Science.gov

Sample records for avada eli vaatlejate

  1. Drotrecogin alfa Eli Lilly.

    PubMed

    de Jonge, E

    2002-04-01

    Drotrecogin alfa (Xigris, recombinant activated protein C) is an anticoagulant developed and launched by Eli Lilly & Co for the treatment of sepsis [333781], [339372], [430133], [436271]. The FDA and the EMEA accepted the brand name Xigris for drotrecogin alfa in June 2001. This trade name had been proposed by Lilly in place of the previous brand name, Zovant, which was deemed unacceptable by the EMEA due to concerns that the name could be confused with hospital-based drugs [412512]. Filings for sepsis were made in the US, EU and Australia in February 2001 [398514], [447870] and in March 2001, the US FDA assigned drotrecogin alfa Priority Review status [403435]. The FDA extended the action date from July 27 to October 27, 2001 for completion of its review of the biologics license application (BLA) for drotrecogin alfa to assess further supplementary data submitted by Lilly [412512]. At the October 16, 2001 meeting (postponed from September 12), the FDA Advisory Committee on Anti-Infective Drugs split 10 to 10 over whether to recommend approval [425873], [425940]. In late October 2001, Lilly received an approvable letter from the FDA for the treatment of severe sepsis. Approval was contingent upon successful negotiation of labeling, agreement on post-approval clinical trials, and successful completion of manufacturing inspections [427301]. In November 2001, the FDA approved drotrecogin alfa for the reduction of mortality in adult patients with severe sepsis who have a high risk of death [430133]; the product was launched onto the US market days later [436271]. Following the FDA committee's split decision in October 2001, Credit Suisse First Boston, which expected mid-2002 approval but with restrictive labeling, revised its predictions from $1.265 billion in 2004 sharply downwards to $543 million [425929]. PMID:15565519

  2. Pemetrexed disodium (Eli Lilly).

    PubMed

    Norman, P

    2001-11-01

    Pemetrexed, a thymidylate synthase (TS) and transferase inhibitor, is in phase III trials with Eli Lilly as a potential treatment for several common solid tumors, including non-small cell lung cancer (NSCLC) and mesothelioma [321789], [410731]. Studies on pemetrexed have concluded that not only is the compound a TS inhibitor but also a potent inhibitor of human dihydrofolate reductase (DHFR). The results suggest that pemetrexed acts upon multiple intracellular targets and that the antitumor effect may be derived from its simultaneous inhibition of multiple folate-requiring enzymes [203662]: this compound has been designated as a multitargeted antifolate (MTA) [386680]. The drug also causes concentration- and time-dependent apoptosis [284380]. Other studies in which the 4-oxo group of the pyrimidine ring portion of pemetrexed was replaced with a hydrogen atom, demonstrated that the resulting analogs were potent DHFR inhibitors with very little activity against the enzymes glycinamide ribonucleotide formyltransferase (GARFT) and TS [310674]. In phase II European studies in 64 patients with advanced breast cancer, encouraging responses were seen in anthracycline-failure (23%) and anthracycline-refractory (19%) patients. Responses were observed in 28% of patients who had been previously treated with a taxane [326097]. Data from a phase II trial of pemetrexed (500 mg/m2 once every 21 days as a 10 min i.v. infusion) as a salvage therapy in advanced breast cancer showed that supplementation of the treatment regime with folic acid (FA) and vitamin B12 reduced its already manageable and tolerable toxicities [408821], [409650]. At doses of 500 mg/m2, the drug was also safely administered to 35 patients with impaired renal function [409953]. Phase I and II trials have shown that the main side effects include neutropenia, thrombocytopenia, mucositis, nausea and vomiting [203666], [272241]. Princeton University holds the patent rights to this drug under EP-00432677. In June

  3. 78 FR 49723 - Humboldt-Toiyabe National Forests; Ely Ranger District; Ely Westside Rangeland Project

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-15

    ... Forest Service Humboldt-Toiyabe National Forests; Ely Ranger District; Ely Westside Rangeland Project... of the Ely Westside Rangeland Project began in 2006 with the original Notice of Intent published in... and conditions) on the allotments in the Ely Westside Rangeland Project area. The objection...

  4. "ELI"--The Educational Futures Game.

    ERIC Educational Resources Information Center

    Mahoney, V. L. Mike; Grantham, Lex

    This report describes ELI, a computer-based educational game that gives participants, as citizens of fictitious cities, the opportunity to examine a variety of typical community issues relating to education within the context of broader city and regional problems. After a brief introduction, the game structure is described, including the setting…

  5. Gamma beam system at ELI-NP

    SciTech Connect

    Ur, Calin Alexandru

    2015-02-24

    The Gamma Beam System of ELI-NP will produce brilliant, quasi-monochromatic gamma-ray beams via Inverse Compton Scattering of short laser pulses on relativistic electron beam pulses. The scattered radiation is Doppler upshifted by more than 1,000,000 times and is forward focused in a narrow, polarized, tunable, laser-like beam. The gamma-ray beam at ELI-NP will be characterized by large spectral density of about 10{sup 4} photons/s/eV, narrow bandwidth (< 0.5%) and tunable energy from 200 keV up to about 20 MeV. The Gamma Beam System is a state-of-the-art equipment employing techniques and technologies at the limits of the present-day's knowledge.

  6. Electronic Lab Information Exchange (ELIE) in Saudi Arabia.

    PubMed

    Al Saleem, Nouf; El Metwally, Ashraf; Househ, Mowafa

    2014-01-01

    The purpose of this paper is to discuss the Saudi experience in implementing Electronic Lab Information Exchange (ELIE) within healthcare organizations in Saudi Arabia. This paper reviews the benefits, challenges and achievements that Saudi Arabia has gone through over the last five years in implementing ELIE. Data sources included academic literature, websites, and informant interviews. Results show that various Saudi healthcare organizations are participating in ELIE and improvements in laboratory department workflow and patient care have been reported. Future work includes projects to be implemented in different laboratories within the Kingdom to link the various laboratory information systems to Electronic Health Records. Various challenges stand in the way of implementing ELIE including weakness of the information infrastructure, staff resistance, recruiting qualified staff to develop and implement ELIE, producing clear policy and procedures to ensure staff compliance with the data entry, ensuring the privacy and integrity of patient data, and the lack of awareness on the importance of ELIE. PMID:25000034

  7. Elie Metchnikoff, the Man and the Myth.

    PubMed

    Gordon, Siamon

    2016-01-01

    The year 2016 marks the centenary of the death of Elie Metchnikoff, the father of innate immunity and discoverer of the significance of phagocytosis in development, homeostasis and disease. Through a series of intravital experiments on invertebrates and vertebrates, he described the role of specialised phagocytic cells, macrophages and microphages, subsequently renamed neutrophils and polymorphonuclear leucocytes, in the host response to injury, inflammation, infection and tissue repair. As a vigorous proponent of cellular immunity, he championed its importance versus humoral immunity in the so-called antibody wars. By 1908, when the Nobel Prize was awarded to Elie Metchnikoff and Paul Ehrlich, this debate was not yet resolved. Even earlier, Metchnikoff had turned his research interests to the process of ageing and the possible link to intestinal auto-intoxication, giving rise to the current interest in the microbiome of the gut and the use of probiotics to promote health and longevity. During the past century, Metchnikoff's reputation has waxed and waned, as lymphocyte heterogeneity, specificity and memory began to dominate the field of adaptive immunity, yet his benign visage continues to provide an iconic presence for specialists in innate immunology, whose studies have made a striking comeback in the past decade. In this review, I shall consider the nature of his studies and the person as well as the legendary description of his Eureka experience in Messina in 1882, a story loved by students and investigators alike, that marked, in his own words, his transformation from zoologist to pathologist. PMID:26836137

  8. 76 FR 53898 - Proposed Administrative Settlement Agreement and Order on Consent; In Re: Ely Copper Mine...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-30

    ... AGENCY Proposed Administrative Settlement Agreement and Order on Consent; In Re: Ely Copper Mine... concerning the Ely Copper Mine Superfund Site in Vershire, Vermont with the following settling party: Ely... e-mail at gardner.ann@epa.gov . Additional information on the Ely Copper Mine Superfund Site can...

  9. 52. GENERAL VIEW OF ELI WINDMILL ON STEEL TOWER IN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    52. GENERAL VIEW OF ELI WINDMILL ON STEEL TOWER IN PASTURE LOCATED ABOUT 6-8 MILES SOUTH OF NEBRASKA CITY ABOUT ONE 1 MILE WEST OF NEBRASKA HIGHWAY 75. - Kregel Windmill Company Factory, 1416 Central Avenue, Nebraska City, Otoe County, NE

  10. Assessing Eli Broad's Assault on Public School System Leadership

    ERIC Educational Resources Information Center

    English, Fenwick W.; Crowder, Zan

    2012-01-01

    Eli Broad's approach to reforming urban public education does not recognize his own self-interest in promoting changes within such educational systems, a classic problem of misrecognition. The Broad agenda is an assault on the notion of the mission of public education as a service instead of a for-profit enterprise concerned with making money for…

  11. 1. Historic American Buildings Survey Eli Lilly Company Photographic Department ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Eli Lilly Company Photographic Department - About 1937-1938 Gift courtesy of Edward D. James, FAIA, Preservation Officer GENERAL VIEW OF TRADING POST (LEFT) AND CABIN OF WILLIAM CONNER (RIGHT) AFTER RESTORATION - William Conner Trading Post, State Highway 234, Noblesville, Hamilton County, IN

  12. Extreme Light Infrastructure - Nuclear Physics Eli-Np Project

    NASA Astrophysics Data System (ADS)

    Gales, S.

    2015-06-01

    The development of high power lasers and the combination of such novel devices with accelerator technology has enlarged the science reach of many research fields, in particular High energy, Nuclear and Astrophysics as well as societal applications in Material Science, Nuclear Energy and Medicine. The European Strategic Forum for Research Infrastructures (ESFRI) has selected a proposal based on these new premises called "ELI" for Extreme Light Infrastructure. ELI will be built as a network of three complementary pillars at the frontier of laser technologies. The ELI-NP pillar (NP for Nuclear Physics) is under construction near Bucharest (Romania) and will develop a scientific program using two 10 PW class lasers and a Back Compton Scattering High Brilliance and Intense Low Energy Gamma Beam , a marriage of Laser and Accelerator technology at the frontier of knowledge. In the present paper, the technical description of the facility, the present status of the project as well as the science, applications and future perspectives will be discussed.

  13. Perspectives for photonuclear research at the Extreme Light Infrastructure - Nuclear Physics (ELI-NP) facility

    NASA Astrophysics Data System (ADS)

    Filipescu, D.; Anzalone, A.; Balabanski, D. L.; Belyshev, S. S.; Camera, F.; La Cognata, M.; Constantin, P.; Csige, L.; Cuong, P. V.; Cwiok, M.; Derya, V.; Dominik, W.; Gai, M.; Gales, S.; Gheorghe, I.; Ishkhanov, B. S.; Krasznahorkay, A.; Kuznetsov, A. A.; Mazzocchi, C.; Orlin, V. N.; Pietralla, N.; Sin, M.; Spitaleri, C.; Stopani, K. A.; Tesileanu, O.; Ur, C. A.; Ursu, I.; Utsunomiya, H.; Varlamov, V. V.; Weller, H. R.; Zamfir, N. V.; Zilges, A.

    2015-12-01

    The perspectives for photonuclear experiments at the new Extreme Light Infrastructure - Nuclear Physics (ELI-NP) facility are discussed in view of the need to accumulate novel and more precise nuclear data. The parameters of the ELI-NP gamma beam system are presented. The emerging experimental program, which will be realized at ELI-NP, is presented. Examples of day-one experiments with the nuclear resonance fluorescence technique, photonuclear reaction measurements, photofission experiments and studies of nuclear collective excitation modes and competition between various decay channels are discussed. The advantages which ELI-NP provides for all these experiments compared to the existing facilities are discussed.

  14. ELIMED, MEDical and multidisciplinary applications at ELI-Beamlines

    NASA Astrophysics Data System (ADS)

    Schillaci, F.; Anzalone, A.; Cirrone, G. A. P.; Carpinelli, M.; Cuttone, G.; Cutroneo, M.; De Martinis, C.; Giove, D.; Korn, G.; Maggiore, M.; Manti, L.; Margarone, D.; Musumarra, A.; Perozziello, F. M.; Petrovic, I.; Pisciotta, P.; Renis, M.; Ristic-Fira, A.; Romano, F.; Romano, F. P.; Schettino, G.; Scuderi, V.; Torrisi, L.; Tramontana, A.; Tudisco, S.

    2014-04-01

    ELI-Beamlines is one of the pillars of the pan-European project ELI (Extreme Light Infrastructure). It will be an ultra high-intensity, high repetition-rate, femtosecond laser facility whose main goal is generation and applications of high-brightness X-ray sources and accelerated charged particles in different fields. Particular care will be devoted to the potential applicability of laser-driven ion beams for medical treatments of tumors. Indeed, such kind of beams show very interesting peculiarities and, moreover, laser-driven based accelerators can really represent a competitive alternative to conventional machines since they are expected to be more compact in size and less expensive. The ELIMED project was launched thanks to a collaboration established between FZU-ASCR (ELI-Beamlines) and INFN-LNS researchers. Several European institutes have already shown a great interest in the project aiming to explore the possibility to use laser-driven ion (mostly proton) beams for several applications with a particular regard for medical ones. To reach the project goal several tasks need to be fulfilled, starting from the optimization of laser-target interaction to dosimetric studies at the irradiation point at the end of a proper designed transport beam-line. Researchers from LNS have already developed and successfully tested a high-dispersive power Thomson Parabola Spectrometer, which is the first prototype of a more performing device to be used within the ELIMED project. Also a Magnetic Selection System able to produce a small pencil beam out of a wide energy distribution of ions produced in laser-target interaction has been realized and some preliminary work for its testing and characterization is in progress. In this contribution the status of the project will be reported together with a short description of the of the features of device recently developed.

  15. Simulation of photofission experiments at the ELI-NP facility

    NASA Astrophysics Data System (ADS)

    Constantin, P.; Balabanski, D. L.; Cuong, P. V.

    2016-04-01

    An extensive experimental program for the study of photofission will take place at the Extreme Light Infrastructure - Nuclear Physics (ELI-NP) facility, where different actinide targets will be exposed to a brilliant gamma beam to produce fission fragments. We report on the implementation within the Geant4 simulation toolkit of the photofission process, of related background processes, and of extended ionic charge parameterization. These developments are used to evaluate the production rates of photofission fragments and their release efficiency from the actinide targets.

  16. 1. Historic American Buildings Survey Eli Lilly Company Photographic Department ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Eli Lilly Company Photographic Department - About 1937-1938 Gift courtesy of Edward D. James, FAIA, Preservation Officer SKETCH PLAN OF FARM Legend: (1) William Conner House; (2) Still house; (3) Milk house; (4) Museum; (5) Loom house; (6) Modern barns, grain and implement storage; (7) Three-eighths of a mile north or here on the river bank, William Conner lived in a double cabin trading post; (8) Trading post; (9) Conner cabin; (10) Pioneer barn - William Conner Prairie Farm, State Highway 234, Noblesville, Hamilton County, IN

  17. The ELI-NP facility for nuclear physics

    NASA Astrophysics Data System (ADS)

    Ur, C. A.; Balabanski, D.; Cata-Danil, G.; Gales, S.; Morjan, I.; Tesileanu, O.; Ursescu, D.; Ursu, I.; Zamfir, N. V.

    2015-07-01

    Extreme Light Infrastructure-Nuclear Physics (ELI-NP) is aiming to use extreme electromagnetic fields for nuclear physics research. The facility, currently under construction at Magurele-Bucharest, will comprise a high power laser system and a very brilliant gamma beam system. The technology involved in the construction of both systems is at the limits of the present-day's technological capabilities. The high power laser system will consist of two 10 PW lasers and it will produce intensities of up to 1023-1024 W/cm2. The gamma beam, produced via Compton backscattering of a laser beam on a relativistic electron beam, will be characterized by a narrow bandwidth (<0.5%) and tunable energy of up to almost 20 MeV. The research program of the facility covers a broad range of key topics in frontier fundamental physics and new nuclear physics. A particular attention is given to the development of innovative applications. In the present paper an overview of the project status and the overall performance characteristics of the main research equipment will be given. The main fundamental physics and applied research topics proposed to be studied at ELI-NP will also be briefly reviewed.

  18. Pharmacological and phytochemical studies of Cephäelis axillaris.

    PubMed

    Martín, M L; Gupta, M P; Ortiz de Urbina, A V; Karikas, G A; Gordaliza, M; Miguel del Corral, J M; San Román, L; Sánchez, C; San Feliciano, A

    1994-12-01

    The most significant effect, observed in the preliminary pharmacological evaluation of the whole ethanol extract and the alkaloidal fraction of Cephäelis axillaris, was the hyperemia of ears and external mucosas which was most probably due to an alpha-adrenergic blocking activity. In addition, both samples also induced a marked hypotension in normotensive as well as hypertensive (SHR) rats and inhibited the increases of blood pressure induced by i.v. administration of noradrenaline in pithed rats. The structures of the major alkaloidal components of the extract were elucidated on the basis of chemical characterization assays and IR, UV, 1H and 13C one and two-dimensional NMR analyses. PMID:7809213

  19. Chaos in the Showalter-Noyes-Bar-Eli model of the Belousov-Zhabotinskii reaction

    NASA Astrophysics Data System (ADS)

    Lindberg, David; Turner, Jack S.; Barkley, Dwight

    1990-03-01

    The observation of robust, large-scale chaos in the Showalter-Noyes-Bar-Eli model of the Belousov-Zhabotinskii reaction is reported. The chaos observed is comparable to that found in CSTR experiments at low flow rates.

  20. Straight talk with... Mahendra Rao by Dolgin Elie.

    PubMed

    Rao, Mahendra

    2011-10-01

    In October 2005, Mahendra Rao shocked the scientific community when he quit his job as head of the US National Institute on Aging's stem cell section and announced plans to go into industry. Rao felt that a ban at the time on federal funding for most human embryonic stem cell research hampered researchers in his division and prohibited him from doing the job he was hired to do. So he joined the research-tool giant Invitrogen (which later became Life Technologies) as vice president of regenerative medicine at the company's Maryland facility. Six years on, times have changed in the field of stem cell biology: rules governing taxpayer-backed research involving embryonic stem (ES) cells have been relaxed in the US, and induced pluripotent stem (iPS) cells have come into the fray. Prompted by those changes, Rao opted to return to the US National Institutes of Health (NIH) in August to head the new Intramural Center for Regenerative Medicine. The $52 million center was launched in early 2010 by the agency to develop new therapies using stem cell approaches. With a heightened focus at the NIH on translational medicine, Elie Dolgin spoke to Rao to find out how he plans to turn stem cell discoveries into cell-based therapies. PMID:21988971

  1. The Elicitin-Like Glycoprotein, ELI025, Is Secreted by the Pathogenic Oomycete Pythium insidiosum and Evades Host Antibody Responses

    PubMed Central

    Lerksuthirat, Tassanee; Lohnoo, Tassanee; Inkomlue, Ruchuros; Rujirawat, Thidarat; Yingyong, Wanta; Khositnithikul, Rommanee; Phaonakrop, Narumon; Roytrakul, Sittiruk; Sullivan, Thomas D.; Krajaejun, Theerapong

    2015-01-01

    Pythium insidiosum is a unique oomycete that can infect humans and animals. Patients with a P. insidiosum infection (pythiosis) have high rates of morbidity and mortality. The pathogen resists conventional antifungal drugs. Information on the biology and pathogenesis of P. insidiosum is limited. Many pathogens secrete proteins, known as effectors, which can affect the host response and promote the infection process. Elicitins are secretory proteins and are found only in the oomycetes, primarily in Phytophthora and Pythium species. In plant-pathogenic oomycetes, elicitins function as pathogen-associated molecular pattern molecules, sterol carriers, and plant defense stimulators. Recently, we reported a number of elicitin-encoding genes from the P. insidiosum transcriptome. The function of elicitins during human infections is unknown. One of the P. insidiosum elicitin-encoding genes, ELI025, is highly expressed and up-regulated at body temperature. This study aims to characterize the biochemical, immunological, and genetic properties of the elicitin protein, ELI025. A 12.4-kDa recombinant ELI025 protein (rELI025) was expressed in Escherichia coli. Rabbit anti-rELI025 antibodies reacted strongly with the native ELI025 in P. insidiosum’s culture medium. The detected ELI025 had two isoforms: glycosylated and non-glycosylated. ELI025 was not immunoreactive with sera from pythiosis patients. The region near the transcriptional start site of ELI025 contained conserved oomycete core promoter elements. In conclusion, ELI025 is a small, abundant, secreted glycoprotein that evades host antibody responses. ELI025 is a promising candidate for development of diagnostic and therapeutic targets for pythiosis. PMID:25793767

  2. The elicitin-like glycoprotein, ELI025, is secreted by the pathogenic oomycete Pythium insidiosum and evades host antibody responses.

    PubMed

    Lerksuthirat, Tassanee; Lohnoo, Tassanee; Inkomlue, Ruchuros; Rujirawat, Thidarat; Yingyong, Wanta; Khositnithikul, Rommanee; Phaonakrop, Narumon; Roytrakul, Sittiruk; Sullivan, Thomas D; Krajaejun, Theerapong

    2015-01-01

    Pythium insidiosum is a unique oomycete that can infect humans and animals. Patients with a P. insidiosum infection (pythiosis) have high rates of morbidity and mortality. The pathogen resists conventional antifungal drugs. Information on the biology and pathogenesis of P. insidiosum is limited. Many pathogens secrete proteins, known as effectors, which can affect the host response and promote the infection process. Elicitins are secretory proteins and are found only in the oomycetes, primarily in Phytophthora and Pythium species. In plant-pathogenic oomycetes, elicitins function as pathogen-associated molecular pattern molecules, sterol carriers, and plant defense stimulators. Recently, we reported a number of elicitin-encoding genes from the P. insidiosum transcriptome. The function of elicitins during human infections is unknown. One of the P. insidiosum elicitin-encoding genes, ELI025, is highly expressed and up-regulated at body temperature. This study aims to characterize the biochemical, immunological, and genetic properties of the elicitin protein, ELI025. A 12.4-kDa recombinant ELI025 protein (rELI025) was expressed in Escherichia coli. Rabbit anti-rELI025 antibodies reacted strongly with the native ELI025 in P. insidiosum's culture medium. The detected ELI025 had two isoforms: glycosylated and non-glycosylated. ELI025 was not immunoreactive with sera from pythiosis patients. The region near the transcriptional start site of ELI025 contained conserved oomycete core promoter elements. In conclusion, ELI025 is a small, abundant, secreted glycoprotein that evades host antibody responses. ELI025 is a promising candidate for development of diagnostic and therapeutic targets for pythiosis. PMID:25793767

  3. Implementation status of the extreme light infrastructure - nuclear physics (ELI-NP) project

    SciTech Connect

    Gales, S. Zamfir, N. V.

    2015-02-24

    The Project Extreme Light Infrastructure (ELI) is part of the European Strategic Forum for Research Infrastructures (ESFRI) Roadmap. ELI will be built as a network of three complementary pillars at the frontier of laser technologies. The ELI-NP pillar (NP for Nuclear Physics) is under construction near Bucharest (Romania) and will develop a scientific program using two 10 PW lasers and a Compton back-scattering high-brilliance and intense gamma beam, a marriage of laser and accelerator technology at the frontier of knowledge. In the present paper, the technical description of the facility, the present status of the project as well as the science, applications and future perspectives will be discussed.

  4. Implementation status of the extreme light infrastructure - nuclear physics (ELI-NP) project

    NASA Astrophysics Data System (ADS)

    Gales, S.; Zamfir, N. V.

    2015-02-01

    The Project Extreme Light Infrastructure (ELI) is part of the European Strategic Forum for Research Infrastructures (ESFRI) Roadmap. ELI will be built as a network of three complementary pillars at the frontier of laser technologies. The ELI-NP pillar (NP for Nuclear Physics) is under construction near Bucharest (Romania) and will develop a scientific program using two 10 PW lasers and a Compton back-scattering high-brilliance and intense gamma beam, a marriage of laser and accelerator technology at the frontier of knowledge. In the present paper, the technical description of the facility, the present status of the project as well as the science, applications and future perspectives will be discussed.

  5. Aquatic assessment of the Ely Copper Mine Superfund site, Vershire, Vermont

    USGS Publications Warehouse

    Seal, Robert R., II; Kiah, Richard G.; Piatak, Nadine M.; Besser, John M.; Coles, James F.; Hammarstrom, Jane M.; Argue, Denise M.; Levitan, Denise M.; Deacon, Jeffrey R.; Ingersoll, Christopher G.

    2010-01-01

    The information was used to develop an overall assessment of the impact on the aquatic system that appears to be a result of the acid rock drainage at the Ely Mine. More than 700 meters of Ely Brook, including two of the six ponds, were found to be severely impacted, on the basis of water-quality data and biological assessments. The reference location was of good quality based on the water quality and biological assessment. More than 3,125 meters of Schoolhouse Brook are also severely impacted, on the basis of water-quality data and biological assessments. The biological community begins to recover near the conflu

  6. Extreme Light Infrastructure Nuclear Physics (ELI-NP): Present status and perspectives

    NASA Astrophysics Data System (ADS)

    Zamfir, N. V.

    2016-05-01

    Extreme Light Infrastructure - Nuclear Physics (ELI-NP), a new Research Center under construction, will use extreme electromagnetic fields for nuclear physics research and will be operational in 2018. The status of the Project implementation will be presented. At ELI-NP, a high power laser system together with a very brilliant gamma beam are the two main research tools. Their targeted operational parameters will be described. The related experimental set-ups will be presented, together with the main directions of the research envisioned.

  7. 78 FR 21849 - Television Broadcasting Services; Ely, NV to Middletown Township, NJ

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-12

    ... From the Federal Register Online via the Government Publishing Office FEDERAL COMMUNICATIONS COMMISSION 47 CFR Part 73 Television Broadcasting Services; Ely, NV to Middletown Township, NJ AGENCY... U.S.C. 801(a)(1)(A). List of Subjects in 47 CFR Part 73 Television. Federal...

  8. [Validation of the Essen Quality of Life-Index for Eating Disorders (ELI)].

    PubMed

    Tagay, Sefik; Lindner, Marion; Friederich, Hans-Christoph; Schlottbohm, Ellen

    2015-09-01

    The aim of this study was the validation of a short disease-specific questionnaire (ELI, Essen Quality of Life Index for Eating Disorders) to measure the health-related quality of life in patients with eating disorders. A total of 182 currently ill and former eating disordered patients and 87 healthy controls completed the ELI questionnaire as well as other reliable and valid instruments (EDQOL, SF-12, EDI-2, FKB-20, SEED, BSI, IIP-D and SOC-13). In addition, 46 eating disorder patients completed the same questionnaires at the end of therapy. The ELI proved to have a high internal consistency of α=0.96. As expected, one main factor was found with a high declaration of variance of 71.25%. There is also evidence for very good construct validity and good sensitivity for change. Therefore, the ELI is an economic, reliable and valid instrument that assesses disease-specific health-related quality of life of individuals with eating disorders. The questionnaire can be recommended for research as well as clinical care contexts. PMID:25919059

  9. Clinical utility of the Duncan-Ely test for rectus femoris dysfunction during the swing phase of gait.

    PubMed

    Marks, M C; Alexander, J; Sutherland, D H; Chambers, H G

    2003-11-01

    The Ely Test (or Duncan-Ely test) has been accepted as a clinical tool to assess rectus femoris spasticity by passively flexing the knee rapidly while the patient lies prone in a relaxed state. In this retrospective review, patients' dynamic knee range of motion (ROM) during gait and an electromyogram (EMG) were compared with the results of the Ely test. Data for 70 patients (44 males, 26 females; 104 limbs) were included. Mean age of patients was 13 years, SD 9 years, range 4 years 5 months to 54 years. All patients were diagnosed with cerebral palsy (spastic diplegia, n = 42; spastic quadriplegia, n = 15, and hemiplegia, n = 13). All patients were ambulatory (50 independent, 20 with assistive devices). A standard matrix was used to calculate sensitivity and specificity of the Ely test as well as its positive and negative predictive value. For the gait variables examined (decreased dynamic knee ROM, timing of peak knee flexion, and abnormal EMG in swing) the sensitivity of the Ely test ranged from 56 to 59% and the specificity ranged from 64 to 85%. For the same variables the positive predictive value ranged from 91 to 98% and the negative predictive value ranged from 4 to 19%. The Ely test was shown to have a good positive predictive value (i.e. the certainty about the presence of rectus spasticity in patients with a positive Ely test result) for rectus femoris dysfunction during gait. PMID:14580132

  10. Notch effects on high-cycle fatigue properties of Ti 6Al 4V ELI alloy at cryogenic temperatures

    NASA Astrophysics Data System (ADS)

    Yuri, T.; Ono, Y.; Ogata, T.

    2006-01-01

    Notch effects on the high-cycle fatigue properties of the forged Ti-6Al-4V ELI alloy at cryogenic temperatures were investigated. Also, the high-cycle fatigue data were compared with the rolled Ti-5Al-2.5Sn ELI alloy. The one million cycles fatigue strength (FS) of the smooth specimen for the forged Ti-6Al-4V ELI alloy increased with a decrease of test temperature. However, the FS of each notched specimen at 4 K were lower than those at 77 K. On the other hand, the FS of the smooth and the notched specimens for the forged Ti-6Al-4V ELI alloy at 4 K were lower than those for the rolled Ti-5Al-2.5Sn ELI alloy. This is considered to be the early initiation of the fatigue crack in the forged Ti-6Al-4V ELI alloy compares with the forged Ti-5Al-2.5Sn ELI.

  11. Tensile properties of cast titanium alloys: Titanium-6Al-4V ELI and Titanium-5Al-2.5Sn ELI

    NASA Technical Reports Server (NTRS)

    Billinghurst, E. E., Jr.

    1992-01-01

    This work was performed to determine the tensile properties of cast, hot isostatic pressed (HIP'ed), and annealed titanium alloys, Ti-6Al-4V ELI and Ti-5Al-2.5Sn ELI, that are candidate materials for the space transportation main engine (STME) liquid hydrogen turbopump impeller. Samples of the cast alloys were HIP'ed, annealed, and machined into tensile specimens. The specimens were tested in air at ambient temperature (70 F) and also at -423 F in liquid hydrogen. The Ti-6Al-4V alloy had an average ultimate strength of 129.1 ksi at 70 F and 212.2 ksi at -423 F. The Ti-5Al-2.5Sn alloy had an average ultimate strength of 108.4 ksi at 70 degrees F and 185.0 ksi at -423 F. The ductility, as measured by reduction of area, for the Ti-6Al-4V averaged 15.2 percent at 70 F and 8.7 percent at -423 F, whereas for the Ti-5Al-2.5Sn alloy average reduction of area was 24.6 percent at 70 F and 11.7 percent at -423 F.

  12. Laser-based acceleration for nuclear physics experiments at ELI-NP

    NASA Astrophysics Data System (ADS)

    Tesileanu, O.; Asavei, Th.; Dancus, I.; Gales, S.; Negoita, F.; Turcu, I. C. E.; Ursescu, D.; Zamfir, N. V.

    2016-05-01

    As part of the Extreme Light pan-European research infrastructure, Extreme Light Infrastructure - Nuclear Physics (ELI-NP) in Romania will focus on topics in Nuclear Physics, fundamental Physics and applications, based on very intense photon beams. Laser-based acceleration of electrons, protons and heavy ions is a prerequisite for a multitude of laser-driven nuclear physics experiments already proposed by the international research community. A total of six outputs of the dual-amplification chain laser system, two of 100TW, two of 1PW and two of 10PW will be employed in 5 experimental areas, with the possibility to use long and short focal lengths, gas and solid targets, reaching the whole range of laser acceleration processes. We describe the main techniques and expectations regarding the acceleration of electrons, protons and heavy nuclei at ELI-NP, and some physics cases for which these techniques play an important role in the experiments.

  13. The design and production of Ti-6Al-4V ELI customized dental implants

    NASA Astrophysics Data System (ADS)

    Chahine, Gilbert; Koike, Mari; Okabe, Toru; Smith, Pauline; Kovacevic, Radovan

    2008-11-01

    This paper addresses the production of customized Ti-6Al-4V ELI dental implants via electron beam melting (EBM). The melting of Ti-6Al-4V ELI powder produces implants with great biocompatibility, fi ne mechanical performance, and a high bone ingrowth potential. The EBM technology is used to produce one-component dental implants that mimic the exact shape of the patient’s tooth, replacing the traditional, three-component, “screw-like” standardized dental implants currently used. The new generation of implants provides the possibility of simplifying pre-insertion procedures leading to faster healing time, and the potential of better and stronger osseointegration, specifi cally through incorporating lattice structure design.

  14. 6D phase space electron beam analysis and machine sensitivity studies for ELI-NP GBS

    NASA Astrophysics Data System (ADS)

    Giribono, A.; Bacci, A.; Curatolo, C.; Drebot, I.; Palumbo, L.; Petrillo, V.; Rossi, A. R.; Serafini, L.; Vaccarezza, C.; Vannozzi, A.; Variola, A.

    2016-09-01

    The ELI-NP Gamma Beam Source (GBS) is now under construction in Magurele-Bucharest (RO). Here an advanced source of gamma photons with unprecedented specifications of brilliance (>1021), monochromaticity (0.5%) and energy tunability (0.2-19.5 MeV) is being built, based on Inverse Compton Scattering in the head-on configuration between an electron beam of maximum energy 750 MeV and a high quality high power ps laser beam. These requirements make the ELI-NP GBS an advanced and challenging gamma ray source. The electron beam dynamics analysis and control regarding the machine sensitivity to the possible jitter and misalignments are presented. The effects on the beam quality are illustrated providing the basis for the alignment procedure and jitter tolerances.

  15. Perspectives for neutron and gamma spectroscopy in high power laser driven experiments at ELI-NP

    NASA Astrophysics Data System (ADS)

    Negoita, F.; Gugiu, M.; Petrascu, H.; Petrone, C.; Pietreanu, D.; Fuchs, J.; Chen, S.; Higginson, D.; Vassura, L.; Hannachi, F.; Tarisien, M.; Versteegen, M.; Antici, P.; Balabanski, D.; Balascuta, S.; Cernaianu, M.; Dancus, I.; Gales, S.; Neagu, L.; Petcu, C.; Risca, M.; Toma, M.; Turcu, E.; Ursescu, D.

    2015-02-01

    The measurement of energy spectra of neutrons and gamma rays emitted by nuclei, together with charge particles spectroscopy, are the main tools for understanding nuclear phenomena occurring also in high power laser driven experiments. However, the large number of particles emitted in a very short time, in particular the strong X-rays flash produced in laser-target interaction, impose adaptation of technique currently used in nuclear physics experiment at accelerator based facilities. These aspects are discussed (Section 1) in the context of proposed studies at high power laser system of ELI-NP. Preliminary results from two experiments performed at Titan (LLNL) and ELFIE (LULI) facilities using plastic scintillators for neutron detection (Section 2) and LaBr3(Ce) scintillators for gamma detection (Section 3) are presented demonstrating the capabilities and the limitations of the employed methods. Possible improvements of these spectroscopic methods and their proposed implementation at ELI-NP will be discussed as well in the last section.

  16. Evaluation of the stiffness and friction of Ti6Al4V ELI treated by glow discharge nitriding

    NASA Astrophysics Data System (ADS)

    Tavera, J. R.; Peña Ballesteros, D. Y.; Estupiñán Duran, H. A.

    2016-02-01

    In this study, an evaluation of the elastic-plastic surface hardening on Ti6Al4V ELI titanium nitride films obtained by glow discharge method was carried out by nanoindentation tests according to the standard ISO 14577. The nanotribological properties (metal-metal) were also evaluated using the pin-on-disc system Ti6Al4V surface deposition ELI with nitrogen, obtaining a correlation between the coefficient of friction of Ti6Al4V ELI treated by PVD and the Young's modulus of the respective substrate modified by PVD. To characterize the substrate for the characterization tests, scanning electron microscopy, atomic force microscopy and X-ray diffraction and contact angle were carried out. The results demonstrated that the substrates nitrided improved mechanical and tribological properties, hardness, Young's modulus and coefficient of friction, making the alloy Ti6Al4V ELI support axial loads in tension and compression.

  17. Study of nuclear reactions in laser plasmas at future ELI-NP facility

    NASA Astrophysics Data System (ADS)

    Lanzalone, G.; Altana, C.; Anzalone, A.; Cappuzzello, F.; Cavallaro, M.; Gizzi, L. A.; Labate, L.; Lamia, L.; Mascali, D.; Muoio, A.; Negoita, F.; Odorici, F.; Petrascu, H.; Trifirò, A.; Trimarchi, M.; Tudisco, S.

    2016-05-01

    In this contribution we will present the future activities that our collaboration will carry out at ELI-NP (Extreme Light Infrastructure Nuclear Physics), the new multi peta-watt Laser facility, currently under construction at Bucharest (Romania). The activities concerns the study of nuclear reactions in laser plasmas. In this framework we proposed the construction of a new, general-purpose experimental set-up able to detect and identify neutrons and charged particles.

  18. Geographic variation in the elicitin-like glycoprotein, ELI025, of Pythium insidiosum isolated from human and animal subjects.

    PubMed

    Lerksuthirat, Tassanee; Lohnoo, Tassanee; Rujirawat, Thidarat; Yingyong, Wanta; Jongruja, Nujarin; Krajaejun, Theerapong

    2015-10-01

    Oomycetes are fungus-like in appearance, but form a distinct clade within the eukaryotes. While most pathogenic oomycetes infect plants, the understudied oomycete Pythium insidiosum infects humans and animals, and causes a life-threatening infectious disease, called pythiosis. Phylogenetic analyses divide P. insidiosum into 3 groups, according to geographic origins: Clade-I (Americas), Clade-II (Asia and Australia), and Clade-III (Thailand). Surgical removal of the infected organ is the inevitable treatment for patients with pythiosis, but it is often too late or unsuccessful, and many patients die from advanced infection. Understanding P. insidiosum's basic biology could lead to improved infection control. Elicitins, a unique group of proteins found only in oomycetes, are involved in sterol acquisition and stimulation of host responses. Recently, we identified glycosylated and non-glycosylated forms of the elicitin-like protein, ELI025, which is secreted by P. insidiosum, and detected during P. insidiosum infection. In this study, we investigated geographic variation of ELI025 in 24 P. insidiosum strains isolated from humans, animals, and the environment. Genotypes of ELI025, based on 2 sets of PCR primers, correlated well with rDNA-based phylogenetic grouping. Unlike strains in Clade-I and -II, Clade-III strains secreted no glycosylated ELI025. Sera from 17 pythiosis patients yielded a broad range of antibody responses against ELI025, and ∼30% lacked reactivity against the protein. Selective production or secretion of glycosylated ELI025 by different P. insidiosum strains might contribute to the variable host antibody responses. In conclusion, ELI025 was secreted by all P. insidiosum strains isolated from different hosts and geographic origins, but the protein had different biochemical, and immunological characteristics. These finding contribute to the better understanding of the biology and evolution of P. insidiosum, and could lead to appropriate clinical

  19. Eruptive history of an alkali basaltic diatreme from Elie Ness, Fife, Scotland

    NASA Astrophysics Data System (ADS)

    Gernon, T. M.; Upton, B. G. J.; Hincks, T. K.

    2013-05-01

    The Elie Ness diatreme (Fife, Scotland) is an ideal place to study the internal architecture and emplacement processes of diatremes. Elie Ness is one of approximately 100 alkali basaltic diatremes and intrusions in the East Fife area, emplaced during Upper Carboniferous to Early Permian times into an extensive rift system in the northern Variscan foreland. Within the diatreme, seven lithofacies and three lithofacies associations (LFAs 1-3) are recognised. Field, petrographic and geochemical studies demonstrate that the diatreme experienced a protracted history of eruption and infill, initially driven by volatile expansion and later by magma-water interaction. Massive lapilli tuffs of LFA 1 contain abundant highly vesicular juvenile scoria and magma-coated clasts, which are best explained by a magmatic origin for the early explosive eruptions. On a large-scale, the tuffs are well mixed and locally exhibit small-scale degassing structures attributed to fluidisation processes occurring within the diatreme fill. The occurrence of abundant volcaniclastic autoliths and megablocks within LFA 1 can be explained by subsidence of volcaniclastic strata from the maar crater and upper diatreme during emplacement. Pyroclastic density current deposits of LFA 2 form a series of continuous sheets across the diatreme, some of which may have originated from phreatomagmatic explosions in a neighbouring vent. We attribute the overall bedding pattern to a combination of primary volcanic processes and post-depositional folding related to movement along an adjacent fault. Minor steeply inclined breccias and tuffs of LFA 3 cross-cut the LFA 2 succession and are interpreted as late-stage volcaniclastic dykes and conduits, signalling the final phase of eruptive activity at Elie Ness. The study offers new insights into the volcanic evolution of diatremes fed by low viscosity, alkali-rich magmas.

  20. Depositional processes of the basaltic Elie Ness diatreme, East Fife, Scotland

    NASA Astrophysics Data System (ADS)

    Gernon, Thomas; Hincks, Thea

    2010-05-01

    The East Fife coast of Scotland exposes multiple (~100) volcanic vents or diatremes of late Carboniferous to early Permian age. Here, we present preliminary results of detailed geological mapping of the Elie Ness (EN) diatreme. The key objective was to map the volcanic structure and lithofacies of the vent-fill, and to determine the eruption styles and key emplacement processes that occur more generally in basaltic maar-diatreme systems. Within the EN diatreme, seven lithofacies and three lithofacies associations (LFA 1-3) were recognised. Preliminary results demonstrate that the diatreme had a protracted history of eruption and infill. The massive lapilli tuffs of LFA 1 are texturally and compositionally homogeneous with occasional degassing structures, making them similar to typical massive volcaniclastic deposits infilling kimberlite pipes. The formation of such deposits are attributed to gas-fluidisation processes operating within the vent. The occurrence within LFA 1 of abundant volcaniclastic autoliths and megablocks together with steeply inclined lenticular breccia and tuff packages, makes the deposits similar to marginal lithofacies of the Jwaneng Centre kimberlite pipe, Botswana. All these features can be explained by subsidence of volcaniclastic strata from the surrounding tephra ring during emplacement. The steep internal contacts between the lithofacies of LFA 1 can be explained by variations in gas flux as the main eruptive phase waned. Pyroclastic base surge deposits of LFA 2 form a series of continuous sheets across the EN diatreme, and are therefore likely to have originated from a neighbouring pipe. The most probable source of the LFA 2 pyroclastic surges is a small vent to the NE of Elie Ness, where similar diffuse stratified lithofacies are observed. Minor steeply-inclined breccias and tuffs of LFA 3 cross-cut bedded tuffs of LFA 2, and are therefore likely to represent late-stage dykes and conduits. A significant observation is that the diatreme

  1. Cryogenic stopping cell for photofission fragments at the ELI-NP facility

    SciTech Connect

    Constantin, P. Balabanski, D. L.; Cuong, P. V.

    2015-10-15

    The brilliant gamma beam at the future Extreme Light Infrastructure - Nuclear Physics (ELI-NP) facility will be used to generate a beam of exotic neutron-rich isotopes via photofission of actinide targets. We present simulations with the Geant4 toolkit of the photofission process for the design and optimization of the expected performance parameters of the Cryogenic Stopping Cell (CSC). The CSC will be used to extract the photofission fragments into the secondary beam of about 10{sup 6} ions/s. We propose an experimental program to study refractory neutron-rich isotopes.

  2. 100-J level amplifier concepts for HiLASE and ELI-Beamlines

    NASA Astrophysics Data System (ADS)

    Sikocinski, P.; Divoky, M.; Lucianetti, A.; Sawicka, M.; Novak, J.; Rus, B.; Mocek, T.

    2012-07-01

    We present comparison of two alternative layouts of a 100 J cryogenically cooled Yb:YAG multi-slab laser system operating at 10 Hz for HiLASE and ELI Beamlines projects. In the first approach, the 100 J slab amplifier consists of a preamplifier and power amplifier, while in the second approach it uses single power amplifier with two amplifier heads. These two concepts are compared, with respect to output power, B-integral, accumulated B-integral, and peak fluence. Results are obtained by simulating beam propagation in MIRÓ code and calculating stored energy in the amplifier by homemade ray-tracing MATLAB code for amplified spontaneous emission evaluation.

  3. Identification of Conserved MEL-28/ELYS Domains with Essential Roles in Nuclear Assembly and Chromosome Segregation.

    PubMed

    Gómez-Saldivar, Georgina; Fernandez, Anita; Hirano, Yasuhiro; Mauro, Michael; Lai, Allison; Ayuso, Cristina; Haraguchi, Tokuko; Hiraoka, Yasushi; Piano, Fabio; Askjaer, Peter

    2016-06-01

    Nucleoporins are the constituents of nuclear pore complexes (NPCs) and are essential regulators of nucleocytoplasmic transport, gene expression and genome stability. The nucleoporin MEL-28/ELYS plays a critical role in post-mitotic NPC reassembly through recruitment of the NUP107-160 subcomplex, and is required for correct segregation of mitotic chromosomes. Here we present a systematic functional and structural analysis of MEL-28 in C. elegans early development and human ELYS in cultured cells. We have identified functional domains responsible for nuclear envelope and kinetochore localization, chromatin binding, mitotic spindle matrix association and chromosome segregation. Surprisingly, we found that perturbations to MEL-28's conserved AT-hook domain do not affect MEL-28 localization although they disrupt MEL-28 function and delay cell cycle progression in a DNA damage checkpoint-dependent manner. Our analyses also uncover a novel meiotic role of MEL-28. Together, these results show that MEL-28 has conserved structural domains that are essential for its fundamental roles in NPC assembly and chromosome segregation. PMID:27341616

  4. Perspectives for neutron and gamma spectroscopy in high power laser driven experiments at ELI-NP

    SciTech Connect

    Negoita, F. Gugiu, M. Petrascu, H. Petrone, C. Pietreanu, D.; Fuchs, J.; Chen, S.; Higginson, D.; Vassura, L.; Hannachi, F.; Tarisien, M.; Versteegen, M.; Antici, P.; Balabanski, D.; Balascuta, S.; Cernaianu, M.; Dancus, I.; Gales, S.; Neagu, L.; Petcu, C.; and others

    2015-02-24

    The measurement of energy spectra of neutrons and gamma rays emitted by nuclei, together with charge particles spectroscopy, are the main tools for understanding nuclear phenomena occurring also in high power laser driven experiments. However, the large number of particles emitted in a very short time, in particular the strong X-rays flash produced in laser-target interaction, impose adaptation of technique currently used in nuclear physics experiment at accelerator based facilities. These aspects are discussed (Section 1) in the context of proposed studies at high power laser system of ELI-NP. Preliminary results from two experiments performed at Titan (LLNL) and ELFIE (LULI) facilities using plastic scintillators for neutron detection (Section 2) and LaBr{sub 3}(Ce) scintillators for gamma detection (Section 3) are presented demonstrating the capabilities and the limitations of the employed methods. Possible improvements of these spectroscopic methods and their proposed implementation at ELI-NP will be discussed as well in the last section.

  5. Identification of Conserved MEL-28/ELYS Domains with Essential Roles in Nuclear Assembly and Chromosome Segregation

    PubMed Central

    Hirano, Yasuhiro; Mauro, Michael; Lai, Allison; Ayuso, Cristina; Haraguchi, Tokuko; Hiraoka, Yasushi; Piano, Fabio

    2016-01-01

    Nucleoporins are the constituents of nuclear pore complexes (NPCs) and are essential regulators of nucleocytoplasmic transport, gene expression and genome stability. The nucleoporin MEL-28/ELYS plays a critical role in post-mitotic NPC reassembly through recruitment of the NUP107-160 subcomplex, and is required for correct segregation of mitotic chromosomes. Here we present a systematic functional and structural analysis of MEL-28 in C. elegans early development and human ELYS in cultured cells. We have identified functional domains responsible for nuclear envelope and kinetochore localization, chromatin binding, mitotic spindle matrix association and chromosome segregation. Surprisingly, we found that perturbations to MEL-28’s conserved AT-hook domain do not affect MEL-28 localization although they disrupt MEL-28 function and delay cell cycle progression in a DNA damage checkpoint-dependent manner. Our analyses also uncover a novel meiotic role of MEL-28. Together, these results show that MEL-28 has conserved structural domains that are essential for its fundamental roles in NPC assembly and chromosome segregation. PMID:27341616

  6. Strong field physics and QED experiments with ELI-NP 2×10PW laser beams

    SciTech Connect

    Turcu, I. C. E. Balascuta, S. Negoita, F.; Jaroszynski, D.; McKenna, P.

    2015-02-24

    The ELI-NP facility will focus a 10 PW pulsed laser beam at intensities of ∼10{sup 23} W/cm{sup 2} for the first time, enabling investigation of the new physical phenomena at the interfaces of plasma, nuclear and particle physics. The electric field in the laser focus has a maximum value of ∼10{sup 15} V/m at such laser intensities. In the ELI-NP Experimental Area E6, we propose the study of Radiation Reaction, Strong Field Quantum Electrodynamics (QED) effects and resulting production of Ultra-bright Sources of Gamma-rays which could be used for nuclear activation. Two powerful, synchronized 10 PW laser beams will be focused in the E6 Interaction Chamber on either gas or solid targets. One 10 PW beam is the Pump-beam and the other is the Probe-beam. The focused Pump beam accelerates the electrons to relativistic energies. The accelerated electron bunches interact with the very high electro-magnetic field of the focused Probe beam. The layout of the experimental area E6 will be presented with several options for the experimental configurations.

  7. Strain-based fatigue data for Ti-6Al-4V ELI under fully-reversed and mean strain loads.

    PubMed

    Carrion, Patricio E; Shamsaei, Nima

    2016-06-01

    This article presents the experimental data supporting the study to obtain the mean strain/stress effects on the fatigue behavior of Ti-6Al-4V ELI. A series of strain-controlled fatigue experiments on Ti-6Al-4V ELI were performed at four strain ratios (-1, -0.5, 0, and 0.5). Two types of data are included for each specimen. These are the hysteresis stress-strain responses for the cycle in a log10 increment, and the maximum and minimum stress-strain responses for each cycle. Fatigue lives are also reported for all the experiments. PMID:26952022

  8. Helium concentrations in soil gas of the Ely and Delta 1 degree x 2 degrees quadrangles. Basin and Range Province

    USGS Publications Warehouse

    Reimer, G.M.; Bowles, C.G.

    1983-01-01

    A reconnaissance soil-gas helium survey was made of the Ely, Nevada and Delta, Utah 1? x 2? quadrangles in the Basin and Range Province. Helium concentrations in 510 samples ranged from -147 to 441 ppb He with respect to ambient air. The median helium value for the study area was 36 ppb. Concentrations of more than 100 ppb He, and less than -20 ppb He, occur more commonly in the Ely Quadrangle and are especially numerous in the western one-half of this quadrangle. The data are presented both in figures and tables, and some of the geologic factors that may affect the helium distribution are discussed.

  9. The Implications of John Hart Ely's Conceptual Framework for Interpretation of First Amendment Questions: The Continuation of Balancing in the Free Expression Arena.

    ERIC Educational Resources Information Center

    Trapp, Mary E.

    Examining interpretive approaches to the First Amendment free speech and press clause, this paper focuses on the conceptual framework proposed by John Hart Ely. Other First Amendment tests examined include clear and present danger, balancing, the absolute test, and A. Meiklejohn's "absolute" test. Following an analysis of Ely's First Amendment…

  10. ELI/SBP'S UVB (VACUUM VAPORIZATION WELL) SYSTEM FOR TREATMENT OF VOC-CONTAMINATED SOILS; INNOVATIVE TECHNOLOGY EVALUATION REPORT

    EPA Science Inventory

    This report summarizes the findings of an evaluation of the Unterdruck-Verdampfer-Brunnen (UVB) technology developed by IEG Technologies (IEG) and licensed in the eastern United States by Environmental Laboratories, Inc. (ELI) and SBP Technologies (SBP). This evaluation was cond...

  11. National uranium resource evaluation program: hydrogeochemical and stream sediment reconnaissance basic data for Ely quadrangle, Nevada; Utah

    SciTech Connect

    Not Available

    1981-10-15

    Field and laboratory data are presented for 1937 sediment samples from the Ely Quadrangle, Nevada; Utah. The samples were collected by Savannah River Laboratory; laboratory analysis and data reporting were performed by the Uranium Resource Evaluation Project at Oak Ridge, Tennessee.

  12. Eli Whitney's Patent for the Cotton Gin. The Constitution Community: Revolution and the New Nation (1754-1820s).

    ERIC Educational Resources Information Center

    Schur, Joan Brodsky

    This lesson focuses on the power of the U.S. Congress to pass laws related to issuing patents. Using Eli Whitney's 1812 Congressional petition to extend the patent on his cotton gin as an example, the lesson correlates to the National History Standards and the National Standards for Civics and Government. It contains two primary source documents,…

  13. CFL Labeling Harmonization in the United States, China, Brazil andELI Member Countries: Specifications, Testing, and MutualRecognition

    SciTech Connect

    Fridley, David; Lin, Jiang; Denver, Andrea; Biermayer, Peter; Dillavou, Tyler

    2005-07-20

    This report examines critical differences among energy-efficient labeling programs for CFLs in Brazil, China, the United States, and the seven members of the international Efficient Lighting Initiative (ELI) in terms of technical specifications and test procedures, and review issues related to international harmonization of these standards.

  14. A conceptual design of an electron spectrometer for ELI-NP

    SciTech Connect

    Balascuta, S. Turcu, I. C. E.

    2015-02-24

    We present the geometry and field parameters of an Electron Spectrometer (ES) with two dipole magnets, considered for electron energy measurements at the High Fields QED experimental area at ELI-NP. The first magnet is a 2 meter long permanent magnet, placed inside the Interaction Chamber (IC). The second magnet is a 1.5 meters long electromagnet, placed outside IC. The pulsed electron beam will be produced by the 10 PW pulsed Laser, ‘pump-beam’, focused into one meter long capillary low density plasma cell. A second 10 PW pulsed Laser, ‘probe-beam’, will interact with the relativistic electron bunch providing the strong electromagnetic field. The ES will measure the subtle changes in the electron energy spectrum as a result of the electron beam interaction with the probe-beam field.

  15. Positron production at extreme light infrastructure – nuclear physics (ELI-NP)

    SciTech Connect

    Oprisa, A. Balascuta, S. Ur, C. A.

    2015-02-24

    Applied and material physics studies with positron beams of Fermi–surfaces, defects, interfaces etc. offer excellent diagnostics tools. At ELI-NP, an intense γ beam of about 10{sup 11} photons/s with energies up to 3.5 MeV will be used to generate a positron beam via pair production in a tungsten converter target. To obtain a high intensity beam of moderated positrons the design of the positron source is of high importance. The design of a dedicated positron source at ELI–NP is being investigated based on extensive GEANT4 simulations. The goal of the simulations is to optimize the geometry of the target and the gamma beam collimation. We present here the characteristics of the positron beam obtained for different geometries of the converter target.

  16. A Journey with Elie Metchnikoff: From Innate Cell Mechanisms in Infectious Diseases to Quantum Biology

    PubMed Central

    Merien, Fabrice

    2016-01-01

    Many reviews of Elie Metchnikoff’s work have been published, all unanimously acknowledging the significant contributions of his cellular theory to the fields of immunology and infectious diseases. In 1883, he published a key paper describing phagocytic cells in frogs. His descriptions were not just about phagocytes involved in host defense, he also described how these specialized cells eliminated degenerating or dying cells of the host. This perspective focuses on key concepts developed by Metchnikoff by presenting relevant excerpts of his 1883 paper and matching these concepts with challenges of modern immunology. A new approach to macrophage polarization is included to introduce some creative thinking about the exciting emerging area of quantum biology. PMID:27379227

  17. The development of molecularly targeted anticancer therapies: an Eli Lilly and Company perspective.

    PubMed

    Perry, William L; Weitzman, Aaron

    2005-03-01

    The ability to identify activated pathways that drive the growth and progression of cancer and to develop specific and potent inhibitors of key proteins in these pathways promises to dramatically change the treatment of cancer: A patient's cancer could be characterized at the molecular level and the information used to select the best treatment options. The development of successful therapies not only requires extensive target validation, but also new approaches to evaluating drug efficacy in animal models and in the clinic compared to the development of traditional cytotoxic agents. This article highlights Eli Lilly and Company's approach to developing targeted therapies, from target identification and validation through evaluation in the clinic. A selection of drugs in the Lilly Oncology pipeline is also discussed. PMID:16166991

  18. ELI-Beamlines: development of next generation short-pulse laser systems

    NASA Astrophysics Data System (ADS)

    Rus, B.; Bakule, P.; Kramer, D.; Naylon, J.; Thoma, J.; Green, J. T.; Antipenkov, R.; Fibrich, M.; Novák, J.; Batysta, F.; Mazanec, T.; Drouin, M. A.; Kasl, K.; Baše, R.; Peceli, D.; Koubíková, L.; Trojek, P.; Boge, R.; Lagron, J. C.; Vyhlídka, Å.; Weiss, J.; Cupal, J.,; Hřebíček, J.; Hříbek, P.; Durák, M.; Polan, J.; Košelja, M.; Korn, G.; Horáček, M.; Horáček, J.; Himmel, B.; Havlíček, T.; Honsa, A.; Korouš, P.; Laub, M.; Haefner, C.; Bayramian, A.; Spinka, T.; Marshall, C.; Johnson, G.; Telford, S.; Horner, J.; Deri, B.; Metzger, T.; Schultze, M.; Mason, P.; Ertel, K.; Lintern, A.; Greenhalgh, J.; Edwards, C.; Hernandez-Gomez, C.; Collier, J.; Ditmire, T.,; Gaul, E.; Martinez, M.; Frederickson, C.; Hammond, D.; Malato, C.; White, W.; Houžvička, J.

    2015-05-01

    Overview of the laser systems being built for ELI-Beamlines is presented. The facility will make available high-brightness multi-TW ultrashort laser pulses at kHz repetition rate, PW 10 Hz repetition rate pulses, and kilojoule nanosecond pulses for generation of 10 PW peak power. The lasers will extensively employ the emerging technology of diode-pumped solid-state lasers (DPSSL) to pump OPCPA and Ti:sapphire broadband amplifiers. These systems will provide the user community with cutting-edge laser resources for programmatic research in generation and applications of high-intensity X-ray sources, in particle acceleration, and in dense-plasma and high-field physics.

  19. Radiation field characterization and shielding studies for the ELI Beamlines facility

    NASA Astrophysics Data System (ADS)

    Ferrari, A.; Amato, E.; Margarone, D.; Cowan, T.; Korn, G.

    2013-05-01

    The ELI (Extreme Light Infrastructure) Beamlines facility in the Czech Republic, which is planned to complete the installation in 2015, is one of the four pillars of the ELI European project. Several laser beamlines with ultrahigh intensities and ultrashort pulses are foreseen, offering versatile radiation sources in an unprecedented energy range: laser-driven particle beams are expected to range between 1 and 50 GeV for electrons and from 100 MeV up to 3 GeV for protons. The number of particles delivered per laser shot is estimated to be 109-1010 for the electron beams and 1010-1012 for the proton beams. The high energy and current values of the produced particles, together with the potentiality to operate at 10 Hz laser repetition rate, require an accurate study of the primary and secondary radiation fields to optimize appropriate shielding solutions: this is a key issue to minimize prompt and residual doses in order to protect the personnel, reduce the radiation damage of electronic devices and avoid strong limitations in the operational time. A general shielding study for the 10 PW (0.016 Hz) and 2 PW (10 Hz) laser beamlines is presented here. Starting from analytical calculations, as well as from dedicated simulations, the main electron and proton fields produced in the laser-matter interaction have been described and used to characterize the "source terms" in full simulations with the Monte Carlo code FLUKA. The secondary radiation fields have been then analyzed to assess a proper shielding. The results of this study and the proposed solutions for the beam dumps of the high energy beamlines, together with a cross-check analysis performed with the Monte Carlo code GEANT4, are presented.

  20. The ecotoxicological recovery of Ely Creek and tributaries (Lee County, VA) after remediation of acid mine drainage.

    PubMed

    Simon, Mathew L; Cherry, Donald S; Currie, Rebecca J; Zipper, Carl E

    2012-04-01

    The Ely Creek watershed (Lee County, VA) was determined in 1995 to be the most negatively affected by acid mine drainage (AMD) within the Virginia coalfield. This determination led the US Army Corps of Engineers to design and build passive wetland remediation systems at two major AMD seeps affecting Ely Creek. This study was undertaken to determine if ecological recovery had occurred in Ely Creek. The results indicate that remediation had a positive effect on all monitoring sites downstream of the remediated AMD seeps. At the site most impacted by AMD, mean pH was 2.93 prior to remediation and improved to 7.14 in 2004. Benthic macroinvertebrate surveys revealed that one AMD influenced site had increased taxa richness from zero taxa in 1997 to 24 in 2004. While in situ testing of Asian clams resulted in zero survival at five of seven AMD influenced sites prior to remediation, some clams survived at all sites after. Clam survival was found to be significantly less than upstream references at only two sites, both downstream of un-mitigated AMD seeps in 2004. An ecotoxicological rating (ETR) system that combined ten biotic and abiotic parameters was developed as an indicator of the ecological status for each study site. A comparison of ETRs from before and after remediation demonstrated that all sites downstream of the remediation had experienced some level of recovery. Although the remediation has improved the ecological health of Ely Creek, un-mitigated AMD discharges are still negatively impacting the watershed. PMID:22371009

  1. The ecotoxicological recovery of Ely Creek and tributaries (Lee County, VA) after remediation of acid mine drainage.

    PubMed

    Simon, Matthew L; Cherry, Donald S; Currie, Rebecca J; Zipper, Carl E

    2006-12-01

    The Ely Creek watershed (Lee County, VA) was determined in 1995 to be the most negatively affected by acid mine drainage (AMD) within the Virginia coalfield. This determination led the US Army Corps of Engineers to design and build passive wetland remediation systems at two major AMD seeps affecting Ely Creek. This study was undertaken to determine if ecological recovery had occurred in Ely Creek. The results indicate that remediation had a positive effect on all monitoring sites downstream of the remediated AMD seeps. At the site most impacted by AMD, mean pH was 2.93 prior to remediation and improved to 7.14 in 2004. Benthic macroinvertebrate surveys revealed that one AMD influenced site had increased taxa richness from zero taxa in 1997 to 24 in 2004. While in situ testing of Asian clams resulted in zero survival at five of seven AMD influenced sites prior to remediation, some clams survived at all sites after. Clam survival was found to be significantly less than upstream references at only two sites, both downstream of un-mitigated AMD seeps in 2004. An ecotoxicological rating (ETR) system that combined ten biotic and abiotic parameters was developed as an indicator of the ecological status for each study site. A comparison of ETRs from before and after remediation demonstrated that all sites downstream of the remediation had experienced some level of recovery. Although the remediation has improved the ecological health of Ely Creek, un-mitigated AMD discharges are still negatively impacting the watershed. PMID:16770499

  2. Nuclear Physics with 10 PW laser beams at Extreme Light Infrastructure - Nuclear Physics (ELI-NP)

    NASA Astrophysics Data System (ADS)

    Zamfir, N. V.

    2014-05-01

    The field of the uncharted territory of high-intensity laser interaction with matter is confronted with new exotic phenomena and, consequently, opens new research perspectives. The intense laser beams interacting with a gas or solid target generate beams of electrons, protons and ions. These beams can induce nuclear reactions. Electrons also generate ions high-energy photons via bremsstrahlung processes which can also induce nuclear reactions. In this context a new research domain began to form in the last decade or so, namely nuclear physics with high power lasers. The observation of high brilliance proton beams of tens of MeV energy from solid targets has stimulated an intense research activity. The laser-driven particle beams have to compete with conventional nuclear accelerator-generated beams. The ultimate goal is aiming at applications of the laser produced beams in research, technology and medicine. The mechanism responsible for ion acceleration are currently subject of intensive research in many laboratories in the world. The existing results, experimental and theoretical, and their perspectives are reviewed in this article in the context of IZEST and the scientific program of ELI-NP.

  3. ELiXIR—Solid-State Luminaire With Enhanced Light Extraction by Internal Reflection

    NASA Astrophysics Data System (ADS)

    Allen, Steven C.; Steckl, Andrew J.

    2007-06-01

    A phosphor-converted light-emitting diode (pcLED) luminaire featuring enhanced light extraction by internal reflection (ELiXIR) with efficacy of 60 lm/W producing 18 lumens of yellowish green light at 100 mA is presented. The luminaire consists of a commercial blue high power LED, a polymer hemispherical shell lens with interior phosphor coating, and planar aluminized reflector. High extraction efficiency of the phosphor-converted light is achieved by separating the phosphor from the LED and using internal reflection to steer the light away from lossy reflectors and the LED package and out of the device. At 10 and 500 mA, the luminaire produces 2.1 and 66 lumens with efficacies of 80 and 37 lm/W, respectively. Technological improvements over existing commercial LEDs, such as more efficient pcLED packages or, alternatively, higher efficiency green or yellow for color mixing, will be essential to achieving 150 200 lm/W solid-state lighting. Advances in both areas are demonstrated.

  4. Ultrafast beam dump materials and mirror coatings tested with the ELI beamlines LIDT test station

    NASA Astrophysics Data System (ADS)

    Durák, Michal; Kramer, Daniel; Velpula, Praveen K.; Cupal, Josef; Medřík, TomáÅ.¡; Hřebíček, Jan; Golasowski, Jiří; Peceli, Davorin; Fekete, Ladislav; Å tepán, Václav; Kozlová, Michaela; Rus, Bedřich

    2015-11-01

    The ELI Beamlines project will deliver ultrafast laser pulses with peak powers up to 10PW available every minute and PW class beams at 10Hz complemented by a 10TW 1kHz beamline. To properly determine damage thresholds of involved optical components in conditions similar to the operational environment and with expected laser parameters, a high vacuum LIDT test station was constructed at PALS facility. Our study presents results of ISO based S-on-1 and R-on-1 tests in femtosecond regime (50fs, 800nm, 10Hz/1kHz) performed on two different types of coatings: a) highabsorption black coatings with low outgassing rates, intended for use as a beam dump surface; and b) high-reflectivity, low-dispersion 45° AOI ultrafast mirror coatings. Testing of absorptive coatings was accompanied with QMS residual gas analysis to verify, that high intensity laser radiation approaching the damage threshold does not increase concentration of volatile organic compounds in the vacuum chamber. In case of HR mirror coatings, we also investigate the effect of cleaning on LIDT value, comparing characteristic S-on-1 curves of given sample with values obtained after 12h immersion in ethanol-water solution.

  5. Benthic macroinvertebrate assemblages and sediment toxicity testing in the Ely Creek watershed restoration project

    SciTech Connect

    Soucek, D.J.; Currie, R.J.; Cherry, D.S.; Latimer, H.A.; Trent, G.C.

    1998-12-31

    The Ely Creek watershed in Lee County, Virginia, contains an abundance of abandoned mined land (AML) seeps that contaminate the majority of the creek and its confluence into Big Stone Creek. Contaminated sediments had high concentrations of iron ({approximately}10,000 mg/kg), aluminum ({approximately}1,500 mg/kg), magnesium ({approximately}400 mg/kg) and manganese ({approximately}150 mg/kg). Copper and zinc generally ranged from 3 to 20 mg/kg. Benthic macroinvertebrates surveys at six of 20 sites sampled in the watershed yielded no macroinvertebrates, while eight others had total abundances of 1 to 9 organisms. Four reference sites contained {ge}100 organisms and at least 14 different taxa. Laboratory, 10-day survival/impairment sediments tests with Daphnia magna did not support the field data. Mortality of 92 to 100% for D. magna occurred in samples collected from six cities. Daphnid reproduction was more sensitive than laboratory test organism survivorship; however, neither daphnid survivorship nor reproduction were good predictors of taxa richness. Laboratory test concerns included the use of a reference diluent water rather than site specific diluent water.

  6. Straight talk with...Stephen O'Brien. Interviewed by Elie Dolgin.

    PubMed

    O'Brien, Stephen

    2013-01-01

    Stephen O'Brien joined the US National Cancer Institute as a post doc in 1971 and climbed the ranks to become head of the institute's Laboratory of Genomic Diversity, a position he held for 25 years. But, after four decades at the government agency, O'Brien was ready for something new. In December 2011, he stepped down and took up a three-year, $5 million 'megagrant' in Russia through a program started a year earlier by the Russian Ministry of Education and Science to attract big-name researchers to work at least part-time in that country. O'Brien used his money to help launch the Theodosius Dobzhansky Center for Genome Bioinformatics at Saint Petersburg State University. Although O'Brien is a cancer researcher, he has diverse scientific interests. He led the team that discovered the CCR5-Δ32 mutation that confers resistance to HIV, and he has helped document the remarkable genetic uniformity of African cheetahs. Recently, he and two California scientists started the Genome 10K project, which aims to sequence the genetic blueprints of 10,000 vertebrate species. On a trip back to the US, O'Brien spoke with Elie Dolgin about how comparative genomics and his new Russian center will help advance the search for new therapeutics. PMID:23295996

  7. Mutational analysis of the human immunodeficiency virus type 1 Eli Nef function.

    PubMed Central

    Zazopoulos, E; Haseltine, W A

    1992-01-01

    The studies presented here define an internally consistent experimental system that permits systematic analysis of the effect of nef on the rate of the human immunodeficiency virus type 1 (HIV-1) replication in a CD4+ tumor T-cell line and in primary peripheral blood mononuclear cells. The parental full-length Nef protein, derived from the Eli strain of HIV-1, accelerates virus replication in both cell types. Mutations that destabilize or alter the intracellular location of the protein affect the ability of the Nef protein to accelerate virus replication. A set of mutants was made in amino acids proposed to be required for Nef function, including threonine and serine residues proposed to be targets for phosphorylation, and in sequences thought to resemble the G-1, G-3, and G-4 sites of the family of G proteins. In most cases alterations of the critical amino acids yield stable Nef proteins of parental phenotype. These results challenge the existing theories for the mechanism of Nef function. The results also identify two residues in the carboxyl half of the protein that are important for Nef function. Images PMID:1631166

  8. Copper speciation in variably toxic sediments at the Ely Copper Mine, Vermont, United States

    USGS Publications Warehouse

    Kimball, Bryn E.; Foster, Andrea L.; Seal, Robert; Piatak, Nadine; Webb, Samuel M.; Hammarstrom, Jane M.

    2016-01-01

    At the Ely Copper Mine Superfund site, Cu concentrations exceed background values in both streamwater (160–1200 times) and sediments (15–79 times). Previously, these sediment samples were incubated with laboratory test organisms, and they exhibited variable toxicity for different stream sites. In this study we combined bulk- and microscale techniques to determine Cu speciation and distribution in these contaminated sediments on the basis of evidence from previous work that Cu was the most important stressor in this environment and that variable observed toxicity could have resulted from differences in Cu speciation. Copper speciation results were similar at microscopic and bulk scales. The major Cu species in the more toxic samples were sorbed or coprecipitated with secondary Mn (birnessite) and Fe minerals (jarosite and goethite), which together accounted for nearly 80% of the total Cu. The major Cu species in the less toxic samples were Cu sulfides (chalcopyrite and a covellite-like phase), making up about 80–95% of the total Cu, with minor amounts of Cu associated with jarosite or goethite. These Cu speciation results are consistent with the toxicity results, considering that Cu sorbed or coprecipitated with secondary phases at near-neutral pH is relatively less stable than Cu bound to sulfide at lower pH. The more toxic stream sediment sites were those that contained fewer detrital sulfides and were upstream of the major mine waste pile, suggesting that removal and consolidation of sulfide-bearing waste piles on site may not eliminate all sources of bioaccessible Cu.

  9. Copper Speciation in Variably Toxic Sediments at the Ely Copper Mine, Vermont, United States.

    PubMed

    Kimball, Bryn E; Foster, Andrea L; Seal, Robert R; Piatak, Nadine M; Webb, Samuel M; Hammarstrom, Jane M

    2016-02-01

    At the Ely Copper Mine Superfund site, Cu concentrations exceed background values in both streamwater (160-1200 times) and sediments (15-79 times). Previously, these sediment samples were incubated with laboratory test organisms, and they exhibited variable toxicity for different stream sites. In this study we combined bulk- and microscale techniques to determine Cu speciation and distribution in these contaminated sediments on the basis of evidence from previous work that Cu was the most important stressor in this environment and that variable observed toxicity could have resulted from differences in Cu speciation. Copper speciation results were similar at microscopic and bulk scales. The major Cu species in the more toxic samples were sorbed or coprecipitated with secondary Mn (birnessite) and Fe minerals (jarosite and goethite), which together accounted for nearly 80% of the total Cu. The major Cu species in the less toxic samples were Cu sulfides (chalcopyrite and a covellite-like phase), making up about 80-95% of the total Cu, with minor amounts of Cu associated with jarosite or goethite. These Cu speciation results are consistent with the toxicity results, considering that Cu sorbed or coprecipitated with secondary phases at near-neutral pH is relatively less stable than Cu bound to sulfide at lower pH. The more toxic stream sediment sites were those that contained fewer detrital sulfides and were upstream of the major mine waste pile, suggesting that removal and consolidation of sulfide-bearing waste piles on site may not eliminate all sources of bioaccessible Cu. PMID:26734712

  10. Front end for high-repetition rate thin disk-pumped OPCPA beamline at ELI-beamlines

    NASA Astrophysics Data System (ADS)

    Green, Jonathan T.; Novák, Jakub; Antipenkov, Roman; Batysta, František; Zervos, Charalampos; Naylon, Jack A.; Mazanec, TomáÅ.¡; Horáček, Martin; Bakule, Pavel; Rus, Bedřich

    2015-02-01

    The ELI-Beamlines facility, currently under construction in Prague, Czech Republic, will house multiple high power laser systems with varying pulse energies, pulse durations, and repetition rates. Here we present the status of a high repetition rate beamline currently under construction with target parameters of 20 fs pulse duration, 100 mJ pulse energy, and 1 kHz repetition rate. Specifically we present the Yb:YAG thin disk lasers which are intended to pump picosecond OPCPA, synchronization between pump and signal pulses in the OPCPA, and the first stages of OPCPA.

  11. The effect of weld porosity on the cryogenic fatigue strength of ELI grade Ti-5Al-2.5Sn

    NASA Technical Reports Server (NTRS)

    Rogers, P. R.; Lambdin, R. C.; Fox, D. E.

    1992-01-01

    The effect of weld porosity on the fatigue strength of ELI grade Ti-5Al-2.5Sn at cryogenic temperature was determined. A series of high cycle fatigue (HCF) and tensile tests were performed at -320 F on specimens made from welded sheets of the material. All specimens were tested with weld beads intact and some amount of weld offset. Specimens containing porosity and control specimens containing no porosity were tested. Results indicate that for the weld configuration tested, the fatigue life of the material is not affected by the presence of spherical embedded pores.

  12. Regulating Direct-to-Consumer Drug Information: A Case Study of Eli Lilly's Canadian 40over40 Erectile Dysfunction Campaign

    PubMed Central

    Williams-Jones, Bryn

    2015-01-01

    Like most jurisdictions, Canada prohibits direct-to-consumer advertising (DTCA) of prescribed drugs. However, direct-to-consumer information (DTCI) is permitted, allowing companies to inform the public about medical conditions. An analysis of Eli Lilly's 40over40 promotion campaign for erectile dysfunction (ED), which included a quiz on ED, shows that DTCI, like DTCA, can be an effective means of drug familiarization. The pharmaceutical industry is “playing by the rules” currently in effect in Canada. Regulators should thus seriously consider whether existing rules permitting DTCI actually meet stated objectives of protecting the public from marketing campaigns (i.e., DTCA) that may deliver misleading information. PMID:26142356

  13. Regulating Direct-to-Consumer Drug Information: A Case Study of Eli Lilly's Canadian 40over40 Erectile Dysfunction Campaign.

    PubMed

    Pipon, Jean-Christophe Bélisle; Williams-Jones, Bryn

    2015-05-01

    Like most jurisdictions, Canada prohibits direct-to-consumer advertising (DTCA) of prescribed drugs. However, direct-to-consumer information (DTCI) is permitted, allowing companies to inform the public about medical conditions. An analysis of Eli Lilly's 40over40 promotion campaign for erectile dysfunction (ED), which included a quiz on ED, shows that DTCI, like DTCA, can be an effective means of drug familiarization. The pharmaceutical industry is "playing by the rules" currently in effect in Canada. Regulators should thus seriously consider whether existing rules permitting DTCI actually meet stated objectives of protecting the public from marketing campaigns (i.e., DTCA) that may deliver misleading information. PMID:26142356

  14. C.T. Jackson's 15 October 1846 letter to J.-B.A.L. Elie de Beaumont: Jackson's thoughts on Ether Day's Eve?

    PubMed

    Bause, George S; Sim, Patrick P

    2011-01-01

    As did the previous letter on 30 November 1845 from Charles T. Jackson to J.-B.A.L. Elie de Beaumont, this 15 October 1846 missive underscores the cordial professional relationship between the two geologists. Remarkably, in this "Ether Day's Eve" letter, Jackson never reveals whether he had any clue that W.T.G. Morton would be publicly demonstrating ether anesthesia for surgery the next morning. More importantly, since Elie de Beaumont would play a future pivotal role in assigning initial credit for "discovering anesthesia" to his geological colleague Jackson, rather than to Morton, letters such as these from November of 1845 and October of 1846 can only raise more questions about the impartiality of Elie de Beaumont. PMID:22849206

  15. Nuclear Science and Applications with the Next Generation of High-Power Lasers and Brilliant Low-Energy Gamma Beams at ELI-NP

    NASA Astrophysics Data System (ADS)

    Gales, S.; ELI-NP Team

    2015-10-01

    The development of high power lasers and the combination of such novel devices with accelerator technology has enlarged the science reach of many research fields, in particular High Energy, Nuclear and Astrophysics as well as societal applications in Material Science, Nuclear Energy and Medicine. The European Strategic Forum for Research Infrastructures (ESFRI) has selected a proposal based on these new premises called "ELI" for Extreme Light Infrastructure. ELI will be built as a network of three complementary pillars at the frontier of laser technologies. The ELI-NP pillar (NP for Nuclear Physics) is under construction near Bucharest (Romania) and will develop a scientific program using two 10 PW class lasers and a Back Compton Scattering High Brilliance and Intense Low Energy Gamma Beam, a marriage of Laser and Accelerator technology at the frontier of knowledge. In the present paper, the technical and scientific status of the project as well as the applications of the gamma source will be discussed.

  16. Monte Carlo simulation of a collimation system for low-energy beamline of ELI-NP Gamma Beam System

    NASA Astrophysics Data System (ADS)

    Cardarelli, P.; Gambaccini, M.; Marziani, M.; Bagli, E.; Petrillo, V.; Bacci, A.; Curatolo, C.; Drebot, I.; Vaccarezza, C.

    2015-07-01

    ELI-nuclear physics (NP) Gamma Beam System (GBS) is an intense and monochromatic gamma beam source based on inverse Compton interaction, currently being built in Bucharest, Romania. The gamma beam produced, with energy ranging from 0.2 to 20 MeV, energy bandwidth 0.5% and flux of about 108photons/s, will be devoted to investigate a broad range of applications such as nuclear physics, astrophysics, material science and life sciences. The radiation produced by an inverse Compton interaction is not intrinsically monochromatic. In fact, the energy of the photons produced is related to the emission angle, therefore the energy bandwidth can be modified adjusting the collimation of the gamma beam. In order to define the optimal layout and evaluate the performance of a collimation system for the ELI-NP-GBS low-energy beamline (0.2-3.5 MeV), a detailed Monte Carlo simulation activity has been carried out. The simulation, using Geant4 and MCNPX codes, included the transport of the gamma beam from the interaction point to the experimental area passing through vacuum pipes, vacuum chambers, collimation system and relative shielding. The effectiveness of the collimation system, in obtaining the required energy distribution and avoiding the contamination due to secondary radiation production, was evaluated. Also, the background radiation generated by collimation and the shielding layout have been studied.

  17. Measuring GAMMA 10 end-loss ions with an ELIS (end-loss-ion spectrometers) from TMX-U

    SciTech Connect

    Foote, J.H.

    1987-09-03

    The author spent the period from March 22 to July 10, 1987, at the GAMMA 10 tandem-mirror experiment at the University of Tsukuba in Tsukuba, Japan. The purpose of this extended trip was to install on GAMMA 10 one of the end-loss-ion spectrometers (ELIS) used on TMX-U (Tandem Mirror Experiment-Upgrade) at LLNL and to make plasma measurements there with this diagnostic instrument. This report discusses the considerable planning and preparations that preceded the trip, the actual experience with the ELIS equipment at GAMMA 10, data and results obtained while the author was there, GAMMA 10 experimental procedures, the scientific and technical support during the stay, and some final comments and suggestions concerning an international exchange such as this one. The data acquired on GAMMA 10 while there, along with earlier data, present an encouraging picture of a plasma in a thermal-barrier mode in a tandem-mirror, magnetic-fusion machine. 6 refs.

  18. Effect of Test Frequency on Fatigue Crack Growth Rates of Ti-6Al-4V ELI Alloy at Cryogenic Temperature

    SciTech Connect

    Yuri, T.; Ono, Y.; Ogata, T.

    2006-03-31

    In order to clarify the effect of test frequency on the fatigue crack growth rates (da/dN) of Ti-6Al-4V ELI alloy have been investigated at cryogenic temperature. The fatigue crack growth tests were conducted using the test frequencies of 5 and 20 Hz, respectively. At 4 K, the effects of the test frequencies on the fatigue crack growth rates of Ti-6Al-4V ELI alloy were not clear or significant. The fatigue crack growth rates in the low propagation rate region at 4 K were smaller than those at 293 K. On the other hand, those in the high propagation rate region at 4 K were bigger than those at 293 K. The former is considered that the crack closure level was higher as compared to that at 293 K and the latter is due to the difference values of the fracture toughness at 4 and 293 K, respectively. The fracture surfaces of compact tension (CT) specimens in the high propagation rate regions at each test temperature revealed the striations, and furthermore accompanied with the flute fracture surface at 4 K. On the other hand, those of CT specimens in the low propagation rate region at 4 K were found facet-like fracture surfaces corresponding with almost the {alpha}-grain size.

  19. Medical research and multidisciplinary applications with laser-accelerated beams: the ELIMED netwotk at ELI-Beamlines

    NASA Astrophysics Data System (ADS)

    Tramontana, A.; Anzalone, A.; Candiano, G.; Carpinelli, M.; Cirrone, G. A. P.; Cuttone, G.; Korn, G.; Licciardello, T.; Maggiore, M.; Manti, L.; Margarone, D.; Musumarra, A.; Perozziello, F.; Pisciotta, P.; Raffaele, L.; Romano, F.; Romano, F. P.; Stancampiano, C.; Schillaci, F.; Scuderi, V.; Torrisi, L.; Tudisco, S.

    2014-04-01

    Laser accelerated proton beams represent nowadays an attractive alternative to the conventional ones and they have been proposed in different research fields. In particular, the interest has been focused in the possibility of replacing conventional accelerating machines with laser-based accelerators in order to develop a new concept of hadrontherapy facilities, which could result more compact and less expensive. With this background the ELIMED (ELIMED: ELI-Beamlines MEDical applications) research project has been launched by LNS-INFN researchers (Laboratori Nazionali del Sud-Istituto Nazionale di Fisica Nucleare, Catania, IT) and ASCR-FZU researchers (Academy of Sciences of the Czech Republic-Fyzikální ústar, Prague, Cz), within the pan-European ELI-Beamlines facility framework. Its main purposes are the demonstration of future applications in hadrontherapy of optically accelerated protons and the realization of a laser-accelerated ion transport beamline for multidisciplinary applications. Several challenges, starting from laser-target interaction and beam transport development, up to dosimetric and radiobiological issues, need to be overcome in order to reach the final goals. The design and the realization of a preliminary beam handling and dosimetric system and of an advanced spectrometer for high energy (multi-MeV) laser-accelerated ion beams will be shortly presented in this work.

  20. Selected Water- and Sediment-Quality, Aquatic Biology, and Mine-Waste Data from the Ely Copper Mine Superfund Site, Vershire, VT, 1998-2007

    USGS Publications Warehouse

    Argue, Denise M.; Kiah, Richard G.; Piatak, Nadine M.; Seal, Robert R., II; Hammarstrom, Jane M.; Hathaway, Edward; Coles, James F.

    2008-01-01

    The data contained in this report are a compilation of selected water- and sediment-quality, aquatic biology, and mine-waste data collected at the Ely Copper Mine Superfund site in Vershire, VT, from August 1998 through May 2007. The Ely Copper Mine Superfund site is in eastern, central Vermont (fig. 1) within the Vermont Copper Belt (Hammarstrom and others, 2001). The Ely Copper Mine site was placed on the U.S. Environmental Protection Agency (USEPA) National Priorities List in 2001. Previous investigations conducted at the site documented that the mine is contributing metals and highly acidic waters to local streams (Hammarstrom and others, 2001; Holmes and others, 2002; Piatak and others, 2003, 2004, and 2006). The U.S. Geological Survey (USGS), in cooperation with the USEPA, compiled selected data from previous investigations into uniform datasets that will be used to help characterize the extent of contamination at the mine. The data may be used to determine the magnitude of biological impacts from the contamination and in the development of remediation activities. This report contains analytical data for samples collected from 98 stream locations, 6 pond locations, 21 surface-water seeps, and 29 mine-waste locations. The 98 stream locations are within 3 streams and their tributaries. Ely Brook flows directly through the Ely Copper Mine then into Schoolhouse Brook (fig. 2), which joins the Ompompanoosuc River (fig. 1). The six pond locations are along Ely Brook Tributary 2 (fig. 2). The surface-water seeps and mine-waste locations are near the headwaters of Ely Brook (fig. 2 and fig. 3). The datasets 'Site_Directory' and 'Coordinates' contain specific information about each of the sample locations including stream name, number of meters from the mouth of stream, geographic coordinates, types of samples collected (matrix of sample), and the figure on which the sample location is depicted. Data have been collected at the Ely Copper Mine Superfund site by the

  1. Surface Quality of Ti-6%Al-4%V ELI When Machined Using CVD-Carbide Tools at High Cutting Speed

    SciTech Connect

    Gusri, A. I.; Che Hassan, C. H.; Jaharah, A. G.; Yasir, A.; Zaid, Y.; Yanuar, B.

    2011-01-17

    Machining of Ti-6Al-4V ELI becomes more interested topic due to extremely weight-to-strength ratio and resistance to corrosion at elevated temperature. Quality of machined surface is presented by surface roughness, surface texture and damages of microstructure of titanium alloys. The turning parameters evaluated are cutting speed of 55-95 m/min, feed rate of 0.15-0.35 mm/rev, depth of cut of 0.10-0.20 mm and tool grade of CVD carbide tools. The results show the trend lines of surface roughness value are higher at the initial machining and the surface texture profile has a strong correlation with the feed rate. At the machining condition of cutting speed of 95 m/min, feed rate of 0.35 mm/rev and depth of cut of 0.10 mm produced the with layer with thickness of 2.0 {mu}m.

  2. Future laser-accelerated proton beams at ELI-Beamlines as potential source of positron emitters for PET

    NASA Astrophysics Data System (ADS)

    Amato, E.; Italiano, A.; Margarone, D.; Pagano, B.; Baldari, S.; Korn, G.

    2016-04-01

    The development of novel compact PET radionuclide production systems is of great interest to promote the diffusion of PET diagnostics, especially in view of the continuous development of novel, fast and efficient, radiopharmaceutical methods of labeling. We studied the feasibility to produce clinically-relevant amounts of PET isotopes by means of laser-accelerated proton sources expected at the ELI-Beamlines facility where a PW, 30 fs, 10 Hz laser system will be available. The production yields of several positron emitters were calculated through the TALYS software, by taking into account three possible scenarios of broad proton spectra expected, with maximum energies ranging from about 8 MeV to 100 MeV. With the hypothesized proton fluencies, clinically-relevant amounts of radionuclides can be obtained, suitable to prepare single doses of radiopharmaceuticals exploiting modern fast and efficient labeling systems.

  3. Laser Assisted Milling of Ti-6Al-4V ELI with the Analysis of Surface Integrity and its Economics

    NASA Astrophysics Data System (ADS)

    Hedberg, Gary K.; Shin, Yung C.

    2015-09-01

    This study presents the experimental evaluation of laser assisted milling (LAML) of Ti-6AL-4V ELI (Ti-64), which is used in the orthopedic industry, by using localized preheating of the workpiece via laser irradiation. Improvements to the machinability of this material with LAML are assessed while considering the surface integrity. Suitable laser heating conditions as well as machining conditions are determined based on temperature prediction modeling. Machinability improvements are shown in terms of tool wear, material removal rates and cutting force reduction. Systematic characterization of samples is shown to demonstrate that the machined sub-surfaces are not adversely affected during LAML by precisely controlling laser heating, via hardness measurements, scanning electron microscopy (SEM) for microstructure analysis, and X-ray diffraction (XRD) for residual stresses. An economic analysis shows that LAML provides the cost reduction over conventional machining.

  4. High-cycle fatigue behavior of Ti-5Al-2.5Sn ELI alloy forging at low temperatures

    SciTech Connect

    Ono, Yoshinori; Yuri, Tetsumi; Ogata, Toshio; Demura, Masahiko; Matsuoka, Saburo; Sunakawa, Hideo

    2014-01-27

    High-cycle fatigue properties of Ti-5Al-2.5Sn Extra Low Interstitial (ELI) alloy forging were investigated at low temperatures. The high-cycle fatigue strength at low temperatures of this alloy was relatively low compared with that at ambient temperature. The crystallographic orientation of a facet formed at a fatigue crack initiation site was determined by electron backscatter diffraction (EBSD) method in scanning electron microscope (SEM) to understand the fatigue crack initiation mechanism and discuss on the low fatigue strength at low temperature. Furthermore, in terms of the practical use of this alloy, the effect of the stress ratio (or mean stress) on the high-cycle fatigue properties was evaluated using the modified Goodman diagram.

  5. Investigation of the d(γ,n)p reaction for gamma beam monitoring at ELI-NP

    NASA Astrophysics Data System (ADS)

    Matei, C.; Mueller, J. M.; Sikora, M. H.; Suliman, G.; Ur, C. A.; Weller, H. R.

    2016-05-01

    The Extreme Light Infrastructure - Nuclear Physics facility will deliver brilliant gamma beams with high spectral density and a high degree of polarization starting in 2018 in Bucharest-Magurele, Romania. Several monitoring instruments are proposed for measuring the spectral, temporal, and spatial characteristics of the gamma beam. The d(γ,n)p reaction has been investigated for its use in determining the gamma beam parameters in a series of measurements carried out at the High Intensity Gamma Source, Durham, U.S.A.. Measurements of the emitted neutrons have been performed using liquid scintillator and 6Li-glass neutron detectors at several incident gamma energies between 2.5 to 20 MeV . The experimental results presented in this paper have shown that an instrument based on the d(γ,n)p reaction can be used to monitor the intensity and polarization of the gamma beam to be produced at ELI-NP.

  6. High-cycle fatigue behavior of Ti-5Al-2.5Sn ELI alloy forging at low temperatures

    NASA Astrophysics Data System (ADS)

    Ono, Yoshinori; Yuri, Tetsumi; Ogata, Toshio; Demura, Masahiko; Matsuoka, Saburo; Sunakawa, Hideo

    2014-01-01

    High-cycle fatigue properties of Ti-5Al-2.5Sn Extra Low Interstitial (ELI) alloy forging were investigated at low temperatures. The high-cycle fatigue strength at low temperatures of this alloy was relatively low compared with that at ambient temperature. The crystallographic orientation of a facet formed at a fatigue crack initiation site was determined by electron backscatter diffraction (EBSD) method in scanning electron microscope (SEM) to understand the fatigue crack initiation mechanism and discuss on the low fatigue strength at low temperature. Furthermore, in terms of the practical use of this alloy, the effect of the stress ratio (or mean stress) on the high-cycle fatigue properties was evaluated using the modified Goodman diagram.

  7. Complex modes of bonding: NCI/ELI-D vs. DORI surface analyses of hapticities and hydrogen-hydrogen contacts in zincocene related compounds

    NASA Astrophysics Data System (ADS)

    Mebs, Stefan

    2016-05-01

    Atoms-in-molecules (AIM) topology is prone to wrong/ambiguous bond assignments (lacking bond critical points) in areas of low electron densities (ED), e.g. for hydrogen-hydrogen contacts, and flat density gradients, e.g. for metal-ring contacts (hapticities), both in experimental and computed ED. Within this study, two ED-derived bonding indicators are applied to a set of zincocene related compounds: non-covalent interactions (NCI) surfaces are combined with electron localizability indicator (ELI-D) surfaces and compared to density overlap regions indicator (DORI) surfaces. Both methods (NCI/ELI-D, DORI) result in spatial deconvolution of covalent and non-covalent interactions and unravel weak interactions not observed in the AIM topology.

  8. Regional soil-gas helium distribution of the Ely and Delta 1° x 2° quadrangles, Basin and Range Province

    USGS Publications Warehouse

    Reimer, G.M.; Bowles, C.G.

    1990-01-01

    A reconnaissance soil-gas helium survey was made in the Ely, Nevada and Delta, Utah 1° × 2° quadrangles in the Basin and Range Province. Helium concentrations in 510 samples ranged from −147 to 441 ppb He with respect to ambient air. The median helium value for the study area was 36 ppb. Concentrations of more than 100 ppb He and less than −20 ppb He occur more commonly in the Ely quadrangle and are especially numerous in the western one-half of this quadrangle. Interpretation of the data reveals that the helium concentrations reflect the rock type, particularly the silicic volcanic occurrences, and the geological structure of the area created by crustal extension. The regional soil-gas helium distribution is important information to consider when interpreting anomalies from detailed surveys.

  9. High and low energy gamma beam dump designs for the gamma beam delivery system at ELI-NP

    NASA Astrophysics Data System (ADS)

    Yasin, Zafar; Matei, Catalin; Ur, Calin A.; Mitu, Iani-Octavian; Udup, Emil; Petcu, Cristian

    2016-03-01

    The Extreme Light Infrastructure - Nuclear Physics (ELI-NP) is under construction in Magurele, Bucharest, Romania. The facility will use two 10 PW lasers and a high intensity, narrow bandwidth gamma beam for stand-alone and combined laser-gamma experiments. The accurate estimation of particle doses and their restriction within the limits for both personel and general public is very important in the design phase of any nuclear facility. In the present work, Monte Carlo simulations are performed using FLUKA and MCNPX to design 19.4 and 4 MeV gamma beam dumps along with shielding of experimental areas. Dose rate contour plots from both FLUKA and MCNPX along with numerical values of doses in experimental area E8 of the facility are performed. The calculated doses are within the permissible limits. Furthermore, a reasonable agreement between both codes enhances our confidence in using one or both of them for future calculations in beam dump designs, radiation shielding, radioactive inventory, and other calculations releated to radiation protection. Residual dose rates and residual activity calculations are also performed for high-energy beam dump and their effect is negligible in comparison to contributions from prompt radiation.

  10. Source of slow polarized positrons using the brilliant gamma beam at ELI-NP. Converter design and simulations

    NASA Astrophysics Data System (ADS)

    Djourelov, Nikolay; Oprisa, Andreea; Leca, Victor

    2016-01-01

    Simulations of slow positron (es+) source based on interaction of a circularly polarized gamma beam with a W converter were performed. The aim of the study was to propose a converter geometry and to determine the expected slow positron beam intensity and its spot size, and the degree of positron spin polarization, as well. The Monte Carlo simulations by means of GEANT4 were used to estimate the fast positron production and the moderation efficiency of the converter working as a self-moderator, as well. Finite element analysis by means of COMSOL Multiphysics was applied to calculate the fraction of extracted moderated positrons from the converter cells and the quality of the beam formation by focusing. Using the low energy (<3.5 MeV) gamma beam at ELI-NP with intensity of 2.4×1010γ/s the production of a slow positron beam with intensity of 1-2×106 es+/s is predicted. For the optimized converter geometry and in case of 100% circular polarization of the gammas the degree of spin polarization of the slow positron beam is expected to be 33%.

  11. Gene expression of human osteoblasts cells on chemically treated surfaces of Ti-6Al-4V-ELI.

    PubMed

    Oliveira, D P; Palmieri, A; Carinci, F; Bolfarini, C

    2015-06-01

    Surface modifications of titanium alloys are useful methods to enhance the biological stability of intraosseous implants and to promote a well succeeded osseointegration in the early stages of implantation. This work aims to investigate the influence of chemically modified surfaces of Ti-6Al-4V-ELI (extra-low interstitial) on the gene expression of human osteoblastic (HOb) cells. The surface treatments by acid etching or acid etching plus alkaline treatment were carried out to modify the topography, effective area, contact angle and chemical composition of the samples. The surface morphology was investigated using: scanning electron microscopy (SEM) and confocal laser-scanning microscope (CLSM). Roughness measurements and effective surface area were obtained using the CLSM. Surface composition was analysed by energy dispersive X-ray spectroscopy (EDX) and by X-Ray Diffraction (XRD). The expression levels of some bone related genes (ALPL, COL1A1, COL3A1, SPP1, RUNX2, and SPARC) were analysed using real-time Reverse Transcription Polymerase Chain Reaction (real-time RT-PCR). The results showed that all the chemical modifications studied in this work influenced the surface morphology, wettability, roughness, effective area and gene expression of human osteoblasts. Acid phosphoric combined to alkaline treatment presented a more accelerated gene expression after 7days while the only phosphoric etching or chloride etching combined to alkaline treatment presented more effective responses after 15days. PMID:25842132

  12. Nuclear Science and Applications with the Next Generation of High-Power Lasers and Brilliant Low-Energy Gamma Beams at ELI-NP

    NASA Astrophysics Data System (ADS)

    Gales, S.

    The development of high power lasers and the combination of such novel devices with accelerator technology has enlarged the science reach of many research fields, in particular Particle and Nuclear Physics, Astrophysics as well as societal applications in Material Science, Nuclear Energy and Medicine. The European Strategic Forum for Research Infrastructures (ESFRI) has selected a proposal based on these new premises called "ELI" for Extreme Light Infrastructure. ELI will be built as a network of three complementary pillars at the frontier of laser technologies. The ELI-NP pillar (NP for Nuclear Physics) is under construction near Bucharest (Romania) and will develop a scientific program using two 10 PW lasers and a Compton back-scattering high-brilliance and intense low-energy gamma beam, a marriage of laser and accelerator technology at the frontier of knowledge. In the present paper, the technical description of the facility, the present status of the project as well as the science, applications and future perspectives will be discussed.

  13. Nuclear Science and Applications with the Next Generation of High-Power Lasers and Brilliant Low-Energy Gamma Beams at ELI-NP

    NASA Astrophysics Data System (ADS)

    Gales, S.

    2015-11-01

    The development of high-power lasers and the combination of such novel devices with accelerator technology has enlarged the science reach of many research fields, in particular high-energy nuclear physics and astrophysics, as well as societal applications in material science, nuclear energy and medicine. The European Strategic Forum for Research Infrastructures (ESFRI) has selected a proposal based on these new premises called "ELI" for Extreme Light Infrastructure. ELI will be built as a network of three complementary pillars at the frontier of laser technologies. The ELI-NP pillar (NP for nuclear physics) is under construction near Bucharest (Romania) and will develop a scientific program using two 10-PW lasers and a Compton back-scattering high-brilliance and intense low-energy gamma beam, a marriage of laser and accelerator technology at the frontier of knowledge. In the present paper, the technical description of the facility, the present status of the project as well as the science, applications and future perspectives will be discussed.

  14. [ELIE METCHNIKOFF--THE FOUNDER OF LONGEVITY SCIENCE AND A FOUNDER OF MODERN MEDICINE: IN HONOR OF THE 170TH ANNIVERSARY].

    PubMed

    Stambler, I S

    2015-01-01

    The years 2015-2016 mark a double anniversary--the 170th anniversary of birth and the 100th anni- versary of death--of one of the greatest Russian scientists, a person that may be considered a founding figure of modern immunology, aging and longevity science--Elie Metchnikoff (May 15, 1845-July 15, 1916). At this time of the rapid aging of the world population and the rapid development of technologies that may ameliorate degenerative aging processes, Metchnikoff's pioneering contribution to the search for anti-aging and healthspan-extending means needs to be recalled and honored. PMID:26856081

  15. Data Sheet Program and Mechanical Properties of Ti-5Al-2.5Sn ELI and Alloy 718 at Cryogenic Temperatures

    SciTech Connect

    Ogata, T.; Yuri, T.; Sumiyoshi, H.; Ono, Y.; Matsuoka, S.; Okita, K.

    2004-06-28

    In the development of Japan's self-developed H-IIA launch vehicle, it is important to sufficiently comprehend the properties of materials under conditions in which the materials are used in the system for its design and the improvement of its reliability. Through the process of failure analysis of the LE-7 engine of H-II No. 8 in 1999, detailed materials data and photographs of the fracture surface were required as reference data to determine in terms of fracture morphology and to analyze the fracture stress. A series of mechanical properties tests, such as tensile tests, impact tests, fracture toughness tests, and fatigue tests, on Ti-5Al-2.5Sn ELI and Alloy 718 at room temperature to 4K were mainly conducted by NIMS and NASDA. The obtained tensile and fracture toughness properties were a little bit smaller than those reported by NASA and NRIM, however, the fatigue properties were relatively lower than the data reported so far. Data resulting from the tests were reviewed in detail and published in the form of data sheets. This paper will introduce the data sheet program on space use materials and discuss an effect of microstructure of Ti-5Al-2.5Sn ELI and Alloy 718 on their mechanical properties at cryogenic temperatures.

  16. Data Sheet Program and Mechanical Properties of Ti-5Al-2.5Sn ELI and Alloy 718 at Cryogenic Temperatures

    NASA Astrophysics Data System (ADS)

    Ogata, T.; Yuri, T.; Sumiyoshi, H.; Ono, Y.; Matsuoka, S.; Okita, K.

    2004-06-01

    In the development of Japan's self-developed H-IIA launch vehicle, it is important to sufficiently comprehend the properties of materials under conditions in which the materials are used in the system for its design and the improvement of its reliability. Through the process of failure analysis of the LE-7 engine of H-II No. 8 in 1999, detailed materials data and photographs of the fracture surface were required as reference data to determine in terms of fracture morphology and to analyze the fracture stress. A series of mechanical properties tests, such as tensile tests, impact tests, fracture toughness tests, and fatigue tests, on Ti-5Al-2.5Sn ELI and Alloy 718 at room temperature to 4K were mainly conducted by NIMS and NASDA. The obtained tensile and fracture toughness properties were a little bit smaller than those reported by NASA and NRIM, however, the fatigue properties were relatively lower than the data reported so far. Data resulting from the tests were reviewed in detail and published in the form of data sheets. This paper will introduce the data sheet program on space use materials and discuss an effect of microstructure of Ti-5Al-2.5Sn ELI and Alloy 718 on their mechanical properties at cryogenic temperatures.

  17. Theoretical QTAIM, ELI-D, and Hirshfeld surface analysis of the Cu-(H)B interaction in [Cu2(bipy)2B10H10].

    PubMed

    Vologzhanina, Anna V; Korlyukov, Alexander A; Avdeeva, Varvara V; Polyakova, Irina N; Malinina, Elena A; Kuznetsov, Nikolai T

    2013-12-12

    Interaction of [Cu2B10H10] with 2,2'-bipyridine (bipy) afforded a novel binuclear discrete complex of the [Cu2(bipy)2B10H10] composition. Two copper(I) atoms coordinate a bridge boron cage through an apical edge and a triangular BBB face situated at its opposite apical vertices to form four 3c2e (CuHB) and one 2c2e Cu-B bonds. The charge density model was obtained by density functional theory calculations of isolated molecule and crystal. The resultant densities were analyzed using the quantum theory of atoms in molecules (QTAIM) and electron localizability indicator (ELI-D). The geometry and the topological parameters of copper(I) coordination environment were found to be sensitive to crystal-field effect. An annulus of flat electron density ρ(r) and small ∇(2)ρ(r) is formed at dianion faces. As a result, some of the expected B-B, Cu-B, or Cu-H bond critical points are absent. The topological instability in the region of multicentered bonds is observed. The Cu-B bonding was found to be presumably electrostatic in nature, which could be the reason of topological isomerism for copper(I) decaborates. The results show that an unambiguous real-space criterion for multicentered bonding between transition metals and polyhedral boron anions is not yet given. The molecular graph for this class of compounds does not provide a definitive picture of the chemical boding and can be complemented with other descriptors, such as virial graphs and the ELI-D distribution. PMID:24200215

  18. Geochemical characterization of slags, other mines wastes, and their leachates from the Elizabeth and Ely mines (Vermont), the Ducktown mining district (Tennessee), and the Clayton smelter site (Idaho)

    USGS Publications Warehouse

    Piatak, Nadine M.; Seal, Robert R., II; Hammarstrom, Jane M.; Meier, Allen L.; Briggs, Paul H.

    2003-01-01

    Waste-rock material produced at historic metal mines contains elevated concentrations of potentially toxic trace elements. Two types of mine waste were examined in this study: sintered waste rock and slag. The samples were collected from the Elizabeth and Ely mines in the Vermont copper belt (Besshi-type massive sulfide deposits), from the Copper Basin mining district near Ducktown, Tennessee (Besshi-type massive sulfide deposits), and from the Clayton silver mine in the Bayhorse mining district, Idaho (polymetallic vein and replacement deposits). The data in this report are presented as a compilation with minimal interpretation or discussion. A detailed discussion and interpretation of the slag data are presented in a companion paper. Data collected from sintered waste rock and slag include: (1) bulk rock chemistry, (2) mineralogy, (3) and the distribution of trace elements among phases for the slag samples. In addition, the reactivity of the waste material under surficial conditions was assessed by examining secondary minerals formed on slag and by laboratory leaching tests using deionized water and a synthetic solution approximating precipitation in the eastern United States.

  19. Wear Mechanism of Chemical Vapor Deposition (CVD) Carbide Insert in Orthogonal Cutting Ti-6Al-4V ELI at High Cutting Speed

    SciTech Connect

    Gusri, A. I.; Che Hassan, C. H.; Jaharah, A. G.

    2011-01-17

    The performance of Chemical Vapor Deposition (CVD) carbide insert with ISO designation of CCMT 12 04 04 LF, when turning titanium alloys was investigated. There were four layers of coating materials for this insert i.e.TiN-Al2O3-TiCN-TiN. The insert performance was evaluated based on the insert's edge resistant towards the machining parameters used at high cutting speed range of machining Ti-6Al-4V ELI. Detailed study on the wear mechanism at the cutting edge of CVD carbide tools was carried out at cutting speed of 55-95 m/min, feed rate of 0.15-0.35 mm/rev and depth of cut of 0.10-0.20 mm. Wear mechanisms such as abrasive and adhesive were observed on the flank face. Crater wear due to diffusion was also observed on the rake race. The abrasive wear occurred more at nose radius and the fracture on tool were found at the feed rate of 0.35 mm/rev and the depth of cut of 0.20 mm. The adhesion wear takes place after the removal of the coating or coating delaminating. Therefore, adhesion or welding of titanium alloy onto the flank and rake faces demonstrates a strong bond at the workpiece-tool interface.

  20. News Conference: Bloodhound races into history Competition: School launches weather balloon Course: Update weekends inspire teachers Conference: Finland hosts GIREP conference Astronomy: AstroSchools sets up schools network to share astronomy knowledge Teaching: Delegates praise science events in Wales Resources: ELI goes from strength to strength International: South Sudan teachers receive training Workshop: Delegates experience universality

    NASA Astrophysics Data System (ADS)

    2011-11-01

    Conference: Bloodhound races into history Competition: School launches weather balloon Course: Update weekends inspire teachers Conference: Finland hosts GIREP conference Astronomy: AstroSchools sets up schools network to share astronomy knowledge Teaching: Delegates praise science events in Wales Resources: ELI goes from strength to strength International: South Sudan teachers receive training Workshop: Delegates experience universality

  1. Study of the production yields of 18F, 11C, 13N and 15O positron emitters from plasma-laser proton sources at ELI-Beamlines for labeling of PET radiopharmaceuticals

    NASA Astrophysics Data System (ADS)

    Amato, Ernesto; Italiano, Antonio; Margarone, Daniele; Pagano, Benedetta; Baldari, Sergio; Korn, Georg

    2016-03-01

    The development of novel compact PET radionuclide production systems is of great interest to promote the diffusion of PET diagnostics, especially in view of the continuous development of microfluidics labeling approaches. We studied the feasibility to produce clinically-relevant amounts of PET isotopes by means of laser-accelerated proton sources such that expected at the ELI-Beamlines facility. 18F, 11C, 13N and 15O production yields were calculated through the TALYS software, by taking into account the broad proton spectra expected. With the hypothesized proton fluencies, clinically-relevant amounts of radionuclides can be obtained, suitable to prepare single doses of 18F-, 11C- and 13N-labeled radiopharmaceuticals exploiting fast and efficient microfluidic labeling systems.

  2. Project ELI: Improving Early Literacy Outcomes

    ERIC Educational Resources Information Center

    Young, Robin Miller; Chandler, Lynette K.; Shields, LuAnn; Laubenstein, Pam; Butts, Jill; Black, Kristine

    2008-01-01

    Early childhood and elementary-level educators are engaging in conversations about how to coordinate their efforts to develop fluent readers. There is evidence that key early literacy skills that are predictive of subsequent literacy achievement in kindergarten and first grade can be taught to preschool-age children. Moreover, early childhood…

  3. Positronium formation in Ss state in e+-Li scattering

    NASA Technical Reports Server (NTRS)

    Sarkar, K. P.; Basu, D.; Basu, Madhumita

    1990-01-01

    There are ample theoretical reasons to investigate positron-alkali atom scattering. Moreover, recent measurement on positron-alkali atom system by a Detroit group has renewed much interest in investigating these processes. Positronium (Ps) formation in excited 2s state in positron-Li scattering at intermediate and high energies were studied including second order effects following Basu and Ghosh.

  4. Final EDP Ti: sapphire amplifiers for ELI project

    NASA Astrophysics Data System (ADS)

    Chvykov, Vladimir; Kalashnikov, Mikhail; Osvay, Károly

    2015-05-01

    Recently several ultrahigh intensity Chirped Pulse Amplification (CPA) laser systems have reached petawatt output powers [1, 2] setting the next milestone at tens or even hundreds petawatts for the next three to ten years [3, 4]. These remarkable results were reached when laser amplifiers (opposite to Optical Parametric Amplification (OPA) [5]) were used as final ones and from them Ti:Sapphire crystals supposed to be the working horses as well in the future design of these laser systems. Nevertheless, the main limitation that arises on the path toward ultrahigh output power and intensity is the restriction on the pumping and extraction energy imposed by Transverse Amplified Spontaneous Emission (TASE) [6] and/or transverse parasitic generation (TPG) [7] within the large aperture of the disc-shape amplifier volume.

  5. High power femtosecond lasers at ELI-NP

    SciTech Connect

    Dabu, Razvan

    2015-02-24

    Specifications of the high power laser system (HPLS) designed for nuclear physics experiments are presented. Configuration of the 2 × 10 PW femtosecond laser system is described. In order to reach the required laser beam parameters, advanced laser techniques are proposed for the HPLS: parametric amplification and cross-polarized wave generation for the intensity contrast improvement and spectral broadening, acousto-optic programmable filters to compensate for spectral phase dispersion, optical filters for spectrum management, combined methods for transversal laser suppression.

  6. Photo-fusion reactions in a new compact device for ELI

    NASA Astrophysics Data System (ADS)

    Moustaizis, S. D.; Auvray, P.; Hora, H.; Lalousis, P.; Larour, J.; Mourou, G.

    2012-07-01

    In the last few years significant progress on technological, experimental and numerical studies on fusion process in high density and high temperature plasmas produced by a high intensity laser pulse interaction with clusters in a high external applied magnetic field, enable us to propose a compact photo-fusion magnetic device for high neutron production. For the purpose of the project a pulsed magnetic field driver with values up to 110 Tesla has been developed which allows increasing the trapping time of the high density plasma in the device and improving the neutron yield. Numerical simulations show that the proposed device is capable of producing up to 109-1010 neutrons per laser shot with an external magnetic field of 150 Tesla. The proposed device can be used for experiments and numerical code validation concerning different conventional and (or) exotic fusion fuels.

  7. Telling the Tale: Sharing Elie Wiesel's "Night" with Middle School Readers.

    ERIC Educational Resources Information Center

    Hernandez, Alexander A.

    2001-01-01

    Describes how as part of a nine-week unit on tolerance and prejudice, the author's middle school students became immersed in Holocaust literature. Notes that the theme of bearing witness, of never forgetting, which runs through the literature, is the central driving force of work in the classroom. (SG)

  8. 75 FR 81190 - Television Broadcasting Services; Vernal and Santaquin, UT, and Ely and Caliente, NV

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-27

    ... 14, 2010, and released December 15, 2010. The full text of this document is available for public.... The Commission was required by the DTV Delay Act to ] terminate all licenses for full-power television stations and broadcasting by full power stations in the analog service by June 13, 2009. Therefore,...

  9. Photo-fusion reactions in a new compact device for ELI

    SciTech Connect

    Moustaizis, S. D.; Auvray, P.; Hora, H.; Lalousis, P.; Larour, J.; Mourou, G.

    2012-07-09

    In the last few years significant progress on technological, experimental and numerical studies on fusion process in high density and high temperature plasmas produced by a high intensity laser pulse interaction with clusters in a high external applied magnetic field, enable us to propose a compact photo-fusion magnetic device for high neutron production. For the purpose of the project a pulsed magnetic field driver with values up to 110 Tesla has been developed which allows increasing the trapping time of the high density plasma in the device and improving the neutron yield. Numerical simulations show that the proposed device is capable of producing up to 10{sup 9}-10{sup 10} neutrons per laser shot with an external magnetic field of 150 Tesla. The proposed device can be used for experiments and numerical code validation concerning different conventional and (or) exotic fusion fuels.

  10. Effects of hydrogen on ELI titanium alloy Ti-5Al-2.5Sn

    NASA Technical Reports Server (NTRS)

    Chandler, W. T.; Hensley, W. E.

    1970-01-01

    Tensile tests on titanium alloy, following abrasion under hydrogen and temperature cycling, reveal lowered tensile strength, increased ductility, and no embrittlement. Fretting the metal on itself in flowing hydrogen or abrading with an iron file in flowing hydrogen produces titanium hydride.

  11. Premium quality 5A1-2.5 Sn ELI titanium production

    NASA Technical Reports Server (NTRS)

    Dessau, P. P.; Harris, C. L.

    1972-01-01

    Preliminary design and reliability analysis conducted on the turbopump for the NERVA 75,000 full flow cycle engine, indicated that the turbopump bearings were the most critical turbopump parts in meeting the 10 hour life at the required turbopump reliability of .99978. The analysis revealed that significant reductions (approximately a factor of 3.25) in bearing loads would be achieved by fabricating the rotating parts from titanium in lieu of A286 or 718. This is basically due to the difference in density of the materials and the resulting mass effect on the location of the first and second stick mode critical speeds. For the selected rotor configuration, the lighter material has a first critical speed at approximately 36,000 rpm, while that of the heavier material has a first critical at approximately 27,000 rpm. As the operating range of the turbopump is from 0 to 30,000 rpm, the heavier material would have a stick mode critical in the operating range.

  12. DEMONSTRATION BULLETIN: THE ECO LOGIC THERMAL DESORPTION UNIT - MIDDLEGROUND LANDFILL - BAY CITY, MI - ELI ECO LOGIC INTERNATIONAL, INC.

    EPA Science Inventory

    ECO Logic has developed a thermal desorption unit 0"DU) for the treatment of soils contaminated with hazardous organic contaminants. This TDU has been designed to be used in conjunction with Eco Logic's patented gas-phase chemical reduction reactor. The Eco Logic reactor is the s...

  13. 78 FR 33426 - Eli Lilly and Co.; Withdrawal of Approval of a New Drug Application for ORAFLEX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-04

    ... Administration (FDA) is withdrawing approval of a new drug application (NDA) for ORAFLEX (benoxaprofen) Tablets... (benoxaprofen) Tablets, a nonsteroidal ] anti-inflammatory drug indicated for the treatment of arthritis. On August 4, 1982, Lilly voluntarily withdrew ORAFLEX (benoxaprofen) Tablets from the market because...

  14. Using Movies in EFL Classrooms: A Study Conducted at the English Language Institute (ELI), King Abdul-Aziz University

    ERIC Educational Resources Information Center

    Kabooha, Raniah Hassen

    2016-01-01

    The present study sought to examine the attitudes of Saudi English as a foreign language (EFL) learners as well as teachers towards the integration of English movies in their classes as a tool to develop students' language skills. Fifty female intermediate level students studying English in their Preparatory Year Program (PYP) in the English…

  15. Comment on: ``Chaos in the Showalter-Noyes-Bar-Eli model of the Belousov-Zhabotinskii reaction''

    NASA Astrophysics Data System (ADS)

    Györgyi, László; Field, Richard J.

    1990-08-01

    The recent numerical work of Lindberg et al. convincingly demonstrates that chemical chaos in a continuous flow, stirred tank reactor (CSTR) can be reproduced by a spatially homogeneous, accurate model of the kinetics of the Belousov-Zhabotinskii(BZ) reaction. However, some problems remain. The chaos in this model and two others, one using an accurate model of the chemical kinetics in conjunction with spatial inhomogeneity resulting from the finite CSTR mixing time and the other using a flawed model of the BZ chemical kinetics, results from coupling of two cycles coexisting within the complex dynamic model. The second cycle in the case of the homogeneous models involves a product of the main chemical limit cycle which is present at a high average concentration. In the Lindberg et al. model this product is assumed to be HOBr. It is clear, however, that a large [HOBr] does not accumulate in the real system because of its rapid reaction with Br-. We suggest that while the Lindberg et al. results are clearly important, this process still needs to be accounted for. Furthermore, the rate parameter values used by Lindberg et al. are not those currently thought to be correct, and the chaos disappears if the accurate rate constant values are used. We discuss why this is so. It is further argued that the Lindberg et al. results do not eliminate the possibility that at least part of the experimentally observed CSTR chaos results from effects related to incomplete mixing.

  16. Fatigue crack growth of Ti-6Al-4V-0.1Ru (ELI grade) in ocean environments

    NASA Astrophysics Data System (ADS)

    Langoy, Morten Andre

    1999-11-01

    This study of fatigue crack growth rates found that Ti-6Al-4V-0.1Ru alloy seamless pipe in beta transformed/annealed condition is well suited for dynamically loaded risers, which transport the reservoir fluid (oil and gas) from the well to the vessel, and promises significant economic benefits can be realized by employing the material in this application. The tested ocean environments did not detrimentally affect crack growth rates. The material was studied in two conditions: as-received (i.e., the parent material) and cold rolled (simulating the effect of coiling and reeling). The effect of different combinations of loading and environment on fatigue crack growth rates of the parent and cold rolled materials were studied systematically using a design of experiments (DOE) approach. Different combinations of temperature, load frequency, R (sigmamin/sigmamax of the fatigue cycle), pre-strain (cold work), and environment (laboratory air and aerated and deaerated simulated ocean water) were used in the study. The observed fatigue crack growth rates ranged from 4 x 10 -10 to 1 x 10-6 m/cycle and the investigated DeltaK's (stress intensity ranges) ranged from 7 to 45 MPa√m. Fatigue crack growth rates are not substantially higher in ocean environments than in air, but the differences appear to be real. Cold work (5% reduction in thickness by rolling) reduces fatigue crack growth rates (compared to the parent material) at intermediate and high DeltaK by a factor of two. Microstructure, fracture surfaces, and crack path also were related to testing conditions. Fracture surfaces reveal a change of morphology from features associated with microstructure-sensitive crack propagation (cyclic cleavage) to features (striations) linked with structure-insensitive (continuum-mode) growth. Contrary to expectations based on anecdotal accounts, crack branching is observed at the center of the samples regardless of DeltaK or other parameters and also on the outer surfaces of the compact tension samples. The branching was more prominent, however, below the transition DeltaK described above. A design of experiments (DOE) approach was used to identify loading and environmental parameters affecting fatigue crack growth for further study. The initial DOE experiment were followed by supplementary tests investigating the effects predicted by the initial results; ie., verifying the approach. The results demonstrated that the DOE approach offers considerable advantage.

  17. Behavior of Ti-5Al-2.5Sn ELI titanium alloy sheet parent and weld metal in the presence of cracks at 20 K

    NASA Technical Reports Server (NTRS)

    Sullivan, T. L.

    1971-01-01

    Through- and surface-cracked specimens of two thicknesses were tested in uniaxial tension. Surface-cracked specimens were generally found to be stronger than through-cracked specimens with the same crack length. Apparent surface-crack fracture toughness calculated using the Anderson modified Irwin equation remained relatively constant for cracks as deep as 90 percent of the sheet thickness. Subcritical growth of surface cracks was investigated. Comparison of chamber and open air welds showed chamber welds to be slightly tougher. Both methods produced welds with toughness that compared favorably with that of the parent metal. Weld efficiencies were above 94 percent.

  18. Expressing the sense of the House of Representatives regarding the life and work of Elie Wiesel in promoting human rights, peace, and Holocaust remembrance.

    THOMAS, 113th Congress

    Rep. Israel, Steve [D-NY-3

    2016-07-07

    09/12/2016 On motion to suspend the rules and agree to the resolution, as amended Agreed to by voice vote. (text: CR H5259) (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

  19. Management Information Reporting 2000-01 Data Analysis for Special Education, English as a Second Language (ESL), Early Literacy Initiative (ELI), and Technology Integration Funding (TIF).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton.

    This report is intended to stimulate inquiry into the achievement of special groups of students in Alberta schools and model reporting to the public on these students, a traditionally weak area of school board Annual Education Results reports. The data in the report provide provincial level comparisons to data that may be compiled by school…

  20. FONO: A difficult case for theory. The ELF and ELI-D topological studies on the chemical bonding using correlated wavefunctions

    NASA Astrophysics Data System (ADS)

    Berski, Slawomir; Gordon, Agnieszka J.; Latajka, Zdzislaw

    2013-04-01

    The complicated nature of the chemical bonding in cis and trans isomers of F-O-N=O is discussed based on the results obtained from the topological analysis of electron localization function (η) (ELF), electron localizability index (Y_D^σ), and electron density (ρ). The calculations have been performed for correlated wavefunctions using the CCSD and CASSCF methods. The F-O1 bond with non-bonding basins, V(F) and V'(O1), belongs to the protocovalent type (η,Y_D^σ) and its total population ranges between 0.2 and 0.4e. The central N-O1 bond in the cis form is protocovalent (η, Y_D^σ) with two basins, V(N) and V(O1). The total population oscillates between 0.7 and 0.9e. In the trans isomer, topology of ELF depends on used method. At the CCSD level only one non-bonding basin, V(N), is observed (η). Its population is about 0.5e. According to the definition of a heteronuclear charge-shift (CS) bond, only N-O1 bond in trans-FONO belongs to the CS class. A relation between η- and ρ-topology and N-O1 bond length is discussed.

  1. Oxygen transfer from an intramolecularly coordinated diaryltellurium oxide to acetonitrile. Formation and combined AIM and ELI-D analysis of a novel diaryltellurium acetimidate.

    PubMed

    Mallow, Ole; Bolsinger, Jens; Finke, Pamela; Hesse, Malte; Chen, Yu-Sheng; Duthie, Andrew; Grabowsky, Simon; Luger, Peter; Mebs, Stefan; Beckmann, Jens

    2014-08-01

    The reaction of the intramolecularly coordinated diaryltellurium(IV) oxide (8-Me2NC10H6)2TeO with acetonitrile proceeds with oxygen transfer and gives rise to the formation of the novel zwitterionic diaryltelluronium(IV) acetimidate (8-Me2NC10H6)2TeNC(O)CH3 (1) in 57% yield. Hydrolysis of 1 with hydrochloric acid affords acetamide and the previously known diarylhydroxytelluronium(IV) chloride [(8-Me2NC10H6)2Te(OH)]Cl. PMID:25026100

  2. "I Leave It with the People of the United States to Say": Autobiographical Disruption in the Personal Narratives of Black Hawk and Ely S. Parker

    ERIC Educational Resources Information Center

    Raheja, Michelle H.

    2006-01-01

    This essay demonstrates how American Indian autobiographical narratives work to construct a sense of American Indian subjectivity for competing communities--indigenous and white--by simultaneously promoting and protecting tribal knowledge. Both Black Hawk and Parker understood the power of print circulation in the dominant culture. One of the…

  3. Effects of the microstructure and porosity on properties of Ti-6Al-4V ELI alloy fabricated by electron beam melting (EBM)

    DOE PAGESBeta

    Galarraga, Haize; Lados, Diana A.; Dehoff, Ryan R.; Kirka, Michael M.; Nandwana, Peeyush

    2016-01-01

    Electron Beam Melting (EBM) is a metal powder bed-based Additive Manufacturing (AM) technology that makes possible the fabrication of three dimensional near-net-shaped parts directly from computer models. EBM technology has been in continuously updating, obtaining optimized properties of the processed alloys. Ti-6Al-4V titanium alloy is the most widely used and studied alloy for this technology and is the focus of this work. Several research works have been completed to study the mechanisms of microstructure formation as well as its influence on mechanical properties. However, the relationship is not completely understood, and more systematic research work is necessary in order tomore » attain a better understanding of these features. In this work, samples fabricated at different locations, orientations, and distances from the build platform have been characterized, studying the relationship of these variables with the resulting material intrinsic characteristics and properties (surface topography, microstructure, porosity, micro-hardness and static mechanical properties). This study has revealed that porosity is the main factor controlling mechanical properties relative to the other studied variables. Therefore, in future process developments, decreasing of the porosity should be considered as the primary goal in order to improve mechanical properties.« less

  4. Effects of the microstructure and porosity on properties of Ti-6Al-4V ELI alloy fabricated by electron beam melting (EBM)

    SciTech Connect

    Galarraga, Haize; Lados, Diana A.; Dehoff, Ryan R.; Kirka, Michael M.; Nandwana, Peeyush

    2016-01-01

    Electron Beam Melting (EBM) is a metal powder bed-based Additive Manufacturing (AM) technology that makes possible the fabrication of three dimensional near-net-shaped parts directly from computer models. EBM technology has been in continuously updating, obtaining optimized properties of the processed alloys. Ti-6Al-4V titanium alloy is the most widely used and studied alloy for this technology and is the focus of this work. Several research works have been completed to study the mechanisms of microstructure formation as well as its influence on mechanical properties. However, the relationship is not completely understood, and more systematic research work is necessary in order to attain a better understanding of these features. In this work, samples fabricated at different locations, orientations, and distances from the build platform have been characterized, studying the relationship of these variables with the resulting material intrinsic characteristics and properties (surface topography, microstructure, porosity, micro-hardness and static mechanical properties). This study has revealed that porosity is the main factor controlling mechanical properties relative to the other studied variables. Therefore, in future process developments, decreasing of the porosity should be considered as the primary goal in order to improve mechanical properties.

  5. 47. DETAIL OF ORIGINAL VANE ASSEMBLY AND TWO WHEEL SECTIONS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    47. DETAIL OF ORIGINAL VANE ASSEMBLY AND TWO WHEEL SECTIONS FROM ELI WINDMILLS, THE VANE SHEET BEARING STENCILED PAINTED INSCRIPTION, 'KREGEL WINDMILL CO. ELI NEBRASKA CITY, NEB.' VISIBLE IN THE IMAGE ARE BOTH SIDES OF THE WHEEL SECTIONS, SHOWING THE METHOD OF BLADE MOUNTING FOR ELI WINDMILLS. - Kregel Windmill Company Factory, 1416 Central Avenue, Nebraska City, Otoe County, NE

  6. SITE PROGRAM DEMONSTRATION ECO LOGIC INTERNATIONAL GAS-PHASE CHEMICAL REDUCTION PROCESS, BAY CITY, MICHIGAN TECHNOLOGY EVALUATION REPORT

    EPA Science Inventory

    The SITE Program funded a field demonstration to evaluate the Eco Logic Gas-Phase Chemical Reduction Process developed by ELI Eco Logic International Inc. (ELI), Ontario, Canada. The Demonstration took place at the Middleground Landfill in Bay City, Michigan using landfill wa...

  7. Syracuse University English Language Institute: Business Communication for Executives

    ERIC Educational Resources Information Center

    de Berly, Geraldine; McGraw, Deborah

    2010-01-01

    The Syracuse University English Language Institute (ELI), housed within University College, has been offering noncredit executive English courses on a contract basis for the past 12 years. Despite its small size and limited resources, the ELI, whose main mission is to prepare international students for academic study, also manages a successful…

  8. Knowledge-based reusable software synthesis system

    NASA Technical Reports Server (NTRS)

    Donaldson, Cammie

    1989-01-01

    The Eli system, a knowledge-based reusable software synthesis system, is being developed for NASA Langley under a Phase 2 SBIR contract. Named after Eli Whitney, the inventor of interchangeable parts, Eli assists engineers of large-scale software systems in reusing components while they are composing their software specifications or designs. Eli will identify reuse potential, search for components, select component variants, and synthesize components into the developer's specifications. The Eli project began as a Phase 1 SBIR to define a reusable software synthesis methodology that integrates reusabilityinto the top-down development process and to develop an approach for an expert system to promote and accomplish reuse. The objectives of the Eli Phase 2 work are to integrate advanced technologies to automate the development of reusable components within the context of large system developments, to integrate with user development methodologies without significant changes in method or learning of special languages, and to make reuse the easiest operation to perform. Eli will try to address a number of reuse problems including developing software with reusable components, managing reusable components, identifying reusable components, and transitioning reuse technology. Eli is both a library facility for classifying, storing, and retrieving reusable components and a design environment that emphasizes, encourages, and supports reuse.

  9. Extended Learning Institute. Policies and Procedures Manual.

    ERIC Educational Resources Information Center

    Adams, Larry

    This manual describes the Extended Learning Institute (ELI) at John Tyler Community College in Virginia. The ELI is a comprehensive program of instruction using alternative delivery systems (e.g., television, print-based, radio, and newspapers). General procedures and policies are delineated in section I, including registration and student and…

  10. On failures in education and public policy

    NASA Astrophysics Data System (ADS)

    Ely, John T. A.

    2007-04-01

    Education of the public and the resulting policies in many matters are grossly inadequate. Included as a small list of four samples of failings in vital matters are: 1. Societal Cohesiveness: A profound change in the school system will yield great benefit for the nation (http://faculty.washington.edu/ely/publicservice.html.). 2. Lack of understanding regarding the coming avian flu pandemic (http://faculty.washington.edu/ely/ElyFluMES.pdf). 3. Severe Hg intoxication from dentistry due to profound multifaceted ignorance (Ely JTA, Mercury induced Alzheimer's disease: accelerating incidence? Bull Environ Contam Toxicol. 2001; 67(6),800-6). 4. The end of the world by global warming due to Christian religion forcing family planning money to be withheld from UN leading to population excess (http://faculty.washington.edu/ely/CO2runaway.html).

  11. 19. The 1860 armory building, c.1930 Photocopied from a film ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. The 1860 armory building, c.1930 Photocopied from a film negative, NHCHSL. A view from the southwest. - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  12. 20. Mill River and rear of the 1860 armory building, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. Mill River and rear of the 1860 armory building, c. 1930. Photocopied from a print of a film negative, NHCHSL. View from the south. - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  13. BIOMONITORING: INTERPRETATION AND USES

    EPA Science Inventory

    With advanced technologies, it is now possible to measure very low levels of many chemicals in biological fluids. However, the appropriate use and interpretation of biomarkers will depend upon many factors associated with the exposure, adsorption, deposition, metabolism, and eli...

  14. What Is Geometry?

    ERIC Educational Resources Information Center

    Chern, Shiing-Shen

    1990-01-01

    Discussed are the major historical developments of geometry. Euclid, Descartes, Klein's Erlanger Program, Gaus and Riemann, globalization, topology, Elie Cartan, and an application to molecular biology are included as topics. (KR)

  15. Microbial Protein-Antigenome Determination (MAD) Technology: A Proteomics-Based Strategy for Rapid Identification of Microbial Targets of Host Humoral Immune Responses

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Immunogenic, pathogen-specific proteins have excellent potential for development of novel management modalities. Here, we describe an innovative application of proteomics called Microbial protein-Antigenome Determination (MAD) Technology for rapid identification of native microbial proteins that eli...

  16. Deep Space Atomic Clock Ticks Toward Success

    NASA Video Gallery

    Dr. Todd Ely, principal investigator for NASA's Deep Space Atomic Clock at the Jet Propulsion Laboratory in Pasadena, Calif., spotlights the paradigm-busting innovations now in development to revol...

  17. 13. Historic American Buildings Survey (Fed.) Stanley P. Mixon, Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. Historic American Buildings Survey (Fed.) Stanley P. Mixon, Photographer May 16, 1940 (K) INT. DETAIL OF PART OF FEATHER EDGE PANELING AND DOOR (NORTHEAST ROOM, FIRST FLOOR) - Eli Adams House, Oakham, Worcester County, MA

  18. IMMUNOCHEMICAL DETERMINATION OF DIOXINS IN SEDIMENT SAMPLES

    EPA Science Inventory

    Polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) are considered highly toxic contaminants with the environmental monitoring of these compounds being of great importance. Immunoassay procedures such as the enzyme-linked immunosorbent assay (ELIS...

  19. 23. Site plan, 1931 Photocopied from Sanborn Map Company, Insurance ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. Site plan, 1931 Photocopied from Sanborn Map Company, Insurance Maps of New Haven, v. 5, map no. 540, 1924 updated to 1931. - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  20. 21. General view from the southwest, c.1862 Photocopied from an ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. General view from the southwest, c.1862 Photocopied from an advertisement, 'Whitney's Improved Fire-Arms,' Dana Scrapbook v. 61, p. 68, NHCHSL. - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  1. 24. Site plan, 1924 Photocopied from Sanborn Map Company, Insurance ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    24. Site plan, 1924 Photocopied from Sanborn Map Company, Insurance Maps of New Haven, v. 5, map no. 540, 1924 - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  2. Following electron impact excitations of single Os, Pt, Hg, Pb and Po atom L subshells ionization cross section calculations by using Lotz's equation

    NASA Astrophysics Data System (ADS)

    Aydinol, M.; Aydeniz, D.

    2016-03-01

    L shell ionization cross section and Li subshells ionization cross sections of Os, Pt, Hg, Pb, Po atoms calculated. For each atom, ten different electron impacty energy values Eoi used. Calculations carried out by using nonrelativistic Lotz equation in Matlab. Ionization cross section values obtained for Eoi values in the energy range of ELi ≤Eoi≤4ELi for each atom. Starting allmost from Eoi = ELi (i = 1,2,3) values of the each subshell ionization threshold energy, ionization cross section are increasing rapidly with Eoi. For a fixed Eoi = 3. ELi values, while Z increases from Z = 76 to Z = 84, ionization cross section are decrease. These results help to understand some results which obtained from other electron-sigle atom impact studies on σLi subshells.

  3. 76 FR 65509 - Environmental Impact Statements; Notice of Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-21

    ...-0077 Revision to FR Notice Published 07/29/2011: Extending Comment Period from 10/27/2011 to 12/02/2011... . EIS No. 20110349, Final EIS, USFS, NV, Ely Westside Rangeland Project, Authorization of...

  4. 75 FR 11549 - Determination That PRO-BANTHINE (Propantheline Bromide) Tablets and 14 Other Drug Products Were...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-11

    ..., 2009 (74 FR 6896).) Application No. Drug Applicant NDA 8-732 PRO-BANTHINE Shire Pharmaceuticals... NDA 20-101 PROZAC (fluoxetine HCl) Eli Lilly and Co., Oral Solution, EQ 20 Lilly Corporate mg base/5...

  5. Photonuclear reactions: Past, present, and future

    SciTech Connect

    Pietralla, N.

    2012-07-09

    This contribution is supposed to provide an introduction to the discussion of future research opportunities at the planned {gamma}-ray beam of the ELI-Nuclear Physics pillar. It contains a brief overview on the history of photonuclear science, some fundamental facts on photonuclear reactions at energies below 20 MeV, a few examples for recent photonuclear research, and a brief outlook to a future with ELI-NP.

  6. High intensity X/γ photon beams for nuclear physics and photonics

    NASA Astrophysics Data System (ADS)

    Serafini, L.; Alesini, D.; Bacci, N.; Bliss, N.; Cassou, K.; Curatolo, C.; Drebot, I.; Dupraz, K.; Giribono, A.; Petrillo, V.; Palumbo, L.; Vaccarezza, C.; Variola, A.; Zomer, F.

    2016-05-01

    In this manuscript we review the challenges of Compton backscattering sources in advancing photon beam performances in the 1 - 20 MeV energy range, underlining the design criteria bringing to maximum spectral luminosity and briefly describing the main achievements in conceiving and developing new devices (multi-bunch RF cavities and Laser recirculators) for the case of ELI-NP Gamma Beam System (ELI-NP-GBS).

  7. Cambrian rocks of the Pioche mining district, Nevada, with a section on Pioche shale faunules

    USGS Publications Warehouse

    Merriam, Charles Warren; Palmer, Allison R.

    1964-01-01

    The Pioche mining district in the Ely Range, southeastern Nevada, is one of several districts in the Great Basin where Cambrian rocks are hosts of important ore deposits. Cambrian strata underlying the Ely Range are intruded by porphyritic granite and other dikes. Tertiary volcanic rocks and Pliocene fresh-water clastic deposits of the Panaca Formation occupy adjacent valleys and extend over the Cambrian strata on the south and east.

  8. Development of an Anti-Elicitin Antibody-Based Immunohistochemical Assay for Diagnosis of Pythiosis.

    PubMed

    Inkomlue, Ruchuros; Larbcharoensub, Noppadol; Karnsombut, Patcharee; Lerksuthirat, Tassanee; Aroonroch, Rangsima; Lohnoo, Tassanee; Yingyong, Wanta; Santanirand, Pitak; Sansopha, Lalana; Krajaejun, Theerapong

    2016-01-01

    Pythiosis is an emerging and life-threatening infectious disease of humans and animals living in tropical and subtropical countries and is caused by the fungus-like organism Pythium insidiosum. Antifungals are ineffective against this pathogen. Most patients undergo surgical removal of the infected organ, and many die from advanced infections. Early and accurate diagnosis leads to prompt management and promotes better prognosis for affected patients. Immunohistochemical assays (IHCs) have been developed using rabbit antibodies raised against P. insidiosum crude extract, i.e., culture filtrate antigen (CFA), for the histodiagnosis of pythiosis, but cross-reactivity with pathogenic fungi compromises the diagnostic performance of the IHC. Therefore, there is a need to improve detection specificity. Recently, the elicitin protein, ELI025, was identified in P. insidiosum, but it was not identified in other human pathogens, including true fungi. The ELI025-encoding gene was successfully cloned and expressed as a recombinant protein in Escherichia coli. This study aims to develop a new IHC using the rabbit anti-ELI025 antibody (anti-ELI) and to compare its performance with the previously reported anti-CFA-based IHC. Thirty-eight P. insidiosum histological sections stained positive by anti-ELI-based and anti-CFA-based IHCs indicating 100% detection sensitivity for the two assays. The anti-ELI antibody stained negative for all 49 negative-control sections indicating 100% detection specificity. In contrast, the anti-CFA antibody stained positive for one of the 49 negative controls (a slide prepared from Fusarium-infected tissue) indicating 98% detection specificity. In conclusion, the anti-ELI based IHC is sensitive and specific for the histodiagnosis of pythiosis and is an improvement over the anti-CFA-based assay. PMID:26719582

  9. Development of an Anti-Elicitin Antibody-Based Immunohistochemical Assay for Diagnosis of Pythiosis

    PubMed Central

    Inkomlue, Ruchuros; Larbcharoensub, Noppadol; Karnsombut, Patcharee; Lerksuthirat, Tassanee; Aroonroch, Rangsima; Lohnoo, Tassanee; Yingyong, Wanta; Santanirand, Pitak; Sansopha, Lalana

    2015-01-01

    Pythiosis is an emerging and life-threatening infectious disease of humans and animals living in tropical and subtropical countries and is caused by the fungus-like organism Pythium insidiosum. Antifungals are ineffective against this pathogen. Most patients undergo surgical removal of the infected organ, and many die from advanced infections. Early and accurate diagnosis leads to prompt management and promotes better prognosis for affected patients. Immunohistochemical assays (IHCs) have been developed using rabbit antibodies raised against P. insidiosum crude extract, i.e., culture filtrate antigen (CFA), for the histodiagnosis of pythiosis, but cross-reactivity with pathogenic fungi compromises the diagnostic performance of the IHC. Therefore, there is a need to improve detection specificity. Recently, the elicitin protein, ELI025, was identified in P. insidiosum, but it was not identified in other human pathogens, including true fungi. The ELI025-encoding gene was successfully cloned and expressed as a recombinant protein in Escherichia coli. This study aims to develop a new IHC using the rabbit anti-ELI025 antibody (anti-ELI) and to compare its performance with the previously reported anti-CFA-based IHC. Thirty-eight P. insidiosum histological sections stained positive by anti-ELI-based and anti-CFA-based IHCs indicating 100% detection sensitivity for the two assays. The anti-ELI antibody stained negative for all 49 negative-control sections indicating 100% detection specificity. In contrast, the anti-CFA antibody stained positive for one of the 49 negative controls (a slide prepared from Fusarium-infected tissue) indicating 98% detection specificity. In conclusion, the anti-ELI based IHC is sensitive and specific for the histodiagnosis of pythiosis and is an improvement over the anti-CFA-based assay. PMID:26719582

  10. Rb-Sr ages of the Archean rocks from the Vermilion district, northeastern Minnesota

    NASA Technical Reports Server (NTRS)

    Jahn, B.-M.; Murthy, V. R.

    1975-01-01

    The Vermilion district in Northeastern Minnesota is a classic example of a lower Precambrian greenstone-granite terrane in the Superior Province of the Canadian Shield. The present study presents new Rb-Sr isotopic data for the Ely Greenstone, the Newton Lake Formation, granitic pebbles that occur within the Ely Greenstone, a graywacke composite of the Knife Lake Group, and some Algoman granites whose data are complementary to those of Peterman et al. (1972). The isochron ages obtained are statistically indistinguishable and therefore cannot be used to resolve the timing of specific geologic events. Volcanic extrusion, granitic intrusion, and metamorphism are shown to be less contemporaneous events which probably took place within a time span of less than 50 m.y. A major conclusion is that a granitic basement probably did not underlie the Ely Greenstone.

  11. Electronic state-lifetime interference in resonant Auger spectra: a tool to disentangle overlapping core-excited states.

    PubMed

    Goldsztejn, Gildas; Marchenko, Tatiana; Céolin, Denis; Journel, Loïc; Guillemin, Renaud; Rueff, Jean-Pascal; Kushawaha, Rajesh K; Püttner, Ralph; Piancastelli, Maria Novella; Simon, Marc

    2016-06-01

    We have measured resonant-Auger decay following Cl 1s(-1) excitations in HCl and CH3Cl molecules, and extracted the pseudo-cross sections of different Cl 2p(-2) final states. These cross sections show clear evidence of shake processes as well as contributions of electronic state-lifetime interference (ELI). To describe the spectra we developed a fit approach that takes into account ELI contributions and ultrafast nuclear dynamics in dissociative core-excited states. Using this approach we utilized the ELI contributions to obtain the intensity ratios of the overlapping states Cl 1s(-1)4pπ/1s(-1)4pσ in HCl and Cl 1s(-1)4pe/1s(-1)4pa1 in CH3Cl. The experimental value for HCl is compared with theoretical results showing satisfactory agreement. PMID:27199185

  12. Estimates for production of radioisotopes of medical interest at Extreme Light Infrastructure - Nuclear Physics facility

    NASA Astrophysics Data System (ADS)

    Luo, Wen; Bobeica, Mariana; Gheorghe, Ioana; Filipescu, Dan M.; Niculae, Dana; Balabanski, Dimiter L.

    2016-01-01

    We report Monte Carlo simulations of the production of radioisotopes of medical interest through photoneutron reactions using the high-brilliance γ-beam of the Extreme Light Infrastructure - Nuclear Physics (ELI-NP) facility. The specific activity for three benchmark radioisotopes, 99Mo/99Tc, 225Ra/225Ac and 186Re, was obtained as a function of target geometry, irradiation time and γ-beam energy. Optimized conditions for the generation of these radioisotopes of medical interest with the ELI-NP γ-beams were discussed. We estimated that a saturation specific activity of the order of 1-2 mCi/g can be achieved for thin targets with about one gram of mass considering a γ-beam flux of 10^{11} photons/s. Based on these results, we suggest that the ELI-NP facility can provide a unique possibility for the production of radioisotopes in sufficient quantities for nuclear medicine research.

  13. 31. WEST TO PARTS AND TOOLS LOCATED DIRECTLY OPPOSITE FROM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    31. WEST TO PARTS AND TOOLS LOCATED DIRECTLY OPPOSITE FROM THE BLACKSMITH SHOP AREA IN THE NORTHEAST QUADRANT OF THE FACTORY. ON THE FLOOR AT THE LEFT SIDE IS A MANUAL PIPE THREADER FOR LARGE-DIAMETER PIPE (AS DROP PIPE IN WELLS FOR WATER SYSTEMS). BENEATH THE BENCH ARE UNMACHINED NEW OLD STOCK MAIN CASTINGS FOR ELI WINDMILLS, TOGETHER WITH A USED MAIN SHAFT/WHEEL HUB/CRANK PLATE ASSEMBLY WITH 1920S-1930S OIL RESERVOIR FROM ELI WINDMILL. THE CIRCULAR CASTING WITH CRESCENT-SHAPED PATTERNS IS A PORTION OF THE CAM MECHANISM FROM A 'WESTERN GEARED GEARLESS' WINDMILL MADE BY THE WESTERN LAND ROLLER CO., HASTINGS, NEB. TO THE RIGHT ON THE BENCH IS A GEARED TIRE BENDER USED TO GIVE CURVATURE TO WHEEL RIMS OF ELI WINDMILLS. IN THE BACKGROUND ARE ... - Kregel Windmill Company Factory, 1416 Central Avenue, Nebraska City, Otoe County, NE

  14. Watershed Restoration Project

    SciTech Connect

    Julie Thompson; Betsy Macfarlan

    2007-09-27

    In 2003, the U.S. Department of Energy issued the Eastern Nevada Landscape Coalition (ENLC) funding to implement ecological restoration in Gleason Creek and Smith Valley Watersheds. This project was made possible by congressionally directed funding that was provided through the US Department of Energy, Energy Efficiency and Renewable Energy, Office of the Biomass Program. The Ely District Bureau of Land Management (Ely BLM) manages these watersheds and considers them priority areas within the Ely BLM district. These three entities collaborated to address the issues and concerns of Gleason Creek and Smith Valley and prepared a restoration plan to improve the watersheds’ ecological health and resiliency. The restoration process began with watershed-scale vegetation assessments and state and transition models to focus on restoration sites. Design and implementation of restoration treatments ensued and were completed in January 2007. This report describes the restoration process ENLC undertook from planning to implementation of two watersheds in semi-arid Eastern Nevada.

  15. Introduction to Electrochemical Process Integration for Cu Interconnects

    NASA Astrophysics Data System (ADS)

    Ohba, Takayuki

    This chapter focuses on advanced multilevel interconnects, contributed by distinguished authors in the following sections: Damascene Concept and Process Steps (Nobuyoshi Kobayashi), Advanced BEOL Technology Overview (Takashi Yoda and Hideshi Miyajima), Lithography for Cu Damascene fabrication (Yoshihiro Hayashi), Physical Vapor Deposition Barriers for Cu metallization PVD Barriers (Junichi Koike), Low-k dielectrics (Yoshihiro Hayashi), CMP for Cu Processing (Manabu Tsujimura), Electrochemical View of Copper Chemical Mechanical Polishing (CMP) (D. Starosvetsky and Y. Ein-Eli), and Copper Post-CMP Cleaning (D. Starosvetsky and Y. Ein-Eli).

  16. TESL Reporter, Vol. 6, No. 3.

    ERIC Educational Resources Information Center

    Pack, Alice C., Ed.

    The following articles on teaching English as a second language are included in this issue: (1) "ELI Tutorial" (about the tutorial program at the English Language Institute of the Church College of Hawaii) by Michael E. Foley; (2) "English-TESL Programs at the Church College of Hawaii" by Jay Fox; (3) "Developmental Speech Classes" by Brent…

  17. The NMC Horizon Report: 2015 Higher Education Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Adams Becker, S.; Estrada, V.; Freeman, A.

    2015-01-01

    The "NMC Horizon Report: 2015 Higher Education Edition" is a collaborative effort between the New Media Consortium (NMC) and the EDUCAUSE Learning Initiative (ELI). This 12th edition describes annual findings from the NMC Horizon Project, an ongoing research project designed to identify and describe emerging technologies likely to have…

  18. Applying Diversity Management Concepts to Improve the Minority Educational Pipeline

    ERIC Educational Resources Information Center

    Oguntebi, Joy; Shcherbakova, Maria; Wooten, Lynn P.

    2012-01-01

    The objective of this conceptual article is to investigate existing diversity management paradigms and extend their implications toward the goal of increasing minority representation in management education. We suggest that the existing learning-and-effectiveness diversity management paradigm (Thomas & Ely, 1996, "Harvard Business…

  19. Literature of the Holocaust: The Imagination after Auschwitz. A Course for Juniors and Seniors. A Teacher's Guide.

    ERIC Educational Resources Information Center

    Klau, Judith R.

    This guide presents a curriculum on the literature of the Holocaust which focuses on the ways in which a particular period in history affected the literature that was created to tell about it. The guide consists of a detailed set of lesson plans for six literary works: a diverse collection of short stories; Elie Wiesel's autobiographical novel,…

  20. Contemporary Approaches to Conditioning and Learning.

    ERIC Educational Resources Information Center

    McGuigan, F. J., Ed.; Lumsden, D. Barry, Ed.

    Chapters contained in this volume, each with a list of references appended, are: "Scientific Psychology in Transition" by Gregory A. Kimble; "Higher Mental Processes as the Bases for the Laws of Conditioning" by Eli Saltz; "Reification and Reality in Conditioning Paradigms: Implications of Results When Modes of Reinforcement are Changed" by David…

  1. Found in Translations: Using Multiple Versions of Translated Text for Close Analysis of Language

    ERIC Educational Resources Information Center

    Larochelle, Paul

    2011-01-01

    To prepare students for the rigorous tasks of the unseen written commentary and the oral commentary on an extract from a studied text, the author has had to explore new ways of engaging students in attending to the subtleties of language. Inspired by a classroom mishap regarding translations of Elie Wiesel's "Night," the author uses multiple text…

  2. Following electron impact excitations of Rn, Ra, Th, U and Pu single atom L sub-shells ionization cross section calculations by using Lotz's equation

    NASA Astrophysics Data System (ADS)

    Ayinol, M.; Aydeniz, D.

    2016-03-01

    L shell ionization cross section and Li subshells ionization cross sections of Rn, Ra, Th, U, Pu atoms calculated. For each of atoms, ten different electron impact energy values (Eo) are used. Calculations carried out by using Lotz equation in Matlab. First, calculations done for non-relativistic case by using non-relativistic Lotz equation then repeated with relativistic Lotz equation. σL total and σLi(i = 1,2,3) subshells ionisation cross section values obtained for Eo values in the energy range of ELi ELi for each atom. Starting almost from Eo = ELi values of the each sub shell ionization threshold energy, σL total and σLi (i = 1,2,3) are increasing rapidly with Eo. For a fixed Eo = 3.ELi), while Z increases from 86

  3. 76 FR 76894 - New Animal Drugs for Use in Animal Feeds; Tilmicosin

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-09

    ...The Food and Drug Administration (FDA) is amending the animal drug regulations to reflect approval of a supplemental new animal drug application (NADA) filed by Elanco Animal Health, a division of Eli Lilly & Co. The supplemental NADA provides for use of tilmicosin Type C medicated feeds by veterinary feed directive for the control of bovine respiratory disease in groups of beef and......

  4. Innovations in Corporate Career Centers--Special Issue.

    ERIC Educational Resources Information Center

    Patch, Ken, Ed.

    2000-01-01

    Nine articles describe corporate career centers at Advanced Macro Devices, Sun Microsystems, Tellabs, DaimlerChrysler, Eli Lilly, Toronto Dominion Bank, Motorola, Honeywell, and Dow Corning. Other articles give an historical overview and address virtual career centers, talent management, and future directions. (SK)

  5. The Seeds to Success Modified Field Test: Findings from the Impact and Implementation Studies

    ERIC Educational Resources Information Center

    Boller, Kimberly; Del Grosso, Patricia; Blair, Randall; Jolly, Yumiko; Fortson, Ken; Paulsell, Diane; Lundquist, Eric; Hallgren, Kristin; Kovac, Martha

    2010-01-01

    In 2006, the Bill & Melinda Gates Foundation launched the Early Learning Initiative (ELI) to improve the school readiness of Washington State's children through three main strategies: (1) development of high-quality, community-wide early learning initiatives in two communities; (2) enhancement of statewide systems that support early learning;…

  6. SITE TECHNOLOGY CAPSULE; MULTI-VENDOR BIOREMEDIATION DEMONSTRATION PROJECT: ENVIRONMENTAL LABORATORIES/SBP TECHNOLOGIES' UVB VACUUM VAPORIZATION WELL PROCESS

    EPA Science Inventory

    This technology capsule summarizes the findings of an evaluation of the Unterdruck-Verdampfer-Brunnen (UVB) technology developed by IEG Technologies (IEG) and licensed in the eastern United States by Environmental Laboratories, Inc. (ELI) and SBP Technologies, Inc. (SBP). This e...

  7. Chemical and Hot Water Treatments to Eliminate Rhizoctonia From Azalea Stem Cuttings: Failures and Successes

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Azalea web blight is an annual problem on some evergreen azalea cultivars grown in containerized nursery production in the southern and eastern United States. The binucleate Rhizoctonia species, which cause the disease, are spread on new shoot growth harvested for propagation. Rhizoctonia can be eli...

  8. Special cancer microenvironment in human colonic cancer: Concept of cancer microenvironment formed by peritoneal invasion (CMPI) and implication of subperitoneal fibroblast in cancer progression

    PubMed Central

    Ochiai, Atsushi

    2016-01-01

    Clinical outcomes of colorectal cancer are influenced not by tumor size, but by spread into the bowel wall. Although assessment of serosal involvement is an important pathological feature for classification of colon cancer, its diagnostic consistency has been questioned. Using elastic staining, we assessed elastic laminal invasion (ELI) for more objective stratification of deep tumor invasion around the peritoneal surface. In addition, pathological characteristic features of marked tumor budding, fibrosis, and macrophage infiltration in the tumor area with ELI was elucidated. This characteristic tumor area was termed cancer microenvironment formed by peritoneal elastic laminal invasion (CMPI). We elucidated histoanatomical layer‐dependent heterogeneity of fibroblast in colonic tissue. Furthermore, subperitoneal fibroblasts (SPFs) play a crucial role in tumor progression and metastasis in CMPI. Our ELI and CMPI concept contributes not only to objective pathological diagnosis, but also sheds light on biological research of special cancer microenvironments detectable in human colorectal cancers. Herein, we describe the diagnostic utility of ELI and morphological alteration in advanced colorectal cancers to determine the phenomenon that occurs when tumors invade around the peritoneal surface. Next, biological research of CMPI is reviewed to stress the importance of pathological research to establish new biological concepts. PMID:26816328

  9. 77 FR 4228 - New Animal Drugs for Use in Animal Feeds; Monensin

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-27

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 558 New Animal Drugs for Use in Animal Feeds... Administration (FDA) is amending the animal drug regulations to reflect approval of a supplemental new animal drug application (NADA) filed by Elanco Animal Health, A Division of Eli Lilly & Co. The...

  10. Better Leaders for America's Schools: A Manifesto. With Profiles of Education Leaders and a Summary of State Certification Practices.

    ERIC Educational Resources Information Center

    Meyer, Lawrence; Feistritzer, Emily

    This volume was created around the premise that America's schools face a crisis in leadership. For America to have the great schools it needs, schools and their school systems must have great leaders. After a foreword by Chester E. Finn, Jr. and an introduction by Eli Broad, the book is divided into three parts. The first part presents a manifesto…

  11. God on the Gallows: Reading the Holocaust through Narratives of Redemption

    ERIC Educational Resources Information Center

    Spector, Karen

    2007-01-01

    "Where is God now?" is a question from the Holocaust memoir "Night" by Elie Wiesel and an underlying narrative dilemma for the teachers and most student participants in this qualitative study of three Holocaust units in secondary English classrooms in the Midwestern United States. Using a narrative theory framework, this study explores how…

  12. In vitro activity of ponazuril against Theileria equi

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The equid hemoprotozoan parasite Theileria equi is endemic in most regions worldwide. Infection of horses is a cause of significant economic loss due to costs associated with disease and restriction of trade with non-endemic nations. The ability of certain drugs such as imidocarb dipropionate to eli...

  13. Investigating the News Seeking Behavior of Young Adults

    ERIC Educational Resources Information Center

    Qayyum, M. Asim; Williamson, Kirsty; Liu, Ying-Hsang; Hider, Philip

    2010-01-01

    This study investigated the news-seeking and browsing behaviours of young adults, partly in the context of everyday life information seeking (ELIS), in order to explore their perceptions of and attitudes towards print and online news media. The study is significant because traditional print newspapers face a steady decline in their readership with…

  14. 77 FR 22608 - Notice of Intent To Prepare an Environmental Impact Statement for the Proposed Bald Mountain Mine...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-16

    ...In compliance with the National Environmental Policy Act of 1969, as amended, (NEPA) and the Federal Land Policy and Management Act (FLPMA) of 1976, as amended, the Bureau of Land Management (BLM) Egan Field Office, Ely, Nevada intends to prepare an Environmental Impact Statement (EIS) and by this notice is announcing the beginning of the scoping process to solicit public comments and identify......

  15. The Learning Age: Experts Give Their Views on the Government's Green Paper.

    ERIC Educational Resources Information Center

    Adults Learning (England), 1998

    1998-01-01

    Includes reactions to "The Learning Age" from the following: A.G. Watts, Richard Taylor, Richard Ely, Carole Stott, Donald Rae, John Lawton, Philippa Langton, Mary Lord, and Sarah Perman. Emphasizes the need for practitioner input from their varied experiences and for knowledge of client groups into the continuing development of the educational…

  16. K-12 Computer Networking.

    ERIC Educational Resources Information Center

    ERIC Review, 1993

    1993-01-01

    The "ERIC Review" is published three times a year and announces research results, publications, and new programs relevant to each issue's theme topic. This issue explores computer networking in elementary and secondary schools via two principal articles: "Plugging into the 'Net'" (Michael B. Eisenberg and Donald P. Ely); and "Computer Networks for…

  17. Pathway-based Analysis of Fish Transcriptomics Data across Effluent Gradients in Minnesota Rivers

    EPA Science Inventory

    As part of a larger effort to assess the health of streams and rivers in Minnesota, a series of caged fish experiments were conducted in three locations: Ely, Hutchinson, and Rochester. The experimental design placed caged fish (fathead minnows, Pimephales promelas; FHM) across ...

  18. Guiding School Change: The Role and Work of Change Agents. The Series on School Reform.

    ERIC Educational Resources Information Center

    Rust, Frances O'Connell, Ed.; Freidus, Helen, Ed.

    This book examines facilitators of change, as viewed by the change agents themselves. It highlights their role and how they can be prepared and supported. In chapter 1, Frances O'Connell Rust, Margot Ely, Maris H. Krasnow, and LaMar P. Miller report on the successful professional development of early elementary teachers in New York City. In…

  19. 40 CFR 80.215 - What is the scope of the geographic phase-in program?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... the geographic phase-in program: North Dakota, Montana, Idaho, Wyoming, Utah, Colorado, New Mexico... River Haakon Harding Jackson Jones Lawrence Meade Mellette Pennington Perkins Shannon Stanley Todd... Indian reservations follows: Burns Paiute, Cheyenne River, Colville, Duck Valley, Ely Colony, Fort...

  20. 40 CFR 80.215 - What is the scope of the geographic phase-in program?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the geographic phase-in program: North Dakota, Montana, Idaho, Wyoming, Utah, Colorado, New Mexico... River Haakon Harding Jackson Jones Lawrence Meade Mellette Pennington Perkins Shannon Stanley Todd... Indian reservations follows: Burns Paiute, Cheyenne River, Colville, Duck Valley, Ely Colony, Fort...

  1. 40 CFR 80.215 - What is the scope of the geographic phase-in program?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the geographic phase-in program: North Dakota, Montana, Idaho, Wyoming, Utah, Colorado, New Mexico... River Haakon Harding Jackson Jones Lawrence Meade Mellette Pennington Perkins Shannon Stanley Todd... Indian reservations follows: Burns Paiute, Cheyenne River, Colville, Duck Valley, Ely Colony, Fort...

  2. Trendspotting 2011

    ERIC Educational Resources Information Center

    Thomas, Lisa Carlucci

    2011-01-01

    In this article, the author discusses Connecticut Library Consortium's (CLC) recently held fifth annual Trendspotting symposium, "E-books: Collections at the Crossroads." She was pleased to work with CLC to develop a cutting-edge program of dynamic, thought-provoking speakers and presentations, including an outstanding keynote by Eli Neiburger on…

  3. Charters, Constitutions and By-Laws of the Indian Tribes of North America, Part XII: The Basin-Plateau Tribes (cont'd.). Occasional Publications in Anthropology, Ethnology Series, No. 13.

    ERIC Educational Resources Information Center

    Fay, George E., Comp.

    The Museum of Anthropology, University of Northern Colorado at Greeley, has assembled various American Indian tribal charters, constitutions, and by-laws to comprise a series of publications. The present volume, Part XII, is a continuation of the publication on Basin-Plateau Indian groups: the Ely Indian Colony and Reno-Sparks Indian Colony of…

  4. 18. View from East Rock, c. 1920 Photocopied from a ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. View from East Rock, c. 1920 Photocopied from a print from glass negative no. 6476 by Thomas S. Bronson, NHCHSL. An aerial view of the armory site evidently after the row of stone houses for married employees had been torn down. - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  5. ECO LOGIC INTERNATIONAL GAS-PHASE CHEMICAL REDUCTION PROCESS - THE THERMAL DESORPTION UNIT - APPLICATIONS ANALYSIS REPORT

    EPA Science Inventory

    ELI ECO Logic International, Inc.'s Thermal Desorption Unit (TDU) is specifically designed for use with Eco Logic's Gas Phase Chemical Reduction Process. The technology uses an externally heated bath of molten tin in a hydrogen atmosphere to desorb hazardous organic compounds fro...

  6. Phonological Awareness and Word Recognition in Reading by Children with Autism

    ERIC Educational Resources Information Center

    Gabig, Cheryl Smith

    2010-01-01

    This research examined phonological awareness (PA) and single word reading in 14 school-age children with autism and 10 age-matched, typically developing (TD) children between 5-7 years. Two measures of PA, an elision task (ELI) and a sound blending task (BLW), were given along with two measures of single word reading, word identification for real…

  7. Online Information Retrieval for Economists: The Economic Literature Index.

    ERIC Educational Resources Information Center

    Ekwurzel, Drucilla; Saffran, Bernard

    1985-01-01

    The basics of online searching for bibliographic citations are presented through use of the "Economic Literature Index" (ELI), which is available as File 139 on Dialog Information Services. This article focuses on the choice of media for bibliographic searches, search strategies, and the selection of alternative databases, such as "Social…

  8. 2,4,5-TRICHLOROPHENOXYACETIC ACID INFLUENCE ON 2,6-DINITROTOLUENE-INDUCED URINE GENOTOXICITY IN FISCHER 344 RATS: EFFECT ON G.I. MICROFLORA AND ENZYME ACTIVITY

    EPA Science Inventory

    2,4,5-Trichlorophenoxyacetic acid and 2,6-dinitrotoluene are hazardous chemicals that have potential harmful effects 2,6-DNT is recognized as a hepatoxicant while 2,4,5-T, a component in Agent Orange, is also suspect. ,6-DNT requires both oxidative and reductive metabolism to eli...

  9. Vocational Education and Training.

    ERIC Educational Resources Information Center

    van Leeuwen, Fred, Ed.

    2000-01-01

    This issue of the quarterly Education International focuses on vocational education and training (VET). The editorial, "Education and the Wealth of Nations" (Fred van Leeuwen), focuses on provision of quality education for all. "Education International's (EI's) First Joint Worldwide Action on Education Issues" (Elie Jouen) describes the Global…

  10. An Analysis of the Associations between Ambiguity Tolerance and EFL Reading Strategy Awareness

    ERIC Educational Resources Information Center

    Kamran, Saeedeh Karbalaee; Maftoon, Parviz

    2012-01-01

    The current study is an attempt to investigate whether any statistically significant relationship existed between Iranian EFL learners' ambiguity tolerance (AT) and their reading strategy use. To this end, three instruments of Survey of Reading Strategy (Mokhtari & Sheorey, 2002), Second Language Ambiguity Tolerance Scale (Ely, 1995), and a…

  11. Comparison of Ergot Alkaloid Biosynthesis Gene Clusters in Claviceps Species Indicates Loss of Late Pathway Steps in Evolution of C. fusiformis

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The grass parasites Claviceps purpurea and Claviceps fusiformis produce ergot alkaloids (EA) in planta and in submerged culture. Whereas EA synthesis (EAS) in C. purpurea proceeds via clavine intermediates to lysergic acid and the complex ergopeptines, C. fusiformis produces only agroclavine and ely...

  12. The Transformation of the Urban Economic Base. Special Report No. 19.

    ERIC Educational Resources Information Center

    Stanback, Thomas, Jr.; Drennan, Matthew

    The objective stated for this monograph is to provide some insights regarding the nature of urban economic systems and their growth processes which will be useful in formulating developmental policy. A foreword (by Eli Ginzberg) provides background on the history of and present challenge to reshape manpower policies and programs for cities…

  13. Boot Camp for Education CEOs: The Broad Foundation Superintendents Academy

    ERIC Educational Resources Information Center

    Jehlen, Alain

    2012-01-01

    The Broad Foundation Superintendents Academy is the most prominent and most controversial training institute for school chiefs. The Academy is the flagship program of the Eli and Edythe Broad Foundation, the smallest of a triumvirate of corporate foundations that are at the heart of the billionaire campaign to remake public education in the image…

  14. TESL Reporter, Vol. 11, No. 2.

    ERIC Educational Resources Information Center

    Pack, Alice C., Ed.

    This issue contains the following articles: "Progressive Decontrol through Deletion," by Robert C. Weissberg; "The Scrutable Chinese," by Jason B. Alter; "Gadgets: Some Non-Verbal Tools for Teaching Pronunciation," by Judy Gilbert; "ELI and English Skills in JFS Library-Media Complex," by Curtis Fawson; and "Aural Comprehension: Mini Lessons in…

  15. The Role of the Social Scientist in Human Resource Development Policy and Programs for Hispanics. National Symposium on Hispanics and CETA (1980).

    ERIC Educational Resources Information Center

    Furino, Antonio, Ed.

    Conference speakers focused on three topics: Hispanics and Comprehensive Employment and Training Act (CETA) policy and implementation issues; data sources; and research regarding Hispanic manpower. After introductory remarks by James W. Wagener, Eli Ginzberg and Tomas Rivera, Ernest Green discussed Hispanics and CETA. Harry Greenspan described…

  16. Developing Reading and Writing Skills of Learners' from Arabic-Speaking Backgrounds

    ERIC Educational Resources Information Center

    Fuqua, Jason

    2015-01-01

    The number of native Arabic-speaking students coming to America to study English in university programs has grown over the past few years, and continues to be substantial. It has also been noticed by the English Language Institute (ELI) at Sam Houston State University (SHSU) that these students often struggle more with reading activities in class,…

  17. 16. Forge building and fuel storage shed from the southwest, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. Forge building and fuel storage shed from the southwest, c.1918 Photocopied from a photograph in the collection of William F. Applegate, 43 Grandview Avenue, Wallingford, Connecticut. - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  18. ACS chemical neuroscience molecule spotlight on semagacestat (LY450139).

    PubMed

    Hopkins, Corey R

    2010-08-18

    Semagacestat (LY450139) is a novel γ-secretase inhibitor currently in late-stage development by Eli Lilly and Company as a potential treatment for Alzheimer's disease (AD). Semagacestat is currently being studied in two phase III clinical trials. PMID:22778845

  19. Networked Success and Failure at Hybritech

    ERIC Educational Resources Information Center

    Jones, Mark Peter

    2011-01-01

    The author presents an historical account of scientific work conducted at a commercial biotech firm in San Diego called Hybritech. It tells of disruptions in research programs following the acquisition of the company by the pharmaceutical giant Eli Lilly in 1986. The story centers on responses to an organizational challenge that research managers…

  20. 77 FR 46612 - New Animal Drugs; Change of Sponsor; Change of Sponsor Address; Azaperone; Miconazole, Polymyxin...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-06

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Parts 510, 522, and 524 New Animal Drugs; Change of...) is amending the animal drug regulations to reflect a change of sponsor for two new animal drug applications (NADAs) from Janssen Pharmaceutica NV, to Elanco Animal Health, a Division of Eli Lilly & Co....

  1. Evaluation of Small System Filtration Technologies for the Treatment of Color, Disinfection ByProducts and Microbiological Contaminants in Surface Water

    EPA Science Inventory

    The U.S. Environmental Protection Agency (EPA) National Risk Management Research Laboratory (NRMRL) evaluated various filtration systems at the EPA T&E Facility in Cincinnati, Ohio and at a field site in Ely, Minnesota (MN) in collaboration with the Minnesota Department of Health...

  2. Exploring the Everyday Life Information Needs, Practices, and Challenges of Emerging Adults with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Hanson-Baldauf, Dana

    2013-01-01

    This dissertation research addresses a gap in the library and information science literature on everyday life information (ELI) needs and experiences of emerging adults with intellectual disabilities (I/DD). Emerging adulthood refers to the period between the late teen years and mid-twenties. Although this is a period of significant change for all…

  3. Identification and Characterization of the First Cholesterol-Dependent Cytolysins from Gram-Negative Bacteria

    PubMed Central

    Hotze, Eileen M.; Le, Huynh M.; Sieber, Jessica R.; Bruxvoort, Christina; McInerney, Michael J.

    2013-01-01

    The cholesterol-dependent cytolysins (CDCs) are pore-forming toxins that have been exclusively associated with a wide variety of bacterial pathogens and opportunistic pathogens from the Firmicutes and Actinobacteria, which exhibit a Gram-positive type of cell structure. We have characterized the first CDCs from Gram-negative bacterial species, which include Desulfobulbus propionicus type species Widdel 1981 (DSM 2032) (desulfolysin [DLY]) and Enterobacter lignolyticus (formerly Enterobacter cloacae) SCF1 (enterolysin [ELY]). The DLY and ELY primary structures show that they maintain the signature motifs of the CDCs but lack an obvious secretion signal. Recombinant, purified DLY (rDLY) and ELY (rELY) exhibited cholesterol-dependent binding and cytolytic activity and formed the typical large CDC membrane oligomeric pore complex. Unlike the CDCs from Gram-positive species, which are human- and animal-opportunistic pathogens, neither D. propionicus nor E. lignolyticus is known to be a pathogen or commensal of humans or animals: the habitats of both organisms appear to be restricted to anaerobic soils and/or sediments. These studies reveal for the first time that the genes for functional CDCs are present in bacterial species that exhibit a Gram-negative cell structure. These are also the first bacterial species containing a CDC gene that are not known to inhabit or cause disease in humans or animals, which suggests a role of these CDCs in the defense against eukaryote bacterial predators. PMID:23115036

  4. Oxidation of methionine 216 in sheep and elk prion protein is highly dependent upon the amino acid at position 218 but is not important for prion propagation

    Technology Transfer Automated Retrieval System (TEKTRAN)

    We developed a sensitive mass spectrometry-based method of quantitating the prions present in elk and sheep. Calibration curves relating the area ratios of the selected analyte peptides and their homologous stable isotope labeled internal standards were prepared. This method was compared to the ELIS...

  5. 17. Forge building, fuel storage shed, and foundry, 1906 Photocopied ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. Forge building, fuel storage shed, and foundry, 1906 Photocopied from a photograph by Thomas S. Bronson, 'Group at Whitney Factory, 5 November 1906,' NHCHSL. The most reliable view of the fuel storage sheds and foundry, together with a view of the forge building. - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  6. Diagnostic Trends in Autistic Spectrum Disorders in the South Wales Valleys

    ERIC Educational Resources Information Center

    Latif, A. H. A.; Williams, W. R.

    2007-01-01

    This study provides an analysis of the diagnostic trends in autistic spectrum disorder (ASD) for children aged under 17 years in the Rhondda and Taff Ely districts of South Wales. In the period 1988-2004, 336 children received a diagnosis of ASD and represent the case registry data of one community pediatric team. For the period 1994-2003, the…

  7. The Broad Way

    ERIC Educational Resources Information Center

    Butler, Kevin

    2008-01-01

    In the world of corporate philanthropy, there are those who give to educational causes, and this article describes one such philanthropist, Eli Broad, who shares his take on schools in America. Broad is in a category unto himself not only because of the amount of money he has given--more than $280 million since 1999--but also for his unique…

  8. Laser driven nuclear science and applications: The need of high efficiency, high power and high repetition rate Laser beams

    NASA Astrophysics Data System (ADS)

    Gales, S.

    2015-10-01

    Extreme Light Infrastructure (ELI) is a pan European research initiative selected on the European Strategy Forum on Research Infrastructures Roadmap that aims to close the gap between the existing laboratory-based laser driven research and international facility-grade research centre. The ELI-NP facility, one of the three ELI pillars under construction, placed in Romania and to be operational in 2018, has as core elements a couple of new generation 10 PW laser systems and a narrow bandwidth Compton backscattering gamma source with photon energies up to 19 MeV. ELI-NP will address nuclear photonics, nuclear astrophysics and quantum electrodynamics involving extreme photon fields. Prospective applications of high power laser in nuclear astrophysics, accelerator physics, in particular towards future Accelerator Driven System, as well as in nuclear photonics, for detection and characterization of nuclear material, and for nuclear medicine, will be discussed. Key issues in these research areas will be at reach with significant increase of the repetition rates and of the efficiency at the plug of the high power laser systems as proposed by the ICAN collaboration.

  9. Evolution of the Conditions for Successful Innovation in Remote Networked Schools

    ERIC Educational Resources Information Center

    Hamel, Christine; Turcotte, Sandrine; Laferrière, Thérèse

    2013-01-01

    This paper investigates the presence (or absence) of Ely's (1999) conditions for implementing innovation in a rural context in the province of Quebec (Canada). The innovation, namely the Remote Networked School (RNS) initiative, is designed to bring new technology tools to enrich the learning environment of students and diminish teachers'…

  10. The 2010 Broad Prize

    ERIC Educational Resources Information Center

    Education Digest: Essential Readings Condensed for Quick Review, 2011

    2011-01-01

    A new data analysis, based on data collected as part of The Broad Prize process, provides insights into which large urban school districts in the United States are doing the best job of educating traditionally disadvantaged groups: African-American, Hispanics, and low-income students. Since 2002, The Eli and Edythe Broad Foundation has awarded The…

  11. Broad Prize: Do the Successes Spread?

    ERIC Educational Resources Information Center

    Samuels, Christina A.

    2011-01-01

    When the Broad Prize for Urban Education was created in 2002, billionaire philanthropist Eli Broad said he hoped the awards, in addition to rewarding high-performing school districts, would foster healthy competition; boost the prestige of urban education, long viewed as dysfunctional; and showcase best practices. Over the 10 years the prize has…

  12. Business, Philanthropy, and Education in the United States.

    ERIC Educational Resources Information Center

    Hall, Peter Dobkin

    1994-01-01

    Traces the history of the relationship between business and public education from the 17th century through the depression, the war, and the post-liberal era; and notes the contributions of Eli Whitney, Andrew Carnegie, and other philanthropists. The article also examines the efforts to achieve social transformation through the schools. (SM)

  13. 25. Site plan by New Haven Water Company, c.1900 Photocopied ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    25. Site plan by New Haven Water Company, c.1900 Photocopied from property map, Mill River Division, Sheet 51, Map Collection, Armory Street Filtration Plant, New Haven Water Company, Hamden, Connecticut. - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  14. 26. Site plan of Lake Whitney; detail of original engineering ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    26. Site plan of Lake Whitney; detail of original engineering drawing, 1856 Photocopied from map drawn and surveyed by Nelson J. Welton, C.E., 'Contemplated Waterworks at Whitneyville, 1856,' unaccessioned New Haven Water Company Papers, collection of NHCHSL. Shows 'Whitney's Upper Armory,' 'Clock Shop,' 'E. Whitney's Lower Armory.' - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  15. 22. Lake Whitney Dam, 1895 Photocopied from an original photograph, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. Lake Whitney Dam, 1895 Photocopied from an original photograph, NHCHSL. Shows the rear of the dam building, and on Lake Whitney, Day's Store and Boathouse, and an ice house and steam-powered elevators. - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  16. 8. Town of Hamden, 1852. Photocopied from a photostatic detail ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Town of Hamden, 1852. Photocopied from a photostatic detail in the collection of the Hamden Historical Society, Hamden, Connecticut. From R. Whiteford, 'Map of the County of New Haven, Connecticut' (New Haven, 1852). Shown are 'Witney's sic Armory,' 'Whitney's Marine Clock Factory,' and 'Whitney' s Pistol Factory.' - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  17. Teriparatide for postmenopausal osteoporosis.

    PubMed

    2004-12-01

    Teriparatide (Forsteo - Eli Lilly) is the first parathyroid hormone derivative to be licensed for the treatment of women with postmenopausal osteoporosis. It is described as a "bone-formation agent", in contrast to established treatments, such as bisphosphonates, raloxifene, calcitriol and calcitonin, which reduce bone resorption. Here we consider whether teriparatide offers any worthwhile advantages over these other options. PMID:15587764

  18. Adaptation of Rural and Foreign Workers to Industry, International Joint Seminar (Wiesbaden, December 10-13, 1963). Final Report. International Seminars 1963-4.

    ERIC Educational Resources Information Center

    Organisation for Economic Cooperation and Development, Paris (France). Social Affairs Div.

    The major purpose of a seminar held in Wiesbaden, Germany, was to exchange experiences and views on the methods of expediating adjustment of rural and foreign workers to industry. Major presentations for discussion were "Internal Migration" by Magda Talamo, and "International Migration" by Elie Dimitras. Some conclusions were: (1) Movement of the…

  19. 11. Whitney's Armory, Near New Haven, Ct., 1842 Photocopied from ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Whitney's Armory, Near New Haven, Ct., 1842 Photocopied from a woodcut in Henry Howe, Memoirs of the Most Eminent American Mechanics (New York, 1842), p. 124. The best early view of the filing shop and its raceway. See footnote 58. - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  20. Child Abuse and Neglect: The Proceedings of an Interdisciplinary Workshop on Child Abuse.

    ERIC Educational Resources Information Center

    Department of Health, Education, and Welfare, Washington, DC.

    Proceedings of a workshop on the need to establish a close working relationship between the medical, legal, and social work professions in the management of child abuse is presented. An introduction by Frank Beal is followed by welcoming remarks by Pennsylvania Governor Milton Shapp. Speeches by Elizabeth Davoren, Eli Newberger, and Vincent…

  1. 9. Town of Hamden, 1868 Map detail photocopied from F. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Town of Hamden, 1868 Map detail photocopied from F. W. Beers, et al., Atlas of New Haven County, Connecticut (New York, 1868), p. 25. Shows the newly created Lake Whitney and, one quarter mile south of the armory, a 'Rifle Factory.' - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  2. Drug Advertising and the FDA.

    ERIC Educational Resources Information Center

    Levesque, Cynthia

    With increases in consumer focused advertising for prescription drugs, the Federal Drug Administration has renewed efforts to protect the public from false advertising. In 1982, it charged that the press kits Eli Lilly and Company distributed to reporters on its new antiarthritis drug, Oraflex, misrepresented the product. It recommended that Lilly…

  3. 75 FR 1408 - Notice of Availability of the Record of Decision for the Lincoln County Land Act Groundwater...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-11

    ...The Bureau of Land Management (BLM) announces the availability of the Record of Decision (ROD) for the Lincoln County Land Act Groundwater Development and Utility Right-of-Way (ROW) Project (the project). The BLM Ely District Manager signed the ROD on January 8, 2010, which constitutes the final decision of the BLM and makes the decision effective...

  4. Reactivity Differences between [alpha, beta]-Unsaturated Carbonyls and Hydrazones Investigated by Experimental and Theoretical Electron Density and Electron Localizability Analyses

    SciTech Connect

    Grabowsky, Simon; Weber, Manuela; Jayatilaka, Dylan; Chen, Yu-Sheng; Grabowski, Matthias T.; Brehme, Rainer; Hesse, Malte; Schirmeister, Tanja; Luger, Peter

    2012-10-11

    It is still a challenge to predict a compound's reactivity from its ground-state electronic nature although Bader-type topological analyses of the electron density (ED) and electron localizability indicator (ELI) give detailed and useful information on electron concentration and electron-pair localization, respectively. Both ED and ELI can be obtained from theoretical calculations as well as high-resolution X-ray diffraction experiments. Besides ED and ELI descriptors, the delocalization index is used here; it is likewise derived from theoretical calculations as well as from experimental X-ray results, but in the latter case, demonstrated here for the first time. We investigate {alpha},{beta}-unsaturated carbonyl and hydrazone compounds because resonance exhibited by these compounds in the electronic ground-state determines their reactive behavior. The degree of resonance as well as the reactivity contrast are quantified with the electronic descriptors. Moreover, competitive mesomeric substituent effects are studied using the two biologically important compounds acrolein and acrylamide. The reactivity differences predicted from the analyses are in line with the known reactivity of these compounds in organic synthesis. Hence, the capability of the ED and ELI for rationalizing and predicting different and competing substituent effects with respect to reactivity is demonstrated.

  5. A Study on Correlation of Risk-Taking and the Oral Production of English Majors in China

    ERIC Educational Resources Information Center

    Wang, Yang; Lin, Yuewu

    2015-01-01

    Risk-taking refers to the tendency to engage in behaviors that have the potential to be harmful or dangerous, yet at the same time provides the opportunity for some kinds of outcome that can be perceived as positive. Ely (1986) and Bang (1999) have mentioned the relationship between risk-taking and oral production in the process of English…

  6. 75 FR 54019 - New Animal Drugs for Use in Animal Feed; Ractopamine

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-03

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 558 New Animal Drugs for Use in Animal Feed... Administration (FDA) is amending the animal drug regulations to reflect approval of two supplemental new animal drug applications (NADAs) filed by Elanco Animal Health, A Division of Eli Lilly & Co. The...

  7. 75 FR 5887 - New Animal Drugs for Use in Animal Feeds; Ractopamine; Monensin

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-05

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 558 New Animal Drugs for Use in Animal Feeds... Drug Administration (FDA) is amending the animal drug regulations to reflect approval of an original new animal drug application (NADA) filed by Elanco Animal Health, A Division of Eli Lilly & Co....

  8. ECO LOGIC INTERNATIONAL GAS-PHASE CHEMICAL REDUCTION PROCESS - THE REACTOR SYSTEM - APPLICATIONS ANALYSIS REPORT

    EPA Science Inventory

    The ELI Eco Logic International Inc. (Eco Logic) process thermally separates organics, then chemically reduces them in a hydrogen atmosphere, converting them to a reformed gas that consists of light hydrocarbons and water. A scrubber treats the reformed gas to remove hydrogen chl...

  9. Grow Your Own School Leaders: A Case Study of Principal Development in Philadelphia Schools

    ERIC Educational Resources Information Center

    Urban Education Collaborative, 2010

    2010-01-01

    In 2004-05, the School District of Philadelphia (SDP) began a groundbreaking partnership with the Eli Broad Foundation to develop the Academy for Leadership in Philadelphia Schools (ALPS), one of several Broad-funded, alternative principal development programs initiated across the country. The ALPS effort was designed to respond to two challenges:…

  10. Comprehensive multiphase NMR: a promising technology to study plants in their native state.

    PubMed

    Wheeler, Heather L; Soong, Ronald; Courtier-Murias, Denis; Botana, Adolfo; Fortier-Mcgill, Blythe; Maas, Werner E; Fey, Michael; Hutchins, Howard; Krishnamurthy, Sridevi; Kumar, Rajeev; Monette, Martine; Stronks, Henry J; Campbell, Malcolm M; Simpson, Andre

    2015-09-01

    Nuclear magnetic resonance (NMR) spectroscopy is arguably one the most powerful tools to study the interactions and molecular structure within plants. Traditionally, however, NMR has developed as two separate fields, one dealing with liquids and the other dealing with solids. Plants in their native state contain components that are soluble, swollen, and true solids. Here, a new form of NMR spectroscopy, developed in 2012, termed comprehensive multiphase (CMP)-NMR is applied for plant analysis. The technology composes all aspects of solution, gel, and solid-state NMR into a single NMR probe such that all components in all phases in native unaltered samples can be studied and differentiated in situ. The technology is evaluated using wild-type Arabidopsis thaliana and the cellulose-deficient mutant ectopic lignification1 (eli1) as examples. Using CMP-NMR to study intact samples eliminated the bias introduced by extraction methods and enabled the acquisition of a more complete structural and metabolic profile; thus, CMP-NMR revealed molecular differences between wild type (WT) and eli1 that could be overlooked by conventional methods. Methanol, fatty acids and/or lipids, glutamine, phenylalanine, starch, and nucleic acids were more abundant in eli1 than in WT. Pentaglycine was present in A. thaliana seedlings and more abundant in eli1 than in WT. PMID:25855560

  11. 35. SOUTHEAST TO CIRCA 1910 BROACHING MACHINE USED TO CUT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    35. SOUTHEAST TO CIRCA 1910 BROACHING MACHINE USED TO CUT KEYWAYS IN SUCH CAST IRON PARTS AS THE CRANK PLATES FOR ELI WINDMILLS AFTER THEY WERE MACHINED ON ONE OF THE LATHES. - Kregel Windmill Company Factory, 1416 Central Avenue, Nebraska City, Otoe County, NE

  12. Issues and Developments in English and Applied Linguistics (IDEAL), 1994.

    ERIC Educational Resources Information Center

    Dickerson, Wayne B., Ed.; Kachru, Yamuna, Ed.

    1994-01-01

    Seven papers on topics of English-as-a-Second-Language (ESL) instruction, language research, and applied linguistics are presented: "ESL Students and Common L2 Conversation-Making Expressions" (Eli Hinkel); "Thematic Options in Reporting Previous Research" (Sarah Thomas, Thomas Hawes); "Connected Speech Modifications in the English of Japanese ESL…

  13. Computer Chips and Paper Clips. Technology and Women's Employment. Volume II. Case Studies and Policy Perspectives.

    ERIC Educational Resources Information Center

    Hartmann, Heidi I., Ed.; And Others

    This volume contains 12 papers commissioned by the Panel on Technology and Women's Employment. "Technology, Women, and Work: Policy Perspectives" (Eli Ginzberg) is an overview that provides a context for the volume. The four case studies in Part II describe the impact of information technology in the insurance industry, among bookkeepers, among…

  14. Seizure Risk in Patients with Attention-Deficit-Hyperactivity Disorder Treated with Atomoxetine

    ERIC Educational Resources Information Center

    Wernicke, Joachim F.; Holdridge, Karen Chilcott; Jin, Ling; Edison, Timothy; Zhang, Shuyu; Bangs, Mark E.; Allen, Albert J.; Ball, Susan; Dunn, David

    2007-01-01

    The comorbidity of seizures, epilepsy, and attention-deficit-hyperactivity disorder (ADHD) prompted the examination of whether atomoxetine use for ADHD is associated with an increased risk of seizures. Seizures and seizure-related symptoms were reviewed from two independent Eli Lilly and Company databases: the atomoxetine clinical trials database…

  15. Rooting Response of Azalea Cultivars Using Hot Water Treatments to Control Pathogens

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Azalea web blight is an annual problem on some evergreen azalea cultivars grown in containerized nursery production in the southern and eastern United States. The binucleate Rhizoctonia species, which cause the disease, are spread on new shoot growth harvested for propagation. Rhizoctonia can be eli...

  16. 15. Site plan, 1915, bottom half With CT214, photocopied from ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. Site plan, 1915, bottom half With CT-2-14, photocopied from an ozalid print, 'Map of Plant of Sentinel Manufacturing Co.,' Folio 2, EWC. The Sentinel Manufacturing Co. produced gas stoves. They leased the Whitney Armory buildings about 1915. - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  17. Promoting Early Literacy Skills within Daily Activities and Routines in Preschool Classrooms

    ERIC Educational Resources Information Center

    Chandler, Lynette K.; Young, Robin Miller; Nylander, Donna; Shields, LuAnn; Ash, JoAnne; Bauman, Becky; Butts, Jill; Black, Kristine; Geraghty, Peggy; Hafer, Megan; Lay, Angie; Mitera, Brandie; Richardson, Debra; Steffen, Kara; Summers, Debra

    2008-01-01

    Many teachers and other service providers struggle with trying to address the many skills that are important for young children to acquire during the preschool years. Early Literacy Initiative project (Project ELI) is a comprehensive, two-tiered, early language and literacy intervention model that includes activities for all children as well as…

  18. 61. DETAIL OF HEAD, VANE STEM, VANE HINGE, AND WHEEL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    61. DETAIL OF HEAD, VANE STEM, VANE HINGE, AND WHEEL OF AN ELI WINDMILL ON THE GROUND AT THE STOLL RESIDENCE ABOUT 1-1/2 MILES WEST OF NEBRASKA CITY ON STEAM WAGON ROAD. - Kregel Windmill Company Factory, 1416 Central Avenue, Nebraska City, Otoe County, NE

  19. Academic Freedom on Trial: 100 Years of Sifting and Winnowing at the University of Wisconsin-Madison.

    ERIC Educational Resources Information Center

    Hansen, W. Lee, Ed.

    The 29 papers in this collection celebrate academic freedom at the University of Wisconsin-Madison and are organized around the 1894 "trial" of Richard T. Ely, an economist who was exonerated of fomenting unrest and discussing "dangerous" ideas in a Board of Regents Statement which stressed the importance of "sifting and winnowing" ideas to…

  20. Fatigue Life of Titanium Alloys Fabricated by Additive Layer Manufacturing Techniques for Dental Implants

    NASA Astrophysics Data System (ADS)

    Chan, Kwai S.; Koike, Marie; Mason, Robert L.; Okabe, Toru

    2013-02-01

    Additive layer deposition techniques such as electron beam melting (EBM) and laser beam melting (LBM) have been utilized to fabricate rectangular plates of Ti-6Al-4V with extra low interstitial (ELI) contents. The layer-by-layer deposition techniques resulted in plates that have different surface finishes which can impact significantly on the fatigue life by providing potential sites for fatigue cracks to initiate. The fatigue life of Ti-6Al-4V ELI alloys fabricated by EBM and LBM deposition techniques was investigated by three-point testing of rectangular beams of as-fabricated and electro-discharge machined surfaces under stress-controlled conditions at 10 Hz until complete fracture. Fatigue life tests were also performed on rolled plates of Ti-6Al-4V ELI, regular Ti-6Al-4V, and CP Ti as controls. Fatigue surfaces were characterized by scanning electron microscopy to identify the crack initiation site in the various types of specimen surfaces. The fatigue life data were analyzed statistically using both analysis of variance techniques and the Kaplan-Meier survival analysis method with the Gehan-Breslow test. The results indicate that the LBM Ti-6Al-4V ELI material exhibits a longer fatigue life than the EBM counterpart and CP Ti, but a shorter fatigue life compared to rolled Ti-6Al-4V ELI. The difference in the fatigue life behavior may be largely attributed to the presence of rough surface features that act as fatigue crack initiation sites in the EBM material.

  1. Lenticular stretch structures in eastern Nevada - possible trapping mechanism in supposed graben

    SciTech Connect

    Walker, C.T.; Dennis, J.G.; Lumsden, W.W.

    1986-04-01

    Eastern Nevada is widely recognized as a region of tectonic extension. The dominant structures are generally agreed to be low-dipping, younger over older faults and steeper listric faults that are responsible for the basins (grabens) and ranges (horsts). In the Schell Creek-Duck Creek Range, east of Ely, and in the White Pine Range, southwest of Ely, small lenticular structures bounded by tectonic discontinuities can be clearly seen in the field. These lenticular units, or stretch structures, range in length from a few meters to more than 200 m. All lenticular stretch structures that can be clearly seen in the field are stratigraphically restricted; the stretched formations are the Eureka Quartzite, the Pilot Shale, the Joana Limestone, and the Chainman Shale. Still larger stretch structures, which may include several formations, are inferred, and the authors suggest that extension has created lenticular structures at all scales. The Duck Creek and Schell Creek Ranges east of Ely consist mostly of Devonian and older rocks. They are separated by a topographically lower area containing mostly Mississippian and Pennsylvanian rocks. This structure, which separates the ranges, has been referred to as a graben, but field evidence suggests that it is a large-scale lenticular stretch structure. Unlike a true graben, the structure does not extend downward. For example, in several places within the supposed graben, Cambrian and Ordovician rocks project through a cover of Carboniferous Chainman Shale and Ely Limestone, suggesting the Chainman-Ely is a thin sheet underlain by Cambrian-Ordovician rocks. Accordingly, they suggest that extension in the Duck Creek-Schell Creek Ranges stretched the formations into lenticular bodies. Between the Duck Creek and Schell Creek Ranges, the Cambrian-Ordovician is attenuated, and the resulting tectonic depression is occupied by a lenticular mass of Carboniferous rocks.

  2. Pre-transplant assessment of CMV-specific immune response by Elispot assay in kidney transplant recipients.

    PubMed

    Rittà, Massimo; Costa, Cristina; Sidoti, Francesca; Ballocco, Cinzia; Ranghino, Andrea; Messina, Maria; Biancone, Luigi; Cavallo, Rossana

    2015-07-01

    Cytomegalovirus (CMV) primary infection or re-activation in solid organ transplant (SOT) recipients is associated with increased morbidity and mortality, with patients with IgG-CMV D+/R- sero-matching at greater risk. The impact of pre-transplant CMV-specific host cellular immunity on the long-term risk of CMV replication in kidney transplants (KT) was prospectively evaluated in eighty patients by CMV-EliSpot assay. The study population included 54 male and 26 female recipients, with CMV-IgG distribution: 60 D+/R+, 11 D-/R+, 7 D+/R-, 2 D-/R-. At pre-transplantation, 49 KT (61.3%) were CMV-responders by EliSpot. At 3-month follow up, 16 (32.7%) out of 49 CMV-responders showed CMV blood infection, compared to 8 (25.8%) out of 31 non-responders. No further episode of CMV viraemia was reported in the responder group, in comparison to 15 out 31 non-responders (48.4%) showing at least one episode of CMV-DNAemia at 12-month follow-up. Baseline CMV-IgG serology showed a strong correlation with EliSpot determinations; KT recipients exhibiting at least one episode of CMV viraemia at 12-month follow-up showed lower baseline CMV-EliSpot values than those without signs of CMV replication. The study suggests that monitoring CMV-specific T-cell responses at pre-transplantation by EliSpot assay may be useful for predicting the post-transplantation risk of CMV infection and reactivation. PMID:26147141

  3. Mid-peripheral collisions around the Fermi energy: comparison with an event generator

    NASA Astrophysics Data System (ADS)

    Hudan, Sylvie; McIntosh, A. B.; Gosser, Z.; Metelko, C.; Rudolph, M.; Yanez, R.; de Souza, R.; Chbihi, A.; Famiano, M.; Fregeau, M. O.; Gauthier, J.; Moisan, J.; Roy, R.; Bianchin, S.; Schwarz, C.; Trautmann, W.; Durand, D.

    2009-05-01

    The reactions ^124Xe+^112,124Sn at E/A=50MeV have been recently measured. For mid-peripheral collisions, the projectile-like-fragment has been measured in coincidence with emitted particles (charged particles and neutrons). Experimental data will be compared to those obtained by the event generator Elie[1]. This two-step event generator consists of an entrance channel phase using a random process to determine the initial partition; and of kinematic propagation and secondary decay as the second phase. Experimental and generated energy distributions, angular distributions, and Z distributions of charged products will be examined. Yields of isotopically resolved fragments will be studied, including the effect of the target N/Z. [1] Elie: an event generator for nuclear reactions, Dominique Durand, arXiv:0803.2159

  4. A comparison of glide force characteristics between 2 prefilled insulin lispro pens.

    PubMed

    Rees, Tina M; Lennartz, Amanda H; Ignaut, Debra A

    2015-03-01

    Glide force, average glide force, and glide force variability of the insulin lispro 200 units/mL pen (Eli Lilly and Company, Indianapolis, IN, USA) were compared to the Humalog KwikPen 100 units/mL pen (hereafter, KwikPen; Eli Lilly and Company, Indianapolis, IN, USA). Data were collected on 2 doses, 2 injection speeds, and 2 needle types. Insulin lispro 200 units/mL pen showed significantly lower maximum glide force, average glide force, and glide force variability than the KwikPen across all combinations of dose size, dose speed, and needle type. The lower glide force observed with the insulin lispro 200 units/mL pen offers another treatment option for patients with type 1 or type 2 diabetes who require greater than 20 units of mealtime insulin daily. PMID:25591858

  5. Investigation of the fracture mechanism in Ti-5Al-2.5Sn at cryogenic temperatures

    NASA Technical Reports Server (NTRS)

    Vanstone, R. H.; Low, J. R., Jr.; Shannon, J. L., Jr.

    1977-01-01

    The influence of microstructure on the fracture mechanism and plane-strain fracture toughness of Ti-5Al-2.5Sn was studied through the use of fractography and metallographic sectioning techniques. One-inch thick plates of extra low interstitial (ELI) and normal interstitial Ti-5Al-2.5Sn were mill annealed at 815 C followed by either air or furnace cooling. These variations in composition and cooling rate resulted in differences in the volume fraction and internal structure of the iron-stabilized phase, and in the crystallographic texture and ordering of the alpha matrix. The tensile properties of these plates were determined at 20 K, 77 K, and 295 K. The air-cooled ELI plate was the toughest material evaluated.

  6. Stress Corrosion Cracking and Fatigue Crack Growth Studies Pertinent to Spacecraft and Booster Pressure Vessels

    NASA Technical Reports Server (NTRS)

    Hall, L. R.; Finger, R. W.

    1972-01-01

    This experimental program was divided into two parts. The first part evaluated stress corrosion cracking in 2219-T87 aluminum and 5Al-2.5Sn (ELI) titanium alloy plate and weld metal. Both uniform height double cantilever beam and surface flawed specimens were tested in environments normally encountered during the fabrication and operation of pressure vessels in spacecraft and booster systems. The second part studied compatibility of material-environment combinations suitable for high energy upper stage propulsion systems. Surface flawed specimens having thicknesses representative of minimum gage fuel and oxidizer tanks were tested. Titanium alloys 5Al-2.5Sn (ELI), 6Al-4V annealed, and 6Al-4V STA were tested in both liquid and gaseous methane. Aluminum alloy 2219 in the T87 and T6E46 condition was tested in fluorine, a fluorine-oxygen mixture, and methane. Results were evaluated using modified linear elastic fracture mechanics parameters.

  7. The emerging role of pemetrexed (Alimta) and gemcitabine in non-small cell lung cancer.

    PubMed

    Le Chevalier, Thierry

    2003-08-01

    In recent years, several new cytotoxic agents have been investigated for the management of non-small cell lung cancer (NSCLC), including the antimetabolic gemcitabine (Gemzar; Eli Lilly and Company, Indianapolis, IN) and the new multitargeted antifolate pemetrexed (Alimta, Eli Lilly and Company), which are both among the most active agents in advanced NSCLC. Gemcitabine has become one of the key drugs in the management of NSCLC, alone or in association with platin compounds. Promising results have also been reported with pemetrexed used as a single-agent or in combination with cisplatin or gemcitabine. These results indicate that pemetrexed may also play a vital role in the treatment of NSCLC, malignant mesothelioma, and other solid tumors. Ongoing (and planned) trials are investigating the use of single-agent pemetrexed, or combinations with cisplatin, gemcitabine, and other cytotoxic agents in various malignancies. PMID:12947960

  8. Photoneutron cross section measurements on Sm isotopes

    NASA Astrophysics Data System (ADS)

    Filipescu, D.; Utsunomiya, H.; Camera, F.; Nyhus, H. T.; Renstrøm, T.; Gheorghe, I.; Glodariu, T.; Tesileanu, O.; Goriely, S.; Lui, Y. W.; Shima, T.; Takahisa, K.; Miyamoto, S.

    2015-05-01

    The Extreme Light Infrastructure - Nuclear Physics, one of the three pillars of the Extreme Light Infrastructure Pan-European initiative, is a new large scale facility dedicated to nuclear physics with extreme electromagnetic fields. ELI-NP will host two 10 PW lasers and a very brilliant Gamma beam system with unprecedented intensity and energy resolution parameters. We propose to perform photon induced nuclear reactions using the very brilliant γ-ray beams provided by the Gamma beam system to examine in detail the photon absorption process and its decay modes. Here the experimental program related to nuclear research on reactions above the neutron separation threshold, which is under preparation at ELI-NP, is presented.

  9. Empowering the Community to Manage Diabetes Better: An Integrated Partnership-Based Model

    PubMed Central

    Bamne, Arun; Shah, Daksha; Palkar, Sanjivani; Uppal, Shweta; Majumdar, Anurita; Naik, Rohan

    2016-01-01

    Context Rising number of diabetes cases in India calls for collaboration between the public and private sectors. Aims: Municipal Corporation of Greater Mumbai (MCGM) partnered with Eli Lilly and Company (India) [Eli Lilly] to strengthen the capacity of their diabetes clinics. Materials and Methods Medical Officers, dispensaries and Assistant Medical Officers (AMOs) located at attached health posts were trained on an educational tool, Diabetes Conversation Map™ (DCM) by a Master Trainer. This tool was then used to educate patients and caregivers visiting the MCGM diabetes clinics. Results Twenty-eight centers conducted 168 sessions, and 1616 beneficiaries availed the education over six months. General feedback from health providers was that DCM helps clear misconceptions among patients and caregivers in an interactive way and also improves compliance of patients. Conclusions This communication highlights a unique public-private partnership where the sincere efforts of public sector organization (MCGM) were complemented by the educational expertise lent by a private firm. PMID:27051094

  10. Management of the Essex-Lopresti Injury.

    PubMed

    Matson, Andrew P; Ruch, David S

    2016-08-01

    Essex-Lopresti injuries (ELIs) are characterized by fracture of the radial head, disruption of the forearm interosseous membrane, and dislocation of the distal radioulnar joint. This injury pattern results in axial and longitudinal instability of the forearm. Initial radiographs may fail to reveal the full extent of the injury, and therefore diagnosis in the acute setting requires a high index of suspicion. Early recognition and treatment are preferred as failure to fully treat the problem may result in chronic wrist pain from ulnar abutment or chronic elbow pain from radiocapitellar arthrosis. In this article the presentation, relevant anatomy, and management options for ELIs are overviewed, and a summary of outcomes reported in the literature is provided. Additionally, the preferred surgical technique of the senior author is presented, which involves reconstruction of the interosseous membrane with a local pronator rerouting autograft. PMID:27468366