Sample records for atenolol em pacientes

  1. 60 FR 44897 - Drug Export; Atenolol Bulk Drug Substance

    Federal Register 2010, 2011, 2012, 2013, 2014

    1995-08-29

    ...Docket No. 95N-0275] Drug Export; Atenolol Bulk Drug Substance AGENCY: Food...export of the bulk drug substance Atenolol to France to produce various approved finished formulations containing Atenolol alone or in combination....

  2. Atenolol

    MedlinePLUS

    ... organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other ... prevent migraine headaches and to treat alcohol withdrawal, heart failure, and irregular heartbeat. Talk to your doctor about ...

  3. Social Phobia: A Comparison of Behavior Therapy and Atenolol.

    ERIC Educational Resources Information Center

    Turner, Samuel M.; And Others

    1994-01-01

    Randomly assigned 72 social phobics to behavioral (flooding) or drug treatment with atenolol or placebo. Found that flooding consistently was superior to placebo, whereas atenolol was not. Flooding also was superior to atenolol on behavioral measures and composite indexes. Subjects who improved during treatment maintained gains at six-month…

  4. Infrared spectroscopy of racemic and enantiomeric forms of atenolol

    NASA Astrophysics Data System (ADS)

    de Castro, R. A. Esteves; Canotilho, João; Barbosa, Rui M.; Redinha, J. Simões

    2007-08-01

    The molecular structure of conformational isomorphs given by X-ray diffraction for racemic and enantiomeric atenolol were optimized at the HF/6-31G* level of theory and the infrared spectra of the structure were calculated. These spectra are used to characterize the differences between the various atenolol conformers. The spectra of the ( R, S)- and S-atenolol solid forms were recorded and the bands corresponding to the functional groups identified with the aid of the calculated spectra, fitting analysis, temperature effect and H/D isotopic exchange. Particular attention was paid to the stretch vibration modes of the functional groups present in the atenolol.

  5. Apple juice greatly reduces systemic exposure to atenolol

    PubMed Central

    Jeon, Hyewon; Jang, In-Jin; Lee, SeungHwan; Ohashi, Kyoichi; Kotegawa, Tsutomu; Ieiri, Ichiro; Cho, Joo-Youn; Yoon, Seo Hyun; Shin, Sang-Goo; Yu, Kyung-Sang; Lim, Kyoung Soo

    2013-01-01

    AIM Fruit juice reduces the plasma concentrations of several ?-adrenoceptor blockers, likely by inhibiting OATP2B1-mediated intestinal absorption. The aim of this study was to investigate the effects of apple juice on the pharmacokinetics of atenolol. METHODS Twelve healthy Korean volunteers with genotypes of SLCO2B1 c.1457C> T (*1/*1 (n= 6) and *3/*3 (n= 6)) were enrolled in this study. In a three-phase, one-sequence crossover study, the pharmacokinetics (PK) of atenolol was evaluated after administration of 50 mg atenolol. Subjects received atenolol with either 300 ml water, 1200 ml apple juice or 600 ml apple juice. RESULTS Apple juice markedly reduced the systemic exposure to atenolol. The geometric mean ratios (95% confidence intervals) of apple juice : water were 0.18 (0.13, 0.25, 1200 ml) and 0.42 (0.30, 0.59, 600 ml) for the AUC(0,tlast). In this study, the PK parameters of atenolol responded in a dose-dependent manner to apple juice. CONCLUSIONS Apple juice markedly reduced systemic exposure to atenolol. The genetic variation of SLCO2B1 c.1457C>T had a minimal effect on the pharmacokinetics of atenolol when the drug was administered with water or apple juice. PMID:22574741

  6. [Photodegradation of atenolol in aqueous nitrate solution].

    PubMed

    Ji, Yue-Fei; Zeng, Chao; Meng, Cui; Yang, Xi; Gao, Shi-Xiang

    2012-02-01

    The aqueous photolysis of beta-blocker atenolol (ATL) using Xe lamp as simulated solar irradiation source was investigated in the presence of nitrate ions. The effects of nitrate ion concentration, solution pH value, and concentration of bicarbonate and humic substance on the photodegradation of ATL were studied. The results showed that photodegradation of ATL in nitrate solution followed pseudo-first-order kinetics. The increasing concentration of nitrate ion promoted the photodegradation rate of ATL. The first-order rate constant increased from 0.002 26 min(-1) to 0.009 4 min(-1) with nitrate concentration increasing from 0 to 5 mmol x L(-1). Acidic or alkaline condition of the solution favored the photodegradation of ATL. Different concentration of bicarbonate showed insignificant effect of the degradation while the increasing concentration of fulvic acid showed inhibiting effect. Hydroxyl radical was determined to be formed during the photolysis process of ATL using isopropanol as molecular probe. The main photoproducts of ATL were identified by using SPE-LC-MS techniques and possible photoinduced degradation pathways in nitrate solution were proposed. PMID:22509585

  7. Pharmacometabolomics Reveals Racial Differences in Response to Atenolol Treatment

    PubMed Central

    Wikoff, William R.; Frye, Reginald F.; Zhu, Hongjie; Gong, Yan; Boyle, Stephen; Churchill, Erik; Cooper-Dehoff, Rhonda M.; Beitelshees, Amber L.; Chapman, Arlene B.; Fiehn, Oliver; Johnson, Julie A.; Kaddurah-Daouk, Rima

    2013-01-01

    Antihypertensive drugs are among the most commonly prescribed drugs for chronic disease worldwide. The response to antihypertensive drugs varies substantially between individuals and important factors such as race that contribute to this heterogeneity are poorly understood. In this study we use metabolomics, a global biochemical approach to investigate biochemical changes induced by the beta-adrenergic receptor blocker atenolol in Caucasians and African Americans. Plasma from individuals treated with atenolol was collected at baseline (untreated) and after a 9 week treatment period and analyzed using a GC-TOF metabolomics platform. The metabolomic signature of atenolol exposure included saturated (palmitic), monounsaturated (oleic, palmitoleic) and polyunsaturated (arachidonic, linoleic) free fatty acids, which decreased in Caucasians after treatment but were not different in African Americans (p<0.0005, q<0.03). Similarly, the ketone body 3-hydroxybutyrate was significantly decreased in Caucasians by 33% (p<0.0001, q<0.0001) but was unchanged in African Americans. The contribution of genetic variation in genes that encode lipases to the racial differences in atenolol-induced changes in fatty acids was examined. SNP rs9652472 in LIPC was found to be associated with the change in oleic acid in Caucasians (p<0.0005) but not African Americans, whereas the PLA2G4C SNP rs7250148 associated with oleic acid change in African Americans (p<0.0001) but not Caucasians. Together, these data indicate that atenolol-induced changes in the metabolome are dependent on race and genotype. This study represents a first step of a pharmacometabolomic approach to phenotype patients with hypertension and gain mechanistic insights into racial variability in changes that occur with atenolol treatment, which may influence response to the drug. PMID:23536766

  8. Haemodynamic comparison of amlodipine and atenolol in essential hypertension using the quantascope.

    PubMed Central

    Tham, T C; Herity, N; Guy, S; Silke, B

    1993-01-01

    1 We have utilised a non-imaging echo-Doppler cardiac output device, using the principle of attenuated compensation volume flow (ACVF), to assess the cardiovascular effects of amlodipine and atenolol over 3 months in 24 patients with essential hypertension. 2 Both amlodipine and atenolol, at 4 and 12 weeks, similarly reduced mean arterial pressure (12 weeks amlodipine -12.6 mmHg, atenolol -14.9 mmHg; P < 0.01 for each vs baseline). 3 The heart rate fell on atenolol, both at 4 weeks (amlodipine -3 vs atenolol -12 beats min(-1); P < 0.05) and 12 weeks (-1 vs -11 beats min(-1); P < 0.05), without change on amlodipine. 4 Stroke volume initially rose on atenolol without change on amlodipine (4 weeks amlodipine -1.3 ml vs atenolol +10.1 ml; P = 0.05) but between drug effects were not different at 12 weeks. 5 The systemic vascular resistance was reduced on amlodipine (12 weeks: amlodipine -176 dyn s cm(-5): P < 0.05) without change on atenolol (atenolol -48 dyn s cm(-5): NS). 6 The cardiac stroke work was lowered on amlodipine both at 4 weeks (P < 0.01) and 12 weeks (P < 0.05) and statistically different from the unaltered atenolol values at both time points. 7 Skin nutrient flow or fingertip temperature was not altered by either treatment. 8 These results are consistent with contrasting mechanisms of action--vasodilator for amlodipine and decreased cardiac pumping for atenolol. The greater reduction in cardiac stroke work on amlodipine compared with atenolol warrants further investigation during longer-term studies. PMID:12959272

  9. Importance of ancillary properties of beta blockers in angina: a study of celiprolol and atenolol

    Microsoft Academic Search

    J M McLenachan; J T Wilson; H J Dargie

    1988-01-01

    Celiprolol (400 mg) and atenolol (100 mg) were given once a day to 16 patients with stable angina pectoris in a double blind placebo controlled crossover study. Celiprolol produced less suppression of heart rate both at rest and during exercise than atenolol. Both drugs were equally effective in reducing the frequency of angina and in delaying the onset of ischaemia

  10. Effect in bronchial asthma of a new beta-adrenergic blocking drug atenolol (ICI 66, 082)

    Microsoft Academic Search

    N. P. Boye; J. R. Vale

    1977-01-01

    The bronchial effect of intravenous atenolol (ICI 66.082) has been studied in a doubleblind cross over trial in 10 patients with pronounced, labile bronchial asthma. A single i. v. dose of atenolol 3 mg, sufficient to cause a fall in heart rate and systolic blood pressure at rest, induced only a slight and clinically almost negligible impairment of ventilatory function.

  11. Comparison between moexipril and atenolol in obese postmenopausal women with hypertension.

    PubMed

    Stimpel, M; Koch, B; Weber, M A

    1998-09-20

    The present study investigated the effect of the new ACE-inhibitor moexipril versus the beta 1-adrenergic blocker atenolol on metabolic parameters, adverse events (AEs) and sitting systolic (SSBP) and sitting diastolic blood pressure (SDBP) in obese postmenopausal women with hypertension (stage I and II). After a 4-week placebo run-in phase, 116 obese, postmenopausal women with primary hypertension were randomised into two treatment groups receiving once daily dosages of either moexipril 7.5 mg or atenolol 25 mg initially (mean age: 57 +/- 7 years in both groups; mean weight: 94 kg in the moexipril group and 89 kg in the atenolol group, corresponding to a body mass index (BMI) of 35.2 kg/m2 and 34.1 kg/m2 in both groups, respectively). After 4 and 8 weeks, the dosages were uptitrated to moexipril 15 mg, or if necessary to moexipril 15 mg/hydrochlorothiazide (HCTZ) 25 mg, or to atenolol 50 mg and atenolol 50 mg/HCTZ 25 mg, in patients whose blood pressure was not sufficiently controlled. At endpoint, metabolic parameters (total cholesterol, triglycerides, LDL, HDL, glucose, insulin) were not significantly altered in either treatment group. Most frequent adverse events under monotherapy (moexipril/atenolol) were asthenia (5.3/13.0%), headache (13.2/21.7%), cough (7.9/6.5%), pharyngitis (21.1/8.7%) and peripheral oedema (5.3/13.0%). Overall at least one AE was reported in 66% of the patients treated with moexipril and in 78% of those treated with atenolol. Reduction of SSBP/SDBP at endpoint was 14.7 +/- 1.9/10.0 +/- 1.1 and 8.7 +/- 1.9/8.4 +/- 1.1 mmHg after treatment with moexipril and atenolol, respectively. The results showed that moexipril and atenolol are equally effective in reducing blood pressure without adversely affecting blood lipids and carbohydrate metabolism. PMID:9819786

  12. ATENOLOL: PHARMACOKINETIC/DYNAMIC ASPECTS OF COMPARATIVE DEVELOPMENTAL TOXICITY: A REVIEW

    EPA Science Inventory

    Atenolol is a cardioselective B-adrenoreceptor blocking agent, used for treatment of hypertension, including hypertension in pregnancy. Beta-adrenoreceptor antagonists have been impacted in the production of intrauterine growth retardation and considerable range of neonatal probl...

  13. Beneficial Effects of Nebivolol in Comparison with Atenolol on Safety and Tolerability in Essential Hypertension

    PubMed Central

    Inamdar, S.C.; V.B., Karande; S.R., Burute; M.B., Murthy; A., Ghatak

    2014-01-01

    Introduction: Hypertension, “The silent killer” is a multifactorial disorder which is asymptomatic and if left untreated leads to lethal complications. Nebivolol is a third generation beta blocker with additional vasodilating property due to nitric oxide release. Aim: The current study aims to assess efficacy and safety of Nebivolol and compare with Atenolol. Methods: This was prospective, double blind, comparative controlled clinical study. Total 90 patients were enrolled into study as per selection criteria. Patients were randomized to receive Atenolol and Nebivolol with 45 patients in each group for 12 weeks. Results and Conclusion: The mean reduction diastolic blood pressure in Nebivolol and Atenolol group was 10.77±2.60 and 10.05±2.83 respectively. The number of patients with adverse effect events was higher in the Atenolol than in the Nebivolol group (36.84% of Atenolol Vs 12.82% of Nebivolol). Thus it can be concluded that, for the same antihypertensive effect, Nebivolol was better tolerated than Atenolol. PMID:25120998

  14. The sub-lethal effects and tissue concentration of the human pharmaceutical atenolol in rainbow trout (Oncorhynchus mykiss).

    PubMed

    Steinbach, Christoph; Burkina, Viktoriia; Fedorova, Ganna; Grabicova, Katerina; Stara, Alzbeta; Velisek, Josef; Zlabek, Vladimir; Schmidt-Posthaus, Heike; Grabic, Roman; Kocour Kroupova, Hana

    2014-11-01

    Atenolol is a highly prescribed anti-hypertensive pharmaceutical and a member of the group of ?-blockers. It has been detected at concentrations ranging from ng L(-1) to low ?g L(-1) in waste and surface waters. The present study aimed to assess the sub-lethal effects of atenolol on rainbow trout (Oncorhynchus mykiss) and to determine its tissue-specific bioconcentration. Juvenile rainbow trout were exposed for 21 and 42 days to three concentration levels of atenolol (1 ?g L(-1) - environmentally relevant concentration, 10 ?g L(-1), and 1000 ?g L(-1)). The fish exposed to 1 ?g L(-1) atenolol exhibited a higher lactate content in the blood plasma and a reduced haemoglobin content compared with the control. The results show that exposure to atenolol at concentrations greater than or equal to 10 ?g L(-1) significantly reduces both the haematocrit value and the glucose concentration in the blood plasma. The activities of the studied antioxidant enzymes (catalase and superoxide dismutase) were not significantly affected by atenolol exposure, and only the highest tested concentration of atenolol significantly reduced the activity of glutathione reductase. The activities of selected CYP450 enzymes were not affected by atenolol exposure. The histological changes indicate that atenolol has an effect on the vascular system, as evidenced by the observed liver congestion and changes in the pericardium and myocardium. Atenolol was found to have a very low bioconcentration factor (the highest value found was 0.27). The bioconcentration levels followed the order liver>kidney>muscle. The concentration of atenolol in the blood plasma was below the limit of quantification (2.0 ng g(-1)). The bioconcentration factors and the activities of selected CYP450 enzymes suggest that atenolol is not metabolised in the liver and may be excreted unchanged. PMID:25129157

  15. Drugs degrading photocatalytically: Kinetics and mechanisms of ofloxacin and atenolol removal on titania suspensions.

    PubMed

    Hapeshi, E; Achilleos, A; Vasquez, M I; Michael, C; Xekoukoulotakis, N P; Mantzavinos, D; Kassinos, D

    2010-03-01

    The conversion of the antibiotic ofloxacin and the beta-blocker atenolol by means of TiO(2) photocatalysis was investigated. Irradiation was provided by a UVA lamp at 3.37x10(-6)einstein/s photon flux, while emphasis was given on the effect of catalyst type and loading (50-1500mg/L), initial substrate concentration (5-20mg/L), initial pH (3-10) and the effect of H(2)O(2) (0.07-1.4mM) as an additional oxidant on substrate conversion and mineralization in various matrices (i.e. pure water, groundwater and treated municipal effluent). Conversion was assessed measuring sample absorbance at 288 and 224nm for ofloxacin and atenolol, respectively, while mineralization measuring the dissolved organic carbon. Degussa P25 TiO(2) was found to be more active than other TiO(2) samples for either substrate degradation, with ofloxacin being more reactive than atenolol. Conversion generally increased with increasing catalyst loading, decreasing initial substrate concentration and adding H(2)O(2), while the effect of solution pH was substrate-specific. Reaction rates, following a Langmuir-Hinshelwood kinetic expression, were maximized at a catalyst to substrate concentration ratio (w/w) of 50 and 15 for ofloxacin and atenolol, respectively, while higher ratios led to reduced efficiency. Likewise, high concentrations of H(2)O(2) had an adverse effect on reaction, presumably due to excessive oxidant scavenging radicals and other reactive species. The ecotoxicity of ofloxacin and atenolol to freshwater species Daphnia magna was found to increase with increasing substrate concentration (1-10mg/L) and exposure time (24-48h), with atenolol being more toxic than ofloxacin. Photocatalytic treatment eliminated nearly completely toxicity and this was more pronounced for atenolol. PMID:20031189

  16. Atenolol to treat intestinal ischemia and reperfusion in rats.

    PubMed

    Campos, V F; Miranda-Ferreira, R; Taha, N S A; Teixeira, G D; Souza, W T I; Carmo, C E F; Silva-Neto, L A; Gomes, I T; Monteiro, H P; Montero, E F S; Fagundes, D J; Caricati-Neto, A; Taha, M O

    2012-10-01

    To study whether treatment with the beta-blocker atenolol (AT) attenuates intestinal dysfunction caused by ischemia (I) and reperfusion (R), rats were treated with AT (1.5 mg · kg(-1), intravenously) or saline solution (SS) prior to I (60 minutes), which was produced by occlusion of the superior mesenteric artery, and/or R (120 minutes). After I or I/R, 2-cm jejunal segments were mounted in an organ bath to study neurogenic contractions stimulated by electrical pulses or KCl using a digital recording system. Thin jejunal slices were stained with hematoxylin and eosin for optical microscopy analysis. Compared to the sham group, jejunal contractions were similar in the I + AT and the I/R + AT groups, but reduced in the I + SS and the I/R + SS groups. The jejunal enteric nerves were damaged in the I + SS and the I/R + SS groups, but not in the I + AT and the I/R + AT. These results suggest that AT may attenuate intestinal dysfunction caused by I and I/R. PMID:23026582

  17. New alginic acid-atenolol microparticles for inhalatory drug targeting.

    PubMed

    Ceschan, Nazareth Eliana; Bucalá, Verónica; Ramírez-Rigo, María Verónica

    2014-08-01

    The inhalatory route allows drug delivery for local or systemic treatments in a noninvasively way. The current tendency of inhalable systems is oriented to dry powder inhalers due to their advantages in terms of stability and efficiency. In this work, microparticles of atenolol (AT, basic antihypertensive drug) and alginic acid (AA, acid biocompatible polyelectrolyte) were obtained by spray drying. Several formulations, varying the relative composition AT/AA and the total solid content of the atomized dispersions, were tested. The powders were characterized by: Fourier Transform Infrared Spectroscopy, Differential Scanning Calorimetry and Powder X-ray Diffraction, while also the following properties were measured: drug load efficiency, flow properties, particles size and density, moisture content, hygroscopicity and morphology. The ionic interaction between AA and AT was demonstrated, then the new chemical entity could improve the drug targeting to the respiratory membrane and increase its time residence due to the mucoadhesive properties of the AA polymeric chains. Powders exhibited high load efficiencies, low moisture contents, adequate mean aerodynamic diameters and high cumulative fraction of respirable particles (lower than 10 ?m). PMID:24907759

  18. Increased platelet adhesion and aggregation in hypertensive patients: effect of atenolol.

    PubMed Central

    Markel, A; Brook, J G; Levy, Y; Aviram, M; Youdim, M B

    1983-01-01

    Fourteen patients with established hypertension followed a double-blind crossover-styled trial to study the effects of 100 mg/day atenolol compared to placebo. Atenolol was found to be an effective antihypertensive agent, reducing both systolic and diastolic blood pressure. Hypertensive patients appear to have increased in vitro platelet adhesion and aggregation. Atenolol significantly reduced platelet adhesion, but had little effect on aggregation. This may be important in contributing towards the now-recognised cardio-protective effect of the beta-adrenoceptor blocking agents. Blood chemistry and haematological parameters were unchanged; but whereas plasma cholesterol and plasma triglyceride levels remained normal, there was a significant fall in plasma high-density lipoprotein cholesterol levels. Side effects were very few. PMID:6661351

  19. Comparison of once daily atenolol, nitrendipine and their combination in mild to moderate essential hypertension.

    PubMed Central

    Maclean, D; Mitchell, E T; Lewis, R; Irvine, N; McLay, J S; McEwen, J; Coulson, R R; Slater, N D; Fitzsimons, T J; McDevitt, D G

    1990-01-01

    1. The aim of the study was to compare the efficacy and the tolerability of treatment with atenolol (50-100 mg once daily), nitrendipine (20-40 mg once daily) and their combination (atenolol 50 mg + nitrendipine 20 mg) once daily in patients with mild to moderate essential hypertension. 2. The study was a randomised, double-blind, placebo controlled parallel groups design: blood pressures were measured at 'trough' effect (i.e. 24 h after dosing) to assess the adequacy of once-daily treatment. 3. Mean blood pressures (mm Hg) recorded on four occasions over 12 weeks of treatment were significantly lower both with atenolol (155/97 sitting: 155/104 standing) and with the combination of atenolol plus nitrendipine (153/96 sitting: 152/104 standing) than with placebo (169/108 sitting: 169/114 standing). Nitrendipine alone had no significant effect on blood pressure 24 h after dosing (165/104 sitting: 165/110 standing). 4. Withdrawals due to adverse effects were more common during treatment with nitrendipine: 7/32 of the patients experienced adverse effects attributable to intense systemic vasodilatation (e.g., flushing, erythema, headache). 2/37 patients taking atenolol were withdrawn: one because he developed a psoriatic rash and the other because of impaired peripheral circulation. Of the 35 patients taking combination treatment, two were withdrawn: one developed headaches and dyspnoea, and the other asthma. 5. The results suggest that once daily dosing with nitrendipine does not control blood pressure throughout the 24 h period in the majority of patients, and is associated with a considerable burden of adverse effects. Combination treatment was better tolerated but appeared to offer no advantages over atenolol alone in terms either of blood pressure control or adverse effects. PMID:2183868

  20. Simultaneous Determination of Losartan Potassium, Atenolol and Hydrochlorothiazide in Pharmaceutical Preparations by Stability-Indicating UPLC

    Microsoft Academic Search

    D. Durga Rao; N. V. Satyanarayana; S. S. Sait; Y. Ramakoti Reddy; K. Mukkanti

    2009-01-01

    A stability-indicating UPLC method was developed for the simultaneous quantitative determination of losartan potassium, atenolol,\\u000a and hydrochlorothiazide in pharmaceutical dosage forms in the presence of degradation products. The separation was achieved\\u000a on a simple isocratic method (water: acetonitrile: triethyl amine: ortho phosphoric acid (60:40:0.1:0.1, v\\/v) at 0.7 mL min?1, a detection wavelength of 225 nm). The retention times of losartan potassium, atenolol, and

  1. Pharmacokinetics of atenolol enantiomers in humans and rats.

    PubMed

    Mehvar, R; Gross, M E; Kreamer, R N

    1990-10-01

    Single dose pharmacokinetics of atenolol (AT) enantiomers was studied in human volunteers and in rats. After oral administration of 50 mg of racemic AT to humans, the areas under the plasma concentration-time curves (AUCs; mean +/- SD) were 1640 +/- 602 and 1860 +/- 652 (ng/mL)h for the S(-)- and R(+)-enantiomers, respectively (p less than 0.05). The small difference in the AUC was a reflection of a slight, but statistically significant (p less than 0.05) difference in the renal clearance (CLr, mL/min) of the enantiomers [129 +/- 32, S(-)-AT; 120 +/- 29, R(+)-AT]. However, the two enantiomers were not different from each other (p greater than 0.05) with respect to the volume of distribution (V lambda, L/kg) [0.879 +/- 0.342, S(-)-AT; 0.790 +/- 0.255, R(+)-AT] or the terminal elimination rate constant (lambda z, h-1) [0.113 +/- 0.038, S(-)-AT; 0.114 +/- 0.036, R(+)-AT]. After iv administration of 10 mg/kg of the racemic AT to rats, the R(+)-enantiomer achieved higher AUC values [(ng/mL)h] compared with its antipode (p less than 0.05) [3630 +/- 1040, S(-)-AT; 4020 +/- 1080, R(+)-AT]. Similar to the human results, this difference was due to a stereoselective renal clearance (mL/min/kg) in favor of S(-)-AT [14.9 +/- 5.78, S(-)-AT; 13.0 +/- 4.88, R(+)-AT; p less than 0.05].(ABSTRACT TRUNCATED AT 250 WORDS) PMID:2280355

  2. Design, Synthesis, and In Vitro Kinetics Study of Atenolol Prodrugs for the Use in Aqueous Formulations

    PubMed Central

    Qtait, Alaa; Dajani, Khulod Khayyat; Abu Lafi, Saleh

    2014-01-01

    Based on DFT, MP2, and the density functional from Truhlar group (hybrid GGA: MPW1k) calculations for an acid-catalyzed hydrolysis of nine Kirby's N-alkylmaleamic acids and two atenolol prodrugs were designed. The calculations demonstrated that the amide bond cleavage is due to intramolecular nucleophilic catalysis by the adjacent carboxylic acid group and the rate-limiting step is determined based on the nature of the amine leaving group. In addition, a linear correlation of the calculated and experimental rate values has drawn credible basis for designing atenolol prodrugs that are bitterless, are stable in neutral aqueous solutions, and have the potential to release the parent drug in a sustained release manner. For example, based on the calculated B3LYP/6-31 G (d,p) rates, the predicted t1/2 (a time needed for 50% of the prodrug to be converted into drug) values for atenolol prodrugs ProD 1-ProD 2 at pH 2 were 65.3 hours (6.3 hours as calculated by GGA: MPW1K) and 11.8 minutes, respectively. In vitro kinetic study of atenolol prodrug ProD 1 demonstrated that the t1/2 was largely affected by the pH of the medium. The determined t1/2 values in 1N HCl, buffer pH 2, and buffer pH 5 were 2.53, 3.82, and 133 hours, respectively. PMID:24526887

  3. Recurrence of atrial fibrillation after switching from brand to generic atenolol.

    PubMed

    Gallelli, Luca; Maida, Francesca; Staltari, Orietta; Rende, Pierandrea; Russo, Emilio; Caroleo, Benedetto; De Sarro, Giovambattista

    2015-01-01

    Beta blockers are the initial treatment for rate control of supraventricular tachyarrhythmia in patients without a history of myocardial infarction or left ventricular dysfunction. In this article we report the recurrence of atrial fibrillation after switching to the generic formulation of atenolol. PMID:25709353

  4. Recurrence of atrial fibrillation after switching from brand to generic atenolol

    PubMed Central

    Gallelli, Luca; Maida, Francesca; Staltari, Orietta; Rende, Pierandrea; Russo, Emilio; Caroleo, Benedetto; De Sarro, Giovambattista

    2015-01-01

    Beta blockers are the initial treatment for rate control of supraventricular tachyarrhythmia in patients without a history of myocardial infarction or left ventricular dysfunction. In this article we report the recurrence of atrial fibrillation after switching to the generic formulation of atenolol. PMID:25709353

  5. ADVERSE PRE- AND POSTNATAL EVENTS REPORTED TO FDA IN ASSOCIATION WITH MATERNAL ATENOLOL TREATMENT IN PREGNANCY

    EPA Science Inventory

    Atenolol is a beta-adrenoreceptor blocker used for treatment of hypertension in pregnancy. This study evaluates the reporting frequency of adverse pre- and postnatal outcomes in a series of 70 cases of maternal exposure during gestation, derived from 140 reports to FDA with Ateno...

  6. Treatment of angina pectoris with nifedipine and atenolol: efficacy and effect on cardiac function.

    PubMed Central

    Findlay, I N; MacLeod, K; Ford, M; Gillen, G; Elliott, A T; Dargie, H J

    1986-01-01

    The antianginal effects of nifedipine 20 mg three times a day and atenolol 100 mg once a day singly and in combination were investigated in 16 patients with angina pectoris. The amount of work that could be done before angina and ST depression appeared was significantly increased by atenolol and the combination but not by nifedipine. At peak exercise the number of leads on a 16 point precordial electrocardiogram map that demonstrated greater than or equal to 1 mm ST segment depression was significantly reduced from a mean (SD) of 5.0 (0.4) on placebo to 3.7 (0.6), 2.8 (0.4), and 2.3 (0.7) on nifedipine, atenolol, and the combination respectively. Mean resting left ventricular ejection fraction, assessed by gated radionuclide ventriculography, did not change during any active treatment phase but increased significantly during exercise only on nifedipine and the combination. The nifedipine/atenolol combination was the most effective treatment, and the data suggest that nifedipine may be used to best advantage in combination with a beta blocker. PMID:3082344

  7. Effects of atenolol and losartan on baroreflex sensitivity and heart rate variability in uncomplicated essential hypertension.

    PubMed

    Chern, Chang-Ming; Hsu, Hung-Yi; Hu, Han-Hwa; Chen, Yen-Yu; Hsu, Li-Chi; Chao, A-Ching

    2006-02-01

    Baroreflex sensitivity (BRS) and heart rate variability (HRV) are potential therapeutic targets. The present study was conducted to assess changes in BRS and HRV after monotherapy with losartan versus that of atenolol in uncomplicated essential hypertension. Thirty subjects with uncomplicated essential hypertension were randomized to receive atenolol 50 mg to 100 mg (n = 15) or losartan 50 mg to 100 mg (N = 15) daily for 6 months. Instantaneous systolic blood pressure (SBP) and heart rate were assessed using servo-controlled infrared finger plethysmography before treatment and at the end of 3 months and 6 months after treatment. The fluctuation in SBP and interpulse interval (IPI) was divided into three specific frequency ranges by fast Fourier transform as high frequency (HF; 0.15 Hz-0.4 Hz), low frequency (LF; 0.04 Hz-0.15 Hz), and very low frequency (VLF; 0.004 Hz-0.04 Hz). The BRS was expressed as (1) SBP-IPI transfer function with its magnitude in the HF and LF ranges and (2) BRS index alpha. The HRV was expressed as total power and power in the LF and HF ranges of interpulse interval. Blood pressure was reduced to a similar extent in both groups. Compared with the baseline, BRS did not improve in both groups at month 3. However, BRS was significantly improved in the losartan group (P < 0.05) but not in the atenolol group at month 6. In addition, BRS was significantly higher in the losartan group than the atenolol group at month 3 and month 6 (P < 0.05). Moreover, heart rate variability was significantly reduced in the atenolol group at month 6 (P < 0.05), but not in the losartan group. The HRV in the losartan group was significantly higher than that in the atenolol group at month 6 (P < 0.05). These findings suggest superior effects of losartan on BRS and HRV than atenolol in uncomplicated essential hypertension, which may be beyond blood pressure reduction/resetting. PMID:16495752

  8. Comparison of nebivolol and atenolol on blood pressure, blood sugar, and lipid profile in patients of essential hypertension

    PubMed Central

    Badar, V.A.; Hiware, Sachin K.; Shrivastava, Meena P.; Thawani, V.R.; Hardas, M.M.

    2011-01-01

    Background: Nebivolol is a third-generation ?-blocker, with highest ?1 selectivity and nitric-oxide-derived vasodilatation. It also exhibits antiproliferative and antioxidant property that has beneficial metabolic profile compared to second-generation ? blockers like atenolol. This study was planned to study the comparative effects of nebivolol and atenolol on metabolic parameters in patients with essential hypertension. Materials and Methods: A prospective, randomized, parallel, open-label clinical study was carried out on patients with essential hypertension. The patients were randomly assigned to receive tablet atenolol (Group A) and nebivolol (Group B) for a period of 24 weeks. Investigations were carried out at baseline and at the end of study period, that is, 24 weeks. Out of 69 patients, 60 completed the study and the data was analyzed using student's t-test. P < 0.05 was considered statistically significant. Results: Atenolol and nebivolol both showed significant (P < 0.001) antihypertensive action after 24 weeks. Mean blood sugar and lipid profile were found to be significantly (P < 0.001) elevated after 24 weeks of treatment with atenolol but not with nebivolol. Heart rate was significantly (P < 0.001) decreased in both groups at 24 weeks. Conclusion: In view of metabolic adverse effects of atenolol, nebivolol is the better choice whenever ?-blockers have to be used in essential hypertension. PMID:21845001

  9. Effect of atenolol and celiprolol on acetylcholine-induced coronary vasomotion in coronary artery disease

    Microsoft Academic Search

    Wolfram Burger; Christian Hampel; Martin Kaltenbach; Andreas Hartmann; Manfred Herrmann; Josef A Hoffmann; Harald Klepzig

    2000-01-01

    Earlier studies have reported on the potentiated muscarinic vasoconstriction of intracoronary acetylcholine after metoprolol application in patients with coronary artery disease. The present study investigated the effect of celiprolol, atenolol, and placebo on acetylcholine-induced vasomotion in patients with coronary artery disease. Furthermore, direct effects on coronary vasomotion and on hemodynamics were evaluated. Acetylcholine (intracoronary concentrations of 6.3 × 10?7, 2.0

  10. Randomised trial comparing propranolol with atenolol in immediate treatment of suspected myocardial infarction

    Microsoft Academic Search

    R G Wilcox; J M Roland; D C Banks; J R Hampton; J R Mitchell

    1980-01-01

    The value of beta-blockade for suspected acute myocardial infarction was assessed by determining the six-week and one-year mortality rates in patients started on propranolol, atenolol, or placebo immediately on entry to a coronary care unit. A total of 388 patients entered this double-blind, randomised study, and when analysed on the basis of the initial, intention-to-treat categories there was no significant

  11. Efficacy and tolerability of losartan potassium and atenolol in patients with mild to moderate essential hypertension

    Microsoft Academic Search

    Bjorn Dahlöf; Susan E. Keller; Lukas Makris; Allan I. Goldberg; Charles S. Sweet; Nicholas Y. Lim

    1995-01-01

    The objective of this study was to compare the antihypertensive efficacy and tolerability of losartan potassium (losartan) and atenolol in patients with mild-to-moderate essential hypertension. This was a multinational, prospective, randomized, 12-week double-blind parallel study with a follow-up of 4 to 10 days posttreatment to assess any adverse effects of abrupt therapy withdrawal.Two hundred two patients were randomized (2: 1)

  12. Change in mRNA Expression after Atenolol, a Beta-adrenergic Receptor Antagonist and Association with Pharmacological Response

    PubMed Central

    Kohli, Utkarsh; Grayson, Britney L; Aune, Thomas M; Ghimire, Laxmi V; Kurnik, Daniel; Stein, C Michael

    2009-01-01

    Aims Genetic determinants of variability in response to ?-blockers are poorly characterized. We defined changes in mRNA expression after a ?-blocker to identify novel genes that could affect response and correlated these with inhibition of exercise-induced tachycardia, a measure of ?-blocker sensitivity. Methods Nine subjects exercised before and after a single oral dose of 25mg atenolol and mRNA gene expression was measured using an Affymetrix GeneChip Human Gene 1.0 ST Array. The area under the heart rate-exercise intensity curve (AUC) was calculated for each subject; the difference between post- and pre-atenolol AUCs (? AUC), a measure of ?-blocker response, was correlated with the fold-change in mRNA expression of the genes that changed more than 1.3-fold. Results Fifty genes showed more than 1.3-fold increase in expression; 9 of these reached statistical significance (P < 0.05). Thirty-six genes had more than 1.3-fold decrease in expression after atenolol; 6 of these reached statistical significance (P < 0.05). Change in mRNA expression of FGFBP2 and Probeset ID 8118979 was significantly correlated with atenolol response (P = 0.03 and 0.02, respectively). Conclusion The expression of several genes not previously identified as part of the adrenergic signaling pathway changed in response to a single oral dose of atenolol. Variation in these genes could contribute to unexplained differences in response to ?-blockers. PMID:19915711

  13. A double blind placebo controlled comparison of verapamil, atenolol, and their combination in patients with chronic stable angina pectoris.

    PubMed Central

    Findlay, I N; MacLeod, K; Gillen, G; Elliott, A T; Aitchison, T; Dargie, H J

    1987-01-01

    The efficacy and effect on cardiac function of verapamil 120 mg three times a day and atenolol 100 mg once a day, singly and in combination, were evaluated in 15 patients with angina pectoris. While they were on the combination treatment four patients withdrew from the study. Episodes of angina pectoris and glyceryl trinitrate consumption were significantly reduced only on the combination. On the combination only four patients developed evidence of ischaemia during exercise compared with seven on verapamil and ten on atenolol. ST segment depression at peak exercise, assessed by 16 point precordial mapping, was reduced by all active treatments from 7.1 on placebo to 2.7, 0.9, and 0.6 mm on atenolol, verapamil, and the combination respectively. Mean left ventricular ejection fraction fell significantly from 60% on placebo to 53% on the combination but was unchanged on verapamil and atenolol. Verapamil was an effective alternative to atenolol; the combination was the most effective treatment but was associated with a significant morbidity. PMID:3555566

  14. Study of polymorphism of Atenolol and Captopril antihypertensives using x-ray powder diffraction and Rietveld refinement

    NASA Astrophysics Data System (ADS)

    Sato, Juliana; Ferreira, Fabio

    2013-03-01

    Characterization of bulk drugs has become increasingly important in the pharmaceutical industry. X-ray powder diffractometry is an effective technique for the identification of crystalline solid-phase drugs. The technique is unique, since it combines specificity with a high degree of accuracy for the characterization of pharmaceuticals in solid state and is an especially useful method to describe the possible polymorphic behavior of drugs substances. In this work X-ray diffraction data have been obtained for two well-known antihypertensive drugs currently being administered in tablet form. They include atenolol and captopril. Atenolol and captopril were purchased from drugstore. The characterizations of the atenolol and captopril samples were carried out by FTIR spectroscopy and X-ray powder diffraction (XRPD).

  15. Nebivolol induces distinct changes in profibrosis microRNA expression compared with atenolol, in salt-sensitive hypertensive rats.

    PubMed

    Ye, Hongmei; Ling, Shukuan; Castillo, Alexander C; Thomas, Bejoy; Long, Bo; Qian, Jinqiao; Perez-Polo, Jose R; Ye, Yumei; Chen, Xiaoping; Birnbaum, Yochai

    2013-05-01

    Nebivolol is a selective ?1-blocker with nitric oxide-enhancing effects. MicroRNAs are small noncoding RNA molecules that downregulate gene expression. We compared the effects of nebivolol and atenolol, a first generation ?1-selective blocker, on left ventricular hypertrophy, fibrosis, and function and microRNA expression in a rodent model of hypertension. Dahl salt-sensitive rats received either low-salt chow (control) or AIN-76A high-salt (8% NaCl) diet and randomized to vehicle (high-salt), nebivolol (20 mg/kg per day), or atenolol (50 mg/kg per day) for 8 weeks. High-salt induced left ventricular hypertrophy and fibrosis and decreased the expression of miR-27a, -29a, and -133a. Nebovolol attenuated deterioration of left ventricular systolic function, remodeling, and fibrosis more than atenolol, despite similar effects on heart rate and blood pressure. Nebivolol, but not atenolol, prevented the decrease in miR-27a and -29a induced by high-salt. Nebivolol and atenolol equally attenuated the decrease in miR-133a. In vitro overexpression of miR-27a,-29a, and -133a inhibited cardiomyocyte hypertrophy and reduced collagen expression. Both miR-27a and -29a target Sp1, and miR-133a targets Cdc42. Pharmacological inhibition of Sp1 and Cdc42 decreased myocardial fibrosis and hypertrophy. Our data support a differential microRNAs expression profile in salt-induced hypertension. Nebivolol substantially attenuated cardiac remodeling, hypertrophy, and fibrosis more than atenolol. These effects are related to attenuation of the hypertension-induced decrease in miR-27a and -29a (with a subsequent decrease in Sp1 expression) and miR-133a (with a subsequent decrease in Cdc42). PMID:23460283

  16. Ecotoxicity of ketoprofen, diclofenac, atenolol and their photolysis byproducts in zebrafish (Danio rerio).

    PubMed

    Diniz, M S; Salgado, R; Pereira, V J; Carvalho, G; Oehmen, A; Reis, M A M; Noronha, J P

    2015-02-01

    The occurrence of pharmaceutical compounds in wastewater treatment plants and surface waters has been detected worldwide, constituting a potential risk for aquatic ecosystems. Adult zebrafish, of both sexes, were exposed to three common pharmaceutical compounds (atenolol, ketoprofen and diclofenac) and their UV photolysis by-products over seven days. The results show that diclofenac was removed to concentrationsatenolol and ketoprofen was reduced after the parent compounds were transformed by photolysis, whereas the toxicity increased significantly from the by-products generated through diclofenac photolysis. Therefore, diclofenac photolysis would possibly necessitate higher irradiation time to ensure that the associated by-products are completely degraded to harmless form(s). PMID:25461029

  17. Photochemical degradation of atenolol, carbamazepine, meprobamate, phenytoin and primidone in wastewater effluents.

    PubMed

    Dong, Mei Mei; Trenholm, Rebecca; Rosario-Ortiz, Fernando L

    2015-01-23

    The photochemical degradation of five pharmaceuticals was examined in two secondary wastewater effluents. The compounds, which included atenolol, carbamazepine, meprobamate, phenytoin and primidone, were evaluated for both direct and sensitized photolysis. In the two wastewaters, direct photolysis did not lead to significant compound degradation; however, sensitized photolysis was an important removal pathway for the five pharmaceuticals. Upon solar irradiation, hydroxyl radical (HO) was quantified using the hydroxylation of benzene and singlet oxygen ((1)O2) formation was monitored following the degradation of furfuryl alcohol. Degradation via sensitized photolysis was observed following five-day exposures for atenolol (69-91%), carbamazepine (67-98%), meprobamate (16-52%), phenytoin (44-85%), and primidone (34-88%). Varying removal is likely a result of the differences in reactivity with transient oxidants. Averaged steady state HO concentrations ranged from 1.2 to 4.0×10(-16)M, whereas the concentrations of (1)O2 were 6.0-7.6×10(-14)M. Partial removal due to presence of HO indicates it was not the major sink for most compounds examined. Other transient oxidants, such as (1)O2 and triplet state effluent organic matter, are likely to play important roles in fates of these compounds. PMID:24798495

  18. Spectral and mechanistic investigations of ruthenium(III) catalyzed oxidation of atenolol by diperiodatocuprate(III) in aqueous alkaline medium

    NASA Astrophysics Data System (ADS)

    Patil, R. K.; Nandibewoor, S. T.; Chimatadar, S. A.

    2012-03-01

    The kinetics of ruthenium(III) catalyzed oxidation of atenolol by diperiodatocuprate(III) in aqueous alkaline medium at a constant ionic strength of I = 0.10 M has been studied spectrophotometrically at 27°C. The reaction between diperiodatocuprate(III) and atenolol in alkaline medium in presence of ruthenium(III) exhibits 2: 1 stoichiometry (atenolol: diperiodatocuprate(III)). The main products were identified by spot test, IR, NMR, and LC-MS. The reaction is of first order in DPC concentrations and has less than unit order in both ATN and alkali concentrations. The order in ruthenium(III) was unity. Intervention of free radicals was observed in the reaction. Increase in periodate concentration decreases the rate. The oxidation reaction in alkaline medium has been shown to proceed via a ruthenium(III)-atenolol complex, which reacts with monoperiodatocuprate(III) in a rate determining step followed by other fast steps to give the products. Probable mechanism is proposed and discussed. The activation parameters with respect to the slow step of the mechanism and thermodynamic quantities were determined and discussed.

  19. Use of ratings of perceived exertion for predicting maximal work rate and prescribing exercise intensity in patients taking atenolol

    Microsoft Academic Search

    R G Eston; M Thompson

    1997-01-01

    OBJECTIVE: The purpose of this study was to assess the efficacy of Borg's rating of perceived exertion (RPE) scale to predict maximal exercise levels to control exercise intensity in patients taking atenolol for the treatment of essential hypertension. Normally, a standard formula (220-age) is used for calculating a percentage of exercise intensity, but beta blockade can cause reductions in maximal

  20. The effect of hydrophilic and lipophilic polymers and fillers on the release rate of atenolol from HPMC matrices

    Microsoft Academic Search

    F. Lotfipour; A. Nokhodchi; M. Saeedi; S. Norouzi-Sani; J. Sharbafi; M. R. Siahi-Shadbad

    2004-01-01

    The objective of this study is to investigate the effect of various polymers, and fillers, and their concentrations on the release rate of atenolol from polymeric matrices. Four polymers namely hydroxypropylmethylcellulose (HPMC), Eudragit RSPO, ethylcellulose (EC) and sodium carboxymethylcellulose (NaCMC) were used. The dissolution profiles showed that an increase in the concentration of HPMC and EC resulted in a reduction

  1. Spectroscopic and DFT study of atenolol and metoprolol and their copper complexes

    NASA Astrophysics Data System (ADS)

    Cozar, O.; Szabó, L.; Cozar, I. B.; Leopold, N.; David, L.; C?inap, C.; Chi?, V.

    2011-05-01

    IR, Raman and surface-enhanced Raman scattering (SERS) spectra of atenolol (ATE) and metoprolol (MET) were recorded and assigned on the basis of density functional theory (DFT) calculations. A reliable assignment of vibrational IR and Raman bands of the two compounds was possible by a proper choice of models used in quantum chemical calculations. Both molecules are adsorbed to the silver surface mainly through the oxygen atoms and ?-electrons of the phenyl ring. The coordination mode of the metal ions in Cu(II)-ATE and -MET compounds was also derived from IR and EPR spectra. EPR spectra give evidence for a square-planar arrangement around the copper (II) ion in the case of Cu-ATE complex, with a N 2O 2 chromophore. Only oxygen atoms are involved in the cooper coordination for Cu-MET complex, and two types of local symmetries with d and d as ground states for paramagnetic electron coexist.

  2. Simultaneous spectrophotometric estimation of Hydrochlorothiazide, Atenolol and Losartan potassium in tablet dosage form.

    PubMed

    Thomas, Asha B; Chavan, Umesh B; Nanda, Rabindra K; Kothapalli, Lata P; Deshpande, Avinash D; Jagdale, Sheetal N; Dighe, Shweta B

    2009-01-01

    Two simple, accurate and reproducible spectrophotometric methods have been developed for the simultaneous estimation of Hydrochlorothiazide (Hctz), Atenolol (Atn) and Losartan potassium (Los) in combined tablet dosage forms. The first method involves determination using the simultaneous equation method, the sampling wavelengths selected are, 272.5 nm, 224 nm and 250 nm over the concentration ranges of 0.5-30 microg/ml, 1-50 microg/ ml and 1-60 microg/ml for Hctz, Atn and Los respectively. The second method is the First order derivative method, the sampling wavelengths selected for estimation of Hctz, Atn and Los are 280.5 nm, 233 nm and 244 nm with linearity in the concentration ranges of 0.5-30 microg/ ml, 1-50 microg/ml and 1-60 microg/ml respectively. The results of the analysis were validated statistically and recovery studies were carried out as per ICH guidelines. PMID:21268558

  3. Spectroscopic investigations and crystal structure from synchrotron powder data of the inclusion complex of ?-cyclodextrin with atenolol

    NASA Astrophysics Data System (ADS)

    Borodi, Gheorghe; Bratu, Ioan; Dragan, Felicia; Peschar, René; Helmholdt, Robert B.; Hernanz, Antonio

    2008-10-01

    Inclusion complexes of atenolol with ?-cyclodextrin (?-CD) in aqueous solution have been investigated with 1H NMR and UV-vis spectroscopy. The stoichiometry of this inclusion complex was established to be equimolar (1:1) and its stability constant was determined by UV-vis spectroscopy. The crystal structure of the ?-CD-atenolol (1:1) inclusion compound has been solved from synchrotron powder diffraction data using direct-space search techniques. The crystal structure model and 1H NMR data are in good agreement and, with support of Hyperchem MM+ molecular dynamics results, suggest which protons are likely to be involved in the inclusion process that leads to the supramolecular architecture of this guest-host complex.

  4. Electrochemical investigation of atenolol oxidation and detection by using a multicomponent nanostructural assembly of amino acids and gold nanoparticles

    NASA Astrophysics Data System (ADS)

    Pruneanu, Stela; Pogacean, Florina; Grosan, Camelia; Pica, Elena Maria; Bolundut, Liviu Calin; Biris, Alexandru Sorin

    2011-02-01

    A novel nanostructured assembly based on poly(glutamic) acid/cysteine/gold nanoparticles was designed to modify the surface of a glassy carbon electrode (GCE) and used to study the atenolol oxidation. The GCE surface was initially covered by poly(glutamic) acid/cysteine layers followed by covalent attachment of citrate-capped 40 nm-AuNPs. The system excellent electrochemical performance was tested by Linear Sweep Voltammetry and Electrochemical Impedance Spectroscopy and allowed the detection of an atenolol oxidation peak (around +0.65 V/SCE) with a detection limit of 3.9 × 10-7 M. Such findings could be incorporated in highly sensitive detection technologies of various biological or chemical compounds and molecules.

  5. Comparative effects of celiprolol, propranolol, oxprenolol, and atenolol on respiratory function in hypertensive patients with chronic obstructive lung disease

    Microsoft Academic Search

    Roberto Fogari; Annalisa Zoppi; Franco Tettamanti; Luigi Poletti; Giancarlo Rizzardi; Giorgio Fiocchi

    1990-01-01

    Summary The aim of the study was to compare the pulmonary effects of four beta-blockers with different ancillary properties: propranolol (non-beta1 selective without ISA), oxprenolol (non-beta1 selective with ISA), atenolol (beta1 selective), and celipropol (beta1 selective with mild beta2-agonist and alpha2-antagonist activity) in hypertensive patients with chronic obstructive lung disease. Ten asthmatic patients, all males, aged 50–66 years were studied.

  6. Twenty-four hour effects of oxprenolol oros and atenolol on heart rate, blood pressure, exercise tolerance and perceived exertion

    Microsoft Academic Search

    M. A. van Baak; F. T. J. Verstappen; B. Oosterhuis

    1986-01-01

    The effects of oxprenolol, a non-selective beta-blocker with moderate intrinsic sympathomimetic activity (ISA), given by the Oros delivery system, on resting and exercise heart rate and blood pressure have been compared over a 24-h period with those of atenolol, a beta1-selective blocker without ISA. The effects on maximal and submaximal exercise tolerance and perceived exertion were studied in relation to

  7. Long-Term Efficacy of Atenolol for Atrioventricular Reciprocating Tachycardia in Children Less Than 5 Years Old

    Microsoft Academic Search

    J. K. Ko; J. E. Ban; Y. H. Kim; I. S. Park

    2004-01-01

    Atrioventricular reciprocating tachycardia (AVRT) using an accessory pathway is the most common supraventricular tachycardia observed in infancy and childhood. There is a general agreement to treat children older than 5 years who are on a potentially long-term antiarrhythmic agent with radiofrequency catheter ablation. Atenolol, a relatively long-acting and cardioselective ß-adrenoceptor blocker, has been used to control the various types of

  8. A Stability-indicating High Performance Liquid Chromatographic Assay for the Simultaneous Determination of Atenolol and Lercanidipine Hydrochloride in Tablets.

    PubMed

    Kaila, H O; Ambasana, M A; Thakkar, R S; Saravaia, H T; Shah, A K

    2011-07-01

    A simple, rapid, precise and accurate isocratic reversed phase stability indicating HPLC method was developed and validated for the simultaneous determination of atenolol and lercanidipine hydrochloride in commercial tablets. The chromatographic separation was achieved on phenomenex Gemini C18 (250×4.6 mm, 5 ?m) column using a mobile phase consisting of acetonitrile and buffer (20 mM potassium dihydrogen phosphate pH 3.5) in the ratio of (55:45, v/v) at a flow rate of 1.0 ml/min and UV detection at 235 nm. The linearity of the proposed method was investigated in the range of 40-160 ?g/ml (r(2)=0.9995) for atenolol and 8-32 ?g/ml (r(2)=0.9993) for lercanidipine. Degradation products produced as a result of stress studies did not interfere with the detection of atenolol and lercanidipine and the assay can thus be considered stability-indicating. PMID:22707819

  9. Environmental risk assessment of human pharmaceuticals in the European Union: A case study with the ?-blocker atenolol.

    PubMed

    Küster, Anette; Alder, Alfredo C; Escher, Beate I; Duis, Karen; Fenner, Kathrin; Garric, Jeanne; Hutchinson, Thomas H; Lapen, David R; Péry, Alexandre; Römbke, Jörg; Snape, Jason; Ternes, Thomas; Topp, Ed; Wehrhan, Anne; Knacker, Thomas

    2010-07-01

    ?-Adrenergic receptor blockers (?-blockers) are applied to treat high blood pressure, ischemic heart disease, and heart rhythm disturbances. Due to their widespread use and limited human metabolism, ?-blockers are widely detected in sewage effluents and surface waters. ?-Adrenergic receptors have been characterized in fish and other aquatic animals, so it can be expected that physiological processes regulated by these receptors in wild animals may be affected by the presence of ?-blockers. Because ecotoxicological data on ?-blockers are scarce, it was decided to choose the ?-blocker atenolol as a case study pharmaceutical within the project ERAPharm. A starting point for the assessment of potential environmental risks was the European guideline on the environmental risk assessment of medicinal products for human use. In Phase I of the risk assessment, the initial predicted environmental concentration (PEC) of atenolol in surface water (500?ng L?1) exceeded the action limit of 10?ng L?1. Thus, a Phase II risk assessment was conducted showing acceptable risks for surface water, for groundwater, and for aquatic microorganisms. Furthermore, atenolol showed a low potential for bioaccumulation as indicated by its low lipophilicity (log KOW?=?0.16), a low potential for exposure of the terrestrial compartment via sludge (log KOC?=?2.17), and a low affinity for sorption to the sediment. Thus, the risk assessment according to Phase II-Tier A did not reveal any unacceptable risk for atenolol. Beyond the requirements of the guideline, additional data on effects and fate were generated within ERAPharm. A 2-generation reproduction test with the waterflea Daphnia magna resulted in the most sensitive no-observed-effect concentration (NOEC) of 1.8?mg L?1. However, even with this NOEC, a risk quotient of 0.003 was calculated, which is still well below the risk threshold limit of 1. Additional studies confirm the outcome of the environmental risk assessment according to EMEA/CHMP (2006). However, atenolol should not be considered as representative for other ?-blockers, such as metoprolol, oxprenolol, and propranolol, some of which show significantly different physicochemical characteristics and varying toxicological profiles in mammalian studies. PMID:19886730

  10. Polymers derived from Xanthomonas campesteris and Cyamopsis tetragonolobus used as retardant materials for the formulation of sustained release floating matrix tablet of atenolol.

    PubMed

    Dey, Sanjay; Mazumder, Bhaskar; Chattopadhyay, Sankha; Das, Malay Kanti; Sinha, Samarendu; Ganguly, Shantanu; De, Kakali; Mishra, Mridula

    2014-04-01

    The objective of the present study was to develop, optimize, in vitro, and in vivo evaluation of floating matrix tablet of atenolol using polymer blend derived from Xanthomonas campesteris and Cyamopsis tetragonolobus that are characterized by release requirements of sustained-release product and to improve the oral bioavailability of the drug. A 3(2) full factorial design was employed to optimize the tablets, where content of polymer blend (X1) and ratio of xanthan gum-to-guar gum (X2) were considered as independent variables. The effects of independent variables on dependent variables, i.e. floating time, diffusion exponent, and time to release 50% of atenolol were evaluated. The in vivo pharmacokinetic parameters of the optimized formulation were compared with the marketed sustained release formulation of atenolol (Aten(®)). The optimized formulation containing 20% (w/w) of polymer blend and 50:50 ratio of xanthan gum-to-guar gum was able to float more than 12h and showed the desired sustained drug release from the tablets. In vivo retention studies in rabbit stomach showed the gastric residence of tablet up to 6h. The in vivo study of optimized tablets illustrated significant improvement in the oral bioavailability of atenolol in rabbits. It can be concluded that floating matrix tablet of atenolol prepared by using xanthan gum and guar gum has potential for sustained release of the drug as well as improved oral bioavailability through enhanced gastric residence time of formulation in stomach. PMID:24472506

  11. Formulation and Evaluation of Fixed-Dose Combination of Bilayer Gastroretentive Matrix Tablet Containing Atorvastatin as Fast-Release and Atenolol as Sustained-Release

    PubMed Central

    Dey, Sanjay; Chattopadhyay, Sankha; Mazumder, Bhaskar

    2014-01-01

    The objective of the present study was to develop bilayer tablets of atorvastatin and atenolol that are characterized by initial fast-release of atorvastatin in the stomach and comply with the release requirements of sustained-release of atenolol. An amorphous, solvent evaporation inclusion complex of atorvastatin with ?-cyclodextrin, present in 1?:?3 (drug/cyclodextrin) molar ratio, was employed in the fast-release layer to enhance the dissolution of atorvastatin. Xanthan gum and guar gum were integrated in the sustained-release layer. Bilayer tablets composed of sustained-release layer (10% w/w of xanthan gum and guar gum) and fast-release layer [1?:?3 (drug/cyclodextrin)] showed the desired release profile. The atorvastatin contained in the fast-release layer showed an initial fast-release of more than 60% of its drug content within 2?h, followed by sustained release of the atenolol for a period of 12?h. The pharmacokinetic study illustrated that the fast absorption and increased oral bioavailability of atorvastatin as well as therapeutic concentration of atenolol in blood were made available through adoption of formulation strategy of bilayer tablets. It can be concluded that the bilayer tablets of atorvastatin and atenolol can be successfully employed for the treatment of hypertension and hypercholesterolemia together through oral administration of single tablet. PMID:24527446

  12. Development and in vitro permeation studies of proniosomal based transdermal delivery system of Atenolol.

    PubMed

    Ramkanth, Sundarapandian; Chetty, Challa Madhusudhana; Sudhakar, Yajamans

    2014-01-01

    Proniosomes refer to a flexible vesicular carrier with the potential for drug administration through the transdermal route. A proniosome gel type transdermal delivery system of Atenolol was prepared and extensively studied both in vitro drug release and ex vivo permeation studies. The prepared formulations were evaluated for vesicle size, entrapment efficiency, in vitro drug loading, and drug release studies. The release of drug had shown considerable improvement in controlled manner from the prepared gel formulation. It was observed that Span 40 & 60 (A 8) based formulations shows vesicles of minimum size and higher entrapment efficiency compared to the other formulations. Proniosomal transdermal therapeutic system (A 8) was found to be the optimized formulation as it possess good drug release and shows permeation in a steady-state manner over a desired period of time. Also the drug diffusion across snake sheded skin, guinea pig abdomen skin, albino rat, porcine ear correlates better with in vitro drug release studies. The formulation was found to be stable when stored at room temperature and at refrigeration temperature (4 ± 2°C) for 90 days. PMID:24374439

  13. Formulation and evaluation of mouth disintegrating tablets of atenolol and atorvastatin.

    PubMed

    Sarfraz, R M; Khan, H U; Mahmood, A; Ahmad, M; Maheen, S; Sher, M

    2015-01-01

    In this study, mouth-disintegrating tablets of atenolol and atorvastatin combination were formulated using superdisintegrants to impart fast disintegration. Fifteen formulations were prepared based on different concentrations of two superdisintegrants, croscarmellose sodium and Kyron-T134. Three different techniques such as direct compression, effervescent and sublimation were used to study the effect of manufacturing processes, nature and concentration of superdisintegrants on various features of these tablets. Five formulations were made using each method. Precompression studies like bulk density, tapped density, angle of repose, Carr's compressibility index, Hausner's ratio and compatibility studies such as Fourier transform infrared spectroscopy and differential scanning calorimetry were performed. Various features such as hardness, thickness, diameter, weight variation, friability, disintegration time, dissolution studies, wetting time, wetting volume, water absorption ratio, modified disintegration, uniformity of contents and stability were evaluated. Finally results were statistically analyzed by the application of one way ANOVA test. Formulation F13 containing Kyron-T134 (6%) and croscarmellose sodium (2%) was found to be the best among all fifteen formulations prepared in all aspects evaluated. Sublimation method is found to be the best among three methods of preparation used. PMID:25767322

  14. Formulation and Evaluation of Mouth Disintegrating Tablets of Atenolol and Atorvastatin

    PubMed Central

    Sarfraz, R. M.; Khan, H. U.; Mahmood, A.; Ahmad, M.; Maheen, S.; Sher, M.

    2015-01-01

    In this study, mouth-disintegrating tablets of atenolol and atorvastatin combination were formulated using superdisintegrants to impart fast disintegration. Fifteen formulations were prepared based on different concentrations of two superdisintegrants, croscarmellose sodium and Kyron-T134. Three different techniques such as direct compression, effervescent and sublimation were used to study the effect of manufacturing processes, nature and concentration of superdisintegrants on various features of these tablets. Five formulations were made using each method. Precompression studies like bulk density, tapped density, angle of repose, Carr's compressibility index, Hausner's ratio and compatibility studies such as Fourier transform infrared spectroscopy and differential scanning calorimetry were performed. Various features such as hardness, thickness, diameter, weight variation, friability, disintegration time, dissolution studies, wetting time, wetting volume, water absorption ratio, modified disintegration, uniformity of contents and stability were evaluated. Finally results were statistically analyzed by the application of one way ANOVA test. Formulation F13 containing Kyron-T134 (6%) and croscarmellose sodium (2%) was found to be the best among all fifteen formulations prepared in all aspects evaluated. Sublimation method is found to be the best among three methods of preparation used. PMID:25767322

  15. [Enantioseparation and determination of atenolol enantiomers in tables on a ?-cyclodextrin-based chiral stationary phase by high performance liquid chromatography].

    PubMed

    Cheng, Biaoping; Li, Laisheng; Zhou, Rendan; Nie, Guizhen; Zhang, Hongfu

    2014-11-01

    A novel dinitrophenyl ether ?-cyclodextrin-bonded chiral stationary phase (NESP) for HPLC was prepared with ordered mesoporous SBA-15 as matrix. The fast enantioseparation of atenolol enantiomers on the new stationary phase was achieved through the optimization of mobile phase composition, column temperature and other factors in polar organic solvent mode. The optimized composition of mobile phase was acetonitrile/methanol/glacial acetic acid/triethylamine (90:10:2.5:3.0, v/v/v/v) at the flow rate of 0.5 mL/min. The column tem- perature was set at 20 °C. The detection wavelength was 275 nm. The resolution of atenolol enantiomers was 1.73 with a rather short analysis time, about 20 min, under the above conditions. The atenolol was extracted with methanol from the tablets and analyzed by direct injection for HPLC. A new quantitative method of atenolol enantiomers in tablets was established after the condition optimization. The good linear relationships for two atenolol enantiomers were observed in the range of 2.5-100 mg/L with r of 0. 999 2 and 0. 998 9, respectively. The recoveries of atenolol enantiomers in tablet samples were 94.60%-97.24%. The relative standard deviations (RSDs) of this method were not greater than 0.92% for intra-day and 1.86% for inter-day, respectively. The detection limits (S/N = 3) of concentrations were less than 0.2 mg/L for both enantiomers. The established method is simple and of high selectivity, high recovery and low cost for enantiomer analysis by using homemade cyclodextrin-based chiral column. It has a good application prospect for the fast quality control and the pharmacokinetics study of chiral drugs. PMID:25771541

  16. Nitrate-induced photodegradation of atenolol in aqueous solution: kinetics, toxicity and degradation pathways.

    PubMed

    Ji, Yuefei; Zeng, Chao; Ferronato, Corinne; Chovelon, Jean-Marc; Yang, Xi

    2012-07-01

    The extensive utilization of ?-blockers worldwide led to frequent detection in natural water. In this study the photolysis behavior of atenolol (ATL) and toxicity of its photodegradation products were investigated in the presence of nitrate ions. The results showed that ATL photodegradation followed pseudo-first-order kinetics upon simulated solar irradiation. The photodegradation was found to be dependent on nitrate concentration and increasing the nitrate from 0.5 mML(-1) to 10 mML(-1) led to the enhancement of rate constant from 0.00101 min(-1) to 0.00716 min(-1). Hydroxyl radical was determined to play a key role in the photolysis process by using isopropanol as molecular probe. Increasing the solution pH from 4.8 to 10.4, the photodegradation rate slightly decreased from 0.00246 min(-1) to 0.00195 min(-1), probably due to pH-dependent effect of nitrate-induced .OH formation. Bicarbonate decreased the photodegradation of ATL in the presence of nitrate ions mainly through pH effect, while humic substance inhibited the photodegradation via both attenuating light and competing radicals. Upon irradiation for 240 min, only 10% reduction of total organic carbon (TOC) can be achieved in spite of 72% transformation rate of ATL, implying a majority of ATL transformed into intermediate products rather than complete mineralization. The main photoproducts of ATL were identified by using solid phase extraction-liquid chromatography-mass spectrometry (SPE-LC-MS) techniques and possible nitrate-induced photodegradation pathways were proposed. The toxicity of the phototransformation products was evaluated using aquatic species Daphnia magna, and the results revealed that photodegradation was an effective mechanism for ATL toxicity reduction in natural waters. PMID:22497785

  17. A highly sensitive LC-MS/MS method capable of simultaneously quantitating celiprolol and atenolol in human plasma for a cassette cold-microdosing study.

    PubMed

    Minamide, Yoshiyuki; Osawa, Yukio; Nishida, Hiroshi; Igarashi, Harue; Kudoh, Shinobu

    2011-07-01

    A highly sensitive simultaneous quantitative method for a cassette cold-microdosing study on celiprolol and atenolol was developed with liquid chromatography-tandem mass spectrometry. The method utilizes a combination of solid-phase extraction (SPE) with strong cation exchange (SCX) cartridge columns and reversed-phase chromatography with an ODS analytical column. SCX-SPE cartridge columns (100 mg sorbent) were used for a selective extraction of celiprolol, atenolol and metoprolol (internal standard) from 500 ?L of human plasma samples. Turbo-ion spray at positive mode was employed for the ionization of the drug compounds. Quantitation was performed on a triple quadrupole mass spectrometer by selected reaction monitoring with the transitions of m/z 380 to m/z 251 for celiprolol and m/z 267 to m/z 145 for atenolol. Separation of analytes was achieved on an ODS column (100 mm length × 2.1 mm id, 3 ?m) by a gradient elution with 10 mM formic acid and methanol by varying their proportion at a flow rate of 0.2 mL/min. The method was validated in the range of 1-250 pg/mL for celiprolol and 2.5-250 pg/mL for atenolol and was successfully applied to the elucidation of pharmacokinetic profiling in a cold cassette microdosing study of the ?-blockers. PMID:21595025

  18. Comparison of Moringa oleifera Leaves Extract with Atenolol on Serum triglyceride, Serum Cholesterol, Blood glucose, heart weight, body weight in Adrenaline Induced Rats

    Microsoft Academic Search

    Naznin Ara; Mamunur Rashid

    The research work was investigated to compare the effects of Moringa oleifera with atenolol on serum cholesterol level, serum triglyceride level, blood glucose level, heart weight and body weight of adrenaline induced rats (AIR) in a crossover design. The pharmacologically active components responsible for above-mentioned activities were isolated from plant using bioassay guided purification approach and the structures of the

  19. Effects of low-dose atenolol on postural and postprandial changes in heart rate, blood pressure, venous plasma catecholamines, and plasma renin activity

    Microsoft Academic Search

    C. de Mey; S. Hansen-Schmidt; D. Enterling; I. Meineke

    1989-01-01

    The administration of a single dose of atenolol 50 mg 1 h before a standard 3100 kJ cold meal in fasting healthy subjects reduced the supine preprandial heart rate and systolic blood pressure, and blunted the postural and postprandial rises in mean heart rate and systolic blood pressure relative to placebo. It did not affect the preprandial supine diastolic blood

  20. Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behavior, without changing mice longevity

    PubMed Central

    Gómez, Alexia; Sánchez-Roman, Ines; Gomez, Jose; Cruces, Julia; Mate, Ianire; Lopez-Torres, Mónica; Naudi, Alba; Portero-Otin, Manuel; Pamplona, Reinald; De la Fuente, Monica; Barja, Gustavo

    2014-01-01

    The membrane fatty acid unsaturation hypothesis of aging and longevity is experimentally tested for the first time in mammals. Lifelong treatment of mice with the ?1-blocker atenolol increased the amount of the extracellular-signal-regulated kinase signaling protein and successfully decreased one of the two traits appropriately correlating with animal longevity, the membrane fatty acid unsaturation degree of cardiac and skeletal muscle mitochondria, changing their lipid profile toward that present in much more longer-lived mammals. This was mainly due to decreases in 22:6n-3 and increases in 18:1n-9 fatty acids. The atenolol treatment also lowered visceral adiposity (by 24%), decreased mitochondrial protein oxidative, glycoxidative, and lipoxidative damage in both organs, and lowered oxidative damage in heart mitochondrial DNA. Atenolol also improved various immune (chemotaxis and natural killer activities) and behavioral functions (equilibrium, motor coordination, and muscular vigor). It also totally or partially prevented the aging-related detrimental changes observed in mitochondrial membrane unsaturation, protein oxidative modifications, and immune and behavioral functions, without changing longevity. The controls reached 3.93 years of age, a substantially higher maximum longevity than the best previously described for this strain (3.0 years). Side effects of the drug could have masked a likely lowering of the endogenous aging rate induced by the decrease in membrane fatty acid unsaturation. We conclude that it is atenolol that failed to increase longevity, and likely not the decrease in membrane unsaturation induced by the drug. PMID:24612513

  1. Randomized double-blind, placebo-controlled trial of oral atenolol in patients with unexplained syncope and positive upright tilt table test results

    Microsoft Academic Search

    Nithi Mahanonda; Kiertijai Bhuripanyo; Charuwan Kangkagate; Kanchana Wansanit; Bang-on Kulchot; Koonlawee Nademanee; Suphachai Chaithiraphan

    1995-01-01

    The objective of this investigation was the assessment of the response rate of oral atenolol in patients with vasovagal syncope after 1 month of treatment. We randomized into two groups all patients referred to our unit who had had at least one episode of syncope or two episodes of presyncope 1 month before presentation and had a positive isuprel Tilt

  2. The in vitro effects of propranolol and atenolol on neutrophil motility and post-phagocytic metabolic activity.

    PubMed Central

    Anderson, R; van Rensburg, A J

    1979-01-01

    Propranolol at concentrations of 1 x 10(-6) to 1 x 10(-4) M consistently increased neutrophil motility as measured in Boyden chambers. The effects were not due solely to stimulation of random migration and chemokinesis but also of directional motility. Propranolol, over a similar concentration range, caused inhibition of post-phagocytic cell metabolic activity (hexose monophosphate shunt, nitro-blue tetrazolium reduction and protein iodination) without any detectable effect on the ingestion rate of Candida albicans. Atenolol had no effect on any of these neutrophil functions. Both drugs were without effect on glycolysis and intracellular cyclic AMP levels. Propranolol however, at concentrations which stimulated cell motility, caused increased intracellular cyclic GMP levels. It is suggested that propranolol may stimulate neutrophil motility by promoting increased intracellular cyclic GMP levels or by decreasing neutrophil superoxide production. PMID:223974

  3. Excimer formation in inclusion complexes of ?-cyclodextrin with salbutamol, sotalol and atenolol: Spectral and molecular modeling studies

    NASA Astrophysics Data System (ADS)

    Antony Muthu Prabhu, A.; Subramanian, V. K.; Rajendiran, N.

    2012-10-01

    The inclusion complexation behavior of salbutamol, sotalol and atenolol drugs with ?-cyclodextrin (?-CD) were investigated by UV-visible, fluorometry, time resolved fluorescence, FT-IR, 1H NMR, SEM and PM3 methods. The above drugs gave a single emission maximum in water where as dual emission in ?-CD. In ?-CD solutions the shorter wavelength fluorescence intensity was regularly decreased and longer wavelength fluorescence intensity increased. Addition of ?-CD to aqueous solutions of drugs resulted into excimer emission. The excimer emission is concluded to be due to a 1:2 inclusion complex between ?-CD and drug. Nanosecond time-resolved studies indicated that all drugs exhibited biexponential decay in solvents and triexponential decay in CD. Investigations of thermodynamic and electronic properties confirmed the stability of the inclusion complex.

  4. Inhibitory effect of atenolol on urinary excretion of metformin via down-regulating multidrug and toxin extrusion protein 1 (rMate1) expression in the kidney of rats.

    PubMed

    Ma, Yan-rong; Huang, Jing; Shao, Yun-yun; Ma, Kang; Zhang, Guo-qiang; Zhou, Yan; Zhi, Rao; Qin, Hong-yan; Wu, Xin-an

    2015-02-20

    Renal tubular secretion is an important pathway for the elimination of many clinically used drugs. Metformin, a commonly prescribed first-line antidiabetic drug, is secreted primarily by the renal tubule. Many patients with type 2 diabetes mellitus (T2DM) receiving metformin may together be given selective ?1 blockers (e.g., atenolol). Therefore, it is of great use to evaluate the effect of atenolol on metformin urinary excretion for exploring drug interactions and predicting the adverse effect of drugs. The aim of this study was to investigate the effect of atenolol on the pharmacokinetic of metformin and plasma lactate (LCA) level in rats, for high LCA is a serious adverse reaction of metformin after long-term metformin treatment. In this study, rats were treated with metformin alone or in combination with atenolol. Plasma, urine and tissue concentration of metformin was determined by HPLC method, while Western blotting and immunohistochemical analysis were used to evaluate the renal expression of rat organic cation transporter 2 (rOct2) and multidrug and toxin extrusion protein 1 (rMate1). The results showed that, after 7 days drug treatment, the AUC0 ? t of metformin in atenolol and metformin co-administration group was significantly increased by 19.5% compared to that in metformin group, while the 24h cumulative urinary excretion of metformin was significantly decreased by 57.3%. In addition, atenolol treatment significantly decreased the renal expression of rMate1, but had no effect on rOct2 expression, renal blood perfusion and glomerular filtration. Moreover, plasma LCA level in atenolol and metformin co-administration group was significantly increased by 83.3% compared to that in metformin group after 60 days drug treatment. These results indicated that atenolol can inhibit urinary excretion of metformin via decreasing renal rMate1 expression, and long-term atenolol and metformin co-administration may induce potential lactic acidosis. Our results, for the first time, provided an important experimental evidence that rMate1 is the target of transporter-mediated drug interactions concerning metformin and atenolol. PMID:25486332

  5. Optimal control of myocardial ischaemia: the benefit of a fixed combination of atenolol and nifedipine in patients with chronic stable angina

    Microsoft Academic Search

    Hassan El-Tamimi; Graham J Davies

    1992-01-01

    Objective—To study the effects on myocardial ischaemia of 50 mg of atenolol, 20 mg of slow release nifedipine, and their fixed combination given 12 hourly.Design—A treadmill exercise test and 24 hour ambulatory electrocardiographic monitoring were carried out after a period of five days off treatment (control) and at the end of three weeks of each treatment period.Patients—23 patients with stable

  6. Effect of aged garlic extract and s-allyl cysteine and their interaction with atenolol during isoproterenol induced myocardial toxicity in rats

    PubMed Central

    Avula, Pulla Reddy; Asdaq, Syed Mohammed; Asad, Mohammed

    2014-01-01

    Objectives: The study evaluates the cardioprotective effect of aged garlic extract (AGE) and its constituent; S-allylcysteine (SAC) and their interaction with atenolol during isoproterenol induced cardiac toxicity in rats. Materials and Methods: Rats were administered AGE at two different doses of 2 ml/kg or 5 ml/kg orally whereas SAC was administered either at a dose 13.1 mg/kg or 32.76 mg/kg. The AGE or SAC was given alone or in combination with atenolol (6 mg/kg, p.o), every alternate day for three weeks. At the end of treatment, two doses of isoproterenol (150 mg/kg, s.c) were administered to rats. The electrocardiogram (ECG) was recorded followed by withdrawal of blood to estimate serum lactate dehydrogenase (LDH) and creatinine kinase-MB (CK-MB) activities. The activities of LDH, CK-MB as well as superoxide dismutase (SOD), catalase and thiobarbituric acid reactive substances (TBARS) were also determined in the heart tissue homogenate (HTH). Results: The isoproterenol induced ECG changes were restored to normal in all treated groups. The AGE and SAC administration caused a decrease in serum LDH and CK-MB activities and an elevation of LDH and CK-MB activities in HTH. Atenolol alone or in combination with AGE and S-allylcsyteine demonstrated similar changes in biomarker activities. Conclusion: AGE showed dose-dependent cardioprotection. However, concurrent administration of SAC with atenolol (6 mg/kg, p.o) combated more effectively the myocardial dysfunction during isoproterenol induced cardiotoxicity in rats. PMID:24550592

  7. Randomised, double blind, multicentre comparison of hydrochlorothiazide, atenolol, nitrendipine, and enalapril in antihypertensive treatment: results of the HANE study. HANE Trial Research Group.

    PubMed Central

    Philipp, T.; Anlauf, M.; Distler, A.; Holzgreve, H.; Michaelis, J.; Wellek, S.

    1997-01-01

    OBJECTIVE: To compare the effectiveness and tolerability of hydrochlorothiazide, atenolol, nitrendipine, and enalapril in patients with mild to moderate hypertension. DESIGN: Randomised multicentre trial over 48 weeks with double blind comparison of treatments. SETTING: 48 centres in four countries. PATIENTS: 868 patients with essential hypertension (diastolic blood pressure 95-120 mm Hg) INTERVENTIONS: Initial treatment (step 1) consisted of 12.5 mg hydrochlorothiazide (n = 215), 25 mg atenolol (n = 215), 10 mg nitrendipine (n = 218), or 5 mg enalapril (n = 220) once daily. If diastolic blood pressure was not reduced to < 90 mm Hg within four weeks, doses were increased to 25 mg, 50 mg, 20 mg, 10 mg, respectively, once daily (step 2) and after two more weeks to twice daily (step 3). The eight week titration phase was followed by an additional 40 weeks for patients who had reached the target diastolic pressure. MAIN OUTCOME MEASURES: Blood pressure by means of an automatic device with repeated measurements. RESULTS: After eight weeks the response rate for atenolol (63.7%) was significantly higher than for enalapril (50.0%), hydrochlorothiazide (44.7%), or nitrendipine (44.5%). After one year atenolol was still more effective (48.0%) than hydrochlorothiazide (35.4%) and nitrendipine (32.9%), but not significantly better than enalapril (42.7%). The treatment related dropout rate was higher (P < 0.001) in the nitrendipine group (n = 28). CONCLUSIONS: There is no evidence of superiority for antihypertensive effectiveness or tolerability of the "new" classes of antihypertensives (calcium channel blockers and angiotensin converting enzyme inhibitors). As these drugs are now widely used as treatment of first choice, our results further emphasise the need for studies confirming that they also reduce morbidity and mortality, as has been shown for diuretics and beta blockers. PMID:9251545

  8. RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ATORVASTATIN CALCIUM, LOSARTAN POTASSIUM, ATENOLOL, AND ASPIRIN FROM TABLET DOSAGE FORM AND PLASMA

    Microsoft Academic Search

    Neela M. Bhatia; Sachin B. Gurav; Swapnil D. Jadhav; Manish S. Bhatia

    2012-01-01

    A rapid, simple, sensitive, and selective chromatographic method has been developed for the simultaneous estimation of atorvastatin calcium, losartan potassium, atenolol, and aspirin in marketed formulation. The separation was carried out on a KYA TECH HiQ Sil C18HS (250 × 4.6 mm i.d., 5 µm particle size) column using a mobile phase of acetonitrile: 0.02 M potassium dihydrogen phosphate buffer (pH 3.4) (70:30% v\\/v). The

  9. Sensitive Spectrophotometric Determination of Atenolol in Pharmaceutical Formulations Using Bromate-Bromide Mixture as an Eco-Friendly Brominating Agent

    PubMed Central

    Prashanth, Kudige N.; Basavaiah, Kanakapura

    2012-01-01

    Three simple and sensitive spectrophotometric methods are proposed for the determination of atenolol (ATN) in bulk drug and tablets. The methods are based on the bromination of ATN by the bromine generated in situ by the action of the acid on the bromate–bromide mixture followed by the determination of unreacted bromine by reacting with a fixed amount of either meta-cresol purple (MCP) and measuring the absorbance at 540?nm (method A) and 445?nm (method B) or erioglaucine (EGC) and measuring the absorbance at 630?nm (method C). Beer's law is valid within the concentration ranges of 1.0–20.0, 2.0–40.0 and 1.0–8.0??g/mL for method A, method B and method C, respectively. The calculated molar absorptivities were found to be 1.20×104, 4.51×103 and 3.46 × 104??L/mol · cm for method A, method B and method C, respectively. Sandell's sensitivity values, correlation coefficients, limits of detection and quantification are also reported. Recovery results were statistically compared with those of a reference method by applying Student's t- and F-test. The novelty of the present study is the measurement of two different colors using MCP, that is, red-pink color of MCP in acid medium at 540?nm and yellowish-orange color of brominated MCP at 445?nm. PMID:22567567

  10. Long-Term Treatment of Clonidine, Atenolol, Amlodipine and Dihydrochlorothiazide, but Not Enalapril, Impairs the Sexual Function in Male Spontaneously Hypertensive Rats

    PubMed Central

    Lin, Li-Li; Wang, Dong; Wang, Wei; Cheng, Yan-Qiong; Su, Ding-Feng; Liu, Ai-Jun

    2015-01-01

    This study was designed to investigate the impact of representative antihypertensive drugs of 5 classes on the sexual function in male spontaneously hypertensive rats (SHR) at doses that achieved similar blood pressure (BP) reduction. The experiment was performed in 6 groups of male SHR. The dose are 20 ?g/kg/day for clonidine, 3 mg/kg/day for enalapril, 20 mg/kg/day for atenolol, 2 mg/kg/day for amlodipine, and 10 mg/kg/day for dihydrochlorothiazide. SHR were treated for 3 months, and then the penile erection and sexual behavior were detected. After BP recording, SHR were killed to evaluate the organ-damage, weight of accessory sex organs and levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone in serum. Five drugs had the similar efficacy on BP reduction. All drugs except of enalapril, significantly prolonged the mount latency, and decreased the mount frequency (P<0.05). Clonidine also reduced the conception rate (45% vs. 80% in control group, P<0.05). Amlodipine and dihydrochlorothiazide significantly increased the testosterone level (0.79±0.30, 0.80±0.34 vs. 0.49±0.20 in control group, unit: ng/dl, P<0.05). Enalapril, atenolol and amlodipine also significantly decreased the BP variability (systolic, 8.2±2.5, 7.6±1.8, 8.9±2.0 vs. 12.2±3.8 in control group, unit: mm Hg). All these drugs significantly decreased the organ-damage (P<0.05). In conclusion, long-term treatment with 5 common antihypertensive drugs possessed obvious organ protection in SHR. Clonidine, atenolol, amlodipine and dihydrochlorothiazide, but not enalapril, impair sexual function. PMID:25615941

  11. Long-term treatment of clonidine, atenolol, amlodipine and dihydrochlorothiazide, but not enalapril, impairs the sexual function in male spontaneously hypertensive rats.

    PubMed

    Lin, Li-Li; Wang, Dong; Wang, Wei; Cheng, Yan-Qiong; Su, Ding-Feng; Liu, Ai-Jun

    2015-01-01

    This study was designed to investigate the impact of representative antihypertensive drugs of 5 classes on the sexual function in male spontaneously hypertensive rats (SHR) at doses that achieved similar blood pressure (BP) reduction. The experiment was performed in 6 groups of male SHR. The dose are 20 ?g/kg/day for clonidine, 3 mg/kg/day for enalapril, 20 mg/kg/day for atenolol, 2 mg/kg/day for amlodipine, and 10 mg/kg/day for dihydrochlorothiazide. SHR were treated for 3 months, and then the penile erection and sexual behavior were detected. After BP recording, SHR were killed to evaluate the organ-damage, weight of accessory sex organs and levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone in serum. Five drugs had the similar efficacy on BP reduction. All drugs except of enalapril, significantly prolonged the mount latency, and decreased the mount frequency (P<0.05). Clonidine also reduced the conception rate (45% vs. 80% in control group, P<0.05). Amlodipine and dihydrochlorothiazide significantly increased the testosterone level (0.79±0.30, 0.80±0.34 vs. 0.49±0.20 in control group, unit: ng/dl, P<0.05). Enalapril, atenolol and amlodipine also significantly decreased the BP variability (systolic, 8.2±2.5, 7.6±1.8, 8.9±2.0 vs. 12.2±3.8 in control group, unit: mm Hg). All these drugs significantly decreased the organ-damage (P<0.05). In conclusion, long-term treatment with 5 common antihypertensive drugs possessed obvious organ protection in SHR. Clonidine, atenolol, amlodipine and dihydrochlorothiazide, but not enalapril, impair sexual function. PMID:25615941

  12. DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC (HPLC) METHOD FOR ATENOLOL AND HYDROCHLORTHIAZIDE IN BULK DRUG AND TABLET FORMULATION

    Microsoft Academic Search

    S. P. GANDHI; S. J. RAJPUT

    A new simple, rapid, precise, accurate, specific and stability indicating assay method was developed for simultaneous estimation of Atenolol (ATN) and Hydrochlorthiazide (HCZ) in pure form and tablet form. The analytes were separated by RP HPLC on a Hypersil-BDS C18 column (250X4.6mm i.d., 5mm).The mobile phase was 25mMphosphate buffer (PH 3±0.05): acetonitrile (85:15, v\\/v) at 0.7 mL\\/min satisfactorily resolved the

  13. Effects of Verapamil SR and Atenolol on 24-Hour Blood Pressure and Heart Rate in Hypertension Patients with Coronary Artery Disease: An International Verapamil SR-Trandolapril Ambulatory Monitoring Substudy

    PubMed Central

    Denardo, Scott J.; Gong, Yan; Cooper-DeHoff, Rhonda M.; Farsang, Csaba; Keltai, Matyas; Szirmai, László; Messerli, Franz H.; Bavry, Anthony A.; Handberg, Eileen M.; Mancia, Giuseppe; Pepine, Carl J.

    2015-01-01

    Elevated nighttime blood pressure (BP) and heart rate (HR), increased BP and HR variability, and altered diurnal variations of BP and HR (nighttime dipping and morning surge) in patients with systemic hypertension are each associated with increased adverse cardiovascular events. However, there are no reports on the effect of hypertension treatment on these important hemodynamic parameters in the growing population of hypertensive patients with atherosclerotic coronary artery disease (CAD). This was a pre-specified subgroup analysis of the INternational VErapamil SR-Trandolapril STudy (INVEST), which involved 22,576 clinically stable patients aged ?50 years with hypertension and CAD randomized to either verapamil SR- or atenolol-based hypertension treatment strategies. The subgroup consisted of 117 patients undergoing 24-hour ambulatory monitoring at baseline and after 1 year of treatment. Hourly systolic and diastolic BP (SBP and DBP) decreased after 1 year for both verapamil SR- and atenolol-based treatment strategies compared with baseline (P<0.0001). Atenolol also decreased hourly HR (P<0.0001). Both treatment strategies decreased SBP variability (weighted standard deviation: P = 0.012 and 0.021, respectively). Compared with verapamil SR, atenolol also increased the prevalence of BP and HR nighttime dipping among prior non-dippers (BP: OR = 3.37; 95% CI: 1.26 – 8.97; P = 0.015; HR: OR = 4.06; 95% CI: 1.35-12.17; P = 0.012) and blunted HR morning surge (+2.8 vs. +4.5 beats/min/hr; P = 0.019). Both verapamil SR- and especially atenolol-based strategies resulted in favorable changes in ambulatory monitoring parameters that have been previously associated with increased adverse cardiovascular events. Trial Registration Clinicaltrials.gov; NCT00133692 PMID:25835002

  14. Development of a MSFIA sample treatment system as front end of GC-MS for atenolol and propranolol determination in human plasma.

    PubMed

    Brunetto, María del Rosario; Clavijo, Sabrina; Delgado, Yelitza; Orozco, Wendy; Gallignani, Máximo; Ayala, Carlos; Cerdà, Víctor

    2015-01-01

    An on-line solid-phase extraction (SPE) method coupled to gas chromatography-mass spectrometry (GC-MS) has been developed for the determination of atenolol (ATN) and propranolol (PRO) in human plasma. The hyphenation of SPE with multisyringe flow injection analysis (MSFIA) allows the simultaneous GC-MS determination of ATN and PRO with high selectivity and sensitivity. On-line preconcentration and derivatisation of the analytes were carried out by means of using restricted access materials (RAM) and microwave (MW) assisted derivatisation reactions with N-methyl-N-(trimethylsilyl) trifluoroacetamide (MSTFA)+1% trimethylchlorosilane (TMCS). Multivariate optimization was applied to optimize experimental conditions. The whole procedure comprising sample pretreatment and analyte determination took about 15 min. However, the overlap of the automatic sample treatment with the GC separation increased the frequency to 7 samples h(-1). The validated method was successfully applied to direct ATN and PRO determination in human plasma. PMID:25476273

  15. Chords: Em 022000 Em Em Em Em C C C C

    E-print Network

    Reiners, Peter W.

    Verse 1 Chorus Verse 2 Chorus Verse 3 Chords: Em 022000 C 035553 G 320002 F 133211 Intro: Em Em Em Em C C C C Em Em Em Em C C C C Em Em Em Em C C C C Em Em Em Em C C C C Verse: Em Em Em Em C C C C G G G G G G G G Em Em Em Em C C C C G G G G G G G G Em Em Em Em C C C C G G G G G G G G Em Em Em Em C C

  16. Development and validation of RP-HPLC-UV method for simultaneous determination of buparvaquone, atenolol, propranolol, quinidine and verapamil: a tool for the standardization of rat in situ intestinal permeability studies.

    PubMed

    Venkatesh, Gantala; Ramanathan, S; Mansor, S M; Nair, N K; Sattar, Munavvar Abdul; Croft, Simon L; Navaratnam, V

    2007-03-12

    A simple, sensitive and specific reversed phase high performance liquid chromatographic (RP-HPLC) method with UV detection at 251 nm was developed for simultaneous quantitation of buparvaquone (BPQ), atenolol, propranolol, quinidine and verapamil. The method was applicable in rat in situ intestinal permeability study to assess intestinal permeability of BPQ, a promising lead compound for Leishmania donovani infections. The method was validated on a C-4 column with mobile phase comprising ammonium acetate buffer (0.02 M, pH 3.5) and acetonitrile in the ratio of 30:70 (v/v) at a flow rate of 1.0 ml/min. The retention times for atenolol, quinidine, propranolol, verapamil and BPQ were 4.30, 5.96, 6.55, 7.98 and 8.54 min, respectively. The calibration curves were linear (correlation coefficient > or =0.996) in the selected range of each analyte. The method is specific and sensitive with limit of quantitation of 15 microg/ml for atenolol, 0.8 microg/ml for quinidine, 5 microg/ml for propranolol, 10 microg/ml for verapamil and 200 ng/ml for BPQ. The validated method was found to be accurate and precise in the working calibration range. Stability studies were carried out at different storage conditions and all the analytes were found to be stable. This method is simple, reliable and can be routinely used for accurate permeability characterization. PMID:17157469

  17. Characteristics of children and young adults with Marfan syndrome and aortic root dilation in a randomized trial comparing atenolol and losartan therapy

    PubMed Central

    Lacro, Ronald V.; Guey, Lin T.; Dietz, Harry C.; Pearson, Gail D.; Yetman, Anji T.; Gelb, Bruce D.; Loeys, Bart L.; Benson, D. Woodrow; Bradley, Timothy J.; De Backer, Julie; Forbus, Geoffrey A.; Klein, Gloria L.; Lai, Wyman W.; Levine, Jami C.; Lewin, Mark B.; Markham, Larry W.; Paridon, Stephen M.; Pierpont, Mary Ella; Radojewski, Elizabeth; Selamet Tierney, Elif Seda; Sharkey, Angela M.; Wechsler, Stephanie Burns; Mahony, Lynn

    2013-01-01

    Background The Pediatric Heart Network designed a clinical trial to compare aortic root growth and other short-term cardiovascular outcomes in children and young adults with Marfan syndrome randomized to receive atenolol or losartan. We report here the characteristics of the screened population and enrolled subjects. Methods and results Between 2007 and 2011, 21 clinical sites randomized 608 subjects, aged 6 months to 25 years who met the original Ghent criteria and had a body surface area–adjusted aortic root diameter z-score >3.0. The mean age at study entry was 11.2 years, 60% were male, and 25% were older teenagers and young adults. The median aortic root diameter z-score was 4.0. Aortic root diameter z-score did not vary with age. Mitral valve prolapse and mitral regurgitation were more common in females. Among those with a positive family history, 56% had a family member with aortic surgery, and 32% had a family member with a history of aortic dissection. Conclusions Baseline demographic, clinical, and anthropometric characteristics of the randomized cohort are representative of patients in this population with moderate to severe aortic root dilation. The high percentage of young subjects with relatives who have had aortic dissection or surgery illustrates the need for more definitive therapy; we expect that the results of the study and the wealth of systematic data collected will make an important contribution to the management of individuals with Marfan syndrome. PMID:23622922

  18. Multivariate curve resolution-alternating least squares assisted by voltammetry for simultaneous determination of betaxolol and atenolol using carbon nanotube paste electrode.

    PubMed

    Khoobi, Asma; Ghoreishi, Sayed Mehdi; Masoum, Saeed; Behpour, Mohsen

    2013-12-01

    In the present work differential pulse voltammetry coupled with multivariate curve resolution-alternating least squares (MCR-ALS) was applied for simultaneous determination of betaxolol (Bet) and atenolol (Ate) in 0.20 M Britton-Robinson (B-R) buffer solution at the surface of a multi-walled carbon nanotube modified carbon paste electrode (MWCNT/CPE). Characterization of the modified electrode was carried out by electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). A strategy based on experimental design was followed. Operating conditions were improved with central composite rotatable design (CCRD) and response surface methodology (RSM), involving several chemical and instrumental parameters. Then second order data were built from variable pulse heights of DPV and after correction in potential shift analyzed by MCR-ALS. Analytical parameters such as linearity, repeatability, and stability were also investigated and a detection limit (DL) of 0.19 and 0.29 ?M for Bet and Ate was achieved, respectively. The proposed method was successfully applied in simultaneous determining the two analytes in human plasma. PMID:23632433

  19. Direct injection of large volumes of plasma/serum on a new biocompatible extraction column for the determination of atenolol, propranolol and ibuprofen. Mechanisms for the improvement of chromatographic performance.

    PubMed

    Hermansson, J; Grahn, A; Hermansson, I

    1998-02-27

    Very large volumes of serum/plasma can be directly injected to a new extraction column based on particles with a biocompatible outer surface and C18 groups within the pores. The biocompatibility has been obtained by attaching the human plasma protein alpha 1-acid glycoprotein to the outer surface of the particles. The pores are small enough to exclude the plasma protein molecules. Atenolol and propranolol were extracted on the extraction column as ion-pair with octanesulfonic acid as the counterion. The same counterion was used in the analytical mobile phase. A strong improvement of the recovery can be obtained using octanesulfonic acid as counterion in the extraction mobile phase. The recovery of atenolol increased from about 53.5% to about 93.4% using octanesulfonic acid as counterion. The chromatographic performance was also strongly affected by chromatography of the basic drugs as ion-pair with octanesulfonic acid. The improvement was due to trapping in a smaller section of the extraction column and enrichment of the drug on top of the analytical column. The enrichment was due to the transfer of the analyte to the analytical column in a zone with high concentration of counterion. Furthermore, the sample zone is compressed during the migration on the analytical column. The compression effect was caused by the counterion zone, migrating in front of the sample zone, giving the analyte higher retention on the front side than on the back side of the sample zone. Displacement of protein bound drug (ibuprofen) by addition of octanoic acid, was tested in order to study the influence on the recovery and the effect on the chromatographic performance. The recovery was improved and the chromatographic performance was greatly improved. The improvement obtained on the separation efficiency of ibuprofen was due to enrichment on top of the analytical column and compression during the migration through the analytical column. The enrichment was caused by a reduction of pH in the sample--octanoic acid zone transferred from the extraction column. The octanoic acid zone migrated in front of the sample zone giving a lower pH in front of the ibuprofen zone than behind. Thus, higher retention occurred in front of than behind the sample zone, which gave rise to compression. The methods developed for atenolol, propranolol and ibuprofen could be used for the determination of serum/plasma concentrations after single doses of the drugs with very high accuracy and precision. Linear calibration graphs were obtained and the r values were > or = 0.9999. PMID:9542118

  20. Valoración del paciente que solicita muerte asistida

    Microsoft Academic Search

    R. Alcázar-Olán; D. Reyes-Chiquete; R. Plancarte-Sánchez

    2003-01-01

    Resumen  El equipo médico debe estar preparado para evaluar a los pacientes que solicitan muerte asistida.\\u000a \\u000a En esta revisión hemos recopilado de la literatura internacional los criterios médicos y psicológicos para evaluar a los pacientes\\u000a que solicitan muerte asistida con la finalidad de aliviar las necesidades fisicas, psicológicas y sociales de los pacientes\\u000a y sus familias.\\u000a \\u000a \\u000a \\u000a Se realizó un estudio de

  1. RELACIÓN MÉDICO PACIENTE: DERECHOS DEL ADULTO MAYOR

    PubMed Central

    Barrantes-Monge, Melba; Rodríguez, Eduardo; Lama, Alexis

    2009-01-01

    Existen prejuicios en relación con la vejez, incluso entre los profesionales que se dedican a la gerontología. Uno común y peligroso es considerar que los viejos son todos enfermos o discapacitados. La relación médico-paciente es la piedra angular de la práctica y ética médicas. Para alcanzar el respeto por los adultos mayores es necesaria una medicina prudente, basada en una práctica en la cual la reflexión ética y clínica pueda contribuir. Esto último es posible si se hacen valer los derechos del adulto mayor, en particular como paciente para la toma de decisiones. PMID:20379380

  2. Seguridad del paciente en los estudios clínicos

    Cancer.gov

    Información para pacientes, sus familiares y amigos, y el público en general, sobre cómo se protegen los derechos y la seguridad de las personas que participan en estudios clínicos. Conozca sobre el consentimiento formal, los consejos institucionales de revisión (IRB) y cómo se realiza la vigilancia continua de los estudios.

  3. Efeitos do alongamento muscular e condicionamento físico no tratamento fi sioterápico de pacientes com fi bromialgia Effects of muscle stretching and physical conditioning as physical therapy treatment for patients with fi bromyalgia

    Microsoft Academic Search

    Bressan LR; Matsutani LA; Assumpção A; Marques AP; Cabral CMN

    Resumo Objetivo: Verifi car os efeitos de exercícios de alongamento muscular e condicionamento físico no tratamento fi sioterápico da fi bromialgia (FM). Casuística e métodos: Foram avaliadas 15 mulheres com diagnóstico de FM, segundo os critérios do Colégio Americano de Reumatologia, divididas em dois grupos: Grupo 1 (G1) com oito pacientes, realizou tratamento por meio de alongamentos musculares e Grupo

  4. Familiares a cargo de pacientes de cáncer (PDQ®)

    Cancer.gov

    Sumario informativo revisado por expertos acerca de los desafíos que enfrentan los familiares a cargo de los pacientes con cáncer. Este resumen se centra en las funciones típicas y las inquietudes de las personas a cargo del paciente y en las intervenciones útiles para esas personas.

  5. Avaliação da circulação arterial pela medida do índice tornozelo\\/braço em doentes de úlcera venosa crônica* Evaluation of arterial circulation using the ankle\\/brachial blood pressure index in patients with chronic venous ulcers

    Microsoft Academic Search

    Fabiane Noronha Bergonse; Evandro Ararigboia Rivitti

    Resumo: FUNDAMENTOS - As úlceras venosas dos membros inferiores são freqüentes e têm grande impacto na qualidade de vida e produtividade do indivíduo, além de alto custo para a saúde pública. OBJETIVOS - Detecção de alterações arteriais em pacientes de úlcera venosa crônica dos mem- bros inferiores com emprego de método não invasivo, de modo a discriminar aqueles em que

  6. Assessment of sexual satisfaction in fibromyalgia patients Avaliação da satisfação sexual em pacientes portadoras de fibromialgia

    E-print Network

    Evelin Diana; Goldenberg Meirelles; Mariano Costa; Maximiliano Cassilha Kneubil; Erson Correa Leão; Karol Bezerra Thé

    2004-01-01

    Objective: To evaluate sexual experience and satisfaction in women with fibromyalgia. Methods: Twenty women with fibromyalgia were compared to 20 normal women using Beck depression inventory and another questionnaire on sexual experience and satisfaction. The following aspects were addressed: age

  7. Eventos arrítmicos en el paciente portador de un desfibrilador automático implantable

    Microsoft Academic Search

    Moreno Ambroj; Salazar González; José Javier; Galache Osuna; José Gabriel; Sánchez-Rubio Lezcano; Blanco González; Sánchez Insa; Guillén Marzo; Araguás Biescas

    2007-01-01

    INTRODUCCIÓN. El Desfibrilador Automático Implantable (DAI) está ideado para prevenir la muerte súbita en pacientes de riesgo: es una estrategia terapéutica de utilidad plenamente establecida como prevención secundaria en pacientes que han padecido arritmias ventriculares malignas y con un número creciente de indicaciones para prevención primaria en pacientes en riesgo de desarrollarlas.

  8. EM International. Volume 1

    SciTech Connect

    Not Available

    1993-07-01

    It is the intent of EM International to describe the Office of Environmental Restoration and Waste Management`s (EM`s) various roles and responsibilities within the international community. Cooperative agreements and programs, descriptions of projects and technologies, and synopses of visits to international sites are all highlighted in this semiannual journal. Focus on EM programs in this issue is on international collaboration in vitrification projects. Technology highlights covers: in situ sealing for contaminated sites; and remote sensors for toxic pollutants. Section on profiles of countries includes: Arctic contamination by the former Soviet Union, and EM activities with Germany--cooperative arrangements.

  9. Equipment management system (EMS)

    Microsoft Academic Search

    T. Yurtsever; M. Comerford

    1995-01-01

    Equipment Management System (EMS) is a software tool used to monitor and track equipment states, restrictions and PM schedules in real time. EMS has been designed and customized to support the MOS-2 die production facility. The system provides graphical representation of the entire factory. Color coded icons represent equipment's current state (i.e. qualification, production, unscheduled maintenance, etc.). Preventative maintenance schedules

  10. Is EM dead?

    PubMed

    Knott, Graham; Genoud, Christel

    2013-10-15

    Since electron microscopy (EM) first appeared in the 1930s, it has held centre stage as the primary tool for the exploration of biological structure. Yet, with the recent developments of light microscopy techniques that overcome the limitations imposed by the diffraction boundary, the question arises as to whether the importance of EM in on the wane. This Commentary describes some of the pioneering studies that have shaped our understanding of cell structure. These include the development of cryo-EM techniques that have given researchers the ability to capture images of native structures and at the molecular level. It also describes how a number of recent developments significantly increase the ability of EM to visualise biological systems across a range of length scales, and in 3D, ensuring that EM will remain at the forefront of biology research for the foreseeable future. PMID:24124192

  11. Environmental Media Services (EMS)

    NSDL National Science Digital Library

    Environmental Media Services (EMS) is a nonprofit communications clearinghouse committed to the expansion of media coverage on critical environmental and public health issues. True to their mission, EMS staff "build relationships with top scientists, physicians, and other experts to bring journalists the latest and most credible information." EMS's modest homepage is free of clutter but full of content. While several sections are under construction and updates (currently) appear irregular, a series of available articles provides useful summaries of important environmental news issues over the past six months. Current articles include "The impacts of global warming on the oceans" and "Cool companies," among others.

  12. OPTIMIZAC ~ AO EM REDES

    E-print Network

    Pascoal, Marta Margarida Braz

    OPTIMIZAC¸ ~ AO EM REDES UMA VIS ~ AO GLOBAL Deolinda Dias Rasteiro, Jose Luis Santos, Marta Braz; Optimiza¸c~ao em Redes ­ Uma Vis~ao Global N = fv 1 ; : : : ; v n g j f1; : : : ; ng ­ conjunto de n'os (v; j) Rede (N ; A) ­ grafo (N ; A) com um v'ertice inicial s e um v'ertice terminal t, a cujos arcos

  13. VALOR DAS PROVAS DE POSICIONAMENTO DA PONTA DA AGULHA DE VERESS EM PUNÇÃO DO HIPOCÔNDRIO ESQUERDO NA INSTALAÇÃO DO PNEUMOPERITÔNIO THE VALUE OF TESTS RESULTS FOR VERESS NEEDLE TIP PLACEMENT INTRAPERITONEALLY IN THE LEFT HYPOCHONDRIUM FOR CREATING A PNEUMOPERITONEUM

    Microsoft Academic Search

    Otávio Cansanção de Azevedo; João Luiz Moreira; Coutinho Azevedo; Albino Augusto Sorbello; Gustavo Peixoto; Soares Miguel; Rodrigo Santa Cruz Guindalini; Antônio Cláudio de Godoy

    RESUMO: Objetivo: Avaliar provas de posicionamento da agulha de Veress no hipocôndrio esquerdo na criação do pneumoperitônio. Método: Em cem pacientes puncionados no hipocôndrio esquerdo, provas de posicionamento da agulha foram avaliadas, conside- rando-as positivas quando, na prova da aspiração ( PA), material orgânico era aspirado; na prova da resistência ( PRes), exercia-se pequena força no êmbolo da seringa à

  14. Familiares a cargo de pacientes de cáncer: funciones y desafíos (PDQ®)

    Cancer.gov

    Sumario informativo revisado por expertos acerca de los desafíos que enfrentan los familiares a cargo de los pacientes con cáncer. Este resumen se centra en las funciones típicas y las inquietudes de las personas a cargo del paciente y en las intervenciones útiles para esas personas.

  15. Impacto de las redes sociales de pacientes en la práctica asistencial

    Microsoft Academic Search

    Elena Torrente; Joan Escarrabill; Tino Martí

    2010-01-01

    Las redes sociales de pacientes son espacios virtuales donde pacientes con condiciones similares se ponen en contacto y comparten tratamientos y problemas de salud. Estas redes ofrecen a las personas con problemas específicos de salud la oportunidad de compartir experiencias, buscar, recibir y proveer información, consejos e incluso apoyo emocional online. Pero, ¿cuál es el impacto de estas redes en

  16. Tratamiento Quirúrgico de los Meningiomas del Foramen Óptico, Técnicay Resultados de una Serie de 18 Pacientes

    PubMed Central

    Goldschmidt, Ezequiel; Ajler, Pablo; Campero, Álvaro; Landriel, Federico; Sposito, Maximiliano; Carrizo, Antonio

    2014-01-01

    Introducción: los meningiomas del foramen óptico producen un rápido deterioro de la función visual aún cuando su tamaño es pequeño, por eso su diagnóstico y manejo difiere del resto de los meningiomas clinoideos. El propósito de este estudio es presentar la técnica y los resultados de nuestro manejo quirúrgico de meningiomas foraminales (MF). Pacientes y Métodos: se llevó a cabo una revisión de las historias clínicas de 47 pacientes con meningiomas primarios intraorbitarios. Se realizaron 52 cirugías en los pacientes con MF. Se empleó una craneotomía fronto-orbitaria, seguida de una descompresión extradural del canal óptico, resección del componente intraorbitario y exploración intradural del nervio óptico. Resultados: de los 12 pacientes con MF que presentaban la visión conservada, la agudeza visual fue preservada en 7 casos, mejoró en 2, y empeoró en 3. En 18 pacientes, el principal síntoma fue exoftalmos y en 35 pacientes ceguera unilateral. Ocurrieron 6 recurrencias, 2 a 10 años después de la resección quirúrgica. Cinco de ellos fueron reoperados. Se indicó radioterapia después de la recurrencia en 3 pacientes. Conclusión: el manejo de los MF continúa siendo controvertido y frecuentemente se propone un tratamiento conservador. Basados en nuestros hallazgos de frecuente extensión intracraneal, proponemos realizar una resección total o subtotal del tumor, preservando el nervio óptico en pacientes con visión prequirúrgica conservada. PMID:25165616

  17. National EMS Research Agenda.

    PubMed

    Sayre, M R; White, L J; Brown, L H; McHenry, S D

    2002-01-01

    Now, more than ever before, the spirit of the emergency services professional is recognized by people everywhere. Individuals from every walk of life comprehend the reality of the job these professionals do each day. Placing the safety of others above their own is their acknowledged responsibility. Rescue and treatment of ill and injured patients are their purpose as well as their gratification. The men and women who provide prehospital care are well aware of the unpredictable nature of emergency medical services (EMS). Prehospital care is given when and where it is needed: in urban settings with vertical challenges and gridlock; in rural settings with limited access; in confined spaces; within entrapments; or simply in the street, exposed to the elements. Despite the challenges, EMS professionals rise to the occasion to do their best with the resources available. Despite more than 30 years of dedicated service by thousands of EMS professionals, academic researchers, and public policy makers, the nation's EMS system is treating victims of illness and injury with little or no evidence that the care they provide is optimal. A national investment in the EMS research infrastructure is necessary to overcome obstacles currently impeding the accumulation of essential evidence of the effectiveness of EMS practice. Funding is required to train new researchers and to help them establish their careers. Financial backing is needed to support the development of effective prehospital treatments for the diseases that drive the design of the EMS system, including injury and sudden cardiac arrest. Innovative strategies to make EMS research easier to accomplish in emergency situations must be implemented. Researchers must have access to patient outcome information in order to evaluate and improve prehospital care. New biomedical and technical advances must be evaluated using scientific methodology. Research is the key to maintaining focus on improving the overall health of the community in a competitive and cost-conscious health care market. Most importantly, research is essential to ensure that the best possible patient care is provided in the prehospital setting. The bravery and dedication of EMS professionals cannot be underestimated. Images of firefighters, EMS personnel, and others going into danger while others are evacuating will remain burned in our collective consciousness. These professionals deserve the benefit of research to assist them in providing the best possible care in the challenging circumstances they encounter. With this document, we are seeking support for elevating the science of EMS and prehospital care to the next level. It is essential that we examine innovative ways to deliver prehospital care. Strategies to protect the safety of both the patient and the public safety worker must be devised and tested. There are many questions that remain to be asked, many practices to be evaluated, and many procedures to be improved. Research is the key to obtaining the answers. PMID:12108581

  18. ......... em o Moscow, Idaho

    E-print Network

    O'Laughlin, Jay

    #12;#12;#12;#12;#12;......... em o #12;'"''!.. . ' I The UNIVERSITY of IDAHO Moscow, Idaho Editors Donald W. Samuelson, who strode purposefully out of the North, became Idaho's leading gentle- man will determine his place in Idaho history. Perhaps no governor of a Western state has more complex

  19. by EM tomography

    Microsoft Academic Search

    Peter König; Michael B. Braunfeld; John W. Sedat; David A. Agard

    We have studied the in vitro reconstitution of sperm nuclei and small DNA templates to mitotic chroma- tin in Xenopus laevis egg extracts by three-dimensional (3D) electron microscopy (EM) tomography. Using specif- ically developed software, the reconstituted chromatin was interpreted in terms of nucleosomal patterns and the overall chromatin connectivity. The condensed chromatin formed

  20. PROMETEUS FILOSOFIA EM REVISTA

    Microsoft Academic Search

    VIVA VOX; João Roberto Barros II; Marcos Antonio da Silva

    2010-01-01

    Resumo: O uso heurístico do conceito de natureza é importante para os propósitos concernentes à ideia de uma história como palco para o desenvolvimento das disposições originárias do ser humano. Esse argumento torna possível falar do desenvolvimento ativo das disposições originárias do ser humano sem ferir o núcleo crítico que marca a filosofia kantiana em seu período áureo. Nosso argumento

  1. Exercise metabolism in healthy volunteers taking celiprolol, atenolol, and placebo

    Microsoft Academic Search

    A Head; S Maxwell; M J Kendall

    1997-01-01

    OBJECTIVE: Previous studies have shown that beta 1 selective agents have fewer adverse effects on exercise metabolism than nonselective beta blockers, and this has been attributed to their reduced blockade of beta 2 receptors. This study aimed at determining whether a beta blocker with partial agonist activity at beta 1 and beta 2 receptors (celiprolol) was better than a conventional

  2. Gleevec disminuye la recidiva del cáncer en pacientes con tumor estromal gastrointestinal primario

    Cancer.gov

    Los resultados preliminares de un estudio clínico grande aleatorio y controlado con placebo, en pacientes con tumor estromal gastrointestinal (GIST) primario, un tipo de tumor que por lo general se encuentra en el estómago o en el intestino delgado, demostraron que los pacientes a los que se administró mesilato de imatinib (Gleevec®) luego de la extirpación total de su tumor tuvieron una probabilidad significativamente menor de padecer una recidiva del cáncer en comparación con aquellos a los que no se administró imatinib.

  3. The EM Earthquake Precursor

    NASA Astrophysics Data System (ADS)

    Jones, K. B., II; Saxton, P. T.

    2013-12-01

    Many attempts have been made to determine a sound forecasting method regarding earthquakes and warn the public in turn. Presently, the animal kingdom leads the precursor list alluding to a transmission related source. By applying the animal-based model to an electromagnetic (EM) wave model, various hypotheses were formed, but the most interesting one required the use of a magnetometer with a differing design and geometry. To date, numerous, high-end magnetometers have been in use in close proximity to fault zones for potential earthquake forecasting; however, something is still amiss. The problem still resides with what exactly is forecastable and the investigating direction of EM. After the 1989 Loma Prieta Earthquake, American earthquake investigators predetermined magnetometer use and a minimum earthquake magnitude necessary for EM detection. This action was set in motion, due to the extensive damage incurred and public outrage concerning earthquake forecasting; however, the magnetometers employed, grounded or buried, are completely subject to static and electric fields and have yet to correlate to an identifiable precursor. Secondly, there is neither a networked array for finding any epicentral locations, nor have there been any attempts to find even one. This methodology needs dismissal, because it is overly complicated, subject to continuous change, and provides no response time. As for the minimum magnitude threshold, which was set at M5, this is simply higher than what modern technological advances have gained. Detection can now be achieved at approximately M1, which greatly improves forecasting chances. A propagating precursor has now been detected in both the field and laboratory. Field antenna testing conducted outside the NE Texas town of Timpson in February, 2013, detected three strong EM sources along with numerous weaker signals. The antenna had mobility, and observations were noted for recurrence, duration, and frequency response. Next, two directional techniques were employed, resulting in three mapped, potential epicenters. The remaining, weaker signals presented similar directionality results to more epicentral locations. In addition, the directional results of the Timpson field tests lead to the design and construction of a third prototype antenna. In a laboratory setting, experiments were created to fail igneous rock types within a custom-designed Faraday Cage. An antenna emplaced within the cage detected EM emissions, which were both reproducible and distinct, and the laboratory results paralleled field results. With a viable system and continuous monitoring, a fracture cycle could be established and observed in real-time. Sequentially, field data would be reviewed quickly for assessment; thus, leading to a much improved earthquake forecasting capability. The EM precursor determined by this method may surpass all prior precursor claims, and the general public will finally receive long overdue forecasting.

  4. Evaluation of the mental foramen position in pediatric patients. Avaliação da posição do forame mentual em pacientes pediátricos

    Microsoft Academic Search

    Sidney Ricardo DOTTO; Edmundo MÉDICI FILHO; Luiz Cesar de MORAES; Carolina de Oliveira Tocaline; Walter PORTO; Patrícia Pasquali DOTTO

    The aim of the present study was to evaluate the location of the mental foramen, using panoramic x-rays from children with ages among ten to 12 years. In a first moment, the radiographs were digitalized and measures were accomplished in the Image Tool 1.27 software, being verified the distance between the mandible border and the mental foramen inferior portion, the

  5. Bioterrorism awareness for EMS.

    PubMed

    Patrick, Richard W

    2004-04-01

    It is important to understand that the issues surrounding bioterrorism and all weapons of mass destruction are complex. In an effort to enhance response to such events, EMS should handle all incidents from the perspective of an all-hazards approach. Prevention, preparation, response and recovery are essential to the safe mitigation of all incidents. Organizations must be prepared. Plan now for a safer tomorrow. Your personnel and communities depend on you. PMID:15131906

  6. UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM CINCIAS E TECNOLOGIAS EM SADE

    E-print Network

    Maier, Rudolf Richard

    1 UNIVERSIDADE DE BRASÍLIA PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS E TECNOLOGIAS EM SAÚDE EDITAL N. 01/2011 SELEÇÃO DE CANDIDATOS ÀS VAGAS DO PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS E TECNOLOGIAS EM. PREÂMBULO 1.1 A Coordenadora do Programa de Pós-Graduação em Ciências e Tecnologias em Saúde, no uso de suas

  7. MESTRADO EM MICROBIOLOGIA INOVAO, EMPREENDEDORISMO E TRANSFERNCIA DE TECNOLOGIA EM

    E-print Network

    Instituto de Sistemas e Robotica

    MESTRADO EM MICROBIOLOGIA INOVAÇÃO, EMPREENDEDORISMO E TRANSFERÊNCIA DE TECNOLOGIA EM MICROBIOLOGIA conceitos sobre os princípios e metodologias da moderna Transferência de Tecnologia. Assim, inclui-se numa alunos aprendem por realização real e directa do processo de transferência de tecnologia, utilizando

  8. Identified EM Earthquake Precursors

    NASA Astrophysics Data System (ADS)

    Jones, Kenneth, II; Saxton, Patrick

    2014-05-01

    Many attempts have been made to determine a sound forecasting method regarding earthquakes and warn the public in turn. Presently, the animal kingdom leads the precursor list alluding to a transmission related source. By applying the animal-based model to an electromagnetic (EM) wave model, various hypotheses were formed, but the most interesting one required the use of a magnetometer with a differing design and geometry. To date, numerous, high-end magnetometers have been in use in close proximity to fault zones for potential earthquake forecasting; however, something is still amiss. The problem still resides with what exactly is forecastable and the investigating direction of EM. After a number of custom rock experiments, two hypotheses were formed which could answer the EM wave model. The first hypothesis concerned a sufficient and continuous electron movement either by surface or penetrative flow, and the second regarded a novel approach to radio transmission. Electron flow along fracture surfaces was determined to be inadequate in creating strong EM fields, because rock has a very high electrical resistance making it a high quality insulator. Penetrative flow could not be corroborated as well, because it was discovered that rock was absorbing and confining electrons to a very thin skin depth. Radio wave transmission and detection worked with every single test administered. This hypothesis was reviewed for propagating, long-wave generation with sufficient amplitude, and the capability of penetrating solid rock. Additionally, fracture spaces, either air or ion-filled, can facilitate this concept from great depths and allow for surficial detection. A few propagating precursor signals have been detected in the field occurring with associated phases using custom-built loop antennae. Field testing was conducted in Southern California from 2006-2011, and outside the NE Texas town of Timpson in February, 2013. The antennae have mobility and observations were noted for recurrence, duration, and frequency response. At the Southern California field sites, one loop antenna was positioned for omni-directional reception and also detected a strong First Schumann Resonance; however, additional Schumann Resonances were absent. At the Timpson, TX field sites, loop antennae were positioned for directional reception, due to earthquake-induced, hydraulic fracturing activity currently conducted by the oil and gas industry. Two strong signals, one moderately strong signal, and approximately 6-8 weaker signals were detected in the immediate vicinity. The three stronger signals were mapped by a biangulation technique, followed by a triangulation technique for confirmation. This was the first antenna mapping technique ever performed for determining possible earthquake epicenters. Six and a half months later, Timpson experienced two M4 (M4.1 and M4.3) earthquakes on September 2, 2013 followed by a M2.4 earthquake three days later, all occurring at a depth of five kilometers. The Timpson earthquake activity now has a cyclical rate and a forecast was given to the proper authorities. As a result, the Southern California and Timpson, TX field results led to an improved design and construction of a third prototype antenna. With a loop antenna array, a viable communication system, and continuous monitoring, a full fracture cycle can be established and observed in real-time. In addition, field data could be reviewed quickly for assessment and lead to a much more improved earthquake forecasting capability. The EM precursors determined by this method appear to surpass all prior precursor claims, and the general public will finally receive long overdue forecasting.

  9. College of Engineering EM Engineering Mechanics

    E-print Network

    MacAdam, Keith

    College of Engineering EM Engineering Mechanics KEY: # = new course * = course changed = course or concur: MA 213. EM 302 MECHANICS OF DEFORMABLE SOLIDS. (3 of Engineering or consent of chairperson, and EM 221; prereq or concur: MA 214. EM 313 DYNAMICS. (3

  10. Programas del NCI: Análisis molecular para la elección de tratamientos (MATCH) y MATCH para pacientes infantiles

    Cancer.gov

    Información sobre el Programa de análisis molecular para la elección de tratamientos (MATCH) del NCI, el cual asignará pacientes con tumores sólidos y linfomas avanzados que hayan dejado de responder al tratamiento convencional a estudios clínicos de acuerdo con las anomalías genéticas de sus tumores.

  11. EPA LABORATORIES IMPLEMENT EMS PROGRAM

    EPA Science Inventory

    This paper highlights the breadth and magnitude of carrying out an effective Environmental Management System (EMS) program at the U.S. EPA's research and development laboratories. Federal research laboratories have unique operating challenges compared to more centralized industr...

  12. Spatial based Expectation Maximizing (EM)

    PubMed Central

    2011-01-01

    Background Expectation maximizing (EM) is one of the common approaches for image segmentation. Methods an improvement of the EM algorithm is proposed and its effectiveness for MRI brain image segmentation is investigated. In order to improve EM performance, the proposed algorithms incorporates neighbourhood information into the clustering process. At first, average image is obtained as neighbourhood information and then it is incorporated in clustering process. Also, as an option, user-interaction is used to improve segmentation results. Simulated and real MR volumes are used to compare the efficiency of the proposed improvement with the existing neighbourhood based extension for EM and FCM. Results the findings show that the proposed algorithm produces higher similarity index. Conclusions experiments demonstrate the effectiveness of the proposed algorithm in compare to other existing algorithms on various noise levels. PMID:22029864

  13. B-EM: A Classifier Incorporating Bootstrap with EM Approach for Data Mining

    E-print Network

    Wu, Xintao

    B-EM: A Classifier Incorporating Bootstrap with EM Approach for Data Mining Xintao Wu UNC that the more unlabeled examples are combined in learning, the more accurate the result. We then introduce B-EM

  14. El NCI inicia un estudio para evaluar la utilidad de la secuenciación genética para mejorar los resultados en los pacientes

    Cancer.gov

    El Instituto Nacional del Cáncer (NCI) lanzará este mes un estudio clínico piloto denominado M-PACT con la finalidad de evaluar si el tratamiento asignado según mutaciones genéticas específicas puede brindar beneficios a pacientes con tumores sólidos metastásicos.

  15. Anlise Comparativa entre rvores de Deciso e TRISS na Predio de Sobrevida de Pacientes Traumatizados

    E-print Network

    Baranauskas, José Augusto

    , Afonso Dinis Costa Passos2 , Domingos Alves2 , José Augusto Baranauskas1 1 Departamento de Física eAnálise Comparativa entre Árvores de Decisão e TRISS na Predição de Sobrevida de Pacientes Matemática Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto Universidade de São Paulo (USP

  16. Populações estelares em galáxias HII

    NASA Astrophysics Data System (ADS)

    Westera, P.; Cuisinier, F.; Telles, E.; Kehrig, C.

    2003-08-01

    Analisamos o conteúdo estelar de 74 galáxias HII a partir do contínuo observado nos espectros ópticos dessas galáxias, utilizando métodos de síntese de população estelar. Descobrimos que todas as galáxias para as quais encontramos soluções contêm uma população estelar velha que domina a massa estelar, e numa maioria dessas também encontramos evidência de uma população de idade intermediaria além da geração jovem que está se formando agora. Concluímos que a formação estelar dessas galáxias se realiza em surtos individuais, Esses surtos são interrompidos por longos períodos de inatividade, com os primeiros consumindo a maior parte do gás. Sugerimos, portanto, que as galáxias HII sejam galáxias anãs normais flagradas em um período de surto.

  17. REGIMENTO DO CURSO DE PS-GRADUAO EM ENGENHARIA E TECNOLOGIA ESPACIAIS, REA DE CONCENTRAO EM

    E-print Network

    REGIMENTO DO CURSO DE PÓS-GRADUAÇÃO EM ENGENHARIA E TECNOLOGIA ESPACIAIS, ÁREA DE CONCENTRAÇÂO EM Propulsão (PCP) do Curso de Pós-graduação em Engenharia e Tecnologia Espaciais (ETE) objetiva formar e de Pós-Graduação, pelo Regimento do Curso de Pós- Graduação em Engenharia e Tecnologia Espaciais e

  18. Burning the EMS candle. EMS shifts and worker fatigue.

    PubMed

    McCallion, R; Fazackerley, J

    1991-10-01

    Has coffee become your best friend? Do you sleep only in your dreams? Is your bed merely an illusion? If so, you are not alone; sleep deprivation is a fact of life for many EMS personnel. Though widely accepted, isn't it time that we question the effects of those long days and nights? PMID:10116022

  19. Instituto Brasileiro de Informao em Cincia e Tecnologia

    E-print Network

    Paraná, Universidade Federal do

    ibict Instituto Brasileiro de Informação em Ciência e Tecnologia OJS em uma Hora 1 OJS em uma hora Meinert ­ 06 de outubro de 2006 #12;ibict Instituto Brasileiro de Informação em Ciência e Tecnologia OJS Brasileiro de Informação em Ciência e Tecnologia OJS em uma Hora 3 Visão GeralVisão GeralVisão Geral

  20. EM 306 Statics ABET EC2000 syllabus

    E-print Network

    Ben-Yakar, Adela

    Edition Other Required Material: None Course Objectives: To be able to analyze systems of forcesEM 306 ­ Statics Page 1 ABET EC2000 syllabus EM 306 ­ Statics Fall and Spring 2009-10 Required Assignments: None Laboratory Projects: None #12;EM 306 ­ Statics Page 2 ABET EC2000 syllabus Contribution

  1. Project planning for EMS and SCADA systems

    Microsoft Academic Search

    Charles T. Lindeberg; Wayne R. Block

    1993-01-01

    A typical supervisory control and data acquisition (SCADA) system or an energy management system (EMS) has an installed life of only 10 to 15 years. Because it can take five years or more to implement a new EMS or SCADA system, managing such projects is becoming a way of life for utilities. Project planning for EMS and SCADA systems is

  2. Charge, from EM fields only

    E-print Network

    Collins, R L

    2006-01-01

    An electron is a purely electromagnetic particle, a PEP. The biggest problem has been charge. Most simply put, charge is a source or sink of E fields. A way to assemble EM fields into a stable configuration that exhibits charge and other particle properties has been found, based in part on Weber's interpretation of the Faraday homopolar generator. A dipolar B field, spinning about its symmetry axis, creates a radial vxB electric field that falls off as 1/r^2. This paper suggests that pair production involves the rearrangement of the EM fields of each half a photon. The EM fields then oscillate at the Compton frequency between a dipolar B field and a toroidal E field. Electric and magnetic flux are quantized. An electron has angular momentum, and so the EM field assembly is spinning. The 1/r^2 E=vxB electric field, created by the spinning dipolar B field, is strongest at the waist and zero at the poles. Precession of the spin axis about a different axis and with the same rate as spin, produces charge. Otherwis...

  3. WRF-EMS Aviation Products

    NSDL National Science Digital Library

    2014-09-14

    This lesson illustrates how numerical guidance from the Weather Research and Forecasting Model - Environmental Modeling System (WRF-EMS) can be added to surface observations, satellite graphics, and conceptual models of important aviation phenomena, to produce TAFs. Specifically, the lesson describes how visibility, cloud ceilings, and the flight categories variables provide values for aviation forecasts in Africa.

  4. CURSO DE ESPECIALIZAO EM FISIOTERAPIA

    E-print Network

    Floeter, Sergio Ricardo

    Bioquímica Fisiológica Medicina do Exercício em Pediatria Fisioterapia Respiratória Fisioterapia na Saúde ginecológica Nanotecnologia ­ Atualidades e Perspectivas Vinculadas à Tecnologia dos Materiais Biomecânica

  5. Correlation of the NBME Advanced Clinical Examination in EM and the National EM M4 exams

    PubMed Central

    Hiller, Katherine; Miller, Emily S.; Lawson, Luan; Wald, David; Beeson, Michael; Heitz, Corey; Morrissey, Thomas; House, Joseph; Poznanski, Stacey

    2015-01-01

    Introduction Since 2011 two online, validated exams for fourth-year emergency medicine (EM) students have been available (National EM M4 Exams). In 2013 the National Board of Medical Examiners offered the Advanced Clinical Examination in Emergency Medicine (EM-ACE). All of these exams are now in widespread use; however, there are no data on how they correlate. This study evaluated the correlation between the EM-ACE exam and the National EM M4 Exams. Methods From May 2013 to April 2014 the EM-ACE and one version of the EM M4 exam were administered sequentially to fourth-year EM students at five U.S. medical schools. Data collected included institution, gross and scaled scores and version of the EM M4 exam. We performed Pearson’s correlation and random effects linear regression. Results 303 students took the EM-ACE and versions 1 (V1) or 2 (V2) of the EM M4 exams (279 and 24, respectively). The mean percent correct for the exams were as follows: EM-ACE 74.8 (SD-8.83), V1 83.0 (SD-6.41), V2 78.5 (SD-7.70). Pearson’s correlation coefficient for the V1/EM-ACE was 0.51 (0.42 scaled) and for the V2/EM-ACE was 0.59 (0.41 scaled). The coefficient of determination for V1/EM-ACE was 0.72 and for V2/EM-ACE = 0.71 (0.86 and 0.49 for scaled scores). The R-squared values were 0.25 and 0.30 (0.18 and 0.13, scaled), respectively. There was significant cluster effect by institution. Conclusion There was moderate positive correlation of student scores on the EM-ACE exam and the National EM M4 Exams. PMID:25671023

  6. Mestrado e Doutorado em Filosofia edital 2014

    E-print Network

    Mestrado e Doutorado em Filosofia PUC-Rio edital 2014 O Departamento de Filosofia da Pontifícia Pós-graduação em Filosofia, nos níveis de mestrado e doutorado. Para a seleção de 2014, são oferecidas Filosofia; o candidato ao doutorado deverá ser mestre em Filosofia ou ter titulação equivalente. 1.3. Os

  7. Universidade de Braslia Programa de Ps-Graduao em Cincias e Tecnologias em Sade -PGCTS/FCE

    E-print Network

    Maier, Rudolf Richard

    Universidade de Brasília Programa de Pós-Graduação em Ciências e Tecnologias em Saúde - PGCTS/FCE Edital n. 01/2013 1 UNIVERSIDADE DE BRASÍLIA PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS E TECNOLOGIAS EM SAÚDE EDITAL Nº 01/2013 SELEÇÃO DE CANDIDATOS ÀS VAGAS DO PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS E TECNOLOGIAS

  8. CURSO DE PS-GRADUAO EM ENGENHARIA E TECNOLOGIA ESPACIAIS

    E-print Network

    CURSO DE PÓS-GRADUAÇÃO EM ENGENHARIA E TECNOLOGIA ESPACIAIS ÁREA DE CONCENTRAÇÃO EM COMBUSTÃO E TECNOLOGIA ESPACIAIS ÁREA DE CONCENTRAÇÃO EM COMBUSTÃO E PROPULSÃO Adaptação Obrigatórias para o mestrado PCP

  9. EM international activities. February 1997 highlights

    SciTech Connect

    NONE

    1997-02-01

    EM International Highlights is a brief summary of on-going international projects within the Department of Energy`s Office of Environmental Management (EM). This document contains sections on: Global Issues, activities in Western Europe, activities in central and Eastern Europe, activities in Russia, activities in Asia and the Pacific Rim, activities in South America, activities in North America, and International Organizations.

  10. School Budget Hold'em Facilitator's Guide

    ERIC Educational Resources Information Center

    Education Resource Strategies, 2012

    2012-01-01

    "School Budget Hold'em" is a game designed to help school districts rethink their budgeting process. It evolved out of Education Resource Strategies' (ERS) experience working with large urban districts around the country. "School Budget Hold'em" offers a completely new approach--one that can turn the budgeting process into a long-term visioning…

  11. Analysis of EM Channel of Producing Well

    Microsoft Academic Search

    Jintao Yu; Mingli Ding; Tingwei Liang

    2008-01-01

    Measurements while drilling (MWD) is a new technology by which we can observe the measurement values of the drilling parameters in the way of real-time. Use the results of searching the electromagnetic (EM) transmission channel for MWD for reference, an EM transmission model for the wireless transmission is set up. In addition, the model parameters are calculated by using the

  12. Em que medida devem ser privados, em que medida devem ser pblicos o conhecimento e a informao?

    E-print Network

    Kuhlen, Rainer

    Em que medida devem ser privados, em que medida devem ser públicos o conhecimento e a informação? 1 Transparências com licença Creative Commons Em que medida devem ser privados, em que medida devem ser públicos o as alternativas? codexKonstanz #12;Em que medida devem ser privados, em que medida devem ser públicos o

  13. Diseño y evaluación de un programa de seguimiento farmacoterapéutico a pacientes anticoagulados en atención primaria de salud

    Microsoft Academic Search

    MM Guerra García

    Resumen La incorporación del farmacéutico a los equipos de atención primaria en Galicia supone la implementación y desarrollo de programas de seguimiento farmacoterapéutico. El objetivo principal de este estudio fue dise- ñar y evaluar un programa de seguimiento farmacoterapéutico a pacientes anticoagulados; otros objetivos secundarios fueron los siguientes: 1. Establecer y cuantificar indicadores de seguimiento. 2. Registrar, cuantificar y clasificar

  14. Relação entre independência e o nível de disfunção motora e funcional em pacientes hemiparéticos Relation between functional independence and motor impairments in hemiparetic post-stroke patients

    Microsoft Academic Search

    Camila Torriani; Eliane Pires de Oliveira Mota; Sônia Hitomi; Pedrosa Kazurayama; Stella Ruhe Burin; Tatiana Mengatti; Juliana Caminho; Graziela Bastos; Jenifer Chris

    SUMMARY Objective: The purpose of this study is to verify the correlation between functional independence and motor impairments in hemiparetic post-stroke patients. Method: Twenty-three stroke patients were randomly selected. The exclusion criteria were severe cognitive dysfunction, comprehension aphasia and impossibility of participating. Before the patients signed the Consent Form, they were submitted to the Functional Independence Measure (FIM). The questionnaire

  15. Project X RFQ EM Design

    SciTech Connect

    Romanov, Gennady; /Fermilab; Hoff, Matthew; Li, Derun; Staples, John; Virostek, Steve; /LBNL

    2012-05-09

    Project X is a proposed multi-MW proton facility at Fermi National Accelerator Laboratory (FNAL). The Project X front-end would consist of an H- ion source, a low-energy beam transport (LEBT), a CW 162.5 MHz radio-frequency quadrupole (RFQ) accelerator, and a medium-energy beam transport (MEBT). Lawrence Berkeley National Laboratory (LBNL) and FNAL collaboration is currently developing the designs for various components in the Project X front end. This paper reports the detailed EM design of the CW 162.5 MHz RFQ that provides bunching of the 1-10 mA H- beam with acceleration from 30 keV to 2.1 MeV.

  16. EM International, July 1994, Volume 2

    SciTech Connect

    Not Available

    1994-10-01

    The Office of Environmental Management (EM) at the Department of Energy (DOE) is seeking out and leveraging foreign technology, data, and resources in keeping with EM`s mandate to protect public health and the environment through the safe and cost-effective remediation of the Department`s nuclear weapons sites. EM works closely with foreign governments, industry, and universities to obtain innovative environmental technologies, scientific and engineering expertise, and operations experience that will support EM`s objectives. Where appropriate, these international resources are used to manage the more urgent risks at our sites, secure a safe workplace, help build consensus on critical issues, and strengthen our technology development program. Through international agreements EM engages in cooperative exchange of information, technology, and individuals. Currently, we are managing agreements with a dozen countries in Europe, Latin America, and Asia. These agreements focus on environmental restoration, waste management, transportation of radioactive wastes, and decontamination and decommissioning. This publication contains the following articles: in situ remediation integrated program; in-situ characterization and inspection of tanks; multimedia environmental pollutant assessment system (MEPAS); LLNL wet oxidation -- AEA technology. Besides these articles, this publication covers: EU activities with Russia; technology transfer activities; and international organization activities.

  17. Ambiente e formação estelar em galáxias

    NASA Astrophysics Data System (ADS)

    Mateus, A., Jr.; Sodré, L., Jr.

    2003-08-01

    Estudamos o ambiente de galáxias com formação estelar inicialmente a partir de uma amostra limitada em volume proveniente do 2dF Galaxy Redshift Survey. Discriminamos as galáxias com formação estelar com base em distintas classes espectrais, utilizando para esta classificação as larguras equivalentes das linhas [OII]l3727 e Hd. O ambiente é caracterizado pela densidade espacial local de galáxias. Mostramos que a fração de galáxias com formação estelar é bastante reduzida em ambientes densos, enquanto a de galáxias passivas aumenta nestas regiões. Por outro lado, quando analisamos a fração de galáxias que apresentam um surto recente de formação estelar, notamos que ela independe do ambiente, sendo que em regiões mais densas alguns destes objetos apresentam distorções em sua morfologia. Estes resultados são confrontados com a análise da dependência ambiental da taxa de formação estelar, estimada pela emissão em Ha, de uma amostra extraída do Sloan Digital Sky Survey. Um declínio gradual da formação estelar também é observado nesta análise, sugerindo que as interações por efeitos de maré sejam responsáveis pela redução da formação estelar em ambientes densos através da remoção do reservatório de gás das galáxias. No entanto, estas interações também podem induzir surtos de formação estelar nas galáxias, além de peculiaridades morfológicas observadas nos objetos que habitam regiões mais densas.

  18. CURSO DE PS-GRADUAO EM ENGENHARIA E TECNOLOGIA ESPACIAIS

    E-print Network

    CURSO DE PÓS-GRADUAÇÃO EM ENGENHARIA E TECNOLOGIA ESPACIAIS ÁREA DE CONCENTRAÇÃO EM ENGENHARIA E PÓS-GRADUAÇÃO EM ENGENHARIA E TECNOLOGIA ESPACIAIS ÁREA DE CONCENTRAÇÃO EM ENGENHARIA E GERENCIAMENTO Tecnologia de Satélites petronio.souza@lit.inpe.br CSE-201-4 Introdução à Engenharia de Sistemas Espaciais

  19. CURSO DE PS-GRADUAO EM ENGENHARIA E TECNOLOGIA ESPACIAIS

    E-print Network

    CURSO DE PÓS-GRADUAÇÃO EM ENGENHARIA E TECNOLOGIA ESPACIAIS ÁREA DE CONCENTRAÇÃO EM ENGENHARIA E;2 CURSO DE PÓS-GRADUAÇÃO EM ENGENHARIA E TECNOLOGIA ESPACIAIS ÁREA DE CONCENTRAÇÃO EM ENGENHARIA E Tecnologia de Satélites petronio.souza@lit.inpe.br CSE-201-4 Introdução à Engenharia de Sistemas Espaciais

  20. Investigao em clulas estaminais no Biocant deu origem a cinco patentes em dois anos

    E-print Network

    Instituto de Sistemas e Robotica

    Investigação em células estaminais no Biocant deu origem a cinco patentes em dois anos, nos últimos dois anos, em cinco patentes, duas delas já licenciadas a empresas, disse à Lusa o vias de dar origem a um projeto empresarial" no âmbito do rastreio e criação de novos fármacos. As duas

  1. FACULDADE DE CEILNDIA CAMPUS UnB CEILNDIA PROGRAMA DE PS-GRADUAO EM CINCIAS E TECNOLOGIAS EM SADE

    E-print Network

    Lucero, Jorge Carlos

    1 FACULDADE DE CEILÂNDIA ­ CAMPUS UnB CEILÂNDIA PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS E TECNOLOGIAS TECNOLOGIAS EM SAÚDE PARA OS CURSOS DE MESTRADO ACADÊMICO E DOUTORADO PARA O PRIMEIRO PERÍODO LETIVO DE 2012 1. PREÂMBULO 1.1. A Coordenadora do Programa de Pós-Graduação em Ciências e Tecnologias em Saúde, no uso de

  2. EMS offshore. A new horizon for paramedics.

    PubMed

    Mallard, A S

    1991-10-01

    The difficulty in getting medical aid to offshore drilling platforms can be a source of life-threatening delays. Recently, some companies have charted new waters by actually stationing EMS crews on their rigs. PMID:10116023

  3. EM-dissertations completed in 2007

    E-print Network

    Franssen, Michael

    2007 #12;Virtual Thermo-Mechanical Prototyping of Microelectronics Devices Driel, W.D. van Advisors-90-9022179-3 EM research theme: Computational and Experimental Mechanics Thermomechanical fatigue failure

  4. Estudo em microondas do aprisionamento e precipitação de elétrons em explosões solares

    NASA Astrophysics Data System (ADS)

    Rosal, A. C.; Costa, J. E. R.

    2003-08-01

    Uma explosão solar é uma variação rápida e intensa do brilho que ocorre nas chamadas regiões ativas da atmosfera, constituídas por um plasma magnetizado com intensa indução magnética. Os modelos de explosões solares atuais, discutidos na literatura, apresentam características de aprisionamento e precipitação de elétrons em ambientes magnéticos simplificados. Neste trabalho, nos propusemos a separar a emissão dos elétrons aprisionados da emissão dos elétrons em precipitação apenas a partir da emissão em microondas, melhorando portanto o controle sobre o conjunto de parâmetros inferidos. A emissão em microondas da população em precipitação é bastante fraca e portanto da nossa base de dados de 130 explosões observadas pelo Rádio Polarímetro de Nobeyama, em sete freqüências, apenas para 32 foi possível separar as duas componentes de emissão com uma boa razão sinal/ruído. A partir de estudos das escalas de tempo das emissões devidas à variação gradual da emissão no aprisionamento e da variação rápida da emissão dos elétrons em precipitação foi possível obter a separação utilizando um filtro temporal nas emissões resultantes. Em nossa análise destas explosões estudamos os espectros girossincrotrônicos da emissão gradual, a qual associamos provir do topo dos arcos magnéticos e da emissão de variação rápida associada aos elétrons em precipitação. Estes espectros foram calculados e dos quais inferimos que a indução magnética efetiva do topo e dos pés foi em média, Btopo = 236 G e Bpés = 577 G, inferidas das freqüências de pico dos espectros em ntopo = 11,8 GHz e npés = 14,6 GHz com leve anisotropia (pequeno alargamento espectral). O índice espectral da distribuição não-térmica de elétrons d, inferido do índice espectral de fótons da emissão em regime opticamente fino, foi de dtopo = 3,3 e dpés = 3,9. Estes parâmetros são típicos da maioria das análises realizadas em ambiente único de emissão e a relação dos índices espectrais, dpés > dtopo prioriza as interpretações com difusão em ângulo de passo devida a colisões Coulombianas. Nesta difusão o déficit de elétrons energéticos na precipitação seria uma conseqüência natural da dependência em e-3/2 das colisões elétron-próton (onde e é a energia dos elétrons).

  5. Condições físicas em galáxias HII

    NASA Astrophysics Data System (ADS)

    Kehrig, C.; Telles, E.; Cuisinier, F.

    2003-08-01

    Galáxias HII são galáxias anãs de baixa luminosidade que apresentam alta taxa de formação estelar. Seus espectros são dominados por intensas linhas de emissão devido à fotoionização pela presença de um grande número de estrelas do tipo O e B. Nós apresentamos um catálogo espectrofotométrico de 111 galáxias HII observadas no telescópio 1.52m do ESO com o espectrógrafo Boller & Chivens. Determinamos propriedades estatísticas da amostra e derivamos condições físicas (temperatura eletrônica, densidade eletrônica) e abundâncias químicas. Para algumas galáxias, fomos também capazes de resolver espacialmente regiões de formação estelar individuais e determinar propriedades espectroscópicas para estas regiões separadamente, o que nos permitiu avaliar as flutuações das condições físico-químicas dentro das galáxias HII. Em particular, vimos que apesar das galáxias HII apresentarem formação estelar espalhada ao longo do corpo da galáxia, são objetos quimicamente homogêneos. A fim de estudar a evolução temporal dos objetos durante o tempo de vida das estrelas ionizantes construimos também alguns diagramas relacionando razões de linhas de emissão com a largura equivalente de Hb (EW(Hb)). Para interpretar tais diagramas utilizamos modelos de fotoionização para populações estelares integradas. Concluímos que as galáxias HII não correspondem a simples idéia de um burst instantâneo envolvido por um gás opaco aos fótons ionizantes e com densidade constante. As relações observadas entre razões de linhas e EW(Hb) podem ser melhor compreendidas se as galáxias HII apresentarem populações estelares mais velhas, que contribuem para o contínuo óptico observado.

  6. de energia elétrica em equipamentos de energia elétrica em equipamentos de energia elétrica em equipamentos de energia elétrica em equipamentos de energia elétrica em equipamentos utilizados em galpão de frangos de corte utilizados em galpão de frangos de corte utilizados em galpão de frangos de corte utilizados em galpão de frangos de corte utilizados em galpão de frangos de corte

    Microsoft Academic Search

    José E. P. Turco; Luiz F. S. A. Ferreira; Renato L. Furlan

    2 FCAV\\/UNESP. Fone: (16) 3209-2637 3 FCAV\\/UNESP. Fone: (16) 3209-2654 Resumo: Resumo: Resumo: Resumo: Resumo: Este trabalho teve por objetivo analisar o consumo e o custo da energia elétrica em um galpão comercial de frangos de corte, durante dois ciclos de criação, inverno e verão. Foram realizadas medidas de consumo dos ventiladores, nebulizadores, lâmpadas e comedouros durante o manejo de

  7. Tour of the Electromagnetic Spectrum (EMS) Videos

    NSDL National Science Digital Library

    Troy Benesch

    2009-01-01

    These videos introduce middle- and high school-age learners to the electromagnetic spectrum. The product consists of 8 animations including an introduction to electromagnetic waves and one animation for each wavelength of the EM spectrum (Radio, Microwave, Infrared, Visible, Ultraviolet, X-Rays and Gamma Rays). Each wavelength of the EM spectrum offers a construct to illustrate and teach about NASA sensors, missions, and science. Emphasis is placed on relevant science, such as lunar exploration, and hot science topics, such as climate change. The examples and narrative for each wavelength animation build on the learners’ prior knowledge then introduces examples from NASA missions. These examples explore the use of spectral analysis and visualizations that help scientists make discoveries about the world around us using EM waves.

  8. the rash eventually resolved. Atenolol and pantoprazole were reintroduced progressively along with zidovudine,

    E-print Network

    Samudrala, Ram

    this is the first reported lichenoid drug eruption in response to tenofovir. However, in Gilead 907, a phase III. Gilead Sciences Inc. Viread (tenofovir) product monograph. October 2003. Available at: http://gilead

  9. EM-ONE : an architecture for reflective commonsense thinking

    E-print Network

    Singh, Pushpinder, 1972-2006.

    2005-01-01

    This thesis describes EM-ONE, an architecture for commonsense thinking capable of reflective reasoning about situations involving physical, social, and mental dimensions. EM-ONE uses as its knowledge base a library of ...

  10. CURSO DE PS-GRADUAO EM ENGENHARIA E TECNOLOGIA ESPACIAIS

    E-print Network

    CURSO DE PÓS-GRADUAÇÃO EM ENGENHARIA E TECNOLOGIA ESPACIAIS ÁREA DE CONCENTRAÇÃO EM COMBUSTÃO E Mendonça do IAE/CTA, Univ. Pennsylvania, USA, 1997 #12;CURSO DE ENGENHARIA E TECNOLOGIA ESPACIAIS ÁREA DE

  11. ECE 341: Electromagnetic Fields I EM devices and systems

    E-print Network

    Schumacher, Russ

    in material media - Electromagnetic induction - Inductance - Magnetic energy Applications: - ElectronicsECE 341: Electromagnetic Fields I EM devices and systems - Can compute and analyze potentials compositions - Can evaluate capacitance, inductance, resistance, and conductance of EM structures - Understands

  12. População estelar jovem em galáxias irregulares próximas

    NASA Astrophysics Data System (ADS)

    Guimarães, T. A.; Telles, E.

    2003-08-01

    A análise do conteúdo estelar de galáxias próximas através da fotometria das suas estrelas resolvidas nos fornece informações importantes sobre a história de formação estelar e os processos de formação estelar em galáxias, que estão diretamente ligados ao estudo de evolução de galáxias. Quando nenhuma estrela puder ser resolvida o método mais poderoso consiste na análise do conteúdo estelar integrado das galáxias através das suas cores integradas em conjunto com informação espectroscópica que combinados com modelos de síntese evolutiva podem restringir simultaneamente a função de massa inicial (IMF) e a taxa de formação estelar (SFR). Nesse contexto, galáxias do tipo tardio, em particular, irregulares, são relevantes por várias razões: elas são objetos relativamente simples, com alta atividade de formação estelar e são objetos relativamente jovens (geralmente apresentam baixas abundâncias de elementos pesados e grande quantidade de gás). Apresentamos uma análise fotométrica de uma amostra de 7 galáxias do tipo tardio do universo local (NGC 2366, NGC 4395, NGC 4656, NGC 4214, NGC 4236, HOII, IC2574) que foram observadas com uma boa resolução espacial nas bandas B, V e R no telescópio Isaac Newton de 2.5m de Roque de los Muchachos nas Ilhas Canárias, Espanha. A distribuição espacial da população estelar jovem dessas galáxias é discutida sobre os pontos de vista dos íindices de cor integrados e dos seus diagramas cor magnitude, que comparados com isócronas teóricas, nos fornecem informações sobre os eventos de formação estelar, como por exemplo, indicações sobre a idade dos mesmos. As principais conclusões do trabalho podem ser resumidas em: (i) As galáxias irregulares possuem formação estelar recente (FE) espalhada ocorrendo nos últimos 50 Manos; (ii) A formação estelar em galáxias irregulares não é auto-propagante em escalas globais ( > 100 pc) ; (iii) A FE pode ser auto-regulável em escalas espaciais de poucas dezenas de parsec; (iv) As galáxias irregulares sofreram um evento principal de FE há 1010 anos atrás, o que implica que houve um momento na evolução do universo onde a maior parte das estrelas se formaram em galáxias.

  13. A emissão em 8mm e as bandas de Merrill-Sanford em estrelas carbonadas

    NASA Astrophysics Data System (ADS)

    de Mello, A. B.; Lorenz-Martins, S.

    2003-08-01

    Estrelas carbonadas possuem bandas moleculares em absorção no visível e, no infravermelho (IR) as principais características espectrais se devem a emissão de grãos. Recentemente foi detectada a presença de bandas de SiC2 (Merrill-Sanford, MS) em emissão sendo atribuída à presença de um disco rico em poeira. Neste trabalho analisamos uma amostra de 14 estrelas carbonadas, observadas no telescópio de 1.52 m do ESO em 4 regiões espectrais diferentes, a fim de detectar as bandas de MS em emissão. Nossa amostra é composta de estrelas que apresentam além da emissão em 11.3 mm, outra em 8 mm. Esta última emissão, não usual nestes objetos, tem sido atribuída ou a moléculas de C2H2, ou a um composto sólido ainda indefinido. A detecção de emissões de MS e aquelas no IR, simultaneamente, revelaria um cenário mais complexo que o habitualmente esperado para os ventos destes objetos. No entanto como primeiro resultado, verificamos que as bandas de Merrill-Sanford encontram-se em absorção, não revelando nenhuma conexão com a emissão a 8 mm. Assim, temos duas hipóteses: (a) a emissão a 8 mm se deve à molécula C2H2 ou (b) essa emissão é resultado da emissão térmica de grãos. Testamos a segunda hipótese modelando a amostra com grãos não-homogêneos de SiC e quartzo, o qual emite em aproximadamente 8mm. Este grão seria produzido em uma fase evolutiva anterior a das carbonadas (estrelas S) e por terem uma estrutura cristalina são destruídos apenas na presença de campos de radiação ultravioleta muito intensos. Os modelos para os envoltórios utilizam o método de Monte Carlo para descrever o problema do transporte da radiação. As conclusões deste trabalho são: (1) as bandas de Merrill-Sanford se encontram em absorção, sugerindo um cenário usual para os ventos das estrelas da amostra; (2) neste cenário, a emissão em 8 mm seria resultado de grãos de quartzo com mantos de SiC, indicando que o quartzo poderia sobreviver a fase evolutiva S.

  14. Marvin, robô construtor para competição em robótica móvel

    Microsoft Academic Search

    André Martin Narciso; Carlos Augusto; Bentes da Silva; Jackson Paul Matsuura

    renatohsp@gmail .com Resumo: Este artigo é sobre a construção do robô autônomo Marvin o Construtor, que foi construído para participar da IV Competição IEEE Brasileira de Robô. A tarefa consiste em empilhar blocos em uma área predeterminada em um menor tempo possível, ganha a torre mais alta. O robô, construído por alunos do Instituto Tecnológico de Aeronáutica (ITA), foi construído

  15. CURSO DE PS-GRADUAO EM ENGENHARIA E TECNOLOGIA ESPACIAIS

    E-print Network

    CURSO DE PÓS-GRADUAÇÃO EM ENGENHARIA E TECNOLOGIA ESPACIAIS ÁREA DE CONCENTRAÇÃO EM ENGENHARIA E ENGENHARIA E TECNOLOGIA ESPACIAIS ÁREA DE CONCENTRAÇÃO EM ENGENHARIA E GERENCIAMENTO DE SISTEMAS ESPACIAIS 1º Período Obrigatória para o Mestrado e o Doutorado CSE-200-4 Introdução à Tecnologia de Satélites otavio

  16. CURSO DE PS-GRADUAO EM ENGENHARIA E TECNOLOGIA ESPACIAIS

    E-print Network

    CURSO DE PÓS-GRADUAÇÃO EM ENGENHARIA E TECNOLOGIA ESPACIAIS ÁREA DE CONCENTRAÇÃO EM ENGENHARIA E TECNOLOGIA ESPACIAIS ÁREA DE CONCENTRAÇÃO EM ENGENHARIA E GERENCIAMENTO DE SISTEMAS ESPACIAIS 1º Período Obrigatória para o Mestrado e o Doutorado CSE-200-4 Introdução à Tecnologia de Satélites petronio

  17. CURSO DE PS-GRADUAO EM ENGENHARIA E TECNOLOGIA ESPACIAIS

    E-print Network

    CURSO DE PÓS-GRADUAÇÃO EM ENGENHARIA E TECNOLOGIA ESPACIAIS ÁREA DE CONCENTRAÇÃO EM ENGENHARIA E, ITA, Brasil, 1990 #12;2 CURSO DE PÓS-GRADUAÇÃO EM ENGENHARIA E TECNOLOGIA ESPACIAIS ÁREA DE Doutorado CSE-200-4 Introdução à Tecnologia de Satélites CSE-201-4 Introdução à Engenharia de Sistemas

  18. CURSO DE PS-GRADUAO EM ENGENHARIA E TECNOLOGIA ESPACIAIS

    E-print Network

    CURSO DE PÓS-GRADUAÇÃO EM ENGENHARIA E TECNOLOGIA ESPACIAIS ÁREA DE CONCENTRAÇÃO EM MECÂNICA TECNOLOGIA ESPACIAIS ÁREA DE CONCENTRAÇÃO EM MECÂNICA ESPACIAL E CONTROLE RELAÇÃO DAS DISCIPLINAS SEPARADAS Ciência, Engenharia e Tecnologia I CMC-325-3 Teoria de Visualização Gráfica Tridimensional I: Algoritmos

  19. CURSO DE PS-GRADUAO EM ENGENHARIA E TECNOLOGIA ESPACIAIS

    E-print Network

    CURSO DE PÓS-GRADUAÇÃO EM ENGENHARIA E TECNOLOGIA ESPACIAIS ÁREA DE CONCENTRAÇÃO EM CIÊNCIA E TECNOLOGIA DE MATERIAIS E SENSORES Coordenador Acadêmico do Curso Evandro Marconi Rocco Coordenador Acadêmico TECNOLOGIA ESPACIAIS ÁREA DE CONCENTRAÇÃO EM CIÊNCIA E TECNOLOGIA DE MATERIAIS E SENSORES 1o Período Letivo

  20. Development of Em18-immunoblot and Em18-ELISA for specific diagnosis of alveolar echinococcosis.

    PubMed

    Ito, Akira; Sako, Yasuhito; Yamasaki, Hiroshi; Mamuti, Wulamu; Nakaya, Kazuhiro; Nakao, Minoru; Ishikawa, Yuji

    2003-02-01

    Extensive experience has documented that Em2(plus)-ELISA, Em10-ELISA and Em18-immunoblot and Em18-ELISA are reliable serologic methods for detection of alveolar echinococcosis (AE) caused by the metacestodes of Echinococcus multilocularis. Among these, tests based on detection of antibodies to the specific Em18 antigen, either immunoblot or ELISA, appears to be the most specific for AE. Between 90 and 97% of AE cases with characteristic hepatic lesions detectable by image analysis have been positive in Em18-serology. In contrast Antigen B (8 kDa)-immunoblot is the most sensitive for all forms of echinococcosis, although it can not differentiate AE from cystic echinococcosis (CE). Primary serologic screening for echinococcosis, especially for CE using hydatid cyst fluid of Echinococcus granulosus appears to be highly sensitive in endemic areas. Glycoproteins (GPs) purified from cyst fluid of Taenia solium are highly specific for diagnosis of T. solium neuorcysticercosis (NCC). Using currently available antigens it is not difficult to differentiate these three larval cestodiases serologically. We recommend that (1) primary screening of CE in endemic areas should be carried out using hydatid cyst fluid of E. granulosus prepared from cysts in either sheep, human or mouse for immunoblot and from sheep or mouse for ELISA, (2) both primary screening and confirmation of AE in endemic areas should be carried out using Em18-ELISA, Em18-immunoblot or Em2(plus)-ELISA. Serodiagnosis in areas where both AE and CE are endemic, such as in China, should be carried out as a combination of (1) and (2), and (3) serology of NCC should be carried out using GP-ELISA or GP-immunoblot. All samples showing antibody to Em18 are exclusively from echinococcosis cases. There have been no false positive test reactions with sera from other diseases. Strongest Em18 responders are all from patients with AE but some weaker responses may be found in sera of persons with advanced complex lesions of CE. These highly reliable serodiagnostic methods using native, recombinant and synthetic antigens are briefly summarized and experiences with these methods in Japan is reviewed. We believe that use of these specific antigens in screening and confirmation programs for AE in Japan will improve specificity and reduce the confusion, anxiety and expense in persons whose sera give false positive reactions with crude echinococcal antigens. PMID:12606094

  1. Metodos Matematicos em Financas Junho -Agosto 2005

    E-print Network

    Zubelli, Jorge Passamani

    decimais (t = 5) usando truncamento (e.g. 1.23459 1.2345). Voce ´e capaz de conseguir as duas ra´izes com 5 d´igitos de precis~ao em tal aritm´etica? (b) Encontre a raiz de menor valor absoluto da equa

  2. Frmions ultra-frios em redes ticas

    E-print Network

    Liu, I-Shih

    Efeito Zeeman BEEE µ=-= )()( |S MS >>>> | >>>> | >>>> Na presença de um campo magnéticoNa presença de um campo Corrida em busca do antiferromagnetismo #12;Experimentos · Schneider et al. Science 322, 1520 (2008

  3. EMS Division Potential Benefits of Selected

    E-print Network

    Propulsion Systems have been Demonstrated Eg-Walters1: "In 1980 a 300 KW superconductive homopolar generator Homopolar Motors & Projections for Ship Propulsion Topics NOTE: Search for the interplay of technical disciplines!!!!! #12;EMS Division Homopolar Motor Outline ·Homopolar Motor Basics ·Homopolar Motor Technology

  4. GEOBULLETIN DEcEmBEr 16Th

    E-print Network

    Sheridan, Jennifer

    are requested! If you have a news item, a request, an announcement etc. email it to geodept@geology at the University of New South Wales, Sydney, Australia. #12;GEOBULLETIN DEcEmBEr 16Th , 2011 - 3 - 1) Relationship Australia. The North Pole region hosts the oldest fossil life on Earth, as stromatolites in carbonates

  5. Transportes em Revista.com Pas: Portugal

    E-print Network

    Instituto de Sistemas e Robotica

    veículos Toyota Prius Plug-in (automóvel híbrido cujas baterias também são alimentadas por tomada elétrica Comentar artigo Imprimir PDF Enviar a um amigo 09 -10 -2012 Toyota aposta no hidrogénio para ve ículos Plug-in em Paris 21 -08 -2012 Toyota lan ça novo Auris com motoriza ção híbrida 20 -08 -2012 MAN

  6. EM PROPAGATION IN JET ENGINE TURBINES

    Microsoft Academic Search

    Eric Walton; Jonathan Young; Jim Moore; Kyle Davis

    There is interest in the propagation of EM signals inside jet engine turbines for a number of reasons. Applications include radar scattering phenomenology and jet engine plasma plume formation studies. In our research, we are interested in the communication channel characteristics for micro-size wireless sensors attached to the turbine blades that measure parameters such as strain and temperature. Propagation measurements

  7. CURSO DE PS-GRADUAO EM ASTROFSICA

    E-print Network

    CURSO DE PÓS-GRADUAÇÃO EM ASTROFÍSICA Coordenador Acadêmico Cláudia Vilega Rodrigues Conselho de curso André de Castro Milone Cláudia Vilega Rodrigues José Carlos Neves de Araújo Odylio Denys de Aguiar, Doutor, INPE, 1995 Cláudia Vilega Rodrigues, Doutora, USP, 1997 Dennis Bessada, Doutor, INPE, 2010 Emília

  8. enhancem ent of em ission and absorption

    E-print Network

    Schaich, William L.

    Resonant enhancem ent of em ission and absorption using frequency selective surfaces investigate the infrared properties of frequency selective surfaces consisting of alum inum patches on silicon Elsevier Science B.V. All rights reserved. Keywords: Frequency selective surfaces; Absorption; Infrared 1.I

  9. DINÂMICA DA ESTRATÉGIA LOGÍSTICA EM EMPRESAS BRASILEIRAS

    Microsoft Academic Search

    Peter Fernandes Wanke

    RESUMO O objetivo do artigo é analisar a estratégia logística das empresas brasileiras a partir da mensuração do impacto de diferentes características do negócio sobre as principais decisões de produção e distribuição física de produtos acabados. Foi conduzida uma pesquisa de campo em empresas listadas no Ranking Exame para confrontar as quatro políticas propostas por Pagh e Cooper (1998), derivadas

  10. ESPÉCIES DO GÊNERO Eimeria (APICOMPLEXA: EIMERIIDAE) EM TAMANDUÁS-BANDEIRA (Myrmecophaga tridactyla LINNAEUS, 1758) EM CATIVEIRO

    Microsoft Academic Search

    FAGNER LUIZ DA C. FREITAS; ANDRÉ S. ZANETTI; CÉLIO R. MACHADO; ROSANGELA Z. MACHADO

    1 ABSTRACT:- FREITAS, F.L. DA C.; ALMEIDA, K. DE S.; ZANETTI, A.S.; NASCIMENTO, A.A. DO; MACHADO, C. R.; MACHADO, R.Z. (Species of the genus Eimeria (Apicomplexa: Eimeriidae) in giant anteaters (Myrmecophaga tridactyla Linnaeus, 1758) in captivity). Espécies do gênero Eimeria (Apicomplexa: Eimeriidae) em Tamanduás-bandeira (Myrmecophaga tridactyla Linnaeus, 1758) em cativeiro. Revista Brasileira de Parasitologia Veterinária, v. 15, n. 1, p.

  11. Marine EM in GOM: Advances and outlook

    NASA Astrophysics Data System (ADS)

    MacGregor, L. M.; Strack, K. M.

    2005-05-01

    Marine electromagnetic (EM) sounding methods provide valuable complementary information to conventional seismic exploration methods and success stories have been claimed by several oil companies: 1) as indicator of hydrocarbon presence derived from strong resistive anomalies 2) as complimentary tool in structural exploration. While 3D seismic identifies geological structures, it does not directly reveal the fluid content (hydrocarbons). Marine EM sounding exploits variations in electrical resistivity, and is directly sensitive to fluid saturation and thus resistive hydrocarbons. Under the right circumstances it can confirm the presence of hydrocarbons by identifying their resistive characteristics. This means that the possibility of drilling dry exploration wells is significantly reduced, as is the need for extensive appraisal drilling. EM data is used to resolve ambiguities in the structural interpretation of seismic data. For example, whereas the top of a diapiric salt body is often well constrained by seismic data, the position of the lower boundaries is often more elusive. Carbonate (or salt blankets, or resistive basalt) layers complicate the detection and characterization of deeper structure because of diffusive scattering in the layer. However, the resistivity contrast between these layers and the sediments below is an ideal target for EM sounding methods. Recently, two marine EM methods have become popular: The controlled source EM (CSEM) method and magnetotellurics (MT). The CSEM method uses an electric dipole source to transmit low frequency electromagnetic signals to an array of receivers that measure the electromagnetic field at the seafloor. Variation in amplitude and phase of the received signal as the source is towed through the receiver array yield the resistivity structure of the sub-surface to depths of several kilometers. The MT method uses naturally occurring electromagnetic source fields to determine the resistivity of the sub-surface. Thus, by studying the variation in response as a function of frequency, the variation in resistivity as a function of depth may be determined. These methods give complementary information about the resistivity structure of the sub-seafloor. Whereas CSEM data are primarily sensitive to resistive structures, and in particular to layers that are thin compared to their depth of burial, MT data can constrain larger scale conductive structure. By combining natural and controlled source methods better constraints on the geometry and properties of the seafloor can be gained than from either data type alone. Several case histories with large salt structures in the section illustrate that the techniques are useful for future exploration in the GOM. We see the technology moving from its present focus of deep water to include shallower water depths (where CSEM sounding is presently restricted). In addition, we envision the integration of complimentary EM techniques to get a better constrained resistivity image of the subsurface.

  12. BUSCA LOCAL PARA POS-PROCESSAMENTO EM RESULTADOS DE OTIMIZAC~AO MULTI-OBJETIVO EM REDES DE FILAS

    E-print Network

    Cruz, Frederico

    BUSCA LOCAL PARA P´OS-PROCESSAMENTO EM RESULTADOS DE OTIMIZA¸C~AO MULTI-OBJETIVO EM REDES DE FILAS otimiza¸c~ao de redes de filas finitas, a capacidade total do sistema em ´areas de espera deve ser a menor algoritmo simulated annealing foi desenvolvido, especialmente para redes de filas finitas, produzindo solu

  13. Modelling and design for PM/EM magnetic bearings

    NASA Technical Reports Server (NTRS)

    Pang, D.; Kirk, J. A.; Anand, D. K.; Johnson, R. G.; Zmood, R. B.

    1992-01-01

    A mathematical model of a permanent magnet/electromagnet (PM/EM) radially active bearing is presented. The bearing is represented by both a reluctance model and a stiffness model. The reluctance model analyzes the magnetic circuit of the PM/EM bearings. By combining the two models, the performance of the bearing can be predicted given geometric dimensions, permanent magnet strength, and the parameters of the EM coils. The overall bearing design including the PM and EM design is subject to the performance requirement and physical constraints. A study of these requirements and constraints is discussed. The PM design is based on the required magnetic flux for proper geometric dimensions and magnet strength. The EM design is based on the stability and force slew rate consideration, and dictates the number of turns for the EM coils and the voltage and current of the power amplifier. An overall PM/EM bearing design methodology is proposed and a case study is also demonstrated.

  14. Diseño de un programa de base de datos para el seguimiento de pacientes, aplicando el Real Decreto 1566\\/1998 sobre control de calidad en radioterapia

    Microsoft Academic Search

    José López Torrecilla; Desamparados González Sanchis; Ana Hernández Machancoses; Piedad Almendros Blanco; Enrique García Miragall; Eugenio López Taberner

    2004-01-01

    Resumen\\u000a Introducción  En julio de 1999, siguiendo el Real Decreto 1566\\/1998 y las normas ISO 9002, fue diseñado un programa informático para analizar\\u000a anualmente toxicidad, control de la enfermedad y supervivencia.\\u000a \\u000a \\u000a \\u000a Material y métodos  Se analizaron un total de 2.192 pacientes tratados en el Servicio de Oncología Radioterápica hasta mayo de 2005. El 51,8%\\u000a de los pacientes fueron estadios iniciales y el

  15. TandEM: Titan and Enceladus mission

    Microsoft Academic Search

    A. Coustenis; S. K. Atreya; T. Balint; R. H. Brown; M. K. Dougherty; F. Ferri; M. Fulchignoni; D. Gautier; R. A. Gowen; C. A. Griffith; L. I. Gurvits; R. Jaumann; Y. Langevin; M. R. Leese; J. I. Lunine; C. P. McKay; X. Moussas; I. Müller-Wodarg; F. Neubauer; T. C. Owen; F. Raulin; E. C. Sittler; F. Sohl; C. Sotin; G. Tobie; T. Tokano; E. P. Turtle; J.-E. Wahlund; J. H. Waite; K. H. Baines; J. Blamont; A. J. Coates; I. Dandouras; T. Krimigis; E. Lellouch; R. D. Lorenz; A. Morse; C. C. Porco; M. Hirtzig; J. Saur; T. Spilker; J. C. Zarnecki; E. Choi; N. Achilleos; R. Amils; P. Annan; D. H. Atkinson; Y. Bénilan; C. Bertucci; B. Bézard; G. L. Bjoraker; M. Blanc; L. Boireau; J. Bouman; M. T. Capria; E. Chassefière; P. Coll; M. Combes; J. F. Cooper; A. Coradini; F. Crary; T. Cravens; I. A. Daglis; E. de Angelis; C. de Bergh; I. de Pater; C. Dunford; G. Durry; O. Dutuit; D. Fairbrother; F. M. Flasar; A. D. Fortes; R. Frampton; M. Fujimoto; M. Galand; O. Grasset; M. Grott; T. Haltigin; A. Herique; F. Hersant; H. Hussmann; W. Ip; R. Johnson; E. Kallio; S. Kempf; M. Knapmeyer; W. Kofman; R. Koop; T. Kostiuk; N. Krupp; M. Küppers; H. Lammer; L.-M. Lara; P. Lavvas; S. Le Mouélic; S. Lebonnois; S. Ledvina; J. Li; T. A. Livengood; R. M. Lopes; J.-J. Lopez-Moreno; D. Luz; P. R. Mahaffy; U. Mall; J. Martinez-Frias; B. Marty; T. McCord; C. Menor Salvan; A. Milillo; D. G. Mitchell; R. Modolo; O. Mousis; M. Nakamura; C. D. Neish; C. A. Nixon; D. Nna Mvondo; G. Orton; M. Paetzold; J. Pitman; S. Pogrebenko; W. Pollard; O. Prieto-Ballesteros; P. Rannou; K. Reh; L. Richter; F. T. Robb; R. Rodrigo; S. Rodriguez; P. Romani; M. Ruiz Bermejo; E. T. Sarris; P. Schenk; B. Schmitt; N. Schmitz; D. Schulze-Makuch; K. Schwingenschuh; A. Selig; B. Sicardy; L. Soderblom; L. J. Spilker; D. Stam; A. Steele; K. Stephan; D. F. Strobel; K. Szego; C. Szopa; R. Thissen; M. G. Tomasko; D. Toublanc; H. Vali; I. Vardavas; V. Vuitton; R. A. West; R. Yelle; E. F. Young

    2009-01-01

    TandEM was proposed as an L-class (large) mission in response to ESA’s Cosmic Vision 2015–2025 Call, and accepted for further\\u000a studies, with the goal of exploring Titan and Enceladus. The mission concept is to perform in situ investigations of two worlds\\u000a tied together by location and properties, whose remarkable natures have been partly revealed by the ongoing Cassini–Huygens\\u000a mission. These

  16. Telescópio de patrulhamento solar em 12 GHz

    NASA Astrophysics Data System (ADS)

    Utsumi, F.; Costa, J. E. R.

    2003-08-01

    O telescópio de patrulhamento solar é um instrumento dedicado à observação de explosões solares com início de suas operações em janeiro de 2002, trabalhando próximo ao pico de emissão do espectro girossincrotrônico (12 GHz). Trata-se de um arranjo de três antenas concebido para a detecção de explosões e determinação em tempo real da localização da região emissora. Porém, desde sua implementação em uma montagem equatorial movimentada por um sistema de rotação constante (15 graus/hora) o rastreio apresentou pequenas variações de velocidade e folgas nas caixas de engrenagens. Assim, tornou-se necessária a construção de um sistema de correção automática do apontamento que era de fundamental importância para os objetivos do projeto. No segundo semestre de 2002 empreendemos uma série de tarefas com o objetivo de automatizar completamente o rastreio, a calibração, a aquisição de dados, controle de ganhos, offsets e transferência dos dados pela internet através de um projeto custeado pela FAPESP. O rastreio automático é realizado através de um inversor que controla a freqüência da rede de alimentação do motor de rastreio podendo fazer micro-correções na direção leste-oeste conforme os radiômetros desta direção detectem uma variação relativa do sinal. Foi adicionado também um motor na direção da declinação para correção automática da variação da direção norte-sul. Após a implementação deste sistema a precisão do rastreio melhorou para um desvio máximo de 30 segundos de arco, o que está muito bom para este projeto. O Telescópio se encontra em funcionamento automático desde março de 2003 e já conta com várias explosões observadas após a conclusão desta fase de automação. Estamos apresentando as explosões mais intensas do período e com as suas respectivas posições no disco solar.

  17. Helicopter EMS: Research Endpoints and Potential Benefits

    PubMed Central

    Thomas, Stephen H.; Arthur, Annette O.

    2012-01-01

    Patients, EMS systems, and healthcare regions benefit from Helicopter EMS (HEMS) utilization. This article discusses these benefits in terms of specific endpoints utilized in research projects. The endpoint of interest, be it primary, secondary, or surrogate, is important to understand in the deployment of HEMS resources or in planning further HEMS outcomes research. The most important outcomes are those which show potential benefits to the patients, such as functional survival, pain relief, and earlier ALS care. Case reports are also important “outcomes” publications. The benefits of HEMS in the rural setting is the ability to provide timely access to Level I or Level II trauma centers and in nontrauma, interfacility transport of cardiac, stroke, and even sepsis patients. Many HEMS crews have pharmacologic and procedural capabilities that bring a different level of care to a trauma scene or small referring hospital, especially in the rural setting. Regional healthcare and EMS system's benefit from HEMS by their capability to extend the advanced level of care throughout a region, provide a “backup” for areas with limited ALS coverage, minimize transport times, make available direct transport to specialized centers, and offer flexibility of transport in overloaded hospital systems. PMID:22203905

  18. TandEM: Titan and Enceladus mission

    USGS Publications Warehouse

    Coustenis, A.; Atreya, S.K.; Balint, T.; Brown, R.H.; Dougherty, M.K.; Ferri, F.; Fulchignoni, M.; Gautier, D.; Gowen, R.A.; Griffith, C.A.; Gurvits, L.I.; Jaumann, R.; Langevin, Y.; Leese, M.R.; Lunine, J.I.; McKay, C.P.; Moussas, X.; Muller-Wodarg, I.; Neubauer, F.; Owen, T.C.; Raulin, F.; Sittler, E.C.; Sohl, F.; Sotin, C.; Tobie, G.; Tokano, T.; Turtle, E.P.; Wahlund, J.-E.; Waite, J.H.; Baines, K.H.; Blamont, J.; Coates, A.J.; Dandouras, I.; Krimigis, T.; Lellouch, E.; Lorenz, R.D.; Morse, A.; Porco, C.C.; Hirtzig, M.; Saur, J.; Spilker, T.; Zarnecki, J.C.; Choi, E.; Achilleos, N.; Amils, R.; Annan, P.; Atkinson, D.H.; Benilan, Y.; Bertucci, C.; Bezard, B.; Bjoraker, G.L.; Blanc, M.; Boireau, L.; Bouman, J.; Cabane, M.; Capria, M.T.; Chassefiere, E.; Coll, P.; Combes, M.; Cooper, J.F.; Coradini, A.; Crary, F.; Cravens, T.; Daglis, I.A.; de Angelis, E.; De Bergh, C.; de Pater, I.; Dunford, C.; Durry, G.; Dutuit, O.; Fairbrother, D.; Flasar, F.M.; Fortes, A.D.; Frampton, R.; Fujimoto, M.; Galand, M.; Grasset, O.; Grott, M.; Haltigin, T.; Herique, A.; Hersant, F.; Hussmann, H.; Ip, W.; Johnson, R.; Kallio, E.; Kempf, S.; Knapmeyer, M.; Kofman, W.; Koop, R.; Kostiuk, T.; Krupp, N.; Kuppers, M.; Lammer, H.; Lara, L.-M.; Lavvas, P.; Le, Mouelic S.; Lebonnois, S.; Ledvina, S.; Li, J.; Livengood, T.A.; Lopes, R.M.; Lopez-Moreno, J. -J.; Luz, D.; Mahaffy, P.R.; Mall, U.; Martinez-Frias, J.; Marty, B.; McCord, T.; Salvan, C.M.; Milillo, A.; Mitchell, D.G.; Modolo, R.; Mousis, O.; Nakamura, M.; Neish, C.D.; Nixon, C.A.; Mvondo, D.N.; Orton, G.; Paetzold, M.; Pitman, J.; Pogrebenko, S.; Pollard, W.; Prieto-Ballesteros, O.; Rannou, P.; Reh, K.; Richter, L.; Robb, F.T.; Rodrigo, R.; Rodriguez, S.; Romani, P.; Bermejo, M.R.; Sarris, E.T.; Schenk, P.; Schmitt, B.; Schmitz, N.; Schulze-Makuch, D.; Schwingenschuh, K.; Selig, A.; Sicardy, B.; Soderblom, L.; Spilker, L.J.; Stam, D.; Steele, A.; Stephan, K.; Strobel, D.F.; Szego, K.; Szopa

    2009-01-01

    TandEM was proposed as an L-class (large) mission in response to ESA's Cosmic Vision 2015-2025 Call, and accepted for further studies, with the goal of exploring Titan and Enceladus. The mission concept is to perform in situ investigations of two worlds tied together by location and properties, whose remarkable natures have been partly revealed by the ongoing Cassini-Huygens mission. These bodies still hold mysteries requiring a complete exploration using a variety of vehicles and instruments. TandEM is an ambitious mission because its targets are two of the most exciting and challenging bodies in the Solar System. It is designed to build on but exceed the scientific and technological accomplishments of the Cassini-Huygens mission, exploring Titan and Enceladus in ways that are not currently possible (full close-up and in situ coverage over long periods of time). In the current mission architecture, TandEM proposes to deliver two medium-sized spacecraft to the Saturnian system. One spacecraft would be an orbiter with a large host of instruments which would perform several Enceladus flybys and deliver penetrators to its surface before going into a dedicated orbit around Titan alone, while the other spacecraft would carry the Titan in situ investigation components, i.e. a hot-air balloon (Montgolfi??re) and possibly several landing probes to be delivered through the atmosphere. ?? Springer Science + Business Media B.V. 2008.

  19. Gradientes de abundâncias em galáxias espirais

    NASA Astrophysics Data System (ADS)

    Dors, O. L.., Jr.; Copetti, M. V. F.

    2003-08-01

    Gradientes de abundâncias obtidos através de observações de regiões H II têm um papel importante no estudo de formação e evolução de galáxias espirais. Determinações diretas de abundâncias somente são obtidas quando linhas de emissão sensíveis à temperatura eletrônica (e.g., [O III]l4363) são detectadas. Infelizmente estas linhas são fracas ou não observadas em regiões H II de baixa excitação. Nestes casos métodos empíricos são utilizados para estimar as abundâncias químicas. Entretanto, diferentes métodos têm produzido diferentes estimativas de gradientes de abundâncias. Neste trabalho, nós construímos modelos de fotoionização com o objetivo de descrever diagramas de diagnósticos construídos com dados publicados de algumas galáxias espirais normais e barradas. Comparações entre nossas estimativas de abundâncias e de outros métodos mostram que quando não há acordo entre eles, nossos modelos superestimam as abundâncias de O/H e N/H por um fator de 0.3 dex em relação a estimativas diretas de abundâncias, e por fator de 0.2 dex em relação a outros métodos empíricos. A origem da produção de nitrogênio nas galáxias estudadas é discutida.

  20. MICORRIZA ARBUSCULAR EM ESPÉCIES ARBÓREAS NATIVAS DA BACIA DO RIO TIBAGI, PARANÁ

    Microsoft Academic Search

    Waldemar Zangaro; Silvio M. A. Nisizaki; Juliana C. B. Domingos; Emilia M. Nakano

    RESUMO: Relata-se a incidência da colonização de micorriza arbuscular (MA) e a resposta à inocu- lação em 81 espécies arbóreas nativas da bacia do rio Tibagi (PR), em condições de casa de vegetação. Também é relatada a incidência da colonização de MA em 51 espécies arbóreas nativas coletadas em áreas em início de sucessão arbórea e no interior da floresta

  1. Planificación de la transición a la atención en la etapa final de la vida para los pacientes con cáncer en estadio avanzado (PDQ®)

    Cancer.gov

    Resumen de información revisada por expertos sobre la preparación necesaria por parte de los proveedores de atención de la salud, los pacientes y sus familas para la transición a la etapa final de la vida en los casos de cáncer en estadio avanzado.

  2. Planificación de la transición a la atención en la etapa final de la vida para los pacientes de cáncer en estadio avanzado (PDQ®)

    Cancer.gov

    Resumen de información revisada por expertos sobre la preparación necesaria por parte de los proveedores de atención de la salud, los pacientes y sus familas para la transición a la etapa final de la vida en los casos de cáncer en estadio avanzado.

  3. An Effective EMS Hardware and Software Interface- The Trained Operator

    E-print Network

    Cherry, C. L.

    AN EFFECTIVE EMS HARDWARE AND SOFTWARE THE TRAINED OPER~TQR Christene ~. Cherry Johnson Controls Institute INTERFACE Milwaukee, ABSTRAC'l' A computerized Energy Management Sys tem (EMS) is a tool that allows the user to moni tor... and control building heating, ventilation, and air conditioning equip ment (HVAC). All computerized tools require three main components to function effectively: hardware, software, and an interface between the two - the operator. EMS owners recognize...

  4. UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM FILOSOFIA

    E-print Network

    Lucero, Jorge Carlos

    1 UNIVERSIDADE DE BRASÍLIA PROGRAMA DE P�S-GRADUA��O EM FILOSOFIA EDITAL No. 03/20011 SELE��O DE CANDIDATOS �S VAGAS DO PROGRAMA DE P�S-GRADUA��O EM FILOSOFIA: CURSO DE MESTRADO ACAD�MICO, PARA INGRESSO NO PRIMEIRO PERÍODO LETIVO DE 2012 PRE�MBULO O Coordenador do Programa de Pós-Graduação em Filosofia, no uso

  5. UNIVERSIDADE DE BRASLIA PROGRAMA DE PS GRADUAO EM FILOSOFIA

    E-print Network

    Maier, Rudolf Richard

    UNIVERSIDADE DE BRASÍLIA PROGRAMA DE P�S GRADUA��O EM FILOSOFIA EDITAL Nº 2/2012 SELE��O DE CANDIDATOS AO PROGRAMA DE P�S-GRADUA��O EM FILOSOFIA PARA O CURSO DE MESTRADO ACAD�MICO, PARA O PRIMEIRO PERIODO LETIVO DE 2013 1. PRE�MBULO 1.1 O Coordenador do Programa de Pós-Graduação em Filosofia, no uso de

  6. UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM FILOSOFIA

    E-print Network

    Maier, Rudolf Richard

    UNIVERSIDADE DE BRASÍLIA PROGRAMA DE P�S-GRADUA��O EM FILOSOFIA EDITAL Nº 1/2012 SELE��O DE CANDIDATOS AO PROGRAMA DE P�S-GRADUA��O EM FILOSOFIA PARA O CURSO DE MESTRADO ACAD�MICO, PARA INGRESSO NO SEGUNDO SEMESTRE LETIVO DE 2012 1. PRE�MBULO 1.1 O Coordenador do Programa de Pós-Graduação em Filosofia

  7. UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM FILOSOFIA

    E-print Network

    Maier, Rudolf Richard

    UNIVERSIDADE DE BRASÍLIA PROGRAMA DE P�S-GRADUA��O EM FILOSOFIA EDITAL No. 02/2010 SELE��O DE CANDIDATOS �S VAGAS DO PROGRAMA DE P�S-GRADUA��O EM FILOSOFIA PARA OS CURSOS DE MESTRADO ACAD�MICO PARA O PRIMEIRO SEMESTRE LETIVO DE 2011 PRE�MBULO O Coordenador do Programa de Pós-Graduação em Filosofia, no uso

  8. UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM FILOSOFIA

    E-print Network

    Lucero, Jorge Carlos

    1 UNIVERSIDADE DE BRASÍLIA PROGRAMA DE P�S-GRADUA��O EM FILOSOFIA EDITAL No. 02/20011 SELE��O DE CANDIDATOS �S VAGAS DO PROGRAMA DE P�S-GRADUA��O EM FILOSOFIA: CURSO DE MESTRADO ACAD�MICO, PARA INGRESSO NO PRIMEIRO PERÍODO LETIVO DE 2012 PRE�MBULO O Coordenador do Programa de Pós-Graduação em Filosofia, no uso

  9. 2. HI PAR (ACQUISITION RADAR) TOWER AND ENLISTED MEN (EM) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. HI PAR (ACQUISITION RADAR) TOWER AND ENLISTED MEN (EM) BARRACKS WITH RADAR ATTACHED. - Nike Hercules Missile Battery Summit Site, Battery Control Administration & Barracks Building, Anchorage, Anchorage, AK

  10. Recruitment and retention in rural and urban EMS: results from a national survey of local EMS directors.

    PubMed

    Freeman, Victoria A; Slifkin, Rebecca T; Patterson, P Daniel

    2009-01-01

    Maintaining an adequate staff is a challenge for rural emergency medical services (EMS) providers. This national survey of local EMS directors finds that rural EMS are more likely to be freestanding, that is, not affiliated with other public services, to employ only emergency medical technician-basics (EMT-Bs), and to be all volunteer. Rural EMS directors are more likely than urban ones to report that they are not currently fully staffed. The most common barriers to recruitment of EMTs in both urban and rural areas include unwillingness of community members to volunteer and lack of certified EMTs in the area. In rural areas, barriers to EMT training were noted more often than in urban areas as was the lack of employer support for employee volunteers. Similar rural training barriers affected retention of staff. Rural respondents reported that they lose staff to burnout and to difficulty in meeting continuing education requirements. Among rural respondents, those who direct all-volunteer EMS were the most likely to report recruitment and retention problems. The results suggest areas for further study including how volunteer EMS agencies can transition to paid agencies, how to bring EMS education to rural areas, and how EMS can work with other agencies to ensure EMS viability. PMID:19363405

  11. Marine EM Reference Database http://marineemlab.ucsd.edu/~kkey/MarineEM

    E-print Network

    Key, Kerry

    to document the peer-reviewed published papers that cover any aspect of marine electromagnetic induction. Techniques and instrumentation for study of natu- ral electromagnetic induction at sea. Physics Of The Earth. I started this database as part of a review paper that was presented at the 20th EM Induction

  12. Marine EM Reference Database http://marineemlab.ucsd.edu/~kkey/MarineEM

    E-print Network

    Key, Kerry

    to document the peer-reviewed published papers that cover any aspect of marine electromagnetic induction. I started this database as part of a review paper that was presented at the 20th EM Induction), Marine Electromagnetic Studies of Seafloor Resources and Tec- tonics, Surveys in Geophysics. http

  13. FORMAÇÃO EM E-BUSINESS PARA PME'S: UMA APROXIMAÇÃO BAS EADA EM E- LEARNING

    Microsoft Academic Search

    Sergio Castro; Nuno Caldeira; Eduardo Luís Cardoso

    Introdução Novas formas de desenvolvimen to das actividades empresariais, associadas a grandes ganhos de produtividade, têm emergido baseadas nos progressos permanentes das tecnologias de informação e comunicação (TIC) e nomeadamente da internet. A adopção das práticas de 'e -business' no tecido empresarial e o aparecimento de novas empresas baseadas nestes modelos tem sido bastante mais limitado na Europa em relação

  14. AVALIAÇÃO DA PRESENÇA DE ENDOSSIMBIONTES Cardinium em DIFERENTES ESPÉCIES DE ARTRÓPODES.

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A presença de endossimbiontes do gênero Cardinium em alguns grupos de artrópodes foi recentemente relatada e relacionada com diversas alterações reprodutivas em seus hospedeiros, tais como feminilização de ácaros, partenogênese em parasitóides, incompatibilidade citoplasmática e aumento da fecundida...

  15. EM threat analysis for wireless systems.

    SciTech Connect

    Burkholder, R. J. (Ohio State University Electroscience Laboratory); Mariano, Robert J.; Schniter, P. (Ohio State University Electroscience Laboratory); Gupta, I. J. (Ohio State University Electroscience Laboratory)

    2006-06-01

    Modern digital radio systems are complex and must be carefully designed, especially when expected to operate in harsh propagation environments. The ability to accurately predict the effects of propagation on wireless radio performance could lead to more efficient radio designs as well as the ability to perform vulnerability analyses before and after system deployment. In this report, the authors--experts in electromagnetic (EM) modeling and wireless communication theory--describe the construction of a simulation environment that is capable of quantifying the effects of wireless propagation on the performance of digital communication.

  16. Communication - An Effective Tool for Implementing ISO 14001/EMS

    SciTech Connect

    Rachel Damewood; Bowen Huntsman

    2004-04-01

    The Idaho National Engineering and Environmental Laboratory (INEEL) received ISO 14001/EMS certification in June 2002. Communication played an effective role in implementing ISO 14001/EMS at the INEEL. This paper describes communication strategies used during the implementation and certification processes. The INEEL achieved Integrated Safety Management System (ISMS) and Voluntary Protection Program (VPP) Star status in 2001. ISMS implemented a formal process to plan and execute work. VPP facilitated worker involvement by establishing geographic units at various facilities with employee points of contact and management champions. The INEEL Environmental Management System (EMS) was developed to integrate the environmental functional area into its ISMS and VPP. Since the core functions of ISMS, VPP, and EMS are interchangeable, they were easy to integrate. Communication is essential to successfully implement an EMS. (According to ISO 14001 requirements, communication interacts with 12 other elements of the requirements.) We developed communication strategies that integrated ISMS, VPP, and EMS. For example, the ISMS, VPP, and EMS Web sites communicated messages to the work force, such as “VPP emphasizes the people side of doing business, ISMS emphasizes the system side of doing business, and EMS emphasizes the systems to protect the environment; but they all define work, identify and analyze hazards, and mitigate the hazards.” As a result of this integration, the work force supported and implemented the EMS. In addition, the INEEL established a cross-functional communication team to assist with implementing the EMS. The team included members from the Training and Communication organizations, VPP office, Pollution Prevention, Employee and Media Relations, a union representative, facility environmental support, and EMS staff. This crossfunctional team used various communication strategies to promote our EMS to all organization levels and successfully implemented EMS activities through VPP geographic units. In summary, the ISMS and VPP process at the INEEL provided the basic framework of management support and worker involvement to implement our EMS. A cross-functional communication team was established to facilitate the implementation with great success. Communication has been an effective tool for implementing an ISO 14001/EMS at the INEEL.

  17. ANLISE DE DESEMPENHO E CONSUMO DE POTNCIA NA COMUNICAO INTERPROCESSOS EM SOFTWARE EMBARCADO

    E-print Network

    Wagner, Flávio Rech

    um microcontrolador Java de aplicação específica. Um sistema de controle embarcado de guindaste foi mensagens. Estes mecanismos foram avaliados em uma plataforma arquitetural baseada em um microcontrolador

  18. Sobre o uso das séries de Puiseux em mecanica celeste

    NASA Astrophysics Data System (ADS)

    Miloni, O. I.

    2003-08-01

    Neste trabalho é apresentada uma demonstração do uso dos diferentes desenvolvimentos em séries para as equações de perturbação em Mecânica Celeste no marco Hamiltoniano. Em trabalhos clássicos como os de Poincaré (Poincaré, 1893) por exemplo, já esta planteado o uso de potências não inteiras no pequeno parâmetro, o que evidencia a não analiticidade das funções quando uma ressonância ocorre. Nestes trabalhos os desenvolvimentos são na raíz quadrada da massa de Júpiter (o pequeno parâmetro). Mais recentemente (Ferraz-Mello, 1985) outros tipos de desenvolvimentos foram aplicados modificando substancialmente as ordens de grandeza e a velocidade de convergência das séries. Com esta abordagem, os desenvolvimentos foram expressados em termos da raíz cúbica do pequeno parâmetro. Neste trabalho apresentamos um enfoque geral, onde os diferentes tipos de desenvolvimentos em séries de Puiseux (Valiron, 1950) são obtidos a partir da aplicação de Teorema de Preparação de Weierstrass (Goursat, 1916) considerando a equação de Hamilton-Jacobi como uma equação algébrica. Os resultados são aplicados ao problema restrito dos três corpos em ressonância de primeira ordem e, dependendo da grandeza da excentricidade do asteróide em relação à de Júpiter, obtemos os diferentes desenvolvimentos, em raíz quadrada ou raíz cúbica da massa de Júpiter.

  19. EM algorithm for sparse representation-based image inpainting

    Microsoft Academic Search

    Mohamed-jalal Fadili; Jean-luc Starck

    2005-01-01

    We introduce an expectation-maximization (EM) algorithm for image inpainting based on a penalized likelihood formulated using linear sparse representations. Taking advantage of the sparsity of representations, a regularization through a prior penalty is imposed on the reconstructed coefficients. From a statistical point of view, the inpainting can be viewed as an estimation problem with missing data. The EM framework is

  20. MESTRADO EM MICROBIOLOGIA BIOLOGIA ESTRUTURAL Instituto Superior Tcnico

    E-print Network

    Instituto de Sistemas e Robotica

    MESTRADO EM MICROBIOLOGIA BIOLOGIA ESTRUTURAL ­ Instituto Superior Técnico Objectivos: Introduzir e/ou aprofundar técnicas avançadas de Análise Estrutural relevantes em Biologia e sua aplicação na elucidação de

  1. ELEKTRA: Um Chatterbot para Uso em Ambiente Educacional

    Microsoft Academic Search

    Michelle Denise Leonhardt; Daiane Dorneles de Castro; Liane Margarida; Rockenbach Tarouco

    2003-01-01

    **** Resumo. A E ducação à Distância vem despertando muito interesse de pesquisadores de diversas áreas. Por isso, também vem sendo muito a bordada em congressos, workshops e seminários. Muito se discute sobre a união entre tecnologia e educação visando complementar a formação de estudantes. Com a pesquisa em Inteligência Artificial, surgiram os chatterbots. Chatterbots são programas destinados a demonstrar

  2. APLICAÇÃO DO CONVERSOR ZETA EM fONTES CHAVEADAS

    Microsoft Academic Search

    Denizar Cruz Martins; Glaucio Nascimento de Abreu; Ivo Barbi

    RESUMO Pretende-se neste artigo estudar em regime permanente o desempenho do conversor ZETA em modo de operação contínuo. Este conversor é derivado do conversor Forward pela substituição do diodo retificador por um capacitor de acoplamento. Ábacos serão gerados para auxiliar no projeto da estrutura de potência. Os estudos teóricos são confirmados por simulação. São apresentados resultados experimentais obtidos a partir

  3. SALA DE AULA VIRTUAL EM INSTITUIÇÃO DE INTERNAÇÃO 1

    Microsoft Academic Search

    JANAINA ABDALLA

    2002-01-01

    Resumo: Este texto apresenta três interfaces de estudo: instituição disciplinar\\/ sociedade de controle, tecnologia da comunicação e da informação e educomunicação partir de um objeto de pesquisa: Sala de Aula Virtual em Instituição de Internação de Adolescente em conflito com a lei sob o regime de internação. Busca compreender a natureza da instituição e sua relação com o poder disciplinar,

  4. Using EM for Reinforcement Learning Peter Dayan Geoffrey E Hinton

    E-print Network

    Hinton, Geoffrey E.

    return, even though it can make large changes in the values of the parameters. The proof is based­maximization (EM) algorithm (Baum, Petrie, Soules & Weiss, 1970; Dempster, Laird & Rubin, 1977) and, as with EM . Our proof demonstrates that the RPP is well­founded. 2 Theory The RPP operates to improve

  5. BENJAMIN FRANKLIN E A HISTÓRIA DA ELETRICIDADE EM LIVROS DIDÁTICOS

    Microsoft Academic Search

    Cibelle Celestino Silva; Ana Carolina Pimentel

    Introdução Nos últimos anos, a história da ciência vem sendo introduzida em materiais didáticos utilizados em sala de aula. Uma das razões para isso é a pressão de órgãos governamentais, tais como a Secretaria de Educação Básica, responsável pela avaliação destes livros dentro do Programa Nacional de Livros Didáticos para o ens ino fundamental e médio. Os editais destes programas

  6. Dirio Econmico -Universidades Como ser investigador em Portugal

    E-print Network

    Instituto de Sistemas e Robotica

    Diário Económico - Universidades Como é ser investigador em Portugal Autor: N.D. Editora: ST e SF - Universidades Como é ser investigador em Portugal Autor: N.D. Editora: ST e SF Id: 1646658 Data Publicação: 19

  7. International EMS systems in South Africa: past, present, and future

    Microsoft Academic Search

    Campbell MacFarlane; Charl van Loggerenberg; Walter Kloeck

    2005-01-01

    Emergency medical services (EMS) in South Africa have developed rapidly over the last 20 years. However, there is inequitable distribution of services, with many rural areas being poorly resourced. This is partly as a result of the historical inequalities prevalent in the South African society of the past; efforts are being made to address this. EMS training is provided at

  8. RFID-based flexible low-cost EM field probe

    Microsoft Academic Search

    S. Capdevila; R. Serrano; A. Aguasca; S. Blanch; J. Romeu; L. Jofre

    2008-01-01

    The capability of the RFID tags as a low cost flexible device to measure the EM complex field distribution has been presented and some preliminary results presented. The devices do not need any kind of electrical connexion giving them a high versatility to act as a remote EM probing device under different conditions of positioning and accessibility. Sensitivity and dynamic

  9. Recent development in open systems for EMS\\/SCADA

    Microsoft Academic Search

    Yutaka Kokai; Fumio Masuda; Satoshi Horiike; Yasuji Sekine

    1998-01-01

    Based on the current situation and emerging trends of development of EMS\\/SCADA systems throughout the world, this report examines the `open system' concept from the viewpoints of users and suppliers. Current technologies for open distributed EMS\\/SCADAs and their possible future trends are described.

  10. A European Land Mobile Satellite System via EMS

    NASA Astrophysics Data System (ADS)

    Ananasso, Fulvio; Mistretta, Ignazio

    1991-10-01

    The paper analyzes the technical and market issues that influence the strategy of implementation of a Land Mobile Satellite System via the payload EMS (European Mobile System) embarked on ITALSAT F-2. The final goal is to determine services, network architecture, and added value chain that make LMSS via EMS profitable for a typical telecommunication company.

  11. The EM Algorithm and the Rise of Computational Biology

    Microsoft Academic Search

    Xiaodan Fan; Yuan Yuan; Jun S. Liu

    2009-01-01

    In the past decade, computational biology has grown from a cottage industry with a handful of researchers to an attractive in- terdisciplinary eld, catching the attention and imagination of many quantitatively-minded scientists. Of interest to us is the key role played by the EM algorithm during this transformation. We survey the use of the EM algorithm in a few important

  12. The EM Algorithm and the Rise of Computational Biology

    Microsoft Academic Search

    Xiaodan Fan; Yuan Yuan; Jun S. Liu

    2011-01-01

    In the past decade computational biology has grown from a cottage industry with a handful of researchers to an attractive interdisciplinary field, catching the attention and imagination of many quantitatively-minded scientists. Of interest to us is the key role played by the EM algorithm during this transformation. We survey the use of the EM algorithm in a few important computational

  13. EMS control chosen instead of refrigeration, HVAC upgrade

    Microsoft Academic Search

    1984-01-01

    A Wisconsin supermarket decided on the basis of costs to install an energy management system (EMS) to improve the store's energy efficiency rather than invest in new refrigerating equipment at this time. When the next remodeling occurs in two years, the store will purchase new equipment using energy savings from the EMS to help defray the costs. The store selected

  14. DOE EM industry programs robotics development

    SciTech Connect

    Staubly, R.; Kothari, V. [Dept. of Energy, Morgantown, WV (United States)

    1997-12-01

    The Office of Science and Technology (OST) manages an aggressive program for RD&D, as well as testing and evaluation for the U.S. Department of Energy`s (DOE) Environmental Management (EM) organization. The goal is to develop new and improved environmental restoration and waste management technologies to clean up the inventory of the DOE weapons complex faster, safer, and cheaper than is possible with currently available technologies. OST has organized technology management activities along focus teams for each major problem area. There are currently five focus areas: decontamination and decommissioning, tanks, subsurface contaminants, mixed waste, and plutonium. In addition, OST is pursuing research and development (R&D) that cuts across these focus areas by having applications in two or more focus areas. Currently, there are three cross-cutting programs: the robotics technology development; characterization, monitoring, and sensor technologies; and efficient separations and processing.

  15. Evaluation of Fracture Azimuth by EM Wave and Elastic Wave

    NASA Astrophysics Data System (ADS)

    Feng, X.; Wang, Q.; Liu, C.; Lu, Q.; Zeng, Z.; Liang, W.; Yu, Y.; Ren, Q.

    2013-12-01

    Fracture system plays an important role in the development of underground energy, for example enhanced geothermal system (EGS), oil shale and shale gas, etc. Therefore, it becomes more and more important to detect and evaluate the fracture system. Geophysical prospecting is an useful method to evaluate the characteristics of the subsurface fractures. Currently, micro-seismology, multi-wave seismic exploration, and electromagnetic (EM) survey are reported to be used for the purpose. We are studying a method using both elastic wave and EM wave to detect and evaluate the fracture azimuth in laboratory. First, we build a 3D horizontal transverse isotropy (HTI) model, shown in the figure 1, by dry parallel fractures system, which was constructed by plexiglass plates and papers. Then, we used the ultrasonic system to obtain reflected S-wave data. Depending on the shear wave splitting, we evaluated the fracture azimuth by the algorithm of Pearson correlation coefficient. In addition, we used the full Polarimetric ultra wide band electromagnetic (FP-UWB-EM) wave System, shown in the figure 2, to obtain full polarimetric reflected EM-wave data. Depending on the rotation of the EM wave polarimetry, we evaluated the fracture azimuth by the the ration between maximum amplitude of co-polarimetric EM wave and maximum amplitude of cross-polarimetric EM wave. Finally, we used both EM-wave data and S-wave data to evaluate the fracture azimuth by the method of cross plot and statistical mathematics. To sum up, we found that FP-UWB-EM wave can be used to evaluated the fracture azimuth and is more accurate than ultrasound wave. Also joint evaluation using both data could improve the precision.

  16. Queda dos homicídios em São Paulo, Brasil: uma análise descritiva

    PubMed Central

    Peres, Maria Fernanda Tourinho; Vicentin, Diego; Nery, Marcelo Batista; de Lima, Renato Sérgio; de Souza, Edinilsa Ramos; Cerda, Magdalena; Cardia, Nancy; Adorno, e Sérgio

    2012-01-01

    Objetivo Descrever a evolução da mortalidade por homicídios no Município de São Paulo segundo tipo de arma, sexo, raça ou cor, idade e áreas de exclusão/inclusão social entre 1996 e 2008. Métodos Estudo ecológico de série temporal. Os dados sobre óbitos ocorridos no Município foram coletados da base de dados do Programa de Aprimoramento das Informações sobre Mortalidade, seguindo a Classificação Internacional de Doenças, Décima Revisão (CID-10). Foram calculadas as taxas de mortalidade por homicídio (TMH) para a população total, por sexo, raça ou cor, faixa etária, tipo de arma e área de exclusão/inclusão social. As TMH foram padronizadas por idade pelo método direto. Foram calculados os percentuais de variação no período estudado. Para as áreas de exclusão/inclusão social foram calculados os riscos relativos de morte por homicídio. Resultados As TMH apresentaram queda de 73,7% entre 2001 e 2008. Foi observada redução da TMH em todos os grupos analisados, mais pronunciada em homens (?74,5%), jovens de 15 a 24 anos (?78,0%) e moradores de áreas de exclusão social extrema (?79,3%). A redução ocorreu, sobretudo, nos homicídios cometidos com armas de fogo (?74,1%). O risco relativo de morte por homicídio nas áreas de exclusão extrema (tendo como referência áreas com algum grau de exclusão social) foi de 2,77 em 1996, 3,9 em 2001 e 2,13 em 2008. Nas áreas de alta exclusão social, o risco relativo foi de 2,07 em 1996 e 1,96 em 2008. Conclusões Para compreender a redução dos homicídios no Município, é importante considerar macrodeterminantes que atingem todo o Município e todos os subgrupos populacionais e microdeterminantes que atuam localmente, influenciando de forma diferenciada os homicídios com armas de fogo e os homicídios na população jovem, no sexo masculino e em residentes em áreas de alta exclusão social. PMID:21390415

  17. UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM COMUNICAO

    E-print Network

    Maier, Rudolf Richard

    Experiência profissional em comunicação 5 Produção científica na área de comunicação (artigos, livros e capítulos) 10 Produção científica em outras áreas de conhecimento (artigos, livros e capítulos) 5 (artigos, livros e 10 #12;3 capítulos) Produção científica em outras áreas de conhecimento (artigos, livros

  18. EMS control chosen instead of refrigeration, HVAC upgrade

    SciTech Connect

    Watson, F.

    1984-05-07

    A Wisconsin supermarket decided on the basis of costs to install an energy management system (EMS) to improve the store's energy efficiency rather than invest in new refrigerating equipment at this time. When the next remodeling occurs in two years, the store will purchase new equipment using energy savings from the EMS to help defray the costs. The store selected an EMS with distributed processing that can expand to control new equipment. It expects a 22% drop in energy bills and a two-year payback of the $50,000 investment. Details of the system's functions describe some of the 53 control points.

  19. REGIMENTO DO CURSO DE PS-GRADUAO EM ENGENHARIA E TECNOLOGIA ESPACIAIS, REA DE CONCENTRAO

    E-print Network

    REGIMENTO DO CURSO DE PÓS-GRADUAÇÃO EM ENGENHARIA E TECNOLOGIA ESPACIAIS, ÁREA DE CONCENTRAÇÂO EM Espacial e Controle (CMC) do Curso de Pós-graduação em Engenharia e Tecnologia Espaciais (ETE) objetiva Conselho de Pós-Graduação, pelo Regimento do Curso de Pós-Graduação em Engenharia e Tecnologia Espaciais e

  20. REGIMENTO DO CURSO DE PS-GRADUAO EM ENGENHARIA E TECNOLOGIA ESPACIAIS, REA DE

    E-print Network

    REGIMENTO DO CURSO DE PÓS-GRADUAÇÃO EM ENGENHARIA E TECNOLOGIA ESPACIAIS, ÁREA DE CONCENTRAÇÃO EM Espacial e Controle (CMC) do Curso de Pós-graduação em Engenharia e Tecnologia Espaciais (ETE) objetiva de Pós-Graduação, pelo Regimento do Curso de Pós- Graduação em Engenharia e Tecnologia Espaciais e

  1. REGIMENTO DO CURSO DE PS-GRADUAO EM ENGENHARIA E TECNOLOGIA ESPACIAIS, REA DE

    E-print Network

    REGIMENTO DO CURSO DE PÓS-GRADUAÇÃO EM ENGENHARIA E TECNOLOGIA ESPACIAIS, ÁREA DE CONCENTRAÇÂO EM Espacial e Controle (CMC) do Curso de Pós-graduação em Engenharia e Tecnologia Espaciais (ETE) objetiva de Pós-Graduação, pelo Regimento do Curso de Pós- Graduação em Engenharia e Tecnologia Espaciais e

  2. Environmental Education and Development Division (EM-522). Annual report, Fiscal year 1993

    SciTech Connect

    Not Available

    1993-12-31

    The Environmental Education and Development Division (EM-522) is one of three divisions within the Office of Technology Integration and Environmental Education and Development (EM-52) in Environmental Restoration and Waste Management`s (EM`s) Office of Technology Development (EM-50). The primary design criterion for EM-522 education activities is directly related to meeting EM`s goal of environmental compliance on an accelerated basis and cleanup of the 1989 inventory of inactive sites and facilities by the year 2019. Therefore, EM-522`s efforts are directed specifically toward stimulating knowledge and capabilities to achieve the goals of EM while contributing to DOE`s overall goal of increasing scientific, mathematical, and technical literacy and competency. This report discusses fiscal year 1993 activities.

  3. MESTRADO EM MICROBIOLOGIA BIOTECNOLOGIA AMBIENTAL Instituto Superior Tcnico

    E-print Network

    Instituto de Sistemas e Robotica

    MESTRADO EM MICROBIOLOGIA BIOTECNOLOGIA AMBIENTAL ­ Instituto Superior Técnico Objectivos: Na risco ambiental), e sobre a aplicação de métodos da biotecnologia na resolução de problemas ambientais, desde a monitorização dos poluentes no Ambiente até à biorremediação nos compartimentos ambientais

  4. E.M. and Hadronic Shower Simulation with FLUKA

    SciTech Connect

    Battistoni, G.; Fasso, A.; Ferrari, A.; Ranft, J.; Rubbia, A.; Sala, P.R.; /INFN, Milan /SLAC /CERN /Siegen U. /Zurich, ETH

    2005-10-03

    A description of the main features of e.m. and hadronic shower simulation models used in the FLUKA code is summarized and some recent applications are discussed. The general status of the FLUKA project is also reported.

  5. Comparison of different marine EM methods for reservoir monitoring

    NASA Astrophysics Data System (ADS)

    ENDO, M.; Black, N.; Wilson, G. A.; Zhdanov, M. S.

    2011-12-01

    Recent studies have inferred the feasibility of controlled-source electromagnetic (CSEM) methods for the monitoring of offshore oil and gas fields. These studies have focused on CSEM methods where a transmitter is towed above an array of seafloor receivers. Recently, a towed streamer EM system capable to simultaneous seismic and CSEM data acquisition has been developed and tested in the North Sea. In this paper, we use 3D modeling and inversion to compare conventional CSEM with towed EM for monitoring of the Harding field, which is representative of a typical North Sea target. The 3D model of the Harding field itself was constructed from dynamic reservoir simulations. We observe similarities in the recovered models, suggesting that the towed streamer EM system could be used for reservoir monitoring. Obviating the need for ocean bottom receivers, the towed-streamer EM system enables CSEM data to be acquired simultaneously with seismic for higher production rates and relatively lower cost than conventional CSEM.

  6. EM 1110-2-2100 1 December 2005

    E-print Network

    US Army Corps of Engineers

    -3 Shear Strength Tests..................................................................... 2-8 2-3 Selection of Design Shear Strengths............................................. 2-9 2-5 Multiple Wedge Bearing Capacity........................................................... 3-10 3-6 #12;EM 1110-2-2100 1

  7. ISSN 0103-9741 Monografias em Cincia da Computao

    E-print Network

    Endler, Markus

    suscetibilidade, isto é, mapas que indi- cam localizações com riscos de deslizamento em uma dada área e que usa o é demonstrado por um estudo de caso onde o sistema possui a responsabilidade de gerar mapas de

  8. Nobel da Medicina em debate sobre a importncia da cincia

    E-print Network

    Instituto de Sistemas e Robotica

    Nobel da Medicina em debate sobre a importância da ciência lisboa O Nobel da Medicina e atual presidente da Royal Society (a congénere britânica da Acade- mia das Ciências) , Paul Nurse, está hoje em Lisboa para falar de ciên- cia e da forma como ela pode ser eficaz e imprescindível nas socie- dades

  9. Decentralized autonomous object-oriented EMS\\/SCADA system

    Microsoft Academic Search

    Toshibumi. Seki; H. Sato; T. Tanaka; H. Watanabe

    1997-01-01

    Energy management systems\\/supervisory control and data acquisition (EMS\\/SCADA) systems are usually geographically distributed and have operational organizations. They are changing in accordance with the various and varying environments, and they should be flexible enough to adapt to those changes quickly. The paper proposes a new architecture called SCOPE (System Configuration of Power Control System) to realize flexible and reliable EMS\\/SCADA

  10. NASA EM Followup of LIGO-Virgo Candidate Events

    NASA Technical Reports Server (NTRS)

    Blackburn, Lindy L.

    2011-01-01

    We present a strategy for a follow-up of LIGO-Virgo candidate events using offline survey data from several NASA high-energy photon instruments aboard RXTE, Swift, and Fermi. Time and sky-location information provided by the GW trigger allows for a targeted search for prompt and afterglow EM signals. In doing so, we expect to be sensitive to signals which are too weak to be publicly reported as astrophysical EM events.

  11. Maximum likelihood noise cancellation using the EM algorithm

    Microsoft Academic Search

    MEIR FEDER; ALAN V. OPPENHEIM; EHUD WEINSTEIN

    1989-01-01

    An approach to the two-microphone speech enhancement problem is discussed. Specifically, a maximum-likelihood (ML) problem is formulated for estimating the parameters needed for canceling the noise, and solved by the iterative EM (estimate-maximize) technique. The EM algorithm has been implemented for both a simplified and a more general scenario. The results improve upon those obtained with the classical least-squares approach

  12. Waste fuel, EMS may save plant $1M yearly

    Microsoft Academic Search

    Barber

    1982-01-01

    A mixture of paper trash and coal ash fueling an Erie, Pa. General Electric plant and a Network 90 microprocessor-based energy-management system (EMS) to optimize boiler efficiency will cost about $3 million and have a three-to-four-year payback. Over half the savings will come from the avoided costs of burning plant-generated trash. The EMS system will monitor fuel requirements in the

  13. EM Telemetry Tool for Deep Well Drilling Applications

    SciTech Connect

    Jeffrey M. Gabelmann

    2005-11-15

    This final report discusses the successful development and testing of a deep operational electromagnetic (EM) telemetry system, produced under a cooperative agreement with the United States Department of Energy's National Energy Technology Laboratory. This new electromagnetic telemetry system provides a wireless communication link between sensors deployed deep within oil and gas wells and data acquisition equipment located on the earth's surface. EM based wireless telemetry is a highly appropriate technology for oil and gas exploration in that it avoids the need for thousands of feet of wired connections. In order to achieve the project performance objectives, significant improvements over existing EM telemetry systems were made. These improvements included the development of new technologies that have improved the reliability of the communications link while extending operational depth. A key element of the new design is the incorporation of a data-fusion methodology which enhances the communication receiver's ability to extract very weak signals from large amounts of ambient environmental noise. This innovative data-fusion receiver based system adapts advanced technologies, not normally associated with low-frequency communications, and makes them work within the harsh drilling environments associated with the energy exploration market. Every element of a traditional EM telemetry system design, from power efficiency to reliability, has been addressed. The data fusion based EM telemetry system developed during this project is anticipated to provide an EM tool capability that will impact both onshore and offshore oil and gas exploration operations, for conventional and underbalanced drilling applications.

  14. DOE EM industry programs robotics development

    SciTech Connect

    Staubly, R.; Kothari, V.

    1998-12-31

    The Office of Science and Technology (OST) manages an aggressive program for RD and D, as well as testing and evaluation for the Department of Energy`s (DOE`s) Environmental Management (EM) organization. The goal is to develop new and improved environmental restoration and waste management technologies to clean up the inventory of the DOE weapons complex faster, safer, and cheaper than is possible with currently available technologies. Robotic systems reduce worker exposure to the absolute minimum, while providing proven, cost-effective, and, for some applications, the only acceptable technique for addressing challenging problems. Development of robotic systems for remote operations occurs in three main categories: tank waste characterization and retrieval; decontamination and dismantlement; and characterization, mapping, and inspection systems. In addition, the Federal Energy Technology Center (FETC) has some other projects which fall under the heading of supporting R and D. The central objective of all FETC robotic projects is to make robotic systems more attractive by reducing costs and health risks associated with the deployment of robotic technologies in the cleanup of the nuclear weapons complex. This will be accomplished through development of robots that are cheaper, faster, safer, and more reliable, as well as more straightforward to modify/adapt and more intuitive to operate with autonomous capabilities and intelligent controls that prevent accidents and optimize task execution.

  15. A eficiência de formação estelar em Musca

    NASA Astrophysics Data System (ADS)

    Hickel, G. R.; Vilas-Boas, J. W. S.; Roberto, A. J.., Jr.; Khan, R. P.

    2003-08-01

    Apresentamos os resultados de um survey no infravermelho próximo (bandas J e H), executado no Laboratório Nacional de Astrofísica, na direção da nuvem escura em forma de filamento de Musca (observamos ao longo de todo o filamento, além de todas as fontes pontuais IRAS e/ou fontes ROSAT brilhantes a uma distância de 2o da nuvem). Nosso objetivo é determinar a eficiência de formação estelar para esta nuvem escura (massa de estrelas formadas/massa da nuvem), procurando por objetos estelares jovens de pequena massa no seu interior e/ou evoluídos o suficiente para estarem afastados do local de nascimento, mas ainda mostrando características de objetos pré-seqüência principal como emissão de raios-X e excesso de emissão no infravermelho próximo. Este survey não estabeleceu nenhum viés na seleção de fontes pontuais IRAS ou fontes ROSAT, uma vez que a imensa maioria das fontes pontuais IRAS nesta região têm qualidade de fluxo ruim. Os candidatos a objetos estelares jovens foram selecionados pelo excesso no índice de cor (J-H), descontados os efeitos da extinção interestelar na linha de visada, determinada através da emissão estendida no infravermelho distante (IRAS). Estimativas de massa foram feitas para estes candidatos, através da relação massa-luminosidade, para calcular a eficiência de formação estelar de Musca.

  16. FitEM2EM--tools for low resolution study of macromolecular assembly and dynamics.

    PubMed

    Frankenstein, Ziv; Sperling, Joseph; Sperling, Ruth; Eisenstein, Miriam

    2008-01-01

    Studies of the structure and dynamics of macromolecular assemblies often involve comparison of low resolution models obtained using different techniques such as electron microscopy or atomic force microscopy. We present new computational tools for comparing (matching) and docking of low resolution structures, based on shape complementarity. The matched or docked objects are represented by three dimensional grids where the value of each grid point depends on its position with regard to the interior, surface or exterior of the object. The grids are correlated using fast Fourier transformations producing either matches of related objects or docking models depending on the details of the grid representations. The procedures incorporate thickening and smoothing of the surfaces of the objects which effectively compensates for differences in the resolution of the matched/docked objects, circumventing the need for resolution modification. The presented matching tool FitEM2EMin successfully fitted electron microscopy structures obtained at different resolutions, different conformers of the same structure and partial structures, ranking correct matches at the top in every case. The differences between the grid representations of the matched objects can be used to study conformation differences or to characterize the size and shape of substructures. The presented low-to-low docking tool FitEM2EMout ranked the expected models at the top. PMID:18974836

  17. Degradation of Benzodiazepines after 120 Days of EMS Deployment

    PubMed Central

    McMullan, Jason T.; Jones, Elizabeth; Barnhart, Bruce; Denninghoff, Kurt; Spaite, Daniel; Zaleski, Erin; Silbergleit, Robert

    2014-01-01

    Introduction EMS treatment of status epilepticus improves outcomes, but the benzodiazepine best suited for EMS use is unclear, given potential high environmental temperature exposures. Objective To describe the degradation of diazepam, lorazepam, and midazolam as a function of temperature exposure and time over 120 days of storage on active EMS units. Methods Study boxes containing vials of diazepam, lorazepam, and midazolam were distributed to 4 active EMS units in each of 2 EMS systems in the southwestern United States during May–August 2011. The boxes logged temperature every minute and were stored in EMS units per local agency policy. Two vials of each drug were removed from each box at 30-day intervals and underwent high-performance liquid chromatography to determine drug concentration. Concentration was analyzed as mean (and 95%CI) percent of initial labeled concentration as a function of time and mean kinetic temperature (MKT). Results 192 samples were collected (2 samples of each drug from each of 4 units per city at 4 time-points). After 120 days, the mean relative concentration (95%CI) of diazepam was 97.0% (95.7–98.2%) and of midazolam was 99.0% (97.7–100.2%). Lorazepam experienced modest degradation by 60 days (95.6% [91.6–99.5%]) and substantial degradation at 90 days (90.3% [85.2-95.4%]) and 120 days (86.5% [80.7–92.3%]). Mean MKT was 31.6°C (95%CI 27.1–36.1). Increasing MKT was associated with greater degradation of lorazepam, but not midazolam or diazepam. Conclusions Midazolam and diazepam experienced minimal degradation throughout 120 days of EMS deployment in high-heat environments. Lorazepam experienced significant degradation over 120 days and appeared especially sensitive to higher MKT exposure. PMID:24548058

  18. The EM-POGO: A simple, absolute velocity profiler

    NASA Astrophysics Data System (ADS)

    Terker, S. R.; Sanford, T. B.; Dunlap, J. H.; Girton, J. B.

    2013-01-01

    Electromagnetic current instrumentation has been added to the Bathy Systems, Inc. POGO transport sondes to produce a free-falling absolute velocity profiler called EM-POGO. The POGO is a free-fall profiler that measures a depth-averaged velocity using GPS fixes at the beginning and end of a round trip to the ocean floor (or a preset depth). The EM-POGO adds a velocity profile determined from measurements of motionally induced electric fields generated by the ocean current moving through the vertical component of the Earth's magnetic field. In addition to providing information about the vertical structure of the velocity, the depth-dependent measurements improve transport measurements by correcting for the non-constant fall-rate. Neglecting the variable fall rate results in errors O (1 cm s-1). The transition from POGO to EM-POGO included electrically isolating the POGO and electric-field-measuring circuits, installing a functional GPS receiver, finding a pressure case that provided an optimal balance among crush-depth, price and size, and incorporating the electrodes, electrode collar, and the circuitry required for the electric field measurement. The first EM-POGO sea-trial was in July 1999. In August 2006 a refurbished EM-POGO collected 15 absolute velocity profiles; relative and absolute velocity uncertainty was ˜1cms-1 and 0.5-5 cm s-1, respectively, at a vertical resolution of 25 m. Absolute velocity from the EM-POGO compared to shipboard ADCP measurements differed by ˜ 1-2 cm s-1, comparable to the uncertainty in absolute velocity from the ADCP. The EM-POGO is thus a low-cost, easy to deploy and recover, and accurate velocity profiler.

  19. Efeito preventivo da fisioterapia na redução da incidência de quedas em pacientes com Doença de Alzheimer Preventive effect of the physical therapy to minimize the occurrence of falls in patients with Alzheimer's Disease

    Microsoft Academic Search

    Tetsadê CB Piermartiri; Naaraí Camboim Bezerra; Alexandre Ademar Hoeller

    SUMMARY The purpose of this review is to provide better understanding of the preventive effect resulted by the Physical Therapy in- tervention to minimize the occurrence of falls in patients with Alzheimer Disease. The Alzheimer Disease is the main cause of dementia between aged people. In recent years it has been showing an increase in the number of patients proportional

  20. Learning when to Hold'em and When to Fold'em: ERS's Budget Hold'em Game Facilitates the Budget Development Process in Memphis

    ERIC Educational Resources Information Center

    Education Resource Strategies, 2010

    2010-01-01

    If your school district is facing a budget issue, it might surprise you to learn that the solution might very well lie in a game of cards. That certainly was the case earlier this year for the city schools of Memphis, Tennessee. The game is called Budget Hold'em, and it was developed by Education Resource Strategies (ERS) of Watertown,…

  1. Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol

    Microsoft Academic Search

    Björn Dahlöf; Richard B Devereux; Sverre E Kjeldsen; Stevo Julius; Gareth Beevers; Ulf de Faire; Frej Fyhrquist; Hans Ibsen; Krister Kristiansson; Ole Lederballe-Pedersen; Lars H Lindholm; Markku S Nieminen; Per Omvik; Suzanne Oparil; Hans Wedel

    2002-01-01

    995 Summary Background Blood pressure reduction achieved with ? -blockers and diuretics is the best recorded intervention to date for prevention of cardiovascular morbidity and death in patients with hypertension. Left ventricular hypertrophy (LVH) is a strong independent indicator of risk of cardiovascular morbidity and death. We aimed to establish whether selective blocking of angiotensin II improves LVH beyond reducing

  2. Quantitation of PET data with the EM reconstruction technique

    SciTech Connect

    Rosenqvist, G.; Dahlbom, M.; Erikson, L.; Bohm, C.; Blomqvist, G.

    1989-02-01

    The expectation maximization (EM) algorithm offers high spatial resolution and excellent noise reduction with low statistics PET data, since it incorporates the Poisson nature of the data. The main difficulties are long computation times, difficulties to find appropriate criteria to terminate the reconstruction and to quantify the resulting image data. In the present work a modified EM algorithm has been implements on a VAX 11/780. Its capability to quantify image data has been tested in phantom studies and in two clinical cases, cerebral blood flow studies and dopamine D2-receptor studies. Data from phantom studies indicate the superiority of images reconstructed with the EM technique compared to images reconstructed with the conventional filtered back-projection (FB) technique in areas with low statistics. At higher statistics the noise characteristics of the two techniques coincide. Clinical data support these findings.

  3. Analyses of Subnanometer Resolution Cryo-EM Density Maps

    PubMed Central

    Baker, Matthew L.; Baker, Mariah R.; Hryc, Corey F.; DiMaio, Frank

    2011-01-01

    Today, electron cryomicroscopy (cryo-EM) can routinely achieve subnanometer resolutions of complex macromolecular assemblies. From a density map, one can extract key structural and functional information using a variety of computational analysis tools. At subnanometer resolution, these tools make it possible to isolate individual subunits, identify secondary structures, and accurately fit atomic models. With several cryo-EM studies achieving resolutions beyond 5 Å, computational modeling and feature recognition tools have been employed to construct backbone and atomic models of the protein components directly from a density map. In this chapter, we describe several common classes of computational tools that can be used to analyze and model subnanometer resolution reconstructions from cryo-EM. A general protocol for analyzing subnanometer resolution density maps is presented along with a full description of steps used in analyzing the 4.3 Å resolution structure of Mm-cpn. PMID:20888467

  4. EMS Stretcher “Misadventures” in a Large, Urban EMS System: A Descriptive Analysis of Contributing Factors and Resultant Injuries

    PubMed Central

    Goodloe, Jeffrey M.; Crowder, Christopher J.; Arthur, Annette O.; Thomas, Stephen H.

    2012-01-01

    Purpose. There is a paucity of data regarding EMS stretcher-operation-related injuries. This study describes and analyzes characteristics associated with undesirable stretcher operations, with or without resultant injury in a large, urban EMS agency. Methods. In the study agency, all stretcher-related “misadventures” are required to be documented, regardless of whether injury results. All stretcher-related reports between July 1, 2009 and June 30, 2010 were queried in retrospective analysis, avoiding Hawthorne effect in stretcher operations. Results. During the year studied, 129,110 patients were transported. 23 stretcher incidents were reported (0.16 per 1,000 transports). No patient injury occurred. Four EMS providers sustained minor injuries. Among contributing aspects, the most common involved operations surrounding the stretcher-ambulance safety latch, 14/23 (60.9%). From a personnel injury prevention perspective, there exists a significant relationship between combative patients and crew injury related to stretcher operation, Fisher's exact test 0.048. Conclusions. In this large, urban EMS system, the incidence of injury related to stretcher operations in the one-year study period is markedly low, with few personnel injuries and no patient injuries incurred. Safety for EMS personnel and patients could be advanced by educational initiatives that highlight specific events and conditions contributing to stretcher-related adverse events. PMID:22606379

  5. Developments in the EM-CCD camera for OGRE

    NASA Astrophysics Data System (ADS)

    Tutt, James H.; McEntaffer, Randall L.; DeRoo, Casey; Schultz, Ted; Miles, Drew M.; Zhang, William; Murray, Neil J.; Holland, Andrew D.; Cash, Webster; Rogers, Thomas; O'Dell, Steve; Gaskin, Jessica; Kolodziejczak, Jeff; Evagora, Anthony M.; Holland, Karen; Colebrook, David

    2014-07-01

    The Off-plane Grating Rocket Experiment (OGRE) is a sub-orbital rocket payload designed to advance the development of several emerging technologies for use on space missions. The payload consists of a high resolution soft X-ray spectrometer based around an optic made from precision cut and ground, single crystal silicon mirrors, a module of off-plane gratings and a camera array based around Electron Multiplying CCD (EM-CCD) technology. This paper gives an overview of OGRE with emphasis on the detector array; specifically this paper will address the reasons that EM-CCDs are the detector of choice and the advantages and disadvantages that this technology offers.

  6. Low Bandwidth Vocoding using EM Sensor and Acoustic Signal Processing

    SciTech Connect

    Ng, L C; Holzrichter, J F; Larson, P E

    2001-10-25

    Low-power EM radar-like sensors have made it possible to measure properties of the human speech production system in real-time, without acoustic interference [1]. By combining these data with the corresponding acoustic signal, we've demonstrated an almost 10-fold bandwidth reduction in speech compression, compared to a standard 2.4 kbps LPC10 protocol used in the STU-III (Secure Terminal Unit, third generation) telephone. This paper describes a potential EM sensor/acoustic based vocoder implementation.

  7. Speaker verification using combined acoustic and EM sensor signal processing

    SciTech Connect

    Ng, L C; Gable, T J; Holzrichter, J F

    2000-11-10

    Low Power EM radar-like sensors have made it possible to measure properties of the human speech production system in real-time, without acoustic interference. This greatly enhances the quality and quantity of information for many speech related applications. See Holzrichter, Burnett, Ng, and Lea, J. Acoustic. SOC. Am . 103 ( 1) 622 (1998). By combining the Glottal-EM-Sensor (GEMS) with the Acoustic-signals, we've demonstrated an almost 10 fold reduction in error rates from a speaker verification system experiment under a moderate noisy environment (-10dB).

  8. Um Framework para Proviso de QoS em Redes Mveis Sem Fio1

    E-print Network

    Colcher, Sérgio

    Um Framework para Provisão de QoS em Redes Móveis Sem Fio1 Luciana dos Santos Lima, Antônio Tadeu A provisão de QoS em redes móveis sem fio integrando soluções isoladas encontradas na literatura. Esses descrita através de um cenário simulado em que serviços integrados são oferecidos sobre uma rede IP Móvel

  9. UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM ANTROPOLOGIA SOCIAL

    E-print Network

    Lucero, Jorge Carlos

    UNIVERSIDADE DE BRASÍLIA PROGRAMA DE PÓS-GRADUAÇÃO EM ANTROPOLOGIA SOCIAL PPGAS EDITAL No . 03/2011 SELEÇÃO DE CANDIDATOS ÀS VAGAS DO PROGRAMA DE PÓS-GRADUAÇÃO EM ANTROPOLOGIA SOCIAL PARA O CURSO DE-Graduação em Antropologia Social - PPGAS, no uso de suas atribuições legais, torna público e estabelece

  10. UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM ANTROPOLOGIA SOCIAL

    E-print Network

    Maier, Rudolf Richard

    UNIVERSIDADE DE BRASÍLIA PROGRAMA DE PÓS-GRADUAÇÃO EM ANTROPOLOGIA SOCIAL PPGAS EDITAL N o . M-01/2010 SELEÇÃO DE CANDIDATOS ÀS VAGAS DO PROGRAMA DE PÓS-GRADUAÇÃO EM ANTROPOLOGIA SOCIAL PARA O CURSO DE-Graduação em Antropologia Social - PPGAS, no uso de suas atribuições legais, torna público e estabelece

  11. UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM ANTROPOLOGIA SOCIAL

    E-print Network

    Maier, Rudolf Richard

    UNIVERSIDADE DE BRASÍLIA PROGRAMA DE PÓS-GRADUAÇÃO EM ANTROPOLOGIA SOCIAL PPGAS EDITAL N o . 03/2012 SELEÇÃO DE CANDIDATOS ÀS VAGAS DO PROGRAMA DE PÓS-GRADUAÇÃO EM ANTROPOLOGIA SOCIAL PARA O CURSO DE-Graduação em Antropologia Social - PPGAS, no uso de suas atribuições legais, torna público e estabelece

  12. UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM ANTROPOLOGIA SOCIAL

    E-print Network

    Maier, Rudolf Richard

    UNIVERSIDADE DE BRASÍLIA PROGRAMA DE PÓS-GRADUAÇÃO EM ANTROPOLOGIA SOCIAL EDITAL Nº. 04/2012 SELEÇÃO DE CANDIDATOS ÀS VAGAS DO PROGRAMA DE PÓS-GRADUAÇÃO EM ANTROPOLOGIA SOCIAL PARA O CURSO DE-Graduação em Antropologia Social, no uso de suas atribuições legais, torna público e estabelece as normas do

  13. Microanlise etnogrfica de interaces conversacionais: Atendimentos em Servios de Aco social

    E-print Network

    Paris-Sud XI, Université de

    Michel Gustave Joseph Binet Tese de Doutoramento em Antropologia Janeiro, 2012 tel-00815276,version1 Doutor em Antropologia, realizada sob a orientação científica do Professor Doutor Adriano Duarte Antropologia) | ISSSL-ULL Paula Godinho (Doutora em Antropologia) | FCSH-UNL Susana Trovão (Presidente do Júri

  14. UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM ANTROPOLOGIA SOCIAL

    E-print Network

    Maier, Rudolf Richard

    UNIVERSIDADE DE BRASÍLIA PROGRAMA DE PÓS-GRADUAÇÃO EM ANTROPOLOGIA SOCIAL EDITAL No 01/2014 UNIVERSIDADE DE BRASÍLIA PROGRAMA DE PÓS-GRADUAÇÃO EM ANTROPOLOGIA SOCIAL EDITAL N o 01/2014 SELEÇÃO DE CANDIDATOS COM RESIDÊNCIA PERMANENTE NO EXTERIOR ÀS VAGAS DO PROGRAMA DE PÓS-GRADUAÇÃO EM ANTROPOLOGIA SOCIAL

  15. UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM ANTROPOLOGIA SOCIAL

    E-print Network

    Lucero, Jorge Carlos

    UNIVERSIDADE DE BRASÍLIA PROGRAMA DE PÓS-GRADUAÇÃO EM ANTROPOLOGIA SOCIAL EDITAL No. 02/2011 SELEÇÃO DE CANDIDATOS ÀS VAGAS DO PROGRAMA DE PÓS-GRADUAÇÃO EM ANTROPOLOGIA SOCIAL PARA O CURSO DE-Graduação em Antropologia Social, no uso de suas atribuições legais, torna público e estabelece as normas do

  16. UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM ANTROPOLOGIA SOCIAL

    E-print Network

    Maier, Rudolf Richard

    UNIVERSIDADE DE BRASÍLIA PROGRAMA DE PÓS-GRADUAÇÃO EM ANTROPOLOGIA SOCIAL EDITAL No. 02/2010 SELEÇÃO DE CANDIDATOS ÀS VAGAS DO PROGRAMA DE PÓS-GRADUAÇÃO EM ANTROPOLOGIA SOCIAL PARA O CURSO DE-Graduação em Antropologia Social, no uso de suas atribuições legais, torna público e estabelece as normas do

  17. Imaging Gas Hydrate with Marine EM at Hydrate Ridge, Offshore Oregon

    Microsoft Academic Search

    K. A. Weitemeyer; S. Constable; J. Behrens

    2005-01-01

    We present results from a marine controlled source electromagnetic experiment (CSEM) conducted at Hydrate Ridge, Oregon in August, 2004. Transmitted EM fields were measured by a dense array of 25 seafloor EM receivers spaced at 600 m intervals, allowing for redundant sampling of the spatially varying EM fields. The data heterogeneity is represented in simple form by using pseudosection approach,

  18. Quasi-Monte Carlo Sampling to improve the Efficiency of Monte Carlo EM

    E-print Network

    Jank, Wolfgang

    Quasi-Monte Carlo Sampling to improve the Efficiency of Monte Carlo EM Wolfgang Jank Department@rhsmith.umd.edu November 17, 2003 Abstract In this paper we investigate an efficient implementation of the Monte Carlo EM al- gorithm based on Quasi-Monte Carlo sampling. The Monte Carlo EM algorithm is a stochastic version

  19. PREVALÊNCIA DE ENDOSSIMBIONTES Cardinium EM POPULAÇÕES DE ÁCAROS Brevipalpus phoenicis DE DIFERENTES REGIÕES BRASILEIRAS.

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Em B. phoenicis (Geijskes) (Acari: Tenuipalpidae), ácaro vetor de importantes fitovírus, a presença de endossimbiontes do gênero Cardinium relaciona-se ao processo de feminilização dos machos, acarretando em elevada proporção de fêmeas em populações naturais. Até o momento, não é conhecido se este e...

  20. RESOLUO No Fixa o Currculo Pleno do Curso de Tecnologia em

    E-print Network

    Paraná, Universidade Federal do

    RESOLUÇÃO No 51/11-CEPE Fixa o Currículo Pleno do Curso de Tecnologia em Orientação Comunitária do/2010-01 e por unanimidade de votos, RESOLVE: Art. 1 o - O Currículo Pleno do Curso de Tecnologia em, Artes e Linguagem e Comunicação. Art. 2 0 ­ A integralização do currículo do Curso de Tecnologia em

  1. REGIMENTO DO CURSO DE PS-GRADUAO EM CINCIA E TECNOLOGIA DE MATERIAIS E SENSORES

    E-print Network

    REGIMENTO DO CURSO DE PÓS-GRADUAÇÃO EM CIÊNCIA E TECNOLOGIA DE MATERIAIS E SENSORES TÍTULO I DOS OBJETIVOS DA ÁREA DE CONCENTRAÇÃO Art. 1 ­ A Área de Concentração em Ciência e Tecnologia de Materiais e Sensores (CMS), do Curso de Pós-graduação em Engenharia e Tecnologia Espaciais (ETE) do INPE, tem como

  2. UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM TECNOLOGIA AMBIENTAL E

    E-print Network

    Maier, Rudolf Richard

    1 UNIVERSIDADE DE BRASÍLIA PROGRAMA DE PÓS-GRADUAÇÃO EM TECNOLOGIA AMBIENTAL E RECURSOS HÍDRICOS EDITAL N°1/2014 SELEÇÃO DE CANDIDATOS ÀS VAGAS DO PROGRAMA DE PÓS-GRADUAÇÃO EM TECNOLOGIA AMBIENTAL E Coordenador do Programa de Pós-Graduação em Tecnologia Ambiental e Recursos Hídricos da Universidade de

  3. UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM TECNOLOGIA AMBIENTAL E

    E-print Network

    Maier, Rudolf Richard

    1 UNIVERSIDADE DE BRASÍLIA PROGRAMA DE PÓS-GRADUAÇÃO EM TECNOLOGIA AMBIENTAL E RECURSOS HÍDRICOS EDITAL N°2/2014 SELEÇÃO DE CANDIDATOS ÀS VAGAS DO PROGRAMA DE PÓS-GRADUAÇÃO EM TECNOLOGIA AMBIENTAL E.1 O Coordenador do Programa de Pós-Graduação em Tecnologia Ambiental e Recursos Hídricos da

  4. REGIMENTO DO CURSO DE PS-GRADUAO EM ENGENHARIA E TECNOLOGIA ESPACIAIS

    E-print Network

    REGIMENTO DO CURSO DE PÓS-GRADUAÇÃO EM ENGENHARIA E TECNOLOGIA ESPACIAIS ÁREA DE CONCENTRAÇÃO EM e Tecnologia Espaciais (ETE) objetiva formar e aperfeiçoar pessoal nos níveis de Mestrado e de Curso de Pós- graduação em Engenharia e Tecnologia Espaciais e por este Regimento de Área de

  5. REGIMENTO DO CURSO DE PS-GRADUAO EM ENGENHARIA E TECNOLOGIA ESPACIAIS

    E-print Network

    REGIMENTO DO CURSO DE PÓS-GRADUAÇÃO EM ENGENHARIA E TECNOLOGIA ESPACIAIS ÁREA DE CONCENTRAÇÃO EM e Tecnologia Espaciais (ETE) objetiva formar e aperfeiçoar pessoal nos níveis de Mestrado e de Curso de Pós-graduação em Engenharia e Tecnologia Espaciais e por este Regimento de Área de Concentração

  6. UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM TECNOLOGIA AMBIENTAL E

    E-print Network

    Lucero, Jorge Carlos

    UNIVERSIDADE DE BRASÍLIA PROGRAMA DE PÓS-GRADUAÇÃO EM TECNOLOGIA AMBIENTAL E RECURSOS HÍDRICOS EDITAL N°2/2011 SELEÇÃO DE CANDIDATOS ÀS VAGAS DO PROGRAMA DE PÓS-GRADUAÇÃO EM TECNOLOGIA AMBIENTAL E. PREÂMBULO 1.1 O Coordenador do Programa de Pós-Graduação em Tecnologia Ambiental e Recursos Hídricos da

  7. Centro de Cincias Agrrias Coordenao do Curso de Graduao em Cincia e Tecnologia de Alimentos

    E-print Network

    Floeter, Sergio Ricardo

    Centro de Ciências Agrárias Coordenação do Curso de Graduação em Ciência e Tecnologia de Alimentos-2728 Regimento Interno do Curso de Graduação em Ciência e Tecnologia de alimentos Capítulo I ­ Das disposições iniciais Art. 1º - O Curso de Graduação em Ciência e Tecnologia de Alimentos, instituído pela Resolução 005

  8. REGIMENTO DO CURSO DE PS-GRADUAO EM ENGENHARIA E TECNOLOGIA ESPACIAIS

    E-print Network

    REGIMENTO DO CURSO DE PÓS-GRADUAÇÃO EM ENGENHARIA E TECNOLOGIA ESPACIAIS ÁREA DE CONCENTRAÇÂO EM e Tecnologia Espaciais (ETE) objetiva formar e aperfeiçoar pessoal nos níveis de Mestrado e de Curso de Pós- graduação em Engenharia e Tecnologia Espaciais e por este Regimento de Área de

  9. MINISTRIO DA CINCIA, TECNOLOGIA E INOVAO (MCTI) CONCURSO PBLICO PARA PROVIMENTO DE VAGAS EM CARGOS

    E-print Network

    1 MINISTÉRIO DA CIÊNCIA, TECNOLOGIA E INOVAÇÃO (MCTI) CONCURSO PÚBLICO PARA PROVIMENTO DE VAGAS EM DA CIÊNCIA, TECNOLOGIA E INOVAÇÃO, tendo em vista o disposto na Portaria nº 553, de 8 de dezembro de, Planejamento e Infraestrutura em Ciência e Tecnologia e da Carreira de Desenvolvimento Tecnológico de que trata

  10. RESOLUO N45/11CEPE Fixa o currculo do Curso de Tecnologia em Gesto de

    E-print Network

    Paraná, Universidade Federal do

    RESOLUÇÃO Nº45/11­CEPE Fixa o currículo do Curso de Tecnologia em Gestão de Turismo, do Setor unanimidade de votos, RESOLVE: Art. 1º O Currículo do curso de Graduação em Tecnologia em Gestão de Turismo Turismo I Cultura, História e Patrimônio C.2. MUNDO DO TRABALHO Tecnologia da Informação no Turismo D

  11. UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM TECNOLOGIAS QUMICA E

    E-print Network

    Lucero, Jorge Carlos

    UNIVERSIDADE DE BRASÍLIA PROGRAMA DE PÓS-GRADUAÇÃO EM TECNOLOGIAS QUÍMICA E BIOLÓGICA EDITAL Nº 2/2012 SELEÇÃO DE CANDIDATOS AO PROGRAMA DE PÓS-GRADUAÇÃO EM TECNOLOGIAS QUÍMICA E BIOLÓGICA PARA O CURSO DE-Graduação em Tecnologias Química e Biológica, no uso de suas atribuições legais, torna público e estabelece

  12. UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM TECNOLOGIAS QUMICA E

    E-print Network

    Maier, Rudolf Richard

    UNIVERSIDADE DE BRASÍLIA PROGRAMA DE PÓS-GRADUAÇÃO EM TECNOLOGIAS QUÍMICA E BIOLÓGICA EDITAL No . 1/2012 SELEÇÃO DE CANDIDATOS ÀS VAGAS DO PROGRAMA DE PÓS- GRADUAÇÃO EM TECNOLOGIAS QUÍMICA E BIOLÓGICA PARA O Programa de Pós-Graduação em Tecnologias Química e Biológica, no uso de suas atribuições legais, torna

  13. Airborne EM for geothermal and hydrogeological mapping

    NASA Astrophysics Data System (ADS)

    Menghini, A.; Manzella, A.; Viezzoli, A.; Montanari, D.; Maggi, S.

    2012-12-01

    Within the "VIGOR" project, aimed at assessing the geothermal potential of four regions in southern Italy, Airborne EM data have been acquired, modeled and interpreted. The system deployed was SkyTEM, a time-domain helicopter electromagnetic system designed for hydrogeophysical, environmental and mineral investigations. The AEM data provide, after data acquisition, analysis, processing, and modeling, a distribution volume of electrical resistivity, spanning an investigation depth from ground surface of few hundred meters, depending on resistivity condition. Resistivity is an important physical parameter for geothermal investigation, since it proved to be very effective in mapping anomalies due to hydrothermal fluid circulation, which usually has high salt content and produces clayey alteration minerals. Since the project required, among other issues, to define geothermal resources at shallow level, it was decided to perform a test with an airborne electromagnetic geophysical survey, to verify the advantages offered by the system in covering large areas in a short time. The geophysical survey was carried out in Sicily, Italy, in late 2011, over two test sites named "Termini" and "Western Sicily". The two areas were chosen on different basis. "Termini" area is covered by extensive geological surveys, and was going to be investigated also by means of electrical tomography in its northern part. Since geological condition of Sicily, even at shallow depth, is very complex, this area provided a good place for defining the resistivity values of the main geological units outcropping in the region. "Termini" survey has been also an occasion to define relations between resistivity distribution, lithological units and thermal conductivity. The "Western Sicily" area cover the main thermal manifestations of western Sicily, and the research target was to establish whether they are characterized by common hydrogeological or tectonic features that could be mapped by resistivity. SkyTEM data have been acquired in a series of flight lines and were then processed and inverted. In the "Termini" area the flight line spacing had 150 m separation. In the "Western Sicily" area two different line spacing were used: the 1 km spacing was used for the regional mapping, whereas for infill areas, around the main hydrothermal springs, the flight lines had 100 m spacing. The total number of flight line was 4580 km, and the explored surface was in excess of 2000 km2. After acquisition, data were processed to eliminate coupling with infrastructures, and noise. Inversions was then carried out using the quasi 3-D Spatially Constrained Inversion. The obtained resistivity volume has then been the base for a detailed lithological and geothermal interpretation. Lithological and geological maps were used to constrain surface condition and to understand the resistivity ranges of the different lithological units. On the base of resistivity values, lithological units were combined to establish the main litho-resistive units, then modeled at depth, down to achievable investigation depth. This detailed interpretative modeling was also the occasion of recognizing resistivity anomalies within carbonate units, which may possibly represent hydrogeological or hydrothermal bodies. The litho-resitive 3D model is now under investigation to verify how it can represent a viable way to image thermal conductivity variations at depth.

  14. Properties of Light Waves, particles and EM spectrum

    E-print Network

    Wilkinson, Gerald S.

    Properties of Light · Waves, particles and EM spectrum · Interaction with matter · Absorption related to wavelength (f = c / ) · Shares with sound the properties of spreading loss, attenuation molecules (visual pigments) make use of changes in electron orbital states #12;Absorption by water depends

  15. The Economic Effect of Nature Farming by EM

    Microsoft Academic Search

    B. N. Lee; C. K. Kang; K. H. Lee

    Along with the increasing concern among farmers and the general public about the adverse effect of conventional farming, questions have been increasingly raised in recent years about the long-term sustainability of the current agricultural system that relies on agricultural chemicals such as fertilizers and pesticides. Effective Micro-organisms (EM), as a potentially valuable technology that pursues more ecologically oriented agriculture than

  16. EMS-generated Rhizoctonia resistance in an adapted wheat

    Technology Transfer Automated Retrieval System (TEKTRAN)

    We report the first genetic resistance in wheat to Rhizoctonia solani AG-8 and R. oryzae, the causal agents of Rhizoctonia root rot and pre-emergence damping-off. Rhizoctonia resistance was generated in the spring wheat cultivar Scarlet using EMS mutagenesis. Resistant plants, named Scarlet-Rz1, d...

  17. Under Review Scaling Down EM Using Graph Based

    E-print Network

    Davidson, Ian

    , University of California, Davis, CA, USA. Abstract. The EM algorithm is used extensively in data mining reported in KAIS as being one of the top 10 data mining algorithms. Typical applications include indoor map building, mixture models and image mining. However, as data mining applications extend to deployment beyond

  18. A experiência do dieese em pesquisa e conhecimento

    Microsoft Academic Search

    SÉRGIO E. A. MENDONÇA

    2002-01-01

    Resumo: O texto situa o nascimento do Dieese com o objetivo singular de realizar pesquisas e estudos a partir da ótica da classe trabalhadora. O Dieese nasce para tentar produzir conhecimento em bases científicas, visan- do apoiar a disputa da classe trabalhadora pela distribuição de renda nacional. Relaciona os momentos de transformação da sociedade brasileira às principais pesquisas e atividades

  19. An Innovative Tool to Assist in Rural EMS Response

    E-print Network

    Minnesota, University of

    technologies for EMS -NextGeneration 911 -IP telephony -AACN -Mobile phones -Computer Aided Dispatch (CAD) -GPS/AVL/GIS of mobile computing (smartphones) !Leverage expansion of cell phone network !Leverage the web #12;CrashHelp System Prototype #12;CrashHelp System Architecture #12;#12;Mobile Phone Application !Secure login !Add

  20. Texas Hold 'em Online Poker: A Further Examination

    ERIC Educational Resources Information Center

    Hopley, Anthony A. B.; Dempsey, Kevin; Nicki, Richard

    2012-01-01

    Playing Texas Hold 'em Online Poker (THOP) is on the rise. However, there is relatively little research examining factors that contribute to problem gambling in poker players. The aim of this study was to extend the research findings of Hopley and Nicki (2010). The negative mood states of depression, anxiety and stress were found to be linked to…

  1. Sonar-Based Mapping With Mobile Robots Using EM

    Microsoft Academic Search

    Wolfram Burgard; Dieter Fox; Hauke Jans; Christian Matenar; Sebastian Thrun

    This paper presents an algorithms for learn- ing occupancy grid maps with mobile robots equipped with range finders, such as sonar sen- sors. Our approach employs the EM algorithm to solve the concurrent mapping and localization problem. To accommodate the spatial nature of range data, it relies on a two-layered representa- tion of maps, where global maps are composed from

  2. ISSN 0103-9741 Monografias em Cincia da Computao

    E-print Network

    Barbosa, Alberto

    &P) activities, such as 3D geomodelling, seismic interpretation, real-time drilling follow-up and correction, offshore structures' design, static and dynamic simulations of these offshore structures, oil pipelines perfuração em tempo real, projeto de estruturas offshore, simulações estáticas e dinâmicas destas estruturas

  3. Inhomogeneous Media 3D EM Modeling with Integral Equation Method

    Microsoft Academic Search

    Q. di; R. Wang; Z. An; C. Fu; C. Xu

    2010-01-01

    In general, only the half space of earth is considered in electromagnetic exploration. However, for the long bipole source, because the length is close to the height of ionosphere and also most offsets between source and receivers are equal or larger than the height of ionosphere, the effect of ionosphere on the electromagnetic (EM) field should be considered when observation

  4. Symmetry-restrained flexible fitting for symmetric EM maps.

    PubMed

    Chan, Kwok-Yan; Gumbart, James; McGreevy, Ryan; Watermeyer, Jean M; Sewell, B Trevor; Schulten, Klaus

    2011-09-01

    Many large biological macromolecules have inherent structural symmetry, being composed of a few distinct subunits, repeated in a symmetric array. These complexes are often not amenable to traditional high-resolution structural determination methods, but can be imaged in functionally relevant states using cryo-electron microscopy (cryo-EM). A number of methods for fitting atomic-scale structures into cryo-EM maps have been developed, including the molecular dynamics flexible fitting (MDFF) method. However, quality and resolution of the cryo-EM map are the major determinants of a method's success. In order to incorporate knowledge of structural symmetry into the fitting procedure, we developed the symmetry-restrained MDFF method. The new method adds to the cryo-EM map-derived potential further restraints on the allowed conformations of a complex during fitting, thereby improving the quality of the resultant structure. The benefit of using symmetry-based restraints during fitting, particularly for medium to low-resolution data, is demonstrated for three different systems. PMID:21893283

  5. Skin detection using the EM algorithm with spatial constraints

    E-print Network

    Gevers, Theo

    Skin detection using the EM algorithm with spatial constraints A. Diplaros T. Gevers N. Vlassis,gevers,vlassis}@science.uva.nl Abstract ­ In this paper, we propose a color-based method for skin detection and segmentation, which also takes into account the spatial coherence of the skin pixels. We treat the problem of skin detection

  6. Using EM for Reinforcement Learning Peter Dayan Geoffrey E Hinton

    E-print Network

    Hinton, Geoffrey E.

    return, even though it can make large changes in the values of the parameters. The proof is based) algorithm (Baum, Petrie, Soules & Weiss, 1970; Dempster, Laird & Rubin, 1977) and, as with EM, there can proof demonstrates that the RPP is well-founded. 2 Theory The RPP operates to improve the parameters Ã?

  7. Germinação de Sementes de Forrageiras em Diferentes Profundidades de Semeadura

    Microsoft Academic Search

    Adauton Vilela de Rezende; Hélio Henrique Vilela; Geraldo Benedito de Souza Almeida; Paulo Roberto; Correa Landgraf; Gustavo Augusto Andrade; Paulo de Figueiredo Vieira

    3 Aluno de graduação em Agronomia - UNIFENAS Abstract: The experiment was conducted at José do Rosário Vellano University - UNIFENAS, in Alfenas, MG, with the purpose of evaluating the germination of forage seeds at different sowing depths. The experimental design was in randomized blocks with three replicates, four forages plants and four sowing depths being utilized, amounting to 20

  8. Hierarchical Mixtures of Experts and the EM Algorithm

    Microsoft Academic Search

    Michael I. Jordan; Robert A. Jacobs

    1994-01-01

    We present a tree-structured architecture for supervised learning. The statistical model underlying the architecture is a hierarchical mixture model in which both the mixture coefficients and the mixture components are generalized linear models (GLIM's). Learning is treated as a maximum likelihood problem; in particular, we present an Expectation-Maximization (EM) algorithm for adjusting the parameters of the architecture. We also develop

  9. ISSN 0103-9741 Monografias em Cincia da Computao

    E-print Network

    Endler, Markus

    DE JANEIRO RUA MARQUÊS DE SÃO VICENTE, 225 - CEP 22451-900 RIO DE JANEIRO - BRASIL #12;Monograas em, Computer Science Department, LES - Rio de Janeiro - Brazil 2 Federal University of Rio Grande do Norte Marquês de São Vicente, 225 - Gávea 22451-900 Rio de Janeiro RJ Brasil Tel. +55 21 3527-1516 Fax: +55 21

  10. ISSN 0103-9741 Monografia em Cincia da Computao

    E-print Network

    Endler, Markus

    Departamento de Informática PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO RUA MARQUÊS DE SÃO VICENTE, 225 - CEP 22451-900 RIO DE JANEIRO #12;Monografias em Ciência da Computação, No. 10/10 ISSN: 0103 of Informatics ­ PUC-Rio ­ Rio de Janeiro, RJ ­ Brazil {hpiccinini, melissa, casanova, furtado}@inf.puc-rio.br 2

  11. ISSN 0103-9741 Monografias em Cincia da Computao

    E-print Network

    Endler, Markus

    Pereira de Lucena Departamento de Informática PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO RUA MARQUÊS DE SÃO VICENTE, 225 - CEP 22451-900 RIO DE JANEIRO - BRASIL #12;Monografias em Ciência da Departamento de Informática Pontifícia Universidade Católica do Rio de Janeiro (PUC-Rio), Rio de Janeiro

  12. ISSN 0103-9741 Monografias em Cincia da Computao

    E-print Network

    Endler, Markus

    José Pereira de Lucena Departamento de Informática PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO RUA MARQUÊS DE SÃO VICENTE, 225 - CEP 22453-900 RIO DE JANEIRO - BRASIL #12;Monografias em Ciência da Departamento de Informática Pontifícia Universidade Católica do Rio de Janeiro (PUC-Rio), Rio de Janeiro

  13. ISSN 0103-9741 Monografias em Cincia da Computao

    E-print Network

    Endler, Markus

    Departamento de Informática PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO RUA MARQUÊS DE SÃO VICENTE, 225 - CEP 22451-900 RIO DE JANEIRO - BRASIL #12;Monografias em Ciência da Computação, No. 16/09 ISSN: 0103 Rio de Janeiro (PUC-Rio), Rio de Janeiro, Brasil {mgatti, lucena, afgarcia}@inf.puc-rio.br Abstract

  14. ISSN 0103-9741 Monografias em Cincia da Computao

    E-print Network

    Endler, Markus

    PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO RUA MARQUÊS DE SÃO VICENTE, 225 - CEP 22453-900 RIO DE JANEIRO - BRASIL #12;PUC RIO - DEPARTAMENTO DE INFORMÁTICA ISSN 0103-9741 Monografias em Ciência da Departamento de Informática Pontifícia Universidade Católica do Rio de Janeiro ­ PUC-Rio Rua Marquês de São

  15. ISSN 0103-9741 Monografias em Cincia da Computao

    E-print Network

    Endler, Markus

    Informática PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO RUA MARQUÊS DE SÃO VICENTE, 225 - CEP 22453-900 RIO DE JANEIRO - BRASIL #12;PUC RIO - DEPARTAMENTO DE INFORMÁTICA ISSN 0103-9741 Monografias em-900 Rio de Janeiro RJ Brazil Tel. +55 21 3114-1516 Fax: +55 21 3114-1530 E-mail: bib-di@inf.puc-rio.br #12

  16. ISSN 0103-9741 Monografias em Cincia da Computao

    E-print Network

    Endler, Markus

    Lucena Departamento de Informática PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO RUA MARQUÊS DE SÃO VICENTE, 225 - CEP 22451-900 RIO DE JANEIRO - BRASIL #12;Monografias em Ciência da Computação, No. 03 Pereira de Lucena 2 1 PUC-Rio, Rio de Janeiro ­ Brazil 2 PUC-Rio, Computer Science Department, LES - Rio

  17. ISSN 0103-9741 Monografias em Cincia da Computao

    E-print Network

    Endler, Markus

    JANEIRO RUA MARQUÊS DE SÃO VICENTE, 225 - CEP 22451-900 RIO DE JANEIRO - BRASIL #12;Monograas em Ciência Informática, LES - Rio de Janeiro - Brasil {ionunes,cnunes,lucena}@inf.puc-rio.br, guga@les.inf.puc-rio Marquês de São Vicente, 225 - Gávea 22451-900 Rio de Janeiro RJ Brasil Tel. +55 21 3527-1516 Fax: +55 21

  18. ISSN 0103-9741 Monografias em Cincia da Computao

    E-print Network

    Endler, Markus

    PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO RUA MARQUÊS DE SÃO VICENTE, 225 - CEP 22453-900 RIO DE JANEIRO - BRASIL #12;PUC RIO - DEPARTAMENTO DE INFORMÁTICA ISSN 0103-9741 Monografias em Ciência da Rio de Janeiro ­ PUC-Rio Rua Marquês de São Vicente, 225, 22453-900. Rio de Janeiro, Brasil. [lucena,hugo]@inf.puc-rio

  19. ISSN 0103-9741 Monografias em Cincia da Computao

    E-print Network

    Endler, Markus

    Informática PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO RUA MARQUÊS DE SÃO VICENTE, 225 - CEP 22453-900 RIO DE JANEIRO - BRASIL #12;PUC RIO - DEPARTAMENTO DE INFORMÁTICA ISSN 0103-9741 Monografias em PUC-Rio Departamento de Informática Rua Marquês de São Vicente, 225 - Gávea 22453-900 Rio de Janeiro

  20. ISSN 0103-9741 Monografias em Cincia da Computao

    E-print Network

    Endler, Markus

    Departamento de Informática PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO RUA MARQUÊS DE SÃO VICENTE, 225 - CEP 22451-900 RIO DE JANEIRO - BRASIL #12;Monografias em Ciência da Computação, No. 53/08 ISSN: 0103, Rio de Janeiro ­ RJ ­ Brasil {milene, mauserr}@les.inf.puc-rio.br {lucena}@inf.puc-rio.br Abstract

  1. ISSN 0103-9741 Monografias em Cincia da Computao

    E-print Network

    Endler, Markus

    JANEIRO RUA MARQUÊS DE SÃO VICENTE, 225 - CEP 22453-900 RIO DE JANEIRO - BRASIL #12;Monografias em Ciência Departamento de Informática ­ PUC-Rio Rua Marquês de São Vicente, 225, Rio de Janeiro ­ Brasil, 22453-900 {guga, Rio de Janeiro, Brasil, 22290-270 choren@de9.ime.br Abstract. In open multi-agent systems, in which

  2. Online EM Algorithm for Hidden Markov Models Olivier Cappe

    E-print Network

    Paris-Sud XI, Université de

    Online EM Algorithm for Hidden Markov Models Olivier Capp´e LTCI, Telecom ParisTech & CNRS Abstract likelihood estimator for large sample sizes. Keywords Hidden Markov Models, Expectation Hidden Markov modelling is a key concept of statistical time series analysis, which has had a wide

  3. Online EM Algorithm for Hidden Markov Models Olivier Cappe

    E-print Network

    Online EM Algorithm for Hidden Markov Models Olivier Capp´e LTCI, TELECOM ParisTech & CNRS Abstract This paper is about the estimation of fixed model parameters in hidden Markov models us- ing an online (or evaluated through simulations in the case of a noisily observed Markov chain. Keywords Hidden Markov Models

  4. A Generalized Partial Credit Model: Application of an EM Algorithm

    Microsoft Academic Search

    Eiji Muraki

    1992-01-01

    The partial credit model (PCM) with a varying slope parameter is developed and called the generalized partial credit model (GPCM). The item step parameter of this model is decomposed to a location and a threshold parameter, following Andrich's (1978) rating scale formulation. The EM algorithm for estimating the model parameters is derived. The performance of this generalized model is compared

  5. Cost-Effectiveness Analysis of Helicopter EMS for Trauma Patients

    Microsoft Academic Search

    Peter A Gearhart; Richard Wuerz; A. Russell Localio

    1997-01-01

    Study objective: To evaluate the cost-effectiveness of helicopter EMS for trauma patients. Methods: We applied a cost-effectiveness analysis from the service provider's perspective to cost and effectiveness estimates. The cost estimates comprise direct operating costs and additional survivors' hospital costs. The effectiveness estimates were calculated with the TRISS methodology from literature sources and data from a cohort of patients transported

  6. Nonlinear Cyclotron-Resonance Accelerations by a Generalized EM Wave

    E-print Network

    Boyer, Edmond

    Nonlinear Cyclotron-Resonance Accelerations by a Generalized EM Wave AKIMOTO, Kazuhiro and HOJO that the well-known cyclotron resonance may be classified into three regimes as the length and/or the amplitude of the pulse are varied. Namely, as the pulse amplitude increases, the transit-time cyclotron

  7. Communications technology guidelines for EMS\\/SCADA systems

    Microsoft Academic Search

    Donald J. Marihart

    2001-01-01

    The purpose of this Guideline Technical Paper is to provide a summary of the different communications technologies available for use or application with EMS\\/SCADA system projects. All of the various communication media are addressed with a brief description along with tables of the advantages and disadvantages of each and recommendations for choosing the most appropriate communication technology. The technologies discussed

  8. TESE DE DOUTORADO EM ENGENHARIA DE SISTEMAS ELETRNICOS E AUTOMAO

    E-print Network

    de Queiroz, Ricardo L.

    BRASÍLIA FACULDADE DE TECNOLOGIA #12;#12;UNIVERSIDADE DE BRASÍLIA FACULDADE DE TECNOLOGIA DEPARTAMENTO DE Tecnologia TESE DE DOUTORADO EM ENGENHARIA DE SISTEMAS ELETRÔNICOS E AUTOMAÇÃO REALCE DE VÍDEO PARA de Engenharia Elétrica da Faculdade de Tecnologia da Universidade de Brasília, como parte dos

  9. Tecnologia Adaptativa Aplicada à Otimização de Código em Compiladores

    Microsoft Academic Search

    Júlio C. Luz; João J. Neto

    The programming memory space of embedded microcontrolled systems is usually limited. Although, compilers nowadays apply optimizing transformations to the embedded software, the lack of memory space can become a critical probl em to the designer with the introduction of new features and corrections in the original softwa re. In contrast, workstations hosting development systems for embedded applications are faster and

  10. DISSERTAO DE MESTRADO EM ENGENHARIA REDUO DE COMPLEXIDADE

    E-print Network

    de Queiroz, Ricardo L.

    TECNOLOGIA #12;#12;UNIVERSIDADE DE BRASÍLIA Faculdade de Tecnologia DISSERTAÇÃO DE MESTRADO EM ENGENHARIA Dissertação de mestrado submetida ao Departamento de Engenharia Elétrica da Faculdade de Tecnologia da Processamento de Sinais, 2008). Dissertação de Mestrado. Universidade de Brasília. Faculdade de Tecnologia

  11. Life at Low Reynolds Number E.M. Purcell

    E-print Network

    Millis, Andrew

    Life at Low Reynolds Number E.M. Purcell Lyman Laboratory, Harvard University, Cambridge, Mass elementary physics even if we don't throw much light on the other subjects. Now this is that kind know Viki's program of explaining everything including the height of mountains, with the elementary

  12. População estelar nuclear e extranuclear em galáxias Seyfert 2

    NASA Astrophysics Data System (ADS)

    Raimann, D. I.; Storchi-Bergmann, T.; Cid Fernandes, R., Jr.; Delgado, R. M. G.; Schmitt, H.; Heckman, T.; Leitherer, C.

    2003-08-01

    A luz das estrelas foi, historicamente, vista por observadores de AGNs como uma poluição inconveniente. Conseqüentemente, a informação contida nas características estelares foi, durante muito tempo, largamente omitida. Nos primeiros estudos, o método empregado para remover esta contaminação estelar foi representá-la por um template de galáxia elíptica e subtraí-la do espectro observado, restando o puro AGN como um resíduo. Hoje sabemos que não é tão simples representar essa população. Vários estudos têm mostrado a presença de formação estelar recente próxima a região nuclear de galáxias Seyfert. Neste trabalho foi revisada a abordagem tradicional, tendo-se focalizado a análise na luz estelar. Espectros óticos de fenda longa, com alta razão sinal/ruído, foram usados para estudar a variação radial das larguras equivalentes de linhas de absorção e cores do contínuo. Utilizando o método de síntese espectral de populações estelares, foram estimadas as contribuições de populações estelares de diferentes idades (e de um contínuo tipo lei de potência) para a luz integrada das galáxias, em 4020A. As principais conclusões deste trabalho são: na região nuclear, mais da metade das galáxias Seyfert 2 da amostra (57%) apresenta contribuições das populações com 100 milhões de anos ou mais jovens superior a 20% do fluxo em 4020A, enquanto que em cerca de 40% delas a componente de 3 milhões de anos (e/ou luz que provem de um núcleo ativo) tem contribuição significativa (maior do que 10%). Estas contribuições em geral decrescem quando se vai para regiões mais distantes do centro das galáxias, respectivamente 53% e 30% a 1kpc, 40% e 15% a 3kpc do centro das galáxias. Estes resultados foram comparados com aqueles obtidos para uma amostra de galáxias não ativas de mesmo tipo de Hubble das Seyfert. Em uma análise inicial nota-se que em geral as galáxias Seyfert apresentam contribuições das populações de 100 milhões de anos maiores do que aquelas encontradas nas galáxias não ativas, sugerindo uma ligação entre a formação estelar e a atividade em galáxias.

  13. GPS computer navigators to shorten EMS response and transport times.

    PubMed

    Ota, F S; Muramatsu, R S; Yoshida, B H; Yamamoto, L G

    2001-05-01

    GPS (global positioning satellite system to determine one's position on earth) units have become inexpensive and compact. The purpose of this study is to assess the effectiveness of a GPS enhanced computer street map navigator to improve the ability of EMS drivers in an urban setting to locate their destination and shorten response times. For part I, residential addresses in the city were randomly selected from a telephone directory. Two driver/navigator teams were assigned to drive to the address adhering to speed limits. One team used a standard street map, whereas the other team used a GPS computer navigator. The travel time and distance of the runs were compared. For part II, the computer GPS navigator was placed on an ambulance to supplement their normal methods of navigation to find the address requesting EMS. After the run was completed, EMS providers were interviewed to determine their opinion of whether the GPS navigator was helpful. For part I the results showed that in the 29 initial test runs, comparing the GPS team versus the standard map team, the mean distances traveled were 8.7 versus 9.0 kilometers (not significant) and the mean travel times were 13.5 versus 14.6 minutes (P=.02), respectively. The GPS team arrived faster in 72% runs. For part II the results showed that most EMS providers surveyed noted that the GPS computer navigator enhanced their ability to find the destination and all EMS providers acknowledged that it would enhance their ability to find a destination in an area in which they were unfamiliar. These results suggest that a portable GPS computer navigator system is helpful and can enhance the ability of prehospital care providers to locate their destination. Because these units are accurate and inexpensive, GPS computer navigators may be a valuable tool in reducing pre-hospital transport times. PMID:11326345

  14. Effective Teaching of Photonics E&M Theory Using COMSOL

    NSDL National Science Digital Library

    Photonics and optical communications, after the exuberant growth and subsequent down turn in late 1990s and early 2000s, have entered a more mature and stable growth phase. As the technology of choice for long distance, high data rate, and high performance communication systems underlying the now ubiquitous Internet communications, photonics and optical communication professionals are and will continue to be in high demand. Because electromagnetic (E&M) theory is the foundation of photonics and optical communications, mastery of E&M theory is essential for those electrical engineering (EE) students who want to develop a career in this field. Traditionally, rigorous analytic skills in advanced mathematics especially in subjects such as partial differential equations (PDE) and linear algebra are a must to the understanding and applications of E&M theory, as well as photonic device and waveguide designs. However, as practical designs grow in complexity, even the most sophisticated and advanced analytic techniques in these mathematical subject areas can quickly fall short of being a suitable practical design tool. Standard industry practices utilize comprehensive software simulation packages to address these design needs. It is therefore appropriate and advantageous for EE students to learn and more importantly visualize the E&M theory by combining the basic mathematical principles, e.g., the Maxwell equations and wave equations, with practical software tools that they are more likely to use in their professional life. This paper discusses the introduction of COMSOL, a predominant industry PDE solver, to senior EE undergraduates as a learning tool of fundamental concepts in photonics such as transverse electrical (TE) modes and transverse magnetic (TM) modes in planar waveguide designs. This teaching method improves teaching effectiveness of E&M field and wave theory by helping the students better understand mathematical complexities through this readily available and reliable software tool. In addition to the theory, the students also gain the design capability using these industry standard software packages, and therefore bridging the gap between theory and practice.

  15. Signals Attenuation and Application of EM-MWD in China

    NASA Astrophysics Data System (ADS)

    Wang, R.; Liu, H.; Yang, Q.; Li, J.; Wu, D.

    2012-12-01

    In the course of drilling utilizes directional well and horizontal well, it is indispensable to master timely and exact geological guide information, and offering services for such complicated drilling is electromagnetic Measurement While Drilling (EM-MWD) which can measure guide data of drilling tool in the hole and formation data while drilling. This knowledge allows the directional driller to make appropriate mechanical corrections in drill string orientation that will allow the advancing drill bit to hit an intended subsurface target area. Based on electromagnetic field theory, the paper has studied the propagation particularity and attenuation regularity that the signals of electromagnetic wave for EM-MWD transmit in stratum. The paper also gives a brief introduction of the containing, the work principle and the main technology parameter of EM-MWD. To check up the performance of EM-MWD, the field test of 5 wells were carried out in Shengli Oilfield and Liaohe Oilfield. Numerical simulation results indicate the signal attenuation will be added with the decrease of the stratum resistibility. In the frequency range from 1 to 10 Hz the stratum absorptivity is tiny and does not add noticeably with the increase of the electromagnetic wave frequency and the decrease of the stratum resistibility. In the frequency range from 1 to 10000 Hz the stratum absorptivity does not increase noticeably with the decrease of the dielectric constant of the stratum. Field test demonstrate that EM-MWD receives successfully signal emitted from depth underground 1600 meters in Shengli oilfield and 2400 meters in Liaohe oilfield. Our results indicate that numerical simulation methods are comparable to field test.

  16. ATTRACT-EM: A New Method for the Computational Assembly of Large Molecular Machines Using Cryo-EM Maps

    PubMed Central

    de Vries, Sjoerd J.; Zacharias, Martin

    2012-01-01

    Many of the most important functions in the cell are carried out by proteins organized in large molecular machines. Cryo-electron microscopy (cryo-EM) is increasingly being used to obtain low resolution density maps of these large assemblies. A new method, ATTRACT-EM, for the computational assembly of molecular assemblies from their components has been developed. Based on concepts from the protein-protein docking field, it utilizes cryo-EM density maps to assemble molecular subunits at near atomic detail, starting from millions of initial subunit configurations. The search efficiency was further enhanced by recombining partial solutions, the inclusion of symmetry information, and refinement using a molecular force field. The approach was tested on the GroES-GroEL system, using an experimental cryo-EM map at 23.5 Å resolution, and on several smaller complexes. Inclusion of experimental information on the symmetry of the systems and the application of a new gradient vector matching algorithm allowed the efficient identification of docked assemblies in close agreement with experiment. Application to the GroES-GroEL complex resulted in a top ranked model with a deviation of 4.6 Å (and a 2.8 Å model within the top 10) from the GroES-GroEL crystal structure, a significant improvement over existing methods. PMID:23251350

  17. XXIII Congresso Brasileiro em Engenharia Biomdica XXIII CBEB IDENTIFICAO DA DOENA DE CHAGAS BASEADA EM ANLISE DE

    E-print Network

    Carvalho, João Luiz

    XXIII Congresso Brasileiro em Engenharia Biomédica ­ XXIII CBEB 1 IDENTIFICA��O DA DOEN�A DE CHAGAS-DF, Brasil joaoluiz@pgea.unb.br Abstract: Chagas' disease severely affects autonomic function, specially through the analysis of heart rate variability (HRV). This work aims at identifying Chagas' disease

  18. O CONTEXTO ESCOLAR EM CRIANÇAS COM SÍNDROME NEFRÓTICO E COM DOENÇA CELÍACA: PERCEPÇÕES DOS PROFESSORES EM ÁREAS ESPECÍFICAS

    Microsoft Academic Search

    Salomé Vieira Santos

    RESUMO: No âmbito de um estudo mais vasto dirigido para o impacto do Síndrome Nefrótico e da Doença Celíaca na infância, pretende-se avaliar as percepções dos professores face às crianças em áreas específicas do contexto escolar. Para tal utilizam-se dois questionários: o primeiro, construído para o efeito, contempla conteúdos como a adaptação da criança à escola, a reacção dos professores

  19. Approved Module Information for EM4005, 2014/5 Module Title/Name: Management of Change Module Code: EM4005

    E-print Network

    Neirotti, Juan Pablo

    Approved Module Information for EM4005, 2014/5 Module Title/Name: Management of Change Module Code: To understand the theory of change and how we can manage it successfully in today?s engineering business environment. To explain the basic ideas behind change management and explore how they impact organizations

  20. Approved Module Information for EM4003, 2014/5 Module Title/Name: Project Management Module Code: EM4003

    E-print Network

    Neirotti, Juan Pablo

    Approved Module Information for EM4003, 2014/5 Module Title/Name: Project Management Module Code Credits: 10 Module Management Information Module Leader Name Robin Clark Email Address r Information Module Aims: To explore the theory of project management and its application to real life

  1. Algoritmos e Estruturas de Dados II IBm1022 Departamento de Computao e Matemtica 2 Semestre/2012

    E-print Network

    Baranauskas, José Augusto

    paciente contendo os campos: paciente-id, nome, sexo, idade. A chave é campo paciente-id, um inteiro. O arquivo paciente deve ser criado contendo os seguintes registros: Registro paciente-id nome sexo idade 1 1 Sexo Idade 3 3 Alfredo Piva m 25 Posicionar em qual registro? 5 Posicionando... Ponteiro no registro

  2. Composting of rice straw with effective microorganisms (EM) and its influence on compost quality

    PubMed Central

    2013-01-01

    This study aims to assess the effect of EM application on the composting process of rice straw with goat manure and green waste and to evaluate the quality of both compost treatments. There are two treatment piles in this study, in which one pile was applied with EM and another pile without EM. Each treatment was replicated three times with 90 days of composting duration. The parameters for the temperature, pH, TOC and C/N ratio, show that decomposition of organic matter occurs during the 90-day period. The t-test conducted shows that there is a significant difference between compost with EM and compost without EM. The application of EM in compost increases the macro and micronutrient content. The following parameters support this conclusion: compost applied with EM has more N, P and K content (P?EM. Although the Fe in compost with EM is much higher (P?EM, for Zn and Cu, there is no significant difference between treatments. This study suggests that the application of EM is suitable to increase the mineralization in the composting process. The final resultant compost indicated that it was in the range of the matured level and can be used without any restriction. PMID:23390930

  3. Application of Electromagnetic (EM) Separation Technology to Metal Refining Processes: A Review

    NASA Astrophysics Data System (ADS)

    Zhang, Lifeng; Wang, Shengqian; Dong, Anping; Gao, Jianwei; Damoah, Lucas Nana Wiredu

    2014-12-01

    Application of electromagnetic (EM) force to metal processing has been considered as an emerging technology for the production of clean metals and other advanced materials. In the current paper, the principle of EM separation was introduced and several schemes of imposing EM field, such as DC electric field with a crossed steady magnetic field, AC electric field, AC magnetic field, and traveling magnetic field were reviewed. The force around a single particle or multi-particles and their trajectories in the conductive liquid under EM field were discussed. Applications of EM technique to the purification of different liquid metals such as aluminum, zinc, magnesium, silicon, copper, and steel were summarized. Effects of EM processing parameters, such as the frequency of imposed field, imposed magnetic flux density, processing time, particle size, and the EM unit size on the EM purification efficiency were discussed. Experimental and theoretical investigations have showed that the separation efficiency of inclusions from the molten aluminum using EM purification could as high as over 90 pct. Meanwhile, the EM purification was also applied to separate intermetallic compounds from metal melt, such as ?-AlFeMnSi-phase from the molten aluminum. And then the potential industrial application of EM technique was proposed.

  4. Development of the Emergency Medical Services Role Identity Scale (EMS-RIS).

    PubMed

    Donnelly, Elizabeth A; Siebert, Darcy; Siebert, Carl

    2015-03-01

    This article describes the development and validation of the theoretically grounded Emergency Medical Services Role Identity Scale (EMS-RIS), which measures four domains of EMS role identity. The EMS-RIS was developed using a mixed methods approach. Key informants informed item development and the scale was validated using a representative probability sample of EMS personnel. Factor analyses revealed a conceptually consistent, four-factor solution with sound psychometric properties as well as evidence of convergent and discriminant validities. Social workers work with EMS professionals in crisis settings and as their counselors when they are distressed. The EMS-RIS provides useful information for the assessment of and intervention with distressed EMS professionals, as well as how role identity may influence occupational stress. PMID:25760489

  5. Avaliação do índice de temperatura de globo negro e umidade e desempenho de suínos nas fases de crescimento e terminação criados em sistemas em camas sobrepostas em condições de verão

    Microsoft Academic Search

    Ilda de Fátima Ferreira Tinôco; Cecília de Fátima Souza; Paulo Armando Victoria de Oliveira; Robson Mendes de Paulo; Josiane Aparecida Campos; Cinara da Cunha Siqueira Carvalho; Marcelo Bastos Cordeiro

    2007-01-01

    RESUMO - Um estudo foi realizado com o objetivo de avaliar o sistema de criação em camas sobrepostas de maravalha e de casca de arroz, em comparação ao piso tradicional de concreto e sua influência no desempenho dos animais com base no ITGU (Índice de Temperatura de Globo negro e Umidade), no ganho de peso, no consumo de ração, na

  6. Em polypeptide and its messenger RNA levels are modulated by abscisic acid during embryogenesis in wheat.

    PubMed

    Williamson, J D; Quatrano, R S; Cuming, A C

    1985-10-15

    The effect of abscisic acid (ABA) on the expression of the 'early-methionine-labeled' (Em) polypeptide was examined in cultured, immature wheat (Triticum aestivum, L.) embryos and in developing embryos in planta. A complementary DNA (cDNA) library was constructed from poly(A)-rich RNA from immature embryos cultured in the presence of ABA. ABA-enhanced sequences were first identified by differential colony-blot hybridization, and then verified using RNA slot-blot analysis. Dot-blot hybridization showed that one clone, p1015, was homologous to the previously isolated Em cDNA, pWG432. Electrophoretic analysis of the hybrid-select translation product of p1015 confirmed its identity as an Em sequence. Comparison of the p1015 cDNA insert size and the Em message size, from northern blot analysis, showed that p1015 contained about 87% of the Em sequence. RNA slot-blot analysis and protein electrophoresis showed that Em message, but not Em protein, accumulated at a low, basal level in immature embryos in the absence of ABA. Neither Em message nor Em protein was seen in three-day germinated seedlings. Steady-state levels of Em message and protein increased in immature embryos in the presence of ABA, both in culture and in planta. Regulation appeared to be primarily at the level of transcription or specific message stability. Regulation may also involve specific protein stability, since synthesis of Em protein continued in immature embryos in the absence of ABA, but Em protein did not accumulate in detectable amounts. We conclude that ABA specifically modulates Em message and protein levels in immature embryos, but is probably not responsible for the embryogenic specificity of Em expression. PMID:2932332

  7. População nuclear e extranuclear em rádio-galáxias

    NASA Astrophysics Data System (ADS)

    Raimann, D. I.; Storchi-Bergmann, T.; Quintana, H.; Alloin, D.; Hunstead, R.; Wisotzki, L.

    2003-08-01

    A natureza do contínuo UV/ótico em rádio-galáxias é muito importante para o seu entendimento. Em baixos redshifts existem evidências de que muitas delas são dominadas no ótico por luz de estrelas velhas, características de galáxias early-type e em altos redshifts a característica dominante é um excesso de luz no UV, freqüentemente associado com estruturas que estão alinhadas aos eixos das estruturas rádio em grande escala. Inicialmente esse excesso foi interpretado como devido a episódios intensos de formação estelar nas galáxias hospedeiras. Entretanto, as descobertas dos alinhamentos entre as estruturas UV e rádio modificaram essa idéia. Foi proposto que a formação estelar é iniciada pela passagem do jato rádio através do meio interestelar das galáxias hospedeiras. A natureza do excesso UV começou a ser compreendida em um estudo detalhado do continuo ótico da 3C321, onde se concluiu que o contínuo desta galáxia tem origem multicomponente, com contribuições de populações velhas e intermediárias, de luz espalhada oriunda de um quasar obscurecido e do contínuo nebular. No presente trabalho estudamos a população nuclear e extranuclear de uma amostra de 24 rádio-galáxias, utilizando espectros óticos de fenda longa, com alta razão sinal/ruído. Através do método de síntese espectral de populações estelares, foram estimadas as contribuições de populações estelares de diferentes idades (e de um contínuo tipo lei de potência devido a um AGN, FC) para a luz integrada das galáxias, em 4020Å. As principais conclusões deste trabalho são: apenas quatro dos objetos estudados têm contribuições significativas (maiores do que 10%) das populações de 100 milhões de anos ou mais jovens (ou de FC) ao longo da região espacial estudada (6 kpc centrais); nenhuma das rádio-galáxias de tipo FRI estudadas tem contribuição significativa destas populações ao longo desta região; duas (de oito) de tipo FRII tem contribuições significativas da luz que vem do AGN, na região nuclear; uma tem contribuição significativa das populações de 100 milhões de anos e mais jovens ao longo dos 4 kpc centrais, indicando claramente a presença de formação estelar recente. Comparando estes resultados com aqueles obtidos para uma amostra de galáxias não ativas de mesmo tipo de Hubble das rádio, encontramos que a principal diferença entre as duas amostras está na contribuição da população de 1 bilhão de anos, geralmente maior nas rádio-galáxias.

  8. Environmental Restoration and Waste Management (EM) program: An introduction

    SciTech Connect

    Not Available

    1990-12-01

    This booklet introduces the reader to the mission and functions of a major new unit within the US Department of Energy (DOE): the Office of Environmental Restoration and Waste Management (EM). The Secretary of Energy established EM in November 1989, implementing a central purpose of DOE's first annual Environmental Restoration and Waste Management Five-Year Plan, which had appeared three months earlier. The contents of this booklet, and their arrangement, reflect the annual update of the Five-Year Plan. The Five-Year Plan supports DOE's strategy for meeting its 30-year compliance and cleanup goal. This strategy involves: focusing DOE's activities on eliminating or reducing known or recognized potential risks to worker and public health and the environment, containing or isolating, removing, or detoxifying onsite and offsite contamination, and developing technology to achieve DOE's environmental goals.

  9. Superconducting Electromagnetic Suspension (EMS) system for Grumman Maglev concept

    NASA Technical Reports Server (NTRS)

    Kalsi, Swarn S.

    1994-01-01

    The Grumman developed Electromagnetic Suspension (EMS) Maglev system has the following key characteristics: a large operating airgap--40 mm; levitation at all speeds; both high speed and low speed applications; no deleterious effects on SC coils at low vehicle speeds; low magnetic field at the SC coil--less than 0.35 T; no need to use non-magnetic/non-metallic rebar in the guideway structure; low magnetic field in passenger cabin--approximately 1 G; low forces on the SC coil; employs state-of-the-art NbTi wire; no need for an active magnet quench protection system; and lower weight than a magnet system with copper coils. The EMS Maglev described in this paper does not require development of any new technologies. The system could be built with the existing SC magnet technology.

  10. COMUNICAÇÃO DESEMPENHO DE CULTIVARES PARA A PRODUÇÃO DE MILHO VERDE EM DIFERENTES ÉPOCAS E DENSIDADES DE SEMEADURA EM LAVRAS-MG

    Microsoft Academic Search

    CARNEIRO DE PAIVA JUNIOR; RENZO GARCIA VON PINHO; ÉDILA VILELA DE RESENDE VON PINHO; SÉRGIO GERALDO DE RESENDE

    RES UMO - Com o objetivo de avaliar a viabilidade técnica para a produção de milho verde no município de Lavras- MG, foram avaliadas treze cultivares de milho em três épocas (duas no verão e uma na safrinha) e em duas densidades (35 mil e 55 mil plantas\\/ha) de semeadura. Foram avaliadas as característic as de peso de espigas empalhadas,

  11. Submetido em 5 de janeiro de 2010. Aceito em 12 de junho de 2010. Universidade Federal do Rio de Janeiro, Departamento de Gentica, Laboratrio de Biodiversidade Molecular. Cidade

    E-print Network

    Solé-Cava, Antonio M.

    1 Submetido em 5 de janeiro de 2010. Aceito em 12 de junho de 2010. 2 Universidade Federal do Rio, 21941-590 Rio de Janeiro RJ, BRAZIL. 3 Bolsista de Doutorado CNPq. E-mail: almeida.d@gmail.com 4/UFRJ, Departamento de Invertebrados. Quinta da Boa Vista, São Cristovão, 20940-040, Rio de Janeiro RJ, BRAZIL

  12. Influência da cobertura e do solo na composição florística do sub-bosque em uma floresta estacional semidecidual em Viçosa, MG, Brasil1

    Microsoft Academic Search

    João Augusto; Alves Meira-Neto; Fernando Roberto Martins; Agostinho Lopes de Souza

    RESUMO - (Influência da cobertura e do solo na composição florística do sub-bosque em uma floresta estacional semidecidual em Viçosa, MG, Brasil). A relação ecológica planta-luz tem sido estudada desde o início do século XX. As análises da relação da luminosidade ao nível das comunidades florestais têm se valido de medições indiretas por meio de índices de cobertura, mas sem

  13. Demand-driven volume rendering of terascale EM data

    Microsoft Academic Search

    Johanna Beyer; Markus Hadwiger; Won-Ki Jeong; Hanspeter Pfister; Jeff Lichtman

    2011-01-01

    In neuroscience, a very promising bottom-up approach to understanding how the brain works is built on acquiring and analyzing electron microscopy (EM) scans of brain tissue, an area known as Connectomics. This results in volume data of extremely high resolution of 3--5nm per pixel and 25--50nm slice thickness, overall leading to data sizes of many terabytes [Jeong et al. 2010].

  14. Pesquisas Baseadas na Localizao e na Orientao em Dispositivos Mveis

    E-print Network

    Carmo, Maria Beatriz

    Pesquisas Baseadas na Localização e na Orientação em Dispositivos Móveis Hugo Aguiar, Maria Beatriz Carmo, Paulo Pombinho, Ana Paula Afonso Departamento de Informática, Faculdade de Ciências, Universidade.di.fc.ul.pt,apa@di.fc.ul.pt Sumário A crescente utilização de dispositivos móveis e a sua evolução, com o surgimento de modelos

  15. EMS Mutagenesis in the Pea Aphid Acyrthosiphon pisum

    PubMed Central

    Tagu, Denis; Le Trionnaire, Gaël; Tanguy, Sylvie; Gauthier, Jean-Pierre; Huynh, Jean-René

    2014-01-01

    In aphids, clonal individuals can show distinct morphologic traits in response to environmental cues. Such phenotypic plasticity cannot be studied with classical genetic model organisms such as Caenorhabditis elegans or Drosophila melanogaster. The genetic basis of this biological process remain unknown, as mutations affecting this process are not available in aphids. Here, we describe a protocol to treat third-stage larvae with an alkylating mutagen, ethyl methanesulfonate (EMS), to generate random mutations within the Acyrthosiphon pisum genome. We found that even low concentrations of EMS were toxic for two genotypes of A. pisum. Mutagenesis efficiency was nevertheless assessed by estimating the occurrence of mutational events on the X chromosome. Indeed, any lethal mutation on the X-chromosome would kill males that are haploid on the X so that we used the proportion of males as an estimation of mutagenesis efficacy. We could assess a putative mutation rate of 0.4 per X-chromosome at 10 mM of EMS. We then applied this protocol to perform a small-scale mutagenesis on parthenogenetic individuals, which were screened for defects in their ability to produce sexual individuals in response to photoperiod shortening. We found one mutant line showing a reproducible altered photoperiodic response with a reduced production of males and the appearance of aberrant winged males (wing atrophy, alteration of legs morphology). This mutation appeared to be stable because it could be transmitted over several generations of parthenogenetic individuals. To our knowledge, this study represents the first example of an EMS-generated aphid mutant. PMID:24531730

  16. Position resolution and particle identification with the ATLAS EM calorimeter

    Microsoft Academic Search

    J. Colas; L. Di Ciaccio; M. El Kacimi; O. Gaumer; M. Gouanère; D. Goujdami; R. Lafaye; C. Le Maner; L. Neukermans; P. Perrodo; L. Poggioli; D. Prieur; H. Przysiezniak; G. Sauvage; I. Wingerter-Seez; R. Zitoun; F. Lanni; H. Ma; S. Rajagopalan; S. Rescia; H. Takai; A. Belymam; D. Benchekroun; M. Hakimi; A. Hoummada; E. Barberio; Y. S. Gao; L. Lu; R. Stroynowski; M. Aleksa; J. Beck Hansen; T. Carli; P. Fassnacht; F. Gianotti; L. Hervas; W. Lampl; B. Belhorma; J. Collot; M. L. Gallin-Martel; J. Y. Hostachy; F. Ledroit-Guillon; P. Martin; F. Ohlsson-Malek; S. Saboumazrag; S. Viret; M. Leltchouk; J. A. Parsons; M. Seman; F. Barreiro; J. Del Peso; L. Labarga; C. Oliver; S. Rodier; P. Barrillon; C. Benchouk; F. Djama; P. Y. Duval; F. Henry-Couannier; F. Hubaut; E. Monnier; P. Pralavorio; D. Sauvage; C. Serfon; S. Tisserant; J. Toth; D. Banfi; L. Carminati; D. Cavalli; G. Costa; M. Delmastro; M. Fanti; L. Mandelli; M. Mazzanti; G. F. Tartarelli; K. Kotov; A. Maslennikov; G. Pospelov; Yu. Tikhonov; C. Bourdarios; C. de La Taille; L. Fayard; D. Fournier; L. Iconomidou-Fayard; M. Kado; M. Lechowski; G. Parrour; P. Puzo; D. Rousseau; R. Sacco; N. Seguin-Moreau; L. Serin; G. Unal; D. Zerwas; B. Dekhissi; J. Derkaoui; A. El Kharrim; F. Maaroufi; A. Camard; D. Lacour; B. Laforge; I. Nikolic-Audit; Ph. Schwemling; H. Ghazlane; R. Cherkaoui El Moursli; A. Idrissi Fakhr-Eddine; M. Boonekamp; B. Mansoulié; P. Meyer; J. Schwindling; B. Lund-Jensen; Y. Tayalati

    2005-01-01

    In the years between 2000 and 2002 several pre-series and series modules of the ATLAS EM barrel and end-cap calorimeter were exposed to electron, photon and pion beams. The performance of the calorimeter with respect to its finely segmented first sampling has been studied. The polar angle resolution has been found to be in the range 50–60 (mrad)\\/E(GeV). The ?0

  17. Parameter estimation of superimposed signals using the EM algorithm

    Microsoft Academic Search

    MEIR FEDER; EHUD WEINSTEIN

    1988-01-01

    A computationally efficient algorithm for parameter estimation of superimposed signals based on the two-step iterative EM (estimate-and-maximize, with an E step and an M step) algorithm is developed. The idea is to decompose the observed data into their signal components and then to estimate the parameters of each signal component separately. The algorithm iterates back and forth, using the current

  18. Data management challenges in three-dimensional EM

    PubMed Central

    Patwardhan, Ardan; Carazo, José-Maria; Carragher, Bridget; Henderson, Richard; Heymann, J Bernard; Hill, Emma; Jensen, Grant J; Lagerstedt, Ingvar; Lawson, Catherine L; Ludtke, Steven J; Mastronarde, David; Moore, William J; Roseman, Alan; Rosenthal, Peter; Sorzano, Carlos-Oscar S; Sanz-García, Eduardo; Scheres, Sjors H W; Subramaniam, Sriram; Westbrook, John; Winn, Martyn; Swedlow, Jason R; Kleywegt, Gerard J

    2014-01-01

    This report describes the outcomes of the Data Management Challenges in 3D Electron Microscopy workshop. Key topics discussed include data models, validation and raw-data archiving. The meeting participants agreed that the EMDataBank should take the lead in addressing these issues, and concrete action points were agreed upon that will have a substantial impact on the accessibility of three-dimensional EM data in biology and medicine. PMID:23211764

  19. Da universidade para o mercado de trabalho em onze pases

    E-print Network

    Instituto de Sistemas e Robotica

    Universia está a ser lançado em várias instituições de ensino superior portuguesas. Rede ibero-americana regista por mês 195 mil ofertas ANA BELA FERREIRA Desde quinta-feira que os 23 mil alunos da Universidade a pró-rei- tora, Ana Nunes de Almeida. Ao aderir a esta plataforma, que con- centra não só ofertas

  20. A Biblioteca do IB em nmeros 2013 Acervo Total (publicaes)

    E-print Network

    Morandini, Andre C.

    Total atual Livros * 347 33.796 Teses 259 3.483 Títulos de Periódicos 2.132 Correntes ** 256 Não livros e teses) Biblioteca fornecedora 262 Biblioteca solicitante 100 Nº de cópias fornecidas 3 a Biblioteca comprou 156 livros e recebeu em doação 36. ** 256 por compra, 65 por doação e 78 por permuta. #12;

  1. ISSN 0103-9741 Monografia em Cincia da Computao

    E-print Network

    Endler, Markus

    DO RIO DE JANEIRO RUA MARQUÊS DE SÃO VICENTE, 225 - CEP 22451-900 RIO DE JANEIRO #12;Monografias em , Vânia M.P. Vidal2 José A. F. de Macêdo2 1 Department of Informatics ­ PUC-Rio ­ Rio de Janeiro, RJ-900 Rio de Janeiro RJ Brasil Tel. +55 21 3527-1516 Fax: +55 21 3527-1530 E-mail: bib-di@inf.puc-rio.br Web

  2. The boundary element method in EM-MWD

    Microsoft Academic Search

    Chen Zhiyu

    1992-01-01

    The linear boundary element method for electromagnetic fields is taken to deal with the excitation of a non-symmetrical electric\\u000a dipole in a lossy half space. A simple and practical algorithm is offered to the Measurement While Drilling with Electromagnetic\\u000a waves (EM-MWD). The calculation for two models under the low frequency limits are compared with the experiments and the results\\u000a calculated

  3. Supermarket eyes 1. 5-year payback on EMS

    Microsoft Academic Search

    Barber

    1982-01-01

    A Honeywell W-7000 load control system has cut energy consumption at a Pittsburgh Shop and Save by 13% and should pay for itself in about 1.5 years. An 18.4% increase in utility rates, however, lowered the electricity savings to 10%. The energy management system (EMS) performs duty-cycling, demand limiting, and time-of-day scheduling functions in addition to controlling 25 loads. Monitoring

  4. Improving EM&V for Energy Efficiency Programs (Fact Sheet)

    SciTech Connect

    Not Available

    2012-07-01

    This fact sheet describes the objectives of the U.S. Department of Energy Uniform Methods Project to bring consistency to energy savings calculations in U.S. energy efficiency programs. The U.S. Department of Energy (DOE) is developing a framework and a set of protocols for determining gross energy savings from energy efficiency measures and programs. The protocols represent a refinement of the body of knowledge supporting energy efficiency evaluation, measurement, and verification (EM&V) activities. They have been written by technical experts within the field and reviewed by industry experts. Current EM&V practice allows for multiple methods for calculating energy savings. These methods were developed to meet the needs of energy efficiency program administrators and regulators. Although they served their original objectives well, they have resulted in inconsistent and incomparable savings results - even for identical measures. The goal of the Uniform Methods Project is to strengthen the credibility of energy savings determinations by improving EM&V, increasing the consistency and transparency of how energy savings are determined.

  5. Conjoined Use of EM and NMR in RNA Structure Refinement

    PubMed Central

    Gong, Zhou; Schwieters, Charles D.; Tang, Chun

    2015-01-01

    More than 40% of the RNA structures have been determined using nuclear magnetic resonance (NMR) technique. NMR mainly provides local structural information of protons and works most effectively on relatively small biomacromolecules. Hence structural characterization of large RNAs can be difficult for NMR alone. Electron microscopy (EM) provides global shape information of macromolecules at nanometer resolution, which should be complementary to NMR for RNA structure determination. Here we developed a new energy term in Xplor-NIH against the density map obtained by EM. We conjointly used NMR and map restraints for the structure refinement of three RNA systems — U2/U6 small-nuclear RNA, genome-packing motif (?CD)2 from Moloney murine leukemia virus, and ribosome-binding element from turnip crinkle virus. In all three systems, we showed that the incorporation of a map restraint, either experimental or generated from known PDB structure, greatly improves structural precision and accuracy. Importantly, our method does not rely on an initial model assembled from RNA duplexes, and allows full torsional freedom for each nucleotide in the torsion angle simulated annealing refinement. As increasing number of macromolecules can be characterized by both NMR and EM, the marriage between the two techniques would enable better characterization of RNA three-dimensional structures. PMID:25798848

  6. The US DOE-EM International Program - 13004

    SciTech Connect

    Elmetti, Rosa R.; Han, Ana M.; Williams, Alice C. [Department of Energy, Office of Environmental Management, 1000 Independence Ave. SW, Washington, DC 20585 (United States)] [Department of Energy, Office of Environmental Management, 1000 Independence Ave. SW, Washington, DC 20585 (United States)

    2013-07-01

    The U.S. Department of Energy (DOE) Office of Environmental Management (EM) conducts international collaboration activities in support of U.S. policies and objectives regarding the accelerated risk reduction and remediation of environmental legacy of the nations' nuclear weapons program and government sponsored nuclear energy research. The EM International Program supported out of the EM Office of the Associate Principal Deputy Assistant Secretary pursues collaborations with foreign government organizations, educational institutions and private industry to assist in identifying technologies and promote international collaborations that leverage resources and link international experience and expertise. In fiscal year (FY) 2012, the International Program awarded eight international collaborative projects for work scope spanning waste processing, groundwater and soil remediation, deactivation and decommissioning (D and D) and nuclear materials disposition initiatives to seven foreign organizations. Additionally, the International Program's scope and collaboration opportunities were expanded to include technical as well as non-technical areas. This paper will present an overview of the on-going tasks awarded in FY 2012 and an update of upcoming international activities and opportunities for expansion into FY 2013 and beyond. (authors)

  7. Conjoined use of em and NMR in RNA structure refinement.

    PubMed

    Gong, Zhou; Schwieters, Charles D; Tang, Chun

    2015-01-01

    More than 40% of the RNA structures have been determined using nuclear magnetic resonance (NMR) technique. NMR mainly provides local structural information of protons and works most effectively on relatively small biomacromolecules. Hence structural characterization of large RNAs can be difficult for NMR alone. Electron microscopy (EM) provides global shape information of macromolecules at nanometer resolution, which should be complementary to NMR for RNA structure determination. Here we developed a new energy term in Xplor-NIH against the density map obtained by EM. We conjointly used NMR and map restraints for the structure refinement of three RNA systems - U2/U6 small-nuclear RNA, genome-packing motif (?CD)2 from Moloney murine leukemia virus, and ribosome-binding element from turnip crinkle virus. In all three systems, we showed that the incorporation of a map restraint, either experimental or generated from known PDB structure, greatly improves structural precision and accuracy. Importantly, our method does not rely on an initial model assembled from RNA duplexes, and allows full torsional freedom for each nucleotide in the torsion angle simulated annealing refinement. As increasing number of macromolecules can be characterized by both NMR and EM, the marriage between the two techniques would enable better characterization of RNA three-dimensional structures. PMID:25798848

  8. EMS-STARS: Emergency Medical Services "Superuser" Transport Associations: An Adult Retrospective Study.

    PubMed

    Hall, M Kennedy; Raven, Maria C; Hall, Jane; Yeh, Clement; Allen, Elaine; Rodriguez, Robert M; Tangherlini, Niels L; Sporer, Karl A; Brown, John F

    2015-01-01

    Abstract Objective. Emergency medical services (EMS) "superusers" -those who use EMS services at extremely high rates -have not been well characterized. Recent interest in the small group of individuals who account for a disproportionate share of health-care expenditures has led to research on frequent users of emergency departments and other health services, but little research has been done regarding those who use EMS services. To inform policy and intervention implementation, we undertook a descriptive analysis of EMS superusers in a large urban community. In this paper we compare EMS superusers to low, moderate, and high users to characterize factors contributing to EMS use. We also estimate the financial impact of EMS superusers. Methods. We conducted a retrospective cross-sectional study based on 1 year of data from an urban EMS system. Data for all EMS encounters with patients age ?18 years were extracted from electronic records generated on scene by paramedics. We identified demographic and clinical variables associated with levels of EMS use. EMS users were characterized by the annual number of EMS encounters: low (1), moderate (2-4), high (5-14), and superusers (?15). In addition, we performed a financial analysis using San Francisco Fire Department (SFFD) 2009 charge and reimbursement data. Results. A total of 31,462 adults generated 43,559 EMS ambulance encounters, which resulted in 39,107 transports (a 90% transport rate). Encounters for general medical reasons were common among moderate and high users and less frequent among superusers and low users, while alcohol use was exponentially correlated with encounter frequency. Superusers were significantly younger than moderate EMS users, and more likely to be male. The superuser group created a significantly higher financial burden/person than any other group, comprising 0.3% of the study population, but over 6% of annual EMS charges and reimbursements. Conclusions. In this retrospective study, adult EMS "superusers" emerged as a distinct, predominantly male population and their EMS encounters were associated with alcohol use. Continued analysis of this unique, high-cost, and frequently transported population will likely illuminate specific intervention strategies. PMID:25093273

  9. Does EMS Perceived Anatomic Injury Predict Trauma Center Need?

    PubMed Central

    Lerner, E. Brooke; Roberts, Jennifer; Guse, Clare E.; Shah, Manish N.; Swor, Robert; Cushman, Jeremy T.; Blatt, Alan; Jurkovich, Gregory J.; Brasel, Karen

    2013-01-01

    Objective Our objective was to determine the predictive value of the anatomic step of the 2011 Field Triage Decision Scheme for identifying trauma center need. Methods EMS providers caring for injured adults transported to regional trauma centers in 3 midsized communities were interviewed over two years. Patients were included, regardless of injury severity, if they were at least 18 years old and were transported by EMS with a mechanism of injury that was an assault, motor vehicle or motorcycle crash, fall, or pedestrian or bicyclist struck. The interview was conducted upon ED arrival and collected physiologic condition and anatomic injury data. Patients who met the physiologic criteria were excluded. Trauma center need was defined as non-orthopedic surgery within 24 hours, intensive care unit admission, or death prior to hospital discharge. Data were analyzed by calculating descriptive statistics including positive likelihood ratios (+LR) with 95% confidence intervals. Results 11,892 interviews were conducted. One was excluded because of missing outcome data and 1,274 were excluded because they met the physiologic step. EMS providers identified 1,167 cases that met the anatomic criteria, of which 307 (26%) needed the resources of a trauma center (38% sensitivity, 91% specificity, +LR 4.4; CI: 3.9 - 4.9). Criteria with a +LR ?5 were flail chest (9.0; CI: 4.1 - 19.4), paralysis (6.8; CI: 4.2 - 11.2), two or more long bone fractures (6.3; CI: 4.5 - 8.9), and amputation (6.1; CI: 1.5 - 24.4). Criteria with a +LR >2 and <5 were penetrating injury (4.8; CI: 4.2 - 5.6), and skull fracture (4.8; CI: 3.0 - 7.7). Only pelvic fracture (1.9; CI: 1.3 - 2.9) had a +LR less than 2. Conclusions The anatomic step of the Field Triage Guidelines as determined by EMS providers is a reasonable tool for determining trauma center need. Use of EMS perceived pelvic fracture as an indicator for trauma center need should be re-evaluated. PMID:23627418

  10. Inhomogeneous Media 3D EM Modeling with Integral Equation Method

    NASA Astrophysics Data System (ADS)

    di, Q.; Wang, R.; An, Z.; Fu, C.; Xu, C.

    2010-12-01

    In general, only the half space of earth is considered in electromagnetic exploration. However, for the long bipole source, because the length is close to the height of ionosphere and also most offsets between source and receivers are equal or larger than the height of ionosphere, the effect of ionosphere on the electromagnetic (EM) field should be considered when observation is carried at a very far (about several thousands kilometers) location away from the source. At this point the problem becomes one which should contain ionosphere, atmosphere and earth that is “earth-ionosphere” case. There are a few of literatures to report the electromagnetic field results which is including ionosphere, atmosphere and earth media at the same time. We firstly calculate the electromagnetic fields with the traditional controlled source (CSEM) configuration using integral equation (IE) method for a three layers earth-ionosphere model. The modeling results agree well with the half space analytical results because the effect of ionosphere for this small scale bipole source can be ignorable. The comparison of small scale three layers earth-ionosphere modeling and half space analytical resolution shows that the IE method can be used to modeling the EM fields for long bipole large offset configuration. In order to discuss EM fields’ characteristics for complicate earth-ionosphere media excited by long bipole source in the far-field and wave-guide zones, we first modeled the decay characters of electromagnetic fields for three layers earth-ionosphere model. Because of the effect of ionosphere, the earth-ionosphere electromagnetic fields’ decay curves with given frequency show that there should be an extra wave guide zone for long bipole artificial source, and there are many different characters between this extra zone and far field zone. They are: 1) the amplitudes of EM fields decay much slower; 2) the polarization patterns change; 3) the positions better to measure Zxy and Zyx change; 4) there exits the polarization ellipse of electric and magnetic fields; 5) the long axis direction of the polarization ellipse in wave guide zone changes comparing to quasi static EM fields. In order to further model the EM fields for complex inhomogeneous media, we conducted the EM fields modeling for Biyang depressed basin of China. The bottom depth of the oil basin is about 8km. We added one ionosphere layer with thickness 100km and resistivity 104 Ohm-m and one atmosphere layer with thickness 100km and resistivity 1014 Ohm-m over the solid earth surface during the forward modeling. For easily to compare with the 2D seismic exploration result, we conducted the apparent resistivity modeling of equatorial array for the same survey line as seismic did for an 50km long bipole source with offset 400km and the same frequencies as that used for above three layers model. The modeling apparent resistivity pseudo-section has clearly shown the oil basin geology structure.

  11. UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM TECNOLOGIA AMBIENTAL E

    E-print Network

    Maier, Rudolf Richard

    UNIVERSIDADE DE BRASÍLIA PROGRAMA DE P�S-GRADUA��O EM TECNOLOGIA AMBIENTAL E RECURSOS HÍDRICOS EDITAL No. 1/2011 SELE��O DE CANDIDATOS �S VAGAS DO PROGRAMA DE P�S-GRADUA��O EM TECNOLOGIA AMBIENTAL E Coordenador do Programa de Pós-Graduação em Tecnologia Ambiental e Recursos Hídricos da Universidade de

  12. UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM PATOLOGIA MOLECULAR

    E-print Network

    Maier, Rudolf Richard

    UNIVERSIDADE DE BRASÍLIA PROGRAMA DE P�S-GRADUA��O EM PATOLOGIA MOLECULAR EDITAL PPGPM Nº. 1/2013 SELE��O DE CANDIDATOS �S VAGAS DO PROGRAMA DE P�S-GRADUA��O EM PATOLOGIA MOLECULAR PARA OS CURSOS DE Programa de Pós-Graduação em Patologia Molecular, no uso de suas atribuições legais, torna público e

  13. UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM BIOLOGIA MOLECULAR

    E-print Network

    Maier, Rudolf Richard

    1 UNIVERSIDADE DE BRASÍLIA PROGRAMA DE P�S-GRADUA��O EM BIOLOGIA MOLECULAR EDITAL No. 02/2010 SELE��O DE CANDIDATOS �S VAGAS DO PROGRAMA DE P�S-GRADUA��O EM BIOLOGIA MOLECULAR PARA OS CURSOS DE Programa de Pós Graduação em Biologia Molecular, no uso de suas atribuições legais, torna público e

  14. UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM BIOLOGIA MOLECULAR

    E-print Network

    Lucero, Jorge Carlos

    1 UNIVERSIDADE DE BRASÍLIA PROGRAMA DE P�S-GRADUA��O EM BIOLOGIA MOLECULAR EDITAL No. 02/2011 SELE��O DE CANDIDATOS �S VAGAS DO PROGRAMA DE P�S-GRADUA��O EM BIOLOGIA MOLECULAR PARA OS CURSOS DE Programa de Pós Graduação em Biologia Molecular, no uso de suas atribuições legais, torna público e

  15. UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM BIOLOGIA ANIMAL

    E-print Network

    Maier, Rudolf Richard

    UNIVERSIDADE DE BRASÍLIA PROGRAMA DE P�S-GRADUA��O EM BIOLOGIA ANIMAL EDITAL No. 01/2011 SELE��O DE CANDIDATOS �S VAGAS DO PROGRAMA DE P�S-GRADUA��O EM BIOLOGIA ANIMAL PARA OS CURSOS DE MESTRADO ACAD�MICO E-Graduação em Biologia Animal, no uso de suas atribuições legais, torna público e estabelece as normas do

  16. UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM BIOLOGIA ANIMAL EDITAL No. 02/2011

    E-print Network

    Lucero, Jorge Carlos

    UNIVERSIDADE DE BRASÍLIA PROGRAMA DE P�S- GRADUA��O EM BIOLOGIA ANIMAL EDITAL No. 02/2011 SELE��O DE CANDIDATOS �S VAGAS DO PROGRAMA DE P�S- GRADUA��O EM BIOLOGIA ANIMAL PARA OS CURSOS DE MESTRADO Pós-Graduação em Biologia Animal, no uso de suas atribuições legais, torna público e estabelece

  17. UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM BIOLOGIA MICROBIANA

    E-print Network

    Lucero, Jorge Carlos

    1 UNIVERSIDADE DE BRASÍLIA PROGRAMA DE P�S-GRADUA��O EM BIOLOGIA MICROBIANA EDITAL No. 01/2011 SELE��O DE CANDIDATOS �S VAGAS DO PROGRAMA DE P�S-GRADUA��O EM BIOLOGIA MICROBIANA PARA OS CURSOS DE Programa de Pós Graduação em Biologia Microbiana, no uso de suas atribuições legais, torna público e

  18. PROGRAMA DE PS-GRADUAO EM FILOSOFIA DA UNIVERSIDADE DE BRASLIA

    E-print Network

    Lucero, Jorge Carlos

    PROGRAMA DE P�S-GRADUA��O EM FILOSOFIA DA UNIVERSIDADE DE BRASÍLIA EDITAL PPG EM FILOSOFIA Nº 1/2011 SELE��O DE CANDIDATOS AO PROGRAMA DE P�S-GRADUA��O EM FILOSOFIA: CURSO DE MESTRADO ACAD�MICO, PARA Filosofia, no uso de suas atribuições legais, torna público e estabelece as normas do processo seletivo para

  19. EM-Cube: an architecture for low-cost real-time volume rendering

    Microsoft Academic Search

    Rtindy Osborne; Hanspeter Pfister; Hugh Lauer; TakaHide Ohkami; Neil McKenzie; Sarah Gibson; Wally Hiatt

    1997-01-01

    EM-Cube is a VLSI architecture for low-cost, high quality volume rendering at full video frame rates. Derived from the Cube-4 ar- chitecture developed at SUNY at Stony Brook, EM-Cube computes sample points and gradients on-the-fly to project 3-dimensional vol- ume data onto 2-dimensional images with realistic lighting and shading. A modest rendering system based on EM-Cube consists of a PCI

  20. EMS-CO2 Welding: A New Approach to Improve Droplet Transfer Characteristics and Welding Formation

    Microsoft Academic Search

    Jian Luo; Qian Luo; Xiangjie Wang; Xiaochuan Wang

    2010-01-01

    In this article, to improve the stability of droplet transfer and reduce the spatter of pure carbon dioxide gas shield welding (CO2 welding), we propose a new welding method called EMS-CO2 welding by applying an additional longitudinal electromagnetic field to a CO2 welding process (abbr. EMS-CO2 welding). The characteristics of droplet transfer, welding formation and microstructure between EMS-CO2 welding and

  1. A Cramér-Rao Bound Characterization of the EM-Algorithm Mean Speed of Convergence

    Microsoft Academic Search

    Cédric Herzet; Valéry Ramon; Alexandre Renaux; Luc Vandendorpe

    2008-01-01

    This paper deals with the mean speed of convergence of the expectation-maximization (EM) algorithm. We show that the asymptotic behavior (in terms of the number of observations) of the EM algorithm can be characterized as a function of the Cramer-Rao bounds (CRBs) associated to the so-called incomplete and complete data sets defined within the EM-algorithm framework. We particularize our result

  2. Hanford site performance summary - EM funded programs (formerly known as Hanford site performance summary)

    Microsoft Academic Search

    1996-01-01

    Hanford fiscal-year-to-date (FYTD) schedule performance remains unfavorable with a three percent schedule variance (-$36.6 million*) and a four percent cost variance (+$47.5 million). The schedule var-iance is attributed to EM-30, Office of Waste Management (-$21.6 million), EM-40, Office of Environmental Restoration (-$7.7 million), and EM-60, Office of Nuclear Material and Facility Stabilization (-$5.3 million). Sixty-one enforceable agreement milestones were scheduled

  3. Detecção inesperada de efeitos de lentes fracas em grupos de galáxias pouco luminosos em raios-X

    NASA Astrophysics Data System (ADS)

    Carrasco, R.; Mendes de Oliveira, C.; Sodrã©, L., Jr.; Lima Neto, G. B.; Cypriano, E. S.; Lengruber, L. L.; Cuevas, H.; Ramirez, A.

    2003-08-01

    Obtivemos, como parte do programa de verificação científica do GMOS Sul, imagens profundas de três grupos de galáxias: G97 e G102 (z~0,4) e G124 (z = 0,17). Esses alvos foram selecionados a partir do catálogo de fontes extensas de Vikhlinin (1998), por terem luminosidades em raios X menores que 3´1043 ergs s-1, valor cerca de uma ou duas ordens de grandeza inferior ao de aglomerados de galáxias. O objetivo primário dessas observações é o estudo da evolução de galáxias em grupos. Grupos são ambientes menos densos que aglomerados, contêm a grande maioria das galáxias do Universo mas que, até o momento, foram estudados detalhadamente apenas no Universo local (z~0). Com esses dados efetuamos uma análise estatística da distorção na forma das galáxias de fundo (lentes gravitacionais fracas) como forma de inferir o conteúdo e a distribuição de massa nesses grupos apesar de que, em princípio, esse efeito não deveria ser detectado uma vez que os critérios de seleção adotados previlegiam sistemas de baixa massa. De fato, para G124 obtivemos apenas um limite superior para sua massa que é compatível com sua luminosidade em raios X. De modo contrário e surpreendente, os objetos G102 e G097, aparentam ter massas que resultariam em dispersões de velocidade maiores que 1000 km s-1, muito maiores do que se espera para grupos de galáxias. Com efeito, para G097 obtivemos, a partir de dados do satélite XMM, uma estimativa para a temperatura do gás intragrupo de kT = 2,6 keV, que é tipica de sistemas com dispersões de velocidade de ~ 600 km s-1, bem característica de grupos. Essas contradições aparentes entre lentes fracas e raios X podem ser explicadas de dois modos: i) a massa obtida por lentes estaria sobreestimada devido à superposição de estruturas massivas ao longo da linha de visada ou ii) a temperatura do gás do meio intra-grupo reflete o potencial gravitacional de estruturas menores que estariam se fundindo para formar uma estrutura maior.

  4. Covariance Matrix Estimation for the Cryo-EM Heterogeneity Problem*

    PubMed Central

    Katsevich, E.; Katsevich, A.; Singer, A.

    2015-01-01

    In cryo-electron microscopy (cryo-EM), a microscope generates a top view of a sample of randomly oriented copies of a molecule. The problem of single particle reconstruction (SPR) from cryo-EM is to use the resulting set of noisy two-dimensional projection images taken at unknown directions to reconstruct the three-dimensional (3D) structure of the molecule. In some situations, the molecule under examination exhibits structural variability, which poses a fundamental challenge in SPR. The heterogeneity problem is the task of mapping the space of conformational states of a molecule. It has been previously suggested that the leading eigenvectors of the covariance matrix of the 3D molecules can be used to solve the heterogeneity problem. Estimating the covariance matrix is challenging, since only projections of the molecules are observed, but not the molecules themselves. In this paper, we formulate a general problem of covariance estimation from noisy projections of samples. This problem has intimate connections with matrix completion problems and high-dimensional principal component analysis. We propose an estimator and prove its consistency. When there are finitely many heterogeneity classes, the spectrum of the estimated covariance matrix reveals the number of classes. The estimator can be found as the solution to a certain linear system. In the cryo-EM case, the linear operator to be inverted, which we term the projection covariance transform, is an important object in covariance estimation for tomographic problems involving structural variation. Inverting it involves applying a filter akin to the ramp filter in tomography. We design a basis in which this linear operator is sparse and thus can be tractably inverted despite its large size. We demonstrate via numerical experiments on synthetic datasets the robustness of our algorithm to high levels of noise. PMID:25699132

  5. EM-21 Retrieval Knowledge Center: Waste Retrieval Challenges

    SciTech Connect

    Fellinger, Andrew P.; Rinker, Michael W.; Berglin, Eric J.; Minichan, Richard L.; Poirier, Micheal R.; Gauglitz, Phillip A.; Martin, Bruce A.; Hatchell, Brian K.; Saldivar, Eloy; Mullen, O Dennis; Chapman, Noel F.; Wells, Beric E.; Gibbons, Peter W.

    2009-04-10

    EM-21 is the Waste Processing Division of the Office of Engineering and Technology, within the U.S. Department of Energy’s (DOE) Office of Environmental Management (EM). In August of 2008, EM-21 began an initiative to develop a Retrieval Knowledge Center (RKC) to provide the DOE, high level waste retrieval operators, and technology developers with centralized and focused location to share knowledge and expertise that will be used to address retrieval challenges across the DOE complex. The RKC is also designed to facilitate information sharing across the DOE Waste Site Complex through workshops, and a searchable database of waste retrieval technology information. The database may be used to research effective technology approaches for specific retrieval tasks and to take advantage of the lessons learned from previous operations. It is also expected to be effective for remaining current with state-of-the-art of retrieval technologies and ongoing development within the DOE Complex. To encourage collaboration of DOE sites with waste retrieval issues, the RKC team is co-led by the Savannah River National Laboratory (SRNL) and the Pacific Northwest National Laboratory (PNNL). Two RKC workshops were held in the Fall of 2008. The purpose of these workshops was to define top level waste retrieval functional areas, exchange lessons learned, and develop a path forward to support a strategic business plan focused on technology needs for retrieval. The primary participants involved in these workshops included retrieval personnel and laboratory staff that are associated with Hanford and Savannah River Sites since the majority of remaining DOE waste tanks are located at these sites. This report summarizes and documents the results of the initial RKC workshops. Technology challenges identified from these workshops and presented here are expected to be a key component to defining future RKC-directed tasks designed to facilitate tank waste retrieval solutions.

  6. A compulsator driven rapid-fire EM-gun

    SciTech Connect

    Pratap, S.B.; Bird, W.L.

    1984-03-01

    A compulsator-driven railgun is an attractive alternative to the homopolar generator-inductor-switch configuration, especially for repetitive duty. A conceptual design of a rapid-fire EM-gun system is presented. The generator is sized to accelerate a 0.08-kg projectile to 2 to 3 km/s at a 60 pulse-per-second repetition rate. Initial design parameters are discussed, and example current and velocity waveforms are given. The generator is discharged at the proper phase angle to provide a current zero just as the projectile exits the muzzle of the railgun.

  7. A compulsator driven rapid-fire EM gun

    NASA Astrophysics Data System (ADS)

    Pratap, S. B.; Bird, W. L.; Godwin, G. L.; Weldon, W. F.

    1984-03-01

    A computator-driven railgun is an attractive alternative to the homopolar generator-inductor-switch configuration, especially for repetitive duty. A conceptual design of rapid-fire EM-gun system is presented. The generator is sized to accelerate a 0.08-kg projectile to 2 to 3 km/s at a 60 pulse-per-second repetition rate. Initial design parameters are discussed, and example current and velocity waveforms are given. The generator is discharged at the proper phase angle to provide a current zero just as the projectile exits the muzzle of the railgun.

  8. Caucasicosides E-M, furostanol glycosides from Helleborus caucasicus.

    PubMed

    Muzashvili, Tamar; Perrone, Angela; Napolitano, Assunta; Kemertelidze, Ether; Pizza, Cosimo; Piacente, Sonia

    2011-12-01

    Nine furostanol glycosides, namely caucasicosides E-M, were isolated from the MeOH extract of the leaves of Helleborus caucasicus, along with 11 known compounds including nine furostanol glycosides, a bufadienolide and an ecdysteroid. Their structures were established by the extensive use of 1D and 2D NMR experiments along with ESIMS(n) analyses. The steroidal composition of leaves of H. caucasicus shows as particular feature the occurrence of steroidal compounds belonging to the 5? series, unusual for Helleborus species, and in particular, caucasicosides F-H are based on a 5?-polyhydroxylated steroidal aglycon never reported before. PMID:21893324

  9. Supermarket eyes 1. 5-year payback on EMS

    SciTech Connect

    Barber, J.

    1982-05-03

    A Honeywell W-7000 load control system has cut energy consumption at a Pittsburgh Shop and Save by 13% and should pay for itself in about 1.5 years. An 18.4% increase in utility rates, however, lowered the electricity savings to 10%. The energy management system (EMS) performs duty-cycling, demand limiting, and time-of-day scheduling functions in addition to controlling 25 loads. Monitoring information gathered by the manufacturer allows a weekly performance comparison of the system. (DCK)

  10. ARTIGO INTERNET Bioengenharia de Clulas Estaminais e Redes de Comunicaes em debate

    E-print Network

    Instituto de Sistemas e Robotica

    NewsSearch ARTIGO INTERNET Bioengenharia de Células Estaminais e Redes de Comunicações em debate://www.cienciapt.net/pt/in ... Bioengenharia de Células Estaminais e Redes de Comunicações em debate no IST Taguspark Com o objectivo de tecnológicas de vanguarda. Temáticas como a Bioengenharia de Células Estaminais, Redes de Comunicações, Gestão

  11. Reserva de Recursos e Qualidade de Servio em Redes de Computadores de Dbito Elevado

    E-print Network

    Monteiro, Edmundo

    Reserva de Recursos e Qualidade de Serviço em Redes de Computadores de Débito Elevado Elisabete trabalho insere-se na área das redes de comunicação de alta velocidade com garantia de qualidade de serviço desenvolvimento e a integração de mecanismos de garantia de qualidade de serviço (QoS) em protocolos de rede e de

  12. SciMulator: Um Ambiente de Simulao de Workflows Cientficos em Redes P2P*

    E-print Network

    Paris-Sud XI, Université de

    SciMulator: Um Ambiente de Simulação de Workflows Científicos em Redes P2P* Jonas Dias1 , Carla networks. Resumo. O crescimento dos experimentos científicos em larga escala motiva a busca por ambientes paradigma Many Task Computing (MTC). Ambientes Peer-to-Peer (P2P) podem atender esta demanda, pelo fácil

  13. Efeitos da suplementação aguda de aspartato de arginina na fadiga muscular em voluntários treinados

    Microsoft Academic Search

    Ricardo Pombo Sales; Carlos Eduardo César Miné; Andréia Dellú Franco; Érika Lima Rodrigues; Renato de Souza e Silva; José Carlos Cogo; Rodrigo A. B. Lopes-Martins; Rodrigo Lazo Osorio; Wellington Ribeiro

    2005-01-01

    RESUMO A atividade física influi em mecanismos específicos responsá- veis pela redução da produção de força e conseqüentemente à fadiga. A preocupação em melhorar o desempenho físico tem sido propostos; observamos que estudos dão atenção para reduzir acú- mulos dos metabólitos que diminuem a fadiga durante o exercício físico intenso, usando aminoácidos conhecidos por induzir mudan- ças metabólicas, entre eles

  14. EM ALGORITHM FOR SPARSE REPRESENTATION-BASED IMAGE INPAINTING M.J. Fadili

    E-print Network

    Paris-Sud XI, Université de

    EM ALGORITHM FOR SPARSE REPRESENTATION-BASED IMAGE INPAINTING M.J. Fadili GREYC UMR CNRS 6072 10 Bd-sur-Yvette France ABSTRACT We introduce an expectation-maximization (EM) algorithm for image inpainting based be viewed as an interpolation or a desocclusion problem. The classical image inpainting problem can

  15. Influence of Cu ++ and Zn ++ ions on the effects of ethyl methanesulfonate (EMS) on chromosomes

    Microsoft Academic Search

    J. Moutschen-Dahmen; M. Moutschen-Dahmen

    1963-01-01

    Résumé La capacité de l'EMS de casser les chromosomes n'existe que lorsque des ions ont été ajoutés pendant les traitements. A ce point de vue, Cu++ et Zn++ se révèlent très efficaces. Cette réaction dépend du pH et varie avec la concentration ionique et la concentration d'EMS. On donne une explication probable de ces faits.

  16. Covariance Structure Model Fit Testing under Missing Data: An Application of the Supplemented EM Algorithm

    ERIC Educational Resources Information Center

    Cai, Li; Lee, Taehun

    2009-01-01

    We apply the Supplemented EM algorithm (Meng & Rubin, 1991) to address a chronic problem with the "two-stage" fitting of covariance structure models in the presence of ignorable missing data: the lack of an asymptotically chi-square distributed goodness-of-fit statistic. We show that the Supplemented EM algorithm provides a convenient…

  17. Global Convergence of the EM Algorithm for Unconstrained Latent Variable Models with Categorical Indicators

    ERIC Educational Resources Information Center

    Weissman, Alexander

    2013-01-01

    Convergence of the expectation-maximization (EM) algorithm to a global optimum of the marginal log likelihood function for unconstrained latent variable models with categorical indicators is presented. The sufficient conditions under which global convergence of the EM algorithm is attainable are provided in an information-theoretic context by…

  18. Modelao da Integrao em Arquitecturas de Sistemas de Informao Andr Vasconcelos

    E-print Network

    Modelação da Integração em Arquitecturas de Sistemas de Informação André Vasconcelos Instituto.tribolet@ceo.inesc.pt #12;Modelação da Integração em Arquitecturas de Sistemas de Informação Resumo No passado, na definição de arquitecturas de sistemas de informação (ASI) a integração era considerada uma questão de segunda

  19. UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM ANTROPOLOGIA SOCIAL

    E-print Network

    Maier, Rudolf Richard

    UNIVERSIDADE DE BRASÍLIA PROGRAMA DE PÓS-GRADUAÇÃO EM ANTROPOLOGIA SOCIAL EDITAL No. 02 ANTROPOLOGIA SOCIAL PARA O CURSO DE DOUTORADO PARA O PRIMEIRO PERÍODO LETIVO DE 2012 1. PREÂMBULO 1.1 O Coordenador do Programa de Pós-Graduação em Antropologia Social, no uso de suas atribuições legais, torna

  20. UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM ANTROPOLOGIA SOCIAL

    E-print Network

    Maier, Rudolf Richard

    UNIVERSIDADE DE BRASÍLIA PROGRAMA DE PÓS-GRADUAÇÃO EM ANTROPOLOGIA SOCIAL PPGAS EDITAL No .01 ANTROPOLOGIA SOCIAL PARA O CURSO DE MESTRADO ACADÊMICO PARA O PRIMEIRO PERÍODO LETIVO DE 2012 1. PREÂMBULO 1.1. O Coordenador do Programa de Pós-Graduação em Antropologia Social - PPGAS, no uso de suas

  1. UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM ANTROPOLOGIA SOCIAL

    E-print Network

    Lucero, Jorge Carlos

    UNIVERSIDADE DE BRASÍLIA PROGRAMA DE PÓS-GRADUAÇÃO EM ANTROPOLOGIA SOCIAL EDITAL No. 02 ANTROPOLOGIA SOCIAL PARA O CURSO DE DOUTORADO PARA O PRIMEIRO PERÍODO LETIVO DE 2013 1. PREÂMBULO 1.1 O Coordenador do Programa de Pós-Graduação em Antropologia Social, no uso de suas atribuições legais, torna

  2. UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM ANTROPOLOGIA SOCIAL

    E-print Network

    Maier, Rudolf Richard

    UNIVERSIDADE DE BRASÍLIA PROGRAMA DE PÓS-GRADUAÇÃO EM ANTROPOLOGIA SOCIAL EDITAL No. 03 ANTROPOLOGIA SOCIAL PARA O CURSO DE MESTRADO PARA O PRIMEIRO PERÍODO LETIVO DE 2011 O Coordenador do Programa de Pós-Graduação em Antropologia, no uso de suas atribuições legais, torna público e estabelece

  3. UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM ANTROPOLOGIA SOCIAL

    E-print Network

    Maier, Rudolf Richard

    UNIVERSIDADE DE BRASÍLIA PROGRAMA DE PÓS-GRADUAÇÃO EM ANTROPOLOGIA SOCIAL EDITAL No. 05 ANTROPOLOGIA SOCIAL PARA O CURSO DE DOUTORADO PARA O PRIMEIRO PERÍODO LETIVO DE 2013 1. PREÂMBULO 1.1 O Coordenador do Programa de Pós-Graduação em Antropologia Social, no uso de suas atribuições legais, torna

  4. UNIVERSIDADE DE BRASLIA PROGRAMA DE PS-GRADUAO EM ANTROPOLOGIA SOCIAL

    E-print Network

    Lucero, Jorge Carlos

    UNIVERSIDADE DE BRASÍLIA PROGRAMA DE PÓS-GRADUAÇÃO EM ANTROPOLOGIA SOCIAL PPGAS EDITAL No 01 ANTROPOLOGIA SOCIAL PARA O CURSO DE MESTRADO ACADÊMICO PARA O PRIMEIRO PERÍODO LETIVO DE 2013 1. PREÂMBULO 1.1. O Coordenador do Programa de Pós-Graduação em Antropologia Social - PPGAS, no uso de suas

  5. DIAGNÓSTICO DE FALHAS EM MÁQUINAS ROTATIVAS ATRAVÉS DA ANÁLISE DA VIBRAÇÃO TORCIONAL

    Microsoft Academic Search

    Evaldo Khater

    RESUMO Os eixos, quando transmitem torque, agem como molas torcionais, além da flexão. Quando há variação cíclica no torque transmitido podem aparecer vibrações torcionais forçadas, que dependendo das freqüências naturais do sistema poderão causar ressonância, caso em que o eixo poderá oscilar em amplitudes suficientemente elevadas para produzir falhas. O presente trabalho apresenta técnicas de medição e análise de vibração

  6. GESTÃO DO CONHECIMENTO ORGANIZACIONAL ESTUDO DE CASO EM UMA ORGANIZAÇÃO PÚBLICA

    Microsoft Academic Search

    Lourdes Maria Ritt

    1. Introdução Este estudo refere-se ao processo de gestão do conhecimento organizacional na área operacional de uma organização pública e é parte integrante da dissertação de mestrado em Ciências Empresariais pela Universidade Fernando Pessoa de Portugal. Os objetivos do estudo foi identificar por meio de pesquisa como a organização pública gere o conhecimento organizacional e, especificamente, em que consiste este

  7. Monitoring of earthquake processes by passive and active EM methods. An observational study

    Microsoft Academic Search

    G. Zhao; Z. Yan; W. Lifeng; J. Wang; J. Tang; Q. Xiao; X. Chen; J. Zhao

    2009-01-01

    Three experiments are carried out from the Institute of Geology, CEA research group to study earthquake process by using different electromagnetic (EM) methods in recent years. Several earthquakes did occur during the observational period and EM anomalies were recorded before the main shocks. Our observation at 20 km away from the epicenter of Zhangbei MS6.2 earthquake of January 10, 1998

  8. ERRÂNCIAS SERTANEJAS: AS MIGRAÇÕES CAMPO-CIDADE EM MONTES CLAROS NO NORTE DE MINAS GERAIS

    Microsoft Academic Search

    Andrea Maria Narciso; Carlos Rodriques B. Brandao

    2008-01-01

    Este trabalho apresenta reflexões sobre a dinâmica interna rural no Brasil com ênfase para o Norte de Minas Gerais. A reflexão sobre a migração rural na cidade do sertão de Minas Gerais corrobora a hipótese das migrações estarem ocorrendo cada vez mais dentro das próprias regiões, em função do crescimento incentivado pelo Estado em algumas cidades e também a desilusão

  9. Initial value approach to the EM induction in a heterogeneous sphere: Validation of the method

    E-print Network

    Velímsky, Jakub

    of electromagnetic induction is reformulated in the weak sense. The magnetic #12;eld is parameterized by vectorInitial value approach to the EM induction in a heterogeneous sphere: Validation of the method J, Czech Republic. Abstract. A newly developed initial-value formulation of the EM induction problem

  10. Polímeros condutores intrínsecos e seu potencial em blindagem de radiações eletromagnéticas

    Microsoft Academic Search

    Roselena Faez; Mirabel C. Rezende; Inácio M. Martin; Marco-A. De Paoli

    2000-01-01

    Resumo: A procura por novos materiais que possuam propriedades magnéticas e dielétricas adequadas ao uso em absorvedores de radiação eletromagnética é de grande importância. Dentre os materiais em estudo, os polímeros condutores têm sido aplicados como centros de absorção de radiação, devido à possibilidade de variação da sua condutividade com a freqüência da radiação das ondas incidentes, sendo esta pesquisa

  11. Comportamento de Pantala flavescens (Odonata, Anisoptera, Libellulidae) e perda do investimento reprodutivo em áreas antropizadas

    Microsoft Academic Search

    Antonia Figueira Van de Koken

    2007-01-01

    RESUMO: Pantala flavescens é uma libélula exofítica, territorialista e migratória. Devido ao comportamento migratório, a ocorrência desta espécie em áreas não alagadas é comum. No entanto, a presença de P. flavescens em áreas de estacionamento de veículos e o registro de eventos de oviposição sobre as latarias de automóveis não é bem entendida. O presente trabalho apresenta dados comportamentais de

  12. ANÁLISE DE INVESTIMENTOS EM GERAÇÃO HIDRÁULICA UTILIZANDO A TEORIA DE OPÇÕES REAIS

    Microsoft Academic Search

    J. C. CAMINHA NORONHA; J. W. MARANGON LIMA; T. G. LEITE FERREIRA

    1. RESUMO Este trabalho apresenta uma metodologia de análise de investimentos em geração de energia elétrica utilizando Teoria de Opções Reais. Particularmente, é avaliada a oportunidade de investimento em geração hidráulica a ser comercializada no leilão de energia nova utilizando-se da alternativa de financiamento do Programa de Financiamento de Geração de Energia Elétrica (Energia Nova) do BNDES. Como os empreendimentos

  13. TRANSTORNO DE DÉFICIT DE ATENÇÃO\\/HIPERATIVIDADE EM ADULTOS - ASPECTOS CLÍNICOS

    Microsoft Academic Search

    Maria da Graça; Tanori de Castro; Rosemeri Siqueira Pedroso; Renata Brasil Araujo

    2009-01-01

    O Transtorno de Déficit de Atenção\\/hiperatividade (TDAH), reconhecido como podendo persistir na vida adulta apenas na década de 80, causa considerável comprometimento no desempenho social, ocupacional e pessoal do indivíduo, além apresentar-se em comorbidade com outros quadros clínicos. Tendo em vista a prevalência e as limitações causadas pelo TDAH o objetivo deste estudo foi realizar uma revisão da literatura acerca

  14. Comorbidades do transtorno de déficit de atenção e hiperatividade em crianças escolares

    Microsoft Academic Search

    Marianne de Aguiar Possa; Lucas Spanemberg; Ana Guardiola

    2005-01-01

    RESUMO - O b j e t i v o: Avaliar a freqüência de transtorno de conduta (TC), transtorno desafiador opositivo ( T D O ) e transtorno obsessivo-compulsivo (TOC) em crianças com transtorno de déficit de atenção e hiperatividade ( T D A H ) .M é t o d o: Estudo realizado em crianças de 7 a 11

  15. Developing State and National Evaluation Infrastructures- Guidance for the Challenges and Opportunities of EM&V

    SciTech Connect

    Schiller, Steven R.; Goldman, Charles A.

    2011-06-24

    Evaluating the impacts and effectiveness of energy efficiency programs is likely to become increasingly important for state policymakers and program administrators given legislative mandates and regulatory goals and increasing reliance on energy efficiency as a resource. In this paper, we summarize three activities that the authors have conducted that highlight the expanded role of evaluation, measurement and verification (EM&V): a study that identified and analyzed challenges in improving and scaling up EM&V activities; a scoping study that identified issues involved in developing a national efficiency EM&V standard; and lessons learned from providing technical assistance on EM&V issues to states that are ramping up energy efficiency programs. The lessons learned are summarized in 13 EM&V issues that policy makers should address in each jurisdiction and which are listed and briefly described. The paper also discusses how improving the effectiveness and reliability of EM&V will require additional capacity building, better access to existing EM&V resources, new methods to address emerging issues and technologies, and perhaps foundational documents and approaches to improving the credibility and cross jurisdictional comparability of efficiency investments. Two of the potential foundational documents discussed are a national EM&V standard or resource guide and regional deemed savings and algorithm databases.

  16. MÉTODOS DE COLHEITA DE SEMENTES EM Stylosanthes capitata vog. in Linnaea

    Microsoft Academic Search

    RICARDO CARMONA; JOHN ELLIOTT FERGUSON; MANOEL DE SOUZA

    RESUMO. Testaram-se métodos de colheita de sementes em S. capitata CIAT- 1693, com relação a rendimento, qualidade de sementes e implicações econômicas, em Carimágua, Colômbia, no ano de 1983. Os tratamentos dividiram-se nos grupos: A - Totalmente manual, B - Totalmente mecânica, C - Corte manual e trilha mecânica, D - Corte mecânico e trilha manual. Testaram- se variações no

  17. A Fully Automated Approach to Segmentation of Irregularly Shaped Cellular Structures in EM Images

    Microsoft Academic Search

    Aurélien Lucchi; Kevin Smith; Radhakrishna Achanta; Vincent Lepetit; Pascal Fua

    2010-01-01

    While there has been substantial progress in segmenting natural im- ages, state-of-the-art methods that perform well in such tasks unfortunately tend to underperform when confronted with the different challenges posed by electron microscope (EM) data. For example, in EM imagery of neural tissue, numerous cells and subcellular structures appear within a single image, they exhibit irreg- ular shapes that cannot

  18. Hydrodynamics and Morphology in the Ems/Dollard Estuary: Review of Models, Measurements,

    E-print Network

    Talke, Stefan

    of CO2 is expected to increase sea level by 30 cm, while the significant wind speed and wave heights processes in the Ems. Deepening and streamlining the Ems River and shipping channel between the 1960s and 1990s decreased the hydraulic roughness and increased the tidal range in the river above Emden

  19. EMS Surv. Math. Sci. x (201x), xxxxxx DOI 10.4171/EMSS/x

    E-print Network

    EMS Surv. Math. Sci. x (201x), xxx­xxx DOI 10.4171/EMSS/x EMS Surveys in Mathematical Sciences c on partial differential equations. The latter brought a significant innovation in a field previously, Penn State University, U.S.A. E-mail: bressan@math.psu.edu S. Cani´c, Department of Mathematics

  20. The Greek EMS-SCADA: from the contractor to the user

    Microsoft Academic Search

    D. T. Askounis; E. Kalfaoglou

    2000-01-01

    The national electric utility of Greece has installed and put in operation a modern energy management system (EMS). This paper presents the evolution of the supervisory control and data acquisition (SCADA) system of the EMS during its two years of commercial operation. It classifies all the improvements implemented during this period in 3 areas: telecommunications, man-machine interface and core SCADA

  1. EDITAL N 01/2012 Em 29 de maio de 2012

    E-print Network

    NÍVEL SUPERIOR DA CARREIRA DE PESQUISA EM CIÊNCIA E TECNOLOGIA O DIRETOR DO INSTITUTO NACIONAL DE do Ministério da Ciência, Tecnologia e Inovação - MCTI, publicada no Diário Oficial da União de 30 de Pesquisa em Ciência e Tecnologia, de que trata a Lei nº 8.691, de 28 de julho de 1993, publicada no Diário

  2. REGIMENTO DO CURSO DE PS-GRADUAO EM ENGENHARIA E TECNOLOGIA ESPACIAIS

    E-print Network

    REGIMENTO DO CURSO DE PÓS-GRADUAÇÃO EM ENGENHARIA E TECNOLOGIA ESPACIAIS TÍTULO I DOS OBJETIVOS DO CURSO Art. 1o ­ O Curso de Pós-graduação em Engenharia e Tecnologia Espaciais (ETE) do INPE, com Tecnologia de Materiais e Sensores (CMS), doravante denominado Curso, objetiva formar e aperfeiçoar pessoal

  3. EMPREGO DE MISTURAS SOLO-ALCATRÃO DE MADEIRA DE EUCALIPTO EM ESTRADAS FLORESTAIS 1

    Microsoft Academic Search

    Dalila C. M. Fernandes; Carlos C. Machado; Dario C. Lima; Reginaldo S. Pereira

    6 RESUMO: Analisou-se o potencial de uso do alcatrão de madeira de eucalipto como aditivo químico para a estabilização de solos para estradas florestais. O programa de ensaios de laboratório englobou ensaios de caracterização e índice de suporte Califórnia (CBR), realizados em solos no estado natural e em misturas solo-alcatrão. Três amostras de solo representativas da cidade de Viçosa, estado

  4. Políticas de Apoio Governamental à Realização de Grandes Projetos de Investimento em Setores Geradores de Divisas

    Microsoft Academic Search

    Cézar Manoel de Medeiros

    2006-01-01

    Este trabalho fornece subsídios concretos para ações ativas do governo visando àestruturação de Parcerias em Planejamento e em Estratégias Empresariais (PPEEs) emsetores e empresas importantes para expandir e acelerar investimentos capazes deaumentar o volume e o valor adicionado das exportações, bem como para substituirseletivamente importações.É resultado de pesquisa realizada entre junho e novembro de 2004 com 20 gruposque reúnem 53

  5. Estudo comparativo entre estrelas centrais de nebulosas planetárias deficientes em hidrogênio

    NASA Astrophysics Data System (ADS)

    Marcolino, W. L. F.; de Araújo, F. X.

    2003-08-01

    Apresentamos neste trabalho o resultado de um estudo das principais características espectrais das estrelas centrais de nebulosas planetárias (ECNP) deficientes em hidrogênio. A origem e a evolução dessas estrelas ainda constitui um problema em aberto na evolução estelar. Geralmente esses objetos são divididos em [WCE], [WCL] e [WELS]. Os tipos [WCE] e [WCL] apresentam um espectro típico de uma estrela Wolf-Rayet carbonada de população I e as [WELS] apresentam linhas fracas de carbono e oxigênio em emissão. Existem evidências que apontam a seguinte sequência evolutiva : [WCL] = > [WCE] = > [WELS] = > PG 1159 (pré anã-branca). No entanto, tal cenário apresenta falhas como por exemplo a falta de ECNP entre os tipos [WCL] e [WCE]. Baseados em uma amostra de 24 objetos obtida no telescópio de 1.52m em La Silla, Chile (acordo ESO/ON), ao longo do ano 2000, apresentamos os resultados da comparação das larguras equivalentes de diversas linhas relevantes entre os tipos [WCL], [WCE] e [WELS]. Verificamos que nossos dados estão de acordo com a sequência evolutiva. Baseado nas linhas de C IV, conseguimos dividir pela primeira vez as [WELS] em dois grupos principais. Além disso, os dados reforçam a afirmação de que as [WCE] são as estrelas que possuem a maior temperatura entre as ECNP deficientes em hidrogênio. Discutimos ainda, a escassez de dados disponíveis na literatura e a necessidade da obtenção de parametros físicos para estes objetos.

  6. 9/7/2004 Penumadu, Prashant, and Frost. EM-2004 1 A VIRTUAL TRIAXIAL COMPRESSION

    E-print Network

    Prashant, Amit

    9/7/2004 Penumadu, Prashant, and Frost. EM-2004 1 A VIRTUAL TRIAXIAL COMPRESSION TEST SIMULATOR Dayakar Penumadu: Department of Civil and Environmental Engineering, University of Tennessee, Knoxville. #12;9/7/2004 Penumadu, Prashant, and Frost. EM-2004 2 Presentation Outline Concept of Virtual

  7. 9/7/2004 Prashant and Penumadu. EM-2004 1 EXPERIMENTAL ANALYSIS OF YIELDING AND

    E-print Network

    Prashant, Amit

    9/7/2004 Prashant and Penumadu. EM-2004 1 EXPERIMENTAL ANALYSIS OF YIELDING AND STRAIN LOCALIZATION OF MODERATELY OVERCONSOLIDATED KAOLIN CLAY Amit Prashant and Dayakar Penumadu Department of Civil are those of authors and do not necessarily reflect the views of NSF. #12;9/7/2004 Prashant and Penumadu. EM

  8. The simulated online EM algorithm for latent factor models

    NASA Astrophysics Data System (ADS)

    Rohde, D.; Cappé, O.; Dikmen, O.

    2012-10-01

    The estimation of latent factor models are treated in an integrated maximum likelihood context where one parameter is marginalized and another is estimated. An extension to the online Expectation Maximization (EM) algorithm is employed the simulated online Expectation Maximization algorithm. Both these algorithms apply to exponential family models, but the simulated version of the algorithm can make use of Monte Carlo simulation to compute the stochastic E-steps while maintaining the convergence properties of the original online EM algorithm. A class of important latent factor models are identified that can be expressed in complete data exponential family form, the algorithm is applied to one of these models Itakura-Saito Non-negative Matrix Factorisation. An additional parameter is introduced into this model and it is conjectured if this is set to a high value the posterior variance of the parameters is reduced and estimation becomes easier. Simulations are provided that support this conjecture, although online estimation for models with even a modest number of components continues to be hampered by the presence of local minima.

  9. Viewing Direction Estimation in Cryo-EM Using Synchronization*

    PubMed Central

    Shkolnisky, Yoel; Singer, Amit

    2013-01-01

    A central task in recovering the structure of a macromolecule from cryo-electron microscopy (cryo-EM) images is to determine a three-dimensional model of the macromolecule given many of its two-dimensional projection images. The direction from each image taken the images which was is unknown, and are small and extremely noisy. The goal is to determine the direction from which each image was taken and then to combine the images into a three-dimensional model of the molecule. We present an algorithm for determining the viewing direction of all cryo-EM images at once, which is robust to high levels of noise. The algorithm is based on formulating the problem as a synchronization problem; that is, we estimate the relative spatial configuration of pairs of images and then estimate a global assignment of orientations that maximizes the number of satisfied pairwise relations. Information about the spatial relation between pairs of images is extracted from common lines between triplets of images. These noisy pairwise relations are combined into a single consistent assignment of orientations by constructing a matrix whose entries encode the pairwise relations. This matrix is shown to have rank 3, and its nontrivial eigenspace is shown to reveal the projection orientation of each image. In particular, we show that the nontrivial eigenvectors encode the rotation matrix that corresponds to each image. PMID:24363820

  10. Chapter 19: HVAC Controls (DDC/EMS/BAS) Evaluation Protocol

    SciTech Connect

    Romberger, J.

    2014-11-01

    The HVAC Controls Evaluation Protocol is designed to address evaluation issues for direct digital controls/energy management systems/building automation systems (DDC/EMS/BAS) that are installed to control heating, ventilation, and air-conditioning (HVAC) equipment in commercial and institutional buildings. (This chapter refers to the DDC/EMS/BAS measure as HVAC controls.) This protocol may also be applicable to industrial facilities such as clean rooms and labs, which have either significant HVAC equipment or spaces requiring special environmental conditions. This protocol addresses only HVAC-related equipment and the energy savings estimation methods associated with installing such control systems as an energy efficiency measure. The affected equipment includes: Air-side equipment (air handlers, direct expansion systems, furnaces, other heating- and cooling-related devices, terminal air distribution equipment, and fans); Central plant equipment (chillers, cooling towers, boilers, and pumps). These controls may also operate or affect other end uses, such as lighting, domestic hot water, irrigation systems, and life safety systems such as fire alarms and other security systems. Considerable nonenergy benefits, such as maintenance scheduling, system component troubleshooting, equipment failure alarms, and increased equipment lifetime, may also be associated with these systems. When connected to building utility meters, these systems can also be valuable demand-limiting control tools. However, this protocol does not evaluate any of these additional capabilities and benefits.

  11. Overexpression of ?EmBP, a truncated dominant negative version of the wheat G-box binding protein EmBP-1, alters vegetative development in transgenic tobacco

    Microsoft Academic Search

    Nancy A. Eckardt; Lauren McHenry; Mark J. Guiltinan

    1998-01-01

    As a first step toward elucidating the in vivo function of plant bZIP proteins and their related G-box cis elements, we have introduced a dominant negative inhibitor of G-box-dependent transcriptional activation into tobacco plants by transforming them with a truncated EmBP-1 gene (?EmBP) containing the DNA binding and dimerization domains under the control of the CaMV 35S promoter. Five independent

  12. NEW ISOTOPES OF EMANATION AND FRANCIUM: ²²³Em, ²²⁴Em, AND ²²⁴Fr

    Microsoft Academic Search

    Bellido

    1961-01-01

    An examination of the products of the interaction of thorium with 230 ; Mev protons revealed evidence for the existence of the neutron-excess isotopes: ; Em²²³, Em²²⁴, and Fr²²⁴. The existence of these three new ; isotopes was confirmed by identification of their decay products: Ra²²³ and ; Ra²²⁴. (auth);

  13. Signaling of cell fate determination by the TPD1 small protein and EMS1 receptor kinase

    PubMed Central

    Jia, Gengxiang; Liu, Xiaodong; Owen, Heather A.; Zhao, Dazhong

    2008-01-01

    Sexual reproduction requires the specification of cells with distinct fates in plants and animals. The EMS1 (also known as EXS) leucine-rich repeat receptor-like kinase (LRR-RLK) and TPD1 small protein play key roles in regulating somatic and reproductive cell fate determination in Arabidopsis anthers. Here, we show that ectopic expression of TPD1 causes abnormal differentiation of somatic and reproductive cells in anthers. In addition, ectopic TPD1 activity requires functional EMS1. Yeast two-hybrid, pull-down, and coimmunoprecipitation analyses further demonstrate that TPD1 interacts with EMS1 in vitro and in vivo. Moreover, TPD1 induces EMS1 phosphorylation in planta. Thus, our results suggest that TPD1 serves as a ligand for the EMS1 receptor kinase to signal cell fate determination during plant sexual reproduction. PMID:18250314

  14. Phase 2 cost quality management assessment report for the Office of Technology Development (EM-50)

    SciTech Connect

    Not Available

    1994-08-01

    The Office of Environmental Management (EM) Head quarters (HQ) Cost Quality Management Assessment (CQMA) evaluated the practices of the Office of Technology Development (EM-50). The CQMA reviewed EM-50 management documents and reported results in the HQ CQMA Phase 1 report (March 1993). In this Assessment Phase, EM-50 practices were determined through interviews with staff members. The interviews were conducted from the end of September through early December 1993. EM-50 management documents (Phase 1) and practices (Phase 2) were compared to the Performance Objectives and Criteria (POCs) contained in the DOE/HQ Cost Quality Management Assessment Handbook. More detail on the CQMA process is provided in section 2. Interviewees are listed in appendix A. Documents reviewed during Phase 2 are listed in appendix B. Section 3 contains detailed observations, discussions, and recommendations. A summary of observations and recommendations is presented.

  15. Cryo-EM modeling by the molecular dynamics flexible fitting method

    PubMed Central

    Chan, Kwok-Yan; Trabuco, Leonardo G.; Schreiner, Eduard; Schulten, Klaus

    2012-01-01

    The increasing power and popularity of cryo-electron (cryo-EM) microscopy in structural biology brought about the development of so-called hybrid methods, which permit the interpretation of cryo-EM density maps beyond their nominal resolution in terms of atomic models. The Cryo-EM Modeling Challenge 2010 is the first community effort to bring together developers of hybrid methods as well as cryo-EM experimentalists. Participating in the challenge, the molecular dynamics flexible fitting (MDFF) method was applied to a number of cryo-EM density maps. The results are described here with special emphasis on the use of symmetry-based restraints to improve the quality of atomic models derived from density maps of symmetric complexes; on a comparison of the stereochemical quality of atomic models resulting from different hybrid methods; and on application of MDFF to electron crystallography data. PMID:22696404

  16. Observações no infravermelho médio de objetos estelares jovens em NGC 3576

    NASA Astrophysics Data System (ADS)

    Barbosa, C.; Damineli, A.; Blum, R.; Conti, P.

    2003-08-01

    Apresentamos os resultados de observações no infravermelho médio de candidatos a objetos estelares jovens e massivos em NGC 3576. As imagens de alta resolução foram obtidas no observatório Gemini Sul com o uso dos filtros em 10,8, 7,9, 9,8, 12,5 e 18,2 mm. Nossas imagens mostram a fonte IRS 1 resolvida em 4 objetos pela primeira vez em 10 mm. Para cada objeto obtivemos a distribuição espectral de energia de 1.2 até 18 mm, bem como a temperatura de cor, a distribuição espacial e a profundidade óptica em 9,8 mm da poeira circunstelar. Apresentamos uma estimativa das massas dos objetos estudados, baseados na luminosidade emitida no infravermelho médio, bem como um modelo para explicar as diferentes características observadas de cada objeto. Finalmente discutimos a possível localização da(s) fonte(s) de ionização de NGC 3576.

  17. Necessidade Urgente de Expanso de Programas de Preveno e Tratamento direcionados as Mulheres Trabalhadoras de Sexo em Moambique

    E-print Network

    Klein, Ophir

    Trabalhadoras de Sexo em Moçambique Em Moçambique, o HIV afecta desproporcionalmente as MTS. Mesmo assim, existe Sexo, Moçambique (IBBS-FSW) 2011-2012 em três grandes zonas urbanas do país: Maputo (incluindo Matola Executivo · As mulheres trabalhadoras do sexo (MTS) estão em maior risco de infecção pelo HIV e

  18. Efeito do silicato de potássio isoladamente ou em mistura com fungicida no controle da requeima da batateira

    Microsoft Academic Search

    Henrique da Silva Silveira Duarte; Laércio Zambolim; Fabrício Ávila Rodrigues; Jonas Alberto Rios

    2008-01-01

    Este trabalho teve como objetivo avaliar o efeito da aplicação foliar de silicato de potássio, isoladamente ou em mistura com diferentes doses do fungicida, no controle da requeima, causada por Phytophthora infestans, da batateira. O experimento foi conduzido em condições de campo utilizando-se o delineamento em blocos casualizados com 8 tratamentos e 4 repetições. A cultivar de batata usada foi

  19. A Gentle Tutorial of the EM Algorithm and its Application to Parameter Estimation for Gaussian Mixture and Hidden Markov Models

    Microsoft Academic Search

    Jeff A. Bilmes

    1997-01-01

    We describe the maximum-likelihood parameter estimation problem and how the Expectation- Maximization (EM) algorithm can be used for its solution. We first describe the abstract form of the EM algorithm as it is often given in the literature. We then develop the EM pa- rameter estimation procedure for two applications: 1) finding the parameters of a mixture of Gaussian densities,

  20. Encapsulamento e libera»c~ao de nanopart¶‡culas em magnetolipossomas recobertos com colesterol

    Microsoft Academic Search

    E. R. Cintra; A. F. Bakuzis; F. S. Ferreira; E. M. Lima; Faculdade de Farmacia

    2007-01-01

    A utiliza»c~ao de nanoestruturas magneticas no carreamento de drogase certamente uma das aplica»c~oes mais interessantes da Nanotecnologia. Neste caso temos uma aplica»c~ao de medicamentos local utilizando vetores espec¶‡flcos, como por exemplo, acoplando anticorpos a moleculas adsorvidas na superf¶‡cie de nanopart¶‡culas, ou ainda, utilizando gradiente de campo magnetico numa posi»c~ao espec¶‡flca do corpo do paciente. Esse tipo de estrategia conta com

  1. EM Properties of Magnetic Minerals at RADAR Frequencies

    NASA Technical Reports Server (NTRS)

    Stillman, D. E.; Olhoeft, G. R.

    2005-01-01

    Previous missions to Mars have revealed that Mars surface is magnetic at DC frequency. Does this highly magnetic surface layer attenuate RADAR energy as it does in certain locations on Earth? It has been suggested that the active magnetic mineral on Mars is titanomaghemite and/or titanomagnetite. When titanium is incorporated into a maghemite or magnetite crystal, the Curie temperature can be significantly reduced. Mars has a wide range of daily temperature fluctuations (303K - 143K), which could allow for daily passes through the Curie temperature. Hence, the global dust layer on Mars could experience widely varying magnetic properties as a function of temperature, more specifically being ferromagnetic at night and paramagnetic during the day. Measurements of EM properties of magnetic minerals were made versus frequency and temperature (300K- 180K). Magnetic minerals and Martian analog samples were gathered from a number of different locations on Earth.

  2. DOE-EM'S In-Situ Decommissioning Strategy

    SciTech Connect

    Negin, C.A.; Urland, C.S. [Chuck, Project Enhancement Corporation, Germantown, MD (United States); Szilagyi, A.P. [Andy, U.S. Department of Energy, Germantown, MD (United States)

    2008-07-01

    This paper addressed the current status of decommissioning projects within the Department of Energy (DOE) that have an end state of permanent entombment, referred to as in-situ decommissioning (ISD). The substance of a Department of Energy, Office of Environmental Management (DOE-EM) review of ISD and the development of a strategy are summarized. The strategy first recognizes ISD as a viable decommissioning end state; secondly addresses the integration of this approach within the external and internal regulatory regimes; subsequently identifies tools that need developing; and finally presents guidance for implementation. The overall conclusion is that ISD is a viable mode of decommissioning that can be conducted within the existing structure of rules and regulations. (author)

  3. EM modeling of RF drive in DTL tank 4

    SciTech Connect

    Kurennoy, Sergey S. [Los Alamos National Laboratory

    2012-06-19

    A 3-D MicroWave Studio model for the RF drive in the LANSCE DTL tank 4 has been built. Both eigensolver and time-domain modeling are used to evaluate maximal fields in the drive module and RF coupling. The LANSCE DTL tank 4 has recently been experiencing RF problems, which may or may not be related to its replaced RF coupler. This situation stimulated a request by Dan Rees to provide EM modeling of the RF drive in the DTL tank 4 (T4). Jim O'Hara provided a CAD model that was imported into the CST Microwave Studio (MWS) and after some modifications became a part of a simplified MWS model of the T4 RF drive. This technical note describes the model and presents simulation results.

  4. TrakEM2 Software for Neural Circuit Reconstruction

    PubMed Central

    Cardona, Albert; Saalfeld, Stephan; Schindelin, Johannes; Arganda-Carreras, Ignacio; Preibisch, Stephan; Longair, Mark; Tomancak, Pavel; Hartenstein, Volker; Douglas, Rodney J.

    2012-01-01

    A key challenge in neuroscience is the expeditious reconstruction of neuronal circuits. For model systems such as Drosophila and C. elegans, the limiting step is no longer the acquisition of imagery but the extraction of the circuit from images. For this purpose, we designed a software application, TrakEM2, that addresses the systematic reconstruction of neuronal circuits from large electron microscopical and optical image volumes. We address the challenges of image volume composition from individual, deformed images; of the reconstruction of neuronal arbors and annotation of synapses with fast manual and semi-automatic methods; and the management of large collections of both images and annotations. The output is a neural circuit of 3d arbors and synapses, encoded in NeuroML and other formats, ready for analysis. PMID:22723842

  5. Speech articulator measurements using low power EM-wave sensors

    SciTech Connect

    Holzrichter, J.F.; Burnett, G.C.; Ng, L.C. [Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, California 94551 (United States)] [Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, California 94551 (United States); Lea, W.A. [Speech Science Institute, P.O. Box 240428, Apple Valley, Minnesota 55124 (United States)] [Speech Science Institute, P.O. Box 240428, Apple Valley, Minnesota 55124 (United States)

    1998-01-01

    Very low power electromagnetic (EM) wave sensors are being used to measure speech articulator motions as speech is produced. Glottal tissue oscillations, jaw, tongue, soft palate, and other organs have been measured. Previously, microwave imaging (e.g., using radar sensors) appears not to have been considered for such monitoring. Glottal tissue movements detected by radar sensors correlate well with those obtained by established laboratory techniques, and have been used to estimate a voiced excitation function for speech processing applications. The noninvasive access, coupled with the small size, low power, and high resolution of these new sensors, permit promising research and development applications in speech production, communication disorders, speech recognition and related topics. {copyright} {ital 1998 Acoustical Society of America.}

  6. PREFACE: EmQM13: Emergent Quantum Mechanics 2013

    NASA Astrophysics Data System (ADS)

    2014-04-01

    These proceedings comprise the invited lectures of the second international symposium on Emergent Quantum Mechanics (EmQM13), which was held at the premises of the Austrian Academy of Sciences in Vienna, Austria, 3-6 October 2013. The symposium was held at the ''Theatersaal'' of the Academy of Sciences, and was devoted to the open exploration of emergent quantum mechanics, a possible ''deeper level theory'' that interconnects three fields of knowledge: emergence, the quantum, and information. Could there appear a revised image of physical reality from recognizing new links between emergence, the quantum, and information? Could a novel synthesis pave the way towards a 21st century, ''superclassical'' physics? The symposium provided a forum for discussing (i) important obstacles which need to be overcome as well as (ii) promising developments and research opportunities on the way towards emergent quantum mechanics. Contributions were invited that presented current advances in both standard as well as unconventional approaches to quantum mechanics. The EmQM13 symposium was co-organized by Gerhard Grössing (Austrian Institute for Nonlinear Studies (AINS), Vienna), and by Jan Walleczek (Fetzer Franklin Fund, USA, and Phenoscience Laboratories, Berlin). After a very successful first conference on the same topic in 2011, the new partnership between AINS and the Fetzer Franklin Fund in producing the EmQM13 symposium was able to further expand interest in the promise of emergent quantum mechanics. The symposium consisted of two parts, an opening evening addressing the general public, and the scientific program of the conference proper. The opening evening took place at the Great Ceremonial Hall (Grosser Festsaal) of the Austrian Academy of Sciences, and it presented talks and a panel discussion on ''The Future of Quantum Mechanics'' with three distinguished speakers: Stephen Adler (Princeton), Gerard 't Hooft (Utrecht) and Masanao Ozawa (Nagoya). The articles contained in these proceedings represent the talks of the invited speakers as written immediately after the symposium. The volume starts with a contribution by organizers Jan Walleczek and Gerhard Grössing, essentially explaining why emergent quantum mechanics, and other deterministic approaches to quantum theory, must be considered viable approaches in quantum foundations today. This is followed by the exposition of Stephen Adler's talk who introduced to a general audience key questions at the current frontiers of quantum mechanics during the opening evening (with the contents of his conference talk appearing elsewhere). The conference proceedings then continues with the presentations as given in their chronological order i.e. starting with the opening talk of the scientific program by Gerard 't Hooft. While the page number was restricted for all invited speakers, the paper by Jeff Tollaksen was given more space, as his invited collaborator Yakir Aharonov was unable to deliver a separate talk, in order to represent both contributions in one paper. Note that the talks of all speakers, including the talks of those who could not be represented in this volume (M. Arndt, B. Braverman, C. Brukner, S. Colin, Y. Couder, B. Poirier, A. Steinberg, G. Weihs and H. Wiseman) are freely available on the conference website as video presentations (http://www.emqm13.org). The organizers wish to express their gratitude to Siegfried Fussy and Herbert Schwabl from AINS for the organizational support. The organizers also wish to thank Bruce Fetzer, President and CEO, John E. Fetzer Memorial Trust, and the Members of the Board of Trustees, for their strong support and for funding this symposium. We also wish to thank the Austrian Academy of Sciences for allowing the symposium to be held on their premises, and Anton Zeilinger, President of the Austrian Academy of Sciences, for his welcome address. The expertise of the Members of the Scientific Advisory Board of the EmQM13 symposium, Ana Maria Cetto (Mexico), Lajos Diósi (Budapest), Maurice de Gosson (Vienna), Edward Nelson (Princeton), Theo Ni

  7. Cryo-EM model validation using independent map reconstructions

    PubMed Central

    DiMaio, Frank; Zhang, Junjie; Chiu, Wah; Baker, David

    2013-01-01

    An increasing number of cryo-electron microscopy (cryo-EM) density maps are being generated with suitable resolution to trace the protein backbone and guide sidechain placement. Generating and evaluating atomic models based on such maps would be greatly facilitated by independent validation metrics for assessing the fit of the models to the data. We describe such a metric based on the fit of atomic models with independent test maps from single particle reconstructions not used in model refinement. The metric provides a means to determine the proper balance between the fit to the density and model energy and stereochemistry during refinement, and is likely to be useful in determining values of model building and refinement metaparameters quite generally. PMID:23592445

  8. High-dimensional cluster analysis with the masked EM algorithm.

    PubMed

    Kadir, Shabnam N; Goodman, Dan F M; Harris, Kenneth D

    2014-11-01

    Cluster analysis faces two problems in high dimensions: the "curse of dimensionality" that can lead to overfitting and poor generalization performance and the sheer time taken for conventional algorithms to process large amounts of high-dimensional data. We describe a solution to these problems, designed for the application of spike sorting for next-generation, high-channel-count neural probes. In this problem, only a small subset of features provides information about the cluster membership of any one data vector, but this informative feature subset is not the same for all data points, rendering classical feature selection ineffective. We introduce a "masked EM" algorithm that allows accurate and time-efficient clustering of up to millions of points in thousands of dimensions. We demonstrate its applicability to synthetic data and to real-world high-channel-count spike sorting data. PMID:25149694

  9. Making connections. Voice and data solutions for EMS.

    PubMed

    Careless, James; Erich, John

    2008-08-01

    Communications used to be so simple-1) grab the radio, 2) push and talk. Now we're besieged by a confusing assortment of technology and terms-wideband, broadband, VoIP, RoIP, ect.- and a constand thrumming imperative to achieve and improve and perfect some mystical state of full interoperability. Frankly, it can all be a bit much. With this supplement, we hope to clarify you options. We examine the importance of broadband for EMS, with its potential for larger data "pipes" between the hospital and the field; advances in the promising technologies of Voice over IP and Radio over IP; and how some systems are improving their interconnectedness and resulting operations. The jargon can be overwhelming, but the ideas are worth understanding. PMID:18814746

  10. High-dimensional cluster analysis with the Masked EM Algorithm

    PubMed Central

    Kadir, Shabnam N.; Goodman, Dan F. M.; Harris, Kenneth D.

    2014-01-01

    Cluster analysis faces two problems in high dimensions: first, the “curse of dimensionality” that can lead to overfitting and poor generalization performance; and second, the sheer time taken for conventional algorithms to process large amounts of high-dimensional data. We describe a solution to these problems, designed for the application of “spike sorting” for next-generation high channel-count neural probes. In this problem, only a small subset of features provide information about the cluster member-ship of any one data vector, but this informative feature subset is not the same for all data points, rendering classical feature selection ineffective. We introduce a “Masked EM” algorithm that allows accurate and time-efficient clustering of up to millions of points in thousands of dimensions. We demonstrate its applicability to synthetic data, and to real-world high-channel-count spike sorting data. PMID:25149694

  11. DOE-EM-45 PACKAGING OPERATIONS AND MAINTENANCE COURSE

    SciTech Connect

    Watkins, R.; England, J.

    2010-05-28

    Savannah River National Laboratory - Savannah River Packaging Technology (SRNL-SRPT) delivered the inaugural offering of the Packaging Operations and Maintenance Course for DOE-EM-45's Packaging Certification Program (PCP) at the University of South Carolina Aiken on September 1 and 2, 2009. Twenty-nine students registered, attended, and completed this training. The DOE-EM-45 Packaging Certification Program (PCP) sponsored the presentation of a new training course, Packaging Maintenance and Operations, on September 1-2, 2009 at the University of South Carolina Aiken (USC-Aiken) campus in Aiken, SC. The premier offering of the course was developed and presented by the Savannah River National Laboratory, and attended by twenty-nine students across the DOE, NNSA and private industry. This training informed package users of the requirements associated with handling shipping containers at a facility (user) level and provided a basic overview of the requirements typically outlined in Safety Analysis Report for Packaging (SARP) Chapters 1, 7, and 8. The course taught packaging personnel about the regulatory nature of SARPs to help reduce associated and often costly packaging errors. Some of the topics covered were package contents, loading, unloading, storage, torque requirements, maintaining records, how to handle abnormal conditions, lessons learned, leakage testing (including demonstration), and replacement parts. The target audience for this course was facility operations personnel, facility maintenance personnel, and field quality assurance personnel who are directly involved in the handling of shipping containers. The training also aimed at writers of SARP Chapters 1, 7, and 8, package designers, and anyone else involved in radioactive material packaging and transportation safety. Student feedback and critiques of the training were very positive. SRNL will offer the course again at USC Aiken in September 2010.

  12. DOE-EM privatization and the 2006 Plan: Principles for procurement policies and risk management

    SciTech Connect

    Bjornstad, D.J.; Jones, D.W.; Duemmer, C.L.

    1997-08-01

    The Department of Energy`s Office of Environmental Remediation and Waste Management (EM) has recently set in place programs to restructure the strategic planning mechanism that will drive its clean-up schedule, The 2006 Plan, and to create a new set of business relationships with private contractors that will reduce costs--privatization. Taken together, the 2006 Plan and privatization will challenge EM to create new business practices to recast its risk management policies to support these initiatives while ensuring that its responsibilities toward the environment, human health, and worker safety (ES and H) are maintained. This paper argues that the 2006 Plan has transformed EM`s traditional, bottoms-up approach based on technical dictates to a top-down approach based on management goals--a transformation from an engineering problem to an economic problem. The 2006 Plan evolved from EM`s Ten-Year Plan, and seeks to convert the largely open-ended planning approach previously undertaken by EM to a plan bounded by time and dollars. The plan emphasizes making tradeoffs and choosing activities that deliver the most clean-up for the dollar. It also recognizes that each major player--stakeholders, DOE, OMB and Congress--has distinct interests that must be resolved if the process is to succeed. This, in turn, has created the need for a corresponding transformation in risk management practices from compliance-driven to benefit/cost-driven.

  13. UNIVERSIDADE DE BRASLIA PROGRAMA DE RESIDNCIA MDICO VETERINRIA EM PATOLOGICA CLNICA

    E-print Network

    Maier, Rudolf Richard

    Veterinária em Patologia Clínica Veterinária, em conformidade com as exigências do Regulamento deste programa número de vagas oferecidas consta abaixo: Patologia Clínica Veterinária (R1): 03 (três). 3. DA INSCRI��O Programa de Residência Médica Veterinária em Patologia Clínica Veterinária, para o Primeiro Período Letivo

  14. Effects of caffeine or EDTA post-treatment on EMS mutagenesis in soybean

    Microsoft Academic Search

    Zhu Baoge; Gu Aiqiu; Deng Xiangdong; Deng Yuxuan; Lu Zixian

    1995-01-01

    Seeds of soybean cultivar LD4 were mutagenically treated with EMS (0.3, 0.5, 0.6, 0.9, 0.5 and 1.8%) for 3 h only or plus caffeine (50 mM) or EDTA (1 mM) post-treatment for 5 h. The experimental results indicated that: (1) of the different concentrations of EMS treatment, the M2 mutation frequency induced with 0.6% EMS was the highest (9.7%). When

  15. EM Wake-Sleep Shiro.Ikeda@brain.riken.go.jp

    E-print Network

    Ikeda, Shiro

    ­EM Wake-Sleep ­ 21 2-1 Shiro.Ikeda@brain.riken.go.jp 1 (Latent Variable) 2 2.1 -5 -2.5 0 2.5 5 x+1), p(x; )) t+1 6 #12;3.3 Wake-Sleep EM G. Hinton EM Wake-Sleep [6] Helmholtz Helmholtz Helmholtz Helmholtz 6 M D q(y|x; ) p(x, y; ) 2 Wake-Sleep t+1 D M KL(q ,p )KL(p ,q ) t+1 t () ()() () t 7: Wake

  16. BENEFÍCIOS DO USO DE BANDEJAS DE AÇO INOXIDÁVEL NA QUALIDADE MICROBIOLÓGICA DE SARDINHAS COMERCIALIZADAS EM FEIRA-LIVRE DE SÃO PAULO

    Microsoft Academic Search

    Daniela Strauss; Thuler Vargas; Késia Diego Quintaes

    Resumo Sardinhas comercializadas em feira-livre de São Paulo foram avaliadas quanto à adequação aos padrões microbiológicos da legislação brasileira (ANVISA) antes e depois da exposição em bandejas de plástico e aço inoxidável (inox - 304). Foi verificada a interferência do material da bandeja na contaminação do produto. Amostras em triplicata dos estoques do gelo e da sardinha foram coletadas em

  17. Investigating the source of contaminated plumes downstream of the Alborz Sharghi coal washing plant using EM34 conductivity data, VLF-EM and DC-resistivity geophysical methods

    NASA Astrophysics Data System (ADS)

    Shiraz, Farzin Amirkhani; Ardejani, Faramarz Doulati; Moradzadeh, Ali; Arab-Amiri, Ali Reza

    2013-01-01

    Coal washing factories may create serious environmental problems due to pyrite oxidation and acid mine drainage generation from coal waste piles on nearby land. Infiltration of pyrite oxidation products through the porous materials of the coal waste pile by rainwater cause changes in the conductivity of underground materials and groundwater downstream of the pile. Electromagnetic and electrical methods are effective for investigation and monitoring of the contaminated plumes caused by coal waste piles and tailings impoundments. In order to investigate the environmental impact from a coal waste pile at the Alborz Sharghi coal washing plant, an EM34 ground conductivity meter was used on seven parallel lines in an E-W direction, downstream of the waste pile. Two-dimensional resistivity models obtained by the inversion of EM34 conductivity data identified conductive leachate plumes. In addition, quasi-3D inversion of EM34 data has confirmed the decreasing resistivity at depth due to the contaminated plumes. Comparison between EM34, VLF and DC-resistivity datasets, which were acquired for similar survey lines, agree well in identifying changes in the resistivity trend. The EM34 and DC-resistivity sections have greater similarity and better smoothness rather than those of the VLF model. Two-dimensional inversion models of these methods have shown some contaminated plumes with low resistivity.

  18. Governo apresenta reforma da rede do Superior em Maro sem contributo dos reitores

    E-print Network

    Instituto de Sistemas e Robotica

    Governo apresenta reforma da rede do Superior em Março sem contributo dos reitores O Ministério da a racionalização da rede do Superior que vai passar pela cria- ção de consórcios entre universida- des e

  19. Analysis of the electrochemistry of hemes with Ems spanning 800 mV

    PubMed Central

    Zheng, Zhong; Gunner, M. R.

    2009-01-01

    The free energy of heme reduction in different proteins is found to vary over more than 18 kcal/mol. It is a challenge to determine how proteins manage to achieve this enormous range of Ems with a single type of redox cofactor. Proteins containing 141 unique hemes of a-, b-, and c-type, with bis-His, His-Met, and aquo-His ligation were calculated using Multi-Conformation Continuum Electrostatics (MCCE). The experimental Ems range over 800 mV from ?350 mV in cytochrome c3 to 450 mV in cytochrome c peroxidase (vs. SHE). The quantitative analysis of the factors that modulate heme electrochemistry includes the interactions of the heme with its ligands, the solvent, the protein backbone, and sidechains. MCCE calculated Ems are in good agreement with measured values. Using no free parameters the slope of the line comparing calculated and experimental Ems is 0.73 (R2 = 0.90), showing the method accounts for 73% of the observed Em range. Adding a +160 mV correction to the His-Met c-type hemes yields a slope of 0.97 (R2 = 0.93). With the correction 65% of the hemes have an absolute error smaller than 60 mV and 92% are within 120 mV. The overview of heme proteins with known structures and Ems shows both the lowest and highest potential hemes are c-type, whereas the b-type hemes are found in the middle Em range. In solution, bis-His ligation lowers the Em by ?205 mV relative to hemes with His-Met ligands. The bis-His, aquo-His, and His-Met ligated b-type hemes all cluster about Ems which are ?200 mV more positive in protein than in water. In contrast, the low potential bis-His c-type hemes are shifted little from in solution, whereas the high potential His-Met c-type hemes are raised by ?300 mV from solution. The analysis shows that no single type of interaction can be identified as the most important in setting heme electrochemistry in proteins. For example, the loss of solvation (reaction field) energy, which raises the Em, has been suggested to be a major factor in tuning in situ Ems. However, the calculated solvation energy vs. experimental Em shows a slope of 0.2 and R2 of 0.5 thus correlates weakly with Ems. All other individual interactions show even less correlation with Em. However the sum of these terms does reproduce the range of observed Ems. Therefore, different proteins use different aspects of their structures to modulate the in situ heme electrochemistry. This study also shows that the calculated Ems are relatively insensitive to different heme partial charges and to the protein dielectric constant used in the simulation. PMID:19003997

  20. Multibeam Swath Bathymetry The Kongsberg Simrad EM-3000 Multibeam system is a high resolution echo

    E-print Network

    Wright, Dawn Jeannine

    Multibeam Swath Bathymetry The Kongsberg Simrad EM-3000 Multibeam system is a high resolution echo sounder which measures depth accurately to within several centimeters when post- processed. It not only

  1. UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL PROGRAMA DE PSGRADUAO EM MICROELETRNICA

    E-print Network

    dos Santos, C.A.

    Lubaszewski) (II) MIC56 SÍNTESE E PROCESSO EM NANOTECNOLOGIA (Prof. Daniel Baptista) (IF) MIC01 FISICA NANOTECNOLOGIA (Prof. Daniel Baptista) (IF) 15:30 MIC01 FISICA DE DISPOSITIVOS SEMICONDUTORES (Prof

  2. Performance Prediction and Analysis of BOINC Projects: An Empirical Study with EmBOINC

    E-print Network

    Estrada, Trilce; Taufer, Michela; Anderson, David P.

    2009-01-01

    Number of jobs Performance Prediction and Analysis of BOINCjob), execution Traces Fig. 3 Statistical host modeling Performance Prediction and Analysisand Analysis of BOINC Projects Table 3 Total throughput values in WCG and EmBOINC simulations Job

  3. 7. PHOTOCOPY, ELEVATIONS FOR E.M. BARRACKS, N.C.O. AND OFFICERS QUARTERS. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. PHOTOCOPY, ELEVATIONS FOR E.M. BARRACKS, N.C.O. AND OFFICERS QUARTERS. - NIKE Missile Base SL-40, Barracks No. 1, North end of base, southest of Basketball Court & northwest of Barracks No. 2, Hecker, Monroe County, IL

  4. Cryo-EM of macromolecular assemblies at near-atomic resolution.

    PubMed

    Baker, Matthew L; Zhang, Junjie; Ludtke, Steven J; Chiu, Wah

    2010-09-01

    With single-particle electron cryomicroscopy (cryo-EM), it is possible to visualize large, macromolecular assemblies in near-native states. Although subnanometer resolutions have been routinely achieved for many specimens, state of the art cryo-EM has pushed to near-atomic (3.3-4.6 Å) resolutions. At these resolutions, it is now possible to construct reliable atomic models directly from the cryo-EM density map. In this study, we describe our recently developed protocols for performing the three-dimensional reconstruction and modeling of Mm-cpn, a group II chaperonin, determined to 4.3 Å resolution. This protocol, utilizing the software tools EMAN, Gorgon and Coot, can be adapted for use with nearly all specimens imaged with cryo-EM that target beyond 5 Å resolution. Additionally, the feature recognition and computational modeling tools can be applied to any near-atomic resolution density maps, including those from X-ray crystallography. PMID:20885381

  5. EM2006K-33 revised Identification of forces shaping the commensal Escherichia coli

    E-print Network

    1 EM2006K-33 revised Identification of forces shaping the commensal Escherichia coli genetic title: Commensal Escherichia coli ecological structure Key words: Escherichia coli, commensal, animal forces shaping the Escherichia coli intraspecies ecological structure, we have characterized in terms

  6. Instituto Nacional de Pesquisas Espaciais Exame para o curso de ps-graduao em Astrofsica

    E-print Network

    for Extraterrestrial Intelligence), afirmava que o grande radiotelescópio de Arecibo, em Porto Rico, "pode detectar um magnético? b) A que aceleração ele é submetido? #12;6. Frank Drake, um dos criadores do projeto SETI (Search

  7. Programao 1 Encontro para Estudos em Polticas e Prticas de Educao Ambiental

    E-print Network

    Souza, Max O.

    Programação 1º Encontro para Estudos em Políticas e Práticas de Educação Ambiental 14:00 às 14:20 - A unidade curricular Políticas de Educação Ambiental no contexto da proposta interdisciplinar do Projeto Pedagógico do Curso de Bacharelado em Ciência Ambiental do Instituto de Geociências - Profa. Patricia Almeida

  8. IDENTIFICAC ~AO E RASTREAMENTO EM TEMPO REAL DE M ULTIPLOS AGENTES AUT ^ONOMOS

    E-print Network

    Zhang, Richard "Hao"

    - treamento em tempo real de objetos durante o jogo. Diversos experimentos reais s~ao realizados para~ao, v´arios experimentos t^em sido realizados visando `a construc¸~ao de um time completo de rob^os com^o deve carregar uma bola de ping-pong colorida que ´e usada como o uniforme ou camiseta do time. O campo

  9. The Soils and Groundwater – EM-20 S&T Roadmap Quality Assurance Project Plan

    SciTech Connect

    Fix, N. J.

    2008-02-11

    The Soils and Groundwater – EM-20 Science and Technology Roadmap Project is a U.S. Department of Energy, Office of Environmental Management-funded initiative designed to develop new methods, strategies and technology for characterizing, modeling, remediating, and monitoring soils and groundwater contaminated with metals, radionuclides, and chlorinated organics. This Quality Assurance Project Plan provides the quality assurance requirements and processes that will be followed by EM-20 Roadmap Project staff.

  10. I like how this sounds: Am-Dm-G-C-F-Bm-Em-E

    E-print Network

    Reiners, Peter W.

    I like how this sounds: Am-Dm-G-C-F-Bm-Em-E Am Dm G At first I was afraid, I was petrified I kept thinkin' I could never live C F Bm without you by my side But then I spent so many nights just thinking how you've Em E done me wrong And I grew strong, I learned how to get along... Am Dm G And so you

  11. Very Fast EM-Based Mixture Model Clustering Using Multiresolution Kd-Trees

    Microsoft Academic Search

    Andrew W. Moore

    1998-01-01

    Clustering is important in many fields including manufacturing, biology,finance, and astronomy. Mixture models are a popular approachdue to their statistical foundations, and EM is a very popular methodfor finding mixture models. EM, however, requires many accesses ofthe data, and thus has been dismissed as impractical (e.g. (Zhang, Ramakrishnan,& Livny, 1996)) for data mining of enormous datasets.We present a new algorithm,

  12. Self-assembled monolayers improve protein distribution on holey carbon cryo-EM supports

    PubMed Central

    Meyerson, Joel R.; Rao, Prashant; Kumar, Janesh; Chittori, Sagar; Banerjee, Soojay; Pierson, Jason; Mayer, Mark L.; Subramaniam, Sriram

    2014-01-01

    Poor partitioning of macromolecules into the holes of holey carbon support grids frequently limits structural determination by single particle cryo-electron microscopy (cryo-EM). Here, we present a method to deposit, on gold-coated carbon grids, a self-assembled monolayer whose surface properties can be controlled by chemical modification. We demonstrate the utility of this approach to drive partitioning of ionotropic glutamate receptors into the holes, thereby enabling 3D structural analysis using cryo-EM methods. PMID:25403871

  13. UM MODELO PARA RECOMENDAÇÃO DE ARTIGOS ACADÊMICOS BASEADO EM FILTRAGEM COLABORATIVA APLICADO À AMBIENTES MÓVEIS

    Microsoft Academic Search

    Sílvio César Cazella

    Resumo. Sistemas de Recomendação (SR) são hoje amplamente utilizados, principalmente na área de e-commerce como, por exemplo, Amazon.com e Submarino.com. Neste trabalho, propõe-se a utilização destes sistemas na educação, especificamente para a recomendação de conteúdo em dispositivos móveis. A vantagem de se utilizar sistemas de recomendação em dispositivos móveis está na facilidade da entrega da recomendação aos usuários. Com base

  14. Fast, simultaneous and robust VLF-EM data denoising and reconstruction via multivariate empirical mode decomposition

    NASA Astrophysics Data System (ADS)

    Sungkono; Bahri, Ayi S.; Warnana, Dwa D.; Monteiro Santos, Fernando A.; Santosa, Bagus J.

    2014-06-01

    The measurement of Very Low Frequency Electromagnetic (VLF-EM) is important in many different applications, i.e, environmental, archeological, geotechnical studies, etc. In recent years, improving and enhancing VLF-EM data containing complex numbers (bivariate) was presented by several authors in order to produce reliable models, generally using univariate empirical mode decomposition (EMD). Applying univariate EMD separately on each data is problematic. This results in a different number of misaligned Intrinsic Mode Functions (IMFs) which can complicate the selection of some IMFs for denoising process. Thus, a filtering method based on the multivariate empirical mode decomposition (MEMD) approach to decompose simultaneously bivariate data is proposed. In this paper we address two issues by employing the recently introduced noise assisted MEMD (N-A MEMD) for improving bivariate VLF-EM data. Firstly, the N-A MEMD to decompose bivariate measurement of the VLF-EM data into IMFs and a residue is defined as VLF-EM signal or unwanted noise. Secondly, the proposed method is used to enhance VLF-EM data and to reject unwanted noise. Finally, the proposed method is applied to a synthetic data with two added sinusoids. To demonstrate the robustness of the N-A MEMD method, the method was tested on added-noise synthetic data sets and the results were compared to the Ensemble EMD (EEMD) and Bivariate EMD (BEMD). The N-A MEMD gave more robust and accurate results than the EEMD and BEMD methods and the method required less CPU time to obtain the IMFs compared to EEMD. The method was also tested on several field data sets. The results indicate that the filtered VLF-EM data based on the N-A MEMD make the data easier to interpret and to be analyzed further. In addition, the 2D resistivity profile estimated from the inversion of filtered VLF-EM data results was appropriate to the geological condition.

  15. Tide-driven fluid mud transport in the Ems estuary

    NASA Astrophysics Data System (ADS)

    Becker, Marius; Maushake, Christian; Winter, Christian

    2014-05-01

    The Ems estuary, located at the border between The Netherlands and Germany, experienced a significant change of the hydrodynamic regime during the past decades, as a result of extensive river engineering. With the net sediment transport now being flood-oriented, suspended sediment concentrations have increased dramatically, inducing siltation and formation of fluid mud layers, which, in turn, influence hydraulic flow properties, such as turbulence and the apparent bed roughness. Here, the process-based understanding of fluid mud is essential to model and predict mud accumulation, not only regarding the anthropogenic impact, but also in view of the expected changes of environmental boundary conditions, i.e., sea level rise. In the recent past, substantial progress has been made concerning the understanding of estuarine circulation and influence of tidal asymmetry on upstream sediment accumulation. While associated sediment transport formulations have been implemented in the framework of numerical modelling systems, in-situ data of fluid mud are scarce. This study presents results on tide-driven fluid mud dynamics, measured during four tidal cycles aside the navigation channel in the Ems estuary. Lutoclines, i.e., strong vertical density gradients, were detected by sediment echo sounder (SES). Acoustic Doppler current profiles (ADCP) of different acoustic frequencies were used to determine hydrodynamic parameters and the vertical distribution of suspended sediment concentrations in the upper part of the water column. These continuous profiling measurements were complemented by CTD, ADV, and OBS casts. SES and ADCP profiles show cycles of fluid mud entrainment during accelerating flow, and subsequent settling, and the reformation of a lutocline during decelerating flow and slack water. Significant differences are revealed between flood and ebb phase. Highest entrainment rates are measured at the beginning of the flood phase, associated with strong current shear and rapid vertical mixing, inducing the highest instantaneous suspended sediment flux measured during the tidal cycle. During decelerating flood currents a lutocline is again established at a certain distance above the consolidated river bed. During slack water after the flood phase the concentration gradient increases and the thickness of the fluid mud layer below is constant, also during a significant part of the ebb phase. As water depth decreases during ebb, entrainment occurs only at the upper part of the fluid mud layer. The suspended sediment flux is low compared to the flood phase. These observations are further elaborated using turbulence parameters obtained from ADV and ADCP, explaining the difference between ebb and flood concerning the vertical location of the maximum concentration gradient. This study is funded through DFG-Research Center / Excellence Cluster "The Ocean in the Earth System". The Senckenberg Institute and the Federal Waterways Engineering and Research Institute are acknowledged for technical support.

  16. Observações simultâneas no óptico e infravermelho próximo dos BL Lacs PKS 2005-489 e PKS 2155-304 em diversas escalas de tempo

    NASA Astrophysics Data System (ADS)

    Dominici, T. P.; Abraham, Z.; Galo, A. L.

    2003-08-01

    A existência de variações rápidas de brilho em alguns blazares é um fenômeno bem comprovado, mas até agora não sabemos ao certo quais são os mecanismos físicos envolvidos. A maior dificuldade é a ausência de observações multibanda simultâneas que poderiam fornecer vínculos aos modelos. Buscando colaborar com a discussão estudamos o comportamento de dois BL Lacs, PKS 2005-489 e PKS 2155-304, em relação à variabilidade em diversas escalas de tempo, de poucos minutos até vários meses, com observações simultâneas em seis bandas espectrais (óptico e infravermelho próximo). Para tanto dois telescópios do LNA foram utilizados em conjunto nas campanhas observacionais realizadas em 2001 e 2002, cujos resultados são apresentados aqui. As duas fontes apresentaram características bastante diferentes, inclusive em relação à existência de variabilidade nos índices espectrais. Particularmente, registramos a primeira detecção de variações em escalas de tempo da ordem de poucos minutos em PKS 2005-489, com evidências da presença de um atraso entre as curvas de luz nas bandas V e R e a variação em R ocorrendo antes (o contrário do esperado no modelo de shock-in-jet). Em PKS 2155-304 detectamos pela primeira vez variabilidade em escalas de tempo de poucos minutos no infravermelho em um AGN. As observações indicam que as variações de brilho em blazares são o resultado da ação de mais de um fenômeno, especialmente em escalas de tempo muito curtas. Alguns cenários físicos são sugeridos para explicar os resultados observacionais.

  17. New Developments in the Technology Readiness Assessment Process in US DOE-EM - 13247

    SciTech Connect

    Krahn, Steven [Department of Civil and Environmental Engineering, Vanderbilt University, Nashville, TN, 37235 (United States)] [Department of Civil and Environmental Engineering, Vanderbilt University, Nashville, TN, 37235 (United States); Sutter, Herbert [Consultant, 910 Laurel Green Dr., North Canton, OH, 44720 (United States)] [Consultant, 910 Laurel Green Dr., North Canton, OH, 44720 (United States); Johnson, Hoyt [DOE-EM, 1000 Independence Ave., Washington, DC, 20585 (United States)] [DOE-EM, 1000 Independence Ave., Washington, DC, 20585 (United States)

    2013-07-01

    A Technology Readiness Assessment (TRA) is a systematic, metric-based process and accompanying report that evaluates the maturity of the technologies used in systems; it is designed to measure technology maturity using the Technology Readiness Level (TRL) scale pioneered by the National Aeronautics and Space Administration (NASA) in the 1980's. More recently, DoD has adopted and provided systematic guidance for performing TRAs and determining TRLs. In 2007 the GAO recommended that the DOE adopt the NASA/DoD methodology for evaluating technology maturity. Earlier, in 2006-2007, DOE-EM had conducted pilot TRAs on a number of projects at Hanford and Savannah River. In March 2008, DOE-EM issued a process guide, which established TRAs as an integral part of DOE-EM's Project Management Critical Decision Process. Since the development of its detailed TRA guidance in 2008, DOE-EM has continued to accumulate experience in the conduct of TRAs and the process for evaluating technology maturity. DOE has developed guidance on TRAs applicable department-wide. DOE-EM's experience with the TRA process, the evaluations that led to recently developed proposed revisions to the DOE-EM TRA/TMP Guide; the content of the proposed changes that incorporate the above lessons learned and insights are described. (authors)

  18. Method for estimating dynamic EM tracking accuracy of surgical navigation tools

    NASA Astrophysics Data System (ADS)

    Nafis, Christopher; Jensen, Vern; Beauregard, Lee; Anderson, Peter

    2006-03-01

    Optical tracking systems have been used for several years in image guided medical procedures. Vendors often state static accuracies of a single retro-reflective sphere or LED. Expensive coordinate measurement machines (CMM) are used to validate the positional accuracy over the specified working volume. Users are interested in the dynamic accuracy of their tools. The configuration of individual sensors into a unique tool, the calibration of the tool tip, and the motion of the tool contribute additional errors. Electromagnetic (EM) tracking systems are considered an enabling technology for many image guided procedures because they are not limited by line-of-sight restrictions, take minimum space in the operating room, and the sensors can be very small. It is often difficult to quantify the accuracy of EM trackers because they can be affected by field distortion from certain metal objects. Many high-accuracy measurement devices can affect the EM measurements being validated. EM Tracker accuracy tends to vary over the working volume and orientation of the sensors. We present several simple methods for estimating the dynamic accuracy of EM tracked tools. We discuss the characteristics of the EM Tracker used in the GE Healthcare family of surgical navigation systems. Results for other tracking systems are included.

  19. Anisotropic 3D inversion of towed streamer EM data from the Troll West oil province (Invited)

    NASA Astrophysics Data System (ADS)

    Mattsson, J.; Midgley, J.; Zhdanov, M. S.; ENDO, M.

    2013-12-01

    Obviating the need for ocean bottom receivers, the towed streamer EM system enables CSEM data to be acquired simultaneously with seismic over very large areas in frontier and mature basins for higher production rates and more cost effective than conventional marine CSEM. The towed streamer EM data are currently processed and delivered as a spectrum of frequency-domain responses. We apply a 3D anisotropic inversion methodology for towed streamer EM data that includes a moving sensitivity domain. Our implementation is based on the 3D contraction integral equation method for computing the EM responses and Fréchet derivatives, and uses the re-weighted regularized conjugate gradient method for minimizing the objective functional with focusing regularization. We present an actual case study for the 3D anisotropic inversion of towed streamer EM data from the Troll West oil province in the North Sea, and demonstrate our ability to image the Troll West Oil and Gas Provinces. We conclude that 3D anisotropic inversion of the data from the current generation of towed streamer EM system can adequately recover both the vertical and horizontal resistivities in anisotropic hydrocarbon-bearing formations.

  20. BSSDATA - um programa otimizado para filtragem de dados em radioastronomia solar

    NASA Astrophysics Data System (ADS)

    Martinon, A. R. F.; Sawant, H. S.; Fernandes, F. C. R.; Stephany, S.; Preto, A. J.; Dobrowolski, K. M.

    2003-08-01

    A partir de 1998, entrou em operação regular no INPE, em São José dos Campos, o Brazilian Solar Spectroscope (BSS). O BSS é dedicado às observações de explosões solares decimétricas com alta resolução temporal e espectral, com a principal finalidade de investigar fenômenos associados com a liberação de energia dos "flares" solares. Entre os anos de 1999 e 2002, foram catalogadas, aproximadamente 340 explosões solares classificadas em 8 tipos distintos, de acordo com suas características morfológicas. Na análise detalhada de cada tipo, ou grupo, de explosões solares deve-se considerar a variação do fluxo do sol calmo ("background"), em função da freqüência e a variação temporal, além da complexidade das explosões e estruturas finas registradas superpostas ao fundo variável. Com o intuito de realizar tal análise foi desenvolvido o programa BSSData. Este programa, desenvolvido em linguagem C++, é constituído de várias ferramentas que auxiliam no tratamento e análise dos dados registrados pelo BSS. Neste trabalho iremos abordar as ferramentas referentes à filtragem do ruído de fundo. As rotinas do BSSData para filtragem de ruído foram testadas nos diversos grupos de explosões solares ("dots", "fibra", "lace", "patch", "spikes", "tipo III" e "zebra") alcançando um bom resultado na diminuição do ruído de fundo e obtendo, em conseqüência, dados onde o sinal torna-se mais homogêneo ressaltando as áreas onde existem explosões solares e tornando mais precisas as determinações dos parâmetros observacionais de cada explosão. Estes resultados serão apresentados e discutidos.

  1. EM modeling for GPIR using 3D FDTD modeling codes

    SciTech Connect

    Nelson, S.D.

    1994-10-01

    An analysis of the one-, two-, and three-dimensional electrical characteristics of structural cement and concrete is presented. This work connects experimental efforts in characterizing cement and concrete in the frequency and time domains with the Finite Difference Time Domain (FDTD) modeling efforts of these substances. These efforts include Electromagnetic (EM) modeling of simple lossless homogeneous materials with aggregate and targets and the modeling dispersive and lossy materials with aggregate and complex target geometries for Ground Penetrating Imaging Radar (GPIR). Two- and three-dimensional FDTD codes (developed at LLNL) where used for the modeling efforts. Purpose of the experimental and modeling efforts is to gain knowledge about the electrical properties of concrete typically used in the construction industry for bridges and other load bearing structures. The goal is to optimize the performance of a high-sample-rate impulse radar and data acquisition system and to design an antenna system to match the characteristics of this material. Results show agreement to within 2 dB of the amplitudes of the experimental and modeled data while the frequency peaks correlate to within 10% the differences being due to the unknown exact nature of the aggregate placement.

  2. XMM-{\\em Newton} Observations of Optically Selected SDSS Clusters

    E-print Network

    M. Plionis; S. Basilakos; I. Georgantopoulos; A. Georgakakis

    2004-10-22

    We explore the X-ray properties of a subset of the optically selected SDSS cluster sample of Goto et al. (2002), by analysing seven public XMM-{\\em Newton} pointings, with exposure times ranging from $\\sim$ 4 to 46 ksec. There are in total 17 SDSS clusters out of which only eight are detected at X-ray wavelengths with $\\rm f_{0.5-2keV}\\magcir 1.2 \\times 10^{-14}$ ergs cm$^{-2}$ s$^{-1}$. For the remaining 9 SDSS clusters we estimate their 3$\\sigma$ luminosity upper limits (corresponding to $L_x\\mincir 5\\times 10^{42}$ ergs/sec in the 0.5-2 keV band). This relatively low luminosity suggests that if real structures, these galaxy aggregations correspond to poor groups of galaxies. Using the SDSS photometric catalogue we also derive the cluster optical $r$-band luminosities. The resulting scaling relations ($L_{\\rm opt}-L_x$, $L_{\\rm opt}-T_x$) are consistent with those of other recent studies.

  3. If EM waves don't interfere, what causes interferograms?

    NASA Astrophysics Data System (ADS)

    Wellard, Stanley J.

    2012-10-01

    Photonics engineers involved in designing and operating Fourier transform spectrometers (FTS) often rely on Maxwell's wave equations and time-frequency (distance-wavenumber) Fourier theory as models to understand and predict the conversion of optical energy to electrical signals in their instruments. Dr. Chandrasekhar Roychoudhuri and his colleagues, at last year's conference, presented three significant concepts that might completely change the way we comprehend the interaction of light and matter and the way interference information is generated. The first concept is his non-interaction of waves (NIW) formulation, which puts in place an optical wave description that more accurately describe the properties of the finite time and spatial signals of an optical system. The second is a new description for the cosmic EM environment that recognizes that space is really filled with the ether of classical electromagnetics. The third concept is a new metaphysics or metaphotonics that compares the photon as a particle in a void against the photon as a wave in a medium to see which best explain the twelve different aspects of light. Dr. Henry Lindner presents a compelling case that photons are waves in a medium and particles (electrons, protons, atoms) are wave-structures embedded in the new ether. Discussion of the three new principles is intended to increase the curiosity of photonics engineers to investigate these changes in the nature of light and matter.

  4. The tidal asymmetries and residual flows in Ems Estuary

    NASA Astrophysics Data System (ADS)

    Pein, Johannes Ulrich; Stanev, Emil Vassilev; Zhang, Yinglong Joseph

    2014-12-01

    A 3D unstructured-grid numerical model of the Ems Estuary is presented. The simulated hydrodynamics are compared against tidal gauge data and observations from research cruises. A comparison with an idealized test reveals the capability of the model to reproduce the secondary circulation patterns known from theoretical results. The simulations prove to be accurate and realistic, confirming and extending findings from earlier observations and modeling studies. The basic characteristics of dominant physical processes in the estuary such as tidal amplification, tidal damping, overtide generation, baroclinicity and internal mixing asymmetry are quantified. The model demonstrates an overall dominance of the flood currents in most of the studied area. However, the hypsometric control in the vicinity of Dollart Bay reverses this asymmetry, with the ebb currents stronger than the flood ones. Small-scale bathymetric characteristics and baroclinicity result in a very complex interplay between dominant physical mechanisms in different parts of the tidal channels and over the tidal flats. Residual flow reveals a clear overturning circulation in some parts of the estuary which is related to a mixing asymmetry between flood and ebb currents. We demonstrate that while areas close to the tidal river exhibit overall similarity with density controlled estuarine conditions, in large areas of the outer estuary barotropic forcing and complex bathymetry together with the density distribution affect substantially the horizontal circulation.

  5. PET of Insulinoma using 18F-FBEM-EM3106B, a New GLP-1 Analog

    PubMed Central

    Gao, Haokao; Niu, Gang; Yang, Min; Quan, Qimeng; Ma, Ying; Murage, Eunice N.; Ahn, Jung-Mo; Kiesewetter, Dale O.; Chen, Xiaoyuan

    2011-01-01

    Derived from endocrine pancreatic beta cells, insulinomas express glucagon-like peptide-1 (GLP-1) receptor with high density and incidence. In this study, we labeled a novel GLP-1 analog, EM3106B, with 18F and performed PET imaging to visualize insulinoma tumors in an animal model. A GLP-1 analog that contains multiple lactam bridges, EM3106B, was labeled with 18F through a maleimide-based prosthetic group, N-2-(4-18F-fluorobenzamido) ethylmaleimide (18F-FBEM). The newly developed radiotracer was characterized by cell based receptor-binding assay, cell uptake and efflux assay. The stability in serum was evaluated by radio-HPLC analysis. In vivo PET imaging was performed in nude mice bearing subcutaneous INS-1 insulinoma tumors and MDA-MB-435 tumors of melanoma origin. Ex vivo biodistribution study was performed to confirm the PET imaging data. EM3106B showed high binding affinity (IC50 = 1.38 nM) and high cell uptake (5.25 ± 0.61% after 120 min incubation). 18F-FBEM conjugation of EM3106B resulted in high labeling yield (24.9 ± 2.4%) and high specific activity (>75 GBq/ ?mol at the end of bombardment). EM3106B specifically bound and was internalized by GLP-1R positive INS-1 cells. After intravenous injection of 3.7 MBq (100 ?Ci) of 18F-FBEM-EM3106B, the INS-1 tumors were clearly visible with high contrast in relation to the contralateral background on PET images, and tumor uptake of 18F-FBEM-EM3106B was determined to be 28.5 ± 4.7 and 25.4 ± 4.1 %ID/g at 60 and 120 min, respectively. 18F-FBEM-EM3106B showed low uptake in MB-MDA-435 tumors with low level of GLP-1R expression. Direct tissue sampling biodistribution experiment confirmed high tracer uptake in INS-1 tumors and receptor specificity in both INS-1 tumor and pancreas. In conclusion, 18F-FBEM-EM3106B exhibited GLP-1R-receptor-specific targeting properties in insulinomas. The favorable characteristics of 18F-FBEM-EM3106B, such as high specific activity and high tumor uptake, and high tumor to non-target uptake, demonstrate that it is a promising tracer for clinical insulinoma imaging. PMID:21800885

  6. Employee retention: applying hospital strategies to EMS. With increasing demand for and decreasing supply of EMTs and paramedics, retention strategies should be a priority for EMS organizations.

    PubMed

    Powers, Robert

    2007-10-01

    Retention strategies are a priority for EMS organizations. These strategies must be broad and varied to address the variety of reasons employees leave healthcare organizations. The value of creating these programs should manifest itself through increased employee satisfaction and an increased sense of belonging to the organization. PMID:17983102

  7. Rock 'Em, Sock 'Em!

    ERIC Educational Resources Information Center

    Waters, John K.

    2011-01-01

    K-12-level competitive robotics is growing in popularity around the country and worldwide. According to one of the leading organizers of these events, FIRST--For Inspiration and Recognition of Science and Technology--250,000 students from 56 countries take part in its competitions. FIRST Tech Challenge (FTC) is a yearly event the organization puts…

  8. Compositions of HIMU, EM1, and EM2 from global trends between radiogenic isotopes and major elements in ocean island basalts

    NASA Astrophysics Data System (ADS)

    Jackson, Matthew G.; Dasgupta, Rajdeep

    2008-11-01

    Sr and Pb isotopes exhibit global trends with the concentrations of major elements (SiO 2, TiO 2, FeO, Al 2O 3 and K 2O) and major elements ratios (CaO/Al 2O 3 and K 2O/TiO 2) in the shield-stage lavas from 18 oceanic hotspots (including Hawaii, Iceland, Galapagos, Cook-Australs, St. Helena, Cape Verde, Cameroon, Canary, Madeira, Comoros, Azores, Samoa, Society, Marquesas, Mascarene, Kerguelen, Pitcairn, and Selvagen). Based on the relationships between major elements and isotopes in ocean island basalts (OIBs), we find that the lavas derived from the mantle end members, HIMU (or high '?' = 238U/ 204Pb), EM1 (enriched mantle 1), EM2 (enriched mantle 2), and DMM (depleted MORB [mid-ocean ridge basalt] mantle) exhibit distinct major element characteristics: When compared to oceanic hotspots globally, the hotspots with a HIMU (radiogenic Pb-isotopes and low 87Sr/ 86Sr) component, such as St. Helena and Cook-Australs, exhibit high CaO/Al 2O 3, FeO T, and TiO 2 and low SiO 2 and Al 2O 3. EM1 (enriched mantle 1; intermediate 87Sr/ 86Sr and low 206Pb/ 204Pb; sampled by hotspots like Pitcairn and Kerguelen) and EM2 (enriched mantle 2; high 87Sr/ 86Sr and intermediate 206Pb/ 204Pb; sampled by hotspots like Samoa and Societies) exhibit higher K 2O concentrations and K 2O/TiO 2 weight ratios than HIMU lavas. EM1 lavas exhibit the lowest CaO/Al 2O 3 in the OIB dataset, and this sets EM1 apart from EM2. A plot of CaO/Al 2O 3 vs K 2O/TiO 2 perfectly resolves the four mantle end member lavas. Melting processes (pressure, temperature and degree of melting) fail to provide an explanation for the full spectrum of major element concentrations in OIBs. Such processes also fail to explain the correlations between major elements and radiogenic isotopes. Instead, a long, time integrated history of various parent-daughter elements appears to be coupled to major element and/or volatile heterogeneity in the mantle source. End member lava compositions are compared with experimental partial melt compositions to place constraints on the lithological characteristics of the mantle end members.

  9. Compositions of HIMU, EM1, and EM2 from Global Trends between Radiogenic Isotopes and Major Elements in Ocean Island Basalts

    NASA Astrophysics Data System (ADS)

    Jackson, M. G.; Dasgupta, R.

    2008-12-01

    Sr and Pb isotopes exhibit global trends with the concentrations of major elements (SiO2, TiO2, FeO, Al2O3 and K2O) and major elements ratios (CaO/Al2O3 and K2O/TiO2) in the shield-stage lavas from 18 oceanic hotspots (including Hawaii, Iceland, Galapagos, Cook-Australs, St. Helena, Cape Verde, Cameroon, Canary, Madeira, Comoros, Azores, Samoa, Society, Marquesas, Mascarene, Kerguelen, Pitcairn, and Selvagen). Based on the relationships between major elements and isotopes in ocean island basalts (OIBs), we find that the lavas derived from the mantle end members, HIMU (or high 'ì' = 238U/204Pb), EM1 (enriched mantle 1), EM2 (enriched mantle 2), and DMM (depleted MORB [mid-ocean ridge basalt] mantle) exhibit distinct major element characteristics: When compared to oceanic hotspots globally, the hotspots with a HIMU (radiogenic Pb-isotopes and low 87Sr/86Sr) component, such as St. Helena and Cook-Australs, exhibit high CaO/Al2O3, FeOT, and TiO2 and low SiO2 and Al2O3. EM1 (enriched mantle 1; intermediate 87Sr/86Sr and low 206Pb/204Pb; sampled by hotspots like Pitcairn and Kerguelen) and EM2 (enriched mantle 2; high 87Sr/86Sr and intermediate 206Pb/204Pb; sampled by hotspots like Samoa and Societies) exhibit higher K2O concentrations and K2O/TiO2 weight ratios than HIMU lavas. EM1 lavas exhibit the lowest CaO/Al2O3 in the OIB dataset, and this sets EM1 apart from EM2. A plot of CaO/Al2O3 vs K2O/TiO2 perfectly resolves the four mantle end member lavas. Melting processes (pressure, temperature and degree of melting) fail to provide an explanation for the full spectrum of major element concentrations in OIBs. Such processes also fail to explain the correlations between major elements and radiogenic isotopes. Instead, a long, time integrated history of various parent- daughter elements appears to be coupled to major element and/or volatile heterogeneity in the mantle source. End member lava compositions are compared with experimental partial melt compositions to place constraints on the lithological characteristics of the mantle end members.

  10. Over One-Half Billion Years of Head Conservation? Expression of an ems Class Gene in Hydractinia symbiolongicarpus (Cnidaria: Hydrozoa)

    Microsoft Academic Search

    Ofer Mokady; Matthew H. Dick; Dagmar Lackschewitz; Bernd Schierwater; Leo W. Buss

    1998-01-01

    We report the isolation of an empty spiracles class homeodomain-containing gene, Cn-ems, from the hydrozoan Hydractinia symbiolongicarpus, the first gene of this class characterized in a lower metazoan. Cn-ems was found to be expressed in the head of gastrozooids, specifically in endodermal epithelial cells of the taeniolae of the hypostome. Cn-ems is not expressed in gonozooids, which lack taeniolae. Experimental

  11. Effects of the estrogen antagonist EM652.HCl on energy balance and lipid metabolism in ovariectomized rats

    Microsoft Academic Search

    F Picard; Y Deshaies; J Lalonde; P Samson; C Labrie; A Bélanger; F Labrie; D Richard

    2000-01-01

    OBJECTIVE: The estrogen antagonist EM-652.HCl behaves as a highly potent and pure antiestrogen in human breast and uterine cancer cells. Because of its pure antiestrogenic activity in these cells, and because its prodrug, EM-800, reduces bone loss and decreases serum cholesterol and triglycerides in the rat, EM-652.HCl can be classified as a pure selective estrogen receptor modulator (SERM). This study

  12. Prokaryotic expression and identification of B- and T-cell combined epitopes of Em95 antigen of Echinococcus multilocularis

    PubMed Central

    Wang, Hongying; Zhang, Fengbo; Ma, Xiumin; Ma, Haimei; Zhu, Yuejie; Liu, Xianfei; Zhu, Min; Wen, Hao; Ding, Jianbing

    2014-01-01

    Objective: This study is to clone and identify B- and T-cell combined epitopes from Em95 antigen. Methods: The B- and T-cell combined epitopes were predicted using bioinformatic software. Two DNA sequences of Em95-1 (which contained the coding region of one B- and T-cell combined epitope) and Em95-2 (which contained the coding regions of two B- and T-cell combined epitopes) were amplified by PCR. Em95-1 and Em95-2 were cloned into pET32a vector for protein expression. Rabbit was immunized with the expressed proteins of rEm95-1 and rEm95-2 to produce polyclonal antibodies. The immunogenicity and antigenicity of rEm95-1 and rEm95-2 were examined by Western blot analysis. Results: The three B- and T-cell combined epitopes were successfully cloned and expressed in PET32a vector. The recombinant antigens of rEm95-1 and rEm95-2 could specifically bind the human serum from patients with alveolar echinococcosis and specifically bind the prepared polyclonal antibodies. Conclusion: Three B- and T-cell combined epitopes were successfully cloned with good immunogenicity and antigenicity. Our data suggest that B- and T-cell combined epitopes predicted from the Em95 antigen may be used for the construction of high-valence vaccines and as targets for prevention of echinococcosis. PMID:25197385

  13. EM-54 Technology Development In Situ Remediation Integrated Program. Annual report

    SciTech Connect

    Not Available

    1993-08-01

    The Department of Energy (DOE) established the Office of Technology Development (EM-50) as an element of Environmental Restoration and Waste Management (EM) in November 1989. EM manages remediation of all DOE sites as well as wastes from current operations. The goal of the EM program is to minimize risks to human health, safety and the environment, and to bring all DOE sites into compliance with Federal, state, and local regulations by 2019. EM-50 is charged with developing new technologies that are safer, more effective and less expensive than current methods. The In Situ Remediation Integrated Program (the subject of this report) is part of EM-541, the Environmental Restoration Research and Development Division of EM-54. The In Situ Remediation Integrated Program (ISR IP) was instituted out of recognition that in situ remediation could fulfill three important criteria: Significant cost reduction of cleanup by eliminating or minimizing excavation, transportation, and disposal of wastes; reduced health impacts on workers and the public by minimizing exposure to wastes during excavation and processing; and remediation of inaccessible sites, including: deep subsurfaces; in, under, and around buildings. Buried waste, contaminated soils and groundwater, and containerized wastes are all candidates for in situ remediation. Contaminants include radioactive wastes, volatile and non-volatile organics, heavy metals, nitrates, and explosive materials. The ISR IP tends to facilitate development of in situ remediation technologies for hazardous, radioactive, and mixed wastes in soils, groundwater, and storage tanks. Near-term focus is on containment of the wastes, with treatment receiving greater effort in future years.

  14. Electrokinetic effect combined with surface-charge assumption: a possible generation mechanism of coseismic EM signals

    NASA Astrophysics Data System (ADS)

    Ren, Hengxin; Wen, Jian; Huang, Qinghua; Chen, Xiaofei

    2015-02-01

    According to field observations, electromagnetic (EM) signals accompanying seismic waves can be recorded. The orders of magnitude of observed coseismic electric and magnetic signals associated with earthquakes are usually around 1 to 101 mV km-1 and 10-2 to 1 nT, respectively. In this paper, we carry out numerical simulation of coseismic EM signals associated with seismic waves due to electrokinetic effect and compare with field observations. The seismic source is represented by a finite fault measuring 15 × 9 km2 with a max slip displacement 1.5 m, corresponding to a Mw 5.9 earthquake. While using the EM surface boundary condition of continuous horizontal EM components, the magnetic signals only accompany the late-arriving S waves at receiver near the ground surface. This is obviously different from field observations. Thus, we adopt another EM surface boundary condition which assumes the ground surface carries surface charge. For the used half-space model, a surface-charge density magnitude |Qsc| in excess of 10-4 C m-2 is sufficient to make horizontal magnetic components clearly show up at the whole time duration of seismic waves. When |Qsc| increases, the contribution of surface-charge density to coseismic EM signals becomes more and more dominant comparing with that of the seismically induced streaming-current. We estimate the Qsc expected at the Earth's surface might be a value between -5 × 10-4 and -0.1 C m-2 by the comparison between numerical results and field observations. The vertical magnetic signals only accompany the late-arriving seismic waves, because they are theoretically only induced by SH wave. The field observation results of vertical magnetic signals may be resulted from the scattering effect or the seismic dynamo effect. We conclude that electrokinetic effect combined with surface-charge assumption is one possible generation mechanism of the observed coseismic EM signals.

  15. Cardiac repolarization and its relation to ventricular geometry and rate in reverse remodelling during antihypertensive therapy with irbesartan or atenolol: results from the SILVHIA study

    Microsoft Academic Search

    K Malmqvist; T Kahan; M Edner; L Bergfeldt

    2007-01-01

    Hypertensive left ventricular (LV) hypertrophy is associated with a substantial risk for malignant arrhythmias and sudden death. According to recent results, antihypertensive therapy with the angiotensin II type 1 receptor blocker irbesartan reverses both structural and electrical remodelling. However, the relation between the LV geometric pattern (concentric vs eccentric) and electrical reverse remodelling has not been characterized, neither has the

  16. SIMULTANEOUS ANALYSIS OF LOSARTAN POTASSIUM, ATENOLOL, AND HYDROCHLOROTHIAZIDE IN BULK AND IN TABLETS BY HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHY WITH UV ABSORPTION DENSITOMETRY

    Microsoft Academic Search

    S. R. Sathe; S. B. Bari

    SUMMARY A simple high-performance thin-layer chromatographic (HPTLC) method for separation and quantitative analysis of losartan potassium, ate- nolol, and hydrochlorothiazide in bulk and in pharmaceutical formulations has been established and validated. After extraction with methanol, sample and standard solutions were applied to prewashed silica gel plates and deve- loped with toluene-methanol-triethylamine 6.5:4:0.5 (v\\/v) as mobile pha- se. Zones were scanned

  17. Elimination of error factors, affecting EM and seismic inversions

    NASA Astrophysics Data System (ADS)

    Magomedov, M.; Zuev, M. A.; Korneev, V. A.; Goloshubin, G.; Zuev, J.; Brovman, Y.

    2013-12-01

    EM or seismic data inversions are affected by many factors, which may conceal the responses from target objects. We address here the contributions from the following effects: 1) Pre-survey spectral sensitivity factor. Preliminary information about a target layer can be used for a pre-survey estimation of the required frequency domain and signal level. A universal approach allows making such estimations in real time, helping the survey crew to optimize an acquisition process. 2) Preliminary velocities' identification and their dispersions for all the seismic waves, arising in a stratified media became a fast working tool, based on the exact analytical solution. 3) Vertical gradients effect. For most layers the log data scatter, requiring an averaging pattern. A linear gradient within each representative layer is a reasonable compromise between required inversion accuracy and forward modeling complexity. 4) An effect from the seismic source's radial component becomes comparable with vertical part for explosive sources. If this effect is not taken into account, a serious modeling error takes place. This problem has an algorithmic solution. 5) Seismic modeling is often based on different representations for a source formulated either for a force or to a potential. The wave amplitudes depend on the formulation, making an inversion result sensitive to it. 6) Asymmetrical seismic waves (modified Rayleigh) in symmetrical geometry around liquid fracture come from S-wave and merge with the modified Krauklis wave at high frequencies. A detail analysis of this feature allows a spectral range optimization for the proper wave's extraction. 7) An ultrasonic experiment was conducted to show different waves appearance for a super-thin water-saturated fracture between two Plexiglas plates, being confirmed by comparison with theoretical computations. 8) A 'sandwich effect' was detected by comparison with averaged layer's effect. This opens an opportunity of the shale gas direct identification from the surface measurements.

  18. Scalable and Interactive Segmentation and Visualization of Neural Processes in EM Datasets

    PubMed Central

    Jeong, Won-Ki; Beyer, Johanna; Hadwiger, Markus; Vazquez, Amelio; Pfister, Hanspeter; Whitaker, Ross T.

    2011-01-01

    Recent advances in scanning technology provide high resolution EM (Electron Microscopy) datasets that allow neuroscientists to reconstruct complex neural connections in a nervous system. However, due to the enormous size and complexity of the resulting data, segmentation and visualization of neural processes in EM data is usually a difficult and very time-consuming task. In this paper, we present NeuroTrace, a novel EM volume segmentation and visualization system that consists of two parts: a semi-automatic multiphase level set segmentation with 3D tracking for reconstruction of neural processes, and a specialized volume rendering approach for visualization of EM volumes. It employs view-dependent on-demand filtering and evaluation of a local histogram edge metric, as well as on-the-fly interpolation and ray-casting of implicit surfaces for segmented neural structures. Both methods are implemented on the GPU for interactive performance. NeuroTrace is designed to be scalable to large datasets and data-parallel hardware architectures. A comparison of NeuroTrace with a commonly used manual EM segmentation tool shows that our interactive workflow is faster and easier to use for the reconstruction of complex neural processes. PMID:19834227

  19. New Advances for a joint 3D inversion of multiple EM methods

    NASA Astrophysics Data System (ADS)

    Meqbel, N. M.; Ritter, O.

    2013-12-01

    Electromagnetic (EM) methods are routinely applied to image the subsurface from shallow to regional structures. Individual EM methods differ in their sensitivities towards resistive and conductive structures as well as in their exploration depths. Joint 3D inversion of multiple EM data sets can result in significantly better resolution of subsurface structures than the individual inversions. Proper weighting between different EM data is essential, however. We present a recently developed weighting algorithm to combine magnetotelluric (MT), controlled source EM (CSEM) and DC-geoelectric (DC) data. It is well known that MT data are mostly sensible to regional conductive structures, whereas, CSEM and DC data are more suitable to recover more shallow and resistive structures. Our new scheme is based on weighting individual components of the total data gradient after each model update. Norms of each data residual are used to assess how much weight individual components of the total data gradient must have to achieve an equal contribution of all data sets in the inverse model. A numerically efficient way to search for appropriate weighting factors could be established by applying a bi-diagonalization procedure to the sensitivity matrix. Thereby, the original inverse problem can be projected onto a smaller dimension in which the search of weighting factors is numerically cheap. We demonstrate the efficiency of the proposed weighting schemes and explore the model domain with synthetic data sets.

  20. PWR loss-of-coolant accident analysis capability of the WRAP-EM system

    SciTech Connect

    Gregory, M.V.; Beranek, F.

    1980-08-01

    The modular computational system known as the Water Reactor Analysis Package (WRAP) has been extended to provide the computational tools required to perform a complete analysis of loss-of-coolant accidents (LOCAs) in pressurized water reactors (PWR). The new system is known as the WRAP-EM (Evaluation Model) system and will be used by NRC to interpret and evaluate reactor vendor EM methods and computed results. The system for PWR-EM analysis is comprised of several computer codes which have been developed to analyze a particular phase of a LOCA. These codes include GAPCON for calculation of initial fuel conditions, WRAP (the previously developd SRL analog of RELAP4/MOD5) for analysis of the system blowdown and refill, the FLOOD option in WRAP for analysis of the reflood phase, and FRAP for the calculation of the behavior of the hot fuel pin. In addition, a PWR steady-state initialization procedure has been developed to provide the initial operating state of the reactor system. The PWR-EM system is operational and is being evaluated to determine the adequacy and consistency of the physical models employed for EM analysis.

  1. Single-particle cryo-EM of the ryanodine receptor channel in an aqueous environment

    PubMed Central

    Baker, Mariah R.; Fan, Guizhen; Serysheva, Irina I.

    2015-01-01

    Ryanodine receptors (RyRs) are tetrameric ligand-gated Ca2+ release channels that are responsible for the increase of cytosolic Ca2+ concentration leading to muscle contraction. Our current understanding of RyR channel gating and regulation is greatly limited due to the lack of a high-resolution structure of the channel protein. The enormous size and unwieldy shape of Ca2+ release channels make X-ray or NMR methods difficult to apply for high-resolution structural analysis of the full-length functional channel. Single-particle electron cryo-microscopy (cryo-EM) is one of the only effective techniques for the study of such a large integral membrane protein and its molecular interactions. Despite recent developments in cryo-EM technologies and break-through single-particle cryo-EM studies of ion channels, cryospecimen preparation, particularly the presence of detergent in the buffer, remains the main impediment to obtaining atomic-resolution structures of ion channels and a multitude of other integral membrane protein complexes. In this review we will discuss properties of several detergents that have been successfully utilized in cryo-EM studies of ion channels and the emergence of the detergent alternative amphipol to stabilize ion channels for structure-function characterization. Future structural studies of challenging specimen like ion channels are likely to be facilitated by cryo-EM amenable detergents or alternative surfactants.

  2. Código para imageamento indireto de estrelas em sistemas binarios: simulação de variações elipsoidais e do perfil das linhas

    NASA Astrophysics Data System (ADS)

    Souza, T. R.; Baptista, R.

    2003-08-01

    As estrelas secundárias em variáveis cataclí smicas (VCs) e binárias-x de baixa massa (BXBMs) são cruciais para o entendimento da origem, evolução e comportamento destas binárias interagentes. Elas são estrelas magneticamente ativas submetidas a condições ambientais extremas [e.g., estão muito próximas de uma fonte quente e irradiante; têm rotação extremamente rápida e forma distorcida; estão perdendo massa a taxas de 10-8-10-10 M¤/ano] que contribuem para que suas propriedades sejam distintas das de estrelas de mesma massa na seqüência principal. Por outro lado, o padrão de irradiação na face da secundária fornece informação sobre a geometria das estruturas de acréscimo em torno da estrela primária. Assim, a obtenção de imagens da superfície destas estrelas é de grande interesse astrofísico. A Tomografia Roche usa as variações no perfil das linhas de emissão/absorção da estrela secundária em função da fase orbital para mapear a distribuição de brilho em sua superfície. Neste trabalho apresentamos os resultados iniciais do desenvolvimento de um programa para o mapeamento da distribuição de brilho na superfí cie das estrelas secundárias em VCs e BXBMs com técnicas de astro-tomografia. Presentemente temos em operação um código que simula as variações no perfil das linhas em conseqüência de efeito Doppler resultante da combinação de rotação e translação de uma estrela em forma de lobo de Roche em torno do centro de massa da binária, em função da distribuição de brilho na superfície desta estrela. O código igualmente produz a curva de luz resultante das variações de aspecto da estrela em função da fase orbital (variações elipsoidais).

  3. DESEMPENHO AGRONÔMICO DE VARIEDADES DE MILHETO EM RAZÃO DA FENOLOGIA EM PRÉ-SAFRA AGRONOMIC ACTING OF CULTIVARS OF PEARL MILLET IN REASON OF THE FENOLOGY IN PRE-CROPPING

    Microsoft Academic Search

    Fabio Ribeiro; Renato Lara; Gilson Pereira; Antônio Joaquim; Braga Pereira; Shinayder Cristina SANTOS; Santiel Alves; João Paulo; Goulart de SOUSA

    RESUMO: A cultura do milheto (Pennisetum glaucum (l.) R. Br.) tem sido a principal opção para a formação de palhada no sistema de plantio direto no cerrado, sendo cultivado em safrinha ou em pré-safra. Para esta última época, todavia, são necessárias informações que possibilitem seu cultivo sem prejudicar a época de semeadura da cultura de verão. O objetivo do trabalho

  4. Posições de licenciandos em física sobre leituras no ensino médio da física moderna e contemporânea em textos de divulgação científica * Future high school teachers' positions about high school modern and contemporary physics popular science reading

    Microsoft Academic Search

    Ricardo Henrique Almeida Dias; Maria José; Pereira Monteiro de Almeida

    Temos por objetivo, neste estudo, compreender aspectos do imaginário de licenciandos, em física, sobre a possibilidade de utilização de textos de divulgação científica de física moderna e contemporânea em classes de ensino médio, através de uma atividade de leitura de textos de divulgação científica, contidos nas revistas Pesquisa Fapesp e Ciência Hoje, na qual os licenciandos responderam um questionário com

  5. EM algorithm applied for estimating non-stationary region boundaries using electrical impedance tomography

    NASA Astrophysics Data System (ADS)

    Khambampati, A. K.; Rashid, A.; Kim, B. S.; Liu, Dong; Kim, S.; Kim, K. Y.

    2010-04-01

    EIT has been used for the dynamic estimation of organ boundaries. One specific application in this context is the estimation of lung boundaries during pulmonary circulation. This would help track the size and shape of lungs of the patients suffering from diseases like pulmonary edema and acute respiratory failure (ARF). The dynamic boundary estimation of the lungs can also be utilized to set and control the air volume and pressure delivered to the patients during artificial ventilation. In this paper, the expectation-maximization (EM) algorithm is used as an inverse algorithm to estimate the non-stationary lung boundary. The uncertainties caused in Kalman-type filters due to inaccurate selection of model parameters are overcome using EM algorithm. Numerical experiments using chest shaped geometry are carried out with proposed method and the performance is compared with extended Kalman filter (EKF). Results show superior performance of EM in estimation of the lung boundary.

  6. Estudo e aplicação do código de desembaraçamento espectral - Korel - em sistemas triplos

    NASA Astrophysics Data System (ADS)

    Torres, K. B. V.; Vaz, L. P. R.

    2003-08-01

    O código KOREL é uma ferramenta adicional eficiente para a determinação simultânea de parâmetros orbitais espectroscópicos para o desembaraço de espectros individuais de sistemas estelares com até cinco componentes. Estudos já realizados (Torres,KBV,2002, Dissertação de Mestrado DF-ICEx-UFMG) mostram as limitações, aplicabilidade e eficiência do código para sistemas com duas componentes. Apresentamos, neste trabalho, a continuação dos estudos para sistemas com três componentes (sistemas hierárquicos), utilizando espectros sintéticos "gabaritos" de estrelas individuais em órbitas cujos parâmetros são conhecidos "a priori". Geramos os espectros compostos e verificamos como o código reproduz os parâmetros orbitais e espectros individuais em diversas situações físicas. É apresentado, ainda, uma discussão da aplicabilidade do código em sistemas reais como RV Crateris (Machado,ACM,1997, Dissertação de Mestrado DF-ICEx-UFMG), um sistema triplo cujas componentes eclipsantes estão, provavelmente, ainda na fase pré-sequência principal.

  7. Physics-based simulation of EM and SM in TSV-based 3D IC structures

    SciTech Connect

    Kteyan, Armen [Mentor Graphics Corp., 0012 Yerevan (Armenia); Sukharev, Valeriy [Mentor Graphics Corp., Fremont, CA 94538 (United States); Zschech, Ehrenfried [Fraunhofer Institute for Nondestructive Testing IZFP, D-01109 Dresden (Germany)

    2014-06-19

    Evolution of stresses in through-silicon-vias (TSVs) and in the TSV landing pad due to the stress migration (SM) and electromigration (EM) phenomena are considered. It is shown that an initial stress distribution existing in a TSV depends on its architecture and copper fill technology. We demonstrate that in the case of proper copper annealing the SM-induced redistribution of atoms results in uniform distributions of the hydrostatic stress and concentration of vacancies along each segment. In this case, applied EM stressing generates atom migration that is characterized by kinetics depending on the preexisting equilibrium concentration of vacancies. Stress-induced voiding in TSV is considered. EM induced voiding in TSV landing pad is analyzed in details.

  8. Direct and indirect measures of speech articulator motions using low power EM sensors

    SciTech Connect

    Barnes, T; Burnett, G; Gable, T; Holzrichter, J F; Ng, L

    1999-05-12

    Low power Electromagnetic (EM) Wave sensors can measure general properties of human speech articulator motions, as speech is produced. See Holzrichter, Burnett, Ng, and Lea, J.Acoust.Soc.Am. 103 (1) 622 (1998). Experiments have demonstrated extremely accurate pitch measurements (< 1 Hz per pitch cycle) and accurate onset of voiced speech. Recent measurements of pressure-induced tracheal motions enable very good spectra and amplitude estimates of a voiced excitation function. The use of the measured excitation functions and pitch synchronous processing enable the determination of each pitch cycle of an accurate transfer function and, indirectly, of the corresponding articulator motions. In addition, direct measurements have been made of EM wave reflections from articulator interfaces, including jaw, tongue, and palate, simultaneously with acoustic and glottal open/close signals. While several types of EM sensors are suitable for speech articulator measurements, the homodyne sensor has been found to provide good spatial and temporal resolution for several applications.

  9. Exploring conformational modes of macromolecular assemblies by multi-particle cryo-EM

    PubMed Central

    Spahn, Christian M.T.; Penczek, Pawel A.

    2009-01-01

    Summary Single particle cryo-electron microscopy (cryo-EM) is a technique aimed at structure determination of large macromolecular complexes in their unconstrained, physiological conditions. The power of the method has been demonstrated in selected studies where for highly symmetric molecules the resolution attained permitted backbone tracing. However, most molecular complexes appear to exhibit intrinsic conformational variability necessary to perform their functions. Therefore, it is now increasingly recognized that sample heterogeneity constitutes a major methodological challenge for cryo-EM. To overcome it dedicated experimental and particularly computational multi-particle approaches have been developed. Their applications point to the future of cryo-EM as an experimental method uniquely suited to visualize the conformational modes of large macromolecular complexes and machines. PMID:19767196

  10. A distribuição de velocidades na linha de visada em galáxias barradas vistas de face

    NASA Astrophysics Data System (ADS)

    Gadotti, D. A.; de Souza, R. E.

    2003-08-01

    Com o objetivo de realizar um estudo cinemático da componente vertical de barras em galáxias, obtivemos espectros de fenda longa de alta razão S/N ao longo dos eixos maior e menor de 14 galáxias barradas vistas de face, nos telescópios de 1.52m do ESO em La Silla, Chile, e de 2.3m do Steward Observatory em Kitt Peak, Arizona. Estes dados nos permitiram determinar a distribuição de velocidades das estrelas ao longo do eixo vertical das barras e discos destes sistemas, tanto no centro como em pontos que distam cerca de 5 e 20 segundos de arco do núcleo, correspondendo a distâncias de cerca de 0.7 e 2.8 kpc, respectivamente. Desta forma, a variação radial da distribuição de velocidades também pôde ser avaliada. Este tipo de análise tem raros exemplos na literatura por ser caro em termos de tempo de telescópio. Entretanto, é de fácil justificativa, considerando que traz novas informações que podem ser utilizadas para aperfeiçoar modelos teóricos acerca da formação e evolução de galáxias. Um algoritmo por nós desenvolvido foi utilizado para obter as distribuições de velocidades como Gaussianas generalizadas (polinômios de Gauss-Hermite), o que traz um ingrediente a mais neste tipo de estudo que, tradicionalmente, se utiliza de Gaussianas puras, uma hipótese nem sempre razoável. Apresentaremos os resultados deste trabalho, que incluem um diagnóstico para a identificação de barras recém formadas, e testes para o modelo isotérmico de discos. Mostraremos que: (i) a escolha das estrelas padrão em velocidade, e dos parâmetros da Gaussiana, deve ser muito bem justificada já que tem influência significativa nos resultados; (ii) muitas galáxias apresentam uma depressão na dispersão de velocidades na região central, que pode estar associada a um disco interno; e (iii) a dispersão de velocidades é constante ao longo da barra, nos eixos maior e menor, mas cai substancialmente quando se passa da barra para o disco.

  11. Los índices de mortalidad por cáncer de pulmón siguen bajando y contribuyen a reducción de índices generales de muertes por cáncer; Informe Anual a la Nación tiene una sección especial de los efectos de otras enfermedades en la supervivencia de pacientes

    Cancer.gov

    El Informe Anual a la Nación sobre el Estado del Cáncer (1975 a 2010), mostró un descenso más acelerado que en años anteriores de los índices de mortalidad por cáncer de pulmón. También contiene una sección especial que destaca los efectos significativos que tienen otras enfermedades en la supervivencia de pacientes con cáncer.

  12. Morphological Changes Induced by 6Month Treatment of Intact and Ovariectomized Mice with Tamoxifen and the Pure Antiestrogen EM800

    Microsoft Academic Search

    ANTIGONE SOURLA; SHOUQI LUO; CLAUDE LABRIE; ALAIN BELANGER; FERNAND LABRIE

    1997-01-01

    The present study compares the effects of tamoxifen and EM-800, both administered at the oral daily dose of 100 mg for 6 months, on the uterus, vagina, and mammary gland in the mouse at histopathological examination. Treatment of intact animals with EM-800 resulted in uterine and vaginal atrophy even greater than that achieved after ovariectomy, while the developmental growth of

  13. APLICAO DE AGENTES MVEIS EM REDES DE SENSORES SEM FIO PARA LOCALIZAO E SEGUIMENTO DE OBJETOS ALVOS MVEIS

    E-print Network

    Wagner, Flávio Rech

    APLICAÇÃO DE AGENTES MÓVEIS EM REDES DE SENSORES SEM FIO PARA LOCALIZAÇÃO E SEGUIMENTO DE OBJETOS sistema embarcado baseada em uma aplicação de localização e seguimento de objeto alvo utilizando redes de sensores sem fio (RSSF). Sendo os nós da rede fixos, realiza-se o seguimento do alvo utilizando agentes

  14. Suporte para vistas em ambientes de gesto de rede Palavras chave: Vistas, Gesto de Rede, CRC2000.

    E-print Network

    Rodrigues, Luís E.T.

    1 Suporte para vistas em ambientes de gestão de rede Palavras chave: Vistas, Gestão de Rede, CRC2000. Resumo Em sistemas de gestão de redes, uma vista representa uma perspectiva parcelar do universo sistema Scotty, uma conhecida plataforma de gestão de rede de domínio público. I. Introdução A grande

  15. Deteco Cooperativa de Intruses em Redes Carrier Ethernet Pan Jieke1, Joo Redol1, Miguel Correia2

    E-print Network

    Correia, Miguel

    Detecção Cooperativa de Intrusões em Redes Carrier Ethernet Pan Jieke1, João Redol1, Miguel Correia, 1749-016 Lisboa, Portugal mpc@di.fc.ul.pt Resumo Hoje em dia os elementos de rede (NEs) da camada 2 do interno. Este trabalho apresenta um esquema para proteger infra-estruturas de rede Carrier Ethernet de

  16. Teores de nutrientes na folha e nos grãos de aveia-preta em função da adubação com fósforo e potássio

    Microsoft Academic Search

    João Nakagawa; Ciro Antonio Rosolem

    2005-01-01

    A aveia-preta é uma gramínea rústica, pouco exigente, cultivada, principalmente, como forrageira de inverno e como cultura para adubação verde em sistemas de rotação. Apesar de sua importância, há poucos trabalhos em que foram avaliados os efeitos da adubação sobre os teores de nutrientes nas folhas ou nos grãos. Com o objetivo de estudar os efeitos de doses de P

  17. Title: A Low-Cost and Field Portable Electromechanical (E/M) Impedance Analyzer for Active Structural Health Monitoring

    E-print Network

    Giurgiutiu, Victor

    analyzer was compared to HP4194A impedance analyzer for detecting a disbond on a spacecraft test panel with piezoelectric wafer active sensors. INTRODUCTION The electromechanical (E/M) impedance method is a new embedded, the E/M impedance method is able to measure directly the high-frequency local impedance spectrum

  18. Factor Analysis with EM Algorithm Never Gives Improper Solutions when Sample Covariance and Initial Parameter Matrices Are Proper

    ERIC Educational Resources Information Center

    Adachi, Kohei

    2013-01-01

    Rubin and Thayer ("Psychometrika," 47:69-76, 1982) proposed the EM algorithm for exploratory and confirmatory maximum likelihood factor analysis. In this paper, we prove the following fact: the EM algorithm always gives a proper solution with positive unique variances and factor correlations with absolute values that do not exceed one, when the…

  19. O USO DE MODELOS MATEMÁTICOS NA ESTIMATIVA DA DENSIDADE BÁSICA DA MADEIRA EM PLANTIOS DE CLONES DE Eucalyptus sp

    Microsoft Academic Search

    Cláudio Roberto Thiersch; Jose Roberto Scolforo; Antonio Donizette de Oliveira; Gabriel Dehon; Sampaio Peçanha Rezende; Romualdo Maestri

    2 , em torno das quais foram cubadas 216 árvores. Foram avaliados 2 clones (híbridos de Eucalyptus grandis e Eucalyptus urophylla), nas idades 3, 4,5 e 6 anos, provenientes de três sítios, na região leste do Brasil, abrangendo a parte leste e nordeste do Estado do Espírito Santo e o extremo sul do Estado da Bahia. Em cada altura de

  20. TERESA PENA, PRESIDENTE DA SOCIEDADE PORTUGUESA DE FSICA, EM ENTREVISTA "UM PAS SEM CINCIA NO UM PAS

    E-print Network

    Instituto de Sistemas e Robotica

    TERESA PENA, PRESIDENTE DA SOCIEDADE PORTUGUESA DE FÍSICA, EM ENTREVISTA "UM PAÍS SEM CI�NCIA N�O � Teresa Pena, Professora do Instituto Superior Técnico e Presidente da Sociedade Portuguesa de Física, em entrevista à Revista Pontos de Vista. Saiba mais da Sociedade Portuguesa de Física, uma entidade que tem como