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Sample records for atlas level-1 barrel

  1. The CMS Level-1 Trigger Barrel Track Finder

    NASA Astrophysics Data System (ADS)

    Ero, J.; Evangelou, I.; Flouris, G.; Foudas, C.; Guiducci, L.; Loukas, N.; Manthos, N.; Papadopoulos, I.; Paradas, E.; Sotiropoulos, S.; Sphicas, P.; Triossi, A.; Wulz, C.

    2016-03-01

    The design and performance of the upgraded CMS Level-1 Trigger Barrel Muon Track Finder (BMTF) is presented. Monte Carlo simulation data as well as cosmic ray data from a CMS muon detector slice test have been used to study in detail the performance of the new track finder. The design architecture is based on twelve MP7 cards each of which uses a Xilinx Virtex-7 FPGA and can receive and transmit data at 10 Gbps from 72 input and 72 output fibers. According to the CMS Trigger Upgrade TDR the BMTF receives trigger primitive data which are computed using both RPC and DT data and transmits data from a number of muon candidates to the upgraded Global Muon Trigger. Results from detailed studies of comparisons between the BMTF algorithm results and the results of a C++ emulator are also presented. The new BMTF will be commissioned for data taking in 2016.

  2. The barrel modules of the ATLAS semiconductor tracker

    NASA Astrophysics Data System (ADS)

    Abdesselam, A.; Akimoto, T.; Allport, P. P.; Alonso, J.; Anderson, B.; Andricek, L.; Anghinolfi, F.; Apsimon, R. J.; Barbier, G.; Barr, A. J.; Batchelor, L. E.; Bates, R. L.; Batley, J. R.; Beck, G. A.; Bell, P. J.; Belymam, A.; Bernabeu, J.; Bethke, S.; Bizzell, J. P.; Bohm, J.; Brenner, R.; Brodbeck, T. J.; Broklova, Z.; Broz, J.; Bruckman De Renstrom, P.; Buttar, C. M.; Butterworth, J. M.; Carpentieri, C.; Carter, A. A.; Carter, J. R.; Charlton, D. G.; Cheplakov, A.; Chesi, E.; Chilingarov, A.; Chouridou, S.; Chu, M. L.; Cindro, V.; Ciocio, A.; Civera, J. V.; Clark, A.; Coe, P.; Colijn, A.-P.; Cornelissen, T.; Cosgrove, D. P.; Costa, M. J.; Dabrowski, W.; Dalmau, J.; Danielsen, K. M.; Dawson, I.; Demirkoz, B.; Dervan, P.; Dolezal, Z.; Donega, M.; D'Onofrio, M.; Dorholt, O.; Dowell, J. D.; Drasal, Z.; Duerdoth, I. P.; Dwuznik, M.; Eckert, S.; Ekelof, T.; Eklund, L.; Escobar, C.; Fadeyev, V.; Feld, L.; Ferrari, P.; Ferrere, D.; Fiorini, L.; Fortin, R.; Foster, J. M.; Fox, H.; Fraser, T. J.; Freestone, J.; French, R.; Fuster, J.; Gadomski, S.; Gallop, B. J.; García, C.; Garcia-Navarro, J. E.; Gibson, M. D.; Gibson, S.; Gilchriese, M. G. D.; Godlewski, J.; Gonzalez-Sevilla, S.; Goodrick, M. J.; Gorisek, A.; Gornicki, E.; Greenall, A.; Grigson, C.; Grillo, A. A.; Grosse-Knetter, J.; Haber, C.; Hara, K.; Hartjes, F. G.; Hauff, D.; Hawes, B. M.; Haywood, S. J.; Hessey, N. P.; Hicheur, A.; Hill, J. C.; Hollins, T. I.; Holt, R.; Howell, D. F.; Hughes, G.; Huse, T.; Ibbotson, M.; Ikegami, Y.; Issever, C.; Jackson, J. N.; Jakobs, K.; Jarron, P.; Johansen, L. G.; Jones, T. J.; Jones, T. W.; de Jong, P.; Joos, D.; Jovanovic, P.; Kachiguine, S.; Kaplon, J.; Kato, Y.; Ketterer, C.; Kobayashi, H.; Kodys, P.; Koffeman, E.; Kohout, Z.; Kohriki, T.; Kondo, T.; Koperny, S.; Kramberger, G.; Kubik, P.; Kudlaty, J.; Kuwano, T.; Lacasta, C.; LaMarra, D.; Lane, J. B.; Lee, S.-C.; Lester, C. G.; Limper, M.; Lindsay, S.; Llatas, M. C.; Loebinger, F. K.; Lozano, M.; Ludwig, I.; Ludwig, J.; Lutz, G.; Lys, J.; Maassen, M.; Macina, D.; Macpherson, A.; MacWaters, C.; McMahon, S. J.; McMahon, T. J.; Magrath, C. A.; Malecki, P.; Mandić, I.; Mangin-Brinet, M.; Martí-García, S.; Martinez-Mckinney, G. F. M.; Matheson, J. M. C.; Matson, R. M.; Meinhardt, J.; Mikulec, B.; Mikuž, M.; Minagawa, M.; Mistry, J.; Mitsou, V.; Modesto, P.; Moëd, S.; Mohn, B.; Moorhead, G.; Morin, J.; Morris, J.; Morrissey, M.; Moser, H.-G.; Muijs, A. J. M.; Murray, W. J.; Nagai, K.; Nakamura, K.; Nakamura, Y.; Nakano, I.; Nichols, A.; Nicholson, R.; Nickerson, R. B.; Nisius, R.; O'Shea, V.; Oye, O. K.; Palmer, M. J.; Parker, M. A.; Parzefall, U.; Pater, J. R.; Peeters, S. J. M.; Pellegrini, G.; Pernegger, H.; Perrin, E.; Phillips, A.; Phillips, P. W.; Poltorak, K.; Pospisil, S.; Postranecky, M.; Pritchard, T.; Rafi, J. M.; Ratoff, P. N.; Reznicek, P.; Richter, R. H.; Robinson, D.; Roe, S.; Rosenbaum, F.; Rudge, A.; Runge, K.; Sadrozinski, H. F. W.; Sandaker, H.; Saxon, D. H.; Schieck, J.; Sedlak, K.; Seiden, A.; Sengoku, H.; Sfyrla, A.; Shimma, S.; Smith, K. M.; Smith, N. A.; Snow, S. W.; Solar, M.; Solberg, A.; Sopko, B.; Sospedra, L.; Spencer, E.; Stanecka, E.; Stapnes, S.; Stastny, J.; Stodulski, M.; Stugu, B.; Szczygiel, R.; Tanaka, R.; Tappern, G.; Taylor, G.; Teng, P. K.; Terada, S.; Thompson, R. J.; Titov, M.; Toczek, B.; Tovey, D. R.; Tricoli, A.; Turala, M.; Turner, P. R.; Tyndel, M.; Ullán, M.; Unno, Y.; Van der Kraaij, E.; van Vulpen, I.; Viehhauser, G.; Villani, E. G.; Vorobel, V.; Vos, M.; Wallny, R.; Warren, M. R. M.; Wastie, R. L.; Weber, M.; Weidberg, A. R.; Weilhammer, P.; Wells, P. S.; Wilder, M.; Wilhelm, I.; Wilson, J. A.; Wolter, M.

    2006-12-01

    This paper describes the silicon microstrip modules in the barrel section of the SemiConductor Tracker (SCT) of the ATLAS experiment at the CERN Large Hadron Collider (LHC). The module requirements, components and assembly techniques are given, as well as first results of the module performance on the fully assembled barrels that make up the detector being installed in the ATLAS experiment.

  3. Operation of the Upgraded ATLAS Level-1 Central Trigger System

    NASA Astrophysics Data System (ADS)

    Glatzer, Julian

    2015-12-01

    The ATLAS Level-1 Central Trigger (L1CT) system is a central part of ATLAS data-taking and has undergone a major upgrade for Run 2 of the LHC, in order to cope with the expected increase of instantaneous luminosity of a factor of two with respect to Run 1. The upgraded hardware offers more flexibility in the trigger decisions due to the factor of two increase in the number of trigger inputs and usable trigger channels. It also provides an interface to the new topological trigger system. Operationally - particularly useful for commissioning, calibration and test runs - it allows concurrent running of up to three different subdetector combinations. An overview of the operational software framework of the L1CT system with particular emphasis on the configuration, controls and monitoring aspects is given. The software framework allows a consistent configuration with respect to the ATLAS experiment and the LHC machine, upstream and downstream trigger processors, and the data acquisition system. Trigger and dead-time rates are monitored coherently at all stages of processing and are logged by the online computing system for physics analysis, data quality assurance and operational debugging. In addition, the synchronisation of trigger inputs is watched based on bunch-by-bunch trigger information. Several software tools allow for efficient display of the relevant information in the control room in a way useful for shifters and experts. The design of the framework aims at reliability, flexibility, and robustness of the system and takes into account the operational experience gained during Run 1. The Level-1 Central Trigger was successfully operated with high efficiency during the cosmic-ray, beam-splash and first Run 2 data taking with the full ATLAS detector.

  4. Measurement of the response of the ATLAS liquid argon barrel calorimeter to electrons at the 2004 combined test-beam

    SciTech Connect

    Aharrouche, M.; Ma, H.; Adam-Bourdarios, C.; Aleksa, M.; Banfi, D.; Benchekroun, D.; Benslama, K.; Boonekamp, M.; Carli, T.; Carminati, L.; Chen, H.; Citterio, M.; Dannheim, D.; Delmastro, M.; Derue, F.; Di Girolamo, B.; El Kacimi, M.; Fanti, M.; Froeschl, R.; Fournier, D.; Grahn, K.-J.; Kado, M.; Kerschen, N.; Lafaye, R.; Laforge, B.; Lampl, W.; Laplace, S.; Lechowski, M.; Lelas, D.; Liang, Z.; Loureiro, K.; Lund-Jensen, B.; Mandelli, L.; Mazzanti, M.; McPherson, R.; Meng, Z.; Paganis, S.; Prieur, D.; Puzo, P.; Ridel, M.; Riu, I.; Rousseau, D.; Sauvage, G.; Schwemling, P.; Simon, S.; Spano, F.; Straessner, A.; Tarrade, F.; Tartarelli, F.; Thioye, M.; Unal, G.; Wilkens, H.; Wingerter-Seez, I. and Zhang, H.

    2010-03-11

    During summer and fall 2004, the response of a full slice of the ATLAS barrel detector to different particles was studied in controlled beam. One module of the ATLAS liquid argon barrel calorimeter - identical to the production modules and read out by the final front-end and back-end electronics - was used for electromagnetic calorimetry. This paper presents and discusses the electron performance of the LAr barrel calorimeter, including linearity, uniformity, and resolution with different amounts of material upstream the calorimeter and energies ranging from 1 to 250 GeV.

  5. L1Track: A fast Level 1 track trigger for the ATLAS high luminosity upgrade

    NASA Astrophysics Data System (ADS)

    Cerri, Alessandro

    2016-07-01

    With the planned high-luminosity upgrade of the LHC (HL-LHC), the ATLAS detector will see its collision rate increase by approximately a factor of 5 with respect to the current LHC operation. The earliest hardware-based ATLAS trigger stage ("Level 1") will have to provide a higher rejection factor in a more difficult environment: a new improved Level 1 trigger architecture is under study, which includes the possibility of extracting with low latency and high accuracy tracking information in time for the decision taking process. In this context, the feasibility of potential approaches aimed at providing low-latency high-quality tracking at Level 1 is discussed.

  6. Tracking for the Atlas Level 1 Trigger for the High Luminosity Lhc

    NASA Astrophysics Data System (ADS)

    Sutton, M. R.

    2014-06-01

    At the HL-LHC, the increased luminosity will result in up to 200 pile-up interactions per bunch crossing. One of the greatest challenges for ATLAS will be to keep the Level 1 Trigger pT thresholds low enough to maintain high trigger efficiency for all interesting physics. The proposed two-stage design of the ATLAS Level 1 Trigger, and the incorporation of a Level-1 track trigger is described. The requirements and implications for the tracker readout architecture, and estimates of readout latency based on a detailed discrete event simulation of the data flow in the tracker front-end electronics are also presented.

  7. Upgrading the ATLAS barrel tracker for the super-LHC

    NASA Astrophysics Data System (ADS)

    Bates, Richard L.; ATLAS ID Collaboration

    2009-08-01

    It has been proposed to increase the luminosity of the large hadron collider (LHC) at CERN by an order of magnitude, with the upgraded machine dubbed super-LHC. The ATLAS experiment will require a new tracker for this high-luminosity operation due to radiation damage and event density. In order to cope with the order of magnitude increase in pile-up backgrounds at the higher luminosity, an all-silicon tracker is being designed. The new strip detector will use significantly shorter strips than the current silicon tracker in order to minimize the occupancy. As the increased luminosity will mean a corresponding increase in radiation dose, a new generation of extremely radiation-hard silicon detectors is required. An R&D program is underway to develop silicon sensors with sufficient radiation hardness. New front-end electronics and readout systems are being designed to cope with the higher data rates. The challenges facing the sensors and the cooling and mechanical support will be discussed. A possible tracker layout will be described.

  8. The Common Cryogenic Test Facility for the ATLAS Barrel and End-Cap Toroid Magnets

    NASA Astrophysics Data System (ADS)

    Delruelle, N.; Haug, F.; Junker, S.; Passardi, G.; Pengo, R.; Pirotte, O.

    2004-06-01

    The large ATLAS toroidal superconducting magnet made of the Barrel and two End-Caps needs extensive testing at the surface of the individual components prior to their final assembly into the underground cavern of LHC. A cryogenic test facility specifically designed for cooling sequentially the eight coils making the Barrel Toroid (BT) has been fully commissioned and is now ready for final acceptance of these magnets. This facility, originally designed for testing individually the 46 tons BT coils, will be upgraded to allow the acceptance tests of the two End-Caps, each of them having a 160 tons cold mass. The integrated system mainly comprises a 1.2 kW@4.5 K refrigerator, a 10 kW liquid-nitrogen precooler, two cryostats housing liquid helium centrifugal pumps of respectively 80 g/s and 600 g/s nominal flow and specific instrumentation to measure the thermal performances of the magnets. This paper describes the overall facility with particular emphasis to the cryogenic features adopted to match the specific requirements of the magnets in the various operating scenarios.

  9. The Common Cryogenic Test Facility for the ATLAS Barrel and End-Cap Toroid Magnets

    SciTech Connect

    Delruelle, N.; Haug, F.; Junker, S.; Passardi, G.; Pengo, R.; Pirotte, O.

    2004-06-23

    The large ATLAS toroidal superconducting magnet made of the Barrel and two End-Caps needs extensive testing at the surface of the individual components prior to their final assembly into the underground cavern of LHC. A cryogenic test facility specifically designed for cooling sequentially the eight coils making the Barrel Toroid (BT) has been fully commissioned and is now ready for final acceptance of these magnets. This facility, originally designed for testing individually the 46 tons BT coils, will be upgraded to allow the acceptance tests of the two End-Caps, each of them having a 160 tons cold mass. The integrated system mainly comprises a 1.2 kW at 4.5 K refrigerator, a 10 kW liquid-nitrogen precooler, two cryostats housing liquid helium centrifugal pumps of respectively 80 g/s and 600 g/s nominal flow and specific instrumentation to measure the thermal performances of the magnets. This paper describes the overall facility with particular emphasis to the cryogenic features adopted to match the specific requirements of the magnets in the various operating scenarios.

  10. The ATLAS Level-1 Muon Topological Trigger Information for Run 2 of the LHC

    NASA Astrophysics Data System (ADS)

    Artz, S.; Bauss, B.; Boterenbrood, H.; Buescher, V.; Cerqueira, A. S.; Degele, R.; Dhaliwal, S.; Ellis, N.; Farthouat, P.; Galster, G.; Ghibaudi, M.; Glatzer, J.; Haas, S.; Igonkina, O.; Jakobi, K.; Jansweijer, P.; Kahra, C.; Kaluza, A.; Kaneda, M.; Marzin, A.; Ohm, C.; Silva Oliveira, M. V.; Pauly, T.; Poettgen, R.; Reiss, A.; Schaefer, U.; Schaeffer, J.; Schipper, J. D.; Schmieden, K.; Schreuder, F.; Simioni, E.; Simon, M.; Spiwoks, R.; Stelzer, J.; Tapprogge, S.; Vermeulen, J.; Vogel, A.; Zinser, M.

    2015-02-01

    For the next run of the LHC, the ATLAS Level-1 trigger system will include topological information on trigger objects from the calorimeters and muon detectors. In order to supply coarse grained muon topological information, the existing MUCTPI (Muon-to-Central-Trigger-Processor Interface) system has been upgraded. The MIOCT (Muon Octant) module firmware has been then modified to extract, encode and send topological information through the existing MUCTPI electrical trigger outputs. The topological information from the muon detectors will be sent to the Level-1 Topological Trigger Processor (L1Topo) through the MUCTPI-to-Level-1-Topological-Processor (MuCTPiToTopo) interface. Examples of physics searches involving muons are: search for Lepton Flavour Violation, Bs-physics, Beyond the Standard Model (BSM) physics and others. This paper describes the modifications to the MUCTPI and its integration with the full trigger chain.

  11. Upgrade of the ATLAS Level-1 Trigger with event topology information

    NASA Astrophysics Data System (ADS)

    Simioni, E.; Artz, S.; Bauβ, B.; Büscher, V.; Jakobi, K.; Kaluza, A.; Kahra, C.; Palka, M.; Reiβ, A.; Schäffer, J.; Schäfer, U.; Schulte, A.; Simon, M.; Tapprogge, S.; Vogel, A.; Zinser, M.

    2015-12-01

    The Large Hadron Collider (LHC) in 2015 will collide proton beams with increased luminosity from 1034 up to 3 × 1034cm-2s-1. ATLAS is an LHC experiment designed to measure decay properties of high energetic particles produced in the protons collisions. The higher luminosity places stringent operational and physical requirements on the ATLAS Trigger in order to reduce the 40MHz collision rate to a manageable event storage rate of 1kHz while at the same time, selecting those events with valuable physics meaning. The Level-1 Trigger is the first rate-reducing step in the ATLAS Trigger, with an output rate of 100kHz and decision latency of less than 2.5µs. It is composed of the Calorimeter Trigger (L1Calo), the Muon Trigger (L1Muon) and the Central Trigger Processor (CTP). By 2015, there will be a new electronics element in the chain: the Topological Processor System (L1Topo system). The L1Topo system consist of a single AdvancedTCA shelf equipped with three L1Topo processor blades. It will make it possible to use detailed information from L1Calo and L1Muon processed in individual state-of-the-art FPGA processors. This allows the determination of angles between jets and/or leptons and calculates kinematic variables based on lists of selected/sorted objects. The system is designed to receive and process up to 6Tb/s of real time data. The paper reports the relevant upgrades of the Level-1 trigger with focus on the topological processor design and commissioning.

  12. Production summary for extended barrel module fabrication at Argonne for the ATLAS tile calorimeter.

    SciTech Connect

    Guarino, V.; Hill, N.; Petereit, E.; Skrzecz, F.; Wood, K.; Proudfoot, J.; Anderson, S.; Caird, A.; Keyser, C.; Kocenko, L.; Matijas, Z.; Nephew, T.; Stanek, R.; Franchini, F.; High Energy Physics

    2007-11-14

    The Tile Calorimeter is one of the main hadronic calorimeters to be used in the ATLAS experiment at CERN [1,2]. It is a steel/scintillator sampling calorimeter which is built by stacking 64 segments in azimuth and 3 separate cylinders to provide a total structure whose length is approximately 12m and whose diameter is a little over 8.4m. It has a total weight of about 2630 metric tons. Important features of this calorimeter are: A minimum gap (1.5mm) between modules in azimuth; Pockets in the structure to hold the scintillator tiles; Recessed channels at the edges of the module into which the readout fibers will sit; and Holes in the structure through which a radioactive source will pass. The mechanical structure for one of the 3 calorimeter sections, the Extended Barrel (EBA) was constructed at Argonne. A schematic of the calorimeter sampling structure and the layout of one of the 64 segments, termed a module, are shown in figure 1. Each module comprises mechanically of a precision machined, structural girder to which 10 submodules are bolted. One of these submodules, the ITC, has a customized shape to accommodate services for other detector elements. Each submodule weighs 850Kg and the assembled mechanical structure of the module weighs approximately 9000Kg (a fully instrumented Extended Barrel modules weighs {approx}9600Kg). A crucial issue for the tile calorimeter assembly is the minimization of the un-instrumented gap between modules when they are stacked on top of each other during final assembly. The design goal was originally 1mm gap which was eventually relaxed to 1.5mm following a careful evaluation of all tolerances in the construction and assembly process as shown in figure 2 [3]. Submodules for this assembly were produced at 4 locations [4] using tooling and procedures which were largely identical [5]. An important issue was the height of each submodule on the stacking fixture on which they were fabricated as this defines the length along the girder

  13. Results of the Cryogenic Tests of the Superconducting Magnets Forming the Barrel Toroid of the Atlas Experiment

    NASA Astrophysics Data System (ADS)

    Barth, K.; Delruelle, N.; Dudarev, A.; Junker, S.; Pengo, R.; Pirotte, O.; Berriaud, C.

    2006-04-01

    The Barrel Toroid magnet of the ATLAS experiment will be built from eight 25 m × 5 m racetrack shaped superconducting coils that are symmetrically placed around the central axis of the detector. Prior to their final assembly in the underground cavern of the LHC, these magnets are individually tested at ground level in order to verify the expected overall performances. A dedicated facility has been commissioned and the testing of the coils, at their nominal electrical and thermal operating conditions, has been carried out. The paper presents the results obtained during the cool-down phase from ambient temperature, the steady-state operation at 4.5 K, the 20 kA current ramping up/down and the thermal recovery after a fast energy dump of up to 138 MJ stored energy. Included are the measurements of the various thermal loads in both static and dynamic conditions.

  14. Barrel alignment fixture

    NASA Astrophysics Data System (ADS)

    Sheeley, J. D.

    1981-04-01

    Fabrication of slapper type detonator cables requires bonding of a thin barrel over a bridge. Location of the barrel hole with respect to the bridge is critical: the barrel hole must be centered over the bridge uniform spacing on each side. An alignment fixture which permits rapid adjustment of the barrel position with respect to the bridge is described. The barrel is manipulated by pincer-type fingers which are mounted on a small x-y table equipped with micrometer adjustments. Barrel positioning, performed under a binocular microscopy, is rapid and accurate. After alignment, the microscope is moved out of position and an infrared (IR) heat source is aimed at the barrel. A 5-second pulse of infrared heat flows the adhesive under the barrel and bonds it to the cable. Sapphire and Fotoform glass barrels were bonded successfully with the alignment fixture.

  15. The PANDA Barrel DIRC

    NASA Astrophysics Data System (ADS)

    Dzhygadlo, R.; Schwarz, C.; Belias, A.; Gerhardt, A.; Götzen, K.; Kalicy, G.; Krebs, M.; Lehmann, D.; Nerling, F.; Patsyuk, M.; Peters, K.; Schepers, G.; Schmitt, L.; Schwiening, J.; Traxler, M.; Zühlsdorf, M.; Britting, A.; Eyrich, W.; Lehmann, A.; Pfaffinger, M.; Uhlig, F.; Düren, M.; Etzelmüller, E.; Föhl, K.; Hayrapetyan, A.; Kröck, B.; Merle, O.; Rieke, J.; Schmidt, M.; Cowie, E.; Keri, T.; Achenbach, P.; Cardinali, M.; Hoek, M.; Lauth, W.; Schlimme, S.; Sfienti, C.; Thiel, M.

    2016-05-01

    The PANDA detector at the international accelerator Facility for Antiproton and Ion Research in Europe (FAIR) addresses fundamental questions of hadron physics. Experiments concerning charmonium spectroscopy, the search for hybrids and glueballs and the interaction of hidden and open charm particles with nucleons and nuclei will be performed with antiproton beams impinging on hydrogen or nuclear targets. Cooled beams allow the precision scan of resonances in formation experiments. The momentum range of the antiproton beam between 1.5 GeV/c and 15 GeV/c tests predictions by perturbation theory and will reveal deviations originating from strong QCD . An excellent hadronic particle identification will be accomplished by DIRC (Detection of Internally Reflected Cherenkov light) counters. The design for the barrel region is based on the successful BaBar DIRC with several key improvements, such as fast photon timing and a compact imaging region. DIRC designs based on different radiator geometries with several focusing options were studied in simulation. The performance of each design was characterized in terms of photon yield and single photon Cherenkov angle resolution. Selected design options were implemented in prototypes and tested with hadronic particle beams at GSI and CERN.

  16. BARREL Team Launching 20 Balloons

    NASA Video Gallery

    A movie made by the NASA-Funded Balloon Array for Radiation belt Relativistic Electron Losses, or BARREL, team on their work launching 20 balloons in Antarctica during the Dec. 2013/Jan. 2014 campa...

  17. ATLAS LAr calorimeters readout electronics upgrade R&D for sLHC

    NASA Astrophysics Data System (ADS)

    Chen, Hucheng; ATLAS Liquid Argon Calorimeter Group

    2011-04-01

    The ATLAS Liquid Argon (LAr) calorimeters consist of an electromagnetic barrel calorimeter and two end-caps with electromagnetic, hadronic and forward calorimeters. A total of 182,468 signals are digitized and processed real-time on detector, to provide energy and time deposited in each detector element at every occurrence of the Level-1 trigger. A luminosity upgrade of the LHC will occur in the years ~2020. The current readout electronics will need to be upgraded to sustain the higher radiation levels. A completely innovative readout scheme is being developed. The front-end readout will send out data continuously at each bunch crossing through high speed radiation resistant optical links, the data will be processed real-time with the possibility of implementing trigger algorithms. This article is an overview of the R&D activities and architectural studies the ATLAS LAr Calorimeter Group is developing.

  18. Assembly of 5.5-Meter Diameter Developmental Barrel Segments for the Ares I Upper Stage

    NASA Technical Reports Server (NTRS)

    Carter, Robert W.

    2011-01-01

    Full scale assembly welding of Ares I Upper Stage 5.5-Meter diameter cryogenic tank barrel segments has been performed at the Marshall Space Flight Center (MSFC). One full-scale developmental article produced under the Ares 1 Upper Stage project is the Manufacturing Demonstration Article (MDA) Barrel. This presentation will focus on the welded assembly of this barrel section, and associated lessons learned. Among the MDA articles planned on the Ares 1 Program, the Barrel was the first to be completed, primarily because the process of manufacture from piece parts (barrel panels) utilized the most mature friction stir process planned for use on the Ares US program: Conventional fixed pin Friction Stir Welding (FSW). This process is in use on other space launch systems, including the Shuttle s External Tank, the Delta IV common booster core, the Delta II, and the Atlas V rockets. The goals for the MDA Barrel development were several fold: 1) to prove out Marshall Space Flight Center s new Vertical Weld Tool for use in manufacture of cylindrical barrel sections, 2) to serve as a first run for weld qualification to a new weld specification, and 3) to provide a full size cylindrical section for downstream use in precision cleaning and Spray-on Foam Insulation development. The progression leading into the welding of the full size barrel included sub scale panel welding, subscale cylinder welding, a full length confidence weld, and finally, the 3 seamed MDA barrel processing. Lessons learned on this MDA program have been carried forward into the production tooling for the Ares 1 US Program, and in the use of the MSFC VWT in processing other large scale hardware, including two 8.4 meter diameter Shuttle External Tank barrel sections that are currently being used in structural analysis to validate shell buckling models.

  19. Direct 3D Analyses Reveal Barrel-Specific Vascular Distribution and Cross-Barrel Branching in the Mouse Barrel Cortex.

    PubMed

    Wu, Jingpeng; Guo, Congdi; Chen, Shangbin; Jiang, Tao; He, Yong; Ding, Wenxiang; Yang, Zhongqin; Luo, Qingming; Gong, Hui

    2016-01-01

    Whether vascular distribution is spatially specific among cortical columns is a fundamental yet controversial question. Here, we have obtained 1-μm resolution 3D datasets that cover the whole mouse barrel cortex by combining Nissl staining with micro-optical sectioning tomography to simultaneously visualize individual cells and blood vessels, including capillaries. Pinpointing layer IV of the posteromedial barrel subfield, direct 3D reconstruction and quantitative analysis showed that (1) penetrating vessels preferentially locate in the interbarrel septa/barrel wall (75.1%) rather than the barrel hollows, (2) the branches of 70% penetrating vessels only reach the neighboring but not always all the neighboring barrels and the other 30% extend beyond the neighboring barrels and may provide cross-barrel blood supply or drainage, (3) the branches of 59.6% penetrating vessels reach all the neighboring barrels, while the rest only reach part of them, and (4) the length density of microvessels in the interbarrel septa/barrel wall is lower than that in the barrel hollows with a ratio of 0.92. These results reveal that the penetrating vessels and microvessels exhibit a barrel-specific organization, whereas the branches of penetrating vessels do not, which suggests a much more complex vascular distribution pattern among cortical columns than previously thought. PMID:25085882

  20. The PANDA Barrel DIRC detector

    NASA Astrophysics Data System (ADS)

    Hoek, M.; Dzhygadlo, R.; Gerhardt, A.; Götzen, K.; Hohler, R.; Kalicy, G.; Kumawat, H.; Lehmann, D.; Lewandowski, B.; Patsyuk, M.; Peters, K.; Schepers, G.; Schmitt, L.; Schwarz, C.; Schwiening, J.; Traxler, M.; Zühlsdorf, M.; Dodokhov, V. Kh.; Britting, A.; Eyrich, W.; Lehmann, A.; Uhlig, F.; Düren, M.; Föhl, K.; Hayrapetyan, A.; Kröck, B.; Merle, O.; Rieke, J.; Cowie, E.; Keri, T.; Montgomery, R.; Rosner, G.; Achenbach, P.; Cardinali, M.; Lauth, W.; Sfienti, C.; Thiel, M.; Bühler, P.; Gruber, L.; Marton, J.; Suzuki, K.

    2014-12-01

    The PANDA experiment at the new Facility for Antiproton and Ion Research in Europe (FAIR) at GSI, Darmstadt, will study fundamental questions of hadron physics and QCD using high-intensity cooled antiproton beams with momenta between 1.5 and 15 GeV/c. Efficient Particle Identification for a wide momentum range and the full solid angle is required for reconstructing the various physics channels of the PANDA program. Hadronic Particle Identification in the barrel region of the detector will be provided by a DIRC counter. The design is based on the successful BABAR DIRC with important improvements, such as focusing optics and fast photon timing. Several of these improvements, including different radiator geometries and optics, were tested in particle beams at GSI and at CERN. The evolution of the conceptual design of the PANDA Barrel DIRC and the performance of complex prototypes in test beam campaigns will be discussed.

  1. MISR Level 1A Products

    Atmospheric Science Data Center

    2013-04-01

    ... MISR Level 1A Products Level 1A Engineering Data File Type 1 and Level 1A Navigation Data Processing ... Product Specification Rev K  (PDF). Transparent software rebuild with Irix 6.5.2 OS. F01_0007 (FM_ENG), ...

  2. 15 CFR 241.2 - Legal standard barrels.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., VEGETABLES AND OTHER DRY COMMODITIES, AND FOR CRANBERRIES § 241.2 Legal standard barrels. (a) Any barrel..., other than cranberries, in section 1 of the standard-barrel law, or any barrel or a subdivision thereof... than cranberries, or a legal subdivision thereof. No other barrel or subdivision in barrel form is...

  3. 15 CFR 241.2 - Legal standard barrels.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., VEGETABLES AND OTHER DRY COMMODITIES, AND FOR CRANBERRIES § 241.2 Legal standard barrels. (a) Any barrel..., other than cranberries, in section 1 of the standard-barrel law, or any barrel or a subdivision thereof... than cranberries, or a legal subdivision thereof. No other barrel or subdivision in barrel form is...

  4. 15 CFR 241.2 - Legal standard barrels.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., VEGETABLES AND OTHER DRY COMMODITIES, AND FOR CRANBERRIES § 241.2 Legal standard barrels. (a) Any barrel..., other than cranberries, in section 1 of the standard-barrel law, or any barrel or a subdivision thereof... than cranberries, or a legal subdivision thereof. No other barrel or subdivision in barrel form is...

  5. 15 CFR 241.2 - Legal standard barrels.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., VEGETABLES AND OTHER DRY COMMODITIES, AND FOR CRANBERRIES § 241.2 Legal standard barrels. (a) Any barrel..., other than cranberries, in section 1 of the standard-barrel law, or any barrel or a subdivision thereof... than cranberries, or a legal subdivision thereof. No other barrel or subdivision in barrel form is...

  6. The OPAL muon barrel detector

    NASA Astrophysics Data System (ADS)

    Akers, R. J.; Allison, J.; Ashton, P.; Bahan, G. A.; Baines, J. T. M.; Banks, J. N.; Barlow, R. J.; Barnett, S.; Beeston, C.; Chrin, J. T. M.; Clowes, S. G.; Davies, O. W.; Duerdoth, I. P.; Hinde, P. S.; Hughes-Jones, R. E.; Lafferty, G. D.; Loebinger, F. K.; Macbeth, A. A.; McGowan, R. F.; Moss, M. W.; Murphy, P. G.; Nijjhar, B.; O'Dowd, A. J. P.; Pawley, S. J.; Phillips, P. D.; Richards, G. E.; Skillman, A.; Stephens, K.; Tresillian, N. J.; Wood, N. C.; Wyatt, T. R.

    1995-02-01

    The barrel part of the OPAL muon detector consists of 110 drift chambers forming four layers outside the hadron absorber. Each chamber covers an area of 1.2 m by up to 10.4 m and has two cells with wires parallel to the beam and a drift distance of 297 mm. A detailed description of the design, construction, operation and performance of the sub-detector is given. The system has been operating successfully since the start of LEP in 1989.

  7. Prototyping the PANDA Barrel DIRC

    NASA Astrophysics Data System (ADS)

    Schwarz, C.; Kalicy, G.; Dzhygadlo, R.; Gerhardt, A.; Götzen, K.; Hohler, R.; Kumawat, H.; Lehmann, D.; Lewandowski, B.; Patsyuk, M.; Peters, K.; Schepers, G.; Schmitt, L.; Schwiening, J.; Traxler, M.; Zühlsdorf, M.; Dodokhov, V. Kh.; Britting, A.; Eyrich, W.; Lehmann, A.; Uhlig, F.; Düren, M.; Föhl, K.; Hayrapetyan, A.; Kröck, B.; Merle, O.; Rieke, J.; Cowie, E.; Keri, T.; Montgomery, R.; Rosner, G.; Achenbach, P.; Cardinali, M.; Hoek, M.; Lauth, W.; Sfienti, C.; Thiel, M.; Bühler, P.; Gruber, L.; Marton, J.; Suzuki, K.

    2014-12-01

    The design of the Barrel DIRC detector for the future PANDA experiment at FAIR contains several important improvements compared to the successful BABAR DIRC, such as focusing and fast timing. To test those improvements as well as other design options a prototype was build and successfully tested in 2012 with particle beams at CERN. The prototype comprises a radiator bar, focusing lens, mirror, and a prism shaped expansion volume made of synthetic fused silica. An array of micro-channel plate photomultiplier tubes measures the location and arrival time of the Cherenkov photons with sub-nanosecond resolution. The development of a fast reconstruction algorithm allowed to tune construction details of the detector setup with test beam data and Monte-Carlo simulations.

  8. MISR Level 1A Products

    Atmospheric Science Data Center

    2013-04-01

    ... Data Product Specification Rev D  (PDF). HDF file access efficiency updates. F01_0003 02/16/2001 ... Initial baseline for all Level 1 products available for public release. Baseline Software:  N/A ...

  9. Excitatory neuronal connectivity in the barrel cortex

    PubMed Central

    Feldmeyer, Dirk

    2012-01-01

    Neocortical areas are believed to be organized into vertical modules, the cortical columns, and the horizontal layers 1–6. In the somatosensory barrel cortex these columns are defined by the readily discernible barrel structure in layer 4. Information processing in the neocortex occurs along vertical and horizontal axes, thereby linking individual barrel-related columns via axons running through the different cortical layers of the barrel cortex. Long-range signaling occurs within the neocortical layers but also through axons projecting through the white matter to other neocortical areas and subcortical brain regions. Because of the ease of identification of barrel-related columns, the rodent barrel cortex has become a prototypical system to study the interactions between different neuronal connections within a sensory cortical area and between this area and other cortical as well subcortical regions. Such interactions will be discussed specifically for the feed-forward and feedback loops between the somatosensory and the somatomotor cortices as well as the different thalamic nuclei. In addition, recent advances concerning the morphological characteristics of excitatory neurons and their impact on the synaptic connectivity patterns and signaling properties of neuronal microcircuits in the whisker-related somatosensory cortex will be reviewed. In this context, their relationship between the structural properties of barrel-related columns and their function as a module in vertical synaptic signaling in the whisker-related cortical areas will be discussed. PMID:22798946

  10. CALIFA Barrel prototype detector characterisation

    NASA Astrophysics Data System (ADS)

    Pietras, B.; Gascón, M.; Álvarez-Pol, H.; Bendel, M.; Bloch, T.; Casarejos, E.; Cortina-Gil, D.; Durán, I.; Fiori, E.; Gernhäuser, R.; González, D.; Kröll, T.; Le Bleis, T.; Montes, N.; Nácher, E.; Robles, M.; Perea, A.; Vilán, J. A.; Winkel, M.

    2013-11-01

    Well established in the field of scintillator detection, Caesium Iodide remains at the forefront of scintillators for use in modern calorimeters. Recent developments in photosensor technology have lead to the production of Large Area Avalanche Photo Diodes (LAAPDs), a huge advancement on traditional photosensors in terms of high internal gain, dynamic range, magnetic field insensitivity, high quantum efficiency and fast recovery time. The R3B physics programme has a number of requirements for its calorimeter, one of the most challenging being the dual functionality as both a calorimeter and a spectrometer. This involves the simultaneous detection of ∼300 MeV protons and gamma rays ranging from 0.1 to 20 MeV. This scintillator - photosensor coupling provides an excellent solution in this capacity, in part due to the near perfect match of the LAAPD quantum efficiency peak to the light output wavelength of CsI(Tl). Modern detector development is guided by use of Monte Carlo simulations to predict detector performance, nonetheless it is essential to benchmark these simulations against real data taken with prototype detector arrays. Here follows an account of the performance of two such prototypes representing different polar regions of the Barrel section of the forthcoming CALIFA calorimeter. Measurements were taken for gamma-ray energies up to 15.1 MeV (Maier-Leibnitz Laboratory, Garching, Germany) and for direct irradiation with a 180 MeV proton beam (The Svedberg Laboratoriet, Uppsala, Sweden). Results are discussed in light of complementary GEANT4 simulations.

  11. Master plate production for the tile calorimeter extended barrel modules.

    SciTech Connect

    Guarino, V.J.; Hill, N.; Petereit, E.; Price, L.E.; Proudfoot, J.; Wood, K.

    1999-03-10

    Approximately 41,000 master plates (Fig. 1) are required for the Extended Barrel Hadronic Calorimeter for the ATLAS experiment at the LHC. Early in the R&D program associated with the detector, it was recognized that the fabrication of these steel laminations was a significant issue, both in terms of the cost to produce these high precision formed plates, as well as the length of time required to produce all plates for the calorimeter. Two approaches were given serious consideration: laser cutting and die stamping. The Argonne group was a strong supporter of the latter approach and in late 1995 initiated an R&D program to demonstrate the feasibility and cost effectiveness of die stamping these plates by constructing a die and stamping approximately 2000 plates for use in construction of three full size prototype modules. This was extremely successful and die stamping was selected by the group for production of these plates. When the prototype die was constructed it was matched to the calorimeter envelope at that time. This subsequently changed. However with some minor adjustments in the design envelope and a small compromise in terms of instrumented volume, it became possible to use this same die for the production of all master plates for the Tile Calorimeter. Following an extensive series of discussions and an evaluation of the performance of the stamping presses available to our collaborators in Europe, it was decided to ship the US die to CERN for use in stamping master plates for the barrel section of the calorimeter. This was done under the supervision of CERN and JINR, Dubna, and carried out at the TATRA truck plant at Koprivinice, Czech Republic. It was a great success. Approximately 41,000 plates were stamped and fully met specification. Moreover, the production time was significantly reduced by avoiding the need of constructing and then qualifying a second die for use in Europe. This also precluded small geometrical differences between the barrel and

  12. MISR Level 1A Products

    Atmospheric Science Data Center

    2013-04-01

    ... Data Product Specification Rev D  (PDF). HDF file access efficiency updates. F01_03, F01_0003 ... Initial baseline for all Level 1 products available for public release. Baseline Software:  N/A     ...

  13. MISR Level 1A Products

    Atmospheric Science Data Center

    2013-04-01

    ... Data Product Specification Rev D  (PDF). HDF file access efficiency updates. F01_0004 02/16/2001 ... Initial baseline for all Level 1 products available for public release. Baseline Software:  N/A     ...

  14. Barrel Calorimeter for the Hall D Spectrometer

    SciTech Connect

    David Urner

    1998-06-01

    The barrel calorimeter for the hall D spectrometer is discussed for standard pointing geometry and a parallel geometry using Lead Scintillating fibres as active material. A comparison with a CSI spectrometer is shown.

  15. High performance railgun barrels for laboratory use

    NASA Astrophysics Data System (ADS)

    Bauer, David P.; Newman, Duane C.

    1993-01-01

    High performance low-cost, laboratory railgun barrels are now available, comprised of an inherently stiff containment structure which surrounds the bore components machined from 'off the-shelf' materials. The shape of the containment structure was selected to make the barrel inherently stiff. The structure consists of stainless steel laminations which do not compromise the electrical efficiency of the railgun. The modular design enhances the utility of the barrel, as it is easy to service between shots, and can be 're-cored' to produce different configurations and sizes using the same structure. We have produced barrels ranging from 15 mm to 90 mm square bore, a 30 mm round bore, and in lengths varying from 0.25 meters to 10 meters long. Successful tests with both plasma and solid metal armatures have demonstrated the versatility and performance of this design.

  16. Effects of barrel joints on hypervelocity projectiles

    SciTech Connect

    Shahinpoor, M.; Asay, J.R.; Dixon, W.R.; Hawke, R.S.

    1987-01-01

    Development of new hypervelocity launchers is necessary for equation of state (EOS) studies at high impact velocities. The requirements for barrel joint alignment and concentricity at high velocities place severe constraints on fabrication and assembly procedures; small steps or longitudinal direction changes at joints may cause major damage to precision projectiles. Research has been initiated to identify the technical limits of fabrication and assembly tolerances for hypervelocity gun barrels. Numerical and experimental studies have evaluated projectile performance at velocities of 6 to 15 km/s and have identified failure modes for Lexan projectiles with thin metal facings.

  17. Rain Barrels: A Catalyst for Change?

    ERIC Educational Resources Information Center

    Bakacs, Michele E.; Haberland, Mike; Mangiafico, Salvatore S.; Winquist, Aileen; Obropta, Christopher C.; Boyajian, Amy; Mellor, Sara

    2013-01-01

    Over the past 4 years, rain barrel programming for residents has been implemented in both Northern Virginia and New Jersey as a method for educating the public about stormwater management and water conservation. Program participants demonstrated a significant increase in knowledge of water resource issues. Follow-up surveys showed 58% of New…

  18. Adapting to Pork-Barrel Science.

    ERIC Educational Resources Information Center

    Walsh, John

    1987-01-01

    Discusses the increasing trend toward the pork-barrel funding of science projects, particularly for grants to academic institutions. Addresses the new strategies being employed by opponents of such funding. Describes some of the possible ramifications of the various strategies and the perceived link between science funding and economic growth. (TW)

  19. 15 CFR 241.2 - Legal standard barrels.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... having the dimensions specified for a standard barrel for fruits, vegetables, and other dry commodities... form or dimensions, is a legal standard barrel for fruits, vegetables, or other dry commodities other... having the dimensions specified for a standard barrel for cranberries in section 1 of the...

  20. 49 CFR 178.510 - Standards for wooden barrels.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... follows: (1) The wood used must be of good quality, straight-grained, well-seasoned and free from knots... of the barrel. (3) Staves and heads must be sawn or cleft with the grain so that no annual ring... good quality. The hoops of 2C2 barrels may be of a suitable hardwood. (5) For wooden barrels 2C1,...

  1. Barrel calorimeter of the CMD-3 detector

    NASA Astrophysics Data System (ADS)

    Shebalin, V. E.; Anisenkov, A. V.; Aulchenko, V. M.; Bashtovoy, N. S.; Epifanov, D. A.; Epshteyn, L. B.; Grebenuk, A. A.; Ignatov, F. V.; Erofeev, A. L.; Kovalenko, O. A.; Kozyrev, A. N.; Kuzmin, A. S.; Logashenko, I. B.; Mikhailov, K. Yu.; Razuvaev, G. P.; Ruban, A. A.; Shwartz, B. A.; Talyshev, A. A.; Titov, V. M.; Yudin, Yu. V.

    2015-12-01

    The structure of the barrel calorimeter of the CMD-3 detector is presented in this work. The procedure of energy calibration of the calorimeter and the method of photon energy restoration are described. The distinctive feature of this barrel calorimeter is its combined structure; it is composed of two coaxial subsystems: a liquid xenon calorimeter and a crystalline CsI calorimeter. The calorimeter spatial resolution of the photon conversion point is about 2 mm, which corresponds to an angular resolution of ˜6 mrad. The energy resolution of the calorimeter is about 8% for photons with energy of 200 MeV and 4% for photons with energy of 1 GeV.

  2. Barrel calorimeter of the CMD-3 detector

    SciTech Connect

    Shebalin, V. E. Anisenkov, A. V.; Aulchenko, V. M.; Bashtovoy, N. S.; Epifanov, D. A.; Epshteyn, L. B.; Grebenuk, A. A.; Ignatov, F. V.; Erofeev, A. L.; Kovalenko, O. A.; Kozyrev, A. N.; Kuzmin, A. S.; Logashenko, I. B.; Mikhailov, K. Yu.; Razuvaev, G. P.; Ruban, A. A.; Shwartz, B. A.; Talyshev, A. A.; Titov, V. M.; Yudin, Yu. V.

    2015-12-15

    The structure of the barrel calorimeter of the CMD-3 detector is presented in this work. The procedure of energy calibration of the calorimeter and the method of photon energy restoration are described. The distinctive feature of this barrel calorimeter is its combined structure; it is composed of two coaxial subsystems: a liquid xenon calorimeter and a crystalline CsI calorimeter. The calorimeter spatial resolution of the photon conversion point is about 2 mm, which corresponds to an angular resolution of ∼6 mrad. The energy resolution of the calorimeter is about 8% for photons with energy of 200 MeV and 4% for photons with energy of 1 GeV.

  3. Commissioning of the ATLAS Semiconductor Tracker with cosmic rays

    NASA Astrophysics Data System (ADS)

    Stanecka, E.; Atlas Sct Collaboration

    2007-10-01

    This paper presents the results of the tests with cosmic rays of the ATLAS Semiconductor Tracker (SCT) as well as operational experience of running the fully integrated silicon detector during the commissioning of the completed SCT. Prior to inserting into ATLAS, the barrel part of the SCT has been integrated with the Transition Radiation Tracker (TRT) barrel and tested with cosmic rays. A sector of 468 SCT modules has been powered and read simultaneously with TRT modules in physics mode. In total 500 thousand events were recorded during cosmic runs and processed with the ATLAS off-line reconstruction software. The SCT performance was measured in terms of the average noise occupancy per channel (4.5×10-5) and the overall efficiency (>99%). The tests with cosmic rays proved full functionality of the complex Detector Control System (DCS) which provides control, monitoring and safety functions for the detector electronics.

  4. MISR Level 1 Near Real Time Products

    Atmospheric Science Data Center

    2014-09-15

    Level 1 Near Real Time The MISR Near Real Time Level 1 data products consist of radiance measurements organized in 10-50 minute ... (off-nadir) cameras. The remaining channels are sampled at 1.1 km. ...

  5. CALIOP V4 Level 1 Product Release

    Atmospheric Science Data Center

    2014-11-13

    CALIOP V4 Level 1 Product Release Thursday, November 13, 2014 ...   This updated version of the CALIOP Level 1 data product substantially improves both the 532nm and 1064nm calibration ...   The version 3.x (3.01, 3.02 and 3.30) CALIOP Level 1 data product will continue to be generated and made publically available, ...

  6. X-ray tomography for the ATLAS semi-conductor tracker

    NASA Astrophysics Data System (ADS)

    Doucas, G.; Grosse-Knetter, J.; Nickerson, R.; Vertogradov, L.

    2001-01-01

    Results are presented of precision tests with the prototype of an X-ray tomography system for measuring the two-dimensional position of silicon strip modules on barrel structures. The measured accuracy and repeatability are better than 6 μm in rφ and better than 30 μm in r, where r and φ are polar coordinates, and are sufficient for a high-precision survey of the barrels of the ATLAS semi-conductor tracker.

  7. Design and Performance of the ATLAS Muon Detector Control System

    NASA Astrophysics Data System (ADS)

    Polini, Alessandro; ATLAS Muon Collaboration

    2011-12-01

    Muon detection plays a key role at the Large Hadron Collider. The ATLAS Muon Spectrometer includes Monitored Drift Tubes (MDT) and Cathode Strip Chambers (CSC) for precision momentum measurement in the toroidal magnetic field. Resistive Plate Chambers (RPC) in the barrel region, and Thin Gap Chambers (TGC) in the end-caps, provide the level-1 trigger and a second coordinate used for tracking in conjunction with the MDT. The Detector Control System of each subdetector is required to monitor and safely operate tens of thousand of channels, which are distributed on several subsystems, including low and high voltage power supplies, trigger and front-end electronics, currents and thresholds monitoring, alignment and environmental sensors, gas and electronic infrastructure. The system is also required to provide a level of abstraction for ease of operation as well as expert level actions and detailed analysis of archived data. The hardware architecture and software solutions adopted are shown along with results from the commissioning phase and the routine operation with colliding beams at 3.5 + 3.5 TeV. Design peculiarities of each subsystem and their use to monitor the detector and the accelerator performance are discussed along with the effort for a simple and coherent operation in a running experiment. The material presented can be a base to future test facilities and projects.

  8. Projectile dynamics at low barrel pressures

    NASA Astrophysics Data System (ADS)

    Chankaev, S. K.; Yakovlev, V. Ya.

    2007-11-01

    A mathematical model for a projectile shot at low pressures in the space behind the projectile space is developed. The pressure rise is limited because of the nonsimultaneity of propellant ignition and combustion and the discharge of the propellant combustion products through the gap between the projectile and the walls of the gun barrel. The kinetic characteristics of flame propagation over the propellant particles are determined. A comparison of calculation and experimental data is performed. The calculation results are used in designing 2A85 self-propelled launchers and upgrading 2A30 self-propelled launchers.

  9. Results from the SLD barrel CRID detector

    SciTech Connect

    Abe, K.; Antilogus, P. |; Aston, D.

    1993-11-01

    We report on operational experience with and experimental performance of the SLD barrel Cherenkov Ring Imaging Detector from the 1992 and 1993 physics runs. The liquid (C{sub 6}F{sub 14}) and gas (C{sub 5}F{sub 12}) radiator recirculation systems have performed well, and the drift gas supply system has operated successfully with TMAE for three years. Cherenkov rings have been observed from both the liquid and gas radiators. The number and angular resolution of Cherenkov photons have been measured, and found to be close to design specifications.

  10. Status of the PANDA Barrel DIRC

    NASA Astrophysics Data System (ADS)

    Kalicy, G.; Kumawat, H.; Schwiening, J.; Dzhygadlo, R.; Gerhardt, A.; Hohler, R.; Lehmann, D.; Lewandowski, B.; Patsyuk, M.; Peters, K.; Schepers, G.; Schmitt, L.; Schwarz, C.; Traxler, M.; Zühlsdorf, M.; Dodokhov, V. Kh; Vodopianov, A.; Britting, A.; Eyrich, W.; Lehmann, A.; Uhlig, F.; Düren, M.; Föhl, K.; Hayrapetyan, A.; Koch, P.; Kröck, B.; Merle, O.; Cowie, E.; Keri, T.; Montgomery, R.; Rosner, G.; Seitz, B.; Achenbach, P.; Cardinali, M.; Hoek, M.; Sfienti, C.; Thiel, M.; Ugur, C.; Bühler, P.; Gruber, L.; Marton, J.; Suzuki, K.; Widmann, E.; The PANDA Cherenkov Group

    2014-05-01

    The PANDA experiment at the future Facility for Antiproton and Ion Research in Europe GmbH (FAIR) at GSI, Darmstadt will study fundamental questions of hadron physics and QCD using high-intensity cooled antiproton beams with momenta between 1.5 and 15 GeV/c. Hadronic PID in the barrel region of the PANDA detector will be provided by a DIRC (Detection of Internally Reflected Cherenkov light) counter. The design is based on the successful BABAR DIRC with several key improvements, such as fast photon timing and a compact imaging region. Detailed Monte Carlo simulation studies were performed for DIRC designs based on narrow bars or wide plates with a variety of focusing solutions. The performance of each design was characterized in terms of photon yield and single photon Cherenkov angle resolution and a maximum likelihood approach was used to determine the π/K separation. Selected design options were implemented in prototypes and tested with hadronic particle beams at GSI and CERN. This article describes the status of the design and R&D for the PANDA Barrel DIRC detector, with a focus on the performance of different DIRC designs in simulation and particle beams.

  11. Predicting transmembrane beta-barrels in proteomes

    PubMed Central

    Bigelow, Henry R.; Petrey, Donald S.; Liu, Jinfeng; Przybylski, Dariusz; Rost, Burkhard

    2004-01-01

    Very few methods address the problem of predicting beta-barrel membrane proteins directly from sequence. One reason is that only very few high-resolution structures for transmembrane beta-barrel (TMB) proteins have been determined thus far. Here we introduced the design, statistics and results of a novel profile-based hidden Markov model for the prediction and discrimination of TMBs. The method carefully attempts to avoid over-fitting the sparse experimental data. While our model training and scoring procedures were very similar to a recently published work, the architecture and structure-based labelling were significantly different. In particular, we introduced a new definition of beta- hairpin motifs, explicit state modelling of transmembrane strands, and a log-odds whole-protein discrimination score. The resulting method reached an overall four-state (up-, down-strand, periplasmic-, outer-loop) accuracy as high as 86%. Furthermore, accurately discriminated TMB from non-TMB proteins (45% coverage at 100% accuracy). This high precision enabled the application to 72 entirely sequenced Gram-negative bacteria. We found over 164 previously uncharacterized TMB proteins at high confidence. Database searches did not implicate any of these proteins with membranes. We challenge that the vast majority of our 164 predictions will eventually be verified experimentally. All proteome predictions and the PROFtmb prediction method are available at http://www.rostlab.org/services/PROFtmb/. PMID:15141026

  12. The ATLAS Liquid Argon Calorimeter: Construction, Integration, Commissioning

    SciTech Connect

    Aleksa, Martin

    2006-10-27

    The ATLAS liquid argon (LAr) calorimeter system consists of an electromagnetic barrel calorimeter and two end caps with electromagnetic, hadronic and forward calorimeters. The liquid argon sampling technique, with an accordion geometry was chosen for the barrel electromagnetic calorimeter (EMB) and adapted to the end cap (EMEC). The hadronic end cap calorimeter (HEC) uses a copper-liquid argon sampling technique with flat plate geometry and is subdivided in depth in two wheels per end-cap. Finally, the forward calorimeter (FCAL) is composed of three modules employing cylindrical electrodes with thin liquid argon gaps.The construction of the full calorimeter system is complete since mid-2004. Production modules constructed in the home institutes were integrated into wheels at CERN in 2003-2004, and inserted into the three cryostats. They passed their first complete cold test before the lowering into the ATLAS cavern. Results of quality checks (e.g. electrical, mechanical, ...) performed on all the 190304 read-out channels after cool down will be reported. End 2004 the ATLAS barrel electromagnetic (EM) calorimeter was installed in the ATLAS cavern and since summer 2005 the front-end electronics are being connected and tested. Results of this first commissioning phase will be shown to demonstrate the high standards of quality control for our detectors.

  13. 1. EXTERIOR, SIDE OF PICKLE BARREL RESTAURANT AND ADJOINING STORE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. EXTERIOR, SIDE OF PICKLE BARREL RESTAURANT AND ADJOINING STORE - Silverton Historic District, East Thirteenth & Green Streets (Commercial Building), East Thirteenh & Green Streets, Silverton, San Juan County, CO

  14. Recent results from the Crystal Barrel experiment

    SciTech Connect

    Not Available

    1991-10-09

    The Crystal Barrel experiment has been constructed and installed at the Low Energy Antiproton Ring (LEAR) at CERN. It has been fully operational since late 1989. In this talk, recent results of meson spectroscopy in p[bar p]-annihilations are presented. The main emphasis is on all-neutral annihilations, the study of the strange quark content of the proton, and the investigation of the decay mode of il particles. A 2[sup ++] resonance decaying into [pi][degrees][pi][degrees]at a mass of 1515 [plus minus] 10 MeV with a width of 120 [plus minus] 10 MeV has been seen in a 3[pi][degrees] final state.

  15. Recent results from the Crystal Barrel experiment

    SciTech Connect

    The Crystal Barrel Collaboration

    1991-10-09

    The Crystal Barrel experiment has been constructed and installed at the Low Energy Antiproton Ring (LEAR) at CERN. It has been fully operational since late 1989. In this talk, recent results of meson spectroscopy in p{bar p}-annihilations are presented. The main emphasis is on all-neutral annihilations, the study of the strange quark content of the proton, and the investigation of the decay mode of il particles. A 2{sup ++} resonance decaying into {pi}{degrees}{pi}{degrees}at a mass of 1515 {plus_minus} 10 MeV with a width of 120 {plus_minus} 10 MeV has been seen in a 3{pi}{degrees} final state.

  16. 49 CFR 178.510 - Standards for wooden barrels.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... of the barrel. (3) Staves and heads must be sawn or cleft with the grain so that no annual ring extends over more than half the thickness of a stave or head. (4) Barrel hoops must be of steel or iron...

  17. Planetary atlases

    NASA Technical Reports Server (NTRS)

    Batson, R. M.; Inge, J. L.; Morgan, H. F.

    1991-01-01

    Two kinds of planetary map atlases are in production. Atlases of the first kind contain reduced-scale versions of maps in hard-bound books with dimensions of 11 x 14 inches. These new atlases are intended to: (1) provide concise but comprehensive references to the geography of the planets needed by planetary scientists and others; and (2) allow inexpensive access to the planetary map dataset without requiring acquisition and examination of tens or hundreds of full-size map sheets. Two such atlases have been published and a third is in press. Work was begun of an Atlas of the Satellite of the Outer Planets. The second kind of atlas is a popular or semi-technical version designed for commercial publication and distribution. The first edition, The Atlas of the Solar System, is nearly ready for publication. New funding and contracting constraints now make it unlikely that the atlas can be published in the format originally planned. Currently, the possibility of publishing the maps through the U.S. Geological Survey as a series of folios in the I-map series is being explored. The maps are global views of each solid-surface body of the Solar System. Each map shows airbrushed relief, albedo, and, where available, topography. A set of simplified geologic maps is also included. All of the maps are on equal-area projections. Scales are 1:40,000,000 for the Earth and Venus; 1:2,000,000 for the Saturnian satellites Mimas and Enceladus and the Uranian satellite Miranda; 1:100,000 for the Martian satellites, Phobos and Deimos; and 1:10,000,000 for all other bodies.

  18. The GlueX Barrel Electromagnetic Calorimeter

    NASA Astrophysics Data System (ADS)

    Papandreou, Zisis; Lolos, George; Semenov, Andrei; GlueX Collaboration

    2011-04-01

    The goal of the GLUEX experiment at Jefferson Lab is to search for exotic hybrid mesons as evidence of gluonic excitations, in an effort to understand confinement in QCD. A key subsystem of the GLUEX detector is the electromagnetic barrel calorimeter (BCAL) located inside a 2-Tesla superconducting solenoid. BCAL is a ``spaghetti calorimeter,'' consisting of layers of corrugated lead sheets, interleaved with planes of 1-mm-diameter, double-clad, Kuraray SCSF-78MJ scintillating fibres, bonded in the lead grooves using optical epoxy. The detector will consist of 48 modules and will be readout using nearly 4,000 large-area (1.26 cm2 each) silicon photomultiplier arrays. BCAL construction is well under way at the University of Regina and test results will be shown. Supported by NSERC grant SAPJ-326516, DOE grant DE-FG02-0SER41374 and Jefferson Science Associates, LLC. under U.S. DOE Contract No. DE-AC05-06OR23177.

  19. English as a Second Language. Level 1.

    ERIC Educational Resources Information Center

    Lewandowski, Carol

    This guide is intended for use in a level 1 course in English as a second language that was developed as a component of a workplace literacy program for persons employed in the manufacturing and service industries. The course is structured so that, upon its completion, students will be able to accomplish the following: ask grammatically correct…

  20. Science Curriculum Guide, Levels 1 and 2.

    ERIC Educational Resources Information Center

    Newark School District, DE.

    The first two of four levels in a K-12 science curriculum are outlined. In Level 1 (grades K-2) and Level 2 (grades 3-5), science areas include the study of living things, matter and energy, and solar system and universe. Conveniently listed are page locations for educational and instructional objectives, cross-referenced to science area and coded…

  1. COMPILATION OF LEVEL 1 ENVIRONMENTAL ASSESSMENT DATA

    EPA Science Inventory

    The report gives currently available chemical data from 19 Level 1 environmental assessment studies, compiled in standard format. The data are organized within each study by the analytical technique used to generate them. Inorganic data generated by spark source mass spectroscopy...

  2. 16. CONSTRUCTION PROGRESS PHOTO SHOWING SURPLUS GUN BARREL BEING LOWERED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. CONSTRUCTION PROGRESS PHOTO SHOWING SURPLUS GUN BARREL BEING LOWERED INTO PLACE FOR USE AS PIPE TUNNEL. INEEL PHOTO NUMBER NRTS-59-709. - Idaho National Engineering Laboratory, Old Waste Calcining Facility, Scoville, Butte County, ID

  3. 18. CONSTRUCTION PROGRESS PHOTO SHOWING SURPLUS GUN BARRELS IN PLACE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. CONSTRUCTION PROGRESS PHOTO SHOWING SURPLUS GUN BARRELS IN PLACE TO BE USED AS PIPE TUNNELS. INEEL PHOTO NUMBER NRTS-59-925. - Idaho National Engineering Laboratory, Old Waste Calcining Facility, Scoville, Butte County, ID

  4. 49 CFR 178.510 - Standards for wooden barrels.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PACKAGINGS Non-bulk Performance-Oriented Packaging Standards § 178.510 Standards for wooden barrels. (a) The... the purpose intended. (2) The body and heads must be of a design appropriate to the capacity...

  5. 3. BARREL VIEW, LOOKING DOWN LENGTH OF BRIDGE, SHOWING MAKER'S ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. BARREL VIEW, LOOKING DOWN LENGTH OF BRIDGE, SHOWING MAKER'S PLATE, DECORATIVE SCROLLWORK AND URN FINIALS ON NORTHEAST PORTAL - "Forder" Pratt Through Truss Bridge, Spanning Maumee River at County Route 73, Antwerp, Paulding County, OH

  6. Interior view, barrel vaulted store room opening from the south ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Interior view, barrel vaulted store room opening from the south side of the ground floors central east-west passage (PA-1622-A-51) looking northeast. - U. S. Naval Asylum, Biddle Hall, Gray's Ferry Avenue, Philadelphia, Philadelphia County, PA

  7. 8. VIEW NORTHWEST OF EAST ELEVATION SOUTH BARREL ARCH. NOTE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. VIEW NORTHWEST OF EAST ELEVATION SOUTH BARREL ARCH. NOTE STONE WORK, 1920 CONCRETE REPAIRS, AND STEEL BRACES ADDED BY THE NATIONAL PARK SERVICE CIRCA 1962. - Chesapeake & Ohio Canal, Conococheague Creek Aqueduct, Milepost 99.80, Williamsport, Washington County, MD

  8. 15. STOCKHAM PACKED SMALL FITTINGS IN BARRELS AND, AS EARLY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. STOCKHAM PACKED SMALL FITTINGS IN BARRELS AND, AS EARLY AS 1919, TRANSPORTED THEM IN THEIR OWN PACKARD DELIVERY TRUCKS. - Stockham Pipe & Fittings Company, 4000 Tenth Avenue North, Birmingham, Jefferson County, AL

  9. Effects of core barrel on vessel seismic loadings. [LMFBR

    SciTech Connect

    Ma, D.C.; Gvildys, J.; Chang, Y.W.

    1983-01-01

    Reliability of reactor systems under seismic events is a major concern for the safety of the nuclear power plants. This paper deals with the effects of the core barrel on the seismic response of reactor tanks. The main emphases are the effects of core barrel on the free-surface wave height and the fluid coupling effects between the core barrel and primary tank. This study represents an initial step to investigate the effects of in-tank components, structures on the seismically-induced hydrodynamic behavior of the reactor tanks. To simplify the analysis, the tank used in the study is simulated by a two-dimensional model. Two parametric studies were carried out in which the wall flexibility and location of core barrel were used as parameters respectively.

  10. Finite element analysis of the SDC barrel and endcap calorimeters

    SciTech Connect

    Guarino, V.; Hill, N.; Nasiakta, J.

    1992-03-11

    In designing the SCD barrel and endcap calorimeters, the inter-module connecting forces must be known in order to determine the required size and number of connecting links between modules, and in order to understand how individual modules will be affected by these forces when assembled to form a full barrel and endcap. The connecting forces were found by analyzing three-dimensional Finite Element Models of both the barrel and endcap. This paper is divided into two parts, the first part will describe in detail the results of the barrel analysis and the second part will describe the results obtained from the endcap analysis. A similar approach was used in constructing the models for both analysis.

  11. Barrel view from southwest. Waterville Bridge, Spanning Swatara Creek ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Barrel view from southwest. - Waterville Bridge, Spanning Swatara Creek at Appalachian Trail (moved from Little Pine Creek at State Route 44, Waterville, Lycoming County), Green Point, Lebanon County, PA

  12. Barrel view from center span, looking east. Waterville Bridge, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Barrel view from center span, looking east. - Waterville Bridge, Spanning Swatara Creek at Appalachian Trail (moved from Little Pine Creek at State Route 44, Waterville, Lycoming County), Green Point, Lebanon County, PA

  13. Neonatal lead exposure impairs development of rodent barrel field cortex

    PubMed Central

    Wilson, Mary Ann; Johnston, Michael V.; Goldstein, Gary W.; Blue, Mary E.

    2000-01-01

    Childhood exposure to low-level lead can permanently reduce intelligence, but the neurobiologic mechanism for this effect is unknown. We examined the impact of lead exposure on the development of cortical columns, using the rodent barrel field as a model. In all areas of mammalian neocortex, cortical columns constitute a fundamental structural unit subserving information processing. Barrel field cortex contains columnar processing units with distinct clusters of layer IV neurons that receive sensory input from individual whiskers. In this study, rat pups were exposed to 0, 0.2, 1, 1.5, or 2 g/liter lead acetate in their dam's drinking water from birth through postnatal day 10. This treatment, which coincides with the development of segregated columns in the barrel field, produced blood lead concentrations from 1 to 31 μg/dl. On postnatal day 10, the area of the barrel field and of individual barrels was measured. A dose-related reduction in barrel field area was observed (Pearson correlation = −0.740; P < 0.001); mean barrel field area in the highest exposure group was decreased 12% versus controls. Individual barrels in the physiologically more active caudoventral group were affected preferentially. Total cortical area measured in the same sections was not altered significantly by lead exposure. These data support the hypothesis that lead exposure may impair the development of columnar processing units in immature neocortex. We demonstrate that low levels of blood lead, in the range seen in many impoverished inner-city children, cause structural alterations in a neocortical somatosensory map. PMID:10805810

  14. BTeV level 1 vertex trigger

    SciTech Connect

    Michael H.L.S. Wang

    2001-11-05

    BTeV is a B-physics experiment that expects to begin collecting data at the C0 interaction region of the Fermilab Tevatron in the year 2006. Its primary goal is to achieve unprecedented levels of sensitivity in the study of CP violation, mixing, and rare decays in b and c quark systems. In order to realize this, it will employ a state-of-the-art first-level vertex trigger (Level 1) that will look at every beam crossing to identify detached secondary vertices that provide evidence for heavy quark decays. This talk will briefly describe the BTeV detector and trigger, focus on the software and hardware aspects of the Level 1 vertex trigger, and describe work currently being done in these areas.

  15. Level 1 Daq System for Kloe

    NASA Astrophysics Data System (ADS)

    Aloisio, A.; Cavaliere, S.; Cevenini, F.; Della Volpe, D.; Merola, L.; Anastasio, A.; Fiore, D. J.

    KLOE is a general purpose detector optimized to observe CP violation in K0 decays. This detector will be installed at the DAΦNE Φ-factory, in Frascati (Italy) and it is expected to run at the end of 1997. The KLOE DAQ system can be divided mainly into the front-end fast readout section (the Level 1 DAQ), the FDDI Switch and the processor farm. The total bandwidth requirement is estimated to be of the order of 50 Mbyte/s. In this paper, we describe the Level 1 DAQ section, which is based on custom protocols and hardware controllers, developed to achieve high data transfer rates and event building capabilities without software overhead.

  16. Composting barrel for sustainable organic waste management in Bangladesh.

    PubMed

    Moqsud, Md Azizul; Bushra, Quazi Sifat; Rahman, M H

    2011-12-01

    To ensure quick and uniform aerobic stabilization of biowaste through domestic composting and to prevent malodorous emissions, two modifications were made to a conventional steel barrel composter by: (1) providing 0.0125 m diameter openings throughout the sides and (2) placing a 0.0254 m diameter perforated polyvinyl chloride (PVC) pipe in the middle portion of the barrel. The volume of composting waste before modification of the composting barrel was 40% of the original volume and it was 70%, 4 weeks following the modifications. In addition, the nutrients in the compost were found to be in a more suitable range after modification of the composting barrel. The carbon-nitrogen ratio (C/N) of the compost was in the ideal range of 11-15 in the modified composting reactor but it was quite high (24-25) in the conventional barrel. This modified barrel composting plant proved to be an efficient, eco-friendly, cost-effective solution for the management of organic solid waste materials in developing and technologically less sophisticated countries such as Bangladesh. PMID:20870692

  17. Sodium Dichromate Barrel Landfill expedited response action proposal

    SciTech Connect

    Not Available

    1993-09-01

    The US Environmental Protection Agency (EPA) and Washington State Department of Ecology (Ecology) recommended that the US Department of Energy (DOE) prepare an expedited response action (ERA) for the Sodium Dichromate Barrel Landfill. The Sodium Dichromate Barrel Disposal Site was used in 1945 for disposal of crushed barrels. The site location is the sole waste site within the 100-IU-4 Operable Unit. The Waste Information Data System (WIDS 1992) assumes that the crushed barrels contained 1% residual sodium dichromate at burial time and that only buried crushed barrels are at the site. Burial depth is shallow since visual inspection finds numerous barrel debris on the surface. A non-time-critical ERA proposal includes preparation of an engineering evaluation and cost analysis (EE/CA) section. The EE/CA is a rapid, focused evaluation of available technologies using specific screening factors to assess feasibility, appropriateness, and cost. The ERA goal is to reduce the potential for any contaminant migration from the landfill to the soil column, groundwater, and Columbia River. Since the landfill is the only waste site within the operable unit, the ERA will present a final remediation of the 100-IU-4 operable unit.

  18. ESA Swarm Mission - Level 1b Products

    NASA Astrophysics Data System (ADS)

    Tøffner-Clausen, Lars; Floberghagen, Rune; Mecozzi, Riccardo; Menard, Yvon

    2014-05-01

    Swarm, a three-satellite constellation to study the dynamics of the Earth's magnetic field and its interactions with the Earth system, has been launched in November 2013. The objective of the Swarm mission is to provide the best ever survey of the geomagnetic field and its temporal evolution, which will bring new insights into the Earth system by improving our understanding of the Earth's interior and environment. The Level 1b Products of the Swarm mission contain time-series of the quality screened, calibrated, corrected, and fully geo-localized measurements of the magnetic field intensity, the magnetic field vector (provided in both instrument and Earth-fixed frames), the plasma density, temperature, and velocity. Additionally, quality screened and pre-calibrated measurements of the nongravitational accelerations are provided. Geo-localization is performed by 24- channel GPS receivers and by means of unique, three head Advanced Stellar Compasses for high-precision satellite attitude information. The Swarm Level 1b data will be provided in daily products separately for each of the three Swarm spacecrafts. This poster will present detailed lists of the contents of the Swarm Level 1b Products and brief descriptions of the processing algorithms used in the generation of these data.

  19. DAQ hardware and software development for the ATLAS Pixel Detector

    NASA Astrophysics Data System (ADS)

    Stramaglia, Maria Elena

    2016-07-01

    In 2014, the Pixel Detector of the ATLAS experiment has been extended by about 12 million pixels thanks to the installation of the Insertable B-Layer (IBL). Data-taking and tuning procedures have been implemented along with newly designed readout hardware to support high bandwidth for data readout and calibration. The hardware is supported by an embedded software stack running on the readout boards. The same boards will be used to upgrade the readout bandwidth for the two outermost barrel layers of the ATLAS Pixel Detector. We present the IBL readout hardware and the supporting software architecture used to calibrate and operate the 4-layer ATLAS Pixel Detector. We discuss the technical implementations and status for data taking, validation of the DAQ system in recent cosmic ray data taking, in-situ calibrations, and results from additional tests in preparation for Run 2 at the LHC.

  20. Processing TES Level-1B Data

    NASA Technical Reports Server (NTRS)

    DeBaca, Richard C.; Sarkissian, Edwin; Madatyan, Mariyetta; Shepard, Douglas; Gluck, Scott; Apolinski, Mark; McDuffie, James; Tremblay, Dennis

    2006-01-01

    TES L1B Subsystem is a computer program that performs several functions for the Tropospheric Emission Spectrometer (TES). The term "L1B" (an abbreviation of "level 1B"), refers to data, specific to the TES, on radiometric calibrated spectral radiances and their corresponding noise equivalent spectral radiances (NESRs), plus ancillary geolocation, quality, and engineering data. The functions performed by TES L1B Subsystem include shear analysis, monitoring of signal levels, detection of ice build-up, and phase correction and radiometric and spectral calibration of TES target data. Also, the program computes NESRs for target spectra, writes scientific TES level-1B data to hierarchical- data-format (HDF) files for public distribution, computes brightness temperatures, and quantifies interpixel signal variability for the purpose of first-order cloud and heterogeneous land screening by the level-2 software summarized in the immediately following article. This program uses an in-house-developed algorithm, called "NUSRT," to correct instrument line-shape factors.

  1. The structure of the β-barrel assembly machinery complex

    PubMed Central

    Bakelar, Jeremy; Buchanan, Susan K.; Noinaj, Nicholas

    2016-01-01

    β-barrel outer membrane proteins (OMPs) are found within the outer membranes (OM) of Gram-negative bacteria and are essential for nutrient import, signaling, and adhesion. While the exact mechanism is unknown, a 200 kDa five component complex called the β-barrel assembly machinery (BAM) complex has been implicated in the biogenesis of OMPs. Here, we report the structure of the BAM complex from E. coli, revealing that binding of the accessory proteins BamCDE modulates the conformation of BamA, the central component of the complex, which may regulate the function of the BAM complex. The periplasmic domain of BamA was found in a closed state that prevents access to the barrel lumen from the periplasm, indicating substrate OMPs likely do not enter the barrel during biogenesis. Further, the first eight strands of the β-barrel domain undergo an unprecedented conformational shift leading to opening of the exit pore and rearrangement at the lateral gate. PMID:26744406

  2. Aroma potential of oak battens prepared from decommissioned oak barrels.

    PubMed

    Li, Sijing; Crump, Anna M; Grbin, Paul R; Cozzolino, Daniel; Warren, Peter; Hayasaka, Yoji; Wilkinson, Kerry L

    2015-04-01

    During barrel maturation, volatile compounds are extracted from oak wood and impart aroma and flavor to wine, enhancing its character and complexity. However, barrels contain a finite pool of extractable material, which diminishes with time. As a consequence, most barrels are decommissioned after 5 or 6 years. This study investigated whether or not decommissioned barrels can be "reclaimed" and utilized as a previously untapped source of quality oak for wine maturation. Oak battens were prepared from staves of decommissioned French and American oak barrels, and their composition analyzed before and after toasting. The oak lactone glycoconjugate content of untoasted reclaimed oak was determined by liquid chromatography-tandem mass spectrometry, while the concentrations of cis- and trans-oak lactone, guaiacol, 4-methlyguaiacol, vanillin, eugenol, furfural, and 5-methylfurfural present in toasted reclaimed oak were determined by gas chromatography-mass spectrometry. Aroma potential was then evaluated by comparing the composition of reclaimed oak with that of new oak. Comparable levels of oak lactone glycoconjugates and oak volatiles were observed, demonstrating the aroma potential of reclaimed oak and therefore its suitability as a raw material for alternative oak products, i.e., chips or battens, for the maturation of wine. The temperature profiles achieved during toasting were also measured to evaluate the viability of any yeast or bacteria present in reclaimed oak. PMID:25771908

  3. Cortical barrel field ablation and unconditioned whisking kinematics.

    PubMed

    Harvey, M A; Sachdev, R N; Zeigler, H P

    2001-01-01

    The effects of "barrel cortex" ablation upon the biometrics of "exploratory" whisking were examined in three head-fixed rats which had previously sustained unilateral ablation of the left cortical "barrel field" under electrophysiological control. Unconditioned movements of a pair of bilaterally homologous whiskers (C-1, Right, Left) were monitored, optoelectronically, with other whiskers present. Whisking movements on the intact and ablated side were analyzed with respect to kinematics (protraction amplitude and velocity) whisking frequency and phase relationships between whisking movement on the two sides of the face. Histological analysis confirmed complete removal of S-1 "barrel cortex". In normal animals whisking movements have a characteristic rhythm (6-9 Hz), and protractions on the two sides of the face tend to be both synchronous and of very similar amplitudes. In the lesioned animals, whisking frequency was unchanged and whisking movements remained bilaterally synchronous. However, there was a significant difference between the amplitude of Right and Left whisker movements which was evident many months postoperatively. Our results suggest that the deficits in vibrissa-mediated tactile discrimination reported after "barrel" field ablation may reflect an impairment in the animal's ability to modulate whisking parameters on the two sides of the face to meet the functional requirements of a discriminative whisking task. The effects upon whisking amplitude seen after unilateral barrel field ablation are consistent with a model in which the activity of a whisking Central Pattern Generator is modulated by descending inputs to achieve sensorimotor control of whisking movement parameters. PMID:11562085

  4. Treatment Method for Fermi Barrel Sodium Metal Residues

    SciTech Connect

    Steven R. Sherman; Collin J. Knight

    2005-06-01

    Fermi barrels are 55-gallon drums that once contained bulk sodium metal from the shutdown Fermi 1 breeder reactor facility, and now contain residual sodium metal and other sodium/air reaction products. This report provides a residual sodium treatment method and proposed quality assurance steps that will ensure that all residual sodium is deactivated and removed from the Fermi barrels before disposal. The treatment method is the application of humidified carbon dioxide to the residual sodium followed by a water wash. The experimental application of the treatment method to six Fermi barrels is discussed, and recommendations are provided for further testing and evaluation of the method. Though more testing would allow for a greater refinement of the treatment technique, enough data has been gathered from the tests already performed to prove that 100% compliance with stated waste criteria can be achieved.

  5. Neural coding in barrel cortex during whisker-guided locomotion.

    PubMed

    Sofroniew, Nicholas James; Vlasov, Yurii A; Andrew Hires, Samuel; Freeman, Jeremy; Svoboda, Karel

    2015-01-01

    Animals seek out relevant information by moving through a dynamic world, but sensory systems are usually studied under highly constrained and passive conditions that may not probe important dimensions of the neural code. Here, we explored neural coding in the barrel cortex of head-fixed mice that tracked walls with their whiskers in tactile virtual reality. Optogenetic manipulations revealed that barrel cortex plays a role in wall-tracking. Closed-loop optogenetic control of layer 4 neurons can substitute for whisker-object contact to guide behavior resembling wall tracking. We measured neural activity using two-photon calcium imaging and extracellular recordings. Neurons were tuned to the distance between the animal snout and the contralateral wall, with monotonic, unimodal, and multimodal tuning curves. This rich representation of object location in the barrel cortex could not be predicted based on simple stimulus-response relationships involving individual whiskers and likely emerges within cortical circuits. PMID:26701910

  6. Small arms mini-fire control system: fiber-optic barrel deflection sensor

    SciTech Connect

    Rajic, Slobodan; Datskos, Panos G

    2012-01-01

    Traditionally the methods to increase firearms accuracy, particularly at distance, have concentrated on barrel isolation (free floating) and substantial barrel wall thickening to gain rigidity. This barrel stiffening technique did not completely eliminate barrel movement but the problem was significantly reduced to allow a noticeable accuracy enhancement. This process, although highly successful, came at a very high weight penalty. Obviously the goal would be to lighten the barrel (firearm), yet achieve even greater accuracy. Thus, if lightweight barrels could ultimately be compensated for both their static and dynamic mechanical perturbations, the result would be very accurate, yet significantly lighter weight, weapons. We discuss our development of a barrel reference sensor system that is designed to accomplish this ambitious goal. Our optical fiber-based sensor monitors the barrel muzzle position and autonomously compensates for any induced perturbations. The reticle is electronically adjusted in position to compensate for the induced barrel deviation in real time.

  7. Small arms mini-fire control system: fiber-optic barrel deflection sensor

    NASA Astrophysics Data System (ADS)

    Rajic, S.; Datskos, P.; Lawrence, W.; Marlar, T.; Quinton, B.

    2012-06-01

    Traditionally the methods to increase firearms accuracy, particularly at distance, have concentrated on barrel isolation (free floating) and substantial barrel wall thickening to gain rigidity. This barrel stiffening technique did not completely eliminate barrel movement but the problem was significantly reduced to allow a noticeable accuracy enhancement. This process, although highly successful, came at a very high weight penalty. Obviously the goal would be to lighten the barrel (firearm), yet achieve even greater accuracy. Thus, if lightweight barrels could ultimately be compensated for both their static and dynamic mechanical perturbations, the result would be very accurate, yet significantly lighter weight, weapons. We discuss our development of a barrel reference sensor system that is designed to accomplish this ambitious goal. Our optical fiber-based sensor monitors the barrel muzzle position and autonomously compensates for any induced perturbations. The reticle is electronically adjusted in position to compensate for the induced barrel deviation in real time.

  8. VIEW, LOOKING SOUTHWEST OF GOLD AMALGAMATION ROOM, SHOWING AMALGAMATION BARREL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW, LOOKING SOUTHWEST OF GOLD AMALGAMATION ROOM, SHOWING AMALGAMATION BARREL AT CENTER FOREGROUND, BULLION FURNACE IN LARGE HOOD BEHIND IT, AND GOLD RETORT IN BACKGROUND HOOD. NOTE OVERHEAD MONORAIL FOR MATERIALS HANDLING. - Shenandoah-Dives Mill, 135 County Road 2, Silverton, San Juan County, CO

  9. 8. Generator Barrel and Shaft of Unit 1, view to ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Generator Barrel and Shaft of Unit 1, view to the northwest, with turbine shaft and thrust bearing visible in upper center of photograph. - Washington Water Power Clark Fork River Noxon Rapids Hydroelectric Development, Powerhouse, South bank of Clark Fork River at Noxon Rapids, Noxon, Sanders County, MT

  10. 14. Interior view, grain tanks (bins). Barrel view of tunnel ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. Interior view, grain tanks (bins). Barrel view of tunnel for load-out belt conveyor system located below tanks. Square, numbered spouts gravity-feed grain from overhead bins onto belt. - Saint Anthony Elevator No. 3, 620 Malcom Avenue, Southeast, Minneapolis, Hennepin County, MN

  11. 4. AERIAL 'BARREL' SHOT OF THE PATH TRANSIT SYSTEM BRIDGE, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. AERIAL 'BARREL' SHOT OF THE PATH TRANSIT SYSTEM BRIDGE, LOOKING SOUTHEAST TOWARDS JERSEY CITY. TO THE RIGHT ARE THE NEWARK TURNPIKE AND THE CONRAIL BRIDGE (HAER No. NJ-43). THE PULASKI SKYWAY (HAER No. NJ-34) IS IN THE BACKGROUND TO THE RIGHT - Path Transit System Bridge, Spanning Hackensack River, Kearny, Hudson County, NJ

  12. A 'barrel shot' looking down the track and through the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    A 'barrel shot' looking down the track and through the 114'- 8-1/2' south thru truss approach span, showing pole line supported across top of steal superstructure. The 364' - 0-1/4' swing span over river has been used by various Railroads for a period of 90 years. - Bridgeport Swing Span Bridge, Spanning Tennessee River, Bridgeport, Jackson County, AL

  13. Science Highlights from the BARREL Antarctic Balloon Campaigns

    NASA Astrophysics Data System (ADS)

    Millan, R. M.; Sample, J. G.; McCarthy, M.; Smith, D. M.

    2014-12-01

    The Balloon Array for Radiation belt Relativistic Electron Losses (BARREL) is an Antarctic balloon investigation designed to study electron loss from Earth's radiation belts. Two BARREL balloon campaigns were carried out from Antarctic Research Stations SANAE IV and Halley VI in January-February 2013 and 2014. During each campaign, 20 small (~20 kg) balloon payloads were launched to an altitude of 38 km to maintain an array of payloads distributed in L-value and magnetic local time. Each balloon carried a NaI scintillator to measure the bremsstrahlung X-rays produced by precipitating relativistic electrons as they collide with neutrals in Earth's atmosphere, and a DC magnetometer to explore the nature of Ultra Low Frequency temporal modulations of precipitation. We present several science highlights from BARREL. Precipitation was observed over a range of energies with temporal and spatial structure at a variety of scales. The combination of BARREL with in situ (e.g. Van Allen Probes, THEMIS) and ground-based (e.g. riometer, VLF) measurements provides a unique opportunity to study wave-particle interactions, and to quantify the spatial scale of energetic precipitation.

  14. New results in meson spectroscopy from the crystal barrel experiment

    SciTech Connect

    Meyer, C.A.

    1994-04-01

    Recent observations by the Crystal Barrel experiment of two scalar resonances, f{sub o}(1365) and a{sub o}(1450) have allowed the authors to clarify the members of the scalar nonet. In addition, a third scalar, f{sub o}(1500), appears to be supernumerary, and is a candidate for the scalar glueball expected near 1500 MeV.

  15. [Death after explosion of an "empty" acetone barrel].

    PubMed

    Preuss-Wössner, Johanna; Gerling, Ivana

    2013-01-01

    Inappropriate disposal of (hazardous) waste material led to an explosion of an acetone-air mixture in a metal barrel. The lid was blown off and caused blunt traumatization with fatal exsanguination. The case furnishes information relevant for the practical teaching of forensic knowledge and the indicated consultation of medico-legal experts already at scene. PMID:24358622

  16. 27 CFR 25.144 - Rebranding barrels and kegs.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL BEER Marks, Brands, and Labels § 25.144 Rebranding barrels and... permanently remove or durably cover the original marks and brands after notifying the appropriate TTB officer... the original marks and brands if the brewer: (1) Adopts a trade name substantially identical to...

  17. 1. INTERIOR VIEW WITH NAVE, BARREL VAULTED SOLEA, ICONOSTAS WITH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. INTERIOR VIEW WITH NAVE, BARREL VAULTED SOLEA, ICONOSTAS WITH ICON AND SANCTUARY. IN ARCH ABOVE THE SANCTUARY IS THE TABLE OF ABRAHAM. THE ICONOSTAS INCLUDES ICONS OF THE ARCHANGEL MICHAEL, THE HOLY TRINITY, MOTHER OF GOD HOLDING THE CHRIST CHILD, JESUS. - Holy Trinity-Holy Cross Greek Orthodox Church, 200 Nineteenth Street South, Birmingham, Jefferson County, AL

  18. 27 CFR 25.144 - Rebranding barrels and kegs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Marks, Brands, and Labels § 25.144 Rebranding barrels and... permanently remove or durably cover the original marks and brands after notifying the appropriate TTB officer... the original marks and brands if the brewer: (1) Adopts a trade name substantially identical to...

  19. 27 CFR 25.144 - Rebranding barrels and kegs.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Marks, Brands, and Labels § 25.144 Rebranding barrels and... permanently remove or durably cover the original marks and brands after notifying the appropriate TTB officer... the original marks and brands if the brewer: (1) Adopts a trade name substantially identical to...

  20. 9. Generator Barrel and Rotor of Unit 1, view to ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Generator Barrel and Rotor of Unit 1, view to the southeast, showing part of the rotor and generator coils along top of photograph and southeast entry stairwell and doors in lower center of photograph. - Washington Water Power Clark Fork River Noxon Rapids Hydroelectric Development, Powerhouse, South bank of Clark Fork River at Noxon Rapids, Noxon, Sanders County, MT

  1. Mouse barrel cortex functionally compensates for deprivation produced by neonatal lesion of whisker follicles.

    PubMed

    Melzer, P; Crane, A M; Smith, C B

    1993-12-01

    In the murine somatosensory pathway, the metabolic whisker map in barrel cortex derived with the autoradiographic deoxyglucose method is spatially in register with the morphological whisker map represented by the barrels. The barrel cortex of adult mice, in which we had removed three whisker follicles from the middle row of whiskers shortly after birth, contained a disorganized zone surrounded by enlarged barrels with partially disrupted borders. With the fully quantitative autoradiographic deoxyglucose method, we investigated in barrel cortex of such mice the magnitude and the pattern of metabolic responses evoked by the deflection of whiskers. Most remarkably, the simultaneous deflection of six whiskers neighbouring the lesion activated not only the territory of the corresponding barrels, but also the unspecifiable area intercalated between the clearly identified barrels. This metabolic whisker map, unpredictable from the morphological 'barrel' map, may reflect a functional compensation for the deficit in input. PMID:8124517

  2. Simulation and reconstruction of the PANDA Barrel DIRC

    NASA Astrophysics Data System (ADS)

    Dzhygadlo, R.; Gerhardt, A.; Go¨tzen, K.; Hohler, R.; Kalicy, G.; Kumawat, H.; Lehmann, D.; Lewandowski, B.; Patsyuk, M.; Peters, K.; Schepers, G.; Schmitt, L.; Schwarz, C.; Schwiening, J.; Traxler, M.; Zühlsdorf, M.; Dodokhov, V. Kh.; Britting, A.; Eyrich, W.; Lehmann, A.; Uhlig, F.; Düren, M.; Fo¨hl, K.; Hayrapetyan, A.; Kro¨ck, B.; Merle, O.; Rieke, J.; Cowie, E.; Keri, T.; Montgomery, R.; Rosner, G.; Achenbach, P.; Cardinali, M.; Hoek, M.; Lauth, W.; Sfienti, C.; Thiel, M.; Bühler, P.; Gruber, L.; Marton, J.; Suzuki, K.

    2014-12-01

    Hadronic particle identification (PID) in the barrel region of the PANDA experiment at the new Facility for Antiproton and Ion Research in Europe (FAIR) at GSI, Darmstadt will be provided by a DIRC (Detection of Internally Reflected Cherenkov light) counter. To optimize the performance and reduce the detector cost, detailed simulations of different design elements, such as the width of the radiators, the shape of the expansion volume, and the type of focusing system, were performed using Geant. Custom reconstruction algorithms were developed to match the detector geometry. We will discuss the single photon resolution and photon yield as well as the PID performance for the Barrel DIRC baseline design and several detector design options.

  3. Scanning and Measuring Device for Diagnostic of Barrel Bore

    NASA Astrophysics Data System (ADS)

    Marvan, Ales; Hajek, Josef; Vana, Jan; Dvorak, Radim; Drahansky, Martin; Jankovych, Robert; Skvarek, Jozef

    The article discusses the design, mechanical design, electronics and software for robot diagnosis of barrels with caliber of 120 mm to 155 mm. This diagnostic device is intended primarily for experimental research and verification of appropriate methods and technologies for the diagnosis of the main bore guns. Article also discusses the design of sensors and software, the issue of data processing and image reconstruction obtained by scanning of the surface of the bore.

  4. Barrels XXVIII take the Windy City by storm.

    PubMed

    Gour, Anjali; Lyall, Evan H; Naka, Alexander; Brumberg, Joshua C

    2016-03-01

    The 28th annual Barrels meeting was held prior to the Society for Neuroscience meeting in October 2015 at the Northwestern University School of Law in Chicago, Illinois. The meeting brought together researchers focused on the rodent sensorimotor system. The meeting focused on modern techniques to decipher cortical circuits, social interactions among rodents, and decision-making. The meeting allowed investigators to share their work via short talks, poster presentations, and a data blitz. PMID:27121988

  5. NASA Marshall Space Flight Center Barrel-Shaped Asymmetrical Capacitor

    NASA Technical Reports Server (NTRS)

    Campbell, J. W.; Carruth, M. R.; Edwards, D. L.; Finchum, A.; Maxwell, G.; Nabors, S.; Smalley, L.; Huston, D.; Ila, D.; Zimmerman, R.

    2004-01-01

    The NASA Barrel-Shaped Asymmetrical Capacitor (NACAP) has been extensively tested at NASA Marshall Space Flight Center and the National Space Science and Technology Center. Trichel pulse emission was first discovered here. The NACAP is a magnetohydrodynamic device for electric propulsion. In air it requires no onboard propellant nor any moving parts. No performance was observed in hard vacuum. The next step shall be optimizing the technology for future applications.

  6. Comparative study of WLS fibres for the ATLAS Tile Calorimeter

    NASA Astrophysics Data System (ADS)

    Gomes, A.; David, M.; Henriques, A.; Maio, A.

    1998-02-01

    The Wave Length Shifting (WLS) fibres are one of the most important components of the ATLAS barrel hadronic tile calorimeter (Tilecal). The fibres collect the hght produced in the injection molded scintillating tiles and transport it to the photomultipliers. Parameters like attenuation length and light yield are important, as well as flexibility and radiation hardness. Comparative results of WLS fibres produced by Bicron, Kuraray and Pol.Hi.Tech are presented. The performance of the fibres BCF91A from Bicron and S048 from Pol.Hi.Tech was significatively improved, but the most performant are still the double clad Y11 fibres from Kuraray.

  7. Comparative study of WLS fibres for the ATLAS tile calorimeter

    NASA Astrophysics Data System (ADS)

    Gomes, A.; David, M.; Henriques, A.; Maio, A.

    1997-02-01

    The Wave Length Shifting (WLS) fibres are one of the most important components of the ATLAS barrel hadronic tile calorimeter (Tilecal). The fibres collect the light produced in the injection molded scintillating tiles and transport it to the photomultipliers. Parameters like attenuation length and light yield are important, as well as flexibility and radiation hardness. Comparative results of WLS fibres produced by Bicron, Kuraray and Pol.Hi.Tech are presented. The performance of the fibres BCF91A from Bicron and S048 from Pol.Hi.Tech was significatively improved, but the most performant are still the double clad Y11 fibres from Kuraray.

  8. Cesium monitoring system for ATLAS Tile Hadron Calorimeter

    NASA Astrophysics Data System (ADS)

    Starchenko, E.; Blanchot, G.; Bosman, M.; Cavalli-Sforza, M.; Karyukhin, A.; Kopikov, S.; Miagkov, A.; Nessi, M.; Shalimov, A.; Shalanda, N.; Soldatov, M.; Solodkov, A.; Soloviev, A.; Tsoupko-Sitnikov, V.; Zaitsev, A.

    2002-11-01

    A system to calibrate and monitor ATLAS Barrel Hadronic Calorimeter (TileCal) is under construction at CERN Laboratory. A movable radioactive source driven by a liquid flow travels through the calorimeter body deposing a known energy to the calorimeter cells. Extensive R&D studies have been carried out and the main system parameters are evaluated. The prototypes are currently used for quality check and inter-calibration of the TileCal modules. A distributed control system, hardware as well as corresponding on-line and off-line software is developed.

  9. Long-Term Synaptic Plasticity in Rat Barrel Cortex.

    PubMed

    Han, Yong; Huang, Ming-De; Sun, Man-Li; Duan, Shumin; Yu, Yan-Qin

    2015-09-01

    Rats generate sweeping whisker movements in order to explore their environments and identify objects. In somatosensory pathways, neuronal activity is modulated by the frequency of whisker vibration. However, the potential role of rhythmic neuronal activity in the cerebral processing of sensory signals and its mechanism remain unclear. Here, we showed that rhythmic vibrissal stimulation with short duration in anesthetized rats resulted in an increase or decrease in the amplitude of somatosensory-evoked potentials (SEPs) in the contralateral barrel cortex. The plastic change of the SEPs was frequency dependent and long lasting. The long-lasting enhancement of the vibrissa-to-cortex evoked response was side- but not barrel-specific. Local application of dl-2-amino-5-phosphonopentanoic acid into the barrel cortex revealed that this vibrissa-to-cortex long-term plasticity in adult rats was N-methyl-d-aspartate receptor-dependent. Most interestingly, whisker trimming through postnatal day (P)1-7 but not P29-35 impaired the long-term plasticity induced by 100 Hz vibrissal stimulation. The short period of rhythmic vibrissal stimulation did not induce long-lasting plasticity of field potentials in the thalamus. In conclusion, our results suggest that natural rhythmic whisker activity modifies sensory information processing in cerebral cortex, providing further insight into sensory perception. PMID:24735674

  10. Neural coding in barrel cortex during whisker-guided locomotion

    PubMed Central

    Sofroniew, Nicholas James; Vlasov, Yurii A; Andrew Hires, Samuel; Freeman, Jeremy; Svoboda, Karel

    2015-01-01

    Animals seek out relevant information by moving through a dynamic world, but sensory systems are usually studied under highly constrained and passive conditions that may not probe important dimensions of the neural code. Here, we explored neural coding in the barrel cortex of head-fixed mice that tracked walls with their whiskers in tactile virtual reality. Optogenetic manipulations revealed that barrel cortex plays a role in wall-tracking. Closed-loop optogenetic control of layer 4 neurons can substitute for whisker-object contact to guide behavior resembling wall tracking. We measured neural activity using two-photon calcium imaging and extracellular recordings. Neurons were tuned to the distance between the animal snout and the contralateral wall, with monotonic, unimodal, and multimodal tuning curves. This rich representation of object location in the barrel cortex could not be predicted based on simple stimulus-response relationships involving individual whiskers and likely emerges within cortical circuits. DOI: http://dx.doi.org/10.7554/eLife.12559.001 PMID:26701910

  11. Rapid, learning-induced inhibitory synaptogenesis in murine barrel field

    PubMed Central

    Jasinska, M.; Siucinska, E.; Cybulska-Klosowicz, A.; Pyza, E.; Furness, D.N.; Kossut, M.; Glazewski, S.

    2010-01-01

    The structure of neurones changes during development and in response to injury or alteration in sensory experience. Changes occur in the number, shape and dimensions of dendritic spines together with their synapses. However, precise data on these changes in response to learning are sparse. Here, we show using quantitative transmission electron microscopy that a simple form of learning involving mystacial vibrissae results in about 70% increase in the density of inhibitory synapses on spines of neurones located in layer IV barrels that represent the stimulated vibrissae. The spines contain one asymmetrical (excitatory) and one symmetrical (inhibitory) synapse (double-synapse spines) and their density increases 3-fold due to learning with no apparent change in the density of asymmetrical synapses. This effect seems to be specific for learning as pseudoconditioning (where the conditioned and unconditioned stimuli are delivered at random) does not lead to the enhancement of symmetrical synapses, but instead results in an up-regulation of asymmetrical synapses on spines. Symmetrical synapses of cells located in barrels receiving the conditioned stimulus show also a greater concentration of γ-amino-butyric acid (GABA) in their presynaptic terminals. These results indicate that the immediate effect of classical conditioning in the ‘conditioned’ barrels is rapid, pronounced and inhibitory. PMID:20089926

  12. Report to users of ATLAS

    SciTech Connect

    Ahmad, I.; Glagola, B.

    1995-05-01

    This report contains discussing in the following areas: Status of the Atlas accelerator; highlights of recent research at Atlas; concept for an advanced exotic beam facility based on Atlas; program advisory committee; Atlas executive committee; and Atlas and ANL physics division on the world wide web.

  13. Level 1 Radiance Scaling and Conditioning Algorithm Theoretical Basis

    NASA Technical Reports Server (NTRS)

    Bruegge, C.; Diner, D.; Korechoff, R.; Lee, M.

    2000-01-01

    The Algorithm Theoretical Basis (ATB) document describes the algorithms used to produce the Multi-angle Imaging SpectroRadiometer (MISR) Level 1B1 Radiometric Product, and certain parameters of the Level 1A Reformatted Annotated Product.

  14. The ATLAS Diamond Beam Monitor: Luminosity detector at the LHC

    NASA Astrophysics Data System (ADS)

    Schaefer, D. M.

    2016-07-01

    After the first three years of the LHC running, the ATLAS experiment extracted its pixel detector system to refurbish and re-position the optical readout drivers and install a new barrel layer of pixels. The experiment has also taken advantage of this access to install a set of beam monitoring telescopes with pixel sensors, four each in the forward and backward regions. These telescopes are based on chemical vapor deposited (CVD) diamond sensors to survive in this high radiation environment without needing extensive cooling. This paper describes the lessons learned in construction and commissioning of the ATLAS Diamond Beam Monitor (DBM). We show results from the construction quality assurance tests and commissioning performance, including results from cosmic ray running in early 2015.

  15. Theoretical Exploration of Barrel-Shaped Drops on Cactus Spines.

    PubMed

    Luo, Cheng

    2015-11-01

    To survive an arid environment, desert cacti are capable of harvesting water from fog by transporting condensed water drops using their spines. Cactus spines have a conical shape. In this work, on the basis of the difference of liquid pressure, a new theoretical model has been developed for a barrel-shaped liquid drop on a conical wire. This model is further simplified to interpret the effects of contact angles, conical angle, surface microgrooves, and gravity on the drop movement along a cactus spine. PMID:26473466

  16. Reversible man-in-the-barrel syndrome in myasthenia gravis

    PubMed Central

    Shah, Poornima A; Wadia, Pettarusp Murzban

    2016-01-01

    Man-in-the-barrel syndrome (MBS) is an uncommon presentation due to bilateral, predominantly proximal muscle weakness that has not been described to be associated with myasthenia gravis. We describe a case of myasthenia gravis presenting as MBS. Additionally, he had significant wasting of the deltoids bilaterally with fibrillations on electromyography (EMG) at rest and brief duration (3-6 ms) bi/triphasic motor unit potentials (MUPs) on submaximal effort apart from a decremental response on repetitive nerve stimulation (RNS) at 2 Hz. While electrophysiology is an important tool in the diagnosis of myasthenia gravis, pathological EMG patterns do not exclude the diagnosis of myasthenia gravis. PMID:27011638

  17. Silicon photomultiplier characterization for the GlueX barrel calorimeter

    SciTech Connect

    F. Barbosa, J.E. McKisson, J. McKisson, Y. Qiang, E. Smith, C. Zorn

    2012-12-01

    GlueX is a new detector being constructed at Jefferson Laboratory to study gluonic excitations and confinement via the detection of exotic meson states. The hermetic detector includes a barrel calorimeter where the photodetectors must operate in a high magnetic field exceeding 0.5 T. After extensive tests with a variety of sensors, the chosen photodetector will be a custom silicon photomultiplier (SiPM) array manufactured by Hamamatsu Corporation. This paper will focus on the characterization of the first 80 production samples of these SiPMs, including dark rate, photodetection efficiency (PDE), crosstalk, response uniformity and radiation tolerance.

  18. Fast Shower Simulation in the ATLAS Calorimeter

    SciTech Connect

    Barberio, E.; Boudreau, J.; Butler, B.; Cheung, S.L.; Dell'Acqua, A.; Di Simone, A.; Ehrenfeld, W.; Gallas, M.V.; Glazov, A.; Marshall, Z.; Mueller, J.; Placakyte, R.; Rimoldi, A.; Savard, P.; Tsulaia, V.; Waugh, A.; Young, C.C.; /SLAC

    2011-11-08

    The time to simulate pp collisions in the ATLAS detector is largely dominated by the showering of electromagnetic particles in the heavy parts of the detector, especially the electromagnetic barrel and endcap calorimeters. Two procedures have been developed to accelerate the processing time of electromagnetic particles in these regions: (1) a fast shower parameterisation and (2) a frozen shower library. Both work by generating the response of the calorimeter to electrons and positrons with Geant 4, and then reintroduce the response into the simulation at runtime. In the fast shower parameterisation technique, a parameterization is tuned to single electrons and used later by simulation. In the frozen shower technique, actual showers from low-energy particles are used in the simulation. Full Geant 4 simulation is used to develop showers down to {approx} 1 GeV, at which point the shower is terminated by substituting a frozen shower. Judicious use of both techniques over the entire electromagnetic portion of the ATLAS calorimeter produces an important improvement of CPU time. We discuss the algorithms and their performance in this paper.

  19. Calibration of the high resolution spectrometer barrel calorimeter at PEP

    SciTech Connect

    Loos, J.S.

    1983-01-01

    The High-Resolution Spectrometer (HRS) is a general-purpose detector for the study of high-energy electron-positron collisions. The HRS has been in data-taking operation since early 1982. This report covers the calibration of the barrel shower counter system. The barrel system consists of 40 modules placed in a circular arch having a mean radius of 2.1 m. Each module covers an azimuthal wedge of 9 degrees and has an active length of 3.0 m. There are three independent sections: (1) an inner sandwich of Pb and scintillator (NE110) of thickness 3 r.1., (2) a plane of 14 proportional wire cells equipped with charge-division read-out, and (3) an outer sandwich of Pb and scintillator (NE114) of thickness 8. r. 1. The light from the sandwich section is collected at both ends and is passed through long acrylic pipes (5 cm diameter, 162 cm long) to photomultipliers (Amperex XP2230) mounted outside the magnet steel.

  20. Double Barrel In Situ Recanalization of Thrombosed Nonretrievable IVC filter.

    PubMed

    Banerjee, Shubhabrata; Patel, Hiten M; Sheorain, Virender K; Grover, Tarun; Parakh, Rajiv

    2016-05-01

    We report a case of endovascular recanalization of complete thrombotic occlusion of the inferior vena cava (IVC) and bilateral iliac veins using the architectural knowledge of the in situ permanent IVC filter in a 23-year-old male. The infrarenal permanent IVC filter was TRAPEASE permanent vena cava filter (Cordis) placed at an outstation hospital for pulmonary embolism. Being permanent variant of filter, percutaneous removal was not possible. The patient had severe venous claudication and an attempt to recanalize the blocked filter was considered, in view of the age no justifiable indication for a long-term filter. After pharmacomechanical catheter-directed thrombolysis, there was residual focal flow-limiting thrombus within the filter. The design of the Trapease Cordis filter was instrumental in our decision to attempt to recanalize the filter in situ using 2 parallel stents with the filter struts as anchoring pillars in a double-barrel alignment. In similar cases of persistent Trapease filter-related thrombotic occlusion of the IVC, this double barrel in situ recanalization shall be a viable alternative to the well-described technique of crushing the filter and recanalizing it with a single stent. PMID:26902934

  1. An analysis of increasing the size of the strategic petroleum reserve to one billion barrels

    SciTech Connect

    Not Available

    1990-01-01

    The Department of Energy's Office of Energy Emergency Policy and Evaluation requested that the Energy Information Administration complete an analysis of the proposed expansion in the Strategic Petroleum Reserve (SPR) from its currently planned size of 750 million barrels to 1000 million barrels. Because the SPR contains only 580 million barrels at this point in time, the benefits and costs of increasing the SPR from 600 to 750 million barrels were also estimated. This report documents the assumptions, methodology, and results of the analysis. 17 figs., 15 tabs.

  2. Parallel access alignment network with barrel switch implementation for d-ordered vector elements

    NASA Technical Reports Server (NTRS)

    Barnes, George H. (Inventor)

    1980-01-01

    An alignment network between N parallel data input ports and N parallel data outputs includes a first and a second barrel switch. The first barrel switch fed by the N parallel input ports shifts the N outputs thereof and in turn feeds the N-1 input data paths of the second barrel switch according to the relationship X=k.sup.y modulo N wherein x represents the output data path ordering of the first barrel switch, y represents the input data path ordering of the second barrel switch, and k equals a primitive root of the number N. The zero (0) ordered output data path of the first barrel switch is fed directly to the zero ordered output port. The N-1 output data paths of the second barrel switch are connected to the N output ports in the reverse ordering of the connections between the output data paths of the first barrel switch and the input data paths of the second barrel switch. The second switch is controlled by a value m, which in the preferred embodiment is produced at the output of a ROM addressed by the value d wherein d represents the incremental spacing or distance between data elements to be accessed from the N input ports, and m is generated therefrom according to the relationship d=k.sup.m modulo N.

  3. Sensitivity Analysis for Hierarchical Models Employing "t" Level-1 Assumptions.

    ERIC Educational Resources Information Center

    Seltzer, Michael; Novak, John; Choi, Kilchan; Lim, Nelson

    2002-01-01

    Examines the ways in which level-1 outliers can impact the estimation of fixed effects and random effects in hierarchical models (HMs). Also outlines and illustrates the use of Markov Chain Monte Carlo algorithms for conducting sensitivity analyses under "t" level-1 assumptions, including algorithms for settings in which the degrees of freedom at…

  4. MOPITT V7 Level 1 & Level 2 Release Announcement

    Atmospheric Science Data Center

    2016-08-02

    MOPITT V7 Level 1 & Level 2 Release Announcement Wednesday, August 10, 2016 ... Infrared Radiances) •   MOP01    - MOPITT Level 1 Radiances   Several significant retrieval algorithm and product ... Featured improvements in the V7 retrieval products include (1) the representation of changing atmospheric concentrations of N2O, (2) ...

  5. Algorithm and implementation of muon trigger and data transmission system for barrel-endcap overlap region of the CMS detector

    NASA Astrophysics Data System (ADS)

    Zabolotny, W. M.; Byszuk, A.

    2016-03-01

    The CMS experiment Level-1 trigger system is undergoing an upgrade. In the barrel-endcap transition region, it is necessary to merge data from 3 types of muon detectors—RPC, DT and CSC. The Overlap Muon Track Finder (OMTF) uses the novel approach to concentrate and process those data in a uniform manner to identify muons and their transversal momentum. The paper presents the algorithm and FPGA firmware implementation of the OMTF and its data transmission system in CMS. It is foreseen that the OMTF will be subject to significant changes resulting from optimization which will be done with the aid of physics simulations. Therefore, a special, high-level, parameterized HDL implementation is necessary.

  6. Agriculture, Levels 1-4. Agriculture & Commercial Horticulture, Levels 1-4. Commercial Horticulture, Levels 1-3. Environmental Conservation, Levels 2-4. National Vocational Qualifications.

    ERIC Educational Resources Information Center

    Business and Technology Education Council, London (England).

    Britain's National Vocational Qualifications (NVQs) are work qualifications that measure what an employee or potential employee can do as well as how much he or she knows and understands about a particular job. Used as written proof of usable workplace skills that can be put to profitable use by an employer, NVQs range from basic Level 1, for…

  7. BNL ATLAS Grid Computing

    ScienceCinema

    Michael Ernst

    2010-01-08

    As the sole Tier-1 computing facility for ATLAS in the United States and the largest ATLAS computing center worldwide Brookhaven provides a large portion of the overall computing resources for U.S. collaborators and serves as the central hub for storing,

  8. Language Industries Atlas.

    ERIC Educational Resources Information Center

    Hearn, P. M., Ed.; Button, D. F., Ed.

    This atlas describes the activities of public and private organizations that create the infrastructure within which languages are able to develop and interact in the European Community (EC). It contains over 1,000 descriptions of activities that play a role in shaping the language industries, from a user or provider perspective. The atlas is…

  9. ATLAS ACCEPTANCE TEST

    SciTech Connect

    J.C. COCHRANE; J.V. PARKER; ET AL

    2001-06-01

    The acceptance test program for Atlas, a 23 MJ pulsed power facility for use in the Los Alamos High Energy Density Hydrodynamics program, has been completed. Completion of this program officially releases Atlas from the construction phase and readies it for experiments. Details of the acceptance test program results and of machine capabilities for experiments will be presented.

  10. BNL ATLAS Grid Computing

    SciTech Connect

    Michael Ernst

    2008-10-02

    As the sole Tier-1 computing facility for ATLAS in the United States and the largest ATLAS computing center worldwide Brookhaven provides a large portion of the overall computing resources for U.S. collaborators and serves as the central hub for storing,

  11. Modeling of gun barrel surface erosion: Historic perspective

    SciTech Connect

    Buckingham, A.C.

    1996-08-01

    Results and interpretations of numerical simulations of some dominant processes influencing gun barrel propellant combustion and flow-induced erosion are presented. Results include modeled influences of erosion reduction techniques such as solid additives, vapor phase chemical modifications, and alteration of surface solid composition through use of thin coatings. Precedents and historical perspective are provided with predictions from traditional interior ballistics compared to computer simulations. Accelerating reactive combustion flow, multiphase and multicomponent transport, flow-to-surface thermal/momentum/phase change/gas-surface chemical exchanges, surface and micro-depth subsurface heating/stress/composition evolution and their roles in inducing surface cracking, spall, ablation, melting, and vaporization are considered. Recognition is given to cyclic effects of previous firing history on material preconditioning. Current perspective and outlook for future are based on results of a US Army-LLNL erosion research program covering 7 y in late 1970s. This is supplemented by more recent research on hypervelocity electromagnetic projectile launchers.

  12. Alcohol dehydrogenase polymorphism in barrel cactus populations of Drosophila mojavensis.

    PubMed

    Cleland, S; Hocutt, G D; Breitmeyer, C M; Markow, T A; Pfeiler, E

    1996-07-01

    Starch gel electrophoresis revealed that the alcohol dehydrogenase (ADH-2) locus was polymorphic in two populations (from Agua Caliente, California and the Grand Canyon, Arizona) of cactophilic Drosophila mojavensis that utilize barrel cactus (Ferocactus acanthodes) as a host plant. Electromorphs representing products of a slow (S) and a fast (F) allele were found in adult flies. The frequency of the slow allele was 0.448 in flies from Agua Caliente and 0.659 in flies from the Grand Canyon. These frequencies were intermediate to those of the low (Baja California peninsula, Mexico) and high (Sonora, Mexico and southern Arizona) frequency Adh-2S populations of D. mojavensis that utilize different species of host cacti. PMID:8765684

  13. Modelling the behaviour of additives in gun barrels

    NASA Astrophysics Data System (ADS)

    Rhodes, N.; Ludwig, J. C.

    1986-01-01

    A mathematical model which predicts the flow and heat transfer in a gun barrel is described. The model is transient, two-dimensional and equations are solved for velocities and enthalpies of a gas phase, which arises from the combustion of propellant and cartridge case, for particle additives which are released from the case; volume fractions of the gas and particles. Closure of the equations is obtained using a two-equation turbulence model. Preliminary calculations are described in which the proportions of particle additives in the cartridge case was altered. The model gives a good prediction of the ballistic performance and the gas to wall heat transfer. However, the expected magnitude of reduction in heat transfer when particles are present is not predicted. The predictions of gas flow invalidate some of the assumptions made regarding case and propellant behavior during combustion and further work is required to investigate these effects and other possible interactions, both chemical and physical, between gas and particles.

  14. Diabetes Interactive Atlas.

    PubMed

    Kirtland, Karen A; Burrows, Nilka R; Geiss, Linda S

    2014-01-01

    The Diabetes Interactive Atlas is a recently released Web-based collection of maps that allows users to view geographic patterns and examine trends in diabetes and its risk factors over time across the United States and within states. The atlas provides maps, tables, graphs, and motion charts that depict national, state, and county data. Large amounts of data can be viewed in various ways simultaneously. In this article, we describe the design and technical issues for developing the atlas and provide an overview of the atlas' maps and graphs. The Diabetes Interactive Atlas improves visualization of geographic patterns, highlights observation of trends, and demonstrates the concomitant geographic and temporal growth of diabetes and obesity. PMID:24503340

  15. National Atlas maps

    USGS Publications Warehouse

    U.S. Geological Survey

    1991-01-01

    The National Atlas of the United States of America was published by the U.S. Geological Survey in 1970. Its 765 maps and charts are on 335 14- by 19-inch pages. Many of the maps span facing pages. It's worth a quick trip to the library just to leaf through all 335 pages of this book. Rapid scanning of its thematic maps yields rich insights to the geography of issues of continuing national interest. On most maps, the geographic patterns are still valid, though the data are not current. The atlas is out of print, but many of its maps can be purchased separately. Maps that span facing pages in the atlas are printed on one sheet. The maps dated after 1970 are either revisions of original atlas maps, or new maps published in atlas format. The titles of the separate maps are listed here.

  16. 15 CFR 241.6 - Classes of barrels for tolerance application.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 shall include (1) all barrels no dimension of which is in error by more than the following amounts, and (2) all barrels one or more of the dimensions of which are in error by more than the following amounts, and which in addition have no dimension in error in the opposite direction: Error,...

  17. 15 CFR 241.6 - Classes of barrels for tolerance application.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 shall include (1) all barrels no dimension of which is in error by more than the following amounts, and (2) all barrels one or more of the dimensions of which are in error by more than the following amounts, and which in addition have no dimension in error in the opposite direction: Error,...

  18. Tapered laser rods as a means of minimizing the path length of trapped barrel mode rays

    DOEpatents

    Beach, Raymond J.; Honea, Eric C.; Payne, Stephen A.; Mercer, Ian; Perry, Michael D.

    2005-08-30

    By tapering the diameter of a flanged barrel laser rod over its length, the maximum trapped path length of a barrel mode can be dramatically reduced, thereby reducing the ability of the trapped spontaneous emission to negatively impact laser performance through amplified spontaneous emission (ASE). Laser rods with polished barrels and flanged end caps have found increasing application in diode array end-pumped laser systems. The polished barrel of the rod serves to confine diode array pump light within the rod. In systems utilizing an end-pumping geometry and such polished barrel laser rods, the pump light that is introduced into one or both ends of the laser rod, is ducted down the length of the rod via the total internal reflections (TIRs) that occur when the light strikes the rod's barrel. A disadvantage of using polished barrel laser rods is that such rods are very susceptible to barrel mode paths that can trap spontaneous emission over long path lengths. This trapped spontaneous emission can then be amplified through stimulated emission resulting in a situation where the stored energy available to the desired lasing mode is effectively depleted, which then negatively impacts the laser's performance, a result that is effectively reduced by introducing a taper onto the laser rod.

  19. Indiana Reading List. [Levels 1, 2, 3, and 4].

    ERIC Educational Resources Information Center

    Indiana State Dept. of Education, Indianapolis.

    This reading list is designed as a companion piece to Indiana's Academic Standards in English/Language Arts and is organized on four levels: Level 1, Grades K-2; Level 2, Grades 3-5; Level 3, Grades 6-8; and Level 4, Grades 9-12. It contains titles and authors for approximately 800 works. The Level 1 Reading List contains these sections: fiction…

  20. The Algorithm Theoretical Basis Document for Level 1A Processing

    NASA Technical Reports Server (NTRS)

    Jester, Peggy L.; Hancock, David W., III

    2012-01-01

    The first process of the Geoscience Laser Altimeter System (GLAS) Science Algorithm Software converts the Level 0 data into the Level 1A Data Products. The Level 1A Data Products are the time ordered instrument data converted from counts to engineering units. This document defines the equations that convert the raw instrument data into engineering units. Required scale factors, bias values, and coefficients are defined in this document. Additionally, required quality assurance and browse products are defined in this document.

  1. Effect of barrel design and the inoculation of Acetobacter pasteurianus in wine vinegar production.

    PubMed

    Hidalgo, C; Vegas, C; Mateo, E; Tesfaye, W; Cerezo, A B; Callejón, R M; Poblet, M; Guillamón, J M; Mas, A; Torija, M J

    2010-06-30

    The traditional production of wine vinegar is a lengthy process with little or no microbiological control. The aim of this study was to shorten the acetification process via three different strategies: changes in wood type; barrel shape; and the inoculation of an Acetobacter pasteurianus pure culture. The barrel shape was modified by constructing two prototypes with higher liquid-air interface. We compared the changes in acetic acid bacteria (AAB) population dynamics in these barrels with those of a submerged method. The wood type had no effect on the acetification length, whereas the shape of the barrel resulted in a significant shortening of the acetification length. Although the selected AAB strain did not always take over, it reduced the biodiversity of the AAB. The inoculated strain was predominant in oak barrels, whereas in the highly aerated prototypes Gluconacetobacter species (Ga. intermedius and/or Ga. europaeus) displaced A. pasteurianus, as what occurs in the submerged method. PMID:20478638

  2. [Research on Atlas of Viscera].

    PubMed

    Jin, S

    1994-01-01

    Chinese ancient visceral atlas, or anatomical illustrations were derived from Taoist and medical schools through observation in cadavers. During the period from Five-Dynasties to Song, there were several works on visceral atlas, including Yanluo illustration, Atlas of Ou Xifan's visceral atlas of fidelity, Li Jung's Atlas. Among them, there exist relations of transmission-heredity, with gradual improvement. It seems likely that the visceral illustrations in Japanese Wan'an Prescription is the extant illustration of Ou's. After the advent of Atlas of Fidelity visceral atlas was differentiated into 3 different kinds of illustrations, as the Inner Picture (Neijing) of Mingtang Atlas; Neizhao Picture in pulsological works and visceral picture in physical Shenxing picture. Chinese visceral atlas was transmitted to Japan, Korea, Persia, and Europe and exerted some influence on cosmopolitan medicine. PMID:11615236

  3. Commissioning of the ATLAS inner detector with cosmic rays

    NASA Astrophysics Data System (ADS)

    Hayward, H.

    2008-07-01

    The inner detector of the ATLAS experiment is in the process of being commissioned using cosmic ray events. First tests were performed in the SR1 assembly hall at CERN with both barrel and endcaps for all different detector technologies (pixels and microstrips silicon detectors as well as straw tubes with additional transition radiation detection). Integration with the rest of the ATLAS sub-detectors is now being done in the ATLAS cavern. The full software chain has been set up in order to reconstruct and analyse this kind of events. Final detector decoders have been developed, different pattern recognition algorithms and track fitters have been validated as well as the various alignment and calibration methods. The infrastructure to deal with conditions data coming from the data acquisition, detector control system and calibration runs has been put in place, allowing also to apply alignment and calibration constants. The software has also been essential to monitor the detector performance during data taking. Detector efficiencies, noise occupancies and resolutions have been studied in detail and compared with those obtained from simulation.

  4. ATLAS solar pointing operations

    NASA Technical Reports Server (NTRS)

    Tyler, C. A.; Zimmerman, C. J.

    1994-01-01

    The ATLAS-series of Spacelab missions are comprised of a diverse group of scientific instruments including instruments for studying the sun and how the sun's energy changes across an eleven-year solar cycle. The ATLAS solar instruments are located on one or more pallets in the Orbiter payload bay and use the Orbiter as a pointing platform for their examinations of the sun. One of the ATLAS instruments contained a sun sensor which allowed scientists and engineers on the ground to see the pointing error of the sun with respect to the instrument and correct for the error based upon the information coming from the ATLAS 1 and ATLAS 2 missions with particular attention given to identifying the sources of pointing discrepancies of the solar instruments and to describe the crew and ground controller procedures that were developed to correct for these discrepancies. The Orbiter pointing behavior from the ATLAS 1 and ATLAS 2 flights presented in this paper can be applied to future flights which use the Orbiter as a pointing platform.

  5. Upgrades of the ATLAS muon spectrometer with sMDT chambers

    NASA Astrophysics Data System (ADS)

    Ferretti, C.; Kroha, H.

    2016-07-01

    With half the drift-tube diameter of the Monitored Drift Tube (MDT) chambers of the ATLAS muon spectrometer and otherwise unchanged operating parameters, small-diameter Muon Drift Tube (sMDT) chambers provide an order of magnitude higher rate capability and can be installed in detector regions where MDT chambers do not fit. The chamber assembly time has been reduced by a factor of seven to one working day and the sense wire positioning accuracy improved by a factor of two to better than ten microns. Two sMDT chambers have been installed in ATLAS in 2014 to improve the momentum resolution in the barrel part of the spectrometer. The construction of an additional twelve chambers covering the feet regions of the ATLAS detector has started. It will be followed by the replacement of the MDT chambers at the ends of the barrel inner layer by sMDTs improving the performance at the high expected background rates and providing space for additional RPC trigger chambers.

  6. The Millennium Star Atlas

    NASA Astrophysics Data System (ADS)

    Sinnott, R. W.

    1997-08-01

    Derived from Hipparcos and Tycho observations, the Millennium Star Atlas is a set of 1548 charts covering the entire sky to about magnitude 11. It stands apart from all previous printed atlases in completeness to magnitude 10 and in uniformity around the sky. The generous chart scale has made possible a number of innovations never before seen in a star atlas: arrows on high-proper-motion stars, double-star ticks conveying separation and position angle for a specific modern epoch, distance labels for nearby stars, and variable stars coded by amplitude, period, and type. Among the nonstellar objects plotted, more than 8000 galaxies are shown with aspect ratio and orientation.

  7. Level 1 Processing of MODIS Direct Broadcast Data From Terra

    NASA Technical Reports Server (NTRS)

    Lynnes, Christopher; Smith, Peter; Shotland, Larry; El-Ghazawi, Tarek; Zhu, Ming

    2000-01-01

    In February 2000, an effort was begun to adapt the Moderate Resolution Imaging Spectroradiometer (MODIS) Level 1 production software to process direct broadcast data. Three Level 1 algorithms have been adapted and packaged for release: Level 1A converts raw (level 0) data into Hierarchical Data Format (HDF), unpacking packets into scans; Geolocation computes geographic information for the data points in the Level 1A; and the Level 1B computes geolocated, calibrated radiances from the Level 1A and Geolocation products. One useful aspect of adapting the production software is the ability to incorporate enhancements contributed by the MODIS Science Team. We have therefore tried to limit changes to the software. However, in order to process the data immediately on receipt, we have taken advantage of a branch in the geolocation software that reads orbit and altitude information from the packets themselves, rather than external ancillary files used in standard production. We have also verified that the algorithms can be run with smaller time increments (2.5 minutes) than the five-minute increments used in production. To make the code easier to build and run, we have simplified directories and build scripts. Also, dependencies on a commercial numerics library have been replaced by public domain software. A version of the adapted code has been released for Silicon Graphics machines running lrix. Perhaps owing to its origin in production, the software is rather CPU-intensive. Consequently, a port to Linux is underway, followed by a version to run on PC clusters, with an eventual goal of running in near-real-time (i.e., process a ten-minute pass in ten minutes).

  8. Structural insight into the biogenesis of β-barrel membrane proteins.

    PubMed

    Noinaj, Nicholas; Kuszak, Adam J; Gumbart, James C; Lukacik, Petra; Chang, Hoshing; Easley, Nicole C; Lithgow, Trevor; Buchanan, Susan K

    2013-09-19

    β-barrel membrane proteins are essential for nutrient import, signalling, motility and survival. In Gram-negative bacteria, the β-barrel assembly machinery (BAM) complex is responsible for the biogenesis of β-barrel membrane proteins, with homologous complexes found in mitochondria and chloroplasts. Here we describe the structure of BamA, the central and essential component of the BAM complex, from two species of bacteria: Neisseria gonorrhoeae and Haemophilus ducreyi. BamA consists of a large periplasmic domain attached to a 16-strand transmembrane β-barrel domain. Three structural features shed light on the mechanism by which BamA catalyses β-barrel assembly. First, the interior cavity is accessible in one BamA structure and conformationally closed in the other. Second, an exterior rim of the β-barrel has a distinctly narrowed hydrophobic surface, locally destabilizing the outer membrane. And third, the β-barrel can undergo lateral opening, suggesting a route from the interior cavity in BamA into the outer membrane. PMID:23995689

  9. Dynamically tuned shroud for gun barrel vibration attenuation

    NASA Astrophysics Data System (ADS)

    Littlefield, Andrew G.; Kathe, Eric L.; Durocher, Robert

    2002-06-01

    Modern tank guns, such as the one on the Abrams, are stabilized to allow fire on the move while traversing uneven terrain. The current barrel is short enough that treating as a rigid beam allows engagement of another tank at ranges of over a kilometer. However, as the length of the tube is extended, to meet required muzzle exit velocities, the terrain induced vibrations lead to increased muzzle pointing errors. A method to reduce these vibrations is to use the forward thermal shroud as part of a mass tuned damper. In this case the system under study is an extended length version of the gun currently fielded. This extended length increases its susceptibility to terrain-induced vibrations. The forward thermal shroud has been shortened and additional mass has been added onto its forward collar. This collar is then supported by springs, which are preloaded so that they stay in contact through the full range of the shroud's movement. Varying the stiffness of these springs allows for tuning of the absorber. Different types of springs and attachments have been tried. The current version uses leaf springs and a wedge collar. This system has been modeled and experiments conducted to validate the model.

  10. Performance of prototypes for the PANDA barrel EMC

    NASA Astrophysics Data System (ADS)

    Bremer, D. A.; Eissner, T.; Drexler, P.; Moritz, M.; Novotny, R. W.; PANDA Collaboration

    2015-02-01

    The PANDA experiment will be part of the future Facility for Antiproton and Ion Research (FAIR) and aims for the study of strong interaction within the charm sector via antiproton proton collisions up to antiproton momenta of 15 GeV/c. Reflecting the variety of the physics program the PANDA detector is designed as a multi-purpose detector able to perform tracking, calorimetry and particle identification with nearly complete coverage of the solid angle. The Electromagnetic Calorimeter (EMC) contained inside its Target Spectrometer is based on cooled PbWO4 scintillator crystals. In order to ensure an excellent performance throughout the large dynamic range of photon/electron energies ranging from a few MeV up to 15 GeV an extensive prototyping phase is mandatory. This contribution describes the measured response of the EMC barrel part prototype PROTO60 at the largest design energy to secondary beams provided by the SPS at CERN. In addition to PROTO60 a tracking station was deployed, providing precise position information of the 15 GeV/c positrons. For calibration purposes a 150 GeV/c muon beam and cosmic radiation, in combination with estimations from GEANT4 simulations were used. The obtained performance concerning energy, position and time information is presented.

  11. Development of the Oak Ridge Rutgers University Barrel Array

    NASA Astrophysics Data System (ADS)

    Pain, S. D.; Cizewski, J. A.; Hatarik, R.; Jones, K. L.; Sikora, M.; Thomas, J. S.; Bardayan, D. W.; Blackmon, J. C.; Nesaraja, C. J.; Smith, M. S.; Howard, J.; Kozub, R. L.; James, J.; Livesay, R. J.; Gaddis, A.; Johnson, M. S.; Moazen, B. H.

    2006-10-01

    The development of high quality RIBs, such as those at the HRIBF at ORNL, has made possible the performance of transfer reactions on unstable nuclei. Measurements of (d,p) reactions on n-rich fission fragments yield data on nuclear structure away from stability, are of importance to stewardship science and are of astrophysical interest due to the proximity to suggested r-process paths. Experimentally, (d,p) reactions on heavy (Z=50) fission fragments are complicated by the strongly inverse kinematics and low beam intensities. Ejectile detection with high resolution in position and energy, a high dynamic range and a high solid angular coverage is required. The Oak Ridge Rutgers University Barrel Array (ORRUBA) is currently under development for such measurements, providing a high solid angular coverage for angles forward and backward of 90 degrees. Resistive strip silicon detectors are used to obtain high- precision position and energy measurement, and δE-E particle identification is employed at angles forward of θlab = 90^o. The array's scientific motivation and technical aspects will be presented, along with a report of the first measurements performed with an early implementation of ORRUBA.

  12. Performance of the GlueX Barrel Calorimeter

    NASA Astrophysics Data System (ADS)

    Smith, Elton; Dalton, Mark; McGinley, William; Papandreou, Zisis; GlueX Collaboration

    2015-10-01

    The GlueX experiment at Jefferson Lab will search for exotic hybrid mesons, a new form of hadronic matter that exhibits gluonic degrees of freedom. We have taken data to commission the experiment and report here on the construction and performance of the electromagnetic barrel calorimeter (BCAL). The BCAL is a ``spaghetti calorimeter,'' consisting of layers of corrugated lead sheets, interleaved with planes of 1-mm-diameter, double-clad, scintillating fibers, bonded in the lead grooves using optical epoxy. This detector consists of 48 modules that are readout using 3,840 large-area Multi-Photon Pixel counter (MPPC) arrays. The measured width of the π0 mass peak is approximately 10 MeV, only slightly higher than projections based on prototypes. Systematic studies are underway to understand the contributions to the resolution and improve its performance. This material is based upon work supported by the U.S. Department of Energy, Office of Science, Office of Nuclear Physics under Contract DE-AC05-06OR23177.

  13. Double Barreled Wet Colostomy: Initial Experience and Literature Review

    PubMed Central

    Salgado-Cruz, Luis; Espin-Basany, Eloy; Vallribera-Valls, Francesc; Sanchez-Garcia, Jose; Jimenez-Gomez, Luis Miguel; Marti-Gallostra, Marc; Garza-Maldonado, Ana

    2014-01-01

    Background. Pelvic exenteration and multivisceral resection in colorectal have been described as a curative and palliative intervention. Urinary tract reconstruction in a pelvic exenteration is achieved in most cases with an ileal conduit of Bricker, although different urinary reservoirs have been described. Methods. A retrospective and observational study of six patients who underwent a pelvic exenteration and urinary tract reconstruction with a double barreled wet colostomy (DBWC) was done, describing the preoperative diagnosis, the indication for the pelvic exenteration, the complications associated with the procedure, and the followup in a period of 5 years. A literature review of the case series reported of the technique was performed. Results. Six patients had a urinary tract reconstruction with the DBWC technique, 5 male patients and one female patient. Age range was from 20 to 77 years, with a medium age 53.6 years. The most frequent complication presented was a pelvic abscess in 3 patients (42.85%); all complications could be resolved with a conservative treatment. Conclusion. In the group of our patients with pelvic exenteration and urinary tract reconstruction with a DBWC, it is a safe procedure and well tolerated by the patients, and most of the complications can be resolved with conservative treatment. PMID:25574498

  14. High Stimulus-Related Information in Barrel Cortex Inhibitory Interneurons

    PubMed Central

    Reyes-Puerta, Vicente; Kim, Suam; Sun, Jyh-Jang; Imbrosci, Barbara; Kilb, Werner; Luhmann, Heiko J.

    2015-01-01

    The manner in which populations of inhibitory (INH) and excitatory (EXC) neocortical neurons collectively encode stimulus-related information is a fundamental, yet still unresolved question. Here we address this question by simultaneously recording with large-scale multi-electrode arrays (of up to 128 channels) the activity of cell ensembles (of up to 74 neurons) distributed along all layers of 3–4 neighboring cortical columns in the anesthetized adult rat somatosensory barrel cortex in vivo. Using two different whisker stimulus modalities (location and frequency) we show that individual INH neurons – classified as such according to their distinct extracellular spike waveforms – discriminate better between restricted sets of stimuli (≤6 stimulus classes) than EXC neurons in granular and infra-granular layers. We also demonstrate that ensembles of INH cells jointly provide as much information about such stimuli as comparable ensembles containing the ~20% most informative EXC neurons, however presenting less information redundancy – a result which was consistent when applying both theoretical information measurements and linear discriminant analysis classifiers. These results suggest that a consortium of INH neurons dominates the information conveyed to the neocortical network, thereby efficiently processing incoming sensory activity. This conclusion extends our view on the role of the inhibitory system to orchestrate cortical activity. PMID:26098109

  15. High Stimulus-Related Information in Barrel Cortex Inhibitory Interneurons.

    PubMed

    Reyes-Puerta, Vicente; Kim, Suam; Sun, Jyh-Jang; Imbrosci, Barbara; Kilb, Werner; Luhmann, Heiko J

    2015-06-01

    The manner in which populations of inhibitory (INH) and excitatory (EXC) neocortical neurons collectively encode stimulus-related information is a fundamental, yet still unresolved question. Here we address this question by simultaneously recording with large-scale multi-electrode arrays (of up to 128 channels) the activity of cell ensembles (of up to 74 neurons) distributed along all layers of 3-4 neighboring cortical columns in the anesthetized adult rat somatosensory barrel cortex in vivo. Using two different whisker stimulus modalities (location and frequency) we show that individual INH neurons--classified as such according to their distinct extracellular spike waveforms--discriminate better between restricted sets of stimuli (≤6 stimulus classes) than EXC neurons in granular and infra-granular layers. We also demonstrate that ensembles of INH cells jointly provide as much information about such stimuli as comparable ensembles containing the ~20% most informative EXC neurons, however presenting less information redundancy - a result which was consistent when applying both theoretical information measurements and linear discriminant analysis classifiers. These results suggest that a consortium of INH neurons dominates the information conveyed to the neocortical network, thereby efficiently processing incoming sensory activity. This conclusion extends our view on the role of the inhibitory system to orchestrate cortical activity. PMID:26098109

  16. Crystal structures of a double-barrelled fluoride ion channel.

    PubMed

    Stockbridge, Randy B; Kolmakova-Partensky, Ludmila; Shane, Tania; Koide, Akiko; Koide, Shohei; Miller, Christopher; Newstead, Simon

    2015-09-24

    To contend with hazards posed by environmental fluoride, microorganisms export this anion through F(-)-specific ion channels of the Fluc family. Since the recent discovery of Fluc channels, numerous idiosyncratic features of these proteins have been unearthed, including strong selectivity for F(-) over Cl(-) and dual-topology dimeric assembly. To understand the chemical basis for F(-) permeation and how the antiparallel subunits convene to form a F(-)-selective pore, here we solve the crystal structures of two bacterial Fluc homologues in complex with three different monobody inhibitors, with and without F(-) present, to a maximum resolution of 2.1 Å. The structures reveal a surprising 'double-barrelled' channel architecture in which two F(-) ion pathways span the membrane, and the dual-topology arrangement includes a centrally coordinated cation, most likely Na(+). F(-) selectivity is proposed to arise from the very narrow pores and an unusual anion coordination that exploits the quadrupolar edges of conserved phenylalanine rings. PMID:26344196

  17. Cerebral glucose utilization after vasopressin barrel rotation or bicuculline seizures

    SciTech Connect

    Wurpel, J.; Dundore, R.; Bryan, R.; Keil, L.; Severs, W.B.

    1986-03-05

    Intraventricular (ivt) arginine vasopressin (AVP) causes a violent motor behavior termed barrel rotation (BR). AVP-BR is affected by visual/vestibular sensory input and may be related to other CNS motor disorders (seizures). Local cerebral glucose utilization (LCGU) was compared in SD rats during AVP-BR and bicuculline (BIC) seizures. Three groups were used: saline-ivt; AVP-ivt 0.5 ..mu..g; BIC-5.5 mg/kg,sc. /sup 14/C-glucose (40 ..mu..CI iv) was injected 15 sec. after ivt-saline or AVP or onset of BIC seizures. Rats were decapitated 10 min. after /sup 14/C-glucose. Brains were removed and dissected into 19 regions which were digested and glucose uptake quantified by liquid scintillation counting. LCGU was significantly increased in all CNS areas during BIC seizures vs controls (21-92%; p < 0.05 ANOVA). LCGU exhibits variable (upward arrow, downward arrow) changes in discrete areas during AVP-BR (p < .05). Glucose uptake increased in: cortex-olfactory (21%), sensory (9%), motor (8%) cerebellum-rt (13%) and 1t (17%) hemispheres, vermis (6%); pyramidal tract (6%); mesencephalon (5%); and pons (8%). Two areas decreased LCGU during AVP-BR: auditory cortex (-8%) and hippocampus (-11%). AVP-BR exhibits distinct changes in LCGU vs BIC seizures.

  18. Drift Time Measurement in the ATLAS Liquid Argon Electromagnetic Calorimeter using Cosmic Muons

    NASA Astrophysics Data System (ADS)

    Aad, G.; Abbott, B.; Abdallah, J.; Abdelalim, A. A.; Abdesselam, A.; Abdinov, O.; Abi, B.; Abolins, M.; Abramowicz, H.; Abreu, H.; Acharya, B. S.; Adams, D. L.; Addy, T. N.; Adelman, J.; Adorisio, C.; Adragna, P.; Adye, T.; Aefsky, S.; Aguilar-Saavedra, J. A.; Aharrouche, M.; Ahlen, S. P.; Ahles, F.; Ahmad, A.; Ahmed, H.; Ahsan, M.; Aielli, G.; Akdogan, T.; Åkesson, T. P. A.; Akimoto, G.; Akimov, A. V.; Aktas, A.; Alam, M. S.; Alam, M. A.; Albert, J.; Albrand, S.; Aleksa, M.; Aleksandrov, I. N.; Alessandria, F.; Alexa, C.; Alexander, G.; Alexandre, G.; Alexopoulos, T.; Alhroob, M.; Aliev, M.; Alimonti, G.; Alison, J.; Aliyev, M.; Allport, P. P.; Allwood-Spiers, S. E.; Almond, J.; Aloisio, A.; Alon, R.; Alonso, A.; Alviggi, M. G.; Amako, K.; Amelung, C.; Ammosov, V. V.; Amorim, A.; Amorós, G.; Amram, N.; Anastopoulos, C.; Andeen, T.; Anders, C. F.; Anderson, K. J.; Andreazza, A.; Andrei, V.; Anduaga, X. S.; Angerami, A.; Anghinolfi, F.; Anjos, N.; Antonaki, A.; Antonelli, M.; Antonelli, S.; Antos, J.; Antunovic, B.; Anulli, F.; Aoun, S.; Arabidze, G.; Aracena, I.; Arai, Y.; Arce, A. T. H.; Archambault, J. P.; Arfaoui, S.; Arguin, J.-F.; Argyropoulos, T.; Arik, E.; Arik, M.; Armbruster, A. J.; Arnaez, O.; Arnault, C.; Artamonov, A.; Arutinov, D.; Asai, M.; Asai, S.; Asfandiyarov, R.; Ask, S.; Åsman, B.; Asner, D.; Asquith, L.; Assamagan, K.; Astbury, A.; Astvatsatourov, A.; Atoian, G.; Auerbach, B.; Auge, E.; Augsten, K.; Aurousseau, M.; Austin, N.; Avolio, G.; Avramidou, R.; Axen, D.; Ay, C.; Azuelos, G.; Azuma, Y.; Baak, M. A.; Bacci, C.; Bach, A.; Bachacou, H.; Bachas, K.; Backes, M.; Badescu, E.; Bagnaia, P.; Bai, Y.; Bailey, D. C.; Bain, T.; Baines, J. T.; Baker, O. K.; Baker, M. D.; Baker, S.; Baltasar Dos Santos Pedrosa, F.; Banas, E.; Banerjee, P.; Banerjee, S.; Banfi, D.; Bangert, A.; Bansal, V.; Baranov, S. P.; Baranov, S.; Barashkou, A.; Barber, T.; Barberio, E. L.; Barberis, D.; Barbero, M.; Bardin, D. Y.; Barillari, T.; Barisonzi, M.; Barklow, T.; Barlow, N.; Barnett, B. M.; Barnett, R. M.; Baron, S.; Baroncelli, A.; Barr, A. J.; Barreiro, F.; Barreiro Guimarães da Costa, J.; Barrillon, P.; Barros, N.; Bartoldus, R.; Bartsch, D.; Bastos, J.; Bates, R. L.; Batkova, L.; Batley, J. R.; Battaglia, A.; Battistin, M.; Bauer, F.; Bawa, H. S.; Bazalova, M.; Beare, B.; Beau, T.; Beauchemin, P. H.; Beccherle, R.; Becerici, N.; Bechtle, P.; Beck, G. A.; Beck, H. P.; Beckingham, M.; Becks, K. H.; Bedajanek, I.; Beddall, A. J.; Beddall, A.; Bednár, P.; Bednyakov, V. A.; Bee, C.; Begel, M.; Behar Harpaz, S.; Behera, P. K.; Beimforde, M.; Belanger-Champagne, C.; Bell, P. J.; Bell, W. H.; Bella, G.; Bellagamba, L.; Bellina, F.; Bellomo, M.; Belloni, A.; Belotskiy, K.; Beltramello, O.; Ami, S. Ben; Benary, O.; Benchekroun, D.; Bendel, M.; Benedict, B. H.; Benekos, N.; Benhammou, Y.; Benincasa, G. P.; Benjamin, D. P.; Benoit, M.; Bensinger, J. R.; Benslama, K.; Bentvelsen, S.; Beretta, M.; Berge, D.; Bergeaas Kuutmann, E.; Berger, N.; Berghaus, F.; Berglund, E.; Beringer, J.; Bernardet, K.; Bernat, P.; Bernhard, R.; Bernius, C.; Berry, T.; Bertin, A.; Besana, M. I.; Besson, N.; Bethke, S.; Bianchi, R. M.; Bianco, M.; Biebel, O.; Biesiada, J.; Biglietti, M.; Bilokon, H.; Bindi, M.; Binet, S.; Bingul, A.; Bini, C.; Biscarat, C.; Bitenc, U.; Black, K. M.; Blair, R. E.; Blanchard, J.-B.; Blanchot, G.; Blocker, C.; Blocki, J.; Blondel, A.; Blum, W.; Blumenschein, U.; Bobbink, G. J.; Bocci, A.; Boehler, M.; Boek, J.; Boelaert, N.; Böser, S.; Bogaerts, J. A.; Bogouch, A.; Bohm, C.; Bohm, J.; Boisvert, V.; Bold, T.; Boldea, V.; Boldyrev, A.; Bondarenko, V. G.; Bondioli, M.; Boonekamp, M.; Bordoni, S.; Borer, C.; Borisov, A.; Borissov, G.; Borjanovic, I.; Borroni, S.; Bos, K.; Boscherini, D.; Bosman, M.; Bosteels, M.; Boterenbrood, H.; Bouchami, J.; Boudreau, J.; Bouhova-Thacker, E. V.; Boulahouache, C.; Bourdarios, C.; Boyd, J.; Boyko, I. R.; Bozovic-Jelisavcic, I.; Bracinik, J.; Braem, A.; Branchini, P.; Brandenburg, G. W.; Brandt, A.; Brandt, G.; Brandt, O.; Bratzler, U.; Brau, B.; Brau, J. E.; Braun, H. M.; Brelier, B.; Bremer, J.; Brenner, R.; Bressler, S.; Breton, D.; Britton, D.; Brochu, F. M.; Brock, I.; Brock, R.; Brodbeck, T. J.; Brodet, E.; Broggi, F.; Bromberg, C.; Brooijmans, G.; Brooks, W. K.; Brown, G.; Brubaker, E.; Bruckman de Renstrom, P. A.; Bruncko, D.; Bruneliere, R.; Brunet, S.; Bruni, A.; Bruni, G.; Bruschi, M.; Buanes, T.; Bucci, F.; Buchanan, J.; Buchholz, P.; Buckley, A. G.; Budagov, I. A.; Budick, B.; Büscher, V.; Bugge, L.; Bulekov, O.; Bunse, M.; Buran, T.; Burckhart, H.; Burdin, S.; Burgess, T.; Burke, S.; Busato, E.; Bussey, P.; Buszello, C. P.; Butin, F.; Butler, B.; Butler, J. M.; Buttar, C. M.; Butterworth, J. M.; Byatt, T.; Caballero, J.; Cabrera Urbán, S.; Caforio, D.; Cakir, O.; Calafiura, P.; Calderini, G.; Calfayan, P.; Calkins, R.; Caloba, L. P.; Caloi, R.; Calvet, D.; Camarri, P.; Cambiaghi, M.; Cameron, D.; Campabadal Segura, F.; Campana, S.; Campanelli, M.; Canale, V.; Canelli, F.; Canepa, A.; Cantero, J.; Capasso, L.; Capeans Garrido, M. D. M.; Caprini, I.; Caprini, M.; Capua, M.; Caputo, R.; Caracinha, D.; Caramarcu, C.; Cardarelli, R.; Carli, T.; Carlino, G.; Carminati, L.; Caron, B.; Caron, S.; Carrillo Montoya, G. D.; Carron Montero, S.; Carter, A. A.; Carter, J. R.; Carvalho, J.; Casadei, D.; Casado, M. P.; Cascella, M.; Caso, C.; Castaneda Hernadez, A. M.; Castaneda-Miranda, E.; Castillo Gimenez, V.; Castro, N.; Cataldi, G.; Catinaccio, A.; Catmore, J. R.; Cattai, A.; Cattani, G.; Caughron, S.; Cauz, D.; Cavalleri, P.; Cavalli, D.; Cavalli-Sforza, M.; Cavasinni, V.; Ceradini, F.; Cerqueira, A. S.; Cerri, A.; Cerrito, L.; Cerutti, F.; Cetin, S. 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S.; Levonian, S.; Lewandowska, M.; Leyton, M.; Li, H.; Li, J.; Li, S.; Li, X.; Liang, Z.; Liang, Z.; Liberti, B.; Lichard, P.; Lichtnecker, M.; Lie, K.; Liebig, W.; Liko, D.; Lilley, J. N.; Lim, H.; Limosani, A.; Limper, M.; Lin, S. C.; Lindsay, S. W.; Linhart, V.; Linnemann, J. T.; Liolios, A.; Lipeles, E.; Lipinsky, L.; Lipniacka, A.; Liss, T. M.; Lissauer, D.; Lister, A.; Litke, A. M.; Liu, C.; Liu, D.; Liu, H.; Liu, J. B.; Liu, M.; Liu, S.; Liu, T.; Liu, Y.; Livan, M.; Lleres, A.; Lloyd, S. L.; Lobodzinska, E.; Loch, P.; Lockman, W. S.; Lockwitz, S.; Loddenkoetter, T.; Loebinger, F. K.; Loginov, A.; Loh, C. W.; Lohse, T.; Lohwasser, K.; Lokajicek, M.; Loken, J.; Lopes, L.; Lopez Mateos, D.; Losada, M.; Loscutoff, P.; Losty, M. J.; Lou, X.; Lounis, A.; Loureiro, K. F.; Lovas, L.; Love, J.; Love, P.; Lowe, A. J.; Lu, F.; Lu, J.; Lubatti, H. 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M.; Manousakis-Katsikakis, A.; Mansoulie, B.; Mapelli, A.; Mapelli, L.; March, L.; Marchand, J. F.; Marchese, F.; Marchiori, G.; Marcisovsky, M.; Marino, C. P.; Marques, C. N.; Marroquim, F.; Marshall, R.; Marshall, Z.; Martens, F. K.; Marti I Garcia, S.; Martin, A. J.; Martin, A. J.; Martin, B.; Martin, B.; Martin, F. F.; Martin, J. P.; Martin, T. A.; Martin Dit Latour, B.; Martinez, M.; Martinez Outschoorn, V.; Martini, A.; Martyniuk, A. C.; Maruyama, T.; Marzano, F.; Marzin, A.; Masetti, L.; Mashimo, T.; Mashinistov, R.; Masik, J.; Maslennikov, A. L.; Massaro, G.; Massol, N.; Mastroberardino, A.; Masubuchi, T.; Mathes, M.; Matricon, P.; Matsunaga, H.; Matsushita, T.; Mattravers, C.; Maxfield, S. J.; May, E. N.; Mayne, A.; Mazini, R.; Mazur, M.; Mazzanti, M.; Mazzanti, P.; Mc Donald, J.; Mc Kee, S. P.; McCarn, A.; McCarthy, R. L.; McCubbin, N. A.; McFarlane, K. W.; McGlone, H.; McHedlidze, G.; McLaren, R. A.; McMahon, S. J.; McMahon, T. R.; McPherson, R. A.; Meade, A.; Mechnich, J.; Mechtel, M.; Medinnis, M.; Meera-Lebbai, R.; Meguro, T. M.; Mehdiyev, R.; Mehlhase, S.; Mehta, A.; Meier, K.; Meirose, B.; Melachrinos, C.; Melamed-Katz, A.; Mellado Garcia, B. R.; Meng, Z.; Menke, S.; Meoni, E.; Merkl, D.; Mermod, P.; Merola, L.; Meroni, C.; Merritt, F. S.; Messina, A. M.; Messmer, I.; Metcalfe, J.; Mete, A. S.; Meyer, J.-P.; Meyer, J.; Meyer, J.; Meyer, T. C.; Meyer, W. T.; Miao, J.; Michal, S.; Micu, L.; Middleton, R. P.; Migas, S.; Mijović, L.; Mikenberg, G.; Mikuž, M.; Miller, D. W.; Mills, W. J.; Mills, C. M.; Milov, A.; Milstead, D. A.; Minaenko, A. A.; Miñano, M.; Minashvili, I. A.; Mincer, A. I.; Mindur, B.; Mineev, M.; Ming, Y.; Mir, L. M.; Mirabelli, G.; Misawa, S.; Miscetti, S.; Misiejuk, A.; Mitrevski, J.; Mitsou, V. A.; Miyagawa, P. S.; Mjörnmark, J. U.; Mladenov, D.; Moa, T.; Moed, S.; Moeller, V.; Mönig, K.; Möser, N.; Mohn, B.; Mohr, W.; Mohrdieck-Möck, S.; Moles-Valls, R.; Molina-Perez, J.; Moloney, G.; Monk, J.; Monnier, E.; Montesano, S.; Monticelli, F.; Moore, R. W.; Mora Herrera, C.; Moraes, A.; Morais, A.; Morel, J.; Morello, G.; Moreno, D.; Llácer, M. Moreno; Morettini, P.; Morii, M.; Morley, A. K.; Mornacchi, G.; Morozov, S. V.; Morris, J. D.; Moser, H. G.; Mosidze, M.; Moss, J.; Mount, R.; Mountricha, E.; Mouraviev, S. V.; Moyse, E. J. W.; Mudrinic, M.; Mueller, F.; Mueller, J.; Mueller, K.; Müller, T. A.; Muenstermann, D.; Muir, A.; Munwes, Y.; Murillo Garcia, R.; Murray, W. J.; Mussche, I.; Musto, E.; Myagkov, A. G.; Myska, M.; Nadal, J.; Nagai, K.; Nagano, K.; Nagasaka, Y.; Nairz, A. M.; Nakamura, K.; Nakano, I.; Nakatsuka, H.; Nanava, G.; Napier, A.; Nash, M.; Nation, N. R.; Nattermann, T.; Naumann, T.; Navarro, G.; Nderitu, S. K.; Neal, H. A.; Nebot, E.; Nechaeva, P.; Negri, A.; Negri, G.; Nelson, A.; Nelson, T. K.; Nemecek, S.; Nemethy, P.; Nepomuceno, A. A.; Nessi, M.; Neubauer, M. S.; Neusiedl, A.; Neves, R. N.; Nevski, P.; Newcomer, F. M.; Nickerson, R. B.; Nicolaidou, R.; Nicolas, L.; Nicoletti, G.; Niedercorn, F.; Nielsen, J.; Nikiforov, A.; Nikolaev, K.; Nikolic-Audit, I.; Nikolopoulos, K.; Nilsen, H.; Nilsson, P.; Nisati, A.; Nishiyama, T.; Nisius, R.; Nodulman, L.; Nomachi, M.; Nomidis, I.; Nordberg, M.; Nordkvist, B.; Notz, D.; Novakova, J.; Nozaki, M.; Nožička, M.; Nugent, I. M.; Nuncio-Quiroz, A.-E.; Nunes Hanninger, G.; Nunnemann, T.; Nurse, E.; O'Neil, D. C.; O'Shea, V.; Oakham, F. G.; Oberlack, H.; Ochi, A.; Oda, S.; Odaka, S.; Odier, J.; Odino, G. A.; Ogren, H.; Oh, A.; Oh, S. H.; Ohm, C. C.; Ohshima, T.; Ohshita, H.; Ohsugi, T.; Okada, S.; Okawa, H.; Okumura, Y.; Olcese, M.; Olchevski, A. G.; Oliveira, M.; Oliveira Damazio, D.; Oliver, J.; Oliver Garcia, E.; Olivito, D.; Olszewski, A.; Olszowska, J.; Omachi, C.; Onofre, A.; Onyisi, P. U. E.; Oram, C. J.; Ordonez, G.; Oreglia, M. J.; Oren, Y.; Orestano, D.; Orlov, I.; Oropeza Barrera, C.; Orr, R. S.; Ortega, E. O.; Osculati, B.; Ospanov, R.; Osuna, C.; Otec, R.; P Ottersbach, J.; Ould-Saada, F.; Ouraou, A.; Ouyang, Q.; Owen, M.; Owen, S.; Oyarzun, A.; Ozcan, V. E.; Ozone, K.; Ozturk, N.; Pacheco Pages, A.; Padhi, S.; Padilla Aranda, C.; Paganis, E.; Pahl, C.; Paige, F.; Pajchel, K.; Palestini, S.; Pallin, D.; Palma, A.; Palmer, J. D.; Pan, Y. B.; Panagiotopoulou, E.; Panes, B.; Panikashvili, N.; Panitkin, S.; Pantea, D.; Panuskova, M.; Paolone, V.; Papadopoulou, Th. D.; Park, S. J.; Park, W.; Parker, M. A.; Parker, S. I.; Parodi, F.; Parsons, J. A.; Parzefall, U.; Pasqualucci, E.; Passardi, G.; Passeri, A.; Pastore, F.; Pastore, Fr.; Pásztor, G.; Pataraia, S.; Pater, J. R.; Patricelli, S.; Patwa, A.; Pauly, T.; Peak, L. S.; Pecsy, M.; Pedraza Morales, M. I.; Peleganchuk, S. V.; Peng, H.; Penson, A.; Penwell, J.; Perantoni, M.; Perez, K.; Perez Codina, E.; Pérez García-Estañ, M. T.; Perez Reale, V.; Perini, L.; Pernegger, H.; Perrino, R.; Perrodo, P.; Persembe, S.; Perus, P.; Peshekhonov, V. D.; Petersen, B. A.; Petersen, J.; Petersen, T. C.; Petit, E.; Petridou, C.; Petrolo, E.; Petrucci, F.; Petschull, D.; Petteni, M.; Pezoa, R.; Pfeifer, B.; Phan, A.; Phillips, A. W.; Piacquadio, G.; Piccinini, M.; Piegaia, R.; Pilcher, J. E.; Pilkington, A. D.; Pina, J.; Pinamonti, M.; Pinfold, J. L.; Ping, J.; Pinto, B.; Pizio, C.; Placakyte, R.; Plamondon, M.; Plano, W. G.; Pleier, M.-A.; Poblaguev, A.; Poddar, S.; Podlyski, F.; Poffenberger, P.; Poggioli, L.; Pohl, M.; Polci, F.; Polesello, G.; Policicchio, A.; Polini, A.; Poll, J.; Polychronakos, V.; Pomarede, D. M.; Pomeroy, D.; Pommès, K.; Pontecorvo, L.; Pope, B. G.; Popovic, D. S.; Poppleton, A.; Popule, J.; Portell Bueso, X.; Porter, R.; Pospelov, G. E.; Pospichal, P.; Pospisil, S.; Potekhin, M.; Potrap, I. N.; Potter, C. J.; Potter, C. T.; Potter, K. P.; Poulard, G.; Poveda, J.; Prabhu, R.; Pralavorio, P.; Prasad, S.; Pravahan, R.; Preda, T.; Pretzl, K.; Pribyl, L.; Price, D.; Price, L. E.; Prichard, P. M.; Prieur, D.; Primavera, M.; Prokofiev, K.; Prokoshin, F.; Protopopescu, S.; Proudfoot, J.; Prudent, X.; Przysiezniak, H.; Psoroulas, S.; Ptacek, E.; Puigdengoles, C.; Purdham, J.; Purohit, M.; Puzo, P.; Pylypchenko, Y.; Qi, M.; Qian, J.; Qian, W.; Qian, Z.; Qin, Z.; Qing, D.; Quadt, A.; Quarrie, D. R.; Quayle, W. B.; Quinonez, F.; Raas, M.; Radeka, V.; Radescu, V.; Radics, B.; Rador, T.; Ragusa, F.; Rahal, G.; Rahimi, A. M.; Rahm, D.; Rajagopalan, S.; Rammes, M.; Ratoff, P. N.; Rauscher, F.; Rauter, E.; Raymond, M.; Read, A. L.; Rebuzzi, D. M.; Redelbach, A.; Redlinger, G.; Reece, R.; Reeves, K.; Reinherz-Aronis, E.; Reinsch, A.; Reisinger, I.; Reljic, D.; Rembser, C.; Ren, Z. L.; Renkel, P.; Rescia, S.; Rescigno, M.; Resconi, S.; Resende, B.; Reznicek, P.; Rezvani, R.; Richards, A.; Richards, R. A.; Richter, R.; Richter-Was, E.; Ridel, M.; Rieke, S.; Rijpstra, M.; Rijssenbeek, M.; Rimoldi, A.; Rinaldi, L.; Rios, R. R.; Riu, I.; Rivoltella, G.; Rizatdinova, F.; Rizvi, E. R.; Roa Romero, D. A.; Robertson, S. H.; Robichaud-Veronneau, A.; Robinson, D.; Robinson, J.; Robinson, M.; Robson, A.; Rocha de Lima, J. G.; Roda, C.; Roda Dos Santos, D.; Rodriguez, D.; Rodriguez Garcia, Y.; Roe, S.; Røhne, O.; Rojo, V.; Rolli, S.; Romaniouk, A.; Romanov, V. M.; Romeo, G.; Romero Maltrana, D.; Roos, L.; Ros, E.; Rosati, S.; Rosenbaum, G. A.; Rosenberg, E. I.; Rosselet, L.; Rossetti, V.; Rossi, L. P.; Rotaru, M.; Rothberg, J.; Rottländer, I.; Rousseau, D.; Royon, C. R.; Rozanov, A.; Rozen, Y.; Ruan, X.; Ruckert, B.; Ruckstuhl, N.; Rud, V. I.; Rudolph, G.; Rühr, F.; Ruggieri, F.; Ruiz-Martinez, A.; Rumyantsev, L.; Rusakovich, N. A.; Rutherfoord, J. P.; Ruwiedel, C.; Ruzicka, P.; Ryabov, Y. F.; Ryadovikov, V.; Ryan, P.; Rybkin, G.; Rzaeva, S.; Saavedra, A. F.; Sadrozinski, H. F.-W.; Sadykov, R.; Sakamoto, H.; Salamanna, G.; Salamon, A.; Saleem, M.; Salihagic, D.; Salnikov, A.; Salt, J.; Salvachua Ferrando, B. M.; Salvatore, D.; Salvatore, F.; Salvucci, A.; Salzburger, A.; Sampsonidis, D.; Samset, B. H.; Sanchis Lozano, M. A.; Sandaker, H.; Sander, H. G.; Sanders, M. P.; Sandhoff, M.; Sandstroem, R.; Sandvoss, S.; Sankey, D. P. C.; Sanny, B.; Sansoni, A.; Santamarina Rios, C.; Santi, L.; Santoni, C.; Santonico, R.; Santos, J.; Saraiva, J. G.; Sarangi, T.; Sarkisyan-Grinbaum, E.; Sarri, F.; Sasaki, O.; Sasaki, T.; Sasao, N.; Satsounkevitch, I.; Sauvage, G.; Savard, P.; Savine, A. Y.; Savinov, V.; Sawyer, L.; Saxon, D. H.; Says, L. P.; Sbarra, C.; Sbrizzi, A.; Scannicchio, D. A.; Schaarschmidt, J.; Schacht, P.; Schäfer, U.; Schaetzel, S.; Schaffer, A. C.; Schaile, D.; Schamberger, R. D.; Schamov, A. G.; Schegelsky, V. A.; Scheirich, D.; Schernau, M.; Scherzer, M. I.; Schiavi, C.; Schieck, J.; Schioppa, M.; Schlenker, S.; Schlereth, J. L.; Schmid, P.; Schmieden, K.; Schmitt, C.; Schmitz, M.; Schott, M.; Schouten, D.; Schovancova, J.; Schram, M.; Schreiner, A.; Schroeder, C.; Schroer, N.; Schroers, M.; Schuler, G.; Schultes, J.; Schultz-Coulon, H.-C.; Schumacher, J. W.; Schumacher, M.; Schumm, B. A.; Schune, Ph.; Schwanenberger, C.; Schwartzman, A.; Schwemling, Ph.; Schwienhorst, R.; Schwierz, R.; Schwindling, J.; Scott, W. G.; Searcy, J.; Sedykh, E.; Segura, E.; Seidel, S. C.; Seiden, A.; Seifert, F.; Seixas, J. M.; Sekhniaidze, G.; Seliverstov, D. M.; Sellden, B.; Seman, M.; Semprini-Cesari, N.; Serfon, C.; Serin, L.; Seuster, R.; Severini, H.; Sevior, M. E.; Sfyrla, A.; Shabalina, E.; Shamim, M.; Shan, L. Y.; Shank, J. T.; Shao, Q. T.; Shapiro, M.; Shatalov, P. B.; Shaver, L.; Shaw, K.; Sherman, D.; Sherwood, P.; Shibata, A.; Shimojima, M.; Shin, T.; Shmeleva, A.; Shochet, M. J.; Shupe, M. A.; Sicho, P.; Sidoti, A.; Siebel, A.; Siegert, F.; Siegrist, J.; Sijacki, Dj.; Silbert, O.; Silva, J.; Silver, Y.; Silverstein, D.; Silverstein, S. B.; Simak, V.; Simic, Lj.; Simion, S.; Simmons, B.; Simonyan, M.; Sinervo, P.; Sinev, N. B.; Sipica, V.; Siragusa, G.; Sisakyan, A. N.; Sivoklokov, S. Yu.; Sjoelin, J.; Sjursen, T. B.; Skubic, P.; Skvorodnev, N.; Slater, M.; Slavicek, T.; Sliwa, K.; Sloper, J.; Sluka, T.; Smakhtin, V.; Smirnov, S. Yu.; Smirnov, Y.; Smirnova, L. N.; Smirnova, O.; Smith, B. C.; Smith, D.; Smith, K. M.; Smizanska, M.; Smolek, K.; Snesarev, A. A.; Snow, S. W.; Snow, J.; Snuverink, J.; Snyder, S.; Soares, M.; Sobie, R.; Sodomka, J.; Soffer, A.; Solans, C. A.; Solar, M.; Solc, J.; Solfaroli Camillocci, E.; Solodkov, A. A.; Solovyanov, O. V.; Soluk, R.; Sondericker, J.; Sopko, V.; Sopko, B.; Sosebee, M.; Sosnovtsev, V. 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C.; Vetterli, M. C.; Vichou, I.; Vickey, T.; Viehhauser, G. H. A.; Villa, M.; Villani, E. G.; Villaplana Perez, M.; Villate, J.; Vilucchi, E.; Vincter, M. G.; Vinek, E.; Vinogradov, V. B.; Viret, S.; Virzi, J.; Vitale, A.; Vitells, O. V.; Vivarelli, I.; Vives Vaques, F.; Vlachos, S.; Vlasak, M.; Vlasov, N.; Vogel, A.; Vokac, P.; Volpi, M.; Volpini, G.; von der Schmitt, H.; von Loeben, J.; von Radziewski, H.; von Toerne, E.; Vorobel, V.; Vorobiev, A. P.; Vorwerk, V.; Vos, M.; Voss, R.; Voss, T. T.; Vossebeld, J. H.; Vranjes, N.; Vranjes Milosavljevic, M.; Vrba, V.; Vreeswijk, M.; Vu Anh, T.; Vudragovic, D.; Vuillermet, R.; Vukotic, I.; Wagner, P.; Wahlen, H.; Walbersloh, J.; Walder, J.; Walker, R.; Walkowiak, W.; Wall, R.; Wang, C.; Wang, H.; Wang, J.; Wang, J. C.; Wang, S. M.; Ward, C. P.; Warsinsky, M.; Wastie, R.; Watkins, P. M.; Watson, A. T.; Watson, M. F.; Watts, G.; Watts, S.; Waugh, A. T.; Waugh, B. M.; Webel, M.; Weber, J.; Weber, M. D.; Weber, M.; Weber, M. S.; Weber, P.; Weidberg, A. R.; Weingarten, J.; Weiser, C.; Wellenstein, H.; Wells, P. S.; Wen, M.; Wenaus, T.; Wendler, S.; Wengler, T.; Wenig, S.; Wermes, N.; Werner, M.; Werner, P.; Werth, M.; Werthenbach, U.; Wessels, M.; Whalen, K.; Wheeler-Ellis, S. J.; Whitaker, S. P.; White, A.; White, M. J.; White, S.; Whiteson, D.; Whittington, D.; Wicek, F.; Wicke, D.; Wickens, F. J.; Wiedenmann, W.; Wielers, M.; Wienemann, P.; Wiglesworth, C.; Wiik, L. A. M.; Wildauer, A.; Wildt, M. A.; Wilhelm, I.; Wilkens, H. G.; Williams, E.; Williams, H. H.; Willis, W.; Willocq, S.; Wilson, J. A.; Wilson, M. G.; Wilson, A.; Wingerter-Seez, I.; Winklmeier, F.; Wittgen, M.; Wolter, M. W.; Wolters, H.; Wosiek, B. K.; Wotschack, J.; Woudstra, M. J.; Wraight, K.; Wright, C.; Wright, D.; Wrona, B.; Wu, S. L.; Wu, X.; Wulf, E.; Xella, S.; Xie, S.; Xie, Y.; Xu, D.; Xu, N.; Yamada, M.; Yamamoto, A.; Yamamoto, S.; Yamamura, T.; Yamanaka, K.; Yamaoka, J.; Yamazaki, T.; Yamazaki, Y.; Yan, Z.; Yang, H.; Yang, U. K.; Yang, Y.; Yang, Z.; Yao, W.-M.; Yao, Y.; Yasu, Y.; Ye, J.; Ye, S.; Yilmaz, M.; Yoosoofmiya, R.; Yorita, K.; Yoshida, R.; Young, C.; Youssef, S. P.; Yu, D.; Yu, J.; Yu, M.; Yu, X.; Yuan, J.; Yuan, L.; Yurkewicz, A.; Zaidan, R.; Zaitsev, A. M.; Zajacova, Z.; Zambrano, V.; Zanello, L.; Zarzhitsky, P.; Zaytsev, A.; Zeitnitz, C.; Zeller, M.; Zema, P. F.; Zemla, A.; Zendler, C.; Zenin, O.; Zenis, T.; Zenonos, Z.; Zenz, S.; Zerwas, D.; Zevi Della Porta, G.; Zhan, Z.; Zhang, H.; Zhang, J.; Zhang, Q.; Zhang, X.; Zhao, L.; Zhao, T.; Zhao, Z.; Zhemchugov, A.; Zheng, S.; Zhong, J.; Zhou, B.; Zhou, N.; Zhou, Y.; Zhu, C. G.; Zhu, H.; Zhu, Y.; Zhuang, X.; Zhuravlov, V.; Zimmermann, R.; Zimmermann, S.; Zimmermann, S.; Ziolkowski, M.; Zitoun, R.; Živković, L.; Zmouchko, V. V.; Zobernig, G.; Zoccoli, A.; Zur Nedden, M.; Zutshi, V.

    2010-12-01

    The ionization signals in the liquid argon of the ATLAS electromagnetic calorimeter are studied in detail using cosmic muons. In particular, the drift time of the ionization electrons is measured and used to assess the intrinsic uniformity of the calorimeter gaps and estimate its impact on the constant term of the energy resolution. The drift times of electrons in the cells of the second layer of the calorimeter are uniform at the level of 1.3% in the barrel and 2.8% in the endcaps. This leads to an estimated contribution to the constant term of (0.29^{+0.05}_{-0.04})% in the barrel and (0.54^{+0.06}_{-0.04})% in the endcaps. The same data are used to measure the drift velocity of ionization electrons in liquid argon, which is found to be 4.61±0.07 mm/μs at 88.5 K and 1 kV/mm.

  19. Atlas of nuclear medicine

    SciTech Connect

    Van Nostrand, D. ); Baum, S. )

    1988-01-01

    This book contains the proceeding on the atlas of nuclear medicine. Topics covered include: Radionuclide esophageal transit studies, Iodine-131 neck and chest scintigraphy, Indium-111 white blood cell imaging, and Pediatric radionuclide lymphography.

  20. ATLAS Metadata Task Force

    SciTech Connect

    ATLAS Collaboration; Costanzo, D.; Cranshaw, J.; Gadomski, S.; Jezequel, S.; Klimentov, A.; Lehmann Miotto, G.; Malon, D.; Mornacchi, G.; Nemethy, P.; Pauly, T.; von der Schmitt, H.; Barberis, D.; Gianotti, F.; Hinchliffe, I.; Mapelli, L.; Quarrie, D.; Stapnes, S.

    2007-04-04

    This document provides an overview of the metadata, which are needed to characterizeATLAS event data at different levels (a complete run, data streams within a run, luminosity blocks within a run, individual events).

  1. General Dynamics Atlas family

    NASA Astrophysics Data System (ADS)

    Oates, James

    Developments concerning the Atlas family of launch vehicles over the last three or four years are summarized. Attention is given to the center of gravity, load factors, acoustics, pyroshock, low-frequency sinusoidal vibration, and high-frequency random vibration.

  2. ATLAS accelerator laboratory report

    SciTech Connect

    Den Hartog, P.

    1986-01-01

    The operation of the ATLAS Accelerator is reported. Modifications are reported, including the installation of conductive tires for the Pelletron chain pulleys, installation of a new high frequency sweeper system at the entrance to the linac, and improvements to the rf drive ports of eight resonators to correct failures in the thermally conductive ceramic insulators. Progress is reported on the positive-ion injector upgrade for ATLAS. Also reported are building modifications and possible new uses for the tandem injector. (LEW)

  3. Atlas Skills for Learning Rather than Learning Atlas Skills.

    ERIC Educational Resources Information Center

    Carswell, R. J. B.

    1986-01-01

    Presents a model for visual learning and describes an approach to skills instruction which aids students in using atlases. Maintains that teachers must help students see atlases as tools capable of providing useful information rather than experiencing atlas learning as an empty exercise with little relevance to their lives. (JDH)

  4. Interactive Learning in a Higher Education Level 1 Mechanics Module.

    ERIC Educational Resources Information Center

    Booth, Kathryn M.; James, Brian W.

    2001-01-01

    Encourages Level 1 students (those taking a subject for the first time at the higher education level) to develop a deeper learning approach. Uses a cooperative learning approach to pose conceptual questions for interactive discussions and changes both teaching method and form of examination paper for a Mechanics module. (Contains 17 references.)…

  5. AIRS Level 1b Algorithm Theoretical Basis Document

    NASA Technical Reports Server (NTRS)

    Aumann, H.; Gregorich, D.; Gaiser, S.; Hagan, D.; Pagano, T.; Ting, D.

    2000-01-01

    The level 1b Algorithm Theoretical Basis Document (ATBD) describes the theoretical bases of the algorithms used to convert the raw detector output (data numbers) from the Atmospheric Infrared Sounder (AIRS), the Advanced Microwave Sounding Unit (AMSU) and Humidity Sounder Brazil (HSB) to physical radiance units and, in the case of AIRS, perform in-orbit spectral calibrations.

  6. Solution-Focused Group Therapy for Level 1 Substance Abusers

    ERIC Educational Resources Information Center

    Smock, Sara A.; Trepper, Terry S.; Wetchler, Joseph L.; McCollum, Eric E.; Ray, Rose; Pierce, Kent

    2008-01-01

    The present study compared solution-focused group therapy (SFGT) with a traditional problem-focused treatment for level 1 substance abusers. Outcome research on the effectiveness of solution-focused group therapy is minimal, especially in treating substance abusers. In the present study, clients were measured before and after treatment to…

  7. ATLAS@AWS

    NASA Astrophysics Data System (ADS)

    Gehrcke, Jan-Philip; Kluth, Stefan; Stonjek, Stefan

    2010-04-01

    We show how the ATLAS offline software is ported on the Amazon Elastic Compute Cloud (EC2). We prepare an Amazon Machine Image (AMI) on the basis of the standard ATLAS platform Scientific Linux 4 (SL4). Then an instance of the SLC4 AMI is started on EC2 and we install and validate a recent release of the ATLAS offline software distribution kit. The installed software is archived as an image on the Amazon Simple Storage Service (S3) and can be quickly retrieved and connected to new SL4 AMI instances using the Amazon Elastic Block Store (EBS). ATLAS jobs can then configure against the release kit using the ATLAS configuration management tool (cmt) in the standard way. The output of jobs is exported to S3 before the SL4 AMI is terminated. Job status information is transferred to the Amazon SimpleDB service. The whole process of launching instances of our AMI, starting, monitoring and stopping jobs and retrieving job output from S3 is controlled from a client machine using python scripts implementing the Amazon EC2/S3 API via the boto library working together with small scripts embedded in the SL4 AMI. We report our experience with setting up and operating the system using standard ATLAS job transforms.

  8. Atlas Mountain Range, Mali, Africa

    NASA Technical Reports Server (NTRS)

    1992-01-01

    ATLAS pallets are backdropped against the Atlas Mountains (31.0N, 1.0W). ATLAS is an acronym for ATmospheric Laboratory for Applications and Science. Taken from a point over Mali, in the western Sahara, the northwest looking view shows dunes in the Iguidi dune sea and colors characteristic of the Saharan side of the Atlas Mountains. The edge of a large sandstorm, that transported sand and dust to Yugoslavia and beyond, can also be seen.

  9. Report to users of ATLAS

    SciTech Connect

    Ahmad, I.; Glagola, B.

    1997-03-01

    This report covers the following topics: (1) status of the ATLAS accelerator; (2) progress in R and D towards a proposal for a National ISOL Facility; (3) highlights of recent research at ATLAS; (4) the move of gammasphere from LBNL to ANL; (5) Accelerator Target Development laboratory; (6) Program Advisory Committee; (7) ATLAS User Group Executive Committee; and (8) ATLAS user handbook available in the World Wide Web. A brief summary is given for each topic.

  10. [The composition and characteristics of the spread of the shot products from a gas-barrel weapon].

    PubMed

    Isakov, V D; Babakhanian, R V; Kuznetsov, Iu D; Sigalov, F A

    1998-01-01

    Chemical composition and diffusion of additional factors of a shot from barrel gun supplied with a standard chemical cartridge are studied. Experimental shots from gas pistols of three designs were made. During shots from gas barrel guns the victim is exposed to additional factors characteristic of both fire arms and gas barrel guns, namely, fragments of plastic cartridge container and pads, magnesium particles, and lacquer powder. The characteristics of the short range zone for gas barrel guns correspond to those of short barrel fire arms. PMID:9567673

  11. Long-range intralaminar noise correlations in the barrel cortex.

    PubMed

    Reyes-Puerta, Vicente; Amitai, Yael; Sun, Jyh-Jang; Shani, Itamar; Luhmann, Heiko J; Shamir, Maoz

    2015-05-01

    Identifying the properties of correlations in the firing of neocortical neurons is central to our understanding of cortical information processing. It has been generally assumed, by virtue of the columnar organization of the neocortex, that the firing of neurons residing in a certain vertical domain is highly correlated. On the other hand, firing correlations between neurons steeply decline with horizontal distance. Technical difficulties in sampling neurons with sufficient spatial information have precluded the critical evaluation of these notions. We used 128-channel "silicon probes" to examine the spike-count noise correlations during spontaneous activity between multiple neurons with identified laminar position and over large horizontal distances in the anesthetized rat barrel cortex. Eigen decomposition of correlation coefficient matrices revealed that the laminar position of a neuron is a significant determinant of these correlations, such that the fluctuations of layer 5B/6 neurons are in opposite direction to those of layers 5A and 4. Moreover, we found that within each experiment, the distribution of horizontal, intralaminar spike-count correlation coefficients, up to a distance of ∼1.5 mm, is practically identical to the distribution of vertical correlations. Taken together, these data reveal that the neuron's laminar position crucially affects its role in cortical processing. Moreover, our analyses reveal that this laminar effect extends over several functional columns. We propose that within the cortex the influence of the horizontal elements exists in a dynamic balance with the influence of the vertical domain and this balance is modulated with brain states to shape the network's behavior. PMID:25787960

  12. Long-range intralaminar noise correlations in the barrel cortex

    PubMed Central

    Reyes-Puerta, Vicente; Sun, Jyh-Jang; Shani, Itamar; Luhmann, Heiko J.; Shamir, Maoz

    2015-01-01

    Identifying the properties of correlations in the firing of neocortical neurons is central to our understanding of cortical information processing. It has been generally assumed, by virtue of the columnar organization of the neocortex, that the firing of neurons residing in a certain vertical domain is highly correlated. On the other hand, firing correlations between neurons steeply decline with horizontal distance. Technical difficulties in sampling neurons with sufficient spatial information have precluded the critical evaluation of these notions. We used 128-channel “silicon probes” to examine the spike-count noise correlations during spontaneous activity between multiple neurons with identified laminar position and over large horizontal distances in the anesthetized rat barrel cortex. Eigen decomposition of correlation coefficient matrices revealed that the laminar position of a neuron is a significant determinant of these correlations, such that the fluctuations of layer 5B/6 neurons are in opposite direction to those of layers 5A and 4. Moreover, we found that within each experiment, the distribution of horizontal, intralaminar spike-count correlation coefficients, up to a distance of ∼1.5 mm, is practically identical to the distribution of vertical correlations. Taken together, these data reveal that the neuron's laminar position crucially affects its role in cortical processing. Moreover, our analyses reveal that this laminar effect extends over several functional columns. We propose that within the cortex the influence of the horizontal elements exists in a dynamic balance with the influence of the vertical domain and this balance is modulated with brain states to shape the network's behavior. PMID:25787960

  13. Correction: Reversibility and two state behaviour in the thermal unfolding of oligomeric TIM barrel proteins.

    PubMed

    Romero-Romero, Sergio; Costas, Miguel; Rodríguez-Romero, Adela; Fernández-Velasco, D Alejandro

    2016-04-21

    Correction for 'Reversibility and two state behaviour in the thermal unfolding of oligomeric TIM barrel proteins' by Sergio Romero-Romero et al., Phys. Chem. Chem. Phys., 2015, 17, 20699-20714. PMID:27010946

  14. 77 FR 45490 - Safety Zone, Barrel Recovery, Lake Superior; Duluth, MN

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-01

    ... FR Federal Register NPRM Notice of Proposed Rulemaking A. Regulatory History and Information The..., Navigation (water), Reporting and recordkeeping requirements, Security measures, Waterways. For the reasons... conduct recovery and testing of barrels suspected to contain munitions waste materials which were...

  15. EXTERNAL BARREL TEMPERATURE OF A SMALL BORE OLYMPIC RIFLE AND SHOOTING PRECISION

    PubMed Central

    Gladyszewska, B.; Baranowski, P.; Mazurek, W.; Wozniak, J.

    2013-01-01

    Investigations on changes in a rifle's barrel temperature during shooting in a rhythm typical for practitioners of Olympic shooting sports are presented. Walther KK300 (cal. 5.6 mm), a typical rifle often used in Olympic competitions, R50 RWS ammunition and a high speed thermographic camera were used in the study. Altair version 5 software was used to process thermal images and a stationary wavelet transform was applied to denoise signals for all the studied points. It was found that the temperature of the rifle barrel does not exceed 0.3°C after one shot whereas the total temperature increase does not exceed 5°C after taking 40 shots and does not affect the position of the hitting point on a target. In fact, contrary to popular belief, the so-called “warming shots” are not done for barrel heating but for cleaning of remnants in the barrel. PMID:24744465

  16. The structural biology of β-barrel membrane proteins: a summary of recent reports

    PubMed Central

    Fairman, James W.; Noinaj, Nicholas; Buchanan, Susan K.

    2011-01-01

    The outer membranes of Gram-negative bacteria, mitochondria, and chloroplasts all contain transmembrane β-barrel proteins. These β-barrel proteins serve essential functions in cargo transport and signaling and are also vital for membrane biogenesis. They have also been adapted to perform a diverse set of important cellular functions including acting as porins, transporters, enzymes, virulence factors and receptors. Recent structures of transmembrane β-barrels include that of a full length autotransporter (EstA), a bacterial heme transporter complex (HasR), a bacterial porin in complex with several ligands (PorB), and the mitochondrial voltage-dependent anion channel (VDAC) from both mouse and human. These represent only a few of the interesting structures of β-barrel membrane proteins recently elucidated. However, they demonstrate many of the advancements made within the field of transmembrane protein structure in the past few years. PMID:21719274

  17. 15 CFR 241.6 - Classes of barrels for tolerance application.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... FRUITS, VEGETABLES AND OTHER DRY COMMODITIES, AND FOR CRANBERRIES § 241.6 Classes of barrels for... other dry commodities other than cranberries, are hereby divided into two classes as follows: (a)...

  18. 15 CFR 241.6 - Classes of barrels for tolerance application.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... FRUITS, VEGETABLES AND OTHER DRY COMMODITIES, AND FOR CRANBERRIES § 241.6 Classes of barrels for... other dry commodities other than cranberries, are hereby divided into two classes as follows: (a)...

  19. 15 CFR 241.6 - Classes of barrels for tolerance application.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... FRUITS, VEGETABLES AND OTHER DRY COMMODITIES, AND FOR CRANBERRIES § 241.6 Classes of barrels for... other dry commodities other than cranberries, are hereby divided into two classes as follows: (a)...

  20. De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy

    PubMed Central

    Parmeggiani, Fabio; Velasco, D. Alejandro Fernandez; Höcker, Birte; Baker, David

    2015-01-01

    Despite efforts for over 25 years, de novo protein design has not succeeded in achieving the TIM-barrel fold. Here we describe the computational design of 4-fold symmetrical (β/α)8-barrels guided by geometrical and chemical principles. Experimental characterization of 33 designs revealed the importance of sidechain-backbone hydrogen bonding for defining the strand register between repeat units. The X-ray crystal structure of a designed thermostable 184-residue protein is nearly identical with the designed TIM-barrel model. PSI-BLAST searches do not identify sequence similarities to known TIM-barrel proteins, and sensitive profile-profile searches indicate that the design sequence is distant from other naturally occurring TIM-barrel superfamilies, suggesting that Nature has only sampled a subset of the sequence space available to the TIM-barrel fold. The ability to de novo design TIM-barrels opens new possibilities for custom-made enzymes. PMID:26595462

  1. Electroerosive wear of the barrel of a coaxial hybrid magnetoplasma accelerator in the acceleration of solids

    NASA Astrophysics Data System (ADS)

    Gerasimov, D. Yu.; Sivkov, A. A.

    2012-01-01

    The main regularities of electroerosive wear of the barrel of a hybrid coaxial magnetoplasma accelerator in the acceleration of solids are studied. In order to significantly reduce the erosive wear of the barrel without changing the dynamics of solid projectiles, a system of discharge shunting in the acceleration channel was used. It is shown that the plasma structure of a high-current arc discharge is fountain-shaped and its bridge consists of numerous discrete conduction channels.

  2. Yeast Mitochondria as a Model System to Study the Biogenesis of Bacterial β-Barrel Proteins.

    PubMed

    Ulrich, Thomas; Oberhettinger, Philipp; Autenrieth, Ingo B; Rapaport, Doron

    2015-01-01

    Beta-barrel proteins are found in the outer membrane of Gram-negative bacteria, mitochondria, and chloroplasts. The evolutionary conservation in the biogenesis of these proteins allows mitochondria to assemble bacterial β-barrel proteins in their functional form. In this chapter, we describe exemplarily how the capacity of yeast mitochondria to process the trimeric autotransporter YadA can be used to study the role of bacterial periplasmic chaperones in this process. PMID:26427673

  3. Level-1C Product from AIRS: Principal Component Filtering

    NASA Technical Reports Server (NTRS)

    Manning, Evan M.; Jiang, Yibo; Aumann, Hartmut H.; Elliott, Denis A.; Hannon, Scott

    2012-01-01

    The Atmospheric Infrared Sounder (AIRS), launched on the EOS Aqua spacecraft on May 4, 2002, is a grating spectrometer with 2378 channels in the range 3.7 to 15.4 microns. In a grating spectrometer each individual radiance measurement is largely independent of all others. Most measurements are extremely accurate and have very low noise levels. However, some channels exhibit high noise levels or other anomalous behavior, complicating applications needing radiances throughout a band, such as cross-calibration with other instruments and regression retrieval algorithms. The AIRS Level-1C product is similar to Level-1B but with instrument artifacts removed. This paper focuses on the "cleaning" portion of Level-1C, which identifies bad radiance values within spectra and produces substitute radiances using redundant information from other channels. The substitution is done in two passes, first with a simple combination of values from neighboring channels, then with principal components. After results of the substitution are shown, differences between principal component reconstructed values and observed radiances are used to investigate detailed noise characteristics and spatial misalignment in other channels.

  4. Academic performance and student engagement in level 1 physics undergraduates

    NASA Astrophysics Data System (ADS)

    Casey, M. M.; McVitie, S.

    2009-09-01

    At the beginning of academic year 2007-08, staff in the Department of Physics and Astronomy at the University of Glasgow started to implement a number of substantial changes to the administration of the level 1 physics undergraduate class. The main aims were to improve the academic performance and progression statistics. With this in mind, a comprehensive system of learning support was introduced, the main remit being the provision of an improved personal contact and academic monitoring and support strategy for all students at level 1. The effects of low engagement with compulsory continuous assessment components had already been observed to have a significant effect on students sitting in the middle of the grade curve. Analysis of data from the 2007-08 class showed that even some nominally high-achieving students achieved lowered grades due to the effects of low engagement. Nonetheless, academic and other support measures put in place during 2007-08 played a part in raising the passrate for the level 1 physics class by approximately 8% as well as raising the progression rate by approximately 10%.

  5. Characterization of a stalled complex on the β-barrel assembly machine.

    PubMed

    Lee, James; Xue, Mingyu; Wzorek, Joseph S; Wu, Tao; Grabowicz, Marcin; Gronenberg, Luisa S; Sutterlin, Holly A; Davis, Rebecca M; Ruiz, Natividad; Silhavy, Thomas J; Kahne, Daniel E

    2016-08-01

    The assembly of β-barrel proteins into membranes is mediated by an evolutionarily conserved machine. This process is poorly understood because no stable partially folded barrel substrates have been characterized. Here, we slowed the folding of the Escherichia coli β-barrel protein, LptD, with its lipoprotein plug, LptE. We identified a late-stage intermediate in which LptD is folded around LptE, and both components interact with the two essential β-barrel assembly machine (Bam) components, BamA and BamD. We propose a model in which BamA and BamD act in concert to catalyze folding, with the final step in the process involving closure of the ends of the barrel with release from the Bam components. Because BamD and LptE are both soluble proteins, the simplest model consistent with these findings is that barrel folding by the Bam complex begins in the periplasm at the membrane interface. PMID:27439868

  6. Evolutions of volatile sulfur compounds of Cabernet Sauvignon wines during aging in different oak barrels.

    PubMed

    Ye, Dong-Qing; Zheng, Xiao-Tian; Xu, Xiao-Qing; Wang, Yun-He; Duan, Chang-Qing; Liu, Yan-Lin

    2016-07-01

    The evolution of volatile sulfur compounds (VSCs) in Cabernet Sauvignon wines from seven regions of China during maturation in oak barrels was investigated. The barrels were made of different wood grains (fine and medium) and toasting levels (light and medium). Twelve VSCs were quantified by GC/FPD, with dimethyl sulfide (DMS) and methionol exceeding their sensory thresholds. Most VSCs tended to decline during the aging, while DMS was found to increase. After one year aging, the levels of DMS, 2-methyltetrahy-drothiophen-3-one and sulfur-containing esters were lower in the wines aged in oak barrels than in stainless steel tanks. The wood grain and toasting level of oak barrels significantly influenced the concentration of S-methyl thioacetate and 2-methyltetrahy-drothiophen-3-one. This study reported the evolution of VSCs in wines during oak barrel aging for the first time and evaluated the influence of barrel types, which would provide wine-makers with references in making proposals about wine aging. PMID:26920290

  7. Structural biology of membrane-intrinsic β-barrel enzymes: Sentinels of the bacterial outer membrane

    PubMed Central

    Bishop, Russell E.

    2016-01-01

    The outer membranes of Gram-negative bacteria are replete with integral membrane proteins that exhibit antiparallel β-barrel structures, but very few of these proteins function as enzymes. In Escherichia coli, only three β-barrel enzymes are known to exist in the outer membrane; these are the phospholipase OMPLA, the protease OmpT, and the phospholipid::lipid A palmitoyltransferase PagP, all of which have been characterized at the structural level. Structural details have also emerged for the outer membrane β-barrel enzyme PagL, a lipid A 3-O-deacylase from Pseudomonas aeruginosa. Lipid A can be further modified in the outer membrane by two β-barrel enzymes of unknown structure; namely, the Salmonella enterica 3′-acyloxyacyl hydrolase LpxR, and the Rhizobium leguminosarum oxidase LpxQ, which employs O2 to convert the proximal glucosamine unit of lipid A into 2-aminogluconate. Structural biology now indicates how β-barrel enzymes can function as sentinels that remain dormant when the outer membrane permeability barrier is intact. Host immune defenses and antibiotics that perturb this barrier can directly trigger β-barrel enzymes in the outer membrane. The ensuing adaptive responses occur instantaneously and rapidly outpace other signal transduction mechanisms that similarly function to restore the outer membrane permeability barrier. PMID:17880914

  8. The serotonin reuptake inhibitor citalopram suppresses activity in the neonatal rat barrel cortex in vivo.

    PubMed

    Akhmetshina, Dinara; Zakharov, Andrei; Vinokurova, Daria; Nasretdinov, Azat; Valeeva, Guzel; Khazipov, Roustem

    2016-06-01

    Inhibition of serotonin uptake, which causes an increase in extracellular serotonin levels, disrupts the development of thalamocortical barrel maps in neonatal rodents. Previous in vitro studies have suggested that the disruptive effect of excessive serotonin on barrel map formation involves a depression at thalamocortical synapses. However, the effects of serotonin uptake inhibitors on the early thalamocortical activity patterns in the developing barrel cortex in vivo remain largely unknown. Here, using extracellular recordings of the local field potentials and multiple unit activity (MUA) we explored the effects of the selective serotonin reuptake inhibitor (SSRI) citalopram (10-20mg/kg, intraperitoneally) on sensory evoked activity in the barrel cortex of neonatal (postnatal days P2-5) rats in vivo. We show that administration of citalopram suppresses the amplitude and prolongs the delay of the sensory evoked potentials, reduces the power and frequency of the early gamma oscillations, and suppresses sensory evoked and spontaneous neuronal firing. In the adolescent P21-29 animals, citalopram affected neither sensory evoked nor spontaneous activity in barrel cortex. We suggest that suppression of the early thalamocortical activity patterns contributes to the disruption of the barrel map development caused by SSRIs and other conditions elevating extracellular serotonin levels. PMID:27016034

  9. Quality control results of the drift tubes for the ATLAS MDT-BIS chambers

    NASA Astrophysics Data System (ADS)

    Alexopoulos, T.; Avramidou, R.; Dris, M.; Filippas, T. A.; Gazis, E. N.; Katsoufis, E.; Maltezos, S.; Savva, P.; Tsipolitis, G.; Tzamariudaki, E.

    2006-05-01

    ATLAS (A Toroidal LHC ApparatuS) is a general purpose experiment, which will start its operation at the Large Hadron Collider (LHC) at CERN in 2007. The ATLAS detector is designed to study the products of proton-proton collisions at c.m.s. energies of up to 14 TeV. Three Greek Universities have taken the responsibility to construct 112 BIS-MDT (Barrel Inner Small) chambers using 29 000 drift tubes of 170 cm length and 3 cm diameter that have been quality tested before assembly. This work describes the Quality Assurance and Quality Control (QA_QC) procedures for the drift tubes, followed at the High Energy Physics Laboratory of the National Technical University of Athens, while emphasis is given on the obtained results for the above mentioned number of tubes.

  10. ATLAS silicon microstrip tracker operation and performance

    NASA Astrophysics Data System (ADS)

    Barone, Gaetano

    2013-12-01

    The Semi-Conductor Tracker (SCT) is a silicon strip detector and one of the key precision tracking devices of the Inner Detector of the ATLAS experiment at CERN LHC. The SCT is constructed of 4088 silicon detector modules for a total of 6.3 million channels. Each module is designed, constructed and tested to operate as a stand-alone unit, mechanically, electrically, optically and thermally. The modules are mounted into two types of structures: one barrel (4 cylinders) and two end-cap systems (9 disks on each). The current results from the successful operation of the SCT Detector at the LHC and its status after three years of operation will be presented. The operation of the detector including an overview of the main issues encountered is reported. The main emphasis is given to the tracking performance of the SCT and the data quality during the >2 years of data taking of proton-proton collision data at 7 TeV (and short periods of heavy ion collisions). The SCT has been fully operational throughout all data taking periods, delivering high quality tracking data.

  11. Distributed analysis in ATLAS

    NASA Astrophysics Data System (ADS)

    Dewhurst, A.; Legger, F.

    2015-12-01

    The ATLAS experiment accumulated more than 140 PB of data during the first run of the Large Hadron Collider (LHC) at CERN. The analysis of such an amount of data is a challenging task for the distributed physics community. The Distributed Analysis (DA) system of the ATLAS experiment is an established and stable component of the ATLAS distributed computing operations. About half a million user jobs are running daily on DA resources, submitted by more than 1500 ATLAS physicists. The reliability of the DA system during the first run of the LHC and the following shutdown period has been high thanks to the continuous automatic validation of the distributed analysis sites and the user support provided by a dedicated team of expert shifters. During the LHC shutdown, the ATLAS computing model has undergone several changes to improve the analysis workflows, including the re-design of the production system, a new analysis data format and event model, and the development of common reduction and analysis frameworks. We report on the impact such changes have on the DA infrastructure, describe the new DA components, and include recent performance measurements.

  12. SENTINEL-2 Level 1 Products and Image Processing Performances

    NASA Astrophysics Data System (ADS)

    Baillarin, S. J.; Meygret, A.; Dechoz, C.; Petrucci, B.; Lacherade, S.; Tremas, T.; Isola, C.; Martimort, P.; Spoto, F.

    2012-07-01

    In partnership with the European Commission and in the frame of the Global Monitoring for Environment and Security (GMES) program, the European Space Agency (ESA) is developing the Sentinel-2 optical imaging mission devoted to the operational monitoring of land and coastal areas. The Sentinel-2 mission is based on a satellites constellation deployed in polar sun-synchronous orbit. While ensuring data continuity of former SPOT and LANDSAT multi-spectral missions, Sentinel-2 will also offer wide improvements such as a unique combination of global coverage with a wide field of view (290 km), a high revisit (5 days with two satellites), a high resolution (10 m, 20 m and 60 m) and multi-spectral imagery (13 spectral bands in visible and shortwave infra-red domains). In this context, the Centre National d'Etudes Spatiales (CNES) supports ESA to define the system image products and to prototype the relevant image processing techniques. This paper offers, first, an overview of the Sentinel-2 system and then, introduces the image products delivered by the ground processing: the Level-0 and Level-1A are system products which correspond to respectively raw compressed and uncompressed data (limited to internal calibration purposes), the Level-1B is the first public product: it comprises radiometric corrections (dark signal, pixels response non uniformity, crosstalk, defective pixels, restoration, and binning for 60 m bands); and an enhanced physical geometric model appended to the product but not applied, the Level-1C provides ortho-rectified top of atmosphere reflectance with a sub-pixel multi-spectral and multi-date registration; a cloud and land/water mask is associated to the product. Note that the cloud mask also provides an indication about cirrus. The ground sampling distance of Level-1C product will be 10 m, 20 m or 60 m according to the band. The final Level-1C product is tiled following a pre-defined grid of 100x100 km2, based on UTM/WGS84 reference frame. The

  13. Critical Design Decisions of The Planck LFI Level 1 Software

    NASA Astrophysics Data System (ADS)

    Morisset, N.; Rohlfs, R.; Türler, M.; Meharga, M.; Binko, P.; Beck, M.; Frailis, M.; Zacchei, A.

    2010-12-01

    The PLANCK satellite with two on-board instruments, a Low Frequency Instrument (LFI) and a High Frequency Instrument (HFI) has been launched on May 14th with Ariane 5. The ISDC Data Centre for Astrophysics in Versoix, Switzerland has developed and maintains the Planck LFI Level 1 software for the Data Processing Centre (DPC) in Trieste, Italy. The main tasks of the Level 1 processing are to retrieve the daily available scientific and housekeeping (HK) data of the LFI instrument, the Sorption Cooler and the 4k Cooler data from Mission Operation Centre (MOC) in Darmstadt; to sort them by time and by type (detector, observing mode, etc...); to extract the spacecraft attitude information from auxiliary files; to flag the data according to several criteria; and to archive the resulting Time Ordered Information (TOI), which will then be used to produce maps of the sky in different spectral bands. The output of the Level 1 software are the TOI files in FITS format, later ingested into the Data Management Component (DMC) database. This software has been used during different phases of the LFI instrument development. We started to reuse some ISDC components for the LFI Qualification Model (QM) and we completely rework the software for the Flight Model (FM). This was motivated by critical design decisions taken jointly with the DPC. The main questions were: a) the choice of the data format: FITS or DMC? b) the design of the pipelines: use of the Planck Process Coordinator (ProC) or a simple Perl script? c) do we adapt the existing QM software or do we restart from scratch? The timeline and available manpower are also important issues to be taken into account. We present here the orientation of our choices and discuss their pertinence based on the experience of the final pre-launch tests and the start of real Planck LFI operations.

  14. MODIS. Volume 1: MODIS level 1A software baseline requirements

    NASA Technical Reports Server (NTRS)

    Masuoka, Edward; Fleig, Albert; Ardanuy, Philip; Goff, Thomas; Carpenter, Lloyd; Solomon, Carl; Storey, James

    1994-01-01

    This document describes the level 1A software requirements for the moderate resolution imaging spectroradiometer (MODIS) instrument. This includes internal and external requirements. Internal requirements include functional, operational, and data processing as well as performance, quality, safety, and security engineering requirements. External requirements include those imposed by data archive and distribution systems (DADS); scheduling, control, monitoring, and accounting (SCMA); product management (PM) system; MODIS log; and product generation system (PGS). Implementation constraints and requirements for adapting the software to the physical environment are also included.

  15. Run 2 upgrades to the CMS Level-1 calorimeter trigger

    NASA Astrophysics Data System (ADS)

    Kreis, B.; Berryhill, J.; Cavanaugh, R.; Mishra, K.; Rivera, R.; Uplegger, L.; Apanasevich, L.; Zhang, J.; Marrouche, J.; Wardle, N.; Aggleton, R.; Ball, F.; Brooke, J.; Newbold, D.; Paramesvaran, S.; Smith, D.; Baber, M.; Bundock, A.; Citron, M.; Elwood, A.; Hall, G.; Iles, G.; Laner, C.; Penning, B.; Rose, A.; Tapper, A.; Foudas, C.; Beaudette, F.; Cadamuro, L.; Mastrolorenzo, L.; Romanteau, T.; Sauvan, J. B.; Strebler, T.; Zabi, A.; Barbieri, R.; Cali, I. A.; Innocenti, G. M.; Lee, Y.-J.; Roland, C.; Wyslouch, B.; Guilbaud, M.; Li, W.; Northup, M.; Tran, B.; Durkin, T.; Harder, K.; Harper, S.; Shepherd-Themistocleous, C.; Thea, A.; Williams, T.; Cepeda, M.; Dasu, S.; Dodd, L.; Forbes, R.; Gorski, T.; Klabbers, P.; Levine, A.; Ojalvo, I.; Ruggles, T.; Smith, N.; Smith, W.; Svetek, A.; Tikalsky, J.; Vicente, M.

    2016-01-01

    The CMS Level-1 calorimeter trigger is being upgraded in two stages to maintain performance as the LHC increases pile-up and instantaneous luminosity in its second run. In the first stage, improved algorithms including event-by-event pile-up corrections are used. New algorithms for heavy ion running have also been developed. In the second stage, higher granularity inputs and a time-multiplexed approach allow for improved position and energy resolution. Data processing in both stages of the upgrade is performed with new, Xilinx Virtex-7 based AMC cards.

  16. Atlas Regeneration, Inc.

    PubMed

    Makarev, Eugene; Isayev, Olexandr; Atala, Anthony

    2016-03-01

    Atlas Regeneration is dedicated to the development of novel data-driven solutions for regenerative medicine, adapting proven technologies, and analysis strategies to take a multiomics-wide view of stem cell quality and cell fate design. Our core offering is a global comprehensive map of stem cell differentiation, Universal Signalome Atlas for Regenerative Medicine, reflecting the pathway activation states across all characterized stem cells and their differentiated products. Key applications of Universal Signalome Atlas for Regenerative Medicine will include quality assurance for engineered cell products, and directed regeneration pharmacology, where we will screen and identify compounds that can efficiently convert pluripotent cells into desired subtypes. Another marketable piece of IP is development of specialized signaling pathway analysis systems Regeneration Intelligence which supposed to target the unmet needs of determination and prediction of stem cell signaling pathway activation to govern cell differentiation in specific directions. PMID:26925598

  17. Calorimetry Triggering in ATLAS

    SciTech Connect

    Igonkina, O.; Achenbach, R.; Adragna, P.; Aharrouche, M.; Alexandre, G.; Andrei, V.; Anduaga, X.; Aracena, I.; Backlund, S.; Baines, J.; Barnett, B.M.; Bauss, B.; Bee, C.; Behera, P.; Bell, P.; Bendel, M.; Benslama, K.; Berry, T.; Bogaerts, A.; Bohm, C.; Bold, T.; /UC, Irvine /AGH-UST, Cracow /Birmingham U. /Barcelona, IFAE /CERN /Birmingham U. /Rutherford /Montreal U. /Santa Maria U., Valparaiso /DESY /DESY, Zeuthen /Geneva U. /City Coll., N.Y. /Barcelona, IFAE /CERN /Birmingham U. /Kirchhoff Inst. Phys. /Birmingham U. /Lisbon, LIFEP /Rio de Janeiro Federal U. /City Coll., N.Y. /Birmingham U. /Copenhagen U. /Copenhagen U. /Brookhaven /Rutherford /Royal Holloway, U. of London /Pennsylvania U. /Montreal U. /SLAC /CERN /Michigan State U. /Chile U., Catolica /City Coll., N.Y. /Oxford U. /La Plata U. /McGill U. /Mainz U., Inst. Phys. /Hamburg U. /DESY /DESY, Zeuthen /Geneva U. /Queen Mary, U. of London /CERN /Rutherford /Rio de Janeiro Federal U. /Birmingham U. /Montreal U. /CERN /Kirchhoff Inst. Phys. /Liverpool U. /Royal Holloway, U. of London /Pennsylvania U. /Kirchhoff Inst. Phys. /Geneva U. /Birmingham U. /NIKHEF, Amsterdam /Rutherford /Royal Holloway, U. of London /Rutherford /Royal Holloway, U. of London /AGH-UST, Cracow /Mainz U., Inst. Phys. /Mainz U., Inst. Phys. /Birmingham U. /Hamburg U. /DESY /DESY, Zeuthen /Geneva U. /Kirchhoff Inst. Phys. /Michigan State U. /Stockholm U. /Stockholm U. /Birmingham U. /CERN /Montreal U. /Stockholm U. /Arizona U. /Regina U. /Regina U. /Rutherford /NIKHEF, Amsterdam /Kirchhoff Inst. Phys. /DESY /DESY, Zeuthen /City Coll., N.Y. /University Coll. London /Humboldt U., Berlin /Queen Mary, U. of London /Argonne /LPSC, Grenoble /Arizona U. /Kirchhoff Inst. Phys. /Birmingham U. /Antonio Narino U. /Hamburg U. /DESY /DESY, Zeuthen /Kirchhoff Inst. Phys. /Birmingham U. /Chile U., Catolica /Indiana U. /Manchester U. /Kirchhoff Inst. Phys. /Rutherford /City Coll., N.Y. /Stockholm U. /La Plata U. /Antonio Narino U. /Queen Mary, U. of London /Kirchhoff Inst. Phys. /Antonio Narino U. /Pavia U. /City Coll., N.Y. /Mainz U., Inst. Phys. /Mainz U., Inst. Phys. /Pennsylvania U. /Barcelona, IFAE /Barcelona, IFAE /Chile U., Catolica /Genoa U. /INFN, Genoa /Rutherford /Barcelona, IFAE /Nevis Labs, Columbia U. /CERN /Antonio Narino U. /McGill U. /Rutherford /Santa Maria U., Valparaiso /Rutherford /Chile U., Catolica /Brookhaven /Oregon U. /Mainz U., Inst. Phys. /Barcelona, IFAE /McGill U. /Antonio Narino U. /Antonio Narino U. /Kirchhoff Inst. Phys. /Sydney U. /Rutherford /McGill U. /McGill U. /Pavia U. /Genoa U. /INFN, Genoa /Kirchhoff Inst. Phys. /Kirchhoff Inst. Phys. /Mainz U., Inst. Phys. /Barcelona, IFAE /SLAC /Stockholm U. /Moscow State U. /Stockholm U. /Birmingham U. /Kirchhoff Inst. Phys. /DESY /DESY, Zeuthen /Birmingham U. /Geneva U. /Oregon U. /Barcelona, IFAE /University Coll. London /Royal Holloway, U. of London /Birmingham U. /Mainz U., Inst. Phys. /Birmingham U. /Birmingham U. /Oregon U. /La Plata U. /Geneva U. /Chile U., Catolica /McGill U. /Pavia U. /Barcelona, IFAE /Regina U. /Birmingham U. /Birmingham U. /Kirchhoff Inst. Phys. /Oxford U. /CERN /Kirchhoff Inst. Phys. /UC, Irvine /UC, Irvine /Wisconsin U., Madison /Rutherford /Mainz U., Inst. Phys. /CERN /Geneva U. /Copenhagen U. /City Coll., N.Y. /Wisconsin U., Madison /Rio de Janeiro Federal U. /Wisconsin U., Madison /Stockholm U. /University Coll. London

    2011-12-08

    The ATLAS experiment is preparing for data taking at 14 TeV collision energy. A rich discovery physics program is being prepared in addition to the detailed study of Standard Model processes which will be produced in abundance. The ATLAS multi-level trigger system is designed to accept one event in 2/10{sup 5} to enable the selection of rare and unusual physics events. The ATLAS calorimeter system is a precise instrument, which includes liquid Argon electro-magnetic and hadronic components as well as a scintillator-tile hadronic calorimeter. All these components are used in the various levels of the trigger system. A wide physics coverage is ensured by inclusively selecting events with candidate electrons, photons, taus, jets or those with large missing transverse energy. The commissioning of the trigger system is being performed with cosmic ray events and by replaying simulated Monte Carlo events through the trigger and data acquisition system.

  18. Multiple brain atlas database and atlas-based neuroimaging system.

    PubMed

    Nowinski, W L; Fang, A; Nguyen, B T; Raphel, J K; Jagannathan, L; Raghavan, R; Bryan, R N; Miller, G A

    1997-01-01

    For the purpose of developing multiple, complementary, fully labeled electronic brain atlases and an atlas-based neuroimaging system for analysis, quantification, and real-time manipulation of cerebral structures in two and three dimensions, we have digitized, enhanced, segmented, and labeled the following print brain atlases: Co-Planar Stereotaxic Atlas of the Human Brain by Talairach and Tournoux, Atlas for Stereotaxy of the Human Brain by Schaltenbrand and Wahren, Referentially Oriented Cerebral MRI Anatomy by Talairach and Tournoux, and Atlas of the Cerebral Sulci by Ono, Kubik, and Abernathey. Three-dimensional extensions of these atlases have been developed as well. All two- and three-dimensional atlases are mutually preregistered and may be interactively registered with an actual patient's data. An atlas-based neuroimaging system has been developed that provides support for reformatting, registration, visualization, navigation, image processing, and quantification of clinical data. The anatomical index contains about 1,000 structures and over 400 sulcal patterns. Several new applications of the brain atlas database also have been developed, supported by various technologies such as virtual reality, the Internet, and electronic publishing. Fusion of information from multiple atlases assists the user in comprehensively understanding brain structures and identifying and quantifying anatomical regions in clinical data. The multiple brain atlas database and atlas-based neuroimaging system have substantial potential impact in stereotactic neurosurgery and radiotherapy by assisting in visualization and real-time manipulation in three dimensions of anatomical structures, in quantitative neuroradiology by allowing interactive analysis of clinical data, in three-dimensional neuroeducation, and in brain function studies. PMID:9148878

  19. Evaluation of the breakdown behaviour of ATLAS silicon pixel sensors after partial guard-ring removal

    NASA Astrophysics Data System (ADS)

    Goessling, C.; Klingenberg, R.; Muenstermann, D.; Wittig, T.

    2010-12-01

    To avoid geometrical inefficiencies in the ATLAS pixel detector, the concept of shingling is used up to now in the barrel section. For the upgrades of ATLAS, it is desired to avoid this as it increases the volume and material budget of the pixel layers and complicates the cooling. A direct planar edge-to-edge arrangement of pixel modules has not been possible in the past due to about 1100 μm of inactive edge composed of approximately 600 μm of guard rings and 500 μm of safety margin. In this work, the safety margin and guard rings of ATLAS SingleChip sensors were cut at different positions using a standard diamond dicing saw and irradiated afterwards to explore the breakdown behaviour and the leakage current development. It is found that the inactive edge can be reduced to about 400 μm of guard rings with almost no reduction in pre-irradiation testability and leakage current performance. This is in particular important for the insertable b-layer upgrade of ATLAS (IBL) where inactive edges of less than 450 μm width are required.

  20. The Herschel ATLAS

    NASA Technical Reports Server (NTRS)

    Eales, S.; Dunne, L.; Clements, D.; Cooray, A.; De Zotti, G.; Dye, S.; Ivison, R.; Jarvis, M.; Lagache, G.; Maddox, S.; Negrello, M.; Serjeant, S.; Thompson, M. A.; Van Kampen, E.; Amblard, A.; Andreani, P.; Baes, M.; Beelen, A.; Bendo, G. J.; Bertoldi, F.; Benford, D.; Bock, J.

    2010-01-01

    The Herschel ATLAS is the largest open-time key project that will be carried out on the Herschel Space Observatory. It will survey 570 sq deg of the extragalactic sky, 4 times larger than all the other Herschel extragalactic surveys combined, in five far-infrared and submillimeter bands. We describe the survey, the complementary multiwavelength data sets that will be combined with the Herschel data, and the six major science programs we are undertaking. Using new models based on a previous submillimeter survey of galaxies, we present predictions of the properties of the ATLAS sources in other wave bands.

  1. System design and performances of ASTER Level-1 data processing

    NASA Astrophysics Data System (ADS)

    Nishida, Sumiyuki; Hachiya, Jun; Matsumoto, Ken; Fujisada, Hiroyuki; Kato, Masatane

    1998-12-01

    ASTER is a multispectral imager which covers wide spectral region from visible to thermal infrared with 14 spectral bands, and will fly on EOS-AM1 in 1999. To meet this wide spectral coverage, ASTER has three optical sensing subsystems (multi-telescope system), VNIR, SWIR and TIR. This multi- telescope configuration requires highly refined ground processing for the generation of Level-1 data products that are radiometrically calibrated and geometrically corrected. A prototype Level-1 processing software system is developed to satisfy these requirements. System design concept adopted includes; (1) 'Automatic Processing,' (2)'ALL-IN-ONE-CONCEPT' in which the processing is carried out using information included in Level-0 data product only, (3) 'MODULE INDEPENDENCE' in which only process control module independently control other modules to change any operational conditions. (4) 'FLEXIBILITY' in which important operation parameters are set from an external component to make the processing condition change easier. The adaptability and the performance of the developed software system are evaluated using simulation data.

  2. Hazardous materials readiness of United States level 1 trauma centers.

    PubMed

    Ghilarducci, D P; Pirrallo, R G; Hegmann, K T

    2000-07-01

    Injuries caused by hazardous materials (hazmat) accidents are common in the United States, and emergency departments should be capable of decontaminating these patients. There are, however, no national studies that assess emergency department preparedness. The purpose of this survey was to assess the hazmat readiness of US Level 1 trauma centers (TCs). All 1996 Hospital Blue Book TCs (256) were queried by anonymous survey; 61% (156) responded to the survey. The TCs treated 43,046 +/- 28,455 patients (median, 40,500; range, 600 to 220,000); 15 +/- 29 (median, 6; range, 0 to 200) were hazmat-contaminated. Only 6% acknowledged having all necessary equipment required for safe decontamination. Many (83%) had hazmat response plans, but few (30%) of these plans were complete. Approximately 36% of the staff had received training. Thirteen staff required medical attention themselves after rendering care to a contaminated patient. Only 58% of the TCs performed a single drill. The preparedness of US Level 1 TCs to safely decontaminate hazmat patients seems to be inadequate. PMID:10914337

  3. Autotransporter structure reveals intra-barrel cleavage followed by conformational changes

    PubMed Central

    Barnard, Travis J.; Dautin, Nathalie; Lukacik, Petra; Bernstein, Harris D.; Buchanan, Susan K.

    2008-01-01

    Autotransporters are virulence factors produced by Gram-negative bacteria that consist of two domains, an N-terminal “passenger domain” and a C-terminal “β-domain”. β-domains form β-barrel structures in the outer membrane while passenger domains are translocated into the extracellular space. In some autotransporters, the two domains are separated by proteolytic cleavage. Using X-ray crystallography, we solved the 2.7 Å structure of the post-cleavage state of the β-domain of EspP, an autotransporter produced by E. coli O157:H7. The structure consists of a 12-stranded β-barrel with the passenger / β-domain cleavage junction located inside the barrel pore, approximately mid-way between the extracellular and periplasmic surfaces of the outer membrane. The structure reveals an unprecedented intra-barrel cleavage mechanism and suggests that two conformational changes occur in the β-domain post-cleavage, one conferring increased stability on the β-domain and another restricting access to the barrel pore. PMID:17994105

  4. Assembly of a Full-Scale External Tank Barrel Section Using Friction Stir Welding

    NASA Technical Reports Server (NTRS)

    Jones, Chip; Adams, Glynn

    1999-01-01

    A full-scale pathfinder barrel section of the External Tank for the National Aeronautics and Space Administration (NASA) Space Transport System (Space Shuttle) has been assembled at Marshall Space Flight Center (MSFC) via a collaborative effort between NASA/MSFC and Lockheed Martin Michoud Space Systems. The barrel section is 27.5 feet in diameter and 15 feet in height. The barrel was assembled using Super-Light-Weight (SLWT), orthogrid, Al-Li 2195 panel sections and a single longeron panel. A vertical weld tool at MSFC was modified to accommodate FSW and used to assemble the barrel. These modifications included the addition of a FSW weld head and new controller hardware and software, the addition of a backing anvil and the replacement of the clamping system with individually actuated clamps. Weld process 4evelopment was initially conducted to optimize the process for the welds required for completing the assembly. The variable thickness welds in the longeron section were conducted via both two-sided welds and with the use of a retractable pin tool. The barrel assembly was completed in October 1998. Details of the vertical weld tool modifications and the assembly process are presented.

  5. Unusual mode of firearm injury from the recoiled rear end of a gun barrel.

    PubMed

    Agrawal, A; Malla, G; Joshi, S; Kumar, A; Koirala, S

    2008-09-01

    Atypical gunshot wounds are caused by a diverse set of parameters relating to weapons and ammunition. We report a previously-unreported and atypical mode of gunshot wound produced by a detached rear end of the barrel of a gun following accidental gun fire, and discuss the difficulties in the management. A 36-year-old man presented to the emergency department with an alleged history of injury on the forehead with the rear end of a gun barrel following accidental gunfire while cleaning the nozzle. Since the time of injury, the patient was in an altered sensorium and had weakness on the right side of the body. There was minimal but continuous bleeding from the wound, with extrusion of brain matter. Skull radiograph showed that the rear end of the barrel had entered the left frontal bone, with associated depressed fracture of the frontal bone. The patient underwent a bicoronal, bifrontal craniotomy with a T-shaped extension towards the barrel to facilitate the reflection of the scalp flap and to avoid any movement of the barrel as it might further injure the brain. Necrotic brain, dura and bone pieces were removed. The patient was doing well at follow-up except for mild residual motor deficits. This case illustrates that while working with limited facilities, particularly in underdeveloped countries, a careful clinical assessment, interpretation of available images and a judicious operative approach can help to save the patient. PMID:18830529

  6. Angular tuning and velocity sensitivity in different neuron classes within layer 4 of rat barrel cortex.

    PubMed

    Lee, Soo-Hyun; Simons, Daniel J

    2004-01-01

    Local circuitry within layer IV whisker-related barrels is preferentially sensitive to thalamic population firing synchrony, and neurons respond most vigorously to stimuli, such as high-velocity whisker deflections, that evoke it. Field potential recordings suggest that thalamic barreloid neurons having similar angular preferences fire synchronously. To examine whether angular tuning of cortical neurons might also be affected by thalamic firing synchrony, we characterized responses of layer IV units to whisker deflections that varied in angular direction and velocity. Barrel regular-spike units (RSUs) became more tuned for deflection angle with slower whisker movements. Deflection amplitude had no affect. Barrel fast-spike units (FSUs) were poorly tuned for deflection angle, and their responses remained constant with different deflection velocity. The dependence of angular tuning on deflection velocity among barrel RSUs appears to reflect the same underlying response dynamics that determine their velocity sensitivity and receptive field focus. Unexpectedly, septal RSUs and FSUs are largely similar to their barrel counterparts despite available evidence suggesting that they receive different afferent inputs and are embedded within different local circuits. PMID:14507984

  7. The ATLAS SCT endcap: From module production to commissioning

    NASA Astrophysics Data System (ADS)

    Ferrère, D.

    2007-01-01

    The ATLAS experiment at the Large Hadron Collider (LHC) at CERN is aiming for new physics at TeV scale energy and will be operational in 2007. The Semiconductor Tracker (SCT) is a part of the ATLAS Inner Detector (ID) and consists of 4088 silicon detector modules displayed on four concentric barrels and two endcaps on each side. Almost 2400 endcap modules have been produced in seven assembly sites including a 20% contingency. All the qualified modules have been shipped to the two macro-assembly sites where the modules are now mounted to the discs. A major organizational effort around the components and the logistics has been made to ensure that the project is running with a high yield and within the schedule. Well defined and strict quality assurance rules allowed the endcap community to achieve an average production yield of 92.9%. In order to complete the two endcaps, a major effort is made for finalizing the assembly of modules and services onto the discs and carbon fiber cylinder, respectively. After describing the organization of the endcap module assembly and the production results, a description and status of the endcap macro-assembly and services will be reported.

  8. BOREAS AFM-5 Level-1 Upper Air Network Data

    NASA Technical Reports Server (NTRS)

    Barr, Alan; Hrynkiw, Charmaine; Newcomer, Jeffrey A. (Editor); Hall, Forrest G. (Editor); Smith, David E. (Technical Monitor)

    2000-01-01

    The Boreal Ecosystem-Atmosphere Study (BOREAS) Airborne Fluxes and Meteorology (AFM)-5 team collected and processed data from the numerous radiosonde flights during the project. The goals of the AFM-05 team were to provide large-scale definition of the atmosphere by supplementing the existing Atmospheric Environment Service (AES) aerological network, both temporally and spatially. This data set includes basic upper-air parameters collected from the network of upper-air stations during the 1993, 1994, and 1996 field campaigns over the entire study region. The data are contained in tabular ASCII files. The level-1 upper-air network data are available from the Earth Observing System Data and Information System (EOSDIS) Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC). The data files also are available on a CD-ROM (see document number 20010000884).

  9. EOS MLS Level 1B Data Processing Software. Version 3

    NASA Technical Reports Server (NTRS)

    Perun, Vincent S.; Jarnot, Robert F.; Wagner, Paul A.; Cofield, Richard E., IV; Nguyen, Honghanh T.; Vuu, Christina

    2011-01-01

    This software is an improvement on Version 2, which was described in EOS MLS Level 1B Data Processing, Version 2.2, NASA Tech Briefs, Vol. 33, No. 5 (May 2009), p. 34. It accepts the EOS MLS Level 0 science/engineering data, and the EOS Aura spacecraft ephemeris/attitude data, and produces calibrated instrument radiances and associated engineering and diagnostic data. This version makes the code more robust, improves calibration, provides more diagnostics outputs, defines the Galactic core more finely, and fixes the equator crossing. The Level 1 processing software manages several different tasks. It qualifies each data quantity using instrument configuration and checksum data, as well as data transmission quality flags. Statistical tests are applied for data quality and reasonableness. The instrument engineering data (e.g., voltages, currents, temperatures, and encoder angles) is calibrated by the software, and the filter channel space reference measurements are interpolated onto the times of each limb measurement with the interpolates being differenced from the measurements. Filter channel calibration target measurements are interpolated onto the times of each limb measurement, and are used to compute radiometric gain. The total signal power is determined and analyzed by each digital autocorrelator spectrometer (DACS) during each data integration. The software converts each DACS data integration from an autocorrelation measurement in the time domain into a spectral measurement in the frequency domain, and estimates separately the spectrally, smoothly varying and spectrally averaged components of the limb port signal arising from antenna emission and scattering effects. Limb radiances are also calibrated.

  10. SENTINEL-2 image quality and level 1 processing

    NASA Astrophysics Data System (ADS)

    Meygret, Aimé; Baillarin, Simon; Gascon, Ferran; Hillairet, Emmanuel; Dechoz, Cécile; Lacherade, Sophie; Martimort, Philippe; Spoto, François; Henry, Patrice; Duca, Riccardo

    2009-08-01

    In the framework of the Global Monitoring for Environment and Security (GMES) programme, the European Space Agency (ESA) in partnership with the European Commission (EC) is developing the SENTINEL-2 optical imaging mission devoted to the operational monitoring of land and coastal areas. The Sentinel-2 mission is based on a twin satellites configuration deployed in polar sun-synchronous orbit and is designed to offer a unique combination of systematic global coverage with a wide field of view (290km), a high revisit (5 days at equator with two satellites), a high spatial resolution (10m, 20m and 60 m) and multi-spectral imagery (13 bands in the visible and the short wave infrared spectrum). SENTINEL-2 will ensure data continuity of SPOT and LANDSAT multispectral sensors while accounting for future service evolution. This paper presents the main geometric and radiometric image quality requirements for the mission. The strong multi-spectral and multi-temporal registration requirements constrain the stability of the platform and the ground processing which will automatically refine the geometric physical model through correlation technics. The geolocation of the images will take benefits from a worldwide reference data set made of SENTINEL-2 data strips geolocated through a global space-triangulation. These processing are detailed through the description of the level 1C production which will provide users with ortho-images of Top of Atmosphere reflectances. The huge amount of data (1.4 Tbits per orbit) is also a challenge for the ground processing which will produce at level 1C all the acquired data. Finally we discuss the different geometric (line of sight, focal plane cartography, ...) and radiometric (relative and absolute camera sensitivity) in-flight calibration methods that will take advantage of the on-board sun diffuser and ground targets to answer the severe mission requirements.

  11. Big Sky Carbon Atlas

    DOE Data Explorer

    The Big Sky Carbon Atlas is an online geoportal designed for you to discover, interpret, and access geospatial data and maps relevant to decision support and education on carbon sequestration in the Big Sky Region. In serving as the public face of the Partnership's spatial Data Libraries, the Atlas provides a gateway to geographic information characterizing CO2 sources, potential geologic sinks, terrestrial carbon fluxes, civil and energy infrastructure, energy use, and related themes. In addition to directly serving the BSCSP and its stakeholders, the Atlas feeds regional data to the NatCarb Portal, contributing to a national perspective on carbon sequestration. Established components of the Atlas include a gallery of thematic maps and an interactive map that allows you to: • Navigate and explore regional characterization data through a user-friendly interface • Print your map views or publish them as PDFs • Identify technical references relevant to specific areas of interest • Calculate straight-line or pipeline-constrained distances from point sources of CO2 to potential geologic sink features • Download regional data layers (feature under development) (Acknowledgment to the Big Sky Carbon Sequestration Partnership (BSCSP); see home page at http://www.bigskyco2.org/)

  12. An Icelandic wind atlas

    NASA Astrophysics Data System (ADS)

    Nawri, Nikolai; Nína Petersen, Gudrun; Bjornsson, Halldór; Arason, Þórður; Jónasson, Kristján

    2013-04-01

    While Iceland has ample wind, its use for energy production has been limited. Electricity in Iceland is generated from renewable hydro- and geothermal source and adding wind energy has not be considered practical or even necessary. However, adding wind into the energy mix is becoming a more viable options as opportunities for new hydro or geothermal power installation become limited. In order to obtain an estimate of the wind energy potential of Iceland a wind atlas has been developed as a part of the Nordic project "Improved Forecast of Wind, Waves and Icing" (IceWind). The atlas is based on mesoscale model runs produced with the Weather Research and Forecasting (WRF) Model and high-resolution regional analyses obtained through the Wind Atlas Analysis and Application Program (WAsP). The wind atlas shows that the wind energy potential is considerable. The regions with the strongest average wind are nevertheless impractical for wind farms, due to distance from road infrastructure and power grid as well as harsh winter climate. However, even in easily accessible regions wind energy potential in Iceland, as measured by annual average power density, is among the highest in Western Europe. There is a strong seasonal cycle, with wintertime power densities throughout the island being at least a factor of two higher than during summer. Calculations show that a modest wind farm of ten medium size turbines would produce more energy throughout the year than a small hydro power plants making wind energy a viable additional option.

  13. Atlas of NATO.

    ERIC Educational Resources Information Center

    Young, Harry F.

    This atlas provides basic information about the North Atlantic Treaty Organization (NATO). Formed in response to growing concern for the security of Western Europe after World War II, NATO is a vehicle for Western efforts to reduce East-West tensions and the level of armaments. NATO promotes political and economic collaboration as well as military…

  14. Distributed Wireless Monitoring System for Ullage and Temperature in Wine Barrels.

    PubMed

    Zhang, Wenqi; Skouroumounis, George K; Monro, Tanya M; Taylor, Dennis

    2015-01-01

    This paper presents a multipurpose and low cost sensor for the simultaneous monitoring of temperature and ullage of wine in barrels in two of the most important stages of winemaking, that being fermentation and maturation. The distributed sensor subsystem is imbedded within the bung of the barrel and runs on battery for a period of at least 12 months and costs around $27 AUD for all parts. In addition, software was designed which allows for the remote transmission and easy visual interpretation of the data for the winemaker. Early warning signals can be sent when the temperature or ullage deviates from a winemakers expectations so remedial action can be taken, such as when topping is required or the movement of the barrels to a cooler cellar location. Such knowledge of a wine's properties or storage conditions allows for a more precise control of the final wine quality. PMID:26266410

  15. A novel open-barrel structure of octameric translin reveals a potential RNA entryway.

    PubMed

    Eliahoo, Elad; Marx, Ailie; Manor, Haim; Alian, Akram

    2015-02-27

    The single-stranded DNA (ssDNA)/RNA binding protein translin was suggested to be involved in chromosomal translocations, telomere metabolism, and mRNA transport and translation. Oligonucleotide binding surfaces map within a closed cavity of translin octameric barrels, raising the question as to how DNA/RNA gain access to this inner cavity, particularly given that, to date, none of the barrel structures reported hint to an entryway. Here, we argue against a mechanism by which translin octamers may "dissociate and reassemble" upon RNA binding and report a novel "open"-barrel structure of human translin revealing a feasible DNA/RNA entryway into the cavity. Additionally, we report that translin not only is confined to binding of ssDNA oligonucleotides, or single-stranded extensions of double-stranded DNA (dsDNA), but also can bind single-stranded sequences internally embedded in dsDNA molecules. PMID:25433126

  16. [Automatic polishing of dental prostheses. 1. Development of a centrifugal barrel finishing apparatus].

    PubMed

    Tamaki, Y; Miyazaki, T; Aoyama, N; Suzuki, E; Miyaji, T

    1990-09-01

    A centrifugal barrel finishing apparatus with a variable turn table rotational speed (250-1,000 rpm) was newly developed and barrel finishing of Ni-Cr casting plates (10 x 10 x 2 mm) was performed using alumina base chips. When using the sample with a mirror face the amount of polishing and the surface roughness increased and the surface gloss decreased with the increase in rotation speed. A high rotational speed was useful for coarse polishing and low rotational speed was useful for fine polishing. The continuous barrel polishing was trially performed using the sample prepared by the carborundum wheel under variable rotational speed. Automatic polishing to fine polishing could be done using this apparatus. PMID:2133366

  17. Distributed Wireless Monitoring System for Ullage and Temperature in Wine Barrels

    PubMed Central

    Zhang, Wenqi; Skouroumounis, George K.; Monro, Tanya M.; Taylor, Dennis K.

    2015-01-01

    This paper presents a multipurpose and low cost sensor for the simultaneous monitoring of temperature and ullage of wine in barrels in two of the most important stages of winemaking, that being fermentation and maturation. The distributed sensor subsystem is imbedded within the bung of the barrel and runs on battery for a period of at least 12 months and costs around $27 AUD for all parts. In addition, software was designed which allows for the remote transmission and easy visual interpretation of the data for the winemaker. Early warning signals can be sent when the temperature or ullage deviates from a winemakers expectations so remedial action can be taken, such as when topping is required or the movement of the barrels to a cooler cellar location. Such knowledge of a wine’s properties or storage conditions allows for a more precise control of the final wine quality. PMID:26266410

  18. Design and fabrication of an advanced, lightweight, high stiffness, railgun barrel concept

    SciTech Connect

    Vrable, D.L.; Rosenwasser, S.N.; Korican, J.A. )

    1991-01-01

    An advanced lightweight and high stiffness railgun barrel design and incorporates several new design features and advanced materials is being developed by SPARTA, Inc. The program is sponsored by the U.S. Army Armament Research, Development, and Engineering Center ARDEC and by the Defense Advanced Research Projects Agency (DARPA). The railgun is 7 m long and has a 90 mm round bore. It is designed to accommodate both solid and plasma armatures. Muzzle energies are expected in the range of 9 to 15 MJ. Analysis and final design has been completed and the barrel and other railgun subassemblies are in the fabrication stage at SPARTA, Inc. in San Diego, California. Initial testing will be conducted at Maxwell Laboratories Green Farm facility in September 1990 and will subsequently be shipped to the ARDEC Railgun Laboratory in October 1990 for full power operation and testing. This paper discusses the design features and fabrication approaches for this high performance, lightweight railgun barrel system.

  19. Beta-Barrel Scaffold of Fluorescent Proteins: Folding, Stability and Role in Chromophore Formation

    PubMed Central

    Stepanenko, Olesya V.; Stepanenko, Olga V.; Kuznetsova, Irina M.; Verkhusha, Vladislav V.; Turoverov, Konstantin K.

    2013-01-01

    This review focuses on the current view of the interaction between the β-barrel scaffold of fluorescent proteins and their unique chromophore located in the internal helix. The chromophore originates from the polypeptide chain and its properties are influenced by the surrounding protein matrix of the β-barrel. On the other hand, it appears that a chromophore tightens the β-barrel scaffold and plays a crucial role in its stability. Furthermore, the presence of a mature chromophore causes hysteresis of protein unfolding and refolding. We survey studies measuring protein unfolding and refolding using traditional methods as well as new approaches, such as mechanical unfolding and reassembly of truncated fluorescent proteins. We also analyze models of fluorescent protein unfolding and refolding obtained through different approaches, and compare the results of protein folding in vitro to co-translational folding of a newly synthesized polypeptide chain. PMID:23351712

  20. Quantitative/Statistical Approach to Bullet-to-Firearm Identification with Consecutively Manufactured Barrels

    SciTech Connect

    Peter Striupaitis; R.E. Gaensslen

    2005-01-30

    Efforts to use objective image comparison and bullet scanning technologies to distinguish bullets from consecutively manufactured handgun barrels from two manufacturers gave mixed results. The ability of a technology to reliably distinguish between matching and non-matching bullets, where the non-matching bullets were as close in pattern to the matching ones as is probably possible, would provide evidence that the distinctions could be made ''objectively'', and independently of human eyes. That evidence is identical or very close to what seems to be needed to satisfy Daubert standards. It is fair to say that the FTI IBIS image comparison technology correctly distinguished between all the Springfield barrel bullets, and between most but not all of the HiPoint barrel bullets. In the HiPoint cases that were not distinguished 100% of the time, they would he distinguished correctly at least 83% of the time. These results, although obviously limited to the materials used in the comparisons, provide strong evidence that barrel-to-bullet matching is objectively reliable. The results with SciClops were less compelling. The results do not mean that bullet-to-barrel matching is not objectively reliable--rather, they mean that this version of the particular technology could not quite distinguish between these extremely similar yet different bullets as well as the image comparison technology did. In a number of cases, the numerical results made the correct distinctions, although they were close to one another. It is hard to say from this data that this technology differs in its ability to make distinctions between the manufacturers, because the results are very similar with both. The human examiner results were as expected. We did not expect any misidentifications, and there were not any. It would have been preferable to have a higher return rate, and thus more comparisons in the overall sample. As noted, the ''consecutively manufactured barrel exercise'' has been done before

  1. Developmental and comparative aspects of posterior medial thalamocortical innervation of barrel cortex in mice and rats

    PubMed Central

    Kichula, Elizabeth A.; Huntley, George W.

    2016-01-01

    The thalamocortical projection to rodent barrel cortex consists of inputs from the ventral posterior medial (VPM) and posterior medial (POm) nuclei that terminate in largely non-overlapping territories in and outside of layer IV. This projection in both rats and mice has been used extensively to study development and plasticity of highly-organized synaptic circuits. Whereas the VPM pathway has been well characterized in both rats and mice, organization of the POm pathway has only been described in rats, and no studies have focused exclusively on the development of the POm projection. Here, using transport of PHA-L or carbocyanine dyes, we characterize the POm thalamocortical innervation of adult mouse barrel cortex and describe its early postnatal development in both mice and rats. In adult mice, POm inputs form a dense plexus in layer Va that extends uniformly underneath layer IV barrels and septa. Innervation of layer IV is very sparse; a clear septal innervation pattern is evident only at the layer IV/Va border. This pattern differs subtly from that described previously in rats. Developmentally, in both species, POm axons are present in barrel cortex at birth, where in mice, they occupy layer IV as it differentiates. In contrast, in rats, POm axons do not enter layer IV until 1–2 days after its emergence from the cortical plate. In both species, arbors undergo progressive and directed growth. However, no layer IV septal innervation pattern emerges until several days after the cytoarchitectonic appearance of barrels and well after the emergence of whisker-related clusters of VPM thalamocortical axons. The mature pattern resolves earlier in rats than in mice. Taken together, these data reveal anatomical differences between mice and rats in development and organization of POm inputs to barrel cortex, with implications for species differences in the nature and plasticity of lemniscal and paralemniscal information processing. PMID:18496871

  2. Performance analysis for the CALIFA Barrel calorimeter of the R3B experiment

    NASA Astrophysics Data System (ADS)

    Alvarez-Pol, H.; Ashwood, N.; Aumann, T.; Bertini, D.; Cabanelas, P.; Casarejos, E.; Cederkall, J.; Cortina-Gil, D.; Díaz Fernández, P.; Duran, I.; Fiori, E.; Galaviz, D.; Labiche, M.; Nacher, E.; Pietras, B.; Savran, D.; Tengblad, O.; Teubig, P.

    2014-12-01

    The CALIFA calorimeter is an advanced detector for gamma rays and light charged particles, accordingly optimized for the demanding requirements of the physics programme proposed for the R3B facility at FAIR. The multipurpose character of CALIFA is required to fulfil challenging demands in energy resolution (5-6% at 1 MeV for gamma rays) and efficiency. Charged particles, e.g. protons of energies up to 320 MeV in the Barrel section, should also be identified with an energy resolution better to 1%. CALIFA is divided into two well-separated sections: a "Forward EndCap" and a cylindrical "Barrel" covering an angular range from 43.2° to 140.3°. The Barrel section, based on long CsI(Tl) pyramidal frustum crystals coupled to large area avalanche photodiodes (LAAPDs), attains the requested high efficiency for calorimetric purposes. The construction of the CALIFA Demonstrator, comprising 20% of the total detector, has already been initiated, and commissioning experiments are expected for 2014. The assessment of the capabilities and expected performance of the detector elements is a crucial step in their design, along with the prototypes evaluation. For this purpose, the Barrel geometry has been carefully implemented in the simulation package R3BRoot, including easily variable thicknesses of crystal wrapping and carbon fibre supports. A complete characterization of the calorimeter response (including efficiency, resolution, evaluation of energy and reconstruction losses) under different working conditions, with several physics cases selected to probe the detector performance over a wide range of applications, has been undertaken. Prototypes of different sections of the CALIFA Barrel have been modeled and their responses have been evaluated and compared with the experimental results. The present paper summarizes the outcome of the simulation campaign for the entire Barrel section and for the corresponding prototypes tested at different European installations.

  3. Observations of a solar storm from the stratosphere: The BARREL Mission

    NASA Astrophysics Data System (ADS)

    Halford, Alexa

    2016-07-01

    During the Balloon Array for Radiation belt Relativistic Electron Losses (BARREL) second campaign, BARREL observed with a single primary instrument, a 3"x3" NaI spectrometer measuring 20 keV - 10 MeV X-rays [Woodger et al 2015 JGR], portions of an entire solar storm. This very small event, in terms of geomagnetic activity, or one of the largest of the current solar cycle, in terms of solar energetic particle events, has given us a very clear set of observations of the response of the day side magnetosphere to the arrival of an interplanetary coronal mass ejection shock. The BARREL mission of opportunity working in tandem with the Van Allen Probes was designed to study the loss of radiation belt electrons to the ionosphere and upper atmosphere. However BARREL is able to see X-rays from a multitude of sources. During the second campaign, the Sun produced, and BARREL observed, an X-class flare [McGregor et al in prep.]. This was followed by BARREL observations of X-rays, gamma-rays, and directly injected protons from the solar energetic particle (SEP) event associated with the eruption from the Sun while simultaneously the Van Allen Probes observed the SEP protons in the inner magnetosphere [Halford et al 2016 submitted JGR]. Two days later the shock generated by the interplanetary coronal mass ejection (ICME-shock) hit the Earth while BARREL was in conjunction with the Van Allen Probes and GOES [Halford et al 2015 JGR]. Although this was a Mars directed CME and the Earth only received a glancing blow [Möstl et al 2015 Nat. Commun., Mays et al 2015 ApJ], the modest compression led to the formation of ultra low frequency (ULF) waves, electromagnetic ion cyclotron (EMIC) waves, and very low frequency (VLF) whistler mode waves [Halford and Mann 2016 submitted to JGR]. The combination of these waves and the enhancement of the local particle population led to precipitation of electrons remotely observed by BARREL. This was not a Halloween, Bastille Day, or one of the now

  4. Treatment of aneurysmal aberrant right subclavian artery with triple-barrel stent graft.

    PubMed

    Schwein, Adeline; Georg, Yannick; Ohana, Mickaël; Delay, Charline; Lejay, Anne; Thaveau, Fabien; Chakfe, Nabil

    2015-04-01

    Aneurysmal evolution of an aberrant right subclavian artery (ARSA) is an operative indication. Endovascular treatment is a minimally invasive procedure, which offers good short-term and midterm results. We describe a case of a 9-cm diameter ARSA aneurysm in a symptomatic man, treated with the triple-barrel technique using a thoracic aortic stent graft combined with surgical and endovascular revascularization of the supra-aortic trunks. Postoperatively, the patient developed a type III endoleak which was covered. The triple-barrel technique has been a proposed treatment approach for complex aortic arch pathologies and remains a less invasive option when compared with open surgery. PMID:25596407

  5. Improving atlas methodology

    USGS Publications Warehouse

    Robbins, C.S.; Dowell, B.A.; O'Brien, J.

    1987-01-01

    We are studying a sample of Maryland (2 %) and New Hampshire (4 %) Atlas blocks and a small sample in Maine. These three States used different sampling methods and block sizes. We compare sampling techniques, roadside with off-road coverage, our coverage with that of the volunteers, and different methods of quantifying Atlas results. The 7 1/2' (12-km) blocks used in the Maine Atlas are satisfactory for coarse mapping, but are too large to enable changes to be detected in the future. Most states are subdividing the standard 7 1/2' maps into six 5-km blocks. The random 1/6 sample of 5-km blocks used in New Hampshire, Vermont (published 1985), and many other states has the advantage of permitting detection of some changes in the future, but the disadvantage of leaving important habitats unsampled. The Maryland system of atlasing all 1,200 5-km blocks and covering one out of each six by quarterblocks (2 1/2-km) is far superior if enough observers can be found. A good compromise, not yet attempted, would be to Atlas a 1/6 random sample of 5-km blocks and also one other carefully selected (non-random) block on the same 7 1/2' map--the block that would include the best sample of habitats or elevations not in the random block. In our sample the second block raised the percentage of birds found from 86% of the birds recorded in the 7 1/2' quadrangle to 93%. It was helpful to list the expected species in each block and to revise this list annually. We estimate that 90-100 species could be found with intensive effort in most Maryland blocks; perhaps 95-105 in New Hampshire. It was also helpful to know which species were under-sampled so we could make a special effort to search for these. A total of 75 species per block (or 75% of the expected species in blocks with very restricted habitat diversity) is considered a practical and adequate goal in these States. When fewer than 60 species are found per block, a high proportion of the rarer species are missed, as well as some of

  6. Brain templates and atlases.

    PubMed

    Evans, Alan C; Janke, Andrew L; Collins, D Louis; Baillet, Sylvain

    2012-08-15

    The core concept within the field of brain mapping is the use of a standardized, or "stereotaxic", 3D coordinate frame for data analysis and reporting of findings from neuroimaging experiments. This simple construct allows brain researchers to combine data from many subjects such that group-averaged signals, be they structural or functional, can be detected above the background noise that would swamp subtle signals from any single subject. Where the signal is robust enough to be detected in individuals, it allows for the exploration of inter-individual variance in the location of that signal. From a larger perspective, it provides a powerful medium for comparison and/or combination of brain mapping findings from different imaging modalities and laboratories around the world. Finally, it provides a framework for the creation of large-scale neuroimaging databases or "atlases" that capture the population mean and variance in anatomical or physiological metrics as a function of age or disease. However, while the above benefits are not in question at first order, there are a number of conceptual and practical challenges that introduce second-order incompatibilities among experimental data. Stereotaxic mapping requires two basic components: (i) the specification of the 3D stereotaxic coordinate space, and (ii) a mapping function that transforms a 3D brain image from "native" space, i.e. the coordinate frame of the scanner at data acquisition, to that stereotaxic space. The first component is usually expressed by the choice of a representative 3D MR image that serves as target "template" or atlas. The native image is re-sampled from native to stereotaxic space under the mapping function that may have few or many degrees of freedom, depending upon the experimental design. The optimal choice of atlas template and mapping function depend upon considerations of age, gender, hemispheric asymmetry, anatomical correspondence, spatial normalization methodology and disease

  7. Level 1 Tornado PRA for the High Flux Beam Reactor

    SciTech Connect

    Bozoki, G.E.; Conrad, C.S.

    1994-05-01

    This report describes a risk analysis primarily directed at providing an estimate for the frequency of tornado induced damage to the core of the High Flux Beam Reactor (HFBR), and thus it constitutes a Level 1 Probabilistic Risk Assessment (PRA) covering tornado induced accident sequences. The basic methodology of the risk analysis was to develop a ``tornado specific`` plant logic model that integrates the internal random hardware failures with failures caused externally by the tornado strike and includes operator errors worsened by the tornado modified environment. The tornado hazard frequency, as well as earlier prepared structural and equipment fragility data, were used as input data to the model. To keep modeling/calculational complexity as simple as reasonable a ``bounding`` type, slightly conservative, approach was applied. By a thorough screening process a single dominant initiating event was selected as a representative initiator, defined as: ``Tornado Induced Loss of Offsite Power.`` The frequency of this initiator was determined to be 6.37E-5/year. The safety response of the HFBR facility resulted in a total Conditional Core Damage Probability of .621. Thus, the point estimate of the HFBR`s Tornado Induced Core Damage Frequency (CDF) was found to be: (CDF){sub Tornado} = 3.96E-5/year. This value represents only 7.8% of the internal CDF and thus is considered to be a small contribution to the overall facility risk expressed in terms of total Core Damage Frequency. In addition to providing the estimate of (CDF){sub Tornado}, the report documents, the relative importance of various tornado induced system, component, and operator failures that contribute most to (CDF){sub Tornado}.

  8. Advanced accident sequence precursor analysis level 1 models

    SciTech Connect

    Sattison, M.B.; Thatcher, T.A.; Knudsen, J.K.; Schroeder, J.A.; Siu, N.O.

    1996-03-01

    INEL has been involved in the development of plant-specific Accident Sequence Precursor (ASP) models for the past two years. These models were developed for use with the SAPHIRE suite of PRA computer codes. They contained event tree/linked fault tree Level 1 risk models for the following initiating events: general transient, loss-of-offsite-power, steam generator tube rupture, small loss-of-coolant-accident, and anticipated transient without scram. Early in 1995 the ASP models were revised based on review comments from the NRC and an independent peer review. These models were released as Revision 1. The Office of Nuclear Regulatory Research has sponsored several projects at the INEL this fiscal year to further enhance the capabilities of the ASP models. Revision 2 models incorporates more detailed plant information into the models concerning plant response to station blackout conditions, information on battery life, and other unique features gleaned from an Office of Nuclear Reactor Regulation quick review of the Individual Plant Examination submittals. These models are currently being delivered to the NRC as they are completed. A related project is a feasibility study and model development of low power/shutdown (LP/SD) and external event extensions to the ASP models. This project will establish criteria for selection of LP/SD and external initiator operational events for analysis within the ASP program. Prototype models for each pertinent initiating event (loss of shutdown cooling, loss of inventory control, fire, flood, seismic, etc.) will be developed. A third project concerns development of enhancements to SAPHIRE. In relation to the ASP program, a new SAPHIRE module, GEM, was developed as a specific user interface for performing ASP evaluations. This module greatly simplifies the analysis process for determining the conditional core damage probability for a given combination of initiating events and equipment failures or degradations.

  9. Validation of the ASTER instrument level 1A scene geometry

    USGS Publications Warehouse

    Kieffer, H.H.; Mullins, K.F.; MacKinnon, D.J.

    2008-01-01

    An independent assessment of the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) instrument geometry was undertaken by the U.S. ASTER Team, to confirm the geometric correction parameters developed and applied to Level 1A (radiometrically and geometrically raw with correction parameters appended) ASTER data. The goal was to evaluate the geometric quality of the ASTER system and the stability of the Terra spacecraft. ASTER is a 15-band system containing optical instruments with resolutions from 15- to 90-meters; all geometrically registered products are ultimately tied to the 15-meter Visible and Near Infrared (VNIR) sub-system. Our evaluation process first involved establishing a large database of Ground Control Points (GCP) in the mid-western United States; an area with features of an appropriate size for spacecraft instrument resolutions. We used standard U.S. Geological Survey (USGS) Digital Orthophoto Quads (DOQS) of areas in the mid-west to locate accurate GCPs by systematically identifying road intersections and recording their coordinates. Elevations for these points were derived from USGS Digital Elevation Models (DEMS). Road intersections in a swath of nine contiguous ASTER scenes were then matched to the GCPs, including terrain correction. We found no significant distortion in the images; after a simple image offset to absolute position, the RMS residual of about 200 points per scene was less than one-half a VNIR pixel. Absolute locations were within 80 meters, with a slow drift of about 10 meters over the entire 530-kilometer swath. Using strictly simultaneous observations of scenes 370 kilometers apart, we determined a stereo angle correction of 0.00134 degree with an accuracy of one microradian. The mid-west GCP field and the techniques used here should be widely applicable in assessing other spacecraft instruments having resolutions from 5 to 50-meters. ?? 2008 American Society for Photogrammetry and Remote Sensing.

  10. 27 CFR 25.160 - Tax adjustment for brewers who produce more than 2,000,000 barrels of beer.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... who produce more than 2,000,000 barrels of beer. 25.160 Section 25.160 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Tax on Beer Determination of Tax § 25.160 Tax adjustment for brewers who produce more than 2,000,000 barrels of beer....

  11. 27 CFR 25.160 - Tax adjustment for brewers who produce more than 2,000,000 barrels of beer.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... who produce more than 2,000,000 barrels of beer. 25.160 Section 25.160 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Tax on Beer Determination of Tax § 25.160 Tax adjustment for brewers who produce more than 2,000,000 barrels of beer....

  12. 27 CFR 25.160 - Tax adjustment for brewers who produce more than 2,000,000 barrels of beer.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... who produce more than 2,000,000 barrels of beer. 25.160 Section 25.160 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL BEER Tax on Beer Determination of Tax § 25.160 Tax adjustment for brewers who produce more than 2,000,000 barrels of beer....

  13. 27 CFR 25.160 - Tax adjustment for brewers who produce more than 2,000,000 barrels of beer.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... who produce more than 2,000,000 barrels of beer. 25.160 Section 25.160 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL BEER Tax on Beer Determination of Tax § 25.160 Tax adjustment for brewers who produce more than 2,000,000 barrels of beer....

  14. 27 CFR 25.160 - Tax adjustment for brewers who produce more than 2,000,000 barrels of beer.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... who produce more than 2,000,000 barrels of beer. 25.160 Section 25.160 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Tax on Beer Determination of Tax § 25.160 Tax adjustment for brewers who produce more than 2,000,000 barrels of beer....

  15. ATLAS-1 Logo

    NASA Technical Reports Server (NTRS)

    1990-01-01

    The primary payload for the Space Shuttle mission STS-45, launched March 24, 1992, was the Atmospheric Laboratory for Applications and Science-1 (ATLAS-1)which was mounted on nondeployable Spacelab pallets in the orbiter cargo bay. Eight countries, th U.S., France, Germany, Belgium, United Kingdom, Switzerland, The Netherlands, and Japan, provided 12 instruments designed to perform 14 investigations in four fields. Atmospheric science instruments/investigations: Atmospheric Lyman-Alpha Emissions (ALAE); Atmospheric Trace Molecule Spectroscopy (ATMOS); Grille Spectrometer (GRILLE); Imaging Spectrometric Observatory (ISO); Millimeter-Wave Atmospheric Sounder (MAS). Solar Science: Active Cavity Radiometer Irradiance Monitor (ACRIM); Measurement of the Solar Constant (SOLCON); Solar Spectrum from 180 to 3,200 Nanometers (SOLSPEC); Solar Ultraviolet Spectral Irradiance Monitor (SUSIM). Space Plasma Physics: Atmospheric Emissions Photometric Imaging (AEPI); Space Experiments with Particle Accelerators (SEPAC). Ultraviolet astronomy: Far Ultraviolet Space Telescope (FAUST). This is the logo or emblem that was designed to represent the ATLAS-1 payload.

  16. Atlas 2 Animation

    NASA Technical Reports Server (NTRS)

    1993-01-01

    The Atmospheric Laboratory for Applications and Science-2 (ATLAS-2), was designed to collect data on the relationship between the sun's energy output and Earth's middle atmosphere and how these factors affect the ozone layer. The ATLAS-2 flew on the Space Shuttle Discovery's mission SST-56, launched on April 8, 1993. The videotape consists of an animated tour of the instruments that were included as part of the mission. The first half of the tape shows the various instruments, pointing to each in turn and identifying each by the associated initialisms. The instruments identified were: the Atmospheric Trace Molecule Spectroscopy (ATMOS), Millimeter Wave Atmospheric Sounder (MAS), Shuttle Solar Backscatter Ultraviolet/A (SSBUV/A) spectrometer, Solar Spectrum Measurement (SOLSPEC) instrument, Solar Ultraviolet Irradiance Monitor (SUSIM), Active Cavity Radiometer (ACR) and Solar Constant (SOLCON).) The second half of the animation shows the same tour without the pointing or the identification of the instruments.

  17. The ATLAS Forward Calorimeter

    NASA Astrophysics Data System (ADS)

    Artamonov, A.; Bailey, D.; Belanger, G.; Cadabeschi, M.; Chen, T.-Y.; Epshteyn, V.; Gorbounov, P.; Joo, K. K.; Khakzad, M.; Khovanskiy, V.; Krieger, P.; Loch, P.; Mayer, J.; Neuheimer, E.; Oakham, F. G.; O'Neill, M.; Orr, R. S.; Qi, M.; Rutherfoord, J.; Savine, A.; Schram, M.; Shatalov, P.; Shaver, L.; Shupe, M.; Stairs, G.; Strickland, V.; Tompkins, D.; Tsukerman, I.; Vincent, K.

    2008-02-01

    Forward calorimeters, located near the incident beams, complete the nearly 4π coverage for high pT particles resulting from proton-proton collisions in the ATLAS detector at the Large Hadron Collider at CERN. Both the technology and the deployment of the forward calorimeters in ATLAS are novel. The liquid argon rod/tube electrode structure for the forward calorimeters was invented specifically for applications in high rate environments. The placement of the forward calorimeters adjacent to the other calorimeters relatively close to the interaction point provides several advantages including nearly seamless calorimetry and natural shielding for the muon system. The forward calorimeter performance requirements are driven by events with missing ET and tagging jets.

  18. Mercury-Atlas Test Launch

    NASA Technical Reports Server (NTRS)

    1961-01-01

    A NASA Project Mercury spacecraft was test launched at 11:15 AM EST on April 25, 1961 from Cape Canaveral, Florida, in a test designed to qualify the Mercury Spacecraft and all systems, which must function during orbit and reentry from orbit. The Mercury-Atlas vehicle was destroyed by Range Safety Officer about 40 seconds after liftoff. The spacecraft was recovered and appeared to be in good condition. Atlas was designed to launch payloads into low Earth orbit, geosynchronous transfer orbit or geosynchronous orbit. NASA first launched Atlas as a space launch vehicle in 1958. Project SCORE, the first communications satellite that transmitted President Eisenhower's pre-recorded Christmas speech around the world, was launched on an Atlas. For all three robotic lunar exploration programs, Atlas was used. Atlas/ Centaur vehicles launched both Mariner and Pioneer planetary probes. The current operational Atlas II family has a 100% mission success rating. For more information about Atlas, please see Chapter 2 in Roger Launius and Dennis Jenkins' book To Reach the High Frontier published by The University Press of Kentucky in 2002.

  19. Assessment Atlas, 1982-83.

    ERIC Educational Resources Information Center

    Yosemite Community Coll. District, Modesto, CA.

    Designed to provide information of value in establishing a base for decisionmaking in the Yosemite Community College District (YCCD), this assessment atlas graphically presents statistical data on the District as a whole, its two campuses, and YCCD Central Services for 1982-83. After an introduction to the use of the assessment atlas and…

  20. Assessment Atlas, 1983-84.

    ERIC Educational Resources Information Center

    Yosemite Community Coll. District, Modesto, CA.

    Designed to provide information of value in establishing a base for decision making in the Yosemite Community College District (YCCD), this assessment atlas graphically presents statistical data for the District as a whole, its two campuses, and YCCD Central Services for 1983-84. After an introduction to the use of the assessment atlas and…

  1. ATLAS discoveries of optical transients

    NASA Astrophysics Data System (ADS)

    Tonry, J.; Denneau, L.; Stalder, B.; Heinze, A.; Sherstyuk, A.; Rest, A.; Smith, K. W.; Smartt, S. J.

    2016-03-01

    We report the following transients found by the ATLAS survey (Tonry et al. ATel #8680). ATLAS is a twin 0.5m telescope system on Haleakala and Mauna Loa. The first unit is robotically operational on Haleakala (see http://www.fallingstar.com).

  2. Computed tomography manifestation of a triple-barreled aortic dissection: the Mercedes-Benz mark sign.

    PubMed

    Shin, M S; Zorn, G L; Ho, K J

    1988-04-01

    Computed tomographic (CT) findings of a rare case of triple-barreled aortic dissection was described. CT demonstrated the extent of dissection, a communication between two channels, and three lumens separated by the intimal flap and a thin undetached tunica media, resembling a Mercedes-Benz mark. PMID:3168525

  3. PHYSICAL VAPOR DEPOSITION OF TANTALUM ON GUN BARREL STEEL (SYSTEMS ANLAYSIS BRANCH, SUSTAINABLE TECHNOLOGY DIVISION, NRMRL)

    EPA Science Inventory

    This project entails the development of an alternative technology for plating gun barrel steel to replace the process electroplating of chrome (Cr-electroplate) with physical vapor deposition of tantalum (Ta-PVD). Developed by Benet Laboratory at Watervliet Arsenal, this project'...

  4. High speed machining of space shuttle external tank liquid hydrogen barrel panel

    NASA Technical Reports Server (NTRS)

    Hankins, J. D.

    1983-01-01

    Actual and projected optimum High Speed Machining data for producing shuttle external tank liquid hydrogen barrel panels of aluminum alloy 2219-T87 are reported. The data included various machining parameters; e.g., spindle speeds, cutting speed, table feed, chip load, metal removal rate, horsepower, cutting efficiency, cutter wear (lack of) and chip removal methods.

  5. 27 CFR 478.113a - Importation of firearm barrels by nonlicensees.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2013-04-01 2013-04-01 false Importation of firearm barrels by nonlicensees. 478.113a Section 478.113a Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION COMMERCE...

  6. 27 CFR 478.113a - Importation of firearm barrels by nonlicensees.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2014-04-01 2014-04-01 false Importation of firearm barrels by nonlicensees. 478.113a Section 478.113a Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION COMMERCE...

  7. 27 CFR 478.113a - Importation of firearm barrels by nonlicensees.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2012-04-01 2010-04-01 true Importation of firearm barrels by nonlicensees. 478.113a Section 478.113a Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION COMMERCE...

  8. 27 CFR 478.113a - Importation of firearm barrels by nonlicensees.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Importation of firearm barrels by nonlicensees. 478.113a Section 478.113a Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION COMMERCE...

  9. 27 CFR 478.113a - Importation of firearm barrels by nonlicensees.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2011-04-01 2010-04-01 true Importation of firearm barrels by nonlicensees. 478.113a Section 478.113a Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION COMMERCE...

  10. Analysis of Fibular Single Graft and Fibular Double-barrel Graft for Mandibular Reconstruction

    PubMed Central

    Shimizu, Yusuke; Ihara, Jyun; Kishi, Kazuo

    2016-01-01

    Background: High-quality mandibular reconstruction using vascularized free fibular graft is necessary to provide an osseointegrated dental implant and fixed denture. An appropriate crown–implant ratio is needed, and a good match between bones is extremely important. There are no articles describing the analysis and evaluation of both the fibula and mandible in the same patients. Methods: Computed tomography images of both mandible and fibula of 80 patients were selected in a random manner. We measured bone height of the fibula and mandible at specified points and evaluated the difference of bone height between the fibula and mandible using fibular single or double-barrel grafts. Results: The percentage of patients who had a “good” result for a fibular single graft was only 13.8%. There was no significant difference in bone heights when analyzed by gender. Whether patients were dentulous or not had a large influence on the difference between fibular and mandibular bone heights. Most young patients, but only half of older patients, needed fibular double-barrel grafts. Overweight patients with a high body mass index more often needed fibular double-barrel grafts. Conclusions: For mandibular reconstruction using a fibular graft, preoperative analysis of the patient’s profile and proper use of a fibular single or double-barrel graft contribute to minimizing the difference between the height of the grafted fibula and native mandible and are keys to an ideal reconstruction with good cosmetics and function.

  11. Twenty years of barrel-stave flextensional transducer technology in Canada

    NASA Astrophysics Data System (ADS)

    Jones, Dennis F.

    2005-04-01

    The barrel-stave flextensional transducer, a compact underwater sound source, was conceived at DRDC Atlantic in 1986 [G. W. McMahon and D. F. Jones, U.S. Patent No. 4,922,470 (1 May 1990); Canadian Patent No. 1,285,646 (2 July 1991)]. Over the years, five barrel-stave designs belonging to three flextensional classes were built and tested at DRDC Atlantic. Three Class I transducers with operating frequencies ranging from 800 to 1600 Hz were integrated into submarine communications buoys, low frequency active horizontal projector arrays, and a broadband sonar towbody. A high-power Class II and broadband (1-7 kHz) Class III transducer were deployed under the ice in the Lincoln Sea for research related to rapidly deployable surveillance systems. These barrel-stave flextensional transducers have also supported a variety of marine mammal studies including vocal mimicry in long-finned pilot whales, coda dialects in sperm whales, and the R&D of acoustic detection and tracking systems for endangered northern right whales. In August 2004 a barrel-stave transducer was used to lure a trapped juvenile humpback whale to the sluice gates of a tidal generating station on the Annapolis River in Nova Scotia by transmitting humpback whale calls underwater. The acoustic performance parameters for all 5 transducers will be presented.

  12. 33 CFR 135.103 - Levy and payment of barrel fee on OCS oil.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... regulations of the IRS at 26 CFR part 301, § 301.9001. Federal government entitlement to royalty oil does not... SECURITY (CONTINUED) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OFFSHORE OIL POLLUTION... of the Minerals Management Service contained in 30 CFR 250.180. (c) The barrel fee levied...

  13. Effect of Associative Learning on Memory Spine Formation in Mouse Barrel Cortex

    PubMed Central

    Jasinska, Malgorzata; Siucinska, Ewa; Jasek, Ewa; Litwin, Jan A.; Pyza, Elzbieta; Kossut, Malgorzata

    2016-01-01

    Associative fear learning, in which stimulation of whiskers is paired with mild electric shock to the tail, modifies the barrel cortex, the functional representation of sensory receptors involved in the conditioning, by inducing formation of new inhibitory synapses on single-synapse spines of the cognate barrel hollows and thus producing double-synapse spines. In the barrel cortex of conditioned, pseudoconditioned, and untreated mice, we analyzed the number and morphological features of dendritic spines at various maturation and stability levels: sER-free spines, spines containing smooth endoplasmic reticulum (sER), and spines containing spine apparatus. Using stereological analysis of serial sections examined by transmission electron microscopy, we found that the density of double-synapse spines containing spine apparatus was significantly increased in the conditioned mice. Learning also induced enhancement of the postsynaptic density area of inhibitory synapses as well as increase in the number of polyribosomes in such spines. In single-synapse spines, the effects of conditioning were less pronounced and included increase in the number of polyribosomes in sER-free spines. The results suggest that fear learning differentially affects single- and double-synapse spines in the barrel cortex: it promotes maturation and stabilization of double-synapse spines, which might possibly contribute to permanent memory formation, and upregulates protein synthesis in single-synapse spines. PMID:26819780

  14. EVALUATION OF EMISSIONS FROM THE OPEN BURNING OF HOUSEHOLD WASTE IN BARRELS - VOLUME 1. TECHNICAL REPORT

    EPA Science Inventory

    The report gives results of a detailed emissions characterization study undertaken to examine, characterize, and quantify emissions from the simulated burning of household waste in barrels. The study evaluated two waste streams: that of an avid recycler, who removed most of the r...

  15. EVALUATION OF EMISSIONS FROM THE OPEN BURNING OF HOUSEHOLD WASTES IN BARRELS - VOLUME 2. APPENDICES

    EPA Science Inventory

    The report gives results of a detailed emissions characterization study undertaken to examine, characterize, and quantify emissions from the simulated burning of household waste in barrels. The study evaluated two waste streams: that of an avid recycler, who removed most of the r...

  16. Effects of Dimethyl Sulfoxide on Neuronal Response Characteristics in Deep Layers of Rat Barrel Cortex

    PubMed Central

    Soltani, Narjes; Mohammadi, Elham; Allahtavakoli, Mohammad; Shamsizadeh, Ali; Roohbakhsh, Ali; Haghparast, Abbas

    2016-01-01

    Introduction: Dimethyl sulfoxide (DMSO) is a chemical often used as a solvent for water-insoluble drugs. In this study, we evaluated the effect of intracerebroventricular (ICV) administration of DMSO on neural response characteristics (in 1200–1500 μm depth) of the rat barrel cortex. Methods: DMSO solution was prepared in 10% v/v concentration and injected into the lateral ventricle of rats. Neuronal spontaneous activity and neuronal responses to deflection of the principal whisker (PW) and adjacent whisker (AW) were recorded in barrel cortex. A condition test ratio (CTR) was used to measure inhibitory receptive fields in barrel cortex. Results: The results showed that both PW and AW evoked ON and OFF responses, neuronal spontaneous activity and inhibitory receptive fields did not change following ICV administration of DMSO. Conclusion: Results of this study suggest that acute ICV administration of 10% DMSO did not modulate the electrophysiological characteristics of neurons in the l deep ayers of rat barrel cortex. PMID:27563414

  17. 7 CFR 58.425 - Conveyor for moving and draining block or barrel cheese.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 3 2014-01-01 2014-01-01 false Conveyor for moving and draining block or barrel cheese. 58.425 Section 58.425 Agriculture Regulations of the Department of Agriculture (Continued... cheese. The conveyor shall be constructed so that it will not contaminate the cheese and be...

  18. 7 CFR 58.425 - Conveyor for moving and draining block or barrel cheese.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Conveyor for moving and draining block or barrel cheese. 58.425 Section 58.425 Agriculture Regulations of the Department of Agriculture (Continued... cheese. The conveyor shall be constructed so that it will not contaminate the cheese and be...

  19. 7 CFR 58.425 - Conveyor for moving and draining block or barrel cheese.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 3 2013-01-01 2013-01-01 false Conveyor for moving and draining block or barrel cheese. 58.425 Section 58.425 Agriculture Regulations of the Department of Agriculture (Continued... cheese. The conveyor shall be constructed so that it will not contaminate the cheese and be...

  20. 7 CFR 58.425 - Conveyor for moving and draining block or barrel cheese.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 3 2012-01-01 2012-01-01 false Conveyor for moving and draining block or barrel cheese. 58.425 Section 58.425 Agriculture Regulations of the Department of Agriculture (Continued... cheese. The conveyor shall be constructed so that it will not contaminate the cheese and be...

  1. Characterization of the targeting signal in mitochondrial β-barrel proteins.

    PubMed

    Jores, Tobias; Klinger, Anna; Groß, Lucia E; Kawano, Shin; Flinner, Nadine; Duchardt-Ferner, Elke; Wöhnert, Jens; Kalbacher, Hubert; Endo, Toshiya; Schleiff, Enrico; Rapaport, Doron

    2016-01-01

    Mitochondrial β-barrel proteins are synthesized on cytosolic ribosomes and must be specifically targeted to the organelle before their integration into the mitochondrial outer membrane. The signal that assures such precise targeting and its recognition by the organelle remained obscure. In the present study we show that a specialized β-hairpin motif is this long searched for signal. We demonstrate that a synthetic β-hairpin peptide competes with the import of mitochondrial β-barrel proteins and that proteins harbouring a β-hairpin peptide fused to passenger domains are targeted to mitochondria. Furthermore, a β-hairpin motif from mitochondrial proteins targets chloroplast β-barrel proteins to mitochondria. The mitochondrial targeting depends on the hydrophobicity of the β-hairpin motif. Finally, this motif interacts with the mitochondrial import receptor Tom20. Collectively, we reveal that β-barrel proteins are targeted to mitochondria by a dedicated β-hairpin element, and this motif is recognized at the organelle surface by the outer membrane translocase. PMID:27345737

  2. High speed machining of space shuttle external tank liquid hydrogen barrel panel

    NASA Astrophysics Data System (ADS)

    Hankins, J. D.

    1983-11-01

    Actual and projected optimum High Speed Machining data for producing shuttle external tank liquid hydrogen barrel panels of aluminum alloy 2219-T87 are reported. The data included various machining parameters; e.g., spindle speeds, cutting speed, table feed, chip load, metal removal rate, horsepower, cutting efficiency, cutter wear (lack of) and chip removal methods.

  3. A summary of the BARREL campaigns: Technique for studying electron precipitation

    NASA Astrophysics Data System (ADS)

    Woodger, L. A.; Halford, A. J.; Millan, R. M.; McCarthy, M. P.; Smith, D. M.; Bowers, G. S.; Sample, J. G.; Anderson, B. R.; Liang, X.

    2015-06-01

    The Balloon Array for Radiation belt Relativistic Electron Losses (BARREL) studies the loss of energetic electrons from Earth's radiation belts. BARREL's array of slowly drifting balloon payloads was designed to capitalize on magnetic conjunctions with NASA's Van Allen Probes. Two campaigns were conducted from Antarctica in 2013 and 2014. During the first campaign in January and February of 2013, there were three moderate geomagnetic storms with SYM-Hmin < -40 nT. Similarly, two minor geomagnetic storms occurred during the second campaign, starting in December of 2013 and continuing on into February of 2014. Throughout the two campaigns, BARREL observed electron precipitation over a wide range of energies and exhibiting temporal structure from hundreds of milliseconds to hours. Relativistic electron precipitation was observed in the dusk to midnight sector, and microburst precipitation was primarily observed near dawn. In this paper we review the two BARREL science campaigns and discuss the data products and analysis techniques as applied to relativistic electron precipitation observed on 19 January 2013.

  4. Assessment of Residential Rain Barrel Water Quality and Use in Cincinnati, Ohio

    EPA Science Inventory

    The collection, storage, and reuse of rainwater collected in rain barrels from urban rooftop areas assists municipalities in achieving stormwater management objectives and in some areas also serves as an adjunct resource for domestic water supplies. In this study, rainwater reuse...

  5. A βα-barrel built by the combination of fragments from different folds

    PubMed Central

    Bharat, Tanmay A. M.; Eisenbeis, Simone; Zeth, Kornelius; Höcker, Birte

    2008-01-01

    Combinatorial assembly of protein domains plays an important role in the evolution of proteins. There is also evidence that protein domains have come together from stable subdomains. This concept of modular assembly could be used to construct new well folded proteins from stable protein fragments. Here, we report the construction of a chimeric protein from parts of a (βα)8-barrel enzyme from histidine biosynthesis pathway (HisF) and a protein of the (βα)5-flavodoxin-like fold (CheY) from Thermotoga maritima that share a high structural similarity. We expected this construct to fold into a full (βα)8-barrel. Our results show that the chimeric protein is a stable monomer that unfolds with high cooperativity. Its three-dimensional structure, which was solved to 3.1 Å resolution by x-ray crystallography, confirms a barrel-like fold in which the overall structures of the parent proteins are highly conserved. The structure further reveals a ninth strand in the barrel, which is formed by residues from the HisF C terminus and an attached tag. This strand invades between β-strand 1 and 2 of the CheY part closing a gap in the structure that might be due to a suboptimal fit between the fragments. Thus, by a combination of parts from two different folds and a small arbitrary fragment, we created a well folded and stable protein. PMID:18632584

  6. A beta alpha-barrel built by the combination of fragments from different folds.

    PubMed

    Bharat, Tanmay A M; Eisenbeis, Simone; Zeth, Kornelius; Höcker, Birte

    2008-07-22

    Combinatorial assembly of protein domains plays an important role in the evolution of proteins. There is also evidence that protein domains have come together from stable subdomains. This concept of modular assembly could be used to construct new well folded proteins from stable protein fragments. Here, we report the construction of a chimeric protein from parts of a (betaalpha)(8)-barrel enzyme from histidine biosynthesis pathway (HisF) and a protein of the (betaalpha)(5)-flavodoxin-like fold (CheY) from Thermotoga maritima that share a high structural similarity. We expected this construct to fold into a full (betaalpha)(8)-barrel. Our results show that the chimeric protein is a stable monomer that unfolds with high cooperativity. Its three-dimensional structure, which was solved to 3.1 A resolution by x-ray crystallography, confirms a barrel-like fold in which the overall structures of the parent proteins are highly conserved. The structure further reveals a ninth strand in the barrel, which is formed by residues from the HisF C terminus and an attached tag. This strand invades between beta-strand 1 and 2 of the CheY part closing a gap in the structure that might be due to a suboptimal fit between the fragments. Thus, by a combination of parts from two different folds and a small arbitrary fragment, we created a well folded and stable protein. PMID:18632584

  7. 3. PHOTOCOPY OF 1/2 OF CA. 1880 STREOCARD SHOWING 'BARREL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. PHOTOCOPY OF 1/2 OF CA. 1880 STREOCARD SHOWING 'BARREL SHOT' VIEW LOOKING DOWN THE LENGTH OF LOWER DECK. JAMES CREMER, PHOTOGRAPHER AND PUBLISHER, 18 SOUTH EIGHTH STREET, PHILADELPHIA. - Callowhill Street Bridge, Schuylkill River at Spring Garden & Callowhill Streets, Philadelphia, Philadelphia County, PA

  8. 7 CFR 58.425 - Conveyor for moving and draining block or barrel cheese.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Conveyor for moving and draining block or barrel cheese. 58.425 Section 58.425 Agriculture Regulations of the Department of Agriculture (Continued... and Grading Service 1 Equipment and Utensils § 58.425 Conveyor for moving and draining block or...

  9. From Constructs to Crystals - Towards Structure Determination of β-barrel Outer Membrane Proteins.

    PubMed

    Noinaj, Nicholas; Mayclin, Stephen; Stanley, Ann M; Jao, Christine C; Buchanan, Susan K

    2016-01-01

    Membrane proteins serve important functions in cells such as nutrient transport, motility, signaling, survival and virulence, yet constitute only ~1% percent of known structures. There are two types of membrane proteins, α-helical and β-barrel. While α-helical membrane proteins can be found in nearly all cellular membranes, β-barrel membrane proteins can only be found in the outer membranes of mitochondria, chloroplasts, and Gram-negative bacteria. One common bottleneck in structural studies of membrane proteins in general is getting enough pure sample for analysis. In hopes of assisting those interested in solving the structure of their favorite β-barrel outer membrane protein (OMP), general protocols are presented for the production of target β-barrel OMPs at levels useful for structure determination by either X-ray crystallography and/or NMR spectroscopy. Here, we outline construct design for both native expression and for expression into inclusion bodies, purification using an affinity tag, and crystallization using detergent screening, bicelle, and lipidic cubic phase techniques. These protocols have been tested and found to work for most OMPs from Gram-negative bacteria; however, there are some targets, particularly for mitochondria and chloroplasts that may require other methods for expression and purification. As such, the methods here should be applicable for most projects that involve OMPs from Gram-negative bacteria, yet the expression levels and amount of purified sample will vary depending on the target OMP. PMID:27404000

  10. Effect of Associative Learning on Memory Spine Formation in Mouse Barrel Cortex.

    PubMed

    Jasinska, Malgorzata; Siucinska, Ewa; Jasek, Ewa; Litwin, Jan A; Pyza, Elzbieta; Kossut, Malgorzata

    2016-01-01

    Associative fear learning, in which stimulation of whiskers is paired with mild electric shock to the tail, modifies the barrel cortex, the functional representation of sensory receptors involved in the conditioning, by inducing formation of new inhibitory synapses on single-synapse spines of the cognate barrel hollows and thus producing double-synapse spines. In the barrel cortex of conditioned, pseudoconditioned, and untreated mice, we analyzed the number and morphological features of dendritic spines at various maturation and stability levels: sER-free spines, spines containing smooth endoplasmic reticulum (sER), and spines containing spine apparatus. Using stereological analysis of serial sections examined by transmission electron microscopy, we found that the density of double-synapse spines containing spine apparatus was significantly increased in the conditioned mice. Learning also induced enhancement of the postsynaptic density area of inhibitory synapses as well as increase in the number of polyribosomes in such spines. In single-synapse spines, the effects of conditioning were less pronounced and included increase in the number of polyribosomes in sER-free spines. The results suggest that fear learning differentially affects single- and double-synapse spines in the barrel cortex: it promotes maturation and stabilization of double-synapse spines, which might possibly contribute to permanent memory formation, and upregulates protein synthesis in single-synapse spines. PMID:26819780

  11. Metal dust deposition in a shotgun wound associated with barrel modification.

    PubMed

    Williams, Andrew S; Bowes, Matthew J

    2016-03-01

    Contact-range gunshot wounds commonly demonstrate deposition of black soot in and around the wound. Deposition of other visible pigments originating from the firearm has not been specifically described. In the current case, an adult male was found dead adjacent to a shotgun fixed in a vice grip with a modified, shortened barrel. A handheld, powered, metal grinding wheel was nearby. Autopsy revealed an intraoral gunshot wound, including soot deposition in and around the mouth and within the wound track. In addition, there was a peculiar, gray, lustrous film on the lips, gingiva, and anterior teeth. The material was concentrated around the most severe areas of injury in the anterior mouth and easily rubbed off with a cotton swab. It was not visualized in the rest of the mouth and not present in the larynx, or the esophagus. Overall, our opinion is that this unique, gray, lustrous film represents deposition of fine metallic dust that accumulated in the barrel of the shotgun during its modification with the grinding wheel. This type of unique pigment deposition should be recognized by forensic pathologists as possibly being related to the discharge of a firearm with a recently modified barrel or other cause for fine metallic dust accumulation within the barrel. Depending on the circumstances of the case, collection of samples of such metal dust deposits could be indicated for subsequent analysis. PMID:26782960

  12. Barrel inspection utilizing a 14 MeV neutron beam and associate alpha particle method.

    PubMed

    Sudac, Davorin; Matika, Dario; Nađ, Karlo; Obhođaš, Jasmina; Valkovic, Vladivoj

    2012-07-01

    A multi-sensor system was evaluated for the determination of barrel content with regard to eventual pollution hazards. The proposed system is able to investigate (in situ) the interior of a barrel filled with various unknown substances ranging from chemical and radioactive waste, raw sewage sludge, municipal incinerator ashes to common household trash. The crucial part of the system is a neutron sensor, which enables the identification of substance content without actually opening the barrel at all. A comparative laboratory test with the 3″×3″ and 5″×5″×10″ NaI(Tl) gamma ray detectors was made after which 3″×3″ detector was selected and incorporated in the submarine called "Surveyor". A field test was made in the Croatian Adriatic coast on the island Lošinj. Field tests show that the commercial system utilizing the described method could be constructed for barrel inspection regardless of the measurement environment (underwater, on land, dumping site, isolated location, etc.). PMID:22221463

  13. Superior long-term stability of a glucose biosensor based on inserted barrel plating gold electrodes.

    PubMed

    Hsu, Cheng-Teng; Hsiao, Hung-Chan; Fang, Mei-Yen; Zen, Jyh-Myng

    2009-10-15

    Disposable one shot usage blood glucose strips are routinely used in the diagnosis and management of diabetes mellitus and their performance can vary greatly. In this paper we critically evaluated the long-term stability of glucose strips made of barrel plating gold electrodes. Compared to other glucose biosensing platforms of vapor deposited palladium and screen printed carbon electrodes, the proposed glucose biosensor was found to show the best stability among the three biosensing platforms in thermal acceleration experiments at 40 degrees C for 6 months with an average bias of 3.4% at glucose concentrations of 5-20 mM. The precision test of this barrel plating gold glucose biosensor also showed the best performance (coefficients of variation in the range of 1.4-2.4%) in thermal acceleration experiments at 40 degrees C, 50 degrees C and 70 degrees C for 27 days. Error grid analysis revealed that all measurements fell in zone A and zone B. Regression analysis showed no significant difference between the proposed biosensor and the reference method at 99% confidence level. The amperometric glucose biosensor fabricated by inserting two barrel plating gold electrodes onto an injection-molding plastic base followed by immobilizing with a bio-reagent layer and membrane was very impressive with a long-term stability up to 2.5 years at 25 degrees C. Overall, these results indicated that the glucose oxidase/barrel plating gold biosensing platform is ideal for long-term accurate glycemic control. PMID:19729292

  14. Learning-Dependent Plasticity of the Barrel Cortex Is Impaired by Restricting GABA-Ergic Transmission

    PubMed Central

    Posluszny, Anna; Liguz-Lecznar, Monika; Turzynska, Danuta; Zakrzewska, Renata; Bielecki, Maksymilian; Kossut, Malgorzata

    2015-01-01

    Experience-induced plastic changes in the cerebral cortex are accompanied by alterations in excitatory and inhibitory transmission. Increased excitatory drive, necessary for plasticity, precedes the occurrence of plastic change, while decreased inhibitory signaling often facilitates plasticity. However, an increase of inhibitory interactions was noted in some instances of experience-dependent changes. We previously reported an increase in the number of inhibitory markers in the barrel cortex of mice after fear conditioning engaging vibrissae, observed concurrently with enlargement of the cortical representational area of the row of vibrissae receiving conditioned stimulus (CS). We also observed that an increase of GABA level accompanied the conditioning. Here, to find whether unaltered GABAergic signaling is necessary for learning-dependent rewiring in the murine barrel cortex, we locally decreased GABA production in the barrel cortex or reduced transmission through GABAA receptors (GABAARs) at the time of the conditioning. Injections of 3-mercaptopropionic acid (3-MPA), an inhibitor of glutamic acid decarboxylase (GAD), into the barrel cortex prevented learning-induced enlargement of the conditioned vibrissae representation. A similar effect was observed after injection of gabazine, an antagonist of GABAARs. At the behavioral level, consistent conditioned response (cessation of head movements in response to CS) was impaired. These results show that appropriate functioning of the GABAergic system is required for both manifestation of functional cortical representation plasticity and for the development of a conditioned response. PMID:26641862

  15. Characterization of the targeting signal in mitochondrial β-barrel proteins

    PubMed Central

    Jores, Tobias; Klinger, Anna; Groß, Lucia E.; Kawano, Shin; Flinner, Nadine; Duchardt-Ferner, Elke; Wöhnert, Jens; Kalbacher, Hubert; Endo, Toshiya; Schleiff, Enrico; Rapaport, Doron

    2016-01-01

    Mitochondrial β-barrel proteins are synthesized on cytosolic ribosomes and must be specifically targeted to the organelle before their integration into the mitochondrial outer membrane. The signal that assures such precise targeting and its recognition by the organelle remained obscure. In the present study we show that a specialized β-hairpin motif is this long searched for signal. We demonstrate that a synthetic β-hairpin peptide competes with the import of mitochondrial β-barrel proteins and that proteins harbouring a β-hairpin peptide fused to passenger domains are targeted to mitochondria. Furthermore, a β-hairpin motif from mitochondrial proteins targets chloroplast β-barrel proteins to mitochondria. The mitochondrial targeting depends on the hydrophobicity of the β-hairpin motif. Finally, this motif interacts with the mitochondrial import receptor Tom20. Collectively, we reveal that β-barrel proteins are targeted to mitochondria by a dedicated β-hairpin element, and this motif is recognized at the organelle surface by the outer membrane translocase. PMID:27345737

  16. VARIABLES AFFECTING EMISSIONS OF PCDDS/FS FROM UNCONTROLLED COMBUSTION OF HOUSEHOLD WASTE IN BARRELS

    EPA Science Inventory

    The uncontrolled burning of household waste in barrels has recently been implicated as a major source of airborne emissions of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDDs/Fs). Based on the need to generate a more accurate emission factor for burn ba...

  17. Npas4 Expression in Two Experimental Models of the Barrel Cortex Plasticity

    PubMed Central

    Kaliszewska, Aleksandra; Kossut, Malgorzata

    2015-01-01

    Npas4 has recently been identified as an important factor in brain plasticity, particularly in mechanisms of inhibitory control. Little is known about Npas4 expression in terms of cortical plasticity. In the present study expressions of Npas4 and the archetypal immediate early gene (IEG) c-Fos were investigated in the barrel cortex of mice after sensory deprivation (sparing one row of whiskers for 7 days) or sensory conditioning (pairing stimulation of one row of whiskers with aversive stimulus). Laser microdissection of individual barrel rows allowed for analysis of IEGs expression precisely in deprived and nondeprived barrels (in deprivation study) or stimulated and nonstimulated barrels (in conditioning study). Cortex activation by sensory conditioning was found to upregulate the expression of both Npas4 and c-Fos. Reorganization of cortical circuits triggered by removal of selected rows of whiskers strongly affected c-Fos but not Npas4 expression. We hypothesize that increased inhibitory synaptogenesis observed previously after conditioning may be mediated by Npas4 expression. PMID:25785202

  18. 77 FR 37321 - Safety Zone, Barrel Recovery, Lake Superior; Duluth, MN

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-21

    ... FR Federal Register NPRM Notice of Proposed Rulemaking A. Regulatory History and Information The... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone, Barrel Recovery, Lake Superior; Duluth, MN... in the 1960's in a portion of Lake Superior approximately between Stoney Point and Brighton...

  19. WESTCARB Carbon Atlas

    DOE Data Explorer

    The West Coast Regional Carbon Sequestration Partnership (known as WESTCARB) was established in Fall 2003. It is one of seven research partnerships co-funded by DOE to characterize regional carbon sequestration opportunities and conduct pilot-scale validation tests. The California Energy Commission manages WESTCARB and is a major co-funder. WESTCARB is characterizing the extent and capacity of geologic formations capable of storing CO2, known as sinks. Results are entered into a geographic information system (GIS) database, along with the location of major CO2-emitting point sources in each of the six WESTCARB states, enabling researchers and the public to gauge the proximity of candidate CO2 storage sites to emission sources and the feasibility of linking them via pipelines. Specifically, the WESTCARB GIS database (also known as the carbon atlas) stores layers of geologic information about potential underground storage sites, such as porosity and nearby fault-lines and aquifers. Researchers use these data, along with interpreted geophysical data and available oil and gas well logs to estimate the region's potential geologic storage capacity. The database also depicts existing pipeline routes and rights-of-way and lands that could be off-limits, which can aid the development of a regional carbon management strategy. The WESTCARB Carbon Atlas, which is accessible to the public, provides a resource for public discourse on practical solutions for regional CO2 management. A key WESTCARB partner, the Utah Automated Geographic Reference Center, has developed data serving procedures to enable the WESTCARB Carbon Atlas to be integrated with those from other regional partnerships, thereby supporting the U.S. Department of Energy's national carbon atlas, NATCARB

  20. Chandra Galaxy Atlas

    NASA Astrophysics Data System (ADS)

    Kim, Dong-Woo; Anderson, Craig; Burke, Doug; Fabbiano, Giuseppina; Fruscione, Antonella; Lauer, Jennifer L.; McCollough, Michael L.; Morgan, Doug; Mossman, Amy; O'Sullivan, Ewan; Paggi, Alessandro; Trinchieri, Ginevra

    2016-01-01

    We present the new results from the Chandra Galaxy Atlas prpject. We have systematically analyzed the archival Chandra data of 50 early type galaxies to study their hot ISM. Taking full advantage of the Chandra capabilities, we produced spatially resolved data products with additional spectral information. We will make these products publicly available and use them for our focused science goals, e.g., gas morphology, scaling relation, X-ray based mass profile, circum-nuclear gas.

  1. Topographical atlas sheets

    USGS Publications Warehouse

    Wheeler, George Montague

    1877-01-01

    The following topographical atlas maps, published during the year, accompany the copies of Appendix N.N. of the Annual Report of the Chief of Engineers for 1877, beinig Annual Report of Lieut. Geo. M. Wheeler, Corps of Engineers, in charge of U. S. Geographical Surveys, are in continuation of the series ninety-five in number, on a scale of 1 inch to 8 miles, embracing the territory of the United States lying west of the 100th meridian.

  2. Topographical atlas sheets

    USGS Publications Warehouse

    Wheeler, George Montague

    1876-01-01

    The following topographical atlas sheets, accompanying Appendix J.J. of the Annual Report of the Chief of Engineers, U.S. Army-being Annual Report upon U. S. Geographical Surveys-have been published during the fiscal year ending June 30, 1876, and are a portion of the series projected to embrace the territory of the United States lying west of the 100th meridian.

  3. Dissociating barrel development and lesion-induced plasticity in the mouse somatosensory cortex.

    PubMed

    Rebsam, Alexandra; Seif, Isabelle; Gaspar, Patricia

    2005-01-19

    In the mouse somatosensory cortex, thalamocortical axons (TCAs) corresponding to individual whiskers cluster into restricted barrel domains during the first days of life. If whiskers are lesioned before that time, the cortical space devoted to the afferents from the damaged whisker shrinks and becomes occupied by thalamocortical afferents from neighboring unlesioned whiskers. This plasticity ends by postnatal day 3 (P3) to P4 when barrels emerge. To test whether TCA development and lesion-induced plasticity are linked, we used monoamine oxidase A knock-out (MAOA-KO) mice in which normal TCA development is halted by an excess of serotonin. Normal TCA development can be restored when serotonin levels are lowered by parachlorophenylalanine (PCPA). By varying the time of PCPA administration, we found that barrel development can be reinitiated until P11, although the emergence of TCA clusters becomes gradually slower and less complete. In mice in which barrels emerge 3 d later than the normal schedule, at P6 instead of P3, we examined lesion-induced plasticity. We find a progressive decline of the lesion-induced plasticity and a closure at P3, similar to normal mice, showing that this plasticity is not influenced by an excess of serotonin levels. Thus, in MAOA-KO mice, the emergence of barrel patterning can be delayed without a concomitant delay in lesion-induced plasticity, and the cortical space devoted to one whisker representation cannot be modified by the periphery once patterning is imprinted in the subcortical relays. We conclude that the closure of the lesion-induced plasticity period in the barrelfield is probably not determined at the cortical level. PMID:15659608

  4. Differential columnar processing in local circuits of barrel and insular cortices.

    PubMed

    Sato, Hajime; Shimanuki, Yasushi; Saito, Mitsuru; Toyoda, Hiroki; Nokubi, Takashi; Maeda, Yoshinobu; Yamamoto, Takashi; Kang, Youngnam

    2008-03-19

    The columnar organization is most apparent in the whisker barrel cortex but seems less apparent in the gustatory insular cortex. We addressed here whether there are any differences between the two cortices in columnar information processing by comparing the spatiotemporal patterns of excitation spread in the two cortices using voltage-sensitive dye imaging. In contrast to the well known excitation spread in the horizontal direction in layer II/III induced in the barrel cortex by layer IV stimulation, the excitation caused in the insular cortex by stimulation of layer IV spread bidirectionally in the vertical direction into layers II/III and V/VI, displaying a columnar image pattern. Bicuculline or picrotoxin markedly extended the horizontal excitation spread in layer II/III in the barrel cortex, leading to a generation of excitation in the underlying layer V/VI, whereas those markedly increased the amplitude of optical responses throughout the whole column in the insular cortex, subsequently widening the columnar image pattern. Such synchronous activities as revealed by the horizontal and vertical excitation spreads were consistently induced in the barrel and insular cortices, respectively, even by stimulation of different layers with varying intensities. Thus, a unique functional column existed in the insular cortex, in which intracolumnar communication between the superficial and deep layers was prominent, and GABA(A) action is involved in the inhibition of the intracolumnar communication in contrast to its involvement in intercolumnar lateral inhibition in the barrel cortex. These results suggest that the columnar information processing may not be universal across the different cortical areas. PMID:18354011

  5. All-atom 3D structure prediction of transmembrane β-barrel proteins from sequences

    PubMed Central

    Hayat, Sikander; Sander, Chris; Marks, Debora S.

    2015-01-01

    Transmembrane β-barrels (TMBs) carry out major functions in substrate transport and protein biogenesis but experimental determination of their 3D structure is challenging. Encouraged by successful de novo 3D structure prediction of globular and α-helical membrane proteins from sequence alignments alone, we developed an approach to predict the 3D structure of TMBs. The approach combines the maximum-entropy evolutionary coupling method for predicting residue contacts (EVfold) with a machine-learning approach (boctopus2) for predicting β-strands in the barrel. In a blinded test for 19 TMB proteins of known structure that have a sufficient number of diverse homologous sequences available, this combined method (EVfold_bb) predicts hydrogen-bonded residue pairs between adjacent β-strands at an accuracy of ∼70%. This accuracy is sufficient for the generation of all-atom 3D models. In the transmembrane barrel region, the average 3D structure accuracy [template-modeling (TM) score] of top-ranked models is 0.54 (ranging from 0.36 to 0.85), with a higher (44%) number of residue pairs in correct strand–strand registration than in earlier methods (18%). Although the nonbarrel regions are predicted less accurately overall, the evolutionary couplings identify some highly constrained loop residues and, for FecA protein, the barrel including the structure of a plug domain can be accurately modeled (TM score = 0.68). Lower prediction accuracy tends to be associated with insufficient sequence information and we therefore expect increasing numbers of β-barrel families to become accessible to accurate 3D structure prediction as the number of available sequences increases. PMID:25858953

  6. Development and test of the DAQ system for a Micromegas prototype to be installed in the ATLAS experiment

    NASA Astrophysics Data System (ADS)

    Bianco, M.; Martoiu, S.; Sidiropoulou, O.; Zibell, A.

    2015-12-01

    A Micromegas (MM) quadruplet prototype with an active area of 0.5 m2 that adopts the general design foreseen for the upgrade of the innermost forward muon tracking systems (Small Wheels) of the ATLAS detector in 2018-2019, has been built at CERN and is going to be tested in the ATLAS cavern environment during the LHC RUN-II period 2015-2017. The integration of this prototype detector into the ATLAS data acquisition system using custom ATCA equipment is presented. An ATLAS compatible Read Out Driver (ROD) based on the Scalable Readout System (SRS), the Scalable Readout Unit (SRU), will be used in order to transmit the data after generating valid event fragments to the high-level Read Out System (ROS). The SRU will be synchronized with the LHC bunch crossing clock (40.08 MHz) and will receive the Level-1 trigger signals from the Central Trigger Processor (CTP) through the TTCrx receiver ASIC. The configuration of the system will be driven directly from the ATLAS Run Control System. By using the ATLAS TDAQ Software, a dedicated Micromegas segment has been implemented, in order to include the detector inside the main ATLAS DAQ partition. A full set of tests, on the hardware and software aspects, is presented.

  7. Assembly of the β-Barrel Outer Membrane Proteins in Gram-Negative Bacteria, Mitochondria, and Chloroplasts

    PubMed Central

    Misra, Rajeev

    2012-01-01

    In the last decade, there has been an explosion of publications on the assembly of β-barrel outer membrane proteins (OMPs), which carry out diverse cellular functions, including solute transport, protein secretion, and assembly of protein and lipid components of the outer membrane. Of the three outer membrane model systems—Gram-negative bacteria, mitochondria and chloroplasts—research on bacterial and mitochondrial systems has so far led the way in dissecting the β-barrel OMP assembly pathways. Many exciting discoveries have been made, including the identification of β-barrel OMP assembly machineries in bacteria and mitochondria, and potentially the core assembly component in chloroplasts. The atomic structures of all five components of the bacterial β-barrel assembly machinery (BAM) complex, except the β-barrel domain of the core BamA protein, have been solved. Structures reveal that these proteins contain domains/motifs known to facilitate protein-protein interactions, which are at the heart of the assembly pathways. While structural information has been valuable, most of our current understanding of the β-barrel OMP assembly pathways has come from genetic, molecular biology, and biochemical analyses. This paper provides a comparative account of the β-barrel OMP assembly pathways in Gram-negative bacteria, mitochondria, and chloroplasts.

  8. A Supercomplex Spanning the Inner and Outer Membranes Mediates the Biogenesis of β-Barrel Outer Membrane Proteins in Bacteria.

    PubMed

    Wang, Yan; Wang, Rui; Jin, Feng; Liu, Yang; Yu, Jiayu; Fu, Xinmiao; Chang, Zengyi

    2016-08-01

    β-barrel outer membrane proteins (OMPs) are ubiquitously present in Gram-negative bacteria, mitochondria and chloroplasts, and function in a variety of biological processes. The mechanism by which the hydrophobic nascent β-barrel OMPs are transported through the hydrophilic periplasmic space in bacterial cells remains elusive. Here, mainly via unnatural amino acid-mediated in vivo photo-crosslinking studies, we revealed that the primary periplasmic chaperone SurA interacts with nascent β-barrel OMPs largely via its N-domain but with β-barrel assembly machine protein BamA mainly via its satellite P2 domain, and that the nascent β-barrel OMPs interact with SurA via their N- and C-terminal regions. Additionally, via dual in vivo photo-crosslinking, we demonstrated the formation of a ternary complex involving β-barrel OMP, SurA, and BamA in cells. More importantly, we found that a supercomplex spanning the inner and outer membranes and involving the BamA, BamB, SurA, PpiD, SecY, SecE, and SecA proteins appears to exist in living cells, as revealed by a combined analyses of sucrose-gradient ultra-centrifugation, Blue native PAGE and mass spectrometry. We propose that this supercomplex integrates the translocation, transportation, and membrane insertion events for β-barrel OMP biogenesis. PMID:27298319

  9. Consumer demand for green stormwater management technology in an urban setting: The case of Chicago rain barrels

    NASA Astrophysics Data System (ADS)

    Ando, Amy W.; Freitas, Luiz P. C.

    2011-12-01

    Hydrological disruption and water pollution from urbanization can be reduced if households in urban areas adopt decentralized storm water controls. We study a citywide municipal subsidized rain-barrel program in the third biggest city in the United States, Chicago, to explore what factors influence whether households purchase this sort of green storm water management technology in an urban setting. Specifically, we regress census-tract level data on the number of rain barrels adopted in different parts of the city on socioeconomic variables, data on local flood frequency, and features of the housing stock. We find that rain-barrel purchases are not correlated with local levels of flooding, even though city residents were told by program managers that rain barrels could alleviate local flooding. Instead, rain barrels are heavily concentrated in places with high-income attitudinally green populations. We do find more rain barrels were adopted in places close to rain-barrel distribution points and near sites of hydrological information campaigns; thus, policy makers might increase green-technology adoption in areas where they can do the most good by reducing transaction costs and providing education programs to those areas. Finally, our results indicate that owner occupancy is positively correlated with green-technology adoption. Low-rise rental housing may have inefficiently low levels of adoption, such that city managers might want to develop programs to encourage storm water management investments by landlords who do not live in their own properties.

  10. ATLAS 1: Encountering Planet Earth

    NASA Technical Reports Server (NTRS)

    Shea, Charlotte; Mcmahan, Tracy; Accardi, Denise; Tygielski, Michele; Mikatarian, Jeff; Wiginton, Margaret (Editor)

    1984-01-01

    Several NASA science programs examine the dynamic balance of sunlight, atmosphere, water, land, and life that governs Earth's environment. Among these is a series of Space Shuttle-Spacelab missions, named the Atmospheric Laboratory for Applications and Science (ATLAS). During the ATLAS missions, international teams of scientists representing many disciplines combine their expertise to seek answers to complex questions about the atmospheric and solar conditions that sustain life on Earth. The ATLAS program specifically investigates how Earth's middle atmosphere and upper atmospheres and climate are affected by both the Sun and by products of industrial and agricultural activities on Earth.

  11. Automated Loads Analysis System (ATLAS)

    NASA Technical Reports Server (NTRS)

    Gardner, Stephen; Frere, Scot; O’Reilly, Patrick

    2013-01-01

    ATLAS is a generalized solution that can be used for launch vehicles. ATLAS is used to produce modal transient analysis and quasi-static analysis results (i.e., accelerations, displacements, and forces) for the payload math models on a specific Shuttle Transport System (STS) flight using the shuttle math model and associated forcing functions. This innovation solves the problem of coupling of payload math models into a shuttle math model. It performs a transient loads analysis simulating liftoff, landing, and all flight events between liftoff and landing. ATLAS utilizes efficient and numerically stable algorithms available in MSC/NASTRAN.

  12. Cobalamin-Independent Methionine Synthase (MetE): A Face-to-Face Double Barrel that Evolved by Gene Duplication

    SciTech Connect

    Pejcha, Robert; Ludwig, Martha L.

    2010-03-08

    Cobalamin-independent methionine synthase (MetE) catalyzes the transfer of a methyl group from methyltetrahydrofolate to L-homocysteine (Hcy) without using an intermediate methyl carrier. Although MetE displays no detectable sequence homology with cobalamin-dependent methionine synthase (MetH), both enzymes require zinc for activation and binding of Hcy. Crystallographic analyses of MetE from T. maritima reveal an unusual dual-barrel structure in which the active site lies between the tops of the two ({beta}{alpha}){sub 8} barrels. The fold of the N-terminal barrel confirms that it has evolved from the C-terminal polypeptide by gene duplication; comparisons of the barrels provide an intriguing example of homologous domain evolution in which binding sites are obliterated. The C-terminal barrel incorporates the zinc ion that binds and activates Hcy. The zinc-binding site in MetE is distinguished from the (Cys){sub 3}Zn site in the related enzymes, MetH and betaine-homocysteine methyltransferase, by its position in the barrel and by the metal ligands, which are histidine, cysteine, glutamate, and cysteine in the resting form of MetE. Hcy associates at the face of the metal opposite glutamate, which moves away from the zinc in the binary E {center_dot} Hcy complex. The folate substrate is not intimately associated with the N-terminal barrel; instead, elements from both barrels contribute binding determinants in a binary complex in which the folate substrate is incorrectly oriented for methyl transfer. Atypical locations of the Hcy and folate sites in the C-terminal barrel presumably permit direct interaction of the substrates in a ternary complex. Structures of the binary substrate complexes imply that rearrangement of folate, perhaps accompanied by domain rearrangement, must occur before formation of a ternary complex that is competent for methyl transfer.

  13. Cobalamin-Independent Methionine Synthase (MetE): A Face-to-Face Double Barrel That Evolved by Gene Duplication

    PubMed Central

    2005-01-01

    Cobalamin-independent methionine synthase (MetE) catalyzes the transfer of a methyl group from methyltetrahydrofolate to L-homocysteine (Hcy) without using an intermediate methyl carrier. Although MetE displays no detectable sequence homology with cobalamin-dependent methionine synthase (MetH), both enzymes require zinc for activation and binding of Hcy. Crystallographic analyses of MetE from T. maritima reveal an unusual dual-barrel structure in which the active site lies between the tops of the two (βα)8 barrels. The fold of the N-terminal barrel confirms that it has evolved from the C-terminal polypeptide by gene duplication; comparisons of the barrels provide an intriguing example of homologous domain evolution in which binding sites are obliterated. The C-terminal barrel incorporates the zinc ion that binds and activates Hcy. The zinc-binding site in MetE is distinguished from the (Cys)3Zn site in the related enzymes, MetH and betaine–homocysteine methyltransferase, by its position in the barrel and by the metal ligands, which are histidine, cysteine, glutamate, and cysteine in the resting form of MetE. Hcy associates at the face of the metal opposite glutamate, which moves away from the zinc in the binary E·Hcy complex. The folate substrate is not intimately associated with the N-terminal barrel; instead, elements from both barrels contribute binding determinants in a binary complex in which the folate substrate is incorrectly oriented for methyl transfer. Atypical locations of the Hcy and folate sites in the C-terminal barrel presumably permit direct interaction of the substrates in a ternary complex. Structures of the binary substrate complexes imply that rearrangement of folate, perhaps accompanied by domain rearrangement, must occur before formation of a ternary complex that is competent for methyl transfer. PMID:15630480

  14. ATLAS software packaging

    NASA Astrophysics Data System (ADS)

    Rybkin, Grigory

    2012-12-01

    Software packaging is indispensable part of build and prerequisite for deployment processes. Full ATLAS software stack consists of TDAQ, HLT, and Offline software. These software groups depend on some 80 external software packages. We present tools, package PackDist, developed and used to package all this software except for TDAQ project. PackDist is based on and driven by CMT, ATLAS software configuration and build tool, and consists of shell and Python scripts. The packaging unit used is CMT project. Each CMT project is packaged as several packages—platform dependent (one per platform available), source code excluding header files, other platform independent files, documentation, and debug information packages (the last two being built optionally). Packaging can be done recursively to package all the dependencies. The whole set of packages for one software release, distribution kit, also includes configuration packages and contains some 120 packages for one platform. Also packaged are physics analysis projects (currently 6) used by particular physics groups on top of the full release. The tools provide an installation test for the full distribution kit. Packaging is done in two formats for use with the Pacman and RPM package managers. The tools are functional on the platforms supported by ATLAS—GNU/Linux and Mac OS X. The packaged software is used for software deployment on all ATLAS computing resources from the detector and trigger computing farms, collaboration laboratories computing centres, grid sites, to physicist laptops, and CERN VMFS and covers the use cases of running all applications as well as of software development.

  15. Exotics Searches with Atlas

    NASA Astrophysics Data System (ADS)

    Tykhonov, Andrii

    2015-03-01

    An overview is presented for the non-SUSY searches for New Physics with the ATLAS detector. The results presented use data collected at centerof-mass energies of √ s = 7 TeV and √ s = 8 TeV, for data sets corresponding to a variety of integrated luminosities. Searches using leptons, photons, missing transverse energy, and jets are performed, as well as searches requiring custom jet and track reconstruction, and searches for the so-called lepton jets. No deviations from Standard Model expectations are observed, hence constraints are placed on the phase space of available theoretical models.

  16. CP violation at ATLAS

    NASA Astrophysics Data System (ADS)

    Barton, Adam; Atlas Collaboration

    2013-07-01

    A measurement of several properties of the Bs meson, including the CP-violating weak phase phis and the mixing-induced width difference ΔΓs, is performed using the decay Bs → J/ψ(μ+μ-)phi(K+K-), from a dataset of 4.9 fb-1 of integrated luminosity collected in 2011 by the ATLAS detector at the LHC. The measured parameters are consistent with the world average values and theoretical expectations; in particular phis is within 1 σ of the expected value in the Standard Model.

  17. Alaska marine ice atlas

    SciTech Connect

    LaBelle, J.C.; Wise, J.L.; Voelker, R.P.; Schulze, R.H.; Wohl, G.M.

    1982-01-01

    A comprehensive Atlas of Alaska marine ice is presented. It includes information on pack and landfast sea ice and calving tidewater glacier ice. It also gives information on ice and related environmental conditions collected over several years time and indicates the normal and extreme conditions that might be expected in Alaska coastal waters. Much of the information on ice conditions in Alaska coastal waters has emanated from research activities in outer continental shelf regions under assessment for oil and gas exploration and development potential. (DMC)

  18. Formation of furfurylthiol exhibiting a strong coffee aroma during oak barrel fermentation from furfural released by toasted staves.

    PubMed

    Blanchard, L; Tominaga, T; Dubourdieu, D

    2001-10-01

    Furfurylthiol (FFT) is formed in white wines during alcoholic fermentation in the barrel from the furfural released by toasted staves. The quantity of furfural released into the must has a decisive effect on the quantity of FFT in the finished wine. Wines fermented in new barrels thus contain larger quantities of FFT than those fermented in used barrels. Fermentation conditions favorable to an excess production of H(2)S (hydrogen sulfide) by the yeast promote the formation of this volatile thiol. The presence of this volatile thiol in white wines is, therefore, closely related to the yeast's sulfur metabolism. PMID:11600030

  19. MarsAtlas: A cortical parcellation atlas for functional mapping.

    PubMed

    Auzias, Guillaume; Coulon, Olivier; Brovelli, Andrea

    2016-04-01

    An open question in neuroimaging is how to develop anatomical brain atlases for the analysis of functional data. Here, we present a cortical parcellation model based on macroanatomical information and test its validity on visuomotor-related cortical functional networks. The parcellation model is based on a recently developed cortical parameterization method (Auzias et al., [2013]: IEEE Trans Med Imaging 32:873-887), called HIP-HOP. This method exploits a set of primary and secondary sulci to create an orthogonal coordinate system on the cortical surface. A natural parcellation scheme arises from the axes of the HIP-HOP model running along the fundus of selected sulci. The resulting parcellation scheme, called MarsAtlas, complies with dorsoventral/rostrocaudal direction fields and allows inter-subject matching. To test it for functional mapping, we analyzed a MEG dataset collected from human participants performing an arbitrary visuomotor mapping task. Single-trial high-gamma activity, HGA (60-120 Hz), was estimated using spectral analysis and beamforming techniques at cortical areas arising from a Talairach atlas (i.e., Brodmann areas) and MarsAtlas. Using both atlases, we confirmed that visuomotor associations involve an increase in HGA over the sensorimotor and fronto-parietal network, in addition to medial prefrontal areas. However, MarsAtlas provided: (1) crucial functional information along both the dorsolateral and rostrocaudal direction; (2) an increase in statistical significance. To conclude, our results suggest that the MarsAtlas is a valid anatomical atlas for functional mapping, and represents a potential anatomical framework for integration of functional data arising from multiple techniques such as MEG, intracranial EEG and fMRI. PMID:26813563

  20. a Barrel Ifr Instrumented with Limited Streamer Tubes for Babar Experiment

    NASA Astrophysics Data System (ADS)

    Cibinetto, Gianluigi

    The new barrel Instrumented Flux Return (IFR) of BABAR detector will be reported here. Limited Stramer Tubes (LSTs) have been chosen to replace the existing RPCs as active elements of the barrel IFR. The layout of the new detector will be discussed: in particular, a cell bigger than the standard one has been used to improve efficiency and reliability. The extruded profile is coated with a resistive layer of graphite having a typical surface resistivity between 0.2 and 0.4 MOhm/square. The tubes are assembled in modules and installed in 12 active layers of each sextant of the IFR detector. R&D studies which have been done to choose the final design will be discussed, as well as the Quality Control procedure adopted during the tube production to assure high performances of the detector.

  1. A Barrel IFR Instrumented With Limited Streamer Tubes for BABAR Experiment

    SciTech Connect

    Andreotti, M.; /Ferrara U. /INFN, Ferrara

    2006-11-15

    The new barrel Instrumented Flux Return (IFR) of BABAR detector will be reported here. Limited Streamer Tubes (LSTs) have been chosen to replace the existing RPCs as active elements of the barrel IFR. The layout of the new detector will be discussed: in particular, a cell bigger than the standard one has been used to improve efficiency and reliability. The extruded profile is coated with a resistive layer of graphite having a typical surface resistivity between 0.2 and 0.4 MOhm/square. The tubes are assembled in modules and installed in 12 active layers of each sextant of the IFR detector. R&D studies to choose the final design and Quality Control procedure adopted during the tube production will be briefly discussed. Finally the performances of installed LSTs into 2/3 of IFR after 8 months of operations will be reported.

  2. a Barrel Ifr Instrumented with Limited Streamer Tubes for Babar Experiment

    NASA Astrophysics Data System (ADS)

    Andreotti, Mirco

    2006-04-01

    The new barrel Instrumented Flux Return (IFR) of BABAR detector will be reported here. Limited Streamer Tubes (LSTs) have been chosen to replace the existing RPCs as active elements of the barrel IFR. The layout of the new detector will be discussed: in particular, a cell bigger than the standard one has been used to improve efficiency and reliability. The extruded profile is coated with a resistive layer of graphite having a typical surface resistivity between 0.2 and 0.4 MOhm/square. The tubes are assembled in modules and installed in 12 active layers of each sextant of the IFR detector. R&D studies to choose the final design and Quality Control procedure adopted during the tube production will be briefly discussed. Finally the performances of installed LSTs into 2/3 of IFR after 8 months of operations will be reported.

  3. TMB-Hunt: a web server to screen sequence sets for transmembrane beta-barrel proteins.

    PubMed

    Garrow, Andrew G; Agnew, Alison; Westhead, David R

    2005-07-01

    TMB-Hunt is a program that uses a modified k-nearest neighbour (k-NN) algorithm to classify protein sequences as transmembrane beta-barrel (TMB) or non-TMB on the basis of whole sequence amino acid composition. By including differentially weighted amino acids, evolutionary information and by calibrating the scoring, a discrimination accuracy of 92.5% was achieved, as tested using a rigorous cross-validation procedure. The TMB-Hunt web server, available at www.bioinformatics.leeds.ac.uk/betaBarrel, allows screening of up to 10,000 sequences in a single query and provides results and key statistics in a simple colour coded format. PMID:15980452

  4. Influence of Flow Swirling and Exit Shape of Barrel Nozzle on Cold Spraying

    NASA Astrophysics Data System (ADS)

    Klinkov, S. V.; Kosarev, V. F.; Zaikovskii, V. N.

    2011-06-01

    Traditionally, in cold spray two-phase supersonic jet formed with the help of converging-diverging nozzle are used. In this study an alternative design of cold spray nozzle is proposed in which a high velocity two-phase flow is created using an intense flow swirling in a constant section barrel (cylinder) with double-edged bevel exit. As a result, a high velocity gas-powder mixture jet is produced presenting a fan-shaped jet spreading at a large angle in one plane and approximately of equal size along the normal to this plane. This results in greater angles of particle deposition and, hence, in larger deposition widths, with the maximum width of deposition spot reaching 25 barrel diameters. The performed experimental study proves the new nozzle design to be appropriate for deposition of cold-sprayed coatings.

  5. Synaptic molecular imaging in spared and deprived columns of mouse barrel cortex with array tomography

    PubMed Central

    Weiler, Nicholas C; Collman, Forrest; Vogelstein, Joshua T; Burns, Randal; Smith, Stephen J

    2014-01-01

    A major question in neuroscience is how diverse subsets of synaptic connections in neural circuits are affected by experience dependent plasticity to form the basis for behavioral learning and memory. Differences in protein expression patterns at individual synapses could constitute a key to understanding both synaptic diversity and the effects of plasticity at different synapse populations. Our approach to this question leverages the immunohistochemical multiplexing capability of array tomography (ATomo) and the columnar organization of mouse barrel cortex to create a dataset comprising high resolution volumetric images of spared and deprived cortical whisker barrels stained for over a dozen synaptic molecules each. These dataset has been made available through the Open Connectome Project for interactive online viewing, and may also be downloaded for offline analysis using web, Matlab, and other interfaces. PMID:25977797

  6. Synaptic molecular imaging in spared and deprived columns of mouse barrel cortex with array tomography.

    PubMed

    Weiler, Nicholas C; Collman, Forrest; Vogelstein, Joshua T; Burns, Randal; Smith, Stephen J

    2014-01-01

    A major question in neuroscience is how diverse subsets of synaptic connections in neural circuits are affected by experience dependent plasticity to form the basis for behavioral learning and memory. Differences in protein expression patterns at individual synapses could constitute a key to understanding both synaptic diversity and the effects of plasticity at different synapse populations. Our approach to this question leverages the immunohistochemical multiplexing capability of array tomography (ATomo) and the columnar organization of mouse barrel cortex to create a dataset comprising high resolution volumetric images of spared and deprived cortical whisker barrels stained for over a dozen synaptic molecules each. These dataset has been made available through the Open Connectome Project for interactive online viewing, and may also be downloaded for offline analysis using web, Matlab, and other interfaces. PMID:25977797

  7. The β-barrel membrane protein insertase machinery from Gram-negative bacteria

    PubMed Central

    Noinaj, Nicholas; Rollauer, Sarah E.; Buchanan, Susan K.

    2015-01-01

    The outer membranes (OM) of Gram-negative bacteria contain a host of β-barrel outer membrane proteins (OMPs) which serve many functions for cell survival and virulence. The biogenesis of these OMPs is mediated by the β-barrel assembly machinery (BAM) complex which is composed of five components including the essential core component called BamA that mediates the insertase function within the OM. The crystal structure of BamA has recently been reported from three different species, including a full-length structure from Neisseria gonorrhoeae. Mutagenesis and functional studies identified several conformational changes within BamA that are required for function, providing a significant advancement towards unraveling exactly how BamA and the BAM complex are able to fold and insert new OMPs in the OM. PMID:25796031

  8. Reversibility and two state behaviour in the thermal unfolding of oligomeric TIM barrel proteins.

    PubMed

    Romero-Romero, Sergio; Costas, Miguel; Rodríguez-Romero, Adela; Alejandro Fernández-Velasco, D

    2015-08-28

    Temperature is one of the main variables that modulate protein function and stability. Thermodynamic studies of oligomeric proteins, the dominant protein natural form, have been often hampered because irreversible aggregation and/or slow reactions are common. There are no reports on the reversible equilibrium thermal unfolding of proteins composed of (β/α)8 barrel subunits, albeit this "TIM barrel" topology is one of the most abundant and versatile in nature. We studied the eponymous TIM barrel, triosephosphate isomerase (TIM), belonging to five species of different bacterial taxa. All of them were found to be catalytically efficient dimers. The three-dimensional structure of four enzymes was solved at high/medium resolution. Irreversibility and kinetic control were observed in the thermal unfolding of two TIMs, while for the other three the thermal unfolding was found to follow a two-state equilibrium reversible process. Shifts in the global stability curves of these three proteins are related to the organismal temperature range of optimal growth and modulated by variations in maximum stability temperature and in the enthalpy change at that temperature. Reversibility appears to correlate with the low isoelectric point, the absence of a residual structure in the unfolded state, small cavity volume in the native state, low conformational stability and a low melting temperature. Furthermore, the strong coupling between dimer dissociation and monomer unfolding may reduce aggregation and favour reversibility. It is therefore very thought-provoking to find that a common topological ensemble, such as the TIM barrel, can unfold/refold in the Anfinsen way, i.e. without the help of the cellular machinery. PMID:26206330

  9. Cofilin1 Controls Transcolumnar Plasticity in Dendritic Spines in Adult Barrel Cortex

    PubMed Central

    Tsubota, Tadashi; Okubo-Suzuki, Reiko; Ohashi, Yohei; Tamura, Keita; Ogata, Koshin; Yaguchi, Masae; Matsuyama, Makoto; Inokuchi, Kaoru; Miyashita, Yasushi

    2015-01-01

    During sensory deprivation, the barrel cortex undergoes expansion of a functional column representing spared inputs (spared column), into the neighboring deprived columns (representing deprived inputs) which are in turn shrunk. As a result, the neurons in a deprived column simultaneously increase and decrease their responses to spared and deprived inputs, respectively. Previous studies revealed that dendritic spines are remodeled during this barrel map plasticity. Because cofilin1, a predominant regulator of actin filament turnover, governs both the expansion and shrinkage of the dendritic spine structure in vitro, it hypothetically regulates both responses in barrel map plasticity. However, this hypothesis remains untested. Using lentiviral vectors, we knocked down cofilin1 locally within layer 2/3 neurons in a deprived column. Cofilin1-knocked-down neurons were optogenetically labeled using channelrhodopsin-2, and electrophysiological recordings were targeted to these knocked-down neurons. We showed that cofilin1 knockdown impaired response increases to spared inputs but preserved response decreases to deprived inputs, indicating that cofilin1 dependency is dissociated in these two types of barrel map plasticity. To explore the structural basis of this dissociation, we then analyzed spine densities on deprived column dendritic branches, which were supposed to receive dense horizontal transcolumnar projections from the spared column. We found that spine number increased in a cofilin1-dependent manner selectively in the distal part of the supragranular layer, where most of the transcolumnar projections existed. Our findings suggest that cofilin1-mediated actin dynamics regulate functional map plasticity in an input-specific manner through the dendritic spine remodeling that occurs in the horizontal transcolumnar circuits. These new mechanistic insights into transcolumnar plasticity in adult rats may have a general significance for understanding reorganization of

  10. Particle contamination from Martin Optical Black. [in design of barrel baffle of Infrared Astronomical Satellite

    NASA Technical Reports Server (NTRS)

    Young, P. J.; Noll, R.; Andreozzi, L.; Hope, J.

    1981-01-01

    The design of the barrel baffle of the Infrared Astronomical Satellite (IRAS) Optical Subsystem to minimize production of particulate contamination is described. The configuration of the 50-inch long, 28.5-inch diameter baffle required pop-rivet assembly after coating with Martin Optical Black for stray light suppression. An experiment to determine the contamination produced at assembly led to the modification of the baffle construction to preclude such damage to the coated surfaces.

  11. BARREL observations of a solar energetic electron and solar energetic proton event

    NASA Astrophysics Data System (ADS)

    Halford, A. J.; McGregor, S. L.; Hudson, M. K.; Millan, R. M.; Kress, B. T.

    2016-05-01

    During the second Balloon Array for Radiation Belt Relativistic Electron Losses (BARREL) campaign two solar energetic proton (SEP) events were observed. Although BARREL was designed to observe X-rays created during electron precipitation events, it is sensitive to X-rays from other sources. The gamma lines produced when energetic protons hit the upper atmosphere are used in this paper to study SEP events. During the second SEP event starting on 7 January 2014 and lasting ˜3 days, which also had a solar energetic electron (SEE) event occurring simultaneously, BARREL had six payloads afloat spanning all magnetic local time (MLT) sectors and L values. Three payloads were in a tight array (˜2 h in MLT and ˜2 ΔL) inside the inner magnetosphere and at times conjugate in both L and MLT with the Van Allen Probes (approximately once per day). The other three payloads mapped to higher L values with one payload on open field lines for the entire event, while the other two appear to be crossing from open to closed field lines. Using the observations of the SEE and SEP events, we are able to map the open-closed boundary. Halford et al. (2015) demonstrated how BARREL can monitor electron precipitation following an interplanetary shock created by a coronal mass ejection (ICME-shock) arrival at Earth, while in this study we look at the SEP event precursor to the arrival of the ICME-Shock in our cradle-to-grave view: from flare, to SEE and SEP events, to radiation belt electron precipitation.

  12. Performance study of the CMS barrel resistive plate chambers with cosmic rays

    NASA Astrophysics Data System (ADS)

    CMS Collaboration

    2010-03-01

    In October and November 2008, the CMS collaboration conducted a programme of cosmic ray data taking, which has recorded about 270 million events. The Resistive Plate Chamber system, which is part of the CMS muon detection system, was successfully operated in the full barrel. More than 98% of the channels were operational during the exercise with typical detection efficiency of 90%. In this paper, the performance of the detector during these dedicated runs is reported.

  13. A 30degree 'barrel shot' taken at track level showing operator's ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    A 30-degree 'barrel shot' taken at track level showing operator's house in center of swing span and the track with timber ties. The ties are transverse (90-degree) to the track with each end resting on the bottom chord of the steel swing span truss, thus providing their support with live loads being transferred to the swing span truss bridge. - Bridgeport Swing Span Bridge, Spanning Tennessee River, Bridgeport, Jackson County, AL

  14. Double-barreled and Concentric Microelectrodes for Measurement of Extracellular Ion Signals in Brain Tissue

    PubMed Central

    Haack, Nicole; Durry, Simone; Kafitz, Karl W.; Chesler, Mitchell; Rose, Christine R.

    2015-01-01

    Electrical activity in the brain is accompanied by significant ion fluxes across membranes, resulting in complex changes in the extracellular concentration of all major ions. As these ion shifts bear significant functional consequences, their quantitative determination is often required to understand the function and dysfunction of neural networks under physiological and pathophysiological conditions. In the present study, we demonstrate the fabrication and calibration of double-barreled ion-selective microelectrodes, which have proven to be excellent tools for such measurements in brain tissue. Moreover, so-called “concentric” ion-selective microelectrodes are also described, which, based on their different design, offer a far better temporal resolution of fast ion changes. We then show how these electrodes can be employed in acute brain slice preparations of the mouse hippocampus. Using double-barreled, potassium-selective microelectrodes, changes in the extracellular potassium concentration ([K+]o) in response to exogenous application of glutamate receptor agonists or during epileptiform activity are demonstrated. Furthermore, we illustrate the response characteristics of sodium-sensitive, double-barreled and concentric electrodes and compare their detection of changes in the extracellular sodium concentration ([Na+]o) evoked by bath or pressure application of drugs. These measurements show that while response amplitudes are similar, the concentric sodium microelectrodes display a superior signal-to-noise ratio and response time as compared to the double-barreled design. Generally, the demonstrated procedures will be easily transferable to measurement of other ions species, including pH or calcium, and will also be applicable to other preparations. PMID:26381747

  15. Nitrobindin: An Ubiquitous Family of All β-Barrel Heme-proteins.

    PubMed

    De Simone, Giovanna; Ascenzi, Paolo; Polticelli, Fabio

    2016-06-01

    Rhodnius prolixus nitrophorins (Rp-NPs), Arabidopsis thaliana nitrobindin (At-Nb), and Homo sapiens THAP4 (Hs-THAP4) are the unique known proteins that use a β-barrel fold to bind ferric heme, which is devoted to NO transport and/or catalysis. The eight-stranded antiparallel β-barrel Rp-NPs, which represent the only heme-binding lipocalins, are devoted to deliver NO into the blood vessel of the host and to scavenge histamine during blood sucking. Regarding Nbs, crystallographic data suggest the ability of At-Nb and Hs-THAP4 to bind ferric heme; however, no data are available with respect to these functions in the natural host. Here, a bioinformatics investigation based on the amino acid sequences and three-dimensional structures of At-Nb and Hs-THAP4 suggests a conservation of the 10-stranded antiparallel β-barrel Nb structural module in all life kingdoms of the evolutionary ladder. In particular, amino acid residues involved in the heme recognition and in the structure stabilization of the Nb structural module are highly conserved (identity > 29%; homology > 83%). Moreover, molecular models of putative Nbs from different organisms match very well with each other and known three-dimensional structures of Nbs. Furthermore, phylogenetic tree reconstruction indicates that NPs and Nbs group in distinct clades. These data indicate that 10-stranded β-barrel Nbs constitute a new ubiquitous heme protein family spanning from bacteria to Homo sapiens. © 2016 IUBMB Life, 68(6):423-428, 2016. PMID:27080126

  16. Design, Manufacture, and Operation of a Core Barrel for the Iceland Deep Drilling Project (IDDP)

    NASA Astrophysics Data System (ADS)

    Skinner, A. C.; Bowers, P.; Þórhallsson, S.; Ómar Friðleifsson, G.; Guðmundsson, H.

    2010-09-01

    The science program of the Iceland Deep Drilling Project (IDDP) requires as much core as possible in the transition zone to supercritical and inside the supercritical zone (>374°C), in the depth interval 2400-4500 m. The spot coring system selected has a 7 1/4" (184.15 mm) OD at 10 m length and collects a 4" (101.6 mm) diameter core using an 8 1/2" (215.9 mm) OD core bit. It incorporates design characteristics, materials, clearances and bearings compatible with operation of the core barrel at temperatures as high as 600°C. Special attention was given to the volume of flushing which could be applied to the core barrel and through the bit while running in and out of the borehole and while coring. In November 2008 a successful spot coring test using the new core barrel was performed at 2800 m depth in the production well RN-17 B at Reykjanes, Iceland, where the formation temperature is 322°C. A 9.3-m hydrothermally altered hyaloclastite breccia was cored with 100% core recovery, in spite of it being highly fractured. A core tube data logger was also designed and placed inside the inner barrel to monitor the effectiveness of cooling. The temperature could be maintained at 100°C while coring, but it reached 170°C for a very short period while tripping in. The effective cooling is attributed to the high flush design and a top drive being employed, which allows circulation while tripping in or out, except for the very short time when a new drill pipe connection is being made. doi:10.2204/iodp.sd.10.05.2010

  17. Folding of β-barrel membrane proteins in lipid bilayers - Unassisted and assisted folding and insertion.

    PubMed

    Kleinschmidt, Jörg H

    2015-09-01

    In cells, β-barrel membrane proteins are transported in unfolded form to an outer membrane into which they fold and insert. Model systems have been established to investigate the mechanisms of insertion and folding of these versatile proteins into detergent micelles, lipid bilayers and even synthetic amphipathic polymers. In these experiments, insertion into lipid membranes is initiated from unfolded forms that do not display residual β-sheet secondary structure. These studies therefore have allowed the investigation of membrane protein folding and insertion in great detail. Folding of β-barrel membrane proteins into lipid bilayers has been monitored from unfolded forms by dilution of chaotropic denaturants that keep the protein unfolded as well as from unfolded forms present in complexes with molecular chaperones from cells. This review is aimed to provide an overview of the principles and mechanisms observed for the folding of β-barrel transmembrane proteins into lipid bilayers, the importance of lipid-protein interactions and the function of molecular chaperones and folding assistants. This article is part of a Special Issue entitled: Lipid-protein interactions. PMID:25983306

  18. Spatiotemporal distribution of proteoglycans in the developing rat's barrel field and the effects of early deafferentation.

    PubMed

    Bahia, Carlomagno Pacheco; Houzel, Jean-Christophe; Picanço-Diniz, Cristovam Wanderley; Pereira, Antonio

    2008-09-10

    The isolectin Vicia villosa B(4) (VV) selectively recognizes N-acetyl-galactosamine-terminal glycoconjugates that form perineuronal nets (PNNs) around a subset of neurons in the cerebral cortex. PNNs are thought to participate in the guidance of incoming thalamic axons and in the posterior stabilization and maintenance of synaptic contacts. Here we examine the spatial and temporal distribution of biotinylated VV in tangential sections through layer IV of the posteromedial barrel subfield in the primary somatosensory cortex (PMBSF) of rats ranging from postnatal day (P)3 to P60, which underwent unilateral deafferentation of whiskers at birth. In the afferented hemisphere, labeling first appears at P5, with a diffuse distribution, probably associated with neuropil, inside PMBSF barrels. VV distribution remains diffuse during the following week, and declines around P17. From P24 onward, however, proteoglycans form PNNs around cell bodies preferentially localized in septal regions of the PMBSF. In the contralateral, deafferented PMBSF the diffuse labeling also appears on P5, but first develops into elongated, homogeneous stripes, which disappear after P24, leaving only scattered cell bodies along layer IV. Our results indicate that proteoglycans appear simultaneous to barrel formation in the developing rat while segregation of PNNs to septal cells might be driven by afferent activity. PMID:18615535

  19. Amyloid β-Protein C-Terminal Fragments: Formation of Cylindrins and β-Barrels.

    PubMed

    Do, Thanh D; LaPointe, Nichole E; Nelson, Rebecca; Krotee, Pascal; Hayden, Eric Y; Ulrich, Brittany; Quan, Sarah; Feinstein, Stuart C; Teplow, David B; Eisenberg, David; Shea, Joan-Emma; Bowers, Michael T

    2016-01-20

    In order to evaluate potential therapeutic targets for treatment of amyloidoses such as Alzheimer's disease (AD), it is essential to determine the structures of toxic amyloid oligomers. However, for the amyloid β-protein peptide (Aβ), thought to be the seminal neuropathogenetic agent in AD, its fast aggregation kinetics and the rapid equilibrium dynamics among oligomers of different size pose significant experimental challenges. Here we use ion-mobility mass spectrometry, in combination with electron microscopy, atomic force microscopy, and computational modeling, to test the hypothesis that Aβ peptides can form oligomeric structures resembling cylindrins and β-barrels. These structures are hypothesized to cause neuronal injury and death through perturbation of plasma membrane integrity. We show that hexamers of C-terminal Aβ fragments, including Aβ(24-34), Aβ(25-35) and Aβ(26-36), have collision cross sections similar to those of cylindrins. We also show that linking two identical fragments head-to-tail using diglycine increases the proportion of cylindrin-sized oligomers. In addition, we find that larger oligomers of these fragments may adopt β-barrel structures and that β-barrels can be formed by folding an out-of-register β-sheet, a common type of structure found in amyloid proteins. PMID:26700445

  20. Plasticity-Related Gene 1 Affects Mouse Barrel Cortex Function via Strengthening of Glutamatergic Thalamocortical Transmission.

    PubMed

    Unichenko, Petr; Kirischuk, Sergei; Yang, Jenq-Wei; Baumgart, Jan; Roskoden, Thomas; Schneider, Patrick; Sommer, Angela; Horta, Guilherme; Radyushkin, Konstantin; Nitsch, Robert; Vogt, Johannes; Luhmann, Heiko J

    2016-07-01

    Plasticity-related gene-1 (PRG-1) is a brain-specific protein that modulates glutamatergic synaptic transmission. Here we investigated the functional role of PRG-1 in adolescent and adult mouse barrel cortex both in vitro and in vivo. Compared with wild-type (WT) animals, PRG-1-deficient (KO) mice showed specific behavioral deficits in tests assessing sensorimotor integration and whisker-based sensory discrimination as shown in the beam balance/walking test and sandpaper tactile discrimination test, respectively. At P25-31, spontaneous network activity in the barrel cortex in vivo was higher in KO mice compared with WT littermates, but not at P16-19. At P16-19, sensory evoked cortical responses in vivo elicited by single whisker stimulation were comparable in KO and WT mice. In contrast, at P25-31 evoked responses were smaller in amplitude and longer in duration in WT animals, whereas KO mice revealed no such developmental changes. In thalamocortical slices from KO mice, spontaneous activity was increased already at P16-19, and glutamatergic thalamocortical inputs to Layer 4 spiny stellate neurons were potentiated. We conclude that genetic ablation of PRG-1 modulates already at P16-19 spontaneous and evoked excitability of the barrel cortex, including enhancement of thalamocortical glutamatergic inputs to Layer 4, which distorts sensory processing in adulthood. PMID:26980613

  1. Similarity in Shape Dictates Signature Intrinsic Dynamics Despite No Functional Conservation in TIM Barrel Enzymes

    PubMed Central

    Tiwari, Sandhya P.; Reuter, Nathalie

    2016-01-01

    The conservation of the intrinsic dynamics of proteins emerges as we attempt to understand the relationship between sequence, structure and functional conservation. We characterise the conservation of such dynamics in a case where the structure is conserved but function differs greatly. The triosephosphate isomerase barrel fold (TBF), renowned for its 8 β-strand-α-helix repeats that close to form a barrel, is one of the most diverse and abundant folds found in known protein structures. Proteins with this fold have diverse enzymatic functions spanning five of six Enzyme Commission classes, and we have picked five different superfamily candidates for our analysis using elastic network models. We find that the overall shape is a large determinant in the similarity of the intrinsic dynamics, regardless of function. In particular, the β-barrel core is highly rigid, while the α-helices that flank the β-strands have greater relative mobility, allowing for the many possibilities for placement of catalytic residues. We find that these elements correlate with each other via the loops that link them, as opposed to being directly correlated. We are also able to analyse the types of motions encoded by the normal mode vectors of the α-helices. We suggest that the global conservation of the intrinsic dynamics in the TBF contributes greatly to its success as an enzymatic scaffold both through evolution and enzyme design. PMID:27015412

  2. Orofacial Neuropathic Pain Leads to a Hyporesponsive Barrel Cortex with Enhanced Structural Synaptic Plasticity

    PubMed Central

    Thibault, Karine; Rivière, Sébastien; Lenkei, Zsolt

    2016-01-01

    Chronic pain is a long-lasting debilitating condition that is particularly difficult to treat due to the lack of identified underlying mechanisms. Although several key contributing processes have been described at the level of the spinal cord, very few studies have investigated the supraspinal mechanisms underlying chronic pain. Using a combination of approaches (cortical intrinsic imaging, immunohistochemical and behavioural analysis), our study aimed to decipher the nature of functional and structural changes in a mouse model of orofacial neuropathic pain, focusing on cortical areas involved in various pain components. Our results show that chronic neuropathic orofacial pain is associated with decreased haemodynamic responsiveness to whisker stimulation in the barrel field cortex. This reduced functional activation is likely due to the increased basal neuronal activity (measured indirectly using cFos and phospho-ERK immunoreactivity) observed in several cortical areas, including the contralateral barrel field, motor and cingulate cortices. In the same animals, immunohistochemical analysis of markers for active pre- or postsynaptic elements (Piccolo and phospho-Cofilin, respectively) revealed an increased immunofluorescence in deep cortical layers of the contralateral barrel field, motor and cingulate cortices. These results suggest that long-lasting orofacial neuropathic pain is associated with exacerbated neuronal activity and synaptic plasticity at the cortical level. PMID:27548330

  3. Destiny of a drop on a fiber: from barrel to clamshell and back

    NASA Astrophysics Data System (ADS)

    Eral, Burak; de Ruiter, J.; de Ruiter, R.; Oh, J. M.; Semprebon, C.; Brinkman, M.; Mugele, F.

    2011-11-01

    Drops on cylindrical fibers are a familiar sight, for instance in the form of dew drops on spider webs. They can exist in two competing morphologies, a cylindrically symmetric barrel state completely engulfing the fiber and an asymmetric clamshell state, in which the drop sits on the side of the fiber. Despite their omnipresence and their practical relevance the physical mechanisms governing the stability of the two morphologies remained elusive. Using electrowetting-functionalized fibers we determined of the stability limits of both morphologies as a function of the two relevant control parameters, the contact angle and the liquid volume. While clamshells are found to prevail for large contact angles and small volumes, and barrels prevail for small angles and large volumes, there is also a wide range of intermediate parameter values, for which both morphologies are mechanically stable. Mapping out the energy landscape of the system by numerical minimization of the free energy we find that the barrel state is easily deformed by non-axisymmetric perturbations. From a general perspective, the demonstration of electrowetting-based reversible switching of liquid morphologies on fibers opens up opportunities for designing functional textiles and porous materials. We thank the Chemical Sciences division of the Netherlands Organization for Scientific Research (NWO-CW) for financial support.

  4. Plasticity-Related Gene 1 Affects Mouse Barrel Cortex Function via Strengthening of Glutamatergic Thalamocortical Transmission

    PubMed Central

    Unichenko, Petr; Kirischuk, Sergei; Yang, Jenq-Wei; Baumgart, Jan; Roskoden, Thomas; Schneider, Patrick; Sommer, Angela; Horta, Guilherme; Radyushkin, Konstantin; Nitsch, Robert; Vogt, Johannes; Luhmann, Heiko J.

    2016-01-01

    Plasticity-related gene-1 (PRG-1) is a brain-specific protein that modulates glutamatergic synaptic transmission. Here we investigated the functional role of PRG-1 in adolescent and adult mouse barrel cortex both in vitro and in vivo. Compared with wild-type (WT) animals, PRG-1-deficient (KO) mice showed specific behavioral deficits in tests assessing sensorimotor integration and whisker-based sensory discrimination as shown in the beam balance/walking test and sandpaper tactile discrimination test, respectively. At P25-31, spontaneous network activity in the barrel cortex in vivo was higher in KO mice compared with WT littermates, but not at P16-19. At P16-19, sensory evoked cortical responses in vivo elicited by single whisker stimulation were comparable in KO and WT mice. In contrast, at P25-31 evoked responses were smaller in amplitude and longer in duration in WT animals, whereas KO mice revealed no such developmental changes. In thalamocortical slices from KO mice, spontaneous activity was increased already at P16-19, and glutamatergic thalamocortical inputs to Layer 4 spiny stellate neurons were potentiated. We conclude that genetic ablation of PRG-1 modulates already at P16-19 spontaneous and evoked excitability of the barrel cortex, including enhancement of thalamocortical glutamatergic inputs to Layer 4, which distorts sensory processing in adulthood. PMID:26980613

  5. A Novel Mitosomal β-Barrel Outer Membrane Protein in Entamoeba

    PubMed Central

    Santos, Herbert J.; Imai, Kenichiro; Makiuchi, Takashi; Tomii, Kentaro; Horton, Paul; Nozawa, Akira; Ibrahim, Mohamed; Tozawa, Yuzuru; Nozaki, Tomoyoshi

    2015-01-01

    Entamoeba possesses a highly divergent mitochondrion-related organelle known as the mitosome. Here, we report the discovery of a novel protein in Entamoeba, which we name Mitosomal β-barrel Outer Membrane Protein of 30 kDa (MBOMP30). Initially identified through in silico analysis, we experimentally confirmed that MBOMP30 is indeed a β-barrel protein. Circular dichroism analysis showed MBOMP30 has a predominant β-sheet structure. Localization to Entamoeba histolytica mitosomes was observed through Percoll-gradient fractionation and immunofluorescence assay. Mitosomal membrane integration was demonstrated by carbonate fractionation, proteinase K digestion, and immunoelectron microscopy. Interestingly, the deletion of the putative β-signal, a sequence believed to guide β-barrel outer membrane protein (BOMP) assembly, did not affect membrane integration, but abolished the formation of a ~240 kDa complex. MBOMP30 represents only the seventh subclass of eukaryotic BOMPs discovered to date and lacks detectable homologs outside Entamoeba, suggesting that it may be unique to Entamoeba mitosomes. PMID:25711150

  6. Orofacial Neuropathic Pain Leads to a Hyporesponsive Barrel Cortex with Enhanced Structural Synaptic Plasticity.

    PubMed

    Thibault, Karine; Rivière, Sébastien; Lenkei, Zsolt; Férézou, Isabelle; Pezet, Sophie

    2016-01-01

    Chronic pain is a long-lasting debilitating condition that is particularly difficult to treat due to the lack of identified underlying mechanisms. Although several key contributing processes have been described at the level of the spinal cord, very few studies have investigated the supraspinal mechanisms underlying chronic pain. Using a combination of approaches (cortical intrinsic imaging, immunohistochemical and behavioural analysis), our study aimed to decipher the nature of functional and structural changes in a mouse model of orofacial neuropathic pain, focusing on cortical areas involved in various pain components. Our results show that chronic neuropathic orofacial pain is associated with decreased haemodynamic responsiveness to whisker stimulation in the barrel field cortex. This reduced functional activation is likely due to the increased basal neuronal activity (measured indirectly using cFos and phospho-ERK immunoreactivity) observed in several cortical areas, including the contralateral barrel field, motor and cingulate cortices. In the same animals, immunohistochemical analysis of markers for active pre- or postsynaptic elements (Piccolo and phospho-Cofilin, respectively) revealed an increased immunofluorescence in deep cortical layers of the contralateral barrel field, motor and cingulate cortices. These results suggest that long-lasting orofacial neuropathic pain is associated with exacerbated neuronal activity and synaptic plasticity at the cortical level. PMID:27548330

  7. ATLAS-2 Video News Release

    NASA Technical Reports Server (NTRS)

    1993-01-01

    This NASA Kennedy Space Center (KSC) video presents a Marshall Space Flight Center-Television (MSFC-TV) news release describing the objectives of the Atmospheric Laboratory for Applications in Science-2 (ATLAS-2), which is being flown on STS-56. Dr. Tim Miller (Mission Scientist), Dr. Marsha Torr (Mission Scientist), and Teresa Vanhooser (Mission Manager) explain that the ATLAS-2 mission is being launched to study earth atmospheric interactions with the sun in general and how manmade chemicals and pollution are contributing to ozone depletion in our atmosphere in particular. Seven instruments comprise the core payload. ATLAS-2 is an integral part of the Spacelab contribution to NASA's Mission to Planet Earth and characterizes the chemical and physical components of Earth's middle atmosphere and the solar energy injected in the atmosphere, studies that began on ATLAS-1.

  8. BioFuels Atlas (Presentation)

    SciTech Connect

    Moriarty, K.

    2011-02-01

    Presentation for biennial merit review of Biofuels Atlas, a first-pass visualization tool that allows users to explore the potential of biomass-to-biofuels conversions at various locations and scales.

  9. ATLAS OF SOURCE EMISSION PARTICLES

    EPA Science Inventory

    An atlas of various source emission particles characterized by electron optical techniques has been compiled for use by air pollution investigators. The particles studied were emitted by mobile, stationary, and natural sources. Sources included automobiles, manufacturing operatio...

  10. Tampa Bay environmental atlas

    SciTech Connect

    Kunneke, J.T.; Palik, T.F.

    1984-12-01

    Biological and water resource data for Tampa Bay were compiled and mapped at a scale of 1:24,000. This atlas consists of (1) composited information overlain on 18 biological and 20 water resource base maps and (2) an accompanying map narrative. Subjects mapped on the water resource maps are contours of the mean middepth specific conductivity which can be converted to salinity; bathymetry, sediments, tidal currents, the freshwater/saltwater interface, dredge spoil disposal sites; locations of industrial and municipal point source discharges, tide stations, and water quality sampling stations. The point source discharge locations show permitted capacity and the water quality sampling stations show 5-year averages for chlorophyll, conductivity, turbidity, temperature, and total nitrogen. The subjects shown on the biological resource maps are clam and oyster beds, shellfish harvest areas, colonial bird nesting sites, manatee habitat, seagrass beds and artificial reefs. Spawning seasons, nursery habitats, and adult habitats are identified for major fish species. The atlas will provide useful information for coastal planning and management in Tampa Bay.

  11. The ATLAS-1 mission

    NASA Technical Reports Server (NTRS)

    Torr, Marsha R.

    1994-01-01

    Atmospheric Laboratory for Applications and Science (ATLAS)-1 was launched on March 24, 1992, carrying an international payload of 14 investigations, and conducted a successful series of experiments and observations over the subsequent 9 days. The objectives included: measuring the solar irradiance at high precision; remote sensing of the composition of the stratosphere, mesosphere, and thermosphere using techniques for wavelengths from 300 A to 5 mm; and inducing auroras by means of 1.2 amp electron beams. A subset of these instruments will subsequently be flown in a series of shuttle missions at roughly 1-year intervals over an 11-year solar cycle. The frequent recalibration opportunities afforded by such a program allows the transfer of calibrations to longer duration orbiting observatories. The ATLAS-1 mission occurred at the same time as the Upper Atmosphere Research Satellite (UARS), TIROS-N, and ERB satellites were in operation, and correlative measurements were conducted with these. In all, the mission was most successful in achieving its objectives and a unique and important database was acquired, with many scientific firsts accomplished. This paper provides the mission overview for the series of papers that follow.

  12. Atlas Distributed Analysis Tools

    NASA Astrophysics Data System (ADS)

    de La Hoz, Santiago Gonzalez; Ruiz, Luis March; Liko, Dietrich

    2008-06-01

    The ATLAS production system has been successfully used to run production of simulation data at an unprecedented scale. Up to 10000 jobs were processed in one day. The experiences obtained operating the system on several grid flavours was essential to perform a user analysis using grid resources. First tests of the distributed analysis system were then performed. In the preparation phase data was registered in the LHC File Catalog (LFC) and replicated in external sites. For the main test, few resources were used. All these tests are only a first step towards the validation of the computing model. The ATLAS management computing board decided to integrate the collaboration efforts in distributed analysis in only one project, GANGA. The goal is to test the reconstruction and analysis software in a large scale Data production using Grid flavors in several sites. GANGA allows trivial switching between running test jobs on a local batch system and running large-scale analyses on the Grid; it provides job splitting and merging, and includes automated job monitoring and output retrieval.

  13. AIR AND ENERGY ENGINEERING RESEARCH LABORATORY (AEERL) PROCEDURES MANUAL: LEVEL 1 ENVIRONMENTAL ASSESSMENT TERRESTRIAL ECOLOGICAL TESTS

    EPA Science Inventory

    The manual provides detailed procedures for EPA/AEERL's Level 1 terrestrial bioassays. (Some test methods designated for AEERL's Level 1 environmental assessment biological testing program are sufficiently new that little or no published literature is available describing specifi...

  14. ATLAS discoveries of optical transients

    NASA Astrophysics Data System (ADS)

    Tonry, J.; Denneau, L.; Stalder, B.; Heinze, A.; Sherstyuk, A.; Rest, A.; Smith, K. W.; Smartt, S. J.

    2016-09-01

    We report the following transients found by the ATLAS survey (see Tonry et al. ATel #8680). ATLAS is a twin 0.5m telescope system on Haleakala and Mauna Loa. The first unit is operational on Haleakala is robotically surveying the sky. Two filters are used, cyan and orange (denoted c and o, all mags in AB system), more information is on http://www.fallingstar.com.

  15. ATLAS discoveries of optical transients

    NASA Astrophysics Data System (ADS)

    Tonry, J.; Denneau, L.; Stalder, B.; Heinze, A.; Sherstyuk, A.; Rest, A.; Smith, K. W.; Smartt, S. J.

    2016-06-01

    We report the following transients found by the ATLAS survey (see Tonry et al. ATel #8680). ATLAS is a twin 0.5m telescope system on Haleakala and Mauna Loa. The first unit is operational on Haleakala is robotically surveying the sky. Two filters are used, cyan and orange (denoted c and o, all mags in AB system), more information is on http://www.fallingstar.com.

  16. The ATLAS-1 Shuttle mission

    NASA Technical Reports Server (NTRS)

    Torr, Marsha R.; Sullivan, Kathryn D.

    1992-01-01

    The Atmospheric Laboratory for Applications and Science (ATLAS-1) encompasses instruments which will be useful in determining long-term solar variability as well as in forging links to the measurements obtained by other spacecraft for the perturbed middle and upper atmosphere. The simultaneous measurements that will be conducted by ATLAS-1 of stratospheric concentrations of ozone, chlorine monoxide and water vapor, at relatively high latitudes during the northern spring, will be especially timely.

  17. ATLAS discoveries of optical transients

    NASA Astrophysics Data System (ADS)

    Tonry, J.; Denneau, L.; Stalder, B.; Heinze, A.; Sherstyuk, A.; Rest, A.; Smith, K. W.; Smartt, S. J.

    2016-03-01

    We report the following transients found by the ATLAS survey (see Tonry et al. ATel #8680). ATLAS is a twin 0.5m telescope system on Haleakala and Mauna Loa. The first unit is operational on Haleakala is robotically surveying the sky. Two filters are used, cyan and orange (denoted c and o, all mags in AB system), more information is on http://www.fallingstar.com.

  18. ATLAS discoveries of optical transients

    NASA Astrophysics Data System (ADS)

    Tonry, J.; Denneau, L.; Stalder, B.; Heinze, A.; Sherstyuk, A.; Rest, A.; Smith, K. W.; Smartt, S. J.

    2016-08-01

    We report the following transients found by the ATLAS survey (see Tonry et al. ATel #8680). ATLAS is a twin 0.5m telescope system on Haleakala and Mauna Loa. The first unit is operational on Haleakala is robotically surveying the sky. Two filters are used, cyan and orange (denoted c and o, all mags in AB system), more information is on http://www.fallingstar.com.

  19. Methodology of Lithuanian climate atlas mapping

    NASA Astrophysics Data System (ADS)

    Valiukas, Donatas; Galvonaitė, Audronė; Česnulevičius, Algimantas

    2015-06-01

    Climate atlases summarize large sets of quantitative and qualitative data and are results of complex analytical cartographic work. These special geographical publications summarize long term meteorological observations, provide maps and figures which characterise different climate elements. Visual information is supplemented with explanatory texts. A lot of information on short and long term changes of climate elements were provided in published Lithuanian atlases (Atlas of Lithuanian SDR, 1981; Climate Atlas of Lithuania, 2013), as well as in prepared but unpublished Lithuanian Atlas (1989) and in upcoming new national atlas publications (National Atlas of Lithuania. 1st part, 2014). Climate atlases has to be constantly updated to be relevant and to describe current climate conditions. Comprehensive indicators of Lithuanian climate are provided in different cartographic publications. Different time periods, various data sets and diverse cartographic data analysis tools and visualisation methods were used in these different publications.

  20. ATLAS Cloud R&D

    NASA Astrophysics Data System (ADS)

    Panitkin, Sergey; Barreiro Megino, Fernando; Caballero Bejar, Jose; Benjamin, Doug; Di Girolamo, Alessandro; Gable, Ian; Hendrix, Val; Hover, John; Kucharczyk, Katarzyna; Medrano Llamas, Ramon; Love, Peter; Ohman, Henrik; Paterson, Michael; Sobie, Randall; Taylor, Ryan; Walker, Rodney; Zaytsev, Alexander; Atlas Collaboration

    2014-06-01

    The computing model of the ATLAS experiment was designed around the concept of grid computing and, since the start of data taking, this model has proven very successful. However, new cloud computing technologies bring attractive features to improve the operations and elasticity of scientific distributed computing. ATLAS sees grid and cloud computing as complementary technologies that will coexist at different levels of resource abstraction, and two years ago created an R&D working group to investigate the different integration scenarios. The ATLAS Cloud Computing R&D has been able to demonstrate the feasibility of offloading work from grid to cloud sites and, as of today, is able to integrate transparently various cloud resources into the PanDA workload management system. The ATLAS Cloud Computing R&D is operating various PanDA queues on private and public resources and has provided several hundred thousand CPU days to the experiment. As a result, the ATLAS Cloud Computing R&D group has gained a significant insight into the cloud computing landscape and has identified points that still need to be addressed in order to fully utilize this technology. This contribution will explain the cloud integration models that are being evaluated and will discuss ATLAS' learning during the collaboration with leading commercial and academic cloud providers.

  1. Telemetry system for the transmission of data from projectiles during the acceleration phase in the gun barrel

    NASA Astrophysics Data System (ADS)

    Wegner, V.

    1984-05-01

    A ballistic telemetry system reliable for accelerations up 100,00 g was developed. It consist of industrially produced thick layer 10 mm x 10 mm components which can be assembled to a telemetry system according to the unit box principle depending on user requirements. The electronic circuits are fixed in the gun barrel with epoxy resin. The short time phenomena and the limited space require analog data transmission. The 30 mm barrels used for interior ballistics tests and the block diagram of the measuring system are described. The results of the axial acceleration measurements show very clearly the effect of the injection resistance at the beginning of the projectile motion, and by integration provide the temporal evolution of the projectile velocity in the barrel. The measurements of the transverse acceleration clearly show the effect of the barrel curvature and the gravitational force. A wire and an optoelectronic transmission system were developed.

  2. EMISSIONS OF POLYCHLORINATED DIBENZO-P-DIOXINS AND POLYCHLORINATED DIBENZOFURANS FROM THE OPEN BURNING OF HOUSEHOLD WASTE IN BARRELS

    EPA Science Inventory

    Backyard burning of household waste in barrels is a common waste disposal practice for which pollutant emissions have not been well characterized. This study measured the emissions of several pollutants, including polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofura...

  3. The N-terminus of VDAC: Structure, mutational analysis, and a potential role in regulating barrel shape.

    PubMed

    Shuvo, Sabbir R; Ferens, Fraser G; Court, Deborah A

    2016-06-01

    A novel feature of the voltage-dependent anion channel (VDAC, mitochondrial porin), is the barrel, comprising an odd number of β-strands and closed by parallel strands. Recent research has focused on the N-terminal segment, which in the available structures, resides in the lumen and is not part of the barrel. In this review, the structural data obtained from vertebrate VDAC are integrated with those from VDAC in artificial bilayers, emphasizing the array of native and tagged versions of VDAC used. The data are discussed with respect to a recent gating model (Zachariae et al. (2012) Structure 20:1-10), in which the N-terminus acts not as a gate on a stable barrel, but rather stabilizes the barrel, preventing its shift into a partially collapsed, low-conductance, closed state. Additionally, the role of the N-terminus in VDAC oligomerization, apoptosis through interactions with hexokinase and its interaction with ATP are discussed briefly. PMID:26997586

  4. L1 track triggers for ATLAS in the HL-LHC

    DOE PAGESBeta

    Lipeles, E.

    2012-01-01

    The HL-LHC, the planned high luminosity upgrade for the LHC, will increase the collision rate in the ATLAS detector approximately a factor of 5 beyond the luminosity for which the detectors were designed, while also increasing the number of pile-up collisions in each event by a similar factor. This means that the level-1 trigger must achieve a higher rejection factor in a more difficult environment. This presentation discusses the challenges that arise in this environment and strategies being considered by ATLAS to include information from the tracking systems in the level-1 decision. The main challenges involve reducing the data volumemore » exported from the tracking system for which two options are under consideration: a region of interest based system and an intelligent sensor method which filters on hits likely to come from higher transverse momentum tracks.« less

  5. L1 track triggers for ATLAS in the HL-LHC

    SciTech Connect

    Lipeles, E.

    2012-01-01

    The HL-LHC, the planned high luminosity upgrade for the LHC, will increase the collision rate in the ATLAS detector approximately a factor of 5 beyond the luminosity for which the detectors were designed, while also increasing the number of pile-up collisions in each event by a similar factor. This means that the level-1 trigger must achieve a higher rejection factor in a more difficult environment. This presentation discusses the challenges that arise in this environment and strategies being considered by ATLAS to include information from the tracking systems in the level-1 decision. The main challenges involve reducing the data volume exported from the tracking system for which two options are under consideration: a region of interest based system and an intelligent sensor method which filters on hits likely to come from higher transverse momentum tracks.

  6. Neonatal Atlas Construction Using Sparse Representation

    PubMed Central

    Shi, Feng; Wang, Li; Wu, Guorong; Li, Gang; Gilmore, John H.; Lin, Weili; Shen, Dinggang

    2014-01-01

    Atlas construction generally includes first an image registration step to normalize all images into a common space and then an atlas building step to fuse the information from all the aligned images. Although numerous atlas construction studies have been performed to improve the accuracy of the image registration step, unweighted or simply weighted average is often used in the atlas building step. In this article, we propose a novel patch-based sparse representation method for atlas construction after all images have been registered into the common space. By taking advantage of local sparse representation, more anatomical details can be recovered in the built atlas. To make the anatomical structures spatially smooth in the atlas, the anatomical feature constraints on group structure of representations and also the overlapping of neighboring patches are imposed to ensure the anatomical consistency between neighboring patches. The proposed method has been applied to 73 neonatal MR images with poor spatial resolution and low tissue contrast, for constructing a neonatal brain atlas with sharp anatomical details. Experimental results demonstrate that the proposed method can significantly enhance the quality of the constructed atlas by discovering more anatomical details especially in the highly convoluted cortical regions. The resulting atlas demonstrates superior performance of our atlas when applied to spatially normalizing three different neonatal datasets, compared with other start-of-the-art neonatal brain atlases. PMID:24638883

  7. ATLAS Series of Shuttle Missions. Volume 23

    NASA Technical Reports Server (NTRS)

    1996-01-01

    This technical paper contains selected papers from Geophysical Research Letters (Volume 23, Number 17) on ATLAS series of shuttle missions. The ATLAS space shuttle missions were conducted in March 1992, April 1993, and November 1994. This paper discusses solar irradiance, middle atmospheric temperatures, and trace gas concentrations measurements made by the ATLAS payload and companion instruments.

  8. Shifts in Developmental Timing, and Not Increased Levels of Experience-Dependent Neuronal Activity, Promote Barrel Expansion in the Primary Somatosensory Cortex of Rats Enucleated at Birth

    PubMed Central

    Fetter-Pruneda, Ingrid; Ibarrarán-Viniegra, Ana Sofía; Martínez-Martínez, Eduardo; Sandoval-Velasco, Marcela; Uribe-Figueroa, Laura; Padilla-Cortés, Patricia; Mercado-Célis, Gabriela; Gutiérrez-Ospina, Gabriel

    2013-01-01

    Birth-enucleated rodents display enlarged representations of whiskers (i.e., barrels of the posteromedial subfield) in the primary somatosensory cortex. Although the historical view maintains that barrel expansion is due to incremental increases in neuronal activity along the trigeminal pathway during postnatal development, recent evidence obtained in experimental models of intramodal plasticity challenges this view. Here, we re-evaluate the role of experience-dependent neuronal activity on barrel expansion in birth-enucleated rats by combining various anatomical methods and sensory deprivation paradigms. We show that barrels in birth-enucleated rats were already enlarged by the end of the first week of life and had levels of metabolic activity comparable to those in control rats at different ages. Dewhiskering after the postnatal period of barrel formation did not prevent barrel expansion in adult, birth-enucleated rats. Further, dark rearing and enucleation after barrel formation did not lead to expanded barrels in adult brains. Because incremental increases of somatosensory experience did not promote barrel expansion in birth-enucleated rats, we explored whether shifts of the developmental timing could better explain barrel expansion during the first week of life. Accordingly, birth-enucleated rats show earlier formation of barrels, accelerated growth of somatosensory thalamocortical afferents, and an earlier H4 deacetylation. Interestingly, when H4 deacetylation was prevented with a histone deacetylases inhibitor (valproic acid), barrel specification timing returned to normal and barrel expansion did not occur. Thus, we provide evidence supporting that shifts in developmental timing modulated through epigenetic mechanisms, and not increased levels of experience dependent neuronal activity, promote barrel expansion in the primary somatosensory cortex of rats enucleated at birth. PMID:23372796

  9. A barrel-related interneuron in layer 4 of rat somatosensory cortex with a high intrabarrel connectivity.

    PubMed

    Koelbl, Christian; Helmstaedter, Moritz; Lübke, Joachim; Feldmeyer, Dirk

    2015-03-01

    Synaptic connections between identified fast-spiking (FS), parvalbumin (PV)-positive interneurons, and excitatory spiny neurons in layer 4 (L4) of the barrel cortex were investigated using patch-clamp recordings and simultaneous biocytin fillings. Three distinct clusters of FS L4 interneurons were identified based on their axonal morphology relative to the barrel column suggesting that these neurons do not constitute a homogeneous interneuron population. One L4 FS interneuron type had an axonal domain strictly confined to a L4 barrel and was therefore named "barrel-confined inhibitory interneuron" (BIn). BIns established reliable inhibitory synaptic connections with L4 spiny neurons at a high connectivity rate of 67%, of which 69% were reciprocal. Unitary IPSPs at these connections had a mean amplitude of 0.9 ± 0.8 mV with little amplitude variation and weak short-term synaptic depression. We found on average 3.7 ± 1.3 putative inhibitory synaptic contacts that were not restricted to perisomatic areas. In conclusion, we characterized a novel type of barrel cortex interneuron in the major thalamo-recipient layer 4 forming dense synaptic networks with L4 spiny neurons. These networks constitute an efficient and powerful inhibitory feedback system, which may serve to rapidly reset the barrel microcircuitry following sensory activation. PMID:24076498

  10. Atlas of Nuclear Isomers

    NASA Astrophysics Data System (ADS)

    Jain, Ashok Kumar; Maheshwari, Bhoomika; Garg, Swati; Patial, Monika; Singh, Balraj

    2015-09-01

    We present an atlas of nuclear isomers containing the experimental data for the isomers with a half-life ≥ 10 ns together with their various properties such as excitation-energy, half-life, decay mode(s), spin-parity, energies and multipolarities of emitted gamma transitions, etc. The ENSDF database complemented by the XUNDL database has been extensively used in extracting the relevant data. Recent literature from primary nuclear physics journals, and the NSR bibliographic database have been searched to ensure that the compiled data Table is as complete and current as possible. The data from NUBASE-12 have also been checked for completeness, but as far as possible original references have been cited. Many interesting systematic features of nuclear isomers emerge, some of them new; these are discussed and presented in various graphs and figures. The cutoff date for the extraction of data from the literature is August 15, 2015.

  11. Atlas of Nuclear Isomers

    SciTech Connect

    Jain, Ashok Kumar; Maheshwari, Bhoomika; Garg, Swati; Patial, Monika; Singh, Balraj

    2015-09-15

    We present an atlas of nuclear isomers containing the experimental data for the isomers with a half-life ≥ 10 ns together with their various properties such as excitation-energy, half-life, decay mode(s), spin-parity, energies and multipolarities of emitted gamma transitions, etc. The ENSDF database complemented by the XUNDL database has been extensively used in extracting the relevant data. Recent literature from primary nuclear physics journals, and the NSR bibliographic database have been searched to ensure that the compiled data Table is as complete and current as possible. The data from NUBASE-12 have also been checked for completeness, but as far as possible original references have been cited. Many interesting systematic features of nuclear isomers emerge, some of them new; these are discussed and presented in various graphs and figures. The cutoff date for the extraction of data from the literature is August 15, 2015.

  12. Atlas of fatigue curves

    SciTech Connect

    Boyer, H.E.

    1986-01-01

    This Atlas was developed to serve engineers who are looking for fatigue data on a particular metal or alloy. Having these curves compiled in a single book will also facilitate the computerization of the involved data. It is pointed out that plans are under way to make the data in this book available in ASCII files for analysis by computer programs. S-N curves which typify effects of major variables are considered along with low-carbon steels, medium-carbon steels, alloy steels, HSLA steels, high-strength alloy steels, heat-resisting steels, stainless steels, maraging steels, cast irons, and heat-resisting alloys. Attention is also given to aluminum alloys, copper alloys, magnesium alloys, molybdenum, tin alloys, titanium and titanium alloys, zirconium, steel castings, closed-die forgings, powder metallurgy parts, composites, effects of surface treatments, and test results for component parts.

  13. Consumer Energy Atlas

    SciTech Connect

    Not Available

    1980-06-01

    This first edition of the Atlas provides, in reference form, a central source of information to consumers on key contacts concerned with energy in the US. Energy consumers need information appropriate to local climates and characteristics - best provided by state and local governments. The Department of Energy recognizes the authority of state and local governments to manage energy programs on their own. Therefore, emphasis has been given to government organizations on both the national and state level that influence, formulate, or administer policies affecting energy production, distribution, and use, or that provide information of interest to consumers and non-specialists. In addition, hundreds of non-government energy-related membership organizations, industry trade associations, and energy publications are included.

  14. Anti-Atlas Mountains, Morocco

    NASA Technical Reports Server (NTRS)

    2002-01-01

    The Anti-Atlas Mountains of northern Africa and the nearby Atlas mountains were created by the prolonged collision of the African and Eurasian tectonic plates, beginning about 80 million years ago. Massive sandstone and limestone layers have been crumpled and uplifted more than 4,000 meters in the High Atlas and to lower elevations in the Anti-Atlas. Between more continuous major fold structures, such as the Jbel Ouarkziz in the southwestern Anti-Atlas, tighter secondary folds (arrow) have developed. Earlier, the supercontinent of Pangea rifted apart to form precursors to the Mediterranean and the Atlantic Ocean (Beauchamp and others, 1996). In those seas sands, clays, limey sediments, and evaporite layers (gypsum, rock salt) were deposited. Later, during the mountain-building plate collision, the gypsum layers flowed under the pressure and provided a slippery surface on which overlying rigid rocks could glide (Burkhard, 2001). The broad, open style of folds seen in this view is common where evaporites are involved in the deformation. Other examples can be found in the Southern Zagros of Iran and the Sierra Madre Oriental of Mexico. Information Sources: Beauchamp, W., Barazangi, M., Demnati, A., and El Alji, M., 1996, Intracontinental rifting and inversion: Missour Basin and Atlas Mountains, Morocco: Tulsa, American Association of Petroleum Geologists Bulletin, v. 80, No. 9, p. 1459-1482. Burkhard, Martin, 2001, Tectonics of the Anti-Atlas of Morocco -- Thin-skin/thick-skin relationships in an atypical foreland fold belt. University of Neuchatel, Switzerland: http://www-geol.unine.ch/Structural/Antiatlas.html (accessed 1/29/02). STS108-711-25 was taken in December, 2001 by the crew of Space Shuttle mission 108 using a Hasselblad camera with 250-mm lens. The image is provided by the Earth Sciences and Image Analysis Laboratory at Johnson Space Center. Additional images taken by astronauts and cosmonauts can be viewed at the NASA-JSC Gateway to Astronaut Photography

  15. The cooling capabilities of C2F6/C3F8 saturated fluorocarbon blends for the ATLAS silicon tracker

    NASA Astrophysics Data System (ADS)

    Bates, R.; Battistin, M.; Berry, S.; Bitadze, A.; Bonneau, P.; Bousson, N.; Boyd, G.; Botelho-Direito, J.; Crespo-Lopez, O.; DiGirolamo, B.; Doubek, M.; Giugni, D.; Hallewell, G.; Lombard, D.; Katunin, S.; McMahon, S.; Nagai, K.; Robinson, D.; Rossi, C.; Rozanov, A.; Vacek, V.; Zwalinski, L.

    2015-03-01

    We investigate and address the performance limitations of the ATLAS silicon tracker fluorocarbon evaporative cooling system operation in the cooling circuits of the barrel silicon microstrip (SCT) sub-detector. In these circuits the minimum achievable evaporation temperatures with C3F8 were higher than the original specification, and were thought to allow an insufficient safety margin against thermal runaway in detector modules subject to a radiation dose initially foreseen for 10 years operation at LHC. We have investigated the cooling capabilities of blends of C3F8 with molar admixtures of up to 25% C2F6, since the addition of the more volatile C2F6 component was expected to allow a lower evaporation temperature for the same evaporation pressure.A custom built recirculator allowed the in-situ preparation of C2F6/C3F8 blends. These were circulated through a representative mechanical and thermal setup reproducing an as-installed ATLAS SCT barrel tracker cooling circuit. Blend molar compositions were verified to a precision of 3.10-3 in a custom ultrasonic instrument.Thermal measurements in a range of C2F6/C3F8 blends were compared with measurements in pure C3F8. These indicated that a blend with 25% C2F6 would allow a reduction in evaporation temperature of around 9oC to below -15oC, even at the highest module power dissipations envisioned after 10 years operation at LHC. Such a reduction would allow more than a factor two in safety margin against temperature dependant leakage power induced thermal runaway.Furthermore, a blend containing up to 25% C2F6 could be circulated without changes to the on-detector elements of the existing ATLAS inner detector evaporative cooling system.

  16. TRTViewer: The ATLAS TRT detector monitoring and diagnosticstool

    NASA Astrophysics Data System (ADS)

    Smirnov, S. Yu.; Atlas Collaboration

    2013-04-01

    The transition radiation tracker (TRT) is the outermost of the three sub-systems of the ATLAS inner detector at the Large Hadron Collider (LHC) at CERN. It is designed to combine the drift tube tracker with the transition radiation detector, providing an important contribution to the charged particles precise momentum measurement and particle (mainly electron) identification. The TRT consists of a barrel section at small pseudorapidity (η) and two separate end-cap partitions at large η. The detector performance and its operational conditions were permanently monitored during all commissioning and data-taking stages using various software tools, one of which - TRTViewer - is described in the present paper. The TRTViewer is the dedicated program for monitoring the TRT raw data quality and detector performance at different hardware levels: individual straws, readout chips and electronic boards. The data analysis results can be presented on the event-by-event basis or in the form of color maps representing the operation parameters (efficiencies, timing, occupancy, etc.) according to the real geometrical position of the detector hardware elements. The paper describes the TRTViewer software package as the event displaying tool, raw data processor and histogram and operation parameters presenter, which works with the different sources of input information: raw data files, online monitoring histograms, offline analysis histograms and TRT DAQ Configuration database. The package proved to be one of the main instruments for the fast and effective TRT diagnostics during debugging and operation periods.

  17. Episodic barrel rotations induced by intrastriatal injection of quinolinic acid in rats. Inhibition by anticonvulsants.

    PubMed

    Marrannes, R; Wauquier, A

    1988-09-01

    Unilateral intrastriatal injection of quinolinic acid (2,3 pyridine dicarboxylate; QUIN) in the rat produces episodic barrel rotations and tonic-clonic forepaw movements, lasting for several hours. We investigated whether intraperitoneal posttreatment with anticonvulsants could abolish this phenomenon when it is already fully developed, and whether their potency ratio was similar in models of epilepsy. All 8 tested antiepileptics, namely carbamazepine, clonazepam, diazepam, diphenylhydantoin, ethosuximide, flunarizine, phenobarbital and sodium valproate decreased this behaviour in a dose-dependent way. Six other drugs with anticonvulsant properties were also effective: DL-2-amino-7-phosphonoheptanoic acid, desipramine, etomidate, ketamine, meprobamate and sabeluzole. The ED50-values for halving the frequency of the episodes of barrel rotation correlated well with published ED50-values for inhibition of tonic hindpaw extension in the maximal metrazol seizure test (rs = .95, p less than 0.001) and with the ED50-values for halving the duration of the forepaw clonus in the rat-kindling model (rs = .93, p less than 0.001). This quinolinic acid test allows visualization of the onset of action of anticonvulsants, with each animal as its own control. In order to assess whether this test is also sensitive to drugs influencing the symptoms of Huntington's disease, the effect of the dopamine antagonists haloperidol and pimozide, the acetylcholinesterase inhibitor physostigmine and the anticholinergics atropine and dexetimide were investigated as well. The experiments suggested that the barrel rotations and clonic forepaw movements, only 3-6 hours after intrastriatal injection of QUIN respond to anticonvulsants, but are not specifically sensitive to drugs used in the symptomatic treatment of Huntington's disease. PMID:2978064

  18. The design and performance of a twenty barrel hydrogen pellet injector for Alcator C-Mod

    SciTech Connect

    Urbahn, J.A.

    1994-05-01

    A twenty barrel hydrogen pellet injector has been designed, built and tested both in the laboratory and on the Alcator C-Mod Tokamak at MIT. The injector functions by firing pellets of frozen hydrogen or deuterium deep into the plasma discharge for the purpose of fueling the plasma, modifying the density profile and increasing the global energy confinement time. The design goals of the injector are: (1) Operational flexibility, (2) High reliability, (3) Remote operation with minimal maintenance. These requirements have lead to a single stage, pipe gun design with twenty barrels. Pellets are formed by in- situ condensation of the fuel gas, thus avoiding moving parts at cryogenic temperatures. The injector is the first to dispense with the need for cryogenic fluids and instead uses a closed cycle refrigerator to cool the thermal system components. The twenty barrels of the injector produce pellets of four different size groups and allow for a high degree of flexibility in fueling experiments. Operation of the injector is under PLC control allowing for remote operation, interlocked safety features and automated pellet manufacturing. The injector has been extrusively tested and shown to produce pellets reliably with velocities up to 1400 m/sec. During the period from September to November of 1993, the injector was successfully used to fire pellets into over fifty plasma discharges. Experimental results include data on the pellet penetration into the plasma using an advanced pellet tracking diagnostic with improved time and spatial response. Data from the tracker indicates pellet penetrations were between 30 and 86 percent of the plasma minor radius.

  19. Measurement of the Radiation Field in Atlas with the Atlas-Mpx Detectors

    NASA Astrophysics Data System (ADS)

    Campbell, Michael; Heijne, Erik; Leroy, Claude; Martin, Jean-Pierre; Mornacchi, Giuseppe; Nessi, Marzio; Pospisil, Stanislav; Solc, Jaroslav; Soueid, Paul; Suk, Michal; Turecek, Daniel; Vykydal, Zdenek

    2012-08-01

    A network of 16 ATLAS-MPX (silicon pixelated) detectors has been installed by the ATLAS-MPX Collaboration at various positions within the ATLAS detector and its environment. The ATLAS-MPX detectors allow real-time measurements of spectral characteristics and composition of the radiation field inside and around the ATLAS detector during its operation. Results obtained with the ATLAS-MPX detectors are reported in this article. They include luminosity measurement obtained with van der Meer luminosity scans and measurement of induced radioactivity in between/after collision.

  20. National Atlas of the United States Maps

    USGS Publications Warehouse

    U.S. Geological Survey

    2001-01-01

    The 'National Atlas of the United States of America?', published by the U.S. Geological Survey (USGS) in 1970, is out of print, but many of its maps can be purchased separately. Maps that span facing pages in the atlas are printed on one sheet. Maps dated after 1970 and before 1997 are either revisions of original atlas maps or new maps published in the original atlas format. The USGS and its partners in government and industry began work on a new 'National Atlas' in 1997. Though most new atlas products are designed for the World Wide Web, we are continuing our tradition of printing high-quality maps of America. In 1998, the first completely redesigned maps of the 'National Atlas of the United States?' were published.

  1. Cassini Tour Atlas Automated Generation

    NASA Technical Reports Server (NTRS)

    Grazier, Kevin R.; Roumeliotis, Chris; Lange, Robert D.

    2011-01-01

    During the Cassini spacecraft s cruise phase and nominal mission, the Cassini Science Planning Team developed and maintained an online database of geometric and timing information called the Cassini Tour Atlas. The Tour Atlas consisted of several hundreds of megabytes of EVENTS mission planning software outputs, tables, plots, and images used by mission scientists for observation planning. Each time the nominal mission trajectory was altered or tweaked, a new Tour Atlas had to be regenerated manually. In the early phases of Cassini s Equinox Mission planning, an a priori estimate suggested that mission tour designers would develop approximately 30 candidate tours within a short period of time. So that Cassini scientists could properly analyze the science opportunities in each candidate tour quickly and thoroughly so that the optimal series of orbits for science return could be selected, a separate Tour Atlas was required for each trajectory. The task of manually generating the number of trajectory analyses in the allotted time would have been impossible, so the entire task was automated using code written in five different programming languages. This software automates the generation of the Cassini Tour Atlas database. It performs with one UNIX command what previously took a day or two of human labor.

  2. The ATLAS distributed analysis system

    NASA Astrophysics Data System (ADS)

    Legger, F.; Atlas Collaboration

    2014-06-01

    In the LHC operations era, analysis of the multi-petabyte ATLAS data sample by globally distributed physicists is a challenging task. To attain the required scale the ATLAS Computing Model was designed around the concept of Grid computing, realized in the Worldwide LHC Computing Grid (WLCG), the largest distributed computational resource existing in the sciences. The ATLAS experiment currently stores over 140 PB of data and runs about 140,000 concurrent jobs continuously at WLCG sites. During the first run of the LHC, the ATLAS Distributed Analysis (DA) service has operated stably and scaled as planned. More than 1600 users submitted jobs in 2012, with 2 million or more analysis jobs per week, peaking at about a million jobs per day. The system dynamically distributes popular data to expedite processing and maximally utilize resources. The reliability of the DA service is high and steadily improving; Grid sites are continually validated against a set of standard tests, and a dedicated team of expert shifters provides user support and communicates user problems to the sites. Both the user support techniques and the direct feedback of users have been effective in improving the success rate and user experience when utilizing the distributed computing environment. In this contribution a description of the main components, activities and achievements of ATLAS distributed analysis is given. Several future improvements being undertaken will be described.

  3. Compressibility and Heating Effects on Pressure Loss and Cooling of a Baffled Cylinder Barrel

    NASA Technical Reports Server (NTRS)

    Goldstein, Arthur W; Ellerbrock, Herman H , Jr

    1944-01-01

    Theoretical investigations have shown that, because air is compressible, the pressure-drop requirements for cooling an air-cooled engine will be much greater at high altitudes and high speeds than at sea level and low speeds. Tests were conducted by the NACA to obtain some experimental confirmation of the effect of air compressibility on cooling and pressure loss of a baffled cylinder barrel and to evaluate various methods of analysis. The results reported in the present paper are regarded as preliminary to tests on single-cylinder and multicylinder engines. Tests were conducted over a wide range of air flows and density altitudes.

  4. Design and operation of a wireline pressure core barrel. Technical report

    SciTech Connect

    Peterson, M.N.A.

    1984-03-01

    The Deep Sea Drilling Project Technical Report No. 16 discusses the design and operation of the Pressure Core Barrel Mod III (PCB-III), and the development leading to this third version of a tool with a history dating back to 1973. The chief reason for its development was to recover methane gas hydrates - compounds that exist only within a narrow range of temperature and pressure. Its most important features include the ability to recover 6.8 meters of core at pressures of up 5000 psi, and its compatibility with the standard DSDP wireline coring system.

  5. Subintimal Double-Barrel Restenting of an Occluded Primary Stented Superficial Femoral Artery

    SciTech Connect

    Duterloo, Dirk Lohle, Paul N.M.; Lampmann, Leo E.H.

    2007-06-15

    In-stent re-stenosis is a frequent complication of endovascular stents, especially in the superficial femoral artery (SFA). Endovascular re-intervention of in- or peri-stent occlusive disease consists of recanilization through the occluded stent. In our case report, we describe the endovascular treatment of a previously placed stent in the SFA. We unintentionally passed the affected stent subintimally, in a double barrel fashion next to the first stent. The procedure was without any complications and with a successful angiographic result. At one year follow-up the patient still has no complaints and the stent is still patent.

  6. Structural Plasticity within the Barrel Cortex during Initial Phases of Whisker-Dependent Learning

    PubMed Central

    O'Connor, Daniel H.; Fox, Kevin; Svoboda, Karel

    2014-01-01

    We report learning-related structural plasticity in layer 1 branches of pyramidal neurons in the barrel cortex, a known site of sensorimotor integration. In mice learning an active, whisker-dependent object localization task, layer 2/3 neurons showed enhanced spine growth during initial skill acquisition that both preceded and predicted expert performance. Preexisting spines were stabilized and new persistent spines were formed. These findings suggest rapid changes in connectivity between motor centers and sensory cortex guide subsequent sensorimotor learning. PMID:24760867

  7. Map transfer from the thalamus to the neocortex: inputs from the barrel field.

    PubMed

    Lokmane, Ludmilla; Garel, Sonia

    2014-11-01

    Sensory perception relies on the formation of stereotyped maps inside the brain. This feature is particularly well illustrated in the mammalian neocortex, which is subdivided into distinct cortical sensory areas that comprise topological maps, such as the somatosensory homunculus in humans or the barrel field of the large whiskers in rodents. How somatosensory maps are formed and relayed into the neocortex remain essential questions in developmental neuroscience. Here, we will present our current knowledge on whisker map transfer in the mouse model, with the goal of linking embryonic and postnatal studies into a comprehensive framework. PMID:25020201

  8. Correlations Decrease with Propagation of Spiking Activity in the Mouse Barrel Cortex

    PubMed Central

    Ranganathan, Gayathri Nattar; Koester, Helmut Joachim

    2011-01-01

    Propagation of suprathreshold spiking activity through neuronal populations is important for the function of the central nervous system. Neural correlations have an impact on cortical function particularly on the signaling of information and propagation of spiking activity. Therefore we measured the change in correlations as suprathreshold spiking activity propagated between recurrent neuronal networks of the mammalian cerebral cortex. Using optical methods we recorded spiking activity from large samples of neurons from two neural populations simultaneously. The results indicate that correlations decreased as spiking activity propagated from layer 4 to layer 2/3 in the rodent barrel cortex. PMID:21629764

  9. Precise mapping of the magnetic field in the CMS barrel yoke using cosmic rays

    SciTech Connect

    Chatrchyan, S.; et al.,

    2010-03-01

    The CMS detector is designed around a large 4 T superconducting solenoid, enclosed in a 12000-tonne steel return yoke. A detailed map of the magnetic field is required for the accurate simulation and reconstruction of physics events in the CMS detector, not only in the inner tracking region inside the solenoid but also in the large and complex structure of the steel yoke, which is instrumented with muon chambers. Using a large sample of cosmic muon events collected by CMS in 2008, the field in the steel of the barrel yoke has been determined with a precision of 3 to 8% depending on the location.

  10. Design, performance, and calibration of CMS hadron-barrel calorimeter wedges

    NASA Astrophysics Data System (ADS)

    Abdullin, S.; Abramov, V.; Acharya, B.; Adams, M.; Akchurin, N.; Akgun, U.; Anderson, E. W.; Antchev, G.; Ayan, S.; Aydin, S.; Baarmand, M.; Baden, D.; Banerjee, Sud.; Banerjee, Sun.; Bard, R.; Barnes, V.; Bawa, H.; Baiatian, G.; Bencze, G.; Beri, S.; Bhatnagar, V.; Bodek, A.; Budd, H.; Burchesky, K.; Camporesi, T.; Cankoçak, K.; Carrell, K.; Chendvankar, S.; Chung, Y.; Cremaldi, L.; Cushman, P.; Damgov, J.; de Barbaro, P.; Demianov, A.; de Visser, T.; Dimitrov, L.; Dugad, S.; Dumanoglu, I.; Duru, F.; Elias, J.; Elvira, D.; Emeliantchik, I.; Eno, S.; Ershov, A.; Eskut, E.; Fisher, W.; Freeman, J.; Gavrilov, V.; Genchev, V.; Gershtein, Y.; Golutvin, I.; Goncharov, P.; Grassi, T.; Green, D.; Gribushin, A.; Grinev, B.; Gülmez, E.; Gümüş, K.; Haelen, T.; Hagopian, S.; Hagopian, V.; Hauptman, J.; Hazen, E.; Heering, A.; Imboden, M.; Isiksal, E.; Jarvis, C.; Johnson, K.; Kaftanov, V.; Kalagin, V.; Karmgard, D.; Kalmani, S.; Katta, S.; Kaur, M.; Kaya, M.; Kayis-Topaksu, A.; Kellogg, R.; Khmelnikov, A.; Kisselevich, I.; Kodolova, O.; Kohli, J.; Kolossov, V.; Korablev, A.; Korneev, Y.; Kosarev, I.; Krinitsyn, A.; Krokhotin, A.; Kryshkin, V.; Kuleshov, S.; Kumar, A.; Kunori, S.; Polatoz, A.; Laasanen, A.; Lawlor, C.; Lazic, D.; Levchuk, L.; Litvintsev, D.; Litov, L.; Los, S.; Lubinsky, V.; Lukanin, V.; Machado, E.; Mans, J.; Massolov, V.; Mazumdar, K.; Merlo, J. P.; Mescheryakov, G.; Mestvirishvili, A.; Miller, M.; Mondal, N.; Nagaraj, P.; Norbeck, E.; O'Dell, V.; Olson, J.; Onel, Y.; Onengut, G.; Ozdes-Koca, N.; Ozkorucuklu, S.; Ozok, F.; Paktinat, S.; Patil, M.; Petrushanko, S.; Pikalov, V.; Piperov, S.; Podrasky, V.; Pompos, A.; Posch, C.; Qian, W.; Ralich, R.; Reddy, L.; Reidy, J.; Ruchti, R.; Rohlf, J.; Ronzhin, A.; Ryazanov, A.; Sanders, D. A.; Sanzeni, C.; Sarycheva, L.; Satyanarayana, B.; Schmidt, I.; Senchishin, V.; Sergeyev, S.; Serin-Zeyrek, M.; Sever, R.; Singh, J.; Sirunyan, A.; Skuja, A.; Sherwood, B.; Shumeiko, N.; Smirnov, V.; Sorokin, P.; Stefanovich, R.; Stolin, V.; Sudhakar, K.; Suzuki, I.; Talov, V.; Thomas, R.; Tully, C.; Turchanovich, L.; Ulyanov, A.; Vankov, I.; Vardanyan, I.; Verma, P.; Vesztergombi, G.; Vidal, R.; Vlassov, E.; Vodopiyanov, I.; Volkov, A.; Volodko, A.; Winn, D.; Whitmore, J.; Wu, S. X.; Zalan, P.; Zarubin, A.; Zeyrek, M.

    2008-05-01

    Extensive measurements have been made with pions, electrons and muons on four production wedges of the compact muon solenoid (CMS) hadron barrel (HB) calorimeter in the H2 beam line at CERN with particle momenta varying from 20 to 300 GeV/ c. The time structure of the events was measured with the full chain of preproduction front-end electronics running at 34 MHz. Moving-wire radioactive source data were also collected for all scintillator layers in the HB. The energy dependent time slewing effect was measured and tuned for optimal performance.

  11. A Photographic Atlas of Selected Regions of the Milky Way

    NASA Astrophysics Data System (ADS)

    Barnard, Edward Emerson; Orin Dobek, Foreword by Gerald

    2014-08-01

    Foreword Gerald Orin Dobek; Preface from the original Atlas; Introduction from the original Atlas; Bibliography from the original Atlas; Catalogue of 349 dark objects in the sky; Biography of Edward Emerson Barnard.

  12. ATLAS-1 Video News Release

    NASA Technical Reports Server (NTRS)

    1992-01-01

    Allen Kenitzer, from Marshall Space Flight Center (MSFC), narrates this NASA Kennedy Space Center video presenting a MSFC-Television news release describing the overall scientific objectives of the Atmospheric Laboratory for Applications in Science-1 (ATLAS-1) Spacelab mission. Byron Lichtenberg (NASA Science Astronaut) and Anthony O'Neil (ATLAS-1 Mission Manager) explain that the 13 sophisticated and complementary instruments carried in shuttle Atlantis' payload bay are designed to identify the chemical species in our atmosphere, to measure the Sun's energy falling on and entering the atmosphere, to study the behavior of charged particles in the electric and magnetic fields surrounding the earth, and to gather ultraviolet light from stars and galaxies. ATLAS-1 is the first Spacelab flight of the National Aeronautics and Space Administration's (NASA's) Mission to Planet Earth.

  13. ATLAS DQ2 Deletion Service

    NASA Astrophysics Data System (ADS)

    Oleynik, Danila; Petrosyan, Artem; Garonne, Vincent; Campana, Simone

    2012-12-01

    The ATLAS Distributed Data Management project DQ2 is responsible for the replication, access and bookkeeping of ATLAS data across more than 100 distributed grid sites. It also enforces data management policies decided on by the collaboration and defined in the ATLAS computing model. The DQ2 Deletion Service is one of the most important DDM services. This distributed service interacts with 3rd party grid middleware and the DQ2 catalogues to serve data deletion requests on the grid. Furthermore, it also takes care of retry strategies, check-pointing transactions, load management and fault tolerance. In this paper special attention is paid to the technical details which are used to achieve the high performance of service, accomplished without overloading either site storage, catalogues or other DQ2 components. Special attention is also paid to the deletion monitoring service that allows operators a detailed view of the working system.

  14. The Sudden Stratospheric Warming Atlas

    NASA Astrophysics Data System (ADS)

    Sjoberg, J. P.; Butler, A. H.; Seidel, D. J.

    2015-12-01

    Sudden stratospheric warmings (SSWs) are large and rapid temperature increases in the polar stratosphere associated with a complete reversal of the climatological westerly winds in wintertime. These extreme events can have substantial impacts on wintertime surface climate, such as cold air outbreaks over North America and Eurasia, or anomalous warming over Greenland. Here we promote our progress towards a new atlas of historical SSW events and their impacts on the surface. The SSW atlas contains a variety of metrics, time series, maps, and animations for individual SSW events. The atlas will allow users to examine the structure and development of individual SSWs, the variability between events, the surface impacts in temperature and precipitation, and the impacts of SSWs during years with certain tropospheric signatures, like El Niño or La Niña winters.

  15. Subcolumnar dendritic and axonal organization of spiny stellate and star pyramid neurons within a barrel in rat somatosensory cortex.

    PubMed

    Egger, Veronica; Nevian, Thomas; Bruno, Randy M

    2008-04-01

    Excitatory neurons at the level of cortical layer 4 in the rodent somatosensory barrel field often display a strong eccentricity in comparison with layer 4 neurons in other cortical regions. In rat, dendritic symmetry of the 2 main excitatory neuronal classes, spiny stellate and star pyramid neurons (SSNs and SPNs), was quantified by an asymmetry index, the dendrite-free angle. We carefully measured shrinkage and analyzed its influence on morphological parameters. SSNs had mostly eccentric morphology, whereas SPNs were nearly radially symmetric. Most asymmetric neurons were located near the barrel border. The axonal projections, analyzed at the level of layer 4, were mostly restricted to a single barrel except for those of 3 interbarrel projection neurons. Comparing voxel representations of dendrites and axon collaterals of the same neuron revealed a close overlap of dendritic and axonal fields, more pronounced in SSNs versus SPNs and considerably stronger in spiny L4 neurons versus extragranular pyramidal cells. These observations suggest that within a barrel dendrites and axons of individual excitatory cells are organized in subcolumns that may confer receptive field properties such as directional selectivity to higher layers, whereas the interbarrel projections challenge our view of barrels as completely independent processors of thalamic input. PMID:17656622

  16. ATLAS computing on CSCS HPC

    NASA Astrophysics Data System (ADS)

    Filipcic, A.; Haug, S.; Hostettler, M.; Walker, R.; Weber, M.

    2015-12-01

    The Piz Daint Cray XC30 HPC system at CSCS, the Swiss National Supercomputing centre, was the highest ranked European system on TOP500 in 2014, also featuring GPU accelerators. Event generation and detector simulation for the ATLAS experiment have been enabled for this machine. We report on the technical solutions, performance, HPC policy challenges and possible future opportunities for HEP on extreme HPC systems. In particular a custom made integration to the ATLAS job submission system has been developed via the Advanced Resource Connector (ARC) middleware. Furthermore, a partial GPU acceleration of the Geant4 detector simulations has been implemented.

  17. The ATLAS Positron Experiment -- APEX

    SciTech Connect

    Ahmad, I.; Back, B.B.; Betts, R.R.; Dunford, R.; Kutschera, W.; Rhein, M.D.; Schiffer, J.P.; Wilt, P.; Wuosmaa, A.; Austin, S.M.; Kashy, E.; Winfield, J.S.; Yurkon, J.E.; Bazin, D.; Calaprice, F.P.; Young, A.; Chan, K.C.; Chisti, A.; Chowhury, P.; Greenberg, J.S.; Kaloskamis, N.; Lister, C.J.; Fox, J.D.; Roa, E.; Freedman, S.; Maier, M.R.; Freer, M.; Gazes, S.; Hallin, A.L.; Liu, M.; Happ, T.; Perera, A.; Wolfs, F.L.H.; Trainor, T.; Wolanski, M. |

    1994-03-01

    APEX -- the ATLAS Positron Experiment -- is designed to measure electrons and positrons emitted in heavy-ion collisions. Its scientific goal is to gain insight into the puzzling positron-line phenomena observed at the GSI Darmstadt. It is in operation at the ATLAS accelerator at Argonne National Lab. The assembly of the apparatus is finished and beginning 1993 the first positrons produced in heavy-ion collisions were observed. The first full scale experiment was carried out in December 1993, and the data are currently being analyzed. In this paper, the principles of operation are explained and a status report on the experiment is given.

  18. Liquid Argon Calorimetry for ATLAS

    NASA Astrophysics Data System (ADS)

    Robinson, Alan

    2008-05-01

    This summer, the largest collaborative physics project since the Manhattan project will go online. One of four experiments for the Large Hadron Collider at CERN in Geneva, ATLAS, employs over 2000 people. Canadians have helped design, construct, and calibrate the liquid argon calorimeters for ATLAS to capture the products of the high energy collisions produced by the LHC. From an undergraduate's perspective, explore how these calorimeters are made to handle their harsh requirement. From nearly a billion proton-proton collisions a second, physicists hope to discover the Higgs boson and other new fundamental particles.

  19. Ground and satellite EMIC wave observations in conjunction with BARREL electron precipitation

    NASA Astrophysics Data System (ADS)

    Weaver, C.; Lessard, M.; Engebretson, M. J.; Millan, R. M.; Halford, A.; Horne, R. B.; Singer, H. J.; Green, J. C.

    2013-12-01

    Ground-based and satellite observations of electromagnetic ion-cyclotron (EMIC) waves are presented in conjunction with electron precipitation detected by high altitude balloons from the Balloon Array for RBSP Relativistic Electron Losses (BARREL) campaign. On 17 Jan 2013, a high density solar wind compressed the magnetosphere and four satellites (GOES 13 & 15, Van Allen Probes A & B) as well as several ground stations (Dawson City, Canada and Halley, Antarctica) detected simultaneous EMIC waves across the night sector for about 2.5 hours during the compression (0130 - 0400 UT). The satellites and ground stations cover approximately 10 hours of magnetic local time and four L-shells, suggesting the generation region(s) covers the same extended area. At the strongest point of the compression (around 0300 UT with proton density 50 n/cc, flow pressure 20 nPa, SYM/H 50 nT) BARREL balloon 1G, which magnetically mapped close to GOES 13, detected relativistic electron precipitation concurrently with enhanced EMIC wave activity on GOES 13, which may show a direct observation of EMIC waves scattering relativistic electrons.

  20. Fluorescent protein barrel fluctuations and oxygen diffusion pathways in mCherry

    NASA Astrophysics Data System (ADS)

    Chapagain, Prem P.; Regmi, Chola K.; Castillo, William

    2011-12-01

    Fluorescent proteins (FPs) are valuable tools as biochemical markers for studying cellular processes. Red fluorescent proteins (RFPs) are highly desirable for in vivo applications because they absorb and emit light in the red region of the spectrum where cellular autofluorescence is low. The naturally occurring fluorescent proteins with emission peaks in this region of the spectrum occur in dimeric or tetrameric forms. The development of mutant monomeric variants of RFPs has resulted in several novel FPs known as mFruits. Though oxygen is required for maturation of the chromophore, it is known that photobleaching of FPs is oxygen sensitive, and oxygen-free conditions result in improved photostabilities. Therefore, understanding oxygen diffusion pathways in FPs is important for both photostabilites and maturation of the chromophores. In this paper, we use molecular dynamics calculations to investigate the protein barrel fluctuations in mCherry, which is one of the most useful monomeric mFruit variant. We employ implicit ligand sampling to determine oxygen pathways from the bulk solvent into the mCherry chromophore in the interior of the protein. We also show that these pathways can be blocked or altered and barrel fluctuations can be reduced by strategic amino acid substitutions.

  1. A New Four-Barrel Pellet Injection System for the TJ-II Stellarator

    SciTech Connect

    Combs, Stephen Kirk; Foust, Charles R; McGill, James M; Baylor, Larry R; Caughman, John B; Fehling, Dan T; Harris, Jeffrey H; Meitner, Steven J; Rasmussen, David A; McCarthy, K. J.; Chamorro, M.; Garcia, R.; Hildago, C.; Medrano, M.; Unamuno, R.

    2011-01-01

    A new pellet injection system for the TJ-II stellarator has been developed/constructed as part of a collaboration between the Oak Ridge National Laboratory (ORNL) and the Centro de Investigaciones Energ ticas, Medioambientales y Tecnol gicas (CIEMAT). ORNL is providing most of the injector hardware and instrumentation, the pellet diagnostics, and the pellet transport tubes; CIEMAT is responsible for the injector stand/interface to the stellarator, cryogenic refrigerator, vacuum pumps/ballast volumes, gas manifolds, remote operations, plasma diagnostics, and data acquisition. The pellet injector design is an upgraded version of that used for the ORNL injector installed on the Madison Symmetric Torus (MST). It is a four-barrel system equipped with a cryogenic refrigerator for in situ hydrogen pellet formation and a combined mechanical punch/propellant valve system for pellet acceleration (speeds ~100 to 1000 m/s). On TJ-II, it will be used as an active diagnostic and for fueling. To accommodate the plasma experiments planned for TJ-II, pellet sizes significantly smaller than those typically used for the MST application are required. The system will initially be equipped with four different pellet sizes, with the gun barrel bores ranging between ~0.5 to 1.0 mm. The new system is almost complete and is described briefly here, highlighting the new features added since the original MST injector was constructed. Also, the future installation on TJ-II is reviewed.

  2. Optogenetic Patterning of Whisker-Barrel Cortical System in Transgenic Rat Expressing Channelrhodopsin-2

    PubMed Central

    Yokoyama, Yukinobu; Sumiyoshi, Akira; Shibuya, Yuma; Matsuzaka, Yoshiya; Kawashima, Ryuta; Mushiake, Hajime; Ishizuka, Toru; Yawo, Hiromu

    2014-01-01

    The rodent whisker-barrel system has been an ideal model for studying somatosensory representations in the cortex. However, it remains a challenge to experimentally stimulate whiskers with a given pattern under spatiotemporal precision. Recently the optogenetic manipulation of neuronal activity has made possible the analysis of the neuronal network with precise spatiotemporal resolution. Here we identified the selective expression of channelrhodopsin-2 (ChR2), an algal light-driven cation channel, in the large mechanoreceptive neurons in the trigeminal ganglion (TG) as well as their peripheral nerve endings innervating the whisker follicles of a transgenic rat. The spatiotemporal pattern of whisker irradiation thus produced a barrel-cortical response with a specific spatiotemporal pattern as evidenced by electrophysiological and functional MRI (fMRI) studies. Our methods of generating an optogenetic tactile pattern (OTP) can be expected to facilitate studies on how the spatiotemporal pattern of touch is represented in the somatosensory cortex, as Hubel and Wiesel did in the visual cortex. PMID:24695456

  3. Summary of types of precipitation events observed by BARREL during storms.

    NASA Astrophysics Data System (ADS)

    Halford, A. J.; Millan, R. M.; Chakrabarti, S.; Woodger, L. A.; Kavanagh, A. J.

    2015-12-01

    In this poster we summarize the types of storm time precipitation observed by BARREL. One storm will be specifically highlighted which occurred on 26 January 2013 when a solar wind shock hit the Earth. After impact, electromagnetic ion cyclotron (EMIC) waves, observed both on the ground and with the Van Allen Probes, and relativistic electron precipitation (REP) were observed. A few hours later a substorm injection, observed by GOES and LANL, led to 100s keV electron precipitation. Throughout the substorm microbursts were clearly observed. Both during the REP as well as during the substorm precipitation, ULF time scale modulation of the X-rays was observed. This storm period also covered a time period where ~150 keV electron precipitation was observed to correlate well with drift echoes at 300 keV. This last event has not yet been fully explained. We will also present new results from storm periods during the second and third (Swedish) BARREL campaigns. We hope to be able to include results from conjunctions with EISCAT Tromso radar and HiT&MIS, a day time auroral imager, along with the current heliospheric fleet of satellites.

  4. The barrel DIRC detector for the P¯ ANDA experiment at FAIR

    NASA Astrophysics Data System (ADS)

    Schwiening, J.; P¯ Group; ANDA Cherenkov Group

    2011-05-01

    The P¯ANDA experiment at FAIR will perform high precision experiments in the charmed quark sector using cooled antiproton beams of unprecedented intensities of L=2×10 32 cm -2 s -1 in the momentum range of 1-15 GeV/ c. The charged particle identification in the barrel region needs a thin detector operating in a strong magnetic field. A ring imaging Cherenkov detector using the DIRC principle is an excellent match to those requirements. This article describes aspects of the design and R&D for the P¯ANDA barrel DIRC detector. The availability of highly pixelated fast photon detectors allows several key improvements compared to the successful BaBar-DIRC detector, some of which were tested in a proton beam at GSI. The optical properties of the radiator bars, made from synthetic fused silica, are critical to the success of the DIRC. Measurements of the attenuation length and reflection coefficient allow the determination of the surface roughness of prototype radiator bars.

  5. Insight into the Assembly of Viruses with Vertical Single β-barrel Major Capsid Proteins.

    PubMed

    Gil-Carton, David; Jaakkola, Salla T; Charro, Diego; Peralta, Bibiana; Castaño-Díez, Daniel; Oksanen, Hanna M; Bamford, Dennis H; Abrescia, Nicola G A

    2015-10-01

    Archaeal viruses constitute the least explored niche within the virosphere. Structure-based approaches have revealed close relationships between viruses infecting organisms from different domains of life. Here, using biochemical and cryo-electron microscopy techniques, we solved the structure of euryarchaeal, halophilic, internal membrane-containing Haloarcula hispanica icosahedral virus 2 (HHIV-2). We show that the density of the two major capsid proteins (MCPs) recapitulates vertical single β-barrel proteins and that disulfide bridges stabilize the capsid. Below, ordered density is visible close to the membrane and at the five-fold vertices underneath the host-interacting vertex complex underpinning membrane-protein interactions. The HHIV-2 structure exemplifies the division of conserved architectural elements of a virion, such as the capsid, from those that evolve rapidly due to selective environmental pressure such as host-recognizing structures. We propose that in viruses with two vertical single β-barrel MCPs the vesicle is indispensable, and membrane-protein interactions serve as protein-railings for guiding the assembly. PMID:26320579

  6. The CMS electromagnetic calorimeter barrel upgrade for High-Luminosity LHC

    NASA Astrophysics Data System (ADS)

    Gras, Philippe; CMS Collaboration

    2015-02-01

    The High Luminosity LHC (HL-LHC) will provide unprecedented instantaneous and integrated luminosity. The lead tungstate crystals forming the barrel part of the CMS Electromagnetic Calorimeter (ECAL) will still perform well, even after the expected 3000 fb-1 at the end of HL-LHC. The scintillation light from the crystals is measured with avalanche photodiodes (APDs). Although the APDs will continue to be operational, there will be some increase in noise due to radiation-induced dark-currents. Triggering on electromagnetic objects with ~140 pileup events necessitates a change of the front-end electronics. New developments in high-speed optical links will allow single-crystal readout at 40 MHz to upgraded off-detector processors, allowing maximum flexibility and enhanced triggering possibilities. The very-front- end system will also be upgraded, to provide improved rejection of anomalous signals in the APDs as well as to mitigate the increase in APD noise. We are also considering lowering the ECAL barrel operating temperature from 18°C to about 8 ~10°C, in order to increase the scintillation light output and reduce the APD dark current.

  7. Microsecond acquisition of heterogeneous structure in the folding of a TIM barrel protein

    SciTech Connect

    Wu, Ying; Kondrashkina, Elena; Kayatekin, Can; Matthews, C. Robert; Bilsel, Osman

    2008-09-29

    The earliest kinetic folding events for ({beta}{alpha}){sub 8} barrels reflect the appearance of off-pathway intermediates. Continuous-flow microchannel mixing methods interfaced to small-angle x-ray scattering (SAXS), circular dichroism (CD), time-resolved Foerster resonant energy transfer (trFRET), and time-resolved fluorescence anisotropy (trFLAN) have been used to directly monitor global and specific dimensional properties of the partially folded state in the microsecond time range for a representative ({beta}{alpha}){sub 8} barrel protein. Within 150 {micro}s, the {alpha}-subunit of Trp synthase ({alpha}TS) experiences a global collapse and the partial formation of secondary structure. The time resolution of the folding reaction was enhanced with trFRET and trFLAN to show that, within 30 {micro}s, a distinct and autonomous partially collapsed structure has already formed in the N-terminal and central regions but not in the C-terminal region. A distance distribution analysis of the trFRET data confirmed the presence of a heterogeneous ensemble that persists for several hundreds of microseconds. Ready access to locally folded, stable substructures may be a hallmark of repeat-module proteins and the source of early kinetic traps in these very common motifs. Their folding free-energy landscapes should be elaborated to capture this source of frustration.

  8. Monitoring Backbone Hydrogen-Bond Formation in β-Barrel Membrane Protein Folding.

    PubMed

    Raschle, Thomas; Rios Flores, Perla; Opitz, Christian; Müller, Daniel J; Hiller, Sebastian

    2016-05-10

    β-barrel membrane proteins are key components of the outer membrane of bacteria, mitochondria and chloroplasts. Their three-dimensional structure is defined by a network of backbone hydrogen bonds between adjacent β-strands. Here, we employ hydrogen-deuterium (H/D) exchange in combination with NMR spectroscopy and mass spectrometry to monitor backbone hydrogen bond formation during folding of the outer membrane protein X (OmpX) from E. coli in detergent micelles. Residue-specific kinetics of interstrand hydrogen-bond formation were found to be uniform in the entire β-barrel and synchronized to formation of the tertiary structure. OmpX folding thus propagates via a long-lived conformational ensemble state in which all backbone amide protons exchange with the solvent and engage in hydrogen bonds only transiently. Stable formation of the entire OmpX hydrogen bond network occurs downhill of the rate-limiting transition state and thus appears cooperative on the overall folding time scale. PMID:27062600

  9. The CMS barrel calorimeter response to particle beams from 2 to 350 GeV/ c

    NASA Astrophysics Data System (ADS)

    Abdullin, S.; Abramov, V.; Acharya, B.; Adam, N.; Adams, M.; Adzic, P.; Akchurin, N.; Akgun, U.; Albayrak, E.; Alemany-Fernandez, R.; Almeida, N.; Anagnostou, G.; Andelin, D.; Anderson, E. W.; Anfreville, M.; Anicin, I.; Antchev, G.; Antunovic, Z.; Arcidiacono, R.; Arenton, M. W.; Auffray, E.; Argiro, S.; Askew, A.; Atramentov, O.; Ayan, S.; Arcidy, M.; Aydin, S.; Aziz, T.; Baarmand, M.; Babich, K.; Baccaro, S.; Baden, D.; Baffioni, S.; Bakirci, M. N.; Balazs, M.; Banerjee, Sud.; Banerjee, Sun.; Bard, R.; Barge, D.; Barnes, V.; Barney, D.; Barone, L.; Bartoloni, A.; Baty, C.; Bawa, H.; Baiatian, G.; Bandurin, D.; Beauceron, S.; Bell, K. W.; Bencze, G.; Benetta, R.; Bercher, M.; Beri, S.; Bernet, C.; Berntzon, L.; Berthon, U.; Besancon, M.; Betev, B.; Beuselinck, R.; Bhatnagar, V.; Bhatti, A.; Biino, C.; Blaha, J.; Bloch, P.; Blyth, S.; Bodek, A.; Bornheim, A.; Bose, S.; Bose, T.; Bourotte, J.; Brett, A. M.; Brown, R. M.; Britton, D.; Budd, H.; Buehler, M.; Burchesky, K.; Busson, P.; Camanzi, B.; Camporesi, T.; Cankoçak, K.; Carrell, K.; Carrera, E.; Cartiglia, N.; Cavallari, F.; Cerci, S.; Cerutti, M.; Chang, P.; Chang, Y. H.; Charlot, C.; Chen, E. A.; Chen, W. T.; Chen, Z.; Chendvankar, S.; Chipaux, R.; Choudhary, B. C.; Choudhury, R. K.; Chung, Y.; Clarida, W.; Cockerill, D. J. A.; Combaret, C.; Conetti, S.; Cossutti, F.; Cox, B.; Cremaldi, L.; Cushman, P.; Cussans, D. G.; Dafinei, I.; Damgov, J.; da Silva di Calafiori, D. R.; Daskalakis, G.; Davatz, G.; David, A.; de Barbaro, P.; Debbins, P.; Deiters, K.; Dejardin, M.; Djordjevic, M.; Deliomeroglu, M.; Della Negra, R.; Della Ricca, G.; Del Re, D.; Demianov, A.; de Min, A.; Denegri, D.; Depasse, P.; de Visser, T.; Descamps, J.; Deshpande, P. V.; Diaz, J.; Diemoz, M.; di Marco, E.; Dimitrov, L.; Dissertori, G.; Dittmar, M.; Djambazov, L.; Dobrzynski, L.; Drndarevic, S.; Duboscq, J. E.; Dugad, S.; Dumanoglu, I.; Duru, F.; Dutta, D.; Dzelalija, M.; Efthymiopoulos, I.; Elias, J.; Elliott-Peisert, A.; El Mamouni, H.; Elvira, D.; Emeliantchik, I.; Eno, S.; Ershov, A.; Erturk, S.; Esen, S.; Eskut, E.; Evangelou, I.; Evans, D. L.; Fabbro, B.; Faure, J. L.; Fay, J.; Fenyvesi, A.; Ferri, F.; Fisher, W.; Flower, P. S.; Franci, D.; Franzoni, G.; Freeman, J.; Freudenreich, K.; Funk, W.; Ganjour, S.; Gargiulo, C.; Gascon, S.; Gataullin, M.; Gaultney, V.; Gamsizkan, H.; Gavrilov, V.; Geerebaert, Y.; Genchev, V.; Gentit, F. X.; Gerbaudo, D.; Gershtein, Y.; Ghezzi, A.; Ghodgaonkar, M. D.; Gilly, J.; Givernaud, A.; Gleyzer, S.; Gninenko, S.; Go, A.; Gobbo, B.; Godinovic, N.; Golubev, N.; Golutvin, I.; Goncharov, P.; Gong, D.; Govoni, P.; Grant, N.; Gras, P.; Grassi, T.; Green, D.; Greenhalgh, R. J. S.; Gribushin, A.; Grinev, B.; Guevara Riveros, L.; Guillaud, J. P.; Gurtu, A.; Murat Güler, A.; Gülmez, E.; Gümüş, K.; Haelen, T.; Hagopian, S.; Hagopian, V.; Haguenauer, M.; Halyo, V.; Hamel de Monchenault, G.; Hansen, M.; Hashemi, M.; Hauptman, J.; Hazen, E.; Heath, H. F.; Heering, A.; Heister, A.; Heltsley, B.; Hill, J. A.; Hintz, W.; Hirosky, R.; Hobson, P. R.; Honma, A.; Hou, G. W. S.; Hsiung, Y.; Hunt, A.; Husejko, M.; Ille, B.; Ilyina, N.; Imlay, R.; Ingram, D.; Ingram, Q.; Isiksal, E.; Jarry, P.; Jarvis, C.; Jeong, C.; Jessop, C.; Johnson, K.; Jones, J.; Jovanovic, D.; Kaadze, K.; Kachanov, V.; Kaftanov, V.; Kailas, S.; Kalagin, V.; Kalinin, A.; Kalmani, S.; Karmgard, D.; Kataria, S. K.; Kaur, M.; Kaya, M.; Kaya, O.; Kayis-Topaksu, A.; Kellogg, R.; Kennedy, B. W.; Khmelnikov, A.; Kim, H.; Kisselevich, I.; Kloukinas, K.; Kodolova, O.; Kohli, J.; Kokkas, P.; Kolberg, T.; Kolossov, V.; Korablev, A.; Korneev, Y.; Kosarev, I.; Kramer, L.; Krasnikov, N.; Krinitsyn, A.; Krokhotin, A.; Krpic, D.; Kryshkin, V.; Kubota, Y.; Kubrik, A.; Kuleshov, S.; Kumar, A.; Kumar, P.; Kunori, S.; Kuo, C. M.; Kurt, P.; Kyberd, P.; Kyriakis, A.; Laasanen, A.; Ladygin, V.; Laird, E.; Landsberg, G.; Laszlo, A.; Lawlor, C.; Lazic, D.; Lebeau, M.; Lecomte, P.; Lecoq, P.; Ledovskoy, A.; Lee, S.-W.; Leshev, G.; Lethuillier, M.; Levchuk, L.; Lin, S. W.; Lin, W.; Linn, S.; Lintern, A. L.; Litvine, V.; Litvintsev, D.; Litov, L.; Lobolo, L.; Locci, E.; Lodge, A. B.; Longo, E.; Loukas, D.; Los, S.; Lubinsky, V.; Luckey, P. D.; Lukanin, V.; Lustermann, W.; Lynch, C.; Ma, Y.; Machado, E.; Mahlke-Krueger, H.; Maity, M.; Majumder, G.; Malberti, M.; Malclès, J.; Maletic, D.; Mandjavidze, I.; Mans, J.; Manthos, N.; Maravin, Y.; Marchica, C.; Marinelli, N.; Markou, A.; Markou, C.; Marlow, D.; Markowitz, P.; Marone, M.; Martinez, G.; Mathez, H.; Matveev, V.; Mavrommatis, C.; Maurelli, G.; Mazumdar, K.; Meridiani, P.; Merlo, J. P.; Mermerkaya, H.; Mescheryakov, G.; Mestvirishvili, A.; Mikhailin, V.; Milenovic, P.; Miller, M.; Milleret, G.; Miné, P.; Moeller, A.; Mohammadi-Najafabadi, M.; Mohanty, A. K.; Moissenz, P.

    2009-04-01

    The response of the CMS barrel calorimeter (electromagnetic plus hadronic) to hadrons, electrons and muons over a wide momentum range from 2 to 350 GeV/ c has been measured. To our knowledge, this is the widest range of momenta in which any calorimeter system has been studied. These tests, carried out at the H2 beam-line at CERN, provide a wealth of information, especially at low energies. The analysis of the differences in calorimeter response to charged pions, kaons, protons and antiprotons and a detailed discussion of the underlying phenomena are presented. We also show techniques that apply corrections to the signals from the considerably different electromagnetic (EB) and hadronic (HB) barrel calorimeters in reconstructing the energies of hadrons. Above 5 GeV/ c, these corrections improve the energy resolution of the combined system where the stochastic term equals 84.7±1.6% and the constant term is 7.4±0.8%. The corrected mean response remains constant within 1.3% rms.

  10. Large scale digital atlases in neuroscience

    NASA Astrophysics Data System (ADS)

    Hawrylycz, M.; Feng, D.; Lau, C.; Kuan, C.; Miller, J.; Dang, C.; Ng, L.

    2014-03-01

    Imaging in neuroscience has revolutionized our current understanding of brain structure, architecture and increasingly its function. Many characteristics of morphology, cell type, and neuronal circuitry have been elucidated through methods of neuroimaging. Combining this data in a meaningful, standardized, and accessible manner is the scope and goal of the digital brain atlas. Digital brain atlases are used today in neuroscience to characterize the spatial organization of neuronal structures, for planning and guidance during neurosurgery, and as a reference for interpreting other data modalities such as gene expression and connectivity data. The field of digital atlases is extensive and in addition to atlases of the human includes high quality brain atlases of the mouse, rat, rhesus macaque, and other model organisms. Using techniques based on histology, structural and functional magnetic resonance imaging as well as gene expression data, modern digital atlases use probabilistic and multimodal techniques, as well as sophisticated visualization software to form an integrated product. Toward this goal, brain atlases form a common coordinate framework for summarizing, accessing, and organizing this knowledge and will undoubtedly remain a key technology in neuroscience in the future. Since the development of its flagship project of a genome wide image-based atlas of the mouse brain, the Allen Institute for Brain Science has used imaging as a primary data modality for many of its large scale atlas projects. We present an overview of Allen Institute digital atlases in neuroscience, with a focus on the challenges and opportunities for image processing and computation.

  11. The Molecular Atlas Project

    NASA Astrophysics Data System (ADS)

    Silverberg, Jesse; Yin, Peng

    The promise of super-resolution microscopy is a technology to discover new biological mechanisms that occur at smaller length scales then previously observable. However, with higher-resolution, we generally lose the larger spatial context of the image itself. The Molecular Atlas Project (MAP) directly asks how these competing interests between super-resolution imaging and broader spatially contextualized information can be reconciled. MAP enables us to acquire, visualize, explore, and annotate proteomic image data representing 7 orders of magnitude in length ranging from molecular (nm) to tissue (cm) scales. This multi-scale understanding is made possible by combining multiplexed DNA-PAINT, a DNA nanotechnology approach to super-resolution imaging, with ``big-data'' strategies for information management and image visualization. With these innovations combined, MAP enables us to explore cell-specific heterogeneity in ductal carcinoma for every cellin a cm-sized tissue section, analyze organoid growth for advances in high-throughput tissue-on-a-chip technology, and examine individual synapses for connectome mapping over extremely wide areas. Ultimately, MAP is a fundamentally new way to interact with multiscale biophysical data.

  12. Anatomical Variant of Atlas : Arcuate Foramen, Occpitalization of Atlas, and Defect of Posterior Arch of Atlas

    PubMed Central

    2015-01-01

    Objective We sought to examine anatomic variations of the atlas and the clinical significance of these variations. Methods We retrospectively reviewed 1029 cervical 3-dimensional (3D) CT images. Cervical 3D CT was performed between November 2011 and August 2014. Arcuate foramina were classified as partial or complete and left and/or right. Occipitalization of the atlas was classified in accordance with criteria specified by Mudaliar et al. Posterior arch defects of the atlas were classified in accordance with criteria specified by Currarino et al. Results One hundred and eight vertebrae (108/1029, 10.5%) showed an arcuate foramen. Bilateral arcuate foramina were present in 41 of these vertebrae and the remaining 67 arcuate foramina were unilateral (right 31, left 36). Right-side arcuate foramina were partial on 18 sides and complete on 54 sides. Left-side arcuate foramina were partial on 24 sides and complete on 53 sides. One case of atlas assimilation was found. Twelve patients (12/1029, 1.17%) had a defect of the atlantal posterior arch. Nine of these patients (9/1029, 0.87%) had a type A posterior arch defect. We also identified one type B, one type D, and one type E defect. Conclusion Preoperative diagnosis of occipitalization of the atlas and arcuate foramina using 3D CT is of paramount importance in avoiding neurovascular injury during surgery. It is important to be aware of posterior arch defects of the atlas because they may be misdiagnosed as a fracture. PMID:26819687

  13. IERL-RTP PROCEDURES MANUAL: LEVEL 1 ENVIRONMENTAL ASSESSMENT BIOLOGICAL TESTS

    EPA Science Inventory

    The manual gives revised procedures for Level 1 environmental assessment biological tests, and supersedes the first edition, EPA-600/7-77-043 (NTIS No. PB 268484), published in April 1977. The revised biological procedures complement the Level 1 chemical and physical procedures p...

  14. Manual of Tape Scripts: Italian, Level 1. Curriculum Bulletin, 1968-69 Series, Number 12.

    ERIC Educational Resources Information Center

    Lipton, Gladys; And Others

    This manual of tape scripts, together with a set of foreign language audio tapes for level 1 Italian, was prepared to support the curriculum bulletin, New York City Foreign Language Program for Schools: Italian, Levels 1-4. Vocabulary, repetition, transformation, and recombination drills on specific grammatical features allow further development…

  15. Manual of Tape Scripts: German, Level 1. Curriculum Bulletin, 1968-69 Series, Number 11.

    ERIC Educational Resources Information Center

    Lipton, Gladys; And Others

    This manual of tape scripts, together with a set of foreign language audio tapes for level 1 German, was prepared to support the curriculum bulletin, New York City Foreign Language Program for Secondary Schools: German, Levels 1-4. Vocabulary, repetition, transformation, and recombination drills on specific grammatical features allow further…

  16. Alignment of the ATLAS Inner Detector Upgraded for the LHC Run II

    NASA Astrophysics Data System (ADS)

    Jiménez Peña, J.

    2015-12-01

    ATLAS is equipped with a tracking system built using different technologies, silicon planar sensors (pixel and micro-strip) and gaseous drift-tubes, all embedded in a 2T axial magnetic field. For the LHC Run II, the tracking system has been upgraded with the installation of a new pixel layer, the Insertable Barrel Layer (IBL). An outline of the track based alignment approach and its implementation within the ATLAS software will be presented. Special attention will be paid to integration in the alignment framework of the IBL, which plays a key role in precise reconstruction of the collider luminous region, interaction vertices and identification of long-lived heavy flavour states. In order to detect as soon as possible deformations and misalignments of the tracking system that may affect the data taking, a fast alignment chain was implemented at the Tier-0 at CERN. Latest upgrades and tests of this fast chain will be discussed, as well as the performance from the Cosmic Ray commissioning run.

  17. The Resistive Plate Chambers of the ATLAS experiment:. performance studies on Calibration Stream

    NASA Astrophysics Data System (ADS)

    Mazzaferro, Luca

    2012-08-01

    ATLAS (A Toroidal LHC ApparatuS) is one of the four experiments installed on the hadron-hadron collider LHC at CERN. It is a general purpose experiment, with a physics program which spans from the search for the Higgs Boson to the search of physics Beyond the Standard Model (BSM). An integrated luminosity of about 5 fb-1 is expected to be reached by the end of 2011. The Resistive Plate Chambers, installed in the barrel region, are used to provide the first muon level trigger, and cover an area of 16000 m2, readout by about 350000 electronic channels. To ensure optimal trigger performance, the RPC operational parameters like cluster size, efficiency and spatial resolution are constantly monitored. In order to achieve the desired precision, the data used for the analysis are extracted directly from the second level of the trigger, hence assuring very high statistics. This dedicated event stream, called Calibration Stream, is sent automatically to the RPC Calibration Center in Naples. Here the analysis is performed using an automatic tool tightly integrated in the ATLAS GRID environment, the Local Calibration Data Splitter (LCDS), which configures and manages all the operations required by the analysis (e.g. software environment initialization, grid jobs configuration and submission, data saving and retrieval, etc). The monitored RPC operational parameters, the performance analysis and the LCDS will be presented.

  18. A practical fan-beam design and reconstruction algorithm for Active and Passive Computed Tomography of radioactive waste barrels

    NASA Astrophysics Data System (ADS)

    Roy, Tushar; More, M. R.; Ratheesh, Jilju; Sinha, Amar

    2015-09-01

    Active and Passive CT (A&PCT) of waste barrels is mostly carried out in parallel beam configuration due to its relative ease of implementation. This necessitates either using a single detector-source pair and translating the barrel or using multiple detector-source pairs for increasing the scanning speed. Additionally, because the use of bulky HPGe detectors may limit the number of detectors used in both active and passive modes, we propose to use 1″×1″ LaBr3(Ce) scintillators. This paper describes a practical fan-beam reconstruction for A&PCT imaging of waste barrels. A fan beam system model has been computed analytically and reconstruction done using MLEM algorithm. The results are compared with analytical reconstruction.

  19. Establishing wild-type levels of catalytic activity on natural and artificial (βα)8-barrel protein scaffolds

    PubMed Central

    Claren, Jörg; Malisi, Christoph; Höcker, Birte; Sterner, Reinhard

    2009-01-01

    The generation of high levels of new catalytic activities on natural and artificial protein scaffolds is a major goal of enzyme engineering. Here, we used random mutagenesis and selection in vivo to establish a sugar isomerisation reaction on both a natural (βα)8-barrel enzyme and a catalytically inert chimeric (βα)8-barrel scaffold, which was generated by the recombination of 2 (βα)4-half barrels. The best evolved variants show turnover numbers and substrate affinities that are similar to those of wild-type enzymes catalyzing the same reaction. The determination of the crystal structure of the most proficient variant allowed us to model the substrate sugar in the novel active site and to elucidate the mechanistic basis of the newly established activity. The results demonstrate that natural and inert artificial protein scaffolds can be converted into highly proficient enzymes in the laboratory, and provide insights into the mechanisms of enzyme evolution. PMID:19237570

  20. Sam37 is crucial for formation of the mitochondrial TOM–SAM supercomplex, thereby promoting β-barrel biogenesis

    PubMed Central

    Wenz, Lena-Sophie; Ellenrieder, Lars; Qiu, Jian; Bohnert, Maria; Zufall, Nicole; van der Laan, Martin; Becker, Thomas

    2015-01-01

    Biogenesis of mitochondrial β-barrel proteins requires two preprotein translocases, the general translocase of the outer membrane (TOM) and the sorting and assembly machinery (SAM). TOM and SAM form a supercomplex that promotes transfer of β-barrel precursors. The SAM core complex contains the channel protein Sam50, which cooperates with Sam35 in precursor recognition, and the peripheral membrane protein Sam37. The molecular function of Sam37 has been unknown. We report that Sam37 is crucial for formation of the TOM–SAM supercomplex. Sam37 interacts with the receptor domain of Tom22 on the cytosolic side of the mitochondrial outer membrane and links TOM and SAM complexes. Sam37 thus promotes efficient transfer of β-barrel precursors to the SAM complex. We conclude that Sam37 functions as a coupling factor of the translocase supercomplex of the mitochondrial outer membrane. PMID:26416958

  1. Developmental decline in modulation of glutamatergic synapses in layer IV of the barrel cortex by group II metabotropic glutamate receptors.

    PubMed

    Mateo, Z; Porter, J T

    2015-04-01

    Previously, we demonstrated that group II metabotropic glutamate receptors (mGluRs) reduce glutamate release from thalamocortical synapses during early postnatal development (P7-11). To further examine the role of group II mGluRs in the modulation of somatosensory circuitry, we determined whether group II mGluRs continue to modulate thalamocortical synapses until adulthood and whether these receptors also modulate intra-cortical synapses in the barrel cortex. To address these issues, we examined the effect of the group II mGluR agonists on thalamocortical excitatory postsynaptic currents (EPSCs) and intra-barrel EPSCs in slices from animals of different ages (P7-53). We found that the depression of thalamocortical EPSCs by group II mGluRs rapidly declined after the second postnatal week. In contrast, adenosine continued to depress thalamocortical EPSCs via a presynaptic mechanism in young adult mice (P30-50). Activation of group II mGluRs also reduced intra-barrel EPSCs through a postsynaptic mechanism in young mice (P7-11). Similar to the thalamocortical synapses, the group II mGluR modulation of intra-barrel excitatory synapses declined with development. In young adult animals (P30-50), group II mGluR stimulation had little effect on intra-barrel EPSCs but did hyperpolarize the neurons. Together our results demonstrate that group II mGluRs modulate barrel cortex circuitry by presynaptic and postsynaptic mechanisms depending on the source of the synapse and that this modulation declines with development. PMID:25595969

  2. Developmental decline in modulation of glutamatergic synapses in layer IV of the barrel cortex by group II metabotropic glutamate receptors

    PubMed Central

    Mateo, Zaira; Porter, James T.

    2015-01-01

    Previously, we demonstrated that group II mGluRs reduce glutamate release from thalamocortical synapses during early postnatal development (P7–11). To further examine the role of group II mGluRs in the modulation of somatosensory circuitry, we determined whether group II mGluRs continue to modulate thalamocortical synapses until adulthood and whether these receptors also modulate intra-cortical synapses in the barrel cortex. To address these issues, we examined the effect of the group II mGluR agonists on thalamocortical EPSCs and intra-barrel EPSCs in slices from animals of different ages (P7–53). We found that the depression of thalamocortical EPSCs by stimulation group II mGluRs rapidly declined after the second postnatal week. In contrast, adenosine continued to depress thalamocortical EPSCs via a presynaptic mechanism in young adult mice (P30–50). Activation group II mGluRs also reduced intra-barrel EPSCs through a postsynaptic mechanism in young mice (P7–11). Similar to the thalamocortical synapses, the group II mGluR modulation of intra-barrel excitatory synapses declined with development. In young adult animals (P30–50), group II mGluR stimulation had little effect on intra-barrel EPSCs but did hyperpolarize the neurons. Together our results demonstrate that group II mGluRs modulate barrel cortex circuitry by presynaptic and postsynaptic mechanisms depending on the source of the synapse and that this modulation declines with development. PMID:25595969

  3. BARREL observations of an ICME-shock impact with the magnetosphere and the resultant radiation belt electron loss

    NASA Astrophysics Data System (ADS)

    Halford, A. J.; McGregor, S. L.; Murphy, K. R.; Millan, R. M.; Hudson, M. K.; Woodger, L. A.; Cattel, C. A.; Breneman, A. W.; Mann, I. R.; Kurth, W. S.; Hospodarsky, G. B.; Gkioulidou, M.; Fennell, J. F.

    2015-04-01

    The Balloon Array for Radiation belt Relativistic Electron Losses (BARREL) mission of opportunity working in tandem with the Van Allen Probes was designed to study the loss of radiation belt electrons to the ionosphere and upper atmosphere. BARREL is also sensitive to X-rays from other sources. During the second BARREL campaign, the Sun produced an X-class flare followed by a solar energetic particle event (SEP) associated with the same active region. Two days later on 9 January 2014, the shock generated by the coronal mass ejection (CME) originating from the active region hits the Earth while BARREL was in a close conjunction with the Van Allen Probes. Time History Events and Macroscale Interactions during Substorms (THEMIS) satellite observed the impact of the interplanetary CME (ICME) shock near the magnetopause, and the Geostationary Operational Environmental Satellites (GOES) were on either side of the BARREL/Van Allen Probe array. The solar interplanetary magnetic field was not ideally oriented to cause a significant geomagnetic storm, but compression from the shock impact led to the loss of radiation belt electrons. We propose that an azimuthal electric field impulse generated by magnetopause compression caused inward electron transport and minimal loss. This process also drove chorus waves, which were responsible for most of the precipitation observed outside the plasmapause. Observations of hiss inside the plasmapause explain the absence of loss at this location. ULF waves were found to be correlated with the structure of the precipitation. We demonstrate how BARREL can monitor precipitation following an ICME-shock impact at Earth in a cradle-to-grave view; from flare, to SEP, to electron precipitation.

  4. Atlas of Computed Tomography Variants

    SciTech Connect

    Kuhns, L.R.; Seeger, J.

    1983-01-01

    Atlas of Computed Tomography Variants is unique in that, while others of its kind may include plain film, roentgen variants, it concentrates solely on CT images of variants which may simulate disease. Organized into four regions, it presents dicussions covering CT variants of the skull, neck and spine; thorax; abdomen; and extremities-featuring a section on the head.

  5. Atlas of fetal skeletal radiology

    SciTech Connect

    Ornov, A.; Borochowitz, Z.; Lachman, R.; Rimoin, D.L.

    1987-01-01

    This atlas presents anterior, posterior and lateral views of normal but spontaneously aborted fetuses from 10 weeks through 27 weeks of gestation. The series of radiographs exhibits a wide array of skeletal dysplasia, and a chapter on the normal chondroosseous development - the formation of cartilage and bone and ossification of individual bones is included for further clarification.

  6. Atlas of the Soviet Union.

    ERIC Educational Resources Information Center

    Young, Harry F.

    This atlas consists of 20 maps, tables, charts, and graphs with complementary text illustrating Soviet government machinery, trade and political relations, and military stance. Some topics depicted by charts and graphs include: (1) Soviet foreign affairs machinery; (2) Soviet intelligence and security services; (4) Soviet position in the United…

  7. Pictorial Atlas of the Netherlands.

    ERIC Educational Resources Information Center

    Information and Documentation Centre for the Geography of the Netherlands, Utrecht.

    The atlas contains almost 40 photographs and 40 maps of geographical aspects of the Netherlands: the coast, dikes, canals, towns, and farmland. Each page contains a photograph, a section of a map showing the area in which the photograph was taken, and a discussion of several paragraphs about the geographical problems of the area and how they have…

  8. Atlas of Infrared Absorption Lines

    NASA Technical Reports Server (NTRS)

    Park, J. H.

    1977-01-01

    This atlas of infrared absorption line contains absorption line parameters (line strength vs. wavenumber) from 500 to 7000 cm(exp-1) for 15 gases: H2O, CO2, O3, N2O, CO, CH4, O2, SO2, NO, NO2, NH3, HCl, HF, HNO3 and CH3Cl.

  9. Event selection services in ATLAS

    NASA Astrophysics Data System (ADS)

    Cranshaw, J.; Cuhadar-Donszelmann, T.; Gallas, E.; Hrivnac, J.; Kenyon, M.; McGlone, H.; Malon, D.; Mambelli, M.; Nowak, M.; Viegas, F.; Vinek, E.; Zhang, Q.

    2010-04-01

    ATLAS has developed and deployed event-level selection services based upon event metadata records ("TAGS") and supporting file and database technology. These services allow physicists to extract events that satisfy their selection predicates from any stage of data processing and use them as input to later analyses. One component of these services is a web-based Event-Level Selection Service Interface (ELSSI). ELSSI supports event selection by integrating run-level metadata, luminosity-block-level metadata (e.g., detector status and quality information), and event-by-event information (e.g., triggers passed and physics content). The list of events that survive after some selection criterion is returned in a form that can be used directly as input to local or distributed analysis; indeed, it is possible to submit a skimming job directly from the ELSSI interface using grid proxy credential delegation. ELSSI allows physicists to explore ATLAS event metadata as a means to understand, qualitatively and quantitatively, the distributional characteristics of ATLAS data. In fact, the ELSSI service provides an easy interface to see the highest missing ET events or the events with the most leptons, to count how many events passed a given set of triggers, or to find events that failed a given trigger but nonetheless look relevant to an analysis based upon the results of offline reconstruction, and more. This work provides an overview of ATLAS event-level selection services, with an emphasis upon the interactive Event-Level Selection Service Interface.

  10. ATLAS DDM integration in ARC

    NASA Astrophysics Data System (ADS)

    Behrmann, G.; Cameron, D.; Ellert, M.; Kleist, J.; Taga, A.

    2008-07-01

    The Nordic Data Grid Facility (NDGF) consists of Grid resources running ARC middleware in Denmark, Finland, Norway and Sweden. These resources serve many virtual organisations and contribute a large fraction of total worldwide resources for the ATLAS experiment, whose data is distributed and managed by the DQ2 software. Managing ATLAS data within NDGF and between NDGF and other Grids used by ATLAS (the Enabling Grids for E-sciencE Grid and the Open Science Grid) presents a unique challenge for several reasons. Firstly, the entry point for data, the Tier 1 centre, is physically distributed among heterogeneous resources in several countries and yet must present a single access point for all data stored within the centre. The middleware framework used in NDGF differs significantly from other Grids, specifically in the way that all data movement and registration is performed by services outside the worker node environment. Also, the service used for cataloging the location of data files is different from other Grids but must still be useable by DQ2 and ATLAS users to locate data within NDGF. This paper presents in detail how we solve these issues to allow seamless access worldwide to data within NDGF.

  11. Atlas of the African Child.

    ERIC Educational Resources Information Center

    Patel, Mahesh, Ed.

    Using data primarily from United Nations Statistical Yearbooks, but from other sources as well, this Atlas provides an overview, in graphical form, of issues affecting children in Africa. Some of the issues covered, such as immunization, affect children directly. Others, such as economic progress, are included because they form part of the…

  12. The VLT Survey Telescope ATLAS

    NASA Astrophysics Data System (ADS)

    Shanks, T.; Metcalfe, N.; Chehade, B.; Findlay, J. R.; Irwin, M. J.; Gonzalez-Solares, E.; Lewis, J. R.; Yoldas, A. Kupcu; Mann, R. G.; Read, M. A.; Sutorius, E. T. W.; Voutsinas, S.

    2015-08-01

    The VLT Survey Telescope ATLAS survey is an optical ugriz survey aiming to cover ≈4700 deg2 of the southern sky to similar depths as the Sloan Digital Sky Survey (SDSS). From reduced images and object catalogues provided by the Cambridge Astronomical Surveys Unit, we first find that the median seeing ranges from 0.8 arcsec FWHM (full width at half-maximum) in i to 1.0 arcsec in u, significantly better than the 1.2-1.5 arcsec seeing for SDSS. The 5σ mag limit for stellar sources is rAB = 22.7 and in all bands these limits are at least as faint as SDSS. SDSS and ATLAS are more equivalent for galaxy photometry except in the z band where ATLAS has significantly higher throughput. We have improved the original ESO magnitude zero-points by comparing m < 16 star magnitudes with the AAVSO Photometric All-Sky Survey in gri, also extrapolating into u and z, resulting in zero-points accurate to ≈ ± 0.02 mag. We finally compare star and galaxy number counts in a 250 deg2 area with SDSS and other count data and find good agreement. ATLAS data products can be retrieved from the ESO Science Archive, while support for survey science analyses is provided by the OmegaCAM Science Archive, operated by the Wide-Field Astronomy Unit in Edinburgh.

  13. The Upgrade of the ATLAS Electron and Photon Triggers for LHC Run 2 and their Performance

    NASA Astrophysics Data System (ADS)

    Thomson, Evelyn; Atlas Collaboration

    2016-03-01

    Electron and photon triggers covering transverse energies from 5 GeV to several TeV are essential for signal selection in a wide variety of ATLAS physics analyses to study Standard Model processes and to search for new phenomena. Final states including leptons and photons had, for example, an important role in the discovery and measurement of the Higgs particle. Dedicated triggers are also used to collect data for calibration, efficiency and fake rate measurements. The ATLAS trigger system is divided in a hardware-based (Level 1) and a software based high level trigger (HLT), both of which were upgraded during the long shutdown of the LHC in preparation for data taking in 2015. The increasing luminosity and more challenging pile-up conditions as well as the planned higher center-of-mass energy demanded the optimisation of the trigger selections at each level, to control the rates and keep efficiencies high. To improve the performance multivariate analysis techniques are introduced at the HLT. The evolution of the ATLAS electron and photon triggers and their performance will be presented, including new results from the 2015 LHC Run 2 operation. Submitted on behalf of ATLAS electron and photon combined performance group. Speaker is yet to be chosen.

  14. The radiation qualification of a switch capacitor array controller for use in ATLAS

    NASA Astrophysics Data System (ADS)

    Buchanan, Norman J.

    A switch capacitor array controller for use in the ATLAS detector was radiation qualified. Five prototypes of the controller were examined: Xilinx XC4036XLA and XC2S150 field programmable gate arrays, an Altera EPF10K50 complex programmable logic device, a radiation-hardened DMILL and a deep sub-micron application-specific integrated circuit. All of the devices, except for the XC4036XLA device, were irradiated with x-rays to test for total ionizing dose effects. The XC2S150 and EPF10K50 devices showed increases in power supply current at average total ionizing doses of (331 +/- 29) Gy(SiO2) and (832 +/- 90) Gy(SiO2), respectively. The application specific integrated circuit devices showed no increases in power supply current when irradiated to doses anticipated during ATLAS operation. The XC4036XLA had a single-event upset saturation cross-section value of (1.3 +/- 0.2) x 10-10 cm2/device for the user defined circuit and (26 +/- 1) x 10-10 cm2/device for the configuration switches. The device exhibited a threshold energy of (22 +/- 1) MeV for proton-induced single-event upsets. It was estimated that if the XC4036XLA was used in ATLAS, one of the devices in the electro-magnetic barrel calorimeter would require a reconfiguration every 12 minutes on average. The DSM device had a single-event upset saturation cross-section of (5 +/- 1) x 10-13 cm 2/device and a single-event upset threshold energy of (44 +/- 24) MeV for upsets that could not be corrected. It was estimated that one uncorrectable upset would occur, on average, every 65 device·days of operation in ATLAS. One single-event latch-up was observed when the XC40346XLA was irradiated with 105 MeV protons. It was estimated, at the 95% confidence level, that the mean time between proton-induced latch-ups for the XC4036XLA in ATLAS would be between 388 device yr and 7.87 x 105 device·yr. No permanent single-event effects were observed in the application specific integrated circuits.

  15. The ATLAS Facility at Argonne National Laboratory

    SciTech Connect

    1997-07-01

    The Argonne Tandem Linac Accelerator System (ATLAS) is a superconducting low-energy heavy ion accelerator. Its primary purpose is to provide beams for research in nuclear structure physics. This report begins with a brief history of ATLAS and then describes the current design of the facility. Also summarized are the experimental equipment and research programs. It concludes with a proposal for turning ATLAS into a radioactive beam facility.

  16. ATLAS Inner Detector Event Data Model

    SciTech Connect

    ATLAS; Akesson, F.; Costa, M.J.; Dobos, D.; Elsing, M.; Fleischmann, S.; Gaponenko, A.; Gnanvo, K.; Keener, P.T.; Liebig, W.; Moyse, E.; Salzburger, A.; Siebel, M.; Wildauer, A.

    2007-12-12

    The data model for event reconstruction (EDM) in the Inner Detector of the ATLAS experiment is presented. Different data classes represent evolving stages in the reconstruction data flow, and specific derived classes exist for the sub-detectors. The Inner Detector EDM also extends the data model for common tracking in ATLAS and is integrated into the modular design of the ATLAS high-level trigger and off-line software.

  17. The GLAS Standard Data Products Specification-Level 1, Version 9

    NASA Technical Reports Server (NTRS)

    Lee, Jeffrey E.

    2013-01-01

    The Geoscience Laser Altimeter System (GLAS) is the primary instrument for the ICESat (Ice, Cloud and Land Elevation Satellite) laser altimetry mission. ICESat was the benchmark Earth Observing System (EOS) mission for measuring ice sheet mass balance, cloud and aerosol heights, as well as land topography and vegetation characteristics. From 2003 to 2009, the ICESat mission provided multi-year elevation data needed to determine ice sheet mass balance as well as cloud property information, especially for stratospheric clouds common over polar areas. It also provided topography and vegetation data around the globe, in addition to the polar-specific coverage over the Greenland and Antarctic ice sheets.This document defines the Level-1 GLAS standard data products. This document addresses the data flow, interfaces, record and data formats associated with the GLAS Level 1 standard data products. GLAS Level 1 standard data products are composed of Level 1A and Level 1B data products. The term standard data products refers to those EOS instrument data that are routinely generated for public distribution. The National Snow and Ice Data Center (NSDIC) distribute these products. Each data product has a unique Product Identification code assigned by the Senior Project Scientist. GLAS Level 1A and Level 1B Data Products are composed from those Level 0 data that have been reformatted or transformed to corrected and calibrated data in physical units at the full instrument rate and resolution.

  18. Alignment strategy for the ATLAS tracker

    SciTech Connect

    ATLAS; Golling, T.

    2007-09-23

    The ATLAS experiment is a multi-purpose particle detector that will study high-energy particle collisions produced by the Large Hadron Collider. For the reconstruction of charged particles, and their production and their decay vertices, ATLAS is equipped with a sophisticated tracking system, unprecedented in size and complexity. Full exploitation of both the Inner Detector and the muon spectrometer requires an accurate alignment. The challenge of aligning the ATLAS tracking devices is discussed, and the ATLAS alignment strategy is presented and illustrated with both data and Monte Carlo results.

  19. Glance Information System for ATLAS Management

    NASA Astrophysics Data System (ADS)

    Grael, F. F.; Maidantchik, C.; Évora, L. H. R. A.; Karam, K.; Moraes, L. O. F.; Cirilli, M.; Nessi, M.; Pommès, K.; ATLAS Collaboration

    2011-12-01

    ATLAS Experiment is an international collaboration where more than 37 countries, 172 institutes and laboratories, 2900 physicists, engineers, and computer scientists plus 700 students participate. The management of this teamwork involves several aspects such as institute contribution, employment records, members' appointment, authors' list, preparation and publication of papers and speakers nomination. Previously, most of the information was accessible by a limited group and developers had to face problems such as different terminology, diverse data modeling, heterogeneous databases and unlike users needs. Moreover, the systems were not designed to handle new requirements. The maintenance has to be an easy task due to the long lifetime experiment and professionals turnover. The Glance system, a generic mechanism for accessing any database, acts as an intermediate layer isolating the user from the particularities of each database. It retrieves, inserts and updates the database independently of its technology and modeling. Relying on Glance, a group of systems were built to support the ATLAS management and operation aspects: ATLAS Membership, ATLAS Appointments, ATLAS Speakers, ATLAS Analysis Follow-Up, ATLAS Conference Notes, ATLAS Thesis, ATLAS Traceability and DSS Alarms Viewer. This paper presents the overview of the Glance information framework and describes the privilege mechanism developed to grant different level of access for each member and system.

  20. A Deformable Atlas of the Laboratory Mouse

    PubMed Central

    Wang, Hongkai; Stout, David B.; Chatziioannou, Arion F.

    2015-01-01

    Purpose This paper presents a deformable mouse atlas of the laboratory mouse anatomy. This atlas is fully articulated and can be positioned into arbitrary body poses. The atlas can also adapt body weight by changing body length and fat amount. Procedures A training set of 103 micro-CT images was used to construct the atlas. A cage-based deformation method was applied to realize the articulated pose change. The weight-related body deformation was learned from the training set using a linear regression method. A conditional Gaussian model and thin-plate spline mapping were used to deform the internal organs following the changes of pose and weight. Results The atlas was deformed into different body poses and weights, and the deformation results were more realistic compared to the results achieved with other mouse atlases. The organ weights of this atlas matched well with the measurements of real mouse organ weights. This atlas can also be converted into voxelized images with labeled organs, pseudo CT images and tetrahedral mesh for phantom studies. Conclusions With the unique ability of articulated pose and weight changes, the deformable laboratory mouse atlas can become a valuable tool for preclinical image analysis. PMID:25049072

  1. Learning with the ATLAS experiment at CERN

    NASA Astrophysics Data System (ADS)

    Barnett, R. M.; Johansson, K. E.; Kourkoumelis, C.; Long, L.; Pequenao, J.; Reimers, C.; Watkins, P.

    2012-01-01

    With the start of the LHC, the new particle collider at CERN, the ATLAS experiment is also providing high-energy particle collisions for educational purposes. Several education projects—education scenarios—have been developed and tested on students and teachers in several European countries within the Learning with ATLAS@CERN project. These highly appreciated projects could become a new component in many teachers' classrooms. The Learning with ATLAS portal and the information on the ATLAS public website make it possible for teachers to design educational material for their own situations. To be able to work with real data adds a new dimension to particle physics explorations at school.

  2. Commissioning of the ATLAS pixel detector

    SciTech Connect

    ATLAS Collaboration; Golling, Tobias

    2008-09-01

    The ATLAS pixel detector is a high precision silicon tracking device located closest to the LHC interaction point. It belongs to the first generation of its kind in a hadron collider experiment. It will provide crucial pattern recognition information and will largely determine the ability of ATLAS to precisely track particle trajectories and find secondary vertices. It was the last detector to be installed in ATLAS in June 2007, has been fully connected and tested in-situ during spring and summer 2008, and is ready for the imminent LHC turn-on. The highlights of the past and future commissioning activities of the ATLAS pixel system are presented.

  3. Global GIS database; digital atlas of Africa

    USGS Publications Warehouse

    Hearn, P.P., Jr.; Hare, T.M.; Schruben, P.; Sherrill, D.; LaMar, C.; Tsushima, P.

    2001-01-01

    This CD-ROM contains a digital atlas of the countries of Africa. This atlas is part of a global database compiled from USGS and other data sources at a nominal scale of 1:1 million and is intended to be used as a regional-scale reference and analytical tool by government officials, researchers, the private sector, and the general public. The atlas includes free GIS software or may be used with ESRI's ArcView software. Customized ArcView tools, specifically designed to make this atlas easier to use, are also included.

  4. Image database for digital hand atlas

    NASA Astrophysics Data System (ADS)

    Cao, Fei; Huang, H. K.; Pietka, Ewa; Gilsanz, Vicente; Dey, Partha S.; Gertych, Arkadiusz; Pospiech-Kurkowska, Sywia

    2003-05-01

    Bone age assessment is a procedure frequently performed in pediatric patients to evaluate their growth disorder. A commonly used method is atlas matching by a visual comparison of a hand radiograph with a small reference set of old Greulich-Pyle atlas. We have developed a new digital hand atlas with a large set of clinically normal hand images of diverse ethnic groups. In this paper, we will present our system design and implementation of the digital atlas database to support the computer-aided atlas matching for bone age assessment. The system consists of a hand atlas image database, a computer-aided diagnostic (CAD) software module for image processing and atlas matching, and a Web user interface. Users can use a Web browser to push DICOM images, directly or indirectly from PACS, to the CAD server for a bone age assessment. Quantitative features on the examined image, which reflect the skeletal maturity, are then extracted and compared with patterns from the atlas image database to assess the bone age. The digital atlas method built on a large image database and current Internet technology provides an alternative to supplement or replace the traditional one for a quantitative, accurate and cost-effective assessment of bone age.

  5. Digital atlas for spinal x rays

    NASA Astrophysics Data System (ADS)

    Long, L. Rodney; Pillemer, Stanley R.; Goh, Gin-Hua; Berman, Lewis E.; Neve, Leif; Thoma, George R.; Premkumar, Ahalya; Ostchega, Yechiam; Lawrence, Reva C.; Altman, Roy D.; Lane, Nancy E.; Scott, William W., Jr.

    1997-05-01

    At the National Library of Medicine we are developing a digital atlas to serve as a reference tool for the interpretation of cervical and lumbar spine x-rays. The atlas contains representative images for four grades of severity for cervical/lumbar spondylolisthesis. A prototype version of the atlas has been built using images for which expert rheumatologist readers reached exact agreement in grading. The atlas functionality includes the ability to display cervical and lumbar anatomy, display of single images or multiple simultaneous images, image processing functions, and capability to ad user-defined images to the atlas. Images are selected for display by the user specifying feature and grade. Currently, the atlas runs on a Sun SPARC workstation under the Solaris operating system. THe initial use of the atlas is to aid in reading a collection of 17,000 NHANES II digitized x-rays. The atlas may also be used as a general digital reference tool for the standardized interpretation of digital x-rays for osteoarthritis. We are investigating further development of the atlas to accommodate a wider set of images, to operate on multiple platforms, and to be accessible via the WWW.

  6. Atlas SOHO Booster and Centaur Erection

    NASA Technical Reports Server (NTRS)

    1995-01-01

    The launch vehicle for the Solar Heliospheric Observatory (SOHO) mission is a two stage Atlas-IIAS (Atlas/Centaur). The Atlas, consists of a solid rocket booster stage powered by four Thiokol Castor IVA solid rocket boosters (SRB) and a core vehicle stage (booster and sustainer) powered by Rocketdyne MA-5A liquid propellant engines (RP-1 fuel and liquid oxygen). The multiple firing Centaur is powered by two Pratt and Whitney (RL10A-4) liquid hydrogen and liquid oxygen engines with extendible nozzles. This video shows the erection of the Atlas booster and transportation (to 36-B launching pad) and erection of the Centaur.

  7. A Pd8 Tetrafacial Molecular Barrel as Carrier for Water Insoluble Fluorophore.

    PubMed

    Roy, Bijan; Ghosh, Aloke Kumar; Srivastava, Shubhi; D'Silva, Patrick; Mukherjee, Partha Sarathi

    2015-09-23

    A new carbazole-based tetraimidazole ligand 1,3,6,8-tetra(1H-imidazol-1-yl)-9-methyl-9H-carbazole (L) has been synthesized. The unsymmetrical nature of L as well as the rotational freedom of imidazole donor moieties around C-N bond make it a special building unit, which upon treatment with cis-(tmeda)Pd(NO3)2 produced an unprecedented single linkage-isomeric Pd8 tetrafacial molecular nanobarrel (PSMBR-1) [tmeda = N,N,N',N'-tetramethylethane-1,2-diamine]. Unlike closed architectures, open barrel architecture of water-soluble PSMBR-1 makes it an ideal host for some water insoluble polyaromatic hydrocarbons in aqueous medium; one such inclusion complex coronene⊂PSMBR-1 was characterized by X-ray diffraction study. Moreover, the potential application of PSMBR-1 as carrier in aqueous medium for the transportation of water insoluble fluorophore (perylene) for live cell imaging is explored. PMID:26340646

  8. Fixing mechanism for a wireline core barrel of core drilling equipment

    SciTech Connect

    Nenkov, N.D.; Petrov, I.B.; Peev, S.P.

    1987-05-12

    This patent describes a wireline mechanism for removing a core barrel containing a core from within a hollow drill string carrying a hollow drill crown cutter on its lower end while the drill string is in position in the earth. The mechanism comprises a cylindrical fixer adapted to be mounted within the drill string coaxially thereof. A cap for attachment to a flexible elongated core-removing member is secured to the upper end of the fixer, a cylindrical hollow body is adapted to be mounted within the drill string coaxially thereof and generally below the fixer. A lower portion of the fixer is adapted to be telescoped within the upper portion of the cylindrical hollow body, a longitudinally extending stopper bar is connected to the upper part of the cylindrical hollow body, a locking bar and a nut connect the fixer to the lower part of the cylindrical hollow body.

  9. Twenty barrel in situ pipe gun type solid hydrogen pellet injector for the Large Helical Device.

    PubMed

    Sakamoto, Ryuichi; Motojima, Gen; Hayashi, Hiromi; Inoue, Tomoyuki; Ito, Yasuhiko; Ogawa, Hideki; Takami, Shigeyuki; Yokota, Mitsuhiro; Yamada, Hiroshi

    2013-08-01

    A 20 barrel solid hydrogen pellet injector, which is able to inject 20 cylindrical pellets with a diameter and length of between 3.0 and 3.8 mm at the velocity of 1200 m/s, has been developed for the purpose of direct core fueling in LHD (Large Helical Device). The in situ pipe gun concept with the use of compact cryo-coolers enables stable operation as a fundamental facility in plasma experiments. The combination of the two types of pellet injection timing control modes, i.e., pre-programing mode and real-time control mode, allows the build-up and sustainment of high density plasma around the density limit. The pellet injector has demonstrated stable operation characteristics during the past three years of LHD experiments. PMID:24007062

  10. Dosimetry assessments for the reactor pressure vessel and core barrel in UK PWR plant

    SciTech Connect

    Thornton, D.A.; Allen, D.A.; Huggon, A.P.; Picton, D.J.; Robinson, A.T.; Steadman, R.J.; Seren, T.; Lipponen, M.; Kekki, T.

    2011-07-01

    Specimens for the Sizewell B reactor pressure vessel (RPV) inservice steels surveillance program are irradiated inside eight capsules located within the reactor pressure vessel and loaded prior to commissioning. The periodic removal of these capsules and testing of their contents provides material properties data at intervals during the lifetime of the plant. Neutron activation measurements and radiation transport calculations play an essential role in assessing the neutron exposure of the specimens and RPV. Following the most recent withdrawal, seven capsules have now been removed covering nine cycles of reactor operation. This paper summarizes the dosimetry results of the Sizewell B surveillance program obtained to date. In addition to an overview of the calculational methodology it includes a review of the measurements. Finally, it describes an extension of the methodology to provide dosimetry recommendations for the core barrel and briefly discusses the results that were obtained. (authors)

  11. Light yield of Kuraray SCSF-78MJ scintillating fibers for the Gluex barrel calorimeter

    SciTech Connect

    Beattie, T D; Fischer, A P; Krueger, S T; Lolos, G J; Papandreou, Z; Plummer, E L; Semenov, A Yu; Semenova, I A; Sichello, L M; Teigro, L A; Smith, E S

    2014-09-01

    Over three quarters of a million 1-mm-diameter 4-m-long Kuraray double-clad SCSF-78MJ (blue-green) scintillating fibers have been used in the construction of the GlueX electromagnetic barrel calorimeter for the Hall D experimental program at Jefferson Lab. The quality of a random sample of 4,750 of these fibers was evaluated by exciting the fibers at their mid point using a 90Sr source in order to determine the light yield using a calibrated vacuum photomultiplier as the photosensor. A novel methodology was developed to extract the number of photoelectrons detected for measurements where individual photoelectron peaks are not discernible. The average number of photoelectrons from this sample of fibers was 9.17±0.6 at a source distance of 200 cm from the PMT.

  12. Light yield of Kuraray SCSF-78MJ scintillating fibers for the Gluex barrel calorimeter

    NASA Astrophysics Data System (ADS)

    Beattie, T. D.; Fischer, A. P.; Krueger, S. T.; Lolos, G. J.; Papandreou, Z.; Plummer, E. L.; Semenov, A. Yu.; Semenova, I. A.; Sichello, L. M.; Teigrob, L. A.; Smith, E. S.

    2014-12-01

    Over three quarters of a million 1-mm-diameter 4-m-long Kuraray double-clad SCSF-78MJ (blue-green) scintillating fibers have been used in the construction of the GlueX electromagnetic barrel calorimeter for the Hall D experimental program at Jefferson Lab. The quality of a random sample of 4750 of these fibers was evaluated by exciting the fibers at their mid point using a 90Sr source in order to determine the light yield using a calibrated vacuum photomultiplier as the photosensor. A novel methodology was developed to extract the number of photoelectrons detected for measurements where individual photoelectron peaks are not discernible. The average number of photoelectrons from this sample of fibers was 9.17±0.6 at a source distance of 200 cm from the PMT.

  13. Modulating lipid dynamics and membrane fluidity to drive rapid folding of a transmembrane barrel

    PubMed Central

    Maurya, Svetlana Rajkumar; Chaturvedi, Deepti; Mahalakshmi, Radhakrishnan

    2013-01-01

    Lipid-protein interactions, critical for the folding, stability and function of membrane proteins, can be both of mechanical and chemical nature. Mechanical properties of lipid systems can be suitably influenced by physical factors so as to facilitate membrane protein folding. We demonstrate here that by modulating lipid dynamics transiently using heat, rapid folding of two 8-stranded transmembrane β-barrel proteins OmpX and OmpA1–171, in micelles and vesicles, can be achieved within seconds. Folding kinetics using this ‘heat shock’ method shows a dramatic ten to several hundred folds increase in refolding rate along with ~100% folding efficiency. We establish that OmpX thus folded is highly thermostable even in detergent micelles, and retains structural characteristics comparable to the protein in bilayers. PMID:23771099

  14. The Barrel Calorimeter for the GlueX Experiment at Jefferson Lab

    NASA Astrophysics Data System (ADS)

    Papandreou, Zisis

    2013-04-01

    The GlueX experiment at Jefferson Lab will search for exotic hybrid mesons as evidence of gluonic excitations, in an effort to understand confinement in QCD. The key features of this compelling physics program will be presented together with an overview of the detector, focusing on the electromagnetic barrel calorimeter (BCAL). The BCAL is a ``spaghetti calorimeter,'' consisting of layers of corrugated lead sheets, interleaved with planes of 1-mm-diameter, double-clad, scintillating fibres, bonded in the lead grooves using optical epoxy. This detector will consist of 48 modules and will be readout using 3,840 large-area Multi-Photon Pixel counter arrays. The experiment is now in the installation phase with data taking expected in 2015.

  15. Characterization of the insertase for β-barrel proteins of the outer mitochondrial membrane

    PubMed Central

    Klein, Astrid; Israel, Lars; Lackey, Sebastian W.K.; Nargang, Frank E.; Imhof, Axel; Baumeister, Wolfgang

    2012-01-01

    The TOB–SAM complex is an essential component of the mitochondrial outer membrane that mediates the insertion of β-barrel precursor proteins into the membrane. We report here its isolation and determine its size, composition, and structural organization. The complex from Neurospora crassa was composed of Tob55–Sam50, Tob38–Sam35, and Tob37–Sam37 in a stoichiometry of 1:1:1 and had a molecular mass of 140 kD. A very minor fraction of the purified complex was associated with one Mdm10 protein. Using molecular homology modeling for Tob55 and cryoelectron microscopy reconstructions of the TOB complex, we present a model of the TOB–SAM complex that integrates biochemical and structural data. We discuss our results and the structural model in the context of a possible mechanism of the TOB insertase. PMID:23128244

  16. Performance of the prototype module of the GlueX electromagnetic barrel calorimeter

    SciTech Connect

    Leverington, Blake; Lolos, George; Papandreou, Zisis; Hakobyan, Rafael; Huber, Garth; Janzen, Kathryn; Semenov, Andrei; Scott, Eric; Shepherd, Matthew; Carman, Daniel; Lawrence, David; Smith, Elton; Taylor, Simon; Wolin, Elliott; Klein, Franz; Santoro, Joseph; Sober, Daniel; Kourkoumeli, Christina

    2008-11-01

    A photon beam test of the 4 m long prototype lead/scintillating-fibre module for the GlueX electromagnetic barrel calorimeter was carried out in Hall B at the Thomas Jefferson National Accelerator Facility with the objective of measuring the energy and timing resolutions of the module as well as the number of photoelectrons generated. Data were collected over an energy range of 150 - â 650 MeV at multiple positions and angles along the module. Details of the analysis at the centre of and perpendicular to the module are shown herein; the results are View the MathML source, View the MathML source ps, and 660 photoelectrons for 1 GeV at each end of the module.

  17. Detailed Surface Analysis Of Incremental Centrifugal Barrel Polishing (CBP) Of Single-Crystal Niobium Samples

    SciTech Connect

    Palczewski, Ari D.; Tian, Hui; Trofimova, Olga; Reece, Charles E.

    2011-07-01

    We performed Centrifugal Barrel Polishing (CBP) on single crystal niobium samples/coupons housed in a stainless steel sample holder following the polishing recipe developed at Fermi Lab (FNAL) in 2011 \\cite{C. A. Cooper 2011}. Post CBP, the sample coupons were analyzed for surface roughness, crystal composition and structure, and particle contamination. Following the initial analysis each coupon was high pressure rinsed (HRP) and analyzed for the effectiveness of contamination removal. We were able to obtain the mirror like surface finish after the final stage of tumbling, although some defects and embedded particles remained. In addition, standard HPR appears to have little effect on removing embedded particles which remain after each tumbling step, although final polishing media removal was partially affected by standard/extended HPR.

  18. Behavioral Modulation of Stimulus-Evoked Oscillations in Barrel Cortex of Alert Rats

    PubMed Central

    Venkatraman, Subramaniam; Carmena, Jose M.

    2009-01-01

    Stimulus-evoked oscillations have been observed in the visual, auditory, olfactory and somatosensory systems. To further our understanding of these oscillations, it is essential to study their occurrence and behavioral modulation in alert, awake animals. Here we show that microstimulation in barrel cortex of alert rats evokes 15–18 Hz oscillations that are strongly modulated by motor behavior. In freely whisking rats, we found that the power of the microstimulation-evoked oscillation in the local field potential was inversely correlated to the strength of whisking. This relationship was also present in rats performing a stimulus detection task suggesting that the effect was not due to sleep or drowsiness. Further, we present a computational model of the thalamocortical loop which recreates the observed phenomenon and predicts some of its underlying causes. These findings demonstrate that stimulus-evoked oscillations are strongly influenced by motor modulation of afferent somatosensory circuits. PMID:19521539

  19. A growing toolbox of techniques for studying β-barrel outer membrane protein folding and biogenesis

    PubMed Central

    Horne, Jim E.; Radford, Sheena E.

    2016-01-01

    Great strides into understanding protein folding have been made since the seminal work of Anfinsen over 40 years ago, but progress in the study of membrane protein folding has lagged behind that of their water soluble counterparts. Researchers in these fields continue to turn to more advanced techniques such as NMR, mass spectrometry, molecular dynamics (MD) and single molecule methods to interrogate how proteins fold. Our understanding of β-barrel outer membrane protein (OMP) folding has benefited from these advances in the last decade. This class of proteins must traverse the periplasm and then insert into an asymmetric lipid membrane in the absence of a chemical energy source. In this review we discuss old, new and emerging techniques used to examine the process of OMP folding and biogenesis in vitro and describe some of the insights and new questions these techniques have revealed. PMID:27284045

  20. A stable multiply twinned decahedral gold nanoparticle with a barrel-like shape

    NASA Astrophysics Data System (ADS)

    Santiago, Ulises; Velázquez-Salazar, J. Jesus; Sanchez, John Eder; Ruiz-Zepeda, Francisco; Ortega, José Eduardo; Reyes-Gasga, José; Bazán-Díaz, Lourdes; Betancourt, Israel; Rauch, Edgar F.; Veron, Muriel; Ponce, Arturo; José-Yacamán, Miguel

    2016-02-01

    In the present work we report a modified configuration of a multiply twinned decahedral barrel-like nanoparticle. The nanoparticle is stabilized by a selective chemical etching, which yielded a truncated shape with multiple high-index planes on the surface. The surface planes and the shape of the nanoparticle have been characterized using electron microscopy techniques, including scanning and transmission electron microscopies and electron diffraction. Coherent electron diffraction revealed streaked Bragg reflections which are in agreement with the high-index facets measured from electron microscope projected images. Crystal orientation mapping assisted by precession electron diffraction was performed under nanobeam conditions giving information about the structure from different orientations. The combination of these techniques allowed us to resolve the 3D structure of the modified nanoparticle and dismiss any possible ambiguities from the interpretation of the projected images in direct space.

  1. Repair of Erosion Defects in Gun Barrels by Direct Laser Deposition

    NASA Astrophysics Data System (ADS)

    Nowotny, Steffen; Spatzier, Joerg; Kubisch, Frank; Scharek, Siegfried; Ortner, Jens; Beyer, Eckhard

    2012-12-01

    In recent years the development of functional carbide coatings follows the trend to use composite powders with fine grained hard particles. In addition to thermal spraying, laser cladding is a suitable surface technology in particular for dynamically loaded components, and it is widely used for the manufacturing of coatings as well as complex 3D structures. The paper presents an application addressing the repair of erosion defects in large gun barrels using a novel internal diameter laser cladding head. The most promising material systems are TiC- and VC-based metal-matrix composites. Samples were evaluated in a special erosion test that emulates realistic load conditions. In this test, the materials are exposed to extreme stresses by temperature and pressure shocks, a very reactive atmosphere and erosive particles. As result, TiC-based coatings showed the best performance, and they are applicable for both repair and surface protection of inner surfaces of components and tools.

  2. OPTIMIZING CENTRIFUGAL BARREL POLISHING FOR MIRROR FINISH SRF CAVITY AND RF TESTS AT JEFFERSON LAB

    SciTech Connect

    Ari Palczewski, Rongli Geng, Hui Tian

    2012-07-01

    We performed Centrifugal Barrel Polishing (CBP) on a 1.3 GHz fine grain TESLA single cell cavity and 1.5 GHz fine grain CEBAF high gradient superconducting radio frequency (SRF) single cell cavity following a modified recipe originally developed at Fermi National Accelerator Lab (FNAL). We were able to obtain a mirror like surface similar to that obtained at FNAL, while reducing the number of CBP steps and total processing time. This paper will discuss the change in surface and subsequent cavity performance post CBP, after a 800 C bake (no pre-bake chemistry) and minimal controlled electro-polishing (10 micron). In addition to Q vs. E{sub ACC} thermometry mapping with preheating characteristics and optical inspection of the cavity after CBP will also be shown.

  3. High performance interactive graphics for shower reconstruction in HPC, the DELPHI barrel electromagnetic calorimeter

    SciTech Connect

    Stanescu, C. )

    1990-08-01

    Complex software for shower reconstruction in DELPHI barrel electromagnetic calorimeter which deals, for each event, with great amounts of information, due to the high spatial resolution of this detector, needs powerful verification tools. An interactive graphics program, running on high performance graphics display system Whizzard 7555 from Megatek, was developed to display the logical steps in showers and their axes reconstruction. The program allows both operations on the image in real-time (rotation, translation and zoom) and the use of non-geometrical criteria to modify it (as the use of energy) thresholds for the representation of the elements that compound the showers (or of the associated lego plots). For this purpose graphics objects associated to user parameters were defined. Instancing and modelling features of the native graphics library were extensively used.

  4. Tonically Active Inhibition Selectively Controls Feedforward Circuits in Mouse Barrel Cortex

    PubMed Central

    Krook-Magnuson, Esther I.; Li, Peijun; Paluszkiewicz, Scott M.; Huntsman, Molly M.

    2008-01-01

    Tonic inhibition mediated by extrasynaptic γ-aminobutyric acid type A (GABAA) receptors is a powerful conductance that controls cell excitability. Throughout the CNS, tonic inhibition is expressed at varying degrees across different cell types. Despite a rich history of cortical interneuron diversity, little is known about tonic inhibition in the different classes of cells in the cerebral cortex. We therefore examined the cell-type specificity and functional significance of tonic inhibition in layer 4 of the mouse somatosensory barrel cortex. In situ hybridization and immunocytochemistry showed moderate δ-subunit expression across the barrel structures. Whole cell patch-clamp recordings additionally indicated that significant levels of tonic inhibition can be found across cell types, with differences in the magnitude of inhibition between cell types. To activate tonic currents, we used 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP, a superagonist at δ-subunit–containing GABAA receptors) at a concentration that did not affect synaptic decay kinetics. THIP produced greater shifts in baseline holding current in inhibitory cells (low-threshold spiking [LTS], 109 ± 17 pA; fast spiking [FS], 111 ± 15 pA) than in excitatory cells (39 ± 10 pA; P < 0.001). In addition to these differences across cell types, there was also variability within inhibitory cells. FS cells with faster action potentials had larger baseline shifts. Because FS cells are known mediators of feedforward inhibition, we tested whether THIP-induced tonic conductance selectively controls feedforward circuits. THIP application resulted in the abolishment of the inhibitory postsynaptic potential in thalamic-evoked disynaptic responses in a subset of excitatory neurons. These data suggest multiple feedforward circuits can be differentiated by the inhibitory control of the presynaptic inhibitory neuron. PMID:18509076

  5. Lhx2 regulates a cortex-specific mechanism for barrel formation

    PubMed Central

    Shetty, Ashwin S.; Godbole, Geeta; Maheshwari, Upasana; Padmanabhan, Hari; Chaudhary, Rahul; Muralidharan, Bhavana; Hou, Pei-Shan; Monuki, Edwin S.; Kuo, Hung-Chih; Rema, V.; Tole, Shubha

    2013-01-01

    LIM homeodomain transcription factors are critical regulators of early development in multiple systems but have yet to be examined for a role in circuit formation. The LIM homeobox gene Lhx2 is expressed in cortical progenitors during development and also in the superficial layers of the neocortex in maturity. However, analysis of Lhx2 function at later stages of cortical development has been hampered by severe phenotypes associated with early loss of function. We identified a particular Cre-recombinase line that acts in the cortical primordium after its specification is complete, permitting an analysis of Lhx2 function in neocortical lamination, regionalization, and circuit formation by selective elimination of Lhx2 in the dorsal telencephalon. We report a profound disruption of cortical neuroanatomical and molecular features upon loss of Lhx2 in the cortex from embryonic day 11.5. A unique feature of cortical circuitry, the somatosensory barrels, is undetectable, and molecular patterning of cortical regions appears disrupted. Surprisingly, thalamocortical afferents innervate the mutant cortex with apparently normal regional specificity. Electrophysiological recordings reveal a loss of responses evoked by stimulation of individual whiskers, but responses to simultaneous stimulation of multiple whiskers were present, suggesting that thalamic afferents are unable to organize the neurocircuitry for barrel formation because of a cortex-specific requirement of Lhx2. We report that Lhx2 is required for the expression of transcription factor paired box gene 6, axon guidance molecule Ephrin A5, and the receptor NMDA receptor 1. These genes may mediate Lhx2 function in the formation of specialized neurocircuitry necessary for neocortical function. PMID:24262147

  6. Revisiting the oligomerization mechanism of Vibrio cholerae cytolysin, a beta-barrel pore-forming toxin.

    PubMed

    Rai, Anand Kumar; Chattopadhyay, Kausik

    2016-06-01

    Vibrio cholerae cytolysin (VCC) is a membrane-damaging beta-barrel pore-forming toxin (beta-PFT). VCC causes permeabilization of the target membranes by forming transmembrane oligomeric beta-barrel pores. Oligomerization is a key step in the mode of action of any beta-PFT, including that of VCC. Earlier studies have identified some of the key residues in VCC that are directly involved in the generation of the inter-protomer contacts, thus playing critical roles in the oligomerization of the membrane-bound toxin. Analysis of the VCC oligomeric pore structure reveals a potential hydrogen-bond network that appears to connect the sidechain of an asparagine residue (Asn582; located within an inter-domain linker sequence) from one protomer to the backbone CO- and NH-groups of the neighbouring protomer, indirectly through water molecules at most of the inter-protomer interfaces. In the present study, we show that the mutation of Asn582Ala affects the oligomerization and the pore-forming activity of VCC in the membrane lipid bilayer of the synthetic lipid vesicles, while the replacement of Asn582Gln results into the restoration of the oligomeric pore-forming ability of the toxin. Using a number of truncated variants of VCC, having deletion in the C-terminal region of the toxin starting from the Asn582 residue or beyond, we also show that the presence of Asn582 is critically required for the oligomerization of the truncated form of the protein. PMID:27150630

  7. Developmental Switch in Neurovascular Coupling in the Immature Rodent Barrel Cortex

    PubMed Central

    Zehendner, Christoph M.; Tsohataridis, Simeon; Luhmann, Heiko J.; Yang, Jenq-Wei

    2013-01-01

    Neurovascular coupling (NVC) in the adult central nervous system (CNS) is a mechanism that provides regions of the brain with more oxygen and glucose upon increased levels of neural activation. Hemodynamic changes that go along with neural activation evoke a blood oxygen level-dependent (BOLD) signal in functional magnetic resonance imaging (fMRI) that can be used to study brain activity non-invasively. A correct correlation of the BOLD signal to neural activity is pivotal to understand this signal in neuronal development, health and disease. However, the function of NVC during development is largely unknown. The rodent whisker-to-barrel cortex is an experimentally well established model to study neurovascular interdependences. Using extracellular multi-electrode recordings and laser-Doppler-flowmetry (LDF) we show in the murine barrel cortex of postnatal day 7 (P7) and P30 mice in vivo that NVC undergoes a physiological shift during the first month of life. In the mature CNS it is well accepted that cortical sensory processing results in a rise in regional cerebral blood flow (rCBF). We show in P7 animals that rCBF decreases during prolonged multi-whisker stimulation and goes along with multi unit activity (MUA) fatigue. In contrast at P30, MUA remains stable during repetitive stimulation and is associated with an increase in rCBF. Further we characterize in both age groups the responses in NVC to single sensory stimuli. We suggest that the observed shift in NVC is an important process in cortical development that may be of high relevance for the correct interpretation of brain activity e.g. in fMRI studies of the immature central nervous system (CNS). PMID:24224059

  8. Material wear and failure mode analysis of breakfast cereal extruder barrels and screw elements

    NASA Astrophysics Data System (ADS)

    Mastio, Michael Joseph, Jr.

    2005-11-01

    Nearly seventy-five years ago, the single screw extruder was introduced as a means to produce metal products. Shortly after that, the extruder found its way into the plastics industry. Today much of the world's polymer industry utilizes extruders to produce items such as soda bottles, PVC piping, and toy figurines. Given the significant economical advantages of extruders over conventional batch flow systems, extruders have also migrated into the food industry. Food applications include the meat, pet food, and cereal industries to name just a few. Cereal manufacturers utilize extruders to produce various forms of Ready-to-Eat (RTE) cereals. These cereals are made from grains such as rice, oats, wheat, and corn. The food industry has been incorrectly viewed as an extruder application requiring only minimal energy control and performance capability. This misconception has resulted in very little research in the area of material wear and failure mode analysis of breakfast cereal extruders. Breakfast cereal extruder barrels and individual screw elements are subjected to the extreme pressures and temperatures required to shear and cook the cereal ingredients, resulting in excessive material wear and catastrophic failure of these components. Therefore, this project focuses on the material wear and failure mode analysis of breakfast cereal extruder barrels and screw elements, modeled as a Discrete Time Markov Chain (DTMC) process in which historical data is used to predict future failures. Such predictive analysis will yield cost savings opportunities by providing insight into extruder maintenance scheduling and interchangeability of screw elements. In this DTMC wear analysis, four states of wear are defined and a probability transition matrix is determined based upon 24,041 hours of operational data. This probability transition matrix is used to predict when an extruder component will move to the next state of wear and/or failure. This information can be used to determine

  9. The ATLAS Trigger System: Ready for Run-2

    NASA Astrophysics Data System (ADS)

    Nakahama, Yu

    2015-12-01

    The ATLAS trigger system has been used very successfully for the online event selection during the LHC's first run (Run-1) between 2009 and 2013 at centre-of-mass energies (√s) between 900 GeV and 8 TeV. The trigger system consists of a hardware Level-1 (L1) and a software-based high-level trigger (HLT) that reduces the event rate from the design bunch-crossing rate of 40 MHz to an average recording rate of a few hundred Hz. During the next data-taking period (Run-2) starting in early 2015, the LHC will operate at √s = 13 TeV, resulting in roughly five times higher trigger rates. We will review the upgrades to the ATLAS trigger system that have been implemented during the long shutdown and that will allow us to cope with these increased trigger rates while maintaining or even improving our efficiencies to select relevant physics processes. These include changes to the L1 calorimeter trigger, the introduction of new L1 topological trigger modules, improvements in the L1 muon system and the merging of the previous two-level HLT system into a single event-filter farm. Finally, we will summarize the commissioning status of the trigger system in view of the imminent restart of data-taking.

  10. The Read Out Controller for the ATLAS New Small Wheel

    NASA Astrophysics Data System (ADS)

    Coliban, R.-M.; Popa, S.; Tulbure, T.; Nicula, D.; Ivanovici, M.; Martoiu, S.; Levinson, L.; Vermeulen, J.

    2016-02-01

    In the upgrade process of the ATLAS detector, the innermost stations of the endcaps (Small Wheels) will be replaced. The New Small Wheel will have two chamber technologies, small-strip Thin Gap Chambers and Micromegas, each providing triggering and precision track measurement. Custom front-end Application Specific Integrated Circuits will be used to read and filter information from both types of detectors. In the context of the New Small Wheel data path, the Read Out Controller ASIC is used for handling, preprocessing and formatting the data generated by the VMM upstream chips. The Read Out Controller will concentrate the data streams from 8 VMMs, filter data based on the ATLAS Level-1 trigger which identifies bunch crossings of interest and transmit the data to FELIX via the L1DDC. The Read Out Controller is composed of 8 VMM Capture modules, a cross-bar and 4 sROC modules. The output data is sent via up to 4 serial links with a configurable speed of 80, 160 or 320 Mbps per link.

  11. 78 FR 13085 - Proposed Collection, Comments Requested: FBI National Academy Level 1 Evaluation: Student Course...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-26

    ... Federal Bureau of Investigation Proposed Collection, Comments Requested: FBI National Academy Level 1...-day notice. The Department of Justice (DOJ), Federal Bureau of Investigation (FBI), Training Division... Laleatha B. Goode, Management and Program Analyst, Federal Bureau of Investigation, Training......

  12. IERL-RTP PROCEDURES MANUAL: LEVEL 1. ENVIRONMENTAL ASSESSMENT BIOLOGICAL TESTS FOR PILOT STUDIES

    EPA Science Inventory

    The manual gives Level 1 biological testing procedures (recommended by Industrial Environmental Research Laboratory--Research Triangle Park) for personnel experienced in conducting bioassays on samples from industrial and energy producing processes. The phased environmental asses...

  13. BOREAS RSS-14 Level-1a GOES-8 Visible, IR and Water Vapor Images

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Newcomer, Jeffrey A.; Faysash, David; Cooper, Harry J.; Smith, Eric A.

    2000-01-01

    The BOREAS RSS-14 team collected and processed several GOES-7 and GOES-8 image data sets that covered the BOREAS study region. The level-1a GOES-8 images were created by BORIS personnel from the level-1 images delivered by FSU personnel. The data cover 14-Jul-1995 to 21-Sep-1995 and 12-Feb-1996 to 03-Oct-1996. The data start out as three bands with 8-bit pixel values and end up as five bands with 10-bit pixel values. No major problems with the data have been identified. The differences between the level-1 and level-1a GOES-8 data are the formatting and packaging of the data. The images missing from the temporal series of level-1 GOES-8 images were zero-filled by BORIS staff to create files consistent in size and format. In addition, BORIS staff packaged all the images of a given type from a given day into a single file, removed the header information from the individual level-1 files, and placed it into a single descriptive ASCII header file. The data are contained in binary image format files. Due to the large size of the images, the level-1a GOES-8 data are not contained on the BOREAS CD-ROM set. An inventory listing file is supplied on the CD-ROM to inform users of what data were collected. The level-1a GOES-8 image data are available from the Earth Observing System Data and Information System (EOSDIS) Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC). See sections 15 and 16 for more information. The data files are available on a CD-ROM (see document number 20010000884).

  14. MODIS technical report series. Volume 3: MODIS airborne simulator level 1B data user's guide

    NASA Technical Reports Server (NTRS)

    Gumley, Liam E.; Hubanks, Paul A.; Masuoka, Edward J.

    1994-01-01

    The purpose of this document is to describe the characteristics of moderate resolution imaging spectroradiometer (MODIS) airborne simulator level 1B data, the calibration and geolocation methods used in processing, the structure and format of the level 1B data files, and methods for accessing the data. The MODIS airborne simulator is a scanning spectrometer which flies on a NASA ER-2 and provides spectral information similar to that which will be provided by the MODIS.

  15. TP0326, a Treponema pallidum β-Barrel Assembly Machinery A (BamA) Ortholog and Rare Outer Membrane Protein

    PubMed Central

    Desrosiers, Daniel C.; Anand, Arvind; Luthra, Amit; Dunham-Ems, Star M; LeDoyt, Morgan; Cummings, Michael A. D.; Eshghi, Azad; Cameron, Caroline E.; Cruz, Adriana R.; Salazar, Juan C.; Caimano, Melissa J.; Radolf, Justin D.

    2011-01-01

    SUMMARY Definitive identification of Treponema pallidum (Tp) rare outer membrane proteins (OMPs) has long eluded researchers. TP0326, the sole protein in Tp with sequence homology to a Gram-negative OMP, belongs to the BamA family of proteins essential for OM biogenesis. Structural modeling predicted that five polypeptide transport-associated (POTRA) domains comprise the N-terminus of TP0326, while the C-terminus forms an 18-stranded amphipathic β-barrel. Circular dichroism, heat-modifiability by SDS-PAGE, Triton X-114 phase partitioning and liposome incorporation supported these topological predictions and confirmed that the β-barrel is responsible for the native protein's amphiphilicity. Expression analyses revealed that native TP0326 is expressed at low abundance, while a protease-surface accessibility assay confirmed surface exposure. Size-exclusion chromatography and blue native polyacrylamide gel electrophoresis revealed a modular Bam complex in Tp considerably larger than that of E. coli. Non-orthologous ancillary factors and self-association of TP0326 via its β-barrel may both contribute to the Bam complex. Tp-infected rabbits mount a vigorous antibody response to both POTRA and β-barrel portions of TP0326, whereas humans with secondary syphilis respond predominantly to POTRA. The syphilis spirochete appears to have devised a stratagem for harnessing the Bam pathway while satisfying its need to limit surface antigenicity. PMID:21488980

  16. Deficiency of the microglial receptor CX3CR1 impairs postnatal functional development of thalamocortical synapses in the barrel cortex.

    PubMed

    Hoshiko, Maki; Arnoux, Isabelle; Avignone, Elena; Yamamoto, Nobuhiko; Audinat, Etienne

    2012-10-24

    Accumulative evidence indicates that microglial cells influence the normal development of brain synapses. Yet, the mechanisms by which these immune cells target maturating synapses and influence their functional development at early postnatal stages remain poorly understood. Here, we analyzed the role of CX3CR1, a microglial receptor activated by the neuronal chemokine CX3CL1 (or fractalkine) which controls key functions of microglial cells. In the whisker-related barrel field of the mouse somatosensory cortex, we show that the recruitment of microglia to the sites where developing thalamocortical synapses are concentrated (i.e., the barrel centers) occurs only after postnatal day 5 and is controlled by the fractalkine/CX3CR1 signaling pathway. Indeed, at this developmental stage fractalkine is overexpressed within the barrels and CX3CR1 deficiency delays microglial cell recruitment into the barrel centers. Functional analysis of thalamocortical synapses shows that CX3CR1 deficiency also delays the functional maturation of postsynaptic glutamate receptors which normally occurs at these synapses between the first and second postnatal week. These results show that reciprocal interactions between neurons and microglial cells control the functional maturation of cortical synapses. PMID:23100431

  17. Texture coarseness responsive neurons and their mapping in layer 2–3 of the rat barrel cortex in vivo

    PubMed Central

    Garion, Liora; Dubin, Uri; Rubin, Yoav; Khateb, Mohamed; Schiller, Yitzhak; Azouz, Rony; Schiller, Jackie

    2014-01-01

    Texture discrimination is a fundamental function of somatosensory systems, yet the manner by which texture is coded and spatially represented in the barrel cortex are largely unknown. Using in vivo two-photon calcium imaging in the rat barrel cortex during artificial whisking against different surface coarseness or controlled passive whisker vibrations simulating different coarseness, we show that layer 2–3 neurons within barrel boundaries differentially respond to specific texture coarsenesses, while only a minority of neurons responded monotonically with increased or decreased surface coarseness. Neurons with similar preferred texture coarseness were spatially clustered. Multi-contact single unit recordings showed a vertical columnar organization of texture coarseness preference in layer 2–3. These findings indicate that layer 2–3 neurons perform high hierarchical processing of tactile information, with surface coarseness embodied by distinct neuronal subpopulations that are spatially mapped onto the barrel cortex. DOI: http://dx.doi.org/10.7554/eLife.03405.001 PMID:25233151

  18. Analysis of refiners' total barrel costs and revenues from the sale of petroleum products, 1976 to 1979

    SciTech Connect

    1980-11-01

    In this report, the Economic Regulatory Administration has evaluated refiners' costs and revenues from the sale of major petroleum products from July 1976 through December 1979. This report represents a continuing effort to assess No. 2 heating oil prices and margins in that it updates prior middle distillate studies through March 1980. The analysis examines selling prices and costs associated with each major petroleum product category and a combination of petroleum products (total barrel) from a sample of nine refiners. The total barrel approach was adopted to reduce distortions caused by varying methods of allocation of costs among regulated and unregulated products by refiners. This report determines the extent to which increased costs were recovered on controlled products and whether refiners obtained greater cost recoupment on decontrolled products than would have been allowed under continued controls. The principal methods of measurement used to evaluate product pricing levels for the nine refiners surveyed were cost recoupment (Chapter III), gross margins (Chapter IV), and net margins (Chapter V). Gross margins were derived by subtracting average crude oil costs from average product selling prices for individual product categories and the total barrel. Net margins were derived by subtracting average crude oil costs as well as average marketing, manufacturing, and purchased product costs from average selling prices for individual product categories and the total barrel.

  19. Molecular Correlates of Cortical Network Modulation by Long-Term Sensory Experience in the Adult Rat Barrel Cortex

    ERIC Educational Resources Information Center

    Vallès, Astrid; Granic, Ivica; De Weerd, Peter; Martens, Gerard J. M.

    2014-01-01

    Modulation of cortical network connectivity is crucial for an adaptive response to experience. In the rat barrel cortex, long-term sensory stimulation induces cortical network modifications and neuronal response changes of which the molecular basis is unknown. Here, we show that long-term somatosensory stimulation by enriched environment…

  20. Missing Transverse Momentum Trigger Performance Studies for the ATLAS Calorimeter Trigger Upgrades

    NASA Astrophysics Data System (ADS)

    Stamas, Brianna; Parrish, Elliot; Lisi, Luc; Dudley, Christopher; Majewski, Stephanie

    2016-03-01

    The ATLAS Experiment is one of two general purpose detectors at the Large Hadron Collider at CERN in Geneva, Switzerland. In anticipation of discovering new physics, the detector will undergo numerous hardware upgrades including improvements to the Liquid Argon Calorimeter trigger electronics. For the upgrade, one component of the Level-1 trigger system will be the global feature extractor, gFEX, which will house three field programmable gate arrays (FPGAs). Specifically, in order to improve the missing transverse energy (ETmiss)trigger, an adapted topological clustering algorithm is being investigated for implementation on the FPGAs for reconstruction of proton-proton interactions in the ATLAS detector. Using simulated data, this study analyzes the performance of the adapted algorithm in software.

  1. Dead-time free pixel readout architecture for ATLAS front-end IC

    SciTech Connect

    Einsweiler, K.; Joshi, A.; Kleinfelder, S.; Luo, L.; Marchesini, R.; Milgrome, O.; Pengg, F.

    1999-06-01

    A low-power, sparse-scan, readout architecture has been developed for the ATLAS pixel front-end electronics. The architecture supports a dual discriminator and extracts the time over threshold (TOT) information along with a 2-D spatial address of the hits and associates them with a unique 7-bit beam crossing number. The IC implements level-1 trigger filtering along with event building (grouping together all hits in a beam crossing) in the end of column (EOC) buffer. The events are transmitted over a 40 MHz serial data link with the protocol supporting buffer overflow handling by appending error flags to events. This mixed-mode full custom IC is implemented in 0.8 {micro} HP process to meet the requirements for the pixel readout in the ATLAS inner detector. The circuits have been tested and the IC has been found to provide dead-time-less ambiguity-free readout at 40 MHz data rate.

  2. Emissions of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans from the open burning of household waste in barrels

    SciTech Connect

    Lemieux, P.M.; Lutes, C.C.; Abbott, J.A.; Aldous, K.M.

    2000-02-01

    Backyard burning of household waste in barrels is a common waste disposal practice for which pollutant emissions have not been well characterized. This study measured the emissions of several pollutants, including polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDDs/PCDFs), from burning mixtures designed to simulate waste generated by a recycling and a nonrecycling family in a 208-L (55-gal) burn barrel at the EPA's Open Burning Test Facility. This paper focuses on the PCDD/PCDF emissions and discusses the factors influencing PCDD/PCDF formation for different test burns. Four test burns were made in which the amount of waste placed in the barrel varied from 6.4 to 13.6 kg and the amount actually burned varied from 46.6% to 68.1%. Emissions of total PCDDs/PCDFs ranged between 0.0046 and 0.48 mg/kg of waste burned. Emissions are also presented in terms of 2,3,7,8-TCDD toxic equivalents. Emissions of PCDDs/PCDFs appear to correlate with both copper and hydrochloric acid emissions. The results of this study indicate that backyard burning emits more PCDDs/PCDFs on a mass of refuse burned basis than various types of municipal waste combustors (MWCs). Comparison of burn barrel emissions to emissions from a hypothetical modern MWC equipped with high-efficiency flue gas cleaning technology indicates that about 2--40 households burning their trash daily in barrels can produce average PCDD/PCDF emissions comparable to a 182,000 kg/day (200 ton/day) MWC facility. This study provides important data on a potentially significant source of emissions of PCDDs/PCDFs.

  3. Effect of a multi-sided concave liner barrel design on thickness and roughness of teat-end hyperkeratosis.

    PubMed

    Haeussermann, Angelika; Britten, Justine; Britten, Allan; Pahl, Christian; Älveby, Nils; Hartung, Eberhard

    2016-05-01

    In a round liner barrel, the force of the closing liner is transferred by the two opposite sides of the liner wall to the teat apex. Liners with a multi-sided barrel shape close at three or more planes and distribute their force to a larger area of the teat apex. The objective of the study was to investigate effects of a liner with a multi-sided concave barrel design on the degree of teat-end hyperkeratosis, thickness and roughness, and on the time delay until thickness or roughness of teat-end hyperkeratosis responded to the experimental liner. The investigations were done on two dairy farms, one in USA and one in Germany. A split-udder arrangement of liners was used, and control treatment was a liner with round barrel shape. The test period comprised 14 weeks in the first study and 16 weeks in the second study. Thickness of teat-end hyperkeratosis was influenced by farm and test week. Roughness was influenced by farm, test week and treatment. In the first study, the incidence of rough teat-end hyperkeratosis was about 28 and 42% lower in teats milked with the experimental liner than in teats milked with the control liner by test weeks 11 and 14, respectively. In the second study, incidence of rough teat-end hyperkeratosis was rare in general, and in addition hardly occurred in teats milked with the experimental liner. The results indicate that the barrel design of the experimental liner causes similar effects on different farms but magnitude of the effect depends on initial incidence of teat end hyperkeratosis in the herd. PMID:27210492

  4. The ATLAS Detector Control System

    NASA Astrophysics Data System (ADS)

    Lantzsch, K.; Arfaoui, S.; Franz, S.; Gutzwiller, O.; Schlenker, S.; Tsarouchas, C. A.; Mindur, B.; Hartert, J.; Zimmermann, S.; Talyshev, A.; Oliveira Damazio, D.; Poblaguev, A.; Braun, H.; Hirschbuehl, D.; Kersten, S.; Martin, T.; Thompson, P. D.; Caforio, D.; Sbarra, C.; Hoffmann, D.; Nemecek, S.; Robichaud-Veronneau, A.; Wynne, B.; Banas, E.; Hajduk, Z.; Olszowska, J.; Stanecka, E.; Bindi, M.; Polini, A.; Deliyergiyev, M.; Mandic, I.; Ertel, E.; Marques Vinagre, F.; Ribeiro, G.; Santos, H. F.; Barillari, T.; Habring, J.; Huber, J.; Arabidze, G.; Boterenbrood, H.; Hart, R.; Iakovidis, G.; Karakostas, K.; Leontsinis, S.; Mountricha, E.; Ntekas, K.; Filimonov, V.; Khomutnikov, V.; Kovalenko, S.; Grassi, V.; Mitrevski, J.; Phillips, P.; Chekulaev, S.; D'Auria, S.; Nagai, K.; Tartarelli, G. F.; Aielli, G.; Marchese, F.; Lafarguette, P.; Brenner, R.

    2012-12-01

    The ATLAS experiment is one of the multi-purpose experiments at the Large Hadron Collider (LHC) at CERN, constructed to study elementary particle interactions in collisions of high-energy proton beams. Twelve different sub detectors as well as the common experimental infrastructure are controlled and monitored by the Detector Control System (DCS) using a highly distributed system of 140 server machines running the industrial SCADA product PVSS. Higher level control system layers allow for automatic control procedures, efficient error recognition and handling, manage the communication with external systems such as the LHC controls, and provide a synchronization mechanism with the ATLAS data acquisition system. Different databases are used to store the online parameters of the experiment, replicate a subset used for physics reconstruction, and store the configuration parameters of the systems. This contribution describes the computing architecture and software tools to handle this complex and highly interconnected control system.

  5. ATLAS Live: Collaborative Information Streams

    NASA Astrophysics Data System (ADS)

    Goldfarb, Steven; ATLAS Collaboration

    2011-12-01

    I report on a pilot project launched in 2010 focusing on facilitating communication and information exchange within the ATLAS Collaboration, through the combination of digital signage software and webcasting. The project, called ATLAS Live, implements video streams of information, ranging from detailed detector and data status to educational and outreach material. The content, including text, images, video and audio, is collected, visualised and scheduled using digital signage software. The system is robust and flexible, utilizing scripts to input data from remote sources, such as the CERN Document Server, Indico, or any available URL, and to integrate these sources into professional-quality streams, including text scrolling, transition effects, inter and intra-screen divisibility. Information is published via the encoding and webcasting of standard video streams, viewable on all common platforms, using a web browser or other common video tool. Authorisation is enforced at the level of the streaming and at the web portals, using the CERN SSO system.

  6. The New European Wind Atlas

    NASA Astrophysics Data System (ADS)

    Lundtang Petersen, Erik

    2013-04-01

    The New European Wind Atlas 1. European wind resource assessment through a ERA-NET Plus project 1.1 The new EU Atlas The Commission decided earlier this year to issue an ERA-NET Plus call for the creation and publication of a new EU wind atlas. The atlas will cover Member states as well as Member states' exclusive economic zones, both onshore and offshore. It involved the launch of a single joint call for proposals by promoters of national and/or regional programmes, thereby allowing a more efficient use of existing financial resources. Therefore the funding scheme is that of ERA-NET Plus which implies that at least 5 MS shall commit at least 1 million Euros each and the Commission tops up with on third of the MS contribution. Basically it is the MS research programmes that will execute the project but an important part of the project is to create "open project development platforms" with associated protocols allowing a wider range of scientists worldwide to contribute. The project has a duration of 5 years. The decision on the new wind atlas was taken after several years of work by the European Wind Energy Technology Platform and the European Energy Research Alliances' Joint programme for Wind Energy. 2. Structure of the project The project will be structured around three areas of work, to be implemented in parallel: 2.1 Creation and publication of a European wind atlas in electronic form, which will include the underlying data and a new EU wind climate database. The database will at a minimum include: Wind resources and their associated uncertainty; Extreme wind; Turbulence characteristics; Adverse weather conditions; Predictability for short term prediction; Guidelines. 2.2 Development of dynamical downscaling methodologies and open-source models. The developed downscaling methodologies and models will be fully documented and made public available and will be used to produce overview maps of wind resources and relevant data at several heights and a horizontal

  7. The Copernicus ultraviolet spectral atlas of Sirius

    NASA Technical Reports Server (NTRS)

    Rogerson, John B., Jr.

    1987-01-01

    A near-ultraviolet spectral atlas for the A1 V star Alpha CMa (Sirius) has been prepared from data taken by the Princeton spectrometer aboard the Copernicus satellite. The spectral region from 1649 to 3170 A has been scanned with a resolution of 0.1 A. The atlas is presented in graphs, and line identifications for the absorption features have been tabulated.

  8. Learning with the ATLAS Experiment at CERN

    ERIC Educational Resources Information Center

    Barnett, R. M.; Johansson, K. E.; Kourkoumelis, C.; Long, L.; Pequenao, J.; Reimers, C.; Watkins, P.

    2012-01-01

    With the start of the LHC, the new particle collider at CERN, the ATLAS experiment is also providing high-energy particle collisions for educational purposes. Several education projects--education scenarios--have been developed and tested on students and teachers in several European countries within the Learning with ATLAS@CERN project. These…

  9. The New England solar energy atlas

    SciTech Connect

    Cook, D.L.

    1986-01-01

    This book offers a convenient source of historical solar radiation data excerpted from the Solar Radiation Energy Resource Atlas of the United States. The collection of regional maps and the graphic summaries of the resource data pertinent to the New England area accomplish the author's goal of providing design data in a more compact format than that of the national atlas.

  10. Onboard photo: STS-56 ATLAS-2

    NASA Technical Reports Server (NTRS)

    1993-01-01

    Space Shuttle Discovery (STS-56) onboard photo of Mission Specialist Michael Foale working in the Atmospheric Laboratory for Applications and Science (ATLAS-2). The ATLAS program was designed to measure the long term variability in the total energy radiated by the sun and determine the variability in the solar spectrum.

  11. STS-45 Atlas-1 Compiled Processing Footage

    NASA Technical Reports Server (NTRS)

    1992-01-01

    Compiled footage shows shots of the Atmospheric Laboratory for Applications and Science's (Atlas-1's) move to the test stand at the Operations and Checkout (O&C) Building, the sharp edge inspection, and the Atlas-1 press showing. The STS-45 Atlantis rollover to the Vehicle Assembly Building (VAB) and subsequent rollout to Pad A are seen.

  12. Onboard Photo : STS-45 Atlas-1

    NASA Technical Reports Server (NTRS)

    1992-01-01

    Space Shuttle Atlantis (STS-45) onboard photo of Mission Specialist Kathryn Sullivan working in the Atmospheric Laboratory for Applications and Science (Atlas-1) module. Atlas-1 flew in a series of Spacelab flights that measured long term variability in the total energy radiated by the Sun and determined the variability in the solar spectrum.

  13. Philippines Wind Energy Resource Atlas Development

    SciTech Connect

    Elliott, D.

    2000-11-29

    This paper describes the creation of a comprehensive wind energy resource atlas for the Philippines. The atlas was created to facilitate the rapid identification of good wind resource areas and understanding of the salient wind characteristics. Detailed wind resource maps were generated for the entire country using an advanced wind mapping technique and innovative assessment methods recently developed at the National Renewable Energy Laboratory.

  14. World Bank Atlas. [Twenty-Fourth Edition.

    ERIC Educational Resources Information Center

    World Bank, Washington, DC.

    This edition of the World Bank Atlas presents curent economic and social data for 185 countries and territories in the world. A number of maps, tables, and graphs highlight key relationships and trends in the development of the countries. The atlas includes data on population, gross national product (GNP), share of agriculture in gross domestic…

  15. Criteria for level 1 and level 2 trauma codes: Are pelvic ring injuries undertriaged?

    PubMed Central

    Haws, Brittany E; Wuertzer, Scott; Raffield, Laura; Lenchik, Leon; Miller, Anna N

    2016-01-01

    AIM To determine the association of unstable pelvic ring injuries with trauma code status. METHODS A retrospective review of all pelvic ring injuries at a single academic center from July 2010 to June 2013 was performed. The trauma registry was used to identify level 1 and level 2 trauma codes for each injury. The computed tomography scans in all patients were classified as stable or unstable using the Abbreviated Injury Scale. Pelvic injury classifications in level 1 and level 2 groups were compared. Patient disposition at discharge in level 1 and level 2 groups were also compared. RESULTS There were 108 level 1 and 130 level 2 blunt trauma admissions. In the level 1 group, 67% of pelvic injuries were classified as stable fracture patterns and 33% were classified as unstable. In the level 2 group, 62% of pelvic injuries were classified as stable fracture patterns and 38% were classified as unstable. level 1 trauma code was not associated with odds of having an unstable fracture pattern (OR = 0.83, 95%CI: 0.48-1.41, P = 0.485). In the level 1 group with unstable pelvic injuries, 33% were discharged to home, 36% to a rehabilitation facility, and 32% died. In the level 2 group with unstable pelvic injuries, 65% were discharged to home, 31% to a rehabilitation facility, and 4% died. For those with unstable pelvic fractures (n = 85), assignment of a level 2 trauma code was associated with reduced odds of death (OR = 0.07, 95%CI: 0.01-0.35, P = 0.001) as compared to being discharged to home. CONCLUSION Trauma code level assignment is not correlated with severity of pelvic injury. Because an unstable pelvis can lead to hemodynamic instability, these injuries may be undertriaged. PMID:27622148

  16. Overview of the Atlas project

    SciTech Connect

    Trainor, R.J.; Ballard, E.O.; Bartsch, R.R.

    1997-09-01

    Atlas is a high energy pulsed power facility under development at Los Alamos National Laboratory to perform high energy-density experiments in support of the Department of Energy`s stockpile stewardship responsibility. Its design is optimized for materials properties and hydrodynamics experiments under extreme conditions. Atlas will be operational in late-1999 and is designed to provide 100 shots per year. The Atlas capacitor bank design consists of a 36-MJ array of 240-kV Marx modules. The system is designed to deliver a peak current of 45--50 MA with a 4--5 {micro}s risetime. The Marx modules are designed to be reconfigured to a 480-kV configuration, if needed, for opening switch development. The bank is resistively damped to limit fault currents and capacitor voltage reversal. The system is configured for very low-inductance operation (total inductance {approximately} 10 nH) to rapidly implode heavy liner loads. An experimental program for testing and certifying prototype components is currently underway. For many applications the Atlas liner will be nominal 70g aluminum cylinder. Using composite inner layers and a variety of interior target designs, a wide variety of experiments in {approximately}cm{sup 3} volumes may be performed. These include shock compression experiments up to {approximately} 3 TPa (30 Mbar), quasi-adiabatic compressions up to 6-fold compression and pressures above 10 TPa, hydrodynamic instability studies in nonlinear and turbulent regimes over multi-cm propagation lengths, experiments with dense plasmas in the so-called high-gamma regime, studies of materials response at very high strains and strain rates, and materials studies in ultrahigh magnetic fields (above 10{sup 3} T).

  17. The ATLAS energy upgrade cryomodule.

    SciTech Connect

    Fuerst, J. D.; Physics

    2009-01-01

    A new cryomodule containing seven drift-tube-loaded quarter-wave resonant cavities has been added to the ATLAS heavy ion linac at Argonne National Laboratory. Initial operation with beam took place this summer. The module provided a stable 14.7 MV of accelerating potential (2.1 MV/cavity), a record for cavities at this beta. This paper describes cavity, cryomodule, and subsystem performance. A report on the final assembly, commissioning and operational experience is also given.

  18. Stuart R. Stidolph diatom atlas

    USGS Publications Warehouse

    Stidolph, S.R.; Sterrenburg, F.A.S.; Smith, K.E.L.; Kraberg, A.

    2012-01-01

    The "Stuart R. Stidolph Diatom Atlas" is a comprehensive volume of diatom taxa identified and micrographed by Stuart R. Stidoph during the 1980s and 1990s. The samples were collected from marine coasts of various geographic regions within tropical and subtropical climates. The plates included within this report have never been published and are being published by the USGS as an online reference so that others may have access to this incredible collection.

  19. ATLAS LAr calorimeter performance and LHC Run-2 commissioning

    NASA Astrophysics Data System (ADS)

    Spettel, Fabian

    2016-07-01

    The ATLAS detector was built to study proton-proton collisions produced by the Large Hadron Collider (LHC) at a center of mass energy of up to 14 TeV. The Liquid Argon (LAr) calorimeters are used for all electromagnetic calorimetry as well as the hadronic calorimetry in the endcap and forward regions. They have shown excellent performance during the first LHC data taking campaign, from 2010 to 2012, so-called Run 1, at a peak luminosity of 8 ×1033cm-2s-1. During the next run, peak luminosities of 1.5 ×1034cm-2s-1 and even higher are expected at a 25 ns bunch spacing. Such a high collision rate may have an impact on the quality of the energy reconstruction which is attempted to be maintained at a high level using a calibration procedure described in this contribution. It also poses major challenges to the first level of the trigger system which is constrained to a maximal rate of 100 kHz. For Run-3, scheduled to start in 2019, instantaneous luminosity as high as 3 ×1034cm-2s-1 are foreseen imposing an upgrade of the LAr trigger system to maintain its performance. A demonstrator containing prototypes of the upgraded trigger electronic architecture has been installed on one of the barrel electromagnetic calorimeter readout front end crates to test it during the Run-2 campaign. The new architecture and its benefits for data taking will be discussed below as well as the results from first beam splash events.

  20. Luminosity monitoring in ATLAS with MPX detectors

    NASA Astrophysics Data System (ADS)

    Sopczak, A.

    2014-01-01

    The ATLAS-MPX detectors are based on the Medipix2 silicon devices designed by CERN for the detection of multiple types of radiation. Sixteen such detectors were successfully operated in the ATLAS detector at the LHC and collected data independently of the ATLAS data-recording chain from 2008 to 2013. Each ATLAS-MPX detector provides separate measurements of the bunch-integrated LHC luminosity. An internal consistency for luminosity monitoring of about 2% was demonstrated. In addition, the MPX devices close to the beam are sensitive enough to provide relative-luminosity measurements during van der Meer calibration scans, in a low-luminosity regime that lies below the sensitivity of the ATLAS calorimeter-based bunch-integrating luminometers. Preliminary results from these luminosity studies are presented for 2012 data taken at √s = 8 TeV proton-proton collisions.

  1. Luminosity Monitoring in ATLAS with MPX Detectors

    NASA Astrophysics Data System (ADS)

    Asbah, Nedaa

    2014-06-01

    The ATLAS-MPX detectors are based on the Medipix2 silicon devices designed by CERN for the detection of multiple types of radiation. Sixteen such detectors were successfully operated in the ATLAS detector at the LHC and collected data independently of the ATLAS data-recording chain from 2008 to 2013. Each ATLAS-MPX detector provides separate measurements of the bunch-integrated LHC luminosity. An internal consistency for luminosity monitoring of about 2% was demonstrated. In addition, the MPX devices close to the beam are sensitive enough to provide relative-luminosity measurements during van der Meer calibration scans, in a low-luminosity regime that lies below the sensitivity of the ATLAS calorimeter-based bunch-integrating luminometers. Preliminary results from these luminosity studies are presented for 2012 data taken at √ s = 8 TeV proton-proton collisions.

  2. The ATLAS All-Sky Survey

    NASA Astrophysics Data System (ADS)

    Denneau, L.

    The Asteroid Terrestrial-impact Last Alert System (ATLAS) is a small project with an ambitious goal: early warning of asteroid impacts on Earth. We aim to provide one day warning for the smallest "town-killer" 30-kiloton asteroids up to three weeks for a 100-megaton impactor. ATLAS will execute a wide-field all-sky survey with four visits per footprint per night down to a sensitivity limit of V=20, suitable for detection dangerous asteroids and enabling other exciting time-domain astronomy. ATLAS is currently under construction and expects to be fully operational in late 2015. We provide an overview of the ATLAS system and discuss how ATLAS can participate in the emerging community of time-domain astronomy.

  3. Renewable Energy Atlas of the United States

    SciTech Connect

    Kuiper, J.; Hlava, K.; Greenwood, H.; Carr, A.

    2013-12-13

    The Renewable Energy Atlas (Atlas) of the United States is a compilation of geospatial data focused on renewable energy resources, federal land ownership, and base map reference information. This report explains how to add the Atlas to your computer and install the associated software. The report also includes: A description of each of the components of the Atlas; Lists of the Geographic Information System (GIS) database content and sources; and A brief introduction to the major renewable energy technologies. The Atlas includes the following: A GIS database organized as a set of Environmental Systems Research Institute (ESRI) ArcGIS Personal GeoDatabases, and ESRI ArcReader and ArcGIS project files providing an interactive map visualization and analysis interface.

  4. Summary of types of radiation belt electron precipitation observed by BARREL

    NASA Astrophysics Data System (ADS)

    Halford, Alexa

    2016-07-01

    The Balloon Array for Relativistic Radiation belt Electron Loss (BARREL) was able to infer precipitation of radiation belt electrons on multiple time scales and due to multiple loss mechanisms. One storm will be specifically highlighted which occurred on 26 January 2013 when a solar wind shock hit the Earth. Although MeV electrons were observed to be lost due to an EMIC wave event [Zhang et al in prep], and multiple periods of electron loss during substorms were observed [Rae et al submitted JGR, Mann et al in prep], we will consider an event period where loss associated with multiple time scales, and thus possibly different loss mechanisms was observed from 1000 - 1200 UT on 26 January 2013. At about 1005 UT on 26 January 2013 an injection of radiation belt electrons followed by drift echoes for energies of ˜80 - 400 keV. BARREL observed X-rays with energies less than 180 keV associated with multiple temporal structures during the drift echo event period. The Van Allen Probes were at similar L-values but upwards of 2 hours away in MLT. Upper band chorus and ULF waves were observed during the event period. Throughout the beginning of the event period, microbursts were clearly observed. During this time lower band chorus waves as well as time domain structures were observed at Van Allen Probe A located upwards of 2 hours away in MLT. This large difference in MLT meant that neither potential loss mechanism was able to be clearly associated with the microbursts. As the lower band chorus and time domain structures were observed to recede, the microbursts were also observed to subside. ULF time scale modulation of the X-rays was also observed throughout most of the event period. We will examine if the ULF waves are the cause of the precipitation themselves, or are modulating the loss of particles from a secondary loss mechanism [Brito et al 2015 JGR, Rae et al Submitted JGR]. Although the 100s ms and ULF time scales are clearly observed, there is an ˜20 minute

  5. Atlas-based identification of cortical sulci

    NASA Astrophysics Data System (ADS)

    Nowinski, Wieslaw L.; Raphel, Jose K.; Nguyen, Bonnie T.

    1996-04-01

    The identification of cortical sulci is of great importance. In neurosurgical procedures any target in the cranium can be accessed by following the corridors of the sulci and fissures. The fusion of functional and anatomical data also requires the identification of sulci. Several approaches have been proposed for segmentation of the cortical surface and identification of sulci and fissures. Most of them are bottom-up. They work satisfactorily provided that the sulci are well discernible on MRI images, limiting their use to some major sulci and fissures, such as the central sulcus, interhemispheric fissure, or Sylvian fissure. We propose a sulcal model based approach, overcoming some of the above limitations. The sulcal model is derived from two brain atlases: Co-Planar Stereotaxic Atlas of the Human Brain by Talairach- Tournoux (TT), and Atlas of Cerebral Sulci by Ono-Kubik-Abernathey (OKA). The OKA atlas contains 403 patterns for 55 sulci along with their incidence rates of interruptions, side branches, and connections. An electronic version of the OKA atlas was constructed, quantitatively enhanced by placing the sulcal patterns in a stereotactic space. The original patterns from the OKA atlas were digitized, converted into geometric representation, placed in the Talairach stereotactic space, preregistered with the TT atlas, and integrated with a multi- atlas, multi-dimensional neuroimaging system developed by our group. The registration of any atlas with the clinical data automatically registers all atlases with this data. This way the sulcal patterns can be superimposed on data, indicating approximate locations of sulci on images. The approach proposed here provides a simple and real-time registration of the sulcal patterns with clinical data, and an interactive identification and labeling of sulci. This approach assists rather the medical professional, instead of providing a complete automated extraction of a few, primary sulci with certain accuracy, where a

  6. Lipid Bilayer-Bound Conformation of an Integral Membrane Beta Barrel Protein by Multidimensional MAS NMR

    PubMed Central

    Eddy, Matthew T.; Su, Yongchao; Silvers, Robert; Andreas, Loren; Clark, Lindsay; Wagner, Gerhard; Pintacuda, Guido; Emsley, Lyndon; Griffin, Robert G.

    2015-01-01

    The human voltage dependent anion channel 1 (VDAC) is a 32 kDa β-barrel integral membrane protein that controls the transport of ions across the outer mitochondrial membrane. Despite the determination of VDAC solution and diffraction structures, a structural basis for the mechanism of its function is not yet fully understood. Biophysical studies suggest VDAC requires a lipid bilayer to achieve full function, motivating the need for atomic resolution structural information of VDAC in a membrane environment. Here we report an essential step toward that goal: extensive assignments of backbone and side chain resonances for VDAC in DMPC lipid bilayers via magic angle spinning nuclear magnetic resonance (MAS NMR). VDAC reconstituted into DMPC lipid bilayers spontaneously forms 2-dimensional lipid crystals, showing remarkable spectral resolution (0.5–0.3 ppm for 13C line width and less than 0.5 ppm 15N line widths at 750 MHz). In addition to the benefits of working in a lipid bilayer, several distinct advantages are observed with the lipid crystalline preparation. First, the strong signals and sharp line widths facilitated extensive NMR resonance assignments for an integral membrane β-barrel protein in lipid bilayers by MAS NMR. Second, a large number of residues in loop regions were readily observed and assigned, which can be challenging in detergent-solubilized membrane proteins where loop regions are often not detected due to line broadening from conformational exchange. Third, complete backbone and side chain chemical shift assignments could be obtained for the first 25 residues, which comprise the functionally important N-terminus. The reported assignments allow us to compare predicted torsion angles for VDAC prepared in DMPC 2D lipid crystals, DMPC liposomes, and LDAO-solubilized samples to address the possible effects of the membrane mimetic environment on the conformation of the protein. Concluding, we discuss the strengths and weaknesses of the reported

  7. Lipid bilayer-bound conformation of an integral membrane beta barrel protein by multidimensional MAS NMR.

    PubMed

    Eddy, Matthew T; Su, Yongchao; Silvers, Robert; Andreas, Loren; Clark, Lindsay; Wagner, Gerhard; Pintacuda, Guido; Emsley, Lyndon; Griffin, Robert G

    2015-04-01

    The human voltage dependent anion channel 1 (VDAC) is a 32 kDa β-barrel integral membrane protein that controls the transport of ions across the outer mitochondrial membrane. Despite the determination of VDAC solution and diffraction structures, a structural basis for the mechanism of its function is not yet fully understood. Biophysical studies suggest VDAC requires a lipid bilayer to achieve full function, motivating the need for atomic resolution structural information of VDAC in a membrane environment. Here we report an essential step toward that goal: extensive assignments of backbone and side chain resonances for VDAC in DMPC lipid bilayers via magic angle spinning nuclear magnetic resonance (MAS NMR). VDAC reconstituted into DMPC lipid bilayers spontaneously forms two-dimensional lipid crystals, showing remarkable spectral resolution (0.5-0.3 ppm for (13)C line widths and <0.5 ppm (15)N line widths at 750 MHz). In addition to the benefits of working in a lipid bilayer, several distinct advantages are observed with the lipid crystalline preparation. First, the strong signals and sharp line widths facilitated extensive NMR resonance assignments for an integral membrane β-barrel protein in lipid bilayers by MAS NMR. Second, a large number of residues in loop regions were readily observed and assigned, which can be challenging in detergent-solubilized membrane proteins where loop regions are often not detected due to line broadening from conformational exchange. Third, complete backbone and side chain chemical shift assignments could be obtained for the first 25 residues, which comprise the functionally important N-terminus. The reported assignments allow us to compare predicted torsion angles for VDAC prepared in DMPC 2D lipid crystals, DMPC liposomes, and LDAO-solubilized samples to address the possible effects of the membrane mimetic environment on the conformation of the protein. Concluding, we discuss the strengths and weaknesses of the reported

  8. LASCO C2 and C3 Level-1 Images: Calibration and Pipeline Processing

    NASA Astrophysics Data System (ADS)

    Thernisien, A. F.; Morrill, J.; Llebaria, A.; Rich, N.; Vourlidas, A.; Esfandiari, E.; Wang, D.; Korendyke, C.; Moses, D.; Biesecker, D.; Bout, M.; Lamy, P.; Howard, R. A.

    2003-12-01

    The LASCO C2 and C3 coronagraphs have provided coronal observations since May, 1996. Initial calibrations have been available during most of this time period. We have subsequently completed a re-evaluation and refinement of these calibration procedures. We are now able to present the final version of the level-1 data using the latest improvements from in-flight calibration results. Further details on the LASCO calibration and level-1 data access are presented at http://lasco-www.nrl.navy.mil/level_1/lascocal_index.html. In this presentation we will sum up the different aspects of the LASCO C2-C3 image corrections such as vignetting, absolute photometry, time corrections, geometric distortion, sun center position, and spacecraft orientation.

  9. Space Telecommunications Radio System (STRS) Architecture Goals/Objectives and Level 1 Requirements

    NASA Technical Reports Server (NTRS)

    Briones, Janette C.; Johnson, Sandra K.; VanDerAar, Lisa

    2007-01-01

    The Space Telecommunications Radio System (STRS) Architecture Requirements Document provides the basis for the development of an open architecture for NASA Software Defined Radios (SDRs) for space use. The main objective of this document is to evaluate the goals and objectives and high level (Level 1) requirements that have bearing on the design of the architecture. The goals and objectives will provide broad, fundamental direction and purpose. The high level requirements (Level 1) intend to guide the broader and longer term aspects aspects of the SDR Architecture and provide guidance for the development of level 2 requirements.

  10. Data flow analysis of a highly parallel processor for a level 1 pixel trigger

    SciTech Connect

    Cancelo, G.; Gottschalk, Erik Edward; Pavlicek, V.; Wang, M.; Wu, J.

    2003-01-01

    The present work describes the architecture and data flow analysis of a highly parallel processor for the Level 1 Pixel Trigger for the BTeV experiment at Fermilab. First the Level 1 Trigger system is described. Then the major components are analyzed by resorting to mathematical modeling. Also, behavioral simulations are used to confirm the models. Results from modeling and simulations are fed back into the system in order to improve the architecture, eliminate bottlenecks, allocate sufficient buffering between processes and obtain other important design parameters. An interesting feature of the current analysis is that the models can be extended to a large class of architectures and parallel systems.

  11. Cross‐species chimeras reveal BamA POTRA and β‐barrel domains must be fine‐tuned for efficient OMP insertion

    PubMed Central

    Bavro, Vassiliy N.; Mason, Jessica L.; Sevastsyanovich, Yanina R.; Rossiter, Amanda E.; Jeeves, Mark; Wells, Timothy J.; Knowles, Timothy J.; Cunningham, Adam F.; Donald, James W.; Palmer, Tracy; Overduin, Michael

    2015-01-01

    Summary BAM is a conserved molecular machine, the central component of which is BamA. Orthologues of BamA are found in all Gram‐negative bacteria, chloroplasts and mitochondria where it is required for the folding and insertion of β‐barrel containing integral outer membrane proteins (OMPs) into the outer membrane. BamA binds unfolded β‐barrel precursors via the five polypeptide transport‐associated (POTRA) domains at its N‐terminus. The C‐terminus of BamA folds into a β‐barrel domain, which tethers BamA to the outer membrane and is involved in OMP insertion. BamA orthologues are found in all Gram‐negative bacteria and appear to function in a species‐specific manner. Here we investigate the nature of this species‐specificity by examining whether chimeric E scherichia coli  BamA fusion proteins, carrying either the β‐barrel or POTRA domains from various BamA orthologues, can functionally replace E . coli  BamA. We demonstrate that the β‐barrel domains of many BamA orthologues are functionally interchangeable. We show that defects in the orthologous POTRA domains can be rescued by compensatory mutations within the β‐barrel. These data reveal that the POTRA and barrel domains must be precisely aligned to ensure efficient OMP insertion. PMID:25943387

  12. Oral creatine supplementation on performance of Quarter Horses used in barrel racing.

    PubMed

    Teixeira, F A; Araújo, A L; Ramalho, L O; Adamkosky, M S; Lacerda, T F; Coelho, C S

    2016-06-01

    The aim of this study was to evaluate the effects of oral creatine supplementation on the athletic performance of equines used for barrel racing. Ten healthy Quarter Horses, or Quarter Horse crossbred, weighing 429.7 ± 25.3 kg and with mean age of 3.8 ± 1.2 years, were used. Animals were evaluated in four different moments (M1, M2, M3, M4), and between M3 and M4, they were supplemented with 28 g of creatine/100 kg of body weight, orally, for 45 days. Although significant alterations for LDH activity, plasma glucose and packed cell volume were observed, it was possible to conclude that there was no improvement in the athletic performance for the animals used on the experiment, as there were no changes in time scores, heart rate and plasma lactate, variables considered as performance indicators, before and after supplementation. PMID:26613801

  13. Systolic architectures based on barrel shifters for real-time digital signal processing

    SciTech Connect

    Chen, T.

    1985-01-01

    The throughput in real-time digital signal processing applications is limited by both the capability of the processors employed for number-crunching operations and the capacity of a supporting communications link. The systolic architectures eliminate the memory bandwidth problems by allowing multiple computations for each memory access and result in a speed-up in the execution time of compute-bound computations. However, the throughput rate in a systolic array is still limited by the computational time needed for one basic cell, which is composed of a multiplier and an accumulator. The multiplier in the basic cell requires either a large chip area if high speed is desired, or a large amount of time if serial architecture is used. The use of barrel shifters as computational elements in systolic arrays was proposed and studied in detail in this thesis. In the new systolic arrays there are two different structures, parallel and cascaded, that can be used to implement FIR filters. A unique cascaded structure was developed in this study that is shown to have better performance and requires significantly less basic cells.

  14. A lipoprotein/β-barrel complex monitors lipopolysaccharide integrity transducing information across the outer membrane

    PubMed Central

    Konovalova, Anna; Mitchell, Angela M; Silhavy, Thomas J

    2016-01-01

    Lipoprotein RcsF is the OM component of the Rcs envelope stress response. RcsF exists in complexes with β-barrel proteins (OMPs) allowing it to adopt a transmembrane orientation with a lipidated N-terminal domain on the cell surface and a periplasmic C-terminal domain. Here we report that mutations that remove BamE or alter a residue in the RcsF trans-lumen domain specifically prevent assembly of the interlocked complexes without inactivating either RcsF or the OMP. Using these mutations we demonstrate that these RcsF/OMP complexes are required for sensing OM outer leaflet stress. Using mutations that alter the positively charged surface-exposed domain, we show that RcsF monitors lateral interactions between lipopolysaccharide (LPS) molecules. When these interactions are disrupted by cationic antimicrobial peptides, or by the loss of negatively charged phosphate groups on the LPS molecule, this information is transduced to the RcsF C-terminal signaling domain located in the periplasm to activate the stress response. DOI: http://dx.doi.org/10.7554/eLife.15276.001 PMID:27282389

  15. A lipoprotein/β-barrel complex monitors lipopolysaccharide integrity transducing information across the outer membrane.

    PubMed

    Konovalova, Anna; Mitchell, Angela M; Silhavy, Thomas J

    2016-01-01

    Lipoprotein RcsF is the OM component of the Rcs envelope stress response. RcsF exists in complexes with β-barrel proteins (OMPs) allowing it to adopt a transmembrane orientation with a lipidated N-terminal domain on the cell surface and a periplasmic C-terminal domain. Here we report that mutations that remove BamE or alter a residue in the RcsF trans-lumen domain specifically prevent assembly of the interlocked complexes without inactivating either RcsF or the OMP. Using these mutations we demonstrate that these RcsF/OMP complexes are required for sensing OM outer leaflet stress. Using mutations that alter the positively charged surface-exposed domain, we show that RcsF monitors lateral interactions between lipopolysaccharide (LPS) molecules. When these interactions are disrupted by cationic antimicrobial peptides, or by the loss of negatively charged phosphate groups on the LPS molecule, this information is transduced to the RcsF C-terminal signaling domain located in the periplasm to activate the stress response. PMID:27282389

  16. Detergent-associated Solution Conformations of Helical and Beta-barrel Membrane Proteins

    SciTech Connect

    Mo, Yiming; Lee, Byung-Kwon; Ankner, John Francis; Becker, Jeffrey Marvin; Heller, William T

    2008-01-01

    Membrane proteins present major challenges for structural biology. In particular, the production of suitable crystals for high-resolution structural determination continues to be a significant roadblock for developing an atomic-level understanding of these vital cellular systems. The use of detergents for extracting membrane proteins from the native membrane for either crystallization or reconstitution into model lipid membranes for further study is assumed to leave the protein with the proper fold with a belt of detergent encompassing the membrane-spanning segments of the structure. Small-angle X-ray scattering was used to probe the detergent-associated solution conformations of three membrane proteins, namely bacteriorhodopsin (BR), the Ste2p G-protein coupled receptor from Saccharomyces cerevisiae, and the Escherichia coli porin OmpF. The results demonstrate that, contrary to the traditional model of a detergent-associated membrane protein, the helical proteins BR and Ste2p are not in the expected, compact conformation and associated with detergent micelles, while the ?-barrel OmpF is indeed embedded in a disk-like micelle in a properly folded state. The comparison provided by the BR and Ste2p, both members of the 7TM family of helical membrane proteins, further suggests that the interhelical interactions between the transmembrane helices of the two proteins differ, such that BR, like other rhodopsins, can properly refold to crystallize, while Ste2p continues to prove resistant to crystallization from an initially detergent-associated state.

  17. Barrel time-of-flight detector for the PANDA experiment at FAIR

    NASA Astrophysics Data System (ADS)

    Gruber, L.; Brunner, S. E.; Marton, J.; Orth, H.; Suzuki, K.

    2016-07-01

    The barrel time-of-flight detector for the PANDA experiment at FAIR is foreseen as a Scintillator Tile (SciTil) Hodoscope based on several thousand small plastic scintillator tiles read-out with directly attached Silicon Photomultipliers (SiPMs). The main tasks of the system are an accurate determination of the time origin of particle tracks to avoid event mixing at high collision rates, relative time-of-flight measurements as well as particle identification in the low momentum regime. The main requirements are the use of a minimum material amount and a time resolution of σ < 100 ps. We have performed extensive optimization studies and prototype tests to prove the feasibility of the SciTil design and finalize the R&D phase. In a 2.7 GeV/c proton beam at Forschungszentrum Jülich a time resolution of about 80 ps has been achieved using SiPMs from KETEK and Hamamatsu with an active area of 3 × 3mm2. Employing the Digital Photon Counter from Philips a time resolution of about 30 ps has been reached.

  18. [Testing Research of Transient Temperature Distribution for the Barrel Surface by Speckle Pattern Interferometry].

    PubMed

    Lang, Wen-jie; Chen, Guo-guang; Tian, Xiao-li; Xin, Chang-fan

    2016-02-01

    There are some problems in the traditional transient temperature test equipment. The thermal inertia is great, and can only be a single point of detection. To be able to achieve real-time monitoring for transient temperature distribution change of the gun body surface, the test system for transient temperature distribution was designed based on Speckle Pattern Interferometry (SPI) and spectroscopy. In the system, transient temperature change of the barrel led to slight deformation, and it was converted into speckle interference fringes by SPI technology. Spectral distribution function was obtained by the interference fringes by the Fourier transform, so the information of interference fringe deformation was incorporated into the frequency domain. The data of temperature distribution can be inverted on any sampling time by spectral distribution function. In experiments, the ZX-FB1 fiber optic thermometer was used to test transient temperature on a single point as the standard value. The center wavelength of the laser was 555 nm, and the speckle pattern interference fringes were collected by area array CCD. Image Recognition-Speckle Pattern Interferometry (IR-SPI) and Fourier Transform-Speckle Pattern Interferometry (FT-SPI) were used in experiments, the calculation of transient temperature was completed through two methods. Experimental results are that both methods can achieve transient temperature detection. But the FT-SPI is higher in terms of accuracy, and it can effectively overcome the gross error caused by the surface defects, paint wear and other similar problems. PMID:27209730

  19. Barrel-shaped ClpP Proteases Display Attenuated Cleavage Specificities.

    PubMed

    Gersch, Malte; Stahl, Matthias; Poreba, Marcin; Dahmen, Maria; Dziedzic, Anna; Drag, Marcin; Sieber, Stephan A

    2016-02-19

    ClpP is a self-compartmentalizing protease with crucial roles in bacterial and mitochondrial protein quality control. Although the ClpP homocomplex is composed of 14 equivalent active sites, it degrades a multitude of substrates to small peptides, demonstrating its capability to carry out diverse cleavage reactions. Here, we show that ClpP proteases from E. coli, S. aureus, and human mitochondria exhibit preferences for certain amino acids in the P1, P2, and P3 positions using a tailored fluorogenic substrate library. However, this high specificity is not retained during proteolysis of endogenous substrates as shown by mass spectrometric analysis of peptides produced in ClpXP-mediated degradation reactions. Our data suggest a mechanism that implicates the barrel-shaped architecture of ClpP not only in shielding the active sites to prevent uncontrolled proteolysis but also in providing high local substrate concentrations to enable efficient proteolytic processing. Furthermore, we introduce customized fluorogenic substrates with unnatural amino acids that greatly surpass the sensitivity of previously used tools. We used these to profile the activity of cancer-patient- and Perrault-syndrome-derived ClpP mutant proteins. PMID:26606371

  20. [The guiacum barrels between science and esoterism: Tommaso Campailla genius loci].

    PubMed

    Buscemi, Maria

    2007-01-01

    Tommaso Campailla, as a typical man of his time, had a good humanistic and scientific education. He was born in Modica in 1668 [corrected] from an aristocratic family. When he was sixteen years old he moved to Catania to study law, but in a short time he came back to his native town where he preferred to study as an autodidact. He got married and had children and was elected senator seven times. In spite of his particular look, he was appreciated for his vast culture and his great sensibility. Giovanna Finocchiaro Chimirri noticed his very kind soul and called him: "the christian and Italian Lucretio". In addition, he was a friend of the Arcadian poet Girolama Lorefice Grimaldi. Campailla was a very good medical doctor, although he was an autodidact, and he was very able to inculcate love for medical studies in many students. He fought syphilis rheumatism in a "modern" way, using the "guaiacum barrels" or "vapour stovens" that he had invented. He died in 1740 in Modica. PMID:18450036