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Sample records for based 99mtc generator

  1. Metadata based mediator generation

    SciTech Connect

    Critchlow, T

    1998-03-01

    Mediators are a critical component of any data warehouse, particularly one utilizing partially materialized views; they transform data from its source format to the warehouse representation while resolving semantic and syntactic conflicts. The close relationship between mediators and databases, requires a mediator to be updated whenever an associated schema is modified. This maintenance may be a significant undertaking if a warehouse integrates several dynamic data sources. However, failure to quickly perform these updates significantly reduces the reliability of the warehouse because queries do not have access to the m current data. This may result in incorrect or misleading responses, and reduce user confidence in the warehouse. This paper describes a metadata framework, and associated software designed to automate a significant portion of the mediator generation task and thereby reduce the effort involved in adapting the schema changes. By allowing the DBA to concentrate on identifying the modifications at a high level, instead of reprogramming the mediator, turnaround time is reduced and warehouse reliability is improved.

  2. Photography-based image generator

    NASA Astrophysics Data System (ADS)

    Dalton, Nicholas M.; Deering, Charles S.

    1989-09-01

    A two-channel Photography Based Image Generator system was developed to drive the Helmet Mounted Laser Projector at the Naval Training System Center at Orlando, Florida. This projector is a two-channel system that displays a wide field-of-view color image with a high-resolution inset to efficiently match the pilot's visual capability. The image generator is a derivative of the LTV-developed visual system installed in the A-7E Weapon System Trainer at NAS Cecil Field. The Photography Based Image Generator is based on patented LTV technology for high resolution, multi-channel, real world visual simulation. Special provisions were developed for driving the NTSC-developed and patented Helmet Mounted Laser Projector. These include a special 1023-line raster format, an electronic image blending technique, spherical lens mapping for dome projection, a special computer interface for head/eye tracking and flight parameters, special software, and a number of data bases. Good gaze angle tracking is critical to the use of the NTSC projector in a flight simulation environment. The Photography Based Image Generator provides superior dynamic response by performing a relatively simple perspective transformation on stored, high-detail photography instead of generating this detail by "brute force" computer image generation methods. With this approach, high detail can be displayed and updated at the television field rate (60 Hz).

  3. Computer-based structure generation

    NASA Astrophysics Data System (ADS)

    Korytko, Andrey A.

    The program HOUDINI has been designed to construct all structures consistent with structural implications of spectroscopic and other properties of an unknown molecule. With the advent of HOUDINI, a new method of computer structure generation, called convergent structure generation, has been developed that addresses the limitations of earlier methods. Several features of HOUDINI are noteworthy: an integrated application of the collective substructural information; the use of parallel atom groups for a highly efficient handling of alternative substructural inferences; and a managed structure generation procedure designed to build required structural features early in the process. A number of complex structure elucidation problems were solved using the HOUDINI-based comprehensive structure elucidation system. The program performance suggests that convergent structure generation is effective in solving structure problems where much of the input to the structure generator is highly ambiguous, i.e., expressed as families of alternative substructural inferences.

  4. Micromotor-based energy generation.

    PubMed

    Singh, Virendra V; Soto, Fernando; Kaufmann, Kevin; Wang, Joseph

    2015-06-01

    A micromotor-based strategy for energy generation, utilizing the conversion of liquid-phase hydrogen to usable hydrogen gas (H2), is described. The new motion-based H2-generation concept relies on the movement of Pt-black/Ti Janus microparticle motors in a solution of sodium borohydride (NaBH4) fuel. This is the first report of using NaBH4 for powering micromotors. The autonomous motion of these catalytic micromotors, as well as their bubble generation, leads to enhanced mixing and transport of NaBH4 towards the Pt-black catalytic surface (compared to static microparticles or films), and hence to a substantially faster rate of H2 production. The practical utility of these micromotors is illustrated by powering a hydrogen-oxygen fuel cell car by an on-board motion-based hydrogen and oxygen generation. The new micromotor approach paves the way for the development of efficient on-site energy generation for powering external devices or meeting growing demands on the energy grid. PMID:25906739

  5. Wavelet-Based Grid Generation

    NASA Technical Reports Server (NTRS)

    Jameson, Leland

    1996-01-01

    Wavelets can provide a basis set in which the basis functions are constructed by dilating and translating a fixed function known as the mother wavelet. The mother wavelet can be seen as a high pass filter in the frequency domain. The process of dilating and expanding this high-pass filter can be seen as altering the frequency range that is 'passed' or detected. The process of translation moves this high-pass filter throughout the domain, thereby providing a mechanism to detect the frequencies or scales of information at every location. This is exactly the type of information that is needed for effective grid generation. This paper provides motivation to use wavelets for grid generation in addition to providing the final product: source code for wavelet-based grid generation.

  6. Simulation-Based Rule Generation Considering Readability

    PubMed Central

    Yahagi, H.; Shimizu, S.; Ogata, T.; Hara, T.; Ota, J.

    2015-01-01

    Rule generation method is proposed for an aircraft control problem in an airport. Designing appropriate rules for motion coordination of taxiing aircraft in the airport is important, which is conducted by ground control. However, previous studies did not consider readability of rules, which is important because it should be operated and maintained by humans. Therefore, in this study, using the indicator of readability, we propose a method of rule generation based on parallel algorithm discovery and orchestration (PADO). By applying our proposed method to the aircraft control problem, the proposed algorithm can generate more readable and more robust rules and is found to be superior to previous methods. PMID:27347501

  7. Simulation-Based Rule Generation Considering Readability.

    PubMed

    Yahagi, H; Shimizu, S; Ogata, T; Hara, T; Ota, J

    2015-01-01

    Rule generation method is proposed for an aircraft control problem in an airport. Designing appropriate rules for motion coordination of taxiing aircraft in the airport is important, which is conducted by ground control. However, previous studies did not consider readability of rules, which is important because it should be operated and maintained by humans. Therefore, in this study, using the indicator of readability, we propose a method of rule generation based on parallel algorithm discovery and orchestration (PADO). By applying our proposed method to the aircraft control problem, the proposed algorithm can generate more readable and more robust rules and is found to be superior to previous methods. PMID:27347501

  8. Error Generation in CATS-Based Agents

    NASA Technical Reports Server (NTRS)

    Callantine, Todd

    2003-01-01

    This research presents a methodology for generating errors from a model of nominally preferred correct operator activities, given a particular operational context, and maintaining an explicit link to the erroneous contextual information to support analyses. It uses the Crew Activity Tracking System (CATS) model as the basis for error generation. This report describes how the process works, and how it may be useful for supporting agent-based system safety analyses. The report presents results obtained by applying the error-generation process and discusses implementation issues. The research is supported by the System-Wide Accident Prevention Element of the NASA Aviation Safety Program.

  9. Ontology-Based Multiple Choice Question Generation

    PubMed Central

    Al-Yahya, Maha

    2014-01-01

    With recent advancements in Semantic Web technologies, a new trend in MCQ item generation has emerged through the use of ontologies. Ontologies are knowledge representation structures that formally describe entities in a domain and their relationships, thus enabling automated inference and reasoning. Ontology-based MCQ item generation is still in its infancy, but substantial research efforts are being made in the field. However, the applicability of these models for use in an educational setting has not been thoroughly evaluated. In this paper, we present an experimental evaluation of an ontology-based MCQ item generation system known as OntoQue. The evaluation was conducted using two different domain ontologies. The findings of this study show that ontology-based MCQ generation systems produce satisfactory MCQ items to a certain extent. However, the evaluation also revealed a number of shortcomings with current ontology-based MCQ item generation systems with regard to the educational significance of an automatically constructed MCQ item, the knowledge level it addresses, and its language structure. Furthermore, for the task to be successful in producing high-quality MCQ items for learning assessments, this study suggests a novel, holistic view that incorporates learning content, learning objectives, lexical knowledge, and scenarios into a single cohesive framework. PMID:24982937

  10. Ontology-based multiple choice question generation.

    PubMed

    Al-Yahya, Maha

    2014-01-01

    With recent advancements in Semantic Web technologies, a new trend in MCQ item generation has emerged through the use of ontologies. Ontologies are knowledge representation structures that formally describe entities in a domain and their relationships, thus enabling automated inference and reasoning. Ontology-based MCQ item generation is still in its infancy, but substantial research efforts are being made in the field. However, the applicability of these models for use in an educational setting has not been thoroughly evaluated. In this paper, we present an experimental evaluation of an ontology-based MCQ item generation system known as OntoQue. The evaluation was conducted using two different domain ontologies. The findings of this study show that ontology-based MCQ generation systems produce satisfactory MCQ items to a certain extent. However, the evaluation also revealed a number of shortcomings with current ontology-based MCQ item generation systems with regard to the educational significance of an automatically constructed MCQ item, the knowledge level it addresses, and its language structure. Furthermore, for the task to be successful in producing high-quality MCQ items for learning assessments, this study suggests a novel, holistic view that incorporates learning content, learning objectives, lexical knowledge, and scenarios into a single cohesive framework. PMID:24982937

  11. Coal based electric generation comparative technologies report

    SciTech Connect

    Not Available

    1989-10-26

    Ohio Clean Fuels, Inc., (OCF) has licensed technology that involves Co-Processing (Co-Pro) poor grade (high sulfur) coal and residual oil feedstocks to produce clean liquid fuels on a commercial scale. Stone Webster is requested to perform a comparative technologies report for grassroot plants utilizing coal as a base fuel. In the case of Co-Processing technology the plant considered is the nth plant in a series of applications. This report presents the results of an economic comparison of this technology with other power generation technologies that use coal. Technologies evaluated were:Co-Processing integrated with simple cycle combustion turbine generators, (CSC); Co-Processing integrated with combined cycle combustion turbine generators, (CCC); pulverized coal-fired boiler with flue gas desulfurization and steam turbine generator, (PC) and Circulating fluidized bed boiler and steam turbine generator, (CFB). Conceptual designs were developed. Designs were based on approximately equivalent net electrical output for each technology. A base case of 310 MWe net for each technology was established. Sensitivity analyses at other net electrical output sizes varying from 220 MWe's to 1770 MWe's were also performed. 4 figs., 9 tabs.

  12. Design Study: Rocket Based MHD Generator

    NASA Technical Reports Server (NTRS)

    1997-01-01

    This report addresses the technical feasibility and design of a rocket based MHD generator using a sub-scale LOx/RP rocket motor. The design study was constrained by assuming the generator must function within the performance and structural limits of an existing magnet and by assuming realistic limits on (1) the axial electric field, (2) the Hall parameter, (3) current density, and (4) heat flux (given the criteria of heat sink operation). The major results of the work are summarized as follows: (1) A Faraday type of generator with rectangular cross section is designed to operate with a combustor pressure of 300 psi. Based on a magnetic field strength of 1.5 Tesla, the electrical power output from this generator is estimated to be 54.2 KW with potassium seed (weight fraction 3.74%) and 92 KW with cesium seed (weight fraction 9.66%). The former corresponds to a enthalpy extraction ratio of 2.36% while that for the latter is 4.16%; (2) A conceptual design of the Faraday MHD channel is proposed, based on a maximum operating time of 10 to 15 seconds. This concept utilizes a phenolic back wall for inserting the electrodes and inter-electrode insulators. Copper electrode and aluminum oxide insulator are suggested for this channel; and (3) A testing configuration for the sub-scale rocket based MHD system is proposed. An estimate of performance of an ideal rocket based MHD accelerator is performed. With a current density constraint of 5 Amps/cm(exp 2) and a conductivity of 30 Siemens/m, the push power density can be 250, 431, and 750 MW/m(sup 3) when the induced voltage uB have values of 5, 10, and 15 KV/m, respectively.

  13. Statistical filtering for NMR based structure generation

    PubMed Central

    2011-01-01

    The constitutional assignment of natural products by NMR spectroscopy is usually based on 2D NMR experiments like COSY, HSQC, and HMBC. The difficulty of a structure elucidation problem depends more on the type of the investigated molecule than on its size. Saturated compounds can usually be assigned unambiguously by hand using only COSY and 13C-HMBC data, whereas condensed heterocycles are problematic due to their lack of protons that could show interatomic connectivities. Different computer programs were developed to aid in the structural assignment process, one of them COCON. In the case of unsaturated and substituted molecules structure generators frequently will generate a very large number of possible solutions. This article presents a "statistical filter" for the reduction of the number of results. The filter works by generating 3D conformations using smi23d, a simple MD approach. All molecules for which the generation of constitutional restraints failed were eliminated from the result set. Some structural elements removed by the statistical filter were analyzed and checked against Beilstein. The automatic removal of molecules for which no MD parameter set could be created was included into WEBCOCON. The effect of this filter varies in dependence of the NMR data set used, but in no case the correct constitution was removed from the resulting set. PMID:21835037

  14. Virus-based piezoelectric energy generation

    NASA Astrophysics Data System (ADS)

    Lee, Byung Yang; Zhang, Jinxing; Zueger, Chris; Chung, Woo-Jae; Yoo, So Young; Wang, Eddie; Meyer, Joel; Ramesh, Ramamoorthy; Lee, Seung-Wuk

    2012-06-01

    Piezoelectric materials can convert mechanical energy into electrical energy, and piezoelectric devices made of a variety of inorganic materials and organic polymers have been demonstrated. However, synthesizing such materials often requires toxic starting compounds, harsh conditions and/or complex procedures. Previously, it was shown that hierarchically organized natural materials such as bones, collagen fibrils and peptide nanotubes can display piezoelectric properties. Here, we demonstrate that the piezoelectric and liquid-crystalline properties of M13 bacteriophage (phage) can be used to generate electrical energy. Using piezoresponse force microscopy, we characterize the structure-dependent piezoelectric properties of the phage at the molecular level. We then show that self-assembled thin films of phage can exhibit piezoelectric strengths of up to 7.8 pm V-1. We also demonstrate that it is possible to modulate the dipole strength of the phage, hence tuning the piezoelectric response, by genetically engineering the major coat proteins of the phage. Finally, we develop a phage-based piezoelectric generator that produces up to 6 nA of current and 400 mV of potential and use it to operate a liquid-crystal display. Because biotechnology techniques enable large-scale production of genetically modified phages, phage-based piezoelectric materials potentially offer a simple and environmentally friendly approach to piezoelectric energy generation.

  15. A rainfall simulator based on multifractal generator

    NASA Astrophysics Data System (ADS)

    Akrour, Nawal; mallet, Cecile; barthes, Laurent; chazottes, Aymeric

    2015-04-01

    The Precipitations are due to complex meteorological phenomenon's and unlike other geophysical constituents such as water vapour concentration they present a relaxation behaviour leading to an alternation of dry and wet periods. Thus, precipitations can be described as intermittent process. The spatial and temporal variability of this phenomenon is significant and covers large scales. This high variability can cause extreme events which are difficult to observe properly because of their suddenness and their localized character. For all these reasons, the precipitations are therefore difficult to model. This study aims to adapt a one-dimensional time series model previously developed by the authors [Akrour et al., 2013, 2014] to a two-dimensional rainfall generator. The original time series model can be divided into 3 major steps : rain support generation, intra event rain rates generation using multifractal and finally calibration process. We use the same kind of methodology in the present study. Based on dataset obtained from meteorological radar of Météo France with a spatial resolution of 1 km x 1 km we present the used approach : Firstly, the extraction of rain support (rain/no rain area) allowing the retrieval of the rain support structure function (variogram) and fractal properties. This leads us to use either the rain support modelisation proposed by ScleissXXX [ref] or directly real rain support extracted from radar rain maps. Then, the generation (over rain areas) of rain rates is made thanks to a 2D multifractal Fractionnally Integrated Flux (FIF) model [ref]. This second stage is followed by a calibration/forcing step (forcing average rain rate per events) added in order to provide rain rate coherent with observed rain-rate distribution. The forcing process is based on a relation identified from the average rain rate of observed events and their surfaces. The presentation will first explain the different steps presented above, then some results

  16. A rule-based software test data generator

    NASA Technical Reports Server (NTRS)

    Deason, William H.; Brown, David B.; Chang, Kai-Hsiung; Cross, James H., II

    1991-01-01

    Rule-based software test data generation is proposed as an alternative to either path/predicate analysis or random data generation. A prototype rule-based test data generator for Ada programs is constructed and compared to a random test data generator. Four Ada procedures are used in the comparison. Approximately 2000 rule-based test cases and 100,000 randomly generated test cases are automatically generated and executed. The success of the two methods is compared using standard coverage metrics. Simple statistical tests showing that even the primitive rule-based test data generation prototype is significantly better than random data generation are performed. This result demonstrates that rule-based test data generation is feasible and shows great promise in assisting test engineers, especially when the rule base is developed further.

  17. Virus-based piezoelectric energy generator

    SciTech Connect

    2012-01-01

    Lawrence Berkeley National Laboratory scientists have developed a way to generate power using harmless viruses that convert mechanical energy into electricity. The milestone could lead to tiny devices that harvest electrical energy from the vibrations of everyday tasks. The first part of the video shows how Berkeley Lab scientists harness the piezoelectric properties of the virus to convert the force of a finger tap into electricity. The second part reveals the "viral-electric" generators in action, first by pressing only one of the generators, then by pressing two at the same time, which produces more current.

  18. Advanced Coal-Based Power Generations

    NASA Technical Reports Server (NTRS)

    Robson, F. L.

    1982-01-01

    Advanced power-generation systems using coal-derived fuels are evaluated in two-volume report. Report considers fuel cells, combined gas- and steam-turbine cycles, and magnetohydrodynamic (MHD) energy conversion. Presents technological status of each type of system and analyzes performance of each operating on medium-Btu fuel gas, either delivered via pipeline to powerplant or generated by coal-gasification process at plantsite.

  19. A magnetoelectric composite based signal generator

    NASA Astrophysics Data System (ADS)

    Fetisov, Y. K.; Serov, V. N.; Fetisov, L. Y.; Makovkin, S. A.; Viehland, D.; Srinivasan, G.

    2016-05-01

    Self-oscillations in an active loop consisting of a wide-band amplifier and a magnetoelectric composite in the feedback circuit have been observed. The composite with a ferroelectric lead zirconate titanate bimorph and ferromagnetic Metglas serves as a resonator that determines the frequency of oscillations and provides the feedback voltage. Under amplitude balance and phase matching conditions, the device generated signals at 2.3 kHz, at the bending resonance frequency of the composite. The oscillations were observed over a specific range of magnetic bias H. The shape of the signal generated is dependent on electrical circuit parameters and magnitude and orientation of H.

  20. Intra-generational Redistribution under Public Pension Planning Based on Generation-based Funding Scheme

    NASA Astrophysics Data System (ADS)

    Banjo, Daisuke; Tamura, Hiroyuki; Murata, Tadahiko

    In this paper, we propose a method of determining the pension in the generation-based funding scheme. In this proposal, we include two types of pensions in the scheme. One is the payment-amount related pension and the other is the payment-frequency related pension. We set the ratio of the total amount of payment-amount related pension to the total amount of both pensions, and simulate income gaps and the relationship between contributions and benefits for each individual when the proposed method is applied.

  1. Computer-Based Arithmetic Test Generation

    ERIC Educational Resources Information Center

    Trocchi, Robert F.

    1973-01-01

    The computer can be a welcome partner in the instructional process, but only if there is man-machine interaction. Man should not compromise system design because of available hardware; the computer must fit the system design for the result to represent an acceptable solution to instructional technology. The Arithmetic Test Generator system fits…

  2. Modeling Rule-Based Item Generation

    ERIC Educational Resources Information Center

    Geerlings, Hanneke; Glas, Cees A. W.; van der Linden, Wim J.

    2011-01-01

    An application of a hierarchical IRT model for items in families generated through the application of different combinations of design rules is discussed. Within the families, the items are assumed to differ only in surface features. The parameters of the model are estimated in a Bayesian framework, using a data-augmented Gibbs sampler. An obvious…

  3. Estimating evaporative vapor generation from automobiles based on parking activities.

    PubMed

    Dong, Xinyi; Tschantz, Michael; Fu, Joshua S

    2015-07-01

    A new approach is proposed to quantify the evaporative vapor generation based on real parking activity data. As compared to the existing methods, two improvements are applied in this new approach to reduce the uncertainties: First, evaporative vapor generation from diurnal parking events is usually calculated based on estimated average parking duration for the whole fleet, while in this study, vapor generation rate is calculated based on parking activities distribution. Second, rather than using the daily temperature gradient, this study uses hourly temperature observations to derive the hourly incremental vapor generation rates. The parking distribution and hourly incremental vapor generation rates are then adopted with Wade-Reddy's equation to estimate the weighted average evaporative generation. We find that hourly incremental rates can better describe the temporal variations of vapor generation, and the weighted vapor generation rate is 5-8% less than calculation without considering parking activity. PMID:25818089

  4. Next Generation Multimedia Distributed Data Base Systems

    NASA Technical Reports Server (NTRS)

    Pendleton, Stuart E.

    1997-01-01

    The paradigm of client/server computing is changing. The model of a server running a monolithic application and supporting clients at the desktop is giving way to a different model that blurs the line between client and server. We are on the verge of plunging into the next generation of computing technology--distributed object-oriented computing. This is not only a change in requirements but a change in opportunities, and requires a new way of thinking for Information System (IS) developers. The information system demands caused by global competition are requiring even more access to decision making tools. Simply, object-oriented technology has been developed to supersede the current design process of information systems which is not capable of handling next generation multimedia.

  5. Optimal Test Design with Rule-Based Item Generation

    ERIC Educational Resources Information Center

    Geerlings, Hanneke; van der Linden, Wim J.; Glas, Cees A. W.

    2013-01-01

    Optimal test-design methods are applied to rule-based item generation. Three different cases of automated test design are presented: (a) test assembly from a pool of pregenerated, calibrated items; (b) test generation on the fly from a pool of calibrated item families; and (c) test generation on the fly directly from calibrated features defining…

  6. Coal and Coal/Biomass-Based Power Generation

    EPA Science Inventory

    For Frank Princiotta's book, Global Climate Change--The Technology Challenge Coal is a key, growing component in power generation globally. It generates 50% of U.S. electricity, and criteria emissions from coal-based power generation are being reduced. However, CO2 emissions m...

  7. Meta-data based mediator generation

    SciTech Connect

    Critchlaw, T

    1998-06-28

    Mediators are a critical component of any data warehouse; they transform data from source formats to the warehouse representation while resolving semantic and syntactic conflicts. The close relationship between mediators and databases requires a mediator to be updated whenever an associated schema is modified. Failure to quickly perform these updates significantly reduces the reliability of the warehouse because queries do not have access to the most current data. This may result in incorrect or misleading responses, and reduce user confidence in the warehouse. Unfortunately, this maintenance may be a significant undertaking if a warehouse integrates several dynamic data sources. This paper describes a meta-data framework, and associated software, designed to automate a significant portion of the mediator generation task and thereby reduce the effort involved in adapting to schema changes. By allowing the DBA to concentrate on identifying the modifications at a high level, instead of reprogramming the mediator, turnaround time is reduced and warehouse reliability is improved.

  8. Ontodog: a web-based ontology community view generation tool.

    PubMed

    Zheng, Jie; Xiang, Zuoshuang; Stoeckert, Christian J; He, Yongqun

    2014-05-01

    Biomedical ontologies are often very large and complex. Only a subset of the ontology may be needed for a specified application or community. For ontology end users, it is desirable to have community-based labels rather than the labels generated by ontology developers. Ontodog is a web-based system that can generate an ontology subset based on Excel input, and support generation of an ontology community view, which is defined as the whole or a subset of the source ontology with user-specified annotations including user-preferred labels. Ontodog allows users to easily generate community views with minimal ontology knowledge and no programming skills or installation required. Currently >100 ontologies including all OBO Foundry ontologies are available to generate the views based on user needs. We demonstrate the application of Ontodog for the generation of community views using the Ontology for Biomedical Investigations as the source ontology. PMID:24413522

  9. Model Based Analysis and Test Generation for Flight Software

    NASA Technical Reports Server (NTRS)

    Pasareanu, Corina S.; Schumann, Johann M.; Mehlitz, Peter C.; Lowry, Mike R.; Karsai, Gabor; Nine, Harmon; Neema, Sandeep

    2009-01-01

    We describe a framework for model-based analysis and test case generation in the context of a heterogeneous model-based development paradigm that uses and combines Math- Works and UML 2.0 models and the associated code generation tools. This paradigm poses novel challenges to analysis and test case generation that, to the best of our knowledge, have not been addressed before. The framework is based on a common intermediate representation for different modeling formalisms and leverages and extends model checking and symbolic execution tools for model analysis and test case generation, respectively. We discuss the application of our framework to software models for a NASA flight mission.

  10. The Reliability of Randomly Generated Math Curriculum-Based Measurements

    ERIC Educational Resources Information Center

    Strait, Gerald G.; Smith, Bradley H.; Pender, Carolyn; Malone, Patrick S.; Roberts, Jarod; Hall, John D.

    2015-01-01

    "Curriculum-Based Measurement" (CBM) is a direct method of academic assessment used to screen and evaluate students' skills and monitor their responses to academic instruction and intervention. Interventioncentral.org offers a math worksheet generator at no cost that creates randomly generated "math curriculum-based measures"…

  11. Advanced gasification-based biomass power generation

    SciTech Connect

    Williams, R.H.; Larson, E.D.

    1993-12-31

    A promising strategy for modernizing bioenergy is the production of electricity or the cogeneration of electricity and heat using gasified biomass with advanced conversion technologies. Major advances that have been made in coal gasification technology, to marry the gas turbine to coal, are readily adaptable to biomass applications. Integrating biomass gasifiers with aeroderivative gas turbines in particular makes it possible to achieve high efficiencies and low unit capital costs at the modest scales required for bioenergy systems. Electricity produced with biomass-integrated gasifier/gas turbine (BIG/GT) power systems not only offers major environmental benefits but also would be competitive with electricity produced from fossil fuels and nuclear energy under a wide range of circumstances. Initial applications will be with biomass residues generated in the sugarcane, pulp and paper, and other agro- and forest-product industries. Eventually, biomass grown for energy purposes on dedicated energy farms will also be used to fuel these gas turbine systems. Continuing improvements in jet engine and biomass gasification technologies will lead to further gains in the performance of BIG/GT systems over the next couple of decades. Fuel cells operated on gasified biomass offer the promise of even higher performance levels in the period beyond the turn of the century. 79 refs., 21 figs., 11 tabs.

  12. Fiber based generation of azimuthally polarized light

    NASA Astrophysics Data System (ADS)

    Jocher, Christoph; Jauregui, Cesar; Voigtländer, Christian; Stutzki, Fabian; Nolte, Stefan; Limpert, Jens; Tünnermann, Andreas

    2012-02-01

    We report on a novel approach for the generation of radially and azimuthally polarized light employing a fiber mode filter. The mode filter consists of a Fiber Bragg Grating written in a strongly guiding fiber with lifted modal degeneracy. These kinds of fibers guide radially and azimuthally polarized modes with non-degenerated, i.e. distinct, effective refractive indexes. The Fiber Bragg Grating reflects light only if the Bragg condition is fulfilled. In case of strongly guiding fibers the radially and azimuthally polarized modes are guided with different effective refractive indices and, consequently, the Bragg condition is fulfilled at different wavelengths. If the reflection bandwidth of the Fiber Bragg Grating is narrow enough, the radially and azimuthally polarized modes are spectrally separated. Thus, with such a mode filter it is possible to filter the radially or azimuthally polarized mode. This filter is suitable for its integration in a resonator for stable, compact and high polarization purity azimuthally and radially polarized all-fiber oscillators. In a first experiment an azimuthally polarized mode filter consisting of a commercially available step index fiber and a femtosecond written Fiber Bragg Grating was fabricated. The experimental results are presented and discussed.

  13. Mechanically based generative laws of morphogenesis

    NASA Astrophysics Data System (ADS)

    Beloussov, Lev V.

    2008-03-01

    A deep (although at the first glance naïve) question which may be addressed to embryonic development is why during this process quite definite and accurately reproduced successions of precise and complicated shapes are taking place, or why, in several cases, the result of development is highly precise in spite of an extensive variability of intermediate stages. This problem can be attacked in two different ways. One of them, up to now just slightly employed, is to formulate robust macroscopic generative laws from which the observed successions of shapes could be derived. Another one, which dominates in modern embryology, regards the development as a succession of highly precise 'micropatterns', each of them arising due to the action of specific factors, having, as a rule, nothing in common with each other. We argue that the latter view contradicts a great bulk of firmly established data and gives no satisfactory answers to the main problems of development. Therefore we intend to follow the first way. By doing this, we regard developing embryos as self-organized systems transpierced by feedbacks among which we pay special attention to those linked with mechanical stresses (MS). We formulate a hypothesis of so-called MS hyper-restoration as a common basis for the developmentally important feedback loops. We present a number of examples confirming this hypothesis and use it for reconstructing prolonged chains of developmental events. Finally, we discuss the application of the same set of assumptions to the first steps of egg development and to the internal differentiation of embryonic cells.

  14. Evidence base in guideline generation in diabetes.

    PubMed

    Mühlhauser, I; Meyer, G

    2013-06-01

    During recent years much emphasis has been on the validity, reliability, reproducibility, clinical applicability, clarity, multidisciplinary process, scheduled review and documentation of clinical practice guidelines (CPGs). Still, CPGs show substantial variance in methodological quality. The present paper mainly focuses on two aspects that are particularly critical and contemporary from the perspective of evidence-based medicine: patient centredness and shared decision making, and conflict of interest. Sophisticated patient and consumer involvement at all stages of CPG development could be judged as being the gold standard. However, co-opting patients or consumer representatives and using other techniques of active patient involvement does not replace individual patient preferences in clinical decision-making processes. Current CPGs do not meet patient needs, since they do not provide concise, easy-to-read summaries of the benefits and risks of medicines together with more comprehensive scientific data as a prerequisite for informed or shared decision making. The vast majority of CPG panels have a financial conflict of interest (COI) and under-reporting is common. Not all organisations producing CPGs have set up COI policies, and existing policies vary widely. To solve the problem, CPG experts have recommended that methodologists without any important COI should lead the development process and have primary responsibility. There is a lot of room for other improvements through network transnational activities in the field of CPG development. Waste of time and resources should be avoided through sharing published and unpublished data identified, appraised and extracted for guideline development. The EASD could provide such a clearing house. PMID:23475367

  15. [Design of Electrocardiogram Signal Generator Based on Typical Electrocardiogram Database].

    PubMed

    Wang, Yuting; Wang, Xiaofei; Li, Dongshang; Liu, Guili

    2016-02-01

    Using LabVIEW programming and high-speed multifunction data acquisition card PCI-6251, we designed an electrocardiogram (ECG) signal generator based on Chinese typical ECG database. When the ECG signals are given off by the generator, the generator can also display the ECG information annotations at the same time, including waveform data and diagnostic results. It could be a useful assisting tool of ECG automatic diagnose instruments. PMID:27382747

  16. HOUDINI: a new approach to computer-based structure generation.

    PubMed

    Korytko, A; Schulz, K-P; Madison, M S; Munk, M E

    2003-01-01

    A new method of structure generation called convergent structure generation has been developed to address limitations of earlier methods. The features of the program (HOUDINI) based on this method include the following: a single integrated representation of the collective substructural information; the use of parallel atom groups for efficient processing of families of alternative substructural inferences; and a managed structure generation procedure designed to build required structural features early in the process. PMID:14502476

  17. Field-Based Concerns about Fourth-Generation Evaluation Theory.

    ERIC Educational Resources Information Center

    Lai, Morris K.

    Some aspects of fourth generation evaluation procedures that have been advocated by E. G. Guba and Y. S. Lincoln were examined empirically, with emphasis on areas where there have been discrepancies between theory and field-based experience. In fourth generation evaluation, the product of an evaluation is not a set of conclusions, recommendations,…

  18. The Hebrewer: A Web-Based Inflection Generator

    ERIC Educational Resources Information Center

    Foster, James Q.; Harrell, Lane Foster; Raizen, Esther

    2004-01-01

    This paper reports on the grammatical and programmatical production aspects of the "Hebrewer," a cross-platform web-based reference work in the form of a Hebrew inflection generator. The Hebrewer, a Java applet/servlet combination, is currently capable of generating 2,500 nouns in full declension and 500 verbs in full conjugation, displaying the…

  19. Preserving Differential Privacy in Degree-Correlation based Graph Generation

    PubMed Central

    Wang, Yue; Wu, Xintao

    2014-01-01

    Enabling accurate analysis of social network data while preserving differential privacy has been challenging since graph features such as cluster coefficient often have high sensitivity, which is different from traditional aggregate functions (e.g., count and sum) on tabular data. In this paper, we study the problem of enforcing edge differential privacy in graph generation. The idea is to enforce differential privacy on graph model parameters learned from the original network and then generate the graphs for releasing using the graph model with the private parameters. In particular, we develop a differential privacy preserving graph generator based on the dK-graph generation model. We first derive from the original graph various parameters (i.e., degree correlations) used in the dK-graph model, then enforce edge differential privacy on the learned parameters, and finally use the dK-graph model with the perturbed parameters to generate graphs. For the 2K-graph model, we enforce the edge differential privacy by calibrating noise based on the smooth sensitivity, rather than the global sensitivity. By doing this, we achieve the strict differential privacy guarantee with smaller magnitude noise. We conduct experiments on four real networks and compare the performance of our private dK-graph models with the stochastic Kronecker graph generation model in terms of utility and privacy tradeoff. Empirical evaluations show the developed private dK-graph generation models significantly outperform the approach based on the stochastic Kronecker generation model. PMID:24723987

  20. Method to implement the CCD timing generator based on FPGA

    NASA Astrophysics Data System (ADS)

    Li, Binhua; Song, Qian; He, Chun; Jin, Jianhui; He, Lin

    2010-07-01

    With the advance of the PFPA technology, the design methodology of digital systems is changing. In recent years we develop a method to implement the CCD timing generator based on FPGA and VHDL. This paper presents the principles and implementation skills of the method. Taking a developed camera as an example, we introduce the structure, input and output clocks/signals of a timing generator implemented in the camera. The generator is composed of a top module and a bottom module. The bottom one is made up of 4 sub-modules which correspond to 4 different operation modes. The modules are implemented by 5 VHDL programs. Frame charts of the architecture of these programs are shown in the paper. We also describe implementation steps of the timing generator in Quartus II, and the interconnections between the generator and a Nios soft core processor which is the controller of this generator. Some test results are presented in the end.

  1. Data Generators for Learning Systems Based on RBF Networks.

    PubMed

    Robnik-Sikonja, Marko

    2016-05-01

    There are plenty of problems where the data available is scarce and expensive. We propose a generator of semiartificial data with similar properties to the original data, which enables the development and testing of different data mining algorithms and the optimization of their parameters. The generated data allow large-scale experimentation and simulations without danger of overfitting. The proposed generator is based on radial basis function networks, which learn sets of Gaussian kernels. These Gaussian kernels can be used in a generative mode to generate new data from the same distributions. To assess the quality of the generated data, we evaluated the statistical properties of the generated data, structural similarity, and predictive similarity using supervised and unsupervised learning techniques. To determine usability of the proposed generator we conducted a large scale evaluation using 51 data sets. The results show a considerable similarity between the original and generated data and indicate that the method can be useful in several development and simulation scenarios. We analyze possible improvements in the classification performance by adding different amounts of the generated data to the training set, performance on high-dimensional data sets, and conditions when the proposed approach is successful. PMID:26011896

  2. Synchronous Generator Model Parameter Estimation Based on Noisy Dynamic Waveforms

    NASA Astrophysics Data System (ADS)

    Berhausen, Sebastian; Paszek, Stefan

    2016-01-01

    In recent years, there have occurred system failures in many power systems all over the world. They have resulted in a lack of power supply to a large number of recipients. To minimize the risk of occurrence of power failures, it is necessary to perform multivariate investigations, including simulations, of power system operating conditions. To conduct reliable simulations, the current base of parameters of the models of generating units, containing the models of synchronous generators, is necessary. In the paper, there is presented a method for parameter estimation of a synchronous generator nonlinear model based on the analysis of selected transient waveforms caused by introducing a disturbance (in the form of a pseudorandom signal) in the generator voltage regulation channel. The parameter estimation was performed by minimizing the objective function defined as a mean square error for deviations between the measurement waveforms and the waveforms calculated based on the generator mathematical model. A hybrid algorithm was used for the minimization of the objective function. In the paper, there is described a filter system used for filtering the noisy measurement waveforms. The calculation results of the model of a 44 kW synchronous generator installed on a laboratory stand of the Institute of Electrical Engineering and Computer Science of the Silesian University of Technology are also given. The presented estimation method can be successfully applied to parameter estimation of different models of high-power synchronous generators operating in a power system.

  3. Microwave filter based on Lamb modes for optoelectronic generator

    NASA Astrophysics Data System (ADS)

    Vitko, V. V.; Nikitin, A. A.; Kondrashov, A. V.; Nikitin, A. A.; Ustinov, A. B.; Belyavskiy, P. Yu; Kalinikos, B. A.; Butler, J. E.

    2015-12-01

    Experimental results for narrowband filter based on yttrium iron garnet film epitaxially grown on gadolinium gallium garnet substrate have been shown. The principle of operation of the filter is based on excitation of Lamb modes in the substrate. We demonstrated also that the use of single crystal diamond as a substrate will significantly reduce the phase noise of the designed optoelectronic microwave generator.

  4. Hydrogen-based power generation from bioethanol steam reforming

    NASA Astrophysics Data System (ADS)

    Tasnadi-Asztalos, Zs.; Cormos, C. C.; Agachi, P. S.

    2015-12-01

    This paper is evaluating two power generation concepts based on hydrogen produced from bioethanol steam reforming at industrial scale without and with carbon capture. The power generation from bioethanol conversion is based on two important steps: hydrogen production from bioethanol catalytic steam reforming and electricity generation using a hydrogen-fuelled gas turbine. As carbon capture method to be assessed in hydrogen-based power generation from bioethanol steam reforming, the gas-liquid absorption using methyl-di-ethanol-amine (MDEA) was used. Bioethanol is a renewable energy carrier mainly produced from biomass fermentation. Steam reforming of bioethanol (SRE) provides a promising method for hydrogen and power production from renewable resources. SRE is performed at high temperatures (e.g. 800-900°C) to reduce the reforming by-products (e.g. ethane, ethene). The power generation from hydrogen was done with M701G2 gas turbine (334 MW net power output). Hydrogen was obtained through catalytic steam reforming of bioethanol without and with carbon capture. For the evaluated plant concepts the following key performance indicators were assessed: fuel consumption, gross and net power outputs, net electrical efficiency, ancillary consumptions, carbon capture rate, specific CO2 emission etc. As the results show, the power generation based on bioethanol conversion has high energy efficiency and low carbon footprint.

  5. Hydrogen-based power generation from bioethanol steam reforming

    SciTech Connect

    Tasnadi-Asztalos, Zs. Cormos, C. C. Agachi, P. S.

    2015-12-23

    This paper is evaluating two power generation concepts based on hydrogen produced from bioethanol steam reforming at industrial scale without and with carbon capture. The power generation from bioethanol conversion is based on two important steps: hydrogen production from bioethanol catalytic steam reforming and electricity generation using a hydrogen-fuelled gas turbine. As carbon capture method to be assessed in hydrogen-based power generation from bioethanol steam reforming, the gas-liquid absorption using methyl-di-ethanol-amine (MDEA) was used. Bioethanol is a renewable energy carrier mainly produced from biomass fermentation. Steam reforming of bioethanol (SRE) provides a promising method for hydrogen and power production from renewable resources. SRE is performed at high temperatures (e.g. 800-900°C) to reduce the reforming by-products (e.g. ethane, ethene). The power generation from hydrogen was done with M701G2 gas turbine (334 MW net power output). Hydrogen was obtained through catalytic steam reforming of bioethanol without and with carbon capture. For the evaluated plant concepts the following key performance indicators were assessed: fuel consumption, gross and net power outputs, net electrical efficiency, ancillary consumptions, carbon capture rate, specific CO{sub 2} emission etc. As the results show, the power generation based on bioethanol conversion has high energy efficiency and low carbon footprint.

  6. The guitar chord-generating algorithm based on complex network

    NASA Astrophysics Data System (ADS)

    Ren, Tao; Wang, Yi-fan; Du, Dan; Liu, Miao-miao; Siddiqi, Awais

    2016-02-01

    This paper aims to generate chords for popular songs automatically based on complex network. Firstly, according to the characteristics of guitar tablature, six chord networks of popular songs by six pop singers are constructed and the properties of all networks are concluded. By analyzing the diverse chord networks, the accompaniment regulations and features are shown, with which the chords can be generated automatically. Secondly, in terms of the characteristics of popular songs, a two-tiered network containing a verse network and a chorus network is constructed. With this network, the verse and chorus can be composed respectively with the random walk algorithm. Thirdly, the musical motif is considered for generating chords, with which the bad chord progressions can be revised. This method can make the accompaniments sound more melodious. Finally, a popular song is chosen for generating chords and the new generated accompaniment sounds better than those done by the composers.

  7. Model based document and report generation for systems engineering

    NASA Astrophysics Data System (ADS)

    Delp, C.; Lam, D.; Fosse, E.; Lee, Cin-Young

    As Model Based Systems Engineering (MBSE) practices gain adoption, various approaches have been developed in order to simplify and automate the process of generating documents from models. Essentially, all of these techniques can be unified around the concept of producing different views of the model according to the needs of the intended audience. In this paper, we will describe a technique developed at JPL of applying SysML Viewpoints and Views to generate documents and reports. An architecture of model-based view and document generation will be presented, and the necessary extensions to SysML with associated rationale will be explained. A survey of examples will highlight a variety of views that can be generated, and will provide some insight into how collaboration and integration is enabled. We will also describe the basic architecture for the enterprise applications that support this approach.

  8. Model Based Document and Report Generation for Systems Engineering

    NASA Technical Reports Server (NTRS)

    Delp, Christopher; Lam, Doris; Fosse, Elyse; Lee, Cin-Young

    2013-01-01

    As Model Based Systems Engineering (MBSE) practices gain adoption, various approaches have been developed in order to simplify and automate the process of generating documents from models. Essentially, all of these techniques can be unified around the concept of producing different views of the model according to the needs of the intended audience. In this paper, we will describe a technique developed at JPL of applying SysML Viewpoints and Views to generate documents and reports. An architecture of model-based view and document generation will be presented, and the necessary extensions to SysML with associated rationale will be explained. A survey of examples will highlight a variety of views that can be generated, and will provide some insight into how collaboration and integration is enabled. We will also describe the basic architecture for the enterprise applications that support this approach.

  9. Cardiovascular and lung mesh generation based on centerlines.

    PubMed

    Marchandise, E; Geuzaine, C; Remacle, J F

    2013-06-01

    We present a fully automatic procedure for the mesh generation of tubular geometries such as blood vessels or airways. The procedure is implemented in the open-source Gmsh software and relies on a centerline description of the input geometry. The presented method can generate different type of meshes: isotropic tetrahedral meshes, anisotropic tetrahedral meshes, and mixed hexahedral/tetrahedral meshes. Additionally, a multiple layered arterial wall can be generated with a variable thickness. All the generated meshes rely on a mesh size field and a mesh metric that is based on centerline descriptions, namely the distance to the centerlines and a local reference system based on the tangent and the normal directions to the centerlines. Different examples show that the proposed method is very efficient and robust and leads to high quality computational meshes. PMID:23606344

  10. MEMS-Based Power Generation Techniques for Implantable Biosensing Applications

    PubMed Central

    Lueke, Jonathan; Moussa, Walied A.

    2011-01-01

    Implantable biosensing is attractive for both medical monitoring and diagnostic applications. It is possible to monitor phenomena such as physical loads on joints or implants, vital signs, or osseointegration in vivo and in real time. Microelectromechanical (MEMS)-based generation techniques can allow for the autonomous operation of implantable biosensors by generating electrical power to replace or supplement existing battery-based power systems. By supplementing existing battery-based power systems for implantable biosensors, the operational lifetime of the sensor is increased. In addition, the potential for a greater amount of available power allows additional components to be added to the biosensing module, such as computational and wireless and components, improving functionality and performance of the biosensor. Photovoltaic, thermovoltaic, micro fuel cell, electrostatic, electromagnetic, and piezoelectric based generation schemes are evaluated in this paper for applicability for implantable biosensing. MEMS-based generation techniques that harvest ambient energy, such as vibration, are much better suited for implantable biosensing applications than fuel-based approaches, producing up to milliwatts of electrical power. High power density MEMS-based approaches, such as piezoelectric and electromagnetic schemes, allow for supplemental and replacement power schemes for biosensing applications to improve device capabilities and performance. In addition, this may allow for the biosensor to be further miniaturized, reducing the need for relatively large batteries with respect to device size. This would cause the implanted biosensor to be less invasive, increasing the quality of care received by the patient. PMID:22319362

  11. First neutron generation in the BINP accelerator based neutron source.

    PubMed

    Bayanov, B; Burdakov, A; Chudaev, V; Ivanov, A; Konstantinov, S; Kuznetsov, A; Makarov, A; Malyshkin, G; Mekler, K; Sorokin, I; Sulyaev, Yu; Taskaev, S

    2009-07-01

    Pilot innovative facility for neutron capture therapy was built at Budker Institute of Nuclear Physics, Novosibirsk. This facility is based on a compact vacuum insulation tandem accelerator designed to produce proton current up to 10 mA. Epithermal neutrons are proposed to be generated by 1.915 MeV protons bombarding a lithium target using (7)Li(p,n)(7)Be threshold reaction. The results of the first experiments on neutron generation are reported and discussed. PMID:19375928

  12. Novel power saving architecture for FBG based OCDMA code generation

    NASA Astrophysics Data System (ADS)

    Osadola, Tolulope B.; Idris, Siti K.; Glesk, Ivan

    2013-10-01

    A novel architecture for generating incoherent, 2-dimensional wavelength hopping-time spreading optical CDMA codes is presented. The architecture is designed to facilitate the reuse of optical source signal that is unused after an OCDMA code has been generated using fiber Bragg grating based encoders. Effective utilization of available optical power is therefore achieved by cascading several OCDMA encoders thereby enabling 3dB savings in optical power.

  13. Osmosis-Based Pressure Generation: Dynamics and Application

    PubMed Central

    Li, Suyi; Billeh, Yazan N.; Wang, K. W.; Mayer, Michael

    2014-01-01

    This paper describes osmotically-driven pressure generation in a membrane-bound compartment while taking into account volume expansion, solute dilution, surface area to volume ratio, membrane hydraulic permeability, and changes in osmotic gradient, bulk modulus, and degree of membrane fouling. The emphasis lies on the dynamics of pressure generation; these dynamics have not previously been described in detail. Experimental results are compared to and supported by numerical simulations, which we make accessible as an open source tool. This approach reveals unintuitive results about the quantitative dependence of the speed of pressure generation on the relevant and interdependent parameters that will be encountered in most osmotically-driven pressure generators. For instance, restricting the volume expansion of a compartment allows it to generate its first 5 kPa of pressure seven times faster than without a restraint. In addition, this dynamics study shows that plants are near-ideal osmotic pressure generators, as they are composed of many small compartments with large surface area to volume ratios and strong cell wall reinforcements. Finally, we demonstrate two applications of an osmosis-based pressure generator: actuation of a soft robot and continuous volume delivery over long periods of time. Both applications do not need an external power source but rather take advantage of the energy released upon watering the pressure generators. PMID:24614529

  14. A computer-based tool for generation of progress notes.

    PubMed Central

    Campbell, K. E.; Wieckert, K.; Fagan, L. M.; Musen, M. A.

    1993-01-01

    IVORY, a computer-based tool that uses clinical findings as the basic unit for composing progress notes, generates progress notes more efficiently than does a character-based word processor. IVORY's clinical findings are contained within a structured vocabulary that we developed to support generation of both prose progress notes and SNOMED III codes. Observational studies of physician participation in the development of IVORY's structured vocabulary have helped us to identify areas where changes are required before IVORY will be acceptable for routine clinical use. PMID:8130479

  15. A Pseudo-Random Number Generator Based on Normal Numbers

    SciTech Connect

    Bailey, David H.

    2004-12-31

    In a recent paper, Richard Crandall and the present author established that each of a certain class of explicitly given real constants, uncountably infinite in number, is b-normal, for an integer that appears in the formula defining the constant. A b-normal constant is one where every string of m digits appears in the base-b expansion of the constant with limiting frequency b{sup -m}. This paper shows how this result can be used to fashion an efficient and effective pseudo-random number generator, which generates successive strings of binary digits from one of the constants in this class. The resulting generator, which tests slightly faster than a conventional linear congruential generator, avoids difficulties with large power-of-two data access strides that may occur when using conventional generators. It is also well suited for parallel processing--each processor can quickly and independently compute its starting value, with the collective sequence generated by all processors being the same as that generated by a single processor.

  16. 10. Interior view, east side of power plant, generator bases ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Interior view, east side of power plant, generator bases in foreground, electrical panels and fuel tanks in background looking northeast - Naval Air Station Fallon, Power Plant, 800 Complex, off Carson Road near intersection of Pasture & Berney Roads, Fallon, Churchill County, NV

  17. Space-based laser-driven MHD generator: Feasibility study

    NASA Technical Reports Server (NTRS)

    Choi, S. H.

    1986-01-01

    The feasibility of a laser-driven MHD generator, as a candidate receiver for a space-based laser power transmission system, was investigated. On the basis of reasonable parameters obtained in the literature, a model of the laser-driven MHD generator was developed with the assumptions of a steady, turbulent, two-dimensional flow. These assumptions were based on the continuous and steady generation of plasmas by the exposure of the continuous wave laser beam thus inducing a steady back pressure that enables the medium to flow steadily. The model considered here took the turbulent nature of plasmas into account in the two-dimensional geometry of the generator. For these conditions with the plasma parameters defining the thermal conductivity, viscosity, electrical conductivity for the plasma flow, a generator efficiency of 53.3% was calculated. If turbulent effects and nonequilibrium ionization are taken into account, the efficiency is 43.2%. The study shows that the laser-driven MHD system has potential as a laser power receiver for space applications because of its high energy conversion efficiency, high energy density and relatively simple mechanism as compared to other energy conversion cycles.

  18. An Evolution Based Biosensor Receptor DNA Sequence Generation Algorithm

    PubMed Central

    Kim, Eungyeong; Lee, Malrey; Gatton, Thomas M.; Lee, Jaewan; Zang, Yupeng

    2010-01-01

    A biosensor is composed of a bioreceptor, an associated recognition molecule, and a signal transducer that can selectively detect target substances for analysis. DNA based biosensors utilize receptor molecules that allow hybridization with the target analyte. However, most DNA biosensor research uses oligonucleotides as the target analytes and does not address the potential problems of real samples. The identification of recognition molecules suitable for real target analyte samples is an important step towards further development of DNA biosensors. This study examines the characteristics of DNA used as bioreceptors and proposes a hybrid evolution-based DNA sequence generating algorithm, based on DNA computing, to identify suitable DNA bioreceptor recognition molecules for stable hybridization with real target substances. The Traveling Salesman Problem (TSP) approach is applied in the proposed algorithm to evaluate the safety and fitness of the generated DNA sequences. This approach improves efficiency and stability for enhanced and variable-length DNA sequence generation and allows extension to generation of variable-length DNA sequences with diverse receptor recognition requirements. PMID:22315543

  19. All-optical pseudorandom bit sequences generator based on TOADs

    NASA Astrophysics Data System (ADS)

    Sun, Zhenchao; Wang, Zhi; Wu, Chongqing; Wang, Fu; Li, Qiang

    2016-03-01

    A scheme for all-optical pseudorandom bit sequences (PRBS) generator is demonstrated with optical logic gate 'XNOR' and all-optical wavelength converter based on cascaded Tera-Hertz Optical Asymmetric Demultiplexer (TOADs). Its feasibility is verified by generation of return-to-zero on-off keying (RZ-OOK) 263-1 PRBS at the speed of 1 Gb/s with 10% duty radio. The high randomness of ultra-long cycle PRBS is validated by successfully passing the standard benchmark test.

  20. A 212Pb generator based on a 228Th source.

    PubMed

    Hassfjell, S

    2001-10-01

    A two-compartment 212Pb generator has been constructed and characterized physically and chemically. It is based on transport by airflow of gaseous 220Rn emanating from thin layers of [228Th]barium stearate. 220Rn is collected in a glass bubbler by extraction into an organic solvent and solidified at temperatures below -72 degrees C. Tracer studies show that the decay product 212Pb can be recovered with approximately 70% yield. It is suggested that this generator design could accommodate therapeutic levels of 212Pb/228Th. PMID:11545493

  1. Image analysis techniques associated with automatic data base generation.

    NASA Technical Reports Server (NTRS)

    Bond, A. D.; Ramapriyan, H. K.; Atkinson, R. J.; Hodges, B. C.; Thomas, D. T.

    1973-01-01

    This paper considers some basic problems relating to automatic data base generation from imagery, the primary emphasis being on fast and efficient automatic extraction of relevant pictorial information. Among the techniques discussed are recursive implementations of some particular types of filters which are much faster than FFT implementations, a 'sequential similarity detection' technique of implementing matched filters, and sequential linear classification of multispectral imagery. Several applications of the above techniques are presented including enhancement of underwater, aerial and radiographic imagery, detection and reconstruction of particular types of features in images, automatic picture registration and classification of multiband aerial photographs to generate thematic land use maps.

  2. Quantum random number generator based on photonic emission in semiconductors.

    PubMed

    Stipcević, M; Rogina, B Medved

    2007-04-01

    We report upon the realization of a novel fast nondeterministic random number generator whose randomness relies on the intrinsic randomness of the quantum physical processes of photonic emission in semiconductors and subsequent detection by the photoelectric effect. Timing information of detected photons is used to generate binary random digits-bits. The bit extraction method based on the restartable clock method theoretically eliminates both bias and autocorrelation while reaching efficiency of almost 0.5 bits per random event. A prototype has been built and statistically tested. PMID:17477690

  3. Porous cobalt-based thin film as a bifunctional catalyst for hydrogen generation and oxygen generation.

    PubMed

    Yang, Yang; Fei, Huilong; Ruan, Gedeng; Tour, James M

    2015-05-27

    A mixed-phased Co-based catalyst composed of Co phosphide and Co phosphate is successfully fabricated for bifunctional water electrolysis. The highly porous morphology in this anodized film enables efficient catalytic activity toward water splitting in an extremely low loading mass. The mixed phases in the porous film afford an ability to generate both H2 and O2 in a single electrolyzer. PMID:25872881

  4. Realistic facial animation generation based on facial expression mapping

    NASA Astrophysics Data System (ADS)

    Yu, Hui; Garrod, Oliver; Jack, Rachael; Schyns, Philippe

    2014-01-01

    Facial expressions reflect internal emotional states of a character or in response to social communications. Though much effort has been taken to generate realistic facial expressions, it still remains a challenging topic due to human being's sensitivity to subtle facial movements. In this paper, we present a method for facial animation generation, which reflects true facial muscle movements with high fidelity. An intermediate model space is introduced to transfer captured static AU peak frames based on FACS to the conformed target face. And then dynamic parameters derived using a psychophysics method is integrated to generate facial animation, which is assumed to represent natural correlation of multiple AUs. Finally, the animation sequence in the intermediate model space is mapped to the target face to produce final animation.

  5. Fully photonics-based physical random bit generator.

    PubMed

    Li, Pu; Sun, Yuanyuan; Liu, Xianglian; Yi, Xiaogang; Zhang, Jianguo; Guo, Xiaomin; Guo, Yanqiang; Wang, Yuncai

    2016-07-15

    We propose a fully photonics-based approach for ultrafast physical random bit generation. This approach exploits a compact nonlinear loop mirror (called a terahertz optical asymmetric demultiplexer, TOAD) to sample the chaotic optical waveform in an all-optical domain and then generate random bit streams through further comparison with a threshold level. This method can efficiently overcome the electronic jitter bottleneck confronted by existing RBGs in practice. A proof-of-concept experiment demonstrates that this method can continuously extract 5 Gb/s random bit streams from the chaotic output of a distributed feedback laser diode (DFB-LD) with optical feedback. This limited generation rate is caused by the bandwidth of the used optical chaos. PMID:27420532

  6. New negative resist design with novel photo-base generator

    NASA Astrophysics Data System (ADS)

    Wang, Wen-Yun; Wu, Cheng Han; Su, Yu-Chang; Wu, Chen-Hao; Chang, Ya-Hui; Chang, Ching-Yu; Ku, Yao-Ching

    2013-03-01

    An alternate negative tone resist is investigated for advanced lithography. Unlike conventional negative tone development (NTD) resists developed with organic solvent, this negative resist use TMAH as its developer. Thermal acid generator (TAG) and photo base generator (PBG) are proposed for this resist. PBG decomposes and generates alkali at the exposed area and neutralizes the acid from TAG. Hence, positive resist can produce negative tone image (NTI), and gain better optical contrast than positive tone imaging. The new negative resist reported in this paper also shows better resolution than conventional negative resist. Several optimization studies are also reported. In addition, major limitations on further improving resist resolution are also pointed out in this paper. The solution proposed has been proven workable from experimental results. This opens the possibility to combine better optical contrast from NTI, high resist resolution from positive resist resin, and better development contrast from TMAH solution.

  7. Homopolar artificial gravity generator based on frame-dragging

    NASA Astrophysics Data System (ADS)

    Tajmar, M.

    2010-05-01

    Space exploration is linked in many ways to the generation and challenges of artificial gravity. Space stations and drag-free satellite platforms are used to provide microgravity environments for scientific experiments. On the other hand, microgravity or reduced gravity environments such as on Moon and Mars are known to put limits for long-term human presence. Large centrifuges in space may provide Earth-like gravity environments during long-term travels, however, such technology certainly has its limits to provide similar environments for human outposts on other moons and planets. One can imagine a different technology using a prediction out of Einstein's general relativity theory which is called frame-dragging. In principle, frame-dragging might be used to generate artificial gravitational fields similar to electric fields generated by time-varying or moving magnetic fields. We will show that it is also possible to generate constant artificial gravitational fields that could provide microgravity or artificial gravity environments. Although such technology is possible in principle, the field strengths calculated from Einstein's theory are too small to be useful so far. However, recently detected anomalies around low-temperature spinning matter as well as fly-by anomalies point to possible enhancement mechanisms that might make an artificial gravity generator based on frame-dragging a reality in the future.

  8. Generation of diversity in a reaction-diffusion-based controller.

    PubMed

    Zahadat, Payam; Schmickl, Thomas

    2014-01-01

    A controller of biological or artificial organism (e.g., in bio-inspired cellular robots) consists of a number of processes that drive its dynamics. For a system of processes to perform as a successful controller, different properties can be mentioned. One of the desirable properties of such a system is the capability of generating sufficiently diverse patterns of outputs and behaviors. A system with such a capability is potentially adaptable to perform complicated tasks with proper parameterizations and may successfully reach the solution space of behaviors from the point of view of search and evolutionary algorithms. This article aims to take an early step toward exploring this capability at the levels of individuals and populations by introducing measures of diversity generation and by evaluating the influence of different types of processes on diversity generation. A reaction-diffusion-based controller called the artificial homeostatic hormone system (AHHS) is studied as a system consisting of different processes with various domains of functioning (e.g., internal or external to the control unit). Various combinations of these processes are investigated in terms of diversity generation at levels of both individuals and populations, and the effects of the processes are discussed representing different influences for the processes. A case study of evolving a multimodular AHHS controller with all the various process combinations is also investigated, representing the relevance of the diversity generation measures and practical scenarios. PMID:24730765

  9. A Third-Generation Evidence Base for Human Spaceflight Risks

    NASA Technical Reports Server (NTRS)

    Kundrot, Craig E.; Lumpkins, Sarah; Steil, Jennifer; Pellis, Neal; Charles, John

    2014-01-01

    NASA's Human Research Program seeks to understand and mitigate risks to crew health and performance in exploration missions center dot HRP's evidence base consists of an Evidence Report for each HRP risk center dot Three generations of Evidence Reports 1) Review articles + Good content - Limited authorship, infrequent updates 2) Wikipedia articles + Viewed often, very open to contributions - Summary of reviews, very few contributions 3) HRP-controlled wiki articles + Incremental additions to review articles with editorial control

  10. Control System for a Diesel Generator and UPS Based Microgrid

    NASA Astrophysics Data System (ADS)

    Palamar, Andriy; Pettai, Elmo; Beldjajev, Viktor

    2010-01-01

    In this paper a microgrid composed of a diesel generator and two uninterruptible power supply systems with separate battery banks is introduced. The microgrid located in three academic buildings of Tallinn University of Technology. A three-level control and monitoring system for the microgrid based on the EtherNet/IP communication network is developed. In addition, a control strategy of the microgrid in the grid-connected and stand-alone mode of operation is proposed.

  11. Spin-torque generation in topological insulator based heterostructures

    NASA Astrophysics Data System (ADS)

    Fischer, Mark H.; Vaezi, Abolhassan; Manchon, Aurelien; Kim, Eun-Ah

    2016-03-01

    Heterostructures utilizing topological insulators exhibit a remarkable spin-torque efficiency. However, the exact origin of the strong torque, in particular whether it stems from the spin-momentum locking of the topological surface states or rather from spin-Hall physics of the topological-insulator bulk, remains unclear. Here, we explore a mechanism of spin-torque generation purely based on the topological surface states. We consider topological-insulator-based bilayers involving ferromagnetic metal (TI/FM) and magnetically doped topological insulators (TI/mdTI), respectively. By ascribing the key theoretical differences between the two setups to location and number of active surface states, we describe both setups within the same framework of spin diffusion of the nonequilibrium spin density of the topological surface states. For the TI/FM bilayer, we find large spin-torque efficiencies of roughly equal magnitude for both in-plane and out-of-plane spin torques. For the TI/mdTI bilayer, we elucidate the dominance of the spin-transfer-like torque. However, we cannot explain the orders of magnitude enhancement reported. Nevertheless, our model gives an intuitive picture of spin-torque generation in topological-insulator-based bilayers and provides theoretical constraints on spin-torque generation due to topological surface states.

  12. An artificially generated atmosphere near a lunar base

    NASA Technical Reports Server (NTRS)

    Burns, Jack O.; Fernini, Ilias; Sulkanen, Martin; Duric, Nebojsa; Taylor, G. Jeffrey; Johnson, Stewart W.

    1992-01-01

    We discuss the formation of an artificial atmosphere generated by vigorous lunar base activity in this paper. We developed an analytical, steady-state model for a lunar atmosphere based upon previous investigations of the Moon's atmosphere from Apollo. Constant gas-injection rates, ballistic trajectories, and a Maxwellian particle distribution for an oxygen-like gas are assumed. Even for the extreme case of continuous He-3 mining of the lunar regolith, we find that the lunar atmosphere would not significantly degrade astronomical observations beyond about 10 km from the mining operation.

  13. Red beam generation based on aperiodically poled lithium niobate

    NASA Astrophysics Data System (ADS)

    Figen, Ziya Gürkan; Akın, Onur

    2014-04-01

    We propose a novel device with a simple architecture for high-power red beam generation. The device is an optical parametric generator based on an aperiodically poled LiNbO3 grating in which both the optical parametric amplification and sum frequency generation processes are simultaneously phase matched. The pump is a quasi-continuous-wave laser operating at 1064 nm. Aperiodic gratings which enable simultaneous phase matching of the two processes were designed using a method that gives the flexibility to adjust the relative strength of these two processes. A model that takes the diffraction of the beams into account was developed to characterize the red beam generation performance of the device depending on the parameters: the relative strength of these processes, the length of the crystal, the average pump power, and the pump beam waist radius. If one uses the 2-D Fourier transform in the solution of the coupled-mode equations, the computation power required for performing such a characterization on a personal computer is prohibitively large. Owing to the circular symmetry of the system, we employ the Hankel transform to overcome this bottleneck.

  14. One-to-one encapsulation based on alternating droplet generation

    NASA Astrophysics Data System (ADS)

    Hirama, Hirotada; Torii, Toru

    2015-10-01

    This paper reports the preparation of encapsulated particles as models of cells using an alternating droplet generation encapsulation method in which the number of particles in a droplet is controlled by a microchannel to achieve one-to-one encapsulation. Using a microchannel in which wettability is treated locally, the fluorescent particles used as models of cells were successfully encapsulated in uniform water-in-oil-in-water (W/O/W) emulsion droplets. Furthermore, 20% of the particle-containing droplets contained one particle. Additionally, when a surfactant with the appropriate properties was used, the fluorescent particles within each inner aqueous droplet were enclosed in the merged droplet by spontaneous droplet coalescence. This one-to-one encapsulation method based on alternating droplet generation could be used for a variety of applications, such as high-throughput single-cell assays, gene transfection into cells or one-to-one cell fusion.

  15. An Infrastructure for UML-Based Code Generation Tools

    NASA Astrophysics Data System (ADS)

    Wehrmeister, Marco A.; Freitas, Edison P.; Pereira, Carlos E.

    The use of Model-Driven Engineering (MDE) techniques in the domain of distributed embedded real-time systems are gain importance in order to cope with the increasing design complexity of such systems. This paper discusses an infrastructure created to build GenERTiCA, a flexible tool that supports a MDE approach, which uses aspect-oriented concepts to handle non-functional requirements from embedded and real-time systems domain. GenERTiCA generates source code from UML models, and also performs weaving of aspects, which have been specified within the UML model. Additionally, this paper discusses the Distributed Embedded Real-Time Compact Specification (DERCS), a PIM created to support UML-based code generation tools. Some heuristics to transform UML models into DERCS, which have been implemented in GenERTiCA, are also discussed.

  16. One-to-one encapsulation based on alternating droplet generation

    PubMed Central

    Hirama, Hirotada; Torii, Toru

    2015-01-01

    This paper reports the preparation of encapsulated particles as models of cells using an alternating droplet generation encapsulation method in which the number of particles in a droplet is controlled by a microchannel to achieve one-to-one encapsulation. Using a microchannel in which wettability is treated locally, the fluorescent particles used as models of cells were successfully encapsulated in uniform water-in-oil-in-water (W/O/W) emulsion droplets. Furthermore, 20% of the particle-containing droplets contained one particle. Additionally, when a surfactant with the appropriate properties was used, the fluorescent particles within each inner aqueous droplet were enclosed in the merged droplet by spontaneous droplet coalescence. This one-to-one encapsulation method based on alternating droplet generation could be used for a variety of applications, such as high-throughput single-cell assays, gene transfection into cells or one-to-one cell fusion. PMID:26487193

  17. Skin image reconstruction using Monte Carlo based color generation

    NASA Astrophysics Data System (ADS)

    Aizu, Yoshihisa; Maeda, Takaaki; Kuwahara, Tomohiro; Hirao, Tetsuji

    2010-11-01

    We propose a novel method of skin image reconstruction based on color generation using Monte Carlo simulation of spectral reflectance in the nine-layered skin tissue model. The RGB image and spectral reflectance of human skin are obtained by RGB camera and spectrophotometer, respectively. The skin image is separated into the color component and texture component. The measured spectral reflectance is used to evaluate scattering and absorption coefficients in each of the nine layers which are necessary for Monte Carlo simulation. Various skin colors are generated by Monte Carlo simulation of spectral reflectance in given conditions for the nine-layered skin tissue model. The new color component is synthesized to the original texture component to reconstruct the skin image. The method is promising for applications in the fields of dermatology and cosmetics.

  18. Second-generation photosensitizers based on natural chlorines and bacteriochlorines

    NASA Astrophysics Data System (ADS)

    Mironov, Andrei F.

    1996-01-01

    New sensitizers for photodynamic therapy were synthesized on the base of biologically generated chlorins and bacteriochlorins. Derivatives of chlorophyll a and bacteriochlorophyll were prepared from the biomass of blue-green algae Spirulina Platensis and purple bacteria Rhodobacter Capsulatus, generated using specially designed photobioreactor. The strategy for chemical transformation of natural chlorophylls and bacteriochlorophyll has been discussed. Purpurin 18 and its dihydroanalogue bacteriopurpurin were chosen as the key intermediates. Modifications of peripheral substituents, such as introducing the new functional groups, hydrogenation of the B-pyrrolic ring, and insertion of amino acid residues gave the series of novel sensitizers, including water soluble chlorin p6 analogues, and derivatives with graded amphiphility for the studies of tumor accumulation in the malignant tissues.

  19. Ultrafast quantum random number generation based on quantum phase fluctuations.

    PubMed

    Xu, Feihu; Qi, Bing; Ma, Xiongfeng; Xu, He; Zheng, Haoxuan; Lo, Hoi-Kwong

    2012-05-21

    A quantum random number generator (QRNG) can generate true randomness by exploiting the fundamental indeterminism of quantum mechanics. Most approaches to QRNG employ single-photon detection technologies and are limited in speed. Here, we experimentally demonstrate an ultrafast QRNG at a rate over 6 Gbits/s based on the quantum phase fluctuations of a laser operating near threshold. Moreover, we consider a potential adversary who has partial knowledge on the raw data and discuss how one can rigorously remove such partial knowledge with postprocessing. We quantify the quantum randomness through min-entropy by modeling our system and employ two randomness extractors--Trevisan's extractor and Toeplitz-hashing--to distill the randomness, which is information-theoretically provable. The simplicity and high-speed of our experimental setup show the feasibility of a robust, low-cost, high-speed QRNG. PMID:22714224

  20. Surface skeleton generation based on 360-degree profile scan

    NASA Astrophysics Data System (ADS)

    Chen, Lujie; Sass, Lawrence; Sung, Woong Ki; Noel, Vernelle

    2013-05-01

    A rapid prototyping method is invented, which works on a specific data structure produced by an optical metrology technique: 360-degree surface profile scanning. A computer algorithm takes an object profile data, restructure the format, generate horizontal and vertical ribs, lay out the ribs on a 2D canvas and output the geometries to a file format compatible with laser cutters. A laser cutting machine is subsequently used to cut all the ribs from sheet materials. Then, the ribs are manually assembled based on computer-generated assembly codes. Through this process, the original object's 3D surface can be prototyped rapidly at an arbitrary scale, which may well exceed the working dimension of the laser cutter.

  1. Assessment of disk MHD generators for a base load powerplant

    NASA Technical Reports Server (NTRS)

    Chubb, D. L.; Retallick, F. D.; Lu, C. L.; Stella, M.; Teare, J. D.; Loubsky, W. J.; Louis, J. F.; Misra, B.

    1981-01-01

    Results from a study of the disk MHD generator are presented. Both open and closed cycle disk systems were investigated. Costing of the open cycle disk components (nozzle, channel, diffuser, radiant boiler, magnet and power management) was done. However, no detailed costing was done for the closed cycle systems. Preliminary plant design for the open cycle systems was also completed. Based on the system study results, an economic assessment of the open cycle systems is presented. Costs of the open cycle disk conponents are less than comparable linear generator components. Also, costs of electricity for the open cycle disk systems are competitive with comparable linear systems. Advantages of the disk design simplicity are considered. Improvements in the channel availability or a reduction in the channel lifetime requirement are possible as a result of the disk design.

  2. Model-based automatic generation of grasping regions

    NASA Technical Reports Server (NTRS)

    Bloss, David A.

    1993-01-01

    The problem of automatically generating stable regions for a robotic end effector on a target object, given a model of the end effector and the object is discussed. In order to generate grasping regions, an initial valid grasp transformation from the end effector to the object is obtained based on form closure requirements, and appropriate rotational and translational symmetries are associated with that transformation in order to construct a valid, continuous grasping region. The main result of this algorithm is a list of specific, valid grasp transformations of the end effector to the target object, and the appropriate combinations of translational and rotational symmetries associated with each specific transformation in order to produce a continuous grasp region.

  3. Optimization of Gear Ratio in the Tidal Current Generation System based on Generated Energy

    NASA Astrophysics Data System (ADS)

    Naoi, Kazuhisa; Shiono, Mitsuhiro; Suzuki, Katsuyuki

    It is possible to predict generating power of the tidal current generation, because of the tidal current's periodicity. Tidal current generation is more advantageous than other renewable energy sources, when the tidal current generation system is connected to the power system and operated. In this paper, we propose a method used to optimize the gear ratio and generator capacity, that is fundamental design items in the tidal current generation system which is composed of Darrieus type water turbine and squirrel-cage induction generator coupled with gear. The proposed method is applied to the tidal current generation system including the most large-sized turbine that we have developed and studied. This paper shows optimum gear ratio and generator capacity that make generated energy maximum, and verify effectiveness of the proposed method. The paper also proposes a method of selecting maximum generating current velocity in order to reduce the generator capacity, from the viewpoint of economics.

  4. Quality-based generation of weather radar Cartesian products

    NASA Astrophysics Data System (ADS)

    Osrodka, K.; Szturc, J.

    2015-05-01

    Weather radar data volumes are commonly processed to obtain various 2-D Cartesian products based on the transfer from polar to Cartesian representations through a certain interpolation method. In this research an algorithm of the spatial interpolation of polar reflectivity data employing quality index data is applied to find the Cartesian reflectivity as plan position indicator products. On this basis, quality-based versions of standard algorithms for the generation of the following products have been developed: ETOP (echo top), MAX (maximum of reflectivity), and VIL (vertically integrated liquid water). Moreover, as an example of a higher-level product, a CONVECTION (detection of convection) has been defined as a specific combination of the above-listed standard products. A corresponding quality field is determined for each generated product, taking into account the quality of the pixels from which a given product was determined and how large a fraction of the investigated heights was scanned. Examples of such quality-based products are presented in the paper.

  5. [Generation of a synthetic seismic data base]. Final report

    SciTech Connect

    Aldrich, C.H. III

    1995-10-22

    A consortium (Los Alamos, Sandia, OR, Livermore) have been collaborating under the GONII project to generate a synthetic seismic data base. Two deliverables were a common code that would run on the various site machines, and the use of these codes to generate parts of the final data base. The data base consists of a large number of shots applied to two geographic models developed by another part of GONII, the salt model and the overthrust model,s which were supplied as large files containing propagation velocity on a 3-D grid. Los Alamos was supplied with the source code of a seismic propagation code written by the French Petroleum Institute. A decision was made to port a subset of the code to Fortran on a node. Part of this contract was spent verifying/debugging the Fortran on a node code; a port of the code was made to run on the Cray. A total of 846 shots were run on the CM5. It was found that files on the SDA are not safe from corruption and the model velocity file may change.

  6. Optimization Research of Generation Investment Based on Linear Programming Model

    NASA Astrophysics Data System (ADS)

    Wu, Juan; Ge, Xueqian

    Linear programming is an important branch of operational research and it is a mathematical method to assist the people to carry out scientific management. GAMS is an advanced simulation and optimization modeling language and it will combine a large number of complex mathematical programming, such as linear programming LP, nonlinear programming NLP, MIP and other mixed-integer programming with the system simulation. In this paper, based on the linear programming model, the optimized investment decision-making of generation is simulated and analyzed. At last, the optimal installed capacity of power plants and the final total cost are got, which provides the rational decision-making basis for optimized investments.

  7. Digitally based pattern generator for an electron-beam welder

    SciTech Connect

    Whitten, L.G. III

    1981-02-19

    A digitally based deflection generator for an electron-beam welder is presented. Up to seven patterns of any shape are stored in programmable read-only memory (PROM). The pattern resolution is 39% at frequencies from 10 Hz to 1 kHz and can be x-t, y-t, or x-y formed. Frequency and pattern selections may be chosen by the welder computer or manually selected on the front panel. The ability to repeatedly synchronize two waveforms of any shape and frequency enables an unlimited variety of welds.

  8. Stokes vector formalism based second harmonic generation microscopy

    NASA Astrophysics Data System (ADS)

    Qiu, Jianjun; Mazumder, Nirmal; Tsai, Han-Ruei; Hu, Chih-Wei; Kao, Fu-Jen

    2012-02-01

    In this study, we have developed a four-channel Stokes vector formalism based second harmonic generation (SHG) microscopy to map and analyze SHG signal. A four-channel Stokesmeter setup is calibrated and integrated into a laser scanning microscope to measure and characterize the SH's corresponding Stokes parameters. We are demonstrating the use of SH and its Stokes parameters to visualize the birefringence and crystalline orientation of KDP and collagen. We believe the developed method can reveal unprecedented information for biomedical and biomaterial studies.

  9. Membrane-based processes for sustainable power generation using water.

    PubMed

    Logan, Bruce E; Elimelech, Menachem

    2012-08-16

    Water has always been crucial to combustion and hydroelectric processes, but it could become the source of power in membrane-based systems that capture energy from natural and waste waters. Two processes are emerging as sustainable methods for capturing energy from sea water: pressure-retarded osmosis and reverse electrodialysis. These processes can also capture energy from waste heat by generating artificial salinity gradients using synthetic solutions, such as thermolytic salts. A further source of energy comes from organic matter in waste waters, which can be harnessed using microbial fuel-cell technology, allowing both wastewater treatment and power production. PMID:22895336

  10. High harmonic generation by novel fiber amplifier based sources.

    PubMed

    Hädrich, S; Rothhardt, J; Krebs, M; Tavella, F; Willner, A; Limpert, J; Tünnermann, A

    2010-09-13

    Significant progress in high repetition rate ultrashort pulse sources based on fiber technology is presented. These systems enable operation at a high repetition rate of up to 500 kHz and high average power in the extreme ultraviolet wavelength range via high harmonic generation in a gas jet. High average power few-cycle pulses of a fiber amplifier pumped optical parametric chirped pulse amplifier are used to produce µW level average power for the strongest harmonic at 42.9 nm at a repetition rate of 96 kHz. PMID:20940915

  11. Incorporating Feature-Based Annotations into Automatically Generated Knowledge Representations

    NASA Astrophysics Data System (ADS)

    Lumb, L. I.; Lederman, J. I.; Aldridge, K. D.

    2006-12-01

    Earth Science Markup Language (ESML) is efficient and effective in representing scientific data in an XML- based formalism. However, features of the data being represented are not accounted for in ESML. Such features might derive from events (e.g., a gap in data collection due to instrument servicing), identifications (e.g., a scientifically interesting area/volume in an image), or some other source. In order to account for features in an ESML context, we consider them from the perspective of annotation, i.e., the addition of information to existing documents without changing the originals. Although it is possible to extend ESML to incorporate feature-based annotations internally (e.g., by extending the XML schema for ESML), there are a number of complicating factors that we identify. Rather than pursuing the ESML-extension approach, we focus on an external representation for feature-based annotations via XML Pointer Language (XPointer). In previous work (Lumb &Aldridge, HPCS 2006, IEEE, doi:10.1109/HPCS.2006.26), we have shown that it is possible to extract relationships from ESML-based representations, and capture the results in the Resource Description Format (RDF). Thus we explore and report on this same requirement for XPointer-based annotations of ESML representations. As in our past efforts, the Global Geodynamics Project (GGP) allows us to illustrate with a real-world example this approach for introducing annotations into automatically generated knowledge representations.

  12. Fault Diagnosis Strategies for SOFC-Based Power Generation Plants.

    PubMed

    Costamagna, Paola; De Giorgi, Andrea; Gotelli, Alberto; Magistri, Loredana; Moser, Gabriele; Sciaccaluga, Emanuele; Trucco, Andrea

    2016-01-01

    The success of distributed power generation by plants based on solid oxide fuel cells (SOFCs) is hindered by reliability problems that can be mitigated through an effective fault detection and isolation (FDI) system. However, the numerous operating conditions under which such plants can operate and the random size of the possible faults make identifying damaged plant components starting from the physical variables measured in the plant very difficult. In this context, we assess two classical FDI strategies (model-based with fault signature matrix and data-driven with statistical classification) and the combination of them. For this assessment, a quantitative model of the SOFC-based plant, which is able to simulate regular and faulty conditions, is used. Moreover, a hybrid approach based on the random forest (RF) classification method is introduced to address the discrimination of regular and faulty situations due to its practical advantages. Working with a common dataset, the FDI performances obtained using the aforementioned strategies, with different sets of monitored variables, are observed and compared. We conclude that the hybrid FDI strategy, realized by combining a model-based scheme with a statistical classifier, outperforms the other strategies. In addition, the inclusion of two physical variables that should be measured inside the SOFCs can significantly improve the FDI performance, despite the actual difficulty in performing such measurements. PMID:27556472

  13. Graphene-Based Photocatalysts for Solar-Fuel Generation.

    PubMed

    Xiang, Quanjun; Cheng, Bei; Yu, Jiaguo

    2015-09-21

    The production of solar fuel through photocatalytic water splitting and CO2 reduction using photocatalysts has attracted considerable attention owing to the global energy shortage and growing environmental problems. During the past few years, many studies have demonstrated that graphene can markedly enhance the efficiency of photocatalysts for solar-fuel generation because of its unique 2D conjugated structure and electronic properties. Herein we summarize the recent advances in the application of graphene-based photocatalysts for solar-fuel production, including CO2 reduction to hydrocarbon fuel and water splitting to H2. A brief overview of the fundamental principles for splitting of water and reduction of CO2 is given. The different roles of graphene in these graphene-based photocatalysts for improving photocatalytic performance are discussed. Finally, the perspectives on the challenges and opportunities for future research in this promising area are also presented. PMID:26079429

  14. Copula-Based Approach to Synthetic Population Generation

    PubMed Central

    Kim, Deok-Soo

    2016-01-01

    Generating synthetic baseline populations is a fundamental step of agent-based modeling and simulation, which is growing fast in a wide range of socio-economic areas including transportation planning research. Traditionally, in many commercial and non-commercial microsimulation systems, the iterative proportional fitting (IPF) procedure has been used for creating the joint distribution of individuals when combining a reference joint distribution with target marginal distributions. Although IPF is simple, computationally efficient, and rigorously founded, it is unclear whether IPF well preserves the dependence structure of the reference joint table sufficiently when fitting it to target margins. In this paper, a novel method is proposed based on the copula concept in order to provide an alternative approach to the problem that IPF resolves. The dependency characteristic measures were computed and the results from the proposed method and IPF were compared. In most test cases, the proposed method outperformed IPF in preserving the dependence structure of the reference joint distribution. PMID:27490692

  15. Copula-Based Approach to Synthetic Population Generation.

    PubMed

    Jeong, Byungduk; Lee, Wonjoon; Kim, Deok-Soo; Shin, Hayong

    2016-01-01

    Generating synthetic baseline populations is a fundamental step of agent-based modeling and simulation, which is growing fast in a wide range of socio-economic areas including transportation planning research. Traditionally, in many commercial and non-commercial microsimulation systems, the iterative proportional fitting (IPF) procedure has been used for creating the joint distribution of individuals when combining a reference joint distribution with target marginal distributions. Although IPF is simple, computationally efficient, and rigorously founded, it is unclear whether IPF well preserves the dependence structure of the reference joint table sufficiently when fitting it to target margins. In this paper, a novel method is proposed based on the copula concept in order to provide an alternative approach to the problem that IPF resolves. The dependency characteristic measures were computed and the results from the proposed method and IPF were compared. In most test cases, the proposed method outperformed IPF in preserving the dependence structure of the reference joint distribution. PMID:27490692

  16. Knowledge-based zonal grid generation for computational fluid dynamics

    NASA Technical Reports Server (NTRS)

    Andrews, Alison E.

    1988-01-01

    Automation of flow field zoning in two dimensions is an important step towards reducing the difficulty of three-dimensional grid generation in computational fluid dynamics. Using a knowledge-based approach makes sense, but problems arise which are caused by aspects of zoning involving perception, lack of expert consensus, and design processes. These obstacles are overcome by means of a simple shape and configuration language, a tunable zoning archetype, and a method of assembling plans from selected, predefined subplans. A demonstration system for knowledge-based two-dimensional flow field zoning has been successfully implemented and tested on representative aerodynamic configurations. The results show that this approach can produce flow field zonings that are acceptable to experts with differing evaluation criteria.

  17. Pipelining flat CORDIC-based trigonometric function generators

    NASA Astrophysics Data System (ADS)

    Srikanthan, Thambipillai; Gisuthan, Bimal

    2000-10-01

    The significant advances in VLSI technology provided the impetus for porting algorithms into architectures. The CORDIC algorithm reigned supreme in this regard due to its canny ability to decimate trigonometric and hyperbolic functions with simple shift and add operations. Despite further refinements of the algorithm with the introduction of redundant arithmetic and higher radix CORDIC techniques, in terms of circuit latency and performance, the iterative nature remains to be the major bottleneck for further optimization. Although several techniques have been prosed to minimize this drawback, a technique known as flat CORDIC aims to eliminate it completely. In flat CORDIC, the conventional X and Y recurrences are successively substituted to express the final vectors in terms of the initial paper, the techniques devised for the VLSI efficient implementation of a 16-bit flat CORDIC based sine-cosine generator are presented. Three schemes for pipelining the 16-bit flat CORDIC design for high throughput solutions have been discussed. The 16-bit architecture has been synthesized using 0.35(mu) CMOS process library. Finally, a detailed comparison with other major contributions show that the flat CORDIC based size-cosine generators are, on an average, 30 percent faster with a significant 30 percent saving in silicon area.

  18. Ring Counter Based ATPG for Low Transition Test Pattern Generation

    PubMed Central

    Begam, V. M. Thoulath; Baulkani, S.

    2015-01-01

    In test mode test patterns are applied in random fashion to the circuit under circuit. This increases switching transition between the consecutive test patterns and thereby increases dynamic power dissipation. The proposed ring counter based ATPG reduces vertical switching transitions by inserting test vectors only between the less correlative test patterns. This paper presents the RC-ATPG with an external circuit. The external circuit consists of XOR gates, full adders, and multiplexers. First the total number of transitions between the consecutive test patterns is determined. If it is more, then the external circuit generates and inserts test vectors in between the two test patterns. Test vector insertion increases the correlation between the test patterns and reduces dynamic power dissipation. The results prove that the test patterns generated by the proposed ATPG have fewer transitions than the conventional ATPG. Experimental results based on ISCAS'85 and ISCAS'89 benchmark circuits show 38.5% reduction in the average power and 50% reduction in the peak power attained during testing with a small size decoding logic. PMID:26075295

  19. Feature based volume decomposition for automatic hexahedral mesh generation

    SciTech Connect

    LU,YONG; GADH,RAJIT; TAUTGES,TIMOTHY J.

    2000-02-21

    Much progress has been made through these years to achieve automatic hexahedral mesh generation. While general meshing algorithms that can take on general geometry are not there yet; many well-proven automatic meshing algorithms now work on certain classes of geometry. This paper presents a feature based volume decomposition approach for automatic Hexahedral Mesh generation. In this approach, feature recognition techniques are introduced to determine decomposition features from a CAD model. The features are then decomposed and mapped with appropriate automatic meshing algorithms suitable for the correspondent geometry. Thus a formerly unmeshable CAD model may become meshable. The procedure of feature decomposition is recursive: sub-models are further decomposed until either they are matched with appropriate meshing algorithms or no more decomposition features are detected. The feature recognition methods employed are convexity based and use topology and geometry information, which is generally available in BREP solid models. The operations of volume decomposition are also detailed in the paper. The final section, the capability of the feature decomposer is demonstrated over some complicated manufactured parts.

  20. PCA-LBG-based algorithms for VQ codebook generation

    NASA Astrophysics Data System (ADS)

    Tsai, Jinn-Tsong; Yang, Po-Yuan

    2015-04-01

    Vector quantisation (VQ) codebooks are generated by combining principal component analysis (PCA) algorithms with Linde-Buzo-Gray (LBG) algorithms. All training vectors are grouped according to the projected values of the principal components. The PCA-LBG-based algorithms include (1) PCA-LBG-Median, which selects the median vector of each group, (2) PCA-LBG-Centroid, which adopts the centroid vector of each group, and (3) PCA-LBG-Random, which randomly selects a vector of each group. The LBG algorithm finds a codebook based on the better vectors sent to an initial codebook by the PCA. The PCA performs an orthogonal transformation to convert a set of potentially correlated variables into a set of variables that are not linearly correlated. Because the orthogonal transformation efficiently distinguishes test image vectors, the proposed PCA-LBG-based algorithm is expected to outperform conventional algorithms in designing VQ codebooks. The experimental results confirm that the proposed PCA-LBG-based algorithms indeed obtain better results compared to existing methods reported in the literature.

  1. GENNY: A Knowledge-Based Text Generation System.

    ERIC Educational Resources Information Center

    Maybury, Mark T.

    1989-01-01

    Describes a computational model of the human process of generating text. The system design and generation process are discussed with particular attention to domain independence and cross language portability. The results of system tests are presented, the generator is evaluated with respect to current generators, and future directions are…

  2. FPGA Implementation of Metastability-Based True Random Number Generator

    NASA Astrophysics Data System (ADS)

    Hata, Hisashi; Ichikawa, Shuichi

    True random number generators (TRNGs) are important as a basis for computer security. Though there are some TRNGs composed of analog circuit, the use of digital circuits is desired for the application of TRNGs to logic LSIs. Some of the digital TRNGs utilize jitter in free-running ring oscillators as a source of entropy, which consume large power. Another type of TRNG exploits the metastability of a latch to generate entropy. Although this kind of TRNG has been mostly implemented with full-custom LSI technology, this study presents an implementation based on common FPGA technology. Our TRNG is comprised of logic gates only, and can be integrated in any kind of logic LSI. The RS latch in our TRNG is implemented as a hard-macro to guarantee the quality of randomness by minimizing the signal skew and load imbalance of internal nodes. To improve the quality and throughput, the output of 64-256 latches are XOR'ed. The derived design was verified on a Xilinx Virtex-4 FPGA (XC4VFX20), and passed NIST statistical test suite without post-processing. Our TRNG with 256 latches occupies 580 slices, while achieving 12.5Mbps throughput.

  3. Acoustically-driven thread-based tuneable gradient generators.

    PubMed

    Ramesan, Shwathy; Rezk, Amgad R; Cheng, Kai Wei; Chan, Peggy P Y; Yeo, Leslie Y

    2016-08-01

    Thread-based microfluidics offer a simple, easy to use, low-cost, disposable and biodegradable alternative to conventional microfluidic systems. While it has recently been shown that such thread networks facilitate manipulation of fluid samples including mixing, flow splitting and the formation of concentration gradients, the passive capillary transport of fluid through the thread does not allow for precise control due to the random orientation of cellulose fibres that make up the thread, nor does it permit dynamic manipulation of the flow. Here, we demonstrate the use of high frequency sound waves driven from a chip-scale device that drives rapid, precise and uniform convective transport through the thread network. In particular, we show that it is not only possible to generate a stable and continuous concentration gradient in a serial dilution and recombination network, but also one that can be dynamically tuned, which cannot be achieved solely with passive capillary transport. Additionally, we show a proof-of-concept in which such spatiotemporal gradient generation can be achieved with the entire thread network embedded in a three-dimensional hydrogel construct to more closely mimic the in vivo tissue microenvironment in microfluidic chemotaxis studies and cell culture systems, which is then employed to demonstrate the effect of such gradients on the proliferation of cells within the hydrogel. PMID:27334420

  4. Generation of a Fibrin Based Three-Layered Skin Substitute.

    PubMed

    Kober, Johanna; Gugerell, Alfred; Schmid, Melanie; Kamolz, Lars-Peter; Keck, Maike

    2015-01-01

    A variety of skin substitutes that restore epidermal and dermal structures are currently available on the market. However, the main focus in research and clinical application lies on dermal and epidermal substitutes whereas the development of a subcutaneous replacement (hypodermis) is often disregarded. In this study we used fibrin sealant as hydrogel scaffold to generate a three-layered skin substitute. For the hypodermal layer adipose-derived stem cells (ASCs) and mature adipocytes were embedded in the fibrin hydrogel and were combined with another fibrin clot with fibroblasts for the construction of the dermal layer. Keratinocytes were added on top of the two-layered construct to form the epidermal layer. The three-layered construct was cultivated for up to 3 weeks. Our results show that ASCs and fibroblasts were viable, proliferated normally, and showed physiological morphology in the skin substitute. ASCs were able to differentiate into mature adipocytes during the course of four weeks and showed morphological resemblance to native adipose tissue. On the surface keratinocytes formed an epithelial-like layer. For the first time we were able to generate a three-layered skin substitute based on a fibrin hydrogel not only serving as a dermal and epidermal substitute but also including the hypodermis. PMID:26236715

  5. Durable pd-based alloy and hydrogen generation membrane thereof

    DOEpatents

    Benn, Raymond C.; Opalka, Susanne M.; Vanderspurt, Thomas Henry

    2010-02-02

    A durable Pd-based alloy is used for a H.sub.2-selective membrane in a hydrogen generator, as in the fuel processor of a fuel cell plant. The Pd-based alloy includes Cu as a binary element, and further includes "X", where "X" comprises at least one metal from group "M" that is BCC and acts to stabilize the .beta. BCC phase for stability during operating temperatures. The metal from group "M" is selected from the group consisting of Fe, Cr, Nb, Ta, V, Mo, and W, with Nb and Ta being most preferred. "X" may further comprise at least one metal from a group "N" that is non-BCC, preferably FCC, that enhances other properties of the membrane, such as ductility. The metal from group "N" is selected from the group consisting of Ag, Au, Re, Ru, Rh, Y, Ce, Ni, Ir, Pt, Co, La and In. The at. % of Pd in the binary Pd--Cu alloy ranges from about 35 at. % to about 55 at. %, and the at. % of "X" in the higher order alloy, based on said binary alloy, is in the range of about 1 at. % to about 15 at. %. The metals are selected according to a novel process.

  6. MEDELLER: homology-based coordinate generation for membrane proteins

    PubMed Central

    Kelm, Sebastian; Shi, Jiye; Deane, Charlotte M.

    2010-01-01

    Motivation: Membrane proteins (MPs) are important drug targets but knowledge of their exact structure is limited to relatively few examples. Existing homology-based structure prediction methods are designed for globular, water-soluble proteins. However, we are now beginning to have enough MP structures to justify the development of a homology-based approach specifically for them. Results: We present a MP-specific homology-based coordinate generation method, MEDELLER, which is optimized to build highly reliable core models. The method outperforms the popular structure prediction programme Modeller on MPs. The comparison of the two methods was performed on 616 target–template pairs of MPs, which were classified into four test sets by their sequence identity. Across all targets, MEDELLER gave an average backbone root mean square deviation (RMSD) of 2.62 Å versus 3.16 Å for Modeller. On our ‘easy’ test set, MEDELLER achieves an average accuracy of 0.93 Å backbone RMSD versus 1.56 Å for Modeller. Availability and Implementation: http://medeller.info; Implemented in Python, Bash and Perl CGI for use on Linux systems; Supplementary data are available at http://www.stats.ox.ac.uk/proteins/resources. Contact: kelm@stats.ox.ac.uk Supplementary information: Supplementary data are available at Bioinformatics online. PMID:20926421

  7. Web-based Toolkit for Dynamic Generation of Data Processors

    NASA Astrophysics Data System (ADS)

    Patel, J.; Dascalu, S.; Harris, F. C.; Benedict, K. K.; Gollberg, G.; Sheneman, L.

    2011-12-01

    All computation-intensive scientific research uses structured datasets, including hydrology and all other types of climate-related research. When it comes to testing their hypotheses, researchers might use the same dataset differently, and modify, transform, or convert it to meet their research needs. Currently, many researchers spend a good amount of time performing data processing and building tools to speed up this process. They might routinely repeat the same process activities for new research projects, spending precious time that otherwise could be dedicated to analyzing and interpreting the data. Numerous tools are available to run tests on prepared datasets and many of them work with datasets in different formats. However, there is still a significant need for applications that can comprehensively handle data transformation and conversion activities and help prepare the various processed datasets required by the researchers. We propose a web-based application (a software toolkit) that dynamically generates data processors capable of performing data conversions, transformations, and customizations based on user-defined mappings and selections. As a first step, the proposed solution allows the users to define various data structures and, in the next step, can select various file formats and data conversions for their datasets of interest. In a simple scenario, the core of the proposed web-based toolkit allows the users to define direct mappings between input and output data structures. The toolkit will also support defining complex mappings involving the use of pre-defined sets of mathematical, statistical, date/time, and text manipulation functions. Furthermore, the users will be allowed to define logical cases for input data filtering and sampling. At the end of the process, the toolkit is designed to generate reusable source code and executable binary files for download and use by the scientists. The application is also designed to store all data

  8. Nanopore-based Fourth-generation DNA Sequencing Technology

    PubMed Central

    Feng, Yanxiao; Zhang, Yuechuan; Ying, Cuifeng; Wang, Deqiang; Du, Chunlei

    2015-01-01

    Nanopore-based sequencers, as the fourth-generation DNA sequencing technology, have the potential to quickly and reliably sequence the entire human genome for less than $1000, and possibly for even less than $100. The single-molecule techniques used by this technology allow us to further study the interaction between DNA and protein, as well as between protein and protein. Nanopore analysis opens a new door to molecular biology investigation at the single-molecule scale. In this article, we have reviewed academic achievements in nanopore technology from the past as well as the latest advances, including both biological and solid-state nanopores, and discussed their recent and potential applications. PMID:25743089

  9. Nanopore-based fourth-generation DNA sequencing technology.

    PubMed

    Feng, Yanxiao; Zhang, Yuechuan; Ying, Cuifeng; Wang, Deqiang; Du, Chunlei

    2015-02-01

    Nanopore-based sequencers, as the fourth-generation DNA sequencing technology, have the potential to quickly and reliably sequence the entire human genome for less than $1000, and possibly for even less than $100. The single-molecule techniques used by this technology allow us to further study the interaction between DNA and protein, as well as between protein and protein. Nanopore analysis opens a new door to molecular biology investigation at the single-molecule scale. In this article, we have reviewed academic achievements in nanopore technology from the past as well as the latest advances, including both biological and solid-state nanopores, and discussed their recent and potential applications. PMID:25743089

  10. Spike Detection Based on Normalized Correlation with Automatic Template Generation

    PubMed Central

    Hwang, Wen-Jyi; Wang, Szu-Huai; Hsu, Ya-Tzu

    2014-01-01

    A novel feedback-based spike detection algorithm for noisy spike trains is presented in this paper. It uses the information extracted from the results of spike classification for the enhancement of spike detection. The algorithm performs template matching for spike detection by a normalized correlator. The detected spikes are then sorted by the OSortalgorithm. The mean of spikes of each cluster produced by the OSort algorithm is used as the template of the normalized correlator for subsequent detection. The automatic generation and updating of templates enhance the robustness of the spike detection to input trains with various spike waveforms and noise levels. Experimental results show that the proposed algorithm operating in conjunction with OSort is an efficient design for attaining high detection and classification accuracy for spike sorting. PMID:24960082

  11. Managing Wind-based Electricity Generation and Storage

    NASA Astrophysics Data System (ADS)

    Zhou, Yangfang

    Among the many issues that profoundly affect the world economy every day, energy is one of the most prominent. Countries such as the U.S. strive to reduce reliance on the import of fossil fuels, and to meet increasing electricity demand without harming the environment. Two of the most promising solutions for the energy issue are to rely on renewable energy, and to develop efficient electricity storage. Renewable energy---such as wind energy and solar energy---is free, abundant, and most importantly, does not exacerbate the global warming problem. However, most renewable energy is inherently intermittent and variable, and thus can benefit greatly from coupling with electricity storage, such as grid-level industrial batteries. Grid storage can also help match the supply and demand of an entire electricity market. In addition, electricity storage such as car batteries can help reduce dependence on oil, as it can enable the development of Plug-in Hybrid Electric Vehicles, and Battery Electric Vehicles. This thesis focuses on understanding how to manage renewable energy and electricity storage properly together, and electricity storage alone. In Chapter 2, I study how to manage renewable energy, specifically wind energy. Managing wind energy is conceptually straightforward: generate and sell as much electricity as possible when prices are positive, and do nothing otherwise. However, this leads to curtailment when wind energy exceeds the transmission capacity, and possible revenue dilution when current prices are low but are expected to increase in the future. Electricity storage is being considered as a means to alleviate these problems, and also enables buying electricity from the market for later resale. But the presence of storage complicates the management of electricity generation from wind, and the value of storage for a wind-based generator is not entirely understood. I demonstrate that for such a combined generation and storage system the optimal policy does not

  12. Research of second harmonic generation images based on texture analysis

    NASA Astrophysics Data System (ADS)

    Liu, Yao; Li, Yan; Gong, Haiming; Zhu, Xiaoqin; Huang, Zufang; Chen, Guannan

    2014-09-01

    Texture analysis plays a crucial role in identifying objects or regions of interest in an image. It has been applied to a variety of medical image processing, ranging from the detection of disease and the segmentation of specific anatomical structures, to differentiation between healthy and pathological tissues. Second harmonic generation (SHG) microscopy as a potential noninvasive tool for imaging biological tissues has been widely used in medicine, with reduced phototoxicity and photobleaching. In this paper, we clarified the principles of texture analysis including statistical, transform, structural and model-based methods and gave examples of its applications, reviewing studies of the technique. Moreover, we tried to apply texture analysis to the SHG images for the differentiation of human skin scar tissues. Texture analysis method based on local binary pattern (LBP) and wavelet transform was used to extract texture features of SHG images from collagen in normal and abnormal scars, and then the scar SHG images were classified into normal or abnormal ones. Compared with other texture analysis methods with respect to the receiver operating characteristic analysis, LBP combined with wavelet transform was demonstrated to achieve higher accuracy. It can provide a new way for clinical diagnosis of scar types. At last, future development of texture analysis in SHG images were discussed.

  13. LISP based simulation generators for modeling complex space processes

    NASA Technical Reports Server (NTRS)

    Tseng, Fan T.; Schroer, Bernard J.; Dwan, Wen-Shing

    1987-01-01

    The development of a simulation assistant for modeling discrete event processes is presented. Included are an overview of the system, a description of the simulation generators, and a sample process generated using the simulation assistant.

  14. Generation of optical vortex based on computer-generated holographic gratings by photolithography

    NASA Astrophysics Data System (ADS)

    Li, Shaoxiang; Wang, Zhenwei

    2013-09-01

    The Laguerre-Gaussian beam is a typical example of the optical vortices, which can be generated by computer-generated holograms (CGHs) with the topological charge controlled. Here, we fabricated transmission-amplitude CGH gratings (up to 100 lines per millimeter) on metal film by photolithography technique. Such CGH grating grooves feature high resolution and fine smoothness, so that the gratings can be used to generate Laguerre-Gaussian beam with perfect mode. They are also applicable for the generation of femtosecond optical vortices due to the high damage threshold of the metal film.

  15. Modeling and control of fuel cell based distributed generation systems

    NASA Astrophysics Data System (ADS)

    Jung, Jin Woo

    This dissertation presents circuit models and control algorithms of fuel cell based distributed generation systems (DGS) for two DGS topologies. In the first topology, each DGS unit utilizes a battery in parallel to the fuel cell in a standalone AC power plant and a grid-interconnection. In the second topology, a Z-source converter, which employs both the L and C passive components and shoot-through zero vectors instead of the conventional DC/DC boost power converter in order to step up the DC-link voltage, is adopted for a standalone AC power supply. In Topology 1, two applications are studied: a standalone power generation (Single DGS Unit and Two DGS Units) and a grid-interconnection. First, dynamic model of the fuel cell is given based on electrochemical process. Second, two full-bridge DC to DC converters are adopted and their controllers are designed: an unidirectional full-bridge DC to DC boost converter for the fuel cell and a bidirectional full-bridge DC to DC buck/boost converter for the battery. Third, for a three-phase DC to AC inverter without or with a Delta/Y transformer, a discrete-time state space circuit model is given and two discrete-time feedback controllers are designed: voltage controller in the outer loop and current controller in the inner loop. And last, for load sharing of two DGS units and power flow control of two DGS units or the DGS connected to the grid, real and reactive power controllers are proposed. Particularly, for the grid-connected DGS application, a synchronization issue between an islanding mode and a paralleling mode to the grid is investigated, and two case studies are performed. To demonstrate the proposed circuit models and control strategies, simulation test-beds using Matlab/Simulink are constructed for each configuration of the fuel cell based DGS with a three-phase AC 120 V (L-N)/60 Hz/50 kVA and various simulation results are presented. In Topology 2, this dissertation presents system modeling, modified space

  16. Multiple Exciton Generation in Semiconductor Nanostructures: DFT-based Computation

    NASA Astrophysics Data System (ADS)

    Mihaylov, Deyan; Kryjevski, Andrei; Kilin, Dmitri; Kilina, Svetlana; Vogel, Dayton

    Multiple exciton generation (MEG) in nm-sized H-passivated Si nanowires (NWs), and quasi 2D nanofilms depends strongly on the degree of the core structural disorder as shown by the perturbation theory calculations based on the DFT simulations. In perturbation theory, we work to the 2nd order in the electron-photon coupling and in the (approximate) RPA-screened Coulomb interaction. We also include the effect of excitons for which we solve Bethe-Salpeter Equation. To describe MEG we calculate exciton-to-biexciton as well as biexciton-to-exciton rates and quantum efficiency (QE). We consider 3D arrays of Si29H36 quantum dots, NWs, and quasi 2D silicon nanofilms, all with both crystalline and amorphous core structures. Efficient MEG with QE of 1.3 up to 1.8 at the photon energy of about 3Egap is predicted in these nanoparticles except for the crystalline NW and film where QE ~=1. MEG in the amorphous nanoparticles is enhanced by the electron localization due to structural disorder. The exciton effects significantly red-shift QE vs. photon energy curves. Nm-sized a-Si NWs and films are predicted to have effective MEG within the solar spectrum range. Also, we find efficient MEG in the chiral single-wall Carbon nanotubes and in a perovskite nanostructure.

  17. Fiber-based generator for wearable electronics and mobile medication.

    PubMed

    Zhong, Junwen; Zhang, Yan; Zhong, Qize; Hu, Qiyi; Hu, Bin; Wang, Zhong Lin; Zhou, Jun

    2014-06-24

    Smart garments for monitoring physiological and biomechanical signals of the human body are key sensors for personalized healthcare. However, they typically require bulky battery packs or have to be plugged into an electric plug in order to operate. Thus, a smart shirt that can extract energy from human body motions to run body-worn healthcare sensors is particularly desirable. Here, we demonstrated a metal-free fiber-based generator (FBG) via a simple, cost-effective method by using commodity cotton threads, a polytetrafluoroethylene aqueous suspension, and carbon nanotubes as source materials. The FBGs can convert biomechanical motions/vibration energy into electricity utilizing the electrostatic effect with an average output power density of ∼0.1 μW/cm(2) and have been identified as an effective building element for a power shirt to trigger a wireless body temperature sensor system. Furthermore, the FBG was demonstrated as a self-powered active sensor to quantitatively detect human motion. PMID:24766072

  18. A Research on the Generative Learning Model Supported by Context-Based Learning

    ERIC Educational Resources Information Center

    Ulusoy, Fatma Merve; Onen, Aysem Seda

    2014-01-01

    This study is based on the generative learning model which involves context-based learning. Using the generative learning model, we taught the topic of Halogens. This topic is covered in the grade 10 chemistry curriculum using activities which are designed in accordance with the generative learning model supported by context-based learning. The…

  19. Generations.

    PubMed

    Chambers, David W

    2005-01-01

    Groups naturally promote their strengths and prefer values and rules that give them an identity and an advantage. This shows up as generational tensions across cohorts who share common experiences, including common elders. Dramatic cultural events in America since 1925 can help create an understanding of the differing value structures of the Silents, the Boomers, Gen Xers, and the Millennials. Differences in how these generations see motivation and values, fundamental reality, relations with others, and work are presented, as are some applications of these differences to the dental profession. PMID:16623137

  20. Self-organizing Symbol Acquisition and Motion Generation based on Dynamics-based Information Processing System

    NASA Astrophysics Data System (ADS)

    Okada, Masafumi; Nakamura, Daisuke; Nakamura, Yoshihiko

    The symbol acquisition and manipulation abilities are one of the inherent characteristics of human beings comparing with other creatures. In this paper, based on recurrent self-organizing map and dynamics-based information processing system, we propose a dynamics based self-organizing map (DBSOM). This method enables designing a topological map using time sequence data, which causes recognition and generation of the robot motion. Using this method, we design the self-organizing symbol acquisition system and robot motion generation system for a humanoid robot. By implementing DBSOM to the robot in the real world, we realize the symbol acquisition from the experimental data and investigate the spatial property of the obtained DBSOM.

  1. A tandem-based compact dual-energy gamma generator

    SciTech Connect

    Persaud, A.; Kwan, J.W.; Leitner, M.; Leung, K.N.; Ludewigt, B.; Tanaka, N.; Waldron, W.; Wilde, S.; Antolak, A.J.; Morse, D.H.; Raber, T.

    2009-11-11

    A dual-energy tandem-type gamma generator has been developed at E.O. Lawrence Berkeley National Laboratory and Sandia National Laboratories. The tandem accelerator geometry allows higher energy nuclear reactions to be reached, thereby allowing more flexible generation of MeV-energy gammas for active interrogation applications.

  2. Amplified CWDM-based Next Generation Broadband Access Networks

    NASA Astrophysics Data System (ADS)

    Peiris, Sasanthi Chamarika

    The explosive growth of both fixed and mobile data-centric traffic along with the inevitable trend towards all-IP/Ethernet transport protocols and packet switched networks will ultimately lead to an all-packet-based converged fixed-mobile optical transport network from the core all the way out to the access network. To address the increasing capacity and speed requirements in the access networks, Wavelength-Division Multiplexed (WDM) and/or Coarse WDM (CWDM)-based Passive Optical Networks (PONs) are expected to emerge as the next-generation optical access infrastructures. However, due to several techno-economic hurdles, CWDM-PONs are still considered an expensive solution and have not yet made any significant inroads into the current access area. One of the key technology hurdles is the scalability of the CWDM-based PONs. Passive component optical insertion losses limit the reach of the network or the number of served optical network units (ONUs). In the recent years, optical amplified CWDM approaches have emerged and new designs of optical amplifiers have been proposed and demonstrated. The critical design parameter for these amplifiers is the very wide optical amplification bandwidth (e.g., 340 nm combined for both directions). The objective of this PhD dissertation work is first to engineer ring and tree-ring based PON architectures that can achieve longer unamplified PON reach and/or provide service to a greater number of ONUs and customers. Secondly is to develop new novel optical amplifier schemes to further address the scalability limitation of the CWDM-based PONs. Specifically, this work proposes and develops novel ultra wide-band hybrid Raman-Optical parametric amplifier (HROPA) schemes that operate over nearly the entire specified CWDM band to provide 340 nm bidirectional optical gain bandwidth over the amplified PON's downstream and upstream CWDM wavelength bands (about 170 nm in each direction). The performance of the proposed HROPA schemes is assessed

  3. Future Photovoltaic Power Generation for Space-Based Power Utilities

    NASA Astrophysics Data System (ADS)

    Bailey, S.; Landis, G.; Raffaelle, R.; Hepp, A.

    2002-01-01

    A recent NASA program, Space Solar Power Exploratory Research and Technology (SERT), investigated the technologies needed to provide cost-competitive ground baseload electrical power from space based solar energy conversion. This goal mandated low cost, light weight gigawatt (GW) power generation. Investment in solar power generation technologies would also benefit high power military, commercial and science missions. These missions are generally those involving solar electric propulsion, surface power systems to sustain an outpost or a permanent colony on the surface of the moon or mars, space based lasers or radar, or as large earth orbiting power stations which can serve as central utilities for other orbiting spacecraft, or as in the SERT program, potentially beaming power to the earth itself. This paper will discuss requirements for the two latter options, the current state of the art of space solar cells, and a variety of both evolving thin film cells as well as new technologies which may impact the future choice of space solar cells for a high power mission application. The space world has primarily transitioned to commercially available III-V (GaInP/GaAs/Ge) cells with 24-26% air mass zero (AMO) efficiencies. Research in the III-V multi-junction solar cells has focused on fabricating either lattice-mismatched materials with optimum stacking bandgaps or new lattice matched materials with optimum bandgaps. In the near term this will yield a 30% commercially available space cell and in the far term possibly a 40% cell. Cost reduction would be achieved if these cells could be grown on a silicon rather than a germanium substrate since the substrate is ~65% of the cell cost or, better yet, on a polyimide or possibly a ceramic substrate. An overview of multi-junction cell characteristics will be presented here. Thin film cells require substantially less material and have promised the advantage of large area, low cost manufacturing. However, space cell requirements

  4. Microresonator-based comb generation without an external laser source.

    PubMed

    Johnson, Adrea R; Okawachi, Yoshitomo; Lamont, Michael R E; Levy, Jacob S; Lipson, Michal; Gaeta, Alexander L

    2014-01-27

    We demonstrate a fiber-microresonator dual-cavity architecture with which we generate 880 nm of comb bandwidth without the need for a continuous-wave pump laser. Comb generation with this pumping scheme is greatly simplified as compared to pumping with a single frequency laser, and the generated combs are inherently robust due to the intrinsic feedback mechanism. Temporal and radio frequency (RF) characterization show a regime of steady comb formation that operates with reduced RF amplitude noise. The dual-cavity design is capable of being integrated on-chip and offers the potential of a turn-key broadband multiple wavelength source. PMID:24515147

  5. Optimal generation scheduling based on AHP/ANP.

    PubMed

    Momoh, J A; Zhu, Jizhong

    2003-01-01

    This paper proposes an application of the analytic hierarchy process (AHP) and analytic network process (ANP) for enhancing the selection of generating power units for appropriate price allocation in a competitive power environment. The scheme addresses adequate ranking, prioritizing, and scheduling of units before optimizing the pricing of generation units to meet a given demand. In the deregulated environment, the classical optimization techniques will be insufficient for the above-mentioned purpose. Hence, by incorporating the interaction of factors such as load demand, generating cost curve, bid/sale price, unit up/down cost, and the relative importance of different generation units, the scheme can be implemented to address the technical and nontechnical constraints in unit commitment problems. This information is easily augmented with the optimization scheme for an effective optimal decision. The scheme proposed is tested using the IEEE 39-bus test system. PMID:18238201

  6. Comments on US LMFBR steam generator base technology

    SciTech Connect

    Simmons, W.R.

    1984-01-01

    The development of steam generators for the LMFBR was recognized from the onset by the AEC, now DOE, as a difficult, challenging, and high-priority task. The highly reactive nature of sodium with water/steam requires that the sodium-water/steam boundaries of LMFBR steam generators possess a degree of leak-tightness reliability not normally attempted on a commercial scale. In addition, the LMFBR steam generator is subjected to high fluid temperatures and severe thermal transients. These requirements place great demand on materials, fabrication processes, and inspection methods; and even greater demands on the designer to provide steam generators that can meet these demanding requirements, be fabricated without unreasonable shop requirements, and tolerate off-normal effects.

  7. Simple Arduino based pulse generator design for electroporation

    NASA Astrophysics Data System (ADS)

    Sulaeman, Muhammad Yangki; Widita, Rena

    2015-09-01

    This research will discuss the design of electroporation generator using Arduino as the pulse controller. The pulse parameters are the most important thing in electroporation method, therefore many researches aimed to produce generator to control its parameters easily. Arduino will be used as the microcontroller to create low amplitude signal trigger to get the high voltage pulse for electroporation. 124.4 VDC will be used and tested in cuvette contained NaCl solution with various concentration between 0% - 1%.

  8. Generation of GHZ states with invariant-based shortcuts

    NASA Astrophysics Data System (ADS)

    Ye, Li-Xiang; Lin, Xiu; Chen, Xiang; He, Juan; Yang, Rong-Can; Liu, Hong-Yu

    2016-07-01

    A scheme is proposed to generate three-atom GHZ states by applying the inversely engineered control method on the basis of Lewis-Riesenfeld invariants. In the proposal, three atoms that have different configurations are trapped in a bimodal cavity. Numerical simulations indicate that our protocol has an obvious improvement of speed for the generation of GHZ states. Moreover, the present scheme is robust against both parameter fluctuations and dissipation.

  9. Approaches for controlling air pollutants and their environmental impacts generated from coal-based electricity generation in China.

    PubMed

    Xu, Changqing; Hong, Jinglan; Ren, Yixin; Wang, Qingsong; Yuan, Xueliang

    2015-08-01

    This study aims at qualifying air pollutants and environmental impacts generated from coal-based power plants and providing useful information for decision makers on the management of coal-based power plants in China. Results showed that approximately 9.03, 54.95, 62.08, and 12.12% of the national carbon dioxide, sulfur dioxide, nitrogen oxides, and particulate matter emissions, respectively, in 2011were generated from coal-based electricity generation. The air pollutants were mainly generated from east China because of the well-developed economy and energy-intensive industries in the region. Coal-washing technology can simply and significantly reduce the environmental burden because of the relativity low content of coal gangue and sulfur in washed coal. Optimizing the efficiency of raw materials and energy consumption is additional key factor to reduce the potential environmental impacts. In addition, improving the efficiency of air pollutants (e.g., dust, mercury, sulfur dioxide, nitrogen oxides) control system and implementing the strict requirements on air pollutants for power plants are important ways for reducing the potential environmental impacts of coal-based electricity generation in China. PMID:25903190

  10. MCM generator: a Java-based tool for generating medical metadata.

    PubMed

    Munoz, F; Hersh, W

    1998-01-01

    In a previous paper we introduced the need to implement a mechanism to facilitate the discovery of relevant Web medical documents. We maintained that the use of META tags, specifically ones that define the medical subject and resource type of a document, help towards this goal. We have now developed a tool to facilitate the generation of these tags for the authors of medical documents. Written entirely in Java, this tool makes use of the SAPHIRE server, and helps the author identify the Medical Subject Heading terms that most appropriately describe the subject of the document. Furthermore, it allows the author to generate metadata tags for the 15 elements that the Dublin Core considers as core elements in the description of a document. This paper describes the use of this tool in the cataloguing of Web and non-Web medical documents, such as images, movie, and sound files. PMID:9929299

  11. MCM generator: a Java-based tool for generating medical metadata.

    PubMed Central

    Munoz, F.; Hersh, W.

    1998-01-01

    In a previous paper we introduced the need to implement a mechanism to facilitate the discovery of relevant Web medical documents. We maintained that the use of META tags, specifically ones that define the medical subject and resource type of a document, help towards this goal. We have now developed a tool to facilitate the generation of these tags for the authors of medical documents. Written entirely in Java, this tool makes use of the SAPHIRE server, and helps the author identify the Medical Subject Heading terms that most appropriately describe the subject of the document. Furthermore, it allows the author to generate metadata tags for the 15 elements that the Dublin Core considers as core elements in the description of a document. This paper describes the use of this tool in the cataloguing of Web and non-Web medical documents, such as images, movie, and sound files. Images Figure 1 Figure 2 Figure 3 Figure 4 PMID:9929299

  12. Materials-based process tolerances for neutron generator encapsulation.

    SciTech Connect

    Berry, Ryan S.; Adolf, Douglas Brian; Stavig, Mark Edwin

    2007-10-01

    Variations in the neutron generator encapsulation process can affect functionality. However, instead of following the historical path in which the effects of process variations are assessed directly through functional tests, this study examines how material properties key to generator functionality correlate with process variations. The results of this type of investigation will be applicable to all generators and can provide insight on the most profitable paths to process and material improvements. Surprisingly, the results at this point imply that the process is quite robust, and many of the current process tolerances are perhaps overly restrictive. The good news lies in the fact that our current process ensures reproducible material properties. The bad new lies in the fact that it would be difficult to solve functional problems by changes in the process.

  13. Alternative approaches to space-based power generation

    NASA Technical Reports Server (NTRS)

    Gregory, D. L.

    1977-01-01

    Satellite Power Stations (SPS) would generate electrical power in space for terrestrial use. Their geosynchronous orbit location permits continuous microwave power transmission to ground receiving antenna farms. Eight approaches to the generation of the electrical power to be transmitted were investigated. Configurations implementing these approaches were developed through an optimization process intended to yield the lowest cost for each. A complete program was baselined for each approach, identifying required production rates, quantities of launches, required facilities, etc. Each program was costed, including the associated launches, orbital assembly, and maintenance operations. The required electric power charges to amortize these costs were calculated. They range from 26 to 82 mills/kWh (ground busbar).

  14. Hybrid propulsion based on fluid-controlled solid gas generators

    NASA Technical Reports Server (NTRS)

    Cohen, Norman S.; Strand, Leon D.

    1993-01-01

    The use of fuel-rich solid (gas generator-type) propellants for hybrid propulsion affords some design and utilization efficiency advantages. Both forward and aft liquid injection control concepts are evaluated from the operational standpoints of ballistics, throttling, stability and extinguishment. Steady-state and non-steady ballistics analyses are employed for this evaluation. Stability of solid motor operation is enhanced by fluid injection with adequate injector pressure drop. Efficient throttling and reliable extinguishment are attained through a combination of solid propellant combustion tailoring, grain design, control valves and sensors. Initial results from a laboratory-scale slab combustor, combining a gas generator propellant with gaseous oxygen injection, are also presented.

  15. Optical pendulum generator based on photomechanical liquid-crystalline actuators.

    PubMed

    Tang, Rong; Liu, Ziyi; Xu, Dandan; Liu, Jian; Yu, Li; Yu, Haifeng

    2015-04-29

    For converting light energy into electricity, an optical pendulum generator was designed by combining photomechanical movement of liquid-crystalline actuator (LCA) with Faraday's law of electromagnetic induction. Bilayer cantilever actuators were first fabricated with LDPE and LCA. Their photomechanical movement drove the attached copper coils to cut magnetic line of force generating electricity. The output electricity was proportional to the changing rate of the magnetic flux, which was greatly influenced by light intensity, film thickness, and sample size. Continuous electrical output was also achieved. This simple strategy may expand applications of photoactive materials in the capture and storage of light energy. PMID:25875214

  16. Carbon Nanotube Based Deuterium Ion Source for Improved Neutron Generators

    SciTech Connect

    Fink, R. L.; Jiang, N.; Thuesen, L.; Leung, K. N.; Antolak, A. J.

    2009-03-10

    Field ionization uses high electric fields to cause the ionization and emission of ions from the surface of a sharp electrode. We are developing a novel field ionization neutron generator using carbon nanotubes (CNT) to produce the deuterium ion current. The generator consists of three major components: a deuterium ion source made of carbon nanotubes, a smooth negatively-biased target electrode, and a secondary electron suppression system. When a negative high voltage is applied on the target electrode, a high gradient electric field is formed at the tips of the carbon nanotubes. This field is sufficiently strong to create deuterium (D) ions at or near the nanotubes which are accelerated to the target causing D-D reactions to occur and the production of neutrons. A cross magnetic field is used to suppress secondary emission electrons generated on the target surface. We have demonstrated field ionization currents of 70 nA (1 {mu}A/cm{sup 2}) at hydrogen gas pressure of 10 mTorr. We have found that the current scales proportionally with CNT area and also with the gas pressure in the range of 1 mTorr to 10 mTorr. We have demonstrated pulse cut-off times as short as 2 {mu}sec. Finally, we have shown the feasibility of generating neutrons using deuterium gas.

  17. The generation of antiphase oscillations and synchrony by a rebound-based vertebrate central pattern generator.

    PubMed

    Li, Wen-Chang; Merrison-Hort, Robert; Zhang, Hong-Yan; Borisyuk, Roman

    2014-04-23

    Many neural circuits are capable of generating multiple stereotyped outputs after different sensory inputs or neuromodulation. We have previously identified the central pattern generator (CPG) for Xenopus tadpole swimming that involves antiphase oscillations of activity between the left and right sides. Here we analyze the cellular basis for spontaneous left-right motor synchrony characterized by simultaneous bursting on both sides at twice the swimming frequency. Spontaneous synchrony bouts are rare in most tadpoles, and they instantly emerge from and switch back to swimming, most frequently within the first second after skin stimulation. Analyses show that only neurons that are active during swimming fire action potentials in synchrony, suggesting both output patterns derive from the same neural circuit. The firing of excitatory descending interneurons (dINs) leads that of other types of neurons in synchrony as it does in swimming. During synchrony, the time window between phasic excitation and inhibition is 7.9 ± 1 ms, shorter than that in swimming (41 ± 2.3 ms). The occasional, extra midcycle firing of dINs during swimming may initiate synchrony, and mismatches of timing in the left and right activity can switch synchrony back to swimming. Computer modeling supports these findings by showing that the same neural network, in which reciprocal inhibition mediates rebound firing, can generate both swimming and synchrony without circuit reconfiguration. Modeling also shows that lengthening the time window between phasic excitation and inhibition by increasing dIN synaptic/conduction delay can improve the stability of synchrony. PMID:24760866

  18. Autonomously generating operations sequences for a Mars Rover using AI-based planning

    NASA Technical Reports Server (NTRS)

    Sherwood, Rob; Mishkin, Andrew; Estlin, Tara; Chien, Steve; Backes, Paul; Cooper, Brian; Maxwell, Scott; Rabideau, Gregg

    2001-01-01

    This paper discusses a proof-of-concept prototype for ground-based automatic generation of validated rover command sequences from highlevel science and engineering activities. This prototype is based on ASPEN, the Automated Scheduling and Planning Environment. This Artificial Intelligence (AI) based planning and scheduling system will automatically generate a command sequence that will execute within resource constraints and satisfy flight rules.

  19. Data driven model generation based on computational intelligence

    NASA Astrophysics Data System (ADS)

    Gemmar, Peter; Gronz, Oliver; Faust, Christophe; Casper, Markus

    2010-05-01

    parameters with respect to a defined rating function and experimental data. To find A, we use for example a linear equation solver and RMSE-function. In practical process models, the number of Fuzzy sets and the according number of rules is fairly low. Nevertheless, creating the optimal model requires some experience. Therefore, we improved this development step by methods for automatic generation of Fuzzy sets, rules, and conclusions. Basically, the model achievement depends to a great extend on the selection of the conclusion variables. It is the aim that variables having most influence on the system reaction being considered and superfluous ones being neglected. At first, we use Kohonen maps, a specialized ANN, to identify relevant input variables from the large set of available system variables. A greedy algorithm selects a comprehensive set of dominant and uncorrelated variables. Next, the premise variables are analyzed with clustering methods (e.g. Fuzzy-C-means) and Fuzzy sets are then derived from cluster centers and outlines. The rule base is automatically constructed by permutation of the Fuzzy sets of the premise variables. Finally, the conclusion parameters are calculated and the total coverage of the input space is iteratively tested with experimental data, rarely firing rules are combined and coarse coverage of sensitive process states results in refined Fuzzy sets and rules. Results The described methods were implemented and integrated in a development system for process models. A series of models has already been built e.g. for rainfall-runoff modeling or for flood prediction (up to 72 hours) in river catchments. The models required significantly less development effort and showed advanced simulation results compared to conventional models. The models can be used operationally and simulation takes only some minutes on a standard PC e.g. for a gauge forecast (up to 72 hours) for the whole Mosel (Germany) river catchment.

  20. Two-color beam generation based on wakefield excitation

    NASA Astrophysics Data System (ADS)

    Bettoni, S.; Prat, E.; Reiche, S.

    2016-05-01

    Several beam manipulation methods have been studied and experimentally tested to generate two-color photon beams in free electron laser facilities to accommodate the user requests. We propose to use the interaction of the beam with an oscillating longitudinal wakefield source to obtain a suitable electron beam structure. The bunch generates two subpulses with different energies and delayed in time passing through a magnetic chicane after its longitudinal phase space has been modulated by the wakefield source. According to this approach the power of the emitted radiation is not degraded compared to the monochromatic beam, and the setup in the machine is quite simple because the bunch is manipulated only in the high energy section, where it is more rigid. We present the design applied to SwissFEL. We identified the parameters and the corresponding range of tunability of the time and energy separation among the two subbunches.

  1. Binary hologram generation based on shape adaptive sampling

    NASA Astrophysics Data System (ADS)

    Tsang, P. W. M.; Pan, Y.; Poon, T.-C.

    2014-05-01

    Past research has revealed that by down-sampling the projected intensity profile of a source object scene with a regular sampling lattice, a binary Fresnel hologram can be generated swiftly to preserve favorable quality on its reconstructed image. However, this method also results in a prominent textural pattern which is conflicting to the geometrical profile of the object scene, leading to an unnatural visual perception. In this paper, we shall overcome this problem with a down-sampling process that is adaptive to the geometry of the object. Experimental results demonstrate that by applying our proposed method to generate a binary hologram, the reconstructed image is rendered with a texture which abides with the shape of the three-dimensional object(s).

  2. A Bio-Based Fuel Cell for Distributed Energy Generation

    SciTech Connect

    Anthony Terrinoni; Sean Gifford

    2008-06-30

    The technology we propose consists primarily of an improved design for increasing the energy density of a certain class of bio-fuel cell (BFC). The BFCs we consider are those which harvest electrons produced by microorganisms during their metabolism of organic substrates (e.g. glucose, acetate). We estimate that our technology will significantly enhance power production (per unit volume) of these BFCs, to the point where they could be employed as stand-alone systems for distributed energy generation.

  3. Generator for ionic gallium-68 based on column chromatography

    DOEpatents

    Neirinckx, Rudi D.; Davis, Michael A.

    1981-01-01

    A physiologically acceptable solution of gallium-68 fluorides, having an activity of 0.1 to 50 millicuries per milliliter of solution is provided. The solution is obtained from a generator comprising germanium-68 hexafluoride bound to a column of an anion exchange resin which forms gallium-68 in situ by eluting the column with an acid solution to form a solution containing .sup.68 Ga-fluorides. The solution then is neutralized prior to administration.

  4. Intelligent scenario generation for simulation-based training

    NASA Technical Reports Server (NTRS)

    Loftin, R. Bowen; Wang, Lui; Baffes, Paul

    1989-01-01

    A training scenario generator object database was developed to serve as a general-purpose mechanism for constructing the context needed to define a simulation scenario. It is found that the ability to automate the development of the input parameters required to produce a challenging simulation scenario targeted at a specific trainee can greatly enhance the efficiency of intelligent training systems. The approach described was used successfully in the payload-assist module deploy/intelligent computer-aided training system.

  5. A Robot Emotion Generation Mechanism Based on PAD Emotion Space

    NASA Astrophysics Data System (ADS)

    Qingji, Gao; Kai, Wang; Haijuan, Liu

    A robot emotion generation mechanism is presented in this paper, in which emotion is described in PAD emotion space. In this mechanism, emotion is affected by the robot personality, the robot task and the emotion origin, so the robot emotion will change naturally when it senses the extern stimuli. We also experiment on Fuwa robot, and demonstrate that this mechanism can make the robot's emotion change be more easily accepted by people and is good for human-robot interaction.

  6. Environmentally friendly natural materials-based photoacid generators for next-generation photolithography

    NASA Astrophysics Data System (ADS)

    Cho, Youngjin; Ouyang, Christine Y.; Krysak, Marie; Sun, Wenjie; Gamez, Victor; Sierra-Alvarez, Reyes; Ober, Christopher K.

    2011-04-01

    We describe the development of new triphenylsulfonium photoacid generators (TPS PAGs) with semifluorinated sulfonate anions containing glucose or other natural product groups, and their successful application to patterning sub-100 nm features using 254 nm and e-beam lithography. The TPS PAGs with functionalized octafluoro-3-oxapentanesulfonate were synthesized efficiently in high purity and high yield by utilizing simple and unique chemistries on 5-iodooctafluoro-3-oxapentanesulfonyl fluoride. The PAGs has been fully evaluated in terms of chemical properties, lithographic performance, environmental friendliness or toxicological impact. The PAGs are non-toxic and it is susceptible to chemical degradation and to microbial attack under aerobic/anaerobic conditions. These new PAGs are very attractive materials for high resolution photoresist applications and they are particularly useful in addressing the environmental concerns caused by PFOS and other perfluoroalkyl surfactants.

  7. Intense coherent terahertz generation from accelerator-based sources

    NASA Astrophysics Data System (ADS)

    Hama, Hiroyuki; Yasuda, Mafuyu; Kawai, Masayuki; Hinode, Fujio; Nanbu, Kenichi; Miyahara, Fusashi

    2011-05-01

    The development of terahertz (THz) technology and science relevant to accelerator-based sources has been rapid, based on laser and semiconductor physics. To assure further progress of this scientific field, extremely intense radiation, involving gigawatt-class peak power, is needed. In addition to discussing the prospects for typical accelerator-based THz sources, such as coherent synchrotron radiation (CSR) and free electron lasers (FELs), novel, advanced THz sources employing isochronous-ring and bunched-FEL approaches are proposed.

  8. Towards Next Generation Activity-Based Learning Systems

    ERIC Educational Resources Information Center

    Sampson, Demetrios G.; Karampiperis, Pythagoras

    2006-01-01

    The need for e-learning systems that support a diverse set of pedagogical requirements has been identified as an important issue in web-based education. Until now, significant research and development effort has been devoted to aiming towards web-based educational systems tailored to specific pedagogical approaches. The most advanced of them are…

  9. The comparative effect of individually-generated vs. collaboratively-generated computer-based concept mapping on science concept learning

    NASA Astrophysics Data System (ADS)

    Kwon, So Young

    Using a quasi-experimental design, the researcher investigated the comparative effects of individually-generated and collaboratively-generated computer-based concept mapping on middle school science concept learning. Qualitative data were analyzed to explain quantitative findings. One hundred sixty-one students (74 boys and 87 girls) in eight, seventh grade science classes at a middle school in Southeast Texas completed the entire study. Using prior science performance scores to assure equivalence of student achievement across groups, the researcher assigned the teacher's classes to one of the three experimental groups. The independent variable, group, consisted of three levels: 40 students in a control group, 59 students trained to individually generate concept maps on computers, and 62 students trained to collaboratively generate concept maps on computers. The dependent variables were science concept learning as demonstrated by comprehension test scores, and quality of concept maps created by students in experimental groups as demonstrated by rubric scores. Students in the experimental groups received concept mapping training and used their newly acquired concept mapping skills to individually or collaboratively construct computer-based concept maps during study time. The control group, the individually-generated concept mapping group, and the collaboratively-generated concept mapping group had equivalent learning experiences for 50 minutes during five days, excepting that students in a control group worked independently without concept mapping activities, students in the individual group worked individually to construct concept maps, and students in the collaborative group worked collaboratively to construct concept maps during their study time. Both collaboratively and individually generated computer-based concept mapping had a positive effect on seventh grade middle school science concept learning but neither strategy was more effective than the other. However

  10. Optical Frequency Comb Generation based on Erbium Fiber Lasers

    NASA Astrophysics Data System (ADS)

    Droste, Stefan; Ycas, Gabriel; Washburn, Brian R.; Coddington, Ian; Newbury, Nathan R.

    2016-06-01

    Optical frequency combs have revolutionized optical frequency metrology and are being actively investigated in a number of applications outside of pure optical frequency metrology. For reasons of cost, robustness, performance, and flexibility, the erbium fiber laser frequency comb has emerged as the most commonly used frequency comb system and many different designs of erbium fiber frequency combs have been demonstrated. We review the different approaches taken in the design of erbium fiber frequency combs, including the major building blocks of the underlying mode-locked laser, amplifier, supercontinuum generation and actuators for stabilization of the frequency comb.

  11. Quantum-network generation based on four-wave mixing

    NASA Astrophysics Data System (ADS)

    Cai, Yin; Feng, Jingliang; Wang, Hailong; Ferrini, Giulia; Xu, Xinye; Jing, Jietai; Treps, Nicolas

    2015-01-01

    We present a scheme to realize versatile quantum networks by cascading several four-wave mixing (FWM) processes in warm rubidium vapors. FWM is an efficient χ(3 ) nonlinear process, already used as a resource for multimode quantum state generation and which has been proved to be a promising candidate for applications to quantum information processing. We analyze theoretically the multimode output of cascaded FWM systems, derive its independent squeezed modes, and show how, with phase controlled homodyne detection and digital postprocessing, they can be turned into a versatile source of continuous variable cluster states.

  12. Optical cross-correlator based on supercontinuum generation

    SciTech Connect

    Filip, Catalin V.; Toth, Csaba; Leemans, Wim P.

    2006-03-20

    A novel cross-correlator that can be used for temporal characterization of femtosecond laser pulses has been developed. The correlation trace is obtained by ''sampling'' the structure of the laser pulse with a single, high-contrast pulse produced through femtosecond white-light generation in a line focus. This correlator has, therefore, fewer ''ghosts'' than a conventional third-order cross-correlator and it can be used with laser pulses that span across a wide wavelength range. Both scanning and single-shot experimental arrangements are described.

  13. Third generation photovoltaics based on multiple exciton generation in quantum confined semiconductors.

    PubMed

    Beard, Matthew C; Luther, Joseph M; Semonin, Octavi E; Nozik, Arthur J

    2013-06-18

    Improving the primary photoconversion process in a photovoltaiccell by utilizing the excess energy that is otherwise lost as heat can lead to an increase in the overall power conversion efficiency (PCE). Semiconductor nanocrystals (NCs) with at least one dimension small enough to produce quantum confinement effects provide new ways of controlling energy flow not achievable in thin film or bulk semiconductors. Researchers have developed various strategies to incorporate these novel structures into suitable solar conversion systems. Some of these methods could increase the PCE past the Shockley-Queisser (SQ) limit of ∼33%, making them viable "third generation photovoltaic" (TGPV) cell architectures. Surpassing the SQ limit for single junction solar cells presents both a scientific and a technological challenge, and the use of semiconductor NCs to enhance the primary photoconversion process offers a promising potential solution. The NCs are synthesized via solution phase chemical reactions producing stable colloidal solutions, where the reaction conditions can be modified to produce a variety of shapes, compositions, and structures. The confinement of the semiconductor NC in one dimension produces quantum films, wells, or discs. Two-dimensional confinement leads to quantum wires or rods (QRs), and quantum dots (QDs) are three-dimensionally confined NCs. The process of multiple exciton generation (MEG) converts a high-energy photon into multiple electron-hole pairs. Although many studies have demonstrated that MEG is enhanced in QDs compared with bulk semiconductors, these studies have either used ultrafast spectroscopy to measure the photon-to-exciton quantum yields (QYs) or theoretical calculations. Implementing MEG in a working solar cell has been an ongoing challenge. In this Account, we discuss the status of MEG research and strategies towards implementing MEG in working solar cells. Recently we showed an external quantum efficiency for photocurrent of greater

  14. Alkaline static feed electrolyzer based oxygen generation system

    NASA Technical Reports Server (NTRS)

    Noble, L. D.; Kovach, A. J.; Fortunato, F. A.; Schubert, F. H.; Grigger, D. J.

    1988-01-01

    In preparation for the future deployment of the Space Station, an R and D program was established to demonstrate integrated operation of an alkaline Water Electrolysis System and a fuel cell as an energy storage device. The program's scope was revised when the Space Station Control Board changed the energy storage baseline for the Space Station. The new scope was aimed at the development of an alkaline Static Feed Electrolyzer for use in an Environmental Control/Life Support System as an oxygen generation system. As a result, the program was divided into two phases. The phase 1 effort was directed at the development of the Static Feed Electrolyzer for application in a Regenerative Fuel Cell System. During this phase, the program emphasized incorporation of the Regenerative Fuel Cell System design requirements into the Static Feed Electrolyzer electrochemical module design and the mechanical components design. The mechanical components included a Pressure Control Assembly, a Water Supply Assembly and a Thermal Control Assembly. These designs were completed through manufacturing drawing during Phase 1. The Phase 2 effort was directed at advancing the Alkaline Static Feed Electrolyzer database for an oxygen generation system. This development was aimed at extending the Static Feed Electrolyzer database in areas which may be encountered from initial fabrication through transportation, storage, launch and eventual Space Station startup. During this Phase, the Program emphasized three major areas: materials evaluation, electrochemical module scaling and performance repeatability and Static Feed Electrolyzer operational definition and characterization.

  15. Mobile testing complex based on an explosive magnetic generator

    NASA Astrophysics Data System (ADS)

    Shurupov, A. V.; Kozlov, A. V.; Gusev, A. N.; Shurupova, N. P.; Zavalova, V. E.; Chulkov, A. N.; Bazelyan, E. M.

    2015-01-01

    A mobile testing complex prototype on the basis of an explosive magnetic generator (MTC EMG) is developed to simulate a lightning current pulse. The main element of this complex is a current pulse generator comprising a EMG with a pulse transformer for energy release into the load. The electric chain of the MTC EMG is theoretically analyzed taking into consideration energy losses in active resistances in the primary circuit of the transformer and the inductive-resistive nature of the load, which resulted in the minimization of energy losses in the primary circuit depending on the electric chain parameters. It was found that, if the energy losses are minimized, the efficiency of transferring the EMG energy into the load exceeds 50%. As a result of the field tests of the MTC EMG, its basic characteristics were determined and the waveforms of the current pulses and voltages in the load were obtained. It is shown that the results of the mathematical simulation of current pulses in the load are in good agreement with the experimental data.

  16. The Next Generation of Ground-based Gravitational Wave Detectors

    NASA Astrophysics Data System (ADS)

    Losurdo, Giovanni; LIGO Scientific Collaboration; Virgo Collaboration

    2007-12-01

    LIGO, Virgo and GEO600, the first generation long-baseline interferometric detectors of gravitational waves, were taking data up until last fall. The analysis of the data collected is in progress and the first detection might be possible with these instruments. But, more sensitive detectors will be needed to start the field of gravitational wave astronomy. Advanced interferometers will improve the sensitivity by a factor of ten, thus enabling the exploration of a universe volume that is 1000 times larger than the present. The technology is almost ready and the construction of Advanced LIGO and Advanced Virgo is planned to start at the beginning of the next decade. With an expected event rate of 1/week-1/day these detectors will be powerful instruments that will provide a new way of observing the universe. As an intermediate step, in 2008 LIGO and Virgo will start the upgrade of the current detectors, working towards Enhanced LIGO and Virgo+. GEO600 has also planned a set of incremental upgrades (GEO HF) in order to enhance sensitivity in the high frequency range. In this talk the path towards the advanced detectors will be reviewed and the perspectives of the so-called 2nd generation long-baseline interferometers will be outlined.

  17. Generation of arbitrary vector fields based on a pair of orthogonal elliptically polarized base vectors.

    PubMed

    Xu, Danfeng; Gu, Bing; Rui, Guanghao; Zhan, Qiwen; Cui, Yiping

    2016-02-22

    We present an arbitrary vector field with hybrid polarization based on the combination of a pair of orthogonal elliptically polarized base vectors on the Poincaré sphere. It is shown that the created vector field is only dependent on the latitude angle 2χ but is independent on the longitude angle 2ψ on the Poincaré sphere. By adjusting the latitude angle 2χ, which is related to two identical waveplates in a common path interferometric arrangement, one could obtain arbitrary type of vector fields. Experimentally, we demonstrate the generation of such kind of vector fields and confirm the distribution of state of polarization by the measurement of Stokes parameters. Besides, we investigate the tight focusing properties of these vector fields. It is found that the additional degree of freedom 2χ provided by arbitrary vector field with hybrid polarization allows one to control the spatial structure of polarization and to engineer the focusing field. PMID:26907066

  18. Earth & Space-Based Power Generation Systems - A Comparison Study

    NASA Astrophysics Data System (ADS)

    Zerta, M.; Blandow, V.; Collins, P.; Guillet, J.; Nordmann, Thomas; Schmidt, Patrick; Weindorf, Werner; Zittel, Werner

    2004-12-01

    The objective of the study [1] is to comparatively assess the economic viability, energy investment, risk and reliability issues of broad-scale introduction of terrestrial and space based solar power systems for a European power supply in 2030 at various scenario power levels. The scenario design in terms of base load and non-base load cases is only suited to gain principle knowledge about both terrestrial and space-based solar power system architectures. The comparative cost, energy, risk and reliability discussions and evaluations are based on highly asymmetrical input data due to different magnitudes of practical experiences. However, under the study assumptions given, space- based solar power systems may potentially provide a firm power supply and could be economically competitive to terrestrial solar power systems if space transportation costs in the lower hundreds EUR/kg payload are achieved. The energy payback time could be in the range of other solar power technologies far below their operational lifetimes. Risks attributed with SPS are mainly in the field of health and public acceptance of microwave power transmission, the general R&D risk and geopolitical implications.

  19. 78 FR 56690 - Seneca Generation, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Seneca Generation, LLC; Supplemental Notice That Initial Market- Based Rate...-referenced proceeding, of Seneca Generation, LLC's application for market-based rate authority, with...

  20. Development of Web-Based Learning Application for Generation Z

    ERIC Educational Resources Information Center

    Hariadi, Bambang; Dewiyani Sunarto, M. J.; Sudarmaningtyas, Pantjawati

    2016-01-01

    This study aimed to develop a web-based learning application as a form of learning revolution. The form of learning revolution includes the provision of unlimited teaching materials, real time class organization, and is not limited by time or place. The implementation of this application is in the form of hybrid learning by using Google Apps for…

  1. Generating New Knowledge Bases in Educational Administration Professional Preparation Programs.

    ERIC Educational Resources Information Center

    Powers, P. J.

    This paper examines college and university educational administration (EDAD) professional-preparation programs and their current inertia caused by an intellectually based "war over standards" of knowledge and information. It describes how much of EDAD professional-preparation programs' approach to knowledge is largely premised in conventional…

  2. CRISPR-Based Typing and Next-Generation Tracking Technologies.

    PubMed

    Barrangou, Rodolphe; Dudley, Edward G

    2016-01-01

    Bacteria occur ubiquitously in nature and are broadly relevant throughout the food supply chain, with diverse and variable tolerance levels depending on their origin, biological role, and impact on the quality and safety of the product as well as on the health of the consumer. With increasing knowledge of and accessibility to the microbial composition of our environments, food supply, and host-associated microbiota, our understanding of and appreciation for the ratio of beneficial to undesirable bacteria are rapidly evolving. Therefore, there is a need for tools and technologies that allow definite, accurate, and high-resolution identification and typing of various groups of bacteria that include beneficial microbes such as starter cultures and probiotics, innocuous commensals, and undesirable pathogens and spoilage organisms. During the transition from the current molecular biology-based PFGE (pulsed-field gel electrophoresis) gold standard to the increasingly accessible omics-level whole-genome sequencing (WGS) N-gen standard, high-resolution technologies such as CRISPR-based genotyping constitute practical and powerful alternatives that provide valuable insights into genome microevolution and evolutionary trajectories. Indeed, several studies have shown potential for CRISPR-based typing of industrial starter cultures, health-promoting probiotic strains, animal commensal species, and problematic pathogens. Emerging CRISPR-based typing methods open new avenues for high-resolution typing of a broad range of bacteria and constitute a practical means for rapid tracking of a diversity of food-associated microbes. PMID:26772411

  3. Diode-laser-based lidars: the next generation

    NASA Astrophysics Data System (ADS)

    Vujkovic-Cvijin, Pajo; Cooper, David E.; Van der Laan, Jan E.; Warren, Russell E.

    1999-10-01

    The work on the development of compact diode laser-based lidar systems at SRI International is reviewed. Two systems, a pseudorandom modulation lidar, and a mobile remote sensor for natural gas pipeline leak detection are described in detail, and experimental results are presented. Methods to enhance signal detection by digital filtering are also reviewed.

  4. Volume Based DTM Generation from Very High Resolution Photogrammetric Dsms

    NASA Astrophysics Data System (ADS)

    Piltz, B.; Bayer, S.; Poznanska, A. M.

    2016-06-01

    In this paper we propose a new algorithm for digital terrain (DTM) model reconstruction from very high spatial resolution digital surface models (DSMs). It represents a combination of multi-directional filtering with a new metric which we call normalized volume above ground to create an above-ground mask containing buildings and elevated vegetation. This mask can be used to interpolate a ground-only DTM. The presented algorithm works fully automatically, requiring only the processing parameters minimum height and maximum width in metric units. Since slope and breaklines are not decisive criteria, low and smooth and even very extensive flat objects are recognized and masked. The algorithm was developed with the goal to generate the normalized DSM for automatic 3D building reconstruction and works reliably also in environments with distinct hillsides or terrace-shaped terrain where conventional methods would fail. A quantitative comparison with the ISPRS data sets Potsdam and Vaihingen show that 98-99% of all building data points are identified and can be removed, while enough ground data points (~66%) are kept to be able to reconstruct the ground surface. Additionally, we discuss the concept of size dependent height thresholds and present an efficient scheme for pyramidal processing of data sets reducing time complexity to linear to the number of pixels, O(WH).

  5. A repetitive sequence assembler based on next-generation sequencing.

    PubMed

    Lian, S; Tu, Y; Wang, Y; Chen, X; Wang, L

    2016-01-01

    Repetitive sequences of variable length are common in almost all eukaryotic genomes, and most of them are presumed to have important biomedical functions and can cause genomic instability. Next-generation sequencing (NGS) technologies provide the possibility of identifying capturing these repetitive sequences directly from the NGS data. In this study, we assessed the performances in identifying capturing repeats of leading assemblers, such as Velvet, SOAPdenovo, SGA, MSR-CA, Bambus2, ALLPATHS-LG, and AByss using three real NGS datasets. Our results indicated that most of them performed poorly in capturing the repeats. Consequently, we proposed a repetitive sequence assembler, named NGSReper, for capturing repeats from NGS data. Simulated datasets were used to validate the feasibility of NGSReper. The results indicate that the completeness of capturing repeat is up to 99%. Cross validation was performed in three real NGS datasets, and extensive comparisons indicate that NGSReper performed best in terms of completeness and accuracy in capturing repeats. In conclusion, NGSReper is an appropriate and suitable tool for capturing repeats directly from NGS data. PMID:27525861

  6. Enhanced power quality based single phase photovoltaic distributed generation system

    NASA Astrophysics Data System (ADS)

    Panda, Aurobinda; Pathak, M. K.; Srivastava, S. P.

    2016-08-01

    This article presents a novel control strategy for a 1-ϕ 2-level grid-tie photovoltaic (PV) inverter to enhance the power quality (PQ) of a PV distributed generation (PVDG) system. The objective is to obtain the maximum benefits from the grid-tie PV inverter by introducing current harmonics as well as reactive power compensation schemes in its control strategy, thereby controlling the PV inverter to achieve multiple functions in the PVDG system such as: (1) active power flow control between the PV inverter and the grid, (2) reactive power compensation, and (3) grid current harmonics compensation. A PQ enhancement controller (PQEC) has been designed to achieve the aforementioned objectives. The issue of underutilisation of the PV inverter in nighttime has also been addressed in this article and for the optimal use of the system; the PV inverter is used as a shunt active power filter in nighttime. A prototype model of the proposed system is developed in the laboratory, to validate the effectiveness of the control scheme, and is tested with the help of the dSPACE DS1104 platform.

  7. Precise numerical modeling of next generation multimode fiber based links

    NASA Astrophysics Data System (ADS)

    Maksymiuk, L.; Stepniak, G.

    2015-12-01

    In order to numerically model modern multimode fiber based links we are required to take into account modal and chromatic dispersion, profile dispersion and spectral dependent coupling. In this paper we propose a complete numerical model which not only is precise but also versatile. Additionally to the detailed mathematical description of the model we provide also a bunch of numerical calculations performed with the use of the model.

  8. Tau Monoclonal Antibody Generation Based on Humanized Yeast Models

    PubMed Central

    Rosseels, Joëlle; Van den Brande, Jeff; Violet, Marie; Jacobs, Dirk; Grognet, Pierre; Lopez, Juan; Huvent, Isabelle; Caldara, Marina; Swinnen, Erwin; Papegaey, Anthony; Caillierez, Raphaëlle; Buée-Scherrer, Valerie; Engelborghs, Sebastiaan; Lippens, Guy; Colin, Morvane; Buée, Luc; Galas, Marie-Christine; Vanmechelen, Eugeen; Winderickx, Joris

    2015-01-01

    A link between Tau phosphorylation and aggregation has been shown in different models for Alzheimer disease, including yeast. We used human Tau purified from yeast models to generate new monoclonal antibodies, of which three were further characterized. The first antibody, ADx201, binds the Tau proline-rich region independently of the phosphorylation status, whereas the second, ADx215, detects an epitope formed by the Tau N terminus when Tau is not phosphorylated at Tyr18. For the third antibody, ADx210, the binding site could not be determined because its epitope is probably conformational. All three antibodies stained tangle-like structures in different brain sections of THY-Tau22 transgenic mice and Alzheimer patients, and ADx201 and ADx210 also detected neuritic plaques in the cortex of the patient brains. In hippocampal homogenates from THY-Tau22 mice and cortex homogenates obtained from Alzheimer patients, ADx215 consistently stained specific low order Tau oligomers in diseased brain, which in size correspond to Tau dimers. ADx201 and ADx210 additionally reacted to higher order Tau oligomers and presumed prefibrillar structures in the patient samples. Our data further suggest that formation of the low order Tau oligomers marks an early disease stage that is initiated by Tau phosphorylation at N-terminal sites. Formation of higher order oligomers appears to require additional phosphorylation in the C terminus of Tau. When used to assess Tau levels in human cerebrospinal fluid, the antibodies permitted us to discriminate patients with Alzheimer disease or other dementia like vascular dementia, indicative that these antibodies hold promising diagnostic potential. PMID:25540200

  9. A Model of Generating Visual Place Cells Based on Environment Perception and Similar Measure.

    PubMed

    Zhou, Yang; Wu, Dewei

    2016-01-01

    It is an important content to generate visual place cells (VPCs) in the field of bioinspired navigation. By analyzing the firing characteristic of biological place cells and the existing methods for generating VPCs, a model of generating visual place cells based on environment perception and similar measure is abstracted in this paper. VPCs' generation process is divided into three phases, including environment perception, similar measure, and recruiting of a new place cell. According to this process, a specific method for generating VPCs is presented. External reference landmarks are obtained based on local invariant characteristics of image and a similar measure function is designed based on Euclidean distance and Gaussian function. Simulation validates the proposed method is available. The firing characteristic of the generated VPCs is similar to that of biological place cells, and VPCs' firing fields can be adjusted flexibly by changing the adjustment factor of firing field (AFFF) and firing rate's threshold (FRT). PMID:27597859

  10. A Model of Generating Visual Place Cells Based on Environment Perception and Similar Measure

    PubMed Central

    2016-01-01

    It is an important content to generate visual place cells (VPCs) in the field of bioinspired navigation. By analyzing the firing characteristic of biological place cells and the existing methods for generating VPCs, a model of generating visual place cells based on environment perception and similar measure is abstracted in this paper. VPCs' generation process is divided into three phases, including environment perception, similar measure, and recruiting of a new place cell. According to this process, a specific method for generating VPCs is presented. External reference landmarks are obtained based on local invariant characteristics of image and a similar measure function is designed based on Euclidean distance and Gaussian function. Simulation validates the proposed method is available. The firing characteristic of the generated VPCs is similar to that of biological place cells, and VPCs' firing fields can be adjusted flexibly by changing the adjustment factor of firing field (AFFF) and firing rate's threshold (FRT). PMID:27597859

  11. A turbulence model for buoyant flows based on vorticity generation.

    SciTech Connect

    Domino, Stefan Paul; Nicolette, Vernon F.; O'Hern, Timothy John; Tieszen, Sheldon R.; Black, Amalia Rebecca

    2005-10-01

    A turbulence model for buoyant flows has been developed in the context of a k-{var_epsilon} turbulence modeling approach. A production term is added to the turbulent kinetic energy equation based on dimensional reasoning using an appropriate time scale for buoyancy-induced turbulence taken from the vorticity conservation equation. The resulting turbulence model is calibrated against far field helium-air spread rate data, and validated with near source, strongly buoyant helium plume data sets. This model is more numerically stable and gives better predictions over a much broader range of mesh densities than the standard k-{var_epsilon} model for these strongly buoyant flows.

  12. Stressor-Based Prognostics for Next Generation Systems

    SciTech Connect

    Jarrell, Donald B.; Sisk, Daniel R.; Bond, Leonard J.

    2002-04-14

    This paper reviews the evolution and current state of the maintenance art. It presents a key measurement philosophy that results from the use of Condition Based Maintenance (CBM) as a fundamental investigative precept, and how this approach impacts degradation and failure measurement and prediction accuracy. It then examines of how this measurement approach is applied in sensing and correlating pump stressors with regard to degradation rate and time to equipment failure. The specifics are examined on how this approach is currently being applied in the Laboratory to cavitation and vibration phenomena in a centrifugal pump.

  13. FEATURE-BASED MULTIBLOCK FINITE ELEMENT MESH GENERATION

    PubMed Central

    Shivanna, Kiran H.; Tadepalli, Srinivas C.; Grosland, Nicole M.

    2010-01-01

    Hexahedral finite element mesh development for anatomic structures and biomedical implants can be cumbersome. Moreover, using traditional meshing techniques, detailed features may be inadequately captured. In this paper, we describe methodologies to handle multi-feature datasets (i.e., feature edges and surfaces). Coupling multi-feature information with multiblock meshing techniques has enabled anatomic structures, as well as orthopaedic implants, to be readily meshed. Moreover, the projection process, node and element set creation are automated, thus reducing the user interaction during model development. To improve the mesh quality, Laplacian- and optimization-based mesh improvement algorithms have been adapted to the multi-feature datasets. PMID:21076650

  14. Observed bodies generate object-based spatial codes.

    PubMed

    Taylor, Alison; Flynn, Maria; Edmonds, Caroline J; Gardner, Mark R

    2016-09-01

    Contemporary studies of spatial and social cognition frequently use human figures as stimuli. The interpretation of such studies may be complicated by spatial compatibility effects that emerge when researchers employ spatial responses, and participants spontaneously code spatial relationships about an observed body. Yet, the nature of these spatial codes - whether they are location- or object-based, and coded from the perspective of the observer or the figure - has not been determined. Here, we investigated this issue by exploring spatial compatibility effects arising for objects held by a visually presented whole-bodied schematic human figure. In three experiments, participants responded to the colour of the object held in the figure's left or right hand, using left or right key presses. Left-right compatibility effects were found relative to the participant's egocentric perspective, rather than the figure's. These effects occurred even when the figure was rotated by 90° to the left or to the right, and the coloured objects were aligned with the participant's midline. These findings are consistent with spontaneous spatial coding from the participant's perspective and relative to the normal upright orientation of the body. This evidence for object-based spatial coding implies that the domain general cognitive mechanisms that result in spatial compatibility effects may contribute to certain spatial perspective-taking and social cognition phenomena. PMID:27235754

  15. A new generation of sensors based on extraordinary optical transmission.

    PubMed

    Gordon, Reuven; Sinton, David; Kavanagh, Karen L; Brolo, Alexandre G

    2008-08-01

    [Reaction: see text]. Plasmonic-based chemical sensing technologies play a key role in chemical, biochemical, and biomedical research, but basic research in this area is still attracting interest. Researchers would like to develop new types of plasmonic nanostructures that can improve the analytical figures of merit, such as detection limits, sensitivity, selectivity, and dynamic range, relative to the commercial systems. They are also tackling issues such as cost, reproducibility, and multiplexing with the goal of providing the best plasmonic-based platform for chemical analysis. In this Account, we will describe recent advances in the optical and spectroscopic properties of nanohole arrays in thin gold films and their applications for chemical sensing. These nanostructures support the unusual phenomenon of "extraordinary optical transmission" (EOT), that is, they are more transparent at certain wavelengths than expected by the classical aperture theory. The EOT is a consequence of surface plasmon (SP) excitations; hence, the resonance should respond to the adsorption of organic molecules. We explored this effect and implemented the integration of the arrays of nanoholes as sensing elements in a microfluidic architecture. We then demonstrated how these devices could be applied in biochemical affinity tests. Arrays of nanoholes offer a small sensing footprint and operate at normal transmission mode, which make them more suitable for miniaturization. This new approach for SPR sensing is more compatible with the lab-on-chip concept and offers the possibility of high-throughput analysis from a single sensing chip. We explored the field localization properties of EOT for surface-enhanced spectroscopy. We could control the enhancement factors for SERS and SEFS by adjusting the geometry of the arrays. The shape of the individual nanoholes offers another handle to tune the enhancement factor for surface-enhanced spectroscopy and SPR sensitivity. Apexes in shaped

  16. Manipulation of the generation dynamics of a microresonator-based frequency comb via selective mode filtering

    NASA Astrophysics Data System (ADS)

    Bao, Chengying; Xiao, Xiaosheng; Yang, Changxi

    2013-05-01

    We suggest a scheme to manipulate the generation dynamics of high-Q microresonator-based frequency combs (microcombs). Our simulation demonstrates that a certain subfamily of comb teeth can be suppressed via selectively filtering out limited modes, from which high-quality mode-locked pulses can be generated. Mode-pulling in microcomb generation is also analyzed quantitatively to explain the results. These results can help us better understand microcomb generation dynamics and will be beneficial in controlling the generated comb line number and spacing.

  17. Automated tools for the generation of performance-based training

    SciTech Connect

    Trainor, M.S.; Fries, J.

    1990-01-01

    The field of educational technology is not a new one, but the emphasis in the past has been on the use of technologies for the delivery of instruction and tests. This paper explores the application of technology to the development of performance-based instruction and to the analyses leading up to the development of the instruction. Several technologies are discussed, with specific software packages described. The purpose of these technologies is to streamline the instructional analysis and design process, using the computer for its strengths to aid the human-in-the-loop. Currently, the process is all accomplished manually. Applying automated tools to the process frees the humans from some of the tedium involved so that they can be dedicated to the more complex aspects of the process. 12 refs.

  18. SKYMAP system description: Star catalog data base generation and utilization

    NASA Technical Reports Server (NTRS)

    Gottlieb, D. M.

    1979-01-01

    The specifications, design, software description, and use of the SKYMAP star catalog system are detailed. The SKYMAP system was developed to provide an accurate and complete catalog of all stars with blue or visual magnitudes brighter than 9.0 for use by attitude determination programs. Because of the large number of stars which are brighter than 9.0 magnitude, efficient techniques of manipulating and accessing the data were required. These techniques of staged distillation of data from a Master Catalog to a Core Catalog, and direct access of overlapping zone catalogs, form the basis of the SKYMAP system. The collection and tranformation of data required to produce the Master Catalog data base is described. The data flow through the main programs and levels of star catalogs is detailed. The mathematical and logical techniques for each program and the format of all catalogs are documented.

  19. Brain-computer interface based on generation of visual images.

    PubMed

    Bobrov, Pavel; Frolov, Alexander; Cantor, Charles; Fedulova, Irina; Bakhnyan, Mikhail; Zhavoronkov, Alexander

    2011-01-01

    This paper examines the task of recognizing EEG patterns that correspond to performing three mental tasks: relaxation and imagining of two types of pictures: faces and houses. The experiments were performed using two EEG headsets: BrainProducts ActiCap and Emotiv EPOC. The Emotiv headset becomes widely used in consumer BCI application allowing for conducting large-scale EEG experiments in the future. Since classification accuracy significantly exceeded the level of random classification during the first three days of the experiment with EPOC headset, a control experiment was performed on the fourth day using ActiCap. The control experiment has shown that utilization of high-quality research equipment can enhance classification accuracy (up to 68% in some subjects) and that the accuracy is independent of the presence of EEG artifacts related to blinking and eye movement. This study also shows that computationally-inexpensive bayesian classifier based on covariance matrix analysis yields similar classification accuracy in this problem as a more sophisticated Multi-class Common Spatial Patterns (MCSP) classifier. PMID:21695206

  20. Substrates and pathway of electricity generation in a nitrification-based microbial fuel cell.

    PubMed

    Chen, Hui; Zheng, Ping; Zhang, Jiqiang; Xie, Zuofu; Ji, Junyuan; Ghulam, Abbas

    2014-06-01

    Nitrification-based microbial fuel cell (N-MFC) is a novel inorganic microbial fuel cell based on nitrification in the anode compartment. So far, little information is available on the substrates and pathway of N-MFC. The results of this study indicated that apart from the primary nitrification substrate (ammonium), the intermediates (hydroxylamine and nitrite) could also serve as anodic fuel to generate current, and the end product nitrate showed an inhibitory effect on electricity generation. Based on the research, a pathway of electricity generation was proposed for N-MFC: ammonium was oxidized first to nitrite by ammonia-oxidizing bacteria (AOB), then the nitrite in anolyte and the potassium permanganate in catholyte constituted a chemical cell to generate current. In other words, the electricity generation in N-MFC was not only supported by microbial reaction as we expected, but both biological and electrochemical reactions contributed. PMID:24704886

  1. Novel vibration-based electrical energy generators for low and variable speed turbo-machinery

    NASA Astrophysics Data System (ADS)

    Rastegar, J.; Murray, R.

    2007-04-01

    A novel class of vibration-based electrical energy generators is presented for applications in which the input rotary speed is relatively low and varies significantly over time such as wind mills, turbo-machinery used to harvest tidal flows, and the like. Current technology uses magnet and coil based rotary generators to generate electrical energy in such machinery. However, to make the generation cycle efficient, gearing or other similar mechanisms have to be used to increase the output speed. In addition, variable speed mechanisms are usually needed to achieve high mechanical to electrical energy conversion efficiency since speed variation is usually significant in the aforementioned applications. The objective of the present work is the development of electrical energy generators that do not require the aforementioned gearing and speed control mechanisms, thereby significantly reducing complexity and cost, particularly those related to maintenance and service. This novel class of electrical energy generators operates based on repeated vibration of multiple vibrating elements that are tuned to vibrate at a fixed prescribed frequency. The mechanical energy stored in the vibration elements is transformed into electrical energy using piezoelectric elements. The present generators are very simple, can efficiently operate over a very large range of input speeds, and should require minimal service and maintenance. The project is at the early stages of its development, but the analytical modeling and computer simulation studies using realistic system and component parameters indicate the potentials of this class of piezoelectric-based generators for the indicated applications.

  2. Internet-based Real Time Language Education: Towards a Fourth Generation Distance Education.

    ERIC Educational Resources Information Center

    Wang, Yuping; Sun, Chengzheng

    2001-01-01

    Through examination of the development of distance education for foreign languages, puts forth a theory on the emergence of a fourth generation of distance language education, challenging the generally accepted three-generation theory. Argues that with the use of Internet-based real time technology, distance language learning becomes synchronous…

  3. Knowledge Base for Automatic Generation of Online IMS LD Compliant Course Structures

    ERIC Educational Resources Information Center

    Pacurar, Ecaterina Giacomini; Trigano, Philippe; Alupoaie, Sorin

    2006-01-01

    Our article presents a pedagogical scenarios-based web application that allows the automatic generation and development of pedagogical websites. These pedagogical scenarios are represented in the IMS Learning Design standard. Our application is a web portal helping teachers to dynamically generate web course structures, to edit pedagogical content…

  4. Hairpin DNA probes based on target-induced in situ generation of luminescent silver nanoclusters.

    PubMed

    Xiao, Yan; Wu, Zhengjun; Wong, Kwok-Yin; Liu, Zhihong

    2014-05-14

    Novel hairpin DNA probes are designed and constructed based on target-induced in situ generation of luminescent silver nanoclusters. This design allows specific and versatile detection of diverse targets with easy operation and low cost. PMID:24686790

  5. Next-Generation Anchor Based Phylogeny (NexABP): Constructing phylogeny from Next-generation sequencing data

    PubMed Central

    Roychowdhury, Tanmoy; Vishnoi, Anchal; Bhattacharya, Alok

    2013-01-01

    Whole genome sequences are ideally suited for deriving evolutionary relationship among organisms. With the availability of Next Generation sequencing (NGS) datasets in an unprecedented scale, it will be highly desirable if phylogenetic analysis can be carried out using short read NGS data. We described here an anchor based approach NexABP for phylogenetic construction of closely related strains/isolates from NGS data. This approach can be used even in the absence of a fully assembled reference genome and works by reducing the complexity of the datasets without compromising results. NexABP was used for constructing phylogeny of different strains of some of the common pathogens, such as Mycobacterium tuberculosis, Vibrio cholera and Escherichia coli. In addition to classification into distinct lineages, NexABP could resolve inner branches and also allow statistical testing using bootstrap analysis. We believe that there are some clear advantages of using NexABP based phylogenetic analysis as compared to other methods. PMID:24022334

  6. Test Generation Algorithm for Fault Detection of Analog Circuits Based on Extreme Learning Machine

    PubMed Central

    Zhou, Jingyu; Tian, Shulin; Yang, Chenglin; Ren, Xuelong

    2014-01-01

    This paper proposes a novel test generation algorithm based on extreme learning machine (ELM), and such algorithm is cost-effective and low-risk for analog device under test (DUT). This method uses test patterns derived from the test generation algorithm to stimulate DUT, and then samples output responses of the DUT for fault classification and detection. The novel ELM-based test generation algorithm proposed in this paper contains mainly three aspects of innovation. Firstly, this algorithm saves time efficiently by classifying response space with ELM. Secondly, this algorithm can avoid reduced test precision efficiently in case of reduction of the number of impulse-response samples. Thirdly, a new process of test signal generator and a test structure in test generation algorithm are presented, and both of them are very simple. Finally, the abovementioned improvement and functioning are confirmed in experiments. PMID:25610458

  7. Test generation algorithm for fault detection of analog circuits based on extreme learning machine.

    PubMed

    Zhou, Jingyu; Tian, Shulin; Yang, Chenglin; Ren, Xuelong

    2014-01-01

    This paper proposes a novel test generation algorithm based on extreme learning machine (ELM), and such algorithm is cost-effective and low-risk for analog device under test (DUT). This method uses test patterns derived from the test generation algorithm to stimulate DUT, and then samples output responses of the DUT for fault classification and detection. The novel ELM-based test generation algorithm proposed in this paper contains mainly three aspects of innovation. Firstly, this algorithm saves time efficiently by classifying response space with ELM. Secondly, this algorithm can avoid reduced test precision efficiently in case of reduction of the number of impulse-response samples. Thirdly, a new process of test signal generator and a test structure in test generation algorithm are presented, and both of them are very simple. Finally, the abovementioned improvement and functioning are confirmed in experiments. PMID:25610458

  8. Communication systems, transceivers, and methods for generating data based on channel characteristics

    DOEpatents

    Forman, Michael A; Young, Derek

    2012-09-18

    Examples of methods for generating data based on a communications channel are described. In one such example, a processing unit may generate a first vector representation based in part on at least two characteristics of a communications channel. A constellation having at least two dimensions may be addressed with the first vector representation to identify a first symbol associated with the first vector representation. The constellation represents a plurality of regions, each region associated with a respective symbol. The symbol may be used to generate data, which may stored in an electronic storage medium and used as a cryptographic key or a spreading code or hopping sequence in a modulation technique.

  9. Two-bit quantum random number generator based on photon-number-resolving detection.

    PubMed

    Jian, Yi; Ren, Min; Wu, E; Wu, Guang; Zeng, Heping

    2011-07-01

    Here we present a new fast two-bit quantum random number generator based on the intrinsic randomness of the quantum physical phenomenon of photon statistics of coherent light source. Two-bit random numbers were generated according to the number of detected photons in each light pulse by a photon-number-resolving detector. Poissonian photon statistics of the coherent light source guaranteed the complete randomness of the bit sequences. Multi-bit true random numbers were generated for the first time based on the multi-photon events from a coherent light source. PMID:21806174

  10. NaBH4 generator integrated with energy conversion device based on hydrogen combustion

    NASA Astrophysics Data System (ADS)

    Netskina, O. V.; Fursenko, R. V.; Komova, O. V.; Odintsov, E. S.; Simagina, V. I.

    2015-01-01

    A thermoelectric energy conversion device operating on the heat generated by a hydrogen diffusion microflame has been developed. For the first time, a NaBH4 hydrogen generator has been employed as a source of fuel for such type of power generator. A 1%Ru-3%Co/Sibunit catalyst ensures hydrogen generation at a rate of 3 cm3 s-1 during 3 h. Power and efficiency characteristics of the integrated system consisting of a hydrogen generator and an energy converter based on combustion technologies have been studied experimentally. The total efficiency and the generated power of the system were measured to achieve values of up to 1.23% and 0.25 W, respectively. Ways to further improve the system's power output and efficiency characteristics have been discussed.

  11. Generational Sex And HIV Risk Among Indigenous Women In A Street-Based Urban Canadian Setting

    PubMed Central

    Bingham, Brittany; Leo, Diane; Zhang, Ruth; Montaner, Julio

    2014-01-01

    In Canada, indigenous women are overrepresented among new HIV infections and street-based sex workers. Scholars suggest that Aboriginal women’s HIV risk stems from intergenerational effects of colonisation and racial policies. This research examined generational sex work involvement among Aboriginal and non-Aboriginal women and the effect on risk for HIV acquisition. The sample included 225 women in street-based sex work and enrolled in a community-based prospective cohort, in partnership with local sex work and Aboriginal community partners. Bivariate and multivariate logistic regression modeled an independent relationship between Aboriginal ancestry and generational sex work; and the impact of generational sex work on HIV infection among Aboriginal sex workers. Aboriginal women (48%) were more likely to be HIV-positive, with 34% living with HIV compared to 24% non-Aboriginal. In multivariate logistic regression model, Aboriginal women remained 3 times more likely to experience generational sex work (aOR:2.97; 95%CI:1.5,5.8). Generational sex work was significantly associated with HIV (aOR=3.01, 95%CI: 1.67–4.58) in a confounder model restricted to Aboriginal women. High prevalence of generational sex work among Aboriginal women and 3-fold increased risk for HIV infection are concerning. Policy reforms and community-based, culturally safe and trauma informed HIV prevention initiatives are required for Indigenous sex workers. PMID:24654881

  12. A Novel Picosecond Pulse Generation Circuit Based on SRD and NLTL.

    PubMed

    Zhou, Jianming; Lu, Qiuyuan; Liu, Fan; Li, Yinqiao

    2016-01-01

    Because of the importance of ultra-wideband (UWB) radar in various applications, short pulse generation in UWB systems has attracted a lot of attention in recent years. In order to shorten the pulse, nonlinear transmission line (NLTL) is imported, which expands the application of step recovery diode (SRD) for pulse generation. Detailed analysis and equations for this SRD and NLTL-based pulse generation are provided and verified by simulation and experimental results. Factors that could cause pulse waveform distortions are also analyzed. The generator circuit presented in this paper generates 130ps and 3.3V pulse, which can be used in UWB radar systems that require sub-nanosecond pulses. PMID:26919290

  13. Note: Tesla based pulse generator for electrical breakdown study of liquid dielectrics

    NASA Astrophysics Data System (ADS)

    Veda Prakash, G.; Kumar, R.; Patel, J.; Saurabh, K.; Shyam, A.

    2013-12-01

    In the process of studying charge holding capability and delay time for breakdown in liquids under nanosecond (ns) time scales, a Tesla based pulse generator has been developed. Pulse generator is a combination of Tesla transformer, pulse forming line, a fast closing switch, and test chamber. Use of Tesla transformer over conventional Marx generators makes the pulse generator very compact, cost effective, and requires less maintenance. The system has been designed and developed to deliver maximum output voltage of 300 kV and rise time of the order of tens of nanoseconds. The paper deals with the system design parameters, breakdown test procedure, and various experimental results. To validate the pulse generator performance, experimental results have been compared with PSPICE simulation software and are in good agreement with simulation results.

  14. Note: Tesla based pulse generator for electrical breakdown study of liquid dielectrics.

    PubMed

    Veda Prakash, G; Kumar, R; Patel, J; Saurabh, K; Shyam, A

    2013-12-01

    In the process of studying charge holding capability and delay time for breakdown in liquids under nanosecond (ns) time scales, a Tesla based pulse generator has been developed. Pulse generator is a combination of Tesla transformer, pulse forming line, a fast closing switch, and test chamber. Use of Tesla transformer over conventional Marx generators makes the pulse generator very compact, cost effective, and requires less maintenance. The system has been designed and developed to deliver maximum output voltage of 300 kV and rise time of the order of tens of nanoseconds. The paper deals with the system design parameters, breakdown test procedure, and various experimental results. To validate the pulse generator performance, experimental results have been compared with PSPICE simulation software and are in good agreement with simulation results. PMID:24387484

  15. A Novel Picosecond Pulse Generation Circuit Based on SRD and NLTL

    PubMed Central

    Zhou, Jianming; Lu, Qiuyuan; Liu, Fan; Li, Yinqiao

    2016-01-01

    Because of the importance of ultra-wideband (UWB) radar in various applications, short pulse generation in UWB systems has attracted a lot of attention in recent years. In order to shorten the pulse, nonlinear transmission line (NLTL) is imported, which expands the application of step recovery diode (SRD) for pulse generation. Detailed analysis and equations for this SRD and NLTL-based pulse generation are provided and verified by simulation and experimental results. Factors that could cause pulse waveform distortions are also analyzed. The generator circuit presented in this paper generates 130ps and 3.3V pulse, which can be used in UWB radar systems that require sub-nanosecond pulses. PMID:26919290

  16. Recent progress in zirconia-based fuel cells for power generation

    SciTech Connect

    Singhal, S.C.

    1992-01-01

    High temperature solid oxide fuel cells based upon yttria-stabilized zirconia electrolyte offer a clean, pollution-free technology to electrochemically generate electricity at high efficiencies. This paper reviews the designs, materials and fabrication processes used for such fuel cells. Most progress to date has been achieved with tubular geometry cells. A large number of tubular cells have been electrically tested, some to times up to 30,000 hours; these cells have shown excellent performance and performance stability. In addition, successively larger size electric generators utilizing these cells have been designed, built and operated since 1984. Two 25 kW power generation field test units have recently been fabricated; these units represent a major milestone in the commercialization of zirconia-based fuel cells for power generation.

  17. Recent progress in zirconia-based fuel cells for power generation

    SciTech Connect

    Singhal, S.C.

    1992-12-01

    High temperature solid oxide fuel cells based upon yttria-stabilized zirconia electrolyte offer a clean, pollution-free technology to electrochemically generate electricity at high efficiencies. This paper reviews the designs, materials and fabrication processes used for such fuel cells. Most progress to date has been achieved with tubular geometry cells. A large number of tubular cells have been electrically tested, some to times up to 30,000 hours; these cells have shown excellent performance and performance stability. In addition, successively larger size electric generators utilizing these cells have been designed, built and operated since 1984. Two 25 kW power generation field test units have recently been fabricated; these units represent a major milestone in the commercialization of zirconia-based fuel cells for power generation.

  18. Characterization and analysis of a pulse power system based on Marx generator and Blumlein.

    PubMed

    Durga Praveen Kumar, D; Mitra, S; Senthil, K; Sharma, Archana; Nagesh, K V; Singh, S K; Mondal, J; Roy, Amitava; Chakravarthy, D P

    2007-11-01

    A pulse power system (1 MV, 50 kA, and 100 ns) based on Marx generator and Blumlein pulse forming line has been studied for characterization of a general system. Total erected Marx inductance and series resistance are calculated from modular testing of Marx generator and testing of Marx generator with Blumlein. The complete pulse power system has been tested with the termination of a liquid resistor load for finding the Blumlein characteristic impedance. Equivalent electrical circuits during the charging and discharging of the Blumlein are constructed from the characterized parameters of the system. These equivalent circuits can be used in the analysis of prepulse voltage and droop in the flat top of the main pulse in the pulse power systems based on Marx generator and Blumlein. PMID:18052504

  19. Automatic generation of fuzzy rules for the sensor-based navigation of a mobile robot

    SciTech Connect

    Pin, F.G.; Watanabe, Y.

    1994-10-01

    A system for automatic generation of fuzzy rules is proposed which is based on a new approach, called {open_quotes}Fuzzy Behaviorist,{close_quotes} and on its associated formalism for rule base development in behavior-based robot control systems. The automated generator of fuzzy rules automatically constructs the set of rules and the associated membership functions that implement reasoning schemes that have been expressed in qualitative terms. The system also checks for completeness of the rule base and independence and/or redundancy of the rules to ensure that the requirements of the formalism are satisfied. Examples of the automatic generation of fuzzy rules for cases involving suppression and/or inhibition of fuzzy behaviors are given and discussed. Experimental results obtained with the automated fuzzy rule generator applied to the domain of sensor-based navigation in a priori unknown environments using one of our autonomous test-bed robots are then presented and discussed to illustrate the feasibility of large-scale automatic fuzzy rule generation using our proposed {open_quotes}Fuzzy Behaviorist{close_quotes} approach.

  20. Assessment of Metal Media Filters for Advanced Coal-Based Power Generation Applications

    SciTech Connect

    Alvin, M.A.

    2002-09-19

    Advanced coal and biomass-based gas turbine power generation technologies (IGCC, PFBC, PCFBC, and Hipps) are currently under development and demonstration. Efforts at Siemens Westinghouse Power Corporation (SWPC) have been focused on the development and demonstration of hot gas filter systems as an enabling technology for power generation. This paper reviews SWPC's material and component assessment efforts, identifying the performance, stability, and life of porous metal, advanced alloy, and intermetallic filters under simulated, pressurized fluidized-bed combustion conditions.

  1. Time and wavelength interleaved pulse trains generation based on pure phase processing of optical spectral comb

    NASA Astrophysics Data System (ADS)

    Gao, Hongbiao; Chen, Minghua; Chen, Hongwei; Xie, Shizhong

    2014-02-01

    By applying linear phase to optical spectral comb, we experimentally demonstrate that the time interval of the compressed pulse trains with different wavelength can be precisely controlled for the generation of time and wavelength interleaved pulse train. The time and wavelength interleaved pulse train with the repetition rate of 40 GHz and 80 GHz are generated based on this and the possibility to improve the performance of the generated pulse train is also discussed. We also measure the precision of time delay obtained by applying linear phase to the comb.

  2. Novel impact-based peak-energy locking piezoelectric generators for munitions

    NASA Astrophysics Data System (ADS)

    Rastegar, J.; Murray, R.; Pereira, C.; Nguyen, H.-L.

    2007-04-01

    Presented here is an innovative class of piezoelectric-based generators for application in gun-fired munitions and other similar devices. The generators are designed to produce electrical energy as a result of the firing acceleration with enough output to power certain on-board electronic circuitry, such as lowpower fuzing. In this class of piezoelectric-based generators, a novel mechanism is provided with which the strain applied to the piezoelectric stack can be maintained at its in-firing peak value throughout the flight of the projectile. As a result, the generated charge can be harvested efficiently during a significantly longer period of time. In addition, in some munitions applications this can totally eliminate the need for storing the generated electrical energy in another storage medium. This class of impact-based piezoelectric generator devices is intrinsically robust in design which makes it suitable for high-G applications. Also, since the present devices produce energy due to the firing acceleration, a high degree of safety is guaranteed because the electronics are not powered until the projectile is fired. A basic proof-of-concept design and a deployable prototype concept are presented which will demonstrate the scalability of the present devices as well as their survivability in high-G environments.

  3. An adolescent victimization immigrant paradox? School-based routines, lifestyles, and victimization across immigration generations.

    PubMed

    Peguero, Anthony A

    2013-11-01

    There is a growing body of research that suggests parallels between assimilation and increased adolescent violence, which is often referred to as the "immigrant paradox" in the United States. Few studies explore how theories, such as routine activity and lifestyle, could explain the relationship between assimilation and increased violence. This study explores whether and how the adolescent associations between routines, lifestyles, and adolescent school-based victimization vary across immigration generations. Data are drawn from the Educational Longitudinal Study of 2002, which is a nationally representative sample of tenth graders. This study focuses on a subsample consisting of 9,870 first (N = 1,170, 12%), second (N = 1,540, 16%), and third-plus (N = 1,117, 73%) generation public school students (N = 5,050; 51% female) in 580 public schools for this analysis of routine activity, lifestyle, and school-based victimization across immigration generations. Findings do indicate important nuances related to immigration in the conceptual links between routine activity, lifestyle, and adolescent victimization. For instance, engagement in school-based sport activities is a potential risk factor for first and second generation adolescents but is found to be a potential insulating factor against violent victimization for third-plus generation adolescents. The implications of the relationships between routines, lifestyles, and violence across immigration generations are discussed more generally. PMID:23315188

  4. Adaptive Practice: Next Generation Evidence-Based Practice in Digital Environments.

    PubMed

    Kennedy, Margaret Ann

    2016-01-01

    Evidence-based practice in nursing is considered foundational to safe, competent care. To date, rigid traditional perceptions of what constitutes 'evidence' have constrained the recognition and use of practice-based evidence and the exploitation of novel forms of evidence from data rich environments. Advancements such as the conceptualization of clinical intelligence, the prevalence of increasingly sophisticated digital health information systems, and the advancement of the Big Data phenomenon have converged to generate a new contemporary context. In today's dynamic data-rich environments, clinicians have new sources of valid evidence, and need a new paradigm supporting clinical practice that is adaptive to information generated by diverse electronic sources. This opinion paper presents adaptive practice as the next generation of evidence-based practice in contemporary evidence-rich environments and provides recommendations for the next phase of evolution. PMID:27332234

  5. Bas-Relief Generation and Shape Editing through Gradient-Based Mesh Deformation.

    PubMed

    Zhang, Yu-Wei; Zhou, Yi-Qi; Li, Xue-Lin; Liu, Hui; Zhang, Li-Li

    2015-03-01

    In this paper, we introduce a novel approach to bas-relief generation and shape editing that uses gradient-based mesh deformation as the theoretical foundation. Our approach differs from image-based methods in that it operates directly on the triangular mesh, and ensures that the mesh topology remains unchanged during geometric processing. By implicitly deforming the input mesh through gradient manipulation, our approach is applicable to both plane surface bas-relief generation and curved surface bas-relief generation. We propose a series of gradient-based algorithms, such as height field deformation, high slope optimization, fine detail preservation, curved surface flattening and relief mapping. Additionally, we present two types of shape editing tools that allow the user to interactively modify the bas-relief to exhibit a desired shape. Experimental results indicate that the proposed approach is effective in producing plausible and impressive bas-reliefs. PMID:26357065

  6. Kirchhoff PSDM angle-gather generation based on the traveltime gradient

    NASA Astrophysics Data System (ADS)

    Liu, Shao-Yong; Wang, Hua-Zhong; Liu, Tai-Chen; Hu, Ying; Zhang, Cai

    2015-03-01

    Angle-domain common-image gathers (ADCIGs) are the basic data in migration velocity analysis (MVA) and amplitude variation with angle (AVA) analysis. We propose a common-angle gather-generating scheme using Kirchhoff PSDM based on the traveltime gradient field. The scheme includes three major operations: (1) to calculate the traveltime field of the source and the receiver based on the dynamic programming approach; (2) to obtain the reflection angle according to the traveltime gradient field in the image space; and (3) to generate the ADCIGs during the migration process. Because of the computation approach, the method for generating ADCIGs is superior to conventional ray-based methods. We use the proposed ADCIGs generation method in 3D large-scale seismic data. The key points of the method are the following. (1) We use common-shot datasets for migration, (2) we load traveltimes based on the shot aperture, and (3) we use the MPI and OpenMp memory sharing to decrease the amount of input and output (I/O). Numerical examples using synthetic data suggest that the ADCIGs improve the quality of the velocity and the effectiveness of the 3D angle-gather generation scheme.

  7. Auto Code Generation for Simulink-Based Attitude Determination Control System

    NASA Technical Reports Server (NTRS)

    MolinaFraticelli, Jose Carlos

    2012-01-01

    This paper details the work done to auto generate C code from a Simulink-Based Attitude Determination Control System (ADCS) to be used in target platforms. NASA Marshall Engineers have developed an ADCS Simulink simulation to be used as a component for the flight software of a satellite. This generated code can be used for carrying out Hardware in the loop testing of components for a satellite in a convenient manner with easily tunable parameters. Due to the nature of the embedded hardware components such as microcontrollers, this simulation code cannot be used directly, as it is, on the target platform and must first be converted into C code; this process is known as auto code generation. In order to generate C code from this simulation; it must be modified to follow specific standards set in place by the auto code generation process. Some of these modifications include changing certain simulation models into their atomic representations which can bring new complications into the simulation. The execution order of these models can change based on these modifications. Great care must be taken in order to maintain a working simulation that can also be used for auto code generation. After modifying the ADCS simulation for the auto code generation process, it is shown that the difference between the output data of the former and that of the latter is between acceptable bounds. Thus, it can be said that the process is a success since all the output requirements are met. Based on these results, it can be argued that this generated C code can be effectively used by any desired platform as long as it follows the specific memory requirements established in the Simulink Model.

  8. Knowledge-based reasoning in the Paladin tactical decision generation system

    NASA Technical Reports Server (NTRS)

    Chappell, Alan R.

    1993-01-01

    A real-time tactical decision generation system for air combat engagements, Paladin, has been developed. A pilot's job in air combat includes tasks that are largely symbolic. These symbolic tasks are generally performed through the application of experience and training (i.e. knowledge) gathered over years of flying a fighter aircraft. Two such tasks, situation assessment and throttle control, are identified and broken out in Paladin to be handled by specialized knowledge based systems. Knowledge pertaining to these tasks is encoded into rule-bases to provide the foundation for decisions. Paladin uses a custom built inference engine and a partitioned rule-base structure to give these symbolic results in real-time. This paper provides an overview of knowledge-based reasoning systems as a subset of rule-based systems. The knowledge used by Paladin in generating results as well as the system design for real-time execution is discussed.

  9. Photonic methods of millimeter-wave generation based on Brillouin fiber laser

    NASA Astrophysics Data System (ADS)

    Al-Dabbagh, R. K.; Al-Raweshidy, H. S.

    2016-05-01

    In optical communication link, generation and delivering millimeter-wave (mm-waves) in radio over fiber (RoF) systems has limitation due to fiber non-linearity effects. To solve this problem, photonic methods of mm-wave generation based on characterizations of Brillouin fiber laser are proposed in this work for the first time. Three novel photonic approaches for mm-wave generation methods based on Brillouin fiber laser and phase modulator are proposed and demonstrated by simulation. According to our theoretical analysis and simulation, mm-waves with frequency up to 80 GHz and good signal to noise ratio (SNR) up to 90 dB are generated by new and cost effective methods of generation that make them suitable for applications of the fifth generation (5G) networks. The proposed configurations increase the stability and the quality of the mm-wave generation system by using a single laser source as a pump wave and the fiber non-linearity effects are reduced. A key advantage of this research is that proposed a number of very simple generation methods and cost effective which only use standard components of optical telecommunications. Stimulated Brillouin Scattering (SBS) effect that exists in the optical fiber is studied with the characterization of phase modulator. An all optically stable mm-wave carriers are achieved successfully in the three different methods with different frequencies from 20 GHz up to 80 GHz. Simulation results show that all these carriers have low phase noise, good SNR ranging between 60 and 90 dB and tuning capability in comparison with previous methods reported. This makes them suitable for mm-wave transmission in RoF systems to transmit data in the next generation networks.

  10. Physics-based generation of gamma-ray response functions for CDZNTE detectors

    SciTech Connect

    Prettyman, T.H.; Mercer, D.J.; Cooper, C.; Russo, P.A.; Rawool-Sullivan, M.; Close, D.A.; Luke, P.N.; Amman, M.; Soldner, S.

    1997-09-01

    A physics-based approach to gamma-ray response-function generation is presented in which the response of CdZnTe detectors is modeled from first principles. Computer modeling is used to generate response functions needed for spectrum analysis for general detector configurations (e.g., electrode design, detector materials and geometry, and operating conditions). With computer modeling, requirements for calibration and characterization are significantly reduced. Elements of the physics-based model, including gamma-ray transport, charge drift-diffusion, and circuit response, are presented. Calculated and experimental gamma-ray spectra are compared for a coplanar-grid CdZnTe detector.

  11. Fully computed holographic stereogram based algorithm for computer-generated holograms with accurate depth cues.

    PubMed

    Zhang, Hao; Zhao, Yan; Cao, Liangcai; Jin, Guofan

    2015-02-23

    We propose an algorithm based on fully computed holographic stereogram for calculating full-parallax computer-generated holograms (CGHs) with accurate depth cues. The proposed method integrates point source algorithm and holographic stereogram based algorithm to reconstruct the three-dimensional (3D) scenes. Precise accommodation cue and occlusion effect can be created, and computer graphics rendering techniques can be employed in the CGH generation to enhance the image fidelity. Optical experiments have been performed using a spatial light modulator (SLM) and a fabricated high-resolution hologram, the results show that our proposed algorithm can perform quality reconstructions of 3D scenes with arbitrary depth information. PMID:25836429

  12. Performance Analysis of Positive-feedback-based Active Anti-islanding Schemes for Inverter-Based Distributed Generators

    SciTech Connect

    Du, Pengwei; Aponte, Erick E.; Nelson, J. Keith

    2010-06-14

    Recently proposed positive-feedback-based anti-islanding schemes (AI) are highly effective in preventing islanding without causing any degradation in power quality. This paper aims to analyze the performance of these schemes quantitatively in the context of the dynamic models of inverter-based distributed generators (DG). In this study, the characteristics of these active anti-islanding methods are discussed and design guidelines are derived.

  13. An Entirely Cell-based System to Generate Single-Chain Antibodies Against Cell Surface Receptors

    PubMed Central

    Lipes, Barbara D.; Chen, Yu-Hsun; Ma, HongZheng; Staats, Herman F.; Kenan, Daniel J.; Gunn, Michael Dee

    2008-01-01

    Summary The generation of recombinant antibodies (Abs) using phage display is a proven method to obtain a large variety of Abs that bind with high affinity to a given antigen (Ag). Traditionally, the generation of single chain Abs depends on the use of recombinant proteins in several stages of the procedure. This can be a problem, especially in the case of cell surface receptors, because Abs generated and selected against recombinant proteins may not bind the same protein expressed on a cell surface in its native form and because the expression of some receptors as recombinant proteins is problematic. To overcome these difficulties, we developed a strategy to generate single chain Abs that does not require the use of recombinant protein at any stage of the procedure. In this strategy, stably transfected cells are used for the immunization of mice, measuring Ab responses to immunization, panning the phage library, high throughput screening of arrayed phage clones, and characterization of recombinant single chain variable regions (scFvs). This strategy was used to generate a panel of single chain Abs specific for the innate immunity receptor Toll-like receptor 2 (TLR2). Once generated, individual scFvs were subcloned into an expression vector allowing the production of recombinant Abs in insect cells, thus avoiding the contamination of recombinant Abs with microbial products. This cell-based system efficiently generates Abs that bind to native molecules on the cell surface, bypasses the requirement of recombinant protein production, and avoids risks of microbial component contamination. PMID:18455737

  14. Automated protein motif generation in the structure-based protein function prediction tool ProMOL.

    PubMed

    Osipovitch, Mikhail; Lambrecht, Mitchell; Baker, Cameron; Madha, Shariq; Mills, Jeffrey L; Craig, Paul A; Bernstein, Herbert J

    2015-12-01

    ProMOL, a plugin for the PyMOL molecular graphics system, is a structure-based protein function prediction tool. ProMOL includes a set of routines for building motif templates that are used for screening query structures for enzyme active sites. Previously, each motif template was generated manually and required supervision in the optimization of parameters for sensitivity and selectivity. We developed an algorithm and workflow for the automation of motif building and testing routines in ProMOL. The algorithm uses a set of empirically derived parameters for optimization and requires little user intervention. The automated motif generation algorithm was first tested in a performance comparison with a set of manually generated motifs based on identical active sites from the same 112 PDB entries. The two sets of motifs were equally effective in identifying alignments with homologs and in rejecting alignments with unrelated structures. A second set of 296 active site motifs were generated automatically, based on Catalytic Site Atlas entries with literature citations, as an expansion of the library of existing manually generated motif templates. The new motif templates exhibited comparable performance to the existing ones in terms of hit rates against native structures, homologs with the same EC and Pfam designations, and randomly selected unrelated structures with a different EC designation at the first EC digit, as well as in terms of RMSD values obtained from local structural alignments of motifs and query structures. This research is supported by NIH grant GM078077. PMID:26573864

  15. Development of fast neutron radiography system based on portable neutron generator

    NASA Astrophysics Data System (ADS)

    Yi, Chia Jia; Nilsuwankosit, Sunchai

    2016-01-01

    Due to the high installation cost, the safety concern and the immobility of the research reactors, the neutron radiography system based on portable neutron generator is proposed. Since the neutrons generated from a portable neutron generator are mostly the fast neutrons, the system is emphasized on using the fast neutrons for the purpose of conducting the radiography. In order to suppress the influence of X-ray produced by the neutron generator, a combination of a shielding material sandwiched between two identical imaging plates is used. A binary XOR operation is then applied for combining the information from the imaging plates. The raw images obtained confirm that the X-ray really has a large effect and that XOR operation can help enhance the effect of the neutrons.

  16. Self-oscillating optical frequency comb generator based on an optoelectronic oscillator employing cascaded modulators.

    PubMed

    Dai, Jian; Xu, Xingyuan; Wu, Zhongle; Dai, Yitang; Yin, Feifei; Zhou, Yue; Li, Jianqiang; Xu, Kun

    2015-11-16

    An ultraflat self-oscillating optical frequency comb generator based on an optoelectronic oscillator employing cascaded modulators was proposed and experimentally demonstrated. By incorporating the optoelectronic oscillation loop with cascaded modulators into the optical frequency comb generator, 11 ultraflat comb lines would be generated, and the frequency spacing is equal to the oscillation frequency of the OEO. 10 and 12GHz optical frequency combs are demonstrated with the spectral power variation below 0.82dB and 0.93dB respectively. The corresponding spectral pure microwave source are also generated and evaluated. The corresponding single-sideband phase noise are as low as -122dBc/Hz and -115 dBc/Hz at 10 kHz offset frequency. PMID:26698482

  17. UWB doublet signal generation and modulation based on DFB laser under optical pulses injection

    NASA Astrophysics Data System (ADS)

    Chen, Dalei; Wang, Rong; Xiang, Peng; Pu, Tao; Fang, Tao; Zhou, Hua; Zhao, Jiyong; Huang, Long; Zhu, Huatao; Wang, Peng

    2016-05-01

    In this paper, a novel scheme to generate ultra-wideband (UWB) doublet signals based on the cross-gain modulation (XGM) effect in the DFB lasers is proposed and experimentally demonstrated, the modulation and transmission of the generated UWB doublet signals are also researched. In the proposed system, a gain-switched laser (GSL) is used as a master laser (ML) and the optical pulses from the ML are optically injected into two paralleled DFB lasers, which are used as slave lasers (SL). Then the outputs from the SLs are detected by a balanced photodiode (BPD) to generate the Bi-phased UWB signals. By properly setting the system parameters, UWB signals with various modulation formats such as on-off keying (OOK), pulse amplitude modulation (PAM) as well as the phase-shift keying (PSK) can be generated. In addition, fiber transmission of the modulated UWB signals is also experimentally investigated.

  18. Grid-connected in-stream hydroelectric generation based on the doubly fed induction machine

    NASA Astrophysics Data System (ADS)

    Lenberg, Timothy J.

    Within the United States, there is a growing demand for new environmentally friendly power generation. This has led to a surge in wind turbine development. Unfortunately, wind is not a stable prime mover, but water is. Why not apply the advances made for wind to in-stream hydroelectric generation? One important advancement is the creation of the Doubly Fed Induction Machine (DFIM). This thesis covers the application of a gearless DFIM topology for hydrokinetic generation. After providing background, this thesis presents many of the options available for the mechanical portion of the design. A mechanical turbine is then specified. Next, a method is presented for designing a DFIM including the actual design for this application. In Chapter 4, a simulation model of the system is presented, complete with a control system that maximizes power generation based on water speed. This section then goes on to present simulation results demonstrating proper operation.

  19. Truly random number generation based on measurement of phase noise of a laser.

    PubMed

    Guo, Hong; Tang, Wenzhuo; Liu, Yu; Wei, Wei

    2010-05-01

    We present a simple approach to realize truly random number generator based on measuring the phase noise of a single-mode vertical cavity surface emitting laser. The true randomness of the quantum phase noise originates from the spontaneous emission of photons and the random bit generation rate is ultimately limited only by the laser linewidth. With the final bit generation rate of 20 Mbit/s, the truly random bit sequence guaranteed by the uncertainty principle of quantum mechanics passes the three standard randomness tests (ENT, Diehard, and NIST Statistical Test Suites). Moreover, a continuously generated random bit sequence, with length up to 14 Gbit, is verified by two additional criteria for its true randomness. PMID:20866215

  20. Generating clock signals for a cycle accurate, cycle reproducible FPGA based hardware accelerator

    DOEpatents

    Asaad, Sameth W.; Kapur, Mohit

    2016-01-05

    A method, system and computer program product are disclosed for generating clock signals for a cycle accurate FPGA based hardware accelerator used to simulate operations of a device-under-test (DUT). In one embodiment, the DUT includes multiple device clocks generating multiple device clock signals at multiple frequencies and at a defined frequency ratio; and the FPG hardware accelerator includes multiple accelerator clocks generating multiple accelerator clock signals to operate the FPGA hardware accelerator to simulate the operations of the DUT. In one embodiment, operations of the DUT are mapped to the FPGA hardware accelerator, and the accelerator clock signals are generated at multiple frequencies and at the defined frequency ratio of the frequencies of the multiple device clocks, to maintain cycle accuracy between the DUT and the FPGA hardware accelerator. In an embodiment, the FPGA hardware accelerator may be used to control the frequencies of the multiple device clocks.

  1. Internal transmission coefficient in charges carrier generation layer of graphene/Si based solar cell device

    NASA Astrophysics Data System (ADS)

    Rosikhin, Ahmad; Winata, Toto

    2016-04-01

    Internal transmission profile in charges carrier generation layer of graphene/Si based solar cell has been explored theoretically. Photovoltaic device was constructed from graphene/Si heterojunction forming a multilayer stuck with Si as generation layer. The graphene/Si sheet was layered on ITO/glass wafer then coated by Al forming Ohmic contact with Si. Photon incident propagate from glass substrate to metal electrode and assumed that there is no transmission in Al layer. The wavelength range spectra used in this calculation was 200 - 1000 nm. It found that transmission intensity in the generation layer show non-linear behavior and partitioned by few areas which related with excitation process. According to this information, it may to optimize the photons absorption to create more excitation process by inserting appropriate material to enhance optical properties in certain wavelength spectra because of the exciton generation is strongly influenced by photon absorption.

  2. Genetic Algorithm-Based Test Data Generation for Multiple Paths via Individual Sharing

    PubMed Central

    Gong, Dunwei

    2014-01-01

    The application of genetic algorithms in automatically generating test data has aroused broad concerns and obtained delightful achievements in recent years. However, the efficiency of genetic algorithm-based test data generation for path testing needs to be further improved. In this paper, we establish a mathematical model of generating test data for multiple paths coverage. Then, a multipopulation genetic algorithm with individual sharing is presented to solve the established model. We not only analyzed the performance of the proposed method theoretically, but also applied it to various programs under test. The experimental results show that the proposed method can improve the efficiency of generating test data for many paths' coverage significantly. PMID:25691894

  3. Fast physical and pseudo random number generation based on a nonlinear optoelectronic oscillator

    NASA Astrophysics Data System (ADS)

    Mu, Penghua; Pan, Wei; Xiang, Shuiying; Li, Nianqiang; Liu, Xinkai; Zou, Xihua

    2015-08-01

    High speed random number generation (RNG) utilizing a nonlinear optoelectronic oscillator (OEO) is explored experimentally. It has been found that by simply adjusting either the injected optical power or the gain of the modulator driver, low complexity dynamics such as square wave, and more complex dynamics including fully developed chaos can be experimentally achieved. More importantly, physical RNG based on high-speed-oscilloscope measurements and pseudo RNG based on post-processing are implemented in this paper. The generated bit sequences pass all the standard statistical random tests, indicating that fast physical and pseudo RNG could be achieved based on the same OEO entropy source. Our results could provide further insight into the implementation of RNG based on chaotic optical systems.

  4. Pulse-forming-line based on-chip short pulse generator.

    PubMed

    Zou, Huan; Wang, Haiyang

    2015-04-01

    A traditional pulse generation circuit based on the pulse-forming-line (PFL) is implemented in a commercial 0.13 μm digital CMOS technology. A meandered on-chip coplanar waveguide is used as the PFL, and CMOS transistor is used as switch in the Cadence Spectre simulation. The circuit sample is fabricated and tested. Pulses of ∼170 ps durations and 120-200 mV amplitudes are obtained when the power supply is tuned from 1.2 V to 2 V. The results show that the traditional PFL based circuit can be implemented in standard CMOS technology for on-chip short pulse generation. Furthermore, the PFL circuits significantly extend the short pulse generation capabilities of CMOS technology. PMID:25933879

  5. Pulse-forming-line based on-chip short pulse generator

    NASA Astrophysics Data System (ADS)

    Zou, Huan; Wang, Haiyang

    2015-04-01

    A traditional pulse generation circuit based on the pulse-forming-line (PFL) is implemented in a commercial 0.13 μm digital CMOS technology. A meandered on-chip coplanar waveguide is used as the PFL, and CMOS transistor is used as switch in the Cadence Spectre simulation. The circuit sample is fabricated and tested. Pulses of ˜170 ps durations and 120-200 mV amplitudes are obtained when the power supply is tuned from 1.2 V to 2 V. The results show that the traditional PFL based circuit can be implemented in standard CMOS technology for on-chip short pulse generation. Furthermore, the PFL circuits significantly extend the short pulse generation capabilities of CMOS technology.

  6. Synchronization of random bit generators based on coupled chaotic lasers and application to cryptography.

    PubMed

    Kanter, Ido; Butkovski, Maria; Peleg, Yitzhak; Zigzag, Meital; Aviad, Yaara; Reidler, Igor; Rosenbluh, Michael; Kinzel, Wolfgang

    2010-08-16

    Random bit generators (RBGs) constitute an important tool in cryptography, stochastic simulations and secure communications. The later in particular has some difficult requirements: high generation rate of unpredictable bit strings and secure key-exchange protocols over public channels. Deterministic algorithms generate pseudo-random number sequences at high rates, however, their unpredictability is limited by the very nature of their deterministic origin. Recently, physical RBGs based on chaotic semiconductor lasers were shown to exceed Gbit/s rates. Whether secure synchronization of two high rate physical RBGs is possible remains an open question. Here we propose a method, whereby two fast RBGs based on mutually coupled chaotic lasers, are synchronized. Using information theoretic analysis we demonstrate security against a powerful computational eavesdropper, capable of noiseless amplification, where all parameters are publicly known. The method is also extended to secure synchronization of a small network of three RBGs. PMID:20721222

  7. Identification of natural images and computer-generated graphics based on statistical and textural features.

    PubMed

    Peng, Fei; Li, Jiao-ting; Long, Min

    2015-03-01

    To discriminate the acquisition pipelines of digital images, a novel scheme for the identification of natural images and computer-generated graphics is proposed based on statistical and textural features. First, the differences between them are investigated from the view of statistics and texture, and 31 dimensions of feature are acquired for identification. Then, LIBSVM is used for the classification. Finally, the experimental results are presented. The results show that it can achieve an identification accuracy of 97.89% for computer-generated graphics, and an identification accuracy of 97.75% for natural images. The analyses also demonstrate the proposed method has excellent performance, compared with some existing methods based only on statistical features or other features. The method has a great potential to be implemented for the identification of natural images and computer-generated graphics. PMID:25537575

  8. A generator for unique quantum random numbers based on vacuum states

    NASA Astrophysics Data System (ADS)

    Gabriel, Christian; Wittmann, Christoffer; Sych, Denis; Dong, Ruifang; Mauerer, Wolfgang; Andersen, Ulrik L.; Marquardt, Christoph; Leuchs, Gerd

    2010-10-01

    Random numbers are a valuable component in diverse applications that range from simulations over gambling to cryptography. The quest for true randomness in these applications has engendered a large variety of different proposals for producing random numbers based on the foundational unpredictability of quantum mechanics. However, most approaches do not consider that a potential adversary could have knowledge about the generated numbers, so the numbers are not verifiably random and unique. Here we present a simple experimental setup based on homodyne measurements that uses the purity of a continuous-variable quantum vacuum state to generate unique random numbers. We use the intrinsic randomness in measuring the quadratures of a mode in the lowest energy vacuum state, which cannot be correlated to any other state. The simplicity of our source, combined with its verifiably unique randomness, are important attributes for achieving high-reliability, high-speed and low-cost quantum random number generators.

  9. Motion Recognition and Modifying Motion Generation for Imitation Robot Based on Motion Knowledge Formation

    NASA Astrophysics Data System (ADS)

    Okuzawa, Yuki; Kato, Shohei; Kanoh, Masayoshi; Itoh, Hidenori

    A knowledge-based approach to imitation learning of motion generation for humanoid robots and an imitative motion generation system based on motion knowledge learning and modification are described. The system has three parts: recognizing, learning, and modifying parts. The first part recognizes an instructed motion distinguishing it from the motion knowledge database by the continuous hidden markov model. When the motion is recognized as being unfamiliar, the second part learns it using locally weighted regression and acquires a knowledge of the motion. When a robot recognizes the instructed motion as familiar or judges that its acquired knowledge is applicable to the motion generation, the third part imitates the instructed motion by modifying a learned motion. This paper reports some performance results: the motion imitation of several radio gymnastics motions.

  10. Design and performance evaluation of a fuzzy-logic-based variable-speed wind generation system

    SciTech Connect

    Simoes, M.G.; Bose, B.K.; Spiegel, R.J.

    1997-07-01

    Artificial intelligence techniques, such as fuzzy logic, neural network, and genetic algorithm, are recently showing a lot of promise in the application of power electronic systems. The paper describes the control strategy development, design, and experimental performance evaluation of a fuzzy-logic-based variable-speed wind generation system that uses a cage-type induction generator and double-sided pulsewidth-modulated (PWM) converters. The system can feed a utility grid maintaining unity power factor at all conditions or can supply an autonomous load. The fuzzy-logic-based control of the system helps to optimize efficiency and enhance performance. A complete 3.5-kW generation system has been developed, designed, and thoroughly evaluated by laboratory tests, in order to validate the predicted performance improvements. The system gives excellent performance and can easily be translated to a larger size in the field.

  11. Brownian motion properties of optoelectronic random bit generators based on laser chaos.

    PubMed

    Li, Pu; Yi, Xiaogang; Liu, Xianglian; Wang, Yuncai; Wang, Yongge

    2016-07-11

    The nondeterministic property of the optoelectronic random bit generator (RBG) based on laser chaos are experimentally analyzed from two aspects of the central limit theorem and law of iterated logarithm. The random bits are extracted from an optical feedback chaotic laser diode using a multi-bit extraction technique in the electrical domain. Our experimental results demonstrate that the generated random bits have no statistical distance from the Brownian motion, besides that they can pass the state-of-the-art industry-benchmark statistical test suite (NIST SP800-22). All of them give a mathematically provable evidence that the ultrafast random bit generator based on laser chaos can be used as a nondeterministic random bit source. PMID:27410852

  12. Ontology-based Software for Generating Scenarios for Characterizing Searches for Nuclear Materials

    SciTech Connect

    Ward, Richard C; Sorokine, Alexandre; Schlicher, Bob G; Wright, Michael C; Kruse, Kara L

    2011-01-01

    A software environment was created in which ontologies are used to significantly expand the number and variety of scenarios for special nuclear materials (SNM) detection based on a set of simple generalized initial descriptions. A framework was built that combined advanced reasoning from ontologies with geographical and other data sources to generate a much larger list of specific detailed descriptions from a simple initial set of user-input variables. This presentation shows how basing the scenario generation on a process of inferencing from multiple ontologies, including a new SNM Detection Ontology (DO) combined with data extraction from geodatabases, provided the desired significant variability of scenarios for testing search algorithms, including unique combinations of variables not previously expected. The various components of the software environment and the resulting scenarios generated will be discussed.

  13. Milliwatt-Power Radioisotope Thermoelectric Generator (RTG) Based on Plutonium-238

    NASA Astrophysics Data System (ADS)

    Gusev, V. V.; Pustovalov, A. A.; Rybkin, N. N.; Anatychuk, L. I.; Demchuk, B. N.; Ludchak, I. Yu.

    2011-05-01

    Results of design and experimental studies aimed at developing a milliwatt-power radioisotope thermoelectric generator (RTG) based on plutonium-238 for space power are considered and analyzed. Milliwatt-power RTGs based on plutonium-238 are completely self-contained electric power sources offering a long proven service lifetime (>15 years) and high reliability. Such electric power sources find application both for space exploration and in terrestrial equipment, especially with the advance of microsystem technologies.

  14. A New Regulatory Policy for FTTx-Based Next-Generation Access Networks

    NASA Astrophysics Data System (ADS)

    Makarovič, Boštjan

    2013-07-01

    This article critically assesses the latest European Commission policies in relation to next-generation access investment that put focus on regulated prices and relaxing of wholesale access obligations. Pointing at the vital socio-legal and economic arguments, it further challenges the assumptions of the current EU regulatory framework and calls for a more contractual utility-based model of regulation instead of the current system that overly relies on market-driven infrastructure-based competition.

  15. A search for good lattice rules based on the reciprocal lattice generator matrix

    SciTech Connect

    Lyness, J.N.; Newman, W.

    1989-01-01

    The search for cost-effective lattice rules is a time-consuming and difficult process. After a brief overview of some of the lattice theory relevant to these rules, a new approach to this search is suggested. This approach is based on a classification of lattice rules using the upper triangular lattice form'' of the reciprocal lattice generator matrix. 18 refs., 1 tab.

  16. Enhancing Learning Outcomes in Computer-Based Training via Self-Generated Elaboration

    ERIC Educational Resources Information Center

    Cuevas, Haydee M.; Fiore, Stephen M.

    2014-01-01

    The present study investigated the utility of an instructional strategy known as the "query method" for enhancing learning outcomes in computer-based training. The query method involves an embedded guided, sentence generation task requiring elaboration of key concepts in the training material that encourages learners to "stop and…

  17. Generating Random Parallel Test Forms Using CTT in a Computer-Based Environment.

    ERIC Educational Resources Information Center

    Weiner, John A.; Gibson, Wade M.

    1998-01-01

    Describes a procedure for automated-test-forms assembly based on Classical Test Theory (CTT). The procedure uses stratified random-content sampling and test-form preequating to ensure both content and psychometric equivalence in generating virtually unlimited parallel forms. Extends the usefulness of CTT in automated test construction. (Author/SLD)

  18. Droplet-based microfluidics for artificial cell generation: a brief review.

    PubMed

    Martino, Chiara; deMello, Andrew J

    2016-08-01

    Artificial cells are best defined as micrometre-sized structures able to mimic many of the morphological and functional characteristics of a living cell. In this mini-review, we describe progress in the application of droplet-based microfluidics for the generation of artificial cells and protocells. PMID:27499841

  19. Web-Based Analysis for Student-Generated Complex Genetic Profiles

    ERIC Educational Resources Information Center

    Kass, David H.; LaRoe, Robert

    2007-01-01

    A simple, rapid method for generating complex genetic profiles using Alu-based markers was recently developed for students primarily at the undergraduate level to learn more about forensics and paternity analysis. On the basis of the Cold Spring Harbor Allele Server, which provides an excellent tool for analyzing a single Alu variant, we present a…

  20. 78 FR 52913 - Allegany Generating Station LLC; Supplemental Notice That Initial Market-Based Rate Filing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Allegany Generating Station LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding...

  1. Three criteria for quantum random-number generators based on beam splitters

    SciTech Connect

    Svozil, Karl

    2009-05-15

    We propose three criteria for the generation of random digital strings from quantum beam splitters: (i) three or more mutually exclusive outcomes corresponding to the invocation of three- and higher-dimensional Hilbert spaces, (ii) the mandatory use of pure states in conjugated bases for preparation and detection, and (iii) the use of entangled singlet (unique) states for elimination of bias.

  2. Enriched Title-Based Keyword Index Generation Using dBase II.

    ERIC Educational Resources Information Center

    Rajendran, P. P.

    1986-01-01

    Describes the use of a database management system (DBMS)--dBaseII--to create an enriched title-based keyword index for a collection of news items at the Renewable Energy Resources Information Center of the Asian Institute of Technology. The use of DBMSs in libraries in developing countries is emphasized. (Author/LRW)

  3. A repetitive long-pulse power generator based on pulse forming network and linear transformer driver

    NASA Astrophysics Data System (ADS)

    Li, Mingjia; Kang, Qiang; Tan, Jie; Zhang, Faqiang; Luo, Min; Xiang, Fei

    2016-06-01

    A compact module for long-pulse power generator, based on Blumlein pulse forming network (PFN), was designed. Two Blumlein PFNs with L-type configuration and 20 Ω characteristic impedance were connected symmetrically to the primary coil of the linear transformer driver (LTD) and driven by an identical high voltage spark switch to ensure two Blumlein PFNs synchronizing operation. The output pulse of the module connected with 10 Ω water load is about 135 kV in amplitude and 200 ns in duration with a rise time of ˜50 ns and a flat top of ˜100 ns. On this basis, a repetitive long-pulse power generator based on PFN-LTD has been developed, which was composed of four modules. The following technical parameters of the generator were achieved on planar diode: output voltage amplitude of ˜560 kV, output current amplitude of ˜10 kA at a repetition rate of 25 Hz. The generator operates stable and outputs more than 104 pulses. Meanwhile, the continuous operating time of the generator is up to 60 s.

  4. A repetitive long-pulse power generator based on pulse forming network and linear transformer driver.

    PubMed

    Li, Mingjia; Kang, Qiang; Tan, Jie; Zhang, Faqiang; Luo, Min; Xiang, Fei

    2016-06-01

    A compact module for long-pulse power generator, based on Blumlein pulse forming network (PFN), was designed. Two Blumlein PFNs with L-type configuration and 20 Ω characteristic impedance were connected symmetrically to the primary coil of the linear transformer driver (LTD) and driven by an identical high voltage spark switch to ensure two Blumlein PFNs synchronizing operation. The output pulse of the module connected with 10 Ω water load is about 135 kV in amplitude and 200 ns in duration with a rise time of ∼50 ns and a flat top of ∼100 ns. On this basis, a repetitive long-pulse power generator based on PFN-LTD has been developed, which was composed of four modules. The following technical parameters of the generator were achieved on planar diode: output voltage amplitude of ∼560 kV, output current amplitude of ∼10 kA at a repetition rate of 25 Hz. The generator operates stable and outputs more than 10(4) pulses. Meanwhile, the continuous operating time of the generator is up to 60 s. PMID:27370479

  5. An 8-GW long-pulse generator based on Tesla transformer and pulse forming network.

    PubMed

    Su, Jiancang; Zhang, Xibo; Li, Rui; Zhao, Liang; Sun, Xu; Wang, Limin; Zeng, Bo; Cheng, Jie; Wang, Ying; Peng, Jianchang; Song, Xiaoxin

    2014-06-01

    A long-pulse generator TPG700L based on a Tesla transformer and a series pulse forming network (PFN) is constructed to generate intense electron beams for the purpose of high power microwave (HPM) generation. The TPG700L mainly consists of a 12-stage PFN, a built-in Tesla transformer in a pulse forming line, a three-electrode gas switch, a transmission line with a trigger, and a load. The Tesla transformer and the compact PFN are the key technologies for the development of the TPG700L. This generator can output electrical pulses with a width as long as 200 ns at a level of 8 GW and a repetition rate of 50 Hz. When used to drive a relative backward wave oscillator for HPM generation, the electrical pulse width is about 100 ns on a voltage level of 520 kV. Factors affecting the pulse waveform of the TPG700L are also discussed. At present, the TPG700L performs well for long-pulse HPM generation in our laboratory. PMID:24985810

  6. Waste generated in high-rise buildings construction: a quantification model based on statistical multiple regression.

    PubMed

    Parisi Kern, Andrea; Ferreira Dias, Michele; Piva Kulakowski, Marlova; Paulo Gomes, Luciana

    2015-05-01

    Reducing construction waste is becoming a key environmental issue in the construction industry. The quantification of waste generation rates in the construction sector is an invaluable management tool in supporting mitigation actions. However, the quantification of waste can be a difficult process because of the specific characteristics and the wide range of materials used in different construction projects. Large variations are observed in the methods used to predict the amount of waste generated because of the range of variables involved in construction processes and the different contexts in which these methods are employed. This paper proposes a statistical model to determine the amount of waste generated in the construction of high-rise buildings by assessing the influence of design process and production system, often mentioned as the major culprits behind the generation of waste in construction. Multiple regression was used to conduct a case study based on multiple sources of data of eighteen residential buildings. The resulting statistical model produced dependent (i.e. amount of waste generated) and independent variables associated with the design and the production system used. The best regression model obtained from the sample data resulted in an adjusted R(2) value of 0.694, which means that it predicts approximately 69% of the factors involved in the generation of waste in similar constructions. Most independent variables showed a low determination coefficient when assessed in isolation, which emphasizes the importance of assessing their joint influence on the response (dependent) variable. PMID:25704604

  7. Fuel-Cell Power Systems Incorporating Mg-Based H2 Generators

    NASA Technical Reports Server (NTRS)

    Kindler, Andrew; Narayan, Sri R.

    2009-01-01

    Two hydrogen generators based on reactions involving magnesium and steam have been proposed as means for generating the fuel (hydrogen gas) for such fuel-cell power systems as those to be used in the drive systems of advanced motor vehicles. The hydrogen generators would make it unnecessary to rely on any of the hydrogen storage systems developed thus far that are, variously, too expensive, too heavy, too bulky, and/or too unsafe to be practical. The two proposed hydrogen generators are denoted basic and advanced, respectively. In the basic hydrogen generator (see figure), steam at a temperature greater than or equals 330 C would be fed into a reactor charged with magnesium, wherein hydrogen would be released in the exothermic reaction Mg + H2O yields MgO + H2. The steam would be made in a flash boiler. To initiate the reaction, the boiler could be heated electrically by energy borrowed from a storage battery that would be recharged during normal operation of the associated fuel-cell subsystem. Once the reaction was underway, heat from the reaction would be fed to the boiler. If the boiler were made an integral part of the hydrogen-generator reactor vessel, then the problem of transfer of heat from the reactor to the boiler would be greatly simplified. A pump would be used to feed water from a storage tank to the boiler.

  8. An 8-GW long-pulse generator based on Tesla transformer and pulse forming network

    NASA Astrophysics Data System (ADS)

    Su, Jiancang; Zhang, Xibo; Li, Rui; Zhao, Liang; Sun, Xu; Wang, Limin; Zeng, Bo; Cheng, Jie; Wang, Ying; Peng, Jianchang; Song, Xiaoxin

    2014-06-01

    A long-pulse generator TPG700L based on a Tesla transformer and a series pulse forming network (PFN) is constructed to generate intense electron beams for the purpose of high power microwave (HPM) generation. The TPG700L mainly consists of a 12-stage PFN, a built-in Tesla transformer in a pulse forming line, a three-electrode gas switch, a transmission line with a trigger, and a load. The Tesla transformer and the compact PFN are the key technologies for the development of the TPG700L. This generator can output electrical pulses with a width as long as 200 ns at a level of 8 GW and a repetition rate of 50 Hz. When used to drive a relative backward wave oscillator for HPM generation, the electrical pulse width is about 100 ns on a voltage level of 520 kV. Factors affecting the pulse waveform of the TPG700L are also discussed. At present, the TPG700L performs well for long-pulse HPM generation in our laboratory.

  9. An 8-GW long-pulse generator based on Tesla transformer and pulse forming network

    SciTech Connect

    Su, Jiancang; Zhang, Xibo; Li, Rui; Zhao, Liang Sun, Xu; Wang, Limin; Zeng, Bo; Cheng, Jie; Wang, Ying; Peng, Jianchang; Song, Xiaoxin

    2014-06-15

    A long-pulse generator TPG700L based on a Tesla transformer and a series pulse forming network (PFN) is constructed to generate intense electron beams for the purpose of high power microwave (HPM) generation. The TPG700L mainly consists of a 12-stage PFN, a built-in Tesla transformer in a pulse forming line, a three-electrode gas switch, a transmission line with a trigger, and a load. The Tesla transformer and the compact PFN are the key technologies for the development of the TPG700L. This generator can output electrical pulses with a width as long as 200 ns at a level of 8 GW and a repetition rate of 50 Hz. When used to drive a relative backward wave oscillator for HPM generation, the electrical pulse width is about 100 ns on a voltage level of 520 kV. Factors affecting the pulse waveform of the TPG700L are also discussed. At present, the TPG700L performs well for long-pulse HPM generation in our laboratory.

  10. Autonomous Decentralized Control of Supply and Demand by Inverter Based Distributed Generations in Isolated Microgrid

    NASA Astrophysics Data System (ADS)

    Shiki, Akira; Yokoyama, Akihiko; Baba, Jyunpei; Takano, Tomihiro; Gouda, Takahiro; Izui, Yoshio

    Recently, because of the environmental burden mitigation, energy conservations, energy security, and cost reductions, distributed generations are attracting our strong attention. These distributed generations (DGs) have been already installed to the distribution system, and much more DGs will be expected to be connected in the future. On the other hand, a new concept called “Microgrid” which is a small power supply network consisting of only DGs was proposed and some prototype projects are ongoing in Japan. The purpose of this paper is to develop the three-phase instantaneous valued digital simulator of microgrid consisting of a lot of inverter based DGs and to develop a supply and demand control method in isolated microgrid. First, microgrid is modeled using MATLAB/SIMULINK. We develop models of three-phase instantaneous valued inverter type CVCF generator, PQ specified generator, PV specified generator, PQ specified load as storage battery, photovoltaic generation, fuel cell and inverter load respectively. Then we propose an autonomous decentralized control method of supply and demand in isolated microgrid where storage batteries, fuel cells, photovoltaic generations and loads are connected. It is proposed here that the system frequency is used as a means to control DG output. By changing the frequency of the storage battery due to unbalance of supply and demand, all inverter based DGs detect the frequency fluctuation and change their own outputs. Finally, a new frequency control method in autonomous decentralized control of supply and demand is proposed. Though the frequency is used to transmit the information on the supply and demand unbalance to DGs, after the frequency plays the role, the frequency finally has to return to a standard value. To return the frequency to the standard value, the characteristic curve of the fuel cell is shifted in parallel. This control is carried out corresponding to the fluctuation of the load. The simulation shows that the

  11. Second Generation MOSAIC:A Novel Mechanism Based on Reference Database for Map Updating

    NASA Astrophysics Data System (ADS)

    Hu, G.; Bignone, F.

    2011-08-01

    A totally new automatic workflow mechanism, named Second generation Mosaic module, based on the well-known Pixel Factory system, will be introduced here, which enables existing digital orthoimages and mosaics to be quickly updated. The process extracts all required parameters from the reference database to be able to perform automatic bundle adjustment and radiometric adaptation.In this paper, two examples for both satellite data and aerial data processed based on this mechanism will be presented here and discussed. Finally, the cost reduction will also be analysed according to the real mapping updating project.In a final statement, this paper will present an integrated solution named second generation mosaic module based on the well-known Pixel Factory system which is completely dedicated to fast processing of photogrammetric products Thanks to this integrated hardware and software solution, it is even possible to manage large data volume quickly in order to have precise map updating information as soon as possible after acquisition.

  12. Implementation of a computer-based test generator to evaluate health professions continuing education.

    PubMed

    Evans, S

    1984-04-01

    A variety of artificial-intelligence-based expert medical systems have been adapted to evaluate a learner's performance in the information areas in which the systems are expert. This paper describes a similar adaptation of a computer-based health sciences tutor (called the COMMES system). The Evaluation Consultant system to be described adapts the COMMES system to become a test generator. This computer-based consultant generates tests entirely on its own, covering programs of study that the COMMES system previously constructed to satisfy a user's identified needs. A health professional is awarded continuing education credits after (1) finishing a study unit constructed by COMMES and (2) completing successfully a test created by the Evaluation Consultant. This system is being implemented in several test sites and has significant advantages for the support of continuing education, especially in rural or isolated areas. PMID:6376676

  13. A test sheet generating algorithm based on intelligent genetic algorithm and hierarchical planning

    NASA Astrophysics Data System (ADS)

    Gu, Peipei; Niu, Zhendong; Chen, Xuting; Chen, Wei

    2013-03-01

    In recent years, computer-based testing has become an effective method to evaluate students' overall learning progress so that appropriate guiding strategies can be recommended. Research has been done to develop intelligent test assembling systems which can automatically generate test sheets based on given parameters of test items. A good multisubject test sheet depends on not only the quality of the test items but also the construction of the sheet. Effective and efficient construction of test sheets according to multiple subjects and criteria is a challenging problem. In this paper, a multi-subject test sheet generation problem is formulated and a test sheet generating approach based on intelligent genetic algorithm and hierarchical planning (GAHP) is proposed to tackle this problem. The proposed approach utilizes hierarchical planning to simplify the multi-subject testing problem and adopts genetic algorithm to process the layered criteria, enabling the construction of good test sheets according to multiple test item requirements. Experiments are conducted and the results show that the proposed approach is capable of effectively generating multi-subject test sheets that meet specified requirements and achieve good performance.

  14. A test sheet generating algorithm based on intelligent genetic algorithm and hierarchical planning

    NASA Astrophysics Data System (ADS)

    Gu, Peipei; Niu, Zhendong; Chen, Xuting; Chen, Wei

    2012-04-01

    In recent years, computer-based testing has become an effective method to evaluate students' overall learning progress so that appropriate guiding strategies can be recommended. Research has been done to develop intelligent test assembling systems which can automatically generate test sheets based on given parameters of test items. A good multisubject test sheet depends on not only the quality of the test items but also the construction of the sheet. Effective and efficient construction of test sheets according to multiple subjects and criteria is a challenging problem. In this paper, a multi-subject test sheet generation problem is formulated and a test sheet generating approach based on intelligent genetic algorithm and hierarchical planning (GAHP) is proposed to tackle this problem. The proposed approach utilizes hierarchical planning to simplify the multi-subject testing problem and adopts genetic algorithm to process the layered criteria, enabling the construction of good test sheets according to multiple test item requirements. Experiments are conducted and the results show that the proposed approach is capable of effectively generating multi-subject test sheets that meet specified requirements and achieve good performance.

  15. Lead-free LiNbO3 nanowire-based nanocomposite for piezoelectric power generation

    PubMed Central

    2014-01-01

    In a flexible nanocomposite-based nanogenerator, in which piezoelectric nanostructures are mixed with polymers, important parameters to increase the output power include using long nanowires with high piezoelectricity and decreasing the dielectric constant of the nanocomposite. Here, we report on piezoelectric power generation from a lead-free LiNbO3 nanowire-based nanocomposite. Through ion exchange of ultra-long Na2Nb2O6-H2O nanowires, we synthesized long (approximately 50 μm in length) single-crystalline LiNbO3 nanowires having a high piezoelectric coefficient (d33 approximately 25 pmV-1). By blending LiNbO3 nanowires with poly(dimethylsiloxane) (PDMS) polymer (volume ratio 1:100), we fabricated a flexible nanocomposite nanogenerator having a low dielectric constant (approximately 2.7). The nanogenerator generated stable electric power, even under excessive strain conditions (approximately 105 cycles). The different piezoelectric coefficients of d33 and d31 for LiNbO3 may have resulted in generated voltage and current for the e33 geometry that were 20 and 100 times larger than those for the e31 geometry, respectively. This study suggests the importance of the blending ratio and strain geometry for higher output-power generation in a piezoelectric nanocomposite-based nanogenerator. PACS 77.65.-j; 77.84.-s; 73.21.Hb PMID:24386884

  16. Development of second- and third-generation bovine immunodeficiency virus-based gene transfer systems.

    PubMed

    Matukonis, Meghan; Li, Mengtao; Molina, Rene P; Paszkiet, Brian; Kaleko, Michael; Luo, Tianci

    2002-07-20

    Lentivirus-based gene transfer systems have demonstrated their utility in mediating gene transfer to dividing and nondividing cells both in vitro and in vivo. An early-generation gene transfer system developed from bovine immunodeficiency virus (BIV) has been described (Berkowitz et al., J. Virol. 2001;75:3371-3382). In this paper, we describe the development of second-generation (three-plasmid) and third-generation (four-plasmid) BIV-based systems. All accessory genes (vif, vpw, vpy, and tmx) and the regulatory gene tat were deleted or largely truncated from the packaging construct. Furthermore, we split the packaging function into two constructs by expressing Rev in a separate plasmid. Together with our minimal BIV transfer vector construct and a vesicular stomatitis virus G glycoprotein-expressing plasmid, the BIV vectors were generated. The vectors produced by the three- and four-plasmid systems had titers greater than 1 x 10(6) transducing units per milliliter and were fully functional as indicated by their ability to efficiently transduce both dividing and nondividing cells. These results suggest that the accessory genes vif, vpw, vpy, and tmx are dispensable for functional BIV vector development. The modifications made to the packaging constructs improve the safety profile of the vector system. Finally, BIV vectors provide an alternative to human immunodeficiency virus-based gene transfer systems. PMID:12162812

  17. Graphene based widely-tunable and singly-polarized pulse generation with random fiber lasers

    PubMed Central

    Yao, B. C.; Rao, Y. J.; Wang, Z. N.; Wu, Y.; Zhou, J. H.; Wu, H.; Fan, M. Q.; Cao, X. L.; Zhang, W. L.; Chen, Y. F.; Li, Y. R.; Churkin, D.; Turitsyn, S.; Wong, C. W.

    2015-01-01

    Pulse generation often requires a stabilized cavity and its corresponding mode structure for initial phase-locking. Contrastingly, modeless cavity-free random lasers provide new possibilities for high quantum efficiency lasing that could potentially be widely tunable spectrally and temporally. Pulse generation in random lasers, however, has remained elusive since the discovery of modeless gain lasing. Here we report coherent pulse generation with modeless random lasers based on the unique polarization selectivity and broadband saturable absorption of monolayer graphene. Simultaneous temporal compression of cavity-free pulses are observed with such a polarization modulation, along with a broadly-tunable pulsewidth across two orders of magnitude down to 900 ps, a broadly-tunable repetition rate across three orders of magnitude up to 3 MHz, and a singly-polarized pulse train at 41 dB extinction ratio, about an order of magnitude larger than conventional pulsed fiber lasers. Moreover, our graphene-based pulse formation also demonstrates robust pulse-to-pulse stability and wide-wavelength operation due to the cavity-less feature. Such a graphene-based architecture not only provides a tunable pulsed random laser for fiber-optic sensing, speckle-free imaging, and laser-material processing, but also a new way for the non-random CW fiber lasers to generate widely tunable and singly-polarized pulses. PMID:26687730

  18. 2-layer based microfluidic concentration generator by hybrid serial and volumetric dilutions.

    PubMed

    Lee, Kangsun; Kim, Choong; Kim, Youngeun; Jung, Keunhui; Ahn, Byungwook; Kang, Ji Yoon; Oh, Kwang W

    2010-04-01

    We present a 2-layer based microfluidic concentration generator by a hybrid of a serial and a volumetric dilution for dose-response experiments in drug screening. The hybrid dilution method using 2-layer based microfluidic network significantly reduces the total number of cascaded serial dilution stages. The proposed strategy is capable of generating a large number of universal stepwise monotonic concentrations with a wide range of logarithmic and linear scales. We have studied an equivalent electrical circuit to that of the 2-layer based microfluidic network, where the only variable parameter is channel length. We have designed a microfluidic dilution generator simultaneously covering 14 doses with a combination of 4-order logarithmic and 4-point linear concentrations. The design has been verified by a commercial circuit analysis software (e.g., P-Spice) for the electrical circuit analysis and a computational fluid dynamics software (e.g., CFD-ACE+) for the microfluidic circuit analysis. As a real-life application of the proposed dilution generator, we have successfully performed a dose-response experiment using MCF-7 human breast cancer cells. We expect that the proposed dilution method will be useful to study not only high throughput drug screening but also optimization in biology, chemistry, medicine, and material sciences. PMID:20077018

  19. Transport model based on three-dimensional cross-section generation for TRIGA core analysis

    NASA Astrophysics Data System (ADS)

    Kriangchaiporn, Nateekool

    This dissertation addresses the development of a reactor core physics model based on 3-D transport methodology utilizing 3-D multigroup fuel lattice cross-section generation and core calculation for PSBR. The proposed 3-D transport calculation scheme for reactor core simulations is based on the TORT code. The methodology includes development of algorithms for 2-D and 3-D cross-section generation. The fine- and broad-group structures for the TRIGA cross-section generation problems were developed based on the CPXSD (Contributon and Point-wise Cross-Section Driven) methodology that selects effective group structure. Along with the study of cross section generation, the parametric studies for SN calculations were performed to evaluate the impact of the spatial meshing, angular, and scattering order variables and to obtain the suitable values for cross-section collapsing of the TRIGA cell problem. The TRIGA core loading 2 is used to verify and validate the selected effective group structures. Finally, the 13 group structure was selected to use for core calculations. The results agree with continuous energy for eigenvalues and normalized pin power distribution. The Monte Carlo solutions are used as the references.

  20. TermGenie – a web-application for pattern-based ontology class generation

    SciTech Connect

    Dietze, Heiko; Berardini, Tanya Z.; Foulger, Rebecca E.; Hill, David P.; Lomax, Jane; Osumi-Sutherland, David; Roncaglia, Paola; Mungall, Christopher J.

    2014-01-01

    Biological ontologies are continually growing and improving from requests for new classes (terms) by biocurators. These ontology requests can frequently create bottlenecks in the biocuration process, as ontology developers struggle to keep up, while manually processing these requests and create classes. TermGenie allows biocurators to generate new classes based on formally specified design patterns or templates. The system is web-based and can be accessed by any authorized curator through a web browser. Automated rules and reasoning engines are used to ensure validity, uniqueness and relationship to pre-existing classes. In the last 4 years the Gene Ontology TermGenie generated 4715 new classes, about 51.4% of all new classes created. The immediate generation of permanent identifiers proved not to be an issue with only 70 (1.4%) obsoleted classes. Lastly, TermGenie is a web-based class-generation system that complements traditional ontology development tools. All classes added through pre-defined templates are guaranteed to have OWL equivalence axioms that are used for automatic classification and in some cases inter-ontology linkage. At the same time, the system is simple and intuitive and can be used by most biocurators without extensive training.

  1. TermGenie – a web-application for pattern-based ontology class generation

    DOE PAGESBeta

    Dietze, Heiko; Berardini, Tanya Z.; Foulger, Rebecca E.; Hill, David P.; Lomax, Jane; Osumi-Sutherland, David; Roncaglia, Paola; Mungall, Christopher J.

    2014-01-01

    Biological ontologies are continually growing and improving from requests for new classes (terms) by biocurators. These ontology requests can frequently create bottlenecks in the biocuration process, as ontology developers struggle to keep up, while manually processing these requests and create classes. TermGenie allows biocurators to generate new classes based on formally specified design patterns or templates. The system is web-based and can be accessed by any authorized curator through a web browser. Automated rules and reasoning engines are used to ensure validity, uniqueness and relationship to pre-existing classes. In the last 4 years the Gene Ontology TermGenie generated 4715 newmore » classes, about 51.4% of all new classes created. The immediate generation of permanent identifiers proved not to be an issue with only 70 (1.4%) obsoleted classes. Lastly, TermGenie is a web-based class-generation system that complements traditional ontology development tools. All classes added through pre-defined templates are guaranteed to have OWL equivalence axioms that are used for automatic classification and in some cases inter-ontology linkage. At the same time, the system is simple and intuitive and can be used by most biocurators without extensive training.« less

  2. Circularly polarized carrier-envelope-phase stable attosecond pulse generation based on coherent undulator radiation.

    PubMed

    Tóth, Gy; Tibai, Z; Nagy-Csiha, Zs; Márton, Zs; Almási, G; Hebling, J

    2015-09-15

    In this Letter, we present a new method for generation of circularly polarized attosecond pulses. According to our calculations, shape-controlled, carrier-envelope-phase stable pulses of several hundred nanojoule energy could be produced by exploitation of the coherent undulator radiation of an electron bunch. Our calculations are based on an existing particle accelerator system (FLASH II in DESY, Germany). We investigated the energy dependence of the attosecond pulses on the energy of electrons and the parameters of the radiator undulator, which generate the electromagnetic radiation. PMID:26371925

  3. Analysis on the roundness of bulb turbine generator based on the unbalanced magnetic

    NASA Astrophysics Data System (ADS)

    Li, Z. G.; Yang, F. Y.; Chen, J. H.; Si, G. L.

    2012-11-01

    Because of design, manufacture, installation and operation, there are some relatively eccentric in bulb tubular turbine units under operating condition. It easily caused uneven air gap, unbalanced magnetic field, unbalanced magnetic pull and torque. It could also increase the bending and torsion vibration of generator,at the same time, the roundness of stator and rotor would be aggravated which often caused by accidents such as generator sweep chamber. In this paper, basing on the design, installation and operation experience, the reasons of the unbalanced magnetic pull, mechanism and operation research were analyzed by theoretical calculation and the prototype test.

  4. Studying dynamic chaos in microwave ring generators based on normally magnetized ferromagnetic film

    NASA Astrophysics Data System (ADS)

    Kondrashov, A. V.; Ustinov, A. B.; Kalinikos, B. A.

    2016-02-01

    We present results of an experimental investigation of the transition to a microwave dynamic chaos regime in ring oscillators based on normally magnetized yttrium iron garnet (YIG) films. It is established that an increase in the ring gain leads to the sequential generation of monochromatic, periodic, quasi-periodic, and chaotic signals. The quasi-periodic regime is characterized by the appearance of secondary modulation of the signal amplitude. In the regime of dynamic chaos generation, the parameters can be controlled by gain of the ring.

  5. Multi-wavelength generation based on cascaded Raman scattering and self-frequency-doubling in KTA

    NASA Astrophysics Data System (ADS)

    Zhong, K.; Li, J. S.; Xu, D. G.; Ding, X.; Zhou, R.; Wen, W. Q.; Li, Z. Y.; Xu, X. Y.; Wang, P.; Yao, J. Q.

    2010-04-01

    A multi-wavelength laser is developed based on cascaded stimulated Raman scattering (SRS) and self-frequency-doubling in an x-cut KTA crystal pumped by an A-O Q-switched Nd:YAG laser. The generation of 1178 nm from cascaded SRS of 234 and 671 cm-1 Raman modes is observed. The six wavelengths, including the fundamental 1064 nm, four Stokes waves at 1091, 1120, 1146, 1178 nm, and the second harmonic generation (SHG) of 1146 nm, are tens to hundreds of millwatts for each at 10 kHz, corresponding to a total conversion efficiency of 8.72%.

  6. On the applications of algebraic grid generation methods based on transfinite interpolation

    NASA Technical Reports Server (NTRS)

    Nguyen, Hung Lee

    1989-01-01

    Algebraic grid generation methods based on transfinite interpolation called the two-boundary and four-boundary methods are applied for generating grids with highly complex boundaries. These methods yield grid point distributions that allow for accurate application to regions of sharp gradients in the physical domain or time-dependent problems with small length scale phenomena. Algebraic grids are derived using the two-boundary and four-boundary methods for applications in both two- and three-dimensional domains. Grids are developed for distinctly different geometrical problems and the two-boundary and four-boundary methods are demonstrated to be applicable to a wide class of geometries.

  7. Knowledge-based approach for generating target system specifications from a domain model

    NASA Technical Reports Server (NTRS)

    Gomaa, Hassan; Kerschberg, Larry; Sugumaran, Vijayan

    1992-01-01

    Several institutions in industry and academia are pursuing research efforts in domain modeling to address unresolved issues in software reuse. To demonstrate the concepts of domain modeling and software reuse, a prototype software engineering environment is being developed at George Mason University to support the creation of domain models and the generation of target system specifications. This prototype environment, which is application domain independent, consists of an integrated set of commercial off-the-shelf software tools and custom-developed software tools. This paper describes the knowledge-based tool that was developed as part of the environment to generate target system specifications from a domain model.

  8. Generating MEDLINE search strategies using a librarian knowledge-based system.

    PubMed Central

    Peng, P.; Aguirre, A.; Johnson, S. B.; Cimino, J. J.

    1993-01-01

    We describe a librarian knowledge-based system that generates a search strategy from a query representation based on a user's information need. Together with the natural language parser AQUA, the system functions as a human/computer interface, which translates a user query from free text into a BRS Onsite search formulation, for searching the MEDLINE bibliographic database. In the system, conceptual graphs are used to represent the user's information need. The UMLS Metathesaurus and Semantic Net are used as the key knowledge sources in building the knowledge base. PMID:8130544

  9. Novel pseudo-random number generator based on quantum random walks

    PubMed Central

    Yang, Yu-Guang; Zhao, Qian-Qian

    2016-01-01

    In this paper, we investigate the potential application of quantum computation for constructing pseudo-random number generators (PRNGs) and further construct a novel PRNG based on quantum random walks (QRWs), a famous quantum computation model. The PRNG merely relies on the equations used in the QRWs, and thus the generation algorithm is simple and the computation speed is fast. The proposed PRNG is subjected to statistical tests such as NIST and successfully passed the test. Compared with the representative PRNG based on quantum chaotic maps (QCM), the present QRWs-based PRNG has some advantages such as better statistical complexity and recurrence. For example, the normalized Shannon entropy and the statistical complexity of the QRWs-based PRNG are 0.999699456771172 and 1.799961178212329e-04 respectively given the number of 8 bits-words, say, 16Mbits. By contrast, the corresponding values of the QCM-based PRNG are 0.999448131481064 and 3.701210794388818e-04 respectively. Thus the statistical complexity and the normalized entropy of the QRWs-based PRNG are closer to 0 and 1 respectively than those of the QCM-based PRNG when the number of words of the analyzed sequence increases. It provides a new clue to construct PRNGs and also extends the applications of quantum computation. PMID:26842402

  10. Novel pseudo-random number generator based on quantum random walks

    NASA Astrophysics Data System (ADS)

    Yang, Yu-Guang; Zhao, Qian-Qian

    2016-02-01

    In this paper, we investigate the potential application of quantum computation for constructing pseudo-random number generators (PRNGs) and further construct a novel PRNG based on quantum random walks (QRWs), a famous quantum computation model. The PRNG merely relies on the equations used in the QRWs, and thus the generation algorithm is simple and the computation speed is fast. The proposed PRNG is subjected to statistical tests such as NIST and successfully passed the test. Compared with the representative PRNG based on quantum chaotic maps (QCM), the present QRWs-based PRNG has some advantages such as better statistical complexity and recurrence. For example, the normalized Shannon entropy and the statistical complexity of the QRWs-based PRNG are 0.999699456771172 and 1.799961178212329e-04 respectively given the number of 8 bits-words, say, 16Mbits. By contrast, the corresponding values of the QCM-based PRNG are 0.999448131481064 and 3.701210794388818e-04 respectively. Thus the statistical complexity and the normalized entropy of the QRWs-based PRNG are closer to 0 and 1 respectively than those of the QCM-based PRNG when the number of words of the analyzed sequence increases. It provides a new clue to construct PRNGs and also extends the applications of quantum computation.

  11. Novel pseudo-random number generator based on quantum random walks.

    PubMed

    Yang, Yu-Guang; Zhao, Qian-Qian

    2016-01-01

    In this paper, we investigate the potential application of quantum computation for constructing pseudo-random number generators (PRNGs) and further construct a novel PRNG based on quantum random walks (QRWs), a famous quantum computation model. The PRNG merely relies on the equations used in the QRWs, and thus the generation algorithm is simple and the computation speed is fast. The proposed PRNG is subjected to statistical tests such as NIST and successfully passed the test. Compared with the representative PRNG based on quantum chaotic maps (QCM), the present QRWs-based PRNG has some advantages such as better statistical complexity and recurrence. For example, the normalized Shannon entropy and the statistical complexity of the QRWs-based PRNG are 0.999699456771172 and 1.799961178212329e-04 respectively given the number of 8 bits-words, say, 16Mbits. By contrast, the corresponding values of the QCM-based PRNG are 0.999448131481064 and 3.701210794388818e-04 respectively. Thus the statistical complexity and the normalized entropy of the QRWs-based PRNG are closer to 0 and 1 respectively than those of the QCM-based PRNG when the number of words of the analyzed sequence increases. It provides a new clue to construct PRNGs and also extends the applications of quantum computation. PMID:26842402

  12. Generation of artificial biometric data enhanced with contextual information for game strategy-based behavioral biometrics

    NASA Astrophysics Data System (ADS)

    Yampolskiy, Roman V.; Govindaraju, Venu

    2008-03-01

    For the domain of strategy-based behavioral biometrics we propose the concept of profiles enhanced with spatial, temporal and contextual information. Inclusion of such information leads to a more stable baseline profile and as a result more secure systems. Such enhanced data is not always readily available and often is time consuming and expensive to acquire. One solution to this problem is the use of artificially generated data. In this paper a novel methodology for creation of feature-level synthetic biometric data is presented. Specifically generation of behavioral biometric data represented by game playing strategies is demonstrated. Data validation methods are described and encouraging results are obtained with possibility of expanding proposed methodologies to generation of artificial data in the domains other then behavioral biometrics.

  13. Noise generator for tinnitus treatment based on look-up tables

    NASA Astrophysics Data System (ADS)

    Uriz, Alejandro J.; Agüero, Pablo; Tulli, Juan C.; Castiñeira Moreira, Jorge; González, Esteban; Hidalgo, Roberto; Casadei, Manuel

    2016-04-01

    Treatment of tinnitus by means of masking sounds allows to obtain a significant improve of the quality of life of the individual that suffer that condition. In view of that, it is possible to develop noise synthesizers based on random number generators in digital signal processors (DSP), which are used in almost any digital hearing aid devices. DSP architecture have limitations to implement a pseudo random number generator, due to it, the noise statistics can be not as good as expectations. In this paper, a technique to generate additive white gaussian noise (AWGN) or other types of filtered noise using coefficients stored in program memory of the DSP is proposed. Also, an implementation of the technique is carried out on a dsPIC from Microchip®. Objective experiments and experimental measurements are performed to analyze the proposed technique.

  14. Femtosecond electron and x-ray generation by laser andplasma-based sources

    SciTech Connect

    Esarey, E.; Leemans, W.P.

    2000-02-01

    The generation of ultra-short x-rays by Thomson scattering intense laser pulses from electron beams is discussed, including recent experimental results and methods for enhancing the x-ray flux. A high flux of x-rays in a femtosecond pulse requires the generation of femtosecond electron bunches and a head-on Thomson scattering geometry. The generation of ultrashort electron bunches in a plasma-based accelerator with an injection technique that uses two colliding laser pulses is discussed. Simulations indicate the bunches as short as a few fs can be produced. Conversion of the fs electron pulse to a fs x-ray pulse can be accomplished by Bremsstrahlung or Thomson scattering.

  15. Vacuum-spark metal ion source based on a modified Marx generator

    SciTech Connect

    Anders, A.; Brown, I.G.; MacGill, R.A.; Dickinson, M.R.

    1997-08-01

    The plasma-generating parts of ion sources including their power supplies are usually floated to high potential (ion extraction voltage), thus requiring great insulation efforts and causing high costs for high-energy ion beams. A new concept for pulsed ion sources is presented in which a single power supply is used to simultaneously produce the plasma and high extractor voltage via a modified Marx generator. Proof-of-principle experiments have been performed with high-current spark discharges in vacuum where multiply charged ions are produced with this Marx-generator-based ion source (Magis). Using Magis, it has been demonstrated that pulsed ion beams of very high energies can be obtained with relatively low voltage. For copper, ions of charge states up to 7+ have been found whose energy was 112 keV for a charging voltage of only 10 kV.

  16. Vacuum-spark metal ion source based on a modified Marx generator

    SciTech Connect

    Anders, A.; Brown, I.G.; MacGill, R.A.; Dickinson, M.R.

    1996-04-01

    The plasma generating parts of ion sources including their power supplies are usually floated to high potential (ion extraction voltage), thus requiring great insulation efforts and high costs for high-energy ion beams. A new concept for pulsed ion sources is presented in which a single power supply is used to simultaneously produce the plasma and high extractor voltage via a modified Marx generator. Proof-of-principle experiments have been performed with high-current spark discharges in vacuum where multiply charged ions are produced with this Marx-generator based ion source (Magis). Using Magis, it has been demonstrated that pulsed ion beams of very high energies can be obtained with relatively low voltage. For copper, ion of charge states up to 7+ have been found whose energy was 112 keV for a charging voltage of only 10 kV.

  17. Vacuum-spark metal ion source based on a modified Marx generator

    SciTech Connect

    Anders, A.; Brown, I.G.; MacGill, R.A.; Dickinson, M.R.

    1996-12-31

    The plasma generating parts of ion sources including their power supplies are usually floated to high potential (ion extraction voltage), thus requiring great insulation efforts and high costs for high-energy ion beams. A new concept for pulsed ion sources is presented in which a single power supply is used to simultaneously produce the plasma and high extractor voltage via a modified Marx generator. Proof-of-principle experiments have been performed with high-current spark discharges in vacuum where multiply charged ions are produced with this Marx-generator based ion source ({open_quotes}Magis{close_quotes}). Using {open_quotes}Magis{close_quotes}, it has been demonstrated that pulsed ion beams of very high energies can be obtained with relatively low voltage. For copper, ions of charge states up to 7+ have been found whose energy was 112 keV for a charging voltage of only 10 kV.

  18. U-shape magnetostrictive vibration based power generator for universal use

    NASA Astrophysics Data System (ADS)

    Ueno, T.

    2016-04-01

    Vibrational power generator extracts electrical energy from ambient vibration. Author invented novel configuration using magnetostrictive material. The device is based on parallel beams of iron-gallium alloy and magnetic material, and features high efficiency, high robustness, and low electrical impedance. In this paper, author proposes U-shape generator for universal use. It consists of the parallel beams and fixed and free end beams forming U-shape frame flexibly modified for variety of mechanical input. Miniature U-shape prototype using Fe-Ga rod 6 by 0.5 by 13 mm3 exhibited average power of 3.7 mW under vibration of 166 Hz and 2.5 G. L-shape type was demonstrated to generate electromotive force by two directional vibrations. In switch type, maximum energy of 0.7 mJ was retrieved by one pushing force. The performances are sufficient to drive wireless module for heath monitoring and remote control.

  19. Efficient coal-based power generation in India: A market opportunity

    SciTech Connect

    Gollakota, S.; Rao, N.; Staats, G.; Sinha, K.

    1998-07-01

    The planned addition of over 100,000 MW power generation capacity in India in the next 10 years will provide attractive business opportunities for independent power producers, engineering and consulting companies, and equipment manufacturers in the US. The US Agency for International Development (USAID) is providing, through the US Department of Energy (DOE), necessary technical and project development support to the government stakeholders (Indian Ministries of Power and Coal) and private stakeholders (Ahmedabad Electric Co. and Bombay Suburban Electric Supply) for identifying and promoting advanced clean coal technologies. Implementation of advanced technologies improves electric power generation efficiency and economics, and environmental management in India (e.g., reduces emissions of greenhouse gases and particulates, and increases byproduct utilization). This paper presents a brief overview of the coal-based power generation and related technical support activities being provided in India by the DOE's Federal Energy Technology Center and its support contractor, Burns and Roe Services Corporation.

  20. Mach-zehnder based optical marker/comb generator for streak camera calibration

    SciTech Connect

    Miller, Edward Kirk

    2015-03-03

    This disclosure is directed to a method and apparatus for generating marker and comb indicia in an optical environment using a Mach-Zehnder (M-Z) modulator. High speed recording devices are configured to record image or other data defining a high speed event. To calibrate and establish time reference, the markers or combs are indicia which serve as timing pulses (markers) or a constant-frequency train of optical pulses (comb) to be imaged on a streak camera for accurate time based calibration and time reference. The system includes a camera, an optic signal generator which provides an optic signal to an M-Z modulator and biasing and modulation signal generators configured to provide input to the M-Z modulator. An optical reference signal is provided to the M-Z modulator. The M-Z modulator modulates the reference signal to a higher frequency optical signal which is output through a fiber coupled link to the streak camera.

  1. The Next Generation Ground-based CMB experiment, CMB-S4

    NASA Astrophysics Data System (ADS)

    Carlstrom, John E.; CMB-S4 Collaboration

    2016-06-01

    This talk will review the goals and status of the community planning for the next generation ground-based CMB experiment, CMB-S4. Following the detection of CMB polarization in 2002, the current generation of ground-based experiments each fielding of order 1000 superconducting detectors (Stage II experiments) have led to the first detection of the much fainter lensing B-mode polarization signal and the most stringent constraints on the level of the B-mode signal from inflationary gravitational waves. We can expect significant advances in the next few years as the ongoing ground-based experiments deploy of order 10,000 detectors (Stage III). The CMB community is now planning an ambitious next generation (Stage IV) ground-based program with order of 500,000 detectors, CMB-S4, to achieve critical threshold crossing goals of 1) detecting or ruling out large field inflationary models, 2) determining the effective number and masses of the neutrinos, and 3) providing precision constraints on dark energy through its impact on structure formation.

  2. The Sandwich Generation Diner: Development of a Web-Based Health Intervention for Intergenerational Caregivers

    PubMed Central

    George, Nika; MacDougall, Megan

    2016-01-01

    Background Women are disproportionately likely to assist aging family members; approximately 53 million in the United States are involved with the health care of aging parents, in-laws, or other relatives. The busy schedules of “sandwich generation” women who care for older relatives require accessible and flexible health education, including Web-based approaches. Objective This paper describes the development and implementation of a Web-based health education intervention, The Sandwich Generation Diner, as a tool for intergenerational caregivers of older adults with physical and cognitive impairments. Methods We used Bartholomew’s Intervention Mapping (IM) process to develop our theory-based health education program. Bandura’s (1997) self-efficacy theory provided the overarching theoretical model. Results The Sandwich Generation Diner website features four modules that address specific health care concerns. Our research involves randomly assigning caregiver participants to one of two experimental conditions that are identical in the type of information provided, but vary significantly in the presentation. In addition to structured Web-based assessments, specific website usage data are recorded. Conclusions The Sandwich Generation Diner was developed to address some of the informational and self-efficacy needs of intergenerational female caregivers. The next step is to demonstrate that this intervention is: (1) attractive and effective with families assisting older adults, and (2) feasible to embed within routine home health services for older adults. PMID:27269632

  3. 4DCBCT-based motion modeling and 3D fluoroscopic image generation for lung cancer radiotherapy

    NASA Astrophysics Data System (ADS)

    Dhou, Salam; Hurwitz, Martina; Mishra, Pankaj; Berbeco, Ross; Lewis, John

    2015-03-01

    A method is developed to build patient-specific motion models based on 4DCBCT images taken at treatment time and use them to generate 3D time-varying images (referred to as 3D fluoroscopic images). Motion models are built by applying Principal Component Analysis (PCA) on the displacement vector fields (DVFs) estimated by performing deformable image registration on each phase of 4DCBCT relative to a reference phase. The resulting PCA coefficients are optimized iteratively by comparing 2D projections captured at treatment time with projections estimated using the motion model. The optimized coefficients are used to generate 3D fluoroscopic images. The method is evaluated using anthropomorphic physical and digital phantoms reproducing real patient trajectories. For physical phantom datasets, the average tumor localization error (TLE) and (95th percentile) in two datasets were 0.95 (2.2) mm. For digital phantoms assuming superior image quality of 4DCT and no anatomic or positioning disparities between 4DCT and treatment time, the average TLE and the image intensity error (IIE) in six datasets were smaller using 4DCT-based motion models. When simulating positioning disparities and tumor baseline shifts at treatment time compared to planning 4DCT, the average TLE (95th percentile) and IIE were 4.2 (5.4) mm and 0.15 using 4DCT-based models, while they were 1.2 (2.2) mm and 0.10 using 4DCBCT-based ones, respectively. 4DCBCT-based models were shown to perform better when there are positioning and tumor baseline shift uncertainties at treatment time. Thus, generating 3D fluoroscopic images based on 4DCBCT-based motion models can capture both inter- and intra- fraction anatomical changes during treatment.

  4. Generation and functional assessment of 3D multicellular spheroids in droplet based microfluidics platform.

    PubMed

    Sabhachandani, P; Motwani, V; Cohen, N; Sarkar, S; Torchilin, V; Konry, T

    2016-02-01

    Here we describe a robust, microfluidic technique to generate and analyze 3D tumor spheroids, which resembles tumor microenvironment and can be used as a more effective preclinical drug testing and screening model. Monodisperse cell-laden alginate droplets were generated in polydimethylsiloxane (PDMS) microfluidic devices that combine T-junction droplet generation and external gelation for spheroid formation. The proposed approach has the capability to incorporate multiple cell types. For the purposes of our study, we generated spheroids with breast cancer cell lines (MCF-7 drug sensitive and resistant) and co-culture spheroids of MCF-7 together with a fibroblast cell line (HS-5). The device has the capability to house 1000 spheroids on chip for drug screening and other functional analysis. Cellular viability of spheroids in the array part of the device was maintained for two weeks by continuous perfusion of complete media into the device. The functional performance of our 3D tumor models and a dose dependent response of standard chemotherapeutic drug, doxorubicin (Dox) and standard drug combination Dox and paclitaxel (PCT) was analyzed on our chip-based platform. Altogether, our work provides a simple and novel, in vitro platform to generate, image and analyze uniform, 3D monodisperse alginate hydrogel tumors for various omic studies and therapeutic efficiency screening, an important translational step before in vivo studies. PMID:26686985

  5. Refinements in an Mg/MgH2/H2O-Based Hydrogen Generator

    NASA Technical Reports Server (NTRS)

    Kindler, Andrew; Huang, Yuhong

    2010-01-01

    Some refinements have been conceived for a proposed apparatus that would generate hydrogen (for use in a fuel cell) by means of chemical reactions among magnesium, magnesium hydride, and steam. The refinements lie in tailoring spatial and temporal distributions of steam and liquid water so as to obtain greater overall energy-storage or energy-generation efficiency than would otherwise be possible. A description of the prior art is prerequisite to a meaningful description of the present refinements. The hydrogen-generating apparatus in question is one of two versions of what was called the "advanced hydrogen generator" in "Fuel-Cell Power Systems Incorporating Mg-Based H2 Generators" (NPO-43554), NASA Tech Briefs, Vol. 33, No. 1 (January 2009), page 52. To recapitulate: The apparatus would include a reactor vessel that would be initially charged with magnesium hydride. The apparatus would exploit two reactions: The endothermic decomposition reaction MgH2-->Mg + H2, which occurs at a temperature greater than or equal to 300 C, and The exothermic oxidation reaction MgH2 + H2O MgO + 2H2, which occurs at a temperature greater than or equal to 330 C.

  6. Performance characterization and optimization of microgrid-based energy generation and storage technologies

    NASA Astrophysics Data System (ADS)

    Guggenberger, Joe David, II

    Renewable energy-powered microgrids have proven to be a valuable technology for self-contained (off-grid) energy systems. Characterizing microgrid system performance pre-deployment would allow the system to be appropriately sized to meet all required electrical loads at a given renewable source operational time frequency. A vanadium redox battery was empirically characterized to determine operating efficiency as a function of charging characteristics and parasitic load losses. A model was developed to iteratively determine system performance based on known weather conditions and load requirements. A case study was performed to compare modeled system performance to measurements taken during operation of the microgrid system. Another iterative model was developed to incrementally predict the microgrid operating performance as a function of diesel generator operating frequency. Calibration of the model was performed to determine accurate PV panel and inverter efficiencies. A case study was performed to estimate the constant loads the system could power at varying diesel generator operating frequencies. Typical Meteorological Year 3 (TMY3) data from 217 Class I locations throughout the United States was inserted into the model to determine the quantity of external AC and DC load the system could supply at intermittent diesel generator variable operational frequencies. Ordinary block Kriging analysis was performed using ArcGIS to interpolate AC and DC load power between TMY3 Class I locations for each diesel generator operating frequency. Figures representing projected AC and DC external load were then developed for each diesel generator operating frequency.

  7. A blended polymer electret-based micro-electronic power generator

    NASA Astrophysics Data System (ADS)

    Ko, Wen-Ching; Lee, Bor-Shiun; Chen, Jia-Lun; Lin, Shun-Chi; Wu, Wen-Jong; Lee, Chih-Kung

    2008-03-01

    Recently, power harvesting technologies for low-power electronic devices have attracted much interest. In this paper, the design and fabrication methods of a micro-electrostatic power generator is presented. This power generator comprises a stator developed using an electret film for charge storage and a rotor covered by an interdigital electrode for electric power generation. The newly developed electret material is made from mixing two solutions. The first solution was made by blending polystyrene (PS) and cycloolefin copolymer (COC). The second solution was obtained by an additive process as polar molecule was added into COC. This unique two solution electret method can easily be integrated and adopted to the micro fabrication process. The charge storage capability of this new electret material was investigated and results showed that low concentration of polystyrene in the blended material will not only have more stable but also higher electrostatic charge than that of pure COC. In addition, the polar molecular additives also improve the electret properties of COC due to micro-cavities formation and the interactions between molecules and polymer. Our newly developed blended electret material has excellent mechanical properties and is easy to use when compared to using Teflon Fluorinated Ethylene Propylene (FEP) and polypropylene (PP). A feasibility study of a micro electrostatic power generator based on our blended electret material was performed. Experimental results demonstrate the feasibility and effectiveness of this new type of micro electrostatic power generator.

  8. Multistep Reaction Based De Novo Drug Design: Generating Synthetically Feasible Design Ideas.

    PubMed

    Masek, Brian B; Baker, David S; Dorfman, Roman J; DuBrucq, Karen; Francis, Victoria C; Nagy, Stephan; Richey, Bree L; Soltanshahi, Farhad

    2016-04-25

    We describe a "multistep reaction driven" evolutionary algorithm approach to de novo molecular design. Structures generated by the approach include a proposed synthesis path intended to aid the chemist in assessing the synthetic feasibility of the ideas that are generated. The methodology is independent of how the design ideas are scored, allowing multicriteria drug design to address multiple issues including activity at one or more pharmacological targets, selectivity, physical and ADME properties, and off target liabilities; the methods are compatible with common computer-aided drug discovery "scoring" methodologies such as 2D- and 3D-ligand similarity, docking, desirability functions based on physiochemical properties, and/or predictions from 2D/3D QSAR or machine learning models and combinations thereof to be used to guide design. We have performed experiments to assess the extent to which known drug space can be covered by our approach. Using a library of 88 generic reactions and a database of ∼20 000 reactants, we find that our methods can identify "close" analogs for ∼50% of the known small molecule drugs with molecular weight less than 300. To assess the quality of the in silico generated synthetic pathways, synthesis chemists were asked to rate the viability of synthesis pathways: both "real" and in silico generated. In silico reaction schemes generated by our methods were rated as very plausible with scores similar to known literature synthesis schemes. PMID:27031173

  9. Channel-Based Key Generation for Encrypted Body-Worn Wireless Sensor Networks.

    PubMed

    Van Torre, Patrick

    2016-01-01

    Body-worn sensor networks are important for rescue-workers, medical and many other applications. Sensitive data are often transmitted over such a network, motivating the need for encryption. Body-worn sensor networks are deployed in conditions where the wireless communication channel varies dramatically due to fading and shadowing, which is considered a disadvantage for communication. Interestingly, these channel variations can be employed to extract a common encryption key at both sides of the link. Legitimate users share a unique physical channel and the variations thereof provide data series on both sides of the link, with highly correlated values. An eavesdropper, however, does not share this physical channel and cannot extract the same information when intercepting the signals. This paper documents a practical wearable communication system implementing channel-based key generation, including an implementation and a measurement campaign comprising indoor as well as outdoor measurements. The results provide insight into the performance of channel-based key generation in realistic practical conditions. Employing a process known as key reconciliation, error free keys are generated in all tested scenarios. The key-generation system is computationally simple and therefore compatible with the low-power micro controllers and low-data rate transmissions commonly used in wireless sensor networks. PMID:27618051

  10. Bioinspired Multifunctional Paper-Based rGO Composites for Solar-Driven Clean Water Generation.

    PubMed

    Lou, Jinwei; Liu, Yang; Wang, Zhongyong; Zhao, Dengwu; Song, Chengyi; Wu, Jianbo; Dasgupta, Neil; Zhang, Wang; Zhang, Di; Tao, Peng; Shang, Wen; Deng, Tao

    2016-06-15

    Reusing polluted water through various decontamination techniques has appeared as one of the most practical approaches to address the global shortage of clean water. Rather than relying on single decontamination mechanism, herein we report the preparation and utilization of paper-based composites for multifunctional solar-driven clean water generation that is inspired by the multiple water purification approaches in biological systems. The reduced graphene oxide (rGO) sheets within such composites can efficiently remove organic contaminants through physical adsorption mechanism. Under solar irradiation, the floating rGO composites can instantly generate localized heating, which not only can directly generate clean water through distillation mechanism but also significantly enhance adsorption removal performance with the assistance of upward vapor flow. Such porous-structured paper-based composites allow for facile incorporation of photocatalysts to regenerate clean water out of contaminated water with combined adsorption, photodegradation, and interfacial heat-assisted distillation mechanisms. Within a homemade all-in-one water treatment device, the practical applicability of the composites for multifunctional clean water generation has been demonstrated. PMID:27228106

  11. Optimization of disk generator performance for base-load power plant systems applications

    SciTech Connect

    Teare, J.D.; Loubsky, W.J.; Lytle, J.K.; Louis, J.F.

    1980-01-01

    Disk generators for use in base-load MHD power plants are examined for both open-cycle and closed-cycle operating modes. The OCD cases are compared with PSPEC results for a linear channel; enthalpy extractions up to 23% with 71% isentropic efficiency are achievable with generator inlet conditions similar to those used in PSPEC, thus confirming that the disk configuration is a viable alternative for base-load power generation. The evaluation of closed-cycle disks includes use of a simplified cycle model. High system efficiencies over a wide range of power levels are obtained for effective Hall coefficients in the range 2.3 to 4.9. Cases with higher turbulence (implying ..beta../sub eff/ less than or equal to 2.4) yield high system efficiencies at power levels of 100 to 500 MW/sub e/. All these CCD cases compare favorably with linear channels reported in the GE ECAS study, yielding higher isentropic efficiences for a given enthalpy extraction. Power densities in the range 70 to 170 MW/m/sup 3/ appear feasible, leading to very compact generator configurations.

  12. 68Ga-PET radiopharmacy: A generator-based alternative to 18F-radiopharmacy.

    PubMed

    Maecke, H R; André, J P

    2007-01-01

    Positron emission tomography (PET) is becoming a dominating method in the field of molecular imaging. Most commonly used radionuclides are accelerator produced 11C and 18F. An alternative method to label biomolecules is the use of metallic positron emitters; among them 68Ga is the most promising as it can be produced from a generator system consisting of an inorganic or organic matrix immobilizing the parent radionuclide 68Ge. Germanium-68 has a long half-life of 271 days which allows the production of long-lived, potentially very cost-effective generator systems. A commercial generator from Obninsk, Russia, is available which uses TiO2 as an inorganic matrix to immobilize 68Ge in the oxidation state IV+. 68Ge(IV) is chemically sufficiently different to allow efficient separation from 68Ga(III). Ga3+ is redox-inert; its coordination chemistry is dominated by its hard acid character. A variety of mono- and bifunctional chelators were developed which allow immobilization of 68Ga3+ and convenient coupling to biomolecules. Especially peptides targeting G-protein coupled receptors overexpressed on human tumour cells have been studied preclinically and in patient studies showing high and specific tumour uptake and specific localization. 68Ga-radiopharmacy may indeed be an alternative to 18F-based radiopharmacy. Freeze-dried, kit-formulated precursors along with the generator may be provided, similar to the 99Mo/99mTc-based radiopharmacy, still the mainstay of nuclear medicine. PMID:17172157

  13. [The measurement of water vapor isotope based on mid-infrared difference frequency generation].

    PubMed

    Wang, Zhu-Qing; Wang, Huan P; Cao, Zhen-Song; Yuan, Yi-Qian; Zhang, Wei-Jun; Gong, Zhi-Ben; Gao, Xiao-Ming

    2009-12-01

    Stable-isotope ratio analysis of water is an important tool for geology, meteorology, and earth sciences. Measurements of water vapor isotopes are very helpful to explaining stratospheric aridity and related issues in atmospheric sciences. The absorption of water vapor near 2.7 microm is very strong so it is suitable for measuring high sensitivity spectra. Based on difference frequency generation and quasi-phase matching, by mixing an Nd : YAG laser with Ti : Sapphire tunable from 750 to 840 nm in a 50 mm long periodically poled lithium niobate (PPLN) crystal, a widely tunable CW laser source was generated for the mid-infrared spectral range from 2.5 to 4 microm. We chose lambda = 20 microm for PPLN crystal, the generated laser was around 2.7 microm. This laser is widely tunable and of inherent narrow linewidth based on difference-frequency generation. Using this idler laser and 100 m multi-pass cell, and direct absorption the water vapor isotopes were measured in the laboratory air. The authors measured isotopes ratios and delta17O, delta18O and deltaD. The values were found to be in excellent agreement with the standard value for three individual lines. PMID:20210148

  14. Quantum cryptography for WDM networks: Encryption with coherent states and key generation with fiber based entanglement

    NASA Astrophysics Data System (ADS)

    Liang, Chuang

    New telecommunication techniques utilizing distinctive quantum properties, e.g., measurement uncertainties and entanglement, extend the capabilities of existing systems. Quantum cryptography, as an example, provides physical layer security enforced by fundamental physical laws, while modern cryptographic techniques rely on assumptions of intractability of certain mathematical problems with limited computational power. Rapid growth of the Internet leading to global telecommunications puts heavy demands on information security. A novel keyed direct data encryption technique based on the fundamental and irreducible quantum noise of laser light is shown to be compatible with the existing high-speed optical communications infrastructure. With this technique, line encryption for OC-12 (622 Mbps) SONET data over 250 km in a wavelength-division-multiplexing network is demonstrated with fully streaming data. Nonlocal correlation is employed in applications including cryptographic key generation whose practical realizations require telecom-band photon counting and entangled photon-pair generation. Existing telecom-band avalanche-photodiode based photon-counting techniques suffer from large detection noise at high operation rates. New techniques such as ultrashort gating and synchronous sampling at the onset of avalanches are introduced for suppressing the detection noise at high operation speeds. Photon counting at record speeds (25 MHz) that employing an avalanche photodiode is developed, demonstrated and deployed in the experimental studies. Telecom-band correlated photons can be directly created inside optical fibers through its chi(3) nonlinearity. This technique brings practical advantages such as the easy compatibility with fiber-optic systems, excellent spatial modal purity, and potential high-speed operation. As a practical development of this technique, a novel Faraday-mirror based ultra-stable scheme for generating polarization entangled photon-pairs is proposed

  15. Pipe crack identification based on finite element method of second generation wavelets

    NASA Astrophysics Data System (ADS)

    Ye, Junjie; He, Yumin; Chen, Xuefeng; Zhai, Zhi; Wang, Youming; He, Zhengjia

    2010-02-01

    In this paper, a new method is presented to identify crack location and size, which is based on stress intensity factor suitable for pipe structure and finite element method of second generation wavelets (SGW-FEM). Pipe structure is dispersed into a series of nested thin-walled pipes. By making use of stress intensity factor of the thin-walled pipe, a new calculation method of crack equivalent stiffness is proposed to solve the stress intensity factor of the pipe structure. On this basis, finite element method of second generation wavelets is used to establish the dynamic model of cracked pipe. Then we combine forward problem with inverse problem in order to establish quantitative identification method of the crack based on frequency change, which provides a non-destructive testing technology with vibration for the pipe structure. The efficiency of the proposed method is verified by experiments.

  16. A parallel multiple path tracing method based on OptiX for infrared image generation

    NASA Astrophysics Data System (ADS)

    Wang, Hao; Wang, Xia; Liu, Li; Long, Teng; Wu, Zimu

    2015-12-01

    Infrared image generation technology is being widely used in infrared imaging system performance evaluation, battlefield environment simulation and military personnel training, which require a more physically accurate and efficient method for infrared scene simulation. A parallel multiple path tracing method based on OptiX was proposed to solve the problem, which can not only increase computational efficiency compared to serial ray tracing using CPU, but also produce relatively accurate results. First, the flaws of current ray tracing methods in infrared simulation were analyzed and thus a multiple path tracing method based on OptiX was developed. Furthermore, the Monte Carlo integration was employed to solve the radiation transfer equation, in which the importance sampling method was applied to accelerate the integral convergent rate. After that, the framework of the simulation platform and its sensor effects simulation diagram were given. Finally, the results showed that the method could generate relatively accurate radiation images if a precise importance sampling method was available.

  17. Image communication scheme based on dynamic visual cryptography and computer generated holography

    NASA Astrophysics Data System (ADS)

    Palevicius, Paulius; Ragulskis, Minvydas

    2015-01-01

    Computer generated holograms are often exploited to implement optical encryption schemes. This paper proposes the integration of dynamic visual cryptography (an optical technique based on the interplay of visual cryptography and time-averaging geometric moiré) with Gerchberg-Saxton algorithm. A stochastic moiré grating is used to embed the secret into a single cover image. The secret can be visually decoded by a naked eye if only the amplitude of harmonic oscillations corresponds to an accurately preselected value. The proposed visual image encryption scheme is based on computer generated holography, optical time-averaging moiré and principles of dynamic visual cryptography. Dynamic visual cryptography is used both for the initial encryption of the secret image and for the final decryption. Phase data of the encrypted image are computed by using Gerchberg-Saxton algorithm. The optical image is decrypted using the computationally reconstructed field of amplitudes.

  18. Nanoparticle based insulin delivery system: the next generation efficient therapy for Type 1 diabetes.

    PubMed

    Sharma, Garima; Sharma, Ashish Ranjan; Nam, Ju-Suk; Doss, George Priya C; Lee, Sang-Soo; Chakraborty, Chiranjib

    2015-01-01

    Diabetic cases have increased rapidly in recent years throughout the world. Currently, for type-1 diabetes mellitus (T1DM), multiple daily insulin (MDI) injections is the most popular treatment throughout the world. At this juncture, researchers are trying to develop different insulin delivery systems, especially through oral and pulmonary route using nanocarrier based delivery system. This next generation efficient therapy for T1DM may help to improve the quality of life of diabetic patients who routinely employ insulin by the subcutaneous route. In this paper, we have depicted various next generation nanocarrier based insulin delivery systems such as chitosan-insulin nanoparticles, PLGA-insulin nanoparticles, dextran-insulin nanoparticles, polyalkylcyanoacrylated-insulin nanoparticles and solid lipid-insulin nanoparticles. Modulation of these insulin nanocarriers may lead to successful oral or pulmonary insulin nanoformulations in future clinical settings. Therefore, applications and limitations of these nanoparticles in delivering insulin to the targeted site have been thoroughly discussed. PMID:26498972

  19. A field-emission based vacuum device for the generation of THz waves

    NASA Astrophysics Data System (ADS)

    Lin, Ming-Chieh

    2005-03-01

    Terahertz waves have been used to characterize the electronic, vibrational and compositional properties of solid, liquid and gas phase materials during the past decade. More and more applications in imaging science and technology call for the well development of THz wave sources. Amplification and generation of a high frequency electromagnetic wave are a common interest of field emission based devices. In the present work, we propose a vacuum electronic device based on field emission mechanism for the generation of THz waves. To verify our thinking and designs, the cold tests and the hot tests have been studied via the simulation tools, SUPERFISH and MAGIC. In the hot tests, two types of electron emission mechanisms are considered. One is the field emission and the other is the explosive emission. The preliminary design of the device is carried out and tested by the numerical simulations. The simulation results show that an electronic efficiency up to 4% can be achieved without employing any magnetic circuits.

  20. Enhancing Automatic Biological Pathway Generation with GO-based Gene Similarity

    SciTech Connect

    Sanfilippo, Antonio P.; Baddeley, Robert L.; Beagley, Nathaniel; Riensche, Roderick M.; Gopalan, Banu

    2009-08-03

    One of the greatest challenges in today’s analysis of microarray gene expression data is to identify pathways across regulated genes that underlie structural and functional changes of living cells in specific pathologies. Most current approaches to pathway generation are based on a reverse engineering approach in which pathway plausibility is solely induced from observed pathway data. These approaches tend to lack in generality as they are too dependent on the pathway observables from which they are induced. By contrast, alternative approaches that rely on prior biological knowledge may err in the opposite direction as the prior knowledge is usually not sufficiently tuned to the pathology of focus. In this paper, we present a novel pathway generation approach which combines insights from the reverse engineering and knowledge-based approaches to increase the biological plausibility and specificity of induced regulatory networks.

  1. Nonlinear dispersion-based incoherent photonic processing for microwave pulse generation with full reconfigurability.

    PubMed

    Bolea, Mario; Mora, José; Ortega, Beatriz; Capmany, José

    2012-03-12

    A novel all-optical technique based on the incoherent processing of optical signals using high-order dispersive elements is analyzed for microwave arbitrary pulse generation. We show an approach which allows a full reconfigurability of a pulse in terms of chirp, envelope and central frequency by the proper control of the second-order dispersion and the incoherent optical source power distribution, achieving large values of time-bandwidth product. PMID:22418557

  2. Two-dimensionally tunable microwave signal generation based on optical frequency-to-time conversion.

    PubMed

    Ye, Jia; Yan, Lianshen; Pan, Wei; Luo, Bin; Zou, Xihua; Yi, Anlin; Yao, Xiaotian Steve

    2010-08-01

    We propose and experimentally demonstrate an all-fiber-based approach to generate microwave signals with tunable frequency and pulse width. The adjustable optical power spectrum can be achieved using a spectrum shaper, consisting of a variable differential-group-delay element and a bandwidth-tunable optical filter. Through the frequency-to-time conversion in the dispersive fiber, the frequency and pulse width of the obtained microwave signals can be user defined by modifying the optical spectrum shape. PMID:20680073

  3. Truly random bit generation based on a novel random Brillouin fiber laser.

    PubMed

    Xiang, Dao; Lu, Ping; Xu, Yanping; Gao, Song; Chen, Liang; Bao, Xiaoyi

    2015-11-15

    We propose a novel dual-emission random Brillouin fiber laser (RBFL) with bidirectional pumping operation. Numerical simulations and experimental verification of the chaotic temporal and statistical properties of the RBFL are conducted, revealing intrinsic unpredictable intensity fluctuations and two completely uncorrelated laser outputs. A random bit generator based on quantum noise sources in the random Fabry-Perot resonator of the RBFL is realized at a bit rate of 5 Mbps with verified randomness. PMID:26565888

  4. Selenia: A habitability study for the development of a third generation lunar base

    NASA Technical Reports Server (NTRS)

    1991-01-01

    When Apollo astronauts landed on the Moon, the first generation of lunar bases was established. They consisted essentially of a lunar module and related hardware capable of housing two astronauts for not more than several days. Second generation lunar bases are being developed, and further infrastructure, such as space station, orbital transfer, and reusable lander vehicles will be necessary, as prolonged stay on the Moon is required for exploration, research, and construction for the establishment of a permanent human settlement there. Human life in these habitats could be sustained for months, dependent on a continual flow of life-support supplies from Earth. Third-generation lunar bases will come into being as self sufficiency of human settlements becomes feasible. Regeneration of water, oxygen production, and development of indigenous construction materials from lunar resources will be necessary. Greenhouses will grow food supplies in engineered biospheres. Assured protection from solar flares and cosmic radiation must be provided, as well as provision for survival under meteor showers, or the threat of meteorite impact. All these seem to be possible within the second decade of the next century. Thus, the builders of Selenia, the first of the third-generation lunar bases are born today. During the last two years students from the School of Architecture of the University of Puerto Rico have studied the problems that relate to habitability for prolonged stay in extraterrestrial space. An orbital personnel transport to Mars developed originally by the Aerospace Engineering Department of the University of Michigan was investigated and habitability criteria for evaluation of human space habitats were proposed. An important finding from that study was that the necessary rotational diameter of the vessel has to be on the order of two kilometers to ensure comfort for humans under the artificial gravity conditions necessary to maintain physiological well being of

  5. The role of optimization in the next generation of computer-based design tools

    NASA Technical Reports Server (NTRS)

    Rogan, J. Edward

    1989-01-01

    There is a close relationship between design optimization and the emerging new generation of computer-based tools for engineering design. With some notable exceptions, the development of these new tools has not taken full advantage of recent advances in numerical design optimization theory and practice. Recent work in the field of design process architecture has included an assessment of the impact of next-generation computer-based design tools on the design process. These results are summarized, and insights into the role of optimization in a design process based on these next-generation tools are presented. An example problem has been worked out to illustrate the application of this technique. The example problem - layout of an aircraft main landing gear - is one that is simple enough to be solved by many other techniques. Although the mathematical relationships describing the objective function and constraints for the landing gear layout problem can be written explicitly and are quite straightforward, an approximation technique has been used in the solution of this problem that can just as easily be applied to integrate supportability or producibility assessments using theory of measurement techniques into the design decision-making process.

  6. Potential Occupational Exposures and Health Risks Associated with Biomass-Based Power Generation

    PubMed Central

    Rohr, Annette C.; Campleman, Sharan L.; Long, Christopher M.; Peterson, Michael K.; Weatherstone, Susan; Quick, Will; Lewis, Ari

    2015-01-01

    Biomass is increasingly being used for power generation; however, assessment of potential occupational health and safety (OH&S) concerns related to usage of biomass fuels in combustion-based generation remains limited. We reviewed the available literature on known and potential OH&S issues associated with biomass-based fuel usage for electricity generation at the utility scale. We considered three potential exposure scenarios—pre-combustion exposure to material associated with the fuel, exposure to combustion products, and post-combustion exposure to ash and residues. Testing of dust, fungal and bacterial levels at two power stations was also undertaken. Results indicated that dust concentrations within biomass plants can be extremely variable, with peak levels in some areas exceeding occupational exposure limits for wood dust and general inhalable dust. Fungal spore types, identified as common environmental species, were higher than in outdoor air. Our review suggests that pre-combustion risks, including bioaerosols and biogenic organics, should be considered further. Combustion and post-combustion risks appear similar to current fossil-based combustion. In light of limited available information, additional studies at power plants utilizing a variety of technologies and biomass fuels are recommended. PMID:26206568

  7. An ICF system based on Z-pinch radiation produced by an explosive magnetic generator

    NASA Astrophysics Data System (ADS)

    Garanin, S. G.; Ivanovsky, A. V.; Mkhitariyan, L. S.

    2011-10-01

    It is known that a thermonuclear target can be ignited by an implosion accomplished with X-radiation generated by means of laser radiation conversion or by a Z pinch formed by a high-power current pulse. For these purposes laser facility NIF has been constructed in the USA, 'Megajoule' is being constructed in France and there is a project of laser facility UFL in Russia. The project of stationary facility X has been developed in SNL USA to produce a Z pinch capable of generating an x-ray pulse with parameters close to the ignition threshold. There is a great chance, however, that the already tested technologies, including disc explosive magnetic generators (DEMG), systems of current peaking based on electrically exploded foil opening switches and high-voltage switching devices, allow the intriguing problem of the ignition feasibility to be solved and the quickest and cheapest way to accomplish this to be provided. To explore this possibility, the paper will sequentially analyse the ignition conditions. The required parameters of Z pinch X-radiation and the size of the DEMG-based facility to obtain these parameters will be evaluated. Capabilities of the new current sources based on the DEMG and of the devices shaping a current pulse will be presented and compared with those required for the ignition.

  8. A novel Ray-space based view generation algorithm via Radon transform

    NASA Astrophysics Data System (ADS)

    Xu, Lingfeng; Hou, Ling; Au, Oscar C.; Sun, Wenxiu; Zhang, Xingyu; Guo, Yuanfang

    2013-06-01

    Ray-space interpolation is one of the key technologies to generate virtual viewpoint images, typically in epipolar plane images (EPI), to realize free viewpoint television (FTV). In this paper, a novel Radon transform based ray-space interpolation algorithm (RTI) is proposed to generate virtual viewpoint images in the EPI. In the proposed RTI, feature points of each EPI are first extracted to form the corresponding feature epipolar plane image (FEPI). Radon transform is then applied to each FEPI to detect the candidate interpolation direction set. Then corresponding pixels in neighboring real view rows for each pixel to be interpolated are found by some block matching based interpolation method, in which the smoothness property of the disparity field and the correlation among neighboring EPIs are explored. Possible occlusion regions are processed by the proposed one-sided interpolation. Finally, to solve the problem that the cameras are not equally spaced, a novel ray-space based spacing correction algorithm is proposed to correct the EPI such that pixels corresponding to the same scene point will form a straight line. Experimental results suggest that the proposed RTI and the spacing correction algorithm can achieve good performance. Moreover, compare with traditional methods, our proposed algorithm can generate good interpolation result even if apriori depth range is not known. [Figure not available: see fulltext.

  9. Potential Occupational Exposures and Health Risks Associated with Biomass-Based Power Generation.

    PubMed

    Rohr, Annette C; Campleman, Sharan L; Long, Christopher M; Peterson, Michael K; Weatherstone, Susan; Quick, Will; Lewis, Ari

    2015-07-01

    Biomass is increasingly being used for power generation; however, assessment of potential occupational health and safety (OH&S) concerns related to usage of biomass fuels in combustion-based generation remains limited. We reviewed the available literature on known and potential OH&S issues associated with biomass-based fuel usage for electricity generation at the utility scale. We considered three potential exposure scenarios--pre-combustion exposure to material associated with the fuel, exposure to combustion products, and post-combustion exposure to ash and residues. Testing of dust, fungal and bacterial levels at two power stations was also undertaken. Results indicated that dust concentrations within biomass plants can be extremely variable, with peak levels in some areas exceeding occupational exposure limits for wood dust and general inhalable dust. Fungal spore types, identified as common environmental species, were higher than in outdoor air. Our review suggests that pre-combustion risks, including bioaerosols and biogenic organics, should be considered further. Combustion and post-combustion risks appear similar to current fossil-based combustion. In light of limited available information, additional studies at power plants utilizing a variety of technologies and biomass fuels are recommended. PMID:26206568

  10. Development of Decision Model for Selection of Appropriate Power Generation System Using Distance Based Approach Method

    NASA Astrophysics Data System (ADS)

    Widiyanto, Anugerah; Kato, Seizo; Maruyama, Naoki

    For solving decision problems in electric generation planning, a matrix operation based deterministic quantitative model called the Distance Based Approach (DBA) has been proposed for comparing the technical-economical and environmental features of various electric power plants. The customized computer code is developed to evaluate the overall function of alternative energy systems from the performance pattern corresponding to the selected energy attributes. For the purpose of exploring the applicability and the effectiveness of the proposed model, the model is applied to decision problems concerning the selection of energy sources for power generation in Japan. The set of nine energy alternatives includes conventional and new energy technologies of oil fired-, natural gas fired-, coal fired-, nuclear power, hydropower, geothermal, solar photovoltaic, wind power and solar thermal plants. Also, a set of criteria for optimized selection includes five areas of concern; energy economy, energy security, environmental protection, socio-economic development and technological aspects for electric power generation. The result will be a ranking of alternative sources of energy based on the Euclidean composite distance of each alternative to the designated optimal source of energy.

  11. Parallel octree-based hexahedral mesh generation for eulerian to lagrangian conversion.

    SciTech Connect

    Staten, Matthew L.; Owen, Steven James

    2010-09-01

    Computational simulation must often be performed on domains where materials are represented as scalar quantities or volume fractions at cell centers of an octree-based grid. Common examples include bio-medical, geotechnical or shock physics calculations where interface boundaries are represented only as discrete statistical approximations. In this work, we introduce new methods for generating Lagrangian computational meshes from Eulerian-based data. We focus specifically on shock physics problems that are relevant to ASC codes such as CTH and Alegra. New procedures for generating all-hexahedral finite element meshes from volume fraction data are introduced. A new primal-contouring approach is introduced for defining a geometric domain. New methods for refinement, node smoothing, resolving non-manifold conditions and defining geometry are also introduced as well as an extension of the algorithm to handle tetrahedral meshes. We also describe new scalable MPI-based implementations of these procedures. We describe a new software module, Sculptor, which has been developed for use as an embedded component of CTH. We also describe its interface and its use within the mesh generation code, CUBIT. Several examples are shown to illustrate the capabilities of Sculptor.

  12. Autonomously Generating Operations Sequences for a Mars Rover Using Artificial Intelligence-Based Planning

    NASA Astrophysics Data System (ADS)

    Sherwood, R.; Mutz, D.; Estlin, T.; Chien, S.; Backes, P.; Norris, J.; Tran, D.; Cooper, B.; Rabideau, G.; Mishkin, A.; Maxwell, S.

    2001-07-01

    This article discusses a proof-of-concept prototype for ground-based automatic generation of validated rover command sequences from high-level science and engineering activities. This prototype is based on ASPEN, the Automated Scheduling and Planning Environment. This artificial intelligence (AI)-based planning and scheduling system will automatically generate a command sequence that will execute within resource constraints and satisfy flight rules. An automated planning and scheduling system encodes rover design knowledge and uses search and reasoning techniques to automatically generate low-level command sequences while respecting rover operability constraints, science and engineering preferences, environmental predictions, and also adhering to hard temporal constraints. This prototype planning system has been field-tested using the Rocky 7 rover at JPL and will be field-tested on more complex rovers to prove its effectiveness before transferring the technology to flight operations for an upcoming NASA mission. Enabling goal-driven commanding of planetary rovers greatly reduces the requirements for highly skilled rover engineering personnel. This in turn greatly reduces mission operations costs. In addition, goal-driven commanding permits a faster response to changes in rover state (e.g., faults) or science discoveries by removing the time-consuming manual sequence validation process, allowing rapid "what-if" analyses, and thus reducing overall cycle times.

  13. Oscillating-water-column wave-energy-converter based on dielectric elastomer generator

    NASA Astrophysics Data System (ADS)

    Vertechy, R.; Fontana, M.; Rosati Papini, G. P.; Bergamasco, M.

    2013-04-01

    Dielectric Elastomers (DE) have been largely studied as actuators and sensors. Fewer researches have addressed their application in the field of energy harvesting. Their light weightiness, low cost, high corrosion resistance, and their intrinsic high-voltage and cyclical-way of operation make DE suited for harvesting mechanical energy from sea waves. To date, the development of cost-effective Wave Energy Converters (WECs) is hindered by inherent limitations of available material technologies. State of the art WECs are indeed based on traditional mechanical components, hydraulic transmissions and electromagnetic generators, which are all made by stiff, bulky, heavy and costly metallic materials. As a consequence, existing WECs result in being expensive, difficult to assemble, sensitive to corrosion and hard to maintain in the marine environment. DE generators could be an enabling technology for overcoming the intrinsic limitations of current WEC technologies. In this context, this paper focuses on Polymer-based Oscillating-Water-Column (Poly-OWC) type WECs, and analyzes the viability of using DE generators as power-take-off systems. Regarding paper structure, the first sections introduce the working principle of OWC devices and discuss possible layouts for their DE-based power-take-off system. Then, a simplified hydraulic-electro-hyperelastic model of a two-dimensional Poly-OWC is described. Finally, preliminary simulation results are shown which provide insights on the potential capabilities of Poly-OWC.

  14. Travel-time correction surface generation for the DOE Knowledge Base

    SciTech Connect

    Hipp, J.; Young, C.; Keyser, R.

    1997-08-01

    The DOE Knowledge Base data storage and access model consists of three parts: raw data processing, intermediate surface generation, and final output surface interpolation. The paper concentrates on the second step, surface generation, specifically applied to travel-time correction data. The surface generation for the intermediate step is accomplished using a modified kriging solution that provides robust error estimates for each for each interpolated point and satisfies many important physical requirements including differing quality data points, user-definable range of influence for each point, blend to background values for both interpolated values and error estimates beyond the ranges, and the ability to account for the effects of geologic region boundaries. These requirements are outlined and discussed and are linked to requirements specified for the final output model in the DOE Knowledge Base. Future work will focus on testing the entire Knowledge Base model using the regional calibration data sets which are being gathered by researchers at Los Alamos and Lawrence Livermore National Laboratories.

  15. The Role of Semantics in Next-Generation Online Virtual World-Based Retail Store

    NASA Astrophysics Data System (ADS)

    Sharma, Geetika; Anantaram, C.; Ghosh, Hiranmay

    Online virtual environments are increasingly becoming popular for entrepreneurship. While interactions are primarily between avatars, some interactions could occur through intelligent chatbots. Such interactions require connecting to backend business applications to obtain information, carry out real-world transactions etc. In this paper, we focus on integrating business application systems with virtual worlds. We discuss the probable features of a next-generation online virtual world-based retail store and the technologies involved in realizing the features of such a store. In particular, we examine the role of semantics in integrating popular virtual worlds with business applications to provide natural language based interactions.

  16. Electron density guided fragment-based drug design--a lead generation example.

    PubMed

    Abad, Marta C; Gibbs, Alan C; Zhang, Xuqing

    2011-01-01

    We describe here a method using protein crystallography as the sole detection tool for fragment-based lead discovery. The methodology consists of iterative design, synthesis, and X-ray crystallographic screening of three libraries of compounds. Target-specific compound design, by way of active site electron density in the presence of a bound fragment hit and the intentional lack of solution activity bias form the basis of our approach. We provide an example of this alternative fragment-based drug design (FBDD) method, detailing results from a campaign using ketohexokinase to generate a unique lead series with promising drug-like properties. PMID:21371603

  17. PDM-16QAM vector signal generation and detection based on intensity modulation and direct detection

    NASA Astrophysics Data System (ADS)

    Chen, Long; Yu, Jianjun; Li, Xinying

    2016-07-01

    We experimentally demonstrate a novel and simple method to generate and detect high speed polarization-division-multiplexing 16-ary quadrature-amplitude-modulation (PDM-16QAM) vector signal enabled by Mach-Zehnder modulator-based (MZM-based) optical-carrier-suppression (OCS) intensity modulation and direct detection. Due to the adoption of OCS intensity modulation, carrier beating can be avoided at the receiver, and thus polarization de-multiplexing can be implemented by digital-signal-processing-based (DSP-based) cascaded multi-modulus algorithm (CMMA) equalization instead of a polarization tracking system. The change of both amplitude and phase information due to the adoption of OCS modulation can be equalized by DSP-based amplitude and phase precoding at the transmitter. Up to 64-Gb/s PDM-16QAM vector signal is generated and detected after 2-km single-mode fiber-28 (SMF-28) or 20-km large-effective-area fiber (LEAF) transmission with a bit-error-ratio (BER) less than the hard-decision forward-error-correction (HD-FEC) threshold of 3.8×10-3.

  18. Energy-Efficient Next-Generation Passive Optical Networks Based on Sleep Mode and Heuristic Optimization

    NASA Astrophysics Data System (ADS)

    Zulai, Luis G. T.; Durand, Fábio R.; Abrão, Taufik

    2015-05-01

    In this article, an energy-efficiency mechanism for next-generation passive optical networks is investigated through heuristic particle swarm optimization. Ten-gigabit Ethernet-wavelength division multiplexing optical code division multiplexing-passive optical network next-generation passive optical networks are based on the use of a legacy 10-gigabit Ethernet-passive optical network with the advantage of using only an en/decoder pair of optical code division multiplexing technology, thus eliminating the en/decoder at each optical network unit. The proposed joint mechanism is based on the sleep-mode power-saving scheme for a 10-gigabit Ethernet-passive optical network, combined with a power control procedure aiming to adjust the transmitted power of the active optical network units while maximizing the overall energy-efficiency network. The particle swarm optimization based power control algorithm establishes the optimal transmitted power in each optical network unit according to the network pre-defined quality of service requirements. The objective is controlling the power consumption of the optical network unit according to the traffic demand by adjusting its transmitter power in an attempt to maximize the number of transmitted bits with minimum energy consumption, achieving maximal system energy efficiency. Numerical results have revealed that it is possible to save 75% of energy consumption with the proposed particle swarm optimization based sleep-mode energy-efficiency mechanism compared to 55% energy savings when just a sleeping-mode-based mechanism is deployed.

  19. Next-generation libraries for robust RNA interference-based genome-wide screens

    PubMed Central

    Kampmann, Martin; Horlbeck, Max A.; Chen, Yuwen; Tsai, Jordan C.; Bassik, Michael C.; Gilbert, Luke A.; Villalta, Jacqueline E.; Kwon, S. Chul; Chang, Hyeshik; Kim, V. Narry; Weissman, Jonathan S.

    2015-01-01

    Genetic screening based on loss-of-function phenotypes is a powerful discovery tool in biology. Although the recent development of clustered regularly interspaced short palindromic repeats (CRISPR)-based screening approaches in mammalian cell culture has enormous potential, RNA interference (RNAi)-based screening remains the method of choice in several biological contexts. We previously demonstrated that ultracomplex pooled short-hairpin RNA (shRNA) libraries can largely overcome the problem of RNAi off-target effects in genome-wide screens. Here, we systematically optimize several aspects of our shRNA library, including the promoter and microRNA context for shRNA expression, selection of guide strands, and features relevant for postscreen sample preparation for deep sequencing. We present next-generation high-complexity libraries targeting human and mouse protein-coding genes, which we grouped into 12 sublibraries based on biological function. A pilot screen suggests that our next-generation RNAi library performs comparably to current CRISPR interference (CRISPRi)-based approaches and can yield complementary results with high sensitivity and high specificity. PMID:26080438

  20. Automatic two- and three-dimensional mesh generation based on fuzzy knowledge processing

    NASA Astrophysics Data System (ADS)

    Yagawa, G.; Yoshimura, S.; Soneda, N.; Nakao, K.

    1992-09-01

    This paper describes the development of a novel automatic FEM mesh generation algorithm based on the fuzzy knowledge processing technique. A number of local nodal patterns are stored in a nodal pattern database of the mesh generation system. These nodal patterns are determined a priori based on certain theories or past experience of experts of FEM analyses. For example, such human experts can determine certain nodal patterns suitable for stress concentration analyses of cracks, corners, holes and so on. Each nodal pattern possesses a membership function and a procedure of node placement according to this function. In the cases of the nodal patterns for stress concentration regions, the membership function which is utilized in the fuzzy knowledge processing has two meanings, i.e. the “closeness” of nodal location to each stress concentration field as well as “nodal density”. This is attributed to the fact that a denser nodal pattern is required near a stress concentration field. What a user has to do in a practical mesh generation process are to choose several local nodal patterns properly and to designate the maximum nodal density of each pattern. After those simple operations by the user, the system places the chosen nodal patterns automatically in an analysis domain and on its boundary, and connects them smoothly by the fuzzy knowledge processing technique. Then triangular or tetrahedral elements are generated by means of the advancing front method. The key issue of the present algorithm is an easy control of complex two- or three-dimensional nodal density distribution by means of the fuzzy knowledge processing technique. To demonstrate fundamental performances of the present algorithm, a prototype system was constructed with one of object-oriented languages, Smalltalk-80 on a 32-bit microcomputer, Macintosh II. The mesh generation of several two- and three-dimensional domains with cracks, holes and junctions was presented as examples.

  1. Atlas-Based Automatic Generation of Subject-Specific Finite Element Tongue Meshes.

    PubMed

    Bijar, Ahmad; Rohan, Pierre-Yves; Perrier, Pascal; Payan, Yohan

    2016-01-01

    Generation of subject-specific 3D finite element (FE) models requires the processing of numerous medical images in order to precisely extract geometrical information about subject-specific anatomy. This processing remains extremely challenging. To overcome this difficulty, we present an automatic atlas-based method that generates subject-specific FE meshes via a 3D registration guided by Magnetic Resonance images. The method extracts a 3D transformation by registering the atlas' volume image to the subject's one, and establishes a one-to-one correspondence between the two volumes. The 3D transformation field deforms the atlas' mesh to generate the subject-specific FE mesh. To preserve the quality of the subject-specific mesh, a diffeomorphic non-rigid registration based on B-spline free-form deformations is used, which guarantees a non-folding and one-to-one transformation. Two evaluations of the method are provided. First, a publicly available CT-database is used to assess the capability to accurately capture the complexity of each subject-specific Lung's geometry. Second, FE tongue meshes are generated for two healthy volunteers and two patients suffering from tongue cancer using MR images. It is shown that the method generates an appropriate representation of the subject-specific geometry while preserving the quality of the FE meshes for subsequent FE analysis. To demonstrate the importance of our method in a clinical context, a subject-specific mesh is used to simulate tongue's biomechanical response to the activation of an important tongue muscle, before and after cancer surgery. PMID:26577253

  2. Scalable and reconfigurable generation of flat optical comb for WDM-based next-generation broadband optical access networks

    NASA Astrophysics Data System (ADS)

    Chen, Chen; Zhang, Chongfu; Zhang, Wei; Jin, Wei; Qiu, Kun

    2014-06-01

    A tunable comb generator (TCG) by cascading a single phase modulator (PM) with two identical intensity modulators (IMs) is proposed for the scalable and reconfigurable generation of flat optical comb. Detailed theoretical analysis is performed to find out the optimized condition for flat optical comb generation using the proposed TCG and the scalability of the generated optical comb is also analyzed under the optimized condition. An experiment is conducted to verify the feasibility of the TCG and the experimental results agree well with the theoretical prediction. The reconfigurability and stability of the obtained optical comb are discussed as well in the experiment. After that, the obtained optical comb is utilized as the optical source for a wavelength-division multiplexed radio-over-fiber (WDM-RoF) system and a hybrid WDM orthogonal frequency-division multiple access passive optical network (WDM-OFDMA-PON). Two corresponding experimental demonstrations are presented to verify the feasibility of employing the obtained flat optical comb as the WDM optical source, respectively. In the WDM-RoF system, 17 WDM channels each carrying 16×5 Gb/s non-return-to-zero (NRZ) data have been up-converted to 10 GHz simultaneously. In the hybrid WDM-OFDMA-PON, 17-channel OFDM-WDM double-sideband (DSB) signal achieving 10.85 Gb/s traffic per channel is successfully transmitted for both wired baseband OFDM access and wireless 10 GHz OFDM access.

  3. Automated generation of high-quality training data for appearance-based object models

    NASA Astrophysics Data System (ADS)

    Becker, Stefan; Voelker, Arno; Kieritz, Hilke; Hübner, Wolfgang; Arens, Michael

    2013-11-01

    Methods for automated person detection and person tracking are essential core components in modern security and surveillance systems. Most state-of-the-art person detectors follow a statistical approach, where prototypical appearances of persons are learned from training samples with known class labels. Selecting appropriate learning samples has a significant impact on the quality of the generated person detectors. For example, training a classifier on a rigid body model using training samples with strong pose variations is in general not effective, irrespective of the classifiers capabilities. Generation of high-quality training data is, apart from performance issues, a very time consuming process, comprising a significant amount of manual work. Furthermore, due to inevitable limitations of freely available training data, corresponding classifiers are not always transferable to a given sensor and are only applicable in a well-defined narrow variety of scenes and camera setups. Semi-supervised learning methods are a commonly used alternative to supervised training, in general requiring only few labeled samples. However, as a drawback semi-supervised methods always include a generative component, which is known to be difficult to learn. Therefore, automated processes for generating training data sets for supervised methods are needed. Such approaches could either help to better adjust classifiers to respective hardware, or serve as a complement to existing data sets. Towards this end, this paper provides some insights into the quality requirements of automatically generated training data for supervised learning methods. Assuming a static camera, labels are generated based on motion detection by background subtraction with respect to weak constraints on the enclosing bounding box of the motion blobs. Since this labeling method consists of standard components, we illustrate the effectiveness by adapting a person detector to cameras of a sensor network. While varying

  4. GPU-based Efficient Realistic Techniques for Bleeding and Smoke Generation in Surgical Simulators

    PubMed Central

    Halic, Tansel; Sankaranarayanan, Ganesh; De, Suvranu

    2010-01-01

    Background In actual surgery, smoke and bleeding due to cautery processes, provide important visual cues to the surgeon which have been proposed as factors in surgical skill assessment. While several virtual reality (VR)-based surgical simulators have incorporated effects of bleeding and smoke generation, they are not realistic due to the requirement of real time performance. To be interactive, visual update must be performed at least 30 Hz and haptic (touch) information must be refreshed at 1 kHz. Simulation of smoke and bleeding is, therefore, either ignored or simulated using highly simplified techniques since other computationally intensive processes compete for the available CPU resources. Methods In this work, we develop a novel low-cost method to generate realistic bleeding and smoke in VR-based surgical simulators which outsources the computations to the graphical processing unit (GPU), thus freeing up the CPU for other time-critical tasks. This method is independent of the complexity of the organ models in the virtual environment. User studies were performed using 20 subjects to determine the visual quality of the simulations compared to real surgical videos. Results The smoke and bleeding simulation were implemented as part of a Laparoscopic Adjustable Gastric Banding (LAGB) simulator. For the bleeding simulation, the original implementation using the shader did not incur in noticeable overhead. However, for smoke generation, an I/O (Input/Output) bottleneck was observed and two different methods were developed to overcome this limitation. Based on our benchmark results, a buffered approach performed better than a pipelined approach and could support up to 15 video streams in real time. Human subject studies showed that the visual realism of the simulations were as good as in real surgery (median rating of 4 on a 5-point Likert scale). Conclusions Based on the performance results and subject study, both bleeding and smoke simulations were concluded to be

  5. Experience in Developing a Single-Phase Two Winding 5 kW Self-excited Induction Generator for Off-Grid Renewable Energy Based Power Generation

    NASA Astrophysics Data System (ADS)

    Murthy, S. S.; Singh, Bhim; Sandeep, Vuddanti

    2016-06-01

    This paper deals with the design and development of a novel single-phase two winding self-excited squirrel cage induction generator (SEIG) for off-grid renewable energy based power generation. The principles underlying the design process and experience with SPEED design tool are described to design a 5 kW, 50 Hz, 230 V, 4 pole single phase AC generator. All possible configurations to reduce harmonic components of induced e.m.f. are attempted for desired performance and to get an optimum design keeping in view the manufacturing constraints. The development of a prototype based on this design has been completed with the help of an industry. Typical test results on the prototype are presented to demonstrate its performance. Computed results are obtained with a design based computational procedure for performance analysis and a critical comparison is made with test results.

  6. Fiber methane gas detector based on harmonic detection and application in ventilation air methane power generation

    NASA Astrophysics Data System (ADS)

    Li, Yanfang; Wei, Yubin; Shang, Ying; Zhao, Yanjie; Zhang, Tingting; Zhao, Weisong; Wang, Chang; Liu, Tongyu

    2010-10-01

    A fiber methane detector based on spectrum absorption is reported. The methane monitor use a distributed feedback diode lasers(DFB) which is near infrared spectroscopy as the optic source, we realized online harmonic detection of the methane. The advantages of this detector include high precision, elimination of interference from humidity and other gases as well as long recalibration cycle. The detection of CH4 is very important in the methane power generation. Especially the detection of the tail gas with high temperature is the dependence to judge the generator. In this paper, we give some data witch gained from the local of methane power generation. The data reach an agreement with the measurements of the sensor using in mine. And the detector has the function of self reference, so the detector is more depended. This proved that the fiber methane detector can meet the needs of the generator. It have some contribution to the production safety of the mine and the energy saving and emission reduction and the environmental protection.

  7. Attack on a Chaos-Based Random Number Generator Using Anticipating Synchronization

    NASA Astrophysics Data System (ADS)

    Yeniçeri, Ramazan; Kilinç, Selçuk; Yalçin, Müştak E.

    Chaotic systems have been used in random number generation, owing to the property of sensitive dependence on initial conditions and hence the possibility to produce unpredictable signals. Within the types of chaotic systems, those which are defined by only one delay-differential equation are attractive due to their simple model. On the other hand, it is possible to synchronize to the future states of a time-delay chaotic system by anticipating synchronization. Therefore, random number generator (RNG), which employs such a system, might not be immune to the attacks. In this paper, attack on a chaos-based random number generator using anticipating synchronization is investigated. The considered time-delay chaotic system produces binary signals, which can directly be used as a source of RNG. Anticipating synchronization is obtained by incorporating other systems appropriately coupled to the original one. Quantification of synchronization is given by the bit error between the streams produced by the original and coupled systems. It is shown that the bit streams generated by the original system can be anticipated by the coupled systems beforehand.

  8. MOSAIK: a hash-based algorithm for accurate next-generation sequencing short-read mapping.

    PubMed

    Lee, Wan-Ping; Stromberg, Michael P; Ward, Alistair; Stewart, Chip; Garrison, Erik P; Marth, Gabor T

    2014-01-01

    MOSAIK is a stable, sensitive and open-source program for mapping second and third-generation sequencing reads to a reference genome. Uniquely among current mapping tools, MOSAIK can align reads generated by all the major sequencing technologies, including Illumina, Applied Biosystems SOLiD, Roche 454, Ion Torrent and Pacific BioSciences SMRT. Indeed, MOSAIK was the only aligner to provide consistent mappings for all the generated data (sequencing technologies, low-coverage and exome) in the 1000 Genomes Project. To provide highly accurate alignments, MOSAIK employs a hash clustering strategy coupled with the Smith-Waterman algorithm. This method is well-suited to capture mismatches as well as short insertions and deletions. To support the growing interest in larger structural variant (SV) discovery, MOSAIK provides explicit support for handling known-sequence SVs, e.g. mobile element insertions (MEIs) as well as generating outputs tailored to aid in SV discovery. All variant discovery benefits from an accurate description of the read placement confidence. To this end, MOSAIK uses a neural-network based training scheme to provide well-calibrated mapping quality scores, demonstrated by a correlation coefficient between MOSAIK assigned and actual mapping qualities greater than 0.98. In order to ensure that studies of any genome are supported, a training pipeline is provided to ensure optimal mapping quality scores for the genome under investigation. MOSAIK is multi-threaded, open source, and incorporated into our command and pipeline launcher system GKNO (http://gkno.me). PMID:24599324

  9. Explicit symplectic algorithms based on generating functions for charged particle dynamics.

    PubMed

    Zhang, Ruili; Qin, Hong; Tang, Yifa; Liu, Jian; He, Yang; Xiao, Jianyuan

    2016-07-01

    Dynamics of a charged particle in the canonical coordinates is a Hamiltonian system, and the well-known symplectic algorithm has been regarded as the de facto method for numerical integration of Hamiltonian systems due to its long-term accuracy and fidelity. For long-term simulations with high efficiency, explicit symplectic algorithms are desirable. However, it is generally believed that explicit symplectic algorithms are only available for sum-separable Hamiltonians, and this restriction limits the application of explicit symplectic algorithms to charged particle dynamics. To overcome this difficulty, we combine the familiar sum-split method and a generating function method to construct second- and third-order explicit symplectic algorithms for dynamics of charged particle. The generating function method is designed to generate explicit symplectic algorithms for product-separable Hamiltonian with form of H(x,p)=p_{i}f(x) or H(x,p)=x_{i}g(p). Applied to the simulations of charged particle dynamics, the explicit symplectic algorithms based on generating functions demonstrate superiorities in conservation and efficiency. PMID:27575228

  10. Self-Assembled Nano-energetic Gas Generators based on Bi2O3

    NASA Astrophysics Data System (ADS)

    Hobosyan, Mkhitar; Trevino, Tyler; Martirosyan, Karen

    2012-10-01

    Nanoenergetic Gas-Generators are formulations that rapidly release a large amount of gaseous products and generate a fast moving thermal wave. They are mainly based on thermite systems, which are pyrotechnic mixtures of metal powders (fuel- Al, Mg, etc.) and metal oxides (oxidizer, Bi2O3, Fe2O3, WO3, MoO3 etc.) that can generate an exothermic oxidation-reduction reaction referred to as a thermite reaction. A thermite reaction releases a large amount of energy and can generate rapidly extremely high temperatures. The intimate contact between the fuel and oxidizer can be enhanced by use of nano instead of micro particles. The contact area between oxidizer and metal particles depends from method of mixture preparation. In this work we utilize the self-assembly processes, which use the electrostatic forces to produce ordered and self-organized binary systems. In this process the intimate contact significantly enhances and gives the ability to build an energetic material in molecular level, which is crucial for thepressure discharge efficiency of nano-thermites. The DTA-TGA, Zeta-size analysis and FTIR technique were performed to characterize the Bi2O3 particles. The self-assembly of Aluminum and Bi2O3 was conducted in sonic bath with appropriate solvents and linkers. The resultant thermite pressure discharge values were tested in modified Parr reactor. In general, the self-assembled thermites give much higher-pressure discharge values than the thermites prepared with conventional roll-mixing technique.

  11. Design of real-time locomotion generator with map-based neuronal models

    NASA Astrophysics Data System (ADS)

    Rulkov, Nikolai; Ayers, Joseph; Hunt, Mark

    2008-03-01

    We are developing an electronic nervous system for a biomimetic robot based on an established neurobiological model system, the Sea Lamprey. Undulatory locomotion of the lamprey is coordinated by a concatenated network of over 100 segmental central pattern generators (CPGs). To achieve real time operation in a DSP chip, we are using simple phenomenological models of neurons and synapses based on the dynamics of nonlinear maps. CPG networks based on known neuronal circuitry have replicated main properties of the dynamical behavior of the animal model. The results of numerical studies of the neuronal activity coordinating various swimming patterns in the reduced model of the CPG are considered. Both ascending and descending connections between segmental CPGs can mediate both forward and backward propagating flexion waves based on anterior or posterior bias by descending premotor commands. Bilaterally asymmetric biases of descending commands can mediate turning. The CPG outputs control 5 shape memory alloy actuators on each side to generate coordinated undulations. Two dorsal and ventral pitch actuators control the angle between the hull and undulator to control dive and climb. Descending commands are modulated by an analog compass, inclinometers, accelerometers and a short baseline sonar array to mediate homing by the vehicle on a sonar beacon.

  12. IR scene image generation from visual image based on thermal database

    NASA Astrophysics Data System (ADS)

    Liao, Binbin; Wang, Zhangye; Ke, Xiaodi; Xia, Yibin; Peng, Qunsheng

    2007-11-01

    In this paper, we propose a new method to generate complex IR scene image directly from the corresponding visual scene image based on material thermal database. For the input visual scene image, we realize an interactive tool based on the combined method of global magic wand and intelligent scissors to segment the object areas in the scene. And the thermal attributes are assigned to each object area from the thermal database of materials. By adopting the scene infrared signature model based on infrared Physics and Heat Transfer, the surface temperature distribution of the scene are calculated and the corresponding grayscale of each area in IR image is determined by our transformation rule. We also propose a pixel-based RGB spacial similarity model to determine the mixture grayscales of residual area in the scene image. To realistically simulate the IR scene, we develop an IR imager blur model considering the effect of different resolving power of visual and thermal imagers, IR atmospheric noise and the modulation transfer function of thermal imager. Finally, IR scene images at different intervals under different weather conditions are generated. Compared with real IR scene images, our simulated results are quite satisfactory and effective.

  13. Hardware random number generator base on monostable multivibrators dedicated for distributed measurement and control systems

    NASA Astrophysics Data System (ADS)

    Czernik, Pawel

    2013-10-01

    The hardware random number generator based on the 74121 monostable multivibrators for applications in cryptographically secure distributed measurement and control systems with asymmetric resources was presented. This device was implemented on the basis of the physical electronic vibration generator in which the circuit is composed of two "loop" 74121 monostable multivibrators, D flip-flop and external clock signal source. The clock signal, witch control D flip-flop was generated by a computer on one of the parallel port pins. There was presented programmed the author's acquisition process of random data from the measuring system to a computer. The presented system was designed, builded and thoroughly tested in the term of cryptographic security in our laboratory, what there is the most important part of this publication. Real cryptographic security was tested based on the author's software and the software environment called RDieHarder. The obtained results was here presented and analyzed in detail with particular reference to the specificity of distributed measurement and control systems with asymmetric resources.

  14. A sparse grid based method for generative dimensionality reduction of high-dimensional data

    NASA Astrophysics Data System (ADS)

    Bohn, Bastian; Garcke, Jochen; Griebel, Michael

    2016-03-01

    Generative dimensionality reduction methods play an important role in machine learning applications because they construct an explicit mapping from a low-dimensional space to the high-dimensional data space. We discuss a general framework to describe generative dimensionality reduction methods, where the main focus lies on a regularized principal manifold learning variant. Since most generative dimensionality reduction algorithms exploit the representer theorem for reproducing kernel Hilbert spaces, their computational costs grow at least quadratically in the number n of data. Instead, we introduce a grid-based discretization approach which automatically scales just linearly in n. To circumvent the curse of dimensionality of full tensor product grids, we use the concept of sparse grids. Furthermore, in real-world applications, some embedding directions are usually more important than others and it is reasonable to refine the underlying discretization space only in these directions. To this end, we employ a dimension-adaptive algorithm which is based on the ANOVA (analysis of variance) decomposition of a function. In particular, the reconstruction error is used to measure the quality of an embedding. As an application, the study of large simulation data from an engineering application in the automotive industry (car crash simulation) is performed.

  15. Generation of knockout alleles by RFLP based BAC targeting of polymorphic embryonic stem cells.

    PubMed

    Barakat, Tahsin Stefan; Gribnau, Joost

    2015-01-01

    The isolation of germ line competent mouse Embryonic Stem (ES) cells and the ability to modify the genome by homologous recombination has revolutionized life science research. Since its initial discovery, several approaches have been introduced to increase the efficiency of homologous recombination, including the use of isogenic DNA for the generation of targeting constructs, and the use of Bacterial Artificial Chromosomes (BACs). BACs have the advantage of combining long stretches of homologous DNA, thereby increasing targeting efficiencies, with the possibilities delivered by BAC recombineering approaches, which provide the researcher with almost unlimited possibilities to efficiently edit the genome in a controlled fashion. Despite these advantages of BAC targeting approaches, a widespread use has been hampered, mainly because of the difficulties in identifying BAC-targeted knockout alleles by conventional methods like Southern Blotting. Recently, we introduced a novel BAC targeting strategy, in which Restriction Fragment Length Polymorphisms (RFLPs) are targeted in polymorphic mouse ES cells, enabling an efficient and easy PCR-based readout to identify properly targeted alleles. Here we provide a detailed protocol for the generation of targeting constructs, targeting of ES cells, and convenient PCR-based analysis of targeted clones, which enable the user to generate knockout ES cells of almost every gene in the mouse genome within a 2-month period. PMID:25239745

  16. An irregular wave generating approach based on naoe-FOAM-SJTU solver

    NASA Astrophysics Data System (ADS)

    Shen, Zhi-rong; Wan, De-cheng

    2016-04-01

    In this paper, a wave generating approach for long-crest irregular waves in a numerical tank by our in-house solver naoe-FOAM-SJTU is presented. The naoe-FOAM-SJTU solver is developed using an open source tool kit, OpenFOAM. Reynolds-averaged Navier-Stokes (RANS) equations are chosen as governing equations and the volume of fluid (VOF) is employed to capture the two phases interface. Incoming wave group is generated by imposing the boundary conditions of the tank inlet. A spectrum based correction procedure is developed to make the measured spectrum approaching to the target spectrum. This procedure can automatically adjust the wave generation signal based on the measured wave elevation by wave height probe in numerical wave tank. After 3 to 4 iterations, the measured spectrum agrees well with the target one. In order to validate this method, several wave spectra are chosen and validated in the numerical wave tank, with comparison between the final measured and target spectra. In order to investigate a practical situation, a modified Wigley hull is placed in the wave tank with incoming irregular waves. The wave-induced heave and pitch motions are treated by Fourier analysis to obtain motion responses, showing good agreements with the measurements.

  17. A 6 GW nanosecond solid-state generator based on semiconductor opening switch

    NASA Astrophysics Data System (ADS)

    Gusev, A. I.; Pedos, M. S.; Rukin, S. N.; Timoshenkov, S. P.; Tsyranov, S. N.

    2015-11-01

    In this paper, a nanosecond all solid-state generator providing peak power of up to 6 GW, output voltage of 500-900 kV, pulse length (full width at half maximum) of ˜7 ns across external loads of 40-100 Ω, and pulse repetition frequency up to 1 kHz in burst operation mode is described. The output pulse is generated by a semiconductor opening switch (SOS). A new SOS pumping circuit based on a double forming line (DFL) is proposed and its implementation described. As compared with a lumped capacitors-based pumping circuit, the DFL allows minimization of the inductance and stray capacitance of the reverse pumping circuit, and thus, an increase in the SOS cutoff current amplitude and generator output peak power as a whole. The pumping circuit provides a reverse current increasing through the SOS up to 14 kA within ˜12 ns. The SOS cuts off the current in ˜2 ns; the current cutoff rate reaches 7 kA/ns. The SOS braking power (the product of peak voltage and cutoff current) for an external load above 100 Ω is 13 GW.

  18. Robust thin-film generator based on segmented contact-electrification for harvesting wind energy.

    PubMed

    Meng, Xian Song; Zhu, Guang; Wang, Zhong Lin

    2014-06-11

    Collecting and converting energy from ambient air flow promise to be a viable approach in developing self-powered autonomous electronics. Here, we report an effective and robust triboelectric generator that consists of an undulating thin-film membrane and an array of segmented fine-sized electrode pairs on a single substrate. Sequential processes of contact electrification and electrostatic induction generate alternating flows of free electrons when the membrane interacts with ambient air flow. Based on an optimum rational design, the segmented electrodes play an essential role in boosting the output current, leading to an enhancement of over 500% compared to the structure without the segmentation. The thin-film based generator can simultaneously and continuously light up tens of commercial light-emitting diodes. Moreover, it possesses exceptional durability, providing constant electric output after millions of operation cycles. This work offers a truly practical solution that opens the avenue to take advantage of wind energy by using the triboelectric effect. PMID:24824071

  19. SOM-based Pattern Generator: Pattern Generation Based on the Backward Projection in a Self-Organizing Map and Its Applications

    NASA Astrophysics Data System (ADS)

    Wakuya, Hiroshi; Ishiguma, Takahiro

    A major feature of the self-organizing map (SOM) is a topology-preserving projection from the input layer to the competitive layer, and it has been used mainly as an analytical tool for discovering underlying rules in the given data set. Even though recent splendid progress in this area, there are few novel ideas to break such a conventional style. On the contrary, based on its distinctive nature, a new method for generating patterns through backward projection from the competitive layer to the input layer is proposed recently. Moreover, a promising technology for producing animation as a series of backward-projected patterns along with any pathways on the competitive layer is presented. Then, in order to carry out further considerations, some computer simulations with a variety of posed stick figures are tried in this paper. After training, four kinds of pathways, which correspond to different movements such as dancing, exercising and walking, are prepared. Though some of them does not contain any training samples, all of them worked well as we have intended in advance. As a result, it is found that the proposed method shows good performance and it is also confirmed its effectiveness.

  20. 78 FR 56690 - PE Hydro Generation, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission PE Hydro Generation, LLC; Supplemental Notice That Initial Market-Based Rate...-referenced proceeding, of PE Hydro Generation, LLC's application for market-based rate authority, with...

  1. 77 FR 279 - Brea Generation LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-04

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Brea Generation LLC; Supplemental Notice That Initial Market- Based Rate...-referenced proceeding of Brea Generation LLC's application for market-based rate authority, with...

  2. 76 FR 32188 - Tanner Street Generation, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-03

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Tanner Street Generation, LLC; Supplemental Notice That Initial Market-Based... above-referenced proceeding of Tanner Street Generation, LLC's application for market-based...

  3. 78 FR 56691 - Lake Lynn Generation, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Lake Lynn Generation, LLC; Supplemental Notice That Initial Market-Based... above-referenced proceeding, of Lake Lynn Generation, LLC's application for market-based rate...

  4. 77 FR 64981 - Homer City Generation, L.P.; Supplemental Notice That Initial Market-Based Rate Filing Includes...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Homer City Generation, L.P.; Supplemental Notice That Initial Market-Based... above-referenced proceeding of Homer City Generation, L.P.'s application for market-based rate...

  5. 78 FR 44109 - AEP Generation Resources Inc.; Supplemental Notice That Initial Market-Based Rate Filing Includes...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission AEP Generation Resources Inc.; Supplemental Notice That Initial Market-Based... above-referenced proceeding, of AEP Generation Resources Inc.'s application for market-based...

  6. 78 FR 56690 - All Dams Generation, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission All Dams Generation, LLC; Supplemental Notice That Initial Market-Based Rate...-referenced proceeding, of All Dams Generation, LLC's application for market-based rate authority, with...

  7. Generating Pedestrian Trajectories Consistent with the Fundamental Diagram Based on Physiological and Psychological Factors

    PubMed Central

    Narang, Sahil; Best, Andrew; Curtis, Sean; Manocha, Dinesh

    2015-01-01

    Pedestrian crowds often have been modeled as many-particle system including microscopic multi-agent simulators. One of the key challenges is to unearth governing principles that can model pedestrian movement, and use them to reproduce paths and behaviors that are frequently observed in human crowds. To that effect, we present a novel crowd simulation algorithm that generates pedestrian trajectories that exhibit the speed-density relationships expressed by the Fundamental Diagram. Our approach is based on biomechanical principles and psychological factors. The overall formulation results in better utilization of free space by the pedestrians and can be easily combined with well-known multi-agent simulation techniques with little computational overhead. We are able to generate human-like dense crowd behaviors in large indoor and outdoor environments and validate the results with captured real-world crowd trajectories. PMID:25875932

  8. A PC-based generator of surface ECG potentials for computer electrocardiograph testing.

    PubMed

    Franchi, D; Palagi, G; Bedini, R

    1994-02-01

    The system is composed of an electronic circuit, connected to a PC, whose outputs, starting from ECGs digitally collected by commercial interpretative electrocardiographs, simulate virtual patients' limb and chest electrode potentials. Appropriate software manages the D/A conversion and lines up the original short-term signal in a ring buffer to generate continuous ECG traces. The device also permits the addition of artifacts and/or baseline wanders/shifts on each lead separately. The system has been accurately tested and statistical indexes have been computed to quantify the reproduction accuracy analyzing, in the generated signal, both the errors induced on the fiducial point measurements and the capability to retain the diagnostic significance. The device integrated with an annotated ECG data base constitutes a reliable and powerful system to be used in the quality assurance testing of computer electrocardiographs. PMID:8004944

  9. An improved model for fragment-based lead generation at AstraZeneca.

    PubMed

    Fuller, Nathan; Spadola, Loredana; Cowen, Scott; Patel, Joe; Schönherr, Heike; Cao, Qing; McKenzie, Andrew; Edfeldt, Fredrik; Rabow, Al; Goodnow, Robert

    2016-08-01

    Modest success rates in fragment-based lead generation (FBLG) projects at AstraZeneca (AZ) prompted operational changes to improve performance. In this review, we summarize these changes, emphasizing the construction and composition of the AZ fragment library, screening practices and working model. We describe the profiles of the screening method for specific fragment subsets and statistically assess our ability to follow up on fragment hits through near-neighbor selection. Performance analysis of our second-generation fragment library (FL2) in screening campaigns illustrates the complementary nature of flat and 3D fragments in exploring protein-binding pockets and highlights our ability to deliver fragment hits using multiple screening techniques for various target classes. The new model has had profound impact on the successful delivery of lead series to drug discovery projects. PMID:27179986

  10. Reconfigurable optofluidic switch for generation of optical pulse width modulation based on tunable reflective interface.

    PubMed

    Mansuori, M; Zareei, G H; Hashemi, H

    2015-10-01

    We present a numerical method for generation of optical pulse width modulation (PWM) based on tunable reflective interface by using a microfluidic droplet. We demonstrate a single layer, planar, optofluidic PWM switch that is driven by excited alternating microbubbles. The main parameters of generation of this PWM such as frequency and speed of switching can be controlled by the mass flow rates of input fluids, and the shape of plug or droplet. Advantages of this design are the reconfigurability in design and the easy control of the switching parameters. The validation of the proposed design is carried out by employing the finite element method (FEM) for the mechanical simulation and the finite-difference time-domain (FDTD) for the optical simulation. PMID:26479666

  11. Investigation of spontaneous Brillouin scattering generation based on non-adiabatic microfibres

    NASA Astrophysics Data System (ADS)

    Zarei, A.; Jasim, A. A.; Harun, S. W.; Ahmad, H.

    2014-12-01

    Brillouin Stokes and anti-Stokes generation is successfully demonstrated in backward direction using a non-adiabatic microfibre as the gain medium. The Stokes light wavelength is up-shifted by 0.088 nm (10 GHz) from the BP wavelength as monitored by using an optical spectrum analyzer. The Brillouin scattering can also be enhanced by employing a microfibre based inline Mach-Zehnder interferometer (IMZI) as the gain medium due to its stronger multimode interference effect. It is shown that the microfibre geometry plays an important role in the spontaneous Brillouin scattering generation and gain bandwidth broadening due to its effect on irritation of the acoustic modes inside the microfibre.

  12. MOSFET-based high voltage double square-wave pulse generator with an inductive adder configuration

    NASA Astrophysics Data System (ADS)

    Zhao, Xin; Zhang, Qiaogen; Long, Jinghua; Lei, Yunfei; Liu, Jinyuan

    2015-09-01

    This paper presents a fast MOSFET-based solid-state pulse generator for high voltage double square-wave pulses. The generator consists mainly of an inductive adder system stacked of 20 solid-state modules. Each of the modules has 18 power MOSFETs in parallel, which are triggered by individual drive circuits; these drive circuits themselves are synchronously triggered by a signal from avalanche transistors. Our experiments demonstrate that the output pulses with amplitude of 8.1 kV and peak current of about 405 A are available at a load impedance of 20 Ω. The pulse has a double square-wave form with a rise and fall time of 40 ns and 26 ns, respectively and bottom flatness better than 12%. The interval time of the double square-wave pulses can be adjustable by varying the interval time of the trigger pulses.

  13. Slow-fast effect and generation mechanism of brusselator based on coordinate transformation

    NASA Astrophysics Data System (ADS)

    Li, Xianghong; Hou, Jingyu; Shen, Yongjun

    2016-08-01

    The Brusselator with different time scales, which behaves in the classical slow-fast effect, is investigated, and is characterized by the coupling of the quiescent and spiking states. In order to reveal the generation mechanism by using the slow-fast analysis method, the coordinate transformation is introduced into the classical Brusselator, so that the transformed system can be divided into the fast and slow subsystems. Furthermore, the stability condition and bifurcation phenomenon of the fast subsystem are analyzed, and the attraction domains of different equilibria are presented by theoretical analysis and numerical simulation respectively. Based on the transformed system, it could be found that the generation mechanism between the quiescent and spiking states is Fold bifurcation and change of the attraction domain of the fast subsystem. The results may also be helpful to the similar system with multiple time scales.

  14. Third generation biosensing matrix based on Fe-implanted ZnO thin film

    NASA Astrophysics Data System (ADS)

    Saha, Shibu; Gupta, Vinay; Sreenivas, K.; Tan, H. H.; Jagadish, C.

    2010-09-01

    Third generation biosensor based on Fe-implanted ZnO (Fe-ZnO) thin film has been demonstrated. Implantation of Fe in rf-sputtered ZnO thin film introduces redox center along with shallow donor level and thereby enhance its electron transfer property. Glucose oxidase (GOx), chosen as model enzyme, has been immobilized on the surface of the matrix. Cyclic voltammetry and photometric assay show that the prepared bioelectrode, GOx/Fe-ZnO/ITO/Glass is sensitive to the glucose concentration with enhanced response of 0.326 μA mM-1 cm-2 and low Km of 2.76 mM. The results show promising application of Fe-implanted ZnO thin film as an attractive matrix for third generation biosensing.

  15. Compact Intense Neutron Generators Based on Inertial Electrostatic Confinement of D-D Fusion Plasmas

    NASA Astrophysics Data System (ADS)

    Masuda, K.; Inoue, K.; Kajiwara, T.; Nakamatsu, R.

    2015-10-01

    A neutron generator based on inertial electrostatic confinement (IEC) of fusion plasmas is being developed for a non-destructive inspection system of special nuclear materials hidden in sea containers. The new IEC device is equipped with a multistage feedthrough which was designed aiming at both capability of a high bias voltage and enhancement of ion recirculation by modification of electric fields in the IEC device. Experimental comparison was made with a conventional single-stage IEC device developed in an earlier work. As the results, both the increase in the applied voltage and the modified field symmetry by the new multistage scheme showed significant enhancement in the neutron output. As a consequence, neutron output per input discharge current was enhanced drastically by a factor of ~30 in total. Also, the first pulsing experiments of the newly developed IEC neutron generator showed pulsed neutron output with a rapid pulse fall-off of ~ 1 μsec successfully.

  16. A semiconductor opening switch based generator with pulse repetitive frequency of 4 MHz.

    PubMed

    Wang, Gang; Su, Jiancang; Ding, Zhenjie; Yuan, Xuelin; Pan, Yafeng

    2013-12-01

    A MHz repetitive and nanosecond pulsed power generator based on the semiconductor opening switch (SOS) is developed, in which the pulse compression unit utilizes several Radio Frequency (RF) MOSFETs and a saturable Linear Transformer Driver (LTD). The RF MOSFETs are employed to obtain the forward pumping current pulses with the duration of tens of nanoseconds; the saturable LTD is used to raise the pulse voltage, to compress the pulse width and to pump SOS reversely. The SOS assembly cuts off the reverse current in a few nanoseconds, leading to a narrow output pulse on an external load. The experimental results show that the amplitude of the output pulse on a 106 Ω resistive load is about 3.8 kV and the width is 2 ns. Due to the repetitive ability of the RF MOSFETs, the generator can operate at a repetitive frequency of higher than 4 MHz in burst mode. PMID:24387463

  17. Generation of Radiation Pressure in Thermally Induced Ultrasonic Emitter Based on Nanocrystalline Silicon

    NASA Astrophysics Data System (ADS)

    Hirota, Jun; Shinoda, Hiroyuki; Koshida, Nobuyoshi

    2004-04-01

    To confirm the applicability of thermally induced ultrasonic emission from nanocrystalline silicon (nc-Si) devices as radiation pressure generators, the dynamic response has been investigated under a pulse operation mode. The nc-Si emitter is fabricated on a p-type Si wafer by conventional electrochemical anodization with subsequent formation of the surface electrode. Due to the flat nature of the frequency response of this emitter, the device emits an acoustic wave with little distortion under the pulse-drive condition. It is shown that a significant radiation pressure of 34.5 Pa is generated by a concentrated burst-like electrical input, and that a beam located at a distance can be levitated as a result of the mechanical loading effect. This silicon-based emitter is attractive for applications to integrated nano- or micro-electromechanical systems.

  18. Status and plans for future generations of ground-based interferometric gravitational wave antennas

    NASA Astrophysics Data System (ADS)

    Kawamura, Seiji

    2003-05-01

    Several medium- to large-scale ground-based interferometric gravitational-wave antennas have been constructed around the world. Although these antennas of the first generation could detect gravitational waves within a few years, it is necessary to improve the sensitivity of the detectors significantly with advanced technologies to ensure more frequent detection of gravitational waves. Stronger seismic isolation and reduction of thermal noise, especially using cryogenic mirrors, are among the most important technologies that can lead us to the realization of advanced detectors. Some of the advanced technologies are already implemented in some of the existing detectors and others are currently being investigated for the future-generation detectors such as advanced LIGO, LCGT, upgrade of GEO600, AIGO, and EURO. We expect that such advanced detectors will eventually open a new window to the universe and establish a new field, 'gravitational wave astronomy'.

  19. A geometry-based adaptive unstructured grid generation algorithm for complex geological media

    NASA Astrophysics Data System (ADS)

    Bahrainian, Seyed Saied; Dezfuli, Alireza Daneh

    2014-07-01

    In this paper a novel unstructured grid generation algorithm is presented that considers the effect of geological features and well locations in grid resolution. The proposed grid generation algorithm presents a strategy for definition and construction of an initial grid based on the geological model, geometry adaptation of geological features, and grid resolution control. The algorithm is applied to seismotectonic map of the Masjed-i-Soleiman reservoir. Comparison of grid results with the “Triangle” program shows a more suitable permeability contrast. Immiscible two-phase flow solutions are presented for a fractured porous media test case using different grid resolutions. Adapted grid on the fracture geometry gave identical results with that of a fine grid. The adapted grid employed 88.2% less CPU time when compared to the solutions obtained by the fine grid.

  20. Keyframe generation from cartoon animation using rule-based optical flow

    NASA Astrophysics Data System (ADS)

    Tanapichet, Pakpoom; Cooharojananone, Nagul; Lipikorn, Rajalida

    2012-02-01

    This paper proposes a novel method to generate keyframes from cartoon animation with the aim to improve the details and accuracy of contents represented by keyframes. Consider that general techniques on video summarization usually drop some important contents due to its restriction on aspect ratio; this paper thus proposes a new method using panorama technology to add more details to be included in each keyframe. The concept is to mark the time code based on shot boundary and optical flow direction. The period of time between every two consecutive marked time codes is used to form a shot sequence which is actually a sequence of frames. The global and local optical flows are also used to determine how to select the frames and when to stitch the frames together according to the rules. The results of this proposed method are keyframes generated from various types of cartoon animation which are outstanding compared to their comic adaptations.

  1. Automatic feature template generation for maximum entropy based intonational phrase break prediction

    NASA Astrophysics Data System (ADS)

    Zhou, You

    2013-03-01

    The prediction of intonational phrase (IP) breaks is important for both the naturalness and intelligibility of Text-to- Speech (TTS) systems. In this paper, we propose a maximum entropy (ME) model to predict IP breaks from unrestricted text, and evaluate various keyword selection approaches in different domains. Furthermore, we design a hierarchical clustering algorithm for automatic generation of feature templates, which minimizes the need for human supervision during ME model training. Results of comparative experiments show that, for the task of IP break prediction, ME model obviously outperforms classification and regression tree (CART), log-likelihood ratio is the best scoring measure of keyword selection, compared with manual templates, templates automatically generated by our approach greatly improves the F-score of ME based IP break prediction, and significantly reduces the size of ME model.

  2. Tungsten disulphide based all fiber Q-switching cylindrical-vector beam generation

    SciTech Connect

    Lin, J.; Yan, K.; Zhou, Y.; Xu, L. X. Gu, C.; Zhan, Q. W.

    2015-11-09

    We proposed and demonstrated an all fiber passively Q-switching laser to generate cylindrical-vector beam, a two dimensional material, tungsten disulphide (WS{sub 2}), was adopted as a saturable absorber inside the laser cavity, while a few-mode fiber Bragg grating was used as a transverse mode-selective output coupler. The repetition rate of the Q-switching output pulses can be varied from 80 kHz to 120 kHz with a shortest duration of 958 ns. Attributed to the high damage threshold and polarization insensitivity of the WS{sub 2} based saturable absorber, the radially polarized beam and azimuthally polarized beam can be easily generated in the Q-switching fiber laser.

  3. A workflow for patient-individualized virtual angiogram generation based on CFD simulation.

    PubMed

    Endres, Jürgen; Kowarschik, Markus; Redel, Thomas; Sharma, Puneet; Mihalef, Viorel; Hornegger, Joachim; Dörfler, Arnd

    2012-01-01

    Increasing interest is drawn on hemodynamic parameters for classifying the risk of rupture as well as treatment planning of cerebral aneurysms. A proposed method to obtain quantities such as wall shear stress, pressure, and blood flow velocity is to numerically simulate the blood flow using computational fluid dynamics (CFD) methods. For the validation of those calculated quantities, virtually generated angiograms, based on the CFD results, are increasingly used for a subsequent comparison with real, acquired angiograms. For the generation of virtual angiograms, several patient-specific parameters have to be incorporated to obtain virtual angiograms which match the acquired angiograms as best as possible. For this purpose, a workflow is presented and demonstrated involving multiple phantom and patient cases. PMID:23193428

  4. A Workflow for Patient-Individualized Virtual Angiogram Generation Based on CFD Simulation

    PubMed Central

    Endres, Jürgen; Kowarschik, Markus; Redel, Thomas; Sharma, Puneet; Mihalef, Viorel; Hornegger, Joachim; Dörfler, Arnd

    2012-01-01

    Increasing interest is drawn on hemodynamic parameters for classifying the risk of rupture as well as treatment planning of cerebral aneurysms. A proposed method to obtain quantities such as wall shear stress, pressure, and blood flow velocity is to numerically simulate the blood flow using computational fluid dynamics (CFD) methods. For the validation of those calculated quantities, virtually generated angiograms, based on the CFD results, are increasingly used for a subsequent comparison with real, acquired angiograms. For the generation of virtual angiograms, several patient-specific parameters have to be incorporated to obtain virtual angiograms which match the acquired angiograms as best as possible. For this purpose, a workflow is presented and demonstrated involving multiple phantom and patient cases. PMID:23193428

  5. Native Cellulose Microfiber-Based Hybrid Piezoelectric Generator for Mechanical Energy Harvesting Utility.

    PubMed

    Alam, Md Mehebub; Mandal, Dipankar

    2016-01-27

    A flexible hybrid piezoelectric generator (HPG) based on native cellulose microfiber (NCMF) and polydimethylsiloxane (PDMS) with multi wall carbon nanotubes (MWCNTs) as conducting filler is presented where the further chemical treatment of the cellulose and traditional electrical poling steps for piezoelectric voltage generation is avoided. It delivers a high electrical throughput that is an open circuit voltage of ∼30 V and power density ∼9.0 μW/cm(3) under repeated hand punching. We demonstrate to power up various portable electronic units by HPG. Because cellulose is a biocompatible material, suggesting that HPG may have greater potential in biomedical applications such as implantable power source in human body. PMID:26760435

  6. Ambient formaldehyde detection with a laser spectrometer based on difference-frequency generation in PPLN

    NASA Technical Reports Server (NTRS)

    Rehle, D.; Leleux, D.; Erdelyi, M.; Tittel, F.; Fraser, M.; Friedfeld, S.

    2001-01-01

    A laser spectrometer based on difference-frequency generation in periodically poled LiNbO3 (PPLN) has been used to quantify atmospheric formaldehyde with a detection limit of 0.32 parts per billion in a given volume (ppbV) using specifically developed data-processing techniques. With state-of-the-art fiber-coupled diode-laser pump sources at 1083 nm and 1561 nm, difference-frequency radiation has been generated in the 3.53-micrometers (2832-cm-1) spectral region. Formaldehyde in ambient air in the 1- to 10-ppb V range has been detected continuously for nine and five days at two separate field sites in the Greater Houston area operated by the Texas Natural Resource Conservation Commission (TNRCC) and the Houston Regional Monitoring Corporation (HRM). The acquired spectroscopic data are compared with results obtained by a well-established wet-chemical o-(2,3,4,5,6-pentafluorobenzyl) hydroxylamine (PFBHA) technique.

  7. Photo-driven autonomous hydrogen generation system based on hierarchically shelled ZnO nanostructures

    SciTech Connect

    Kim, Heejin; Yong, Kijung

    2013-11-25

    A quantum dot semiconductor sensitized hierarchically shelled one-dimensional ZnO nanostructure has been applied as a quasi-artificial leaf for hydrogen generation. The optimized ZnO nanostructure consists of one dimensional nanowire as a core and two-dimensional nanosheet on the nanowire surface. Furthermore, the quantum dot semiconductors deposited on the ZnO nanostructures provide visible light harvesting properties. To realize the artificial leaf, we applied the ZnO based nanostructure as a photoelectrode with non-wired Z-scheme system. The demonstrated un-assisted photoelectrochemical system showed the hydrogen generation properties under 1 sun condition irradiation. In addition, the quantum dot modified photoelectrode showed 2 mA/cm{sup 2} current density at the un-assisted condition.

  8. Thermal neutron analysis (TNA) explosive detection based on electronic neutron generators

    NASA Astrophysics Data System (ADS)

    Lee, W. C.; Mahood, D. B.; Ryge, P.; Shea, P.; Gozani, T.

    1995-05-01

    Thermal neutron analysis explosive detection systems have been developed and demonstrated for inspection of checked airline baggage and for detection of buried land mines. Thermal neutrons from a moderated neutron source impinge on the inspected object, and the resulting capture gamma ray signatures provide detection information. Isotopic neutron sources, e.g. 252Cf, are compact, economical and reliable, but they are subject to the licensing requirements, safety concerns and public perception problems associated with radioactive material. These are mitigated by use of an electronic neutron generator — an ion accelerator with a target producing neutrons by a nuclear reaction such as D(d, n) 3He or 9Be(d, n) 10B. With suitable moderator designs based on neutron transport codes, operational explosive detection systems can be built and would provide effective alternatives to radioactive neutron sources. Calculations as well as laboratory and field experience with three generator types will be presented.

  9. Third generation biosensing matrix based on Fe-implanted ZnO thin film

    SciTech Connect

    Saha, Shibu; Gupta, Vinay; Sreenivas, K.; Tan, H. H.; Jagadish, C.

    2010-09-27

    Third generation biosensor based on Fe-implanted ZnO (Fe-ZnO) thin film has been demonstrated. Implantation of Fe in rf-sputtered ZnO thin film introduces redox center along with shallow donor level and thereby enhance its electron transfer property. Glucose oxidase (GOx), chosen as model enzyme, has been immobilized on the surface of the matrix. Cyclic voltammetry and photometric assay show that the prepared bioelectrode, GOx/Fe-ZnO/ITO/Glass is sensitive to the glucose concentration with enhanced response of 0.326 {mu}A mM{sup -1} cm{sup -2} and low Km of 2.76 mM. The results show promising application of Fe-implanted ZnO thin film as an attractive matrix for third generation biosensing.

  10. A robust random number generator based on differential comparison of chaotic laser signals.

    PubMed

    Zhang, Jianzhong; Wang, Yuncai; Liu, Ming; Xue, Lugang; Li, Pu; Wang, Anbang; Zhang, Mingjiang

    2012-03-26

    We experimentally realize a robust real-time random number generator by differentially comparing the signal from a chaotic semiconductor laser and its delayed signal through a 1-bit analog-to-digital converter. The probability density distribution of the output chaotic signal based on the differential comparison method possesses an extremely small coefficient of Pearson's median skewness (1.5 × 10⁻⁶), which can yield a balanced random sequence much easily than the previously reported method that compares the signal from the chaotic laser with a certain threshold value. Moveover, we experimently demonstrate that our method can stably generate good random numbers at rates of 1.44 Gbit/s with excellent immunity from external perturbations while the previously reported method fails. PMID:22453429

  11. Generating intense fully coherent soft x-ray radiation based on a laser-plasma accelerator.

    PubMed

    Feng, Chao; Xiang, Dao; Deng, Haixiao; Huang, Dazhang; Wang, Dong; Zhao, Zhentang

    2015-06-01

    Laser-plasma based accelerator has the potential to dramatically reduce the size and cost of future x-ray light sources to the university-laboratory scale. However, the large energy spread of the laser-plasma accelerated electron beam may hinder the way for short wavelength free-electron laser generation. In this paper, we propose a novel method for directly imprinting strong coherent micro-bunching on the electron beam with large intrinsic energy spread by using a wavefront-tilted conventional optical laser beam and a weak dipole magnet. Theoretical analysis and numerical simulations demonstrate that this technique can be used for the generation of fully coherent femtosecond soft x-ray radiation at gigawatts level with a very short undulator. PMID:26072855

  12. Building the Knowledge Base to Support the Automatic Animation Generation of Chinese Traditional Architecture

    NASA Astrophysics Data System (ADS)

    Wei, Gongjin; Bai, Weijing; Yin, Meifang; Zhang, Songmao

    We present a practice of applying the Semantic Web technologies in the domain of Chinese traditional architecture. A knowledge base consisting of one ontology and four rule bases is built to support the automatic generation of animations that demonstrate the construction of various Chinese timber structures based on the user's input. Different Semantic Web formalisms are used, e.g., OWL DL, SWRL and Jess, to capture the domain knowledge, including the wooden components needed for a given building, construction sequence, and the 3D size and position of every piece of wood. Our experience in exploiting the current Semantic Web technologies in real-world application systems indicates their prominent advantages (such as the reasoning facilities and modeling tools) as well as the limitations (such as low efficiency).

  13. Microfiber-based gold nanorods as saturable absorber for femtosecond pulse generation in a fiber laser

    SciTech Connect

    Wang, Xu-De; Luo, Zhi-Chao; Liu, Hao; Liu, Meng; Luo, Ai-Ping Xu, Wen-Cheng

    2014-10-20

    We reported on the femtosecond pulse generation from an erbium-doped fiber (EDF) laser by using microfiber-based gold nanorods (GNRs) as saturable absorber (SA). By virtue of the geometric characteristic of microfiber-based GNRs, the optical damage threshold of GNRs-SA could be greatly enhanced. The microfiber-based GNRs-SA shows a modulation depth of 4.9% and a nonsaturable loss of 21.1%. With the proposed GNRs-SA, the fiber laser emitted a mode-locked pulse train with duration of ∼887 fs. The obtained results demonstrated that the GNRs deposited microfiber could indeed serve as a high-performance SA towards the practical applications in the field of ultrafast photonics.

  14. Extragalactic Science with the Next Generation of Ground Based TeV {gamma}-Ray Telescopes

    SciTech Connect

    Krawczynski, Henric

    2008-12-24

    The ground based Cherenkov telescope experiments H.E.S.S., MAGIC, and VERITAS, and the space borne Fermi Gamma-Ray Space Telescope are currently exploring the galactic and extragalactic Universe in {gamma}-rays. At the time of writing this article, a large number of Active Galactic Nuclei have been studied in great detail and the {gamma}-ray observations have had a major impact on our understanding of the structure of jets from these objects. In this contribution, the status of ground based {gamma}-ray observations of AGN and other extragalactic source classes is reviewed as of October, 2008. After discussing source classes that could be detected with next generation ground based experiments like AGIS, CTA, and HAWC, the potential impact of the observations on the fields of high energy astrophysics, structure formation, observational cosmology, and fundamental physics is reviewed. We close with a discussion of the technical requirements that arise from the science drivers.

  15. Truck co-generation system based on combustion heated thermoelectric conversion

    SciTech Connect

    Meleta, Ye.A.; Yarygin, V.I.; Klepikov, V.V.; Wolff, L.R.

    1997-12-31

    Among the micro-co-generation systems using direct conversion of combustion heat into electricity (thermionic, thermoelectric converters) and fuel cells with an electric power of up to several kW, only the thermoelectric co-generation systems have a demonstrated life-time of up to 10 years. This is one of the most important factors making these systems a more likely commercialization candidate. The report deals with a conceptual design of a combustion heated thermoelectric cogeneration system to be applied in vehicles (truck, trailer, yacht, etc.). The authors named these systems the Thermoelectric Transport Co-generation Systems (TTCS). The report is concerned with one example of these systems--the Thermoelectric Truck Co-generation System (TT-kCS) designed to support the lives of both the driver and the car, when operating in the northern regions. In particular, the TT-kCS should provide the start-up of the cold engine of a truck at an ambient temperature of down to 50 C below zero and create comfortable conditions for a driver during the long-term halts and in emergency situations. The estimates made for a standard truck with an engine of 210 HP employed in Russia showed that the TT-kCS should generate {approximately}600 W of electrical power and {approximately}18 kW of heat. The report deals with two options for the thermoelectric converter design: one of them using the planar geometry of thermoelectric batteries, and the other one using a radial-cylindrical thermoelectric battery configuration. The economic feasibility of the TT-kCS application is based on a considerable reduction in fuel consumption of the TT-kCS equipped truck as compared to that of a conventional truck when the engine is idling. Another advantage is the prolongation of the engine`s service life.

  16. Ocean-generated magnetic field study based on satellite geomagnetic measurements: 2. Signal inference

    NASA Astrophysics Data System (ADS)

    Golubev, Yury

    2012-09-01

    The work presented here is the second part of an ocean-generated magnetic field study and provides a procedure for inferring the ocean-generated magnetic field from satellite geomagnetic measurements. The procedure was first tested on synthetic data. The simulation employed a hypothetical satellite measuring the magnetic field at an altitude of 400 km. The “measurements” (generated by the CM4 and CHAOS models) included the core field, the lithospheric field, the ionospheric and magnetospheric fields, the secular variation, and the ocean-generated magnetic field. The search algorithm, as proposed in part 1, converts irregular measurements into fields on a regular grid. The filtration procedure is based on the Savitzky-Golay algorithm. The procedure includes four steps providing seven unknown filter parameters. Parameter values were obtained by solving the problem of minimizing the spatially averaged squared residuals between the inferred field and the model field. Then, the parameters were used in the filter to infer the ocean-generated magnetic field that was initially added to the “measurements.” The inferred signal, although spatially corrupted and having a smaller magnitude (60% of the magnitude of the initial signal), indicated the presence of magnetic anomalies within the Southern Ocean. The technique was then applied to CHAMP geomagnetic measurements. The result of filtering was clear magnetic anomalies within the Southern Ocean with a spatial character that were close to what models of the ocean-generated magnetic field provided. The magnitude of the inferring signal was 5 nT, the corrected values were 7-8 nT, 1-2 nT larger than the modeled field magnitude. To compare the temporal variability of the inferred field with the variability of sea surface height, ten 10° by 10° areas were selected within the Southern Ocean and the root-mean-square of both SSH and the magnetic field were computed for each area. A comparison of the results indicated a

  17. Raman Based Dispersive Systems for Short Pulse Generation and Optical Signal Processing

    NASA Astrophysics Data System (ADS)

    Kalyoncu, Salih Kagan

    Spatiotemporal dispersive systems have been widely utilized for nonlinear optics and optical signal processing applications. This thesis is dedicated to the investigation of dispersive and nonlinear properties of optical fibers, temporal dispersion for real time operation and spatially dispersed pulse shaping systems. In particular, this thesis is focused on Raman based dispersive systems based on such promising techniques as dispersion management, photonic time stretching and space-to-wavelength mapping for synchronous pulse generation and all-optical RF arbitrary waveform generation incorporated with mature MEMS technology. The first part of this thesis discusses a novel technique of using dispersion managed system for synchronous first and second order pulsed Raman lasers that can achieve frequency spacing of up to 1000 cm-1, which are widely utilized for CARS microscopy applications. In particular, I focus on analytical and numerical analysis of pulsed stability derived for Raman lasers by using dispersion-managed telecom fibers and pumping at near 1530 nm telecom wavelengths. I show the evolution of the first and second order Stokes signals at the output for different peak pump power and the net anomalous dispersion combinations. I determine the stability condition for dispersion-managed synchronous Raman lasers up to second order. In the second part of the thesis, the noise performance of the amplified time stretched systems is investigated. Amplified time stretched systems enabling real time applications such as high-speed analog-to-digital converters, RF arbitrary waveform generation and dispersive imaging are performance limited by the noise cumulated in the system. In particular, I analyze the noise performance and hence the effective number of bits (ENOB) performance of time stretch ADCs with distributed and lumped amplifications. I estimate that distributed amplification in time stretch system with >10GHz analog bandwidth exhibit up to 16dB higher SNR

  18. Effect of fragment-based perturbations on the disaggregation performance of a VLB streamflow generator

    NASA Astrophysics Data System (ADS)

    Ndiritu, J. G.

    In order to adequately incorporate measures of reliability in water resources planning, synthetically generated streamflow sequences are often applied in addition to historic time series. In spite of decades of research on parametric stochastic generation methods, their practical use has not been prevalent and some practitioners have been applying much simpler non-parametric bootstrap methods. The traditional bootstrap however does not provide any flows other than those in the historic record and consequently obtains synthetic sequences of low variability. This considerably limits its value as an effective stochastic generator. The Variable Length Block (VLB) bootstrap was recently developed to get rid of this limitation and to enable a more realistic replication of multi-annual flow variability by using blocks of variable length. VLB replicates annual and monthly statistics reasonably but over-estimates the minimum monthly flows and also tends to over-estimate the skewness of monthly flows. VLB also has a tendency to under-estimate serial correlation towards the middle of the year and to over-estimate correlation closer to the end and the beginning of the year. This study presents an attempt to remove these deficiencies of the VLB disaggregation scheme. The disaggregation uses a weighted average of historic fragments (monthly flow/annual flow) obtained from historic matching years with perturbations superimposed to counter the smoothing effect of averaging. The perturbations are subjectively obtained from a triangular distribution and perturbations derived to specifically recover the monthly flow structure (after smoothing) are tried out in the new scheme. These perturbations are obtained as weighted difference of pairs of fragments from historic matching years. Disaggregation using these perturbations is tested on a 5-site stochastic data generation problem. Sixty-eight years of naturalized monthly flows are used and 101 synthetic sequences are generated

  19. High yield neutron generator based on a high-current gasdynamic electron cyclotron resonance ion source

    NASA Astrophysics Data System (ADS)

    Skalyga, V.; Izotov, I.; Golubev, S.; Sidorov, A.; Razin, S.; Strelkov, A.; Tarvainen, O.; Koivisto, H.; Kalvas, T.

    2015-09-01

    In present paper, an approach for high yield compact D-D neutron generator based on a high current gasdynamic electron cyclotron resonance ion source is suggested. Results on dense pulsed deuteron beam production with current up to 500 mA and current density up to 750 mA/cm2 are demonstrated. Neutron yield from D2O and TiD2 targets was measured in case of its bombardment by pulsed 300 mA D+ beam with 45 keV energy. Neutron yield density at target surface of 109 s-1 cm-2 was detected with a system of two 3He proportional counters. Estimations based on obtained experimental results show that neutron yield from a high quality TiD2 target bombarded by D+ beam demonstrated in present work accelerated to 100 keV could reach 6 × 1010 s-1 cm-2. It is discussed that compact neutron generator with such characteristics could be perspective for a number of applications like boron neutron capture therapy, security systems based on neutron scanning, and neutronography.

  20. Using Python to generate AHPS-based precipitation simulations over CONUS using Amazon distributed computing

    NASA Astrophysics Data System (ADS)

    Machalek, P.; Kim, S. M.; Berry, R. D.; Liang, A.; Small, T.; Brevdo, E.; Kuznetsova, A.

    2012-12-01

    We describe how the Climate Corporation uses Python and Clojure, a language impleneted on top of Java, to generate climatological forecasts for precipitation based on the Advanced Hydrologic Prediction Service (AHPS) radar based daily precipitation measurements. A 2-year-long forecasts is generated on each of the ~650,000 CONUS land based 4-km AHPS grids by constructing 10,000 ensembles sampled from a 30-year reconstructed AHPS history for each grid. The spatial and temporal correlations between neighboring AHPS grids and the sampling of the analogues are handled by Python. The parallelization for all the 650,000 CONUS stations is further achieved by utilizing the MAP-REDUCE framework (http://code.google.com/edu/parallel/mapreduce-tutorial.html). Each full scale computational run requires hundreds of nodes with up to 8 processors each on the Amazon Elastic MapReduce (http://aws.amazon.com/elasticmapreduce/) distributed computing service resulting in 3 terabyte datasets. We further describe how we have productionalized a monthly run of the simulations process at full scale of the 4km AHPS grids and how the resultant terabyte sized datasets are handled.

  1. Accelerating the Next Generation Long Read Mapping with the FPGA-Based System.

    PubMed

    Chen, Peng; Wang, Chao; Li, Xi; Zhou, Xuehai

    2014-01-01

    To compare the newly determined sequences against the subject sequences stored in the databases is a critical job in the bioinformatics. Fortunately, recent survey reports that the state-of-the-art aligners are already fast enough to handle the ultra amount of short sequence reads in the reasonable time. However, for aligning the long sequence reads (>400 bp) generated by the next generation sequencing (NGS) technology, it is still quite inefficient with present aligners. Furthermore, the challenge becomes more and more serious as the lengths and the amounts of the sequence reads are both keeping increasing with the improvement of the sequencing technology. Thus, it is extremely urgent for the researchers to enhance the performance of the long read alignment. In this paper, we propose a novel FPGA-based system to improve the efficiency of the long read mapping. Compared to the state-of-the-art long read aligner BWA-SW, our accelerating platform could achieve a high performance with almost the same sensitivity. Experiments demonstrate that, for reads with lengths ranging from 512 up to 4,096 base pairs, the described system obtains a 10x -48x speedup for the bottleneck of the software. As to the whole mapping procedure, the FPGA-based platform could achieve a 1.8x -3:3x speedup versus the BWA-SW aligner, reducing the alignment cycles from weeks to days. PMID:26356857

  2. High yield neutron generator based on a high-current gasdynamic electron cyclotron resonance ion source

    SciTech Connect

    Skalyga, V.; Sidorov, A.; Izotov, I.; Golubev, S.; Razin, S.; Strelkov, A.; Tarvainen, O.; Koivisto, H.; Kalvas, T.

    2015-09-07

    In present paper, an approach for high yield compact D-D neutron generator based on a high current gasdynamic electron cyclotron resonance ion source is suggested. Results on dense pulsed deuteron beam production with current up to 500 mA and current density up to 750 mA/cm{sup 2} are demonstrated. Neutron yield from D{sub 2}O and TiD{sub 2} targets was measured in case of its bombardment by pulsed 300 mA D{sup +} beam with 45 keV energy. Neutron yield density at target surface of 10{sup 9} s{sup −1} cm{sup −2} was detected with a system of two {sup 3}He proportional counters. Estimations based on obtained experimental results show that neutron yield from a high quality TiD{sub 2} target bombarded by D{sup +} beam demonstrated in present work accelerated to 100 keV could reach 6 × 10{sup 10} s{sup −1} cm{sup −2}. It is discussed that compact neutron generator with such characteristics could be perspective for a number of applications like boron neutron capture therapy, security systems based on neutron scanning, and neutronography.

  3. Physics-Based Predictive Simulation Models for Earthquake Generation at Plate Boundaries

    NASA Astrophysics Data System (ADS)

    Matsu'Ura, M.

    2002-12-01

    In the last decade there has been great progress in the physics of earthquake generation; that is, the introduction of laboratory-based fault constitutive laws as a basic equation governing earthquake rupture and the quantitative description of tectonic loading driven by plate motion. Incorporating a fault constitutive law into continuum mechanics, we can develop a physics-based_@simulation model for the entire earthquake generation process. For realistic simulation of earthquake generation, however, we need a very large, high-speed computer system. In Japan, fortunately, the Earth Simulator, which is a high performance, massively parallel-processing computer system with 10 TB memories and 40 TFLOPS peak speed, has been completed. The completion of the Earth Simulator and advance in numerical simulation methodology are bringing our vision within reach. In general, the earthquake generation cycle consists of tectonic loading due to relative plate motion, quasi-static rupture nucleation, dynamic rupture propagation and stop, and restoration of fault strength. The basic equations governing the entire earthquake generation cycle consists of an elastic/viscoelastic slip-response function that relates fault slip to shear stress change and a fault constitutive law that prescribes change in shear strength with fault slip and contact time. The shear stress and the shear strength are related with each other through the boundary conditions on the fault. The driving force of this system is observed relative plate motion. The system to describe the earthquake generation cycle is conceptually quite simple. The complexity in practical modelling mainly comes from complexity in structure of the real earth. Since 1998 our group have conducted the Crustal Activity Modelling Program (CAMP), which is one of the three main programs composing the Solid Earth Simulator project. The aim of CAMP is to develop a physics-based predictive simulation model for the entire earthquake generation

  4. Uncooled resonant infrared detector based on aluminum nitride piezoelectric film through charge generations and lattice absorptions

    NASA Astrophysics Data System (ADS)

    Ang, W. C.; Kropelnicki, P.; Zhu, Y.; Randles, A. B.; Gu, Y. A.; Leong, K. C.; Tan, C. S.

    2014-05-01

    This Letter demonstrates an aluminum nitride (AlN) based uncooled resonant infrared (IR) detector utilizing the photo-sensitive and piezoelectric properties of polycrystalline AlN. The AlN Lamb wave mode resonator is found responsive to IR illuminations by showing a decrease in the S21 magnitude instead of a resonant frequency shift. A -0.08 dB shift of S21 magnitude was observed for an IR incident power of 647 nW, which translates to a responsivity of 124 kdB/W. Photoresponse is proposed for the IR sensing mechanism through additional charge carriers generation rather than thermal effects.

  5. Case-Based Learning: A Formal Approach to Generate Health Case Studies from Electronic Healthcare Records.

    PubMed

    Ricci, Fabrizio L; Consorti, Fabrizio; Gentile, Manuel; Messineo, Linda; La Guardia, Dario; Arrigo, Marco; Allegra, Mario

    2016-01-01

    There is an increasing social pressure to train medical students with a level of competency sufficient to face clinical practice already at the end of their curriculum. The case-based learning (CBL) is an efficient teaching method to prepare students for clinical practice through the use of real or realistic clinical cases. In this regard, the Electronic Healthcare Record (EHR) could be a good source of real patient stories that can be transformed into educative cases. In this paper a formal approach to generate Health Case Studies from EHR is defined. PMID:27071887

  6. Panorama of new generation of accelerator based short wavelength coherent light sources

    NASA Astrophysics Data System (ADS)

    Couprie, M. E.

    2015-12-01

    The newly developed intense short wavelength light sources (from Extreme Ultra-Violet (EUV) to X-rays) have open the path to the exploration of matter for revealing structures and electronic processes and for following their evolution in time. After drawing the panorama of existing accelerator based short wavelength light sources, the new trends of evolution of short wavelengths FEL are described, with some illustrations with the example of the LUNEX5 (free electron Laser a New accelerator for the Exploitation of X-ray radiation of 5th generation) demonstrator project of advanced compact Free Electron Laser.

  7. A software-based controller for generation of synchronized pulses for use with rotating machinery

    NASA Astrophysics Data System (ADS)

    Zurloye, Axel O.

    1989-08-01

    An IBM PC/AT based software package was developed to synchrotronize test equipment with rotating machinery. Up to eight outputs can be controlled independently. The pulse sequences can be as long as 254 shaft encoder revolutions and repeat until terminated. Unlike most purpose-built controllers, this software package is highly flexible. Complicated pulse sequences are easily generated and can quickly be modified using the built-in editor or a standard text editor. While the software requires a dedicated computer, implementation is easier and more cost effective than construction of a purpose-built controller.

  8. Tight bound on coherent-state-based entanglement generation over lossy channels

    SciTech Connect

    Azuma, Koji; Sota, Naoya; Koashi, Masato; Imoto, Nobuyuki

    2010-02-15

    The first stage of the hybrid quantum repeaters is entanglement generation based on transmission of pulses in coherent states over a lossy channel. Protocols to make entanglement with only one type of error are favorable for rendering subsequent entanglement distillation efficient. Here we provide the tight upper bound on performances of these protocols that is determined only by the channel loss. In addition, we show that this bound is achievable by utilizing a proposed protocol [K. Azuma, N. Sota, R. Namiki, S. K. Oezdemir, T. Yamamoto, M. Koashi, and N. Imoto, Phys. Rev. A 80, 060303(R) (2009)] composed of a simple combination of linear optical elements and photon-number-resolving detectors.

  9. The generation of infrared and ultraviolet astronomical data bases and retrieval systems

    NASA Technical Reports Server (NTRS)

    Mead, J. M.

    1985-01-01

    Observations with the Infrared Astronomy Satellite (IRAS) and with the International Ultraviolet Explorer (IUE) satellite have stimulated the need for machine-readable data bases at infrared and ultraviolet wavelengths along with associated software. This paper describes the generation of three such data sets at the Astronomical Data Center (ADC) of the NASA-Goddard Space Flight Center (GSFC): the Catalog of Infrared Observations, the Combined List of Astronomical Sources, and the Bibliographical Index of Objects Observed by IUE 1978-82. The discussion is divided by spectral regime and includes summaries of the data products developed in each category.

  10. Compact solar autoclave based on steam generation using broadband light-harvesting nanoparticles

    PubMed Central

    Neumann, Oara; Feronti, Curtis; Neumann, Albert D.; Dong, Anjie; Schell, Kevin; Lu, Benjamin; Kim, Eric; Quinn, Mary; Thompson, Shea; Grady, Nathaniel; Nordlander, Peter; Oden, Maria; Halas, Naomi J.

    2013-01-01

    The lack of readily available sterilization processes for medicine and dentistry practices in the developing world is a major risk factor for the propagation of disease. Modern medical facilities in the developed world often use autoclave systems to sterilize medical instruments and equipment and process waste that could contain harmful contagions. Here, we show the use of broadband light-absorbing nanoparticles as solar photothermal heaters, which generate high-temperature steam for a standalone, efficient solar autoclave useful for sanitation of instruments or materials in resource-limited, remote locations. Sterilization was verified using a standard Geobacillus stearothermophilus-based biological indicator. PMID:23836642

  11. Compact solar autoclave based on steam generation using broadband light-harvesting nanoparticles.

    PubMed

    Neumann, Oara; Feronti, Curtis; Neumann, Albert D; Dong, Anjie; Schell, Kevin; Lu, Benjamin; Kim, Eric; Quinn, Mary; Thompson, Shea; Grady, Nathaniel; Nordlander, Peter; Oden, Maria; Halas, Naomi J

    2013-07-16

    The lack of readily available sterilization processes for medicine and dentistry practices in the developing world is a major risk factor for the propagation of disease. Modern medical facilities in the developed world often use autoclave systems to sterilize medical instruments and equipment and process waste that could contain harmful contagions. Here, we show the use of broadband light-absorbing nanoparticles as solar photothermal heaters, which generate high-temperature steam for a standalone, efficient solar autoclave useful for sanitation of instruments or materials in resource-limited, remote locations. Sterilization was verified using a standard Geobacillus stearothermophilus-based biological indicator. PMID:23836642

  12. Monolithic solid oxide fuel cell technology advancement for coal- based power generation. Quarterly report, December 1991

    SciTech Connect

    Not Available

    1992-01-15

    The program is conducted by a team consisting of AiResearch Los Angeles Division of Allied-Signal Aerospace Company and Argonne National Laboratory (ANL). The objective of the program is to advance materials and fabrication methodologies to develop a monolithic solid oxide fuel cell (MSOFC) system capable of meeting performance, life, and cost goals for coal-based power generation. The program focuses on materials research and development, fabrication process development, cell/stack performance testing and characterization, cost and system analysis, and quality development.

  13. Monolithic solid oxide fuel cell technology advancement for coal- based power generation

    SciTech Connect

    Not Available

    1992-01-15

    The program is conducted by a team consisting of AiResearch Los Angeles Division of Allied-Signal Aerospace Company and Argonne National Laboratory (ANL). The objective of the program is to advance materials and fabrication methodologies to develop a monolithic solid oxide fuel cell (MSOFC) system capable of meeting performance, life, and cost goals for coal-based power generation. The program focuses on materials research and development, fabrication process development, cell/stack performance testing and characterization, cost and system analysis, and quality development.

  14. Imaging molecular structure with Stokes-polarimeter based second harmonic generation microscopy

    NASA Astrophysics Data System (ADS)

    Mazumder, Nirmal; Qiu, Jianjun; Hu, Chih-Wei; Kao, Fu-Jen

    2013-02-01

    We analyzed the polarization states of second harmonic generation (SHG) signals from starch granules and type I collagen through a four-channel photon counting based Stokes-polarimeter. The 2D SHG images of samples are reconstructed using various polarization parameters, such as the degree of polarization (DOP), the degree of linear polarization (DOLP), the degree of circular polarization (DOCP), as well as the anisotropy from the acquired Stokes parameters. Furthermore, we have demonstrated that the polarization parameters are changes at different input polarizations and focusing depths.

  15. Ultralow phase noise microwave generation with an Er:fiber-based optical frequency divider.

    PubMed

    Quinlan, Franklyn; Fortier, Tara M; Kirchner, Matthew S; Taylor, Jennifer A; Thorpe, Michael J; Lemke, Nathan; Ludlow, Andrew D; Jiang, Yanyi; Diddams, Scott A

    2011-08-15

    We present an optical frequency divider based on a 200 MHz repetition rate Er:fiber mode-locked laser that, when locked to a stable optical frequency reference, generates microwave signals with absolute phase noise that is equal to or better than cryogenic microwave oscillators. At 1 Hz offset from a 10 GHz carrier, the phase noise is below -100 dBc/Hz, limited by the optical reference. For offset frequencies >10 kHz, the phase noise is shot noise limited at -145 dBc/Hz. An analysis of the contribution of the residual noise from the Er:fiber optical frequency divider is also presented. PMID:21847227

  16. Radiolytic gas generation from cement-based waste hosts for DOE low-level radioactive wastes

    SciTech Connect

    Dole, L.R.; Friedman, H.A.

    1986-01-01

    Using cement-based immobilization binders with simulated radioactive waste containing sulfate, nitrate, nitrite, phosphate, and fluoride anions, the gamma- and alpha-radiolytic gas generation factors (G/sub t/, molecules/100 eV) and gas compositions were measured on specimens of cured grouts. These tests studied the effects of; (1) waste composition; (2) the sample surface-to-volume ratio; (3) the waste slurry particle size; and (4) the water content of the waste host formula. The radiolysis test vessels were designed to minimize the ''dead'' volume and to simulate the configuration of waste packages.

  17. Fault diagnosing system of steam generator for nuclear power plant based on fuzzy neural networks

    NASA Astrophysics Data System (ADS)

    Fu, Ming-Yu; Bian, Xin-Qian; Shi, Ji

    2002-06-01

    All kinds of reasons are analysed in theory and a fault repository combined with local expert experiences is established according to the structure and the operation characteristic of steam generator in this paper. At the same time, Kohonen algorithm is used for fault diagnoses system based on fuzzy neural networks. Fuzzy arithmetic is inducted into neural networks to solve uncertain diagnosis induced by uncertain knowledge. According to its self-association in the course of default diagnosis, the system is provided with non-supervise, self-organizing, self-learning, and has strong cluster ability and fast cluster velocity.

  18. Generation of a novel phase-space-based cylindrical dose kernel for IMRT optimization

    SciTech Connect

    Zhong Hualiang; Chetty, Indrin J.

    2012-05-15

    Purpose: Improving dose calculation accuracy is crucial in intensity-modulated radiation therapy (IMRT). We have developed a method for generating a phase-space-based dose kernel for IMRT planning of lung cancer patients. Methods: Particle transport in the linear accelerator treatment head of a 21EX, 6 MV photon beam (Varian Medical Systems, Palo Alto, CA) was simulated using the EGSnrc/BEAMnrc code system. The phase space information was recorded under the secondary jaws. Each particle in the phase space file was associated with a beamlet whose index was calculated and saved in the particle's LATCH variable. The DOSXYZnrc code was modified to accumulate the energy deposited by each particle based on its beamlet index. Furthermore, the central axis of each beamlet was calculated from the orientation of all the particles in this beamlet. A cylinder was then defined around the central axis so that only the energy deposited within the cylinder was counted. A look-up table was established for each cylinder during the tallying process. The efficiency and accuracy of the cylindrical beamlet energy deposition approach was evaluated using a treatment plan developed on a simulated lung phantom. Results: Profile and percentage depth doses computed in a water phantom for an open, square field size were within 1.5% of measurements. Dose optimized with the cylindrical dose kernel was found to be within 0.6% of that computed with the nontruncated 3D kernel. The cylindrical truncation reduced optimization time by approximately 80%. Conclusions: A method for generating a phase-space-based dose kernel, using a truncated cylinder for scoring dose, in beamlet-based optimization of lung treatment planning was developed and found to be in good agreement with the standard, nontruncated scoring approach. Compared to previous techniques, our method significantly reduces computational time and memory requirements, which may be useful for Monte-Carlo-based 4D IMRT or IMAT treatment planning.

  19. DTM generation using land cover classification based on low density lidar data

    NASA Astrophysics Data System (ADS)

    Koma, Zsófia; Zlinszky, András

    2014-05-01

    While the point density of local LIDAR surveys continues to increase, most regional or national LIDAR campaigns are carried out with medium or low density, and have the main purpose of DTM generation. Many different point selection and filtering algorithms are already established. Depending on land cover and vegetation, some perform better than others, but no algorithm exists that works perfectly for all types of land cover. Therefore, our method applies several different DTM generation and filtering algorithms for different spatial units depending on their land cover and vegetation. Land cover and vegetation are mapped based on the original raw LIDAR dataset. Two discrete echo airborne LIDAR measurements were used, one with 1 point/m2 and a larger area with 0.4 point/m2 density. The datasets were used together for DTM generation after relative georeferencing by strip adjustment. We defined several land cover categories depending on how they influence vertical distribution of LIDAR points: buildings, waterways, grasslands, crop fields, wetlands, and forests. The study area was classified to these categories based on a decision tree algorithm using parameters calculated from the original LIDAR dataset (sigmaZ, reflectance, aspect, slope, echoratio, roughness), at resolution identical to the output DTM. For the points within spatial units belonging to each of these categories, we implemented different filtering and interpolation methods to select ground points. For buildings, roof and wall points were removed and the resulting gap filled by interpolated based on the neighbouring data. In forests we calculated a first smooth approximate surface based on minimum points every 10 meter cells. We calculated a residual value for every point of this surface in this class. Then we analysed the point cloud based on residuals value and made an optimum threshold which classified the datasets for non-ground and ground points. In wetlands and croplands, the point height range

  20. Generation of broad ion beams in sources based on Penning system with nonequipotential cathode

    NASA Astrophysics Data System (ADS)

    Nikulin, S. P.; Chichigin, D. F.; Tretnikov, P. V.

    2004-05-01

    A method of generation of uniform plasma in low-pressure glow discharges with oscillating electrons has been developed. The method is based on the separation of the cathode into several elements, with potentials of the parts being different. Experimental results show that the use of the nonequipotential cathode in the Penning system enables effective control of spatial plasma distribution. This makes it possible to obtain nearly uniform ion emission current distributions and to form broad beams. Two variants of ion sources are under investigation. The first source generates low energy (˜1 keV) ions, which are often used for cleaning of surfaces. A treated target plays a role in one of the cathodes and acceleration of ions is realized directly in the cathode sheath. The required level of ion energy is provided by applying a corresponding voltage between the target and the anode of the system. The second source generates an ion beam with higher (several tens of keV) energy. Accelerating-decelerating ion optics is used in this variant. The efficiency of ion extraction, defined as the ratio of beam and discharge currents, is equal to 30%.

  1. Photonic generation of linearly chirped millimeter wave based on comb-spacing tunable optical frequency comb

    NASA Astrophysics Data System (ADS)

    Xia, Zongyang; Xie, Weilin; Sun, Dongning; Shi, Hongxiao; Dong, Yi; Hu, Weisheng

    2013-12-01

    We demonstrated a photonic approach to generate a phase-continuous frequency-linear-chirped millimeter-wave (mm-wave) signal with high linearity based on continuous-wave phase modulated optical frequency comb and cascaded interleavers. Through linearly sweeping the frequency of the radio frequency (RF) driving signal, high-order frequency-linear-chirped optical comb lines are generated and then extracted by the cascaded interleavers. By beating the filtered high-order comb lines, center frequency and chirp range multiplied linear-chirp microwave signals are generated. Frequency doubled and quadrupled linear-chirp mm-wave signals of range 48.6 to 52.6 GHz and 97.2 to 105.2 GHz at chirp rates of 133.33 and 266.67 GHz/s are demonstrated with the ±1st and ±2nd optical comb lines, respectively, while the RF driving signal is of chirp range 24.3 to 26.3 GHz and chirp time 30 ms.

  2. All-solid-state repetitive semiconductor opening switch-based short pulse generator

    NASA Astrophysics Data System (ADS)

    Ding, Zhenjie; Hao, Qingsong; Hu, Long; Su, Jiancang; Liu, Guozhi

    2009-09-01

    The operating characteristics of a semiconductor opening switch (SOS) are determined by its pumping circuit parameters. SOS is still able to cut off the current when pumping current duration falls to the order of tens of nanoseconds and a short pulse forms simultaneously in the output load. An all-solid-state repetitive SOS-based short pulse generator (SPG100) with a three-level magnetic pulse compression unit was successfully constructed. The generator adopts magnetic pulse compression unit with metallic glass and ferrite cores, which compresses a 600 V, 10 μs primary pulse into short pulse with forward pumping current of 825 A, 60 ns and reverse pumping current of 1.3 kA, 30 ns. The current is sent to SOS in which the reverse pumping current is interrupted. The generator is capable of providing a pulse with the voltage of 120 kV and duration of 5-6 ns while output load being 125 Ω. The highest repetition rate is up to 1 kHz.

  3. Power generation from base excitation of a Kevlar composite beam with ZnO nanowires

    NASA Astrophysics Data System (ADS)

    Malakooti, Mohammad H.; Hwang, Hyun-Sik; Sodano, Henry A.

    2015-04-01

    One-dimensional nanostructures such as nanowires, nanorods, and nanotubes with piezoelectric properties have gained interest in the fabrication of small scale power harvesting systems. However, the practical applications of the nanoscale materials in structures with true mechanical strengths have not yet been demonstrated. In this paper, piezoelectric ZnO nanowires are integrated into the fiber reinforced polymer composites serving as an active phase to convert the induced strain energy from ambient vibration into electrical energy. Arrays of ZnO nanowires are grown vertically aligned on aramid fibers through a low-cost hydrothermal process. The modified fabrics with ZnO nanowires whiskers are then placed between two carbon fabrics as the top and the bottom electrodes. Finally, vacuum resin transfer molding technique is utilized to fabricate these multiscale composites. The fabricated composites are subjected to a base excitation using a shaker to generate charge due to the direct piezoelectric effect of ZnO nanowires. Measuring the generated potential difference between the two electrodes showed the energy harvesting application of these multiscale composites in addition to their superior mechanical properties. These results propose a new generation of power harvesting systems with enhanced mechanical properties.

  4. Parasitic effects in superconducting quantum interference device-based radiation comb generators

    NASA Astrophysics Data System (ADS)

    Bosisio, R.; Giazotto, F.; Solinas, P.

    2015-12-01

    We study several parasitic effects on the implementation of a Josephson radiation comb generator based on a dc superconducting quantum interference device (SQUID) driven by an external magnetic field. This system can be used as a radiation generator similarly to what is done in optics and metrology, and allows one to generate up to several hundreds of harmonics of the driving frequency. First we take into account how the assumption of a finite loop geometrical inductance and junction capacitance in each SQUID may alter the operation of the devices. Then, we estimate the effect of imperfections in the fabrication of an array of SQUIDs, which is an unavoidable source of errors in practical situations. We show that the role of the junction capacitance is, in general, negligible, whereas the geometrical inductance has a beneficial effect on the performance of the device. The errors on the areas and junction resistance asymmetries may deteriorate the performance, but their effect can be limited to a large extent by a suitable choice of fabrication parameters.

  5. A compact bipolar pulse-forming network-Marx generator based on pulse transformers

    NASA Astrophysics Data System (ADS)

    Zhang, Huibo; Yang, Jianhua; Lin, Jiajin; Yang, Xiao

    2013-11-01

    A compact bipolar pulse-forming network (PFN)-Marx generator based on pulse transformers is presented in this paper. The high-voltage generator consisted of two sets of pulse transformers, 6 stages of PFNs with ceramic capacitors, a switch unit, and a matched load. The design is characterized by the bipolar pulse charging scheme and the compact structure of the PFN-Marx. The scheme of bipolar charging by pulse transformers increased the withstand voltage of the ceramic capacitors in the PFNs and decreased the number of the gas gap switches. The compact structure of the PFN-Marx was aimed at reducing the parasitic inductance in the generator. When the charging voltage on the PFNs was 35 kV, the matched resistive load of 48 Ω could deliver a high-voltage pulse with an amplitude of 100 kV. The full width at half maximum of the load pulse was 173 ns, and its rise time was less than 15 ns.

  6. Generation of triangular waveforms based on a microwave photonic filter with negative coefficient.

    PubMed

    Li, Wei; Wang, Wen Ting; Sun, Wen Hui; Wang, Wei Yu; Zhu, Ning Hua

    2014-06-16

    We report a novel approach to generating full-duty-cycle triangular waveforms based on a microwave photonic filter (MPF) with negative coefficient. It is known that the Fourier series expansion of a triangular waveform has only odd-order harmonics. In this work, the undesired even-order harmonics are suppressed by the MPF that has a periodic transmission response. A triangular waveform at fundamental frequency can be generated by setting the bias of a Mach-Zehnder modulator (MZM) at quadrature point. However, it is found that a broadband 90° microwave phase shifter has to be used after photodetection to adjust the phases of odd-order harmonics. Alternatively, a frequency doubling triangular waveform can be generated by setting the bias of the MZM at maximum or minimum transmission point. This approach is more promising because the broadband microwave phase shifter is no longer required in this case but it is more power consuming. The proposed approach is theoretically analyzed and experimentally verified. PMID:24977593

  7. A small-signal generator based on a multi-layer graphene/molybdenum disulfide heterojunction

    SciTech Connect

    Tan, Zhen; Tian, He; Feng, Tingting; Zhao, Lianfeng; Xie, Dan; Yang, Yi; Xiao, Lei; Wang, Jing; Ren, Tian-Ling E-mail: JunXu@tsinghua.edu.cn; Xu, Jun E-mail: JunXu@tsinghua.edu.cn

    2013-12-23

    In this work, we fabricate a heterojunction small-signal generator (HSSG) based on a graphene-molybdenum disulfide (MoS{sub 2}) heterojunction. The HSSG is fundamentally different from any analog device developed previously. The HSSG is composed of two quasi-2D heterojunctions and has three terminals named injector (I), recombinator (R), and generator (G). MoS{sub 2} serves as I and G, and graphene works as R in the HSSG. The scale coefficient (β = I{sub G}/I{sub R}) of the HSSG is 1.14 × 10{sup −4} (V{sub IG, IR} = 0.2 V) to 1.95 × 10{sup −4} (V{sub IG, IR} = 1 V). The current generated from G could be as low as pA scale, which reveals the good performance of the HSSG.

  8. A new class of scalable parallel pseudorandom number generators based on Pohlig-Hellman exponentiation ciphers

    NASA Astrophysics Data System (ADS)

    Beale, Paul

    2015-03-01

    We propose a new class of pseudorandom number generators based on Pohlig-Hellman exponentiation ciphers. The method generates uniform pseudorandom streams by encrypting simple sequences of short integer messages into ciphertexts by exponentiation modulo prime numbers. The advantages of the method are: the method is trivially parallelizable by parameterization with each pseudorandom number generator derived from an independent prime modulus, the method is fully scalable on massively parallel computing clusters due to the large number of primes available for each implementation, the seeding and initialization of the independent streams is simple, the method requires only a few integer multiply-mod operations per pseudorandom number, the state of each instance is defined by only a few integer values, the period of each instance is different, and the method passes a battery of intrastream and interstream correlation tests using up to 1013 pseudorandom numbers per test. We propose an implementation using 32-bit prime moduli with small exponents that require only a few 64-bit multiply-mod operations that can be executed directly in hardware. The 32-bit implementation we propose has millions of possible instances, all with periods greater than 1018. Supported by NSF CNS-082179.

  9. A compact bipolar pulse-forming network-Marx generator based on pulse transformers.

    PubMed

    Zhang, Huibo; Yang, Jianhua; Lin, Jiajin; Yang, Xiao

    2013-11-01

    A compact bipolar pulse-forming network (PFN)-Marx generator based on pulse transformers is presented in this paper. The high-voltage generator consisted of two sets of pulse transformers, 6 stages of PFNs with ceramic capacitors, a switch unit, and a matched load. The design is characterized by the bipolar pulse charging scheme and the compact structure of the PFN-Marx. The scheme of bipolar charging by pulse transformers increased the withstand voltage of the ceramic capacitors in the PFNs and decreased the number of the gas gap switches. The compact structure of the PFN-Marx was aimed at reducing the parasitic inductance in the generator. When the charging voltage on the PFNs was 35 kV, the matched resistive load of 48 Ω could deliver a high-voltage pulse with an amplitude of 100 kV. The full width at half maximum of the load pulse was 173 ns, and its rise time was less than 15 ns. PMID:24289423

  10. All-solid-state repetitive semiconductor opening switch-based short pulse generator.

    PubMed

    Ding, Zhenjie; Hao, Qingsong; Hu, Long; Su, Jiancang; Liu, Guozhi

    2009-09-01

    The operating characteristics of a semiconductor opening switch (SOS) are determined by its pumping circuit parameters. SOS is still able to cut off the current when pumping current duration falls to the order of tens of nanoseconds and a short pulse forms simultaneously in the output load. An all-solid-state repetitive SOS-based short pulse generator (SPG100) with a three-level magnetic pulse compression unit was successfully constructed. The generator adopts magnetic pulse compression unit with metallic glass and ferrite cores, which compresses a 600 V, 10 mus primary pulse into short pulse with forward pumping current of 825 A, 60 ns and reverse pumping current of 1.3 kA, 30 ns. The current is sent to SOS in which the reverse pumping current is interrupted. The generator is capable of providing a pulse with the voltage of 120 kV and duration of 5-6 ns while output load being 125 Omega. The highest repetition rate is up to 1 kHz. PMID:19791935

  11. Tunable microwave signal generation based on an Opto-DMD processor and a photonic crystal fiber

    NASA Astrophysics Data System (ADS)

    Wang, Tao; Sang, Xin-Zhu; Yan, Bin-Bin; Ai, Qi; Li, Yan; Chen, Xiao; Zhang, Ying; Chen, Gen-Xiang; Song, Fei-Jun; Zhang, Xia; Wang, Kui-Ru; Yuan, Jin-Hui; Yu, Chong-Xiu; Xiao, Feng; Alameh, Kamal

    2014-06-01

    Frequency-tunable microwave signal generation is proposed and experimentally demonstrated with a dual-wavelength single-longitudinal-mode (SLM) erbium-doped fiber ring laser based on a digital Opto-DMD processor and four-wave mixing (FWM) in a high-nonlinear photonic crystal fiber (PCF). The high-nonlinear PCF is employed for the generation of the FWM to obtain stable and uniform dual-wavelength oscillation. Two different short passive sub-ring cavities in the main ring cavity serve as mode filters to make SLM lasing. The two lasing wavelengths are electronically selected by loading different gratings on the Opto-DMD processor controlled with a computer. The wavelength spacing can be smartly adjusted from 0.165 nm to 1.08 nm within a tuning accuracy of 0.055 nm. Two microwave signals at 17.23 GHz and 27.47 GHz are achieved. The stability of the microwave signal is discussed. The system has the ability to generate a 137.36-GHz photonic millimeter signal at room temperature.

  12. Silicone-based elastic composites able to generate energy on micromechanical impulse

    NASA Astrophysics Data System (ADS)

    Racles, Carmen; Ignat, Mircea; Bele, Adrian; Dascalu, Mihaela; Lipcinski, Daniel; Cazacu, Maria

    2016-08-01

    Elastic composites were prepared based on a polydimethylsiloxane-α,ω-diol (M w = 139 000 g mol‑1), different α,ω-bis(trimethylsiloxy)poly(methylcyanopropyl-methylhexyl-methylhydro)siloxanes as the polar group component and TEOS as a cross-linking agent and silica generator. The resulting materials consisted of polar–nonpolar interconnected networks as matrices which had 7.4 or 9.5 wt% in situ generated silica and contained up to 2.74 wt% CN groups. The films formed were tested for electromechanical response to a micromechanical impulse. It was found that their performance was proportional to their electromechanical sensitivity (β = ε‧/Y, where ε‧ is the dielectric permittivity and Y is Young’s modulus); thus it can be adjusted by their composition, via tailoring the dielectric and mechanical properties. The generated voltage peak-to-peak measured was between 3.75 and 12.3 V mm‑1. The best result for the tested materials (i.e. harvested energy of 460 nJ or energy density of 4.6 μJ cm‑3, as a response to a micro-impulse of 0.017 kg m s‑1) was obtained for a film having ε‧ = 3.6 and Y = 0.19 MPa.

  13. Parasitic effects in superconducting quantum interference device-based radiation comb generators

    SciTech Connect

    Bosisio, R.; Giazotto, F.; Solinas, P.

    2015-12-07

    We study several parasitic effects on the implementation of a Josephson radiation comb generator based on a dc superconducting quantum interference device (SQUID) driven by an external magnetic field. This system can be used as a radiation generator similarly to what is done in optics and metrology, and allows one to generate up to several hundreds of harmonics of the driving frequency. First we take into account how the assumption of a finite loop geometrical inductance and junction capacitance in each SQUID may alter the operation of the devices. Then, we estimate the effect of imperfections in the fabrication of an array of SQUIDs, which is an unavoidable source of errors in practical situations. We show that the role of the junction capacitance is, in general, negligible, whereas the geometrical inductance has a beneficial effect on the performance of the device. The errors on the areas and junction resistance asymmetries may deteriorate the performance, but their effect can be limited to a large extent by a suitable choice of fabrication parameters.

  14. Efficient Image-Vector-Generation Processor for Edge-Based Complementary Feature Representations

    NASA Astrophysics Data System (ADS)

    Yamashita, Naoya; Shibata, Tadashi

    2012-02-01

    A digital processor dedicated to edge-based image vector generation has been developed aiming at real-time image recognition. The processor consists of an on-chip memory and 16 single instruction multiple data (SIMD) processing elements. The capacity of the on-chip memory as well as the overhead for starting the processing have been minimized by introducing a seamless data transferring scheme from memory to processing elements. The 16 SIMD processing elements work together either as accumulators or as shift registers, thus achieving a very efficient generation of two different kinds of feature vector: projected principal-edge distribution (PPED)[3,4] and averaged principal-edge distribution (APED).[5] Concurrent use of these two vectors is shown to be very important for robust image recognition.[5] The chip was fabricated using 0.18-µm complementary metal oxide semiconductor (CMOS) technology and the generation of 64-dimension PPED and APED vectors at 84.7 and 83.9 fps, respectively, from video graphics array (VGA) size images was demonstrated at 62.5 MHz.

  15. Optimization of mask manufacturing rule check constraint for model based assist feature generation

    NASA Astrophysics Data System (ADS)

    Shim, Seongbo; Kim, Young-chang; Chun, Yong-jin; Lee, Seong-Woo; Lee, Suk-joo; Choi, Seong-woon; Han, Woo-sung; Chang, Seong-hoon; Yoon, Seok-chan; Kim, Hee-bom; Ki, Won-tai; Woo, Sang-gyun; Cho, Han-gu

    2008-11-01

    SRAF (sub-resolution assist feature) generation technology has been a popular resolution enhancement technique in photo-lithography past sub-65nm node. It helps to increase the process window, and these are some times called ILT(inverse lithography technology). Also, many studies have been presented on how to determine the best positions of SRAFs, and optimize its size. According to these reports, the generation of SRAF can be formulated as a constrained optimization problem. The constraints are the side lobe suppression and allowable minimum feature size or MRC (mask manufacturing rule check). As we know, bigger SRAF gives better contribution to main feature but susceptible to SRAF side lobe issue. Thus, we finally have no choice but to trade-off the advantages of the ideally optimized mask that contains very complicated SRAF patterns to the layout that has been MRC imposed applied to it. The above dilemma can be resolved by simultaneously using lower dose (high threshold) and cleaning up by smaller MRC. This solution makes the room between threshold (side lobe limitation) and MRC constraint (minimum feature limitation) wider. In order to use smaller MRC restriction without considering the mask writing and inspection issue, it is also appropriate to identify the exact mask writing limitation and find the smart mask constraints that well reflect the mask manufacturability and the e-beam lithography characteristics. In this article, we discuss two main topics on mask optimizations with SRAF. The first topic is on the experimental work to find what behavior of the mask writing ability is in term of several MRC parameters, and we propose more effective MRC constraint for aggressive generation of SRAF. The next topic is on finding the optimum MRC condition in practical case, 3X nm node DRAM contact layer. In fact, it is not easy to encompass the mask writing capability for very complicate real SRAF pattern by using the current MRC constraint based on the only width and

  16. Development of an advanced mobile base for personal mobility and manipulation appliance generation II robotic wheelchair

    PubMed Central

    Wang, Hongwu; Candiotti, Jorge; Shino, Motoki; Chung, Cheng-Shiu; Grindle, Garrett G.; Ding, Dan; Cooper, Rory A.

    2013-01-01

    Background This paper describes the development of a mobile base for the Personal Mobility and Manipulation Appliance Generation II (PerMMA Gen II robotic wheelchair), an obstacle-climbing wheelchair able to move in structured and unstructured environments, and to climb over curbs as high as 8 inches. The mechanical, electrical, and software systems of the mobile base are presented in detail, and similar devices such as the iBOT mobility system, TopChair, and 6X6 Explorer are described. Findings The mobile base of PerMMA Gen II has two operating modes: “advanced driving mode” on flat and uneven terrain, and “automatic climbing mode” during stair climbing. The different operating modes are triggered either by local and dynamic conditions or by external commands from users. A step-climbing sequence, up to 0.2 m, is under development and to be evaluated via simulation. The mathematical model of the mobile base is introduced. A feedback and a feed-forward controller have been developed to maintain the posture of the passenger when driving over uneven surfaces or slopes. The effectiveness of the controller has been evaluated by simulation using the open dynamics engine tool. Conclusion Future work for PerMMA Gen II mobile base is implementation of the simulation and control on a real system and evaluation of the system via further experimental tests. PMID:23820149

  17. Enhanced photocurrent generation in bacteriorhodopsin based bio-sensitized solar cells using gel electrolyte.

    PubMed

    Chellamuthu, Jeganathan; Nagaraj, Pavithra; Chidambaram, Sabari Girisun; Sambandam, Anandan; Muthupandian, Ashokkumar

    2016-09-01

    High purity light sensitive photoactive protein Bacteriorhodopsin (BR) was isolated successfully via a simple two phase extraction technique (ATPS) as an alternate method for the tedious sucrose gradient ultracentrifugation procedure (SGU). Bio sensitized solar cells (BSSCs) were fabricated by the integration of BR into TiO2 (photo anode) with acetamide based gel electrolytes and platinum (photo cathode) as a counter electrode. The structural and photoelectrical behaviours of BR and BSSCs were analyzed by Atomic Force Microscopy, Raman spectroscopy, photocurrent and photovoltage (IV) measurement and electrochemical impedance spectroscopy. The short circuit photocurrent (Jsc) and photoelectric conversion efficiency (η) of acetamide based gel electrolyte (AG) (1.08mAcm(-2), 0.49%) are twice higher than that of traditional triiodide based liquid electrolyte (LE) (0.62mAcm(-2), 0.19%). Also, quasi-Fermi level and lifetime of photogenerated electrons in acetamide based gel electrolyte is about four times higher than that observed in traditional triiodide redox electrolyte. A comparison of the observed results with similar BSSCs made of other natural photoactive protein systems shows that BR as sensitizer has better photovoltaic performance. The enhanced photocurrent generation of the BSSC constructed in our study could be due to the interaction of BR with acetamide based modified poly(ethylene)oxide (PEO) gel electrolyte. PMID:27380296

  18. Neutron generator for BNCT based on high current ECR ion source with gyrotron plasma heating.

    PubMed

    Skalyga, V; Izotov, I; Golubev, S; Razin, S; Sidorov, A; Maslennikova, A; Volovecky, A; Kalvas, T; Koivisto, H; Tarvainen, O

    2015-12-01

    BNCT development nowadays is constrained by a progress in neutron sources design. Creation of a cheap and compact intense neutron source would significantly simplify trial treatments avoiding use of expensive and complicated nuclear reactors and accelerators. D-D or D-T neutron generator is one of alternative types of such sources for. A so-called high current quasi-gasdynamic ECR ion source with plasma heating by millimeter wave gyrotron radiation is suggested to be used in a scheme of D-D neutron generator in the present work. Ion source of that type was developed in the Institute of Applied Physics of Russian Academy of Sciences (Nizhny Novgorod, Russia). It can produce deuteron ion beams with current density up to 700-800 mA/cm(2). Generation of the neutron flux with density at the level of 7-8·10(10) s(-1) cm(-2) at the target surface could be obtained in case of TiD2 target bombardment with deuteron beam accelerated to 100 keV. Estimations show that it is enough for formation of epithermal neutron flux with density higher than 10(9) s(-1) cm(-2) suitable for BNCT. Important advantage of described approach is absence of Tritium in the scheme. First experiments performed in pulsed regime with 300 mA, 45 kV deuteron beam directed to D2O target demonstrated 10(9) s(-1) neutron flux. This value corresponds to theoretical estimations and proofs prospects of neutron generator development based on high current quasi-gasdynamic ECR ion source. PMID:26302662

  19. Perun: The System For Seasonal Crop Yield Forecasting Based On The Crop Model and Weather Generator

    NASA Astrophysics Data System (ADS)

    Dubrovsky, M.; Zalud, Z.; Trnka, M.; Haberle, J.; Pesice, P.

    The main purpose of the computer system PERUN, which is now being developed, is the probabilistic seasonal crop yield forecasting. The crop yields (winter wheat and spring barley in the first step) are simulated by crop model WOFOST. The input daily weather series consist of observed data, which are available in the date of forecast issuance, and synthetic data, which follow up with the observed data till the end of the crop model simulation. The synthetic weather series are generated by stochastic generator Met&Roll conditionally on the seasonal weather forecast. The probabilis- tic forecast is based on multiple crop model runs. To provide the six daily weather characteristics required for crop model simulation (precipitation, solar radiation, max- imum and minimum temperatures, air humidity, wind speed), the previous WGEN- like four-variate version of Met&Roll generator was supplemented by a new module. This module adds wind speed and air humidity (necessary to calculate evapotranspi- ration) using the nearest neighbours resampling from the observed data. Because of the problems with availability and/or accuracy of wind and humidity data, the source code of the WOFOST model was modified and allows now to switch between Penman and Makkink methods of calculating the evapotranspiration (the daily values of wind speed and humidity are not required in the Makkink method). The contribution will address following items: 1) Structure of the PERUN system: components and their inputs and outputs. Modifications to WOFOST crop model and Met&Roll generator will be discussed. 2) Validation of the WOFOST crop model. The accuracy obtained using the Penman and Makkink methods will be compared. 3) Demonstration of the forecast accuracy in dependence on the date of issuance. Acknowledgement: The system PERUN is being developed within the frame of project QC1316 sponsored by the Czech National Agency for Agricultural Research (NAZV).

  20. Using Bayesian Networks for Candidate Generation in Consistency-based Diagnosis

    NASA Technical Reports Server (NTRS)

    Narasimhan, Sriram; Mengshoel, Ole

    2008-01-01

    Consistency-based diagnosis relies heavily on the assumption that discrepancies between model predictions and sensor observations can be detected accurately. When sources of uncertainty like sensor noise and model abstraction exist robust schemes have to be designed to make a binary decision on whether predictions are consistent with observations. This risks the occurrence of false alarms and missed alarms when an erroneous decision is made. Moreover when multiple sensors (with differing sensing properties) are available the degree of match between predictions and observations can be used to guide the search for fault candidates. In this paper we propose a novel approach to handle this problem using Bayesian networks. In the consistency- based diagnosis formulation, automatically generated Bayesian networks are used to encode a probabilistic measure of fit between predictions and observations. A Bayesian network inference algorithm is used to compute most probable fault candidates.

  1. Thermal Optimization of the Heat Exchanger in an Automotive Exhaust-Based Thermoelectric Generator

    NASA Astrophysics Data System (ADS)

    Deng, Y. D.; Liu, X.; Chen, S.; Tong, N. Q.

    2013-07-01

    Recent advances in thermoelectric technologies have made exhaust-based thermoelectric generators (TEGs) promising to recover waste heat. The thermal performance of the heat exchanger in exhaust-based TEGs is studied in this work. In terms of interface temperature and thermal uniformity, the thermal characteristics of heat exchangers with different internal structures, lengths, and materials are discussed. Following computational fluid dynamics simulations, infrared experiments are carried out on a high-performance production engine with a dynamometer. Simulation and experimental results show that a plate-shaped heat exchanger made of brass with fishbone-shaped internal structure and length of 600 mm achieves a relatively ideal thermal performance, which is practically helpful to enhance the thermal performance of the TEG.

  2. Simulated Annealing Based Hybrid Forecast for Improving Daily Municipal Solid Waste Generation Prediction

    PubMed Central

    Song, Jingwei; He, Jiaying; Zhu, Menghua; Tan, Debao; Zhang, Yu; Ye, Song; Shen, Dingtao; Zou, Pengfei

    2014-01-01

    A simulated annealing (SA) based variable weighted forecast model is proposed to combine and weigh local chaotic model, artificial neural network (ANN), and partial least square support vector machine (PLS-SVM) to build a more accurate forecast model. The hybrid model was built and multistep ahead prediction ability was tested based on daily MSW generation data from Seattle, Washington, the United States. The hybrid forecast model was proved to produce more accurate and reliable results and to degrade less in longer predictions than three individual models. The average one-week step ahead prediction has been raised from 11.21% (chaotic model), 12.93% (ANN), and 12.94% (PLS-SVM) to 9.38%. Five-week average has been raised from 13.02% (chaotic model), 15.69% (ANN), and 15.92% (PLS-SVM) to 11.27%. PMID:25301508

  3. A new Pulse-Pattern Generator based on LabVIEW FPGA

    NASA Astrophysics Data System (ADS)

    Ziegler, F.; Beck, D.; Brand, H.; Hahn, H.; Marx, G.; Schweikhard, L.

    2012-07-01

    For the control of experimental sequences composed of triggers, gates and delays a Pulse-Pattern Generator (PPG) has been developed based on a Field Programmable Gate Array (FPGA) addressed in a LabVIEW environment. It allows a highly reproducible timing of measurement procedures by up to 64 individual channels with pulse and delay periods from the nanoseconds to the minutes range. The PPG has been implemented in the context of the development of a new control system for the ClusterTrap setup, an ion storage device for atomic-cluster research, in close contact with the SHIPTRAP and ISOLTRAP collaborations at GSI and CERN, respectively. As the new PPG is not ion-trap specific it can be employed in any experiment based on sequences of triggers, pulses and delays.

  4. All-optical pseudorandom binary sequence generator with TOAD-based D flip-flops

    NASA Astrophysics Data System (ADS)

    Zoiros, K. E.; Das, M. K.; Gayen, D. K.; Maity, H. K.; Chattopadhyay, T.; Roy, J. N.

    2011-09-01

    An all-optical pseudo random binary sequence (PRBS) generator is designed using serially interconnected discrete Terahertz Optical Asymmetric Demultiplexer (TOAD)-based D flip-flops in a configuration exactly like the standard electronic setup. The performance of the circuit is evaluated through numerical simulation, which confirms its feasibility in terms of the choice of the critical parameters. The proposed scheme has been theoretically demonstrated for a 3-bit and 7-bit degree PRBS but can be extended to higher order by means of additional TOAD-based D flip-flops. Thus it can constitute an efficient solution for implementing all-optically a PRBS in an affordable, controllable and realistic manner.

  5. Moving average optimization in digital terrain model generation based on test multibeam echosounder data

    NASA Astrophysics Data System (ADS)

    Maleika, Wojciech

    2015-02-01

    The paper presents a new method of digital terrain model (DTM) estimation based on modified moving average interpolation. There are many methods that can be employed in DTM creation, such as kriging, inverse distance weighting, nearest neighbour and moving average. The moving average method is not as precise as the others; hence, it is not commonly comprised in scientific work. Considering the high accuracy, the relatively low time costs, and the huge amount of measurement data collected by multibeam echosounder, however, the moving average method is definitely one of the most promising approaches. In this study, several variants of this method are analysed. An optimization of the moving average method is proposed based on a new module of selecting neighbouring points during the interpolation process—the "growing radius" approach. Tests experiments performed on various multibeam echosounder datasets demonstrate the high potential of this modified moving average method for improved DTM generation.

  6. A Trustworthy Key Generation Prototype Based on DDR3 PUF for Wireless Sensor Networks

    PubMed Central

    Liu, Wenchao; Zhang, Zhenhua; Li, Miaoxin; Liu, Zhenglin

    2014-01-01

    Secret key leakage in wireless sensor networks (WSNs) is a high security risk especially when sensor nodes are deployed in hostile environment and physically accessible to attackers. With nowadays semi/fully-invasive attack techniques attackers can directly derive the cryptographic key from non-volatile memory (NVM) storage. Physically Unclonable Function (PUF) is a promising technology to resist node capture attacks, and it also provides a low cost and tamper-resistant key provisioning solution. In this paper, we designed a PUF based on double-data-rate SDRAM Type 3 (DDR3) memory by exploring its memory decay characteristics. We also described a prototype of 128-bit key generation based on DDR3 PUF with integrated fuzzy extractor. Due to the wide adoption of DDR3 memory in WSN, our proposed DDR3 PUF technology with high security levels and no required hardware changes is suitable for a wide range of WSN applications. PMID:24984058

  7. Designer Extracellular Matrix Based on DNA-Peptide Networks Generated by Polymerase Chain Reaction.

    PubMed

    Finke, Alexander; Bußkamp, Holger; Manea, Marilena; Marx, Andreas

    2016-08-16

    Cell proliferation and differentiation in multicellular organisms are partially regulated by signaling from the extracellular matrix. The ability to mimic an extracellular matrix would allow particular cell types to be specifically recognized, which is central to tissue engineering. We present a new functional DNA-based material with cell-adhesion properties. It is generated by using covalently branched DNA as primers in PCR. These primers were functionalized by click chemistry with the cyclic peptide c(RGDfK), a peptide that is known to predominantly bind to αvβ3 integrins, which are found on endothelial cells and fibroblasts, for example. As a covalent coating of surfaces, this DNA-based material shows cell-repellent properties in its unfunctionalized state and gains adhesiveness towards specific target cells when functionalized with c(RGDfK). These cells remain viable and can be released under mild conditions by DNase I treatment. PMID:27410200

  8. Simulated annealing based hybrid forecast for improving daily municipal solid waste generation prediction.

    PubMed

    Song, Jingwei; He, Jiaying; Zhu, Menghua; Tan, Debao; Zhang, Yu; Ye, Song; Shen, Dingtao; Zou, Pengfei

    2014-01-01

    A simulated annealing (SA) based variable weighted forecast model is proposed to combine and weigh local chaotic model, artificial neural network (ANN), and partial least square support vector machine (PLS-SVM) to build a more accurate forecast model. The hybrid model was built and multistep ahead prediction ability was tested based on daily MSW generation data from Seattle, Washington, the United States. The hybrid forecast model was proved to produce more accurate and reliable results and to degrade less in longer predictions than three individual models. The average one-week step ahead prediction has been raised from 11.21% (chaotic model), 12.93% (ANN), and 12.94% (PLS-SVM) to 9.38%. Five-week average has been raised from 13.02% (chaotic model), 15.69% (ANN), and 15.92% (PLS-SVM) to 11.27%. PMID:25301508

  9. Optimization of Cooling Unit Design for Automotive Exhaust-Based Thermoelectric Generators

    NASA Astrophysics Data System (ADS)

    Su, C. Q.; Xu, M.; Wang, W. S.; Deng, Y. D.; Liu, X.; Tang, Z. B.

    2015-06-01

    Integrating a thermoelectric cooler (TEC) into the engine cooling system has various advantages including reducing additional mechanical parts, and saving energy and space for automotive applications. Based on performance parameters of the engine and thermoelectric modules, three different TEC configurations called plate-shape, stripe-shape, and diamond-shape are constructed with development of simulations of the different TECs and the performance of the circulating coolant. Based on these simulations, the velocity, pressure, and temperature fields of the coolant are obtained for further research. Besides, the temperature of the TEC and the output power of the thermoelectric generator (TEG) are acquired experimentally. Comparing the working performance of the different TECs, the simulation and experimental results show that the TEG using the diamond-shaped TEC achieves a relatively ideal performance. Finally, some measures are proposed to improve the cooling system, providing guidelines for future research.

  10. Fundamental studies of the properties of photoresists based on resins containing polymer-bound photoacid generators

    NASA Astrophysics Data System (ADS)

    Lee, Cheng-Tsung; Jarnagin, Nathan D.; Wang, Mingxing; Gonsalves, Kenneth E.; Robert, Jeanette M.; Yueh, Wang; Henderson, Clifford L.

    2006-03-01

    Conventional chemically amplified photoresist formulations are complex mixtures that include a protected polymer resin and a small molecule photoacid generator (PAG). The limited compatibility of the PAG with resist resin and the mobility of the small molecule additive can lead to problems including PAG phase separation, non-uniform initial PAG and photoacid distribution, and acid migration during the post-exposure baking (PEB) processes. The incorporation of PAG units into the main chain of the polymer resin is one possible method to alleviate these problems. Recently, we have investigated methacrylate based resists which incorporate novel PAG functional groups into the polymer main chain. These materials have demonstrated good resolution performance for both 193 nm and EUV exposure for sub-100 nm patterning. However, limited information is available on the effect of binding the PAG to the polymer on PAG photoreactivity and photoacid diffusivity. In this work, the photoacid generation rate constant (commonly referred to as the Dill C parameter for the PAG) of both triflate polymer-bound PAG and blended PAG photoresists based on poly(γ-butyrolactone methacrylate -co-2-ethyl-2-adamantyl methacrylate ) resists were determined by a new technique utilizing both quantitative FTIR spectroscopy and kinetic model fitting. The results indicate that the polymer-bound PAG resist has a lower photoacid generation rate constant (C=0.0122) than the blend PAG one (C=0.2647). This large difference in Dill C parameters would indicate that the sensitivity of the polymer-bound PAG resist is substantially lower than that of the analogous blended sample which is consistent with contrast curve data for these two samples.

  11. AQUARIUS, the next generation mid-IR detector for ground-based astronomy

    NASA Astrophysics Data System (ADS)

    Ives, Derek; Finger, Gert; Jakob, Gerd; Eschbaumer, Siegfried; Mehrgan, Leander; Meyer, Manfred; Steigmeier, Joerg

    2012-07-01

    ESO has recently funded the development of the AQUARIUS detector at Raytheon Vision Systems, a new mega-pixel Si:As Impurity Band Conduction array for use in ground based astronomical applications at wavelengths between 3 - 28 μm. The array has been designed to have low noise, low dark current, switchable gain and be read out at very high frame rates. It has 64 individual outputs capable of pixel read rates of 3MHz, implying continuous data-rates in excess of 300 Mbytes/second. It is scheduled for deployment into the VISIR instrument at the VLT in 2012, for next generation VLTI instruments and base-lined for METIS, the mid-IR candidate instrument for the E-ELT. A new mid-IR test facility has been developed for AQUARIUS detector development which includes a low thermal background cryostat, high speed cryogenic pre-amplification and high speed data acquisition and detector operation at 5K. We report on all the major performance aspects of this new detector including conversion gain, read noise, dark generation rate, linearity, well capacity, pixel operability, low frequency noise, persistence and electrical cross-talk. We describe the many possible readout modes of this detector and their application. We also report on external issues with the operation of these detectors at such low temperatures. Finally we report on the electronic developments required to operate such a detector at the required high data rates and in a typical mid-IR instrument.

  12. Automatic Generation of High Quality DSM Based on IRS-P5 Cartosat-1 Stereo Data

    NASA Astrophysics Data System (ADS)

    d'Angelo, Pablo; Uttenthaler, Andreas; Carl, Sebastian; Barner, Frithjof; Reinartz, Peter

    2010-12-01

    IRS-P5 Cartosat-1 high resolution stereo satellite imagery is well suited for the creation of digital surface models (DSM). A system for highly automated and operational DSM and orthoimage generation based on IRS-P5 Cartosat-1 imagery is presented, with an emphasis on automated processing and product quality. The proposed system processes IRS-P5 level-1 stereo scenes using the rational polynomial coefficients (RPC) universal sensor model. The described method uses an RPC correction based on DSM alignment instead of using reference images with a lower lateral accuracy, this results in improved geolocation of the DSMs and orthoimages. Following RPC correction, highly detailed DSMs with 5 m grid spacing are derived using Semiglobal Matching. The proposed method is part of an operational Cartosat-1 processor for the generation of a high resolution DSM. Evaluation of 18 scenes against independent ground truth measurements indicates a mean lateral error (CE90) of 6.7 meters and a mean vertical accuracy (LE90) of 5.1 meters.

  13. Incrementally learning objects by touch: online discriminative and generative models for tactile-based recognition.

    PubMed

    Soh, Harold; Demiris, Yiannis

    2014-01-01

    Human beings not only possess the remarkable ability to distinguish objects through tactile feedback but are further able to improve upon recognition competence through experience. In this work, we explore tactile-based object recognition with learners capable of incremental learning. Using the sparse online infinite Echo-State Gaussian process (OIESGP), we propose and compare two novel discriminative and generative tactile learners that produce probability distributions over objects during object grasping/palpation. To enable iterative improvement, our online methods incorporate training samples as they become available. We also describe incremental unsupervised learning mechanisms, based on novelty scores and extreme value theory, when teacher labels are not available. We present experimental results for both supervised and unsupervised learning tasks using the iCub humanoid, with tactile sensors on its five-fingered anthropomorphic hand, and 10 different object classes. Our classifiers perform comparably to state-of-the-art methods (C4.5 and SVM classifiers) and findings indicate that tactile signals are highly relevant for making accurate object classifications. We also show that accurate "early" classifications are possible using only 20-30 percent of the grasp sequence. For unsupervised learning, our methods generate high quality clusterings relative to the widely-used sequential k-means and self-organising map (SOM), and we present analyses into the differences between the approaches. PMID:25532151

  14. MuffinInfo: HTML5-Based Statistics Extractor from Next-Generation Sequencing Data.

    PubMed

    Alic, Andy S; Blanquer, Ignacio

    2016-09-01

    Usually, the information known a priori about a newly sequenced organism is limited. Even resequencing the same organism can generate unpredictable output. We introduce MuffinInfo, a FastQ/Fasta/SAM information extractor implemented in HTML5 capable of offering insights into next-generation sequencing (NGS) data. Our new tool can run on any software or hardware environment, in command line or graphically, and in browser or standalone. It presents information such as average length, base distribution, quality scores distribution, k-mer histogram, and homopolymers analysis. MuffinInfo improves upon the existing extractors by adding the ability to save and then reload the results obtained after a run as a navigable file (also supporting saving pictures of the charts), by supporting custom statistics implemented by the user, and by offering user-adjustable parameters involved in the processing, all in one software. At the moment, the extractor works with all base space technologies such as Illumina, Roche, Ion Torrent, Pacific Biosciences, and Oxford Nanopore. Owing to HTML5, our software demonstrates the readiness of web technologies for mild intensive tasks encountered in bioinformatics. PMID:27606794

  15. Adapting a GIS-Based Multicriteria Decision Analysis Approach for Evaluating New Power Generating Sites

    SciTech Connect

    Omitaomu, Olufemi A; Blevins, Brandon R; Jochem, Warren C; Mays, Gary T; Belles, Randy; Hadley, Stanton W; Harrison, Thomas J; Bhaduri, Budhendra L; Neish, Bradley S; Rose, Amy N

    2012-01-01

    There is a growing need to site new power generating plants that use cleaner energy sources due to increased regulations on air and water pollution and a sociopolitical desire to develop more clean energy sources. To assist utility and energy companies as well as policy-makers in evaluating potential areas for siting new plants in the contiguous United States, a geographic information system (GIS)-based multicriteria decision analysis approach is presented in this paper. The presented approach has led to the development of the Oak Ridge Siting Analysis for power Generation Expansion (OR-SAGE) tool. The tool takes inputs such as population growth, water availability, environmental indicators, and tectonic and geological hazards to provide an in-depth analysis for siting options. To the utility and energy companies, the tool can quickly and effectively provide feedback on land suitability based on technology specific inputs. However, the tool does not replace the required detailed evaluation of candidate sites. To the policy-makers, the tool provides the ability to analyze the impacts of future energy technology while balancing competing resource use.

  16. The design and construction of a pulsed beam generation system based on high intensity cyclotron

    NASA Astrophysics Data System (ADS)

    An, ShiZhong; Yin, ZhiGuo; Li, PengZhan; Song, GuoFang; Wu, LongCheng; Guan, FengPing; Xie, HuaiDong; Jia, XianLu; Lu, YinLong; Zhang, TianJue

    2011-12-01

    In order to perform the studies on a pulsed beam generation system based on a high intensity cyclotron, a test beam line with a pulsed beam generation for a 10 MeV compact cyclotron (CYCIAE-10) has been designed and constructed at China Institute of Atomic Energy (CIAE). A 70 MHz continuous H-beam can be pulsed to the pulse length of less than 10 ns with a repetition rate of 4.4 MHz. The sine waveform with a frequency of 2.2 MHz is adopted for the chopper and a mesh structure with single drift and dual gaps is used for the 70 MHz buncher. A helical resonator is designed and constructed based on simulations and experiments on the RF matching for the chopper. A helical inductance loop that is exceptionally large of its kind and equipped with water cooling for the resonator has been successfully wound and a 500 W solid RF amplifier has been manufactured. A special measuring device has been designed, which can be used to measure both the DC beam and the pulsed beam. The required pulsed beam was obtained after pulsed beam tuning.

  17. Implementation of Cloud based Next Generation Sequencing data analysis in a clinical laboratory

    PubMed Central

    2014-01-01

    Background The introduction of next generation sequencing (NGS) has revolutionized molecular diagnostics, though several challenges remain limiting the widespread adoption of NGS testing into clinical practice. One such difficulty includes the development of a robust bioinformatics pipeline that can handle the volume of data generated by high-throughput sequencing in a cost-effective manner. Analysis of sequencing data typically requires a substantial level of computing power that is often cost-prohibitive to most clinical diagnostics laboratories. Findings To address this challenge, our institution has developed a Galaxy-based data analysis pipeline which relies on a web-based, cloud-computing infrastructure to process NGS data and identify genetic variants. It provides additional flexibility, needed to control storage costs, resulting in a pipeline that is cost-effective on a per-sample basis. It does not require the usage of EBS disk to run a sample. Conclusions We demonstrate the validation and feasibility of implementing this bioinformatics pipeline in a molecular diagnostics laboratory. Four samples were analyzed in duplicate pairs and showed 100% concordance in mutations identified. This pipeline is currently being used in the clinic and all identified pathogenic variants confirmed using Sanger sequencing further validating the software. PMID:24885806

  18. Broadband wavelength converters with flattop responses based on cascaded second-harmonic generation and difference frequency generation in Bessel-chirped gratings.

    PubMed

    Liu, Tao; Djordjevic, Ivan B; Song, Zekun; Chen, Ying; Zhang, Rongxiang; Zhang, Ke; Zhao, Wei; Li, Baogang

    2016-05-16

    We investigate ultra-broadband wavelength converters based on cascaded second-harmonic generation and difference frequency generation using Bessel-chirped gratings (BCGs) in lithium niobate waveguides, and compare them to the ones using uniform grating and segmented grating, respectively. For the same length and power, the BCGs show broader bandwidth than the other two types of grating. The ripple of the matching response is very small as well. Analysis also shows that almost the same conversion bandwidth and maximum conversion efficiency with tolerant response flatness can be achieved when the manufacturing tolerance of the waveguide length is smaller than 0.1 cm. PMID:27409916

  19. Brief Communication: Contrast-stretching- and histogram-smoothness-based synthetic aperture radar image enhancement for flood map generation

    NASA Astrophysics Data System (ADS)

    Nazir, F.; Riaz, M. M.; Ghafoor, A.; Arif, F.

    2015-02-01

    Synthetic-aperture-radar-image-based flood map generation is usually a challenging task (due to degraded contrast). A three-step approach (based on adaptive histogram clipping, histogram remapping and smoothing) is proposed for generation of a more visualized flood map image. The pre- and post-flood images are adaptively histogram equalized. The hidden details in difference image are enhanced using contrast-based enhancement and histogram smoothing. A fast-ready flood map is then generated using equalized pre-, post- and difference images. Results (evaluated using different data sets) show significance of the proposed technique.

  20. Knowledge-based optical system design: some optical systems generated by the KBOSD

    NASA Astrophysics Data System (ADS)

    Nouri, Taoufik; Erard, Pierre-Jean

    1993-04-01

    This work is a new approach for the design of start optical systems and represents a new contribution of artificial intelligence techniques in the optical design field. A knowledge-based optical-systems design (KBOSD), based on artificial intelligence algorithms, first order logic, knowledge representation, rules, and heuristics on lens design, is realized. This KBOSD is equipped with optical knowledge in the domain of centered dioptrical optical systems used at low aperture and small field angles. This KBOSD generates centered dioptrical, on-axis and low-aperture optical-systems, which are used as start systems for the subsequent optimization by existing lens design programs. This KBOSD produces monochromatic or polychromatic optical systems, such as singlet lens, doublet lens, triplet lens, reversed singlet lens, reversed doublet lens, reversed triplet lens, and telescopes. In the design of optical systems, the KBOSD takes into account many user constraints such as cost, resistance of the optical material (glass) to chemical, thermal, and mechanical effects, as well as the optical quality such as minimal aberrations and chromatic aberrations corrections. This KBOSD is developed in the programming language Prolog and has knowledge on optical design principles and optical properties and uses neither a lens library nor a lens data base, it is completely based on optical design knowledge.

  1. Self-powered electrospinning apparatus based on a hand-operated Wimshurst generator

    NASA Astrophysics Data System (ADS)

    Han, Wen-Peng; Huang, Yuan-Yuan; Yu, Miao; Zhang, Jun-Cheng; Yan, Xu; Yu, Gui-Feng; Zhang, Hong-Di; Yan, Shi-Ying; Long, Yun-Ze

    2015-03-01

    A conventional electrospinning setup cannot work without a plug (electricity supply). In this article, we report a self-powered electrospinning setup based on a hand-operated Wimshurst generator. The new device has better applicability and portability than a typical conventional electrospinning setup because it is lightweight and can work without an external power supply. Experimental parameters of the apparatus such as the minimum number of handle turns to generate enough energy to spin, rotation speed of the handle and electrospinning distance were investigated. Different polymers such as polystyrene (PS), poly(vinylidene fluoride) (PVDF), polycaprolactone (PCL) and polylactic acid (PLA) were electrospun into ultrathin fibers successfully by this apparatus. The stability, reliability, and repeatability of the new apparatus demonstrate that it can be used as not only a demonstrator for an electrospinning process, but also a beneficial complement to conventional electrospinning especially where or when without a power supply, and may be used in wound healing and rapid hemostasis, etc.A conventional electrospinning setup cannot work without a plug (electricity supply). In this article, we report a self-powered electrospinning setup based on a hand-operated Wimshurst generator. The new device has better applicability and portability than a typical conventional electrospinning setup because it is lightweight and can work without an external power supply. Experimental parameters of the apparatus such as the minimum number of handle turns to generate enough energy to spin, rotation speed of the handle and electrospinning distance were investigated. Different polymers such as polystyrene (PS), poly(vinylidene fluoride) (PVDF), polycaprolactone (PCL) and polylactic acid (PLA) were electrospun into ultrathin fibers successfully by this apparatus. The stability, reliability, and repeatability of the new apparatus demonstrate that it can be used as not only a demonstrator

  2. A D-D/D-T fusion reaction based neutron generator system for liver tumor BNCT

    SciTech Connect

    Koivunoro, H.; Lou, T.P.; Leung, K. N.; Reijonen, J.

    2003-04-02

    Boron-neutron capture therapy (BNCT) is an experimental radiation treatment modality used for highly malignant tumor treatments. Prior to irradiation with low energetic neutrons, a 10B compound is located selectively in the tumor cells. The effect of the treatment is based on the high LET radiation released in the {sup 10}B(n,{alpha}){sup 7}Li reaction with thermal neutrons. BNCT has been used experimentally for brain tumor and melanoma treatments. Lately applications of other severe tumor type treatments have been introduced. Results have shown that liver tumors can also be treated by BNCT. At Lawrence Berkeley National Laboratory, various compact neutron generators based on D-D or D-T fusion reactions are being developed. The earlier theoretical studies of the D-D or D-T fusion reaction based neutron generators have shown that the optimal moderator and reflector configuration for brain tumor BNCT can be created. In this work, the applicability of 2.5 MeV neutrons for liver tumor BNCT application was studied. The optimal neutron energy for external liver treatments is not known. Neutron beams of different energies (1eV < E < 100 keV) were simulated and the dose distribution in the liver was calculated with the MCNP simulation code. In order to obtain the optimal neutron energy spectrum with the D-D neutrons, various moderator designs were performed using MCNP simulations. In this article the neutron spectrum and the optimized beam shaping assembly for liver tumor treatments is presented.

  3. Performing Label-Fusion-Based Segmentation Using Multiple Automatically Generated Templates

    PubMed Central

    Chakravarty, M. Mallar; Steadman, Patrick; van Eede, Matthijs C.; Calcott, Rebecca D.; Gu, Victoria; Shaw, Philip; Raznahan, Armin; Collins, D. Louis; Lerch, Jason P.

    2016-01-01

    Classically, model-based segmentation procedures match magnetic resonance imaging (MRI) volumes to an expertly labeled atlas using nonlinear registration. The accuracy of these techniques are limited due to atlas biases, misregistration, and resampling error. Multi-atlas-based approaches are used as a remedy and involve matching each subject to a number of manually labeled templates. This approach yields numerous independent segmentations that are fused using a voxel-by-voxel label-voting procedure. In this article, we demonstrate how the multi-atlas approach can be extended to work with input atlases that are unique and extremely time consuming to construct by generating a library of multiple automatically generated templates of different brains (MAGeT Brain). We demonstrate the efficacy of our method for the mouse and human using two different nonlinear registration algorithms (ANIMAL and ANTs). The input atlases consist a high-resolution mouse brain atlas and an atlas of the human basal ganglia and thalamus derived from serial histological data. MAGeT Brain segmentation improves the identification of the mouse anterior commissure (mean Dice Kappa values (κ = 0.801), but may be encountering a ceiling effect for hippocampal segmentations. Applying MAGeT Brain to human subcortical structures improves segmentation accuracy for all structures compared to regular model-based techniques (κ = 0.845, 0.752, and 0.861 for the striatum, globus pallidus, and thalamus, respectively). Experiments performed with three manually derived input templates suggest that MAGeT Brain can approach or exceed the accuracy of multi-atlas label-fusion segmentation (κ = 0.894, 0.815, and 0.895 for the striatum, globus pallidus, and thalamus, respectively). PMID:22611030

  4. Performing label-fusion-based segmentation using multiple automatically generated templates.

    PubMed

    Chakravarty, M Mallar; Steadman, Patrick; van Eede, Matthijs C; Calcott, Rebecca D; Gu, Victoria; Shaw, Philip; Raznahan, Armin; Collins, D Louis; Lerch, Jason P

    2013-10-01

    Classically, model-based segmentation procedures match magnetic resonance imaging (MRI) volumes to an expertly labeled atlas using nonlinear registration. The accuracy of these techniques are limited due to atlas biases, misregistration, and resampling error. Multi-atlas-based approaches are used as a remedy and involve matching each subject to a number of manually labeled templates. This approach yields numerous independent segmentations that are fused using a voxel-by-voxel label-voting procedure. In this article, we demonstrate how the multi-atlas approach can be extended to work with input atlases that are unique and extremely time consuming to construct by generating a library of multiple automatically generated templates of different brains (MAGeT Brain). We demonstrate the efficacy of our method for the mouse and human using two different nonlinear registration algorithms (ANIMAL and ANTs). The input atlases consist a high-resolution mouse brain atlas and an atlas of the human basal ganglia and thalamus derived from serial histological data. MAGeT Brain segmentation improves the identification of the mouse anterior commissure (mean Dice Kappa values (κ = 0.801), but may be encountering a ceiling effect for hippocampal segmentations. Applying MAGeT Brain to human subcortical structures improves segmentation accuracy for all structures compared to regular model-based techniques (κ = 0.845, 0.752, and 0.861 for the striatum, globus pallidus, and thalamus, respectively). Experiments performed with three manually derived input templates suggest that MAGeT Brain can approach or exceed the accuracy of multi-atlas label-fusion segmentation (κ = 0.894, 0.815, and 0.895 for the striatum, globus pallidus, and thalamus, respectively). PMID:22611030

  5. Optimal battery sizing in photovoltaic based distributed generation using enhanced opposition-based firefly algorithm for voltage rise mitigation.

    PubMed

    Wong, Ling Ai; Shareef, Hussain; Mohamed, Azah; Ibrahim, Ahmad Asrul

    2014-01-01

    This paper presents the application of enhanced opposition-based firefly algorithm in obtaining the optimal battery energy storage systems (BESS) sizing in photovoltaic generation integrated radial distribution network in order to mitigate the voltage rise problem. Initially, the performance of the original firefly algorithm is enhanced by utilizing the opposition-based learning and introducing inertia weight. After evaluating the performance of the enhanced opposition-based firefly algorithm (EOFA) with fifteen benchmark functions, it is then adopted to determine the optimal size for BESS. Two optimization processes are conducted where the first optimization aims to obtain the optimal battery output power on hourly basis and the second optimization aims to obtain the optimal BESS capacity by considering the state of charge constraint of BESS. The effectiveness of the proposed method is validated by applying the algorithm to the 69-bus distribution system and by comparing the performance of EOFA with conventional firefly algorithm and gravitational search algorithm. Results show that EOFA has the best performance comparatively in terms of mitigating the voltage rise problem. PMID:25054184

  6. Optimal Battery Sizing in Photovoltaic Based Distributed Generation Using Enhanced Opposition-Based Firefly Algorithm for Voltage Rise Mitigation

    PubMed Central

    Wong, Ling Ai; Shareef, Hussain; Mohamed, Azah; Ibrahim, Ahmad Asrul

    2014-01-01

    This paper presents the application of enhanced opposition-based firefly algorithm in obtaining the optimal battery energy storage systems (BESS) sizing in photovoltaic generation integrated radial distribution network in order to mitigate the voltage rise problem. Initially, the performance of the original firefly algorithm is enhanced by utilizing the opposition-based learning and introducing inertia weight. After evaluating the performance of the enhanced opposition-based firefly algorithm (EOFA) with fifteen benchmark functions, it is then adopted to determine the optimal size for BESS. Two optimization processes are conducted where the first optimization aims to obtain the optimal battery output power on hourly basis and the second optimization aims to obtain the optimal BESS capacity by considering the state of charge constraint of BESS. The effectiveness of the proposed method is validated by applying the algorithm to the 69-bus distribution system and by comparing the performance of EOFA with conventional firefly algorithm and gravitational search algorithm. Results show that EOFA has the best performance comparatively in terms of mitigating the voltage rise problem. PMID:25054184

  7. 75 FR 70741 - TPF Generation Holdings, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-18

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission TPF Generation Holdings, LLC; Supplemental Notice That Initial Market-Based... supplemental notice in the above-referenced proceeding TPF Generation Holdings, LLC's application for...

  8. A new method to extract stable feature points based on self-generated simulation images

    NASA Astrophysics Data System (ADS)

    Long, Fei; Zhou, Bin; Ming, Delie; Tian, Jinwen

    2015-10-01

    Recently, image processing has got a lot of attention in the field of photogrammetry, medical image processing, etc. Matching two or more images of the same scene taken at different times, by different cameras, or from different viewpoints, is a popular and important problem. Feature extraction plays an important part in image matching. Traditional SIFT detectors reject the unstable points by eliminating the low contrast and edge response points. The disadvantage is the need to set the threshold manually. The main idea of this paper is to get the stable extremums by machine learning algorithm. Firstly we use ASIFT approach coupled with the light changes and blur to generate multi-view simulated images, which make up the set of the simulated images of the original image. According to the way of generating simulated images set, affine transformation of each generated image is also known. Instead of the traditional matching process which contain the unstable RANSAC method to get the affine transformation, this approach is more stable and accurate. Secondly we calculate the stability value of the feature points by the set of image with its affine transformation. Then we get the different feature properties of the feature point, such as DOG features, scales, edge point density, etc. Those two form the training set while stability value is the dependent variable and feature property is the independent variable. At last, a process of training by Rank-SVM is taken. We will get a weight vector. In use, based on the feature properties of each points and weight vector calculated by training, we get the sort value of each feature point which refers to the stability value, then we sort the feature points. In conclusion, we applied our algorithm and the original SIFT detectors to test as a comparison. While in different view changes, blurs, illuminations, it comes as no surprise that experimental results show that our algorithm is more efficient.

  9. Diffractive optics in large sizes: computer-generated holograms (CGH) based on Bayfol HX photopolymer

    NASA Astrophysics Data System (ADS)

    Bruder, Friedrich-Karl; Fäcke, Thomas; Hagen, Rainer; Hönel, Dennis; Kleinschmidt, Tim Patrick; Orselli, Enrico; Rewitz, Christian; Rölle, Thomas; Walze, Günther

    2015-03-01

    Volume Holographic Optical Elements (vHOE) offer angular and spectral Bragg selectivity that can be tuned by film thickness and holographic recording conditions. With the option to integrate complex optical function in a very thin plastic layer formerly heavy refractive optics can be made thin and lightweight especially for large area applications like liquid crystal displays, projection screens or photovoltaic. Additionally their Bragg selectivity enables the integration of several completely separated optical functions in the same film. The new instant developing photopolymer film (Bayfol® HX) paves the way towards new cost effective diffractive large optics, due to its easy holographic recording and environmental stability. A major bottleneck for large area applications has been the master hologram recording which traditionally needs expensive, large high precision optical equipment and high power laser with long coherence length. Further the recording setup needs to be rearranged for a change in optical design. In this paper we describe an alternative method for large area holographic master recording, using standard optics and low power lasers in combination with an x, y-translation stage. In this setup small sub-holograms generated by a phase only spatial light modulator (SLM) are recorded next to each other to generate a large size vHOE. The setup is flexible to generate various types of HOEs without the need of a change in the mechanical and optical construction by convenient SLM programming. One Application example and parameter studies for printed vHOEs based on Bayfol® HX Photopolymer will be given.

  10. Process-oriented Simulation of Runoff Generation on Arable Fields Using a Physically Based Hydrological Model

    NASA Astrophysics Data System (ADS)

    Winter, F.; Disse, M.

    2011-12-01

    In Germany, aside from technical flood protection and forecasting, modern flood protection strategies include distributed flood control measures. On arable fields these measures comprise of increasing infiltration ability due to different tillage practices such as conservational tillage or no-tillage. Tillage practices have a significant effect on the runoff generation process. Bare soils are prone to forming soil crusts during extreme rainfall events especially on Loessial soils that are abundant in Central European landscapes, and soil crusts promote surface runoff and erosion. Due to the impact of raindrops, the topsoil aggregates are broken and form a layer of a few millimeters to centimeters with very low hydraulic conductivity. One way to describe this process is by using a modified Horton infiltration equation. WaSiM-ETH is a physically based hydrological modeling system developed by SCHULLA (1997) to analyze the spatial and temporal distributed flow processes in complex catchments. In order to investigate the effect of soil crusts on runoff generation on arable fields, WaSiM-ETH was extended by adding a silting module which is able to simulate the process of soil crust formation. It has been shown that sprinkler experiments could be simulated more efficiently with the model extension than with the simulation of runoff generation according to the Mualem-van-Genuchten parameterization. This effect is extended to a lower mesoscale agricultural catchment for a number of different high intensity storm events. Finally, scenario setups show the potential of surface water retention for different tillage practices. Literature: SCHULLA, J. (1997): Hydrologische Modellierung von Flussgebieten zur Abschätzung der Folgen von Klimaänderungen, Dissertation, ETH Zürich, 161. S. (in German) http://www.unibw.de/ifw/WWR-en/forschung-en/einflussbewirtschaftung-en?set_language=en

  11. a Hadoop-Based Algorithm of Generating dem Grid from Point Cloud Data

    NASA Astrophysics Data System (ADS)

    Jian, X.; Xiao, X.; Chengfang, H.; Zhizhong, Z.; Zhaohui, W.; Dengzhong, Z.

    2015-04-01

    Airborne LiDAR technology has proven to be the most powerful tools to obtain high-density, high-accuracy and significantly detailed surface information of terrain and surface objects within a short time, and from which the Digital Elevation Model of high quality can be extracted. Point cloud data generated from the pre-processed data should be classified by segmentation algorithms, so as to differ the terrain points from disorganized points, then followed by a procedure of interpolating the selected points to turn points into DEM data. The whole procedure takes a long time and huge computing resource due to high-density, that is concentrated on by a number of researches. Hadoop is a distributed system infrastructure developed by the Apache Foundation, which contains a highly fault-tolerant distributed file system (HDFS) with high transmission rate and a parallel programming model (Map/Reduce). Such a framework is appropriate for DEM generation algorithms to improve efficiency. Point cloud data of Dongting Lake acquired by Riegl LMS-Q680i laser scanner was utilized as the original data to generate DEM by a Hadoop-based algorithms implemented in Linux, then followed by another traditional procedure programmed by C++ as the comparative experiment. Then the algorithm's efficiency, coding complexity, and performance-cost ratio were discussed for the comparison. The results demonstrate that the algorithm's speed depends on size of point set and density of DEM grid, and the non-Hadoop implementation can achieve a high performance when memory is big enough, but the multiple Hadoop implementation can achieve a higher performance-cost ratio, while point set is of vast quantities on the other hand.

  12. A collision-based model for measuring bedload transport from the seismic waves generated by rivers

    NASA Astrophysics Data System (ADS)

    Roth, D. L.; Finnegan, N. J.; Brodsky, E. E.; Stark, C. P.

    2011-12-01

    Accurately predicting rates of coarse sediment transport in river channels is a central goal of fluvial geomorphology and civil engineering. However, it is difficult to evaluate sediment transport and bedrock abrasion models in large rivers because quantitative measures of bedload transport are labor intensive and often dangerous to obtain in floods. Two recent studies show that the amplitude of seismic waves near rivers may record bedload flux, indicating that seismometers near rivers provide a potential means of monitoring bedload transport. In an effort to better interpret seismic waves generated by rivers, we seek a relationship between the variables governing bedload transport and seismic waves. Our approach relies on the fact that elastic waves are generated when momentum is transferred to the bed during a bedload particle impact. For an impacting particle of known mass and velocity, the momentum transfer can be computed from Hertzian impact theory. Here we combine analytic results based on Hertzian and elastic wave theories with empirical equations developed to describe the ballistics of bedload particles in terms of fluid shear stress and grain size. From this synthesis we arrive at a semi-analytic expression that predicts how the characteristic frequencies and amplitudes of seismic waves generated from saltating bedload particles should scale with fluid shear stress, grain size, and coarse sediment flux. Preliminary tests of our predictions using previously published and newly acquired laboratory data indicate that seismic signals near rivers can record information about the size, velocity and number of particles impacting the bed. Additionally, our analytical results help identify bedload transport events in seismic data collected along the Chijiawan River in Taiwan. Here the river is evolving rapidly in response to a dam removal - resulting in predictable changes in bedload transport efficiency in time and space that we can compare to local seismic data.

  13. Strain Selection for Generation of O-Antigen-Based Glycoconjugate Vaccines against Invasive Nontyphoidal Salmonella Disease

    PubMed Central

    Saul, Allan; MacLennan, Calman A.; Micoli, Francesca; Rondini, Simona

    2015-01-01

    Nontyphoidal Salmonellae, principally S. Typhimurium and S. Enteritidis, are a major cause of invasive bloodstream infections in sub-Saharan Africa with no vaccine currently available. Conjugation of lipopolysaccharide O-antigen to a carrier protein constitutes a promising vaccination strategy. Here we describe a rational process to select the most appropriate isolates of Salmonella as source of O-antigen for developing a bivalent glycoconjugate vaccine. We screened a library of 30 S. Typhimurium and 21 S. Enteritidis in order to identify the most suitable strains for large scale O-antigen production and generation of conjugate vaccines. Initial screening was based on growth characteristics, safety profile of the isolates, O-antigen production, and O-antigen characteristics in terms of molecular size, O-acetylation and glucosylation level and position, as determined by phenol sulfuric assay, NMR, HPLC-SEC and HPAEC-PAD. Three animal isolates for each serovar were identified and used to synthesize candidate glycoconjugate vaccines, using CRM197 as carrier protein. The immunogenicity of these conjugates and the functional activity of the induced antibodies was investigated by ELISA, serum bactericidal assay and flow cytometry. S. Typhimurium O-antigen showed high structural diversity, including O-acetylation of rhamnose in a Malawian invasive strain generating a specific immunodominant epitope. S. Typhimurium conjugates provoked an anti-O-antigen response primarily against the O:5 determinant. O-antigen from S. Enteritidis was structurally more homogeneous than from S. Typhimurium, and no idiosyncratic antibody responses were detected for the S. Enteritidis conjugates. Of the three initially selected isolates, two S. Typhimurium (1418 and 2189) and two S. Enteritidis (502 and 618) strains generated glycoconjugates able to induce high specific antibody levels with high breadth of serovar-specific strain coverage, and were selected for use in vaccine production. The

  14. Strain Selection for Generation of O-Antigen-Based Glycoconjugate Vaccines against Invasive Nontyphoidal Salmonella Disease.

    PubMed

    Lanzilao, Luisa; Stefanetti, Giuseppe; Saul, Allan; MacLennan, Calman A; Micoli, Francesca; Rondini, Simona

    2015-01-01

    Nontyphoidal Salmonellae, principally S. Typhimurium and S. Enteritidis, are a major cause of invasive bloodstream infections in sub-Saharan Africa with no vaccine currently available. Conjugation of lipopolysaccharide O-antigen to a carrier protein constitutes a promising vaccination strategy. Here we describe a rational process to select the most appropriate isolates of Salmonella as source of O-antigen for developing a bivalent glycoconjugate vaccine. We screened a library of 30 S. Typhimurium and 21 S. Enteritidis in order to identify the most suitable strains for large scale O-antigen production and generation of conjugate vaccines. Initial screening was based on growth characteristics, safety profile of the isolates, O-antigen production, and O-antigen characteristics in terms of molecular size, O-acetylation and glucosylation level and position, as determined by phenol sulfuric assay, NMR, HPLC-SEC and HPAEC-PAD. Three animal isolates for each serovar were identified and used to synthesize candidate glycoconjugate vaccines, using CRM197 as carrier protein. The immunogenicity of these conjugates and the functional activity of the induced antibodies was investigated by ELISA, serum bactericidal assay and flow cytometry. S. Typhimurium O-antigen showed high structural diversity, including O-acetylation of rhamnose in a Malawian invasive strain generating a specific immunodominant epitope. S. Typhimurium conjugates provoked an anti-O-antigen response primarily against the O:5 determinant. O-antigen from S. Enteritidis was structurally more homogeneous than from S. Typhimurium, and no idiosyncratic antibody responses were detected for the S. Enteritidis conjugates. Of the three initially selected isolates, two S. Typhimurium (1418 and 2189) and two S. Enteritidis (502 and 618) strains generated glycoconjugates able to induce high specific antibody levels with high breadth of serovar-specific strain coverage, and were selected for use in vaccine production. The

  15. Physics-Based 3-D Simulation for Earthquake Generation Cycles at Plate Interfaces in Subduction Zones

    NASA Astrophysics Data System (ADS)

    Hashimoto, Chihiro; Fukuyama, Eiichi; Matsu'ura, Mitsuhiro

    2014-08-01

    The generation of interplate earthquakes can be regarded as a process of tectonic stress accumulation and release, driven by relative plate motion. We completed a physics-based simulation system for earthquake generation cycles at plate interfaces in the Japan region, where the Pacific plate is descending beneath the North American and Philippine Sea plates, and the Philippine Sea plate is descending beneath the North American and Eurasian plates. The system is composed of a quasi-static tectonic loading model and a dynamic rupture propagation model, developed on a realistic 3-D plate interface model. The driving force of the system is relative plate motion. In the quasi-static tectonic loading model, mechanical interaction at plate interfaces is rationally represented by the increase of tangential displacement discontinuity (fault slip) across them on the basis of dislocation theory for an elastic surface layer overlying Maxwell-type viscoelastic half-space. In the dynamic rupture propagation model, stress changes due to fault slip motion on non-planar plate interfaces are evaluated with the boundary integral equation method. The progress of seismic (dynamic) or aseismic (quasi-static) fault slip on plate interfaces is governed by a slip- and time-dependent fault constitutive law. As an example, we numerically simulated earthquake generation cycles at the source region of the 1968 Tokachi-oki earthquake on the North American-Pacific plate interface. From the numerical simulation, we can see that postseismic stress relaxation in the asthenosphere accelerates stress accumulation in the source region. When the stress state of the source region is close to a critical level, dynamic rupture is rapidly accelerated and develops over the whole source region. When the stress state is much lower than the critical level, the rupture is not accelerated. This means that the stress state realized by interseismic tectonic loading essentially controls the subsequent dynamic

  16. Network Capacity Assessment of CHP-based Distributed Generation on Urban Energy Distribution Networks

    NASA Astrophysics Data System (ADS)

    Zhang, Xianjun

    The combined heat and power (CHP)-based distributed generation (DG) or dis-tributed energy resources (DERs) are mature options available in the present energy market, considered to be an effective solution to promote energy efficiency. In the urban environment, the electricity, water and natural gas distribution networks are becoming increasingly interconnected with the growing penetration of the CHP-based DG. Subsequently, this emerging interdependence leads to new topics meriting serious consideration: how much of the CHP-based DG can be accommodated and where to locate these DERs, and given preexisting constraints, how to quantify the mutual impacts on operation performances between these urban energy distribution networks and the CHP-based DG. The early research work was conducted to investigate the feasibility and design methods for one residential microgrid system based on existing electricity, water and gas infrastructures of a residential community, mainly focusing on the economic planning. However, this proposed design method cannot determine the optimal DG sizing and siting for a larger test bed with the given information of energy infrastructures. In this context, a more systematic as well as generalized approach should be developed to solve these problems. In the later study, the model architecture that integrates urban electricity, water and gas distribution networks, and the CHP-based DG system was developed. The proposed approach addressed the challenge of identifying the optimal sizing and siting of the CHP-based DG on these urban energy networks and the mutual impacts on operation performances were also quantified. For this study, the overall objective is to maximize the electrical output and recovered thermal output of the CHP-based DG units. The electricity, gas, and water system models were developed individually and coupled by the developed CHP-based DG system model. The resultant integrated system model is used to constrain the DG's electrical

  17. TALEN-based generation of a cynomolgus monkey disease model for human microcephaly.

    PubMed

    Ke, Qiong; Li, Weiqiang; Lai, Xingqiang; Chen, Hong; Huang, Lihua; Kang, Zhuang; Li, Kai; Ren, Jie; Lin, Xiaofeng; Zheng, Haiqing; Huang, Weijun; Ma, Yunhan; Xu, Dongdong; Chen, Zheng; Song, Xinming; Lin, Xinyi; Zhuang, Min; Wang, Tao; Zhuang, Fengfeng; Xi, Jianzhong; Mao, Frank Fuxiang; Xia, Huimin; Lahn, Bruce T; Zhou, Qi; Yang, Shihua; Xiang, Andy Peng

    2016-09-01

    Gene editing in non-human primates may lead to valuable models for exploring the etiologies and therapeutic strategies of genetically based neurological disorders in humans. However, a monkey model of neurological disorders that closely mimics pathological and behavioral deficits in humans has not yet been successfully generated. Microcephalin 1 (MCPH1) is implicated in the evolution of the human brain, and MCPH1 mutation causes microcephaly accompanied by mental retardation. Here we generated a cynomolgus monkey (Macaca fascicularis) carrying biallelic MCPH1 mutations using transcription activator-like effector nucleases. The monkey recapitulated most of the important clinical features observed in patients, including marked reductions in head circumference, premature chromosome condensation (PCC), hypoplasia of the corpus callosum and upper limb spasticity. Moreover, overexpression of MCPH1 in mutated dermal fibroblasts rescued the PCC syndrome. This monkey model may help us elucidate the role of MCPH1 in the pathogenesis of human microcephaly and better understand the function of this protein in the evolution of primate brain size. PMID:27502025

  18. MSEBAG: a dynamic classifier ensemble generation based on `minimum-sufficient ensemble' and bagging

    NASA Astrophysics Data System (ADS)

    Chen, Lei; Kamel, Mohamed S.

    2016-01-01

    In this paper, we propose a dynamic classifier system, MSEBAG, which is characterised by searching for the 'minimum-sufficient ensemble' and bagging at the ensemble level. It adopts an 'over-generation and selection' strategy and aims to achieve a good bias-variance trade-off. In the training phase, MSEBAG first searches for the 'minimum-sufficient ensemble', which maximises the in-sample fitness with the minimal number of base classifiers. Then, starting from the 'minimum-sufficient ensemble', a backward stepwise algorithm is employed to generate a collection of ensembles. The objective is to create a collection of ensembles with a descending fitness on the data, as well as a descending complexity in the structure. MSEBAG dynamically selects the ensembles from the collection for the decision aggregation. The extended adaptive aggregation (EAA) approach, a bagging-style algorithm performed at the ensemble level, is employed for this task. EAA searches for the competent ensembles using a score function, which takes into consideration both the in-sample fitness and the confidence of the statistical inference, and averages the decisions of the selected ensembles to label the test pattern. The experimental results show that the proposed MSEBAG outperforms the benchmarks on average.

  19. ActivitySim: large-scale agent based activity generation for infrastructure simulation

    SciTech Connect

    Gali, Emmanuel; Eidenbenz, Stephan; Mniszewski, Sue; Cuellar, Leticia; Teuscher, Christof

    2008-01-01

    The United States' Department of Homeland Security aims to model, simulate, and analyze critical infrastructure and their interdependencies across multiple sectors such as electric power, telecommunications, water distribution, transportation, etc. We introduce ActivitySim, an activity simulator for a population of millions of individual agents each characterized by a set of demographic attributes that is based on US census data. ActivitySim generates daily schedules for each agent that consists of a sequence of activities, such as sleeping, shopping, working etc., each being scheduled at a geographic location, such as businesses or private residences that is appropriate for the activity type and for the personal situation of the agent. ActivitySim has been developed as part of a larger effort to understand the interdependencies among national infrastructure networks and their demand profiles that emerge from the different activities of individuals in baseline scenarios as well as emergency scenarios, such as hurricane evacuations. We present the scalable software engineering principles underlying ActivitySim, the socia-technical modeling paradigms that drive the activity generation, and proof-of-principle results for a scenario in the Twin Cities, MN area of 2.6 M agents.

  20. Panel-Based Population Next-Generation Sequencing for Inherited Retinal Degenerations.

    PubMed

    Carrigan, Matthew; Duignan, Emma; Malone, Conor P G; Stephenson, Kirk; Saad, Tahira; McDermott, Ciara; Green, Andrew; Keegan, David; Humphries, Peter; Kenna, Paul F; Farrar, G Jane

    2016-01-01

    Inherited retinopathies affect approximately two and a half million people globally, yet the majority of affected patients lack clear genetic diagnoses given the diverse range of genes and mutations implicated in these conditions. We present results from a next-generation sequencing study of a large inherited retinal disease patient population, with the goal of providing clear and actionable genetic diagnoses. Targeted sequencing was performed on 539 individuals from 309 inherited retinal disease pedigrees. Causative mutations were identified in the majority (57%, 176/309) of pedigrees. We report the association of many previously unreported variants with retinal disease, as well as new disease phenotypes associated with known genes, including the first association of the SLC24A1 gene with retinitis pigmentosa. Population statistics reporting the genes most commonly implicated in retinal disease in the cohort are presented, as are some diagnostic conundrums that can arise during such studies. Inherited retinal diseases represent an exemplar group of disorders for the application of panel-based next-generation sequencing as an effective tool for detection of causative mutations. PMID:27624628

  1. Investigation of DC hybrid circuit breaker based on high-speed switch and arc generator.

    PubMed

    Wu, Yifei; Rong, Mingzhe; Wu, Yi; Yang, Fei; Li, Mei; Zhong, Jianying; Han, Guohui; Niu, Chunping; Hu, Yang

    2015-02-01

    A new design of DC hybrid circuit breaker based on high-speed switch (HSS) and arc generator (AG), which can drastically profit from low heat loss in normal state and fast current breaking under fault state, is presented and analyzed in this paper. AG is designed according to the magnetic pinch effect of liquid metal. By utilizing the arc voltage generated across AG, the fault current is rapidly commutated from HSS into parallel connected branch. As a consequence, the arcless open of HSS is achieved. The post-arc conducting resume time (Δ tc) of AG and the commutation original voltage (Uc), two key factors in the commutation process, are investigated experimentally. Particularly, influences of the liquid metal channel diameter (Φ) of AG, fault current rate of rise (di/dt) and Uc on Δ tc are focused on. Furthermore, a suitable Uc is determined during the current commutation process, aiming at the reliable arcless open of HSS and short breaking time. Finally, the fault current breaking test is carried out for the current peak value of 11.8 kA, and the validity of the design is confirmed by the experimental results. PMID:25725867

  2. Investigation of DC hybrid circuit breaker based on high-speed switch and arc generator

    NASA Astrophysics Data System (ADS)

    Wu, Yifei; Rong, Mingzhe; Wu, Yi; Yang, Fei; Li, Mei; Zhong, Jianying; Han, Guohui; Niu, Chunping; Hu, Yang

    2015-02-01

    A new design of DC hybrid circuit breaker based on high-speed switch (HSS) and arc generator (AG), which can drastically profit from low heat loss in normal state and fast current breaking under fault state, is presented and analyzed in this paper. AG is designed according to the magnetic pinch effect of liquid metal. By utilizing the arc voltage generated across AG, the fault current is rapidly commutated from HSS into parallel connected branch. As a consequence, the arcless open of HSS is achieved. The post-arc conducting resume time (Δ tc) of AG and the commutation original voltage (Uc), two key factors in the commutation process, are investigated experimentally. Particularly, influences of the liquid metal channel diameter (Φ) of AG, fault current rate of rise (di/dt) and Uc on Δ tc are focused on. Furthermore, a suitable Uc is determined during the current commutation process, aiming at the reliable arcless open of HSS and short breaking time. Finally, the fault current breaking test is carried out for the current peak value of 11.8 kA, and the validity of the design is confirmed by the experimental results.

  3. High flatness optical frequency comb generator based on the chirping of modulators

    NASA Astrophysics Data System (ADS)

    Qu, Kun; Zhao, Shanghong; Liang, Dan Ya; Zhu, Zihang; Dong, Chen; Li, Xuan

    2016-04-01

    A novel scheme for generation of an optical frequency comb (OFC) based on the chirping of two cascaded modulators is proposed. The first modulator is a dual-electrode Mach-Zehnder modulator (MZM), while the other modulator is an integrated MZM composed of two parallel MZMs that increases the number of comb lines. Our modified scheme can generate a large number of frequency lines with excellent flatness by simply modifying the chirp factor, and it is shown that up to 54 frequency lines could be observed. Theoretical analysis and simulation results show that under the variety of conditions that can be used in this scheme, the power fluctuations of the OFC lines are less than 0.5 dB in all cases; these results demonstrate the robustness of our scheme and verify its good accuracy and high stability with perfect flatness. Additionally, our modified scheme has the merit of tunable frequency spacing, which is practical for experimental realization of the OFC.

  4. Semantic query processing and annotation generation for content-based retrieval of histological images

    NASA Astrophysics Data System (ADS)

    Tang, Lilian H.; Hanka, Rudolf; Ip, Horace H. S.; Cheung, Kent K. T.; Lam, Ringo

    2000-05-01

    In this paper we present a semantic content representation scheme and the associated techniques for supporting (1) query by image examples or by natural language in a histological image database and (2) automatic annotation generation for images through image semantic analysis. In this research, various types of query are analyzed by either a semantic analyzer or a natural language analyzer to extract high level concepts and histological information, which are subsequently converted into an internal semantic content representation structure code-named 'Papillon.' Papillon serves not only as an intermediate representation scheme but also stores the semantic content of the image that will be used to match against the semantic index structure within the image database during query processing. During the image database population phase, all images that are going to be put into the database will go through the same processing so that every image would have its semantic content represented by a Papillon structure. Since the Papillon structure for an image contains high level semantic information of the image, it forms the basis of the technique that automatically generates textual annotation for the input images. Papillon bridges the gap between different media in the database, allows complicated intelligent browsing to be carried out efficiently, and also provides a well- defined semantic content representation scheme for different content processing engines developed for content-based retrieval.

  5. Time-bin-encoding-based remote states generation of nitrogen-vacancy centers through noisy channels

    NASA Astrophysics Data System (ADS)

    Su, Shi-Lei; Chen, Li; Guo, Qi; Wang, Hong-Fu; Zhu, Ai-Dong; Zhang, Shou

    2015-02-01

    We design proposals to generate a remote Greenberger-Horne-Zeilinger (GHZ) state and a W state of nitrogen-vacancy (NV) centers coupled to microtoroidal resonators (MTRs) through noisy channels by utilizing time-bin encoding processes and fast-optical-switch-based polarization rotation operations. The polarization and phase noise induced by noisy channels generally affect the time of state generation but not its success probability and fidelity. Besides, the above proposals can be generalized to n-qubit between two or among n remote nodes with success probability unity under ideal conditions. Furthermore, the proposals are robust for regular noise-changeable channels for the n-node case. This method is also useful in other remote quantum information processing tasks through noisy channels. Project supported by the National Natural Science Foundation of China (Grant Nos. 11264042, 61465013, 11465020, and 11165015), the Program for Chun Miao Excellent Talents of Jilin Provincial Department of Education (Grant No. 201316), and the Talent Program of Yanbian University of China (Grant No. 950010001).

  6. Vibrating-mesh nebulization of liposomes generated using an ethanol-based proliposome technology.

    PubMed

    Elhissi, Abdelbary; Gill, Hardyal; Ahmed, Waqar; Taylor, Kevin

    2011-06-01

    This is the first study that evaluates the influence of the compartmental design of the micropump Aeroneb Go nebulizer and the viscosity of a proliposome hydration medium on vibrating-mesh aerosolization of liposomes. Ethanol-based proliposomes comprising soya phosphatidylcholine and cholesterol (1:1 mole ratio) were hydrated by using isotonic NaCl (0.9%) or sucrose (9.25%) solutions to generate liposomes that entrapped approximately 61% of the hydrophilic drug, salbutamol sulphate. Liposomes were aerosolized by the nebulizer to a two-stage impinger. For both formulations, the aerosol mass output was higher than the phospholipid output, indicating some accumulation of large liposomes or liposome aggregate within the nebulizer. Using NaCl (0.9%) solution as the dispersion medium, aerosol droplet size was much smaller and aerosol mass and phospholipid outputs were higher. This was attributed to the lower viscosity of the NaCl solution, resulting in a reduced retention of the aerosols in the "trap" of the nebulizer. For the entrapped salbutamol sulphate, although the "fine particle fraction" was relatively high (57.44%), size reduction of the liposomes during nebulization caused marked losses of the drug originally entrapped. Overall, liposomes generated from proliposomes when using this nebulizer showed high nebulization output and small droplet size. However, further work is required to reduce the losses of the originally entrapped drug from liposomes. PMID:20684671

  7. Novel Two-Dimensional Mechano-Electric Generators and Sensors Based on Transition Metal Dichalcogenides

    PubMed Central

    Yu, Sheng; Eshun, Kwesi; Zhu, Hao; Li, Qiliang

    2015-01-01

    Transition metal dichalcogenides (TMDCs), such as MoS2 and WSe2, provide two-dimensional atomic crystals with semiconductor band gap. In this work, we present a design of new mechano-electric generators and sensors based on transition metal dichalcogenide nanoribbon PN junctions and heterojunctions. The mechano-electric conversion was simulated by using a first-principle calculation. The output voltage of MoS2 nanoribbon PN junction increases with strain, reaching 0.036 V at 1% strain and 0.31 V at 8% strain, much larger than the reported results. Our study indicates that the length, width and layer number of TMDC nanoribbon PN junctions have an interesting but different impact on the voltage output. Also, the results indicate that doping position and concentration only cause a small fluctuation in the output voltage. These results have been compared with the mechano-electric conversion of TMDC heterojunctions. Such novel mechano-electric generators and sensors are very attractive for applications in future self-powered, wearable electronics and systems. PMID:26238461

  8. Research and development of next generation of antibody-based therapeutics

    PubMed Central

    Li, Jing; Zhu, Zhenping

    2010-01-01

    Monoclonal antibodies (mAb) are emerging as one of the major class of therapeutic agents in the treatment of many human diseases, in particular in cancer and immunological disorders. To date, 28 mAb have been approved by the United States Food and Drug Administration for clinical applications. In addition, several hundreds of mAb are being developed clinically by many biotech and pharmaceutical companies for various disease indications. Many challenges still remain, however, and the full potential of therapeutic antibodies has yet to be realized. With the advancement of antibody engineering technologies and our further understanding of disease biology as well as antibody mechanism of action, many classes of novel antibody formats or antibody derived molecules are emerging as promising new generation therapeutics. These new antibody formats or molecules are carefully designed and engineered to acquire special features, such as improved pharmacokinetics, increased selectivity, and enhanced efficacy. These new agents may have the potential to revolutionize both our thinking and practice in the efforts to research and develop next generation antibody-based therapeutics. PMID:20694021

  9. Block Copolymer-Based Supramolecular Elastomers with High Extensibility and Large Stress Generation Capability

    NASA Astrophysics Data System (ADS)

    Noro, Atsushi; Hayashi, Mikihiro

    We prepared block copolymer-based supramolecular elastomers with high extensibility and large stress generation capability. Reversible addition fragmentation chain transfer polymerizations were conducted under normal pressure and high pressure to synthesize several large molecular weight polystyrene-b-[poly(butyl acrylate)-co-polyacrylamide]-b-polystyrene (S-Ba-S) block copolymers. Tensile tests revealed that the largest S-Ba-S with middle block molecular weight of 3140k achieved a breaking elongation of over 2000% with a maximum tensile stress of 3.6 MPa and a toughness of 28 MJ/m3 while the reference sample without any middle block hydrogen bonds, polystyrene-b-poly(butyl acrylate)-b-polystyrene with almost the same molecular weight, was merely viscous and not self-standing. Hence, incorporation of hydrogen bonds into a long soft middle block was found to be beneficial to attain high extensibility and large stress generation capability probably due to concerted combination of entropic changes and internal potential energy changes originaing from the dissociation of multiple hydrogen bonds by elongation. This work was supported by JSPS KAKENHI Grant Numbers 13J02357, 24685035, 15K13785, and 23655213 for M.H. and A.N. A.N. also expresses his gratitude for Tanaka Rubber Science & Technology Award by Enokagaku-Shinko Foundation, Japan.

  10. Self-powered electrospinning apparatus based on a hand-operated Wimshurst generator.

    PubMed

    Han, Wen-Peng; Huang, Yuan-Yuan; Yu, Miao; Zhang, Jun-Cheng; Yan, Xu; Yu, Gui-Feng; Zhang, Hong-Di; Yan, Shi-Ying; Long, Yun-Ze

    2015-03-19

    A conventional electrospinning setup cannot work without a plug (electricity supply). In this article, we report a self-powered electrospinning setup based on a hand-operated Wimshurst generator. The new device has better applicability and portability than a typical conventional electrospinning setup because it is lightweight and can work without an external power supply. Experimental parameters of the apparatus such as the minimum number of handle turns to generate enough energy to spin, rotation speed of the handle and electrospinning distance were investigated. Different polymers such as polystyrene (PS), poly(vinylidene fluoride) (PVDF), polycaprolactone (PCL) and polylactic acid (PLA) were electrospun into ultrathin fibers successfully by this apparatus. The stability, reliability, and repeatability of the new apparatus demonstrate that it can be used as not only a demonstrator for an electrospinning process, but also a beneficial complement to conventional electrospinning especially where or when without a power supply, and may be used in wound healing and rapid hemostasis, etc. PMID:25744100

  11. Refraction-Assisted Solar Thermoelectric Generator based on Phase-Change Lens.

    PubMed

    Kim, Myoung-Soo; Kim, Min-Ki; Jo, Sung-Eun; Joo, Chulmin; Kim, Yong-Jun

    2016-01-01

    Solar thermoelectric generators (STEGs), which are used for various applications, (particularly small size electronic devices), have optical concentration systems for high energy conversion efficiency. In this study, a refraction-assisted STEG (R-STEG) is designed based on phase-change materials. As the phase-change material (PCM) changes phase from solid to liquid, its refractive index and transmittance also change, resulting in changes in the refraction of the sunlight transmitted through it, and concentration of solar energy in the phase-change lens. This innovative design facilitates double focusing the solar energy through the optical lens and a phase-change lens. This mechanism resulted in the peak energy conversion efficiencies of the R-STEG being 60% and 86% higher than those of the typical STEG at solar intensities of 1 kW m(-2) and 1.5 kW m(-2), respectively. In addition, the energy stored in PCM can help to generate steady electrical energy when the solar energy was removed. This work presents significant progress regarding the optical characteristic of PCM and optical concentration systems of STEGs. PMID:27283350

  12. Refraction-Assisted Solar Thermoelectric Generator based on Phase-Change Lens

    NASA Astrophysics Data System (ADS)

    Kim, Myoung-Soo; Kim, Min-Ki; Jo, Sung-Eun; Joo, Chulmin; Kim, Yong-Jun

    2016-06-01

    Solar thermoelectric generators (STEGs), which are used for various applications, (particularly small size electronic devices), have optical concentration systems for high energy conversion efficiency. In this study, a refraction-assisted STEG (R-STEG) is designed based on phase-change materials. As the phase-change material (PCM) changes phase from solid to liquid, its refractive index and transmittance also change, resulting in changes in the refraction of the sunlight transmitted through it, and concentration of solar energy in the phase-change lens. This innovative design facilitates double focusing the solar energy through the optical lens and a phase-change lens. This mechanism resulted in the peak energy conversion efficiencies of the R-STEG being 60% and 86% higher than those of the typical STEG at solar intensities of 1 kW m‑2 and 1.5 kW m‑2, respectively. In addition, the energy stored in PCM can help to generate steady electrical energy when the solar energy was removed. This work presents significant progress regarding the optical characteristic of PCM and optical concentration systems of STEGs.

  13. Modular design and implementation of field-programmable-gate-array-based Gaussian noise generator

    NASA Astrophysics Data System (ADS)

    Li, Yuan-Ping; Lee, Ta-Sung; Hwang, Jeng-Kuang

    2016-05-01

    The modular design of a Gaussian noise generator (GNG) based on field-programmable gate array (FPGA) technology was studied. A new range reduction architecture was included in a series of elementary function evaluation modules and was integrated into the GNG system. The approximation and quantisation errors for the square root module with a first polynomial approximation were high; therefore, we used the central limit theorem (CLT) to improve the noise quality. This resulted in an output rate of one sample per clock cycle. We subsequently applied Newton's method for the square root module, thus eliminating the need for the use of the CLT because applying the CLT resulted in an output rate of two samples per clock cycle (>200 million samples per second). Two statistical tests confirmed that our GNG is of high quality. Furthermore, the range reduction, which is used to solve a limited interval of the function approximation algorithms of the System Generator platform using Xilinx FPGAs, appeared to have a higher numerical accuracy, was operated at >350 MHz, and can be suitably applied for any function evaluation.

  14. Electro-holography display using computer generated hologram of 3D objects based on projection spectra

    NASA Astrophysics Data System (ADS)

    Huang, Sujuan; Wang, Duocheng; He, Chao

    2012-11-01

    A new method of synthesizing computer-generated hologram of three-dimensional (3D) objects is proposed from their projection images. A series of projection images of 3D objects are recorded with one-dimensional azimuth scanning. According to the principles of paraboloid of revolution in 3D Fourier space and 3D central slice theorem, spectra information of 3D objects can be gathered from their projection images. Considering quantization error of horizontal and vertical directions, the spectrum information from each projection image is efficiently extracted in double circle and four circles shape, to enhance the utilization of projection spectra. Then spectra information of 3D objects from all projection images is encoded into computer-generated hologram based on Fourier transform using conjugate-symmetric extension. The hologram includes 3D information of objects. Experimental results for numerical reconstruction of the CGH at different distance validate the proposed methods and show its good performance. Electro-holographic reconstruction can be realized by using an electronic addressing reflective liquid-crystal display (LCD) spatial light modulator. The CGH from the computer is loaded onto the LCD. By illuminating a reference light from a laser source to the LCD, the amplitude and phase information included in the CGH will be reconstructed due to the diffraction of the light modulated by the LCD.

  15. A second generation of physical anthropomorphic 3D breast phantoms based on human subject data

    NASA Astrophysics Data System (ADS)

    Nolte, Adam; Kiarashi, Nooshin; Samei, Ehsan; Segars, W. P.; Lo, Joseph Y.

    2014-03-01

    Previous fabrication of anthropomorphic breast phantoms has demonstrated their viability as a model for 2D (mammography) and 3D (tomosynthesis) breast imaging systems. Further development of these models will be essential for the evaluation of breast x-ray systems. There is also the potential to use them as the ground truth in virtual clinical trials. The first generation of phantoms was segmented from human subject dedicated breast computed tomography data and fabricated into physical models using highresolution 3D printing. Two variations were made. The first was a multi-material model (doublet) printed with two photopolymers to represent glandular and adipose tissues with the greatest physical contrast available, mimicking 75% and 35% glandular tissue. The second model was printed with a single 75% glandular equivalent photopolymer (singlet) to represent glandular tissue, which can be filled independently with an adipose-equivalent material such as oil. For this study, we have focused on improving the latter, the singlet phantom. First, the temporary oil filler has been replaced with a permanent adipose-equivalent urethane-based polymer. This offers more realistic contrast as compared to the multi-material approach at the expense of air bubbles and pockets that form during the filling process. Second, microcalcification clusters have been included in the singlet model via crushed eggshells, which have very similar chemical composition to calcifications in vivo. The results from these new prototypes demonstrate significant improvement over the first generation of anthropomorphic physical phantoms.

  16. High flatness optical frequency comb generator based on the chirping of modulators

    NASA Astrophysics Data System (ADS)

    Qu, Kun; Zhao, Shanghong; Liang, Dan Ya; Zhu, Zihang; Dong, Chen; Li, Xuan

    2016-06-01

    A novel scheme for generation of an optical frequency comb (OFC) based on the chirping of two cascaded modulators is proposed. The first modulator is a dual-electrode Mach-Zehnder modulator (MZM), while the other modulator is an integrated MZM composed of two parallel MZMs that increases the number of comb lines. Our modified scheme can generate a large number of frequency lines with excellent flatness by simply modifying the chirp factor, and it is shown that up to 54 frequency lines could be observed. Theoretical analysis and simulation results show that under the variety of conditions that can be used in this scheme, the power fluctuations of the OFC lines are less than 0.5 dB in all cases; these results demonstrate the robustness of our scheme and verify its good accuracy and high stability with perfect flatness. Additionally, our modified scheme has the merit of tunable frequency spacing, which is practical for experimental realization of the OFC.

  17. Refraction-Assisted Solar Thermoelectric Generator based on Phase-Change Lens

    PubMed Central

    Kim, Myoung-Soo; Kim, Min-Ki; Jo, Sung-Eun; Joo, Chulmin; Kim, Yong-Jun

    2016-01-01

    Solar thermoelectric generators (STEGs), which are used for various applications, (particularly small size electronic devices), have optical concentration systems for high energy conversion efficiency. In this study, a refraction-assisted STEG (R-STEG) is designed based on phase-change materials. As the phase-change material (PCM) changes phase from solid to liquid, its refractive index and transmittance also change, resulting in changes in the refraction of the sunlight transmitted through it, and concentration of solar energy in the phase-change lens. This innovative design facilitates double focusing the solar energy through the optical lens and a phase-change lens. This mechanism resulted in the peak energy conversion efficiencies of the R-STEG being 60% and 86% higher than those of the typical STEG at solar intensities of 1 kW m−2 and 1.5 kW m−2, respectively. In addition, the energy stored in PCM can help to generate steady electrical energy when the solar energy was removed. This work presents significant progress regarding the optical characteristic of PCM and optical concentration systems of STEGs. PMID:27283350

  18. Optical frequency comb generation based on chirping of Mach-Zehnder Modulators

    NASA Astrophysics Data System (ADS)

    Hmood, Jassim K.; Emami, Siamak D.; Noordin, Kamarul A.; Ahmad, Harith; Harun, Sulaiman W.; Shalaby, Hossam M. H.

    2015-06-01

    A new approach for the generation of an optical frequency comb, based on chirping of modulators, is proposed and numerically demonstrated. The setup includes two cascaded Mach-Zehnder Modulators (MZMs), a sinusoidal wave oscillator, and an electrical time delay. The first MZM is driven directly by a sinusoidal wave, while the second MZM is driven by a delayed replica of the sinusoidal wave. A mathematical model of the proposed system is formulated and modeled using the Matlab software. It is shown that the number of the frequency lines is directly proportional to the chirp factor. In order to achieve the highest number of frequency comb lines with the best flatness, the time delay between the driving voltages of the two MZMs is optimized. Our results reveal that at least 51 frequency lines can be observed at the output spectrum. In addition, 27 of these lines have power fluctuations of less than 1 dB. The performance of the proposed system is also simulated using a split-step numerical analysis. An optical frequency comb, with tunable frequency spacing ranging from 5 to 40 GHz, is successfully generated.

  19. Ambient formaldehyde detection with a laser spectrometer based on difference-frequency generation in PPLN

    NASA Astrophysics Data System (ADS)

    Rehle, D.; Leleux, D.; Erdelyi, M.; Tittel, F.; Fraser, M.; Friedfeld, S.

    2001-06-01

    A laser spectrometer based on difference-frequency generation in periodically poled LiNbO3 (PPLN) has been used to quantify atmospheric formaldehyde with a detection limit of 0.32 parts per billion in a given volume (ppbV) using specifically developed data-processing techniques. With state-of-the-art fiber-coupled diode-laser pump sources at 1083 nm and 1561 nm, difference-frequency radiation has been generated in the 3.53-μm (2832-cm-1) spectral region. Formaldehyde in ambient air in the 1- to 10-ppb V range has been detected continuously for nine and five days at two separate field sites in the Greater Houston area operated by the Texas Natural Resource Conservation Commission (TNRCC) and the Houston Regional Monitoring Corporation (HRM). The acquired spectroscopic data are compared with results obtained by a well-established wet-chemical o-(2,3,4,5,6-pentafluorobenzyl) hydroxylamine (PFBHA) technique.

  20. Resolution of the mixed waste issue for EDTA-based steam generator chemical cleaning waste solutions

    SciTech Connect

    Reid, R.D.; Schneidmiller, D.

    1996-12-31

    The valence state of chromium in an EDTA-based iron oxide removal solvent waste was determined under various storage conditions. The solvent is used to remove deposits from the secondary sides of nuclear power plant steam generators and was developed under the sponsorship of the Electric Power Research Institute and the Steam Generator Owners Group. Chromium is typically present in such waste at a level greater than 5 ppm, thus creating the possibility that the waste could be subject to regulatory control as a hazardous waste under RCRA. Additionally, the waste typically contains trace levels of radioactivity, and could potentially be classified as mixed waste. In the past, interim processing has been used to reduce the chromium concentration in the waste to allow storage for greater than 90 days without the waste being subject to regulatory control. Extended storage prior to final processing and disposal is routinely required. However, the results reported clearly show that any chromium in the waste is exclusively trivalent and will remain so indefinitely under any credible storage scenario. Thus, the waste qualifies for the trivalent chromium exclusion provided under RCRA. Further, the results show that the valence state of chromium in the waste cannot be changed without extraordinary effort.

  1. Generating the Local Oscillator "Locally" in Continuous-Variable Quantum Key Distribution Based on Coherent Detection

    NASA Astrophysics Data System (ADS)

    Qi, Bing; Lougovski, Pavel; Pooser, Raphael; Grice, Warren; Bobrek, Miljko

    2015-10-01

    Continuous-variable quantum key distribution (CV-QKD) protocols based on coherent detection have been studied extensively in both theory and experiment. In all the existing implementations of CV-QKD, both the quantum signal and the local oscillator (LO) are generated from the same laser and propagate through the insecure quantum channel. This arrangement may open security loopholes and limit the potential applications of CV-QKD. In this paper, we propose and demonstrate a pilot-aided feedforward data recovery scheme that enables reliable coherent detection using a "locally" generated LO. Using two independent commercial laser sources and a spool of 25-km optical fiber, we construct a coherent communication system. The variance of the phase noise introduced by the proposed scheme is measured to be 0.04 (rad2 ), which is small enough to enable secure key distribution. This technology also opens the door for other quantum communication protocols, such as the recently proposed measurement-device-independent CV-QKD, where independent light sources are employed by different users.

  2. Novel Two-Dimensional Mechano-Electric Generators and Sensors Based on Transition Metal Dichalcogenides

    NASA Astrophysics Data System (ADS)

    Yu, Sheng; Eshun, Kwesi; Zhu, Hao; Li, Qiliang

    2015-08-01

    Transition metal dichalcogenides (TMDCs), such as MoS2 and WSe2, provide two-dimensional atomic crystals with semiconductor band gap. In this work, we present a design of new mechano-electric generators and sensors based on transition metal dichalcogenide nanoribbon PN junctions and heterojunctions. The mechano-electric conversion was simulated by using a first-principle calculation. The output voltage of MoS2 nanoribbon PN junction increases with strain, reaching 0.036 V at 1% strain and 0.31 V at 8% strain, much larger than the reported results. Our study indicates that the length, width and layer number of TMDC nanoribbon PN junctions have an interesting but different impact on the voltage output. Also, the results indicate that doping position and concentration only cause a small fluctuation in the output voltage. These results have been compared with the mechano-electric conversion of TMDC heterojunctions. Such novel mechano-electric generators and sensors are very attractive for applications in future self-powered, wearable electronics and systems.

  3. Novel Two-Dimensional Mechano-Electric Generators and Sensors Based on Transition Metal Dichalcogenides.

    PubMed

    Yu, Sheng; Eshun, Kwesi; Zhu, Hao; Li, Qiliang

    2015-01-01

    Transition metal dichalcogenides (TMDCs), such as MoS2 and WSe2, provide two-dimensional atomic crystals with semiconductor band gap. In this work, we present a design of new mechano-electric generators and sensors based on transition metal dichalcogenide nanoribbon PN junctions and heterojunctions. The mechano-electric conversion was simulated by using a first-principle calculation. The output voltage of MoS2 nanoribbon PN junction increases with strain, reaching 0.036 V at 1% strain and 0.31 V at 8% strain, much larger than the reported results. Our study indicates that the length, width and layer number of TMDC nanoribbon PN junctions have an interesting but different impact on the voltage output. Also, the results indicate that doping position and concentration only cause a small fluctuation in the output voltage. These results have been compared with the mechano-electric conversion of TMDC heterojunctions. Such novel mechano-electric generators and sensors are very attractive for applications in future self-powered, wearable electronics and systems. PMID:26238461

  4. Gigahertz frequency comb offset stabilization based on supercontinuum generation in silicon nitride waveguides.

    PubMed

    Klenner, Alexander; Mayer, Aline S; Johnson, Adrea R; Luke, Kevin; Lamont, Michael R E; Okawachi, Yoshitomo; Lipson, Michal; Gaeta, Alexander L; Keller, Ursula

    2016-05-16

    Silicon nitride (Si3N4) waveguides represent a novel photonic platform that is ideally suited for energy efficient and ultrabroadband nonlinear interactions from the visible to the mid-infrared. Chip-based supercontinuum generation in Si3N4 offers a path towards a fully-integrated and highly compact comb source for sensing and time-and-frequency metrology applications. We demonstrate the first successful frequency comb offset stabilization that utilizes a Si3N4 waveguide for octave-spanning supercontinuum generation and achieve the lowest integrated residual phase noise of any diode-pumped gigahertz laser comb to date. In addition, we perform a direct comparison to a standard silica photonic crystal fiber (PCF) using the same ultrafast solid-state laser oscillator operating at 1 µm. We identify the minimal role of Raman scattering in Si3N4 as a key benefit that allows to overcome the fundamental limitations of silica fibers set by Raman-induced self-frequency shift. PMID:27409927

  5. Spin-current-driven thermoelectric generation based on interfacial spin-orbit coupling

    NASA Astrophysics Data System (ADS)

    Yagmur, A.; Karube, S.; Uchida, K.; Kondou, K.; Iguchi, R.; Kikkawa, T.; Otani, Y.; Saitoh, E.

    2016-06-01

    The longitudinal spin Seebeck effect (SSE) in Bi2O3/Cu/yttrium-iron-garnet (YIG) devices has been investigated. When an out-of-plane temperature gradient is applied to the Bi2O3/Cu/YIG device, a spin current is generated across the Cu/YIG interface via the SSE and then converted into electric voltage due to the spin-orbit coupling at the Bi2O3/Cu interface. The sign of the SSE voltage in the Bi2O3/Cu/YIG devices is opposite to that induced by the conventional inverse spin Hall effect in Pt/YIG devices. The SSE voltage in the Bi2O3/Cu/YIG devices disappears in the absence of the Bi2O3 layer and its thermoelectric conversion efficiency is independent of the Cu thickness, indicating the important role of the Bi2O3/Cu interface. This result demonstrates that not only the bulk inverse spin Hall effect but also the spin-orbit coupling near the interface can be used for SSE-based thermoelectric generation.

  6. The generation of arbitrary vector beams using a division of a wavefront-based setup

    NASA Astrophysics Data System (ADS)

    Kalita, Ranjan; Gaffar, Md; Boruah, Bosanta R.

    2016-07-01

    In this paper, we introduce an arbitrary vector-beam-forming scheme using a simple arrangement involving only one liquid crystal spatial light modulator. An arbitrary vector beam can be obtained by overlapping two orthogonally polarized beams. In most of the existing vector-beam-forming schemes the two orthogonally polarized beams are essentially copies of a single incident wavefront. However, in the proposed scheme the two orthogonally polarized beams correspond to two separated parts of a single incident wavefront. Taking a cue from the two-beam interference phenomenon, the present scheme can be referred to as a division of a wavefront-based scheme. The proposed setup offers certain important advantages and is more suitable for the generation of higher average-power vector beams. We demonstrate the working of the vector-beam-forming scheme by generating various vector beams such as radially polarized, azimuthally polarized, and Bessel–Gauss beams and also a boat-shaped beam in the focal volume of a low-numerical-aperture focusing lens. The boat-shaped beam comprises a dark center surrounded by intense light from all but one direction. The beam is realized at the focus of an azimuthally polarized beam in the presence of a moderate amount of coma in the beam. The experimental results obtained using the proposed setup are verified by comparing them with the theoretical results.

  7. VibrioBase: a model for next-generation genome and annotation database development.

    PubMed

    Choo, Siew Woh; Heydari, Hamed; Tan, Tze King; Siow, Cheuk Chuen; Beh, Ching Yew; Wee, Wei Yee; Mutha, Naresh V R; Wong, Guat Jah; Ang, Mia Yang; Yazdi, Amir Hessam

    2014-01-01

    To facilitate the ongoing research of Vibrio spp., a dedicated platform for the Vibrio research community is needed to host the fast-growing amount of genomic data and facilitate the analysis of these data. We present VibrioBase, a useful resource platform, providing all basic features of a sequence database with the addition of unique analysis tools which could be valuable for the Vibrio research community. VibrioBase currently houses a total of 252 Vibrio genomes developed in a user-friendly manner and useful to enable the analysis of these genomic data, particularly in the field of comparative genomics. Besides general data browsing features, VibrioBase offers analysis tools such as BLAST interfaces and JBrowse genome browser. Other important features of this platform include our newly developed in-house tools, the pairwise genome comparison (PGC) tool, and pathogenomics profiling tool (PathoProT). The PGC tool is useful in the identification and comparative analysis of two genomes, whereas PathoProT is designed for comparative pathogenomics analysis of Vibrio strains. Both of these tools will enable researchers with little experience in bioinformatics to get meaningful information from Vibrio genomes with ease. We have tested the validity and suitability of these tools and features for use in the next-generation database development. PMID:25243218

  8. Generation of Potent T-cell Immunotherapy for Cancer Using DAP12-Based, Multichain, Chimeric Immunoreceptors.

    PubMed

    Wang, Enxiu; Wang, Liang-Chuan; Tsai, Ching-Yi; Bhoj, Vijay; Gershenson, Zack; Moon, Edmund; Newick, Kheng; Sun, Jing; Lo, Albert; Baradet, Timothy; Feldman, Michael D; Barrett, David; Puré, Ellen; Albelda, Steven; Milone, Michael C

    2015-07-01

    Chimeric antigen receptors (CAR) bearing an antigen-binding domain linked in cis to the cytoplasmic domains of CD3ζ and costimulatory receptors have provided a potent method for engineering T-cell cytotoxicity toward B-cell leukemia and lymphoma. However, resistance to immunotherapy due to loss of T-cell effector function remains a significant barrier, especially in solid malignancies. We describe an alternative chimeric immunoreceptor design in which we have fused a single-chain variable fragment for antigen recognition to the transmembrane and cytoplasmic domains of KIR2DS2, a stimulatory killer immunoglobulin-like receptor (KIR). We show that this simple, KIR-based CAR (KIR-CAR) triggers robust antigen-specific proliferation and effector function in vitro when introduced into human T cells with DAP12, an immunotyrosine-based activation motifs-containing adaptor. T cells modified to express a KIR-CAR and DAP12 exhibit superior antitumor activity compared with standard first- and second-generation CD3ζ-based CARs in a xenograft model of mesothelioma highly resistant to immunotherapy. The enhanced antitumor activity is associated with improved retention of chimeric immunoreceptor expression and improved effector function of isolated tumor-infiltrating lymphocytes. These results support the exploration of KIR-CARs for adoptive T-cell immunotherapy, particularly in immunotherapy-resistant solid tumors. PMID:25941351

  9. Phantom-based ground-truth generation for cerebral vessel segmentation and pulsatile deformation analysis

    NASA Astrophysics Data System (ADS)

    Schetelig, Daniel; Säring, Dennis; Illies, Till; Sedlacik, Jan; Kording, Fabian; Werner, René

    2016-03-01

    Hemodynamic and mechanical factors of the vascular system are assumed to play a major role in understanding, e.g., initiation, growth and rupture of cerebral aneurysms. Among those factors, cardiac cycle-related pulsatile motion and deformation of cerebral vessels currently attract much interest. However, imaging of those effects requires high spatial and temporal resolution and remains challenging { and similarly does the analysis of the acquired images: Flow velocity changes and contrast media inflow cause vessel intensity variations in related temporally resolved computed tomography and magnetic resonance angiography data over the cardiac cycle and impede application of intensity threshold-based segmentation and subsequent motion analysis. In this work, a flow phantom for generation of ground-truth images for evaluation of appropriate segmentation and motion analysis algorithms is developed. The acquired ground-truth data is used to illustrate the interplay between intensity fluctuations and (erroneous) motion quantification by standard threshold-based segmentation, and an adaptive threshold-based segmentation approach is proposed that alleviates respective issues. The results of the phantom study are further demonstrated to be transferable to patient data.

  10. VibrioBase: A Model for Next-Generation Genome and Annotation Database Development

    PubMed Central

    Choo, Siew Woh; Tan, Tze King; Mutha, Naresh V. R.; Wong, Guat Jah

    2014-01-01

    To facilitate the ongoing research of Vibrio spp., a dedicated platform for the Vibrio research community is needed to host the fast-growing amount of genomic data and facilitate the analysis of these data. We present VibrioBase, a useful resource platform, providing all basic features of a sequence database with the addition of unique analysis tools which could be valuable for the Vibrio research community. VibrioBase currently houses a total of 252 Vibrio genomes developed in a user-friendly manner and useful to enable the analysis of these genomic data, particularly in the field of comparative genomics. Besides general data browsing features, VibrioBase offers analysis tools such as BLAST interfaces and JBrowse genome browser. Other important features of this platform include our newly developed in-house tools, the pairwise genome comparison (PGC) tool, and pathogenomics profiling tool (PathoProT). The PGC tool is useful in the identification and comparative analysis of two genomes, whereas PathoProT is designed for comparative pathogenomics analysis of Vibrio strains. Both of these tools will enable researchers with little experience in bioinformatics to get meaningful information from Vibrio genomes with ease. We have tested the validity and suitability of these tools and features for use in the next-generation database development. PMID:25243218

  11. Scaling up explanation generation: Large-scale knowledge bases and empirical studies

    SciTech Connect

    Lester, J.C.; Porter, B.W.

    1996-12-31

    To explain complex phenomena, an explanation system must be able to select information from a formal representation of domain knowledge, organize the selected information into multisentential discourse plans, and realize the discourse plans in text. Although recent years have witnessed significant progress in the development of sophisticated computational mechanisms for explanation, empirical results have been limited. This paper reports on a seven year effort to empirically study explanation generation from semantically rich, large-scale knowledge bases. We first describe Knight, a robust explanation system that constructs multi-sentential and multi-paragraph explanations from the Biology Knowledge Base, a large-scale knowledge base in the domain of botanical anatomy, physiology, and development. We then introduce the Two Panel evaluation methodology and describe how Knight`s performance was assessed with this methodology in the most extensive empirical evaluation conducted on an explanation system. In this evaluation, Knight scored within {open_quotes}half a grade{close_quote} of domain experts, and its performance exceeded that of one of the domain experts.

  12. Pulse generators based on air-insulated linear-transformer-driver stages

    NASA Astrophysics Data System (ADS)

    Kovalchuk, B. M.; Kharlov, A. V.; Kumpyak, E. V.; Zherlitsyn, A. A.

    2013-05-01

    In this paper we present the design and test results of pulse generators based on air-insulated linear-transformer-driver stages that drive a vacuum transmission line. A custom designed unit, referred to as a capacitor block, was developed for use as a main structural element of the transformer stages. It incorporates two capacitors GA 35426 (40 nF, 100 kV) and a multichannel multigap gas switch. Two types of stages were developed: (1) stage LTD-20 with four modules in parallel and five capacitor blocks in each module (in tests of this stage current amplitude up to 850 kA with ˜140ns rise time was obtained on a 0.05Ω load at 100 kV charging voltage); (2) stage LTD-4 with two modules in parallel and two capacitor blocks in each module. Several installations were built on the base of these stages, including a linear transformer, consisting of two identical LTD-20 stages in series, and a high power electron accelerator on the base of LTD-4 stages. The design, tests results, and main problems are presented and discussed in this paper for these installations.

  13. Simulation and Optimization of the Heat Exchanger for Automotive Exhaust-Based Thermoelectric Generators

    NASA Astrophysics Data System (ADS)

    Su, C. Q.; Huang, C.; Deng, Y. D.; Wang, Y. P.; Chu, P. Q.; Zheng, S. J.

    2016-03-01

    In order to enhance the exhaust waste heat recovery efficiency of the automotive exhaust-based thermoelectric generator (TEG) system, a three-segment heat exchanger with folded-shaped internal structure for the TEG system is investigated in this study. As the major effect factors of the performance for the TEG system, surface temperature, and thermal uniformity of the heat exchanger are analyzed in this research, pressure drop along the heat exchanger is also considered. Based on computational fluid dynamics simulations and temperature distribution, the pressure drop along the heat exchanger is obtained. By considering variable length and thickness of folded plates in each segment of the heat exchanger, response surface methodology and optimization by a multi-objective genetic algorithm is applied for surface temperature, thermal uniformity, and pressure drop for the folded-shaped heat exchanger. An optimum design based on the optimization is proposed to improve the overall performance of the TEG system. The performance of the optimized heat exchanger in different engine conditions is discussed.

  14. Ferroelectric HfO2-based materials for next-generation ferroelectric memories

    NASA Astrophysics Data System (ADS)

    Fan, Zhen; Chen, Jingsheng; Wang, John

    2016-05-01

    Ferroelectric random access memory (FeRAM) based on conventional ferroelectric perovskites, such as Pb(Zr,Ti)O3 and SrBi2Ta2O9, has encountered bottlenecks on memory density and cost, because those conventional perovskites suffer from various issues mainly including poor complementary metal-oxide-semiconductor (CMOS)-compatibility and limited scalability. Next-generation cost-efficient, high-density FeRAM shall therefore rely on a material revolution. Since the discovery of ferroelectricity in Si:HfO2 thin films in 2011, HfO2-based materials have aroused widespread interest in the field of FeRAM, because they are CMOS-compatible and can exhibit robust ferroelectricity even when the film thickness is scaled down to below 10 nm. A review on this new class of ferroelectric materials is therefore of great interest. In this paper, the most appealing topics about ferroelectric HfO2-based materials including origins of ferroelectricity, advantageous material properties, and current and potential applications in FeRAM, are briefly reviewed.

  15. Hybrid scheduling mechanisms for Next-generation Passive Optical Networks based on network coding

    NASA Astrophysics Data System (ADS)

    Zhao, Jijun; Bai, Wei; Liu, Xin; Feng, Nan; Maier, Martin

    2014-10-01

    Network coding (NC) integrated into Passive Optical Networks (PONs) is regarded as a promising solution to achieve higher throughput and energy efficiency. To efficiently support multimedia traffic under this new transmission mode, novel NC-based hybrid scheduling mechanisms for Next-generation PONs (NG-PONs) including energy management, time slot management, resource allocation, and Quality-of-Service (QoS) scheduling are proposed in this paper. First, we design an energy-saving scheme that is based on Bidirectional Centric Scheduling (BCS) to reduce the energy consumption of both the Optical Line Terminal (OLT) and Optical Network Units (ONUs). Next, we propose an intra-ONU scheduling and an inter-ONU scheduling scheme, which takes NC into account to support service differentiation and QoS assurance. The presented simulation results show that BCS achieves higher energy efficiency under low traffic loads, clearly outperforming the alternative NC-based Upstream Centric Scheduling (UCS) scheme. Furthermore, BCS is shown to provide better QoS assurance.

  16. Generation of Potent T-cell Immunotherapy for Cancer using DAP12-based, Multichain, Chimeric Immunoreceptors

    PubMed Central

    Wang, Enxiu; Wang, Liang-Chuan; Tsai, Ching-Yi; Bhoj, Vijay; Gershenson, Zack; Moon, Edmund; Newick, Kheng; Sun, Jing; Lo, Albert; Baradet, Timothy; Feldman, Michael D.; Barrett, David; Puré, Ellen; Albelda, Steven; Milone, Michael C.

    2015-01-01

    Chimeric antigen receptors (CAR) bearing an antigen-binding domain linked in cis to the cytoplasmic domains of CD3ζ and costimulatory receptors have provided a potent method for engineering T-cell cytotoxicity towards B-cell leukemia and lymphoma. However, resistance to immunotherapy due to loss of T-cell effector function remains a significant barrier, especially in solid malignancies. We describe an alternative chimeric immunoreceptor design in which we have fused a single-chain variable fragment for antigen recognition to the transmembrane and cytoplasmic domains of KIR2DS2, a stimulatory killer immunoglobulin-like receptor (KIR). We show that this simple, KIR-based CAR (KIR-CAR) triggers robust antigen-specific proliferation and effector function in vitro when introduced into human T cells with DAP12, an immunotyrosine-based activation motifs (ITAM)-containing adaptor. T cells modified to express a KIR-CAR and DAP12 exhibit superior antitumor activity compared to standard first and second generation CD3ζ-based CARs in a xenograft model of mesothelioma highly resistant to immunotherapy. The enhanced antitumor activity is associated with improved retention of chimeric immunoreceptor expression and improved effector function of isolated tumor-infiltrating lymphocytes. These results support the exploration of KIR-CARs for adoptive T-cell immunotherapy, particularly in immunotherapy-resistant solid tumors. PMID:25941351

  17. Gallium-68 PET: A Powerful Generator-based Alternative to Infection and Inflammation Imaging.

    PubMed

    Vorster, Mariza; Maes, Alex; Wiele, Christophe van de; Sathekge, Mike

    2016-09-01

    The process of inflammation (with or without infection) forms part of essentially every major debilitating disease. Early detection and accurate distinction of inflammation from infection are important to optimize and individualize therapy. Nuclear medicine is ideally suited for the detection of pathologic changes early on and is able to target a magnitude of role players involved in the aforementioned processes. Hybrid modalities such as PET/CT and PET/MRI offer high spatial resolution that combines morphologic and pathophysiological changes and add various quantification possibilities that are preferable in these settings. It follows then that the development of PET radiopharmaceuticals is imperative to make use of these latest advances. Gallium-68 (Ga-68)-based tracers are exceptionally well suited to these indications, considering the year-round availability from a single generator, the relative cost-effectiveness, and relative ease of labeling. Over the past few years, the development of Ga-68-based tracers has understandably exploded with a recent growing interest in infection and inflammation imaging. This review aims to highlight some of the most important and interesting advances made with Ga-68-based PET/CT in the field of infection and inflammation imaging. PMID:27553469

  18. Transmission Disequilibrium Tests Based on Read Counts for Low-Coverage Next-Generation Sequence Data.

    PubMed

    Kim, Wonkuk

    2015-01-01

    The purpose of this paper is the introduction of new statistical methods for case-parent trio association studies based on the read counts that can be obtained from next-generation sequencing (NGS) experiments. This work focuses on the inclusion of low-coverage data into the case-parent trio design without genotype classification or imputation. Two different approaches are considered: (1) a likelihood-based approach implementing a 15-component parametric mixture model and (2) a model-free approach that applies non-parametric statistical methods to the ratios of the read counts to coverage. Simulation studies are conducted to evaluate the performances of the proposed tests. In addition, the non-centrality parameters of the mixture likelihood-based tests are derived to determine sample sizes and coverage for a NGS experimental design. As an example, the sample sizes to maintain specified powers of a published adolescent idiopathic scoliosis (AIS) study are presented. The simulation results show that the tests using the genotypes classified by the maximum Bayesian posterior probability have significantly inflated type I error rates for low-coverage data. The tests using the posterior probabilities instead of the classified genotypes show lower power than the proposed tests. Generally, power for the likelihood-based approach is higher than that for the non-parametric ratio-based approach. For the AIS example, approximately 654 trios with 4× coverage are necessary to maintain 90% power when detecting an association of odds ratio 2 at a locus with a minor allele frequency of 0.35 at the level of significance α = 5 × 10(-8). By comparison, approximately 416 trios with 25× coverage are required to maintain the same power with the same settings. The R and C source codes to calculate the proposed test statistics, the sample sizes and power can be obtained by contacting the author (wkim@cau.ac.kr). PMID:26278553

  19. GaN-Based Detector Enabling Technology for Next Generation Ultraviolet Planetary Missions

    NASA Technical Reports Server (NTRS)

    Aslam, S.; Gronoff, G.; Hewagama, T.; Janz, S.; Kotecki, C.

    2012-01-01

    The ternary alloy AlN-GaN-InN system provides several distinct advantages for the development of UV detectors for future planetary missions. First, (InN), (GaN) and (AlN) have direct bandgaps 0.8, 3.4 and 6.2 eV, respectively, with corresponding wavelength cutoffs of 1550 nm, 365 nm and 200 nm. Since they are miscible with each other, these nitrides form complete series of indium gallium nitride (In(sub l-x)Ga(sub x)N) and aluminum gallium nitride (Al(sub l-x)Ga(sub x)N) alloys thus allowing the development of detectors with a wavelength cut-off anywhere in this range. For the 2S0-365 nm spectral wavelength range AlGaN detectors can be designed to give a 1000x solar radiation rejection at cut-off wavelength of 325 nm, than can be achieved with Si based detectors. For tailored wavelength cut-offs in the 365-4S0 nm range, InGaN based detectors can be fabricated, which still give 20-40x better solar radiation rejection than Si based detectors. This reduced need for blocking filters greatly increases the Detective Quantum efficiency (DQE) and simplifies the instrument's optical systems. Second, the wide direct bandgap reduces the thermally generated dark current to levels allowing many observations to be performed at room temperature. Third, compared to narrow bandgap materials, wide bandgap semiconductors are significantly more radiation tolerant. Finally, with the use of an (AI, In)GaN array, the overall system cost is reduced by eliminating stringent Si CCD cooling systems. Compared to silicon, GaN based detectors have superior QE based on a direct bandgap and longer absorption lengths in the UV.

  20. Statistical framework for detection of genetically modified organisms based on Next Generation Sequencing.

    PubMed

    Willems, Sander; Fraiture, Marie-Alice; Deforce, Dieter; De Keersmaecker, Sigrid C J; De Loose, Marc; Ruttink, Tom; Herman, Philippe; Van Nieuwerburgh, Filip; Roosens, Nancy

    2016-02-01

    Because the number and diversity of genetically modified (GM) crops has significantly increased, their analysis based on real-time PCR (qPCR) methods is becoming increasingly complex and laborious. While several pioneers already investigated Next Generation Sequencing (NGS) as an alternative to qPCR, its practical use has not been assessed for routine analysis. In this study a statistical framework was developed to predict the number of NGS reads needed to detect transgene sequences, to prove their integration into the host genome and to identify the specific transgene event in a sample with known composition. This framework was validated by applying it to experimental data from food matrices composed of pure GM rice, processed GM rice (noodles) or a 10% GM/non-GM rice mixture, revealing some influential factors. Finally, feasibility of NGS for routine analysis of GM crops was investigated by applying the framework to samples commonly encountered in routine analysis of GM crops. PMID:26304412