce and analyze image data in the field, and retask cameras based on embedded triggers. We are currently in the process of moving our deployment from prototype to production stage at the Stunt Ranch UC Reserve in the Santa Monica Mountains.

Mehta, G.; Silva, F.; Graham, E. A.; Vahi, K.; Deelman, E.; Rundel, P.



Dynamic behaviour conception for EmI companion robot. Sbastien Saint-Aim, Cline Jost, Brigitte Le-Pvdic, Dominique Duhaut  

E-print Network

Dynamic behaviour conception for EmI companion robot. Sébastien Saint-Aimé, Céline Jost, Brigitte of satisfaction (86%) of the evaluation allowed us embeded static mode on our robotics platform: EmI ­ Emotional Model of Interaction. Now, we want add dynamics on EmI robot and add lifelike in its reactions

Paris-Sud XI, Université de


Scattering of Arbitrarily-Polarized EM Waves by a Discontinuity in a Grounded Dielectric Sheet and Propagation of EM Pulses Excited by AN Electric Dipole in Conducting Media.  

NASA Astrophysics Data System (ADS)

There are two parts in this thesis. In Part I, the two-dimensional problem of the interaction between an arbitrarily-polarized electromagnetic (EM) wave and a dielectric discontinuity in a grounded dielectric sheet is analyzed. An electric field integral equation (EFIE) is derived based on the dyadic Green's function for the field produced by induced polarization currents in the discontinuity region. Impressed electric fields consist of either plane waves incident from space above the dielectric sheet or surface waves supported by that sheet; both TE and TM polarizations are considered. The EFIE is solved using Galerkin's method with pulse and sinusoidal/piecewise -sinusoidal (SPS) basis functions. Computation of the inverse Fourier transform representation of the Green's function is performed by integration along the real axis, along the branch cuts directly, and along the branch cuts with a variable change. It is found that the excitation of the surface-wave mode reduces the back scattered radiation field for TE-polarized plane wave incidence. The reflected power for both TE- and TM-polarized surface-wave incidence is calculated, and it is found that the numerical results agree very well with those of existing studies. The EFIE is also solved iteratively using successive approximations. These approximate results agree very well with the direct MoM (Method of Moments) solutions to the EFIE. In Part II, the exact solutions are given for the transient EM fields excited by an electric dipole antenna with an impulsive current in a conducting medium. There exists an optimum waveform for the antenna current which can generate an EM pulse with a maximum intensity at a particular distance from the antenna. It is found that the EM fields of an EM pulse excited by an antenna in a conducting medium can be divided into two parts. The first part is an impulse wave which propagates with the speed of light (1/sqrt{muvarepsilon }) and decays exponentially. The second part builds up gradually and propagates slowly, and more importantly this part attenuates as an inverse power of distance which is a much slower rate than an exponential decay.

Song, Jiming


Extrac~ao de Propriedades Sociais em Redes Veiculares Felipe Cunha13  

E-print Network

Extrac¸~ao de Propriedades Sociais em Redes Veiculares Felipe Cunha13 , Aline Viana3 , Thiago atestar que as Redes Veiculares apresentam comportamento social. Os re- sultados comprovam a exist^encia de rotinas e propriedades sociais nas Redes Veiculares. Finalizando, discute-se sobre novas

Paris-Sud XI, Université de


Governo apresenta reforma da rede do Superior em Maro sem contributo dos reitores  

E-print Network

Governo apresenta reforma da rede do Superior em Março sem contributo dos reitores O Ministério da a racionalização da rede do Superior que vai passar pela cria- ção de consórcios entre universida- des e

Instituto de Sistemas e Robotica


Environmental Cost Analysis System (ECAS) Status and Compliance Requirements for EM Consolidated Business Center Contracts - 13204  

SciTech Connect

The Department of Energy (DOE) Office of Environmental Management (EM) has developed a web-accessible database to collect actual cost data from completed EM projects to support cost estimating and analysis. This Environmental Cost Analysis System (ECAS) database was initially deployed in early 2009 containing the cost and parametric data from 77 decommissioning, restoration, and waste management projects completed under the Rocky Flats Closure Project. In subsequent years we have added many more projects to ECAS and now have a total of 280 projects from 8 major DOE sites. This data is now accessible to DOE users through a web-based reporting tool that allows users to tailor report outputs to meet their specific needs. We are using it as a principal resource supporting the EM Consolidated Business Center (EMCBC) and the EM Applied Cost Engineering (ACE) team cost estimating and analysis efforts across the country. The database has received Government Accountability Office review as supporting its recommended improvements in DOE's cost estimating process, as well as review from the DOE Office of Acquisition and Project Management (APM). Moving forward, the EMCBC has developed a Special Contract Requirement clause or 'H-Clause' to be included in all current and future EMCBC procurements identifying the process that contractors will follow to provide DOE their historical project data in a format compatible with ECAS. Changes to DOE O 413.3B implementation are also in progress to capture historical costs as part of the Critical Decision project closeout process. (authors)

Sanford, P.C. [Consultant, 11221 E. Cimmarron Dr., Englewood, CO 80111 (United States)] [Consultant, 11221 E. Cimmarron Dr., Englewood, CO 80111 (United States); Moe, M.A. [EMCBC Office of Cost Estimating and Analysis, United States Department of Energy, 250 E. 5th Street, Suite 500, Cincinnati, OH 45202 (United States)] [EMCBC Office of Cost Estimating and Analysis, United States Department of Energy, 250 E. 5th Street, Suite 500, Cincinnati, OH 45202 (United States); Hombach, W.G. [Team Analysis, Inc., 2 Cardinal Park Drive, Suite 105A, Leesburg, VA 20175 (United States)] [Team Analysis, Inc., 2 Cardinal Park Drive, Suite 105A, Leesburg, VA 20175 (United States); Urdangaray, R. [Project Performance Corporation, 1760 Old Meadow Road, McLean, VA 22102 (United States)] [Project Performance Corporation, 1760 Old Meadow Road, McLean, VA 22102 (United States)



Accelerated Iterative Reconstruction for Positron Emission Tomography Based on the EM Algorithm for Maximum Likelihood Estimation  

Microsoft Academic Search

The EM method that was originally developed for maximum likelihood estimation in the context of mathematical statistics may be applied to a stochastic model of positron emission tomography (PET). The result is an iterative algorithm for image reconstruction that is finding increasing use in PET, due to its attractive theoretical and practical properties. Its major disadvantage is the large amount

Robert M. Lewitt; Gerd Muehllehner



Monte Carlo EM for Generalized Linear Mixed Models using Randomized Spherical Radial  

E-print Network

Monte Carlo EM for Generalized Linear Mixed Models using Randomized Spherical Radial Integration by Monte Carlo methods. However, in practice, the Monte Carlo sample sizes required for convergence for such methods. One solution is to use Monte Carlo approximation, as proposed by Wei and Tanner (1990

Booth, James


Memória fonológica em crianças bilíngues bimodais e crianças com implante coclear  

PubMed Central

RESUMO Este estudo comparou o desempenho de crianças bilíngues bimodais ouvintes (filhas de pais surdos) e crianças surdas usuárias de implante coclear (filhas de pais surdos e de pais ouvintes), com diferentes contextos de acesso à Língua Brasileira de Sinais (Libras), em tarefas que envolvem memória fonologica. Os testes utilizados foram: Teste de Pseudopalavras (Santos e Bueno, 2003) e Teste de Pseudosinais (desenvolvido pelos pesquisadores responsáveis pelo Projeto ‘Desenvolvimento Bilíngue Bimoda’). Além disso, foram incluídos dois grupos de controle, formados por crianças surdas (usuarias de Libras), e adultos bilíngues bimodais ouvintes. Na análise dos resultados, em relação ao desempenho entre os dois grupos testados foi constatado que o grupo de crianças bilíngues bimodais ouvintes apresentou desempenho superior, nos dois testes. No entanto, ao ser analisado o desempenho da criança surda usuaria de implante coclear, filha de pais surdos, que possui acesso irrestrito à Libras e comparado com o das crianças surdas usuárias de implante coclear, que possuem acesso restrito à Libras, foi constatado que o seu desempenho foi semelhante ao do grupo de crianças bilíngues bimodais ouvintes. As crianças surdas usuárias de implante coclear com acesso restrito à Libras e, portanto, com acesso maior ao Português apresentaram escores mais baixos nas tarefas, principalmente do teste em Português. Os resultados sugerem que as crianças surdas usuárias de implante coclear em processo de aquisição da línguagem podem se beneficiar com o acesso irrestrito à Libras, atingindo inclusive desempenho semelhante a de crianças bilíngues bimodais ouvintes. PMID:25110473

de Quadros, Ronice Müller; Cruz, Carina Rebello; Pizzio, Aline Lemos



Conhecimento e Dinamismo Psíquico em Dois Sermões no Brasil Colonial1  

Microsoft Academic Search

RESUMO - O trabalho aborda as relações entre conhecimento e dinamismo psíquico em dois sermões pregados no Brasil por Eusebio de Mattos, no século XVII e por Bento da Trindade, no século XVIII. Uma concepção de conhecimento afetivo implicando as atividades das potências anímicas defi ne o êxtase dos místicos como ato do entendimento aplicado ao objeto supremo, Deus. Esta

Marina Massimi


An EM Algorithm for Fitting Two-Level Structural Equation Models  

ERIC Educational Resources Information Center

Maximum likelihood is an important approach to analysis of two-level structural equation models. Different algorithms for this purpose have been available in the literature. In this paper, we present a new formulation of two-level structural equation models and develop an EM algorithm for fitting this formulation. This new formulation covers a…

Liang, Jiajuan; Bentler, Peter M.



Lessons in Generative Design, Publishing, and Circulation: What EM-Journal's First Year Has Taught Us  

ERIC Educational Resources Information Center

"EM-Journal" is a flexibly refereed online journal featuring writing produced by students of Eastern Michigan University. The journal showcases a variety of documents (articles, essays, reports, etc.) written and designed by students enrolled in EMU's First-Year Writing (FYW) program, in selected Writing Intensive (WI) courses affiliated with the…

Rosinski, Jana; Lonsdale, Chelsea; Morrison, Becky; Mueller, Derek; Nannini, Adam



Instituto Nacional de Pesquisas Espaciais Exame para o curso de ps-graduao em Astrofsica  

E-print Network

for Extraterrestrial Intelligence), afirmava que o grande radiotelescópio de Arecibo, em Porto Rico, "pode detectar um magnético? b) A que aceleração ele é submetido? #12;6. Frank Drake, um dos criadores do projeto SETI (Search


iGrace emotional computational model for EmI companion robot.  

E-print Network

0 iGrace ­ emotional computational model for EmI companion robot. S´ebastien Saint. Introduction A new challenge in Robotics is to create systems capable of behaviour enhancement due modality in human communication. Robotherapy, a field in robotics, attempts to apply the principles

Paris-Sud XI, Université de


ICE-EM RNSA 2007 Workshop on Pairing Based Cryptography 1 Certificateless Cryptography I  

E-print Network

ICE-EM RNSA 2007 Workshop on Pairing Based Cryptography 1 Certificateless Cryptography I Kenny on Pairing Based Cryptography 2 Overview This talk and the next: · Motivating and introducing certificateless (public key) cryptography · Certificateless Encryption (CLE) and its security · Specific and generic

Paterson, Kenny


A Carreira Universitria em Portugal Paulo J. Ferreira, Ph.D  

E-print Network

A Carreira Universitária em Portugal Paulo J. Ferreira, Ph.D University of Texas Austin, Texas, USA Poderá parecer incrível, mas de acordo com os actuais estatutos da carreira

Ferreira, Paulo J.


Introduc~ao ao LATEX 2 Ou LATEX2 em 105 minutos  

E-print Network

´a-lo atualizado para o LATEX2 por J¨org Knappen em CTAN:/tex-archive/info/lshort/german Enquanto preparava este! Rosemary Bailey, Friedemann Brauer, Jan Busa, Markus Br¨uhwiler, David Carlisle, Jos´e Carlos Santos, Mike

Reverbel, Francisco


New Jersey's EMS response to Superstorm Sandy: a case study of the emergency management assistance compact.  


In the United States, understanding the Emergency Management Assistance Compact (EMAC) is critical to responding to a natural disaster or manmade event. Recently, the State of New Jersey responded to Superstorm Sandy and implemented the EMAC system by requesting ambulances to aid in the Emergency Medical Services response. New Jersey's response to Superstorm Sandy was unprecedented in that this storm affected the entire state and EMS community. New Jersey's EMS community and infrastructure were impacted greatly, despite years of planning and preparation for such an event. Once received, out-of-state EMS resources were integrated into New Jersey's emergency management and EMS systems. In this report, each phase of the EMAC in New Jersey is explored, from how the response was coordinated to how it ultimately was executed. The state coordinated its response on multiple levels and, as such, tested the practical applicability of the EMAC process and employed best practices and solutions to issues that arose. These best practices and solutions may prove invaluable for any state or territory that may activate the EMAC system for emergency medical service resources. PMID:24844291

Clancy, Terry; Christensen, Kenneth; Cortacans, Henry P




E-print Network

vagas oferecidas para candidatos residentes no Brasil é: 2.1.1 Mestrado Acadêmico: 25 (vinte e cinco inscrição, os candidatos residentes no Brasil deverão, obrigatoriamente, entregar, pessoalmente ou por 001/2011-PGPDS, nome completo do candidato e número do CPF, na Secretaria de Pós-Graduação em

Lucero, Jorge Carlos


The VLF-EM imaging of potential collapse on the LUSI embankment  

NASA Astrophysics Data System (ADS)

Collapse and overtopping repeatedly occur in LUSI Embankment. Discontinuities (crack or fracture) in the embankment are major reasons for embankment failures or collapses. Very-low frequency electromagnetic (VLF-EM) measurement is essentially a non-destructive technique which displays subsurface 2-D cross section of resistivity. The cross section result has the possibility of detecting discontinuities and liquid saturation in embankment before it collapsed by observing which part of it in the cross section has low resistivity. This paper presents results of a survey conducted at the LUSI embankment in Eastern Java, Indonesia in a part of potential collapse. VLF-EM profiles measured along the embankment crest provided an overview of the whole embankment and served to detect anomalous zones. The noise assisted multivariate empirical mode decomposition (NA-MEMD) is applied to reject unwanted VLF-EM noise and Inv2DVLF software is applied to obtain result of 2-D resistivity models. In the selected area, the drill log and the standard penetration test (SPT) value gave detailed information about subsurface layer below embankment. This information is valuable for supporting 2-D resistivity image obtained from VLF-EM data inversion. Furthermore, the low resistivity in embankment layer is associated to discontinuities (fracture, crack or fault) along the embankment which caused its collapse.

Sungkono; Husein, Alwi; Prasetyo, Hardi; Bahri, Ayi S.; Monteiro Santos, Fernando A.; Santosa, Bagus J.



O METRO E A CIDADE. Das representaes da causalidade integrao transporte/ordenamento em Paris.  

E-print Network

1 O METRO E A CIDADE. Das representações da causalidade à integração transporte/ordenamento em Paris. _____________________ Palavras-chave : metro ­ causalidade ­ avaliação ­ efeitos ­ infra entre a expansão do metro parisiense nos arredores da capital francesa e o tecido urbano e social do

Paris-Sud XI, Université de


Original identification technique of passive EM sensors using loaded transmission delay lines  

Microsoft Academic Search

This paper presents a proof of concept of an original identification technique of passive EM sensor cells. Previous works published by the authors have shown the feasibility of high sensitivity passive sensor Microsystems based on the electromagnetic transduction principle. More, other works, published by the same authors, have demonstrated the feasibility of a wireless interrogation technique of such passive measurement

M. M. Jatlaoui; F. Chebila; S. Bouaziz; P. Pons; H. Aubert



Assessing the credibility of a target zone: evidence from the EMS  

Microsoft Academic Search

This paper provides some new evidence on the credibility of the Exchange Rate Mechanism (ERM) of the European Monetary System (EMS). The study differs from previous research in the literature in three main respects. First, the main contribution is the use of several credibility indicators, some of which have never been applied before to all of the currencies under study.

Francisco Ledesma-Rodríguez; Manuel Navarro-Ibáñez; Jorge Pérez-Rodríguez; Simón Sosvilla-Rivero



Study of temperature distribution of a pyramidal EM-wave absorber under high power injection  

Microsoft Academic Search

Utilization of electromagnetic absorbers under high power is increasing. The absorbers are used in anechoic chambers for estimation of performance of high power radars. Variation of the absorption characteristics of the absorbers under such condition is expected, due to the generation of heat or temperature change. In this paper, first temperature distribution of a pyramidal EM-wave absorber under high power

Shinya Watanabe; Tetsuhiro Sasagawa; Osamu Hashimoto; Toshifumi Saito



Prof. Dr. Ir. Joost-Pieter Katoen Prof. em. Dr. Klaus Indermark  

E-print Network

Staff · Faculty Prof. Dr. Ir. Joost-Pieter Katoen Prof. em. Dr. Klaus Indermark AOR Priv.-Doz. Dr Chakraborty (IIT Delhi, India) Taolue Chen (University of Oxford, UK) Andreas Classen (University of Namur, B success both scientifically as well as socially. #12;Other highlights during 2011: - Joost-Pieter Katoen

Ábrahám, Erika


Prof. Dr. Ir. Joost-Pieter Katoen Prof. em. Dr. Klaus Indermark  

E-print Network

Staff · Faculty Prof. Dr. Ir. Joost-Pieter Katoen Prof. em. Dr. Klaus Indermark apl. Prof. Dr Bundeswehr München, GER) B. Srivathsan (LaBRI, Bordeaux, FRA) Daniel Stan (ENS Cachan, FRA) Gerjan Stokkink of post-doctoral research. Dino Distefano was one of the first PhD stu- dents supervised by Joost

Ábrahám, Erika


9th EMS Annual Meeting & 9th European Conference on Applications of Meteorology (ECAM)  

E-print Network

9th EMS Annual Meeting & 9th European Conference on Applications of Meteorology (ECAM) 28 September Meteorological Society 9th Annual Meeting and the 9th European Conference on Applications of Meteorology at the UK Met Office. I am very grateful to the European Meteorological Society for enabling me to attend

Williams, Paul


An EM Algorithm for Maximum Likelihood Estimation of Process Factor Analysis Models  

ERIC Educational Resources Information Center

In this dissertation, an Expectation-Maximization (EM) algorithm is developed and implemented to obtain maximum likelihood estimates of the parameters and the associated standard error estimates characterizing temporal flows for the latent variable time series following stationary vector ARMA processes, as well as the parameters defining the…

Lee, Taehun



Regressão múltipla stepwise e hierárquica em Psicologia Organizacional: aplicações, problemas e soluções  

Microsoft Academic Search

Resumo Este artigo discute algumas aplicações das técnicas de análise de regressão múltipla stepwise e hierár- quica, as quais são muito utilizadas em pesquisas da área de Psicologia Organizacional. São discuti- das algumas estratégias de identificação e de solução de problemas relativos à ocorrência de erros do Tipo I e II e aos fenômenos de supressão, complementaridade e redundância nas

Gardênia Abbad; Cláudio Vaz Torres



Teamwork. University of Miami uses competition to sharpen EMS team performance.  


Many argue that experience is the best teacher. However, it's often dangerous for the patient and impractical for an EMS system to assess prehospital providers in their actual working environment. Simulated scenario competition fosters clearer thinking and translates into more effective action and enhanced patient outcomes during true emergencies. PMID:11771373

Miller, G T; Gordon, D L; Issenberg, S B; LaCombe, D M; Brotons, A A



EM2I: A Term in Search of the Infrastructure of Electronic Markets  

E-print Network

be treated as a research area for the research specialists of business information systems and electronic, in [34], "electronic markets" had a set of e-commerce business models such as "e-shop", "e- procurementEM2I: A Term in Search of the Infrastructure of Electronic Markets Jingzhi Guo Department

Guo, Jingzhi


Controlling protein adsorption on graphene for cryo-EM using low-energy hydrogen plasmas  

E-print Network

Controlling protein adsorption on graphene for cryo-EM using low-energy hydrogen plasmas Christopher J. Russo1 and Lori A. Passmore1 1Medical Research Council Laboratory of Molecular Biology taken before and after 80 s hydrogen plasma treatment used to measure change in lattice constant vis

Cai, Long


The Use of Electronic Monitoring (EM) Technologies in Alaskan Fisheries Prepared by  

E-print Network

species catch (PSC) on a factory trawler and monitor and enumerate discard aboard rockfish catcher vessels program. These issues included: 1) the cost of implementing EM, which can be similar to, or higher than of Alaska Rockfish Fishery Alaska Groundfish Databank, in conjunction with NMFS, has conducted several


Deteco de Ativao em Ressonncia Nuclear Magntica Funcional do Crebro PEDRO PAULO DE M. OLIVEIRA JR  

E-print Network

as a means to map the sensorial and motor activities into the brain. This paper presents an image processing images collected with a 1,5 Tesla MRI Scanner. Results, also presented here, indicate the feasibility de sinal em exames funcionais é da ordem de 5%, num aparelho de 1.5 Tesla. Isto #12;significa que


Fuzzy Comprehensive Evaluation of River Health Using (1\\/2, 2) EM Method  

Microsoft Academic Search

In this paper, river health evaluation is decomposed into a hierarchical structure. Weights for each index of each grade are determined with the (1\\/2,2) EM method. The relative membership degree of different evaluation grade standards is then calculated with a fuzzy comprehensive evaluation based on fuzzy theory. The results present a comprehensive evaluation of river health and a scientific basis

Zhijie Yin; Yuhui Guan; Alexander Baron; Leihua Geng



Effect of EM on Soil Properties and Nutrient Cycling in a Citrus Agroecosystem  

Microsoft Academic Search

To test the effects of Effective Microorganisms (EM) on soil and on natural cycling of nutrients, a field investigation was conducted with citrus in the State of São Paulo, Brazil. A Typic Hapludox soil predominates as a deep, well-drained, clay soil with high hydrogen and aluminum contents and low base saturation, The organic matter content of the soil is moderate,

D. Paschoal; S. K. Homma; M. J. A. Jorge; M. C. S. Nogueira


FERMAT: A high frequency em scattering code from complex scenes including objects and environment  

Microsoft Academic Search

In this paper, a fast high frequency analysis method of complex 3D targets and environment is achieved by coupling electromagnetic asymptotic formulations and shooting and bouncing ray (SBR) approach. Different applications of the tools from EM fields evaluation are then presented.

H. J. Mametsa; S. Laybros; A. Berges; P. F. Combes; P. N'Guyen; P. Pitot



Magnetic Properties of the Basalt in Hole EM 7, Mohole Project  

Microsoft Academic Search

The average direction of the remanent magnetization of the basalt layer at the bottom of hole EM 7 is inclined 36 ø above tile horizontal, indicating that the layer is reversely magnetized. Detailed demagnetization experiments with alternating magnetic fields to 800 oer- steds peak intensity indicate that the drilling operations did not remagnetize the basalts. The natural magnetization is extremely

Allan Cox; Richard R. Doell



Use of the Electromagnetic-Induction Meter (EM38) as a Tool in Managing Salinisation  

NASA Astrophysics Data System (ADS)

Utilisation of an EM38 electromagnetic-induction meter is a cost-effective method for assessing field salinity and for experiments on the salt tolerance of crops. The EM38 meter can be used to map the distribution and severity of salinity. The instrument must be calibrated for temperature, moisture, texture, and other soil factors, such as the presence of magnetic minerals. The meter can be carried by an operator and readings recorded manually; it can be towed behind an all-terrain vehicle to map in a preset grid; or it can be used randomly with a Global Positioning System and data-logging equipment to map large areas. In field experiments in Alberta, Canada, the EM38 was used to help assess salt tolerance of 28 species of trees and 28 species of forage and turf grasses. In similar experiments in Western Australia, the usefulness of the EM38 meter was evaluated in helping to predict survival and growth of Eucalyptus globulus and pastures in saline soils. These techniques are now being incorporated into salinity-management strategies.

McKenzie, R. C.; George, R. J.; Woods, S. A.; Cannon, M. E.; Bennett, D. L.



Description and comparison of algorithms for correcting anisotropic magnification in cryo-EM images  

E-print Network

Single particle electron cryomicroscopy (cryo-EM) allows for structures of proteins and protein complexes to be determined from images of non-crystalline specimens. Cryo-EM data analysis requires electron microscope images of randomly oriented ice-embedded protein particles to be rotated and translated to allow for coherent averaging when calculating three-dimensional (3-D) structures. Rotation of 2-D images is usually done with the assumption that the magnification of the electron microscope is the same in all directions, a condition that has been found to be untrue with some electron microscopes when used with the settings necessary for cryo-EM with a direct detector device (DDD) camera (Grant and Grigorieff, in preparation). Correction of images by linear interpolation in real space has allowed high-resolution structures to be calculated from cryo-EM images for symmetric particles (Grant and Grigorieff, in preparation). Here we describe and compare a simple real space method and a somewhat more sophisticat...

Zhao, Jianhua; Benlekbir, Samir; Rubinstein, John L



O Feminino na Mídia: novos argumentos em busca de novos sentidos 1  

Microsoft Academic Search

Este artigo se propõe a discutir sob o ponto da Aná lise Crítica de Discurso (ACD) a inserção de novos discursos nas peças de publicidad e, direcionadas ao público feminino. Para elaborar uma breve análise toma-se como objeto recortes da campanha da Linha Natura de cosméticos. Os pressupostos teóricos estã o em Baktin (2004), no que diz respeito à representação

Eliane Penha Mergulhão Dias


O pragmatismo em economia : bases filosóficas para uma interpretação do discurso econômico  

Microsoft Academic Search

O trabalho tem por objetivo trazer elementos da corrente filosófica do pragmatismo para a discussão metodológica em economia, particularmente no que diz respeito a teoria da verdade e suas implicações para o debate epistemológico. Após apresentar as contribuições dos pioneiros do pragmatismo William James, John Dewey e Charles S. Peirce e discutir aspectos da obra de W. Quine e Richard

Paulo Sérgio de Oliveira Simões Gala; Danilo Fernandes Araújo; José Márcio Rego




E-print Network

188 Oliveira et al. Quim. Nova SISTEMA DE INJE��O EM FLUXO ESPECTROFOTOM�TRICO PARA MONITORAR injection analysis; foto-Fenton. ArtigoQuim. Nova, Vol. 24, No. 2, 188-190, 2001. INTRODU��O A reação foto

Jardim, Wilson de Figueiredo


Maximum Likelihood Computations with Repeated Measures: Application of the EM Algorithm  

Microsoft Academic Search

The purpose of this article is to consider the use of the EM algorithm (Dempster, Laird, and Rubin 1977) for both maximum likelihood (ML) and restricted maximum likelihood (REML) estimation in a general repeated measures setting using a multivariate normal data model with linear mean and covariance structure (Anderson 1973). Several models and methods of analysis have been proposed in

Nan Laird; Nicholas Lange; Daniel Stram




E-print Network

CHARACTERIZATION OF EM SEA CLUTTER WITH -STABLE DISTRIBUTION Anthony Fiche1 , Jean-Christophe Cexus clutter are highly non-stationnary. The probability density function of the RCS has been mainly studied with the K distribution. In [1], the authors proved that the K distribution fits sea clutter data well

Paris-Sud XI, Université de


Are you under stress in EMS. Understanding the slippery slope of burnout and PTSD.  


Burnout and PTSD are closely linked and often underreported in EMS. EMS classrooms do little or nothing to prepare providers for the inherent emotional stresses of emergency response and the "thick skin" culture of EMS may make many providers apprehensive about sharing their true feelings. Burnout is triggered by many of the same stresses that lead to the symptoms of PTSD and providers experiencing burnout that doesn't resolve within a few weeks may actually be experiencing PTSD. Be mindful of yourself and your fellow coworkers, particularly after a very traumatic response. And remember traumatic responses don't need to be as dramatic as Sept. 11, New Orleans after Hurricane Katrina or the Aurora, CO shootings to bother an EMS worker. In contrast, these are the calls where providers often receive the most attention. Instead, watch for the new father who just performed CPR on an infant the same age as his own, or the provider who just watched his or her friend die following a motor vehicle collision. Pay attention to yourself and colleagues, and be responsible and honest with yourself and others about when coping strategies are enough, and when they aren't. Finally, don't ever be afraid to seek help. PMID:23097838

Collopy, Kevin T; Kivlehan, Sean M; Snyder, Scott R




Microsoft Academic Search

RESUMO — O presente trabalho trata das espécies de Arales ocorrentes em lagoas de uma área do semi-árido baiano. A ordem apresenta, no local, duas famílias com cinco espécies: Lemna valdiviana Phil., Lemna aequinoctialis Welwitsch, Wolffiella lingulata (Hegelm.) Hegelm. e Wolffia columbiana Karsten (LEMNACEAE) e Pistia stratiotes L. (ARACEAE). PALAVRAS-CHAVE: Arales; plantas aquáticas; Lemnaceae; Araceae. ABSTRACT — This paper presents

Márcia Gonçalves Bezerra; Flávio França



E-print Network

- treamento em tempo real de objetos durante o jogo. Diversos experimentos reais s~ao realizados para^amera instalada a uma altura m´inima de 3 metros acima do campo ´e utilizada para capturar imagens do jogo, que s´aticas de jogos. As ac¸~oes no dom´inio s~ao r

Zhang, Richard "Hao"


Innovation on Energy Power Technology (17)Development of EMS/SCADA in TEPCO  

NASA Astrophysics Data System (ADS)

Effective Load Dispatching Automatic Controller (ELDAC) is an EMS/SCADA system for Central Load Dispatching Office in Tokyo Electric Power Company Inc. This paper introduces the progress of development of ELDAC, which forecasts demand, sets up the most efficient generation schedule, and controls total power from generators.

Suzuki, Mamoru


Cramer-Rao lower bound optimization of an EM-CCD-based scintillation gamma camera  

NASA Astrophysics Data System (ADS)

Scintillation gamma cameras based on low-noise electron multiplication (EM-)CCDs can reach high spatial resolutions. For further improvement of these gamma cameras, more insight is needed into how various parameters that characterize these devices influence their performance. Here, we use the Cramer-Rao lower bound (CRLB) to investigate the sensitivity of the energy and spatial resolution of an EM-CCD-based gamma camera to several parameters. The gamma camera setup consists of a 3 mm thick CsI(Tl) scintillator optically coupled by a fiber optic plate to the E2V CCD97 EM-CCD. For this setup, the position and energy of incoming gamma photons are determined with a maximum-likelihood detection algorithm. To serve as the basis for the CRLB calculations, accurate models for the depth-dependent scintillation light distribution are derived and combined with a previously validated statistical response model for the EM-CCD. The sensitivity of the lower bounds for energy and spatial resolution to the EM gain and the depth-of-interaction (DOI) are calculated and compared to experimentally obtained values. Furthermore, calculations of the influence of the number of detected optical photons and noise sources in the image area on the energy and spatial resolution are presented. Trends predicted by CRLB calculations agree with experiments, although experimental values for spatial and energy resolution are typically a factor of 1.5 above the calculated lower bounds. Calculations and experiments both show that an intermediate EM gain setting results in the best possible spatial or energy resolution and that the spatial resolution of the gamma camera degrades rapidly as a function of the DOI. Furthermore, calculations suggest that a large improvement in gamma camera performance is achieved by an increase in the number of detected photons or a reduction of noise in the image area. A large noise reduction, as is possible with a new generation of EM-CCD electronics, may improve the energy and spatial resolution by a factor of 1.5.

Korevaar, Marc A. N.; Goorden, Marlies C.; Beekman, Freek J.



Cramer-Rao lower bound optimization of an EM-CCD-based scintillation gamma camera.  


Scintillation gamma cameras based on low-noise electron multiplication (EM-)CCDs can reach high spatial resolutions. For further improvement of these gamma cameras, more insight is needed into how various parameters that characterize these devices influence their performance. Here, we use the Cramer-Rao lower bound (CRLB) to investigate the sensitivity of the energy and spatial resolution of an EM-CCD-based gamma camera to several parameters. The gamma camera setup consists of a 3 mm thick CsI(Tl) scintillator optically coupled by a fiber optic plate to the E2V CCD97 EM-CCD. For this setup, the position and energy of incoming gamma photons are determined with a maximum-likelihood detection algorithm. To serve as the basis for the CRLB calculations, accurate models for the depth-dependent scintillation light distribution are derived and combined with a previously validated statistical response model for the EM-CCD. The sensitivity of the lower bounds for energy and spatial resolution to the EM gain and the depth-of-interaction (DOI) are calculated and compared to experimentally obtained values. Furthermore, calculations of the influence of the number of detected optical photons and noise sources in the image area on the energy and spatial resolution are presented. Trends predicted by CRLB calculations agree with experiments, although experimental values for spatial and energy resolution are typically a factor of 1.5 above the calculated lower bounds. Calculations and experiments both show that an intermediate EM gain setting results in the best possible spatial or energy resolution and that the spatial resolution of the gamma camera degrades rapidly as a function of the DOI. Furthermore, calculations suggest that a large improvement in gamma camera performance is achieved by an increase in the number of detected photons or a reduction of noise in the image area. A large noise reduction, as is possible with a new generation of EM-CCD electronics, may improve the energy and spatial resolution by a factor of 1.5. PMID:23552717

Korevaar, Marc A N; Goorden, Marlies C; Beekman, Freek J



Final report: Key comparison of 50/60 Hz power SIM.EM-K5  

NASA Astrophysics Data System (ADS)

Under the auspices of the Committee Consultative of Electromagnetism, CCEM, the SIM Electromagnetic Working Group carried out a key comparison of power standards at 50/60 Hz. This key comparison, identified as SIM.EM-K5, aims to provide a link to various NMIs in the SIM region to the CCEM-K5 key comparison on 50/60 Hz power completed in 2001 and piloted by NIST. Measurements in the SIM.EM-K5 comparison were carried out from May 2010 to March 2012, including testing points of active and reactive power. CENAM was the pilot laboratory. Differences between the measurement results of the participating laboratories and the reference value of this key comparison, calculated at each of all the testing points, show a good infrastructure of national standards of measurement of electric power in the SIM region. Based on previous work, a link has been estimated between the results of the CCEM-K5 and the SIM.EM-K5 key comparisons, whose results were reported in 2002 and 2014, respectively. From the link it is shown that the measurement results of SIM.EM-K5 comparison are well supported. The SIM.EM-K5 comparison is a rewording exercise of comparison of the national standards of measurement as recommended by the CIPM. The participating laboratories are fully recommended for their enthusiastic participation in the comparison. Their individual efforts to maintain the national standards of power measurement are acknowledged. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database The final report has been peer-reviewed and approved for publication by the CCEM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

Carranza, R.; Campos, S.; Castruita, A.; Nelson, T.; Ribeiro, A.; So, E.; Di Lillo, L.; Spaggiari, A.; Slomovitz, D.; Izquierdo, Daniel; Faverio, Carlos; Postigo, H.; Díaz, H.; Sanchez, H.; Gonzalez, J.; Zipaquirá Triana, Álvaro



Foreground object detection using top-down information based on EM framework.  


In this paper, we present a novel foreground object detection scheme that integrates the top-down information based on the expectation maximization (EM) framework. In this generalized EM framework, the top-down information is incorporated in an object model. Based on the object model and the state of each target, a foreground model is constructed. This foreground model can augment the foreground detection for the camouflage problem. Thus, an object's state-specific Markov random field (MRF) model is constructed for detection based on the foreground model and the background model. This MRF model depends on the latent variables that describe each object's state. The maximization of the MRF model is the M-step in the EM framework. Besides fusing spatial information, this MRF model can also adjust the contribution of the top-down information for detection. To obtain detection result using this MRF model, sampling importance resampling is used to sample the latent variable and the EM framework refines the detection iteratively. Besides the proposed generalized EM framework, our method does not need any prior information of the moving object, because we use the detection result of moving object to incorporate the domain knowledge of the object shapes into the construction of top-down information. Moreover, in our method, a kernel density estimation (KDE)-Gaussian mixture model (GMM) hybrid model is proposed to construct the probability density function of background and moving object model. For the background model, it has some advantages over GMM- and KDE-based methods. Experimental results demonstrate the capability of our method, particularly in handling the camouflage problem. PMID:22645266

Liu, Zhou; Huang, Kaiqi; Tan, Tieniu



EMS & high reliability organizing. Achieving safety & reliability in the dynamic, high-risk environment.  


Enactment describes how we engage the situation to make sense of it. But by our engagement, we also change the situation. Our presence, alone, will change the situation. At times, we may fail to act. Here, we are at risk of interpreting this as a sense of personal "limitation" in what we can do. This will inhibit us in engaging in other incidents. Rather, we should understand that while we may often fail after engaging, acting is part of performing in uncertainty. In EMS, the system, as it's set up, can lead people to fail to act. For reasons specific to a system, the EMT or paramedic may not act for fear of doing something wrong. This failure to act reinforces the limitations one feels. When you avoid acting, you don't learn. By avoiding testing ourselves, we conclude that constraints exist. This is contrary to the historical approach public safety and EMS personnel use to learn. In the past, it was accepted that we learn what works through action. We also perceive, or sensemake, through interaction with the environment. We watch for responsiveness to our actions, such as cooperation from bystanders vs. defiance. However, this is influenced by how we approach the scene. One EMS provider may obtain cooperation while another experiences defiance. We bracket this information by placing it in context. This interaction is difficult to communicate to those not present at the incident, because they don't know when one "story" begins and when another leaves off. HROs have developed in organizations that adapted to time constraints in uncertain and hazardous environments. There, lessons were actually learned through the blood of live-or-die situations. Academics have codified these principles and concepts that are accessible to EMS caregivers. EMS can benefit from the principles and concepts of HRO through improved performance by individuals and stronger organizations. PMID:24159730

Van Stralen, Daved; Mercer, Thomas A



Fabrication of carbon films with ? 500nm holes for cryo-EM with a direct detector device.  


Single particle electron cryomicroscopy (cryo-EM) is often performed using EM grids coated with a perforated or holey layer of amorphous carbon. Regular arrays of holes enable efficient cryo-EM data collection and several methods for the production of micropatterned holey-carbon film coated grids have been described. However, a new generation of direct detector device (DDD) electron microscope cameras can benefit from hole diameters that are smaller than currently available. Here we extend a previously proposed method involving soft lithography with a poly(dimethylsiloxane) (PDMS) stamp for the production of holey-carbon film coated EM grids. By incorporating electron-beam (e-beam) lithography and modifying the procedure, we are able to produce low-cost high-quality holey-carbon film coated EM grids with ?500nm holes spaced 4?m apart centre-to-centre. We demonstrate that these grids can be used for cryo-EM. Furthermore, we show that by applying image shifts to obtain movies of the carbon regions beside the holes after imaging the holes, the contrast transfer function (CTF) parameters needed for calculation of high-resolution cryo-EM maps with a DDD can be obtained efficiently. PMID:24269484

Marr, Chelsea R; Benlekbir, Samir; Rubinstein, John L



Investigating metal removal potential by Effective Microorganisms (EM) in alginate-immobilized and free-cell forms.  


Metal removal potential of both alginate-immobilized and free-cells of Effective Microorganisms (EM-1™ Inoculant) was investigated in this study. Results revealed that removal of Cr(III), Cu(II) and Pb(II) followed a similar trend where alginate-immobilized EM were more efficient compared to free-cells of EM. For these metals, 0.940, 2.695 and 4.011 mg g(-1) of Cr(III), Cu(II) and Pb(II) were removed compared to only 0.160, 0.859 and 0.755 mg ml(-1) removed by free-cells, respectively. The higher efficiency of alginate-immobilized EM was primarily attributed to the alginate matrix. This was evident when both alginate-immobilized EM and plain alginate beads (without EM), were not significantly different in their removal efficacies. Presence of alginate also enhanced the use of the biosorbents as maximum metal sorption was achieved after 120 min as opposed to only 60 min for free-cells. EM per se in immobilized or free-cell forms did not enhance metal removal efficacy. PMID:24001691

Ting, Adeline Su Yien; Rahman, Nurul Hidayah Abdul; Isa, Mohamed Ikmal Hafiz Mahamad; Tan, Wei Shang



An optically scanned EMS reporting form and analysis system for statewide use: development and five years' experience.  


Analysis of emergency medical services (EMS) systems data is crucial to planning, education, research, and quality assurance programs. Currently, comparative analysis of EMS data between regions or states is virtually impossible due to wide variations in data collection and analysis methods. To devise a practical and uniform EMS reporting system, we referenced the minimum data set (MDS) established by the federal government in 1974 and surveyed 22 states known to be using uniform reporting systems. In developing our final data set, elements were added based on inclusion in the MDS, national survey results, a review of current EMS literature, and consensus of local EMS providers. This set of 48 elements then was incorporated into a reporting form using narrative and optically scanned formats, allowing automated data collection for computer analysis. After a pilot study, the system was improved to allow high-speed ink reading and large volume data storage and analysis using a microcomputer. This system has subsequently been adopted by seven states. The combined data base exceeds 250,000 cases. Error screening algorithms ensure data integrity and are also used for quality assurance. Customized output reports can be generated within minutes and have assisted in EMS quality assurance, planning, and research. We believe that the successful performance of this system supports the use of the suggested data elements as well as optical scanning and microcomputer analysis of EMS data. PMID:1746736

Joyce, S M; Brown, D E



PII: S0301-5629(02)00515-X Original Contribution  

E-print Network

of corneal permeability to glaucoma drugs of different lipophilicity (atenolol, carteolol, timolol and betaxolol). The permeability of rabbit cornea increased by 2.6 times for atenolol, 2.8 for carteolol, 1

Clark, John




... if you are allergic to nebivolol, acebutolol (Sectral), atenolol (Tenormin, in Tenoretic), betaxolol (Kerlone), bisoprolol (Zebeta, in ... Cordarone, Pacerone); beta blockers such as acebutolol (Sectral), atenolol (Tenormin, in Tenoretic), betaxolol (Kerlone), bisoprolol (Zebeta, in ...


Autonomic cardiovascular control in conscious mice ARMIN JUST,1  

E-print Network

) or -adrenergic blockade (atenolol) did not significantly affect the AP spectrum. Atropine reduced HR variability at all frequencies, but this effect waned above 1 Hz. -Adrenergic blockade (atenolol) slightly enhanced

Just, Armin


Neurobiology of Learning and Memory 86 (2006) 249255  

E-print Network

atenolol (0.5 g in 0.2 l) or saline into the BLA together with a subcutaneous injection of either-BLA administration of atenolol selectively blocked this corticosterone-induced memory enhancement. These Wndings

Weinberger, Norman M.


Dolasetron Injection  


... Be sure to mention any of the following: atenolol (Tenormin, in Tenoretic), cimetidine; diuretics ('water pills'); medications ... pressure; medications for irregular heart beat such as atenolol (Tenormin, in Tenoretic), flecainide (Tambocor),quinidine (Quinidex, Quinaglute, ...


Measurement of EM Field Inside a Cruising Aircraft: Potential Problems for the Use of Mobile Phones on Board  

NASA Astrophysics Data System (ADS)

Electromagnetic (EM) emissions from portable electronic devices (PEDs) carried onboard aircraft can interfere with avionic systems. Several onboard systems using EM waves have been planned, such as mobile communications and UWB (ultra-wideband) entertainment services distribution. Manufacturers of this system develop schemes to avoid electromagnetic interference by the transmissions (emissions) of mobile phones with avionic systems; some local-specific problems still remain. The purpose of this chapter is to investigate to what extent non-GSM transmissions from the ground base stations reach inside a cruising aircraft. The EM field at the base station frequency bands is measured in a cruising small aircraft.

Kohmura, A.; Picard, J.; Yonemoto, N.; Yamamoto, K.



SciTech Connect

The U. S. Department of Energy's (DOE) Office of Environmental Management (EM) has the responsibility for cleaning up 60 sites in 22 states that were associated with the legacy of the nation's nuclear weapons program and other research and development activities. These sites are unique and many of the technologies needed to successfully disposition the associated wastes have yet to be developed or would require significant re-engineering to be adapted for future EM cleanup efforts. In 2008, the DOE-EM Engineering and Technology Program (EM-22) released the Engineering and Technology Roadmap in response to Congressional direction and the need to focus on longer term activities required for the completion of the aforementioned cleanup program. One of the strategic initiatives included in the Roadmap was to enhance long term performance monitoring as defined by 'Develop and deploy cost effective long-term strategies and technologies to monitor closure sites (including soil, groundwater, and surface water) with multiple contaminants (organics, metals and radionuclides) to verify integrated long-term cleanup performance'. To support this long-term monitoring (LTM) strategic initiative, EM 22 and the Savannah River National Laboratory (SRNL) organized and held an interactive symposia, known as the 2009 DOE-EM Long-Term Monitoring Technical Forum, to define and prioritize LTM improvement strategies and products that could be realized within a 3 to 5 year investment time frame. This near-term focus on fundamental research would then be used as a foundation for development of applied programs to improve the closure and long-term performance of EM's legacy waste sites. The Technical Forum was held in Atlanta, GA on February 11-12, 2009, and attended by 57 professionals with a focus on identifying those areas of opportunity that would most effectively advance the transition of the current practices to a more effective strategy for the LTM paradigm. The meeting format encompassed three break-out sessions, which focused on needs and opportunities associated with the following LTM technical areas: (1) Performance Monitoring Tools, (2) Systems, and (3) Information Management. The specific objectives of the Technical Forum were to identify: (1) technical targets for reducing EM costs for life-cycle monitoring; (2) cost-effective approaches and tools to support the transition from active to passive remedies at EM waste sites; and (3) specific goals and objectives associated with the lifecycle monitoring initiatives outlined within the Roadmap. The first Breakout Session on LTM performance measurement tools focused on the integration and improvement of LTM performance measurement and monitoring tools that deal with parameters such as ecosystems, boundary conditions, geophysics, remote sensing, biomarkers, ecological indicators and other types of data used in LTM configurations. Although specific tools were discussed, it was recognized that the Breakout Session could not comprehensively discuss all monitoring technologies in the time provided. Attendees provided key references where other organizations have assessed monitoring tools. Three investment sectors were developed in this Breakout Session. The second Breakout Session was on LTM systems. The focus of this session was to identify new and inventive LTM systems addressing the framework for interactive parameters such as infrastructure, sensors, diagnostic features, field screening tools, state of the art characterization monitoring systems/concepts, and ecosystem approaches to site conditions and evolution. LTM systems consist of the combination of data acquisition and management efforts, data processing and analysis efforts and reporting tools. The objective of the LTM systems workgroup was to provide a vision and path towards novel and innovative LTM systems, which should be able to provide relevant, actionable information on system performance in a cost-effective manner. Two investment sectors were developed in this Breakout Session. The last Breakout Session of the Technical Forum

Mayer, J.



Targeting Organic Anion Transporting Polypeptides in Cancer to Improve Diagnostics and Therapy  

E-print Network

Tauroursodeoxycholate Others DPDPE Drugs Acebutolol Rosuvastatin Atenolol Pitavistatin Sotolol Fexofenadine Labetalol Deltorphin II Nadolol Ciprofloxacin Talinolol Gatifloxacin Saquinavir Imatinib Darunavir...

Hays, Amanda Lynne



Compilação de dados atômicos e moleculares do UV ao IV próximo para uso em síntese espectral  

NASA Astrophysics Data System (ADS)

Espectros sintéticos são utéis em uma grande variedade de aplicações, desde análise de abundâncias em espectros estelares de alta resolução ao estudo de populações estelares em espectros integrados. A confiabilidade de um espectro sintético depende do modelo de atmosfera adotado, do código de formação de linhas e da qualidade dos dados atômicos e moleculares que são determinantes no cálculo das opacidades da fotosfera. O nosso grupo no departamento de Astronomia no IAG tem utilizado espectros sintéticos há mais de 15 anos, em