Science.gov

Sample records for beauty particles

  1. Particle identification for beauty physics

    SciTech Connect

    Ludlam, T.

    1987-01-01

    We look briefly at the requirements for particle identification for possible beauty experiments at the Tevatron, both in the fixed target and the collider mode. Techniques presently in use in high energy physics experiments, and under development, should make sensitive experiments feasible. However, in all cases the present state of the art must be advanced to meet the necessary requirements for segmentation andor rate capability. The most fundamentally difficult challenges appear to be the efficient tagging of soft electrons (for the collider experiment) and the need to handle interaction rates up to /approximately/ 10/sub 9/ HZ in the fixed target mode. In both cases we can find ''in principle'' demonstrations that the requirements can be met. We have considered only the most basic prooperties of detectors, however, and the real answers will come from careful studies of details. 20 refs., 10 figs.

  2. Beauty is distractive: particle production during multifield inflation

    SciTech Connect

    Battefeld, Diana; Battefeld, Thorsten; Byrnes, Christian; Langlois, David E-mail: tbattefe@astro.physik.uni-goettingen.de E-mail: langlois@apc.univ-paris7.fr

    2011-08-01

    We consider a two-dimensional model of inflation, where the inflationary trajectory is ''deformed'' by a grazing encounter with an Extra Species/Symmetry Point (ESP) after the observable cosmological scales have left the Hubble radius. The encounter entails a sudden production of particles, whose backreaction causes a bending of the trajectory and a temporary decrease in speed, both of which are sensitive to initial conditions. This ''modulated'' effect leads to an additional contribution to the curvature perturbation, which can be dominant if the encounter is close. We compute associated non-Gaussianities, the bispectrum and its scale dependence as well as the trispectrum, which are potentially detectable in many cases. In addition, we consider a direct modulation of the coupling to the light field at the ESP via a modulaton field, a mixed scenario whereby the modulaton is identified with a second inflaton, and an extended Extra Species Locus (ESL); all of these scenarios lead to similar additional contributions to observables. We conclude that inflaton interactions throughout inflation are strongly constrained if primordial non-Gaussianities remain unobserved in current experiments such as PLANCK. If they are observed, an ESP encounter leaves additional signatures on smaller scales which may be used to identify the model.

  3. Beauty is more attractive: particle production andmoduli trapping with higher dimensional interaction

    NASA Astrophysics Data System (ADS)

    Enomoto, Seishi; Iida, Satoshi; Maekawa, Nobuhiro; Matsuda, Tomohiro

    2014-01-01

    We study quantum effects on moduli dynamics arising from particle production near the enhanced symmetry point (ESP). We focus on non-renormalizable couplings between the moduli field and the field that becomes light at the ESP. Considering higher dimensional interaction, we find that particle production is significant in a large area, which is even larger than the area that is expected from a renormalizable interaction. It is possible to find this possibility from a trivial adiabatic condition; however the quantitative estimation of particle production and trapping of the field in motion are far from trivial. In this paper we study particle production and trapping in detail, using both the analytical and numerical calculations, to find a clear and intuitive result that supports trapping in a vast variety of theories. Our study shows that trapping driven by a non-renormalizable interaction is possible. This possibility has not been considered in previous works. Some phenomenological models of particle physics will be mentioned to complement discussion.

  4. Small Explorers - Small is beautiful. [Solar, Anomalous, and Magnetospheric Particles Explorer (SAMPEX)

    NASA Technical Reports Server (NTRS)

    Gilman, David

    1990-01-01

    NASA's Small Explorer Program aims to achieve a flight rate of one mission per year in a program of small scientific satellites launched from small expendable launch vehicles. The Program is developing 3 missions for launch in the early 1990's: the Solar, Anomalous, and Magnetospheric Particle Explorer (SAMPEX), the Submillimeter Wave Astronomy Satellite (SWAS), and the Fast Auroral Snapshot Explorer (FAST). This paper gives an overview of the program, a description of the selected missions, the approach to developing the missions and the plans for the next Announcement of Opportunity.

  5. Beautiful equations

    NASA Astrophysics Data System (ADS)

    Viljamaa, Panu; Jacobs, J. Richard; Chris; JamesHyman; Halma, Matthew; EricNolan; Coxon, Paul

    2014-07-01

    In reply to a Physics World infographic (part of which is given above) about a study showing that Euler's equation was deemed most beautiful by a group of mathematicians who had been hooked up to a functional magnetic-resonance image (fMRI) machine while viewing mathematical expressions (14 May, http://ow.ly/xHUFi).

  6. Measurement of charm and beauty production at central rapidity versus charged-particle multiplicity in proton-proton collisions at √{s}=7 TeV

    NASA Astrophysics Data System (ADS)

    Adam, J.; Adamová, D.; Aggarwal, M. M.; Aglieri Rinella, G.; Agnello, M.; Agrawal, N.; Ahammed, Z.; Ahmed, I.; Ahn, S. U.; Aimo, I.; Aiola, S.; Ajaz, M.; Akindinov, A.; Alam, S. N.; Aleksandrov, D.; Alessandro, B.; Alexandre, D.; Alfaro Molina, R.; Alici, A.; Alkin, A.; Alme, J.; Alt, T.; Altinpinar, S.; Altsybeev, I.; Alves Garcia Prado, C.; Andrei, C.; Andronic, A.; Anguelov, V.; Anielski, J.; Antičić, T.; Antinori, F.; Antonioli, P.; Aphecetche, L.; Appelshäuser, H.; Arcelli, S.; Armesto, N.; Arnaldi, R.; Aronsson, T.; Arsene, I. C.; Arslandok, M.; Augustinus, A.; Averbeck, R.; Azmi, M. D.; Bach, M.; Badalà, A.; Baek, Y. W.; Bagnasco, S.; Bailhache, R.; Bala, R.; Baldisseri, A.; Ball, M.; Baltasar Dos Santos Pedrosa, F.; Baral, R. C.; Barbano, A. M.; Barbera, R.; Barile, F.; Barnaföldi, G. G.; Barnby, L. S.; Barret, V.; Bartalini, P.; Bartke, J.; Bartsch, E.; Basile, M.; Bastid, N.; Basu, S.; Bathen, B.; Batigne, G.; Batista Camejo, A.; Batyunya, B.; Batzing, P. C.; Bearden, I. G.; Beck, H.; Bedda, C.; Behera, N. K.; Belikov, I.; Bellini, F.; Bello Martinez, H.; Bellwied, R.; Belmont, R.; Belmont-Moreno, E.; Belyaev, V.; Bencedi, G.; Beole, S.; Berceanu, I.; Bercuci, A.; Berdnikov, Y.; Berenyi, D.; Bertens, R. A.; Berzano, D.; Betev, L.; Bhasin, A.; Bhat, I. R.; Bhati, A. K.; Bhattacharjee, B.; Bhom, J.; Bianchi, L.; Bianchi, N.; Bianchin, C.; Bielčík, J.; Bielčíková, J.; Bilandzic, A.; Biswas, S.; Bjelogrlic, S.; Blanco, F.; Blau, D.; Blume, C.; Bock, F.; Bogdanov, A.; Bøggild, H.; Boldizsár, L.; Bombara, M.; Book, J.; Borel, H.; Borissov, A.; Borri, M.; Bossú, F.; Botje, M.; Botta, E.; Böttger, S.; Braun-Munzinger, P.; Bregant, M.; Breitner, T.; Broker, T. A.; Browning, T. A.; Broz, M.; Brucken, E. J.; Bruna, E.; Bruno, G. E.; Budnikov, D.; Buesching, H.; Bufalino, S.; Buncic, P.; Busch, O.; Buthelezi, Z.; Buxton, J. T.; Caffarri, D.; Cai, X.; Caines, H.; Calero Diaz, L.; Caliva, A.; Calvo Villar, E.; Camerini, P.; Carena, F.; Carena, W.; Castillo Castellanos, J.; Castro, A. J.; Casula, E. A. R.; Cavicchioli, C.; Ceballos Sanchez, C.; Cepila, J.; Cerello, P.; Chang, B.; Chapeland, S.; Chartier, M.; Charvet, J. L.; Chattopadhyay, S.; Chattopadhyay, S.; Chelnokov, V.; Cherney, M.; Cheshkov, C.; Cheynis, B.; Chibante Barroso, V.; Chinellato, D. D.; Chochula, P.; Choi, K.; Chojnacki, M.; Choudhury, S.; Christakoglou, P.; Christensen, C. H.; Christiansen, P.; Chujo, T.; Chung, S. U.; Cicalo, C.; Cifarelli, L.; Cindolo, F.; Cleymans, J.; Colamaria, F.; Colella, D.; Collu, A.; Colocci, M.; Conesa Balbastre, G.; Conesa del Valle, Z.; Connors, M. E.; Contreras, J. G.; Cormier, T. M.; Corrales Morales, Y.; Cortés Maldonado, I.; Cortese, P.; Cosentino, M. R.; Costa, F.; Crochet, P.; Cruz Albino, R.; Cuautle, E.; Cunqueiro, L.; Dahms, T.; Dainese, A.; Danu, A.; Das, D.; Das, I.; Das, S.; Dash, A.; Dash, S.; De, S.; De Caro, A.; de Cataldo, G.; de Cuveland, J.; De Falco, A.; De Gruttola, D.; De Marco, N.; De Pasquale, S.; Deloff, A.; Dénes, E.; D'Erasmo, G.; Di Bari, D.; Di Mauro, A.; Di Nezza, P.; Diaz Corchero, M. A.; Dietel, T.; Dillenseger, P.; Divià, R.; Djuvsland, Ø.; Dobrin, A.; Dobrowolski, T.; Domenicis Gimenez, D.; Dönigus, B.; Dordic, O.; Dubey, A. K.; Dubla, A.; Ducroux, L.; Dupieux, P.; Ehlers, R. J.; Elia, D.; Engel, H.; Erazmus, B.; Eschweiler, D.; Espagnon, B.; Estienne, M.; Esumi, S.; Evans, D.; Evdokimov, S.; Eyyubova, G.; Fabbietti, L.; Fabris, D.; Faivre, J.; Fantoni, A.; Fasel, M.; Feldkamp, L.; Felea, D.; Feliciello, A.; Feofilov, G.; Ferencei, J.; Fernández Téllez, A.; Ferreiro, E. G.; Ferretti, A.; Festanti, A.; Figiel, J.; Figueredo, M. A. S.; Filchagin, S.; Finogeev, D.; Fionda, F. M.; Fiore, E. M.; Fleck, M. G.; Floris, M.; Foertsch, S.; Foka, P.; Fokin, S.; Fragiacomo, E.; Francescon, A.; Frankenfeld, U.; Fuchs, U.; Furget, C.; Furs, A.; Fusco Girard, M.; Gaardhøje, J. J.; Gagliardi, M.; Gago, A. M.; Gallio, M.; Gangadharan, D. R.; Ganoti, P.; Gao, C.; Garabatos, C.; Garcia-Solis, E.; Gargiulo, C.; Gasik, P.; Germain, M.; Gheata, A.; Gheata, M.; Ghosh, P.; Ghosh, S. K.; Gianotti, P.; Giubellino, P.; Giubilato, P.; Gladysz-Dziadus, E.; Glässel, P.; Gomez Ramirez, A.; González-Zamora, P.; Gorbunov, S.; Görlich, L.; Gotovac, S.; Grabski, V.; Graczykowski, L. K.; Grelli, A.; Grigoras, A.; Grigoras, C.; Grigoriev, V.; Grigoryan, A.; Grigoryan, S.; Grinyov, B.; Grion, N.; Grosse-Oetringhaus, J. F.; Grossiord, J.-Y.; Grosso, R.; Guber, F.; Guernane, R.; Guerzoni, B.; Gulbrandsen, K.; Gulkanyan, H.; Gunji, T.; Gupta, A.; Gupta, R.; Haake, R.; Haaland, Ø.; Hadjidakis, C.; Haiduc, M.; Hamagaki, H.; Hamar, G.; Hanratty, L. D.; Hansen, A.; Harris, J. W.; Hartmann, H.; Harton, A.; Hatzifotiadou, D.; Hayashi, S.; Heckel, S. T.; Heide, M.

    2015-09-01

    Prompt D meson and non-prompt J/ ψ yields are studied as a function of the multiplicity of charged particles produced in inelastic proton-proton collisions at a centre-of-mass energy of √{s}=7 TeV. The results are reported as a ratio between yields in a given multiplicity interval normalised to the multiplicity-integrated ones (relative yields). They are shown as a function of the multiplicity of charged particles normalised to the average value for inelastic collisions (relative charged-particle multiplicity). D0, D+ and D*+ mesons are measured in five p T intervals from 1 GeV/ c to 20 GeV/ c and for | y| < 0.5 via their hadronic decays. The D-meson relative yield is found to increase with increasing charged-particle multiplicity. For events with multiplicity six times higher than the average multiplicity of inelastic collisions, a yield enhancement of a factor about 15 relative to the multiplicity-integrated yield in inelastic collisions is observed. The yield enhancement is independent of transverse momentum within the uncertainties of the measurement. The D0-meson relative yield is also measured as a function of the relative multiplicity at forward pseudo-rapidity. The non-prompt J/ ψ, i.e. the B hadron, contribution to the inclusive J/ ψ production is measured in the di-electron decay channel at central rapidity. It is evaluated for p T > 1.3 GeV/c and | y| < 0.9, and extrapolated to p T > 0. The fraction of non-prompt J/ ψ in the inclusive J/ ψ yields shows no dependence on the charged-particle multiplicity at central rapidity. Charm and beauty hadron relative yields exhibit a similar increase with increasing charged-particle multiplicity. The measurements are compared to PYTHIA 8, EPOS 3 and percolation calculations. [Figure not available: see fulltext.

  7. The beauty mystique.

    PubMed

    Synnott, Anthony

    2006-08-01

    Physical beauty is symbolic, and a highly valued and powerful attribute, of the self. Yet it is also controversial--its value negated as a myth by many proverbs, religious authorities, and feminists alike. Here we explore some of the practices of beauty, from beauty competitions to cosmetic surgery, and also some of the thinking about beauty from Homer and Plato through Darwin and Freud to PEOPLE magazine. The beauty mystique, defined here as the widespread equation of beauty with goodness, together with other virtues imputed to beauty, has the reverse application to ugliness. Both processes are evident in our literature, media, popular culture, and our attitudes and behaviors; both are applied primarily to the face--the principal locus of both beauty and character. The mystique and the myth have their value and their limits. PMID:17048156

  8. Beauty production at CDF

    SciTech Connect

    Shears, Tara; /Liverpool U.

    2008-04-01

    A review of recent measurements of beauty production, based on proton antiproton collision data at {radical}s = 1.96 TeV and using the CDF detector, is given. Previous measurements of beauty (b) quark production at the Tevatron, carried out at centre-of-mass energies {radical}s = 1.8 TeV, have shown discrepancies when compared to Next to Leading Order (NLO) predictions [1]. Improved predictions and experimental procedures have reduced this discrepancy [2]. Improved parton density functions, better fragmentation functions and more complete theoretical calculations have improved theoretical accuracy. Experimentally, measurements of beauty production at {radical}s = 1.96 TeV are now presented in terms of b hadrons or B mesons, to avoid problems unfolding back to the quark level. In this review [3] measurements of inclusive beauty (where one beauty jet or hadron is reconstructed in the event), and beauty + X (where X can be a boson or another beauty jet or hadron), production will be presented: inclusive beauty jet cross-section; semi and fully reconstructed B meson cross-section; beauty dijet cross-section; semi-reconstructed B B meson cross-section; Z boson + beauty jet cross-section. More information concerning other measurements of heavy quark production can be found elsewhere [4].

  9. Free Beauty, Dependent Beauty, and Art.

    ERIC Educational Resources Information Center

    Stecker, Robert

    1987-01-01

    Explains the difference between free and dependent beauty. States that these distinctions, formed by Immanuel Kant, have important implications for aesthetic education. Concludes with a defense of Kant's aesthetics. (JDH)

  10. Beauty production at HERA

    SciTech Connect

    Yagues, A.

    2009-12-17

    Beauty quark production in ep collisions is being studied at HERA. The latest results in deep inelastic scattering (DIS) and photoproduction (PHP) regime performed by the ZEUS and HI experiments are presented here. The first measurement exploits the potential of the ZEUS mi-crovertex detector to identify beauty in PHP dijet events in an inclusive analysis. In the second measurement, beauty quarks were identified through their decays into muons. Finally, two measurements of the beauty contribution to the proton structure function, F{sub 2}{sup b???b}, in DIS are presented. The four measurements are consistent with previous results and are reasonably well described by QCD predictions.

  11. Beauty in the Breakdown

    ERIC Educational Resources Information Center

    Brisco, Nicole

    2008-01-01

    Most human beings look at erosion as the destruction of a surface, but artists can see that erosion often creates indefinable beauty. Where do you see beauty in the breakdown? In this article, the author presents an innovative lesson that would allow students to observe both human and physical nature. In this activity students will create a work…

  12. Musings about Beauty

    ERIC Educational Resources Information Center

    Kintsch, Walter

    2012-01-01

    In this essay, I explore how cognitive science could illuminate the concept of beauty. Two results from the extensive literature on aesthetics guide my discussion. As the term "beauty" is overextended in general usage, I choose as my starting point the notion of "perfect form." Aesthetic theorists are in reasonable agreement about the criteria for…

  13. Beauty and Hope: A Moral Beauty Intervention

    ERIC Educational Resources Information Center

    Diessner, Rhett; Rust, Teri; Solom, Rebecca C.; Frost, Nellie; Parsons, Lucas

    2006-01-01

    Pedagogical intervention regarding engagement with natural, artistic and moral beauty can lead to an increase in trait hope. In a quasi-experimental design with college students the intervention group showed significantly higher gain scores on trait hope than did the comparison group; the effect size was moderate. The experimental group also…

  14. Fixed Target Beauty Physics Experimental Programs

    SciTech Connect

    Garbincius, P.H.

    1987-11-01

    The current and near term future fixed target physics efforts in observing particles with open beauty are reviewed. This includes a compilation of the non-observation upper limits and the observation of both upsilon and b-states. A short discussion of the theoretical predictions for the hadro-produced beauty pairs is included. The major part of this review is devoted to the techniques and tricks employed, a survey of the current and proposed experiments. A personal summary of the experimental prospects concludes this report. 28 refs., 26 figs.

  15. Musings about beauty.

    PubMed

    Kintsch, Walter

    2012-01-01

    In this essay, I explore how cognitive science could illuminate the concept of beauty. Two results from the extensive literature on aesthetics guide my discussion. As the term "beauty" is overextended in general usage, I choose as my starting point the notion of "perfect form." Aesthetic theorists are in reasonable agreement about the criteria for perfect form. What do these criteria imply for mental representations that are experienced as beautiful? Complexity theory can be used to specify constraints on mental representations abstractly formulated as vectors in a high-dimensional space. A central feature of the proposed model is that perfect form depends both on features of the objects or events perceived and on the nature of the encoding strategies or model of the observer. A simple example illustrates the proposed calculations. A number of interesting implications that arise as a consequence of reformulating beauty in this way are noted. PMID:22303897

  16. Beauty and charm production at fixed-target experiments

    SciTech Connect

    Erik E. Gottschalk

    2003-12-10

    Fixed-target experiments continue to provide insights into the physics of particle production in strong interactions. The experiments are performed with different types of beam particles of varying energies, and many different target materials. Studies of beauty and charm production are of particular interest, since experimental results can be compared to perturbative QCD calculations. It is in this context that recent results from fixed-target experiments on beauty and charm production will be reviewed.

  17. The changing face of beauty.

    PubMed

    Romm, S

    1989-01-01

    Beautiful faces, like clothing and body conformation, go in and out of fashion. Yet, certain women in every era are considered truly beautiful. Who, then, sets standards of facial beauty and how are women chosen as representative of an ideal? Identifying great beauties is easier than explaining why they are chosen, but answers to these elusive questions are suggested in art, literature, and a review of past events. PMID:2662717

  18. Who Engages with Moral Beauty?

    ERIC Educational Resources Information Center

    Diessner, Rhett; Iyer, Ravi; Smith, Meghan M.; Haidt, Jonathan

    2013-01-01

    Aristotle considered moral beauty to be the "telos" of the human virtues. Displays of moral beauty have been shown to elicit the moral emotion of elevation and cause a desire to become a better person and to engage in prosocial behavior. Study 1 ("N" = 5380) shows engagement with moral beauty is related to several psychological…

  19. Is a tan really beautiful?

    PubMed

    Salpietro, B J; Del Campo, D V

    1995-12-01

    History has demonstrated many dangerous beauty fads, including tanning, which have evolved into a false concept of beauty. A teaching tool, which emphasizes tanning as just a fashion trend rather than a beauty enhancer, can help discourage people from suntanning their skin. PMID:8703606

  20. On Disinterestedness and Beauty

    ERIC Educational Resources Information Center

    Kant, Immanuel

    2005-01-01

    This article discusses disinterestedness and beauty. To apprehend a regular and appropriate building with one's cognitive faculties, be the mode of representation clear or confused, is quite a different thing from being conscious of this representation with an accompanying sensation of delight. Here the representation is referred wholly to the…

  1. The Beauty of Geometry

    ERIC Educational Resources Information Center

    Morris, Barbara H.

    2004-01-01

    This article describes a geometry project that used the beauty of stained-glass-window designs to teach middle school students about geometric figures and concepts. Three honors prealgebra teachers and a middle school mathematics gifted intervention specialist created a geometry project that covered the curriculum and also assessed students'…

  2. "Soccer": The Beautiful Game

    ERIC Educational Resources Information Center

    Spires, Todd

    2008-01-01

    Soccer, or football as it is called in the rest of the world, is the most popular and fastest-growing global sport, with an estimated 240 million people regularly playing what Brazilian star Pele called "the beautiful game." Millions, worldwide, watch it on television. In 2006, the average viewership for each match of the month-long World Cup was…

  3. Lesbians discuss beauty and aging.

    PubMed

    Thompson, K M; Brown, N; Cassidy, J; Gentry, J H

    1999-01-01

    ABSTRACT Two conversations with three aging lesbians are presented to identify and explore different definitions of beauty and how these definitions change and are influenced by age. The three women interviewed believe beauty is more than skin deep, yet they differ regarding specific components of beauty. Two believe that their definition of beauty has changed as they age and one believes that her definition has remained basically unchanged through the years. Topics of discussion include: beauty role models, the impact of the American beauty standard on their self-esteem, and what they look for in potential partners. Through these women's diverse opinions on how beauty is defined and experienced by older lesbians, we see that there is no one perspective representing all older women. PMID:24786423

  4. XMM flying beautifully

    NASA Astrophysics Data System (ADS)

    1999-12-01

    The early orbit phase came to an end on 16 December after XMM had been manoeuvred to its final orbit. This required four firings of its thrusters, on successive passages at apogee, in order to increase XMM's velocity, thus elongating its orbit and raising the perigee from 826 km to 7,365 km. One burn was then made to fine tune the apogee to around 114,000km. The spacecraft, being tracked by ground stations in Perth, Kourou and Villafranca, is now circling the Earth in this highly elliptical orbit once every 48 hours. The XMM flight operations staff have found themselves controlling a spacecraft that responds exceptionally well. During these first orbits, the satellite has been oriented several times with razor-sharp precision. On board systems have responded without incident to several thousand instructions sent by controllers. "XMM is flying so beautifully" says Dietmar Heger, XMM Spacecraft Operations Manager. "The satellite is behaving better in space than all our pre-launch simulations and we have been able to adjust our shifts to this more relaxed situation". On his return from French Guiana, Robert Lainé, XMM Project Manager immediately visited the Darmstadt Mission Control Centre, at ESOC. "The perfect behaviour of XMM at this early stage reflects the constructive cooperation of European industrial companies and top scientists. Spacecraft operations are in the hands of professionals who will endeavour to fulfill the expectations of the astronomers and astrophysicists of the world. I am very happy that ESA could provide them with such a wonderful precision tool". During the early orbit phase, controllers have activated part of XMM's science payload. The three EPIC X-ray cameras have been switched on and vented. On 17 December the telescope doors were opened allowing the spacecraft's golden X-ray Multi Mirror modules to see the sky. The Optical Monitor telescope door was opened on 18 December. During this last weekend, XMM's Radiation Monitor which records

  5. The face, beauty, and symmetry: perceiving asymmetry in beautiful faces.

    PubMed

    Zaidel, D W; Cohen, J A

    2005-08-01

    The relationship between bilateral facial symmetry and beauty remains to be clarified. Here, straight head-on photographs of "beautiful" faces from the collections of professional modeling agencies were selected. First, beauty ratings were obtained for these faces. Then, the authors created symmetrical left-left and right-right composites of the beautiful faces and asked a new group of subjects to choose the most attractive pair member. "Same" responses were allowed. No difference between the left-left and right-right composites was revealed but significant differences were obtained between "same" and the left-left or right-right. These results show that subjects detected asymmetry in beauty and suggest that very beautiful faces can be functionally asymmetrical. PMID:16040358

  6. Burns and beauty nails

    PubMed Central

    Bélanger, Richard E; Marcotte, Marie-Eve; Bégin, François

    2013-01-01

    A case involving a five-month-old girl brought to the emergency department with burns over her abdomen is described. The child was reported to have spilled two small bottles of beauty nail adhesive on her clothes while her mother was preparing dinner. After undressing the infant, the mother discovered several lesions on the child’s abdomen and quickly sought medical attention. Given the unusual circumstances of the presentation, the child was hospitalized for both treatment and supervision. The beauty nail adhesive contained cyanoacrylate. In addition to its well-appreciated adhesive capacity, cyanoacrylate, in the presence of cotton or other tissues, is known to produce an exothermic reaction that may cause burns. Cyanoacrylate-based products, due to their possible adverse effects, should be kept away from children as advised. Odd injuries should always raise concerns about the possibility of inflicted injury. PMID:24421671

  7. 2008 imaging beauty contest

    NASA Astrophysics Data System (ADS)

    Cotton, William; Monnier, John; Baron, Fabien; Hofmann, Karl-Heinz; Kraus, Stefan; Weigelt, Gerd; Rengaswamy, Sridharan; Thiébaut, Eric; Lawson, Peter; Jaffe, Walter; Hummel, Christian; Pauls, Tom; Schmitt, Henrique; Tuthill, Peter; Young, John

    2008-07-01

    We present the results of the third Optical/IR Interferometry Imaging Beauty Contest. A formal comparison is presented of the performance of algorithms used for imaging data from optical/infrared long-baseline interferometers. The contest consists of blind imaging of test data sets derived from model sources and distributed in the OI-FITS format. The test data consisted of datasets on two objects each "observed" in J, H, and K bands. The majority of the entries produced accurate reconstructions of the initial models. Each of the methods presented is discussed.

  8. Beauty Physics at CDF

    SciTech Connect

    Franco Bedeschi

    2001-09-04

    The CDF experiment has performed several measurements in the area of beauty and charm physics with the data collected during the Run I of the Tevatron. The experiment is now ready to collect new data at higher luminosity with a substantially improved detector. We discuss these improvements and the future measurements in this area of physics accessible after the first few years of data taking. These include the measurement of the mixing frequency of B{sub s} mesons and that of CP violation effects in the B{sub 0} sector.

  9. A Beautiful Story

    NASA Astrophysics Data System (ADS)

    García-Moliner, Federico

    In 1981, a time when our science administrators still believed that small is beautiful, I was sent to Cuba with a very simple mission: To establish contact with the solid state physicists at the University of Havana in order to identify affinities and prepare the ground for possible collaborations. I count this as one of the most fortunate events in my professional and human experience. It marked the beginning of a long lasting and very fruitful collaboration as well as of many brotherly friendships that have significantly contributed to the enrichment of my life as a human being.

  10. Beauty Culture I. Teachers Guide.

    ERIC Educational Resources Information Center

    Mankiw, Dorothy S.; Elefante, Michael A.

    This teacher's manual presents a course outline for the first semester (270 hours) of a four-semester course in beauty culture. The syllabus is divided into six sections and includes the following areas of instruction: shop, school, and the cosmetologist; sterilization practices in the beauty salon; scalp and hair applications and shampooing; hair…

  11. Is better beautiful or is beautiful better? Exploring the relationship between beauty and category structure.

    PubMed

    Sanders, Megan; Davis, Tyler; Love, Bradley C

    2013-06-01

    We evaluate two competing accounts of the relationship between beauty and category structure. According to the similarity-based view, beauty arises from category structure such that central items are favored due to their increased fluency. In contrast, the theory-based view holds that people's theories of beauty shape their perceptions of categories. In the present study, subjects learned to categorize abstract paintings into meaningfully labeled categories and rated the paintings' beauty, value, and typicality. Inconsistent with the similarity-based view, beauty ratings were highly correlated across conditions despite differences in fluency and assigned category structure. Consistent with the theory-based view, beautiful paintings were treated as central members for categories expected to contain beautiful paintings (e.g., art museum pieces), but not in others (e.g., student show pieces). These results suggest that the beauty of complex, real-world stimuli is not determined by fluency within category structure but, instead, interacts with people's prior knowledge to structure categories. PMID:23242799

  12. Engagement with beauty: appreciating natural, artistic, and moral beauty.

    PubMed

    Diessner, Rhett; Solom, Rebecca C; Frost, Nellie K; Parsons, Lucas; Davidson, John

    2008-05-01

    The Engagement With Beauty Scale (EBS), designed from the aesthetics of I. Kant (1790/1987), G. W. F. Hegel (ca. 1835/1993), and T. Aquinas (ca. 1260/1947) and the psychological work of J. Haidt (J. Haidt & D. Keltner, 2004), measures engagement with natural, artistic, and moral beauty. In Studies 1 and 2, the authors describe scale construction, exploratory factor analysis, confirmatory factor analysis, internal consistency, and temporal stability. In Studies 1 and 2, the authors also establish concurrent validity with the Appreciation of Beauty and Excellence subscale of the Values in Action Inventory of Strengths (C. Peterson & M. E. P. Seligman, 2004), the Gratitude, Resentment, and Appreciation Test (P. C. Watkins, K. Woodward, T. Stone, & R. L. Kolts, 2003), and the Spiritual Transcendence Scale (R. L. Piedmont, 2004). In Study 3, the authors used the EBS Artistic Beauty subscale to differentiate students engaged in the arts from those who were not. PMID:18589939

  13. Inner and outer beauty.

    PubMed

    Raymond, Kenneth N; Brown, Casey J

    2012-01-01

    Symmetry and pattern are precious forms of beauty that can be appreciated on both the macroscopic and molecular scales. Crystallographers have long appreciated the intimate connections between symmetry and molecular structure, reflected in their appreciation for the artwork of Escher. This admiration has been applied in the design of highly symmetrical coordination compounds. Two classes of materials are discussed: extended coordination arrays and discrete supramolecular assemblies. Extended coordination polymers have been implemented in gas separation and storage due to the remarkably porosity of these materials, aided by the ability to design ever-larger inner spaces within these frameworks. In the case of discrete symmetrical structures, defined inner and outer space present a unique aesthetic and chemical environment. The consequent host-guest chemistry and applications in catalysis are discussed. PMID:22076081

  14. Beauty Or Health? A Personal View.

    PubMed

    Riji, Haliza Mohd

    2006-01-01

    This paper deals with the question of beauty and health in women. It discusses changing definitions of beauty as a result of influences from the entertainment, beauty and health product industries. Advertisements are seen to be major players in defining beauty through promotion of cosmetic, skin, hair and slimming products. Concerns relating to beauty become inculcated in girls through the process of socialisation as they mature into womanhood. The media plays a significant role in portraying the meaning of beauty through its representation of women. These influences largely influence and alter women's perceptions of their body image and in trying to meet the goals of beauty as represented by the media. This may result in dissatisfaction with their body image. Advertisements can encourage women to indulge in smoking as a fashionable trend or opt for plastic surgery in attempts to acquire beauty. This paper concludes with implications of the issues relating to changing perceptions of beauty and suggests recommendations. PMID:26998213

  15. Sleeping Beauty Transposition.

    PubMed

    Ivics, Zoltán; Izsvák, Zsuzsanna

    2015-04-01

    Sleeping Beauty (SB) is a synthetic transposon that was constructed based on sequences of transpositionally inactive elements isolated from fish genomes. SB is a Tc1/mariner superfamily transposon following a cut-and-paste transpositional reaction, during which the element-encoded transposase interacts with its binding sites in the terminal inverted repeats of the transposon, promotes the assembly of a synaptic complex, catalyzes excision of the element out of its donor site, and integrates the excised transposon into a new location in target DNA. SB transposition is dependent on cellular host factors. Transcriptional control of transposase expression is regulated by the HMG2L1 transcription factor. Synaptic complex assembly is promoted by the HMGB1 protein and regulated by chromatin structure. SB transposition is highly dependent on the nonhomologous end joining (NHEJ) pathway of double-strand DNA break repair that generates a transposon footprint at the excision site. Through its association with the Miz-1 transcription factor, the SB transposase downregulates cyclin D1 expression that results in a slowdown of the cell-cycle in the G1 phase, where NHEJ is preferentially active. Transposon integration occurs at TA dinucleotides in the target DNA, which are duplicated at the flanks of the integrated transposon. SB shows a random genome-wide insertion profile in mammalian cells when launched from episomal vectors and "local hopping" when launched from chromosomal donor sites. Some of the excised transposons undergo a self-destructive autointegration reaction, which can partially explain why longer elements transpose less efficiently. SB became an important molecular tool for transgenesis, insertional mutagenesis, and gene therapy. PMID:26104705

  16. Performance of Pain, Performance of Beauty

    ERIC Educational Resources Information Center

    Thompson, James

    2006-01-01

    "Performance of pain, performance of beauty" explores performance projects in war zones using Elaine Scarry's definitions of "pain" and "beauty" as a starting point. The way in which pain constricts the body and the experience that beauty can take a person beyond the body become a contested framework for considering two examples of performance.…

  17. Beauty Products and the Consumer.

    ERIC Educational Resources Information Center

    New York State Education Dept., Albany. Bureau of Secondary Curriculum Development.

    GRADES OR AGES: High school. SUBJECT MATTER: Consumer education especially as it concerns the consumer's desire for beauty. Included are considerations of cosmetics, health spas, reducing salons, wigs, and jewelry. ORGANIZATION AND PHYSICAL APPEARANCE: The guide is discursively organized through the topics listed above. The physical appearance of…

  18. Beautiful Science: Worth a Visit

    ERIC Educational Resources Information Center

    Bingham, Frederick M.

    2013-01-01

    For those in the profession of teaching physics who reside in or plan to visit the Los Angeles area, I would highly recommend a trip to the Huntington Library in San Marino, specifically to a permanent exhibit entitled "Beautiful Science: Ideas that Changed the World" in the Dibner Hall of the History of Science. The exhibit contains original…

  19. Beauty Culture II. Teacher's Guide.

    ERIC Educational Resources Information Center

    Mankiw, Dorothy S.; Elefante, Michael A.

    This teacher's manual presents a course outline for the second semester (270 hours) of a four-semester course in beauty culture. The syllabus is divided into nine sections and includes the following areas of instruction: the shop and the cosmetologist; scalp applications and shampooing; hair styling; hair cutting; manicuring and pedicuring;…

  20. The beauty and the beast inside: the american beauty--does cosmetic surgery help?

    PubMed

    Lijtmaer, Ruth

    2010-01-01

    American society's feminine ideal has consistently emphasized youth as beauty and getting old as ugly. Feeling unattractive produces several intrapsychic conflicts leading to depression and anxiety. Summary of the literature on beauty and aging, beauty and culture, and theories of physical beauty will be presented. With a clinical example of a female patient, the writer investigates the conscious and unconscious fantasies, conflicts, and sense of self inside and outside that impelled a physically beautiful female patient to bring her own body closer to her perception of idealized beauty with the aid of plastic surgery. PMID:20528134

  1. Is moral beauty different from facial beauty? Evidence from an fMRI study

    PubMed Central

    Wang, Tingting; Mo, Ce; Tan, Li Hai; Cant, Jonathan S.; Zhong, Luojin; Cupchik, Gerald

    2015-01-01

    Is moral beauty different from facial beauty? Two functional magnetic resonance imaging experiments were performed to answer this question. Experiment 1 investigated the network of moral aesthetic judgments and facial aesthetic judgments. Participants performed aesthetic judgments and gender judgments on both faces and scenes containing moral acts. The conjunction analysis of the contrasts ‘facial aesthetic judgment > facial gender judgment’ and ‘scene moral aesthetic judgment > scene gender judgment’ identified the common involvement of the orbitofrontal cortex (OFC), inferior temporal gyrus and medial superior frontal gyrus, suggesting that both types of aesthetic judgments are based on the orchestration of perceptual, emotional and cognitive components. Experiment 2 examined the network of facial beauty and moral beauty during implicit perception. Participants performed a non-aesthetic judgment task on both faces (beautiful vs common) and scenes (containing morally beautiful vs neutral information). We observed that facial beauty (beautiful faces > common faces) involved both the cortical reward region OFC and the subcortical reward region putamen, whereas moral beauty (moral beauty scenes > moral neutral scenes) only involved the OFC. Moreover, compared with facial beauty, moral beauty spanned a larger-scale cortical network, indicating more advanced and complex cerebral representations characterizing moral beauty. PMID:25298010

  2. Is moral beauty different from facial beauty? Evidence from an fMRI study.

    PubMed

    Wang, Tingting; Mo, Lei; Mo, Ce; Tan, Li Hai; Cant, Jonathan S; Zhong, Luojin; Cupchik, Gerald

    2015-06-01

    Is moral beauty different from facial beauty? Two functional magnetic resonance imaging experiments were performed to answer this question. Experiment 1 investigated the network of moral aesthetic judgments and facial aesthetic judgments. Participants performed aesthetic judgments and gender judgments on both faces and scenes containing moral acts. The conjunction analysis of the contrasts 'facial aesthetic judgment > facial gender judgment' and 'scene moral aesthetic judgment > scene gender judgment' identified the common involvement of the orbitofrontal cortex (OFC), inferior temporal gyrus and medial superior frontal gyrus, suggesting that both types of aesthetic judgments are based on the orchestration of perceptual, emotional and cognitive components. Experiment 2 examined the network of facial beauty and moral beauty during implicit perception. Participants performed a non-aesthetic judgment task on both faces (beautiful vs common) and scenes (containing morally beautiful vs neutral information). We observed that facial beauty (beautiful faces > common faces) involved both the cortical reward region OFC and the subcortical reward region putamen, whereas moral beauty (moral beauty scenes > moral neutral scenes) only involved the OFC. Moreover, compared with facial beauty, moral beauty spanned a larger-scale cortical network, indicating more advanced and complex cerebral representations characterizing moral beauty. PMID:25298010

  3. Ugly Risks of Beauty Routines.

    PubMed

    Kloser

    1996-12-01

    Beauty products and practices may put women at risk for infection. Adverse events range in seriousness from the superficial to the systemic--from conjunctivitis caused by contaminated eye makeup, to fungal infections picked up from the locker room or manicurist, to more troubling soft-tissue infections caused by unsanitary body piercing or tattooing, practices that can also transmit hepatitis B and C. PMID:9746661

  4. Light detectors for beauty physics

    NASA Astrophysics Data System (ADS)

    DeSalvo, R.

    1996-12-01

    Cherenkov light is used to identify beauty mesons in high energy interactions in an increasing number of experiments. Speed and pixel dimension requirements are generating a revival of the vacuum light detectors as the active component of Cherenkov light detectors in the new high luminosity and high background experiments. The insensitivity to magnetic fields of the most modern vacuum light detectors also helps making these devices more competitive.

  5. Perceiving beauty in all women: Psychometric evaluation of the Broad Conceptualization of Beauty Scale.

    PubMed

    Tylka, Tracy L; Iannantuono, Amy C

    2016-06-01

    Women's ability to broadly conceptualize beauty (i.e., perceive many looks, appearances, body sizes/shapes, and inner characteristics as beautiful) has been identified as a facet of positive body image in qualitative research. A scale is needed to be able to assess this construct within quantitative research. Therefore, we developed the Broad Conceptualization of Beauty Scale (BCBS), which measures the extent women define female beauty widely within external and internal characteristics, and examined its psychometric properties among four community samples totaling 1086 women. Exploratory and confirmatory factor analyses revealed a unidimensional structure with nine items. The internal consistency, test-retest reliability, and construct (convergent, discriminant, and incremental) validity of its scores were upheld. Researchers and clinicians can use the BCBS alone to assess women's perceptions of female beauty, or they can use the BCBS alongside women's perceptions of self-beauty to more comprehensively explore women's ability to broadly conceptualize beauty for others and themselves. PMID:26971117

  6. Beautiful Science: Worth a Visit

    NASA Astrophysics Data System (ADS)

    Bingham, Frederick M.

    2013-03-01

    For those in the profession of teaching physics who reside in or plan to visit the Los Angeles area, I would highly recommend a trip to the Huntington Library in San Marino, specifically to a permanent exhibit entitled "Beautiful Science: Ideas that Changed the World" in the Dibner Hall of the History of Science. The exhibit contains original books and manuscripts from the library's own collections. The sheer magnitude of human achievement represented here and the amount of effort and money that must have been required to amass these books boggles the mind.

  7. Is Beauty an Archaic Spirit in Education?

    ERIC Educational Resources Information Center

    Cannatella, Howard

    2006-01-01

    This article discusses the unfashionable and taboo idea that beauty matters. The author's supposition is that beauty as a poetic force should be regarded as one of the defining characteristics central to pedagogic practice. In making this claim he draws upon a few of Charles Dickens' and William Wordsworth's ideas in support of the importance of…

  8. Surrounded by Beauty: Arts of Native America.

    ERIC Educational Resources Information Center

    2002

    Native American languages have no equivalent for the word "art." Yet the objects Native Americans have used and still use suggest that they are a highly spiritual people who create objects of extraordinary beauty. In Native American thought, there is no distinction between what is beautiful or functional, and what is sacred or secular. Design goes…

  9. Charm and beauty physics at Fermilab

    SciTech Connect

    Lipton, R.

    1992-01-01

    The status of charm and beauty physics studies at Fermilab is reviewed. Data from fixed target experiments on charm production, semi-leptonic decay, and Cabibbo suppressed decays as well as charmonium studies in antiproton annihilation are described. In addition beauty results from CDF and E653 are reviewed and prospects for studies of B physics at collider detectors are discussed.

  10. Bathing in Reeking Wounds: The Liberal Arts, Beauty, and War

    ERIC Educational Resources Information Center

    Stimpson, Catharine R.

    2014-01-01

    A historic dialectic exists between the beautiful and the bestial. The bestial destroys the beautiful, but in a bloody miracle, the beautiful emerges from the womb of the bestial, the "terrible beauty" of which the poet W. B. Yeats wrote. The liberal arts, so often thought to dwell in a remote ivory tower, embody this dialectic. Wars and…

  11. Changing perceptions of beauty: a surgeon's perspective.

    PubMed

    Adamson, Peter A; Zavod, Matthew B

    2006-08-01

    Beauty is a mystery that has been with us for ages. Scholars and scientists have investigated its roots and effects, and its presence is ubiquitous. Has the construct of beauty changed over time? Is our sense of beauty learned or innate? What IS beauty, and can we quantify it? A substantial amount of work supports a Darwinian theory of selection, which predicts a survival advantage based on physical attractiveness. However, there is evidence that certain perceptions of beauty change with time. Indeed, the recent globalization of modern society has wrought changes in our perceptions of beauty. Are patients electing cosmetic surgery procuring a survival advantage, or are they bypassing genetics and setting a new standard for beauty? As facial plastic surgeons, we must be poised to respond to this metamorphosis and understand its roots. Although there is some equivocation and debate about this elusive subject, it is our duty to stay abreast of the current dynamic to make sound judgments that are in the best interests of our patients. PMID:17048159

  12. Beauty and cuteness in peripheral vision

    PubMed Central

    Kuraguchi, Kana; Ashida, Hiroshi

    2015-01-01

    Guo et al. (2011) showed that attractiveness was detectable in peripheral vision. Since there are different types of attractiveness (Rhodes, 2006), we investigated how beauty and cuteness are detected in peripheral vision with a brief presentation. Participants (n = 45) observed two Japanese female faces for 100 ms, then were asked to respond which face was more beautiful (or cuter). The results indicated that both beauty and cuteness were detectable in peripheral vision, but not in the same manner. Discrimination rates for judging beauty were invariant in peripheral and central vision, while discrimination rates for judging cuteness declined in peripheral vision as compared with central vision. This was not explained by lower resolution in peripheral vision. In addition, for male participants, it was more difficult to judge cuteness than beauty in peripheral vision, thus suggesting that gender differences can have a certain effect when judging cuteness. Therefore, central vision might be suitable for judging cuteness while judging beauty might not be affected by either central or peripheral vision. This might be related with the functional difference between beauty and cuteness. PMID:25999883

  13. Charm and Beauty in Photoproduction at HERA

    NASA Astrophysics Data System (ADS)

    Dobre, Monica

    2014-04-01

    The photoproduction of beauty and charm quarks at the ep collider HERA are presented. The b-quarks production was investigated in the bb → eeX' channel and the differential production cross section was measured as a function of the average transverse momentum of the beauty quarks down to the threshold. The cross section of D* meson decaying in the golden channel was determined both inclusively and in D*-tagged dijet events. Exploiting the characteristics of the heavy-flavoured hadron decays, beauty and charm quark cross sections were also measured in dijet events using secondary vertices or semi-muonic decays.

  14. Neuroaesthetics and the trouble with beauty.

    PubMed

    Conway, Bevil R; Rehding, Alexander

    2013-01-01

    Neuroscience is increasingly being called upon to address issues within the humanities. We discuss challenges that arise, relating to art and beauty, and provide ideas for a way forward. PMID:23526878

  15. Charm, beauty and top at HERA

    NASA Astrophysics Data System (ADS)

    Behnke, O.; Geiser, A.; Lisovyi, M.

    2015-09-01

    Results on open charm and beauty production and on the search for top production in high-energy electron-proton collisions at HERA are reviewed. This includes a discussion of relevant theoretical aspects, a summary of the available measurements and measurement techniques, and their impact on improved understanding of QCD and its parameters, such as parton density functions and charm- and beauty-quark masses. The impact of these results on measurements at the LHC and elsewhere is also addressed.

  16. The possibility to measure the magnetic moments of short-lived particles (charm and beauty baryons) at LHC and FCC energies using the phenomenon of spin rotation in crystals

    NASA Astrophysics Data System (ADS)

    Baryshevsky, V. G.

    2016-06-01

    The use of spin rotation effect in bent crystals for measuring the magnetic moment of short-lived particles in the range of LHC and FCC energies is considered. It is shown that the estimated number of produced baryons that are captured into a bent crystal grows as ∼γ 3 / 2 with increasing particle energy. Hence it may be concluded that the experimental measurement of magnetic moments of short-lived particles using the spin rotation effect is feasible at LHC and higher energies (for LHC energies, e.g., the running time required for measuring the magnetic moment of Λc+is 2 ÷ 16 hours).

  17. The possibility to measure the magnetic moments of short-lived particles (charm and beauty baryons) at LHC and FCC energies using the phenomenon of spin rotation in crystals

    NASA Astrophysics Data System (ADS)

    Baryshevsky, V. G.

    2016-06-01

    The use of spin rotation effect in bent crystals for measuring the magnetic moment of short-lived particles in the range of LHC and FCC energies is considered. It is shown that the estimated number of produced baryons that are captured into a bent crystal grows as ∼γ 3 / 2 with increasing particle energy. Hence it may be concluded that the experimental measurement of magnetic moments of short-lived particles using the spin rotation effect is feasible at LHC and higher energies (for LHC energies, e.g., the running time required for measuring the magnetic moment of Λc+ is 2 ÷ 16 hours).

  18. The Ten Most Beautiful Experiments

    SciTech Connect

    Johnson, George

    2010-10-20

    "Science in the 21st century has become industrialized. The experiments so often celebrated in the newspapers - sequencing the genome, proving the existence of the top quark, discovering a new planet by analyzing the wobble of a distant start - cost millions of dollars. They generate terabytes of data to be analyzed by supercomputers, calculating factories that spew out so much heat that they are equipped with cooling stacks and consume the energy of a small town. The experiments are carried out by research teams that have grown to the size of small corporations. But until very recently the most earth-shaking science came from individual pairs of hands. From a single mind confronting the unknown. The great experiments that mark the edges of our understanding were most often performed by one or two scientists and usually on a tabletop. Computation, if there was any, was carried out on paper or later with a slide rule. These experiments were designed and conducted with such straightforward elegance that they deserve to be called beautiful." (excerpt from the slide presentation accompanying the video)

  19. 7 CFR 650.24 - Scenic beauty (visual resource).

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Scenic beauty (visual resource). (a) Background. Contributions to scenic beauty are a normal product of... while reducing the potential for erosion; using native and other adaptable plants for conservation...

  20. The evolutionary psychology of facial beauty.

    PubMed

    Rhodes, Gillian

    2006-01-01

    What makes a face attractive and why do we have the preferences we do? Emergence of preferences early in development and cross-cultural agreement on attractiveness challenge a long-held view that our preferences reflect arbitrary standards of beauty set by cultures. Averageness, symmetry, and sexual dimorphism are good candidates for biologically based standards of beauty. A critical review and meta-analyses indicate that all three are attractive in both male and female faces and across cultures. Theorists have proposed that face preferences may be adaptations for mate choice because attractive traits signal important aspects of mate quality, such as health. Others have argued that they may simply be by-products of the way brains process information. Although often presented as alternatives, I argue that both kinds of selection pressures may have shaped our perceptions of facial beauty. PMID:16318594

  1. 75 FR 21595 - Beauty and Cosmetics Trade Mission to India

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... International Trade Administration Beauty and Cosmetics Trade Mission to India AGENCY: International Trade... Beauty and Cosmetics Trade Mission to India (New Delhi, Mumbai and Bangalore), November 15-19, 2010. Led... Indian market. The cosmetics/ beauty industry is one of the booming retail sectors in India with...

  2. 75 FR 33763 - Beauty and Cosmetics Trade Mission to India

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-15

    ... International Trade Administration Beauty and Cosmetics Trade Mission to India AGENCY: International Trade... Beauty and Cosmetics Trade Mission to India (New Delhi, Mumbai and Bangalore), November 15-19, 2010. Led.... The cosmetics/beauty industry is one of the booming retail sectors in India with very strong...

  3. Walking in Beauty: An American Indian Perspective on Social Justice

    ERIC Educational Resources Information Center

    Eason, Evan Allen; Robbins, Rockey

    2012-01-01

    The purpose of this article is to introduce "walking in beauty," an American Indian spiritual perspective related to social justice that emphasizes beauty, harmony, connectedness/unity of experience, and imagination. Walking in beauty includes 3 processes: embodiment, creativity, and appreciation of the sublime. Recommendations are offered for…

  4. Explosions in Majestic Spiral Beauties

    NASA Astrophysics Data System (ADS)

    2004-12-01

    Images of beautiful galaxies, and in particular of spiral brethren of our own Milky Way, leaves no-one unmoved. It is difficult indeed to resist the charm of these impressive grand structures. Astronomers at Paranal Observatory used the versatile VIMOS instrument on the Very Large Telescope to photograph two magnificent examples of such "island universes", both of which are seen in a southern constellation with an animal name. But more significantly, both galaxies harboured a particular type of supernova, the explosion of a massive star during a late and fatal evolutionary stage. The first image (PR Photo 33a/04) is of the impressive spiral galaxy NGC 6118 [1], located near the celestial equator, in the constellation Serpens (The Snake). It is a comparatively faint object of 13th magnitude with a rather low surface brightness, making it pretty hard to see in small telescopes. This shyness has prompted amateur astronomers to nickname NGC 6118 the "Blinking Galaxy" as it would appear to flick into existence when viewed through their telescopes in a certain orientation, and then suddenly disappear again as the eye position shifted. There is of course no such problem for the VLT's enormous light-collecting power and ability to produce sharp images, and this magnificent galaxy is here seen in unequalled detail. The colour photo is based on a series of exposures behind different optical filters, obtained with the VIMOS multi-mode instrument on the 8.2-m VLT Melipal telescope during several nights around August 21, 2004. About 80 million light-years away, NGC 6118 is a grand-design spiral seen at an angle, with a very small central bar and several rather tightly wound spiral arms (it is classified as of type "SA(s)cd" [2]) in which large numbers of bright bluish knots are visible. Most of them are active star-forming regions and in some, very luminous and young stars can be perceived. Of particular interest is the comparatively bright stellar-like object situated directly

  5. Beauty meson decays to charmonium

    NASA Astrophysics Data System (ADS)

    Ershov, Alexey Valerievich

    2001-10-01

    We study decays of beauty (B) mesons into the final states containing charmonium mesons. The data were collected by the CLEO experiment at the Cornell Electron Storage Ring from 1990 to 1999. First, we describe a technique that significantly improves the reconstruction efficiency for decays of J/ y and y (2S) mesons into a pair of leptons. This reconstruction method is used in all the analyses presented in this dissertation. Then we present a study of B decays to the χc 1 and χc2 charmonium states and compare our results with the predictions of different theoretical models of charmonium production. After that we report the first observation of the decay B --> J/ y φK, which is the first B meson decay requiring a creation of an additional ss¯ quark pair. Then we measure the B0 and B+ meson masses from B0 --> y (') K0S and B+ --> y (') K+ decays. The method employed eliminates the dominant systematic uncertainty associated with the previous B meson mass measurements at the e+e- colliders and results in a significant improvement in precision. After that we present a study of three B0 decay modes useful for time-dependent CP asymmetry measurements. In this study we reconstruct B0 --> J/ y K0S , B0 --> χc 1 K0S , and B0 --> J/ y π0 decays. The latter two decay modes are observed for the first time. We describe a K0S --> π0π0 detection technique and its application to the reconstruction of the decay B 0 --> J/ y K0S . Then we present a sensitivity study for the measurement of the mixing-induced CP violation in the neutral B meson system (parameter sin 2β) at CLEO using the method that requires a measurement of the decay time of only one meson in a B0overline B0 pair. Finally, we search for direct CP violation in decays B+/- --> J/ y K+/- and B +/- --> y (2S) K+/- . The results of this search are consistent with the Standard Model expectations and provide the first experimental test of the assumption that direct CP violation is negligible in B --> y (') K decays.

  6. The Particle Hunters

    NASA Astrophysics Data System (ADS)

    Ne'eman, Yuval; Kirsh, Yoram

    1996-04-01

    Preface to the first edition; Preface to the second edition; 1. The building blocks of the atom; 2. Physical laws for small particles; 3. The discoveries of the 1930s and 1940s; 4. Particle accelerators - or from hunters to farmers; 5. Strange particles; 6. Basic forces and the classification of particles; 7. Conservation laws; 8. Short-lived particles; 9. To the quarks - via the eightfold way; 10. More quarks - or charm, truth and beauty; 11. The standard model and beyond; Appendix 1. Properties of semi-stable particles; Appendix 2. The Greek alphabet; Name index; Subject index.

  7. Beauty baryon decays: a theoretical overview

    NASA Astrophysics Data System (ADS)

    Wang, Yu-Ming

    2014-11-01

    I overview the theoretical status and recent progress on the calculations of beauty baryon decays focusing on the QCD aspects of the exclusive semi-leptonic Λb → plμ decay at large recoil and theoretical challenges of radiative and electro-weak penguin decays Λb → Λγ,Λl+l-.

  8. Mathematicians in Schools: Uncovering Maths' Beautiful Secrets

    ERIC Educational Resources Information Center

    Welch, Bronwyn

    2016-01-01

    Mathematics professionals are working with teachers revealing the reality and beauty that happens in the world of math and to show that this is essentially a "human endeavour," embedded in much of what people do and the ways in which they think. In this article, the author shares vignettes of primary classes working with mathematicians…

  9. Beauty as Fit: A Metaphor in Mathematics?

    ERIC Educational Resources Information Center

    Raman, Manya; Öhman, Lars-Daniel

    2013-01-01

    Beauty, which plays a central role in the practice of mathematics (Sinclair 2002), is almost absent in discussions of school mathematics (Dreyfus and Eisenberg 1986). This is problematic, because students will decide whether or not to continue their studies in mathematics without having an accurate picture of what the subject is about. In order to…

  10. Bountiful health care and A Beautiful Mind.

    PubMed

    Flower, Joe

    2002-01-01

    The Nash Equilibrium (put forward by John Nash and celebrated in the film, A Beautiful Mind) mathematically describes multi-player, infinite games. It is a general description of large human transactions, such as health care. Learn how new inputs, new players or new resources can disrupt these transactions. PMID:12219533

  11. Why Beautiful People Are More Intelligent

    ERIC Educational Resources Information Center

    Kanazawa, Satoshi; Kovar, Jody L.

    2004-01-01

    Empirical studies demonstrate that individuals perceive physically attractive others to be more intelligent than physically unattractive others. While most researchers dismiss this perception as a ''bias'' or ''stereotype,'' we contend that individuals have this perception because beautiful people indeed "are" more intelligent. The conclusion that…

  12. Natural Tendency towards Beauty in Humans: Evidence from Binocular Rivalry

    PubMed Central

    Mo, Lei

    2016-01-01

    Although human preference for beauty is common and compelling in daily life, it remains unknown whether such preference is essentially subserved by social cognitive demands or natural tendency towards beauty encoded in the human mind intrinsically. Here we demonstrate experimentally that humans automatically exhibit preference for visual and moral beauty without explicit cognitive efforts. Using a binocular rivalry paradigm, we identified enhanced gender-independent perceptual dominance for physically attractive persons, and the results suggested universal preference for visual beauty based on perceivable forms. Moreover, we also identified perceptual dominance enhancement for characters associated with virtuous descriptions after controlling for facial attractiveness and vigilance-related attention effects, which suggested a similar implicit preference for moral beauty conveyed in prosocial behaviours. Our findings show that behavioural preference for beauty is driven by an inherent natural tendency towards beauty in humans rather than explicit social cognitive processes. PMID:26930202

  13. Natural Tendency towards Beauty in Humans: Evidence from Binocular Rivalry.

    PubMed

    Mo, Ce; Xia, Tiansheng; Qin, Kaixin; Mo, Lei

    2016-01-01

    Although human preference for beauty is common and compelling in daily life, it remains unknown whether such preference is essentially subserved by social cognitive demands or natural tendency towards beauty encoded in the human mind intrinsically. Here we demonstrate experimentally that humans automatically exhibit preference for visual and moral beauty without explicit cognitive efforts. Using a binocular rivalry paradigm, we identified enhanced gender-independent perceptual dominance for physically attractive persons, and the results suggested universal preference for visual beauty based on perceivable forms. Moreover, we also identified perceptual dominance enhancement for characters associated with virtuous descriptions after controlling for facial attractiveness and vigilance-related attention effects, which suggested a similar implicit preference for moral beauty conveyed in prosocial behaviours. Our findings show that behavioural preference for beauty is driven by an inherent natural tendency towards beauty in humans rather than explicit social cognitive processes. PMID:26930202

  14. Small is beautiful: Surprising nanoparticles.

    PubMed

    Duchêne, Dominique; Gref, Ruxandra

    2016-04-11

    In the preparation of nanoparticles for drug delivery, it is well known that their size as well as their surface decorations can play a major role in interaction with living media. It is less known that their shape and internal structure can interplay with cellular and in vivo fate. The scientific literature is full of a large variety of surprising terms referring to their shape and structure. The aim of this review is to present some examples of the most often encountered surprising nanoparticles prepared and usable in the pharmaceutical technology domain. They are presented in two main groups related to their physical aspects: 1) smooth surface particles, such as Janus particles, "snowmen", "dumbbells", "rattles", and "onions" and 2) branched particles, such as "flowers", "stars" and "urchins". The mode of preparation and potential applications are briefly presented. The topic has a serious, wider importance, namely in opportunity these structures have to allow exploration of the role of shape and structure on the utility (and perhaps toxicity) of these nanostructures. PMID:26902723

  15. The Hidden Beauty in Biomedical Imaging.

    PubMed

    Barker, Norman; Iacobuzio-Donahue, Christine

    2015-01-01

    Caretakers, researchers and photographers working in a busy academic settings, every day are faced with images that are awe-inspiring for their beauty and for the terror they may represent to patients suffering from disease. Beauty in this context is a relative term. It may be seen as the delicate lacework of cells within the normal human brain reminiscent of a Jackson Pollack masterpiece, or the multitude of colors and textures formed by fungal organisms in a microbiology lab. Herein lies the juxtaposition image makers seek to represent. When contemplated in isolation, each represents a visually interesting image. However, when viewed with an awareness of the context in which the image was obtained, each image takes on the ability to evoke an alternative human emotion. PMID:26828553

  16. ''Beauty of Wholeness and Beauty of Partiality.'' New Terms Defining the Concept of Beauty in Architecture in Terms of Sustainability and Computer Aided Design

    ERIC Educational Resources Information Center

    Farid, Ayman A.; Zaghloul, Weaam M.; Dewidar, Khaled M.

    2014-01-01

    The great shift in sustainability and computer aided design in the field of architecture caused a remarkable change in the architecture philosophy, new aspects of beauty and aesthetic values are being introduced, and traditional definitions for beauty cannot fully cover this aspects, which causes a gap between; new architecture works criticism and…

  17. The 2014 interferometric imaging beauty contest

    NASA Astrophysics Data System (ADS)

    Monnier, John D.; Berger, Jean-Philippe; Le Bouquin, Jean-Baptiste; Tuthill, Peter G.; Wittkowski, Markus; Grellmann, Rebekka; Müller, André; Renganswany, Sridhar; Hummel, Christian; Hofmann, Karl-Heinz; Schertl, Dieter; Weigelt, Gerd; Young, John; Buscher, David; Sanchez-Bermudez, Joel; Alberdi, Antxon; Schoedel, Rainer; Köhler, Rainer; Soulez, Ferréol; Thiébaut, Éric; Kluska, Jacques; Malbet, Fabien; Duvert, Gilles; Kraus, Stefan; Kloppenborg, Brian K.; Baron, Fabien; de Wit, Willem-Jan; Rivinius, Thomas; Merand, Antoine

    2014-07-01

    Here we present the results of the 6th biennial optical interferometry imaging beauty contest. Taking advantage of a unique opportunity, the red supergiant VY CMa and the Mira variable R Car were observed in the astronomical H-band with three 4-telescope configurations of the VLTI-AT array using the PIONIER instrument. The community was invited to participate in the subsequent image reconstruction and interpretation phases of the project. Ten groups submitted entries to the beauty contest, and we found reasonable consistency between images obtained from independent workers using quite different algorithms. We also found that significant differences existed between the submitted images, much greater than in past beauty contests that were all based on simulated data. A novel crowd-sourcing" method allowed consensus median images to be constructed, filtering likely artifacts and retaining real features." We definitively detect strong spots on the surfaces of both stars as well as distinct circumstellar shells of emission (likely water/CO) around R Car. In a close contest, Joel Sanchez (IAA-CSIC/Spain) was named the winner of the 2014 interferometric imaging beauty contest. This process has shown that new comers" can use publicly-available imaging software to interpret VLTI/PIONIER imaging data, as long as sufficient observations are taken to have complete uv coverage { a luxury that is often missing. We urge proposers to request adequate observing nights to collect sufficient data for imaging and for time allocation committees to recognise the importance of uv coverage for reliable interpretation of interferometric data. We believe that the result of the proposed broad international project will contribute to inspiring trust in the image reconstruction processes in optical interferometry.

  18. Fibonacci, quasicrystals and the beauty of flowers

    PubMed Central

    Gardiner, John

    2012-01-01

    The appearance of Fibonacci sequences and the golden ratio in plant structures is one of the great outstanding puzzles of biology. Here I suggest that quasicrystals, which naturally pack in the golden ratio, may be ubiquitous in biological systems and introduce the golden ratio into plant phyllotaxy. The appearance of golden ratio-based structures as beautiful indicates that the golden ratio may play a role in the development of consciousness and lead to the aesthetic natural selection of flowering plants. PMID:23072998

  19. Lifetimes of charm and beauty hadrons

    NASA Astrophysics Data System (ADS)

    Bellini, G.; Bigi, I. I.; Dornan, P. J.

    1997-10-01

    Major breakthroughs have been achieved in the determination of the lifetimes of charm and beauty hadrons. Much larger data samples than previously have become available and new experimental devices and techniques have been developed and employed. The lifetimes of all weakly decaying singly charmed hadrons have been measured, some with an accuracy of a few percent. The difference in the shortest lifetime - τ(Ω c) - and the longest one - τ( D+) - is given by a factor of close to ten. The experimental status of beauty lifetimes, while less complete, has still reached a new level of quality and is now better than 5% for the commoner states. New theoretical tools, based mainly on heavy quark expansions, have been developed; they incorporate as well as transcend earlier phenomenological descriptions. The observed pattern in the charm lifetime ratios is reproduced in a semi-quantitative manner as well as could be expected; as far as the beauty lifetime ratios are concerned some problems may well be emerging. The maturity level achieved in the measurements bodes quite well for future challenges where reliable and efficient tracking of the decay vertices will be crucial.

  20. Beauty in abstract paintings: perceptual contrast and statistical properties

    PubMed Central

    Mallon, Birgit; Redies, Christoph; Hayn-Leichsenring, Gregor U.

    2014-01-01

    In this study, we combined the behavioral and objective approach in the field of empirical aesthetics. First, we studied the perception of beauty by investigating shifts in evaluation on perceived beauty of abstract artworks (Experiment 1). Because the participants showed heterogeneous individual preferences for the paintings, we divided them into seven clusters for the test. The experiment revealed a clear pattern of perceptual contrast. The perceived beauty of abstract paintings increased after exposure to paintings that were rated as less beautiful, and it decreased after exposure to paintings that were rated as more beautiful. Next, we searched for correlations of beauty ratings and perceptual contrast with statistical properties of abstract artworks (Experiment 2). The participants showed significant preferences for particular image properties. These preferences differed between the clusters of participants. Strikingly, next to color measures like hue, saturation, value and lightness, the recently described Pyramid of Histograms of Orientation Gradients (PHOG) self-similarity value seems to be a predictor for aesthetic appreciation of abstract artworks. We speculate that the shift in evaluation in Experiment 1 was, at least in part, based on low-level adaptation to some of the statistical image properties analyzed in Experiment 2. In conclusion, our findings demonstrate that the perception of beauty in abstract artworks is altered after exposure to beautiful or non-beautiful images and correlates with particular image properties, especially color measures and self-similarity. PMID:24711791

  1. [Beauty judgment: review of the literature].

    PubMed

    Faure, Jacques; Bolender, Yves

    2014-03-01

    Esthetic judgments are surely subjective, but as surely, that does not preclude them being studied objectively through rigorous scientific methods. The factual basis of a science of esthetics is not to settle whether some person or image is "objectively beautiful" but rather to determine whether some representative set or sets of individuals judge or experience him/her/it as beautiful or unattractive. The aim of this paper is to review the definitional, theoretical and methodological aspects pertaining to the perception of facial/dental attractiveness by a group of representative individuals. The first part lays down the basic principles of the perception of facial/dental attractiveness: the perception involves a jury, a field of investigation and a test providing quantitative data; the following general determinants of beauty perception are reviewed: the average morphology, the judge's cultural background, the numerology, the judge's ethnical origin. Indirect determinants are the dentition, the osseous architecture and the muscular envelope. Some disruptive factors might alter the judges' facial perception. They might be qualified as either peripheral to the face or psycho-social factors. Peripheral factors include hair style and color, skin hue, wrinkles, lips color... Psycho-social factors cover the personality of the subject being evaluated, his/her intelligence or behavior. The second part deals specifically with the methodology used to determine facial attractiveness and to correlate this latter with a specific morphology. Typically such a study aims to determine average esthetic preferences for some set of visual displays among a particular jury, given a specific task to judge esthetic quality or qualities. The sample being studied, the displays, the jury or jurys, the rating procedure must all be specified prior to collecting data. A specific emphasis will be given to the rating process and the associated morphometrics, the ultimate goal being to

  2. Haiti. Beauty parlours and health promoters.

    PubMed

    Hughes, H

    1990-04-01

    In the poor neighborhoods of the capital city of Port au Prince Haiti are 100s of brightly painted beauty parlors, displaying signs like "Femme Moderne, studio de beaute." They are popular and cheap; between 70 and 80% of the population use them. In the south of the city, a team of health promotion volunteers are turning some 64 beauty parlors into AIDS education and condom distribution centers with the help and cooperation of the owners. The majority of these beauty parlors are owned and run by women who cannot find work elsewhere, including many immigrants from the Dominican Republic. Some proprietors work as prostitutes in the evenings because they cannot survive on the earnings of the parlors. These proprietors are now becoming AIDS educators-- talking to customers, handing out leaflets and distributing free condoms. The team of young volunteers responsible for this education program belong to the Center for Haitian Social Services (CHASS); a nonprofit, voluntary organization set up in 1987 as a community response to the lack of government health and social services. A CHASS volunteer explains: "The beauty parlors were chosen as a focal point for reaching the population. To start with, 1 box of condoms was distributed every week, not the owners are distributing 3 or 4 boxes. We encourage them to keep a record of numbers taken, client's age, sex, marital status and so on." The majority of volunteer health promoters are ex-students who have given up their studies because of lack of funds. Many cannot find jobs, and they are encouraged to develop skills in their volunteer work which could help them find employment in the future. The team of volunteers meets every Saturday to discuss the program and training needs that arise. "At first the focus of our training was on AIDS, but now we need more information about other related issues." The most urgent need is to find out what local people's thoughts and understandings are about the disease. CHASS has designed a

  3. Cosmeceuticals: the new medicine of beauty.

    PubMed

    Martin, Katherine I; Glaser, Dee Anna

    2011-01-01

    Cosmeceuticals represent a new category of products placed between cosmetics and pharmaceuticals that are intended for the enhancement of both the health and beauty of skin. Encompassing an ever-increasing part of the skin care industry, cosmeceuticals are formulated from a multitude of ingredients, the main categories of which are discussed in this article. Given the growing interest in these products among patients and the strong claims made by manufacturers, it is important that physicians recognize these agents and understand their benefits, limitations, and potential adverse effects. PMID:21462614

  4. Charm and beauty production at CDF

    SciTech Connect

    Bishai, M.; /Brookhaven

    2005-01-01

    Using the data samples collected with the CDF Run II detector during 2002 and early 2003, new measurements of the production cross sections of charm and beauty hadrons at {radical}s = 1960 GeV are presented. New measurements of the cross sections of centrally produced b-hadrons and J/{psi} mesons down to zero transverse momenta have been carried out. The large charm signals made available by the silicon vertex track trigger have enabled the measurement of the cross sections of D{sup 0}, D*, D{sup {+-}}, and D{sub s} mesons.

  5. Beauty Baryons at CDF and DO

    SciTech Connect

    Kryemadhi, Abaz

    2006-11-17

    The results from Tevatron in the baryonic sector are presented. The lifetime of {lambda}b {yields} J/{psi}{lambda}, the observation of hadronic decay of {lambda}b {yields} {lambda}c{pi}, the semileptonic decays of {lambda}b {yields} {lambda}c{mu}{nu}, the hadronization of the b-baryons, and the {lambda}b decays to {lambda}b {yields} p{pi} and {lambda}b {yields} pK are discussed. These measurements paint a nice picture of our understanding of the beauty baryons.

  6. Beauty: A Concept with Practical Implications for Teacher Researchers

    ERIC Educational Resources Information Center

    Winston, Joe

    2011-01-01

    Hillman's (2001) simple affirmation that "an idea of beauty is useful, functional, practical" is one this article attempts to pursue with teacher researchers in mind, based on the belief that to move from the "re"pression of beauty to its "ex"pression--or, at the very least, to its articulation--will enlighten rather than distract individuals. The…

  7. Preschoolers' Ideas of What Makes a Picture Book Illustration Beautiful

    ERIC Educational Resources Information Center

    House, Carolyn A.; Rule, Audrey C.

    2005-01-01

    Preschoolers' reasons for ranking the beauty of 30 children's book illustrations were investigated through individual interviews. Most frequent response criteria for beauty were associated with familiar objects or surroundings, action, color, clothing or accessories, water or ice, body features, and babies or small things. Children's book…

  8. Beauty, Goodness and Education: The Arts beyond Utility

    ERIC Educational Resources Information Center

    Winston, Joe

    2006-01-01

    This article takes its lead from Iris Murdoch's argument that an education in beauty can be a training in the love of virtue. Yet the word "beauty" is seldom used in contemporary educational discourse, even within the arts disciplines, where aesthetic considerations are integral to the learning process. I begin, therefore, with an examination of…

  9. Beauty in the Classroom: Instructors' Pulchritude and Putative Pedagogical Productivity

    ERIC Educational Resources Information Center

    Hamermesh, D.S.; Parker, A.

    2005-01-01

    Adjusted for many other determinants, beauty affects earnings; but does it lead directly to the differences in productivity that we believe generate earnings differences? We take a large sample of student instructional ratings for a group of university teachers and acquire six independent measures of their beauty, and a number of other descriptors…

  10. 7 CFR 650.24 - Scenic beauty (visual resource).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., May 28, 1970, “Protecting and Improving The Quality of the Environment,” includes scenic beauty as an... to the quality of the visual resource. (3) Local organizations and groups interested in scenic beauty... to those soil and water conservation measures that contribute to a productive and...

  11. 7 CFR 650.24 - Scenic beauty (visual resource).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., May 28, 1970, “Protecting and Improving The Quality of the Environment,” includes scenic beauty as an... to the quality of the visual resource. (3) Local organizations and groups interested in scenic beauty... to those soil and water conservation measures that contribute to a productive and...

  12. 7 CFR 650.24 - Scenic beauty (visual resource).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., May 28, 1970, “Protecting and Improving The Quality of the Environment,” includes scenic beauty as an... to the quality of the visual resource. (3) Local organizations and groups interested in scenic beauty... to those soil and water conservation measures that contribute to a productive and...

  13. Charm and beauty measurements at Fermilab fixed target

    SciTech Connect

    Mishra, C.S.

    1993-10-01

    Eighteen months after a successful run of the Fermilab fixed target program, interesting results from several experiments are available. This is the first time that more than one Fermilab fixed target experiment has reported the observation of beauty mesons. In this paper we review recent results from charm and beauty fixed target experiments at Fermilab.

  14. Gender Differences in the Motivational Processing of Facial Beauty

    ERIC Educational Resources Information Center

    Levy, Boaz; Ariely, Dan; Mazar, Nina; Chi, Won; Lukas, Scott; Elman, Igor

    2008-01-01

    Gender may be involved in the motivational processing of facial beauty. This study applied a behavioral probe, known to activate brain motivational regions, to healthy heterosexual subjects. Matched samples of men and women were administered two tasks: (a) key pressing to change the viewing time of average or beautiful female or male facial…

  15. The Aesthetics of Race versus the Beauty of Humanity.

    ERIC Educational Resources Information Center

    Pontynen, Arthur

    2002-01-01

    Recommends rejecting race (an aesthetic concept) and returning to the apprehension, appreciation, and realization of beauty. Discusses aesthetics and racism, racism and postmodernism, and postmodernism and despair. Explains that recognition of the continuum from aesthetics to beauty would mark the demise of aesthetics and the rise of a new and…

  16. The experience of mathematical beauty and its neural correlates

    PubMed Central

    Zeki, Semir; Romaya, John Paul; Benincasa, Dionigi M. T.; Atiyah, Michael F.

    2014-01-01

    Many have written of the experience of mathematical beauty as being comparable to that derived from the greatest art. This makes it interesting to learn whether the experience of beauty derived from such a highly intellectual and abstract source as mathematics correlates with activity in the same part of the emotional brain as that derived from more sensory, perceptually based, sources. To determine this, we used functional magnetic resonance imaging (fMRI) to image the activity in the brains of 15 mathematicians when they viewed mathematical formulae which they had individually rated as beautiful, indifferent or ugly. Results showed that the experience of mathematical beauty correlates parametrically with activity in the same part of the emotional brain, namely field A1 of the medial orbito-frontal cortex (mOFC), as the experience of beauty derived from other sources. PMID:24592230

  17. Observational Study in Ten Beauty Salons: Results Informing Development of the North Carolina BEAUTY and Health Project

    ERIC Educational Resources Information Center

    Solomon, Felicia M.; Linnan, Laura A.; Wasilewski, Yvonne; Lee, Ann Marie; Katz, Mira L.; Yang, Jingzhen

    2004-01-01

    Researchers from the North Carolina BEAUTY and Health Project conducted an observational study in 10 North Carolina beauty salons to gain insight into naturally occurring conversations between cosmetologists and customers, and to assess features of the salon environment that might be used to inform the development of salon-based health promotion…

  18. Online Responses to a Multilingual Super Bowl Ad: Is "America the Beautiful" by Any Other Language Still America, the Beautiful?

    ERIC Educational Resources Information Center

    Hoffman, Brooke Y.

    2016-01-01

    On 2 February 2014, an advertisement entitled "It's Beautiful" debuted during Super Bowl XLVIII, which was watched by 111.5 million people in the USA. The Coca-Cola advertisement portrayed people of various ethnicities and was accompanied by "America the Beautiful" sung in nine languages. Using critical discourse analysis, I…

  19. A beautiful sea: P. A. M. Dirac's epistemology and ontology of the vacuum.

    PubMed

    Wright, Aaron Sidney

    2016-07-01

    This paper charts P.A.M. Dirac's development of his theory of the electron, and its radical picture of empty space as an almost-full plenum. Dirac's Quantum Electrodynamics famously accomplished more than the unification of special relativity and quantum mechanics. It also accounted for the 'duplexity phenomena' of spectral line splitting that we now attribute to electron spin. But the extra mathematical terms that allowed for spin were not alone, and this paper charts Dirac's struggle to ignore or account for them as a sea of strange, negative-energy, particles with positive 'holes'. This work was not done in solitude, but rather in exchanges with Dirac's correspondence network. This social context for Dirac's work contests his image as a lone genius, and documents a community wrestling with the ontological consequences of their work. Unification, consistency, causality, and community are common factors in explanations in the history of physics. This paper argues on the basis of materials in Dirac's archive that --- in addition --- mathematical beauty was an epistemological factor in the development of the electron and hole theory. In fact, if we believe that Dirac's beautiful mathematics captures something of the world, then there is both an epistemology and an ontology of mathematical beauty. PMID:27093586

  20. Structural Determinants of Sleeping Beauty Transposase Activity.

    PubMed

    Abrusán, György; Yant, Stephen R; Szilágyi, András; Marsh, Joseph A; Mátés, Lajos; Izsvák, Zsuzsanna; Barabás, Orsolya; Ivics, Zoltán

    2016-08-01

    Transposases are important tools in genome engineering, and there is considerable interest in engineering more efficient ones. Here, we seek to understand the factors determining their activity using the Sleeping Beauty transposase. Recent work suggests that protein coevolutionary information can be used to classify groups of physically connected, coevolving residues into elements called "sectors", which have proven useful for understanding the folding, allosteric interactions, and enzymatic activity of proteins. Using extensive mutagenesis data, protein modeling and analysis of folding energies, we show that (i) The Sleeping Beauty transposase contains two sectors, which span across conserved domains, and are enriched in DNA-binding residues, indicating that the DNA binding and endonuclease functions of the transposase coevolve; (ii) Sector residues are highly sensitive to mutations, and most mutations of these residues strongly reduce transposition rate; (iii) Mutations with a strong effect on free energy of folding in the DDE domain of the transposase significantly reduce transposition rate. (iv) Mutations that influence DNA and protein-protein interactions generally reduce transposition rate, although most hyperactive mutants are also located on the protein surface, including residues with protein-protein interactions. This suggests that hyperactivity results from the modification of protein interactions, rather than the stabilization of protein fold. PMID:27401040

  1. The neural correlates of beauty comparison

    PubMed Central

    Mussweiler, Thomas; Mullins, Paul; Linden, David E. J.

    2014-01-01

    Beauty is in the eye of the beholder. How attractive someone is perceived to be depends on the individual or cultural standards to which this person is compared. But although comparisons play a central role in the way people judge the appearance of others, the brain processes underlying attractiveness comparisons remain unknown. In the present experiment, we tested the hypothesis that attractiveness comparisons rely on the same cognitive and neural mechanisms as comparisons of simple nonsocial magnitudes such as size. We recorded brain activity with functional magnetic resonance imaging (fMRI) while participants compared the beauty or height of two women or two dogs. Our data support the hypothesis of a common process underlying these different types of comparisons. First, we demonstrate that the distance effect characteristic of nonsocial comparisons also holds for attractiveness comparisons. Behavioral results indicated, for all our comparisons, longer response times for near than far distances. Second, the neural correlates of these distance effects overlapped in a frontoparietal network known for its involvement in processing simple nonsocial quantities. These results provide evidence for overlapping processes in the comparison of physical attractiveness and nonsocial magnitudes. PMID:23508477

  2. The neural correlates of beauty comparison.

    PubMed

    Kedia, Gayannée; Mussweiler, Thomas; Mullins, Paul; Linden, David E J

    2014-05-01

    Beauty is in the eye of the beholder. How attractive someone is perceived to be depends on the individual or cultural standards to which this person is compared. But although comparisons play a central role in the way people judge the appearance of others, the brain processes underlying attractiveness comparisons remain unknown. In the present experiment, we tested the hypothesis that attractiveness comparisons rely on the same cognitive and neural mechanisms as comparisons of simple nonsocial magnitudes such as size. We recorded brain activity with functional magnetic resonance imaging (fMRI) while participants compared the beauty or height of two women or two dogs. Our data support the hypothesis of a common process underlying these different types of comparisons. First, we demonstrate that the distance effect characteristic of nonsocial comparisons also holds for attractiveness comparisons. Behavioral results indicated, for all our comparisons, longer response times for near than far distances. Second, the neural correlates of these distance effects overlapped in a frontoparietal network known for its involvement in processing simple nonsocial quantities. These results provide evidence for overlapping processes in the comparison of physical attractiveness and nonsocial magnitudes. PMID:23508477

  3. Literary aesthetics: beauty, the brain, and Mrs. Dalloway.

    PubMed

    Hogan, Patrick Colm

    2013-01-01

    Empirical research indicates that beauty is in part a matter of prototype approximation. Some research suggests that unanticipated pattern recognition is important as well. This essay begins by briefly outlining an account of beauty based on these factors. It goes on to consider complications. Minor complications include the partial incompatibility of these accounts and the importance of differentiating judgments of beauty from aesthetic response. More serious issues include the relative neglect of literature in neurologically-based discussions of beauty, which tend to focus on music or visual art. There is also a relative neglect of emotion, beyond the reward system. Finally, there is the almost complete absence of the sublime. After considering these problems broadly, the essay turns to Virginia Woolf's Mrs. Dalloway, examining its treatment of beauty and sublimity. The aim of this section is not merely to illuminate Woolf's novel by reference to neuroscientific research. It is equally, perhaps more fully, to expand our neuroscientifically grounded account of aesthetic response by drawing on Woolf's novel. In Mrs. Dalloway, there are gestures toward prototypes and patterns in beauty. But the key features are clearly emotional. Specifically, the emotions at issue in feelings of beauty and sublimity appear to be primarily attachment, on the one hand, and a profound sense of isolation, on the other. Woolf's novel also points us toward other features of aesthetic experience, crucially including the emotion-sharing that is a key function of the production and circulation of art. PMID:24290272

  4. The 2010 interferometric imaging beauty contest

    NASA Astrophysics Data System (ADS)

    Malbet, Fabien; Cotton, William; Duvert, Gilles; Lawson, Peter; Chiavassa, Andrea; Young, John; Baron, Fabien; Buscher, David; Rengaswamy, Sridharan; Kloppenborg, Brian; Vannier, Martin; Mugnier, Laurent

    2010-07-01

    We present the results of the fourth Optical/IR Interferometry Imaging Beauty Contest. The contest consists of blind imaging of test data sets derived from model sources and distributed in the OI-FITS format. The test data consists of spectral data sets on an object "observed" in the infrared with spectral resolution. There were 4 different algorithms competing this time: BSMEM the Bispectrum Maximum Entropy Method by Young, Baron & Buscher; RPR the Recursive Phase Reconstruction by Rengaswamy; SQUEEZE a Markov Chain Monte Carlo algorithm by Baron, Monnier & Kloppenborg; and, WISARD theWeak-phase Interferometric Sample Alternating Reconstruction Device by Vannier & Mugnier. The contest model image, the data delivered to the contestants and the rules are described as well as the results of the image reconstruction obtained by each method. These results are discussed as well as the strengths and limitations of each algorithm.

  5. The 2012 interferometric imaging beauty contest

    NASA Astrophysics Data System (ADS)

    Baron, Fabien; Cotton, William D.; Lawson, Peter R.; Ridgway, Steve T.; Aarnio, Alicia; Monnier, John D.; Hofmann, Karl-Heinz; Schertl, Dieter; Weigelt, Gerd; Thiébaut, Eric; Soulez, Férréol; Mary, David; Millour, Florentin; Vannier, Martin; Young, John; Elias, Nicholas M.; Schmitt, Henrique R.; Rengaswamy, Sridharan

    2012-07-01

    We present the results of the fifth Interferometric Imaging Beauty Contest. The contest consists in blind imaging of test data sets derived from model sources and distributed in the OIFITS format. Two scenarios of imaging with CHARA/MIRC-6T were offered for reconstruction: imaging a T Tauri disc and imaging a spotted red supergiant. There were eight different teams competing this time: Monnier with the software package MACIM; Hofmann, Schertl and Weigelt with IRS; Thiebaut and Soulez with MiRA ; Young with BSMEM; Mary and Vannier with MIROIRS; Millour and Vannier with independent BSMEM and MiRA entries; Rengaswamy with an original method; and Elias with the radio-astronomy package CASA. The contest model images, the data delivered to the contestants and the rules are described as well as the results of the image reconstruction obtained by each method. These results are discussed as well as the strengths and limitations of each algorithm.

  6. Cost of Beauty; Prilocaine Induced Methemoglobinemia.

    PubMed

    Kilicli, Elif; Aksel, Gokhan; Akbuga Ozel, Betul; Kavalci, Cemil; Suveren Artuk, Dilek

    2014-12-01

    Prilocaine induced methemoglobinemia is a rare entity. In the present paper, the authors aim to draw attention to the importance of this rare condition by reporting this case. A 30-year-old female presented to Emergency Department with headache, dispnea and cyanosis. The patient has a history of 1000-1200 mg of prilocaine subcutaneous injection for hair removal at a beauty center, 5 hours ago. Tension arterial: 130/73 mmHg, pulse: 103/minute, body temperature: 37 °C and respiratory rate: 20/minute. The patient had acral and perioral cyanosis. Methemoglobin was measured 14.1% in venous blood gas test. The patient treated with 3 gr ascorbic acid intravenously. The patient was discharged free of symptoms after 48 hours of observation. Emergency physician should consider methemoglobinemia in presentation of dispnea and cyanosis after injection of prilocaine. PMID:27331187

  7. 43. 253255 AUBURN AVENUE (Jim's Place; Unisex Beauty Shop) NORTH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    43. 253-255 AUBURN AVENUE (Jim's Place; Unisex Beauty Shop) NORTH ELEVATION 44. --- PIEDMONT AVENUE (Pucker House) EAST ELEVATION - 126-255 Auburn Avenue (Commercial Buildings), Auburn Avenue, Atlanta, Fulton County, GA

  8. Isovector and hidden-beauty partners of the X(3872)

    NASA Astrophysics Data System (ADS)

    Høgaasen, Hallstein; Kou, Emi; Richard, Jean-Marc; Sorba, Paul

    2014-05-01

    The isovector partners of the X(3872), recently found at BES III, Belle and CLEO-c were predicted in a simple model based on the chromomagnetic interaction among quarks. The extension to the hidden-beauty sector is discussed.

  9. Physics of flow in the beauty therapy salon

    NASA Astrophysics Data System (ADS)

    McGoldrick, Thomas

    2006-07-01

    Physical principles involving pressure, flow rates and heating of fluids in a beauty therapy salon are discussed and quantities calculated. The salon ventilation system is used to develop a model for radioactive decay.

  10. Toward A Brain-Based Theory of Beauty

    PubMed Central

    Ishizu, Tomohiro; Zeki, Semir

    2011-01-01

    We wanted to learn whether activity in the same area(s) of the brain correlate with the experience of beauty derived from different sources. 21 subjects took part in a brain-scanning experiment using functional magnetic resonance imaging. Prior to the experiment, they viewed pictures of paintings and listened to musical excerpts, both of which they rated on a scale of 1–9, with 9 being the most beautiful. This allowed us to select three sets of stimuli–beautiful, indifferent and ugly–which subjects viewed and heard in the scanner, and rated at the end of each presentation. The results of a conjunction analysis of brain activity showed that, of the several areas that were active with each type of stimulus, only one cortical area, located in the medial orbito-frontal cortex (mOFC), was active during the experience of musical and visual beauty, with the activity produced by the experience of beauty derived from either source overlapping almost completely within it. The strength of activation in this part of the mOFC was proportional to the strength of the declared intensity of the experience of beauty. We conclude that, as far as activity in the brain is concerned, there is a faculty of beauty that is not dependent on the modality through which it is conveyed but which can be activated by at least two sources–musical and visual–and probably by other sources as well. This has led us to formulate a brain-based theory of beauty. PMID:21755004

  11. Studies of interactions between elementary particles and nuclei

    NASA Astrophysics Data System (ADS)

    Fortney, L. R.; Goshaw, A. T.; Walker, W. D.

    1990-08-01

    This report discusses the following research: Particle production in proton-antiproton collision at (radical)s = 1.8 TeV; SSC subsystems R and D; the solenoid detector collaboration particle nucleus collisions; task expenditure statement. Hadroproduction using 300 GeV particle beams Fermilab; hadroproduction of beauty Fermilab; and vector meson photo production.

  12. Mathematics make microbes beautiful, beneficial, and bountiful.

    PubMed

    Jungck, John R

    2012-01-01

    Microbiology is a rich area for visualizing the importance of mathematics in terms of designing experiments, data mining, testing hypotheses, and visualizing relationships. Historically, Nobel Prizes have acknowledged the close interplay between mathematics and microbiology in such examples as the fluctuation test and mutation rates using Poisson statistics by Luria and Delbrück and the use of graph theory of polyhedra by Caspar and Klug. More and more contemporary microbiology journals feature mathematical models, computational algorithms and heuristics, and multidimensional visualizations. While revolutions in research have driven these initiatives, a commensurate effort needs to be made to incorporate much more mathematics into the professional preparation of microbiologists. In order not to be daunting to many educators, a Bloom-like "Taxonomy of Quantitative Reasoning" is shared with explicit examples of microbiological activities for engaging students in (a) counting, measuring, calculating using image analysis of bacterial colonies and viral infections on variegated leaves, measurement of fractal dimensions of beautiful colony morphologies, and counting vertices, edges, and faces on viral capsids and using graph theory to understand self assembly; (b) graphing, mapping, ordering by applying linear, exponential, and logistic growth models of public health and sanitation problems, revisiting Snow's epidemiological map of cholera with computational geometry, and using interval graphs to do complementation mapping, deletion mapping, food webs, and microarray heatmaps; (c) problem solving by doing gene mapping and experimental design, and applying Boolean algebra to gene regulation of operons; (d) analysis of the "Bacterial Bonanza" of microbial sequence and genomic data using bioinformatics and phylogenetics; (e) hypothesis testing-again with phylogenetic trees and use of Poisson statistics and the Luria-Delbrück fluctuation test; and (f) modeling of

  13. Evaluation of facial beauty using anthropometric proportions.

    PubMed

    Milutinovic, Jovana; Zelic, Ksenija; Nedeljkovic, Nenad

    2014-01-01

    The improvement of a patient's facial appearance is one of the main goals of contemporary orthodontic treatment. The aim of this investigation was to evaluate the difference in facial proportions between attractive and anonymous females in order to establish objective facial features which are widely considered as beautiful. The study included two groups: first group consisted of 83 Caucasian female subjects between 22 and 28 years of age who were selected from the population of students at the University of Belgrade, and the second group included 24 attractive celebrity Caucasian females. The en face facial photographs were taken in natural head position (NHP). Numerous parameters were recorded on these photographs, in order to establish facial symmetry and correlation with the ideal set of proportions. This study showed significant difference between anonymous and attractive females. Attractive females showed smaller face in general and uniformity of the facial thirds and fifths, and most of the facial parameters meet the criteria of the ideal proportions. PMID:24701166

  14. Sleeping Beauty: Kleine–Levin Syndrome

    PubMed Central

    Mudgal, Soumiya; Jiloha, R. C.; Kandpal, Manish; Das, Aparna

    2014-01-01

    Kleine–Levin syndrome (KLS) alias sleeping beauty syndrome, is a rare sleep disorder. Clinically presenting as episodes of hypersomnolence, behavioral and cognitive disturbances, hyperphagia and hypersexuality. KLS may have an idiopathic onset or may be precipitated by neurological event or infection. Until date, no definite underlying cause is established and neither there are any definitive management guidelines. It remains a diagnosis of exclusion after other psychiatric and neurological causes have been ruled out. Coloring of presentation with behavioral and mood elements makes it important for a psychiatrist to be well-informed about the condition to avoid the erroneous diagnosis. KLS is a devastating illness, which robs the patient of time, experiences, and relationships. An early diagnosis and effective management can help patient escape from the morbidity caused by this disorder. Armodafinil and oxcarbamazepine have found to be effective in two of the case. The emphasis of this report is to add to the existing clinical knowledge of neurologists, psychiatrists and physicians. In the future, research is needed on genetic etiology and management of this disorder. PMID:25316944

  15. Evaluation of Facial Beauty Using Anthropometric Proportions

    PubMed Central

    Milutinovic, Jovana

    2014-01-01

    The improvement of a patient's facial appearance is one of the main goals of contemporary orthodontic treatment. The aim of this investigation was to evaluate the difference in facial proportions between attractive and anonymous females in order to establish objective facial features which are widely considered as beautiful. The study included two groups: first group consisted of 83 Caucasian female subjects between 22 and 28 years of age who were selected from the population of students at the University of Belgrade, and the second group included 24 attractive celebrity Caucasian females. The en face facial photographs were taken in natural head position (NHP). Numerous parameters were recorded on these photographs, in order to establish facial symmetry and correlation with the ideal set of proportions. This study showed significant difference between anonymous and attractive females. Attractive females showed smaller face in general and uniformity of the facial thirds and fifths, and most of the facial parameters meet the criteria of the ideal proportions. PMID:24701166

  16. The Great Beauty of the osteoclast.

    PubMed

    Cappariello, Alfredo; Maurizi, Antonio; Veeriah, Vimal; Teti, Anna

    2014-09-15

    Much has been written recently on osteoclast biology, but this cell type still astonishes scientists with its multifaceted functions and unique properties. The last three decades have seen a change in thinking about the osteoclast, from a cell with a single function, which just destroys the tissue it belongs to, to an "orchestrator" implicated in the concerted regulation of bone turnover. Osteoclasts have unique morphological features, organelle distribution and plasma membrane domain organization. They require polarization to cause extracellular bone breakdown and release of the digested bone matrix products into the circulation. Osteoclasts contribute to the control of skeletal growth and renewal. Alongside other organs, including kidney, gut, thyroid and parathyroid glands, they also affect calcemia and phosphatemia. Osteoclasts are very sensitive to pro-inflammatory stimuli, and studies in the '00s ascertained their tight link with the immune system, bringing about the question why bone needs a cell regulated by the immune system to remove the extracellular matrix components. Recently, osteoclasts have been demonstrated to contribute to the hematopoietic stem cell niche, controlling local calcium concentration and regulating the turnover of factors essential for hematopoietic stem cell mobilization. Finally, osteoclasts are important regulators of osteoblast activity and angiogenesis, both by releasing factors stored in the bone matrix, and secreting "clastokines" that regulate the activity of neighboring cells. All these facets will be discussed in this review article, with the aim of underscoring The Great Beauty of the osteoclast. PMID:24976175

  17. Defining and identifying Sleeping Beauties in science

    PubMed Central

    Ke, Qing; Ferrara, Emilio; Radicchi, Filippo; Flammini, Alessandro

    2015-01-01

    A Sleeping Beauty (SB) in science refers to a paper whose importance is not recognized for several years after publication. Its citation history exhibits a long hibernation period followed by a sudden spike of popularity. Previous studies suggest a relative scarcity of SBs. The reliability of this conclusion is, however, heavily dependent on identification methods based on arbitrary threshold parameters for sleeping time and number of citations, applied to small or monodisciplinary bibliographic datasets. Here we present a systematic, large-scale, and multidisciplinary analysis of the SB phenomenon in science. We introduce a parameter-free measure that quantifies the extent to which a specific paper can be considered an SB. We apply our method to 22 million scientific papers published in all disciplines of natural and social sciences over a time span longer than a century. Our results reveal that the SB phenomenon is not exceptional. There is a continuous spectrum of delayed recognition where both the hibernation period and the awakening intensity are taken into account. Although many cases of SBs can be identified by looking at monodisciplinary bibliographic data, the SB phenomenon becomes much more apparent with the analysis of multidisciplinary datasets, where we can observe many examples of papers achieving delayed yet exceptional importance in disciplines different from those where they were originally published. Our analysis emphasizes a complex feature of citation dynamics that so far has received little attention, and also provides empirical evidence against the use of short-term citation metrics in the quantification of scientific impact. PMID:26015563

  18. The Super Fixed Target beauty facility at the SSC

    SciTech Connect

    Lau, Kwong; The SFT Collaboration

    1991-12-31

    The rationale for pursuing beauty physics at the SSC in a fixed target configuration is described. The increased beauty production cross section at the SSC, combined with high interaction rate capability of the proposed detector, results in 10{sup 10{minus}11} produced BB events per year. The long decay length of the B hadrons ({approx_equal} 10 cm) allows direct observation of B decays in the high resolution silicon microstrip vertex detector. To optimize the operation of the proposed beauty spectrometer and the SSC, parasitic extraction of attendant or artificially generated large amplitude protons using crystal channeling is proposed and explored. The large sample of fully reconstructed B events allows detailed studies of various CP violating decays with requisite statistics to confront the standard model. The CP physics potential of the proposed experiment is evaluated and compared with alternative approaches, such as symmetric e{sup +}e{sup {minus}} B Factories and specialized hadron colliders.

  19. Measurement of beauty production with {mu}{mu} correlations

    SciTech Connect

    Longhin, A.

    2005-10-06

    Beauty production with events in which two muons are observed in the final state has been measured with the ZEUS detector at HERA using an integrated luminosity of 121 pb-1. A low pT threshold for muon identification, in combination with the large rapidity coverage of the ZEUS muon system, gives access to essentially the full phase space for beauty production. The dimuon selection suppresses backgrounds from charm and light flavor production. Separation of the sample into high and low-mass, isolated and non-isolated, like and unlike-sign muon pairs offers redundancy which is used to further constrain the backgrounds. A total cross section for beauty production at HERA is obtained and compared to QCD predictions.

  20. Predicting beauty: fractal dimension and visual complexity in art.

    PubMed

    Forsythe, A; Nadal, M; Sheehy, N; Cela-Conde, C J; Sawey, M

    2011-02-01

    Visual complexity has been known to be a significant predictor of preference for artistic works for some time. The first study reported here examines the extent to which perceived visual complexity in art can be successfully predicted using automated measures of complexity. Contrary to previous findings the most successful predictor of visual complexity was Gif compression. The second study examined the extent to which fractal dimension could account for judgments of perceived beauty. The fractal dimension measure accounts for more of the variance in judgments of perceived beauty in visual art than measures of visual complexity alone, particularly for abstract and natural images. Results also suggest that when colour is removed from an artistic image observers are unable to make meaningful judgments as to its beauty. PMID:21241285

  1. E789 and P865: High-rate fixed-target studies of charm and beauty

    SciTech Connect

    Kaplan, D.M.

    1993-06-01

    Experiment 789 at Fermilab used the high-rate E605/E772 spectrometer to study low-multiplicity charm and beauty decays. Preliminary results on charm and beauty production are presented based on analysis of [approx] 100% of the charm data and [approx] 50% of the beauty data. A new experiment is proposed to improve charm and beauty sensitivity by several orders of magnitude.

  2. Estrogen formulations and beauty care practices in Japanese women

    PubMed Central

    Takeda, Takashi; Wong, Tze Fang; Kitamura, Mari; Yaegashi, Nobuo

    2012-01-01

    Purpose Traditionally, oral estrogens have been used for hormone replacement therapy. However, in Japan, additional estrogen formulations have been used, including transdermal patches and transdermal gels. The latter have a unique commonality with cosmetics because both of them are applied to the skin. Beauty care is one of the most important lifestyle factors for women, and it has been reported that the amount of attention paid to beauty care has an effect in determining whether or not women will choose to undergo HRT during menopause. Therefore, our study focused on estrogen formulations and beauty care practices. Patients and methods Fifty women who use hormone replacement therapy were recruited from the outpatient clinic of Tohoku University Hospital. They were treated with oral conjugated estrogen (n = 11), transdermal 17β-estradiol patch (n = 11), and transdermal 17β-estradiol gel (n = 28). They completed a questionnaire to assess their lifestyle (beauty care practices and exercise habits) and their compliance. The transdermal gel users were further interviewed about their subjective impressions regarding “smell”, “sticky feeling”, “spreadability”, and “irritation” on the skin using a five-grade scale. Results There were no differences in the usability of medicines and patient compliance among the estrogen formulations. We observed a positive tendency between the level of beauty care and transdermal gel use (P = 0.0645, ordinary logistic regression analysis). The gel users placed top priority on a lack of “sticky feeling” but the subjective impression regarding “sticky feeling” was worst among the four factors (P < 0.01, Steel–Dwass test). Correspondence analysis showed that the subjective impressions of transdermal gel corresponding to usability in the range of “moderate” to “very good” and “sticky feeling” greatly affected the usability of the formulation. Conclusion These results suggest that the level of attention

  3. The Golden Beauty: Brain Response to Classical and Renaissance Sculptures

    PubMed Central

    Di Dio, Cinzia; Macaluso, Emiliano; Rizzolatti, Giacomo

    2007-01-01

    Is there an objective, biological basis for the experience of beauty in art? Or is aesthetic experience entirely subjective? Using fMRI technique, we addressed this question by presenting viewers, naïve to art criticism, with images of masterpieces of Classical and Renaissance sculpture. Employing proportion as the independent variable, we produced two sets of stimuli: one composed of images of original sculptures; the other of a modified version of the same images. The stimuli were presented in three conditions: observation, aesthetic judgment, and proportion judgment. In the observation condition, the viewers were required to observe the images with the same mind-set as if they were in a museum. In the other two conditions they were required to give an aesthetic or proportion judgment on the same images. Two types of analyses were carried out: one which contrasted brain response to the canonical and the modified sculptures, and one which contrasted beautiful vs. ugly sculptures as judged by each volunteer. The most striking result was that the observation of original sculptures, relative to the modified ones, produced activation of the right insula as well as of some lateral and medial cortical areas (lateral occipital gyrus, precuneus and prefrontal areas). The activation of the insula was particularly strong during the observation condition. Most interestingly, when volunteers were required to give an overt aesthetic judgment, the images judged as beautiful selectively activated the right amygdala, relative to those judged as ugly. We conclude that, in observers naïve to art criticism, the sense of beauty is mediated by two non-mutually exclusive processes: one based on a joint activation of sets of cortical neurons, triggered by parameters intrinsic to the stimuli, and the insula (objective beauty); the other based on the activation of the amygdala, driven by one's own emotional experiences (subjective beauty). PMID:18030335

  4. A Conceptual Overview of the Role of Beauty and Aesthetics in Science and Science Education

    ERIC Educational Resources Information Center

    Girod, Mark

    2007-01-01

    Conversations on the connection of art, beauty, and the aesthetic experience in science are gaining a voice in the science education community. This article provides a conceptual overview of the role of beauty and aesthetics in science and science education. It focuses on a discussion of four themes exploring beauty in scientific ideas and…

  5. Beauty and Intelligence May--or May Not--Be Related

    ERIC Educational Resources Information Center

    Denny, Kevin

    2008-01-01

    In a recent paper, [Kanazawa S. & Kovar J.L. (2004). Why beautiful people are more intelligent, "Intelligence," 32, 227-243] assert that given certain empirical regularities about assortative mating and the heritability of intelligence and beauty, that it logically follows that more intelligent people are more beautiful. It is argued here that…

  6. Beauty is as beauty does: body image and self-esteem of pageant contestants.

    PubMed

    Thompson, S H; Hammond, K

    2003-09-01

    Self-esteem, dieting, and body image of 131 female beauty pageant contestants (mean age 26.0 years) from 43 states were examined by an anonymous survey. Most (89.6%) reported being a pageant finalist or winner and 55.2% had competed at the nationa/international level Over one-fourth (26%) of the women had been told or perceived they had an eating disorder which reportedly began at 16.25 years. Almost half (48.5%) reported wanting to be thinner and 57% were trying to lose weight. Higher self-esteem scores were significantly associated with increased level of competition (i.e.: from local to international pageants), but not with the number of times the women were pageant finalists or winners. Future study is warranted to determine how pageant participation influences self-esteem, body image, and the development of eating disorders. PMID:14649788

  7. Beauty photoproduction using decays into electrons at HERA

    SciTech Connect

    Chekanov, S.; Derrick, M.; Magill, S.; Musgrave, B.; Nicholass, D.; Repond, J.; Yoshida, R.; Mattingly, M. C. K.; Antonioli, P.; Bari, G.; Bellagamba, L.; Boscherini, D.; Bruni, A.; Bruni, G.; Cindolo, F.; Corradi, M.; Iacobucci, G.; Margotti, A.; Nania, R.; Polini, A.

    2008-10-01

    Photoproduction of beauty quarks in events with two jets and an electron associated with one of the jets has been studied with the ZEUS detector at HERA using an integrated luminosity of 120 pb{sup -1}. The fractions of events containing b quarks, and also of events containing c quarks, were extracted from a likelihood fit using variables sensitive to electron identification as well as to semileptonic decays. Total and differential cross sections for beauty and charm production were measured and compared with next-to-leading-order QCD calculations and Monte Carlo models.

  8. Neural correlates of visual aesthetics--beauty as the coalescence of stimulus and internal state.

    PubMed

    Jacobs, Richard H A H; Renken, Remco; Cornelissen, Frans W

    2012-01-01

    How do external stimuli and our internal state coalesce to create the distinctive aesthetic pleasures that give vibrance to human experience? Neuroaesthetics has so far focused on the neural correlates of observing beautiful stimuli compared to neutral or ugly stimuli, or on neural correlates of judging for beauty as opposed to other judgments. Our group questioned whether this approach is sufficient. In our view, a brain region that assesses beauty should show beauty-level-dependent activation during the beauty judgment task, but not during other, unrelated tasks. We therefore performed an fMRI experiment in which subjects judged visual textures for beauty, naturalness and roughness. Our focus was on finding brain activation related to the rated beauty level of the stimuli, which would take place exclusively during the beauty judgment. An initial whole-brain analysis did not reveal such interactions, yet a number of the regions showing main effects of the judgment task or the beauty level of stimuli were selectively sensitive to beauty level during the beauty task. Of the regions that were more active during beauty judgments than roughness judgments, the frontomedian cortex and the amygdala demonstrated the hypothesized interaction effect, while the posterior cingulate cortex did not. The latter region, which only showed a task effect, may play a supporting role in beauty assessments, such as attending to one's internal state rather than the external world. Most of the regions showing interaction effects of judgment and beauty level correspond to regions that have previously been implicated in aesthetics using different stimulus classes, but based on either task or beauty effects alone. The fact that we have now shown that task-stimulus interactions are also present during the aesthetic judgment of visual textures implies that these areas form a network that is specifically devoted to aesthetic assessment, irrespective of the stimulus type. PMID:22384006

  9. Neural Correlates of Visual Aesthetics – Beauty as the Coalescence of Stimulus and Internal State

    PubMed Central

    Jacobs, Richard H. A. H.; Renken, Remco; Cornelissen, Frans W.

    2012-01-01

    How do external stimuli and our internal state coalesce to create the distinctive aesthetic pleasures that give vibrance to human experience? Neuroaesthetics has so far focused on the neural correlates of observing beautiful stimuli compared to neutral or ugly stimuli, or on neural correlates of judging for beauty as opposed to other judgments. Our group questioned whether this approach is sufficient. In our view, a brain region that assesses beauty should show beauty-level-dependent activation during the beauty judgment task, but not during other, unrelated tasks. We therefore performed an fMRI experiment in which subjects judged visual textures for beauty, naturalness and roughness. Our focus was on finding brain activation related to the rated beauty level of the stimuli, which would take place exclusively during the beauty judgment. An initial whole-brain analysis did not reveal such interactions, yet a number of the regions showing main effects of the judgment task or the beauty level of stimuli were selectively sensitive to beauty level during the beauty task. Of the regions that were more active during beauty judgments than roughness judgments, the frontomedian cortex and the amygdala demonstrated the hypothesized interaction effect, while the posterior cingulate cortex did not. The latter region, which only showed a task effect, may play a supporting role in beauty assessments, such as attending to one's internal state rather than the external world. Most of the regions showing interaction effects of judgment and beauty level correspond to regions that have previously been implicated in aesthetics using different stimulus classes, but based on either task or beauty effects alone. The fact that we have now shown that task-stimulus interactions are also present during the aesthetic judgment of visual textures implies that these areas form a network that is specifically devoted to aesthetic assessment, irrespective of the stimulus type. PMID:22384006

  10. [Esthetic nutrition: body and beauty enhancement through nutritional care].

    PubMed

    Witt, Juliana da Silveira Gonçalves Zanini; Schnider, Aline Petter

    2011-09-01

    Nowadays, there is an increasing quest for beauty and the models proposed by fashion goods and service segments, to achieve the perfect body. The standard of beauty corresponds to a thin body, without considering health aspects. The number of women who go on diets to control weight is increasing; and taking this into consideration the objective of this study is to conduct a bibliographical review and extract data on esthetics and body image to support the practice of nutritional care. Socio-cultural aspects, which motivate the quest for the perfect body, as well as body, beauty, esthetics, nutritional counseling and cognitive behavior therapy were examined in this survey. On the basis of this work, it is possible to conclude that the continuing obsession with the body may lead the person to go on diets and other drastic methods to control weight, such as surgical procedures. In this respect, nutritional care is far more than merely recommending a standard diet or giving information, as it represents providing an effective model for nutritional reeducation, prioritizing improvement in the style and quality of life. This article provides data about enhancing esthetics and beauty by means of appropriate nutrition. PMID:21987334

  11. Cosmetology Curriculum and Training as Seen by Beauty Salons.

    ERIC Educational Resources Information Center

    San Mateo Coll., CA.

    To evaluate the effectiveness of its cosmetology program, the College of San Mateo sent a questionnaire to beauty salons in the college's service area. Of the 70 questionnaires sent, over half were returned. Eleven courses in the curriculum were ranked by the employer in order of importance to him, the first four being the 1,600 hours of…

  12. Beauty and the Beholder: A Survey of Aesthetic Experiences

    ERIC Educational Resources Information Center

    Winter, Bill

    2014-01-01

    This study explored the nature of "aesthetic experience" in a sample of urban community college students (N=170). The majority of students claimed to have had experiences of beauty, and that these experiences were important to their quality of life (95% and 72%, respectively). Strongest "depth of experience" ratings were given…

  13. Small Is Beautiful: Innovation from the Inside Out.

    ERIC Educational Resources Information Center

    Larson, Robert L.

    1991-01-01

    Educators should encourage the "small is beautiful" approach to school improvement because it mobilizes a powerful "inside out" process instrumental to organizational effectiveness. As a study of two rural Vermont high schools shows, creative ways are needed to channel and maximize innovation without dampening the dynamics of marketplace effects.…

  14. Measurement of beauty hadron spectroscopy and productions at CMS

    NASA Astrophysics Data System (ADS)

    Gandrajula, Reddy Pratap

    2014-03-01

    The large production cross-sections at LHC energies, combined with a adapted trigger strategy and good detector resolutions, has enabled CMS to collect large data samples and to perform detailed studies of Beauty hadron properties. In this talk we will report our latest results, including decay rate measurements from B hadrons and spectroscopy.

  15. Beauty vector meson decay constants from QCD sum rules

    NASA Astrophysics Data System (ADS)

    Lucha, Wolfgang; Melikhov, Dmitri; Simula, Silvano

    2016-01-01

    We present the outcomes of a very recent investigation of the decay constants of nonstrange and strange heavy-light beauty vector mesons, with special emphasis on the ratio of any such decay constant to the decay constant of the corresponding pseudoscalar meson, by means of Borel-transformed QCD sum rules. Our results suggest that both these ratios are below unity.

  16. Um Olhar sobre "Beleza Americana" (A Look at "American Beauty").

    ERIC Educational Resources Information Center

    Bissoto, Maria Luisa

    2000-01-01

    Discusses the film "American Beauty" in light of a reading of Karl Marx. Finds that the film shows the circularity which marks bourgeois society, even though the rhythm of industry and renovation of the society masks it. States that Marx praises the industry, invention, and innovation of the bourgeoisie. (BT)

  17. The "F" Word: Is Feminism Incompatible with Beauty and Romance?

    ERIC Educational Resources Information Center

    Rudman, Laurie A.; Fairchild, Kimberly

    2007-01-01

    Three studies examined the predictive utility of heterosexual relationship concerns vis-a-vis support for feminism. Study 1 showed that beauty is perceived to be at odds with feminism, for both genders. The stereotype that feminists are unattractive was robust, but fully accounted for by romance-related attributions. Moreover, more attractive…

  18. Competing motivational discourses for weight loss: means to ends and the nexus of beauty and health.

    PubMed

    Kwan, Samantha

    2009-09-01

    Western cultural discourses generally deem fat unhealthy and unattractive, providing strong motivation for body nonconformists to lose weight. Semistructured interviews with 42 overweight and obese participants illuminate how individuals understand health and beauty weight-loss motivations and the relationship between the two. Interviews indicate that health and beauty motivate because they are seen as means to various ends. Specifically, participants aspire to health to fulfill various social roles and to live long, meaningful lives. Moreover, they aspire to conventional beauty ideals hoping that aesthetic conformity will elicit benefits, both psychological and social. Interviews also illustrate an intertwining of discourses in which participants conflate beauty and health in three ways: indicating that depictions of the beauty ideal are depictions of the health ideal; using beauty indicators as health indicators; and employing beauty as a motivator for health goals. This article concludes with a discussion of the health, social, and policy implications of these findings. PMID:19690204

  19. Measurement of beauty and charm production in deep inelastic scattering at HERA and measurement of the beauty-quark mass

    NASA Astrophysics Data System (ADS)

    Abramowicz, H.; Abt, I.; Adamczyk, L.; Adamus, M.; Aggarwal, R.; Antonelli, S.; Arslan, O.; Aushev, V.; Aushev, Y.; Bachynska, O.; Barakbaev, A. N.; Bartosik, N.; Behnke, O.; Behr, J.; Behrens, U.; Bertolin, A.; Bhadra, S.; Bloch, I.; Bokhonov, V.; Boos, E. G.; Borras, K.; Brock, I.; Brugnera, R.; Bruni, A.; Brzozowska, B.; Bussey, P. J.; Caldwell, A.; Capua, M.; Catterall, C. D.; Chwastowski, J.; Ciborowski, J.; Ciesielski, R.; Cooper-Sarkar, A. M.; Corradi, M.; Corriveau, F.; D'Agostini, G.; Dementiev, R. K.; Devenish, R. C. E.; Dolinska, G.; Drugakov, V.; Dusini, S.; Ferrando, J.; Figiel, J.; Foster, B.; Gach, G.; Garfagnini, A.; Geiser, A.; Gizhko, A.; Gladilin, L. K.; Gogota, O.; Golubkov, Yu. A.; Grebenyuk, J.; Gregor, I.; Grzelak, G.; Gueta, O.; Guzik, M.; Hain, W.; Hartner, G.; Hochman, D.; Hori, R.; Ibrahim, Z. A.; Iga, Y.; Ishitsuka, M.; Iudin, A.; Januschek, F.; Kadenko, I.; Kananov, S.; Kanno, T.; Karshon, U.; Kaur, M.; Kaur, P.; Khein, L. A.; Kisielewska, D.; Klanner, R.; Klein, U.; Kondrashova, N.; Kononenko, O.; Korol, Ie.; Korzhavina, I. A.; Kotanski, A.; Kötz, U.; Kovalchuk, N.; Kowalski, H.; Kuprash, O.; Kuze, M.; Levchenko, B. B.; Levy, A.; Libov, V.; Limentani, S.; Lisovyi, M.; Lobodzinska, E.; Lohmann, W.; Löhr, B.; Lohrmann, E.; Longhin, A.; Lontkovskyi, D.; Lukina, O. Yu.; Maeda, J.; Makarenko, I.; Malka, J.; Martin, J. F.; Mergelmeyer, S.; Mohamad Idris, F.; Mujkic, K.; Myronenko, V.; Nagano, K.; Nigro, A.; Nobe, T.; Notz, D.; Nowak, R. J.; Olkiewicz, K.; Onishchuk, Yu.; Paul, E.; Perlanski, W.; Perrey, H.; Pokrovskiy, N. S.; Proskuryakov, A. S.; Przybycien, M.; Raval, A.; Roloff, P.; Rubinsky, I.; Ruspa, M.; Samojlov, V.; Saxon, D. H.; Schioppa, M.; Schmidke, W. B.; Schneekloth, U.; Schörner-Sadenius, T.; Schwartz, J.; Shcheglova, L. M.; Shehzadi, R.; Shevchenko, R.; Shkola, O.; Singh, I.; Skillicorn, I. O.; Slominski, W.; Sola, V.; Solano, A.; Spiridonov, A.; Stanco, L.; Stefaniuk, N.; Stern, A.; Stewart, T. P.; Stopa, P.; Sztuk-Dambietz, J.; Szuba, D.; Szuba, J.; Tassi, E.; Temiraliev, T.; Tokushuku, K.; Tomaszewska, J.; Trofymov, A.; Trusov, V.; Tsurugai, T.; Turcato, M.; Turkot, O.; Tymieniecka, T.; Verbytskyi, A.; Viazlo, O.; Walczak, R.; Wan Abdullah, W. A. T.; Wichmann, K.; Wing, M.; Wolf, G.; Yamada, S.; Yamazaki, Y.; Zakharchuk, N.; Żarnecki, A. F.; Zawiejski, L.; Zenaiev, O.; Zhautykov, B. O.; Zhmak, N.; Zotkin, D. S.

    2014-09-01

    The production of beauty and charm quarks in ep interactions has been studied with the ZEUS detector at HERA for exchanged four-momentum squared 5 < Q 2 < 1000 GeV2 using an integrated luminosity of 354 pb-1. The beauty and charm content in events with at least one jet have been extracted using the invariant mass of charged tracks associated with secondary vertices and the decay-length significance of these vertices. Differential cross sections as a function of Q 2, Bjorken x, jet trans- verse energy and pseudorapidity were measured and compared with next-to-leading-order QCD calculations. The beauty and charm contributions to the proton structure functions were extracted from the double-differential cross section as a function of x and Q 2. The running beauty-quark mass, m b at the scale m b , was determined from a QCD fit at next-to-leading order to HERA data for the first time and found to be m b ( m b ) = 4.07 ± 0.14 (fit){-/0.07 + 0.01}(mod.){-/0.00 + 0.05}(param.){-/0.05 + 0.08}(theo.) GeV.

  20. Measurement of beauty and charm production in deep inelastic scattering at HERA and measurement of the beauty-quark mass

    NASA Astrophysics Data System (ADS)

    Abramowicz, H.; Abt, I.; Adamczyk, L.; Adamus, M.; Aggarwal, R.; Antonelli, S.; Arslan, O.; Aushev, V.; Aushev, Y.; Bachynska, O.; Barakbaev, A. N.; Bartosik, N.; Behnke, O.; Behr, J.; Behrens, U.; Bertolin, A.; Bhadra, S.; Bloch, I.; Bokhonov, V.; Boos, E. G.; Borras, K.; Brock, I.; Brugnera, R.; Bruni, A.; Brzozowska, B.; Bussey, P. J.; Caldwell, A.; Capua, M.; Catterall, C. D.; Chwastowski, J.; Ciborowski, J.; Ciesielski, R.; Cooper-Sarkar, A. M.; Corradi, M.; Corriveau, F.; D'Agostini, G.; Dementiev, R. K.; Devenish, R. C. E.; Dolinska, G.; Drugakov, V.; Dusini, S.; Ferrando, J.; Figiel, J.; Foster, B.; Gach, G.; Garfagnini, A.; Geiser, A.; Gizhko, A.; Gladilin, L. K.; Gogota, O.; Golubkov, Yu. A.; Grebenyuk, J.; Gregor, I.; Grzelak, G.; Gueta, O.; Guzik, M.; Hain, W.; Hartner, G.; Hochman, D.; Hori, R.; Ibrahim, Z. A.; Iga, Y.; Ishitsuka, M.; Iudin, A.; Januschek, F.; Kadenko, I.; Kananov, S.; Kanno, T.; Karshon, U.; Kaur, M.; Kaur, P.; Khein, L. A.; Kisielewska, D.; Klanner, R.; Klein, U.; Kondrashova, N.; Kononenko, O.; Korol, Ie.; Korzhavina, I. A.; Kotanski, A.; Kötz, U.; Kovalchuk, N.; Kowalski, H.; Kuprash, O.; Kuze, M.; Levchenko, B. B.; Levy, A.; Libov, V.; Limentani, S.; Lisovyi, M.; Lobodzinska, E.; Lohmann, W.; Löhr, B.; Lohrmann, E.; Longhin, A.; Lontkovskyi, D.; Lukina, O. Yu.; Maeda, J.; Makarenko, I.; Malka, J.; Martin, J. F.; Mergelmeyer, S.; Mohamad Idris, F.; Mujkic, K.; Myronenko, V.; Nagano, K.; Nigro, A.; Nobe, T.; Notz, D.; Nowak, R. J.; Olkiewicz, K.; Onishchuk, Yu.; Paul, E.; Perlanski, W.; Perrey, H.; Pokrovskiy, N. S.; Proskuryakov, A. S.; Przybycien, M.; Raval, A.; Roloff, P.; Rubinsky, I.; Ruspa, M.; Samojlov, V.; Saxon, D. H.; Schioppa, M.; Schmidke, W. B.; Schneekloth, U.; Schörner-Sadenius, T.; Schwartz, J.; Shcheglova, L. M.; Shehzadi, R.; Shevchenko, R.; Shkola, O.; Singh, I.; Skillicorn, I. O.; Slominski, W.; Sola, V.; Solano, A.; Spiridonov, A.; Stanco, L.; Stefaniuk, N.; Stern, A.; Stewart, T. P.; Stopa, P.; Sztuk-Dambietz, J.; Szuba, D.; Szuba, J.; Tassi, E.; Temiraliev, T.; Tokushuku, K.; Tomaszewska, J.; Trofymov, A.; Trusov, V.; Tsurugai, T.; Turcato, M.; Turkot, O.; Tymieniecka, T.; Verbytskyi, A.; Viazlo, O.; Walczak, R.; Wan Abdullah, W. A. T.; Wichmann, K.; Wing, M.; Wolf, G.; Yamada, S.; Yamazaki, Y.; Zakharchuk, N.; Żarnecki, A. F.; Zawiejski, L.; Zenaiev, O.; Zhautykov, B. O.; Zhmak, N.; Zotkin, D. S.

    2014-10-01

    The production of beauty and charm quarks in ep interactions has been studied with the ZEUS detector at HERA for exchanged four-momentum squared 5 < Q 2 < 1000 GeV2 using an integrated luminosity of 354 pb-1. The beauty and charm content in events with at least one jet have been extracted using the invariant mass of charged tracks associated with secondary vertices and the decay-length significance of these vertices. Differential cross sections as a function of Q 2, Bjorken x, jet trans- verse energy and pseudorapidity were measured and compared with next-to-leading-order QCD calculations. The beauty and charm contributions to the proton structure functions were extracted from the double-differential cross section as a function of x and Q 2. The running beauty-quark mass, m b at the scale m b , was determined from a QCD fit at next-to-leading order to HERA data for the first time and found to be m b ( m b ) = 4.07 ± 0.14 (fit){-/0.07 + 0.01}(mod.){-/0.00 + 0.05}(param.){-/0.05 + 0.08}(theo.) GeV.

  1. Perceived beauty of random texture patterns: A preference for complexity.

    PubMed

    Friedenberg, Jay; Liby, Bruce

    2016-07-01

    We report two experiments on the perceived aesthetic quality of random density texture patterns. In each experiment a square grid was filled with a progressively larger number of elements. Grid size in Experiment 1 was 10×10 with elements added to create a variety of textures ranging from 10%-100% fill levels. Participants rated the beauty of the patterns. Average judgments across all observers showed an inverted U-shaped function that peaked near middle densities. In Experiment 2 grid size was increased to 15×15 to see if observers preferred patterns with a fixed density or a fixed number of elements. The results of the second experiment were nearly identical to that of the first showing a preference for density over fixed element number. Ratings in both studies correlated positively with a GIF compression metric of complexity and with edge length. Within the range of stimuli used, observers judge more complex patterns to be more beautiful. PMID:27155800

  2. Penta-Quark States with Strangeness, Hidden Charm and Beauty

    NASA Astrophysics Data System (ADS)

    Wu, Jia-Jun; Zou, Bing-Song

    The classical quenched quark models with three constituent quarks provide a good description for the baryon spatial ground states, but fail to reproduce the spectrum of baryon excited states. More and more evidences suggest that unquenched effects with multi-quark dynamics are necessary ingredients to solve the problem. Several new hyperon resonances reported recently could fit in the picture of penta-quark states. Based on this picture, some new hyperon excited states were predicted to exist; meanwhile with extension from strangeness to charm and beauty, super-heavy narrow N* and Λ* resonances with hidden charm or beauty were predicted to be around 4.3 and 11 GeV, respectively. Recently, two of such N* with hidden charm might have been observed by the LHCb experiment. More of those states are expected to be observed in near future. This opens a new window in order to study hadronic dynamics for the multi-quark states.

  3. On charm and beauty decays: A theorist's perspective

    SciTech Connect

    Bigi, I.I.

    1987-10-01

    The present understanding of charm and bottom decays is reviewed. Special emphasis is placed on discussing the theoretical uncertainties in view of the particularly rich harvest of new data from the last year. A semi-quantitative description of D decays has emerged enabling us to address rather detailed and relatively subtle questions there, like on once and twice Cabibbo suppressed decays. Beauty physics having left its infancy is now in its adolescence; its future development towards maturity is analyzed.

  4. Hadron spectroscopy from strangeness to charm and beauty

    NASA Astrophysics Data System (ADS)

    Zou, B. S.

    2013-09-01

    Quarks of different flavors have different masses, which will cause breaking of flavor symmetries of QCD. Flavor symmetries and their breaking in hadron spectroscopy play important role for understanding the internal structures of hadrons. Hadron spectroscopy with strangeness reveals the importance of unquenched quark dynamics. Systematic study of hadron spectroscopy with strange, charm and beauty quarks would be very revealing and essential for understanding the internal structure of hadrons and its underlying quark dynamics.

  5. Measurement of open beauty production in photoproduction at HERA

    NASA Astrophysics Data System (ADS)

    ZEUS Collaboration; Breitweg, J.; et al.

    2001-01-01

    The production and semi-leptonic decay of heavy quarks have been studied in the photoproduction process e+p -> e+ + dijet + e- + X with the ZEUS detector at HERA using an integrated luminosity of 38.5 pb -1. Events with photon-proton centre-of-mass energies, Wγ p, between 134 and 269 GeV and a photon virtuality, Q2, less than 1 GeV 2 were selected requiring at least two jets of transverse energy ET jet1(2) >7(6) GeV and an electron in the final state. The electrons were identified by employing the ionisation energy loss measurement. The contribution of beauty quarks was determined using the transverse momentum of the electron relative to the axis of the closest jet, pT rel. The data, after background subtraction, were fit with a Monte Carlo simulation including beauty and charm decays. The measured beauty cross section was extrapolated to the parton level with the b quark restricted to the region of transverse momentum pT^b > pT^min = 5 GeV and pseudorapidity |η b| < 2. The extrapolated cross section is 1.6 +/- 0.4 (stat.)+0.3-0.5 (syst.) +0.2-0.4 (ext.) nb. The result is compared to a perturbative QCD calculation performed to next-to-leading order.

  6. Beauty and healing: examining sociocultural expectations of the embodied goddess.

    PubMed

    Yeh, Jin-Tsann; Lin, Chyong-Ling

    2013-03-01

    Studies indicate mental health improvement can occur via religious communities offering social support and other resources. Many people from many cultures regard medicine as a supernatural or magical treatment that can somehow lead to a better state of living. In medical advertising, female role portrayal involves the blending of beauty, ritual and attractiveness in combination with the best product image. A Chinese saying suggests that, "A girl will doll herself up for him who loves her." Female role attraction is a very important ethical subject in gender issues. Moving forward in time, female role visualization and consumption in medical advertising reveal depictions that encouraged women to do some self-searching and find, or develop, inner strength. This study is designed to examine female role portrayals in a restricted patriarchal society. The results indicate that the ideology of motherhood is an accepted social orientation that the public readily identifies with. Results further indicate that beautification through medical products incorporates an emotional element of religious healing and that the objectification of beauty in the media reveals a possible neglect of women's internal beauty. PMID:21360223

  7. Directed altruistic living donation: what is wrong with the beauty contest?

    PubMed Central

    Moorlock, Greg

    2015-01-01

    This paper explores the specific criticism of directed altruistic living organ donation that it creates a ‘beauty contest’ between potential recipients of organs. The notion of the beauty contest in transplantation was recently used by Neidich et al who stated that ‘[a]ltruism should be the guiding motivation for all donations, and when it [is], there is no place for a beauty contest’. I examine this beauty contest objection from two perspectives. First, I argue that, when considered against the behaviour of donors, this objection cannot be consistently raised without also objecting to other common aspects of organ donation. I then explore the beauty contest objection from the perspective of recipients, and argue that if the beauty contest is objectionable, it is because of a tension between recipient behaviour and the altruism that supposedly underpins the donation system. I conclude by briefly questioning the importance of this tension in light of the organ shortage. PMID:26126975

  8. Directed altruistic living donation: what is wrong with the beauty contest?

    PubMed

    Moorlock, Greg

    2015-11-01

    This paper explores the specific criticism of directed altruistic living organ donation that it creates a 'beauty contest' between potential recipients of organs. The notion of the beauty contest in transplantation was recently used by Neidich et al who stated that '[a]ltruism should be the guiding motivation for all donations, and when it [is], there is no place for a beauty contest'. I examine this beauty contest objection from two perspectives. First, I argue that, when considered against the behaviour of donors, this objection cannot be consistently raised without also objecting to other common aspects of organ donation. I then explore the beauty contest objection from the perspective of recipients, and argue that if the beauty contest is objectionable, it is because of a tension between recipient behaviour and the altruism that supposedly underpins the donation system. I conclude by briefly questioning the importance of this tension in light of the organ shortage. PMID:26126975

  9. What is beautiful is good because what is beautiful is desired: physical attractiveness stereotyping as projection of interpersonal goals.

    PubMed

    Lemay, Edward P; Clark, Margaret S; Greenberg, Aaron

    2010-03-01

    The authors posit that the attribution of desirable interpersonal qualities to physically attractive targets is a projection of interpersonal goals; people desire to form and maintain close social bonds with attractive targets and then project these motivations onto those targets. Three studies support this model. Tendencies to see attractive novel targets depicted in photographs (Study 1), attractive romantic partners (Study 2), and attractive friends (Study 3) as especially interpersonally receptive and responsive were explained by perceivers' heightened desires to bond with attractive individuals. Additional findings regarding response latencies (Study 1) also supported this model. Many instances of the "beautiful is good" effect may not reflect stereotyping as it is typically construed. Rather, they may reflect projection of heightened desires to bond with beautiful people. PMID:20179314

  10. Physical attractiveness biases in ratings of employment suitability: tracking down the "beauty is beastly" effect.

    PubMed

    Johnson, Stefanie K; Podratz, Kenneth E; Dipboye, Robert L; Gibbons, Ellie

    2010-01-01

    The "what is beautiful is good" heuristic suggests that physically attractive persons benefit from their attractiveness in a large range of situations, including perceptions of employment suitability. Conversely, the "beauty is beastly" effect suggests that attractiveness can be detrimental to women in certain employment contexts, although these findings have been less consistent than those for the "what is beautiful is good" effect. The current research seeks to uncover situations in which beauty might be detrimental for female applicants. In two studies, we found that attractiveness can be detrimental for women applying for masculine sex-typed jobs for which physical appearance is perceived as unimportant. PMID:20575336

  11. The ratio of the beauty structure functions Rb=FLb/F2b at low x

    NASA Astrophysics Data System (ADS)

    Boroun, G. R.

    2014-07-01

    We study the structure functions Fkb(x,Q2) (k=2,L) and the reduced cross section σrb(x,Q2) for small values of Bjorken's x variable with respect to the hard (Lipatov) pomeron for the gluon distribution and provide a compact formula for the ratio Rb that is useful to extract the beauty structure function from the beauty reduced cross section, in particular at DESY HERA. Also we show that the effects of the nonlinear corrections to the gluon distribution tame the behavior of the beauty structure function and the beauty reduced cross section at low x.

  12. Research in elementary particle physics. [Ohio State Univ. , Columbus

    SciTech Connect

    Not Available

    1992-01-01

    Experimental and theoretical work on high energy physics is reviewed. Included are preparations to study high-energy electron-proton interactions at HERA, light-cone QCD, decays of charm and beauty particles, neutrino oscillation, electron-positron interactions at CLEO II, detector development, and astrophysics and cosmology.

  13. 77 FR 61661 - Price for the American Eagle Silver Proof and Uncirculated Coins and the America the Beautiful...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-10

    ... Beautiful Five Ounce Silver Uncirculated Coins\\TM\\ AGENCY: United States Mint, Department of the Treasury... Beautiful Five Ounce Silver Uncirculated Coins\\TM\\ as follows: Coin New price 2012 American Eagle...

  14. Human facial beauty : Averageness, symmetry, and parasite resistance.

    PubMed

    Thornhill, R; Gangestad, S W

    1993-09-01

    It is hypothesized that human faces judged to be attractive by people possess two features-averageness and symmetry-that promoted adaptive mate selection in human evolutionary history by way of production of offspring with parasite resistance. Facial composites made by combining individual faces are judged to be attractive, and more attractive than the majority of individual faces. The composites possess both symmetry and averageness of features. Facial averageness may reflect high individual protein heterozygosity and thus an array of proteins to which parasites must adapt. Heterozygosity may be an important defense of long-lived hosts against parasites when it occurs in portions of the genome that do not code for the essential features of complex adaptations. In this case heterozygosity can create a hostile microenvironment for parasites without disrupting adaptation. Facial bilateral symmetry is hypothesized to affect positive beauty judgments because symmetry is a certification of overall phenotypic quality and developmental health, which may be importantly influenced by parasites. Certain secondary sexual traits are influenced by testosterone, a hormone that reduces immunocompetence. Symmetry and size of the secondary sexual traits of the face (e.g., cheek bones) are expected to correlate positively and advertise immunocompetence honestly and therefore to affect positive beauty judgments. Facial attractiveness is predicted to correlate with attractive, nonfacial secondary sexual traits; other predictions from the view that parasite-driven selection led to the evolution of psychological adaptations of human beauty perception are discussed. The view that human physical attractiveness and judgments about human physical attractiveness evolved in the context of parasite-driven selection leads to the hypothesis that both adults and children have a species-typical adaptation to the problem of identifying and favoring healthy individuals and avoiding parasite

  15. Nanoscale particle therapies for wounds and ulcers.

    PubMed

    Cortivo, Roberta; Vindigni, Vincenzo; Iacobellis, Laura; Abatangelo, Giovanni; Pinton, Paolo; Zavan, Barbara

    2010-06-01

    'Small is beautiful' - this should be the slogan of nanoscientists. Indeed, working with particles less than 100 nm in size, nanotechnology is on the verge of providing a host of new materials and approaches, revolutionizing applied medicine. The obvious potential of nanotechnology has attracted considerable investment from governments and industry hoping to drive its economic development. Several areas of medical care already benefit from the advantages that nanotechnology provides and its application in wound healing will be reviewed in this article. PMID:20528458

  16. Beauty school, former executive settle suit alleging harassment.

    PubMed

    1996-02-01

    The [name removed] School of Beauty Culture in suburban Philadelphia settled a lawsuit filed by [name removed], former controller of the school. The suit claimed that the school had a policy of harassing and forcing out employees who might present a high risk for health-care costs, such as gay men who might develop HIV/AIDS. [Name removed] charged that the school violated the Americans with Disabilities Act (ADA) and the Federal Rehabilitation Act by targeting him for harassment after he revealed that he had a brain tumor. The terms of the settlement are confidential. PMID:11363166

  17. 3 mm can save your case: Making beauty function.

    PubMed

    Ratcliff, Steve; Brady, Lee Ann

    2011-01-01

    Understanding esthetic design is not enough if restorations are to withstand the forces of function. Dentists also must understand the relationships of incisal tables, the interincisal angle, disclusion forces, and the implications of changing those parameters when restoring the anterior dentition. While canine-protected occlusion is often a goal, it may not always be appropriate or attainable. This article describes the details of creating a functional anterior design that will not only be beautiful but will have the best chance of withstanding parafunctional activity and abnormal force. PMID:22313914

  18. Shaping the Female Student: An Analysis of Swedish Beauty School Recruitment Texts

    ERIC Educational Resources Information Center

    Bredlöv, Eleonor

    2016-01-01

    This study focuses on the recruitment of adults to the beauty industry in Sweden. It is concerned with a move in (beauty) education away from state and towards private provision in a wider context where education is becoming more heavily marketised. Drawing on a poststructural approach inspired by the work of Foucault and feminist theory, the…

  19. "An Option for Art But Not an Option for Life": Beauty as an Educational Imperative

    ERIC Educational Resources Information Center

    Winston, Joe

    2008-01-01

    This article proposes that beauty deserves to become an area of key interest to educationalists. The article begins by examining the reasons for the neglect of beauty in educational discourse before proposing how it might regain its influence as an educational concept by re-addressing the Platonic tradition and, in particular, by finding its…

  20. 76 FR 77582 - Culturally Significant Objects Imported for Exhibition Determinations: “Beauty and Belief...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Beauty and Belief: Crossing Bridges... April 15, 2003), I hereby determine that the objects to be included in the exhibition ``Beauty...

  1. The Beauty of the Psyche and Eros Myth: Integrating Aesthetics into Introduction to Psychology

    ERIC Educational Resources Information Center

    Diessner, Rhett; Burke, Kayla

    2011-01-01

    Beginning in the late 1990s the authors became convinced that their undergraduate psychology students needed classroom experiences that set the conditions for them to become more engaged with beauty. They recognized the intrinsic importance of beauty to human psychological development, beyond any utilitarian concerns. But they also believed that…

  2. Creating a Beautiful Mess: Ten Essential Play Experiences for a Joyous Childhood

    ERIC Educational Resources Information Center

    Gadzikowski, Ann

    2015-01-01

    When children play, they often create a mess, but what a beautiful mess it is! "Creating a Beautiful Mess" describes the ten most important play experiences all children enjoy and how these experiences support learning, creativity, and social connections. These broad categories of play include building with blocks, pretending and make…

  3. 76 FR 17485 - Pricing for America the Beautiful Five Ounce Silver Bullion Coin Presentation Case

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY United States Mint Pricing for America the Beautiful Five Ounce Silver Bullion Coin Presentation Case... is announcing the price of the America the Beautiful Five Ounce Silver Bullion Coin Presentation...

  4. 75 FR 10345 - Pricing for 2010 United States Mint America the Beautiful Quarters Proof Set, etc.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-05

    ...; 2010 United States Mint America the Beautiful Quarters Silver Proof Set; 2010 United States Mint Uncirculated Coin Set; 2010 United States Mint Proof Set; and 2010 United States Mint Silver Proof Set. The... United States Mint America the Beautiful Quarters Silver Proof Set will be priced at $32.95. The...

  5. The Contribution of Scenic Beauty Indicators in Estimating Environmental Welfare Measures: A Case Study

    ERIC Educational Resources Information Center

    Fanariotu, Ioanna; Skuras, Dimitris

    2004-01-01

    Aesthetic indicators of landscapes, expressed as individual scenic beauty estimates, may be used as proxies of individuals' specific aesthetic values, and improve the properties of welfare estimates produced by contingent valuation models. This work presents results from an interdisciplinary study where forest scenic beauty indicators are utilized…

  6. Beauty Culture: A Teacher's Guide to an Employment Orientation Course for Special Needs Students.

    ERIC Educational Resources Information Center

    Grubb, Francine

    This teacher's guide on beauty culture is one of a series of six designed for the employment orientation program for special needs students at the Gloucester County Vocational-Technical School in Sewell, New Jersey. The series includes laundry, hospitality, sewing, basic business, food, and beauty culture. Each guide contains lesson plans…

  7. A twentieth-century triangle trade: selling black beauty at home and abroad, 1945–1965.

    PubMed

    McAndrew, Malia

    2010-01-01

    This study examines the careers of African American beauty culturists as they worked in the United States, Europe, and Africa between 1945 and 1965. Facing push back at home, African American beauty entrepreneurs frequently sought out international venues that were hospitable and receptive to black Americans in the years following World War II. By strategically using European sites that white Americans regarded as the birthplace of Western fashion and beauty, African American entrepreneurs in the fields of modeling, fashion design, and hair care were able to win accolades and advance their careers. In gaining support abroad, particularly in Europe, these beauty culturists capitalized on their international success to establish, legitimize, and promote their business ventures in the United States. After importing a positive reputation for themselves from Europe to the United States, African American beauty entrepreneurs then exported an image of themselves as the world's premier authorities on black beauty to people of color around the globe as they sold their products and marketed their expertise on the African continent itself. This essay demonstrates the important role that these black female beauty culturists played, both as businesspeople and as race leaders, in their generation's struggle to gain greater respect and opportunity for African Americans both at home and abroad. In doing so it places African American beauty culturists within the framework of transatlantic trade networks, the Black Freedom Movement, Pan-Africanism, and America's Cold War struggle. PMID:21114069

  8. 77 FR 56251 - Culturally Significant Objects Imported for Exhibition Determinations: “The Body Beautiful in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``The Body Beautiful in Ancient Greece... determine that the objects to be included in the exhibition ``The Body Beautiful in Ancient...

  9. 76 FR 15047 - Pricing for 2010 United States Mint America the Beautiful Quarters Silver Proof SetTM

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-18

    ... United States Mint Pricing for 2010 United States Mint America the Beautiful Quarters Silver Proof Set\\TM\\, etc. ACTION: Pricing for 2010 United States Mint America the Beautiful Quarters Silver Proof Set TM ; 2010 United States Mint Silver Proof Set TM ; 2011 United States Mint America the Beautiful...

  10. 77 FR 840 - Pricing for 2012 America the Beautiful Quarters® Products and American Eagle Silver Dollars

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-06

    ... United States Mint Pricing for 2012 America the Beautiful Quarters Products and American Eagle Silver... Mint is announcing 2012 pricing for America the Beautiful Quarters products and American Eagle Silver... Quarters Circulating Coin Set TM..... 5.95 America the Beautiful Five Ounce Silver Uncirculated Coin.....

  11. A tevatron collider beauty factory. [Final report, 1980--1992

    SciTech Connect

    Not Available

    1992-12-31

    This document which is labeled a final report consists of several different items. The first is a proposal for a detector to be developed for beauty physics. The detector is proposed for the Fermilab Tevatron, and would be designed to measure mixing reactions, rare decay modes, and even CP violation in hadron collider beauty production. The general outline of the work proposed is given, and an estimate of the time to actually design the detector is presented, along with proposed changes to the Tevatron to accommodate the system. A preliminary report on an experiment to verify a reported observation of a 17 keV neutrino in tritium decay is presented. The present results in the decay spectra actually show a depression below expected levels, which is not consistent with a massive neutrino. Additional interest has been shown in finishing an electrostatic beta spectrometer which was started several years previously. The instrument uses hemispherical electrostatic electric fields to retard electrons emitted in tritium decay, allowing measurement of integral spectra. The design goal has a 5 eV energy resolution, which may be achievable. A new PhD student is pursuing this experiment. Also the report contains a proposal for additional work in the field of non-perturbative quantum field theory by the theoretical group at OU. The work which is proposed will be applied to electroweak and strong interactions, as well as to quantum gravitational phenomena.

  12. Living donor kidney transplantation: "beauty and the beast"!

    PubMed

    Danovitch, Gabriel M

    2013-01-01

    The report by Terasaki and colleagues in 1995 that the outcomes of spousal and biologically unrelated transplants were essentially the same as for 1-haplotype matched living related transplants changed the course of clinical transplantation. This article, entitled metaphorically "Beauty and the Beast", describes the dramatic change in the practice of living donor transplantation that followed. In the ensuing two decades, biologically unrelated living donor transplantation became commonplace in the developed world and reached its apotheosis in cross-country living donor paired exchange programs that have made transplantation accessible to many whose donors were deemed "incompatible". Such exchanges can indeed be thought of as a "thing of beauty". Sadly, the same observation was abused to exploit vulnerable donors, and the "beast" in the form of transplant tourism became a feature of transplantation in the developing world. The responsibility of the transplant community to protect the welfare of living donors and their recipients and the key role of trust in the evaluation of living donors is discussed. PMID:25095511

  13. Decay Constants of Beauty Mesons from QCD Sum Rules

    NASA Astrophysics Data System (ADS)

    Lucha, Wolfgang; Melikhov, Dmitri; Simula, Silvano

    2014-11-01

    Our recently completed analysis of the decay constants of both pseudoscalar and vector beauty mesons reveals that in the bottom-quark sector two specific features of the sum-rule predictions show up: (i) For the input value of the bottom-quark mass in the M̅S̅ scheme m̅b(m̅b) ≈ 4:18 GeV; the sum-rule result fB ≈ 210-220 MeV for the B meson decay constant is substantially larger than the recent lattice-QCD finding fB ≈ 190 MeV: Requiring QCD sum rules to reproduce the lattice-QCD value of fB yields a significantly larger b-quark mass: m̅b(m̅b) = 4:247 GeV: (ii) Whereas QCD sum-rule predictions for the charmed-meson decay constants fD; fDs, fD* and fDs* are practically independent of the choice of renormalization scale, in the beauty sector the results for the decay constants—and especially for the ratio fB* / fB—prove to be very sensitive to the specific scale setting.

  14. Hidden-beauty charged tetraquarks and heavy quark spin conservation

    NASA Astrophysics Data System (ADS)

    Ali, A.; Maiani, L.; Polosa, A. D.; Riquer, V.

    2015-01-01

    Assuming the dominance of the spin-spin interaction in a diquark, we point out that the mass difference in the beauty sector M (Zb')±-M (Zb)± scales with quark masses as expected in QCD, with respect to the corresponding mass difference M (Zc')±-M (Zc)± . Notably, we show that the decays ϒ (10890 )→ϒ (n S )π+π- and ϒ (10890 )→(hb(1 P ),hb(2 P ))π+π- are compatible with heavy quark spin conservation if the contributions of Zb,Zb' intermediate states are taken into account, ϒ (10890 ) being either a ϒ (5 S ) or the beauty analog of Yc(4260 ). Belle results on these decays support the quark spin wave function of the Z states as tetraquarks. We also consider the role of light quark spin nonconservaton in Zb,Zb' decays into B B* and B*B*. Indications of possible signatures of the still missing Xb resonance are proposed.

  15. Eyes of beautiful women and femme fatales depicted in Western portraits.

    PubMed

    Hwang, Kun; Hong, Jung Ui; Park, Sung Jun; Hwang, Se Won

    2015-05-01

    This study aimed to compare the eyes of beautiful women and femme fatales depicted in Western portraits. A total of 37 samples were collected; 19 beautiful women and 18 femme fatales. Nine aspects were measured in reference to the corneal horizontal diameter. The estimated corneal vertical diameter was calculated by a corneal horizontal diameter multiply constant, 1.11.The double-fold was observed in 89% (17 of 19) of the beautiful women and 83% (15 of 18) of the femme fatales. The eye-width ratio was 2.42 (SD, 0.28) in the beautiful women and 2.31 (SD, 0.34) in the femme fatales. The eye-height ratio was 0.91 (SD, 0.18) in the beautiful women and 0.84 (SD, 0.10) in the femme fatales. Eyebrow-to-upper lid distance was 0.92 (SD, 0.35) in the beautiful women and 0.89 (SD, 0.23) in the femme fatales. The interpupillary distance was 5.00 (SD, 0.46) in the beautiful women and 5.00 (SD, 0.71) in the femme fatales. The intercanthal distance was 2.72 (SD, 0.42) in the beautiful women and 2.78 (SD, 0.73) in the femme fatales The outer canthal distance was 7.32 (SD, 0.64) in the beautiful women and 7.20 (SD, 1.01) in the femme fatales. The ptosis amount was -0.01 (SD, 0.18) in the beautiful women and 0.06 (SD, 0.01) in the femme fatales. For the above 7 measurements, there were no significant differences between the 2 groups (P > 0.05, t test).It is noteworthy that the beautiful women and femme fatales have the same interpupillary distance (5.00). Also, the ptosis ratio was almost zero in both groups (-0.01 [SD, 0.18] in the beautiful women and 0.06 [SD, 0.01] in the femme fatales). The results of this study might be of some reference in performing eyelid surgeries especially in brow lifts or canthoplasties. PMID:25974803

  16. Measurement of charm and beauty photoproduction at HERA using D* μ correlations

    NASA Astrophysics Data System (ADS)

    Aktas, A.; Andreev, V.; Anthonis, T.; Aplin, S.; Asmone, A.; Astvatsatourov, A.; Babaev, A.; Backovic, S.; Bähr, J.; Baghdasaryan, A.; Baranov, P.; Barrelet, E.; Bartel, W.; Baudrand, S.; Baumgartner, S.; Becker, J.; Beckingham, M.; Behnke, O.; Behrendt, O.; Belousov, A.; Berger, Ch.; Berger, N.; Bizot, J. C.; Boenig, M.-O.; Boudry, V.; Bracinik, J.; Brandt, G.; Brisson, V.; Brown, D. P.; Bruncko, D.; Büsser, F. W.; Bunyatyan, A.; Buschhorn, G.; Bystritskaya, L.; Campbell, A. J.; Caron, S.; Cassol-Brunner, F.; Cerny, K.; Cerny, V.; Chekelian, V.; Contreras, J. G.; Coughlan, J. A.; Cox, B. E.; Cozzika, G.; Cvach, J.; Dainton, J. B.; Dau, W. D.; Daum, K.; Delcourt, B.; Demirchyan, R.; De Roeck, A.; Desch, K.; De Wolf, E. A.; Diaconu, C.; Dodonov, V.; Dubak, A.; Eckerlin, G.; Efremenko, V.; Egli, S.; Eichler, R.; Eisele, F.; Ellerbrock, M.; Elsen, E.; Erdmann, W.; Essenov, S.; Falkewicz, A.; Faulkner, P. J. W.; Favart, L.; Fedotov, A.; Felst, R.; Ferencei, J.; Finke, L.; Fleischer, M.; Fleischmann, P.; Fleming, Y. H.; Flucke, G.; Fomenko, A.; Foresti, I.; Formánek, J.; Franke, G.; Frising, G.; Frisson, T.; Gabathuler, E.; Garutti, E.; Gayler, J.; Gerhards, R.; Gerlich, C.; Ghazaryan, S.; Ginzburgskaya, S.; Glazov, A.; Glushkov, I.; Goerlich, L.; Goettlich, M.; Gogitidze, N.; Gorbounov, S.; Goyon, C.; Grab, C.; Greenshaw, T.; Gregori, M.; Grindhammer, G.; Gwilliam, C.; Haidt, D.; Hajduk, L.; Haller, J.; Hansson, M.; Heinzelmann, G.; Henderson, R. C. W.; Henschel, H.; Henshaw, O.; Herrera, G.; Hildebrandt, M.; Hiller, K. H.; Hoffmann, D.; Horisberger, R.; Hovhannisyan, A.; Ibbotson, M.; Ismail, M.; Jacquet, M.; Janauschek, L.; Janssen, X.; Jemanov, V.; Jönsson, L.; Johnson, D. P.; Jung, H.; Kapichine, M.; Karlsson, M.; Katzy, J.; Keller, N.; Kenyon, I. R.; Kiesling, C.; Klein, M.; Kleinwort, C.; Klimkovich, T.; Kluge, T.; Knies, G.; Knutsson, A.; Korbel, V.; Kostka, P.; Koutouev, R.; Krastev, K.; Kretzschmar, J.; Kropivnitskaya, A.; Krüger, K.; Kückens, J.; Landon, M. P. J.; Lange, W.; Laštovička, T.; Laycock, P.; Lebedev, A.; Leißner, B.; Lendermann, V.; Levonian, S.; Lindfeld, L.; Lipka, K.; List, B.; Lobodzinska, E.; Loktionova, N.; Lopez-Fernandez, R.; Lubimov, V.; Lucaci-Timoce, A.-I.; Lueders, H.; Lüke, D.; Lux, T.; Lytkin, L.; Makankine, A.; Malden, N.; Malinovski, E.; Mangano, S.; Marage, P.; Marshall, R.; Martisikova, M.; Martyn, H.-U.; Maxfield, S. J.; Meer, D.; Mehta, A.; Meier, K.; Meyer, A. B.; Meyer, H.; Meyer, J.; Mikocki, S.; Milcewicz-Mika, I.; Milstead, D.; Mohamed, A.; Moreau, F.; Morozov, A.; Morris, J. V.; Mozer, M. U.; Müller, K.; Murín, P.; Nankov, K.; Naroska, B.; Naumann, J.; Naumann, Th.; Newman, P. R.; Niebuhr, C.; Nikiforov, A.; Nikitin, D.; Nowak, G.; Nozicka, M.; Oganezov, R.; Olivier, B.; Olsson, J. E.; Osman, S.; Ozerov, D.; Palichik, V.; Papadopoulou, T.; Pascaud, C.; Patel, G. D.; Peez, M.; Perez, E.; Perez-Astudillo, D.; Perieanu, A.; Petrukhin, A.; Pitzl, D.; Plačakytė, R.; Portheault, B.; Povh, B.; Prideaux, P.; Raicevic, N.; Reimer, P.; Rimmer, A.; Risler, C.; Rizvi, E.; Robmann, P.; Roland, B.; Roosen, R.; Rostovtsev, A.; Rurikova, Z.; Rusakov, S.; Salvaire, F.; Sankey, D. P. C.; Sauvan, E.; Schätzel, S.; Schilling, F.-P.; Schmidt, S.; Schmitt, S.; Schmitz, C.; Schoeffel, L.; Schöning, A.; Schröder, V.; Schultz-Coulon, H.-C.; Schwanenberger, C.; Sedlák, K.; Sefkow, F.; Sheviakov, I.; Shtarkov, L. N.; Sirois, Y.; Sloan, T.; Smirnov, P.; Soloviev, Y.; South, D.; Spaskov, V.; Specka, A.; Stella, B.; Stiewe, J.; Strauch, I.; Straumann, U.; Tchoulakov, V.; Thompson, G.; Thompson, P. D.; Tomasz, F.; Traynor, D.; Truöl, P.; Tsakov, I.; Tsipolitis, G.; Tsurin, I.; Turnau, J.; Tzamariudaki, E.; Urban, M.; Usik, A.; Utkin, D.; Valkár, S.; Valkárová, A.; Vallée, C.; Van Mechelen, P.; Van Remortel, N.; Vargas Trevino, A.; Vazdik, Y.; Veelken, C.; Vest, A.; Vinokurova, S.; Volchinski, V.; Vujicic, B.; Wacker, K.; Wagner, J.; Weber, G.; Weber, R.; Wegener, D.; Werner, C.; Werner, N.; Wessels, M.; Wessling, B.; Wigmore, C.; Winter, G.-G.; Wissing, Ch.; Wolf, R.; Wünsch, E.; Xella, S.; Yan, W.; Yeganov, V.; Žáček, J.; Zálešák, J.; Zhang, Z.; Zhelezov, A.; Zhokin, A.; Zimmermann, J.; Zohrabyan, H.; Zomer, F.; H1 Collaboration

    2005-08-01

    A measurement of charm and beauty photoproduction at the electron proton collider HERA is presented based on the simultaneous detection of a D*± meson and a muon. The correlation between the D* meson and the muon serves to separate the charm and beauty contributions and the analysis provides comparable sensitivity to both. The total and differential experimental cross sections are compared to LO and NLO QCD calculations. The measured charm cross section is in good agreement with QCD predictions including higher order effects while the beauty cross section is higher.

  17. Measurement of charm and beauty photoproduction at HERA using Dμ correlations

    NASA Astrophysics Data System (ADS)

    H1 Collaboration; Aktas, A.; Andreev, V.; Anthonis, T.; Aplin, S.; Asmone, A.; Astvatsatourov, A.; Babaev, A.; Backovic, S.; Bähr, J.; Baghdasaryan, A.; Baranov, P.; Barrelet, E.; Bartel, W.; Baudrand, S.; Baumgartner, S.; Becker, J.; Beckingham, M.; Behnke, O.; Behrendt, O.; Belousov, A.; Berger, Ch.; Berger, N.; Bizot, J. C.; Boenig, M.-O.; Boudry, V.; Bracinik, J.; Brandt, G.; Brisson, V.; Brown, D. P.; Bruncko, D.; Büsser, F. W.; Bunyatyan, A.; Buschhorn, G.; Bystritskaya, L.; Campbell, A. J.; Caron, S.; Cassol-Brunner, F.; Cerny, K.; Cerny, V.; Chekelian, V.; Contreras, J. G.; Coughlan, J. A.; Cox, B. E.; Cozzika, G.; Cvach, J.; Dainton, J. B.; Dau, W. D.; Daum, K.; Delcourt, B.; Demirchyan, R.; de Roeck, A.; Desch, K.; de Wolf, E. A.; Diaconu, C.; Dodonov, V.; Dubak, A.; Eckerlin, G.; Efremenko, V.; Egli, S.; Eichler, R.; Eisele, F.; Ellerbrock, M.; Elsen, E.; Erdmann, W.; Essenov, S.; Falkewicz, A.; Faulkner, P. J. W.; Favart, L.; Fedotov, A.; Felst, R.; Ferencei, J.; Finke, L.; Fleischer, M.; Fleischmann, P.; Fleming, Y. H.; Flucke, G.; Fomenko, A.; Foresti, I.; Formánek, J.; Franke, G.; Frising, G.; Frisson, T.; Gabathuler, E.; Garutti, E.; Gayler, J.; Gerhards, R.; Gerlich, C.; Ghazaryan, S.; Ginzburgskaya, S.; Glazov, A.; Glushkov, I.; Goerlich, L.; Goettlich, M.; Gogitidze, N.; Gorbounov, S.; Goyon, C.; Grab, C.; Greenshaw, T.; Gregori, M.; Grindhammer, G.; Gwilliam, C.; Haidt, D.; Hajduk, L.; Haller, J.; Hansson, M.; Heinzelmann, G.; Henderson, R. C. W.; Henschel, H.; Henshaw, O.; Herrera, G.; Hildebrandt, M.; Hiller, K. H.; Hoffmann, D.; Horisberger, R.; Hovhannisyan, A.; Ibbotson, M.; Ismail, M.; Jacquet, M.; Janauschek, L.; Janssen, X.; Jemanov, V.; Jönsson, L.; Johnson, D. P.; Jung, H.; Kapichine, M.; Karlsson, M.; Katzy, J.; Keller, N.; Kenyon, I. R.; Kiesling, C.; Klein, M.; Kleinwort, C.; Klimkovich, T.; Kluge, T.; Knies, G.; Knutsson, A.; Korbel, V.; Kostka, P.; Koutouev, R.; Krastev, K.; Kretzschmar, J.; Kropivnitskaya, A.; Krüger, K.; Kückens, J.; Landon, M. P. J.; Lange, W.; Laštovička, T.; Laycock, P.; Lebedev, A.; Leißner, B.; Lendermann, V.; Levonian, S.; Lindfeld, L.; Lipka, K.; List, B.; Lobodzinska, E.; Loktionova, N.; Lopez-Fernandez, R.; Lubimov, V.; Lucaci-Timoce, A.-I.; Lueders, H.; Lüke, D.; Lux, T.; Lytkin, L.; Makankine, A.; Malden, N.; Malinovski, E.; Mangano, S.; Marage, P.; Marshall, R.; Martisikova, M.; Martyn, H.-U.; Maxfield, S. J.; Meer, D.; Mehta, A.; Meier, K.; Meyer, A. B.; Meyer, H.; Meyer, J.; Mikocki, S.; Milcewicz-Mika, I.; Milstead, D.; Mohamed, A.; Moreau, F.; Morozov, A.; Morris, J. V.; Mozer, M. U.; Müller, K.; Murín, P.; Nankov, K.; Naroska, B.; Naumann, J.; Naumann, Th.; Newman, P. R.; Niebuhr, C.; Nikiforov, A.; Nikitin, D.; Nowak, G.; Nozicka, M.; Oganezov, R.; Olivier, B.; Olsson, J. E.; Osman, S.; Ozerov, D.; Palichik, V.; Papadopoulou, T.; Pascaud, C.; Patel, G. D.; Peez, M.; Perez, E.; Perez-Astudillo, D.; Perieanu, A.; Petrukhin, A.; Pitzl, D.; Plačakytė, R.; Portheault, B.; Povh, B.; Prideaux, P.; Raicevic, N.; Reimer, P.; Rimmer, A.; Risler, C.; Rizvi, E.; Robmann, P.; Roland, B.; Roosen, R.; Rostovtsev, A.; Rurikova, Z.; Rusakov, S.; Salvaire, F.; Sankey, D. P. C.; Sauvan, E.; Schätzel, S.; Schilling, F.-P.; Schmidt, S.; Schmitt, S.; Schmitz, C.; Schoeffel, L.; Schöning, A.; Schröder, V.; Schultz-Coulon, H.-C.; Schwanenberger, C.; Sedlák, K.; Sefkow, F.; Sheviakov, I.; Shtarkov, L. N.; Sirois, Y.; Sloan, T.; Smirnov, P.; Soloviev, Y.; South, D.; Spaskov, V.; Specka, A.; Stella, B.; Stiewe, J.; Strauch, I.; Straumann, U.; Tchoulakov, V.; Thompson, G.; Thompson, P. D.; Tomasz, F.; Traynor, D.; Truöl, P.; Tsakov, I.; Tsipolitis, G.; Tsurin, I.; Turnau, J.; Tzamariudaki, E.; Urban, M.; Usik, A.; Utkin, D.; Valkár, S.; Valkárová, A.; Vallée, C.; van Mechelen, P.; van Remortel, N.; Vargas Trevino, A.; Vazdik, Y.; Veelken, C.; Vest, A.; Vinokurova, S.; Volchinski, V.; Vujicic, B.; Wacker, K.; Wagner, J.; Weber, G.; Weber, R.; Wegener, D.; Werner, C.; Werner, N.; Wessels, M.; Wessling, B.; Wigmore, C.; Winter, G.-G.; Wissing, Ch.; Wolf, R.; Wünsch, E.; Xella, S.; Yan, W.; Yeganov, V.; Žáček, J.; Zálešák, J.; Zhang, Z.; Zhelezov, A.; Zhokin, A.; Zimmermann, J.; Zohrabyan, H.; Zomer, F.

    2005-08-01

    A measurement of charm and beauty photoproduction at the electron proton collider HERA is presented based on the simultaneous detection of a D meson and a muon. The correlation between the D meson and the muon serves to separate the charm and beauty contributions and the analysis provides comparable sensitivity to both. The total and differential experimental cross sections are compared to LO and NLO QCD calculations. The measured charm cross section is in good agreement with QCD predictions including higher order effects while the beauty cross section is higher.

  18. Feasibility of Utilizing Ethnic Beauty Salons for Cervical Cancer Screening Education.

    PubMed

    Lee, Jongwon; Carvallo, Mauricio; Lee, Eunice

    2015-11-01

    The purpose of this study was to assess the feasibility of using ethnic beauty salons to reach out to Vietnamese and Korean American women for cervical cancer screening education. Participants (N = 62) were conveniently recruited from ethnic beauty salons located in Albuquerque, New Mexico. Two feasibility questionnaires were separately administered to cosmetologists and their customers. Findings support the view that ethnic beauty salons can be used as a gateway to reach out to these populations, and cosmetologists have the potential to operate as community lay health workers to deliver cervical cancer screening education aimed at reducing disparities in cervical cancer and screening to their ethnic customers. PMID:24698810

  19. Childhood beauty pageant contestants: associations with adult disordered eating and mental health.

    PubMed

    Wonderlich, Anna L; Ackard, Diann M; Henderson, Judith B

    2005-01-01

    This study evaluated the association between childhood beauty pageants and adult disordered eating, body dissatisfaction, depression, and self-esteem. Eleven women who participated in childhood beauty pageants were matched on age and BMI with 11 non-participating women. Childhood pageant participants scored higher on body dissatisfaction, interpersonal distrust, and impulse dysregulation than non-participants, and showed a trend toward greater ineffectiveness. There were no significant differences between groups on measures of bulimia, body perception, depression, and self-esteem. These findings suggest childhood beauty pageant participation may influence adult body dissatisfaction, interpersonal distrust, and impulse dysregulation, but not bulimic behaviors, body perception, depression, and self-esteem. PMID:16864534

  20. The culture of complexion: the impacts of society's role in shaping the definition of beauty.

    PubMed

    Carlock, Sarah; Russell, Brian

    2015-05-01

    The definition of beauty has evolved as the trends valued by the top of society change. For centuries, fair skin was a requirement of the Western definition of beauty; however, a shift in the 1920s made tanned skin the new standard. In this article, smoking and tanning are presented as risky behaviors that are perpetuated through industry advertising and exploitation of the authority of health professionals. The article further explores the culture of complexion in Western society before and after the 1920s as well as the consequences of tanning and efforts to rewrite society's definition of beauty. PMID:25966601

  1. Modeling Regulatory Networks to Understand Plant Development: Small Is Beautiful

    PubMed Central

    Middleton, Alistair M.; Farcot, Etienne; Owen, Markus R.; Vernoux, Teva

    2012-01-01

    We now have unprecedented capability to generate large data sets on the myriad genes and molecular players that regulate plant development. Networks of interactions between systems components can be derived from that data in various ways and can be used to develop mathematical models of various degrees of sophistication. Here, we discuss why, in many cases, it is productive to focus on small networks. We provide a brief and accessible introduction to relevant mathematical and computational approaches to model regulatory networks and discuss examples of small network models that have helped generate new insights into plant biology (where small is beautiful), such as in circadian rhythms, hormone signaling, and tissue patterning. We conclude by outlining some of the key technical and modeling challenges for the future. PMID:23110896

  2. Beautiful Math, Part 5: Colorful Archimedean Tilings from Dynamical Systems.

    PubMed

    Ouyang, Peichang; Zhao, Weiguo; Huang, Xuan

    2015-01-01

    The art of tiling originated very early in the history of civilization. Almost every known human society has made use of tilings in some form or another. In particular, tilings using only regular polygons have great visual appeal. Decorated regular tilings with continuous and symmetrical patterns were widely used in decoration field, such as mosaics, pavements, and brick walls. In science, these tilings provide inspiration for synthetic organic chemistry. Building on previous CG&A “Beautiful Math” articles, the authors propose an invariant mapping method to create colorful patterns on Archimedean tilings (1-uniform tilings). The resulting patterns simultaneously have global crystallographic symmetry and local cyclic or dihedral symmetry. PMID:26594960

  3. Test of principle of an optical trigger for beauty

    NASA Astrophysics Data System (ADS)

    Kaplan, D. M.; Apolinski, M.; Luebke, W.; Kwan, S. W. L.

    1993-06-01

    We have carried out a test of the principle of the Optical Trigger for Beauty proposed by Charpak, Giomataris, and Lederman. We measure the production and trapping by total internal reflection of Cherenkov light produced in a flat crystal of MgF 2 by the passage of high-energy muons. Using an array of drift tubes to measure the trajectories of the muons, we observe a threshold in the production of trapped Cherenkov light as a function of muon incident angle. The shape of the threshold curve is consistent with that expected from a simple optical calculation. An angle-independent component of trapped Cherenkov light, apparently due to delta rays, is also observed. We discuss prospects for a practical device.

  4. Deep and beautiful. The reward prediction error hypothesis of dopamine.

    PubMed

    Colombo, Matteo

    2014-03-01

    According to the reward-prediction error hypothesis (RPEH) of dopamine, the phasic activity of dopaminergic neurons in the midbrain signals a discrepancy between the predicted and currently experienced reward of a particular event. It can be claimed that this hypothesis is deep, elegant and beautiful, representing one of the largest successes of computational neuroscience. This paper examines this claim, making two contributions to existing literature. First, it draws a comprehensive historical account of the main steps that led to the formulation and subsequent success of the RPEH. Second, in light of this historical account, it explains in which sense the RPEH is explanatory and under which conditions it can be justifiably deemed deeper than the incentive salience hypothesis of dopamine, which is arguably the most prominent contemporary alternative to the RPEH. PMID:24252364

  5. Modeling regulatory networks to understand plant development: small is beautiful.

    PubMed

    Middleton, Alistair M; Farcot, Etienne; Owen, Markus R; Vernoux, Teva

    2012-10-01

    We now have unprecedented capability to generate large data sets on the myriad genes and molecular players that regulate plant development. Networks of interactions between systems components can be derived from that data in various ways and can be used to develop mathematical models of various degrees of sophistication. Here, we discuss why, in many cases, it is productive to focus on small networks. We provide a brief and accessible introduction to relevant mathematical and computational approaches to model regulatory networks and discuss examples of small network models that have helped generate new insights into plant biology (where small is beautiful), such as in circadian rhythms, hormone signaling, and tissue patterning. We conclude by outlining some of the key technical and modeling challenges for the future. PMID:23110896

  6. Identification of beauty and charm quark jets at LHCb

    NASA Astrophysics Data System (ADS)

    The LHCb Collaboration

    2015-06-01

    Identification of jets originating from beauty and charm quarks is important for measuring Standard Model processes and for searching for new physics. The performance of algorithms developed to select b- and c-quark jets is measured using data recorded by LHCb from proton-proton collisions at √s = 7 TeV in 2011 and at √s = 8 TeV in 2012. The efficiency for identifying a b(c) jet is about 65%(25%) with a probability for misidentifying a light-parton jet of 0.3% for jets with transverse momentum pT > 20GeV and pseudorapidity 2.2 < η < 4.2. The dependence of the performance on the pT and η of the jet is also measured.

  7. Flavour physics and the Large Hadron Collider beauty experiment.

    PubMed

    Gibson, Valerie

    2012-02-28

    An exciting new era in flavour physics has just begun with the start of the Large Hadron Collider (LHC). The LHCb (where b stands for beauty) experiment, designed specifically to search for new phenomena in quantum loop processes and to provide a deeper understanding of matter-antimatter asymmetries at the most fundamental level, is producing many new and exciting results. It gives me great pleasure to describe a selected few of the results here-in particular, the search for rare B(0)(s)-->μ+ μ- decays and the measurement of the B(0)(s) charge-conjugation parity-violating phase, both of which offer high potential for the discovery of new physics at and beyond the LHC energy frontier in the very near future. PMID:22253243

  8. Rhinoplasty and its effects on the perception of beauty

    PubMed Central

    Chinski, Hernan; Chinski, Luis; Armijos, Jenny; Arias, Juan Pablo

    2013-01-01

    Summary Introduction: Experts on nasal cosmetics and nasal surgery agree that aesthetic rhinoplasty leads to overall facial beautification and the perception of youth in patients. This “assumed truth” has never been proven in the international literature. Aim: To examine increases in facial attractiveness ratings after rhinoplasty surgery. Methods: We conducted a study series by choosing 30 female patients on whom we had operated and 25 evaluators in a single blind trial. The evaluators graded the patients' attractiveness before and after surgery. Results: Beauty indices were significantly improved after the operation. Conclusion: According to the third-party evaluation, the patients appeared prettier after undergoing aesthetic rhinoplasty. PMID:25991993

  9. Recurrent encephalopathy? No I'm a sleeping beauty!

    PubMed

    Iqbal, Mehtab; Prasad, Manish; Ritey, Christopher

    2014-01-01

    To describe the clinical presentation of 'Kleine-Levin (sleeping beauty) syndrome' in a child, who presented with recurrent episodes consistent with encephalopathy, associated with excessive sleepiness, cognitive and behavioural disturbance and hyper sexuality. 14 years old boy presented acutely with excessive tiredness, sleeping excessively, abnormal behaviour and hypersexuality following a viral throat infection. On examination he was sleepy but easily arousable. His GCS (15/15) and rest of the neurological examination including fundoscopy and other systemic examination was completely unremarkable. All his initial investigations including electrolytes, LFTs, CSF, virology screen and MRI brain scan were normal. Detailed autoimmune screening was also negative. EEG showed non-specific diffuse slowing consistent with encephalopathy. His excessive sleepiness gradually improved together with his altered behaviour in about two weeks after presentation. Hyper sexuality became more overt during this phase. All these symptoms completely disappeared three weeks after his presentation and he attended school as before. He was readmitted six weeks later with exactly similar presentation and again only positive result being diffuse non-specific slowing of EEG. His recovery was also similar and he was completely back to his normal self in three weeks time. His recurrent symptoms were consistent with 'Kleine-Levin syndrome (KLS)' or 'sleeping beauty syndrome'. KLS is a rare disorder which mainly affects adolescent males. Common symptoms include hypersomnia (100%), cognitive changes (96%), eating disturbances (80%), hypersexuality, compulsions, and depressed mood. The syndrome usually lasts for 8 years, with on an average seven episode of 10 days each recurring every 3.5 months. It is most frequently precipitated by infections and somnolence decreases using stimulants in nearly 40% of cases. PMID:24891916

  10. Recurrent encephalopathy? No I’m a sleeping beauty!

    PubMed Central

    Iqbal, Mehtab; Prasad, Manish; Ritey, Christopher

    2014-01-01

    To describe the clinical presentation of ‘Kleine-Levin (sleeping beauty) syndrome’ in a child, who presented with recurrent episodes consistent with encephalopathy, associated with excessive sleepiness, cognitive and behavioural disturbance and hyper sexuality. 14 years old boy presented acutely with excessive tiredness, sleeping excessively, abnormal behaviour and hypersexuality following a viral throat infection. On examination he was sleepy but easily arousable. His GCS (15/15) and rest of the neurological examination including fundoscopy and other systemic examination was completely unremarkable. All his initial investigations including electrolytes, LFTs, CSF, virology screen and MRI brain scan were normal. Detailed autoimmune screening was also negative. EEG showed non-specific diffuse slowing consistent with encephalopathy. His excessive sleepiness gradually improved together with his altered behaviour in about two weeks after presentation. Hyper sexuality became more overt during this phase. All these symptoms completely disappeared three weeks after his presentation and he attended school as before. He was readmitted six weeks later with exactly similar presentation and again only positive result being diffuse non-specific slowing of EEG. His recovery was also similar and he was completely back to his normal self in three weeks time. His recurrent symptoms were consistent with ‘Kleine-Levin syndrome (KLS)’ or ‘sleeping beauty syndrome’. KLS is a rare disorder which mainly affects adolescent males. Common symptoms include hypersomnia (100%), cognitive changes (96%), eating disturbances (80%), hypersexuality, compulsions, and depressed mood. The syndrome usually lasts for 8 years, with on an average seven episode of 10 days each recurring every 3.5 months. It is most frequently precipitated by infections and somnolence decreases using stimulants in nearly 40% of cases. PMID:24891916

  11. 78 FR 55772 - Culturally Significant Object Imported for Exhibition Determinations: “Beauty Revealed: Images of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Object Imported for Exhibition Determinations: ``Beauty Revealed: Images of Women in...: Images of Women in Qing Dynasty Chinese Painting,'' imported from abroad for temporary exhibition...

  12. 75 FR 56506 - Beauty and Cosmetics Trade Mission to India; Application Deadline Extended and Acceptance To...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE International Trade Administration Beauty and Cosmetics Trade Mission to India; Application Deadline Extended and Acceptance To Participate Changed to First-Come First- Serve Basis AGENCY: International...

  13. The Realm of Fairy Story: J.R.R. Tolkien and Robin McKinley's "Beauty."

    ERIC Educational Resources Information Center

    Woolsey, Daniel P.

    1991-01-01

    Discusses the development of a modern fairy tale with respect to J.R.R. Tolkien's mapping of its features, terrain, and emotional geography. Discusses Robin McKinley's "Beauty," an example of a modern fantasy. (PRA)

  14. Stress and strategic decision-making in the beauty contest game.

    PubMed

    Leder, Johannes; Häusser, Jan Alexander; Mojzisch, Andreas

    2013-09-01

    Often, economic decisions do not only depend on one's own preferences, but also on the choices of others and therefore require strategizing (i.e., thinking about what others might think). In experimental economics, this has been modeled by the beauty contest game. Another typical feature of economic decisions is that they are often carried out under stress. Therefore, in the present study, we aimed to examine the influence of stress on decision-making in the beauty contest game. Participants were randomly assigned to either the Trier Social Stress Test for Groups (TSST-G) or a placebo version of the TSST-G (control condition). Then, participants played four rounds of a standard beauty contest game. As a biomarker of stress, salivary cortisol was measured. As predicted, participants under stress chose higher numbers in the beauty contest game than non-stressed participants, indicating less strategizing. This effect was mediated by the stress-induced increase in cortisol. PMID:23312062

  15. Automated classification of female facial beauty by image analysis and supervised learning

    NASA Astrophysics Data System (ADS)

    Gunes, Hatice; Piccardi, Massimo; Jan, Tony

    2004-01-01

    The fact that perception of facial beauty may be a universal concept has long been debated amongst psychologists and anthropologists. In this paper, we performed experiments to evaluate the extent of beauty universality by asking a number of diverse human referees to grade a same collection of female facial images. Results obtained show that the different individuals gave similar votes, thus well supporting the concept of beauty universality. We then trained an automated classifier using the human votes as the ground truth and used it to classify an independent test set of facial images. The high accuracy achieved proves that this classifier can be used as a general, automated tool for objective classification of female facial beauty. Potential applications exist in the entertainment industry and plastic surgery.

  16. Measurement of beauty production at HERA using events with muons and jets

    SciTech Connect

    Behnke, Olaf

    2005-10-06

    Several new measurements of beauty production at HERA have been presented at this conference. In this talk we report about the H1 measurement using events with a muon associated to a jet. This is the first beauty analysis at HERA, where both the long lifetime and the large mass of b-flavoured hadrons are exploited to identify the beauty events, leading to an improved signal separation. Differential cross sections are measured both in photoproduction and in deep inelastic scattering. The measured data are found to be somewhat higher then perturbative QCD calculations to next-to-leading order. A significant excess is observed in certain corners of the kinematic phase space. At the end of this report new and recent beauty measurements are summarised.

  17. Reconciling beauty and utility in early city planning: the contribution of John Nolen.

    PubMed

    Freestone, Robert

    2011-01-01

    In the history of city planning, the dichotomy between the aesthetic aspirations of the City Beautiful and City Practical movements is overstated. The aesthetic impulse did not disappear but persisted as an important thread through the development of comprehensive planning approaches into the 1920s. The nexus between beauty and utility was negotiated and expressed across four main discourses: broad social improvement, aesthetic functionality, economic rationality, and holistic design. Ultimately, beauty became wedded to utility within the very nature of the comprehensive city plan itself. The work of the leading city planner John Nolen is central to an understanding of these historic continuities and informed the early evolution of city planning theory and practice. Nolen’s challenge to the City Beautiful paradigm, while still retaining an artistic sensibility, reaestheticizes scholars’ appreciation of the City Practical. PMID:21299024

  18. Conference summary: 6th International conference on hyperons, charm, and beauty hadrons (BEACH04)

    SciTech Connect

    Butler, Joel N.; /Fermilab

    2004-12-01

    The 6th International Conference on Hyperons, Charm, and Beauty Hadrons (BEACH04) treated us to a wonderful array of new results. Here the author attempts to summarize the talks and discuss the conference highlights.

  19. Did the perils of abdominal obesity affect depiction of feminine beauty in the sixteenth to eighteenth century British literature? Exploring the health and beauty link

    PubMed Central

    Singh, Devendra; Renn, Peter; Singh, Adrian

    2007-01-01

    ‘Good gene’ mate selection theory proposes that all individuals share evolved mental mechanisms that identify specific parts of a woman's body as indicators of fertility and health. Depiction of feminine beauty, across time and culture, should therefore emphasize the physical traits indicative of health and fertility. Abdominal obesity, as measured by waist size, is reliably linked to decreased oestrogen, reduced fecundity and increased risk for major diseases. Systematic searches of British literature across the sixteenth, seventeenth and eighteenth centuries reveal that a narrow waist is consistently described as beautiful. Works in ancient Indian and Chinese literature similarly associate feminine attractiveness with a narrow waist. Even without the benefit of modern medical knowledge, both British and Asian writers knew intuitively the biological link between health and beauty. PMID:17251110

  20. Reflections on beauty as it relates to health in adolescent females.

    PubMed

    Freedman, R J

    1984-01-01

    Because an attractive appearance is so essential to the feminine gender role, the search for beauty causes special adjustment problems for adolescent girls. Psychologically they suffer from negative body image, lowered self-esteem, and achievement conflicts. Physically their health is undermined by current beauty norms which foster eating disorders, cosmetic acne, and breast surgery. The effects of physical fitness programs, the role of the media, and the influence of changing gender roles are also discussed. PMID:6235678

  1. Mixing and CP violation in the beauty and charm sectors at LHCb

    NASA Astrophysics Data System (ADS)

    López March, Neus

    2014-04-01

    The LHCb detector is a dedicated heavy flavour experiment operating at the Large Hadron Collider designed to pursue an extensive study of CP violation in the beauty and charm sectors. In the first part of this contribution, important milestones towards the measurement of CP violation in the beauty sector using B± and Bs0 decays are presented. In the second part, highlights of the searches of CP violation in the charm sector are reported.

  2. "You are so beautiful"*: behind women's attractiveness towards the biology of reproduction: a narrative review.

    PubMed

    Buggio, Laura; Vercellini, Paolo; Somigliana, Edgardo; Viganò, Paola; Frattaruolo, Maria Pina; Fedele, Luigi

    2012-10-01

    Female beauty has always attracted human beings. In particular, beauty has been interpreted in terms of reproductive potential and advantage in selection of mates. We have reviewed the recent literature on female facial and physical beauty with the objective of defining which parameters could influence female attractiveness. Symmetry, averageness, and sexual dimorphism with regards to facial beauty, as well as waist-to-hip ratio (WHR), breast size, and body mass index (BMI) for physical beauty, have been assessed. In current societies, it appears that facial attractiveness results from a mixture of symmetry and averageness of traits, high forehead and cheekbones, small nose and chin, full lips, thin eyebrows, and thick hair. A low WHR reliably characterized physical attractiveness, whereas inconsistencies have been observed in the evaluation of breast size and BMI. The importance of breast size appears to vary with time and sex of evaluators, whereas the impact of BMI is related to socio-economic conditions. The various hypotheses behind beauty and the role of attractiveness in mate choice and sexual selection are here described in terms of continuation of human species. Intriguing associations are emerging between features of attractiveness and some reproductive disorders, as both are substantially influenced by sex steroid hormones. PMID:22394274

  3. The realization of absolute beauty: an interpretation of the fairytale Snow White.

    PubMed

    Takenaka, Nanae

    2016-09-01

    This paper interprets the fairytale Snow White (Bruder Grimm 1857) in terms of the realization of absolute beauty. Jung's understanding that 'in myths and fairytales, as in dreams, the soul speaks about itself' (Jung 1945, para. 400), underpins such an approach. From this perspective a fantasy image is not about us, not about our unconsciousness, but is essentially about itself. The idea of absolute beauty first arises in the Queen's mind as a wish. Despite the Queen's strong desire to be named as the most beautiful person in the world, her mirror reflects that it is actually her daughter Snow White who is the fairest. Snow White might be regarded in the language of Giegerich as her internal other. Effectively they are separated into the Real that conceives the idea of absolute beauty and the Ideal that embodies it. The exchange that takes place between the two - mediated by mirror and window - generates the corpse of surpassing beauty that never decays but lies inaccessible behind the glass coffin. However the loving and penetrating gaze of the Prince, representing masculinity, succeeds in reanimating Snow White. Thus the Prince as the Other that is completely external and unknown to both the Queen and Snow White, specifically to their femininity, facilitates the realization of absolute beauty as the Ideal in the Real. PMID:27530170

  4. Sleeping Beauty Mouse Models Identify Candidate Genes Involved in Gliomagenesis

    PubMed Central

    Vyazunova, Irina; Maklakova, Vilena I.; Berman, Samuel; De, Ishani; Steffen, Megan D.; Hong, Won; Lincoln, Hayley; Morrissy, A. Sorana; Taylor, Michael D.; Akagi, Keiko; Brennan, Cameron W.; Rodriguez, Fausto J.; Collier, Lara S.

    2014-01-01

    Genomic studies of human high-grade gliomas have discovered known and candidate tumor drivers. Studies in both cell culture and mouse models have complemented these approaches and have identified additional genes and processes important for gliomagenesis. Previously, we found that mobilization of Sleeping Beauty transposons in mice ubiquitously throughout the body from the Rosa26 locus led to gliomagenesis with low penetrance. Here we report the characterization of mice in which transposons are mobilized in the Glial Fibrillary Acidic Protein (GFAP) compartment. Glioma formation in these mice did not occur on an otherwise wild-type genetic background, but rare gliomas were observed when mobilization occurred in a p19Arf heterozygous background. Through cloning insertions from additional gliomas generated by transposon mobilization in the Rosa26 compartment, several candidate glioma genes were identified. Comparisons to genetic, epigenetic and mRNA expression data from human gliomas implicates several of these genes as tumor suppressor genes and oncogenes in human glioblastoma. PMID:25423036

  5. NMR structural analysis of Sleeping Beauty transposase binding to DNA

    PubMed Central

    E Carpentier, Claire; Schreifels, Jeffrey M; Aronovich, Elena L; Carlson, Daniel F; Hackett, Perry B; Nesmelova, Irina V

    2014-01-01

    The Sleeping Beauty (SB) transposon is the most widely used DNA transposon in genetic applications and is the only DNA transposon thus far in clinical trials for human gene therapy. In the absence of atomic level structural information, the development of SB transposon relied primarily on the biochemical and genetic homology data. While these studies were successful and have yielded hyperactive transposases, structural information is needed to gain a mechanistic understanding of transposase activity and guides to further improvement. We have initiated a structural study of SB transposase using Nuclear Magnetic Resonance (NMR) and Circular Dichroism (CD) spectroscopy to investigate the properties of the DNA-binding domain of SB transposase in solution. We show that at physiologic salt concentrations, the SB DNA-binding domain remains mostly unstructured but its N-terminal PAI subdomain forms a compact, three-helical structure with a helix-turn-helix motif at higher concentrations of NaCl. Furthermore, we show that the full-length SB DNA-binding domain associates differently with inner and outer binding sites of the transposon DNA. We also show that the PAI subdomain of SB DNA-binding domain has a dominant role in transposase's attachment to the inverted terminal repeats of the transposon DNA. Overall, our data validate several earlier predictions and provide new insights on how SB transposase recognizes transposon DNA. PMID:24243759

  6. Efficient Sleeping Beauty DNA Transposition From DNA Minicircles

    PubMed Central

    Sharma, Nynne; Cai, Yujia; Bak, Rasmus O; Jakobsen, Martin R; Schrøder, Lisbeth Dahl; Mikkelsen, Jacob Giehm

    2013-01-01

    DNA transposon-based vectors have emerged as new potential delivery tools in therapeutic gene transfer. Such vectors are now showing promise in hematopoietic stem cells and primary human T cells, and clinical trials with transposon-engineered cells are on the way. However, the use of plasmid DNA as a carrier of the vector raises safety concerns due to the undesirable administration of bacterial sequences. To optimize vectors based on the Sleeping Beauty (SB) DNA transposon for clinical use, we examine here SB transposition from DNA minicircles (MCs) devoid of the bacterial plasmid backbone. Potent DNA transposition, directed by the hyperactive SB100X transposase, is demonstrated from MC donors, and the stable transfection rate is significantly enhanced by expressing the SB100X transposase from MCs. The stable transfection rate is inversely related to the size of circular donor, suggesting that a MC-based SB transposition system benefits primarily from an increased cellular uptake and/or enhanced expression which can be observed with DNA MCs. DNA transposon and transposase MCs are easily produced, are favorable in size, do not carry irrelevant DNA, and are robust substrates for DNA transposition. In accordance, DNA MCs should become a standard source of DNA transposons not only in therapeutic settings but also in the daily use of the SB system. PMID:23443502

  7. Hadronic decays of beauty and charm from CLEO

    NASA Astrophysics Data System (ADS)

    Rodriguez, Jorge L.

    1999-02-01

    A selection of recent results on hadronic charm and beauty decays from the CLEO experiment are presented. We report preliminary evidence for the existence of final state interactions in B decays and the first observation of the decay B0→D*+D*- with a branching fraction of (7.8-3.8+5.4±1.5)×10-4. We also present preliminary results on the first observation of the broad, JP=1+, charmed meson resonance with a mass of mD1(j=1/2)0=2.461-0.34+0.41±0.010±0.032 GeV and a width of Γ=290-79+101±26±36 MeV and branching fraction measurements of the B-→DJ0π-1 decay. Finally, we report on our search for the radial excitation of a spin 1 charmed meson, the D*'1, and on an improved measurement of the ratio of decay rates Γ(D0→K+π-)/Γ(D0→K-π+).

  8. Optimized Sleeping Beauty transposons rapidly generate stable transgenic cell lines.

    PubMed

    Kowarz, Eric; Löscher, Denise; Marschalek, Rolf

    2015-04-01

    Stable gene expression in mammalian cells is a prerequisite for many in vitro and in vivo experiments. However, either the integration of plasmids into mammalian genomes or the use of retro-/lentiviral systems have intrinsic limitations. The use of transposable elements, e.g. the Sleeping Beauty system (SB), circumvents most of these drawbacks (integration sites, size limitations) and allows the quick generation of stable cell lines. The integration process of SB is catalyzed by a transposase and the handling of this gene transfer system is easy, fast and safe. Here, we report our improvements made to the existing SB vector system and present two new vector types for robust constitutive or inducible expression of any gene of interest. Both types are available in 16 variants with different selection marker (puromycin, hygromycin, blasticidin, neomycin) and fluorescent protein expression (GFP, RFP, BFP) to fit most experimental requirements. With this system it is possible to generate cell lines from stable transfected cells quickly and reliably in a medium-throughput setting (three to five days). Cell lines robustly express any gene-of-interest, either constitutively or tightly regulated by doxycycline. This allows many laboratory experiments to speed up generation of data in a rapid and robust manner. PMID:25650551

  9. Reprint of: The Great Beauty of the osteoclast.

    PubMed

    Cappariello, Alfredo; Maurizi, Antonio; Veeriah, Vimal; Teti, Anna

    2014-11-01

    Much has been written recently on osteoclast biology, but this cell type still astonishes scientists with its multifaceted functions and unique properties. The last three decades have seen a change in thinking about the osteoclast, from a cell with a single function, which just destroys the tissue it belongs to, to an "orchestrator" implicated in the concerted regulation of bone turnover. Osteoclasts have unique morphological features, organelle distribution and plasma membrane domain organization. They require polarization to cause extracellular bone breakdown and release of the digested bone matrix products into the circulation. Osteoclasts contribute to the control of skeletal growth and renewal. Alongside other organs, including kidney, gut, thyroid and parathyroid glands, they also affect calcemia and phosphatemia. Osteoclasts are very sensitive to pro-inflammatory stimuli, and studies in the '00s ascertained their tight link with the immune system, bringing about the question why bone needs a cell regulated by the immune system to remove the extracellular matrix components. Recently, osteoclasts have been demonstrated to contribute to the hematopoietic stem cell niche, controlling local calcium concentration and regulating the turnover of factors essential for hematopoietic stem cell mobilization. Finally, osteoclasts are important regulators of osteoblast activity and angiogenesis, both by releasing factors stored in the bone matrix, and secreting "clastokines" that regulate the activity of neighboring cells. All these facets will be discussed in this review article, with the aim of underscoring The Great Beauty of the osteoclast. PMID:25282390

  10. Hawaiian Starlight: Sharing the Beauty of the Hawaiian Skies

    NASA Astrophysics Data System (ADS)

    Cuillandre, J. C.

    Canada-France-Hawaii Telescope Corp. The summit of Mauna Kea (14,000 feet) offers the best viewing of the Cosmos in the northern hemisphere, and the film "Hawaiian Starlight" delivers a pure esthetic experience from the mountain into the Universe. Seven years in the making, this cinematic symphony reveals the spectacular beauty of the mountain and its connection to the Cosmos through the magical influence of time-lapse cinematography scored exclusively (no narration) with the awe-inspiring, critically acclaimed, Halo music by Martin O'Donnell and Michael Salvatori. Daytime and nighttime landscapes and skyscapes alternate with stunning true color images of the Universe captured by an observatory on Mauna Kea, all free of any computer generated imagery. An extended segment of the film will be presented at the Advanced Maui Optical and Space Surveillance Technologies Conference to celebrate the international year of Astronomy 2009, a global effort initiated by the IAU (International Astronomical Union) and UNESCO (United Nations Educational, Scientific and Cultural Organization) to help the citizens of the world rediscover their place in the Universe through the day- and night-time sky, and thereby engage a personal sense of wonder and discovery. Hawaiian Starlight is true to this commitment. The inspiration and technology of the film will be shortly presented by the film's director.

  11. The biopower of beauty: humanitarian imperialisms and global feminisms in an age of terror.

    PubMed

    Nguyen, Mimi Thi

    2011-01-01

    As part of a feminist commitment to collaboration, this article, which appears as a companion essay to Minh-Ha T. Pham's "The Right to Fashion in the Age of Terror," offers a point of departure for thinking about fashion and beauty as processes that produce subjects recruited to, and aligned with, the national interests of the United States in the war on terror. The Muslim woman in the veil and her imagined opposite, the fashionably modern and implicitly Western woman, become convenient metaphors for articulating geopolitical contests of power as human rights concerns, as rescue missions, as beautifying mandates. This essay examines newer iterations of this opposition, after September 11, 2001, in order to demonstrate the critical resonance of a biopolitics of fashion and beauty. After the events of September 11, 2001, George W. Bush's administration launched a military and public relations campaign to promote U.S. national interests using the language of feminism and human rights. While these discourses in the United States helped to reinvigorate a declining economy, and specifically a flagging fashion industry (as Pham addresses in her companion essay), feminism abroad was deployed to very different ends. This article considers the establishment of the Kabul Beauty School by the nongovernmental organization Beauty without Borders, sponsored in large part by the U.S. fashion and beauty industries. Examining troubling histories of beauty's relation to morality, humanity, and security, as well as to neoliberal discourses of self-governance, the author teases out the biopower and biopolitics of beauty, enacted here through programs of empowerment that are inseparable from the geopolitical aims of the U.S. deployment in Afghanistan. PMID:21114080

  12. Dormitory of Physical and Engineering Sciences: Sleeping Beauties May Be Sleeping Innovations

    PubMed Central

    van Raan, Anthony F. J.

    2015-01-01

    A ‘Sleeping Beauty in Science’ is a publication that goes unnoticed (‘sleeps’) for a long time and then, almost suddenly, attracts a lot of attention (‘is awakened by a prince’). The aim of this paper is to present a general methodology to investigate (1) important properties of Sleeping Beauties such as the time-dependent distribution, author characteristics, journals and fields, and (2) the cognitive environment of Sleeping Beauties. We are particularly interested to find out to what extent Sleeping Beauties are application-oriented and thus are potential Sleeping Innovations. In this study we focus primarily on physics (including materials science and astrophysics) and present first results for chemistry and for engineering & computer science. We find that more than half of the SBs are application-oriented. To study the cognitive environments of Sleeping Beauties we develop a new approach in which the cognitive environment of the SBs is analyzed, based on the mapping of Sleeping Beauties using their citation links and conceptual relations, particularly co-citation mapping. In this way we investigate the research themes in which the SBs are ‘used’ and possible causes of why the premature work in the SBs becomes topical, i.e., the trigger of the awakening of the SBs. This approach is tested with a blue skies SB and an application-oriented SB. We think that the mapping procedures discussed in this paper are not only important for bibliometric analyses. They also provide researchers with useful, interactive tools to discover both relevant older work as well as new developments, for instance in themes related to Sleeping Beauties that are also Sleeping Innovations. PMID:26469987

  13. Research in elementary particle physics. Annual report, January 1--October 31, 1992

    SciTech Connect

    Not Available

    1992-11-01

    Experimental and theoretical work on high energy physics is reviewed. Included are preparations to study high-energy electron-proton interactions at HERA, light-cone QCD, decays of charm and beauty particles, neutrino oscillation, electron-positron interactions at CLEO II, detector development, and astrophysics and cosmology.

  14. Letter of Intent for a Tevatron Collider Beauty Factory

    SciTech Connect

    Volk, J.T.; Yager, P.M.; Edelstein, R.; Christian, D.; Lundberg, B.; Reay, N.W.; Reibel, K.; Sidwell, R.A.; Stanton, N.; Kalbfleisch, G.R.; Skubic, P.; /Oklahoma U.

    1987-01-01

    A hadron collider beauty production experiment which will increase our knowledge of mixing, rare decay modes and even of CP violation could be performed using a new type of detector at the upgraded Fermilab Tevatron. In order to progress from the hundreds of thousands of B{bar B} events which can be tagged per year at a luminosity of several times 10{sup 29}/cm{sup 2}-sec to an ultimate yield of tens of millions at a luminosity of several times 10{sup 31}/cm{sup 2}-sec, they also must embark on a learning curve which will take many years and will require development both of hardware and software before achieving a final system. A new high-luminosity intersection region would have to be included as part of the presently-planned Tevatron Collider upgrade. Designing and constructing an initial system will take four years. Thus, in the light of the positive decision on the SSC, a start must be made soon if Fermilab is ever to play a strong role in this exciting area of physics. Designing even the initial system will require several man-years of effort by a dedicated group of people, together with concurrent work in prototyping and testing. They therefore ask that the Physics Advisory Committee give us their opinion of the priority such a project should be given at Fermilab, within the context that eventually it will require a devoted interaction region which accesses the full achieved luminosity of the machine. Initially, they discuss physics accessible as the B{bar B} yield increases. Subsequently, they outline a detector which can be staged, increasing its power (and cost) as we progress along our learning curve. Finally, costs and time schedules are estimated for the initial version of this detector and possible locations are discussed.

  15. Beauty and charm physics at CDF, First results and perspectives

    SciTech Connect

    S. De Cecco

    2003-02-27

    Among CDF physics opportunities, heavy flavour physics is one of the most prominent and promising for the Tevatron run2. Still in the run1 CDF demonstrated that high precision CP violation measurement in the beauty sector as well as B mixing are feasible at hadronic collider, we think here especially to the first measure of sin2{beta} with B{sup 0} {yields} J/PsiK{sub s}{sup 0} decays and that of {Delta}m{sub Bd}. Tevatron accelerator and CDF detector upgrades are extensively discussed in other papers to which we refer to. Here we just recall the new features relevant to heavy flavour physics: New muon detector coverage up to |{eta}| < 1.5 and lower p{sub T} threshold for single and dimuon triggers. New Time of Flight detector (TOF) placed at R = 1.4m, made of 216 scintillator bars. The TOF resolution is 100 ps allowing a K/{pi} separation at 2 {sigma} for p{sub T} (K) < 1.6GeV. With this upgrade the effective dilution {epsilon}D{sup 2} of flavour tagging algorithms will reach 11.3 % (5.7 % in run1). Completely new Silicon Vertex detector SVXII of 5 double layers, other 2 external silicon layer ISL and additional silicon layer L00 at 1.5 cm from the beam pipe; will enhance vertex resolution and acceptance. Trigger system based on L1 fast tracking XFT in the drift chamber and L2 secondary vertex selection through impact parameter measurement based on silicon hits (SVT) gives online rejection of prompt background and direct access to hadronic HF decays. Recent CDF results based on both the lepton and SVT hadronic trigger samples are presented in the following, together with highlights of heavy flavour physics prospects and plans for run2a.

  16. Can we measure beauty? Computational evaluation of coral reef aesthetics

    PubMed Central

    Guibert, Marine; Foerschner, Anja; Co, Tim; Calhoun, Sandi; George, Emma; Hatay, Mark; Dinsdale, Elizabeth; Sandin, Stuart A.; Smith, Jennifer E.; Vermeij, Mark J.A.; Felts, Ben; Dustan, Phillip; Salamon, Peter; Rohwer, Forest

    2015-01-01

    The natural beauty of coral reefs attracts millions of tourists worldwide resulting in substantial revenues for the adjoining economies. Although their visual appearance is a pivotal factor attracting humans to coral reefs current monitoring protocols exclusively target biogeochemical parameters, neglecting changes in their aesthetic appearance. Here we introduce a standardized computational approach to assess coral reef environments based on 109 visual features designed to evaluate the aesthetic appearance of art. The main feature groups include color intensity and diversity of the image, relative size, color, and distribution of discernable objects within the image, and texture. Specific coral reef aesthetic values combining all 109 features were calibrated against an established biogeochemical assessment (NCEAS) using machine learning algorithms. These values were generated for ∼2,100 random photographic images collected from 9 coral reef locations exposed to varying levels of anthropogenic influence across 2 ocean systems. Aesthetic values proved accurate predictors of the NCEAS scores (root mean square error < 5 for N ≥ 3) and significantly correlated to microbial abundance at each site. This shows that mathematical approaches designed to assess the aesthetic appearance of photographic images can be used as an inexpensive monitoring tool for coral reef ecosystems. It further suggests that human perception of aesthetics is not purely subjective but influenced by inherent reactions towards measurable visual cues. By quantifying aesthetic features of coral reef systems this method provides a cost efficient monitoring tool that targets one of the most important socioeconomic values of coral reefs directly tied to revenue for its local population. PMID:26587350

  17. Better Spectrometers, Beautiful Spectra and Confusion for All

    NASA Technical Reports Server (NTRS)

    Pearson, J. C.; Brauer, C. S.; Drouin, B. J.; Yu, S.

    2009-01-01

    The confluence of enormous improvements in submillimeter receivers and the development of powerful large scale observatories is about to force astrophysics and the sciences that support it to develop novel approaches for interpretation of data. The historical method of observing one or two lines and carefully analyzing them in the context of a simple model is now only applicable for distant objects where only a few lines are strong enough to be observable. Modern observatories collect many GHz of high signal-to-noise spectra in a single observation and in many cases, at sufficiently high spatial resolution to start resolving chemically distinct regions. The observatories planned for the near future and the inevitable upgrades of existing facilities will make large spectral data sets the rule rather than the exception in many areas of molecular astrophysics. The methodology and organization required to fully extract the available information and interpret these beautiful spectra represents a challenge to submillimeter astrophysics similar in magnitude to the last few decades of effort in improving receivers. The quality and abundance of spectra effectively prevents line-by-line analysis from being a time efficient proposition, however, global analysis of complex spectra is a science in its infancy. Spectroscopy at several other wavelengths have developed a number of techniques to analyze complex spectra, which can provide a great deal of guidance to the molecular astrophysics community on how to attack the complex spectrum problem. Ultimately, the challenge is one of organization, similar to building observatories, requiring teams of specialists combining their knowledge of dynamical, structural, chemical and radiative models with detailed knowledge in molecular physics and gas and grain surface chemistry to extract and exploit the enormous information content of complex spectra. This paper presents a spectroscopists view of the necessary elements in a tool for

  18. Can we measure beauty? Computational evaluation of coral reef aesthetics.

    PubMed

    Haas, Andreas F; Guibert, Marine; Foerschner, Anja; Co, Tim; Calhoun, Sandi; George, Emma; Hatay, Mark; Dinsdale, Elizabeth; Sandin, Stuart A; Smith, Jennifer E; Vermeij, Mark J A; Felts, Ben; Dustan, Phillip; Salamon, Peter; Rohwer, Forest

    2015-01-01

    The natural beauty of coral reefs attracts millions of tourists worldwide resulting in substantial revenues for the adjoining economies. Although their visual appearance is a pivotal factor attracting humans to coral reefs current monitoring protocols exclusively target biogeochemical parameters, neglecting changes in their aesthetic appearance. Here we introduce a standardized computational approach to assess coral reef environments based on 109 visual features designed to evaluate the aesthetic appearance of art. The main feature groups include color intensity and diversity of the image, relative size, color, and distribution of discernable objects within the image, and texture. Specific coral reef aesthetic values combining all 109 features were calibrated against an established biogeochemical assessment (NCEAS) using machine learning algorithms. These values were generated for ∼2,100 random photographic images collected from 9 coral reef locations exposed to varying levels of anthropogenic influence across 2 ocean systems. Aesthetic values proved accurate predictors of the NCEAS scores (root mean square error < 5 for N ≥ 3) and significantly correlated to microbial abundance at each site. This shows that mathematical approaches designed to assess the aesthetic appearance of photographic images can be used as an inexpensive monitoring tool for coral reef ecosystems. It further suggests that human perception of aesthetics is not purely subjective but influenced by inherent reactions towards measurable visual cues. By quantifying aesthetic features of coral reef systems this method provides a cost efficient monitoring tool that targets one of the most important socioeconomic values of coral reefs directly tied to revenue for its local population. PMID:26587350

  19. The general theory of relativity - Why 'It is probably the most beautiful of all existing theories'

    NASA Astrophysics Data System (ADS)

    Chandrasekhar, S.

    1984-03-01

    An attempt is made to objectively evaluate the frequent judgment of Einstein's general theory of relativity, by such distinguished physicists as Pauli (1921), Dirac, Born, and Rutherford, as 'beautiful' and 'a work of art'. The criteria applied are that of Francis Bacon ('There is no excellent beauty that hath not some strangeness in the proportions') and that of Heisenberg ('Beauty is the proper conformity of the parts to one another and to the whole'). The strangeness in the proportions of the theory of general relativity consists in its relating, through juxtaposition, the concepts of space and time and those of matter and motion; these had previously been considered entirely independent. The criterion of 'conformity' is illustrated through the directness with which the theory allows the description of black holes.

  20. Cognitive control and unusual decisions about beauty: an fMRI study

    PubMed Central

    Flexas, Albert; Rosselló, Jaume; de Miguel, Pedro; Nadal, Marcos; Munar, Enric

    2014-01-01

    Studies of visual esthetic preference have shown that people without art training generally prefer representational paintings to abstract paintings. This, however, is not always the case: preferences can sometimes go against this usual tendency. We aimed to explore this issue, investigating the relationship between “unusual responses” and reaction time in an esthetic appreciation task. Results of a behavioral experiment confirmed the trend for laypeople to consider as beautiful mostly representational stimuli and as not beautiful mostly abstract ones (“usual response”). Furthermore, when participants gave unusual responses, they needed longer time, especially when considering abstract stimuli as beautiful. We interpreted this longer time as greater involvement of cognitive mastering and evaluation processes during the unusual responses. Results of an fMRI experiment indicated that the anterior cingulate (ACC), orbitofrontal cortex (OFC) and insula were the main structures involved in this effect. We discuss the possible role of these areas in an esthetic appreciation task. PMID:25100970

  1. Darwin's beautiful notion: sexual selection and the plurality of moral codes.

    PubMed

    Tipton, J A

    1999-01-01

    One of the explicit objectives of Darwin's Descent of Man, and Selection in Relation to Sex was to explain cultural differences seen in human beings. Such an explanation, Darwin believed, was to rest upon an understanding of sexual selection. I examine the role that the beautiful plays within the mechanism of sexual selection as it works to differentiate isolated groups. It is suggested that an examination of the relationship between sexual selection and artificial selection--a relationship mediated by the beautiful--will illuminate key issues of the Descent as well as contemporary debates regarding the relationship between evolution and ethics. The beautiful, originally rooted in sexual selection, can become de-coupled from sexual selection and utilized in some selective process which is conscious. PMID:11004944

  2. How beauty works. Theoretical mechanisms and two empirical applications on students' evaluation of teaching.

    PubMed

    Wolbring, Tobias; Riordan, Patrick

    2016-05-01

    Plenty of studies show that the physical appearance of a person affects a variety of outcomes in everyday life. However, due to an incomplete theoretical explication and empirical problems in disentangling different beauty effects, it is unclear which mechanisms are at work. To clarify how beauty works we present explanations from evolutionary theory and expectation states theory and show where both perspectives differ and where interlinkage appears promising. Using students' evaluations of teaching we find observational and experimental evidence for the different causal pathways of physical attractiveness. First, independent raters strongly agree over the physical attractiveness of a person. Second, attractive instructors receive better student ratings. Third, students attend classes of attractive instructors more frequently - even after controlling for teaching quality. Fourth, we find no evidence that attractiveness effects become stronger if rater and ratee are of the opposite sex. Finally, the beauty premium turns into a penalty if an attractive instructor falls short of students' expectations. PMID:26973043

  3. 76 FR 21802 - Notice Announcing the Price of the 2010 America the Beautiful Five Ounce Silver Uncirculated CoinsTM

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-18

    ... Uncirculated CoinsTM ACTION: Notice. SUMMARY: The United States Mint is announcing the price of the 2010 America the Beautiful Five Ounce Silver Uncirculated Coins TM . In accordance with 31 U.S.C. 5112(u) & 9701(b), the United States Mint 2010 America the Beautiful Five Ounce Silver Uncirculated Coins TM...

  4. Talking Back to the Media Ideal: The Development and Validation of the Critical Processing of Beauty Images Scale

    ERIC Educational Resources Information Center

    Engeln-Maddox, Renee; Miller, Steven A.

    2008-01-01

    This article details the development of the Critical Processing of Beauty Images Scale (CPBI) and studies demonstrating the psychometric soundness of this measure. The CPBI measures women's tendency to engage in critical processing of media images featuring idealized female beauty. Three subscales were identified using exploratory factor analysis…

  5. 78 FR 5245 - Pricing for New Product-America the Beautiful Quarters® Three-Roll Set

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY United States Mint Pricing for New Product--America the Beautiful Quarters Three-Roll Set AGENCY: United... pricing for a new product, the America the Beautiful Quarters Three-Roll Set. This product will be...

  6. A Search for Charm and Beauty in a Very Strange World

    NASA Astrophysics Data System (ADS)

    Kamin, Jason Adrian

    The Relativistic Heavy Ion Collider (RHIC) was built to produce and study the extremely hot and dense phase of matter called Quark Gluon Plasma (QGP) in which the degrees of freedom are individual partons rather than composite hadrons. Since 2000, RHIC has collided various species of particles in order to disentangle and isolate the properties of the strongly interacting QGP: p+p to set a baseline, d+Au to establish a control experiment, Au+Au to definitively create the QGP, and Cu+Cu to bridge the gap between d+Au and Au+Au. Electron-positron pairs are a particularly effective probe of the QGP because they carry no color charge. Therefore, once created, these leptons do not interact strongly with the medium. As a result, they retain characteristics of the full time evolution and dynamics of the system. There are many features of interest in the dielectron invariant mass spectrum. The low mass region (< 1 GeV/c2) consists primarily of pairs from Dalitz decays of light hadrons and direct decays of vector mesons that can be modified by the medium, while the intermediate (1 < m < 3 GeV/c2) and high (4 < m < 8 GeV/c2) mass regions are dominated by pairs from mesons containing charm and beauty respectively. Of the multitude of measurements that PHENIX has produced over the last decade, one of the more mysterious and intriguing is a large enhancement of pairs in the low mass region in central Au+Au collisions compared to the p+p reference. Current theories are unable to explain the origin of this excess and a lingering question within the field is whether the presence of "cold" nuclear matter in the initial state of the collision, independent of the formation of a QGP, could possibly account for this increased yield. To answer this question, this thesis explores the dielectron spectra in

  7. Combining universal beauty and cultural context in a unifying model of visual aesthetic experience

    PubMed Central

    Redies, Christoph

    2015-01-01

    In this work, I propose a model of visual aesthetic experience that combines formalist and contextual aspects of aesthetics. The model distinguishes between two modes of processing. First, perceptual processing is based on the intrinsic form of an artwork, which may or may not be beautiful. If it is beautiful, a beauty-responsive mechanism is activated in the brain. This bottom–up mechanism is universal amongst humans; it is widespread in the visual brain and responsive across visual modalities. Second, cognitive processing is based on contextual information, such as the depicted content, the intentions of the artist or the circumstances of the presentation of the artwork. Cognitive processing is partially top–down and varies between individuals according to their cultural experience. Processing in the two channels is parallel and largely independent. In the general case, an aesthetic experience is induced if processing in both channels is favorable, i.e., if there is resonance in the perceptual processing channel (“aesthetics of perception”), and successful mastering in the cognitive processing channel (“aesthetics of cognition”). I speculate that this combinatorial mechanism has evolved to mediate social bonding between members of a (cultural) group of people. Primary emotions can be elicited via both channels and modulate the degree of the aesthetic experience. Two special cases are discussed. First, in a subset of (post-)modern art, beauty no longer plays a prominent role. Second, in some forms of abstract art, beautiful form can be enjoyed with minimal cognitive processing. The model is applied to examples of Western art. Finally, implications of the model are discussed. In summary, the proposed model resolves the seeming contradiction between formalist perceptual approaches to aesthetic experience, which are based on the intrinsic beauty of artworks, and contextual approaches, which account for highly individual and culturally dependent aspects of

  8. Role of beauty treatment in the spread of parenterally transmitted hepatitis viruses in Italy.

    PubMed

    Mariano, Andrea; Mele, Alfonso; Tosti, Maria Elena; Parlato, Antonino; Gallo, Giovanni; Ragni, Pietro; Zotti, Carla; Lopalco, Pierluigi; Pompa, Maria Grazia; Graziani, Grazia; Stroffolini, Tommaso

    2004-10-01

    The aims of the study were to evaluate the role of beauty treatments in the spread of acute viral hepatitis B (HBV) and acute viral hepatitis C (HCV) in Italy. Data from the surveillance system for acute viral hepatitis (SEIEVA) during the period 1997-2002 were used. After exclusion of subjects <15 years or >55 years old and reporting intravenous drug use or blood transfusion, the association of acute HBV and HCV cases with beauty treatments (tattooing, piercing, manicure/chiropody, and barber shop shaving) was estimated comparing 2,964 hepatitis B and 598 hepatitis C cases with 7,221 hepatitis A cases, used as controls, by multiple logistic regression analysis. The population attributable risk (PAR) to beauty treatments was estimated according to Levin's formula. Beauty treatments were associated with acute HBV (OR = 1.8; CI 95% = 1.5-2.1) and acute HCV (OR = 1.7; CI 95% = 1.2-2.3). The strongest association was found with barber shop shaving for HBV (OR = 1.8; CI 95% = 1.5-2.2) and with tattooing for HCV cases (OR = 5.6; CI 95% = 2.8-11.0). The estimates of the population attributable risk (PAR) indicate that nearly 15% of all acute HBV (17.4% in males) and 11.5% of all acute HCV cases (16.4% in males) occurring in 15-55 year old subjects not exposed to intravenous drugs or blood transfusion in Italy are due to beauty treatments. It is concluded that certain beauty treatments play an important role in the spread of HBV and HCV infections in Italy. PMID:15332269

  9. Nennu and Shunu: gender, body politics, and the beauty economy in China.

    PubMed

    Yang, Jie

    2011-01-01

    This essay analyzes recent discourse on two emerging representations of women in China, "tender" women (nennu) and "ripe" women (shunu), in order to examine the relationships among gender, body politics, and consumerism. The discourse of nennu and shunu suggests that older, ripe women become younger and more tender by consuming fashions, cosmetic surgery technologies, and beauty and health care products and services because tender women represent the ideal active consumership that celebrates beauty, sexuality, and individuality. This discourse serves to enhance consumers' desire for beauty and health and to ensure the continued growth of China's beauty economy and consumer capitalism. Highlighting the role of the female body, feminine beauty, and feminine youth in developing consumerism, this discourse downplays the contributions of millions of beauty and health care providers (predominantly laid-off female workers and rural migrant women) and new forms of gender exploitation. Such an overemphasis on gender masks intensified class division. This essay suggests that women and their bodies become new terrains from which post-Mao China can draw its power and enact consumerism. Gender constitutes both an economic multiplier to boost China's consumer capitalism and a biopolitical strategy to regulate and remold women and their bodies into subjects that are identified with the state's political and economic objectives. Since consumerism has been incorporated into China's nation-building project, gender thus becomes a vital resource for both consumer capitalist development and nation building. This essay shows that both gender and the body are useful analytic categories for the study of postsocialism. PMID:21114079

  10. Combining universal beauty and cultural context in a unifying model of visual aesthetic experience.

    PubMed

    Redies, Christoph

    2015-01-01

    In this work, I propose a model of visual aesthetic experience that combines formalist and contextual aspects of aesthetics. The model distinguishes between two modes of processing. First, perceptual processing is based on the intrinsic form of an artwork, which may or may not be beautiful. If it is beautiful, a beauty-responsive mechanism is activated in the brain. This bottom-up mechanism is universal amongst humans; it is widespread in the visual brain and responsive across visual modalities. Second, cognitive processing is based on contextual information, such as the depicted content, the intentions of the artist or the circumstances of the presentation of the artwork. Cognitive processing is partially top-down and varies between individuals according to their cultural experience. Processing in the two channels is parallel and largely independent. In the general case, an aesthetic experience is induced if processing in both channels is favorable, i.e., if there is resonance in the perceptual processing channel ("aesthetics of perception"), and successful mastering in the cognitive processing channel ("aesthetics of cognition"). I speculate that this combinatorial mechanism has evolved to mediate social bonding between members of a (cultural) group of people. Primary emotions can be elicited via both channels and modulate the degree of the aesthetic experience. Two special cases are discussed. First, in a subset of (post-)modern art, beauty no longer plays a prominent role. Second, in some forms of abstract art, beautiful form can be enjoyed with minimal cognitive processing. The model is applied to examples of Western art. Finally, implications of the model are discussed. In summary, the proposed model resolves the seeming contradiction between formalist perceptual approaches to aesthetic experience, which are based on the intrinsic beauty of artworks, and contextual approaches, which account for highly individual and culturally dependent aspects of aesthetics

  11. PA01.75. Hidden beauty concepts in ayurveda w.r.t agada tantra

    PubMed Central

    Kalyanimath, Gurusiddeshwar J.; Sharanesh, T.; Ashwinikumar; Anita, M.

    2012-01-01

    Purpose: Beauty is not in the face; Beauty is a light in the heart. In our Ayurveda it is stated that Physical, Mental and Spiritual beauty as a combined unit projects the cosmetic sense of Ayurveda (Ch.Su 1/41). According to Ayurveda healthy skin is the result of overall condition of individuals and prescribes numerous skin care treatments that need to be pursued at every stage of life. Ayurveda determines beauty by Prakruti(body constitution), Sara (structural predominance), Samhanana (compactness of body), Twak (skin complexion), Pramana (measurement) and Dirghayu lakshana (symptom of long life). Ayurveda cosmetology started with garbhini paricharya, Dinacharya, Ratricharya and Ritucharya with practice of medicinal herbs and minerals. In day-to-day life, knowingly or unknowingly we exposing lots of chemicals /toxins to our body, those spoiling our natural beauty silently, this same concept is explained in Agada tantra under concept of Dhooshivisha (Su.Ka 2/33) and Garaviasha. Method: 1. Literature review of concept related to cosmetology in relation to Agada Tantra.2. Analysis and Interpretation of mode of action of Agada yoga's in relieving the symptoms of Twak vikaras. Result: 1. Specific Agada yogas like Bilwadi Agada , Dhooshivishari Agada, Moorvadi choorna, Paarantyadi Keram shows best preventive and curative action in twak vikaras.2. Some of the Agadas like Moorvadi choona (A.hrudaya) lepas have enhansess the internal and external beauty. Conclusion: Agada tantra is not only a branch of Ayurveda it deals with management of acute and chronic diseases but also a added benefit of being used for cosmetology.

  12. Mercury poisoning associated with beauty cream--Texas, New Mexico, and California, 1995-1996.

    PubMed

    1996-05-17

    The Texas Department of Health (TDH), New Mexico Department of Health (NMDH), and San Diego County Health Department (SDCHD) recently investigated three cases of mercury poisoning among persons who had used a beauty cream produced in Mexico. The investigations implicated the beauty cream as the source of the mercury. The cream, marketed as "Crema de Belleza--Manning," lists "calomel" (mercurous chloride) as an ingredient and was found to contain 6%-8% mercury by weight. This report summarizes the ongoing investigation of these and other possible cases. PMID:8609883

  13. Measurement of Beauty and Charm Photoproduction at H1 using inclusive lifetime tagging

    SciTech Connect

    Finke, L.

    2005-10-06

    A measurement of the charm and beauty photoproduction cross sections at the ep collider HERA is presented. The lifetime signature of c and b-flavoured hadrons is exploited to determine the fractions of events in the sample containing charm or beauty. Differential cross sections as a function of the jet transverse momentum, the rapidity and x{sub {gamma}}{sup obs} are measured in the photoproduction region Q2 < 1 GeV2, with inelasticity 0.15 < y < 0.8. The results are compared with calculations in next-to-leading order perturbative QCD and Monte Carlo models as implemented in PYTHIA and CASCADE.

  14. The History and Aim of LADY CATS —Simple and Beautiful Experiments

    NASA Astrophysics Data System (ADS)

    Tanemura, Masako; Okiharu, Fumiko; Yokoe, Mika; Taniguchi, Masa-aki; Maeda, Hiroaki; Kutome, Yuusuke; Kawakatsu, Hiroshi

    LADY CATS (LADY Creators of Activities for Teaching Science) is an organization of science teachers. Our group includes a lot of female teachers. We have demonstrated "Simple and beautiful experiments" since ICPE 2005. We aim to encourage both students and teachers who are not interested in physics. Our concepts of experiments are as follows: the "simple" experiments which the teachers in the world can utilize in their classes easily, the "beautiful" experiments in which children get interested, and the "essential" experiments which can demonstrate the principles of physics. We demonstrate several educational experiments of our group.

  15. Underlying Asymmetry with Particle-Size Segregation

    NASA Astrophysics Data System (ADS)

    Gajjar, Parmesh; van der Vaart, Kasper; Epely-Chauvin, Gael; Andreini, Nicolas; Gray, Nico; Ancey, Christophe

    2015-11-01

    Granular media have a natural tendency to self-organise when sheared, with different sized constituents counter-intuitively separating from each other. Not only does the segregation produce a rich diversity of beautiful patterns, but it can also have serious implications in both industrial and geophysical environments. Despite the universal importance, the individual particle dynamics during segregation are still poorly understand, with such an analysis proving to be difficult with conventional techniques such as binning and sidewall observation. This talk will present results of recent experiments that studied particle scale segregation dynamics during oscillatory shear. Refractive index matched scanning allowed examination of the interior of the flow, where it was observed that large and small particles have an underlying asymmetry that is dependant on the local particle concentration. Small particles were seen to segregate faster through regions of many large particles, whilst large particles rise slower through regions of many small particles. The asymmetry is quantified on both bulk and particle length scales, and is shown to have good agreement with a continuum model that uses a cubic segregation flux.

  16. Geological beauties and Landscape: new proposals to communicate the Geodiversity

    NASA Astrophysics Data System (ADS)

    Lugeri, Francesca; Farabollini, Piero; Amadio, Vittorio

    2015-04-01

    The European Landscape Convention proposes a concept of the landscape itself as an expression of the diversity of the natural, cultural and economic development of the population and identifies society as responsible of such a heritage. The landscape has a concrete value as natural resource and basis of functional processes that support life; it also has an important symbolic value: the consequences of the loss of landscape have been and still are devastating, even on a social level. The Landscape is object of human perceptions and, at the same time, can be considered the result of the interaction of many natural and cultural components: therefore it could become a "medium" to communicate the Earth Sciences to the whole society: the geo-morphological sciences are a powerful tool in order to explain and share a "sense of natural identity". The consciousness of being part of an ecosystem, is achieved through the knowledge and the experience of the environment. In order to create effective and efficient sensitivity in individuals and in communities, it is essential to explain the importance of geodiversity, which - integrated to bio diversity- contributes to the concept of "environmental diversity" essential balance of the planet and resource for the economy. The difficulty for the scientific communicators in reaching the wider public, requires new integrated solutions. A very positive experience is related to the project "GeoloGiro" geology at the Giro d'Italia, (realized thanks to a cooperation between ISPRA Geological Survey and the Italian Council of Geologists) which provides a TV time dedicated to make comprehensible the reasons of the geological and environmental beauties of the territory crossed by cyclists during each stage. A further project development, includes the transmission of a short cartoon in which a strange character - a pink dinosaur named GiROSAuro, cycling fan, pink as the jersey worn by the winners of the "Giro d 'Italia"- explains to the

  17. 76 FR 65563 - Pricing for America the Beautiful Five Ounce Silver Uncirculated CoinsTM

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY United States Mint Pricing for America the Beautiful Five Ounce Silver Uncirculated Coins TM AGENCY: United States Mint, Department of the Treasury. ACTION: Notice. SUMMARY: The United States Mint...

  18. 77 FR 840 - Pricing for America the Beautiful Five Ounce Silver Uncirculated CoinsTM

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-06

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY United States Mint Pricing for America the Beautiful Five Ounce Silver Uncirculated Coins TM AGENCY: United States Mint, Department of the Treasury. ACTION: Notice. SUMMARY: The United States Mint...

  19. Indoor Air in Beauty Salons and Occupational Health Exposure of Cosmetologists to Chemical Substances

    PubMed Central

    Tsigonia, Alexandra; Lagoudi, Argyro; Chandrinou, Stavroula; Linos, Athena; Evlogias, Nikos; Alexopoulos, Evangelos C.

    2010-01-01

    The indoor environment in four beauty salons located in Athens (Greece) was examined in order to investigate the occupational health exposure of cosmetologists to various chemical products typically used in their work. Chemical substances chosen for investigation were volatile organic compounds (VOCs), formaldehyde, ozone and carbon dioxide. Total VOCs levels measured showed significant variation (100–1,450 μg m−3) depending on the products used and the number of treatments carried out, as well as ventilation. The main VOCs found in the salons were aromatics (toluene, xylene), esters and ketones (ethyl acetate, acetone, etc.) which are used as solvents in various beauty products; terpenes (pinene, limonene, camphor, menthenol) which have a particular odor and others like camphor which have specific properties. Ozone concentrations measured in all salons were quite low (0.1 and 13.3 μg m−3) and formaldehyde concentrations detected were lower than the detection limit of the method in all salons (<0.05 ppm). Carbon dioxide levels ranged between 402 and 1,268 ppm, depending on the number of people present in the salons during measurements and ventilation. Cosmetologists may be exposed to high concentrations of a mixture of volatile organic compounds although these levels could be decreased significantly by following certain practices such as good ventilation of the areas, closing the packages of the beauty products when not in use and finally selecting safer beauty products without strong odor. PMID:20195448

  20. From the Matterhorn to Molecules: The Beauty of the Interstellar Medium

    NASA Astrophysics Data System (ADS)

    Bally, J.

    2016-05-01

    Our generation is opening humanity's eyes to the electromagnetic spectrum, revealing the interstellar medium's stunning beauty and profound role in star and planet formation and cosmic evolution. The enabling technologies of this revolution also have huge impacts on the world's economy.

  1. The "Beauty Is Good" for Children with Autism Spectrum Disorders Too

    ERIC Educational Resources Information Center

    Fonseca, D. Da; Santos, A.; Rosset, D.; Deruelle, C.

    2011-01-01

    The "beauty is good" (BIG) stereotype is a robust and extensively documented social stereotype. While one may think that children with autism are impervious to the BIG stereotype, given their remarkable difficulties in the social sphere, this issue has not yet been addressed. We have asked 18 children with autism to judge how friendly and…

  2. Beautiful math, part 3: hyperbolic aesthetic patterns based on conformal mappings.

    PubMed

    Ouyang, Peichang; Chung, Kwokwai

    2014-01-01

    This third installment of the Beautiful Math articles considers the visualization of aesthetic patterns with hyperbolic-triangle-group symmetries. A flexible form of invariant mappings contributes to a simple, efficient way to generate hyperbolic patterns. Combined with conformal mappings, this method can yield an abundance of exotic patterns. PMID:24808201

  3. A neurobiological enquiry into the origins of our experience of the sublime and beautiful.

    PubMed

    Ishizu, Tomohiro; Zeki, Semir

    2014-01-01

    Philosophies of aesthetics have posited that experience of the sublime-commonly but not exclusively derived from scenes of natural grandeur-is distinct from that of beauty and is a counterpoint to it. We wanted to chart the pattern of brain activity which correlates with the declared intensity of experience of the sublime, and to learn whether it differs from the pattern that correlates with the experience of beauty, reported in our previous studies (e.g., Ishizu and Zeki, 2011). 21 subjects participated in a functional magnetic resonance imaging experiment. Prior to the experiment, they viewed pictures of landscapes, which they rated on a scale of 1-5, with 5 being the most sublime and 1 being the least. This allowed us to select, for each subject, five sets of stimuli-from ones experienced as very sublime to those experienced as not at all sublime-which subjects viewed and re-rated in the scanner while their brain activity was imaged. The results revealed a distinctly different pattern of brain activity from that obtained with the experience of beauty, with none of the areas active with the latter experience also active during experience of the sublime. Sublime and beautiful experiences thus appear to engage separate and distinct brain systems. PMID:25426046

  4. Buying a Beauty Standard or Dreaming of a New Life? Expectations Associated with Media Ideals

    ERIC Educational Resources Information Center

    Engeln-Maddox, Renee

    2006-01-01

    This study explored college women's ideas regarding how their lives would change if their appearance were consistent with a media-supported female beauty ideal. Participants rated self-generated life changes they associated with looking like a media ideal in terms of likelihood and positivity. Women's tendency to link positive and likely life…

  5. Reading and Writing the World Using Beautiful Books: Language Experience Re-Envisioned

    ERIC Educational Resources Information Center

    Hoffman, James V.; Roser, Nancy

    2012-01-01

    Through this article, we describe an instructional strategy termed "Beautiful Books." This strategy involves the creation of images and texts to be used in the development of oral and literacy skills. We explore the historical roots of the strategy in Language Experience Approach (LEA) and Whole language and consider how dictation and early…

  6. A Case Study in Jewish Moral Education: (Non-)Rape of the Beautiful Captive

    ERIC Educational Resources Information Center

    Resnick, David

    2004-01-01

    The challenge of teaching classic religious texts with flawed moral messages from a contemporary point of view is examined in the case of the Beautiful Captive of War (Deuteronomy 21:10-14). A moral dilemma is generated by contradictory ethical stands within the Jewish tradition, between which students have to choose. This dilemma is explored in…

  7. Learn in Beauty: A Professional Development Project for Navajo Bilingual Teachers.

    ERIC Educational Resources Information Center

    Lockard, Louise; de Groat, Jennie; Bedonie, Clara

    The Learn in Beauty Project at Northern Arizona University worked with a consortium of seven Navajo Nation school districts seeking to implement the Dine Language and Culture teaching perspective. This perspective is based on the premises that education is best when it reflects a sense of place; education should be based on the philosophy and…

  8. 75 FR 10561 - Pricing for 2010 United States Mint America the Beautiful QuartersTM

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-08

    ... States Mint America the Beautiful Quarters Two-Roll Sets, featuring Hot Springs National Park... Mint facilities at Philadelphia and Denver. The first set, featuring Hot Springs National Park, will be... featuring Hot Springs National Park, Yellowstone National Park, Yosemite National Park, Grand...

  9. Cosmetic Medicine: Innovative Beauty Care as Popular Medicine in Days Gone By.

    PubMed

    Locher, Wolfgang G

    2016-06-01

    Throughout the ages, people yearned for beauty and longevity. This article examines how European physicians began to engage with the field of cosmetics over a century ago, thus introducing the category of aesthetics into medical practice. This historical phenomenon is currently repeating itself. PMID:27248021

  10. New hidden beauty molecules predicted by the local hidden gauge approach and heavy quark spin symmetry

    NASA Astrophysics Data System (ADS)

    Xiao, C. W.; Ozpineci, A.; Oset, E.

    2015-10-01

    Using a coupled channel unitary approach, combining the heavy quark spin symmetry and the dynamics of the local hidden gauge, we investigate the meson-meson interaction with hidden beauty. We obtain several new states of isospin I = 0: six bound states, and weakly bound six more possible states which depend on the influence of the coupled channel effects.

  11. A neurobiological enquiry into the origins of our experience of the sublime and beautiful

    PubMed Central

    Ishizu, Tomohiro; Zeki, Semir

    2014-01-01

    Philosophies of aesthetics have posited that experience of the sublime—commonly but not exclusively derived from scenes of natural grandeur—is distinct from that of beauty and is a counterpoint to it. We wanted to chart the pattern of brain activity which correlates with the declared intensity of experience of the sublime, and to learn whether it differs from the pattern that correlates with the experience of beauty, reported in our previous studies (e.g., Ishizu and Zeki, 2011). 21 subjects participated in a functional magnetic resonance imaging experiment. Prior to the experiment, they viewed pictures of landscapes, which they rated on a scale of 1–5, with 5 being the most sublime and 1 being the least. This allowed us to select, for each subject, five sets of stimuli—from ones experienced as very sublime to those experienced as not at all sublime—which subjects viewed and re-rated in the scanner while their brain activity was imaged. The results revealed a distinctly different pattern of brain activity from that obtained with the experience of beauty, with none of the areas active with the latter experience also active during experience of the sublime. Sublime and beautiful experiences thus appear to engage separate and distinct brain systems. PMID:25426046

  12. Insertional Mutagenesis by a Hybrid PiggyBac and Sleeping Beauty Transposon in the Rat

    PubMed Central

    Furushima, Kenryo; Jang, Chuan-Wei; Chen, Diane W.; Xiao, Ningna; Overbeek, Paul A.; Behringer, Richard R.

    2012-01-01

    A hybrid piggyBac/Sleeping Beauty transposon-based insertional mutagenesis system that can be mobilized by simple breeding was established in the rat. These transposons were engineered to include gene trap sequences and a tyrosinase (Tyr) pigmentation reporter to rescue the albinism of the genetic background used in the mutagenesis strategy. Single-copy transposon insertions were transposed into the rat genome by co-injection of plasmids carrying the transposon and RNA encoding piggyBac transposase into zygotes. The levels of transgenic Tyr expression were influenced by chromosomal context, leading to transgenic rats with different pigmentation that enabled visual genotyping. Transgenic rats designed to ubiquitously express either piggyBac or Sleeping Beauty transposase were generated by standard zygote injection also on an albino background. Bigenic rats carrying single-copy transposons at known loci and transposase transgenes exhibited coat color mosaicism, indicating somatic transposition. PiggyBac or Sleeping Beauty transposase bigenic rats bred with wild-type albino rats yielded offspring with pigmentation distinct from the initial transposon insertions as a consequence of germline transposition to new loci. The germline transposition frequency for Sleeping Beauty and piggyBac was ∼10% or about one new insertion per litter. Approximately 50% of the insertions occurred in introns. Chimeric transcripts containing endogenous and gene trap sequences were identified in Gabrb1 mutant rats. This mutagenesis system based on simple crosses and visual genotyping can be used to generate a collection of single-gene mutations in the rat. PMID:23023007

  13. American Beauty: The Seduction of the Visual Image in the Culture of Technology

    ERIC Educational Resources Information Center

    Goudreau, Kim

    2006-01-01

    The critical examination of the film "American Beauty" reveals characteristics illustrative of the form of culture coextensive with modern technological societies. This form of culture creates an imbalance favoring the aesthetical over the ethical dimensions of human orientation. Absorption into the aesthetical dimension of the electronic or…

  14. The Age of Beauty Calendar for Flood Relief: Photography, Solidarity, Fundraising, and Vibrant Older Women

    ERIC Educational Resources Information Center

    Roy, Carole

    2005-01-01

    "The Age of Beauty: Women for Flood Relief 2005-2006: Celebrating the Spirit of Peterborough," is a calendar that successfully raised funds for flood victims while contributing to the reinvention of images of "powerful rebellious old women" by offering dynamic images of older women's strengths, creativity and spirit. During a time of crisis in…

  15. Health and Beauty Magazine Reading and Body Shape Concerns among a Group of College Women.

    ERIC Educational Resources Information Center

    Thomsen, Steven R.

    2002-01-01

    Examines three potential factors that might mediate the relationship between reading women's magazines and body shape and size concern. Finds that health and fitness magazine reading by college-aged women was linked directly to body shape concerns, indirectly through beliefs about men's thinness expectations. Explains that beauty and fashion…

  16. Discrete cortical regions associated with the musical beauty of major and minor chords.

    PubMed

    Suzuki, Miho; Okamura, Nobuyuki; Kawachi, Yousuke; Tashiro, Manabu; Arao, Hiroshi; Hoshishiba, Takayuki; Gyoba, Jiro; Yanai, Kazuhiko

    2008-06-01

    Previous research has demonstrated that the degree of aesthetic pleasure a person experiences correlates with the activation of reward functions in the brain. However, it is unclear whether different affective qualities and the perceptions of beauty that they evoke correspond to specific areas of brain activation. Major and minor musical keys induce two types of affective qualities--bright/happy and dark/sad--that both evoke aesthetic pleasure. In the present study, we used positron emission tomography to demonstrate that the two musical keys (major and minor) activate distinct brain areas. Minor consonant chords perceived as beautiful strongly activated the right striatum, which has been assumed to play an important role in reward and emotion processing, whereas major consonant chords perceived as beautiful induced significant activity in the left middle temporal gyrus, which is believed to be related to coherent and orderly information processing. These results suggest that major and minor keys, both of which are perceived as beautiful, are processed differently in the brain. PMID:18589503

  17. On the Beauty of Mathematics as Exemplified by a Problem in Combinatorics.

    ERIC Educational Resources Information Center

    Dence, Thomas P.

    1982-01-01

    The beauty of discovering some simple yet elegant proof either to something new or to an already established fact is discussed. A combinatorial problem that deals with covering a checkerboard with dominoes is presented as a starting point for individual investigation of similar problems. (MP)

  18. PREFACE: XI Conference on Beauty, Charm, Hyperons in Hadronic Interactions BEACH

    NASA Astrophysics Data System (ADS)

    Bozzo, Marco

    2014-11-01

    This volume contains the invited and contributed papers presented at the 11th International Conference on Hyperons, Charm and Beauty Hadrons, currently known as the BEACH Conferences. The BEACH conferences cover a broad range of physics topics in the field of Hyperon and heavy-flavor physics. This conference continues the BEACH series, which began with a meeting in Strasbourg in 1995 and since then offers a biennial opportunity for both theorists and experimentalists from the high-energy physics community to discuss all aspects of flavour physics. The 11th Conference took place in the Lecture Theatre of the Physics West Building of the University of Birmingham (United Kingdom) from July 22nd to July 26th and was attended by 107 participants. All of the sessions were plenary sessions accommodating review talks and shorter contributions discussing both theory and recent experiments. At the end of the conference Valerie Gibson (Cavendish Laboratory, University of Cambridge, UK) and Sebastian Jaeger (School of Physics and Astronomy, University of Sussex, UK) summarized and put in context all the presentations of the conference giving two very interesting Summary talks. These Conference Proceedings are particularly interesting since, due to the long shutdown of the LHC in Geneva (CH), most of the data presented were from the entire data set available. This volume in fact offers an interesting panorama of the present situation and allows a comparison of the experimental data and the theory in a field that is always in continuous evolution. The conference was impeccably organized by the Local Organizing Committee chaired by Cristina Lazzeroni (Birmingham Univeristy, Birmingham, UK) that I want to thank particularly here. Many from the University Staff have contributed to the smooth running of the conference. We would like to thank the Local Scientific Secretariat for their invaluable help in making the conference a truly enjoyable and unforgettable event; a special thanks

  19. Beauty and physics: 13 important contributions of Chen Ning Yang

    NASA Astrophysics Data System (ADS)

    Shi, Yu

    2014-06-01

    In 2012, Chen Ning Yang received a 90th birthday gift in the form of a black cube inscribed with his 13 most important contributions, which cover four major areas of physics: statistical mechanics, condensed matter physics, particle physics and field theory. We briefly describe these 13 contributions and make general comments about Yang's distinctive style as a trailblazing leader in research.

  20. Light, Wind and Fire - Beautiful Image of a Cosmic Sculpture

    NASA Astrophysics Data System (ADS)

    2010-02-01

    Today ESO has released a dramatic new image of NGC 346, the brightest star-forming region in our neighbouring galaxy, the Small Magellanic Cloud, 210 000 light-years away towards the constellation of Tucana (the Toucan). The light, wind and heat given off by massive stars have dispersed the glowing gas within and around this star cluster, forming a surrounding wispy nebular structure that looks like a cobweb. NGC 346, like other beautiful astronomical scenes, is a work in progress, and changes as the aeons pass. As yet more stars form from loose matter in the area, they will ignite, scattering leftover dust and gas, carving out great ripples and altering the face of this lustrous object. NGC 346 spans approximately 200 light-years, a region of space about fifty times the distance between the Sun and its nearest stellar neighbours. Astronomers classify NGC 346 as an open cluster of stars, indicating that this stellar brood all originated from the same collapsed cloud of matter. The associated nebula containing this clutch of bright stars is known as an emission nebula, meaning that gas within it has been heated up by stars until the gas emits its own light, just like the neon gas used in electric store signs. Many stars in NGC 346 are relatively young in cosmic terms with their births dating back only a few million years or so (eso0834). Powerful winds thrown off by a massive star set off this recent round of star birth by compressing large amounts of matter, the first critical step towards igniting new stars. This cloud of material then collapses under its own gravity, until some regions become dense and hot enough to roar forth as a brilliantly shining, nuclear fusion-powered furnace - a star, illuminating the residual debris of gas and dust. In sufficiently congested regions like NGC 346, with high levels of recent star birth, the result is a glorious, glowing vista for our telescopes to capture. NGC 346 is in the Small Magellanic Cloud, a dwarf galaxy some 210

  1. Report of the intermediate-)ital p)/sub perpendicular/ detector group: A beauty spectrometer for the SSC (superconducting super collider)

    SciTech Connect

    Foley, K.J.; Buchanan, C.D.; Morrison, R.J.; McHugh, S.W.; Witherell, M.S.; Atac, M.; Cox, B.; Purohit, M.V.; Stefanski, R.; Wagoner, D.E.

    1987-07-01

    A ''Beauty Spectrometer'' has been designed for studies of B physics at the SSC. The ultimate goal is a definitive measurement of CP violation in the B system. The spectrometer consists of two stages and occupies one side of an intermediate-luminosity interaction region. An upstream, or intermediate, stage extends from the interaction point to 14 m and covers the angular region from 57 mrad (3.3 degree) to 350 mrad (20 degree). The forward stage extends to 77 m and to angles down to 5.7 mrad. The design includes silicon microstrip detectors, conventional tracking, momentum analysis, and hadron and lepton identification. While no fundamental problems have been found, the detector must deal with unprecedented particles fluxes, trigger rates, and data rates. 11 refs., 10 figs., 5 tabs.

  2. The optical trigger for beauty research, recent developments and perspectives

    SciTech Connect

    Giomataris, Y.; Perroud, J.; Tran, M.T. ); Chipaux, R.; Derre, J.; Kochowski, C.; Loucatos, S.; Rebourgeard, P. )

    1992-02-05

    An optical detector sensitive to impact parameter has been tested in a particle beam. The device is based on the detection of [hacek C]erenkov light produced and trapped in a thin spherical crystal shell viewed by a fast photodetector. The detector is only sensitive to charged particles with a non-zero impact parameter relative to the center of the crystal sphere. A prototype using a LiF 3 mm thick crystal has been tested and the experimental results are in agreement with the expectations. We discuss applications of this detector for fast selection of B-events in fixed target experiments at proton accelerators. A program of technical development has started, aiming at a high efficiency in B-meson pairs and a rejection factor of 100 against unwanted minimum bias events. We also present a modified collider configuration, the Asymmetric Tilted Collider, to optimize the sensitivity and the efficiency of a B-meson experiment.

  3. The optical trigger for beauty research, recent developments and perspectives

    NASA Astrophysics Data System (ADS)

    Giomataris, Y.; Perroud, J.-P.; Tran, M. T.; Chipaux, R.; Derré, J.; Kochowski, C.; Loucatos, S.; Rebourgeard, Ph.

    1992-02-01

    An optical detector sensitive to impact parameter has been tested in a particle beam. The device is based on the detection of Čerenkov light produced and trapped in a thin spherical crystal shell viewed by a fast photodetector. The detector is only sensitive to charged particles with a non-zero impact parameter relative to the center of the crystal sphere. A prototype using a LiF 3 mm thick crystal has been tested and the experimental results are in agreement with the expectations. We discuss applications of this detector for fast selection of B-events in fixed target experiments at proton accelerators. A program of technical development has started, aiming at a high efficiency in B-meson pairs and a rejection factor of 100 against unwanted minimum bias events. We also present a modified collider configuration, the Asymmetric Tilted Collider, to optimize the sensitivity and the efficiency of a B-meson experiment.

  4. (Research in elementary particles and interactions). [1992

    SciTech Connect

    Adair, R.; Sandweiss, J.; Schmidt, M.

    1992-05-01

    Research of the Yale University groups in the areas of elementary particles and their interactions are outlined. Work on the following topics is reported: development of CDF trigger system; SSC detector development; study of heavy flavors at TPL; search for composite objects produced in relativistic heavy-ion collisions; high-energy polarized lepton-nucleon scattering; rare K{sup +} decays; unpolarized high-energy muon scattering; muon anomalous magnetic moment; theoretical high-energy physics including gauge theories, symmetry breaking, string theory, and gravitation theory; study of e{sup +}e{sup {minus}} interactions with the SLD detector at SLAC; and the production and decay of particles containing charm and beauty quarks.

  5. Anthropometric comparison of painting portraits of beautiful women, femme fatales, and artists' mothers.

    PubMed

    Park, Ju Yong; Hwang, Se Won; Hwang, Kun

    2013-11-01

    The aim of this study was to compare the painting portraits of beautiful women, femme fatales, and artists' mothers using anthropometry.Portraits of each theme were selected in modern novels, essays and picture books, and categorized portraits. A total of 52 samples were collected, including 20 beautiful women, 20 femme fatales, and 12 artists' mothers. In 5 persons, 17 anthropometric ratios including the alae-alae/zygion-zygion ratio were compared in a 15-degree oblique view and in anteroposterior view photographs, and they were proved to not differ significantly. To distinguish oblique portraits less than 15 degrees, we measured the exocanthion-stomion-exocanthion (ESE) angle in photographs of 5 volunteers. The mean ± SD of the ESE angle was 64.52 ± 4.87 in the 15-degree angle view and 57.68 ± 54.09 in the 30-degree angle view. Thereafter, if the ESE angle was greater than 65 degrees, we considered the portrait to have less than a 15-degree angle and included it in the samples.The ratio did not differ significantly in 11 anthropometric proportions. However, the remaining 5 proportions were statistically significant. Beautiful women had wider noses (85% of the endocanthion-endocanthion width) than those of the femme fatale group (77%). Lips in the beautiful woman group are nicer and thicker (36% of lip's width) compared with the artists' mother group (27%). Femme fatales were relatively similar to beautiful women such as those women with nice and thick lips. However, the femme fatale group had an attractive midface ratio (36% of the total face height) that has been mentioned in the older literature, and the noses of the femme fatale group were narrower and sharper (77% of the endocanthion-endocanthion width) than those of the beautiful women (85%). The artists' mother group has a relatively narrower upper face (29% of the total face height) and thinner lips (27% of the lip width) compared with the other 2 groups (36%).Proportions from works of art are more

  6. The beauty of Enceladus: a possible life origin

    NASA Astrophysics Data System (ADS)

    de Morais Mendonca Teles, Antonio

    variations. One can consider that the rate state of biogeochemical evolution is directly related to the production of energy inside a planetary body with liquid water. The present state of this cold moon possibly can be analogue to that on Earth 4 Gyrs ago. So, I also propose that harmonious reactions between organic species, including mono-saccharides, can have formed replicant catalytic proteins and other biomolecules within warm water deep inside those possible subsurface lakes and ponds, leading to a hypothetical future biogeochemical evolution inside this beautiful moon Enceladus, which is interesting to the field of astrobiology.

  7. Particle separation

    DOEpatents

    Moosmuller, Hans; Chakrabarty, Rajan K.; Arnott, W. Patrick

    2011-04-26

    Embodiments of a method for selecting particles, such as based on their morphology, is disclosed. In a particular example, the particles are charged and acquire different amounts of charge, or have different charge distributions, based on their morphology. The particles are then sorted based on their flow properties. In a specific example, the particles are sorted using a differential mobility analyzer, which sorts particles, at least in part, based on their electrical mobility. Given a population of particles with similar electrical mobilities, the disclosed process can be used to sort particles based on the net charge carried by the particle, and thus, given the relationship between charge and morphology, separate the particles based on their morphology.

  8. Particle separation

    NASA Technical Reports Server (NTRS)

    Moosmuller, Hans (Inventor); Chakrabarty, Rajan K. (Inventor); Arnott, W. Patrick (Inventor)

    2011-01-01

    Embodiments of a method for selecting particles, such as based on their morphology, is disclosed. In a particular example, the particles are charged and acquire different amounts of charge, or have different charge distributions, based on their morphology. The particles are then sorted based on their flow properties. In a specific example, the particles are sorted using a differential mobility analyzer, which sorts particles, at least in part, based on their electrical mobility. Given a population of particles with similar electrical mobilities, the disclosed process can be used to sort particles based on the net charge carried by the particle, and thus, given the relationship between charge and morphology, separate the particles based on their morphology.

  9. Beauty and ugliness in the bodies and faces of others: an fMRI study of person esthetic judgement.

    PubMed

    Martín-Loeches, M; Hernández-Tamames, J A; Martín, A; Urrutia, M

    2014-09-26

    Whether beauty and ugliness represent two independent judgement categories or, instead, opposite extremes of a single dimension is a matter of debate. In the present 3T-functional Magnetic Resonance Imaging (fMRI) study, 20 participants were scanned while judging faces and nude bodies of people classified as extremely ugly, extremely beautiful, or indifferent. Certain areas, such as the caudate/nucleus accumbens (NAcc) and the anterior cingulate cortex (ACC), exhibited a linear relationship across esthetic judgments supporting ugliness as the lowest extreme of a beauty continuum. Other regions, such as basal occipital areas, displayed an inverse pattern, with the highest activations for ugly and the lowest for beautiful ones. Further, several areas were involved alike by both the very beautiful and the very ugly stimuli. Among these, the medial orbitofrontal cortex (mOFC), as well as the posterior and medial portions of the cingulate gyrus. This is interpreted as the activation of neural circuits related to self- vs. other-assessment. Beauty and ugliness in the brain, at least in relation to natural and biologically and socially relevant stimuli (faces and bodies), appear tightly related and non-independent. Finally, neutral stimuli elicited strong and wide activations of the somatosensory and somatomotor systems together with longer reaction times and higher error rates, probably reflecting the difficulty of the human brain to classify someone as indifferent. PMID:25086316

  10. Boosting beauty in an economic decline: mating, spending, and the lipstick effect.

    PubMed

    Hill, Sarah E; Rodeheffer, Christopher D; Griskevicius, Vladas; Durante, Kristina; White, Andrew Edward

    2012-08-01

    Although consumer spending typically declines in economic recessions, some observers have noted that recessions appear to increase women's spending on beauty products--the so-called lipstick effect. Using both historical spending data and rigorous experiments, the authors examine how and why economic recessions influence women's consumer behavior. Findings revealed that recessionary cues--whether naturally occurring or experimentally primed--decreased desire for most products (e.g., electronics, household items). However, these cues consistently increased women's desire for products that increase attractiveness to mates--the first experimental demonstration of the lipstick effect. Additional studies show that this effect is driven by women's desire to attract mates with resources and depends on the perceived mate attraction function served by these products. In addition to showing how and why economic recessions influence women's desire for beauty products, this research provides novel insights into women's mating psychology, consumer behavior, and the relationship between the two. PMID:22642483

  11. The world can look better: enhancing beauty experience with brain stimulation

    PubMed Central

    Lega, Carlotta; Flexas, Albert; Nadal, Marcos; Munar, Enric; Cela-Conde, Camilo J.

    2014-01-01

    Aesthetic appreciation is part of our everyday life: it is a subjective judgment we make when looking at a painting, a landscape, or—in fact—at another person. Neuroimaging and electrophysiological evidence suggests that the left dorsolateral prefrontal cortex (DLPFC) plays a critical role in aesthetic judgments. Here, we show that the experience of beauty can be artificially enhanced with brain stimulation. Specifically, we show that aesthetic appreciation of representational paintings and photographs can be increased by applying anodal (excitatory) transcranial direct current stimulation on the left DLPFC. Our results thus show that beauty is in the brain of the beholder, and offer a novel view on the neural networks underlying aesthetic appreciation. PMID:24132459

  12. The world can look better: enhancing beauty experience with brain stimulation.

    PubMed

    Cattaneo, Zaira; Lega, Carlotta; Flexas, Albert; Nadal, Marcos; Munar, Enric; Cela-Conde, Camilo J

    2014-11-01

    Aesthetic appreciation is part of our everyday life: it is a subjective judgment we make when looking at a painting, a landscape, or--in fact--at another person. Neuroimaging and electrophysiological evidence suggests that the left dorsolateral prefrontal cortex (DLPFC) plays a critical role in aesthetic judgments. Here, we show that the experience of beauty can be artificially enhanced with brain stimulation. Specifically, we show that aesthetic appreciation of representational paintings and photographs can be increased by applying anodal (excitatory) transcranial direct current stimulation on the left DLPFC. Our results thus show that beauty is in the brain of the beholder, and offer a novel view on the neural networks underlying aesthetic appreciation. PMID:24132459

  13. Body weight and beauty: the changing face of the ideal female body weight.

    PubMed

    Bonafini, B A; Pozzilli, P

    2011-01-01

    By observing the art of different eras, as well as the more recent existence of the media, it is obvious that there have been dramatic changes in what is considered a beautiful body. The ideal of female beauty has shifted from a symbol of fertility to one of mathematically calculated proportions. It has taken the form of an image responding to men's sexual desires. Nowadays there seems to be a tendency towards the destruction of the feminine, as androgynous fashion and appearance dominate our culture. The metamorphosis of the ideal woman follows the shifting role of women in society from mother and mistress to a career-orientated individual. Her depiction by artists across the centuries reveals this change in role and appearance that should be interpreted within the social and historical context of each era with its own theories of what constituted the ideal female body weight. PMID:20492540

  14. The ethical complexities of online organ solicitation via donor-patient websites: avoiding the "beauty contest".

    PubMed

    Neidich, E M; Neidich, A B; Cooper, J T; Bramstedt, K A

    2012-01-01

    The proliferation of the Internet has spurred the creation of websites dedicated to facilitating living directed organ donations. We argue that such sites potentially devolve into "beauty contests" where patients in need are evaluated on the basis of their personal appearance and biography-variables which should have no relevance to organ allocation. Altruism should be the guiding motivation for all donations, and when it does, there is no place for a beauty contest. The power of the Internet is optimally used when it facilitates Good Samaritan donations-donations to any stranger, rather than handpicked ones. Social networking sites which aim to match potential donors and patients should mask personal identifying information, allowing the ethical principles of altruism and justice to guide organ allocation. PMID:21951635

  15. Cultural representations of thinness in women, redux: Playboy magazine's depiction of beauty from 1979 to 1999.

    PubMed

    Sypeck, Mia Foley; Gray, James J; Etu, Sarah F; Ahrens, Anthony H; Mosimann, James E; Wiseman, Claire V

    2006-09-01

    Playboy's portrayal of the male ideal of feminine beauty, in terms of overall body size, percent normative weight, and waist-to-hip ratios (WHRs), was analyzed for the years 1979-1999. Trends were examined through body measurements obtained from Playboy centerfolds. Results reveal a continuation of the low body mass index (BMI) found in the Playmates by earlier studies; however, for the 21 years examined, the trend towards increasing thinness seems to have stabilized and may have begun to actually reverse. There was also an increase in the centerfolds' WHRs over the 21-year time period. Overall, the results support the continued valuing in American society of a thin ideal for women; while the images of beauty have become somewhat heavier over the 21-year period reviewed, the Playmates remain markedly below weights normative for their age group. PMID:18089225

  16. The skin health and beauty pyramid: a clinically based guide to selecting topical skincare products.

    PubMed

    Mayoral, Flor A; Kenner, Julie R; Draelos, Zoe Diana

    2014-04-01

    The use of cosmeceuticals by patients is now commonplace. Without consultation and direction from an informed clinician, marketing pressures can lead consumers to make poor product choices that can result in wasted money and unsatisfactory outcomes. Skin professionals need a scientifically based, succinct tool to guide their patients toward best topical skincare practices. The Skin Health and Beauty Pyramid is an educational framework and product guide created from extensive scientific literature and study review on ingredients, formulations and technologies affecting skin biology. This clinical tool can simplify product choices for physicians and clinicians in the process of professionally guiding patients toward the optimal use of topical products to achieve best outcomes for skin health and beauty. PMID:24719060

  17. Sleeping Beauty transposon system for genetic etiological research and gene therapy of cancers.

    PubMed

    Hou, Xiaomei; Du, Yan; Deng, Yang; Wu, Jianfeng; Cao, Guangwen

    2015-01-01

    Carcinogenesis is etiologically associated with somatic mutations of critical genes. Recently, a number of somatic mutations and key molecules have been found to be involved in functional networks affecting cancer progression. Suitable animal models are required to validate cancer-promoting or -inhibiting capacities of these mutants and molecules. Sleeping Beauty transposon system consists of a transposon that carries gene(s) of interest and a transposase that recognizes, excises, and reinserts genes in given location of the genome. It can create both gain-of-function and loss-of-function mutations, thus being frequently chosen to investigate the etiological mechanisms and gene therapy for cancers in animal models. In this review, we summarized current advances of Sleeping Beauty transposon system in revealing molecular mechanism of cancers and improving gene therapy. Understanding molecular mechanisms by which driver mutations contribute to carcinogenesis and metastasis may pave the way for the development of innovative prophylactic and therapeutic strategies against malignant diseases. PMID:25455252

  18. Big and beautiful? Evidence of racial differences in the perceived attractiveness of obese females.

    PubMed

    Ali, Mir M; Rizzo, John A; Heiland, Frank W

    2013-06-01

    This paper investigates the relationships between body weight, race, and attractiveness in appearance and personality among adolescents. We study a sample of 5947 (non-Hispanic) white and black girls age 12 to 18 who were interviewed by a group of 338 interviewers. We find that overweight and obese white female adolescents are, respectively, 23% and 40% less likely, on average, to be perceived as physically attractive compared to normal-weight white girls. The physical appearance penalties are significantly smaller for overweight and obese black girls compared to white girls. These findings suggest that being overweight or obese is costly due to its negative impact on inner and outer perceived beauty, providing an explanation for the observed stigmatization of overweight and obesity among women in labor and relationship markets. The smaller beauty penalties for black girls above the normal-weight range suggest that the range of body sizes considered attractive may be wider for black females. PMID:23591377

  19. Sleeping Beauty transposon system for genetic etiological research and gene therapy of cancers

    PubMed Central

    Hou, Xiaomei; Du, Yan; Deng, Yang; Wu, Jianfeng; Cao, Guangwen

    2015-01-01

    Carcinogenesis is etiologically associated with somatic mutations of critical genes. Recently, a number of somatic mutations and key molecules have been found to be involved in functional networks affecting cancer progression. Suitable animal models are required to validate cancer-promoting or -inhibiting capacities of these mutants and molecules. Sleeping Beauty transposon system consists of a transposon that carries gene(s) of interest and a transposase that recognizes, excises, and reinserts genes in given location of the genome. It can create both gain-of-function and loss-of-function mutations, thus being frequently chosen to investigate the etiological mechanisms and gene therapy for cancers in animal models. In this review, we summarized current advances of Sleeping Beauty transposon system in revealing molecular mechanism of cancers and improving gene therapy. Understanding molecular mechanisms by which driver mutations contribute to carcinogenesis and metastasis may pave the way for the development of innovative prophylactic and therapeutic strategies against malignant diseases. PMID:25455252

  20. Dedication to Degradation: The Beauty of Materials Designed to Lay in Ruin

    NASA Astrophysics Data System (ADS)

    Nychka, John A.; Kruzic, Jaime

    2014-04-01

    Degradation of materials is typically perceived to be a negative response in service. Many designs, and materials, have been and are ruined due to corrosion, fatigue, weathering, ultraviolet light, fungal attack, bacterial attack, erosion, wear, electromigration… and on the list goes. However, the carefully controlled and purposeful degradation of materials is a prerequisite for success for some designs—and such ability is a beautiful necessity when it comes to many regenerative biomaterials. In other instances, we must seek first to understand the degradation mechanisms before we can achieve degradation prevention—and the resistance of some materials to degradation is also beautiful. Regardless of whether we try to prevent or elicit degradation, our dedication to degradation of materials is ever present in materials design.

  1. Beauty-quark and charm-quark pair production asymmetries at LHCb

    NASA Astrophysics Data System (ADS)

    Gauld, Rhorry; Haisch, Ulrich; Pecjak, Ben D.; Re, Emanuele

    2015-08-01

    The LHCb Collaboration has recently performed a first measurement of the angular production asymmetry in the distribution of beauty quarks and antiquarks at a hadron collider. We calculate the corresponding standard model prediction for this asymmetry at fixed order in perturbation theory. Our results show good agreement with the data, which are provided differentially for three bins in the invariant mass of the b b ¯ system. We also present similar predictions for both beauty-quark and charm-quark final states within the LHCb acceptance for a collision energy of √{s }=13 TeV . We finally point out that a measurement of the ratio of the b b ¯ and c c ¯ cross sections may be useful for experimentally validating charm-tagging efficiencies.

  2. Beauty, body size and wages: Evidence from a unique data set.

    PubMed

    Oreffice, Sonia; Quintana-Domeque, Climent

    2016-09-01

    We analyze how attractiveness rated at the start of the interview in the German General Social Survey is related to weight, height, and body mass index (BMI), separately by gender and accounting for interviewers' characteristics or fixed effects. We show that height, weight, and BMI all strongly contribute to male and female attractiveness when attractiveness is rated by opposite-sex interviewers, and that anthropometric characteristics are irrelevant to male interviewers when assessing male attractiveness. We also estimate whether, controlling for beauty, body size measures are related to hourly wages. We find that anthropometric attributes play a significant role in wage regressions in addition to attractiveness, showing that body size cannot be dismissed as a simple component of beauty. Our findings are robust to controlling for health status and accounting for selection into working. PMID:27015611

  3. "The Corn People Have a Song Too. It Is Very Good": On Beauty, Truth, and Goodness

    ERIC Educational Resources Information Center

    Chamberlin, J. Edward

    2009-01-01

    Twenty-first-century skeptics would say that there are really no such things as beauty and truth and certainly not goodness. A Pueblo poet seemed to think there was--"the corn people have a song / it is very good"--and unless people think they know better, they'd better listen up. This article begins with a short piece, set down by the…

  4. Beauty production cross section measurements at E(cm) = 1.96-TeV

    SciTech Connect

    D'Onofrio, Monica; /Geneva U.

    2005-05-01

    The RunII physics program at the Tevatron started in spring 2001 with protons and antiprotons colliding at an energy of {radical}s = 1.96 TeV, and it is carrying on with more than 500 pb{sup -1} of data as collected by both the CDF and D0 experiments. Recent results on beauty production cross section measurements are here reported.

  5. An analysis and retrofit of the acoustics at Image Creators Health and Beauty Salon

    NASA Astrophysics Data System (ADS)

    Ellis, Donna

    2002-11-01

    This paper discusses the analysis and retrofit of the acoustics in a high-volume beauty salon in Severna Park, MD. The major issues in what was designed to be a serene environment are reverberation times of 1-1.68 s in the mid- to upper-frequency range. Employee and customer complaints include heightened stress, vocal strain, headaches, and poor intelligibility. Existing analysis and acoustical retrofit solutions will be demonstrated.

  6. Beauty matters: social preferences in a three-person ultimatum game.

    PubMed

    Ma, Qingguo; Hu, Yue

    2015-01-01

    Preference for beauty is human nature, as previous behavior studies have supported the notion of "beauty premium" in which attractive people were more easily to get promoted and receive higher salaries. In the present study, 29 males were recruited to participate in a three-person ultimatum game (UG) including a proposer, a responder and a powerless third player. Each subject, playing as the responder, had to decide whether to accept an offer from the allocator both for himself and a female third person. We aimed to elucidate how the facial attractiveness of the female subject affected the male subjects' fairness and decision-making in social exchanges. Frontal feedback-related negativity (FRN) in response to four offers in an attractive-face condition revealed no significant differences between offers; however, when the companion was an unattractive female, an "unfair/fair" offer, which assigned a lower share to the responder and a fair share to the third player, elicited the largest FRN. Furthermore, when the third player was offered the smallest amount ("fair/unfair" offer), a larger FRN was generated in an attractive-face condition than unattractive-face condition. In the "unfair/fair" offer condition in which subjects received a smaller allocation than the third person, the beauty of their female counterparts attenuated subjects' aversion to inequality, resulting in a less negative FRN in the frontal region and an increased acceptance ratio. However, the influence of the third player's facial attractiveness only affected the early evaluation stage: late P300 was found to be immune to the "beauty premium". Under the two face conditions, P300 was smallest following an "unfair/fair" offer, whereas the amplitudes in the other three offer conditions exhibited no significant differences. In addition, the differentiated neural features of processing facial attractiveness were also determined and indexed by four event-related potentials (ERP) components: N170, frontal

  7. The Accelerating Universe: Infinite Expansion, the Cosmological Constant, and the Beauty of the Cosmos

    NASA Astrophysics Data System (ADS)

    Livio, Mario

    2000-12-01

    Advance Praise for The Accelerating Universe "The Accelerating Universe is not only an informative book about modern cosmology. It is rich storytelling and, above all, a celebration of the human mind in its quest for beauty in all things." -Alan Lightman, author of Einstein's Dreams "This is a wonderfully lucid account of the extraordinary discoveries that have made the last years a golden period for observational cosmology. But Mario Livio has not only given the reader one clear explanation after another of what astronomers are up to, he has used them to construct a provocative argument for the importance of aesthetics in the development of science and for the inseparability of science, art, and culture." -Lee Smolin, author of The Life of the Cosmos "What a pleasure to read! An exciting, simple account of the universe revealed by modern astronomy. Beautifully written, clearly presented, informed by scientific and philosophical insights." -John Bahcall, Institute for Advanced Study "A book with charm, beauty, elegance, and importance. As authoritative a journey as can be taken through modern cosmology." -Allan Sandage, Observatories of the Carnegie Institution of Washington

  8. Preliminary geologic map of the Beautiful Mountain anticline, San Juan County, New Mexico

    USGS Publications Warehouse

    Beaumont, E.C.

    1954-01-01

    The Beautiful Mountain anticline is on the Navajo Indian Reservation in western San Juan County, N. Mex., near the Arizona-New Mexico State line; it lies along tbe western side of the Chuska Valley at the foot of the Chuska Mountains. Most of the area of this report is characterized by low, sharp relief. Beautiful Mountain, a buttelike outlier of the Chuska Mountains, contrasts strikingly with the otherwise low relief of the area--it rises above the western flank of the anticline to an alutude of nearly 9,000 feet. The general form of the partly breached anticlinal structure is expressed in the topography sharply delineated cuestas, mesas, buttes, and promontories, all capped by the resistant sandstone beds of the Tocito sandstone lentil of rhe Mancos shale. This report shows the distribution and thickness of the sedimentary rocks exposed in the area of the Beautiful Mountain anticline and the conformation of the anticline as represented by structure contours drawn on the top of the Dakota sandstone.

  9. Comparison of lentiviral and sleeping beauty mediated αβ T cell receptor gene transfer.

    PubMed

    Field, Anne-Christine; Vink, Conrad; Gabriel, Richard; Al-Subki, Roua; Schmidt, Manfred; Goulden, Nicholas; Stauss, Hans; Thrasher, Adrian; Morris, Emma; Qasim, Waseem

    2013-01-01

    Transfer of tumour antigen-specific receptors to T cells requires efficient delivery and integration of transgenes, and currently most clinical studies are using gamma retroviral or lentiviral systems. Whilst important proof-of-principle data has been generated for both chimeric antigen receptors and αβ T cell receptors, the current platforms are costly, time-consuming and relatively inflexible. Alternative, more cost-effective, Sleeping Beauty transposon-based plasmid systems could offer a pathway to accelerated clinical testing of a more diverse repertoire of recombinant high affinity T cell receptors. Nucleofection of hyperactive SB100X transposase-mediated stable transposition of an optimised murine-human chimeric T cell receptor specific for Wilm's tumour antigen from a Sleeping Beauty transposon plasmid. Whilst transfer efficiency was lower than that mediated by lentiviral transduction, cells could be readily enriched and expanded, and mediated effective target cells lysis in vitro and in vivo. Integration sites of transposed TCR genes in primary T cells were almost randomly distributed, contrasting the predilection of lentiviral vectors for transcriptionally active sites. The results support exploitation of the Sleeping Beauty plasmid based system as a flexible and adaptable platform for accelerated, early-phase assessment of T cell receptor gene therapies. PMID:23840834

  10. Semileptonic decays of charmed and beauty baryons with heavy sterile neutrinos in the final state

    SciTech Connect

    Ramazanov, Sabir

    2009-04-01

    We obtain tree-level estimates of various differential branching ratios of heavy baryon decays with massive sterile neutrinos {nu}{sub x} in the final state. Generally, charmed baryons are found to be less promising than charmed mesons, in contrast to b hadrons. In the latter case, branching ratios of beauty mesons and baryons into sterile neutrinos are of the same order. As a consequence, at high energies beauty baryons give contribution to sterile neutrino production comparable to the contribution of beauty mesons (up to about 15%). Experimental limits on active-to-sterile mixing are quite strong for neutrinos lighter than D mesons but for heavier neutrinos they are weaker. As an example, for neutrino masses in the range 2 GeV < or approx. m{sub {nu}{sub x}} < or approx. 2.5 GeV, current data imply that the bounds on {lambda}{sub b}-hyperon branching ratios into sterile neutrinos are Br({lambda}{sub b}{yields}{lambda}{sub c}+e{sup -}+{nu}{sub x}) < or approx. 1.3x10{sup -5}-1.7x10{sup -6} and Br({lambda}{sub b}{yields}{lambda}{sub c}+{mu}{sup -}+{nu}{sub x}) < or approx. 3.9x10{sup -7}-1.4x10{sup -7}.

  11. Genetic Signature of Histiocytic Sarcoma Revealed by a Sleeping Beauty Transposon Genetic Screen in Mice

    PubMed Central

    Been, Raha A.; Linden, Michael A.; Hager, Courtney J.; DeCoursin, Krista J.; Abrahante, Juan E.; Landman, Sean R.; Steinbach, Michael; Sarver, Aaron L.; Largaespada, David A.; Starr, Timothy K.

    2014-01-01

    Histiocytic sarcoma is a rare, aggressive neoplasm that responds poorly to therapy. Histiocytic sarcoma is thought to arise from macrophage precursor cells via genetic changes that are largely undefined. To improve our understanding of the etiology of histiocytic sarcoma we conducted a forward genetic screen in mice using the Sleeping Beauty transposon as a mutagen to identify genetic drivers of histiocytic sarcoma. Sleeping Beauty mutagenesis was targeted to myeloid lineage cells using the Lysozyme2 promoter. Mice with activated Sleeping Beauty mutagenesis had significantly shortened lifespan and the majority of these mice developed tumors resembling human histiocytic sarcoma. Analysis of transposon insertions identified 27 common insertion sites containing 28 candidate cancer genes. Several of these genes are known drivers of hematological neoplasms, like Raf1, Fli1, and Mitf, while others are well-known cancer genes, including Nf1, Myc, Jak2, and Pten. Importantly, several new potential drivers of histiocytic sarcoma were identified and could serve as targets for therapy for histiocytic sarcoma patients. PMID:24827933

  12. Comparison of Lentiviral and Sleeping Beauty Mediated αβ T Cell Receptor Gene Transfer

    PubMed Central

    Field, Anne-Christine; Vink, Conrad; Gabriel, Richard; Al-Subki, Roua; Schmidt, Manfred; Goulden, Nicholas; Stauss, Hans; Thrasher, Adrian; Morris, Emma; Qasim, Waseem

    2013-01-01

    Transfer of tumour antigen-specific receptors to T cells requires efficient delivery and integration of transgenes, and currently most clinical studies are using gamma retroviral or lentiviral systems. Whilst important proof-of-principle data has been generated for both chimeric antigen receptors and αβ T cell receptors, the current platforms are costly, time-consuming and relatively inflexible. Alternative, more cost-effective, Sleeping Beauty transposon-based plasmid systems could offer a pathway to accelerated clinical testing of a more diverse repertoire of recombinant high affinity T cell receptors. Nucleofection of hyperactive SB100X transposase-mediated stable transposition of an optimised murine-human chimeric T cell receptor specific for Wilm’s tumour antigen from a Sleeping Beauty transposon plasmid. Whilst transfer efficiency was lower than that mediated by lentiviral transduction, cells could be readily enriched and expanded, and mediated effective target cells lysis in vitro and in vivo. Integration sites of transposed TCR genes in primary T cells were almost randomly distributed, contrasting the predilection of lentiviral vectors for transcriptionally active sites. The results support exploitation of the Sleeping Beauty plasmid based system as a flexible and adaptable platform for accelerated, early-phase assessment of T cell receptor gene therapies. PMID:23840834

  13. First Measurement of the Charge Asymmetry in Beauty-Quark Pair Production

    NASA Astrophysics Data System (ADS)

    Aaij, R.; Adeva, B.; Adinolfi, M.; Affolder, A.; Ajaltouni, Z.; Akar, S.; Albrecht, J.; Alessio, F.; Alexander, M.; Ali, S.; Alkhazov, G.; Alvarez Cartelle, P.; Alves, A. A.; Amato, S.; Amerio, S.; Amhis, Y.; An, L.; Anderlini, L.; Anderson, J.; Andreassen, R.; Andreotti, M.; Andrews, J. E.; Appleby, R. B.; Aquines Gutierrez, O.; Archilli, F.; Artamonov, A.; Artuso, M.; Aslanides, E.; Auriemma, G.; Baalouch, M.; Bachmann, S.; Back, J. J.; Badalov, A.; Balagura, V.; Baldini, W.; Barlow, R. J.; Barschel, C.; Barsuk, S.; Barter, W.; Batozskaya, V.; Battista, V.; Bay, A.; Beaucourt, L.; Beddow, J.; Bedeschi, F.; Bediaga, I.; Belogurov, S.; Belous, K.; Belyaev, I.; Ben-Haim, E.; Bencivenni, G.; Benson, S.; Benton, J.; Berezhnoy, A.; Bernet, R.; Bettler, M.-O.; van Beuzekom, M.; Bien, A.; Bifani, S.; Bird, T.; Bizzeti, A.; Bjørnstad, P. M.; Blake, T.; Blanc, F.; Blouw, J.; Blusk, S.; Bocci, V.; Bondar, A.; Bondar, N.; Bonivento, W.; Borghi, S.; Borgia, A.; Borsato, M.; Bowcock, T. J. V.; Bowen, E.; Bozzi, C.; Brambach, T.; van den Brand, J.; Bressieux, J.; Brett, D.; Britsch, M.; Britton, T.; Brodzicka, J.; Brook, N. H.; Brown, H.; Bursche, A.; Busetto, G.; Buytaert, J.; Cadeddu, S.; Calabrese, R.; Calvi, M.; Calvo Gomez, M.; Camboni, A.; Campana, P.; Campora Perez, D.; Carbone, A.; Carboni, G.; Cardinale, R.; Cardini, A.; Carranza-Mejia, H.; Carson, L.; Carvalho Akiba, K.; Casse, G.; Cassina, L.; Castillo Garcia, L.; Cattaneo, M.; Cauet, Ch.; Cenci, R.; Charles, M.; Charpentier, Ph.; Chen, S.; Cheung, S.-F.; Chiapolini, N.; Chrzaszcz, M.; Ciba, K.; Cid Vidal, X.; Ciezarek, G.; Clarke, P. E. L.; Clemencic, M.; Cliff, H. V.; Closier, J.; Coco, V.; Cogan, J.; Cogneras, E.; Collins, P.; Comerma-Montells, A.; Contu, A.; Cook, A.; Coombes, M.; Coquereau, S.; Corti, G.; Corvo, M.; Counts, I.; Couturier, B.; Cowan, G. A.; Craik, D. C.; Cruz Torres, M.; Cunliffe, S.; Currie, R.; D'Ambrosio, C.; Dalseno, J.; David, P.; David, P. N. Y.; Davis, A.; De Bruyn, K.; De Capua, S.; De Cian, M.; De Miranda, J. M.; De Paula, L.; De Silva, W.; De Simone, P.; Decamp, D.; Deckenhoff, M.; Del Buono, L.; Déléage, N.; Derkach, D.; Deschamps, O.; Dettori, F.; Di Canto, A.; Dijkstra, H.; Donleavy, S.; Dordei, F.; Dorigo, M.; Dosil Suárez, A.; Dossett, D.; Dovbnya, A.; Dreimanis, K.; Dujany, G.; Dupertuis, F.; Durante, P.; Dzhelyadin, R.; Dziurda, A.; Dzyuba, A.; Easo, S.; Egede, U.; Egorychev, V.; Eidelman, S.; Eisenhardt, S.; Eitschberger, U.; Ekelhof, R.; Eklund, L.; El Rifai, I.; Elsasser, Ch.; Ely, S.; Esen, S.; Evans, H.-M.; Evans, T.; Falabella, A.; Färber, C.; Farinelli, C.; Farley, N.; Farry, S.; Fay, RF; Ferguson, D.; Fernandez Albor, V.; Ferreira Rodrigues, F.; Ferro-Luzzi, M.; Filippov, S.; Fiore, M.; Fiorini, M.; Firlej, M.; Fitzpatrick, C.; Fiutowski, T.; Fontana, M.; Fontanelli, F.; Forty, R.; Francisco, O.; Frank, M.; Frei, C.; Frosini, M.; Fu, J.; Furfaro, E.; Gallas Torreira, A.; Galli, D.; Gallorini, S.; Gambetta, S.; Gandelman, M.; Gandini, P.; Gao, Y.; García Pardiñas, J.; Garofoli, J.; Garra Tico, J.; Garrido, L.; Gaspar, C.; Gauld, R.; Gavardi, L.; Gavrilov, G.; Gersabeck, E.; Gersabeck, M.; Gershon, T.; Ghez, Ph.; Gianelle, A.; Giani', S.; Gibson, V.; Giubega, L.; Gligorov, V. V.; Göbel, C.; Golubkov, D.; Golutvin, A.; Gomes, A.; Gordon, H.; Gotti, C.; Grabalosa Gándara, M.; Graciani Diaz, R.; Granado Cardoso, L. A.; Graugés, E.; Graziani, G.; Grecu, A.; Greening, E.; Gregson, S.; Griffith, P.; Grillo, L.; Grünberg, O.; Gui, B.; Gushchin, E.; Guz, Yu.; Gys, T.; Hadjivasiliou, C.; Haefeli, G.; Haen, C.; Haines, S. C.; Hall, S.; Hamilton, B.; Hampson, T.; Han, X.; Hansmann-Menzemer, S.; Harnew, N.; Harnew, S. T.; Harrison, J.; He, J.; Head, T.; Heijne, V.; Hennessy, K.; Henrard, P.; Henry, L.; Hernando Morata, J. A.; van Herwijnen, E.; Heß, M.; Hicheur, A.; Hill, D.; Hoballah, M.; Hombach, C.; Hulsbergen, W.; Hunt, P.; Hussain, N.; Hutchcroft, D.; Hynds, D.; Idzik, M.; Ilten, P.; Jacobsson, R.; Jaeger, A.; Jalocha, J.; Jans, E.; Jaton, P.; Jawahery, A.; Jing, F.; John, M.; Johnson, D.; Jones, C. R.; Joram, C.; Jost, B.; Jurik, N.; Kaballo, M.; Kandybei, S.; Kanso, W.; Karacson, M.; Karbach, T. M.; Karodia, S.; Kelsey, M.; Kenyon, I. R.; Ketel, T.; Khanji, B.; Khurewathanakul, C.; Klaver, S.; Klimaszewski, K.; Kochebina, O.; Kolpin, M.; Komarov, I.; Koopman, R. F.; Koppenburg, P.; Korolev, M.; Kozlinskiy, A.; Kravchuk, L.; Kreplin, K.; Kreps, M.; Krocker, G.; Krokovny, P.; Kruse, F.; Kucewicz, W.; Kucharczyk, M.; Kudryavtsev, V.; Kurek, K.; Kvaratskheliya, T.; La Thi, V. N.; Lacarrere, D.; Lafferty, G.; Lai, A.; Lambert, D.; Lambert, R. W.; Lanciotti, E.; Lanfranchi, G.; Langenbruch, C.; Langhans, B.; Latham, T.; Lazzeroni, C.; Le Gac, R.; van Leerdam, J.; Lees, J.-P.; Lefèvre, R.; Leflat, A.

    2014-08-01

    The difference in the angular distributions between beauty quarks and antiquarks, referred to as the charge asymmetry, is measured for the first time in bb¯ pair production at a hadron collider. The data used correspond to an integrated luminosity of 1.0 fb-1 collected at 7 TeV center-of-mass energy in proton-proton collisions with the LHCb detector. The measurement is performed in three regions of the invariant mass of the bb¯ system. The results obtained are ACbb¯(40105 GeV /c2)=1.6±1.7±0.6%, where ACbb¯ is defined as the asymmetry in the difference in rapidity between jets formed from the beauty quark and antiquark, where in each case the first uncertainty is statistical and the second systematic. The beauty jets are required to satisfy 2<η <4, ET>20 GeV, and have an opening angle in the transverse plane Δϕ >2.6 rad. These measurements are consistent with the predictions of the standard model.

  14. Sex-related similarities and differences in the neural correlates of beauty

    PubMed Central

    Cela-Conde, Camilo J.; Ayala, Francisco J.; Munar, Enric; Maestú, Fernando; Nadal, Marcos; Capó, Miguel A.; del Río, David; López-Ibor, Juan J.; Ortiz, Tomás; Mirasso, Claudio; Marty, Gisèle

    2009-01-01

    The capacity to appreciate beauty is one of our species' most remarkable traits. Although knowledge about its neural correlates is growing, little is known about any gender-related differences. We have explored possible differences between men and women's neural correlates of aesthetic preference. We have used magnetoencephalography to record the brain activity of 10 male and 10 female participants while they decided whether or not they considered examples of artistic and natural visual stimuli to be beautiful. Our results reveal significantly different activity between the sexes in parietal regions when participants judged the stimuli as beautiful. Activity in this region was bilateral in women, whereas it was lateralized to the right hemisphere in men. It is known that the dorsal visual processing stream, which encompasses the superior parietal areas, has been significantly modified throughout human evolution. We posit that the observed gender-related differences are the result of evolutionary processes that occurred after the splitting of the human and chimpanzee lineages. In view of previous results on gender differences with respect to the neural correlates of coordinate and categorical spatial strategies, we infer that the different strategies used by men and women in assessing aesthetic preference may reflect differences in the strategies associated with the division of labor between our male and female hunter-gatherer hominin ancestors. PMID:19237562

  15. The "beauty arch: " a new aesthetic analysis for malar augmentation planning.

    PubMed

    Marianetti, Tito Matteo; Cozzolino, Salvatore; Torroni, Andrea; Gasparini, Giulio; Pelo, Sandro

    2015-05-01

    Midface is a critical area for the aesthetics of the face. Despite malar hypoplasia is often combined with a class III malocclusion, there are few studies focusing on the results of a combined approach of malar implants and Le Fort I. We describe a new aesthetic analysis, named "beauty arch" analysis, for the assessment of sagittal projection of the malar region. We took a reference group of 74 Italian women participating in a national beauty contest in 2011 on which we performed our analysis. We used the ideal values to elaborate the surgical treatment planning of a second group of 45 consecutive female patients affected by skeletal class III malocclusion.Twenty-three patients undergo simultaneous Le Fort I osteotomy and malar implants. From the descriptive statistical comparison of the patients' values before and after orthognathic surgery and malar implants with the reference values, we observed how all parameters considered got closer to the ideal population. We consider our beauty arch a useful help for surgeon in the treatment planning of patients with skeletal malocclusions and malar implants. PMID:25974765

  16. First measurement of the charge asymmetry in beauty-quark pair production.

    PubMed

    Aaij, R; Adeva, B; Adinolfi, M; Affolder, A; Ajaltouni, Z; Akar, S; Albrecht, J; Alessio, F; Alexander, M; Ali, S; Alkhazov, G; Alvarez Cartelle, P; Alves, A A; Amato, S; Amerio, S; Amhis, Y; An, L; Anderlini, L; Anderson, J; Andreassen, R; Andreotti, M; Andrews, J E; Appleby, R B; Aquines Gutierrez, O; Archilli, F; Artamonov, A; Artuso, M; Aslanides, E; Auriemma, G; Baalouch, M; Bachmann, S; Back, J J; Badalov, A; Balagura, V; Baldini, W; Barlow, R J; Barschel, C; Barsuk, S; Barter, W; Batozskaya, V; Battista, V; Bay, A; Beaucourt, L; Beddow, J; Bedeschi, F; Bediaga, I; Belogurov, S; Belous, K; Belyaev, I; Ben-Haim, E; Bencivenni, G; Benson, S; Benton, J; Berezhnoy, A; Bernet, R; Bettler, M-O; van Beuzekom, M; Bien, A; Bifani, S; Bird, T; Bizzeti, A; Bjørnstad, P M; Blake, T; Blanc, F; Blouw, J; Blusk, S; Bocci, V; Bondar, A; Bondar, N; Bonivento, W; Borghi, S; Borgia, A; Borsato, M; Bowcock, T J V; Bowen, E; Bozzi, C; Brambach, T; van den Brand, J; Bressieux, J; Brett, D; Britsch, M; Britton, T; Brodzicka, J; Brook, N H; Brown, H; Bursche, A; Busetto, G; Buytaert, J; Cadeddu, S; Calabrese, R; Calvi, M; Calvo Gomez, M; Camboni, A; Campana, P; Campora Perez, D; Carbone, A; Carboni, G; Cardinale, R; Cardini, A; Carranza-Mejia, H; Carson, L; Carvalho Akiba, K; Casse, G; Cassina, L; Castillo Garcia, L; Cattaneo, M; Cauet, Ch; Cenci, R; Charles, M; Charpentier, Ph; Chen, S; Cheung, S-F; Chiapolini, N; Chrzaszcz, M; Ciba, K; Cid Vidal, X; Ciezarek, G; Clarke, P E L; Clemencic, M; Cliff, H V; Closier, J; Coco, V; Cogan, J; Cogneras, E; Collins, P; Comerma-Montells, A; Contu, A; Cook, A; Coombes, M; Coquereau, S; Corti, G; Corvo, M; Counts, I; Couturier, B; Cowan, G A; Craik, D C; Cruz Torres, M; Cunliffe, S; Currie, R; D'Ambrosio, C; Dalseno, J; David, P; David, P N Y; Davis, A; De Bruyn, K; De Capua, S; De Cian, M; De Miranda, J M; De Paula, L; De Silva, W; De Simone, P; Decamp, D; Deckenhoff, M; Del Buono, L; Déléage, N; Derkach, D; Deschamps, O; Dettori, F; Di Canto, A; Dijkstra, H; Donleavy, S; Dordei, F; Dorigo, M; Dosil Suárez, A; Dossett, D; Dovbnya, A; Dreimanis, K; Dujany, G; Dupertuis, F; Durante, P; Dzhelyadin, R; Dziurda, A; Dzyuba, A; Easo, S; Egede, U; Egorychev, V; Eidelman, S; Eisenhardt, S; Eitschberger, U; Ekelhof, R; Eklund, L; El Rifai, I; Elsasser, Ch; Ely, S; Esen, S; Evans, H-M; Evans, T; Falabella, A; Färber, C; Farinelli, C; Farley, N; Farry, S; Fay, Rf; Ferguson, D; Fernandez Albor, V; Ferreira Rodrigues, F; Ferro-Luzzi, M; Filippov, S; Fiore, M; Fiorini, M; Firlej, M; Fitzpatrick, C; Fiutowski, T; Fontana, M; Fontanelli, F; Forty, R; Francisco, O; Frank, M; Frei, C; Frosini, M; Fu, J; Furfaro, E; Gallas Torreira, A; Galli, D; Gallorini, S; Gambetta, S; Gandelman, M; Gandini, P; Gao, Y; García Pardiñas, J; Garofoli, J; Garra Tico, J; Garrido, L; Gaspar, C; Gauld, R; Gavardi, L; Gavrilov, G; Gersabeck, E; Gersabeck, M; Gershon, T; Ghez, Ph; Gianelle, A; Giani', S; Gibson, V; Giubega, L; Gligorov, V V; Göbel, C; Golubkov, D; Golutvin, A; Gomes, A; Gordon, H; Gotti, C; Grabalosa Gándara, M; Graciani Diaz, R; Granado Cardoso, L A; Graugés, E; Graziani, G; Grecu, A; Greening, E; Gregson, S; Griffith, P; Grillo, L; Grünberg, O; Gui, B; Gushchin, E; Guz, Yu; Gys, T; Hadjivasiliou, C; Haefeli, G; Haen, C; Haines, S C; Hall, S; Hamilton, B; Hampson, T; Han, X; Hansmann-Menzemer, S; Harnew, N; Harnew, S T; Harrison, J; He, J; Head, T; Heijne, V; Hennessy, K; Henrard, P; Henry, L; Hernando Morata, J A; van Herwijnen, E; Heß, M; Hicheur, A; Hill, D; Hoballah, M; Hombach, C; Hulsbergen, W; Hunt, P; Hussain, N; Hutchcroft, D; Hynds, D; Idzik, M; Ilten, P; Jacobsson, R; Jaeger, A; Jalocha, J; Jans, E; Jaton, P; Jawahery, A; Jing, F; John, M; Johnson, D; Jones, C R; Joram, C; Jost, B; Jurik, N; Kaballo, M; Kandybei, S; Kanso, W; Karacson, M; Karbach, T M; Karodia, S; Kelsey, M; Kenyon, I R; Ketel, T; Khanji, B; Khurewathanakul, C; Klaver, S; Klimaszewski, K; Kochebina, O; Kolpin, M; Komarov, I; Koopman, R F; Koppenburg, P; Korolev, M; Kozlinskiy, A; Kravchuk, L; Kreplin, K; Kreps, M; Krocker, G; Krokovny, P; Kruse, F; Kucewicz, W; Kucharczyk, M; Kudryavtsev, V; Kurek, K; Kvaratskheliya, T; La Thi, V N; Lacarrere, D; Lafferty, G; Lai, A; Lambert, D; Lambert, R W; Lanciotti, E; Lanfranchi, G; Langenbruch, C; Langhans, B; Latham, T; Lazzeroni, C; Le Gac, R; van Leerdam, J; Lees, J-P; Lefèvre, R; Leflat, A; Lefrançois, J; Leo, S; Leroy, O; Lesiak, T; Leverington, B; Li, Y; Liles, M; Lindner, R; Linn, C; Lionetto, F; Liu, B; Liu, G; Lohn, S; Longstaff, I; Lopes, J H; Lopez-March, N; Lowdon, P; Lu, H; Lucchesi, D; Luo, H; Lupato, A; Luppi, E; Lupton, O; Machefert, F; Machikhiliyan, I V; Maciuc, F; Maev, O; Malde, S; Manca, G; Mancinelli, G; Maratas, J; Marchand, J F; Marconi, U; Marin Benito, C; Marino, P; Märki, R; Marks, J; Martellotti, G; Martens, A; Martín Sánchez, A; Martinelli, M; Martinez Santos, D; Martinez Vidal, F; Martins Tostes, D; Massafferri, A; Matev, R; Mathe, Z; Matteuzzi, C; Mazurov, A; McCann, M; McCarthy, J; McNab, A; McNulty, R; McSkelly, B; Meadows, B; Meier, F; Meissner, M; Merk, M; Milanes, D A; Minard, M-N; Moggi, N; Molina Rodriguez, J; Monteil, S; Morandin, M; Morawski, P; Mordà, A; Morello, M J; Moron, J; Morris, A-B; Mountain, R; Muheim, F; Müller, K; Muresan, R; Mussini, M; Muster, B; Naik, P; Nakada, T; Nandakumar, R; Nasteva, I; Needham, M; Neri, N; Neubert, S; Neufeld, N; Neuner, M; Nguyen, A D; Nguyen, T D; Nguyen-Mau, C; Nicol, M; Niess, V; Niet, R; Nikitin, N; Nikodem, T; Novoselov, A; O'Hanlon, D P; Oblakowska-Mucha, A; Obraztsov, V; Oggero, S; Ogilvy, S; Okhrimenko, O; Oldeman, R; Onderwater, G; Orlandea, M; Otalora Goicochea, J M; Owen, P; Oyanguren, A; Pal, B K; Palano, A; Palombo, F; Palutan, M; Panman, J; Papanestis, A; Pappagallo, M; Parkes, C; Parkinson, C J; Passaleva, G; Patel, G D; Patel, M; Patrignani, C; Pazos Alvarez, A; Pearce, A; Pellegrino, A; Pepe Altarelli, M; Perazzini, S; Perez Trigo, E; Perret, P; Perrin-Terrin, M; Pescatore, L; Pesen, E; Petridis, K; Petrolini, A; Picatoste Olloqui, E; Pietrzyk, B; Pilař, T; Pinci, D; Pistone, A; Playfer, S; Plo Casasus, M; Polci, F; Poluektov, A; Polycarpo, E; Popov, A; Popov, D; Popovici, B; Potterat, C; Price, E; Prisciandaro, J; Pritchard, A; Prouve, C; Pugatch, V; Puig Navarro, A; Punzi, G; Qian, W; Rachwal, B; Rademacker, J H; Rakotomiaramanana, B; Rama, M; Rangel, M S; Raniuk, I; Rauschmayr, N; Raven, G; Reichert, S; Reid, M M; Dos Reis, A C; Ricciardi, S; Richards, S; Rihl, M; Rinnert, K; Rives Molina, V; Roa Romero, D A; Robbe, P; Rodrigues, A B; Rodrigues, E; Rodriguez Perez, P; Roiser, S; Romanovsky, V; Romero Vidal, A; Rotondo, M; Rouvinet, J; Ruf, T; Ruffini, F; Ruiz, H; Ruiz Valls, P; Sabatino, G; Saborido Silva, J J; Sagidova, N; Sail, P; Saitta, B; Salustino Guimaraes, V; Sanchez Mayordomo, C; Sanmartin Sedes, B; Santacesaria, R; Santamarina Rios, C; Santovetti, E; Sapunov, M; Sarti, A; Satriano, C; Satta, A; Saunders, D M; Savrie, M; Savrina, D; Schiller, M; Schindler, H; Schlupp, M; Schmelling, M; Schmidt, B; Schneider, O; Schopper, A; Schune, M-H; Schwemmer, R; Sciascia, B; Sciubba, A; Seco, M; Semennikov, A; Sepp, I; Serra, N; Serrano, J; Sestini, L; Seyfert, P; Shapkin, M; Shapoval, I; Shcheglov, Y; Shears, T; Shekhtman, L; Shevchenko, V; Shires, A; Silva Coutinho, R; Simi, G; Sirendi, M; Skidmore, N; Skwarnicki, T; Smith, N A; Smith, E; Smith, E; Smith, J; Smith, M; Snoek, H; Sokoloff, M D; Soler, F J P; Soomro, F; Souza, D; Souza De Paula, B; Spaan, B; Sparkes, A; Spradlin, P; Stagni, F; Stahl, M; Stahl, S; Steinkamp, O; Stenyakin, O; Stevenson, S; Stoica, S; Stone, S; Storaci, B; Stracka, S; Straticiuc, M; Straumann, U; Stroili, R; Subbiah, V K; Sun, L; Sutcliffe, W; Swientek, K; Swientek, S; Syropoulos, V; Szczekowski, M; Szczypka, P; Szilard, D; Szumlak, T; T'Jampens, S; Teklishyn, M; Tellarini, G; Teubert, F; Thomas, C; Thomas, E; van Tilburg, J; Tisserand, V; Tobin, M; Tolk, S; Tomassetti, L; Topp-Joergensen, S; Torr, N; Tournefier, E; Tourneur, S; Tran, M T; Tresch, M; Tsaregorodtsev, A; Tsopelas, P; Tuning, N; Ubeda Garcia, M; Ukleja, A; Ustyuzhanin, A; Uwer, U; Vagnoni, V; Valenti, G; Vallier, A; Vazquez Gomez, R; Vazquez Regueiro, P; Vázquez Sierra, C; Vecchi, S; Velthuis, J J; Veltri, M; Veneziano, G; Vesterinen, M; Viaud, B; Vieira, D; Vieites Diaz, M; Vilasis-Cardona, X; Vollhardt, A; Volyanskyy, D; Voong, D; Vorobyev, A; Vorobyev, V; Voß, C; Voss, H; de Vries, J A; Waldi, R; Wallace, C; Wallace, R; Walsh, J; Wandernoth, S; Wang, J; Ward, D R; Watson, N K; Websdale, D; Whitehead, M; Wicht, J; Wiedner, D; Wilkinson, G; Williams, M P; Williams, M; Wilson, F F; Wimberley, J; Wishahi, J; Wislicki, W; Witek, M; Wormser, G; Wotton, S A; Wright, S; Wu, S; Wyllie, K; Xie, Y; Xing, Z; Xu, Z; Yang, Z; Yuan, X; Yushchenko, O; Zangoli, M; Zavertyaev, M; Zhang, L; Zhang, W C; Zhang, Y; Zhelezov, A; Zhokhov, A; Zhong, L; Zvyagin, A

    2014-08-22

    The difference in the angular distributions between beauty quarks and antiquarks, referred to as the charge asymmetry, is measured for the first time in bb pair production at a hadron collider. The data used correspond to an integrated luminosity of 1.0 fb(-1) collected at 7 TeV center-of-mass energy in proton-proton collisions with the LHCb detector. The measurement is performed in three regions of the invariant mass of the bb system. The results obtained are A(C)(bb))(40 105 GeV/c(2)) = 1.6 ± 1.7 ± 0.6%, where A(C)(bb)) is defined as the asymmetry in the difference in rapidity between jets formed from the beauty quark and antiquark, where in each case the first uncertainty is statistical and the second systematic. The beauty jets are required to satisfy 2 < η < 4, E(T) >20 GeV, and have an opening angle in the transverse plane Δ ϕ > 2.6 rad. These measurements are consistent with the predictions of the standard model. PMID:25192090

  17. Beauty salon health intervention increases fruit and vegetable consumption in African-American women.

    PubMed

    Johnson, Latasha T; Ralston, Penny A; Jones, Ethel

    2010-06-01

    African Americans, especially women, have low fruit and vegetable consumption, which is related to higher rates of obesity, morbidity, and mortality in comparison to whites. Community-based approaches are recommended to address this problem, including beauty salons, which are conducive environments for health information dissemination. The purpose of this pilot study, conducted in 2007, was to determine the effectiveness of a 6-week beauty salon-based health intervention, Steps for a New You, in improving diet, physical activity, and water consumption behaviors in African-American women using a quasiexperimental design. A random sample of 20 African-American women was selected from a list of regular clients at two beauty salons (n=10 each for treatment and comparison salons) located in a Southern rural community. The intervention included scripted motivational sessions between the cosmetologist and clients, information packets, and a starter kit of sample items. Data were collected using pre- and posttest questionnaires. The results showed that mean intake of fruit and vegetables was significantly higher at posttest for the treatment group but not for the comparison group. These findings suggest that the intervention may have had a positive effect on fruit and vegetable consumption by treatment group participants. However, further work is needed to refine the methodology, especially strengthening the intervention to increase physical activity and water consumption. PMID:20497787

  18. Open beauty measurements in pPb collisions with CMS

    NASA Astrophysics Data System (ADS)

    Kim, Hyunchul

    2014-11-01

    The B+, B0 and Bs0 mesons are exclusively reconstructed in proton-lead (pPb) collisions at √{sNN} = 5.02 TeV by the CMS Collaboration at the Large Hadron Collider (LHC). The cross sections are measured in the range of transverse momentum of 10 to 60 GeV / c and the center-of-mass rapidity smaller than 1.93. The nuclear modification factor, which is the ratio of the cross section in between pPb and proton-proton (pp) collisions, is estimated using the experimental data from pPb collisions and theoretical calculations as the pp reference. The calculated nuclear modification factors for each particle species are consistent with unity within the current uncertainties. The forward-to-backward asymmetry of B+ is also analyzed and does not show any nuclear effect in the measured rapidity range.

  19. Alpha Particle

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    Term that is sometimes used to describe a helium nucleus, a positively charged particle that consists of two protons and two neutrons, bound together. Alpha particles, which were discovered by Ernest Rutherford (1871-1937) in 1898, are emitted by atomic nuclei that are undergoing alpha radioactivity. During this process, an unstable heavy nucleus spontaneously emits an alpha particle and transmut...

  20. Particle generator

    DOEpatents

    Hess, Wayne P.; Joly, Alan G.; Gerrity, Daniel P.; Beck, Kenneth M.; Sushko, Peter V.; Shlyuger, Alexander L.

    2005-06-28

    Energy tunable solid state sources of neutral particles are described. In a disclosed embodiment, a halogen particle source includes a solid halide sample, a photon source positioned to deliver photons to a surface of the halide, and a collimating means positioned to accept a spatially defined plume of hyperthermal halogen particles emitted from the sample surface.

  1. Particle Detectors

    NASA Astrophysics Data System (ADS)

    Grupen, Claus; Shwartz, Boris

    2011-09-01

    Preface to the first edition; Preface to the second edition; Introduction; 1. Interactions of particles and radiation with matter; 2. Characteristic properties of detectors; 3. Units of radiation measurements and radiation sources; 4. Accelerators; 5. Main physical phenomena used for particle detection and basic counter types; 6. Historical track detectors; 7. Track detectors; 8. Calorimetry; 9. Particle identification; 10. Neutrino detectors; 11. Momentum measurement and muon detection; 12. Ageing and radiation effects; 13. Example of a general-purpose detector: Belle; 14. Electronics; 15. Data analysis; 16. Applications of particle detectors outside particle physics; 17. Glossary; 18. Solutions; 19. Resumé; Appendixes; Index.

  2. Transcranial Direct Current Stimulation over the Medial Prefrontal Cortex and Left Primary Motor Cortex (mPFC-lPMC) Affects Subjective Beauty but Not Ugliness.

    PubMed

    Nakamura, Koyo; Kawabata, Hideaki

    2015-01-01

    Neuroaesthetics has been searching for the neural bases of the subjective experience of beauty. It has been demonstrated that neural activities in the medial prefrontal cortex (mPFC) and the left primary motor cortex (lPMC) correlate with the subjective experience of beauty. Although beauty and ugliness seem to be semantically and conceptually opposite, it is still unknown whether these two evaluations represent extreme opposites in unitary or bivariate dimensions. In this study, we applied transcranial direct current stimulation (tDCS) to examine whether non-invasive brain stimulation modulates two types of esthetic evaluation; evaluating beauty and ugliness. Participants rated the subjective beauty and ugliness of abstract paintings before and after the application of tDCS. Application of cathodal tDCS over the mPFC with anode electrode over the lPMC, which induced temporal inhibition of neural excitability of the mPFC, led to a decrease in beauty ratings but not ugliness ratings. There were no changes in ratings of both beauty and ugliness when applying anodal tDCS or sham stimulation over the mPFC. Results from our experiment indicate that the mPFC and the lPMC have a causal role in generating the subjective experience of beauty, with beauty and ugliness evaluations constituting two distinct dimensions. PMID:26696865

  3. Transcranial Direct Current Stimulation over the Medial Prefrontal Cortex and Left Primary Motor Cortex (mPFC-lPMC) Affects Subjective Beauty but Not Ugliness

    PubMed Central

    Nakamura, Koyo; Kawabata, Hideaki

    2015-01-01

    Neuroaesthetics has been searching for the neural bases of the subjective experience of beauty. It has been demonstrated that neural activities in the medial prefrontal cortex (mPFC) and the left primary motor cortex (lPMC) correlate with the subjective experience of beauty. Although beauty and ugliness seem to be semantically and conceptually opposite, it is still unknown whether these two evaluations represent extreme opposites in unitary or bivariate dimensions. In this study, we applied transcranial direct current stimulation (tDCS) to examine whether non-invasive brain stimulation modulates two types of esthetic evaluation; evaluating beauty and ugliness. Participants rated the subjective beauty and ugliness of abstract paintings before and after the application of tDCS. Application of cathodal tDCS over the mPFC with anode electrode over the lPMC, which induced temporal inhibition of neural excitability of the mPFC, led to a decrease in beauty ratings but not ugliness ratings. There were no changes in ratings of both beauty and ugliness when applying anodal tDCS or sham stimulation over the mPFC. Results from our experiment indicate that the mPFC and the lPMC have a causal role in generating the subjective experience of beauty, with beauty and ugliness evaluations constituting two distinct dimensions. PMID:26696865

  4. Beauty is Attractive: Moduli Trapping at Enhanced Symmetry Points

    SciTech Connect

    Kofman, L

    2004-02-27

    We study quantum effects on moduli dynamics arising from the production of particles which are light at points of enhanced symmetry in moduli space. The resulting forces trap the moduli at these points. Moduli trapping occurs in time-dependent quantum field theory, as well as in systems of moving D-branes, where it leads the branes to combine into stacks. Trapping also occurs in the presence of gravity, though the range over which the moduli can roll is limited by Hubble friction. We observe that a scalar field trapped on a steep potential can induce a stage of acceleration of the universe, which we call trapped inflation. Moduli trapping ameliorates the cosmological moduli problem and may affect vacuum selection. In particular, rolling moduli are most powerfully attracted to the points of greatest symmetry. Given suitable assumptions about the dynamics of the very early universe, this effect might help to explain why among the plethora of possible vacuum states of string theory, we appear to live in one with a large number of (spontaneously broken) symmetries.

  5. The Intrinsic Beauty of Polytropic Spheres in Reduced Variables

    NASA Astrophysics Data System (ADS)

    Caimmi, Roberto

    The concept of reduced variables is revisited with regard to van der Waals' theory and an application is made to polytropic spheres, where the reduced radial coordinate is ${\\rm red}(r)=r/R=\\xi/\\Xi$, $R$ radius, and the reduced density is ${\\rm red}(\\rho)=\\rho/\\lambda=\\theta^n$, $\\lambda$ central density. Reduced density profiles are plotted for several polytropic indexes within the range, $0\\le n\\le5$, disclosing two noticeable features. First, any point of coordinates, $({\\rm red}(r),{\\rm red}(\\rho))$, $0\\le{\\rm red}(r)\\le1$, $0\\le{\\rm red}(\\rho)\\le1$, belongs to a reduced density profile of the kind considered. Second, sufficiently steep i.e. large $n$ reduced density profiles exhibit an oblique inflection point, where the threshold is found to be located at $n=n_{\\rm th}=0.888715$. Reduced pressure profiles, ${\\rm red}(P)=P/\\varpi=\\theta^{n+1}$, $\\varpi$ central pressure, Lane-Emden fucntions, $\\theta=(\\rho/\\lambda)^{1/n}$, and polytropic curves, ${\\rm red}(P)={\\rm red}(P)({\\rm red}(\\rho))$, are also plotted. The method can be extended to nonspherical polytropes with regard to a selected direction, ${\\rm red}(r)(\\mu)=r(\\mu)/R(\\mu)=\\xi(\\mu)/\\Xi(\\mu)$. The results can be extended to polytropic spheres made of collisionless particles, for polytropic index within a more restricted range, $1/2\\le n\\le5$.

  6. Particle astrophysics

    NASA Astrophysics Data System (ADS)

    Sadoulet, Bernard; Cronin, James; Aprile, Elena; Barish, Barry C.; Beier, Eugene W.; Brandenberger, Robert; Cabrera, Blas; Caldwell, David; Cassiday, George; Cline, David B.

    The following scientific areas are reviewed: (1) cosmology and particle physics (particle physics and the early universe, dark matter, and other relics); (2) stellar physics and particles (solar neutrinos, supernovae, and unconventional particle physics); (3) high energy gamma ray and neutrino astronomy; (4) cosmic rays (space and ground observations). Highest scientific priorities for the next decade include implementation of the current program, new initiatives, and longer-term programs. Essential technological developments, such as cryogenic detectors of particles, new solar neutrino techniques, and new extensive air shower detectors, are discussed. Also a certain number of institutional issues (the funding of particle astrophysics, recommended funding mechanisms, recommended facilities, international collaborations, and education and technology) which will become critical in the coming decade are presented.

  7. Particle therapy

    SciTech Connect

    Raju, M.R.

    1993-09-01

    Particle therapy has a long history. The experimentation with particles for their therapeutic application got started soon after they were produced in the laboratory. Physicists played a major role in proposing the potential applications in radiotherapy as well as in the development of particle therapy. A brief review of the current status of particle radiotherapy with some historical perspective is presented and specific contributions made by physicists will be pointed out wherever appropriate. The rationale of using particles in cancer treatment is to reduce the treatment volume to the target volume by using precise dose distributions in three dimensions by using particles such as protons and to improve the differential effects on tumors compared to normal tissues by using high-LET radiations such as neutrons. Pions and heavy ions combine the above two characteristics.

  8. Particle astrophysics

    NASA Technical Reports Server (NTRS)

    Sadoulet, Bernard; Cronin, James; Aprile, Elena; Barish, Barry C.; Beier, Eugene W.; Brandenberger, Robert; Cabrera, Blas; Caldwell, David; Cassiday, George; Cline, David B.

    1991-01-01

    The following scientific areas are reviewed: (1) cosmology and particle physics (particle physics and the early universe, dark matter, and other relics); (2) stellar physics and particles (solar neutrinos, supernovae, and unconventional particle physics); (3) high energy gamma ray and neutrino astronomy; (4) cosmic rays (space and ground observations). Highest scientific priorities for the next decade include implementation of the current program, new initiatives, and longer-term programs. Essential technological developments, such as cryogenic detectors of particles, new solar neutrino techniques, and new extensive air shower detectors, are discussed. Also a certain number of institutional issues (the funding of particle astrophysics, recommended funding mechanisms, recommended facilities, international collaborations, and education and technology) which will become critical in the coming decade are presented.

  9. Beauty product-related exposures and childhood brain tumors in seven countries: results from the SEARCH International Brain Tumor Study.

    PubMed

    Efird, J T; Holly, E A; Cordier, S; Mueller, B A; Lubin, F; Filippini, G; Peris-Bonet, R; McCredie, M; Arslan, A; Bracci, P; Preston-Martin, S

    2005-04-01

    Data from 1218 cases of childhood brain tumors (CBT) diagnosed between 1976 and 1994 and 2223 matched controls from the general population were included in an analysis of maternal beauty product exposure and beauty-related employment in 9 centers in 7 countries. A 50% increased odds ratio (OR) [95% confidence interval (CI) = 1.0-2.1] for CBT was observed among children of mothers who were exposed via personal use of and/or possible ambient contact with beauty products during the 5 years preceding the index child's birth compared with children of mothers never exposed to beauty products during this time period. Overall maternal personal use of hair-coloring agents in the month before or during the pregnancy of the index child's birth was not associated with CBT (OR = 1.0, CI = 0.83-1.3) or with astroglial (OR = 1.1, CI = 0.85-1.4), PNET (OR = 1.0, CI = 0.71-1.5) and other glial subtypes (OR = 1.0, CI = 0.62-1.0). Similarly, no statistically increased ORs or discernable pattern of risk estimates were observed for period of use or for number of applications per year for maternal personal use of hair-coloring agents overall or by histologic type. Among children born on or after 1980, increased ORs for CBT were associated with maternal non-work-related exposure to any beauty products (OR = 2.6, CI = 1.2-5.9), hair-dyes (OR = 11, CI = 1.2-90), and hair sprays (OR = 3.4, CI = 1.0-11). No overall increased OR for CBT was observed among children of mothers employed in beauty-related jobs during the 5 years preceding the index child's birth compared with those who reported no beauty-related employment. In general, other specific beauty product-related exposures were not associated with increased ORs for CBT. Data from our study provide little evidence of an increased risk for CBT with mothers' exposures to beauty products. PMID:15925993

  10. "That's not just beautiful--that's incredibly beautiful!": the adverse impact of inflated praise on children with low self-esteem.

    PubMed

    Brummelman, Eddie; Thomaes, Sander; Orobio de Castro, Bram; Overbeek, Geertjan; Bushman, Brad J

    2014-03-01

    In current Western society, children are often lavished with inflated praise (e.g., "You made an incredibly beautiful drawing!"). Inflated praise is often given in an attempt to raise children's self-esteem. An experiment (Study 1) and naturalistic study (Study 2) found that adults are especially inclined to give inflated praise to children with low self-esteem. This inclination may backfire, however. Inflated praise might convey to children that they should continue to meet very high standards-a message that might discourage children with low self-esteem from taking on challenges. Another experiment (Study 3) found that inflated praise decreases challenge seeking in children with low self-esteem and has the opposite effect on children with high self-esteem. These findings show that inflated praise, although well intended, may cause children with low self-esteem to avoid crucial learning experiences. PMID:24434235

  11. ‘For me… it’s a miracle’: injecting beauty among kathoeis in a provincial Thai city

    PubMed Central

    Poompruek, Panoopat; Boonmongkon, Pimpawun; Guadamuz, Thomas E.

    2014-01-01

    Background The Thai term kathoei refers to non-gender-normative females, males and intersexual individuals at different stages of the transitional spectrum with recognized social and cultural roles in society. Nevertheless, kathoeis are only tolerated in Thai society. Many kathoeis seek social acceptance through beauty and turn to the off-label injection of various ‘beauty drugs’. Methods The first author conducted an ethnographic study of injection parties at a wedding studio in a Central Thai provincial city between April and September 2011. Data were gathered through participant observation, focus group discussions and narrative interviews with six participants. All data were collected and analyzed in Thai, and later translated. Findings While injection parties provide opportunities for kathoeis to socialize, bond, and share experiential knowledge on chemically-assisted transformation, they also reproduce ideologies of gender, beauty and sexuality that reinforce the notion that if a kathoei is to maintain her beauty, she must use medicines more frequently and in higher doses. Conclusion Injection parties among Thai kathoeis feature drug use that is entirely reasonable in terms of their own lay knowledge. Empowering kathoeis, by providing accessible information on chemicals and health in a way that reflects the complexity and diversity of their practices, would be one way to reduce health risks. Society must give more long-term options to kathoeis to build their sense of self, based on things besides being beautiful. PMID:25047007

  12. What flowers do we like? The influence of shape and color on the rating of flower beauty.

    PubMed

    Hůla, Martin; Flegr, Jaroslav

    2016-01-01

    There is no doubt that people find flowers beautiful. Surprisingly, we know very little about the actual properties which make flowers so appealing to humans. Although the evolutionary aesthetics provides some theories concerning generally preferred flower traits, empirical evidence is largely missing. In this study, we used an online survey in which residents of the Czech Republic (n = 2006) rated the perceived beauty of 52 flower stimuli of diverse shapes and colors. Colored flowers were preferred over their uncolored versions. When controlling for flower shape, we found an unequal preference for different flower colors, blue being the most and yellow the least preferred. In the overall assessment of beauty, shape was more important than color. Prototypical flowers, i.e., radially symmetrical flowers with low complexity, were rated as the most beautiful. We also found a positive effect of sharp flower contours and blue color on the overall rating of flower beauty. The results may serve as a basis for further studies in some areas of the people-plant interaction research. PMID:27330863

  13. What flowers do we like? The influence of shape and color on the rating of flower beauty

    PubMed Central

    Flegr, Jaroslav

    2016-01-01

    There is no doubt that people find flowers beautiful. Surprisingly, we know very little about the actual properties which make flowers so appealing to humans. Although the evolutionary aesthetics provides some theories concerning generally preferred flower traits, empirical evidence is largely missing. In this study, we used an online survey in which residents of the Czech Republic (n = 2006) rated the perceived beauty of 52 flower stimuli of diverse shapes and colors. Colored flowers were preferred over their uncolored versions. When controlling for flower shape, we found an unequal preference for different flower colors, blue being the most and yellow the least preferred. In the overall assessment of beauty, shape was more important than color. Prototypical flowers, i.e., radially symmetrical flowers with low complexity, were rated as the most beautiful. We also found a positive effect of sharp flower contours and blue color on the overall rating of flower beauty. The results may serve as a basis for further studies in some areas of the people-plant interaction research. PMID:27330863

  14. Magnetic particles

    NASA Technical Reports Server (NTRS)

    Chang, Manchium (Inventor); Colvin, Michael S. (Inventor)

    1989-01-01

    Magnetic polymer particles are formed by swelling porous, polymer particles and impregnating the particles with an aqueous solution of precursor magnetic metal salt such as an equimolar mixture of ferrous chloride and ferric chloride. On addition of a basic reagent such as dilute sodium hydroxide, the metal salts are converted to crystals of magnetite which are uniformly contained througout the pores of the polymer particle. The magnetite content can be increased and neutral buoyancy achieved by repetition of the impregnaton and neutralization steps to adjust the magnetite content to a desired level.

  15. A Study of the Possible Harmful Effects of Cosmetic Beauty Products on Human Health.

    PubMed

    Kaličanin, Biljana; Velimirović, Dragan

    2016-04-01

    The origins of the usage of different substances in beauty, skin, body, hair, and nails care products can be found in ancient times. To achieve better quality and enhance their effects, some additives such as preservatives, stabilizers, mineral pigments, dye, and shine were added to these products. Some of these substances may also have allergic, irritating, and harmful effects on human health. The aim of this study was the optimization of the potentiometric stripping analysis (PSA) for the purpose of determining the content of heavy metals (lead, cadmium, zinc), in some commercial cosmetic beauty products (lipsticks, lip glosses, eye shadows, and henna hair dye). In addition, in order to monitor the potential adverse effects of henna dye on hair quality, as well as the total body burden of heavy metals (Pb, Cd), the paper analyzed hair samples before and after henna dye treatment. Beauty products used for cosmetic purposes can have adverse effects to human health due to the fact that they contain lead, a highly toxic metal. The lead content in the tested samples varied depending on the additives used along with the method of production. The cosmetic products that were analyzed in this study contained a certain amount of zinc, which is an essential element, although its content above the prescribed limit may lead to side effects. Highly toxic metal, cadmium, was not detected in the tested samples. The presence of these metals in cosmetic products certainly indicate that it is necessary to monitor and determinate the content of toxic heavy metals in these products, especially because they are in direct contact with skin or mucous membranes and are often used in daily life. PMID:26296330

  16. Cosmetic medical treatments: why are we so obsessed with beauty-is it nature or nurture?

    PubMed

    Jonzon, Kirsten

    2009-01-01

    Cosmetic medical treatments have become mainstream, and images of beauty surround us on television, in magazines, and in advertising. It is no wonder that the quest for beauty has become so prevalent. This paper explores why individuals choose to undergo cosmetic procedures, and looks at the nature versus nurture debate surrounding this phenomenon. It is important for nurses, physicians, nurse practitioners, or other healthcare professionals involved in the cosmetic surgery field to understand the underlying motivations for choosing to undergo elective cosmetic procedures in order to make appropriate choices about their patients' care. The first theory in this article is rooted in the "nature" school-of-thought and explores the evolutionary basis behind the quest for beauty. It shows that we may be 'hardwired' to think that our appearance signals our reproductive capability (D. B. Sarwer, L. Magee, & V. Clark, 2004) and that human physical attractiveness is merely a collection of physical traits that signal fecundity and health (V. Swami, C. Greven, & A. Furnham, 2007). The "nurture" concept focuses on the second theory, the sociocultural theory, which implies that people who choose to use cosmetic medical treatments to enhance their appearance may be attempting to increase their self-image or self-perception, improve their social relationships, and increase their probability of success across a variety of social situations. Other minor theories such as the estrogen theory and the psychological theory are discussed, along with implications for practice. All of these theories are valuable to the healthcare professional and allow a deeper understanding of the psyche of their patients. PMID:20029301

  17. A novel method for somatic transgenesis of the mouse prostate using the Sleeping Beauty transposon system

    PubMed Central

    Hammer, Kimberly D.P.; Alsop, Jim; Buresh-Stiemke, Rita A.; Frantskevich, Katsiaryna; Malinowski, Rita; Roethe, Laura; Powers, Ginny L; Marker, Paul C.

    2014-01-01

    BACKGROUND In vivo ectopic gene expression is a common approach for prostate research through the use of transgenes in germline transgenic mice. For some other organs, somatic transgenesis with the Sleeping Beauty transposon system has allowed in vivo ectopic gene expression with higher throughput and lower cost than germline transgenic approaches. METHODS Mouse e16 urogenital sinuses (UGSs) were co-injected with plasmids expressing the Sleeping Beauty transposase and plasmids with control or activated BRAF expressing transposons. Following electroporation, the transduced UGSs were grown as allografts in mouse hosts for 8 weeks, and the resulting allografts were evaluated for several endpoints. RESULTS Transposon-transduced UGS allografts developed into prostatic tissue with normal tissue structure and cellular differentiation. Integration of transposon vectors into the genomes of transduced allografts was confirmed using linker-mediated PCR, sequencing, and in situ PCR. Transduction of UGS allografts with transposons expressing activated BRAF resulted in ectopic BRAF expression that was detectable at both the mRNA and protein levels. Prostatic ducts over-expressing activated BRAF also had ectopic activation of the ERK1/2 mitogen activated kinases and increased epithelial cell proliferation. CONCLUSIONS The Sleeping Beauty transposon system can be used to achieve somatic transgenesis of prostatic allografts. This new method for achieving ectopic gene expression in the prostate will complement other existing approaches such as ectopic gene expression in cell lines and in germline transgenic mice. Advantages of this new approach include preservation of stromal-epithelial interactions not possible with cell lines, and higher throughput and lower cost than traditional germline transgenic approaches. PMID:24647932

  18. Quality of life assessment in cosmetics: specificity and interest of the international BeautyQol instrument.

    PubMed

    Beresniak, Ariel; Auray, Jean-Paul; Duru, Gérard; Aractingi, Selim; Krueger, Gerald G; Talarico, Sergio; Tsutani, Kiichiro; Dupont, Danielle; de Linares, Yolaine

    2015-09-01

    The wide use of cosmetics and their perceived benefits upon well-being imply objective descriptions of their effects upon the different dimensions contributing to the quality of life (QoL). Such a goal pleas for using relevant and validated scientific instruments with robust measurement methods. This paper discusses the interest of the new validated questionnaire BeautyQoL specifically designed to assess the effect of cosmetic products on physical appearance and QoL. After conducting a review of skin appearance and QoL, three phases of the international codevelopment have been carried out in the following sequence: semi-directed interviews (Phase 1), acceptability study (Phase 2), and validation study (Phase 3). Data collection and validation process have been carried out in 16 languages. This review confirms that QoL instruments developed in dermatology are not suitable to assess cosmetic products, mainly because of their lack of sensitivity. General acceptability of BeautyQol was very good. Forty-two questions have been structured in five dimensions that explained 76.7% of the total variance: Social Life, Self-confidence, Mood, Vitality, and Attractiveness. Cronbach's alpha coefficients are between 0.932 and 0.978, confirming the good internal consistency of the results. The BeautyQol questionnaire is the first international instrument specific to cosmetic products and physical appearance that has been validated in 16 languages and could be used in a number of clinical trials and descriptive studies to demonstrate the added value of these products on the QoL. PMID:26133392

  19. Particle preconcentrator

    DOEpatents

    Linker, K.L.; Conrad, F.J.; Custer, C.A.; Rhykerd, C.L. Jr.

    1998-12-29

    An apparatus and method are disclosed for preconcentrating particles and vapors. The preconcentrator apparatus permits detection of highly diluted amounts of particles in a main gas stream, such as a stream of ambient air. A main gas stream having airborne particles entrained therein is passed through a pervious screen. The particles accumulate upon the screen, as the screen acts as a sort of selective particle filter. The flow of the main gas stream is then interrupted by diaphragm shutter valves, whereupon a cross-flow of carrier gas stream is blown parallel past the faces of the screen to dislodge the accumulated particles and carry them to a particle or vapor detector, such as an ion mobility spectrometer. The screen may be heated, such as by passing an electrical current there through, to promote desorption of particles therefrom during the flow of the carrier gas. Various types of screens are disclosed. The apparatus and method of the invention may find particular utility in the fields of narcotics, explosives detection and chemical agents. 3 figs.

  20. Particle preconcentrator

    SciTech Connect

    Linker, K.L.; Conrad, F.J.; Custer, C.A.; Rhykerd, C.L. Jr

    2000-07-11

    An apparatus and method are disclosed for preconcentrating particles and vapors. The preconcentrator apparatus permits detection of highly diluted amounts of particles in a main gas stream, such as a stream of ambient air. A main gas stream having airborne particles entrained therein is passed through a previous screen. The particles accumulate upon the screen, as the screen acts as a sort of selective particle filter. The flow of the main gas stream is then interrupted by diaphragm shutter valves, whereupon a cross-flow of carrier gas stream is blown parallel past the faces of the screen to dislodge the accumulated particles and carry them to a particle or vapor detector, such as an ion mobility spectrometer. The screen may be heated, such as by passing an electrical current there through, to promote desorption of particles therefrom during the flow of the carrier gas. Various types of screens are disclosed. The apparatus and method of the invention may find particular utility in the fields of narcotics, explosives detection and chemical agents.

  1. Particle preconcentrator

    SciTech Connect

    Linker, Kevin L.; Conrad, Frank J.; Custer, Chad A.; Rhykerd, Jr., Charles L.

    1998-01-01

    An apparatus and method for preconcentrating particles and vapors. The preconcentrator apparatus permits detection of highly diluted amounts of particles in a main gas stream, such as a stream of ambient air. A main gas stream having airborne particles entrained therein is passed through a pervious screen. The particles accumulate upon the screen, as the screen acts as a sort of selective particle filter. The flow of the main gas stream is then interrupted by diaphragm shutter valves, whereupon a cross-flow of carrier gas stream is blown parallel past the faces of the screen to dislodge the accumulated particles and carry them to a particle or vapor detector, such as an ion mobility spectrometer. The screen may be heated, such as by passing an electrical current there through, to promote desorption of particles therefrom during the flow of the carrier gas. Various types of screens are disclosed. The apparatus and method of the invention may find particular utility in the fields of narcotics, explosives detection and chemical agents.

  2. Particle preconcentrator

    SciTech Connect

    Linker, Kevin L.; Conrad, Frank J.; Custer, Chad A.; Rhykerd, Jr., Charles L.

    2005-09-20

    An apparatus and method for preconcentrating particles and vapors. The preconcentrator apparatus permits detection of highly diluted amounts of particles in a main gas stream, such as a stream of ambient air. A main gas stream having airborne particles entrained therein is passed through a pervious screen. The particles accumulate upon the screen, as the screen acts as a sort of selective particle filter. The flow of the main gas stream is then interrupted by diaphragm shutter valves, whereupon a cross-flow of carrier gas stream is blown parallel past the faces of the screen to dislodge the accumulated particles and carry them to a particle or vapor detector, such as an ion mobility spectrometer. The screen may be heated, such as by passing an electrical current there through, to promote desorption of particles therefrom during the flow of the carrier gas. Various types of screens are disclosed. The apparatus and method of the invention may find particular utility in the fields of narcotics, explosives detection and chemical agents.

  3. Particle preconcentrator

    SciTech Connect

    Linker, Kevin L.; Conrad, Frank J.; Custer, Chad A.; Rhykerd, Jr., Charles L.

    2000-01-01

    An apparatus and method for preconcentrating particles and vapors. The preconcentrator apparatus permits detection of highly diluted amounts of particles in a main gas stream, such as a stream of ambient air. A main gas stream having airborne particles entrained therein is passed through a pervious screen. The particles accumulate upon the screen, as the screen acts as a sort of selective particle filter. The flow of the main gas stream is then interrupted by diaphragm shutter valves, whereupon a cross-flow of carrier gas stream is blown parallel past the faces of the screen to dislodge the accumulated particles and carry them to a particle or vapor detector, such as an ion mobility spectrometer. The screen may be heated, such as by passing an electrical current there through, to promote desorption of particles therefrom during the flow of the carrier gas. Various types of screens are disclosed. The apparatus and method of the invention may find particular utility in the fields of narcotics, explosives detection and chemical agents.

  4. Experience of gratitude, awe and beauty in life among patients with multiple sclerosis and psychiatric disorders

    PubMed Central

    2014-01-01

    Background Feelings of gratitude and awe facilitate perceptions and cognitions that go beyond the focus of illness and include positive aspects of one’s personal and interpersonal reality, even in the face of disease. We intended to measure feelings of gratitude, awe, and experiences of beauty in life among patients with multiple sclerosis and psychiatric disorders, particularly with respect to their engagement in specific spiritual/religious practices and their life satisfaction. Methods We conducted a cross-sectional survey with standardized questionnaires to measure engagement in various spiritual practices (SpREUK-P) and their relation to experiences of Gratitude, Awe and Beauty in Life and life satisfaction (BMLSS-10). In total, 461 individuals (41 ± 13 years; 68% women) with multiple sclerosis (46%) and depressive (22%) or other psychiatric disorders (32%) participated. Results Among participants, 23% never, 43% rarely, 24% often, and 10% frequently experienced Gratitude. In contrast, 41% never, 37% rarely, 17% often, and 6% frequently experienced Awe. Beauty in Life was never experienced by 8% of the sample, and 28% rarely, 46% often, and 18% frequently experienced it. Gratitude (F = 9.2; p = .003) and Beauty in Life (F = 6.0; p = .015) were experienced significantly more often by women than men. However, the experience of Awe did not differ between women and men (F = 2.2; n.s.). In contrast to our hypothesis, Gratitude/Awe cannot explain any relevant variance in patients’ life satisfaction (R2 = .04). Regression analyses (R2 = .42) revealed that Gratitude/Awe can be predicted best by a person’s engagement in religious practices, followed by other forms of spiritual practices and life satisfaction. Female gender was a weak predictor and underlying disease showed no effect. Conclusions Gratitude/Awe could be regarded as a life orientation towards noticing and appreciating the positive in life - despite the symptoms of

  5. Beauty Matters: Social Preferences in a Three-Person Ultimatum Game

    PubMed Central

    2015-01-01

    Preference for beauty is human nature, as previous behavior studies have supported the notion of “beauty premium” in which attractive people were more easily to get promoted and receive higher salaries. In the present study, 29 males were recruited to participate in a three-person ultimatum game (UG) including a proposer, a responder and a powerless third player. Each subject, playing as the responder, had to decide whether to accept an offer from the allocator both for himself and a female third person. We aimed to elucidate how the facial attractiveness of the female subject affected the male subjects’ fairness and decision-making in social exchanges. Frontal feedback-related negativity (FRN) in response to four offers in an attractive-face condition revealed no significant differences between offers; however, when the companion was an unattractive female, an “unfair/fair” offer, which assigned a lower share to the responder and a fair share to the third player, elicited the largest FRN. Furthermore, when the third player was offered the smallest amount (“fair/unfair” offer), a larger FRN was generated in an attractive-face condition than unattractive-face condition. In the “unfair/fair” offer condition in which subjects received a smaller allocation than the third person, the beauty of their female counterparts attenuated subjects’ aversion to inequality, resulting in a less negative FRN in the frontal region and an increased acceptance ratio. However, the influence of the third player’s facial attractiveness only affected the early evaluation stage: late P300 was found to be immune to the “beauty premium”. Under the two face conditions, P300 was smallest following an “unfair/fair” offer, whereas the amplitudes in the other three offer conditions exhibited no significant differences. In addition, the differentiated neural features of processing facial attractiveness were also determined and indexed by four event-related potentials

  6. Non multa, sed multum: Future lessons from two-prong, two-body decays of beauty

    SciTech Connect

    Bigi, I.I.; Stech, B.

    1987-12-01

    There are four two-body, two-prong decays modes of B mesons and two for beauty baryons and they are quite rare, i.e., their branching ratios are not expected to exceed the script O(10/sup -4/) level. Yet a detailed study of their relative rates with a sensitivity level of 10/sup -5/ can yield unique and important information on strong interactions. If the evolution of these reactions in proper time can be traced then, under favorable conditions, one can analyze B/sup 0/ - anti B/sup 0/ mixing and CP invariance in a detailed way. 4 refs.

  7. The beauty of anatomy: visual displays and surgical education in early-nineteenth-century London.

    PubMed

    Berkowitz, Carin

    2011-01-01

    The early-nineteenth-century artist, anatomist, and teacher Sir Charles Bell saw anatomy and art as closely related subjects. He taught anatomy to artists and surgeons, illustrated his own anatomical texts, and wrote a treatise on the use of anatomy in art. The author explores the connections among visual displays representing human anatomy, aesthetics, and pedagogical practices for Bell and a particular group of British surgeon-anatomists. Creating anatomical models and drawings was thought to discipline the surgeon's hand, while the study of anatomy and comparative anatomy would discipline the artist's eye. And for Bell, beauty made drawings into better pedagogical tools. PMID:21804185

  8. The GTTP Movement: Engaging young minds to the beauty of science and space exploration

    NASA Astrophysics Data System (ADS)

    Doran, Rosa

    2015-03-01

    The Galileo Teacher Training Program (GTTP) is a living legacy of IYA2009. As a cornerstone of this important moment in the history of Astronomy, GTTP has managed to name representatives in over 100 nations and reached over 15000 teachers at a global level. The model used so far ensures sustainability and a fast growing support network. The task at hand is to engage educators in the use of modern tools for science teaching. Building the classroom of tomorrow is a promising path to engage young minds to the beauty of science and space exploration.

  9. Hana-Densetsu Recognition of the Beauty of Life on Our Planet

    NASA Astrophysics Data System (ADS)

    Hasegawa, Yoichi; Tomita-Yokotani, Kaori; Yamashita, Masamichi

    HANA-densetsu is a new challenge of space utilization which creates unique values not only science but in culture and education fields. Cherry, Lily and Violet seeds, including natural treasures were carefully selected from many part of Japan. Those seeds had fulfilled eight months space journey on the ISS on behalf of children who picked them. It gave chance for many children to participate in a genuine space project by collecting flower seeds. Some parts of them are already germinated in their home town and growing vigorously. They are demonstrating the possibility of space agriculture as the ornamental plant which remind us "The Beauty of Life on Our Planet"

  10. What is beautiful is good and more accurately understood. Physical attractiveness and accuracy in first impressions of personality.

    PubMed

    Lorenzo, Genevieve L; Biesanz, Jeremy C; Human, Lauren J

    2010-12-01

    Beautiful people are seen more positively than others, but are they also seen more accurately? In a round-robin design in which previously unacquainted individuals met for 3 min, results were consistent with the "beautiful is good" stereotype: More physically attractive individuals were viewed with greater normative accuracy; that is, they were viewed more in line with the highly desirable normative profile. Notably, more physically attractive targets were viewed more in line with their unique self-reported personality traits, that is, with greater distinctive accuracy. Further analyses revealed that both positivity and accuracy were to some extent in the eye of the beholder: Perceivers' idiosyncratic impressions of a target's attractiveness were also positively related to the positivity and accuracy of impressions. Overall, people do judge a book by its cover, but a beautiful cover prompts a closer reading, leading more physically attractive people to be seen both more positively and more accurately. PMID:21051521

  11. Red, White and Black: Colors of Beauty, Tints of Health and Cosmetic Materials in Early Modern English Art Writing.

    PubMed

    Sammern, Romana

    2015-01-01

    Alongside Richard Haydocke's translation of Giovanni Paolo Lomazzo's treatise on painting (1598), the article examines concepts of color concerning cosmetics, painting and complexion as they relate to aesthetics, artistic and medical practice in the sixteenth and seventeenth centuries. Beginning with white and red as ideal colors of beauty in Agnolo Firenzuola's Discourse on the beauty of women (1541), the essay places color in relation to major issues in art, medicine and empiricism by discussing beauty as a quality of humoral theory and its colors as visual results of physiological processes. Challenging the relation of art and nature, gender and production, Lomazzo's account of complexion and Haydocke's additions on cosmetic practices and face-painting provide key passages that shed light on the relation of cosmetics colors, art writing and artistic practices at the convergence of the body, art and medicine in the context of the emerging English virtuosi around 1600. PMID:26856049

  12. Earth From Space: "Beautiful Earth's" Integration of Media Arts, Earth Science, and Native Wisdom in Informal Learning Environments

    NASA Astrophysics Data System (ADS)

    Casasanto, V.; Hallowell, R.; Williams, K.; Rock, J.; Markus, T.

    2015-12-01

    "Beautiful Earth: Experiencing and Learning Science in an Engaging Way" was a 3-year project funded by NASA's Competitive Opportunities in Education and Public Outreach for Earth and Space Science. An outgrowth of Kenji Williams' BELLA GAIA performance, Beautiful Earth fostered a new approach to teaching by combining live music, data visualizations and Earth science with indigenous perspectives, and hands-on workshops for K-12 students at 5 science centers. Inspired by the "Overview Effect," described by many astronauts who were awestruck by seeing the Earth from space and their realization of the profound interconnectedness of Earth's life systems, Beautiful Earth leveraged the power of multimedia performance to serve as a springboard to engage K-12 students in hands-on Earth science and Native wisdom workshops. Results will be presented regarding student perceptions of Earth science, environmental issues, and indigenous ways of knowing from 3 years of evaluation data.

  13. Constraining Particle Sizes of Saturn's F Ring

    NASA Astrophysics Data System (ADS)

    Becker, T. M.; Colwell, J.; Esposito, L. W.

    2011-12-01

    Saturn's beauty is often attributed to the magnificent rings that encircle the planet. Although admired for hundreds of years, we are now just beginning to understand the complexity of the rings as a result of new data from the Cassini orbiter. Studying occultations of the rings provides information about the distribution and sizes of the particles that define the rings. During one solar occultation, the Ultraviolet Imaging Spectrograph (UVIS) on board Cassini was slightly misaligned with the Sun, decreasing the amount of direct solar signal to ~1% of the normal value. As a result, UVIS detected a peak in photon counts above the non-occulted signal due to forward-scattered light diffracted by the small particles in the F Ring. There is a direct relationship between the size of the particles and the intensity of the light scattered. We utilize this relationship in a model that replicates the misalignment and calculates the amount of light that would be detected as a function of the particle sizes in the ring. We present new results from the model that constrain the size distribution of the dynamically active F Ring, contributing to the study of the origin and evolution of Saturn's ring system.

  14. BEAUTY: an enhanced BLAST-based search tool that integrates multiple biological information resources into sequence similarity search results.

    PubMed

    Worley, K C; Wiese, B A; Smith, R F

    1995-09-01

    BEAUTY (BLAST enhanced alignment utility) is an enhanced version of the NCBI's BLAST data base search tool that facilitates identification of the functions of matched sequences. We have created new data bases of conserved regions and functional domains for protein sequences in NCBI's Entrez data base, and BEAUTY allows this information to be incorporated directly into BLAST search results. A Conserved Regions Data Base, containing the locations of conserved regions within Entrez protein sequences, was constructed by (1) clustering the entire data base into families, (2) aligning each family using our PIMA multiple sequence alignment program, and (3) scanning the multiple alignments to locate the conserved regions within each aligned sequence. A separate Annotated Domains Data Base was constructed by extracting the locations of all annotated domains and sites from sequences represented in the Entrez, PROSITE, BLOCKS, and PRINTS data bases. BEAUTY performs a BLAST search of those Entrez sequences with conserved regions and/or annotated domains. BEAUTY then uses the information from the Conserved Regions and Annotated Domains data bases to generate, for each matched sequence, a schematic display that allows one to directly compare the relative locations of (1) the conserved regions, (2) annotated domains and sites, and (3) the locally aligned regions matched in the BLAST search. In addition, BEAUTY search results include World-Wide Web hypertext links to a number of external data bases that provide a variety of additional types of information on the function of matched sequences. This convenient integration of protein families, conserved regions, annotated domains, alignment displays, and World-Wide Web resources greatly enhances the biological informativeness of sequence similarity searches. BEAUTY searches can be performed remotely on our system using the "BCM Search Launcher" World-Wide Web pages (URL is < http:/ /gc.bcm.tmc.edu:8088/ search

  15. Simple estimates of the masses of pentaquarks with hidden beauty or strangeness

    NASA Astrophysics Data System (ADS)

    Kopeliovich, Vladimir; Potashnikova, Irina

    2016-04-01

    The masses of cryptoexotic pentaquarks with hidden beauty are estimated phenomenologically using the results by the LHCb Collaboration which discovered recently the cryptoexotic pentaquarks with hidden charm. The expected masses of the hidden beauty pentaquarks are about 10.8 GeV and 10.7 GeV in the limit of some kind of heavy quark symmetry. The states with hidden strangeness considered in a similar way have masses of about 2.37 GeV and 2.30 GeV, several hundred MeV higher than states discussed previously in connection with the relatively light positive strangeness pentaquark θ+. Empirical data on the spectra of pentaquarks can be used to get information about quarkonia interaction with nucleons. The results obtained for the case of heavy flavors are in fair agreement with the model of isospin (pion) exchange between flavored baryons and antiflavored vector mesons proposed by Karliner and Rosner, and in qualitative agreement with the bound-state version of the chiral soliton model.

  16. Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy.

    PubMed

    Ganesan, Palanivel; Choi, Dong-Kug

    2016-01-01

    Phytocompounds have been used in cosmeceuticals for decades and have shown potential for beauty applications, including sunscreen, moisturizing and antiaging, and skin-based therapy. The major concerns in the usage of phyto-based cosmeceuticals are lower penetration and high compound instability of various cosmetic products for sustained and enhanced compound delivery to the beauty-based skin therapy. To overcome these disadvantages, nanosized delivery technologies are currently in use for sustained and enhanced delivery of phyto-derived bioactive compounds in cosmeceutical sectors and products. Nanosizing of phytocompounds enhances the aseptic feel in various cosmeceutical products with sustained delivery and enhanced skin protecting activities. Solid lipid nanoparticles, transfersomes, ethosomes, nanostructured lipid carriers, fullerenes, and carbon nanotubes are some of the emerging nanotechnologies currently in use for their enhanced delivery of phytocompounds in skin care. Aloe vera, curcumin, resveratrol, quercetin, vitamins C and E, genistein, and green tea catechins were successfully nanosized using various delivery technologies and incorporated in various gels, lotions, and creams for skin, lip, and hair care for their sustained effects. However, certain delivery agents such as carbon nanotubes need to be studied for their roles in toxicity. This review broadly focuses on the usage of phytocompounds in various cosmeceutical products, nanodelivery technologies used in the delivery of phytocompounds to various cosmeceuticals, and various nanosized phytocompounds used in the development of novel nanocosmeceuticals to enhance skin-based therapy. PMID:27274231

  17. Efficient mammalian germline transgenesis by cis-enhanced Sleeping Beauty transposition.

    PubMed

    Carlson, Daniel F; Geurts, Aron M; Garbe, John R; Park, Chang-Won; Rangel-Filho, Artur; O'Grady, Scott M; Jacob, Howard J; Steer, Clifford J; Largaespada, David A; Fahrenkrug, Scott C

    2011-02-01

    Heightened interest in relevant models for human disease increases the need for improved methods for germline transgenesis. We describe a significant improvement in the creation of transgenic laboratory mice and rats by chemical modification of Sleeping Beauty transposons. Germline transgenesis in mice and rats was significantly enhanced by in vitro cytosine-phosphodiester-guanine methylation of transposons prior to injection. Heritability of transgene alleles was also greater from founder mice generated with methylated versus non-methylated transposon. The artificial methylation was reprogrammed in the early embryo, leading to founders that express the transgenes. We also noted differences in transgene insertion number and structure (single-insert versus concatemer) based on the influence of methylation and plasmid conformation (linear versus supercoiled), with supercoiled substrate resulting in efficient transpositional transgenesis (TnT) with near elimination of concatemer insertion. Combined, these substrate modifications resulted in increases in both the frequency of transgenic founders and the number of transgenes per founder, significantly elevating the number of potential transgenic lines. Given its simplicity, versatility and high efficiency, TnT with enhanced Sleeping Beauty components represents a compelling non-viral approach to modifying the mammalian germline. PMID:20352328

  18. Facial beauty affects implicit and explicit learning of men and women differently

    PubMed Central

    Ziori, Eleni; Dienes, Zoltán

    2015-01-01

    The present work explores the unconscious and/or conscious nature of learning attractive faces of same and opposite sex, that is, of stimuli that experimental and neuroimaging research has shown to be rewarding and thus highly motivating. To this end, we examined performance of men and women while classifying strings of average and attractive faces for grammaticality in the experimental task of artificial grammar learning (AGL), which reflects both conscious and unconscious processes. Subjective measures were used to assess participants’ conscious and unconscious knowledge. It was found that female attractiveness impaired performance in male participants. In particular, male participants demonstrated the lowest accuracy while classifying beautiful faces of women. Conversely, female attractiveness facilitated performance in female participants. The pattern was similar for conscious and unconscious knowledge. Presumably, objects with high incentive salience, as are beautiful faces, captured resources, which were used in task relevant versus task irrelevant ways by women versus men. The present findings shed light on the relation of conscious and unconscious processing with affective and reward-related stimuli, as well as on gender differences underlying this relation. PMID:26300819

  19. Baby beautiful: adult attributions of infant competence as a function of infant attractiveness.

    PubMed

    Stephan, C W; Langlois, J H

    1984-04-01

    To determine at what age children first elicit differential expectations from adults as a function of their appearance, a sample of black, Caucasian, and Mexican-American adults rated photographs of a sample of black, Caucasian, and Mexican-American infants at 3 time periods in the first year of life. These adults first rated the infants on physical attractiveness and then rated the infants on 12 bipolar adjectives. The adjectives were reduced to 4 dimensions of infant behavior by factor analysis. A strong beauty-is-good stereotype was associated with 3 of the dimensions. On the measures of smart - likable baby, good baby, and causes parents problems, there was a beauty-is-good bias that prevailed across ethnic groups. In contrast, no such bias was found on the measure of active baby. The activity index was expected to reflect positive characteristics, but it appears to have implied overactivity and irritability. Strong and consistent expectations for behavior of attractive and unattractive individuals thus appear to be elicited soon after birth in Caucasian and non-Caucasian populations. PMID:6723448

  20. Compositeness of the strange, charm, and beauty odd parity Λ states

    NASA Astrophysics Data System (ADS)

    Garcia-Recio, C.; Hidalgo-Duque, C.; Nieves, J.; Salcedo, L. L.; Tolos, L.

    2015-08-01

    We study the dependence on the quark mass of the compositeness of the lowest-lying odd parity hyperon states. Thus, we pay attention to Λ -like states in the strange, charm, and beauty sectors which are dynamically generated using a unitarized meson-baryon model. In the strange sector we use a SU(6) extension of the Weinberg-Tomozawa meson-baryon interaction, and we further implement the heavy-quark spin symmetry to construct the meson-baryon interaction when charmed or beauty hadrons are involved. In the three examined flavor sectors, we obtain two JP=1 /2- and one JP=3 /2- Λ states. We find that the Λ states which are bound states (the three Λb) or narrow resonances [one Λ (1405 ) and one Λc(2595 )] are well described as molecular states composed of s -wave meson-baryon pairs. The 1/2- wide Λ (1405 ) and Λc(2595 ) as well as the 3/2- Λ (1520 ) and Λc(2625 ) states display smaller compositeness so they would require new mechanisms, such as d -wave interactions.

  1. Facial beauty affects implicit and explicit learning of men and women differently.

    PubMed

    Ziori, Eleni; Dienes, Zoltán

    2015-01-01

    The present work explores the unconscious and/or conscious nature of learning attractive faces of same and opposite sex, that is, of stimuli that experimental and neuroimaging research has shown to be rewarding and thus highly motivating. To this end, we examined performance of men and women while classifying strings of average and attractive faces for grammaticality in the experimental task of artificial grammar learning (AGL), which reflects both conscious and unconscious processes. Subjective measures were used to assess participants' conscious and unconscious knowledge. It was found that female attractiveness impaired performance in male participants. In particular, male participants demonstrated the lowest accuracy while classifying beautiful faces of women. Conversely, female attractiveness facilitated performance in female participants. The pattern was similar for conscious and unconscious knowledge. Presumably, objects with high incentive salience, as are beautiful faces, captured resources, which were used in task relevant versus task irrelevant ways by women versus men. The present findings shed light on the relation of conscious and unconscious processing with affective and reward-related stimuli, as well as on gender differences underlying this relation. PMID:26300819

  2. Studies of beauty baryon decays to D0ph- and Λc+h- final states

    NASA Astrophysics Data System (ADS)

    Aaij, R.; Adeva, B.; Adinolfi, M.; Adrover, C.; Affolder, A.; Ajaltouni, Z.; Albrecht, J.; Alessio, F.; Alexander, M.; Ali, S.; Alkhazov, G.; Alvarez Cartelle, P.; Alves, A. A.; Amato, S.; Amerio, S.; Amhis, Y.; Anderlini, L.; Anderson, J.; Andreassen, R.; Andreotti, M.; Andrews, J. E.; Appleby, R. B.; Aquines Gutierrez, O.; Archilli, F.; Artamonov, A.; Artuso, M.; Aslanides, E.; Auriemma, G.; Baalouch, M.; Bachmann, S.; Back, J. J.; Badalov, A.; Balagura, V.; Baldini, W.; Barlow, R. J.; Barschel, C.; Barsuk, S.; Barter, W.; Batozskaya, V.; Bauer, Th.; Bay, A.; Beddow, J.; Bedeschi, F.; Bediaga, I.; Belogurov, S.; Belous, K.; Belyaev, I.; Ben-Haim, E.; Bencivenni, G.; Benson, S.; Benton, J.; Berezhnoy, A.; Bernet, R.; Bettler, M.-O.; van Beuzekom, M.; Bien, A.; Bifani, S.; Bird, T.; Bizzeti, A.; Bjørnstad, P. M.; Blake, T.; Blanc, F.; Blouw, J.; Blusk, S.; Bocci, V.; Bondar, A.; Bondar, N.; Bonivento, W.; Borghi, S.; Borgia, A.; Bowcock, T. J. V.; Bowen, E.; Bozzi, C.; Brambach, T.; van den Brand, J.; Bressieux, J.; Brett, D.; Britsch, M.; Britton, T.; Brook, N. H.; Brown, H.; Bursche, A.; Busetto, G.; Buytaert, J.; Cadeddu, S.; Calabrese, R.; Callot, O.; Calvi, M.; Calvo Gomez, M.; Camboni, A.; Campana, P.; Campora Perez, D.; Carbone, A.; Carboni, G.; Cardinale, R.; Cardini, A.; Carranza-Mejia, H.; Carson, L.; Carvalho Akiba, K.; Casse, G.; Castillo Garcia, L.; Cattaneo, M.; Cauet, Ch.; Cenci, R.; Charles, M.; Charpentier, Ph.; Cheung, S.-F.; Chiapolini, N.; Chrzaszcz, M.; Ciba, K.; Cid Vidal, X.; Ciezarek, G.; Clarke, P. E. L.; Clemencic, M.; Cliff, H. V.; Closier, J.; Coca, C.; Coco, V.; Cogan, J.; Cogneras, E.; Collins, P.; Comerma-Montells, A.; Contu, A.; Cook, A.; Coombes, M.; Coquereau, S.; Corti, G.; Couturier, B.; Cowan, G. A.; Craik, D. C.; Cruz Torres, M.; Cunliffe, S.; Currie, R.; D'Ambrosio, C.; Dalseno, J.; David, P.; David, P. N. Y.; Davis, A.; De Bonis, I.; De Bruyn, K.; De Capua, S.; De Cian, M.; De Miranda, J. M.; De Paula, L.; De Silva, W.; De Simone, P.; Decamp, D.; Deckenhoff, M.; Del Buono, L.; Déléage, N.; Derkach, D.; Deschamps, O.; Dettori, F.; Di Canto, A.; Dijkstra, H.; Dogaru, M.; Donleavy, S.; Dordei, F.; Dorosz, P.; Dosil Suárez, A.; Dossett, D.; Dovbnya, A.; Dupertuis, F.; Durante, P.; Dzhelyadin, R.; Dziurda, A.; Dzyuba, A.; Easo, S.; Egede, U.; Egorychev, V.; Eidelman, S.; van Eijk, D.; Eisenhardt, S.; Eitschberger, U.; Ekelhof, R.; Eklund, L.; El Rifai, I.; Elsasser, Ch.; Falabella, A.; Färber, C.; Farinelli, C.; Farry, S.; Ferguson, D.; Fernandez Albor, V.; Ferreira Rodrigues, F.; Ferro-Luzzi, M.; Filippov, S.; Fiore, M.; Fiorini, M.; Fitzpatrick, C.; Fontana, M.; Fontanelli, F.; Forty, R.; Francisco, O.; Frank, M.; Frei, C.; Frosini, M.; Furfaro, E.; Gallas Torreira, A.; Galli, D.; Gandelman, M.; Gandini, P.; Gao, Y.; Garofoli, J.; Garosi, P.; Garra Tico, J.; Garrido, L.; Gaspar, C.; Gauld, R.; Gersabeck, E.; Gersabeck, M.; Gershon, T.; Ghez, Ph.; Gibson, V.; Giubega, L.; Gligorov, V. V.; Göbel, C.; Golubkov, D.; Golutvin, A.; Gomes, A.; Gordon, H.; Grabalosa Gándara, M.; Graciani Diaz, R.; Granado Cardoso, L. A.; Graugés, E.; Graziani, G.; Grecu, A.; Greening, E.; Gregson, S.; Griffith, P.; Grillo, L.; Grünberg, O.; Gui, B.; Gushchin, E.; Guz, Yu.; Gys, T.; Hadjivasiliou, C.; Haefeli, G.; Haen, C.; Hafkenscheid, T. W.; Haines, S. C.; Hall, S.; Hamilton, B.; Hampson, T.; Hansmann-Menzemer, S.; Harnew, N.; Harnew, S. T.; Harrison, J.; Hartmann, T.; He, J.; Head, T.; Heijne, V.; Hennessy, K.; Henrard, P.; Hernando Morata, J. A.; van Herwijnen, E.; Heß, M.; Hicheur, A.; Hicks, E.; Hill, D.; Hoballah, M.; Hombach, C.; Hulsbergen, W.; Hunt, P.; Huse, T.; Hussain, N.; Hutchcroft, D.; Hynds, D.; Iakovenko, V.; Idzik, M.; Ilten, P.; Jacobsson, R.; Jaeger, A.; Jans, E.; Jaton, P.; Jawahery, A.; Jing, F.; John, M.; Johnson, D.; Jones, C. R.; Joram, C.; Jost, B.; Jurik, N.; Kaballo, M.; Kandybei, S.; Kanso, W.; Karacson, M.; Karbach, T. M.; Kenyon, I. R.; Ketel, T.; Khanji, B.; Klaver, S.; Kochebina, O.; Komarov, I.; Koopman, R. F.; Koppenburg, P.; Korolev, M.; Kozlinskiy, A.; Kravchuk, L.; Kreplin, K.; Kreps, M.; Krocker, G.; Krokovny, P.; Kruse, F.; Kucharczyk, M.; Kudryavtsev, V.; Kurek, K.; Kvaratskheliya, T.; La Thi, V. N.; Lacarrere, D.; Lafferty, G.; Lai, A.; Lambert, D.; Lambert, R. W.; Lanciotti, E.; Lanfranchi, G.; Langenbruch, C.; Latham, T.; Lazzeroni, C.; Le Gac, R.; van Leerdam, J.; Lees, J.-P.; Lefèvre, R.; Leflat, A.; Lefrançois, J.; Leo, S.; Leroy, O.; Lesiak, T.; Leverington, B.; Li, Y.; Li Gioi, L.; Liles, M.; Lindner, R.; Linn, C.; Lionetto, F.; Liu, B.; Liu, G.; Lohn, S.; Longstaff, I.; Lopes, J. H.; Lopez-March, N.; Lu, H.; Lucchesi, D.; Luisier, J.; Luo, H.; Luppi, E.; Lupton, O.; Machefert, F.; Machikhiliyan, I. V.; Maciuc, F.; Maev, O.; Malde, S.

    2014-02-01

    Decays of beauty baryons to the D0ph- and Λc+h- final states (where h indicates a pion or a kaon) are studied using a data sample of pp collisions, corresponding to an integrated luminosity of 1.0 fb-1, collected by the LHCb detector. The Cabibbo-suppressed decays Λb0→D0pK- and Λb0→Λc+K- are observed, and their branching fractions are measured with respect to the decays Λb0→D0pπ- and Λb0→Λc+π-. In addition, the first observation is reported of the decay of the neutral beauty-strange baryon Ξb0 to the D0pK- final state, and a measurement of the Ξb0 mass is performed. Evidence of the Ξb0→Λc+K- decay is also reported.

  3. Complete mitogenomes of Guinean angelfish (Holacanthus africanus) and Rock beauty (Holacanthus tricolor) (Teleostei: Pomacanthidae).

    PubMed

    Shen, Kang-Ning; Chen, Ching-Hung; Hsiao, Chung-Der

    2016-07-01

    In this study, we used the next-generation sequencing method to deduce two complete mitogenomes of Guinean angelfish (Holacanthus africanus) and Rock beauty (Holacanthus tricolor) for the first time. The assembled mitogenome, consisting of 16,819 bp and 16,625 bp in length, shows 87% similarity with each other. Both mitogenomes follow the typical vertebrate arrangement, including 13 protein-coding genes, 22 transfer RNAs, 2 ribosomal RNAs genes, and a non-coding control region of D-loop. The D-loop contains 1107 bp in H. africanus and 905 bp in H. tricolor and is located between tRNA-Pro and tRNA-Phe. The overall GC content is 46.2% for H. africanus and 45.6% for H. tricolor. The complete mitogenome of Guinean angelfish and Rock beauty deduced in this study provides essential and important DNA molecular data for further phylogenetic and evolutionary analysis for marine angelfish. PMID:26114323

  4. Shared brain activity for aesthetic and moral judgments: implications for the Beauty-is-Good stereotype

    PubMed Central

    Cabeza, Roberto

    2011-01-01

    The Beauty-is-Good stereotype refers to the assumption that attractive people possess sociably desirable personalities and higher moral standards. The existence of this bias suggests that the neural mechanisms for judging facial attractiveness and moral goodness overlap. To investigate this idea, we scanned participants with functional magnetic resonance imaging while they made attractiveness judgments about faces and goodness judgments about hypothetical actions. Activity in the medial orbitofrontal cortex increased as a function of both attractiveness and goodness ratings, whereas activity in the insular cortex decreased with both attractiveness and goodness ratings. Within each of these regions, the activations elicited by attractiveness and goodness judgments were strongly correlated with each other, supporting the idea of similar contributions of each region to both judgments. Moreover, activations in orbitofrontal and insular cortices were negatively correlated with each other, suggesting an opposing relationship between these regions during attractiveness and goodness judgments. These findings have implications for understanding the neural mechanisms of the Beauty-is-Good stereotype. PMID:20231177

  5. Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy

    PubMed Central

    Ganesan, Palanivel; Choi, Dong-Kug

    2016-01-01

    Phytocompounds have been used in cosmeceuticals for decades and have shown potential for beauty applications, including sunscreen, moisturizing and antiaging, and skin-based therapy. The major concerns in the usage of phyto-based cosmeceuticals are lower penetration and high compound instability of various cosmetic products for sustained and enhanced compound delivery to the beauty-based skin therapy. To overcome these disadvantages, nanosized delivery technologies are currently in use for sustained and enhanced delivery of phyto-derived bioactive compounds in cosmeceutical sectors and products. Nanosizing of phytocompounds enhances the aseptic feel in various cosmeceutical products with sustained delivery and enhanced skin protecting activities. Solid lipid nanoparticles, transfersomes, ethosomes, nanostructured lipid carriers, fullerenes, and carbon nanotubes are some of the emerging nanotechnologies currently in use for their enhanced delivery of phytocompounds in skin care. Aloe vera, curcumin, resveratrol, quercetin, vitamins C and E, genistein, and green tea catechins were successfully nanosized using various delivery technologies and incorporated in various gels, lotions, and creams for skin, lip, and hair care for their sustained effects. However, certain delivery agents such as carbon nanotubes need to be studied for their roles in toxicity. This review broadly focuses on the usage of phytocompounds in various cosmeceutical products, nanodelivery technologies used in the delivery of phytocompounds to various cosmeceuticals, and various nanosized phytocompounds used in the development of novel nanocosmeceuticals to enhance skin-based therapy. PMID:27274231

  6. Magnetic particles

    NASA Technical Reports Server (NTRS)

    Chang, Manchium (Inventor); Colvin, Michael S. (Inventor); Rembaum, Alan (Inventor); Richards, Gil F. (Inventor)

    1987-01-01

    Metal oxide containing polymers and particularly styrene, acrylic or protein polymers containing fine, magnetic iron oxide particles are formed by combining a NO.sub.2 -substituted polymer with an acid such as hydrochloric acid in the presence of metal, particularly iron particles. The iron is oxidized to fine, black Fe.sub.3 O.sub.4 particles which deposit selectively on the polymer particles. Nitrated polymers are formed by reacting functionally substituted, nitrated organic compounds such as trinitrobenzene sulfonate or dinitrofluoro benzene with a functionally coreactive polymer such as an amine modified acrylic polymer or a protein. Other transition metals such as cobalt can also be incorporated into polymers using this method.

  7. Elementary Particles

    ERIC Educational Resources Information Center

    Parham, R.

    1974-01-01

    Presents the text of a speech given to a conference of physics teachers in which the full spectrum of elementary particles is given, along with their classification. Also includes some teaching materials available on this topic. (PEB)

  8. Elementary particles

    NASA Astrophysics Data System (ADS)

    Fritzsch, Harald; Heusch, Karin

    Introduction -- Electrons and atomic nuclei -- Quantum properties of atoms and particles -- The knives of Democritus -- Quarks inside atomic nuclei -- Quantum electrodynamics -- Quantum chromodynamics -- Mesons, baryons, and quarks -- Electroweak interactions -- Grand unification -- Conclusion.

  9. Auroral particles

    NASA Technical Reports Server (NTRS)

    Evans, David S.

    1987-01-01

    The problems concerning the aurora posed prior to the war are now either solved in principle or were restated in a more fundamental form. The pre-war hypothesis concerning the nature of the auroral particles and their energies was fully confirmed, with the exception that helium and oxygen ions were identified as participating in the auroral particle precipitation in addition to the protons. The nature of the near-Earth energization processes affecting auroral particles was clarified. Charged particle trajectories in various electric field geometries were modeled. The physical problems have now moved from determining the nature and geometry of the electric fields, which accelerate charged particles near the Earth, to accounting for the existence of these electric fields as a natural consequence of the solar wind's interaction with Earth. Ultimately the reward in continuing the work in auroral and magnetospheric particle dynamics will be a deeper understanding of the subtleties of classical electricity and magnetism as applied to situations not blessed with well-defined and invariant geometries.

  10. Beautifully strange

    NASA Astrophysics Data System (ADS)

    2009-04-01

    The list of famous Bristolians is an illustrious one. The Victorian engineer Isambard Kingdom Brunel, for example, is recognized everywhere in Bristol for his many iconic structures, even though he was not born, bred or even resident in the city. Another well-known son of the city is the Hollywood legend Cary Grant, born as Archie Leach in the suburb of Horfield and now commemorated with a striking bronze statue outside Bristol's hands-on science museum. The physicist Paul Dirac actually went to the same elementary school as Grant/Leach, and the abstract sculpture dedicated to him stands just a stone's throw away from Grant's bronze likeness. Dirac also has a building named after him: Dirac House, the headquarters of IOP Publishing (which publishes Physics World).

  11. Natural Beauty

    ERIC Educational Resources Information Center

    Coy, Mary

    2006-01-01

    In this article, the author describes how her art class students were able to create, in just four class periods, clay relief plaques depicting nature. A lesson on texture speeds up the completion of such a project. Seeing that clay is a natural material with its own unique texture, it seemed fitting that the final product should depict a variety…

  12. Truth-Beauty-Goodness: Philosophy Units for Gifted Students (Middle and Secondary Grade Levels). Programs for Gifted Students.

    ERIC Educational Resources Information Center

    Kolman, Peter

    This document, one in a series of nine units of study developed for middle and junior high school gifted students outlines an introduction to philosophy based on Mortimer Adler's conceptions. Adler simplified the study of logic into the study of truth, the study of aesthetics to that of beauty, and distilled the study of ethics to the study of…

  13. When We like What We Know--A Parametric fMRI Analysis of Beauty and Familiarity

    ERIC Educational Resources Information Center

    Bohrn, Isabel C.; Altmann, Ulrike; Lubrich, Oliver; Menninghaus, Winfried; Jacobs, Arthur M.

    2013-01-01

    This paper presents a neuroscientific study of aesthetic judgments on written texts. In an fMRI experiment participants read a number of proverbs without explicitly evaluating them. In a post-scan rating they rated each item for familiarity and beauty. These individual ratings were correlated with the functional data to investigate the neural…

  14. 77 FR 3035 - Pricing for 2012 Annual Sets and America the Beautiful Quarters® Bags & Rolls

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-20

    ... United States Mint Pricing for 2012 Annual Sets and America the Beautiful Quarters Bags & Rolls AGENCY: United States Mint, Department of the Treasury. ACTION: Notice. SUMMARY: The United States Mint is... table below. Retail Product Price 2012 United States Mint Proof Set $31.95 2012 United States...

  15. 78 FR 30398 - Re-pricing of the 2012 and 2013 United States America the Beautiful Quarters Silver Proof Set...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-22

    ... United States Mint Re-pricing of the 2012 and 2013 United States America the Beautiful Quarters Silver Proof Set , 2013 United States Mint Silver Proof Set , and 2013 United States Mint Congratulations Set... Silver Proof Set, the 2013 United States Mint Silver Proof Set, and the 2013 United States...

  16. Collaborating with Extreme Beauty: A Partnership Project between the Heritage School and the Metropolitan Museum of Art

    ERIC Educational Resources Information Center

    Hochtritt, Lisa; Lane, Kimberly; Price, Shannon Bell

    2004-01-01

    This article chronicles the development and implementation of a lesson sequence in a high school art course that utilized "Extreme Beauty: The Body Transformed," a special exhibition at the Metropolitan Museum of Art's Costume Institute from December 6, 2001-March 17, 2002. This project took place over a 3-week period in the spring semester 2002…

  17. 77 FR 2341 - Culturally Significant Objects Imported for Exhibition Determinations: “The Cult of Beauty: The...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``The Cult of Beauty: The Victorian... April 15, 2003), I hereby determine that the objects to be included in the exhibition ``The Cult...

  18. Charm and beauty searches using electron -D{sup 0} azimuthal correlations and microvertexing techniques in STAR experiment at RHIC

    SciTech Connect

    Geromitsos, Artemios

    2010-12-22

    The energy loss of heavy quarks in the hot and dense matter created at RHIC, can be used to probe the properties of the medium. Both charm and beauty quarks contribute to the non-photonic electrons through their semi-leptonic decays. It is essential to determine experimentally the relative contribution of charm and beauty quarks to understand the suppression of heavy flavors at high p{sub T} in central Au+Au collisions. The azimuthal angular correlations of non-photonic electrons with the reconstructed D{sup 0} allow to disentangle the contribution of charm and beauty and to reduce the background below the D{sup 0} invariant mass as well. We discuss the STAR measurement of non-photonic electron and D{sup 0{yields}}K{sup -{pi}+} azimuthal correlations in p+p collisions at 200 GeV. Furthermore, we show results from the application of microvertexing techniques for charm and beauty searches in Cu+Cu and Au+Au collisions at 200 GeV using the information of the Silicon tracker of STAR.

  19. Behind the Curtain of the Beauty Pageant: An Investigation of U.S. News Undergraduate Business Program Rankings

    ERIC Educational Resources Information Center

    Perry, Pam

    2010-01-01

    The undergraduate business program rankings in USNWR are based solely on peer assessments from deans and associate deans of AACSB accredited U.S. business schools. Often these reputation-based rankings are discounted and likened to a beauty pageant because the process lacks transparent input data. In this study, ten deans and ten associate…

  20. Carbon particles

    DOEpatents

    Hunt, Arlon J.

    1984-01-01

    A method and apparatus whereby small carbon particles are made by pyrolysis of a mixture of acetylene carried in argon. The mixture is injected through a nozzle into a heated tube. A small amount of air is added to the mixture. In order to prevent carbon build-up at the nozzle, the nozzle tip is externally cooled. The tube is also elongated sufficiently to assure efficient pyrolysis at the desired flow rates. A key feature of the method is that the acetylene and argon, for example, are premixed in a dilute ratio, and such mixture is injected while cool to minimize the agglomeration of the particles, which produces carbon particles with desired optical properties for use as a solar radiant heat absorber.

  1. Particle Sizer

    NASA Technical Reports Server (NTRS)

    1987-01-01

    Microspheres are tiny plastic beads that represent the first commercial products manufactured in orbit. An example of how they are used is a new aerodynamic particle sizer designated APS 33B produced by TSI Incorporated. TSI purchased the microspheres from the National Bureau of Standards which certified their exact size and the company uses them in calibration of the APS 33B* instrument, latest in a line of TSI systems for generating counting and weighing minute particles of submicron size. Instruments are used for evaluating air pollution control devices, quantifying environments, meteorological research, testing filters, inhalation, toxicology and other areas where generation or analysis of small airborne particles is required. * The APS 33B is no longer being manufactured. An improved version, APS 3320, is now being manufactured. 2/28/97

  2. Beautiful Earth: Inspiring Native American students in Earth Science through Music, Art and Science

    NASA Astrophysics Data System (ADS)

    Casasanto, V.; Rock, J.; Hallowell, R.; Williams, K.; Angell, D.; Beautiful Earth

    2011-12-01

    The Beautiful Earth program, awarded by NASA's Competitive Opportunities in Education and Public Outreach for Earth and Space Science (EPOESS), is a live multi-media performance at partner science centers linked with hands-on workshops featuring Earth scientists and Native American experts. It aims to inspire, engage and educate diverse students in Earth science through an experience of viewing the Earth from space as one interconnected whole, as seen through the eyes of astronauts. The informal education program is an outgrowth of Kenji Williams' BELLA GAIA Living Atlas Experience (www.bellagaia.com) performed across the globe since 2008 and following the successful Earth Day education events in 2009 and 2010 with NASA's DLN (Digital Learning Network) http://tinyurl.com/2ckg2rh. Beautiful Earth takes a new approach to teaching, by combining live music and data visualizations, Earth Science with indigenous perspectives of the Earth, and hands-on interactive workshops. The program will utilize the emotionally inspiring multi-media show as a springboard to inspire participants to learn more about Earth systems and science. Native Earth Ways (NEW) will be the first module in a series of three "Beautiful Earth" experiences, that will launch the national tour at a presentation in October 2011 at the MOST science museum in collaboration with the Onandaga Nation School in Syracuse, New York. The NEW Module will include Native American experts to explain how they study and conserve the Earth in their own unique ways along with hands-on activities to convey the science which was seen in the show. In this first pilot run of the module, 110 K-12 students with faculty and family members of the Onandaga Nations School will take part. The goal of the program is to introduce Native American students to Earth Sciences and STEM careers, and encourage them to study these sciences and become responsible stewards of the Earth. The second workshop presented to participants will be the

  3. Particle Imaging, Characterization and Extinction Measurement with Digital Holography

    NASA Astrophysics Data System (ADS)

    Subedi, Nava; Berg, Matthew

    2015-03-01

    Digital holographic microcopy (DHM) can be a ground breaking technique in the field of particle diagnostic because of its capability for imaging, characterization and extinction measurement in situ. The beauty of this technique is that a single experimental set up is able to do all these works at the same time. In this sense DHM can be used to establish a new kind of instrumentation having the properties of cost-effective, light-weight and portable. Besides this, this technique also has lots of useful applications in the field of aerosol research, climate modeling, life science, polymer crystallization, and defense. We are using DHM for sub-micron sized particle imaging, characterization and extinction. In this work, a particle is illuminated by a pulsed laser and the interference pattern produced by superposition of particle's forward-scattered wave with the incident wave is recorded by a digital camera. The recorded pattern constitutes a digital hologram which can be numerically processed to get image, composition information and extinction cross-section of the particle. These information of the particle are the basic requirements for the characterization of respirable-sized (1-10 μm) aerosols particles.

  4. Virion-associated cofactor high-mobility group DNA-binding protein-1 facilitates transposition from the herpes simplex virus/Sleeping Beauty amplicon vector platform.

    PubMed

    de Silva, Suresh; Lotta, Louis T; Burris, Clark A; Bowers, William J

    2010-11-01

    The development of the integration-competent, herpes simplex virus/Sleeping Beauty (HSV/SB) amplicon vector platform has created a means to efficiently and stably deliver therapeutic transcription units (termed "transgenons") to neurons within the mammalian brain. Furthermore, an investigation into the transposition capacity of the HSV/SB vector system revealed that the amplicon genome provides an optimal substrate for the transposition of transgenons at least 12 kb in length [de Silva, S., Mastrangelo, M.A., Lotta, L.T., Jr., Burris, C.A., Federoff, H.J., and Bowers, W.J. ( 2010 ). Gene Ther. 17, 424-431]. These results prompted an investigation into the factors that may contribute toward efficient transposition from the HSV/SB amplicon. One of the cellular cofactors known to play a key role during SB-mediated transposition is the high-mobility group DNA-binding protein-1 (HMGB1). Our present investigation into the role of HMGB1 during amplicon-based transposition revealed that transposition is not strictly dependent on the presence of cellular HMGB1, contrary to what had been previously demonstrated with plasmid-based SB transposition. We have shown for the first time that during amplicon preparation, biologically active HMGB1 derived from the packaging cell line is copackaged into amplicon vector particles. As a result, HSV/SB amplicon virions arrive prearmed with HMGB1 protein at levels sufficient for facilitating SB-mediated transposition in the transduced mammalian cell. PMID:20568967

  5. Particle blender

    DOEpatents

    Willey, Melvin G.

    1981-01-01

    An infinite blender that achieves a homogeneous mixture of fuel microspheres is provided. Blending is accomplished by directing respective groups of desired particles onto the apex of a stationary coaxial cone. The particles progress downward over the cone surface and deposit in a space at the base of the cone that is described by a flexible band provided with a wide portion traversing and in continuous contact with the circumference of the cone base and extending upwardly therefrom. The band, being attached to the cone at a narrow inner end thereof, causes the cone to rotate on its arbor when the band is subsequently pulled onto a take-up spool. As a point at the end of the wide portion of the band passes the point where it is tangent to the cone, the blended particles are released into a delivery tube leading directly into a mold, and a plate mounted on the lower portion of the cone and positioned between the end of the wide portion of the band and the cone assures release of the particles only at the tangent point.

  6. PARTICLE ACCELERATOR

    DOEpatents

    Teng, L.C.

    1960-01-19

    ABS>A combination of two accelerators, a cyclotron and a ring-shaped accelerator which has a portion disposed tangentially to the cyclotron, is described. Means are provided to transfer particles from the cyclotron to the ring accelerator including a magnetic deflector within the cyclotron, a magnetic shield between the ring accelerator and the cyclotron, and a magnetic inflector within the ring accelerator.

  7. Particle astrophysics

    SciTech Connect

    Sadoulet, B. |

    1992-12-31

    In the last few years, particle astrophysics has emerged as a new field at the frontier between high energy astrophysics, cosmology, and particle physics. Two spectacular achievements of this new field in the last decade have been the establishment of neutrino astronomy with the detection of solar neutrinos by two independent experiments and the spectacular observation of the neutrinos from the supernova SN1987A. In addition, the field has produced tantalizing hints of new physics beyond the standard models of astrophysics and particle physics, generating enthusiastic attempts to confirm these potential effects. This new field involves some two hundred experimentalists and a similar number of theorists, most of them coming from particle and nuclear physics, and as scientist will see, their effort is to a large extent complementary to accelerator based high energy physics. This review attempts, at the beginning of this workshop, to capture the excitement of this new field. Summary talks will describe in more detail some of the topics discussed in the study groups.

  8. Beauty and the brain: culture, history and individual differences in aesthetic appreciation.

    PubMed

    Jacobsen, Thomas

    2010-02-01

    Human aesthetic processing entails the sensation-based evaluation of an entity with respect to concepts like beauty, harmony or well-formedness. Aesthetic appreciation has many determinants ranging from evolutionary, anatomical or physiological constraints to influences of culture, history and individual differences. There are a vast number of dynamically configured neural networks underlying these multifaceted processes of aesthetic appreciation. In the current challenge of successfully bridging art and science, aesthetics and neuroanatomy, the neuro-cognitive psychology of aesthetics can approach this complex topic using a framework that postulates several perspectives, which are not mutually exclusive. In this empirical approach, objective physiological data from event-related brain potentials and functional magnetic resonance imaging are combined with subjective, individual self-reports. PMID:19929909

  9. 'Beautiful' unconventional synthesis and processing technologies of superconductors and some other materials

    NASA Astrophysics Data System (ADS)

    Badica, Petre; Crisan, Adrian; Aldica, Gheorghe; Endo, Kazuhiro; Borodianska, Hanna; Togano, Kazumasa; Awaji, Satoshi; Watanabe, Kazuo; Sakka, Yoshio; Vasylkiv, Oleg

    2011-02-01

    Superconducting materials have contributed significantly to the development of modern materials science and engineering. Specific technological solutions for their synthesis and processing helped in understanding the principles and approaches to the design, fabrication and application of many other materials. In this review, we explore the bidirectional relationship between the general and particular synthesis concepts. The analysis is mostly based on our studies where some unconventional technologies were applied to different superconductors and some other materials. These technologies include spray-frozen freeze-drying, fast pyrolysis, field-assisted sintering (or spark plasma sintering), nanoblasting, processing in high magnetic fields, methods of control of supersaturation and migration during film growth, and mechanical treatments of composite wires. The analysis provides future research directions and some key elements to define the concept of 'beautiful' technology in materials science. It also reconfirms the key position and importance of superconductors in the development of new materials and unconventional synthesis approaches.

  10. Charm and beauty quark masses in the MMHT2014 global PDF analysis

    NASA Astrophysics Data System (ADS)

    Harland-Lang, L. A.; Martin, A. D.; Motylinski, P.; Thorne, R. S.

    2016-01-01

    We investigate the variation in the MMHT2014 PDFs when we allow the heavy-quark masses m_c and m_b to vary away from their default values. We make PDF sets available in steps of Δ m_c =0.05 GeV and Δ m_b =0.25 GeV, and present the variation in the PDFs and in the predictions. We examine the comparison to the HERA data on charm and beauty structure functions and note that in each case the heavy-quark data, and the inclusive data, have a slight preference for lower masses than our default values. We provide PDF sets with three and four active quark flavours, as well as the standard value of five flavours. We use the pole mass definition of the quark masses, as in the default MMHT2014 analysis, but briefly comment on the overline{MS} definition.

  11. The complete mitochondrial genome of beautiful stone loach Traccatichthys pulcher (Nichols & Pope) (Cypriniformes: Balitoridae).

    PubMed

    Chen, I-Shiung; Wen, Zong-Han; Shen, Chia-Ning

    2015-01-01

    In this study, the complete mitogenome sequence of balitorid fish, beautiful stone loach Traccatichthys pulcher (Nichols & Pope, 1927), collected from Hainan island, China, has been sequenced by the long polymerase chain reaction method. The mitogenome, consisting of 16,580 base pairs (bp), had typical vertebrate mitochondrial gene arrangement, including 13 protein coding genes, 22 transfer RNAs, 2 ribosomal RNA genes and a noncoding control region (CR). CR of 928 bp length is located between tRNAPro and tRNAPhe. The overall base composition of T. pulcher is 31.3% for A, 26.8% for C, 25.9% for T and 16.0% for G, with a slight AT bias of 57.3%. The complete mitochondrial genome may provide rather informative data for reconstructing and addressing new molecular perspectives for balitorid phylogenies. PMID:24409869

  12. Internalizing the impossible: anorexic outpatients' experiences with women's beauty and fashion magazines.

    PubMed

    Thomsen, S R; McCoy, J K; Williams, M

    2001-01-01

    A growing body of research has linked the readership of women's beauty and fashion magazines with the development and perpetuation of anorexic behaviors in some young women. Although we know the link exists, little is known about the actual cognitive processes and the ways in which at risk women "use" these magazines to internalize the impossible thin ideal that appears to drive the illness. To understand this phenomenon and the process of internalization in greater depth, the authors conducted qualitative, semi-structured interviews with 28 outpatients at an eating disorder treatment facility in the western United States. Using a grounded theory approach, the authors' analysis provides a detailed description drawn from the patients' personal accounts of how the magazines have influenced their lives and eating-disordered behaviors. PMID:16864373

  13. The making of a modern female body: beauty, health and fitness in interwar Britain.

    PubMed

    Zweiniger-Bargielowska, Ina

    2011-01-01

    In interwar Britain female athleticism, keep-fit classes and physical culture were celebrated as emblems of modernity, and women who cultivated their bodies in the pursuit of beauty, health and fitness represented civic virtue. This article argues that a modern, actively managed female body was part of women's liberation during this period. A modern female body required sex reform and birth control. Fitness culture was circumscribed by traditional notions of femininity. Women's competitive sport remained controversial and slimming in pursuit of fashion was widely condemned. Women from across the social spectrum embraced sport and joined fitness organizations. The rise of a modern female body contributed towards greater equality between the sexes. However, the gender order did not change fundamentally and the ideal woman of the interwar years was represented as a modern, emancipated race mother. PMID:21751481

  14. Beauty and the brain: culture, history and individual differences in aesthetic appreciation

    PubMed Central

    Jacobsen, Thomas

    2010-01-01

    Human aesthetic processing entails the sensation-based evaluation of an entity with respect to concepts like beauty, harmony or well-formedness. Aesthetic appreciation has many determinants ranging from evolutionary, anatomical or physiological constraints to influences of culture, history and individual differences. There are a vast number of dynamically configured neural networks underlying these multifaceted processes of aesthetic appreciation. In the current challenge of successfully bridging art and science, aesthetics and neuroanatomy, the neuro-cognitive psychology of aesthetics can approach this complex topic using a framework that postulates several perspectives, which are not mutually exclusive. In this empirical approach, objective physiological data from event-related brain potentials and functional magnetic resonance imaging are combined with subjective, individual self-reports. PMID:19929909

  15. Cosmetics alter biologically-based factors of beauty: evidence from facial contrast.

    PubMed

    Jones, Alex L; Russell, Richard; Ward, Robert

    2015-01-01

    The use of cosmetics by women seems to consistently increase their attractiveness. What factors of attractiveness do cosmetics alter to achieve this? Facial contrast is a known cue to sexual dimorphism and youth, and cosmetics exaggerate sexual dimorphisms in facial contrast. Here, we demonstrate that the luminance contrast pattern of the eyes and eyebrows is consistently sexually dimorphic across a large sample of faces, with females possessing lower brow contrasts than males, and greater eye contrast than males. Red-green and yellow-blue color contrasts were not found to differ consistently between the sexes. We also show that women use cosmetics not only to exaggerate sexual dimorphisms of brow and eye contrasts, but also to increase contrasts that decline with age. These findings refine the notion of facial contrast, and demonstrate how cosmetics can increase attractiveness by manipulating factors of beauty associated with facial contrast. PMID:25725411

  16. Sleeping Beauty-mediated knockdown of sheep myostatin by RNA interference.

    PubMed

    Hu, Shengwei; Ni, Wei; Sai, Wujiafu; Zhang, Hui; Cao, Xudong; Qiao, Jun; Sheng, Jinliang; Guo, Fei; Chen, Chuangfu

    2011-10-01

    Myostatin is a negative regulator of skeletal muscle growth. Myostatin dysfunction therefore offers a strategy for promoting animal muscle growth in livestock production. Knockdown of myostatin was achieved by combining RNA interference and the Sleeping Beauty (SB) transposon system in sheep cells. Four targeting sites of sheep myostatin were designed and measured for myostatin silencing in sheep fetal fibroblasts by real-time PCR. The sh3 construct induced significant decrease of myostatin gene expression by 90% (P<0.05). Myostatin silencing induced by SB-mediated sh3 was further tested in stably transfected cells. SB transposition increased the integration frequency of genes into sheep genomes and mediated a more efficient myostatin knockdown than random integration of sh3. We suggest that SB-mediated shRNA provides a novel potential tool for gene knockdown in the donor cells of animal cloning. PMID:21698446

  17. Effects of the "beauty is good" stereotype on children's information processing.

    PubMed

    Ramsey, Jennifer L; Langlois, Judith H

    2002-03-01

    The authors tested schematic information processing as a function of attractiveness stereotyping in two studies. An adult experimenter read children (ages 3 to 7 years) eight different stories in which a child narrator encountered two characters who varied in level of attractiveness and displayed positive or negative traits that were either consistent or inconsistent with the "beauty is good" stereotype. Following the story, the experimenter showed each child a photograph of the two characters' faces and asked the child to point to the character who displayed the positive trait. In Experiment 1, children made more errors in identifying female characters with stereotype inconsistent traits but did just the opposite with male characters. Experiment 2 replicated the findings with female characters but found no difference in errors with male characters. The findings have implications for how attractiveness and gender stereotypes affect children's information processing, how attractiveness schemata may be organized, and why physical attractiveness stereotypes are maintained. PMID:11884093

  18. General Relativity: The most beautiful of theories. Applications and trends after 100 years

    NASA Astrophysics Data System (ADS)

    Rovelli, Carlo

    2015-02-01

    Generalising Newton's law of gravitation, general relativity is one of the pillars of modern physics. While applications in the beginning were restricted to isolated effects such as a proper understanding of Mercury's orbit, the second half of the twentieth century saw a massive development of applications. These include cosmology, gravitational waves, and even very practical results for satellite based positioning systems as well as different approaches to unite general relativity with another very successful branch of physics - quantum theory. On the occassion of general relativity's centennial, leading scientists in the different branches of gravitational research review the history and recent advances in the main fields of applications of the theory, which was referred to by Lev Landau as "the most beautiful of the existing physical theories".

  19. Sleeping Beauty transposase structure allows rational design of hyperactive variants for genetic engineering.

    PubMed

    Voigt, Franka; Wiedemann, Lisa; Zuliani, Cecilia; Querques, Irma; Sebe, Attila; Mátés, Lajos; Izsvák, Zsuzsanna; Ivics, Zoltán; Barabas, Orsolya

    2016-01-01

    Sleeping Beauty (SB) is a prominent Tc1/mariner superfamily DNA transposon that provides a popular genome engineering tool in a broad range of organisms. It is mobilized by a transposase enzyme that catalyses DNA cleavage and integration at short specific sequences at the transposon ends. To facilitate SB's applications, here we determine the crystal structure of the transposase catalytic domain and use it to model the SB transposase/transposon end/target DNA complex. Together with biochemical and cell-based transposition assays, our structure reveals mechanistic insights into SB transposition and rationalizes previous hyperactive transposase mutations. Moreover, our data enables us to design two additional hyperactive transposase variants. Our work provides a useful resource and proof-of-concept for structure-based engineering of tailored SB transposases. PMID:27025571

  20. Sleeping Beauty transposase structure allows rational design of hyperactive variants for genetic engineering

    PubMed Central

    Voigt, Franka; Wiedemann, Lisa; Zuliani, Cecilia; Querques, Irma; Sebe, Attila; Mátés, Lajos; Izsvák, Zsuzsanna; Ivics, Zoltán; Barabas, Orsolya

    2016-01-01

    Sleeping Beauty (SB) is a prominent Tc1/mariner superfamily DNA transposon that provides a popular genome engineering tool in a broad range of organisms. It is mobilized by a transposase enzyme that catalyses DNA cleavage and integration at short specific sequences at the transposon ends. To facilitate SB's applications, here we determine the crystal structure of the transposase catalytic domain and use it to model the SB transposase/transposon end/target DNA complex. Together with biochemical and cell-based transposition assays, our structure reveals mechanistic insights into SB transposition and rationalizes previous hyperactive transposase mutations. Moreover, our data enables us to design two additional hyperactive transposase variants. Our work provides a useful resource and proof-of-concept for structure-based engineering of tailored SB transposases. PMID:27025571

  1. Mouse Models of Cancer: Sleeping Beauty Transposons for Insertional Mutagenesis Screens and Reverse Genetic Studies

    PubMed Central

    Tschida, Barbara R.; Largaespada, David A.; Keng, Vincent W.

    2014-01-01

    The genetic complexity and heterogeneity of cancer has posed a problem in designing rationally targeted therapies effective in a large proportion of human cancer. Genomic characterization of many cancer types has provided a staggering amount of data that needs to be interpreted to further our understanding of this disease. Forward genetic screening in mice using Sleeping Beauty (SB) based insertional mutagenesis is an effective method for candidate cancer gene discovery that can aid in distinguishing driver from passenger mutations in human cancer. This system has been adapted for unbiased screens to identify drivers of multiple cancer types. These screens have already identified hundreds of candidate cancer-promoting mutations. These can be used to develop new mouse models for further study, which may prove useful for therapeutic testing. SB technology may also hold the key for rapid generation of reverse genetic mouse models of cancer, and has already been used to model glioblastoma and liver cancer. PMID:24468652

  2. Preferential delivery of the Sleeping Beauty transposon system to livers of mice by hydrodynamic injection

    PubMed Central

    Bell, Jason B; Podetz-Pedersen, Kelly M; Aronovich, Elena L; Belur, Lalitha R; McIvor, R Scott; Hackett, Perry B

    2008-01-01

    Nonviral, DNA-mediated gene transfer is an alternative to viral delivery systems for expressing new genes in cells and tissues. The Sleeping Beauty (SB) transposon system combines the advantages of viruses and naked DNA molecules for gene therapy purposes; however, efficacious delivery of DNA molecules to animal tissues can still be problematic. Here we describe the hydrodynamic delivery procedure for the SB transposon system that allows efficient delivery to the liver in the mouse. The procedure involves rapid, high-pressure injection of a DNA solution into the tail vein. The overall procedure takes <1 h although the delivery into one mouse requires only a few seconds. Successful injections result in expression of the transgene in 5−40% of hepatocytes 1 d after injection. Several weeks after injection, transgene expression stabilizes at ∼1% of the level at 24 h, presumably owing to integration of the transposons into chromosomes. PMID:18079715

  3. [Research in elementary particles and interactions]. Technical progress report

    SciTech Connect

    Adair, R.; Sandweiss, J.; Schmidt, M.

    1992-05-01

    Research of the Yale University groups in the areas of elementary particles and their interactions are outlined. Work on the following topics is reported: development of CDF trigger system; SSC detector development; study of heavy flavors at TPL; search for composite objects produced in relativistic heavy-ion collisions; high-energy polarized lepton-nucleon scattering; rare K{sup +} decays; unpolarized high-energy muon scattering; muon anomalous magnetic moment; theoretical high-energy physics including gauge theories, symmetry breaking, string theory, and gravitation theory; study of e{sup +}e{sup {minus}} interactions with the SLD detector at SLAC; and the production and decay of particles containing charm and beauty quarks.

  4. Subliminal presentation of emotionally negative vs positive primes increases the perceived beauty of target stimuli.

    PubMed

    Era, Vanessa; Candidi, Matteo; Aglioti, Salvatore Maria

    2015-11-01

    Emotions have a profound influence on aesthetic experiences. Studies using affective priming procedures demonstrate, for example, that inducing a conscious negative emotional state biases the perception of abstract stimuli towards the sublime (Eskine et al. Emotion 12:1071-1074, 2012. doi: 10.1037/a0027200). Moreover, subliminal happy facial expressions have a positive impact on the aesthetic evaluation of abstract art (Flexas et al. PLoS ONE 8:e80154, 2013). Little is known about how emotion influences aesthetic perception of non-abstract, representational stimuli, especially those that are particularly relevant for social behaviour, like human bodies. Here, we explore whether the subliminal presentation of emotionally charged visual primes modulates the explicit subjective aesthetic judgment of body images. Using a forward/backward masking procedure, we presented subliminally positive and negative, arousal-matched, emotional or neutral primes and measured their effect on the explicit evaluation of perceived beauty (high vs low) and emotion (positive vs negative) evoked by abstract and body images. We found that negative primes increased subjective aesthetic evaluations of target bodies or abstract images in comparison with positive primes. No influence of primes on the emotional dimension of the targets was found, thus ruling out an unspecific arousal effect and strengthening the link between emotional valence and aesthetic appreciation. More specifically, that subliminal negative primes increase beauty ratings compared to subliminal positive primes indicates a clear link between negative emotions and positive aesthetic evaluations and vice versa, suggesting a possible link between negative emotion and the experience of sublime in art. The study expands previous research by showing the effect of subliminal negative emotions on the subjective aesthetic evaluation not only of abstract but also of body images. PMID:26238406

  5. Beauty, charm, and F{sub L} at HERA: New data vs. Early predictions

    SciTech Connect

    Nikolaev, N. N.; Zoller, V. R.

    2010-04-15

    One of the well-known effects of the asymptotic freedom is splitting of the leading-log BFKL pomeron into a series of isolated poles in complex angular momentum plane. Following our earlier works we explore the phenomenological consequences of the emerging BFKL-Regge factorized expansion for the small-x charm (F{sub 2}{sup c}) and beauty (F{sub 2}{sup b}) structure functions of the proton. As we found earlier, the colordipole approach to the BFKL dynamics predicts uniquely decoupling of subleading hard BFKL exchanges from F{sub 2}{sup c} at moderately large Q{sup 2}. We predicted precocious BFKL asymptotics of F{sub 2}{sup c} (x,Q{sup 2}) with intercept of the rightmost BFKL pole {alpha}{sub P}(0) - 1 = {Delta}{sub P} {approx} 0.4. High-energy open beauty photo- and electroproduction probes the vacuum exchange at much smaller distances and detects significant corrections to the BFKL asymptotics coming from the subleading vacuum poles. In view of the accumulation of the experimental data on small -xF{sub 2}{sup c} and F{sub 2}{sup b} we extended our early predictions to the kinematical domain covered by new HERA measurements. Our structure functions obtained in 1999 agree well with the determination of both F{sub 2}{sup c} and F{sub 2}{sup b} by the H1 published in 2006 but contradict very recent (2008, preliminary)H1 results on F{sub 2}{sup b}. We present also comparison of our early predictions for the longitudinal structure function F{sub L} with recent H1 data (2008) taken at very low Bjorken x. We comment on the electromagnetic corrections to the Okun-Pomeranchuk theorem.

  6. Sleeping Beauty transposon-based system for rapid generation of HBV-replicating stable cell lines.

    PubMed

    Wu, Yong; Zhang, Tian-Ying; Fang, Lin-Lin; Chen, Zi-Xuan; Song, Liu-Wei; Cao, Jia-Li; Yang, Lin; Yuan, Quan; Xia, Ning-Shao

    2016-08-01

    The stable HBV-replicating cell lines, which carry replication-competent HBV genome stably integrated into the genome of host cell, are widely used to evaluate the effects of antiviral agents. However, current methods to generate HBV-replicating cell lines, which are mostly dependent on random integration of foreign DNA via plasmid transfection, are less-efficient and time-consuming. To address this issue, we constructed an all-in-one Sleeping Beauty transposon system (denoted pTSMP-HBV vector) for robust generation of stable cell lines carrying replication-competent HBV genome of different genotype. This vector contains a Sleeping Beauty transposon containing HBV 1.3-copy genome with an expression cassette of the SV40 promoter driving red fluorescent protein (mCherry) and self-cleaving P2A peptide linked puromycin resistance gene (PuroR). In addition, a PGK promoter-driven SB100X hyperactive transposase cassette is placed in the outside of the transposon in the same plasmid.The HBV-replicating stable cells could be obtained from pTSMP-HBV transfected HepG2 cells by red fluorescence-activated cell sorting and puromycin resistant cell selection within 4-week. Using this system, we successfully constructed four cell lines carrying replication-competent HBV genome of genotypes A-D. The replication and viral protein expression profiles of these cells were systematically characterized. In conclusion, our study provides a high-efficiency strategy to generate HBV-replicating stable cell lines, which may facilitate HBV-related virological study. PMID:27091097

  7. Particle acceleration

    NASA Technical Reports Server (NTRS)

    Vlahos, L.; Machado, M. E.; Ramaty, R.; Murphy, R. J.; Alissandrakis, C.; Bai, T.; Batchelor, D.; Benz, A. O.; Chupp, E.; Ellison, D.

    1986-01-01

    Data is compiled from Solar Maximum Mission and Hinothori satellites, particle detectors in several satellites, ground based instruments, and balloon flights in order to answer fundamental questions relating to: (1) the requirements for the coronal magnetic field structure in the vicinity of the energization source; (2) the height (above the photosphere) of the energization source; (3) the time of energization; (4) transistion between coronal heating and flares; (5) evidence for purely thermal, purely nonthermal and hybrid type flares; (6) the time characteristics of the energization source; (7) whether every flare accelerates protons; (8) the location of the interaction site of the ions and relativistic electrons; (9) the energy spectra for ions and relativistic electrons; (10) the relationship between particles at the Sun and interplanetary space; (11) evidence for more than one acceleration mechanism; (12) whether there is single mechanism that will accelerate particles to all energies and also heat the plasma; and (13) how fast the existing mechanisms accelerate electrons up to several MeV and ions to 1 GeV.

  8. Reprogramming of Human Fibroblasts to Induced Pluripotent Stem Cells with Sleeping Beauty Transposon-Based Stable Gene Delivery.

    PubMed

    Sebe, Attila; Ivics, Zoltán

    2016-01-01

    Human induced pluripotent stem (iPS) cells are a source of patient-specific pluripotent stem cells and resemble human embryonic stem (ES) cells in gene expression profiles, morphology, pluripotency, and in vitro differentiation potential. iPS cells are applied in disease modeling, drug screenings, toxicology screenings, and autologous cell therapy. In this protocol, we describe how to derive human iPS cells from fibroblasts by Sleeping Beauty (SB) transposon-mediated gene transfer of reprogramming factors. First, the components of the non-viral Sleeping Beauty transposon system, namely a transposon vector encoding reprogramming transcription factors and a helper plasmid expressing the SB transposase, are electroporated into human fibroblasts. The reprogramming cassette undergoes transposition from the transfected plasmids into the fibroblast genome, thereby resulting in stable delivery of the reprogramming factors. Reprogramming by using this protocol takes ~4 weeks, after which the iPS cells are isolated and clonally propagated. PMID:26895068

  9. Investigating incidence of bacterial and fungal contamination in shared cosmetic kits available in the women beauty salons

    PubMed Central

    Dadashi, Leila; Dehghanzadeh, Reza

    2016-01-01

    Background: Rich texture of cosmetics can provide a suitable medium for growth of pathogenic microorganisms. In addition, skin microflora of anyone is unique which might be harmful to another person. Skin and eye pathogenicity could be communicated by sharing cosmetics in beauty saloons. The main objective of this study was to evaluate microbial contamination of in-use skin and eye cosmetics which are available as public make-up kits for women in the beauty salons. Methods: Fifty-two in-use skin and eye cosmetics were included in this cross sectional study.The specimens from all the cosmetics were collected following the owner’s informed consent, and then about 1 g of the cosmetics was added to nine ml of liquid Eugon LT100 broth medium,two for each product. Ten beauty salons randomly selected from different regions of Tabriz city between June and August 2016. Cosmetics were sampled and carried to the laboratory in sterile condition and then examined to determine bacterial and fungal species in the samples. Results: All of in-use cosmetic were contaminated with bacteria (95% CI = 93.1%-100.0%) and about 19.2% by fungus and yeast (95% CI = 10.8%-31.9%). Streptococcus spp., Pseudomonas spp., Acinetobacter, Bacillus spp., Staphylococcus spp., Escherichia coli, Salmonella, Klebsiella,Citrobacter, Rhodotorula and Candida were dominant species which were isolated from the cosmetics. Powders with 38.5% (95% CI = 17.7%-64.5%) and eyeliners with 30.0% (95%CI = 6.7%-65.2%) were the most fungal contaminated products. Conclusion: Shared cosmetics in beauty salons are almost contaminated by bacteria and fungus.Therefore, it is suggested to avoid sharing cosmetics by women and prevent use of public cosmetics in toilet saloons. PMID:27579260

  10. Particle Physics

    NASA Astrophysics Data System (ADS)

    Cooper, Necia Grant; West, Geoffrey B.

    1988-06-01

    Preface; Introduction; Part I. Theoretical Framework: 1. Scale and dimension - From animals to quarks Geoffrey B. West; 2. Particle physics and the standard model Stuart Raby, Richard C. Slansky and Geoffrey B. West; QCD on a Cray: the masses of elementary particles Gerald Guralnik, Tony Warnock and Charles Zemach; Lecture Notes - From simple field theories to the standard model; 3. Toward a unified theory: an essay on the role of supergravity in the search for unification Richard C. Slansky; 4. Supersymmetry at 100 GeV Stuart Raby; 5. The family problem T. Goldman and Michael Martin Nieto; Part II. Experimental Developments: 6. Experiments to test unification schemes Gary H. Sanders; 7. The march toward higher energies S. Peter Rosen; LAMPF II and the High-Intensity Frontier Henry A. Thiessen; The SSC - An engineering challenge Mahlon T. Wilson; 8. Science underground - the search for rare events L. M. Simmons, Jr; Part III. Personal Perspectives: 9. Quarks and quirks among friends Peter A. Carruthers, Stuart Raby, Richard C. Slansky, Geoffrey B. West and George Zweig; Index.

  11. Readiness to accept Western standard of beauty and body satisfaction among Muslim girls with and without hijab.

    PubMed

    Đurović, Dušanka; Tiosavljević, Marija; Šabanović, Harisa

    2016-10-01

    The purpose of this paper was to determine whether there is a difference in the readiness to accept Western standards of beauty in which thinness is an ideal of beauty and attractiveness, as well in body and appearance satisfaction between Muslim adolescent girls attending madrassa and dressing in accordance with tradition, that is to say wearing hijab, and Muslim adolescent girls who do not wear hijab and who follow contemporary Western-influenced fashion trends. Both of these groups were also compared to a non-Muslim group of adolescent girls. The sample consisted of 75 Muslim adolescent girls with hijab, 75 Muslim adolescent girls without hijab and 75 Orthodox adolescent girls. The following instruments were used: the Eating Attitudes Test (EAT-26), the Sociocultural Attitudes towards Appearance Questionnaire (SATAQ-3) and the Contour Drawing Rating Scale (CDRS). The highest level of body satisfaction (despite this group having the highest body weight in the sample) was evident among Muslim adolescent girls attending madrassa and wearing hijab. They also showed significantly less pressure to attain the Western thin-ideal standards of beauty than adolescent girls who accept Western way of dressing. Research results indicate a significant role of socio-cultural factors in one's attitude towards the body image, but also opens the question of the role of religion as a protective factor when it comes to the body and appearance attitude among Muslim women who wear hijab. PMID:27477544

  12. Study of Charm and Beauty using electron-D{sup 0} azimuthal correlations in the STAR experiment at RHIC

    SciTech Connect

    Kabana, Sonia

    2011-05-23

    The energy loss of heavy quarks in the hot and dense matter created in high-energy nuclear collisions at RHIC, can be used to probe the properties of the medium. Both charm and beauty quarks contribute to the non-photonic electrons through their semi-leptonic decays. It is essential to determine experimentally the relative contributions of charm and beauty quarks to understand the observed suppression of non-photonic electrons at high p{sub T} in central Au+Au collisions. The azimuthal angular correlations of non-photonic electrons with hadrons as well as with the reconstructed D{sup 0} allow to disentangle the contributions of charm and beauty to the electron spectrum. We discuss the STAR measurement of non-photonic electron-D{sup 0} and non-photonic electron-hadron azimuthal correlations in p+p collisions at 200 GeV and explore the consequences for the heavy flavour suppression in heavy ion collisions at RHIC.

  13. Beauty production in pp collisions at √{ s} = 2.76 TeV measured via semi-electronic decays

    NASA Astrophysics Data System (ADS)

    Abelev, B.; Adam, J.; Adamová, D.; Aggarwal, M. M.; Aglieri Rinella, G.; Agnello, M.; Agostinelli, A.; Agrawal, N.; Ahammed, Z.; Ahmad, N.; Ahmed, I.; Ahn, S. U.; Ahn, S. A.; Aimo, I.; Aiola, S.; Ajaz, M.; Akindinov, A.; Alam, S. N.; Aleksandrov, D.; Alessandro, B.; Alexandre, D.; Alici, A.; Alkin, A.; Alme, J.; Alt, T.; Altinpinar, S.; Altsybeev, I.; Alves Garcia Prado, C.; Andrei, C.; Andronic, A.; Anguelov, V.; Anielski, J.; Antičić, T.; Antinori, F.; Antonioli, P.; Aphecetche, L.; Appelshäuser, H.; Arcelli, S.; Armesto, N.; Arnaldi, R.; Aronsson, T.; Arsene, I. C.; Arslandok, M.; Augustinus, A.; Averbeck, R.; Awes, T. C.; Azmi, M. D.; Bach, M.; Badalà, A.; Baek, Y. W.; Bagnasco, S.; Bailhache, R.; Bala, R.; Baldisseri, A.; Baltasar Dos Santos Pedrosa, F.; Baral, R. C.; Barbera, R.; Barile, F.; Barnaföldi, G. G.; Barnby, L. S.; Barret, V.; Bartke, J.; Basile, M.; Bastid, N.; Basu, S.; Bathen, B.; Batigne, G.; Batista Camejo, A.; Batyunya, B.; Batzing, P. C.; Baumann, C.; Bearden, I. G.; Beck, H.; Bedda, C.; Behera, N. K.; Belikov, I.; Bellini, F.; Bellwied, R.; Belmont-Moreno, E.; Belmont, R.; Belyaev, V.; Bencedi, G.; Beole, S.; Berceanu, I.; Bercuci, A.; Berdnikov, Y.; Berenyi, D.; Berger, M. E.; Bertens, R. A.; Berzano, D.; Betev, L.; Bhasin, A.; Bhat, I. R.; Bhati, A. K.; Bhattacharjee, B.; Bhom, J.; Bianchi, L.; Bianchi, N.; Bianchin, C.; Bielčík, J.; Bielčíková, J.; Bilandzic, A.; Bjelogrlic, S.; Blanco, F.; Blau, D.; Blume, C.; Bock, F.; Bogdanov, A.; Bøggild, H.; Bogolyubsky, M.; Böhmer, F. V.; Boldizsár, L.; Bombara, M.; Book, J.; Borel, H.; Borissov, A.; Bossú, F.; Botje, M.; Botta, E.; Böttger, S.; Braun-Munzinger, P.; Bregant, M.; Breitner, T.; Broker, T. A.; Browning, T. A.; Broz, M.; Bruna, E.; Bruno, G. E.; Budnikov, D.; Buesching, H.; Bufalino, S.; Buncic, P.; Busch, O.; Buthelezi, Z.; Caffarri, D.; Cai, X.; Caines, H.; Calero Diaz, L.; Caliva, A.; Calvo Villar, E.; Camerini, P.; Carena, F.; Carena, W.; Castillo Castellanos, J.; Casula, E. A. R.; Catanescu, V.; Cavicchioli, C.; Ceballos Sanchez, C.; Cepila, J.; Cerello, P.; Chang, B.; Chapeland, S.; Charvet, J. L.; Chattopadhyay, S.; Chattopadhyay, S.; Chelnokov, V.; Cherney, M.; Cheshkov, C.; Cheynis, B.; Chibante Barroso, V.; Chinellato, D. D.; Chochula, P.; Chojnacki, M.; Choudhury, S.; Christakoglou, P.; Christensen, C. H.; Christiansen, P.; Chujo, T.; Chung, S. U.; Cicalo, C.; Cifarelli, L.; Cindolo, F.; Cleymans, J.; Colamaria, F.; Colella, D.; Collu, A.; Colocci, M.; Conesa Balbastre, G.; Conesa del Valle, Z.; Connors, M. E.; Contreras, J. G.; Cormier, T. M.; Corrales Morales, Y.; Cortese, P.; Cortés Maldonado, I.; Cosentino, M. R.; Costa, F.; Crochet, P.; Cruz Albino, R.; Cuautle, E.; Cunqueiro, L.; Dainese, A.; Dang, R.; Danu, A.; Das, D.; Das, I.; Das, K.; Das, S.; Dash, A.; Dash, S.; De, S.; Delagrange, H.; Deloff, A.; Dénes, E.; D'Erasmo, G.; De Caro, A.; de Cataldo, G.; de Cuveland, J.; De Falco, A.; De Gruttola, D.; De Marco, N.; De Pasquale, S.; de Rooij, R.; Diaz Corchero, M. A.; Dietel, T.; Dillenseger, P.; Divià, R.; Di Bari, D.; Di Liberto, S.; Di Mauro, A.; Di Nezza, P.; Djuvsland, Ø.; Dobrin, A.; Dobrowolski, T.; Domenicis Gimenez, D.; Dönigus, B.; Dordic, O.; Dørheim, S.; Dubey, A. K.; Dubla, A.; Ducroux, L.; Dupieux, P.; Dutta Majumdar, A. K.; Hilden, T. E.; Ehlers, R. J.; Elia, D.; Engel, H.; Erazmus, B.; Erdal, H. A.; Eschweiler, D.; Espagnon, B.; Esposito, M.; Estienne, M.; Esumi, S.; Evans, D.; Evdokimov, S.; Fabris, D.; Faivre, J.; Falchieri, D.; Fantoni, A.; Fasel, M.; Fehlker, D.; Feldkamp, L.; Felea, D.; Feliciello, A.; Feofilov, G.; Ferencei, J.; Fernández Téllez, A.; Ferreiro, E. G.; Ferretti, A.; Festanti, A.; Figiel, J.; Figueredo, M. A. S.; Filchagin, S.; Finogeev, D.; Fionda, F. M.; Fiore, E. M.; Floratos, E.; Floris, M.; Foertsch, S.; Foka, P.; Fokin, S.; Fragiacomo, E.; Francescon, A.; Frankenfeld, U.; Fuchs, U.; Furget, C.; Fusco Girard, M.; Gaardhøje, J. J.; Gagliardi, M.; Gago, A. M.; Gallio, M.; Gangadharan, D. R.; Ganoti, P.; Gao, C.; Garabatos, C.; Garcia-Solis, E.; Gargiulo, C.; Garishvili, I.; Gerhard, J.; Germain, M.; Gheata, A.; Gheata, M.; Ghidini, B.; Ghosh, P.; Ghosh, S. K.; Gianotti, P.; Giubellino, P.; Gladysz-Dziadus, E.; Glässel, P.; Gomez Ramirez, A.; González-Zamora, P.; Gorbunov, S.; Görlich, L.; Gotovac, S.; Graczykowski, L. K.; Grelli, A.; Grigoras, A.; Grigoras, C.; Grigoriev, V.; Grigoryan, A.; Grigoryan, S.; Grinyov, B.; Grion, N.; Grosse-Oetringhaus, J. F.; Grossiord, J.-Y.; Grosso, R.; Guber, F.; Guernane, R.; Guerzoni, B.; Guilbaud, M.; Gulbrandsen, K.; Gulkanyan, H.; Gumbo, M.; Gunji, T.; Gupta, A.; Gupta, R.; Khan, K. H.; Haake, R.; Haaland, Ø.; Hadjidakis, C.; Haiduc, M.; Hamagaki, H.; Hamar, G.

    2014-11-01

    The ALICE Collaboration at the LHC reports measurement of the inclusive production cross section of electrons from semi-leptonic decays of beauty hadrons with rapidity | y | < 0.8 and transverse momentum 1 beauty hadrons are suppressed using the impact parameter of the corresponding tracks. The production cross section of beauty decay electrons is compared to the result obtained with an alternative method which uses the distribution of the azimuthal angle between heavy-flavour decay electrons and charged hadrons. Perturbative QCD predictions agree with the measured cross section within the experimental and theoretical uncertainties. The integrated visible cross section, σb→e = 3.47 ± 0.40 (stat)-1.33+1.12 (sys) ± 0.07 (norm) μb, was extrapolated to full phase space using Fixed Order plus Next-to-Leading Log (FONLL) calculations to obtain the total b b bar production cross section, σbbbar = 130 ± 15.1 (stat)-49.8+42.1 (sys)-3.1+3.4 (extr) ± 2.5 (norm) ± 4.4 (BR) μb.

  14. Excision of Sleeping Beauty transposons: parameters and applications to gene therapy

    PubMed Central

    Liu, Geyi; Aronovich, Elena L.; Cui, Zongbin; Whitley, Chester B.; Hackett, Perry B.

    2007-01-01

    A major problem in gene therapy is the determination of the rates at which gene transfer has occurred. Our work has focused on applications of the Sleeping Beauty (SB) transposon system as a non-viral vector for gene therapy. Excision of a transposon from a donor molecule and its integration into a cellular chromosome are catalyzed by SB transposase. In this study, we used a plasmid-based excision assay to study the excision step of transposition. We used the excision assay to evaluate the importance of various sequences that border the sites of excision inside and outside the transposon in order to determine the most active sequences for transposition from a donor plasmid. These findings together with our previous results in transposase binding to the terminal repeats suggest that the sequences in the transposon-junction of SB are involved in steps subsequent to DNA binding but before excision, and that they may have a role in transposase–transposon interaction. We found that SB transposons leave characteristically different footprints at excision sites in different cell types, suggesting that alternative repair machineries operate in concert with transposition. Most importantly, we found that the rates of excision correlate with the rates of transposition. We used this finding to assess transposition in livers of mice that were injected with the SB transposon and transposase. The excision assay appears to be a relatively quick and easy method to optimize protocols for delivery of genes in SB transposons to mammalian chromosomes in living animals. PMID:15133768

  15. Transcriptionally regulated and nontoxic delivery of the hyperactive Sleeping Beauty Transposase.

    PubMed

    Cocchiarella, Fabienne; Latella, Maria Carmela; Basile, Valentina; Miselli, Francesca; Galla, Melanie; Imbriano, Carol; Recchia, Alessandra

    2016-01-01

    The Sleeping Beauty (SB) transposase and, in particular, its hyperactive variant SB100X raises increasing interest for gene therapy application, including genome modification and, more recently, induced pluripotent stem cells (iPS) reprogramming. The documented cytotoxicity of the transposase, when constitutively expressed by an integrating retroviral vector (iRV), has been circumvented by the transient delivery of SB100X using retroviral mRNA transfer. In this study, we developed an alternative, safe, and efficient transposase delivery system based on a tetracycline-ON regulated expression cassette and the rtTA2(S)-M2 transactivator gene transiently delivered by integration-defective lentiviral vectors (IDLVs). Compared with iRV-mediated delivery, expression of tetracycline-induced SB100X delivered by an IDLV results in more efficient integration of a GFP transposon and reduced toxicity. Tightly regulated expression and reactivation of the transposase was achieved in HeLa cells as wells as in human primary keratinocytes. Based on these properties, the regulated transposase-IDLV vectors may represent a valuable tool for genetic engineering and therapeutic gene transfer. PMID:27574698

  16. Generation of trangenic Xenopus laevis using the Sleeping Beauty transposon system.

    PubMed

    Sinzelle, L; Vallin, J; Coen, L; Chesneau, A; Du Pasquier, D; Pollet, N; Demeneix, B; Mazabraud, A

    2006-12-01

    Using the Sleeping Beauty (SB) transposon system, we have developed a simple method for the generation of Xenopus laevis transgenic lines. The transgenesis protocol is based on the co-injection of the SB transposase mRNA and a GFP-reporter transposon into one-cell stage embryos. Transposase-dependent reporter gene expression was observed in cell clones and in hemi-transgenic animals. We determined an optimal ratio of transposase mRNA versus transposon-carrying plasmid DNA that enhanced the proportion of hemi-transgenic tadpoles. The transgene is integrated into the genome and may be transmitted to the F1 offspring depending on the germline mosaicism. Although the transposase is necessary for efficient generation of transgenic Xenopus, the integration of the transgene occurred by an non-canonical transposition process. This was observed for two transgenic lines analysed. The transposon-based technique leads to a high transgenesis rate and is simple to handle. For these reasons, it could present an attractive alternative to the classical Restriction Enzyme Mediated Integration (REMI) procedure. PMID:16957880

  17. Sleeping Beauty transposase modulates cell-cycle progression through interaction with Miz-1

    PubMed Central

    Walisko, Oliver; Izsvák, Zsuzsanna; Szabó, Kornélia; Kaufman, Christopher D.; Herold, Steffi; Ivics, Zoltán

    2006-01-01

    We used the Sleeping Beauty (SB) transposable element as a tool to probe transposon–host cell interactions in vertebrates. The Miz-1 transcription factor was identified as an interactor of the SB transposase in a yeast two-hybrid screen. Through its association with Miz-1, the SB transposase down-regulates cyclin D1 expression in human cells, as evidenced by differential gene expression analysis using microarray hybridization. Down-regulation of cyclin D1 results in a prolonged G1 phase of the cell cycle and retarded growth of transposase-expressing cells. G1 slowdown is associated with a decrease of cyclin D1/cdk4-specific phosphorylation of the retinoblastoma protein. Both cyclin D1 down-regulation and the G1 slowdown induced by the transposase require Miz-1. A temporary G1 arrest enhances transposition, suggesting that SB transposition is favored in the G1 phase of the cell cycle, where the nonhomologous end-joining pathway of DNA repair is preferentially active. Because nonhomologous end-joining is required for efficient SB transposition, the transposase-induced G1 slowdown is probably a selfish act on the transposon’s part to maximize the chance for a successful transposition event. PMID:16537485

  18. Targeting the Central Nervous System with Herpes Simplex Virus / Sleeping Beauty Hybrid Amplicon Vectors

    PubMed Central

    de Silva, Suresh; Bowers, William J.

    2014-01-01

    The pursuits of sustainable treatments for diseases and disorders that afflict the central nervous system (CNS) have proven challenging for the field of viral vector-based gene therapy. However, recent advances in viral vector technology coupled with efficient delivery methods have opened up new avenues that show promise at the preclinical testing stage. The development of the Herpes Simplex Virus/Sleeping Beauty (HSV/SB) hybrid vector represents such an advance for devising treatments targeting the CNS with its potential for stably integrating large transgenomic segments of DNA within the genomes of transduced cells. In utero administration of this hybrid vector into the embryonic mouse brain has revealed the capacity for widespread transgene dissemination due to the targeting of a neuronal precursor cell population. This unique feature has provided the means to stably express a transgene throughout the brain for prolonged periods, which is a prerequisite for the treatment of progressive CNS disorders. In this review we provide a comprehensive breakdown of the characteristics of the HSV/SB vector system and how it can be efficiently employed in the derivation of CNS-targeted gene therapeutic strategies. PMID:21711226

  19. Characterization of Sleeping Beauty Transposition and Its Application to Genetic Screening in Mice

    PubMed Central

    Horie, Kyoji; Yusa, Kosuke; Yae, Kojiro; Odajima, Junko; Fischer, Sylvia E. J.; Keng, Vincent W.; Hayakawa, Tomoko; Mizuno, Sumi; Kondoh, Gen; Ijiri, Takashi; Matsuda, Yoichi; Plasterk, Ronald H. A.; Takeda, Junji

    2003-01-01

    The use of mutant mice plays a pivotal role in determining the function of genes, and the recently reported germ line transposition of the Sleeping Beauty (SB) transposon would provide a novel system to facilitate this approach. In this study, we characterized SB transposition in the mouse germ line and assessed its potential for generating mutant mice. Transposition sites not only were clustered within 3 Mb near the donor site but also were widely distributed outside this cluster, indicating that the SB transposon can be utilized for both region-specific and genome-wide mutagenesis. The complexity of transposition sites in the germ line was high enough for large-scale generation of mutant mice. Based on these initial results, we conducted germ line mutagenesis by using a gene trap scheme, and the use of a green fluorescent protein reporter made it possible to select for mutant mice rapidly and noninvasively. Interestingly, mice with mutations in the same gene, each with a different insertion site, were obtained by local transposition events, demonstrating the feasibility of the SB transposon system for region-specific mutagenesis. Our results indicate that the SB transposon system has unique features that complement other mutagenesis approaches. PMID:14645530

  20. Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma

    PubMed Central

    Mann, Karen M.; Ward, Jerrold M.; Yew, Christopher Chin Kuan; Kovochich, Anne; Dawson, David W.; Black, Michael A.; Brett, Benjamin T.; Sheetz, Todd E.; Dupuy, Adam J.; Chang, David K.; Biankin, Andrew V.; Waddell, Nicola; Kassahn, Karin S.; Grimmond, Sean M.; Rust, Alistair G.; Adams, David J.; Jenkins, Nancy A.; Copeland, Neal G.

    2012-01-01

    Pancreatic cancer is one of the most deadly cancers affecting the Western world. Because the disease is highly metastatic and difficult to diagnosis until late stages, the 5-y survival rate is around 5%. The identification of molecular cancer drivers is critical for furthering our understanding of the disease and development of improved diagnostic tools and therapeutics. We have conducted a mutagenic screen using Sleeping Beauty (SB) in mice to identify new candidate cancer genes in pancreatic cancer. By combining SB with an oncogenic Kras allele, we observed highly metastatic pancreatic adenocarcinomas. Using two independent statistical methods to identify loci commonly mutated by SB in these tumors, we identified 681 loci that comprise 543 candidate cancer genes (CCGs); 75 of these CCGs, including Mll3 and Ptk2, have known mutations in human pancreatic cancer. We identified point mutations in human pancreatic patient samples for another 11 CCGs, including Acvr2a and Map2k4. Importantly, 10% of the CCGs are involved in chromatin remodeling, including Arid4b, Kdm6a, and Nsd3, and all SB tumors have at least one mutated gene involved in this process; 20 CCGs, including Ctnnd1, Fbxo11, and Vgll4, are also significantly associated with poor patient survival. SB mutagenesis provides a rich resource of mutations in potential cancer drivers for cross-comparative analyses with ongoing sequencing efforts in human pancreatic adenocarcinoma. PMID:22421440

  1. A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis

    PubMed Central

    Moriarity, Branden S; Otto, George M; Rahrmann, Eric P; Rathe, Susan K; Wolf, Natalie K; Weg, Madison T; Manlove, Luke A; LaRue, Rebecca S; Temiz, Nuri A; Molyneux, Sam D; Choi, Kwangmin; Holly, Kevin J; Sarver, Aaron L; Scott, Milcah C; Forster, Colleen L; Modiano, Jaime F; Khanna, Chand; Hewitt, Stephen M; Khokha, Rama; Yang, Yi; Gorlick, Richard; Dyer, Michael A; Largaespada, David A

    2016-01-01

    Osteosarcomas are sarcomas of the bone, derived from osteoblasts or their precursors, with a high propensity to metastasize. Osteosarcoma is associated with massive genomic instability, making it problematic to identify driver genes using human tumors or prototypical mouse models, many of which involve loss of Trp53 function. To identify the genes driving osteosarcoma development and metastasis, we performed a Sleeping Beauty (SB) transposon-based forward genetic screen in mice with and without somatic loss of Trp53. Common insertion site (CIS) analysis of 119 primary tumors and 134 metastatic nodules identified 232 sites associated with osteosarcoma development and 43 sites associated with metastasis, respectively. Analysis of CIS-associated genes identified numerous known and new osteosarcoma-associated genes enriched in the ErbB, PI3K-AKT-mTOR and MAPK signaling pathways. Lastly, we identified several oncogenes involved in axon guidance, including Sema4d and Sema6d, which we functionally validated as oncogenes in human osteosarcoma. PMID:25961939

  2. Is it time to awaken Sleeping Beauty? European psychiatry has been sleeping since 1980.

    PubMed

    de Leon, Jose

    2014-01-01

    The Diagnostic and Statistical Manual of Mental Disorders (DSM-III), published in 1980, has led to a dead end, the DSM-V. Following the allegory of Sleeping Beauty, the DSM-III put European psychiatry to sleep; it now must wake up to create a 21st century psychiatric language for descriptive psychopathology and psychiatric nosology. Four topics are reviewed. First, the review of descriptive psychopathology focuses on: a) Chaslin's and Jaspers's books, and b) Schneider's transmittal of Jaspers's ideas and involvement with Kraepelin in incorporating neuroscience into psychiatric nosology. Second, US psychiatry's historic steps include: a) the pseudoscience of psychoanalysis, b) the low level of pre-DSM-III diagnostic expertise, c) the neo-Kraepelinian revolution which led to DSM-III, d) the failure to improve diagnostic skills, and e) the reprise of Kraepelin's marketing ("neuroscience will save psychiatry"). Third, the DSM-III devastated European psychiatry by destroying: a) the national textbooks which increased consistency but eliminated creative European thinking; and b) the Arbeitsgemenschaft fur Methodic und Dokumentation in der Psychiatrie, the most reasonable attempt to reach diagnostic agreement: start with symptoms/signs (first level) rather than disorders (second level). Fourth, Berrios elaborated upon Jaspers, who described psychiatry as a hybrid science and heterogeneous. Berrios affirmed that psychiatric symptoms/signs are hybrid. Some symptoms are in the "semantic space" and cannot be "explained" by neuroscience. PMID:24486358

  3. Sleeping Beauty-mediated somatic mutagenesis implicates CSF1 in the formation of high grade astrocytomas

    PubMed Central

    Bender, Aaron M.; Collier, Lara S.; Rodriguez, Fausto J.; Tieu, Christina; Larson, Jon D.; Halder, Chandralekha; Mahlum, Eric; Kollmeyer, Thomas M.; Akagi, Keiko; Sarkar, Gobinda; Largaespada, David A.; Jenkins, Robert B.

    2010-01-01

    The Sleeping Beauty (SB) transposon system has been used as an insertional mutagenesis tool to identify novel cancer genes. To identify glioma-associated genes, we evaluated tumor formation in brain tissue from 117 transgenic mice that had undergone constitutive SB-mediated transposition. Upon analysis, 21 samples (18%) contained neoplastic tissue with features of high grade astrocytomas. These tumors expressed glial markers and were histologically similar to human glioma. Genomic DNA from SB-induced astrocytoma tissue was extracted and transposon insertion sites were identified. Insertions in the growth factor gene Csf1 were found in 13 of the 21 tumors (62%), clustered in introns 5 and 8. Using RT-PCR, we documented increased Csf1 RNAs in tumor versus adjacent normal tissue, with identification of transposon-terminated Csf1 mRNAs in astrocytomas with SB insertions in intron 8. Analysis of human glioblastomas revealed increased levels of Csf1 RNA and protein. Together, these results indicate that SB-insertional mutagenesis can identify high-grade astrocytoma-associated genes, and they imply an important role for CSF1 in the development of these tumors. PMID:20388773

  4. Decision making in Germany: is health economic evaluation as a supporting tool a sleeping beauty?

    PubMed

    Gerber-Grote, Andreas; Sandmann, Frank Gerd; Zhou, Min; Ten Thoren, Corinna; Schwalm, Anja; Weigel, Carolin; Balg, Christiane; Mensch, Alexander; Mostardt, Sarah; Seidl, Astrid; Lhachimi, Stefan K

    2014-01-01

    For many years, the legal situation within the statutory health insurance (SHI) system in Germany has allowed for health economic evaluations. There are various reasons why health economic evaluations have played virtually no role in decision making until now: to begin with, a method for the evaluation of the relation between benefits and costs which needed to be in accordance with the legal requirements had to be developed, the outcome of which was the efficiency frontier approach. Subsequent health care reforms have led to changing objectives and strategies. Currently, price negotiations of newly launched drugs are based on an early benefit assessment of dossiers submitted by pharmaceutical manufacturers. Other reasons might be the presently very comfortable financial situation of the statutory health insurance system as well as a historically grown societal fear and discomfort towards what is perceived to be a rationing of medicinal products. For the time being, it remains open how long the German health care system can afford to continue neglecting the benefits of health economic evaluations for drug and non-drug interventions, and when it will be time to wake this sleeping beauty. PMID:25444297

  5. Sleeping Beauty mutagenesis in a mouse medulloblastoma model defines networks that discriminate between human molecular subgroups.

    PubMed

    Genovesi, Laura A; Ng, Ching Ging; Davis, Melissa J; Remke, Marc; Taylor, Michael D; Adams, David J; Rust, Alistair G; Ward, Jerrold M; Ban, Kenneth H; Jenkins, Nancy A; Copeland, Neal G; Wainwright, Brandon J

    2013-11-12

    The Sleeping Beauty (SB) transposon mutagenesis screen is a powerful tool to facilitate the discovery of cancer genes that drive tumorigenesis in mouse models. In this study, we sought to identify genes that functionally cooperate with sonic hedgehog signaling to initiate medulloblastoma (MB), a tumor of the cerebellum. By combining SB mutagenesis with Patched1 heterozygous mice (Ptch1(lacZ/+)), we observed an increased frequency of MB and decreased tumor-free survival compared with Ptch1(lacZ/+) controls. From an analysis of 85 tumors, we identified 77 common insertion sites that map to 56 genes potentially driving increased tumorigenesis. The common insertion site genes identified in the mutagenesis screen were mapped to human orthologs, which were used to select probes and corresponding expression data from an independent set of previously described human MB samples, and surprisingly were capable of accurately clustering known molecular subgroups of MB, thereby defining common regulatory networks underlying all forms of MB irrespective of subgroup. We performed a network analysis to discover the likely mechanisms of action of subnetworks and used an in vivo model to confirm a role for a highly ranked candidate gene, Nfia, in promoting MB formation. Our analysis implicates candidate cancer genes in the deregulation of apoptosis and translational elongation, and reveals a strong signature of transcriptional regulation that will have broad impact on expression programs in MB. These networks provide functional insights into the complex biology of human MB and identify potential avenues for intervention common to all clinical subgroups. PMID:24167280

  6. Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma.

    PubMed

    Mann, Karen M; Ward, Jerrold M; Yew, Christopher Chin Kuan; Kovochich, Anne; Dawson, David W; Black, Michael A; Brett, Benjamin T; Sheetz, Todd E; Dupuy, Adam J; Chang, David K; Biankin, Andrew V; Waddell, Nicola; Kassahn, Karin S; Grimmond, Sean M; Rust, Alistair G; Adams, David J; Jenkins, Nancy A; Copeland, Neal G

    2012-04-17

    Pancreatic cancer is one of the most deadly cancers affecting the Western world. Because the disease is highly metastatic and difficult to diagnosis until late stages, the 5-y survival rate is around 5%. The identification of molecular cancer drivers is critical for furthering our understanding of the disease and development of improved diagnostic tools and therapeutics. We have conducted a mutagenic screen using Sleeping Beauty (SB) in mice to identify new candidate cancer genes in pancreatic cancer. By combining SB with an oncogenic Kras allele, we observed highly metastatic pancreatic adenocarcinomas. Using two independent statistical methods to identify loci commonly mutated by SB in these tumors, we identified 681 loci that comprise 543 candidate cancer genes (CCGs); 75 of these CCGs, including Mll3 and Ptk2, have known mutations in human pancreatic cancer. We identified point mutations in human pancreatic patient samples for another 11 CCGs, including Acvr2a and Map2k4. Importantly, 10% of the CCGs are involved in chromatin remodeling, including Arid4b, Kdm6a, and Nsd3, and all SB tumors have at least one mutated gene involved in this process; 20 CCGs, including Ctnnd1, Fbxo11, and Vgll4, are also significantly associated with poor patient survival. SB mutagenesis provides a rich resource of mutations in potential cancer drivers for cross-comparative analyses with ongoing sequencing efforts in human pancreatic adenocarcinoma. PMID:22421440

  7. A Sleeping Beauty screen reveals NF-kB activation in CLL mouse model.

    PubMed

    Zanesi, Nicola; Balatti, Veronica; Riordan, Jesse; Burch, Aaron; Rizzotto, Lara; Palamarchuk, Alexey; Cascione, Luciano; Lagana, Alessandro; Dupuy, Adam J; Croce, Carlo M; Pekarsky, Yuri

    2013-05-23

    TCL1 oncogene is overexpressed in aggressive form of human chronic lymphocytic leukemia (CLL) and its dysregulation in mouse B cells causes a CD5-positive leukemia similar to the aggressive form of human CLLs. To identify oncogenes that cooperate with Tcl1, we performed genetic screen in Eμ-TCL1 mice using Sleeping Beauty transposon-mediated mutagenesis. Analysis of transposon common insertion sites identified 7 genes activated by transposon insertions. Overexpression of these genes in mouse CLL was confirmed by real time reverse transcription-polymerase chain reaction. Interestingly, the main known function of 4 of 7 genes (Nfkb1, Tab2, Map3K14, and Nfkbid) is participation in or activation of the nuclear factor-kB (NF-kB) pathway. In addition, activation of the NF-kB is 1 of main functions of Akt2, also identified in the screen. These findings demonstrate cooperation of Tcl1 and the NF-kB pathway in the pathogenesis of aggressive CLL. Identification cooperating cancer genes will result in the development of combinatorial therapies to treat CLL. PMID:23591791

  8. A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis.

    PubMed

    Moriarity, Branden S; Otto, George M; Rahrmann, Eric P; Rathe, Susan K; Wolf, Natalie K; Weg, Madison T; Manlove, Luke A; LaRue, Rebecca S; Temiz, Nuri A; Molyneux, Sam D; Choi, Kwangmin; Holly, Kevin J; Sarver, Aaron L; Scott, Milcah C; Forster, Colleen L; Modiano, Jaime F; Khanna, Chand; Hewitt, Stephen M; Khokha, Rama; Yang, Yi; Gorlick, Richard; Dyer, Michael A; Largaespada, David A

    2015-06-01

    Osteosarcomas are sarcomas of the bone, derived from osteoblasts or their precursors, with a high propensity to metastasize. Osteosarcoma is associated with massive genomic instability, making it problematic to identify driver genes using human tumors or prototypical mouse models, many of which involve loss of Trp53 function. To identify the genes driving osteosarcoma development and metastasis, we performed a Sleeping Beauty (SB) transposon-based forward genetic screen in mice with and without somatic loss of Trp53. Common insertion site (CIS) analysis of 119 primary tumors and 134 metastatic nodules identified 232 sites associated with osteosarcoma development and 43 sites associated with metastasis, respectively. Analysis of CIS-associated genes identified numerous known and new osteosarcoma-associated genes enriched in the ErbB, PI3K-AKT-mTOR and MAPK signaling pathways. Lastly, we identified several oncogenes involved in axon guidance, including Sema4d and Sema6d, which we functionally validated as oncogenes in human osteosarcoma. PMID:25961939

  9. Electroporation markedly improves Sleeping Beauty transposon-induced tumorigenesis in mice.

    PubMed

    Jung, S; Choi, H-J; Park, H-K; Jo, W; Jang, S; Ryu, J-E; Kim, W-J; Yu, E-S; Son, W-C

    2014-08-01

    The Sleeping Beauty (SB) transposon system is an important tool for genetic studies. It is used to insert a gene of interest into the host chromosome, thus enabling permanent gene expression. However, this system is less useful in higher eukaryotes because the transposition frequency is low. Efforts to improve the efficacy of the SB transposon system have focused on the method of gene delivery, but although electroporation has recently attracted much attention as an in vivo gene delivery tool, the simultaneous use of electroporation and the SB transposon system has not been studied for gene transfer in mice. In this study, electroporation was used in a model of SB transposon-induced insertional tumorigenesis. Electroporation increased the rate of tumor development to three times that of the control group. There was no difference in phenotype between tumors induced with the SB transposon system alone and those induced by the SB transposon and electroporation. Electroporation therefore may be an efficient means of improving the efficacy of gene transfer via the SB transposon system. PMID:24992966

  10. Delivery of small interfering RNA (siRNA) using the sleeping beauty transposon.

    PubMed

    Fletcher, Bradley S

    2010-11-01

    RNA interference (RNAi) is an evolutionarily conserved process that silences gene expression through double-stranded RNA species in a sequence-specific manner. Small interfering RNAs (siRNAs) can promote sequence-specific degradation and/or translational repression of target RNA by activation of the RNA-induced silencing complex (RISC). Traditionally, silencing in mammalian cells had been achieved by transfection of synthetically derived siRNA duplexes, resulting in transient gene suppression of the target sequence. As the technology was advanced, inhibitory short-hairpin-shaped RNAs (shRNAs) could be produced by transcription from RNA polymerase-III (pol-III)-driven promoters, such as H1, U6, or cytomegalovirus (CMV)-enhanced pol III promoters. Following transcription, the shRNAs are processed by the enzyme Dicer into active siRNA. This approach allows for the continuous production of siRNA within cells using a DNA template and offers increased options for delivery of the pol-III-driven transcriptional units. A number of different viral vectors, as well as plasmid DNAs, have been utilized to deliver shRNA to mammalian cells. Here, the Tc1/mariner DNA transposon Sleeping Beauty (SB) is used as a tool to deliver shRNA-encoding transcriptional units. The SB transposon system uses a "cut-and-paste" mechanism to insert the transposon into random TA dinucleotides within the target genome. The shRNAs are then processed and used for gene knockdown. PMID:21041394

  11. Chemical profiling and gene expression profiling during the manufacturing process of Taiwan oolong tea "Oriental Beauty".

    PubMed

    Cho, Jeong-Yong; Mizutani, Masaharu; Shimizu, Bun-ichi; Kinoshita, Tomomi; Ogura, Miharu; Tokoro, Kazuhiko; Lin, Mu-Lien; Sakata, Kanzo

    2007-06-01

    Oriental Beauty, which is made from tea leaves infested by the tea green leafhopper (Jacobiasca formosana) in Taiwan, has a unique aroma like ripe fruits and honey. To determine what occurs in the tea leaves during the oolong tea manufacturing process, the gene expression profiles and the chemical profiles were investigated. Tea samples were prepared from Camellia sinensis var. sinensis cv. Chin-shin Dah-pang while the tea leaves were attacked by the insect. The main volatile compounds, such as linalool-oxides, benzyl alcohol, 2-phenylethanol, and 2,6-dimethylocta-3,7-diene-2,6-diol, increased during manufacture. The gene expression profiles during manufacture were analyzed by differential screening between fresh leaves and tea leaves of the first turn over. Many up-regulated transcripts were found to encode various proteins homologous to stress response proteins. Accordingly, the endogenous contents of abscisic acid and raffinose increased during manufacture. Thus the traditional manufacturing method is a unique process that utilizes plant defense responses to elevate the production of volatile compounds and other metabolites. PMID:17587678

  12. "Focus on glaciers": an exposition of geo-photos to attract interest on a vanishing beauty

    NASA Astrophysics Data System (ADS)

    Rossi, Giuliana; Bohm, Gualtiero; Saraò, Angela

    2016-04-01

    Public awareness of the effects of industrial activity on the environment and climate is growing, but the information needs to be disseminated to a larger number of people, of all ages, to be effective. Images can certainly be an optimal tool to communicate the important message of global warming effects and, thanks to the digital techniques, photography is gaining a new popularity. Anybody, owning just a phone or a tablet, has a camera to catch images that can be immediately spread worldwide via web sites, on-line newspapers, social media or blogs to convey messages and emotions. Fine art photography can surely help in attracting interest and in educating people. For this reason, we organize an exposition of artistic pictures; the beauty of the images attracts the eyes of the public, discovering an unknown reality and gives the opportunity to illustrate the dramatic retreat of the Alpine glaciers, and the majesty of the Antarctic landscape, put in danger by the climate changes. The glaciers are the main characters, with the infinite grey-blue shadows due to change in ice density, the spectacular staircases created by the seracs, and the contrast with the embedding rocks. A sub-set of the images will be presented in this context.

  13. Sleeping Beauty and the Story of the Bacille Calmette-Guérin Vaccine.

    PubMed

    Fletcher, Helen A

    2016-01-01

    Mycobacterium bovis BCG is the only available vaccine for protection against tuberculosis (TB). While BCG protects children from severe disease, it has little impact on pulmonary disease in adults. A recombinant BCG vaccine BCG ΔureC::hly (strain VPM1002) is in advanced clinical trials and shows promise for improved vaccine safety but little change in efficacy in animal models. A second-generation recombinant BCG vaccine with an additional deletion of the nuoG gene (BCG ΔureC::hly ΔnuoG) shows improved efficacy in a mouse model compared to that of VPM1002. BCG was first used in humans in 1921 and, like Sleeping Beauty pricked by the spinning wheel, we have slept for 100 years, showing a reluctance to invest in clinical development or in biomanufacturing capacity for TB vaccines. The advance of recombinant BCGs should awaken us from our sleep and call us to invest in new-generation TB vaccines and to protect the biomanufacture of our current BCG vaccine. PMID:27578760

  14. Transcriptionally regulated and nontoxic delivery of the hyperactive Sleeping Beauty Transposase

    PubMed Central

    Cocchiarella, Fabienne; Latella, Maria Carmela; Basile, Valentina; Miselli, Francesca; Galla, Melanie; Imbriano, Carol; Recchia, Alessandra

    2016-01-01

    The Sleeping Beauty (SB) transposase and, in particular, its hyperactive variant SB100X raises increasing interest for gene therapy application, including genome modification and, more recently, induced pluripotent stem cells (iPS) reprogramming. The documented cytotoxicity of the transposase, when constitutively expressed by an integrating retroviral vector (iRV), has been circumvented by the transient delivery of SB100X using retroviral mRNA transfer. In this study, we developed an alternative, safe, and efficient transposase delivery system based on a tetracycline-ON regulated expression cassette and the rtTA2S-M2 transactivator gene transiently delivered by integration-defective lentiviral vectors (IDLVs). Compared with iRV-mediated delivery, expression of tetracycline-induced SB100X delivered by an IDLV results in more efficient integration of a GFP transposon and reduced toxicity. Tightly regulated expression and reactivation of the transposase was achieved in HeLa cells as wells as in human primary keratinocytes. Based on these properties, the regulated transposase-IDLV vectors may represent a valuable tool for genetic engineering and therapeutic gene transfer. PMID:27574698

  15. Genomic Analysis of Sleeping Beauty Transposon Integration in Human Somatic Cells

    PubMed Central

    Turchiano, Giandomenico; Latella, Maria Carmela; Gogol-Döring, Andreas; Cattoglio, Claudia; Mavilio, Fulvio; Izsvák, Zsuzsanna; Ivics, Zoltán; Recchia, Alessandra

    2014-01-01

    The Sleeping Beauty (SB) transposon is a non-viral integrating vector system with proven efficacy for gene transfer and functional genomics. However, integration efficiency is negatively affected by the length of the transposon. To optimize the SB transposon machinery, the inverted repeats and the transposase gene underwent several modifications, resulting in the generation of the hyperactive SB100X transposase and of the high-capacity “sandwich” (SA) transposon. In this study, we report a side-by-side comparison of the SA and the widely used T2 arrangement of transposon vectors carrying increasing DNA cargoes, up to 18 kb. Clonal analysis of SA integrants in human epithelial cells and in immortalized keratinocytes demonstrates stability and integrity of the transposon independently from the cargo size and copy number-dependent expression of the cargo cassette. A genome-wide analysis of unambiguously mapped SA integrations in keratinocytes showed an almost random distribution, with an overrepresentation in repetitive elements (satellite, LINE and small RNAs) compared to a library representing insertions of the first-generation transposon vector and to gammaretroviral and lentiviral libraries. The SA transposon/SB100X integrating system therefore shows important features as a system for delivering large gene constructs for gene therapy applications. PMID:25390293

  16. Sleeping Beauty mutagenesis in a mouse medulloblastoma model defines networks that discriminate between human molecular subgroups

    PubMed Central

    Genovesi, Laura A.; Ng, Ching Ging; Davis, Melissa J.; Remke, Marc; Taylor, Michael D.; Adams, David J.; Rust, Alistair G.; Ward, Jerrold M.; Ban, Kenneth H.; Jenkins, Nancy A.; Copeland, Neal G.; Wainwright, Brandon J.

    2013-01-01

    The Sleeping Beauty (SB) transposon mutagenesis screen is a powerful tool to facilitate the discovery of cancer genes that drive tumorigenesis in mouse models. In this study, we sought to identify genes that functionally cooperate with sonic hedgehog signaling to initiate medulloblastoma (MB), a tumor of the cerebellum. By combining SB mutagenesis with Patched1 heterozygous mice (Ptch1lacZ/+), we observed an increased frequency of MB and decreased tumor-free survival compared with Ptch1lacZ/+ controls. From an analysis of 85 tumors, we identified 77 common insertion sites that map to 56 genes potentially driving increased tumorigenesis. The common insertion site genes identified in the mutagenesis screen were mapped to human orthologs, which were used to select probes and corresponding expression data from an independent set of previously described human MB samples, and surprisingly were capable of accurately clustering known molecular subgroups of MB, thereby defining common regulatory networks underlying all forms of MB irrespective of subgroup. We performed a network analysis to discover the likely mechanisms of action of subnetworks and used an in vivo model to confirm a role for a highly ranked candidate gene, Nfia, in promoting MB formation. Our analysis implicates candidate cancer genes in the deregulation of apoptosis and translational elongation, and reveals a strong signature of transcriptional regulation that will have broad impact on expression programs in MB. These networks provide functional insights into the complex biology of human MB and identify potential avenues for intervention common to all clinical subgroups. PMID:24167280

  17. The anxious production of beauty: Unruly bodies, surgical anxiety and invisible care.

    PubMed

    Leem, So Yeon

    2016-02-01

    This study is based on ethnographic fieldwork at a plastic surgery clinic in Seoul, South Korea. Examining the three phases of plastic--consultation, operation and recovery--I show how surgeons work to shape not only patients' bodies but also expectations and satisfaction. Surgeons do so in part to assuage their own anxieties, which arise from the possibility of misaligned beauty standards and unforeseen anatomies, as well as the possible dissatisfaction of the patient. I offer the concept of 'surgical anxiety', which occurs in relation to inherently unruly patient bodies in which worries, fear, frustration, self-pity, cynicism, anger and even loneliness are symptomatic. The unpredictability and uncontrollability of patients' bodies, which generates anxiety for both patients and surgeons, work to constrain the power of plastic surgery and making it inherently vulnerable. This study also pays attention to the invisible work of taking care of surgical anxiety, as practised by female staff members, and surgeons' dependence on these workers. My focus on anxiety is a kind of remedy for the predominant concern with 'ambivalence' in constructivist science and technology studies; rather than continue to highlight the power differentials between experts/practitioners and lay people/patients, this study illuminates surgical anxiety as their shared vulnerability. Thus, this study proposes a new politics of care in technoscience and medicine, which begins with anxiety. PMID:26983171

  18. Full-length Dysferlin Transfer by the Hyperactive Sleeping Beauty Transposase Restores Dysferlin-deficient Muscle.

    PubMed

    Escobar, Helena; Schöwel, Verena; Spuler, Simone; Marg, Andreas; Izsvák, Zsuzsanna

    2016-01-01

    Dysferlin-deficient muscular dystrophy is a progressive disease characterized by muscle weakness and wasting for which there is no treatment. It is caused by mutations in DYSF, a large, multiexonic gene that forms a coding sequence of 6.2 kb. Sleeping Beauty (SB) transposon is a nonviral gene transfer vector, already used in clinical trials. The hyperactive SB system consists of a transposon DNA sequence and a transposase protein, SB100X, that can integrate DNA over 10 kb into the target genome. We constructed an SB transposon-based vector to deliver full-length human DYSF cDNA into dysferlin-deficient H2K A/J myoblasts. We demonstrate proper dysferlin expression as well as highly efficient engraftment (>1,100 donor-derived fibers) of the engineered myoblasts in the skeletal muscle of dysferlin- and immunodeficient B6.Cg-Dysf(prmd) Prkdc(scid)/J (Scid/BLA/J) mice. Nonviral gene delivery of full-length human dysferlin into muscle cells, along with a successful and efficient transplantation into skeletal muscle are important advances towards successful gene therapy of dysferlin-deficient muscular dystrophy. PMID:26784637

  19. Numbers of Beauty: An Innovative Aesthetic Analysis for Orthognathic Surgery Treatment Planning.

    PubMed

    Marianetti, Tito Matteo; Gasparini, Giulio; Midulla, Giulia; Grippaudo, Cristina; Deli, Roberto; Cervelli, Daniele; Pelo, Sandro; Moro, Alessandro

    2016-01-01

    The aim of this study was to validate a new aesthetic analysis and establish the sagittal position of the maxilla on an ideal group of reference. We want to demonstrate the usefulness of these findings in the treatment planning of patients undergoing orthognathic surgery. We took a reference group of 81 Italian women participating in a national beauty contest in 2011 on which we performed Arnett's soft tissues cephalometric analysis and our new "Vertical Planning Line" analysis. We used the ideal values to elaborate the surgical treatment planning of a second group of 60 consecutive female patients affected by skeletal class III malocclusion. Finally we compared both pre- and postoperative pictures with the reference values of the ideal group. The ideal group of reference does not perfectly fit in Arnett's proposed norms. From the descriptive statistical comparison of the patients' values before and after orthognathic surgery with the reference values we observed how all parameters considered got closer to the ideal population. We consider our "Vertical Planning Line" a useful help for orthodontist and surgeon in the treatment planning of patients with skeletal malocclusions, in combination with the clinical facial examination and the classical cephalometric analysis of bone structures. PMID:27110566

  20. Study of W boson production in association with beauty and charm

    NASA Astrophysics Data System (ADS)

    Aaij, R.; Adeva, B.; Adinolfi, M.; Affolder, A.; Ajaltouni, Z.; Akar, S.; Albrecht, J.; Alessio, F.; Alexander, M.; Ali, S.; Alkhazov, G.; Alvarez Cartelle, P.; Alves, A. A.; Amato, S.; Amerio, S.; Amhis, Y.; An, L.; Anderlini, L.; Anderson, J.; Andreotti, M.; Andrews, J. E.; Appleby, R. B.; Aquines Gutierrez, O.; Archilli, F.; d'Argent, P.; Artamonov, A.; Artuso, M.; Aslanides, E.; Auriemma, G.; Baalouch, M.; Bachmann, S.; Back, J. J.; Badalov, A.; Baesso, C.; Baldini, W.; Barlow, R. J.; Barschel, C.; Barsuk, S.; Barter, W.; Batozskaya, V.; Battista, V.; Bay, A.; Beaucourt, L.; Beddow, J.; Bedeschi, F.; Bediaga, I.; Bel, L. J.; Belyaev, I.; Ben-Haim, E.; Bencivenni, G.; Benson, S.; Benton, J.; Berezhnoy, A.; Bernet, R.; Bertolin, A.; Bettler, M.-O.; van Beuzekom, M.; Bien, A.; Bifani, S.; Bird, T.; Birnkraut, A.; Bizzeti, A.; Blake, T.; Blanc, F.; Blouw, J.; Blusk, S.; Bocci, V.; Bondar, A.; Bondar, N.; Bonivento, W.; Borghi, S.; Borsato, M.; Bowcock, T. J. V.; Bowen, E.; Bozzi, C.; Braun, S.; Brett, D.; Britsch, M.; Britton, T.; Brodzicka, J.; Brook, N. H.; Bursche, A.; Buytaert, J.; Cadeddu, S.; Calabrese, R.; Calvi, M.; Calvo Gomez, M.; Campana, P.; Campora Perez, D.; Capriotti, L.; Carbone, A.; Carboni, G.; Cardinale, R.; Cardini, A.; Carniti, P.; Carson, L.; Carvalho Akiba, K.; Casse, G.; Cassina, L.; Castillo Garcia, L.; Cattaneo, M.; Cauet, Ch.; Cavallero, G.; Cenci, R.; Charles, M.; Charpentier, Ph.; Chefdeville, M.; Chen, S.; Cheung, S.-F.; Chiapolini, N.; Chrzaszcz, M.; Cid Vidal, X.; Ciezarek, G.; Clarke, P. E. L.; Clemencic, M.; Cliff, H. V.; Closier, J.; Coco, V.; Cogan, J.; Cogneras, E.; Cogoni, V.; Cojocariu, L.; Collazuol, G.; Collins, P.; Comerma-Montells, A.; Contu, A.; Cook, A.; Coombes, M.; Coquereau, S.; Corti, G.; Corvo, M.; Couturier, B.; Cowan, G. A.; Craik, D. C.; Crocombe, A.; Cruz Torres, M.; Cunliffe, S.; Currie, R.; D'Ambrosio, C.; Dalseno, J.; David, P. N. Y.; Davis, A.; De Bruyn, K.; De Capua, S.; De Cian, M.; De Miranda, J. M.; De Paula, L.; De Silva, W.; De Simone, P.; Dean, C.-T.; Decamp, D.; Deckenhoff, M.; Del Buono, L.; Déléage, N.; Demmer, M.; Derkach, D.; Deschamps, O.; Dettori, F.; Di Canto, A.; Di Ruscio, F.; Dijkstra, H.; Donleavy, S.; Dordei, F.; Dorigo, M.; Dosil Suárez, A.; Dossett, D.; Dovbnya, A.; Dreimanis, K.; Dufour, L.; Dujany, G.; Dupertuis, F.; Durante, P.; Dzhelyadin, R.; Dziurda, A.; Dzyuba, A.; Easo, S.; Egede, U.; Egorychev, V.; Eidelman, S.; Eisenhardt, S.; Eitschberger, U.; Ekelhof, R.; Eklund, L.; El Rifai, I.; Elsasser, Ch.; Ely, S.; Esen, S.; Evans, H. M.; Evans, T.; Falabella, A.; Färber, C.; Farinelli, C.; Farley, N.; Farry, S.; Fay, R.; Ferguson, D.; Fernandez Albor, V.; Ferrari, F.; Ferreira Rodrigues, F.; Ferro-Luzzi, M.; Filippov, S.; Fiore, M.; Fiorini, M.; Firlej, M.; Fitzpatrick, C.; Fiutowski, T.; Fohl, K.; Fol, P.; Fontana, M.; Fontanelli, F.; Forty, R.; Francisco, O.; Frank, M.; Frei, C.; Frosini, M.; Fu, J.; Furfaro, E.; Gallas Torreira, A.; Galli, D.; Gallorini, S.; Gambetta, S.; Gandelman, M.; Gandini, P.; Gao, Y.; García Pardiñas, J.; Garofoli, J.; Garra Tico, J.; Garrido, L.; Gascon, D.; Gaspar, C.; Gastaldi, U.; Gauld, R.; Gavardi, L.; Gazzoni, G.; Geraci, A.; Gerick, D.; Gersabeck, E.; Gersabeck, M.; Gershon, T.; Ghez, Ph.; Gianelle, A.; Gianı, S.; Gibson, V.; Girard, O. G.; Giubega, L.; Gligorov, V. V.; Göbel, C.; Golubkov, D.; Golutvin, A.; Gomes, A.; Gotti, C.; Grabalosa Gándara, M.; Graciani Diaz, R.; Granado Cardoso, L. A.; Graugés, E.; Graverini, E.; Graziani, G.; Grecu, A.; Greening, E.; Gregson, S.; Griffith, P.; Grillo, L.; Grünberg, O.; Gui, B.; Gushchin, E.; Guz, Yu.; Gys, T.; Hadavizadeh, T.; Hadjivasiliou, C.; Haefeli, G.; Haen, C.; Haines, S. C.; Hall, S.; Hamilton, B.; Hampson, T.; Han, X.; Hansmann-Menzemer, S.; Harnew, N.; Harnew, S. T.; Harrison, J.; He, J.; Head, T.; Heijne, V.; Hennessy, K.; Henrard, P.; Henry, L.; Hernando Morata, J. A.; van Herwijnen, E.; Heß, M.; Hicheur, A.; Hill, D.; Hoballah, M.; Hombach, C.; Hulsbergen, W.; Humair, T.; Hussain, N.; Hutchcroft, D.; Hynds, D.; Idzik, M.; Ilten, P.; Jacobsson, R.; Jaeger, A.; Jalocha, J.; Jans, E.; Jawahery, A.; Jing, F.; John, M.; Johnson, D.; Jones, C. R.; Joram, C.; Jost, B.; Jurik, N.; Kandybei, S.; Kanso, W.; Karacson, M.; Karbach, T. M.; Karodia, S.; Kelsey, M.; Kenyon, I. R.; Kenzie, M.; Ketel, T.; Khanji, B.; Khurewathanakul, C.; Klaver, S.; Klimaszewski, K.; Kochebina, O.; Kolpin, M.; Komarov, I.; Koopman, R. F.; Koppenburg, P.; Korolev, M.; Kozeiha, M.; Kravchuk, L.; Kreplin, K.; Kreps, M.; Krocker, G.; Krokovny, P.; Kruse, F.; Kucewicz, W.; Kucharczyk, M.; Kudryavtsev, V.; Kuonen, A. K.; Kurek, K.; Kvaratskheliya, T.; La Thi, V. N.; Lacarrere, D.; Lafferty, G.; Lai, A.; Lambert, D.; Lambert, R. W.; Lanfranchi, G.; Langenbruch, C.

    2015-09-01

    The associated production of a W boson with a jet originating from either a light parton or heavy-flavor quark is studied in the forward region using proton-proton collisions. The analysis uses data corresponding to integrated luminosities of 1.0 and 2.0 fb-1 collected with the LHCb detector at center-of-mass energies of 7 and 8 TeV, respectively. The W bosons are reconstructed using the W →μ ν decay and muons with a transverse momentum, pT, larger than 20 GeV in the pseudorapidity range 2.0 <η <4.5 . The partons are reconstructed as jets with pT>20 GeV and 2.2 <η <4.2 . The sum of the muon and jet momenta must satisfy pT>20 GeV . The fraction of W +jet events that originate from beauty and charm quarks is measured, along with the charge asymmetries of the W +b and W +c production cross sections. The ratio of the W +jet to Z +jet production cross sections is also measured using the Z →μ μ decay. All results are in agreement with Standard Model predictions.

  1. Numbers of Beauty: An Innovative Aesthetic Analysis for Orthognathic Surgery Treatment Planning

    PubMed Central

    Marianetti, Tito Matteo; Gasparini, Giulio; Midulla, Giulia; Grippaudo, Cristina; Deli, Roberto; Cervelli, Daniele; Pelo, Sandro; Moro, Alessandro

    2016-01-01

    The aim of this study was to validate a new aesthetic analysis and establish the sagittal position of the maxilla on an ideal group of reference. We want to demonstrate the usefulness of these findings in the treatment planning of patients undergoing orthognathic surgery. We took a reference group of 81 Italian women participating in a national beauty contest in 2011 on which we performed Arnett's soft tissues cephalometric analysis and our new “Vertical Planning Line” analysis. We used the ideal values to elaborate the surgical treatment planning of a second group of 60 consecutive female patients affected by skeletal class III malocclusion. Finally we compared both pre- and postoperative pictures with the reference values of the ideal group. The ideal group of reference does not perfectly fit in Arnett's proposed norms. From the descriptive statistical comparison of the patients' values before and after orthognathic surgery with the reference values we observed how all parameters considered got closer to the ideal population. We consider our “Vertical Planning Line” a useful help for orthodontist and surgeon in the treatment planning of patients with skeletal malocclusions, in combination with the clinical facial examination and the classical cephalometric analysis of bone structures. PMID:27110566

  2. A Sleeping Beauty screen reveals NF-kB activation in CLL mouse model

    PubMed Central

    Zanesi, Nicola; Balatti, Veronica; Riordan, Jesse; Burch, Aaron; Rizzotto, Lara; Palamarchuk, Alexey; Cascione, Luciano; Lagana, Alessandro; Dupuy, Adam J.; Croce, Carlo M.

    2013-01-01

    TCL1 oncogene is overexpressed in aggressive form of human chronic lymphocytic leukemia (CLL) and its dysregulation in mouse B cells causes a CD5-positive leukemia similar to the aggressive form of human CLLs. To identify oncogenes that cooperate with Tcl1, we performed genetic screen in Eμ−TCL1 mice using Sleeping Beauty transposon-mediated mutagenesis. Analysis of transposon common insertion sites identified 7 genes activated by transposon insertions. Overexpression of these genes in mouse CLL was confirmed by real time reverse transcription-polymerase chain reaction. Interestingly, the main known function of 4 of 7 genes (Nfkb1, Tab2, Map3K14, and Nfkbid) is participation in or activation of the nuclear factor-kB (NF-kB) pathway. In addition, activation of the NF-kB is 1 of main functions of Akt2, also identified in the screen. These findings demonstrate cooperation of Tcl1 and the NF-kB pathway in the pathogenesis of aggressive CLL. Identification cooperating cancer genes will result in the development of combinatorial therapies to treat CLL. PMID:23591791

  3. Sleeping Beauty transposon insertional mutagenesis based mouse models for cancer gene discovery

    PubMed Central

    Moriarity, Branden S; Largaespada, David A

    2016-01-01

    Large-scale genomic efforts to study human cancer, such as the cancer gene atlas (TCGA), have identified numerous cancer drivers in a wide variety of tumor types. However, there are limitations to this approach, the mutations and expression or copy number changes that are identified are not always clearly functionally relevant, and only annotated genes and genetic elements are thoroughly queried. The use of complimentary, nonbiased, functional approaches to identify drivers of cancer development and progression is ideal to maximize the rate at which cancer discoveries are achieved. One such approach that has been successful is the use of the Sleeping Beauty (SB) transposon-based mutagenesis system in mice. This system uses a conditionally expressed transposase and mutagenic transposon allele to target mutagenesis to somatic cells of a given tissue in mice to cause random mutations leading to tumor development. Analysis of tumors for transposon common insertion sites (CIS) identifies candidate cancer genes specific to that tumor type. While similar screens have been performed in mice with the PiggyBac (PB) transposon and viral approaches, we limit extensive discussion to SB. Here we discuss the basic structure of these screens, screens that have been performed, methods used to identify CIS. PMID:26051241

  4. Sleeping Beauty and the Story of the Bacille Calmette-Guérin Vaccine

    PubMed Central

    2016-01-01

    ABSTRACT Mycobacterium bovis BCG is the only available vaccine for protection against tuberculosis (TB). While BCG protects children from severe disease, it has little impact on pulmonary disease in adults. A recombinant BCG vaccine BCG ΔureC::hly (strain VPM1002) is in advanced clinical trials and shows promise for improved vaccine safety but little change in efficacy in animal models. A second-generation recombinant BCG vaccine with an additional deletion of the nuoG gene (BCG ΔureC::hly ΔnuoG) shows improved efficacy in a mouse model compared to that of VPM1002. BCG was first used in humans in 1921 and, like Sleeping Beauty pricked by the spinning wheel, we have slept for 100 years, showing a reluctance to invest in clinical development or in biomanufacturing capacity for TB vaccines. The advance of recombinant BCGs should awaken us from our sleep and call us to invest in new-generation TB vaccines and to protect the biomanufacture of our current BCG vaccine. PMID:27578760

  5. Sleeping Beauty-Mediated Drug Resistance Gene Transfer in Human Hematopoietic Progenitor Cells.

    PubMed

    Hyland, Kendra A; Olson, Erik R; McIvor, R Scott

    2015-10-01

    The Sleeping Beauty (SB) transposon system can insert sequences into mammalian chromosomes, supporting long-term expression of both reporter and therapeutic genes. Hematopoietic progenitor cells (HPCs) are an ideal therapeutic gene transfer target as they are used in therapy for a variety of hematologic and metabolic conditions. As successful SB-mediated gene transfer into human CD34(+) HPCs has been reported by several laboratories, we sought to extend these studies to the introduction of a therapeutic gene conferring resistance to methotrexate (MTX), potentially providing a chemoprotective effect after engraftment. SB-mediated transposition of hematopoietic progenitors, using a transposon encoding an L22Y variant dihydrofolate reductase fused to green fluorescent protein, conferred resistance to methotrexate and dipyridamole, a nucleoside transport inhibitor that tightens MTX selection conditions, as assessed by in vitro hematopoietic colony formation. Transposition of individual transgenes was confirmed by sequence analysis of transposon-chromosome junctions recovered by linear amplification-mediated PCR. These studies demonstrate the potential of SB-mediated transposition of HPCs for expression of drug resistance genes for selective and chemoprotective applications. PMID:26176276

  6. Sleeping Beauty system to redirect T-cell specificity for human applications

    PubMed Central

    Maiti, Sourindra; Huls, Helen; Singh, Harjeet; Dawson, Margaret; Figliola, Matthew; Olivares, Simon; Rao, Pullavathi; Jue, Yi; Multani, Asha; Yang, Ge; Zhang, Ling; Kellar, Denise; Ang, Sonny; Torikai, Hiroki; Rabinovich, Brian; Lee, Dean A.; Kebriaei, Partow; Hackett, Perry; Champlin, Richard E.; Cooper, Laurence J.N.

    2013-01-01

    The Sleeping Beauty (SB) transposon/transposase DNA plasmid system is used to genetically modify cells for long-term transgene expression. We adapted the SB system for human application and generated T cells expressing a chimeric antigen receptor (CAR) specific for CD19. Electro-transfer of CD19-specific SB DNA plasmids in PBMC and propagation on CD19+ artificial antigen presenting cells (aAPC) was used to numerically expand CD3+ T cells expressing CAR. By Day 28 of co-culture >90% of expanded CD3+ T cells expressed CAR. CAR+ T cells specifically killed CD19+ target cells and consisted of subsets expressing biomarkers consistent with central memory, ieffector memory, and effector phenotypes. CAR+ T cells contracted numerically in the absence of CD19 antigen, did not express SB11 transposase, and maintained a polyclonal TCRVα and TCRVβ repertoire. Quantitative fluorescence in situ hybridization (Q-FISH) revealed that CAR+ T cells preserved telomere length. Quantitative PCR (Q-PCR) and FISH showed CAR transposon integrated on average once per T-cell genome. CAR+ T cells in peripheral blood can be detected by Q-PCR at a sensitivity of 0.01%. These findings lay the groundwork as the basis of our first-in-human clinical trials of the non-viral SB system for the investigational treatment of CD19+ B-cell malignancies (currently under three INDs #: 14193, 14577, and 14739). PMID:23377665

  7. Hidden beauty baryon states in the local hidden gauge approach with heavy quark spin symmetry

    NASA Astrophysics Data System (ADS)

    Xiao, C. W.; Oset, E.

    2013-11-01

    Using a coupled-channel unitary approach, combining the heavy quark spin symmetry and the dynamics of the local hidden gauge, we investigate the meson-baryon interaction with hidden beauty and obtain several new states of N around 11 GeV. We consider the basis of states η b N, ϒN, BΛ b , BΣ b , B * Λ b , B * Σ b , B * Σ {/b *} and find four basic bound states which correspond to BΣ b , BΣ {/b *}, B * Σ b and B * Σ {/b *}, decaying mostly into η b N and ϒN and with a binding energy about 50-130 MeV with respect to the thresholds of the corresponding channel. All of them have isospin I = 1/2 , and we find no bound states or resonances in I = 3/2 . The BΣ b state appears in J = 1/2 , the BΣ {/b *} in J = 3/2 , the B * Σ b appears nearly degenerate in J = 1/2 , 3/2 and the B * Σ {/b *} appears nearly degenerate in J = 1/2 , 3/2, 5/2. These states have a width from 2-110 MeV, with conservative estimates of uncertainties, except for the one in J = 5/2 which has zero width since it cannot decay into any of the states of the basis chosen. We make generous estimates of the uncertainties and find that within very large margins these states appear bound.

  8. Strong, athletic and beautiful: Edmondo De Amicis and the ideal Italian woman.

    PubMed

    Chapman, David; Gori, Gigliola

    2010-01-01

    Edmondo De Amicis (1843-1908) was one of Italy's most popular writers, and perhaps more than any other figure in post-Risorgimento Italy, he reflected the common hopes, dreams and prejudices of his countrymen. De Amicis was particularly interested in gymnastics and physical education, and he wrote about them frequently. His most famous work on these subjects is his novella Amore e ginnastica [Love and Gymnastics] (1892) which explores female fitness, sexual stereotypes and gender roles in nineteenth-century Italy. This opus, along with two others (a lecture and a magazine article), can help modern readers understand the role of female sport and gender expectations in post-Risorgimento Italy. In addition to exploring women's gymnastics, De Amicis was also interested in female mountain climbing. By examining the activities and physical appearance of lady mountaineers, the author reveals his personal criteria for the perfect woman. When these are combined with the gymnasts in the earlier work, we can distill the writer's own particular attitudes toward gender and female perfection. For De Amicis a woman was required to be athletic, beautiful, modest, faithful, loving and with just a soupon of uncertainty about her sexuality to make her interesting. PMID:20653115

  9. Assessment: Cinderella or Sleeping Beauty? Evolution of final examinations at the Royal Veterinary College.

    PubMed

    Pead, Matthew J

    2008-01-01

    Teachers of veterinary medicine frequently regard assessment as a Cinderella subject. Consciously or unconsciously, they allow assessment systems to become faithful slaves, brought out and dusted off when required, out of sight and out of mind at other times. This often means that assessment is last on the priority list when educational development is considered. Pedagogical literature is full of references to the power of appropriate assessment systems and the role that they can play in shaping and driving the learning environment. "Assessment drives learning" and "Students respect what is inspected" are the headlines associated with such references, and this viewpoint places assessment much more in the role of a Sleeping Beauty, requiring only a simple touch to become a vehicle for modernizing an educational system. This article uses an example of change to a UK veterinary final examination to present the tensions between these contrasting views, and some solutions for them, in an effort to fuel the debate on improving the use of assessment. PMID:19228916

  10. Microfabricated particle focusing device

    DOEpatents

    Ravula, Surendra K.; Arrington, Christian L.; Sigman, Jennifer K.; Branch, Darren W.; Brener, Igal; Clem, Paul G.; James, Conrad D.; Hill, Martyn; Boltryk, Rosemary June

    2013-04-23

    A microfabricated particle focusing device comprises an acoustic portion to preconcentrate particles over large spatial dimensions into particle streams and a dielectrophoretic portion for finer particle focusing into single-file columns. The device can be used for high throughput assays for which it is necessary to isolate and investigate small bundles of particles and single particles.

  11. Measurement of beauty-hadron decay electrons in Pb-Pb collisions at \\sqrt{s_{NN}} = 2.76 TeV with ALICE

    NASA Astrophysics Data System (ADS)

    Völk, Martin; ALICE Collaboration

    2015-05-01

    The ALICE Collaboration at the LHC studies heavy-ion collisions to investigate the properties of the Quark-Gluon Plasma (QGP). Heavy quarks (charm and beauty) are effective probes for this purpose. Both their energy loss in the medium as well as their possible thermalization yield information about the medium properties. In ALICE, the reconstruction of exclusive decays is currently accessible for charm, but not for beauty hadrons. For hadrons with beauty valence quarks a promising strategy is the measurement of their decay electrons. To separate these from the background electrons (mainly from charm hadron decays, photon conversions or light-meson decays) the large decay length of beauty hadrons can be utilized. It leads to a relatively large typical impact parameter of the decay electrons. By comparing the impact parameter distribution of the signal electrons with those from the background sources, the signal can be statistically separated from the background. For this purpose a maximum likelihood fit is employed using impact parameter distribution templates from simulations. The resulting nuclear modification factor for electrons from beauty-hadron decays shows a sizeable suppression for pT > 3 GeV/c, albeit still with large uncertainties.

  12. Musical beauty and information compression: Complex to the ear but simple to the mind?

    PubMed Central

    2011-01-01

    Background The biological origin of music, its universal appeal across human cultures and the cause of its beauty remain mysteries. For example, why is Ludwig Van Beethoven considered a musical genius but Kylie Minogue is not? Possible answers to these questions will be framed in the context of Information Theory. Presentation of the Hypothesis The entire life-long sensory data stream of a human is enormous. The adaptive solution to this problem of scale is information compression, thought to have evolved to better handle, interpret and store sensory data. In modern humans highly sophisticated information compression is clearly manifest in philosophical, mathematical and scientific insights. For example, the Laws of Physics explain apparently complex observations with simple rules. Deep cognitive insights are reported as intrinsically satisfying, implying that at some point in evolution, the practice of successful information compression became linked to the physiological reward system. I hypothesise that the establishment of this "compression and pleasure" connection paved the way for musical appreciation, which subsequently became free (perhaps even inevitable) to emerge once audio compression had become intrinsically pleasurable in its own right. Testing the Hypothesis For a range of compositions, empirically determine the relationship between the listener's pleasure and "lossless" audio compression. I hypothesise that enduring musical masterpieces will possess an interesting objective property: despite apparent complexity, they will also exhibit high compressibility. Implications of the Hypothesis Artistic masterpieces and deep Scientific insights share the common process of data compression. Musical appreciation is a parasite on a much deeper information processing capacity. The coalescence of mathematical and musical talent in exceptional individuals has a parsimonious explanation. Musical geniuses are skilled in composing music that appears highly complex to

  13. β-globin matrix attachment region improves stable genomic expression of the Sleeping Beauty transposon.

    PubMed

    Sjeklocha, Lucas; Chen, Yixin; Daly, Meghan C; Steer, Clifford J; Kren, Betsy T

    2011-09-01

    The liver is an attractive target for gene therapy due to its extensive capability for protein production and the numerous diseases resulting from a loss of gene function it normally provides. The Sleeping Beauty Transposon (SB-Tn)(1) system is a non-viral vector capable of delivering and mediating therapeutic transgene(s) insertion into the host genome for long-term expression. A current challenge for this system is the low efficiency of integration of the transgene. In this study we use a human hepatoma cell line (HuH-7) and primary human blood outgrowth endothelial cells (BOECs) to test vectors containing DNA elements to enhance transposition without integrating themselves. We employed the human β-globin matrix attachment region (MAR) and the Simian virus 40 (SV40) nuclear translocation signal to increase the percent of HuH-7 cells persistently expressing a GFP::Zeo reporter construct by ∼50% for each element; while combining both did not show an additive effect. Interestingly, both elements together displayed an additive effect on the number of insertion sites, and in BOECs the SV40 alone appeared to have an inhibitory effect on transposition. In long-term cultures the loss of plasmid DNA, transposase expression and mapping of insertion sites demonstrated bona fide transposition without episomal expression. These results show that addition of the β-globin MAR and potentially other elements to the backbone of SB-Tn system can enhance transposition and expression of therapeutic transgenes. These findings may have a significant influence on the use of SB transgene delivery to liver for the treatment of a wide variety of disorders. PMID:21520245

  14. Novel strategies for gene trapping and insertional mutagenesis mediated by Sleeping Beauty transposon

    PubMed Central

    Song, Guili; Cui, Zongbin

    2013-01-01

    Gene and poly(A) trappings are high-throughput approaches to capture and interrupt the expression of endogenous genes within a target genome. Although a number of trapping vectors have been developed for investigation of gene functions in cells and vertebrate models, there is still room for the improvement of their efficiency and sensitivity. Recently, two novel trapping vectors mediated by Sleeping Beauty (SB) transposon have been generated by the combination of three functional cassettes that are required for finding endogenous genes, disrupting the expression of trapped genes, and inducing the excision of integrated traps from their original insertion sites and then inserting into another gene. In addition, several other strategies are utilized to improve the activities of two trapping vectors. First, activities of all components were examined in vitro before the generation of two vectors. Second, the inducible promoter from the tilapia Hsp70 gene was used to drive the expression of SB gene, which can mediate the excision of integrated transposons upon induction at 37 °C. Third, the Cre/LoxP system was introduced to delete the SB expression cassette for stabilization of gene interruption and bio-safety. Fourth, three stop codons in different reading frames were introduced downstream of a strong splice acceptor (SA) in the gene trapping vector to effectively terminate the translation of trapped endogenous genes. Fifth, the strong splicing donor (SD) and AU-rich RNA-destabilizing element exhibited no obvious insertion bias and markedly reduced SD read-through events, and the combination of an enhanced SA, a poly(A) signal and a transcript terminator in the poly(A) trapping vector efficiently disrupted the transcription of trapped genes. Thus, these two trapping vectors are alternative and effective tools for large-scale identification and disruption of endogenous genes in vertebrate cells and animals. PMID:24251071

  15. Manipulating the sleeping beauty mutase operon for the production of 1-propanol in engineered Escherichia coli

    PubMed Central

    2013-01-01

    Background While most resources in biofuels were directed towards implementing bioethanol programs, 1-propanol has recently received attention as a promising alternative biofuel. Nevertheless, no microorganism has been identified as a natural 1-propanol producer. In this study, we manipulated a novel metabolic pathway for the synthesis of 1-propanol in the genetically tractable bacterium Escherichia coli. Results E. coli strains capable of producing heterologous 1-propanol were engineered by extending the dissimilation of succinate via propionyl-CoA. This was accomplished by expressing a selection of key genes, i.e. (1) three native genes in the sleeping beauty mutase (Sbm) operon, i.e. sbm-ygfD-ygfG from E. coli, (2) the genes encoding bifunctional aldehyde/alcohol dehydrogenases (ADHs) from several microbial sources, and (3) the sucCD gene encoding succinyl-CoA synthetase from E. coli. Using the developed whole-cell biocatalyst under anaerobic conditions, production titers up to 150 mg/L of 1-propanol were obtained. In addition, several genetic and chemical effects on the production of 1-propanol were investigated, indicating that certain host-gene deletions could abolish 1-propanol production as well as that the expression of a putative protein kinase (encoded by ygfD/argK) was crucial for 1-propanol biosynthesis. Conclusions The study has provided a novel route for 1-propanol production in E. coli, which is subjected to further improvement by identifying limiting conversion steps, shifting major carbon flux to the productive pathway, and optimizing gene expression and culture conditions. PMID:24074355

  16. Adaptive immunity does not strongly suppress spontaneous tumors in a Sleeping Beauty model of cancer

    PubMed Central

    Rogers, Laura M.; Olivier, Alicia K.; Meyerholz, David K.; Dupuy, Adam J.

    2013-01-01

    The tumor immunosurveillance hypothesis describes a process by which the immune system recognizes and suppresses the growth of transformed cancer cells. A variety of epidemiological and experimental evidence supports this hypothesis. Nevertheless, there are a number of conflicting reports regarding the degree of immune protection conferred, the immune cell types responsible for protection, and the potential contributions of immunosuppressive therapies to tumor induction. The purpose of this study was to determine whether the adaptive immune system actively suppresses tumorigenesis in a Sleeping Beauty (SB) mouse model of cancer. SB transposon mutagenesis was performed in either a wild-type or immunocompromised (Rag2-null) background. Tumor latency and multiplicity were remarkably similar in both immune cohorts, suggesting that the adaptive immune system is not efficiently suppressing tumor formation in our model. Exceptions included skin tumors, which displayed increased multiplicity in wild-type animals, and leukemias, which developed with shorter latency in immune-deficient mice. Overall tumor distribution was also altered such that tumors affecting the gastrointestinal tract were more frequent and hemangiosarcomas were less frequent in immune-deficient mice compared to wild-type mice. Finally, genetic profiling of transposon-induced mutations identified significant differences in mutation prevalence for a number of genes, including Uba1. Taken together, these results indicate that B- and T-cells function to shape the genetic profile of tumors in various tumor types, despite being ineffective at clearing SB-induced tumors. This study represents the first forward genetic screen designed to examine tumor immunosurveillance mechanisms. PMID:23475219

  17. Sleeping Beauty transposon mutagenesis identifies genes that cooperate with mutant Smad4 in gastric cancer development.

    PubMed

    Takeda, Haruna; Rust, Alistair G; Ward, Jerrold M; Yew, Christopher Chin Kuan; Jenkins, Nancy A; Copeland, Neal G

    2016-04-01

    Mutations in SMAD4 predispose to the development of gastrointestinal cancer, which is the third leading cause of cancer-related deaths. To identify genes driving gastric cancer (GC) development, we performed a Sleeping Beauty (SB) transposon mutagenesis screen in the stomach of Smad4(+/-) mutant mice. This screen identified 59 candidate GC trunk drivers and a much larger number of candidate GC progression genes. Strikingly, 22 SB-identified trunk drivers are known or candidate cancer genes, whereas four SB-identified trunk drivers, including PTEN, SMAD4, RNF43, and NF1, are known human GC trunk drivers. Similar to human GC, pathway analyses identified WNT, TGF-β, and PI3K-PTEN signaling, ubiquitin-mediated proteolysis, adherens junctions, and RNA degradation in addition to genes involved in chromatin modification and organization as highly deregulated pathways in GC. Comparative oncogenomic filtering of the complete list of SB-identified genes showed that they are highly enriched for genes mutated in human GC and identified many candidate human GC genes. Finally, by comparing our complete list of SB-identified genes against the list of mutated genes identified in five large-scale human GC sequencing studies, we identified LDL receptor-related protein 1B (LRP1B) as a previously unidentified human candidate GC tumor suppressor gene. In LRP1B, 129 mutations were found in 462 human GC samples sequenced, and LRP1B is one of the top 10 most deleted genes identified in a panel of 3,312 human cancers. SB mutagenesis has, thus, helped to catalog the cooperative molecular mechanisms driving SMAD4-induced GC growth and discover genes with potential clinical importance in human GC. PMID:27006499

  18. Suicidal Autointegration of Sleeping Beauty and piggyBac Transposons in Eukaryotic Cells

    PubMed Central

    Devaraj, Anatharam; Singh, Manvendra; Jimenez Orgaz, Ana; Chen, Jia-Xuan; Selbach, Matthias; Ivics, Zoltán; Izsvák, Zsuzsanna

    2014-01-01

    Transposons are discrete segments of DNA that have the distinctive ability to move and replicate within genomes across the tree of life. ‘Cut and paste’ DNA transposition involves excision from a donor locus and reintegration into a new locus in the genome. We studied molecular events following the excision steps of two eukaryotic DNA transposons, Sleeping Beauty (SB) and piggyBac (PB) that are widely used for genome manipulation in vertebrate species. SB originates from fish and PB from insects; thus, by introducing these transposons to human cells we aimed to monitor the process of establishing a transposon-host relationship in a naïve cellular environment. Similarly to retroviruses, neither SB nor PB is capable of self-avoidance because a significant portion of the excised transposons integrated back into its own genome in a suicidal process called autointegration. Barrier-to-autointegration factor (BANF1), a cellular co-factor of certain retroviruses, inhibited transposon autointegration, and was detected in higher-order protein complexes containing the SB transposase. Increasing size sensitized transposition for autointegration, consistent with elevated vulnerability of larger transposons. Both SB and PB were affected similarly by the size of the transposon in three different assays: excision, autointegration and productive transposition. Prior to reintegration, SB is completely separated from the donor molecule and followed an unbiased autointegration pattern, not associated with local hopping. Self-disruptive autointegration occurred at similar frequency for both transposons, while aberrant, pseudo-transposition events were more frequently observed for PB. PMID:24625543

  19. Reliable transgene-independent method for determining Sleeping Beauty transposon copy numbers

    PubMed Central

    2011-01-01

    Background The transposon-based gene delivery technique is emerging as a method of choice for gene therapy. The Sleeping Beauty (SB) system has become one of the most favored methods, because of its efficiency and its random integration profile. Copy-number determination of the delivered transgene is a crucial task, but a universal method for measuring this is lacking. In this paper, we show that a real-time quantitative PCR-based, transgene-independent (qPCR-TI) method is able to determine SB transposon copy numbers regardless of the genetic cargo. Results We designed a specific PCR assay to amplify the left inverted repeat-direct repeat region of SB, and used it together with the single-copy control gene RPPH1 and a reference genomic DNA of known copy number. The qPCR-TI method allowed rapid and accurate determination of SB transposon copy numbers in various cell types, including human embryonic stem cells. We also found that this sensitive, rapid, highly reproducible and non-radioactive method is just as accurate and reliable as the widely used blotting techniques or the transposon display method. Because the assay is specific for the inverted repeat region of the transposon, it could be used in any system where the SB transposon is the genetic vehicle. Conclusions We have developed a transgene-independent method to determine copy numbers of transgenes delivered by the SB transposon system. The technique is based on a quantitative real-time PCR detection method, offering a sensitive, non-radioactive, rapid and accurate approach, which has a potential to be used for gene therapy. PMID:21371313

  20. Prospecting for Diverse Igneous Rock Types on Mars: Pixl on "black Beauty" Nwa 7533

    NASA Astrophysics Data System (ADS)

    Liu, Y.; Flannery, D.; Allwood, A.; Thompson, D. R.; Hodyss, R. P.; Clark, B. C.; Elam, W. T.; Hurowitz, J.

    2015-12-01

    In order to understand the evolution of the Martian crust and mantle, we need to acquire and analyze samples of igneous rocks other than the basaltic and ultramafic lithologies represented by the majority of Martian meteorites. Recent results from the Curiosity Rover demonstrate that diverse rock types exist in some Martian sedimentary environments in the form of conglomerate components or float, some of which shed light on the nature of early Martian crust (e.g., Sautter et al., 2015). We are developing investigation strategies for the in-situ instruments that will be flown on the Mars 2020 rover. These instruments will be used to inform the sampling campaigns required for future sample return missions. To achieve this, we applied PIXL (Planetary Instrument for X-ray Lithochemistry), an instrument for the Mars 2020 rover mission, to the meteorite NWA 7533. This meteorite is a pairing of NWA 7034, known informally as "Black Beauty", a new type of Martian meteorite that is broadly similar to the average composition of the Martian crust. This type of meteorite is essentially a 'conglomerate', with many diverse rock types, including mafic, feldspathic, and exotic rock fragments such as feldspar-ilmenite-phosphate clasts, as observed using higher-spatial resolution and higher sensitivity laboratory instruments (e.g., Agee et al., 2013; Humayun et al., 2014; Santos et al., 2015). Using PIXL, we analyzed a mm-scale cut and polished surface and applied algorithms developed by the PIXL team to semi-autonomously define and group regions containing similar lithological components (Thompson et al., 2015). PIXL data rapidly reveal distinctive zircon-bearing lithologies and feldspar-ilmenite-phosphate clasts similar to the detailed petrographic and mineralogical observations. Results suggest that PIXL readily identifies lithologies with minerals and elements (e.g., Rb and Sr) that are important for geochronology studies.

  1. Leg Length, Body Proportion, and Health: A Review with a Note on Beauty

    PubMed Central

    Bogin, Barry; Varela-Silva, Maria Inês

    2010-01-01

    Decomposing stature into its major components is proving to be a useful strategy to assess the antecedents of disease, morbidity and death in adulthood. Human leg length (femur + tibia), sitting height (trunk length + head length) and their proportions, for example, (leg length/stature), or the sitting height ratio (sitting height/stature × 100), among others) are associated with epidemiological risk for overweight (fatness), coronary heart disease, diabetes, liver dysfunction and certain cancers. There is also wide support for the use of relative leg length as an indicator of the quality of the environment for growth during infancy, childhood and the juvenile years of development. Human beings follow a cephalo-caudal gradient of growth, the pattern of growth common to all mammals. A special feature of the human pattern is that between birth and puberty the legs grow relatively faster than other post-cranial body segments. For groups of children and youth, short stature due to relatively short legs (i.e., a high sitting height ratio) is generally a marker of an adverse environment. The development of human body proportions is the product of environmental x genomic interactions, although few if any specific genes are known. The HOXd and the short stature homeobox-containing gene (SHOX) are genomic regions that may be relevant to human body proportions. For example, one of the SHOX related disorders is Turner syndrome. However, research with non-pathological populations indicates that the environment is a more powerful force influencing leg length and body proportions than genes. Leg length and proportion are important in the perception of human beauty, which is often considered a sign of health and fertility. PMID:20617018

  2. Lifetime of heavy flavour particles

    SciTech Connect

    Lueth, V.

    1985-10-01

    Recent measurements of the lifetime of the tau leptons and charm and beauty hadrons are reviewed and their significance for the couplings of the charged weak current, flavour mixing, and models relating quarks to hadron decay are discussed. 70 refs., 17 figs., 5 tabs.

  3. Baryons with open beauty dynamically generated from meson-baryon interaction in the extended local hidden gauge approach

    NASA Astrophysics Data System (ADS)

    Liang, Wei-Hong; Xiao, C. W.; Oset, E.

    2016-05-01

    In this talk we review the results about the interaction of B ¯N , B ¯Δ, B ¯*N and B ¯*Δ states with beauty B = 1, together with their coupled channels, using the extended local hidden gauge approach. The Λb(5912) and Λb(5920) observed in the experiment are dynamically generated from the meson-baryon interaction, and they couple mostly to B ¯*N , which are degenerate with the Weinberg-Tomozawa interaction. In addition, three more states with I = 0 and eight more states with I = 1 are predicted.

  4. Sleeping Beauty transposon system harboring HRAS, c-Myc and shp53 induces sarcomatoid carcinomas in mouse skin.

    PubMed

    Jung, Sunyoung; Ro, Simon Weonsang; Jung, Geunyoung; Ju, Hye-Lim; Yu, Eun-Sil; Son, Woo-Chan

    2013-04-01

    The Sleeping Beauty transposon system is used as a tool for insertional mutagenesis and oncogenesis. However, little is known about the exact histological phenotype of the tumors induced. Thus, we used immunohistochemical markers to enable histological identification of the type of tumor induced by subcutaneous injection of the HRAS, c-Myc and shp53 oncogenes in female C57BL/6 mice. The tumor was removed when it reached 100 mm3 in volume. Subsequently, we used 13 immunohistochemical markers to histologically identify the tumor type. The results suggested that the morphology of the tumor was similar to that of sarcomatoid carcinoma. PMID:23380875

  5. Shapes, Proportions, and Variations in Breast Aesthetic Ideals: The Definition of Breast Beauty, Analysis, and Surgical Practice.

    PubMed

    Mallucci, Patrick; Branford, Olivier Alexandre

    2015-10-01

    There are few objective analyses in the plastic surgical literature to define an aesthetically pleasing template for breast shape and proportion. The authors previously identified key objective parameters that define breast aesthetic ideals in 2 studies: an observational analysis of 100 models with natural breasts, and a population analysis with 1315 respondents. From these data a simple yet reproducible formula for surgical planning in breast augmentation has been developed to consistently achieve beautiful breasts, namely the ICE principle. This article proposes that this principle be used as the basis for design in aesthetic breast surgery. PMID:26408436

  6. Sleeping Beauty transposon system harboring HRAS, c-Myc and shp53 induces sarcomatoid carcinomas in mouse skin

    PubMed Central

    JUNG, SUNYOUNG; RO, SIMON WEONSANG; JUNG, GEUNYOUNG; JU, HYE-LIM; YU, EUN-SIL; SON, WOO-CHAN

    2013-01-01

    The Sleeping Beauty transposon system is used as a tool for insertional mutagenesis and oncogenesis. However, little is known about the exact histological phenotype of the tumors induced. Thus, we used immunohistochemical markers to enable histological identification of the type of tumor induced by subcutaneous injection of the HRAS, c-Myc and shp53 oncogenes in female C57BL/6 mice. The tumor was removed when it reached 100 mm3 in volume. Subsequently, we used 13 immunohistochemical markers to histologically identify the tumor type. The results suggested that the morphology of the tumor was similar to that of sarcomatoid carcinoma. PMID:23380875

  7. Dynamic response of the scenic beauty value of different forests to various thinning intensities in central eastern China.

    PubMed

    Deng, Songqiu; Yin, Na; Guan, Qingwei; Katoh, Masato

    2014-11-01

    Forest management has a significant influence on the preferences of people for forest landscapes. This study sought to evaluate the dynamic effects of thinning intensities on the landscape value of forests over time. Five typical stands in Wuxiangsi National Forest Park in Nanjing, China, were subjected to a thinning experiment designed with four intensities: unthinned, light thinning, moderate thinning, and heavy thinning. People's preferences for landscape photographs taken in plots under various thinning intensities were assessed through scenic beauty estimation (SBE) at 2 and 5 years after thinning. The differences in scenic beauty value between different thinning intensities were then analyzed with a paired samples t test for the two periods. The results indicated that the landscape value of all of the thinned plots significantly exceeded that of the unthinned plots 2 years after thinning (p < 0.01) and that the heavily thinned plots were most appreciated, showing an average improvement of 9.71 % compared with the control plots. Additionally, the heavily thinned plots were judged to be more beautiful than the lightly thinned and moderately thinned plots, whereas there was no significant difference between moderate thinning and light thinning. At 5 years after thinning, however, the moderately thinned plots received the highest preference scores among the four intensities, displaying an average improvement of 11.32 % compared with the unthinned plots. A multiple linear regression (MLR) model indicated that landscape value improved with increases in the average diameter at breast height (DBH) and with the improvement of environmental cleanliness in the stand, whereas the value decreased with an increasing stem density, species diversity, litter coverage, and canopy density. In addition, we found that the performance of a neural network model based on a multilayer perception (MLP) algorithm for predicting scenic beauty was slightly better than that of

  8. The Folding of the Specific DNA Recognition Subdomain of the Sleeping Beauty Transposase Is Temperature-Dependent and Is Required for Its Binding to the Transposon DNA

    PubMed Central

    Leighton, Gage O.; Konnova, Tatiana A.; Idiyatullin, Bulat; Hurr, Sophia H.; Zuev, Yuriy F.; Nesmelova, Irina V.

    2014-01-01

    The reaction of DNA transposition begins when the transposase enzyme binds to the transposon DNA. Sleeping Beauty is a member of the mariner family of DNA transposons. Although it is an important tool in genetic applications and has been adapted for human gene therapy, its molecular mechanism remains obscure. Here, we show that only the folded conformation of the specific DNA recognition subdomain of the Sleeping Beauty transposase, the PAI subdomain, binds to the transposon DNA. Furthermore, we show that the PAI subdomain is well folded at low temperatures, but the presence of unfolded conformation gradually increases at temperatures above 15°C, suggesting that the choice of temperature may be important for the optimal transposase activity. Overall, the results provide a molecular-level insight into the DNA recognition by the Sleeping Beauty transposase. PMID:25375127

  9. Impact of pigmentary disorders on quality of life in Japan: Interest of the BeautyQoL instrument.

    PubMed

    Beresniak, Ariel; Auray, Jean-Paul; Duru, Gérard; Aractingi, Selim; Krueger, Gerald G; Talarico, Sergio; Adam, Anne-Sophie; Piot, Bertrand; Dupont, Danielle; de Linares, Yolaine

    2015-01-01

    Skin pigmentary disorders and uneven skin tone represent common cosmetic concerns in Japan where fairer skin is culturally desirable. As the demographics of Asian countries continue to evolve, there is a need to understand the impact of cosmetic skin concerns on quality of life (QoL). 199 Japanese women self-claiming facial skin pigmentation disorders were asked to complete the BeautyQoL questionnaire, and the results were compared with those of a control group of 200 women. Of the five dimensions of the BeautyQoL questionnaire, the dimension "mood" appeared to be significantly lower in the group presenting facial dark spots, as compared with the control group (p < 0.05). In the group presenting facial dark spots, the five dimensions and the global score showed that subjects concerned had lower scores than subjects less concerned, even if statistical significance was not reached. This study confirms that common pigmentary disorders such as facial black spots may negatively impact QoL. Further comparative studies with a controlled randomized design would be necessary to confirm these findings. PMID:25968164

  10. Case study: Beauty and the Beast 3D: benefits of 3D viewing for 2D to 3D conversion

    NASA Astrophysics Data System (ADS)

    Handy Turner, Tara

    2010-02-01

    From the earliest stages of the Beauty and the Beast 3D conversion project, the advantages of accurate desk-side 3D viewing was evident. While designing and testing the 2D to 3D conversion process, the engineering team at Walt Disney Animation Studios proposed a 3D viewing configuration that not only allowed artists to "compose" stereoscopic 3D but also improved efficiency by allowing artists to instantly detect which image features were essential to the stereoscopic appeal of a shot and which features had minimal or even negative impact. At a time when few commercial 3D monitors were available and few software packages provided 3D desk-side output, the team designed their own prototype devices and collaborated with vendors to create a "3D composing" workstation. This paper outlines the display technologies explored, final choices made for Beauty and the Beast 3D, wish-lists for future development and a few rules of thumb for composing compelling 2D to 3D conversions.

  11. Assessment of Fecundity and Germ Line Transmission in Two Transgenic Pig Lines Produced by Sleeping Beauty Transposition

    PubMed Central

    Garrels, Wiebke; Holler, Stephanie; Cleve, Nicole; Niemann, Heiner; Ivics, Zoltan; Kues, Wilfried A.

    2012-01-01

    Recently, we described a simplified injection method for producing transgenic pigs using a non-autonomous Sleeping Beauty transposon system. The founder animals showed ubiquitous expression of the Venus fluorophore in almost all cell types. To assess, whether expression of the reporter fluorophore affects animal welfare or fecundity, we analyzed reproductive parameters of two founder boars, germ line transmission, and organ and cell specific transgene expression in animals of the F1 and F2 generation. Molecular analysis of ejaculated sperm cells suggested three monomeric integrations of the Venus transposon in both founders. To test germ line transmission of the three monomeric transposon integrations, wild-type sows were artificially inseminated. The offspring were nursed to sexual maturity and hemizygous lines were established. A clear segregation of the monomeric transposons following the Mendelian rules was observed in the F1 and F2 offspring. Apparently, almost all somatic cells, as well as oocytes and spermatozoa, expressed the Venus fluorophore at cell-type specific levels. No detrimental effects of Venus expression on animal health or fecundity were found. Importantly, all hemizygous lines expressed the fluorophore in comparable levels, and no case of transgene silencing or variegated expression was found after germ line transmission, suggesting that the insertions occurred at transcriptionally permissive loci. The results show that Sleeping Beauty transposase-catalyzed transposition is a promising approach for stable genetic modification of the pig genome. PMID:24705079

  12. Particle Tracks in Aerogel

    NASA Technical Reports Server (NTRS)

    2005-01-01

    In an experiment using a special air gun, particles are shot into aerogel at high velocities. Closeup of particles that have been captured in aerogel are shown here. The particles leave a carrot-shaped trail in the aerogel. Aerogel was used on the Stardust spacecraft to capture comet particles from Comet Wild 2.

  13. Beauty and the iPod--A Story of Contrasts and the Use of Podcasting in Vocational Education--Nail Technology

    ERIC Educational Resources Information Center

    Naamani, Catherine; Taylor, Louise

    2012-01-01

    This paper takes a case study approach to provide evidence of the benefits of podcasting as a tool used to support a vocational qualification in the subject area of Hairdressing and Beauty Therapy (Nail Technology). It reflects on the experiences of both the lecturer and the students and concludes that podcasting is a valuable tool, supporting a…

  14. PiggyBac:A flexible and highly active transposon as compared to Sleeping Beauty, Tol2, and Mos1 in mammalian cells

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A non-viral vector for highly efficient site-specific integration would be desirable for many applications in transgenesis, including gene therapy. In this study, we directly compared the genomic integration efficiencies of piggyBac, hyperactive Sleeping Beauty(SB11), Tol2, and Mos1 in four mammalia...

  15. Oppressive Beliefs at Play: Associations among Beauty Ideals and Practices and Individual Differences in Sexism, Objectification of Others, and Media Exposure

    ERIC Educational Resources Information Center

    Swami, Viren; Coles, Rebecca; Wilson, Emma; Salem, Natalie; Wyrozumska, Karolina; Furnham, Adrian

    2010-01-01

    In recent years, beauty ideals and practices have been explained almost exclusively using evolutionary psychological frameworks, to the exclusion of more proximate factors such as psychosocial and individual psychological variables. To overcome this limitation, we examined the associations among sexist beliefs, objectification of others, media…

  16. The Effect of Blended Learning Approach on Fifth Grade Students' Academic Achievement in My Beautiful Language Textbook and the Development of Their Verbal Creative Thinking in Saudi Arabia

    ERIC Educational Resources Information Center

    Al-Madani, Feras Mohammed

    2015-01-01

    This study aims at investigating the effect of Blended Learning approach compared to the traditional learning approach on fifth grade students' achievement in My Beautiful Language Textbook and the development of their verbal creative thinking. The study consisted of 49 students among which 25 are males in the Experimental Group and 24 females in…

  17. Role of Sexual Objectification Experiences and Internalization of Standards of Beauty in Eating Disorder Symptomatology: A Test and Extension of Objectification Theory

    ERIC Educational Resources Information Center

    Moradi, Bonnie; Dirks, Danielle; Matteson, Alicia V.

    2005-01-01

    This study extends the literature on eating disorder symptomatology by testing, based on extant literature on objectification theory (B. L. Fredrickson & T. Roberts, 1997) and the role of sociocultural standards of beauty (e.g., L. J. Heinberg, J. K. Thompson, & S. Stormer, 1995), a model that examines (a) links of reported sexual objectification…

  18. Identification of Sleeping Beauty Transposon Insertions in Solid Tumors using Linker-mediated PCR

    PubMed Central

    Janik, Callie L.; Starr, Timothy K.

    2013-01-01

    Genomic, proteomic, transcriptomic, and epigenomic analyses of human tumors indicate that there are thousands of anomalies within each cancer genome compared to matched normal tissue. Based on these analyses it is evident that there are many undiscovered genetic drivers of cancer1. Unfortunately these drivers are hidden within a much larger number of passenger anomalies in the genome that do not directly contribute to tumor formation. Another aspect of the cancer genome is that there is considerable genetic heterogeneity within similar tumor types. Each tumor can harbor different mutations that provide a selective advantage for tumor formation2. Performing an unbiased forward genetic screen in mice provides the tools to generate tumors and analyze their genetic composition, while reducing the background of passenger mutations. The Sleeping Beauty (SB) transposon system is one such method3. The SB system utilizes mobile vectors (transposons) that can be inserted throughout the genome by the transposase enzyme. Mutations are limited to a specific cell type through the use of a conditional transposase allele that is activated by Cre Recombinase. Many mouse lines exist that express Cre Recombinase in specific tissues. By crossing one of these lines to the conditional transposase allele (e.g. Lox-stop-Lox-SB11), the SB system is activated only in cells that express Cre Recombinase. The Cre Recombinase will excise a stop cassette that blocks expression of the transposase allele, thereby activating transposon mutagenesis within the designated cell type. An SB screen is initiated by breeding three strains of transgenic mice so that the experimental mice carry a conditional transposase allele, a concatamer of transposons, and a tissue-specific Cre Recombinase allele. These mice are allowed to age until tumors form and they become moribund. The mice are then necropsied and genomic DNA is isolated from the tumors. Next, the genomic DNA is subjected to linker-mediated-PCR (LM

  19. Identification of Sleeping Beauty transposon insertions in solid tumors using linker-mediated PCR.

    PubMed

    Janik, Callie L; Starr, Timothy K

    2013-01-01

    Genomic, proteomic, transcriptomic, and epigenomic analyses of human tumors indicate that there are thousands of anomalies within each cancer genome compared to matched normal tissue. Based on these analyses it is evident that there are many undiscovered genetic drivers of cancer(1). Unfortunately these drivers are hidden within a much larger number of passenger anomalies in the genome that do not directly contribute to tumor formation. Another aspect of the cancer genome is that there is considerable genetic heterogeneity within similar tumor types. Each tumor can harbor different mutations that provide a selective advantage for tumor formation(2). Performing an unbiased forward genetic screen in mice provides the tools to generate tumors and analyze their genetic composition, while reducing the background of passenger mutations. The Sleeping Beauty (SB) transposon system is one such method(3). The SB system utilizes mobile vectors (transposons) that can be inserted throughout the genome by the transposase enzyme. Mutations are limited to a specific cell type through the use of a conditional transposase allele that is activated by Cre Recombinase. Many mouse lines exist that express Cre Recombinase in specific tissues. By crossing one of these lines to the conditional transposase allele (e.g. Lox-stop-Lox-SB11), the SB system is activated only in cells that express Cre Recombinase. The Cre Recombinase will excise a stop cassette that blocks expression of the transposase allele, thereby activating transposon mutagenesis within the designated cell type. An SB screen is initiated by breeding three strains of transgenic mice so that the experimental mice carry a conditional transposase allele, a concatamer of transposons, and a tissue-specific Cre Recombinase allele. These mice are allowed to age until tumors form and they become moribund. The mice are then necropsied and genomic DNA is isolated from the tumors. Next, the genomic DNA is subjected to linker

  20. Particle capture device

    DOEpatents

    Jayne, John T.; Worsnop, Douglas R.

    2016-02-23

    In example embodiments, particle collection efficiency in aerosol analyzers and other particle measuring instruments is improved by a particle capture device that employs multiple collisions to decrease momentum of particles until the particles are collected (e.g., vaporized or come to rest). The particle collection device includes an aperture through which a focused particle beam enters. A collection enclosure is coupled to the aperture and has one or more internal surfaces against which particles of the focused beam collide. One or more features are employed in the collection enclosure to promote particles to collide multiple times within the enclosure, and thereby be vaporized or come to rest, rather than escape through the aperture.

  1. Laser particle sorter

    DOEpatents

    Martin, John C.; Buican, Tudor N.

    1989-01-01

    Method and apparatus for sorting particles, such as biological particles. A first laser defines an optical path having an intensity gradient which is effective to propel the particles along the path but which is sufficiently weak that the particles are not trapped in an axial direction. A probe laser beam interrogates the particles to identify predetermined phenotypical characteristics of the particles. A second laser beam intersects the driving first laser beam, wherein the second laser beam is activated by an output signal indicative of a predetermined characteristic. The second laser beam is switchable between a first intensity and a second intensity, where the first intensity is effective to displace selected particles from the driving laser beam and the second intensity is effective to propel selected particles along the deflection laser beam. The selected particles may then be propelled by the deflection beam to a location effective for further analysis.

  2. Laser particle sorter

    DOEpatents

    Martin, J.C.; Buican, T.N.

    1987-11-30

    Method and apparatus are provided for sorting particles, such as biological particles. A first laser is used to define an optical path having an intensity gradient which is effective to propel the particles along the path but which is sufficiently weak that the particles are not trapped in an axial direction. A probe laser beam is provided for interrogating the particles to identify predetermined phenotypical characteristics of the particles. A second laser beam is provided to intersect the driving first laser beam, wherein the second laser beam is activated by an output signal indicative of a predetermined characteristic. The second laser beam is switchable between a first intensity and a second intensity, where the first intensity is effective to displace selected particles from the driving laser beam and the second intensity is effective to propel selected particles along the deflection laser beam. The selected particles may then be propelled by the deflection beam to a location effective for further analysis. 2 figs.

  3. A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer.

    PubMed

    O'Donnell, Kathryn A; Keng, Vincent W; York, Brian; Reineke, Erin L; Seo, Daekwan; Fan, Danhua; Silverstein, Kevin A T; Schrum, Christina T; Xie, Wei Rose; Mularoni, Loris; Wheelan, Sarah J; Torbenson, Michael S; O'Malley, Bert W; Largaespada, David A; Boeke, Jef D

    2012-05-22

    The Sleeping Beauty (SB) transposon mutagenesis system is a powerful tool that facilitates the discovery of mutations that accelerate tumorigenesis. In this study, we sought to identify mutations that cooperate with MYC, one of the most commonly dysregulated genes in human malignancy. We performed a forward genetic screen with a mouse model of MYC-induced liver cancer using SB-mediated mutagenesis. We sequenced insertions in 63 liver tumor nodules and identified at least 16 genes/loci that contribute to accelerated tumor development. RNAi-mediated knockdown in a liver progenitor cell line further validate three of these genes, Ncoa2/Src-2, Zfx, and Dtnb, as tumor suppressors in liver cancer. Moreover, deletion of Ncoa2/Src-2 in mice predisposes to diethylnitrosamine-induced liver tumorigenesis. These findings reveal genes and pathways that functionally restrain MYC-mediated liver tumorigenesis and therefore may provide targets for cancer therapy. PMID:22556267

  4. "Universal" and ethnic ideals of beautiful buttocks are best obtained by autologous micro fat grafting and liposuction.

    PubMed

    Roberts, Thomas L; Weinfeld, Adam B; Bruner, Terrence W; Nguyen, Karl

    2006-07-01

    Recently there has been a dramatic increase in the number of patients seeking buttocks enhancement and in the degree of augmentation requested. To fulfill these requests,aesthetic plastic surgeons must understand the patient's personal requests and ethnic identity, as well as any universal ideal of proportions and contours that create the impression of beautiful buttocks. "Universally" perceived ideal buttocks are 1.4 times the circumference of the waist, which is consistent cross-culturally and throughout history. Beyond this are important ethnic differences in the image of perfect buttocks shape. The combination of autologous micro fat grafting and liposuction is the best and possibly only way to obtain various ideal shapes, and offers a lower incidence of complications compared with buttock implants. PMID:16818095

  5. CP Violation and Beauty Decays - A Case Study of High Impact, High Sensitivity and Even High Precision Physics

    NASA Astrophysics Data System (ADS)

    Bigi, I. I.

    The narrative of these lectures contains three main threads: (i) CP violation despite having so far been observed only in the decays of neutral kaons has been recognized as a phenomenon of truly fundamental importance. The KM ansatz constitutes the minimal implementation of CP violation: without requiring unknown degrees of freedom it can reproduce the known CP phenomenology in a nontrivial way. (ii) The physics of beauty hadrons - in particular their weak decays - opens a novel window onto fundamental dynamics: they usher in a new quark family (presumably the last one); they allow us to determine fundamental quantities of the Standard Model like the b quark mass and the CKM parameters V(cb), V(ub), V(ts) and V(td); they exhibit speedy or even rapid B0 - ¯ B0 oscillations. (iii) Heavy Quark Expansions allow us to treat B decays with an accuracy that would not have been thought possible a mere decade ago. These three threads are joined together in the following manner: (a) Huge CP asymmetries are predicted in B decays, which represents a decisive test of the KM paradigm for CP violation. (b) Some of these predictions are made with high parametric reliability, which (c) can be translated into numerical precision through the judicious employment of novel theoretical technologies. (d) Beauty decays thus provide us with a rich and promising field to search for New Physics and even study some of its salient features. At the end of it there might quite possibly be a New Paradigm for High Energy Physics. There will be some other threads woven into this tapestry: electric dipole moments, and CP violation in other strange and in charm decays.

  6. Comparison of oil refining and biodiesel production process between screw press and n-hexane techniques from beauty leaf feedstock

    NASA Astrophysics Data System (ADS)

    Bhuiya, M. M. K.; Rasul, M. G.; Khan, M. M. K.; Ashwath, N.

    2016-07-01

    The Beauty Leaf Tree (Callophylum inophyllum) is regarded as an alternative source of energy to produce 2nd generation biodiesel due to its potentiality as well as high oil yield content in the seed kernels. The treating process is indispensable during the biodiesel production process because it can augment the yield as well as quality of the product. Oil extracted from both mechanical screw press and solvent extraction using n-hexane was refined. Five replications each of 25 gm of crude oil for screw press and five replications each of 25 gm of crude oil for n-hexane were selected for refining as well as biodiesel conversion processes. The oil refining processes consists of degumming, neutralization as well as dewaxing. The degumming, neutralization and dewaxing processes were performed to remove all the gums (phosphorous-based compounds), free fatty acids, and waxes from the fresh crude oil before the biodiesel conversion process carried out, respectively. The results indicated that up to 73% and 81% of mass conversion efficiency of the refined oil in the screw press and n-hexane refining processes were obtained, respectively. It was also found that up to 88% and 90% of biodiesel were yielded in terms of mass conversion efficiency in the transesterification process for the screw press and n-hexane techniques, respectively. While the entire processes (refining and transesterification) were considered, the conversion of beauty leaf tree (BLT) refined oil into biodiesel was yielded up to 65% and 73% of mass conversion efficiency for the screw press and n-hexane techniques, respectively. Physico-chemical properties of crude and refined oil, and biodiesel were characterized according to the ASTM standards. Overall, BLT has the potential to contribute as an alternative energy source because of high mass conversion efficiency.

  7. Integration Profile and Safety of an Adenovirus Hybrid-Vector Utilizing Hyperactive Sleeping Beauty Transposase for Somatic Integration

    PubMed Central

    Zhang, Wenli; Muck-Hausl, Martin; Wang, Jichang; Sun, Chuanbo; Gebbing, Maren; Miskey, Csaba; Ivics, Zoltan; Izsvak, Zsuzsanna; Ehrhardt, Anja

    2013-01-01

    We recently developed adenovirus/transposase hybrid-vectors utilizing the previously described hyperactive Sleeping Beauty (SB) transposase HSB5 for somatic integration and we could show stabilized transgene expression in mice and a canine model for hemophilia B. However, the safety profile of these hybrid-vectors with respect to vector dose and genotoxicity remains to be investigated. Herein, we evaluated this hybrid-vector system in C57Bl/6 mice with escalating vector dose settings. We found that in all mice which received the hyperactive SB transposase, transgene expression levels were stabilized in a dose-dependent manner and that the highest vector dose was accompanied by fatalities in mice. To analyze potential genotoxic side-effects due to somatic integration into host chromosomes, we performed a genome-wide integration site analysis using linker-mediated PCR (LM-PCR) and linear amplification-mediated PCR (LAM-PCR). Analysis of genomic DNA samples obtained from HSB5 treated female and male mice revealed a total of 1327 unique transposition events. Overall the chromosomal distribution pattern was close-to-random and we observed a random integration profile with respect to integration into gene and non-gene areas. Notably, when using the LM-PCR protocol, 27 extra-chromosomal integration events were identified, most likely caused by transposon excision and subsequent transposition into the delivered adenoviral vector genome. In total, this study provides a careful evaluation of the safety profile of adenovirus/Sleeping Beauty transposase hybrid-vectors. The obtained information will be useful when designing future preclinical studies utilizing hybrid-vectors in small and large animal models. PMID:24124483

  8. Solar Neutral Particles

    NASA Video Gallery

    This animation shows a neutral solar particle's path leaving the sun, following the magnetic field lines out to the heliosheath. The solar particle hits a hydrogen atom, stealing its electron, and ...

  9. Particle exposures and infections

    EPA Science Inventory

    Particle exposures increase the risk for human infections. Particles can deposit in the nose, pharynx, larynx, trachea, bronchi, and distal lung and, accordingly, the respiratory tract is the system most frequently infected after such exposure; however, meningitis also occurs. Ci...

  10. Composite powder particles

    NASA Technical Reports Server (NTRS)

    Parker, Donald S. (Inventor); MacDowell, Louis G. (Inventor)

    2009-01-01

    A liquid coating composition including a coating vehicle and composite powder particles disposed within the coating vehicle. Each composite powder particle may include a magnesium component, a zinc component, and an indium component.

  11. Classical confined particles

    NASA Technical Reports Server (NTRS)

    Horzela, Andrzej; Kapuscik, Edward

    1993-01-01

    An alternative picture of classical many body mechanics is proposed. In this picture particles possess individual kinematics but are deprived from individual dynamics. Dynamics exists only for the many particle system as a whole. The theory is complete and allows to determine the trajectories of each particle. It is proposed to use our picture as a classical prototype for a realistic theory of confined particles.

  12. Magnetospheric particle populations.

    NASA Technical Reports Server (NTRS)

    Vette, J. I.

    1972-01-01

    Significant results of magnetospheric charged particle measurements conducted within the past two years are reviewed in an attempt to provide a general description of relationships among particle populations in the magnetosheath, plasma sheet, extraterrestrial ring current region, electron trough, pseudotrapping region, and stable-trapping region. Special attention is given to the characteristics of protons, electrons, alpha particles, and particles with charge greater than three in the stable trapping region.

  13. Solar flare particle radiation

    NASA Technical Reports Server (NTRS)

    Lanzerotti, L. J.

    1972-01-01

    The characteristics of the solar particles accelerated by solar flares and subsequently observed near the orbit of the earth are studied. Considered are solar particle intensity-time profiles, the composition and spectra of solar flare events, and the propagation of solar particles in interplanetary space. The effects of solar particles at the earth, riometer observations of polar cap cosmic noise absorption events, and the production of solar cell damage at synchronous altitudes by solar protons are also discussed.

  14. High energy particle astronomy.

    NASA Technical Reports Server (NTRS)

    Buffington, A.; Muller, R. A.; Smith, L. H.; Smoot, G. F.

    1972-01-01

    Discussion of techniques currently used in high energy particle astronomy for measuring charged and neutral cosmic rays and their isotope and momentum distribution. Derived from methods developed for accelerator experiments in particle physics, these techniques help perform important particle astronomy experiments pertaining to nuclear cosmic ray and gamma ray research, electron and position probes, and antimatter searches.

  15. Review of particle properties

    SciTech Connect

    Wohl; Cahn, R.N.; Rittenberg, A.; Trippe, T.G.; Yost, G.P.; Porter, F.; Hernandez, J.J.; Montanet, L.; Hendrick, R.E.; Crawford, R.L.

    1984-04-01

    This review of the properties of leptons, mesons, and baryons is an updating of the Review of Particle Properties, Particle Data Group (Phys. Lett. 111B (1982)). Data are evaluated, listed, averaged, and summarized in tables. Numerous tables, figures, and formulae of interest to particle physicists are also included. A data booklet is available.

  16. Atmospheric particle sampler

    NASA Technical Reports Server (NTRS)

    Miller, C. G.; Stephens, J. B.

    1976-01-01

    Positive and/or negative pressure is used to trap airborne particles against a filter. Positive pressure is provided by low molecular weight gas (He or H) to achieve high particle velocity and high capture percentage. Trapped particles are examined under electron microscope.

  17. When is a Particle?

    ERIC Educational Resources Information Center

    Drell, Sidney D.

    1978-01-01

    Gives a new definition for the concept of the elementary particle in nuclear physics. Explains why the existance of the quark as an elementary particle could be an accepted fact even though it lacks what traditionally identifies a particle. Compares this with the development which took place during the discovery of the neutrino in the early…

  18. Anatomy of Particle Diffusion

    ERIC Educational Resources Information Center

    Bringuier, E.

    2009-01-01

    The paper analyses particle diffusion from a thermodynamic standpoint. The main goal of the paper is to highlight the conceptual connection between particle diffusion, which belongs to non-equilibrium statistical physics, and mechanics, which deals with particle motion, at the level of third-year university courses. We start out from the fact…

  19. Particle film technology

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Particle Film Technology involves establishing a mineral particle film on the surface of a plant or plant product that: (1) is chemically inert, (2) has a mean particle diameter < 2 um, (3) is formulated to spread and create a uniform film, (4) does not physically disrupt gas exchange from the le...

  20. Dust particle velocity measurement

    NASA Technical Reports Server (NTRS)

    Thielman, L. O.

    1976-01-01

    A laser Doppler velocimeter was used to measure the velocity distributions for particles entering a vacuum chamber from the atmosphere through calibrated leaks. The relative number of particles per velocity interval was obtained for particulates of three size distributions and two densities passing through six different leak geometries. The velocity range 15 to 320 meters per second was investigated. Peak particle velocities were found to occur in the 15 to 150 meters per second range depending upon type of particle and leak geometry. A small fraction of the particles were found to have velocities in the 150 to 320 meters per second range.

  1. Adhesive particle shielding

    DOEpatents

    Klebanoff, Leonard Elliott; Rader, Daniel John; Walton, Christopher; Folta, James

    2009-01-06

    An efficient device for capturing fast moving particles has an adhesive particle shield that includes (i) a mounting panel and (ii) a film that is attached to the mounting panel wherein the outer surface of the film has an adhesive coating disposed thereon to capture particles contacting the outer surface. The shield can be employed to maintain a substantially particle free environment such as in photolithographic systems having critical surfaces, such as wafers, masks, and optics and in the tools used to make these components, that are sensitive to particle contamination. The shield can be portable to be positioned in hard-to-reach areas of a photolithography machine. The adhesive particle shield can incorporate cooling means to attract particles via the thermophoresis effect.

  2. Recent beauty results from CDF and the Run-II upgrades

    SciTech Connect

    Huffman, B.T.; CDF Collaboration

    1996-09-01

    This paper reports on the most recent results from the Collider Detector Facility (CDF) from 110 pb{sup -1} of data taken at the Fermilab Tevatron from 1992 to 1995. Improved measurements of B meson spectroscopy, lifetimes, and searches for new particle states are presented. Evidence for the effectiveness of same side tagging techniques in the context of mixing measurements is shown with applicability for CP violation studies in Run-II explained. The planned upgrades of importance to {ital b} physics for Run-II are briefly detailed with an emphasis on the expected physics reach in Run-II by CDF.

  3. Update to Proposal for an Experiment to Measure Mixing, CP Violation and rare Decays in Charm and Beauty Particle Decays at the Fermilac Collider - BTeV

    SciTech Connect

    Butler, Joel; Stone, Sheldon

    2002-03-01

    We have been requested to submit an update of the BTe V plan to the Fermilab Physics Advisory Committee, where to save money the detector has only one arm and there is no new interaction region magnet construction planned. These are to come from a currently running collider experiment at the appropriate time. The "Physics Case" section is complete and updated with the section on the "New Physics" capabilites of BTe V greatly expanded. We show that precise measurments of rare flavor-changing neutral current processes and CP violation are and will be complementary to the Tevatron and LHC to unraveling the electroweak breaking puzzle. We include a revised summary of the physics sensitivities for the one-arm detector, which are not simply taking our proposal numbers and dividing by two, because of additional improvements. One important change resulted from an improved understanding of just how important the RJCH detector is to muon and electron identification, that we can indeed separate electrons from pions and muons from pions, especially at relatively large angles beyond the physical appature of the EM calorimeter or the Muon Detector. This is documented in the "Physics Sensitivities" section. The section on the detector includes the motivation for doing band c physics at a hadron collider, and shows the changes in the detector since the proposal based on our ongoing R&D program. We do not here include a detailed description of the entire detector. That is available in the May, 2000 proposal.2 We include a summary of our R&D activities for the entire experiment. Finally, we also include a fully updated cost estimate for the one-arm system.

  4. Internalization of U.S. female beauty standards as a mediator of the relationship between Mexican American women's acculturation and body dissatisfaction.

    PubMed

    Poloskov, Elizabeth; Tracey, Terence J G

    2013-09-01

    The relationships among acculturation, internalization of U.S. sociocultural standards of female beauty, and body dissatisfaction were examined in a sample of 211 Mexican American college women. Structural equation modeling was used to identify the paths among these three factors. Results demonstrated that there are two distinct types of body dissatisfaction: global evaluations and composite site-specific evaluations. The relationships between acculturation toward dominant U.S. culture and both types of body dissatisfaction were found to be fully mediated by internalization of U.S. standards of female beauty. There were no relationships between Mexican orientation and any of the study variables. The results from this study imply that it is important for therapists working with Mexican American female clients to assess the client's level of acculturation, examine the cultural (U.S. and Mexican) messages the client receives, and explore how these messages impact her body image. PMID:23809859

  5. Fuzzy Logic Particle Tracking

    NASA Technical Reports Server (NTRS)

    2005-01-01

    A new all-electronic Particle Image Velocimetry technique that can efficiently map high speed gas flows has been developed in-house at the NASA Lewis Research Center. Particle Image Velocimetry is an optical technique for measuring the instantaneous two component velocity field across a planar region of a seeded flow field. A pulsed laser light sheet is used to illuminate the seed particles entrained in the flow field at two instances in time. One or more charged coupled device (CCD) cameras can be used to record the instantaneous positions of particles. Using the time between light sheet pulses and determining either the individual particle displacements or the average displacement of particles over a small subregion of the recorded image enables the calculation of the fluid velocity. Fuzzy logic minimizes the required operator intervention in identifying particles and computing velocity. Using two cameras that have the same view of the illumination plane yields two single exposure image frames. Two competing techniques that yield unambiguous velocity vector direction information have been widely used for reducing the single-exposure, multiple image frame data: (1) cross-correlation and (2) particle tracking. Correlation techniques yield averaged velocity estimates over subregions of the flow, whereas particle tracking techniques give individual particle velocity estimates. For the correlation technique, the correlation peak corresponding to the average displacement of particles across the subregion must be identified. Noise on the images and particle dropout result in misidentification of the true correlation peak. The subsequent velocity vector maps contain spurious vectors where the displacement peaks have been improperly identified. Typically these spurious vectors are replaced by a weighted average of the neighboring vectors, thereby decreasing the independence of the measurements. In this work, fuzzy logic techniques are used to determine the true

  6. Experiments with particle damping

    NASA Astrophysics Data System (ADS)

    Hollkamp, Joseph J.; Gordon, Robert W.

    1998-06-01

    High cycle fatigue in jet engines is a current military concern. The vibratory stresses that cause fatigue can be reduced by adding damping. However, the high temperatures that occur in the gas turbine greatly hinder the application of mature damping technologies. One technology which may perform in the harsh environment is particle damping. Particle damping involves placing metallic or ceramic particles inside structural cavities. As the cavity vibrates, energy is dissipated through particle collisions. Performance is influenced by many parameters including the type, shape, and size of the particles; the amount of free volume for the particles to move in; density of the particles; and the level of vibration. This paper presents results from a series of experiments designed to gain an appreciation of the important parameters. The experimental setup consists of a cantilever beam with drilled holes. These holes are partially filled with particles. The types of particles, location of the particles, fill level, and other parameters are varied. Damping is estimated for each configuration. Trends in the results are studied to determine the influence of the varied parameter.

  7. Stable, Nonviral Expression of Mutated Tumor Neoantigen-specific T-cell Receptors Using the Sleeping Beauty Transposon/Transposase System.

    PubMed

    Deniger, Drew C; Pasetto, Anna; Tran, Eric; Parkhurst, Maria R; Cohen, Cyrille J; Robbins, Paul F; Cooper, Laurence Jn; Rosenberg, Steven A

    2016-06-01

    Neoantigens unique to each patient's tumor can be recognized by autologous T cells through their T-cell receptor (TCR) but the low frequency and/or terminal differentiation of mutation-specific T cells in tumors can limit their utility as adoptive T-cell therapies. Transfer of TCR genes into younger T cells from peripheral blood with a high proliferative potential could obviate this problem. We generated a rapid, cost-effective strategy to genetically engineer cancer patient T cells with TCRs using the clinical Sleeping Beauty transposon/transposase system. Patient-specific TCRs reactive against HLA-A*0201-restriced neoantigens AHNAK(S2580F) or ERBB2(H473Y) or the HLA-DQB*0601-restricted neoantigen ERBB2IP(E805G) were assembled with murine constant chains and cloned into Sleeping Beauty transposons. Patient peripheral blood lymphocytes were coelectroporated with SB11 transposase and Sleeping Beauty transposon, and transposed T cells were enriched by sorting on murine TCRβ (mTCRβ) expression. Rapid expansion of mTCRβ(+) T cells with irradiated allogeneic peripheral blood lymphocytes feeders, OKT3, interleukin-2 (IL-2), IL-15, and IL-21 resulted in a preponderance of effector (CD27(-)CD45RA(-)) and less-differentiated (CD27(+)CD45RA(+)) T cells. Transposed T cells specifically mounted a polyfunctional response against cognate mutated neoantigens and tumor cell lines. Thus, Sleeping Beauty transposition of mutation-specific TCRs can facilitate the use of personalized T-cell therapy targeting unique neoantigens. PMID:26945006

  8. CLASHING BEAM PARTICLE ACCELERATOR

    DOEpatents

    Burleigh, R.J.

    1961-04-11

    A charged-particle accelerator of the proton synchrotron class having means for simultaneously accelerating two separate contra-rotating particle beams within a single annular magnet structure is reported. The magnet provides two concentric circular field regions of opposite magnetic polarity with one field region being of slightly less diameter than the other. The accelerator includes a deflector means straddling the two particle orbits and acting to collide the two particle beams after each has been accelerated to a desired energy. The deflector has the further property of returning particles which do not undergo collision to the regular orbits whereby the particles recirculate with the possibility of colliding upon subsequent passages through the deflector.

  9. Precision gap particle separator

    DOEpatents

    Benett, William J.; Miles, Robin; Jones, II., Leslie M.; Stockton, Cheryl

    2004-06-08

    A system for separating particles entrained in a fluid includes a base with a first channel and a second channel. A precision gap connects the first channel and the second channel. The precision gap is of a size that allows small particles to pass from the first channel into the second channel and prevents large particles from the first channel into the second channel. A cover is positioned over the base unit, the first channel, the precision gap, and the second channel. An port directs the fluid containing the entrained particles into the first channel. An output port directs the large particles out of the first channel. A port connected to the second channel directs the small particles out of the second channel.

  10. Particle formation and interaction

    NASA Technical Reports Server (NTRS)

    Squyres, Steven; Corso, George J.; Griffiths, Lynn D.; Mackinnon, Ian D. R.; Marshall, John R.; Nuth, Joseph A., III; Werner, Brad; Wolfe, John

    1987-01-01

    A wide variety of experiments can be conducted on the Space Station that involve the physics of small particles of planetary significance. Processes of interest include nucleation and condensation of particles from a gas, aggregation of small particles into larger ones, and low velocity collisions of particles. All of these processes could be investigated with a general purpose facility on the Space Station. The microgravity environment would be necessary to perform many experiments, as they generally require that particles be suspended for periods substantially longer than are practical at 1 g. Only experiments relevant to planetary processes will be discussed in detail here, but it is important to stress that a particle facility will be useful to a wide variety of scientific disciplines, and can be used to address many scientific problems.

  11. Particle Swarm Optimization

    NASA Technical Reports Server (NTRS)

    Venter, Gerhard; Sobieszczanski-Sobieski Jaroslaw

    2002-01-01

    The purpose of this paper is to show how the search algorithm known as particle swarm optimization performs. Here, particle swarm optimization is applied to structural design problems, but the method has a much wider range of possible applications. The paper's new contributions are improvements to the particle swarm optimization algorithm and conclusions and recommendations as to the utility of the algorithm, Results of numerical experiments for both continuous and discrete applications are presented in the paper. The results indicate that the particle swarm optimization algorithm does locate the constrained minimum design in continuous applications with very good precision, albeit at a much higher computational cost than that of a typical gradient based optimizer. However, the true potential of particle swarm optimization is primarily in applications with discrete and/or discontinuous functions and variables. Additionally, particle swarm optimization has the potential of efficient computation with very large numbers of concurrently operating processors.

  12. Methods for forming particles

    DOEpatents

    Fox, Robert V.; Zhang, Fengyan; Rodriguez, Rene G.; Pak, Joshua J.; Sun, Chivin

    2016-06-21

    Single source precursors or pre-copolymers of single source precursors are subjected to microwave radiation to form particles of a I-III-VI.sub.2 material. Such particles may be formed in a wurtzite phase and may be converted to a chalcopyrite phase by, for example, exposure to heat. The particles in the wurtzite phase may have a substantially hexagonal shape that enables stacking into ordered layers. The particles in the wurtzite phase may be mixed with particles in the chalcopyrite phase (i.e., chalcopyrite nanoparticles) that may fill voids within the ordered layers of the particles in the wurtzite phase thus produce films with good coverage. In some embodiments, the methods are used to form layers of semiconductor materials comprising a I-III-VI.sub.2 material. Devices such as, for example, thin-film solar cells may be fabricated using such methods.

  13. Beauty at HERA-B : Measurement of the bb Production Cross Section in pN Collisions at sqrt(s) = 41.6 GeV

    NASA Astrophysics Data System (ADS)

    Mevius, Maaijke

    2003-04-01

    This thesis reports on the measurement of the bb production cross section using the 2000 dataset of the HERA-B experiment. HERA-B is a fixed target experiment using the 920 GeV protons of the HERA accelerator of DESY, Hamburg. The production cross section of beauty quarks in pN collisions at fixed target energies is not well known. The two existing measurements are inconsistent and suffer from large errors. Theoretical calculations contain large uncertainties. A measurement by HERA-B could contribute to a better understanding of bb hadroprodution. The experiment is built as a forward spectrometer with multiple tracking and particle identification devices. Target wires of different materials can be moved into the halo of the proton beam to obtain the desired interaction rate. The trigger is designed to select the two leptons from J/psi->l+l- decays, both in the muon and in the electron channel. In this thesis only the electron channel was considered. The electron triggered events were used to search for evidence of the b->J/psiX->e+e-X decay. Most of the J/psi are produced directly at the interaction of the proton with the target. Only about 1 per 1000 J/psi is the decay product of a B meson. We measured the bb production cross section relative to the known cross section of the prompt J/psi, making use of the known branching ratio Br(bb->J/psiX). Many of the systematic uncertainties in trigger and detector efficiencies cancel when performing a relative measurement. Thus, for the measurement of the bb production cross section we determined not only the number of bb->J/psiX events, but also the number of prompt J/psi in the same sample. During the commissioning run of 2000, a sample of about 1 million di-electron triggered events was acquired. Most of the data was taken with a Carbon wire. For some runs a second wire of Titanium was inserted. The number of prompt J/psi in this data sample was determined by applying a fit to the spectrum of the invariant mass of the

  14. The CDFII Time-of-Flight detector and impact on beauty flavor tagging

    NASA Astrophysics Data System (ADS)

    Giagu, Stefano

    2003-06-01

    The new CDFII detector incorporates a Time-of-Flight detector (TOF), employing plastic scintillator bars and fine-mesh photomultipliers. Since August 2001 the TOF system has been fully instrumented and integrated into the CDFII data acquisition system. With a design goal of 100 ps resolution the TOF system will provide at least two standard deviations separation between K± and π± for momenta p < 1.6 GeV/ c, complementing low momentum particle identification by means of the specific ionization energy loss measured in the drift chamber. We describe the design of the TOF detector and discuss the current status of its calibration and initial performances. Finally we review the expected impact of the TOF detector in the flavor tagging of neutral Bs0 meson.

  15. Beauty for pedestrians toy models for CP violation and baryon asymmetry

    SciTech Connect

    Lipkin, H.J. ||

    1995-12-01

    Why are particles different from antiparticles? C and P Violation - 1956; CP Violation - 1964. Why so little new experimental information in thirty years? Where has all the antimatter gone? Toy models are presented showing: (1) How CPT and {Delta}I = 1/2 make life difficult in kaon physics by requiring equal K{sup {plus_minus}} total widths and also equal partial widths to many exclusive channels. (2) How to understand and get around CPT restrictions. (3) How CP asymmetries can occur in exclusive partial widths and still add up to equal total widths. (4) Sakharov`s 1966 scenario for how CP Violation + proton decay can explain baryon asymmetry (5) How B physics can help.

  16. Invited Review Small is beautiful: The analysis of nanogram-sized astromaterials

    NASA Astrophysics Data System (ADS)

    Zolensky, M. E.; Pieters, C.; Clark, B.; Papike, J. J.

    2000-01-01

    The capability of modern methods to characterize ultra-small samples is well established from analysis of interplanetary dust particles (IDPs), interstellar grains recovered from meteorites, and other materials requiring ultra-sensitive analytical capabilities. Powerful analytical techniques are available that require, under favorable circumstances, single particles of only a few nanograms for entire suites of fairly comprehensive characterizations. A returned sample of >1,000 particles with total mass of just one microgram permits comprehensive quantitative geochemical measurements that are impractical to carry out in situ by flight instruments. The main goal of this paper is to describe the state-of-the-art in microanalysis of astromaterials. Given that we can analyze fantastically small quantities of asteroids and comets, etc., we have to ask ourselves how representative are microscopic samples of bodies that measure a few to many km across? With the Galileo flybys of Gaspra and Ida, it is now recognized that even very small airless bodies have indeed developed a particulate regolith. Acquiring a sample of the bulk regolith, a simple sampling strategy, provides two critical pieces of information about the body. Regolith samples are excellent bulk samples since they normally contain all the key components of the local environment, albeit in particulate form. Furthermore, since this fine fraction dominates remote measurements, regolith samples also provide information about surface alteration processes and are a key link to remote sensing of other bodies. Studies indicate that a statistically significant number of nanogram-sized particles should be able to characterize the regolith of a primitive asteroid, although the presence of larger components within even primitive meteorites (e.g.. Murchison), e.g. chondrules, CAI, large crystal fragments, etc., points out the limitations of using data obtained from nanogram-sized samples to characterize entire primitive

  17. Polarization of intersecting particles

    NASA Astrophysics Data System (ADS)

    Paley, A. V.; Radchik, A. V.; Smith, G. B.; Vagov, A. V.

    1994-06-01

    An exact expression for the polarizability of intersecting circular cylinders has been derived covering all degrees of intersection and arbitrary complex dielectric constants for the particle material. This enables a comparison between the induced dipole moment on two particles of almost identical shape; a cardioid and a particular pair of overlapping cylinders. The absorption spectra in the small particle limit are extremely sensitive to the detailed shape of the surfaces near the point of intersection.

  18. The Sisyphus particle detector

    NASA Technical Reports Server (NTRS)

    Soberman, R. K.

    1974-01-01

    The particle measurement subsystem planned for the MJS 77 mission is described. Scientific objectives with respect to Saturn's rings are as follows: (1) measure particles outside the visible rings, including particulates orbiting in more distant rings and particles scattered out of visible rings, (2) measure meteoroid environment in vicinity of Saturn, and (3) develop an understanding of the dynamics of the rings with respect to their collisional interaction with the environment.

  19. Restoring particle phenomenology

    NASA Astrophysics Data System (ADS)

    Valente, Giovanni

    2015-08-01

    No-go theorems are known in the literature to the effect that, in relativistic quantum field theory, particle localizability in the strict sense violates relativistic causality. In order to account for particle phenomenology without particle ontology, Halvorson and Clifton (2002) proposed an approximate localization scheme. In a recent paper, Arageorgis and Stergiou (2013) proved a no-go result that suggests that, even within such a scheme, there would arise act-outcome correlations over the entire spacetime, thereby violating relativistic causality. Here, we show that this conclusion is untenable. In particular, we argue that one can recover particle phenomenology without having to give up relativistic causality.

  20. Bioactivation of particles

    DOEpatents

    Pinaud, Fabien; King, David; Weiss, Shimon

    2011-08-16

    Particles are bioactivated by attaching bioactivation peptides to the particle surface. The bioactivation peptides are peptide-based compounds that impart one or more biologically important functions to the particles. Each bioactivation peptide includes a molecular or surface recognition part that binds with the surface of the particle and one or more functional parts. The surface recognition part includes an amino-end and a carboxy-end and is composed of one or more hydrophobic spacers and one or more binding clusters. The functional part(s) is attached to the surface recognition part at the amino-end and/or said carboxy-end.