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Sample records for ben kogata kosoku

  1. Ben's Plastic Brain

    ERIC Educational Resources Information Center

    Kaplan, Susan L.

    2010-01-01

    This article shares a story of Ben who as a result of his premature birth, suffered a brain hemorrhage resulting in cerebral palsy, which affected his left side (left hemiparesis) and caused learning disabilities. Despite these challenges, he graduated from college and currently works doing information management for a local biotech start-up…

  2. Ben Franklin. [Lesson Plan].

    ERIC Educational Resources Information Center

    Discovery Communications, Inc., Bethesda, MD.

    Based on Benjamin Franklin's "Poor Richard's Almanac," this lesson plan presents activities designed to help students understand that Ben Franklin is known, among other things, for his wit and wisdom; that Franklin published an almanac for 25 years; and he scattered aphorisms throughout the almanac. The main activity in the lesson is for students…

  3. Obituary: Ben Hawkins Moore, 1921-2003

    NASA Astrophysics Data System (ADS)

    Moore, James F.

    2004-12-01

    Ben H. Moore, emeritus professor of physics, astronomy and earth sciences at St. Cloud State University, Minnesota, died 7 November 2003, in South Padre Island, Texas. Ben was born 18 March 1921, in Kansas City, Missouri, to Fraser D. and Cora R. (Hawkins) Moore. Though his parents provided a strong guiding influence on Ben's development, Ben's career was impacted most clearly by his work as a student and research assistant for Allen Basset (Ben's father-in-law) at Park College. This relationship turned Ben's early interest in chemistry and biology toward a focus on physics. Ben received his undergraduate degree from Park College where he graduated Phi Delta Kappa. He received a MS in physics from Kansas State University. He also did post-masters work at the University of Kansas, the University of Colorado, the University of Washington and Temple University. In addition to his work as a research assistant, Ben taught at Park College as well as Washington Kansas High School, Wyandotte High School, and Kansas City Kansas Junior College before moving to St. Cloud State University in 1960. He retired from this teaching position in May 1982 but remained involved in activities of his department, including some teaching, through most of his years in retirement. Ben's accomplishments were mainly centered on his teaching. His development of courses and his rapport with students consistently brought praise from both his colleagues and his students. Above all, his work involved innovative development of the curriculum in the sciences at St. Cloud State. Soon after his arrival at the university, Ben took over the fledgling field geology course and continued to shape this offering into a program in earth sciences. The popularity of his classes, which attracted both general students and a growing number of majors, finally enabled the university to establish an earth sciences department in the late 1960's and Ben was the first chair of that department. In the mid-1960's Ben took

  4. Obituary: Ben Hawkins Moore, 1921-2003

    NASA Astrophysics Data System (ADS)

    Moore, James F.

    2004-12-01

    Ben H. Moore, emeritus professor of physics, astronomy and earth sciences at St. Cloud State University, Minnesota, died 7 November 2003, in South Padre Island, Texas. Ben was born 18 March 1921, in Kansas City, Missouri, to Fraser D. and Cora R. (Hawkins) Moore. Though his parents provided a strong guiding influence on Ben's development, Ben's career was impacted most clearly by his work as a student and research assistant for Allen Basset (Ben's father-in-law) at Park College. This relationship turned Ben's early interest in chemistry and biology toward a focus on physics. Ben received his undergraduate degree from Park College where he graduated Phi Delta Kappa. He received a MS in physics from Kansas State University. He also did post-masters work at the University of Kansas, the University of Colorado, the University of Washington and Temple University. In addition to his work as a research assistant, Ben taught at Park College as well as Washington Kansas High School, Wyandotte High School, and Kansas City Kansas Junior College before moving to St. Cloud State University in 1960. He retired from this teaching position in May 1982 but remained involved in activities of his department, including some teaching, through most of his years in retirement. Ben's accomplishments were mainly centered on his teaching. His development of courses and his rapport with students consistently brought praise from both his colleagues and his students. Above all, his work involved innovative development of the curriculum in the sciences at St. Cloud State. Soon after his arrival at the university, Ben took over the fledgling field geology course and continued to shape this offering into a program in earth sciences. The popularity of his classes, which attracted both general students and a growing number of majors, finally enabled the university to establish an earth sciences department in the late 1960's and Ben was the first chair of that department. In the mid-1960's Ben took

  5. Deep-Sea Research Submarine 'Ben Franklin'

    NASA Technical Reports Server (NTRS)

    1969-01-01

    This is an aerial view of the deep-sea research submarine 'Ben Franklin' at dock. Named for American patriot and inventor Ben Franklin, who discovered the Gulf Steam, the 50-foot Ben Franklin was built between 1966 and 1968 in Switzerland for deep-ocean explorer Jacques Piccard and the Grumman Aircraft Engineering Corporation. The submersible made a famous 30-day drift dive off the East Coast of the United States and Canada in 1969 mapping the Gulf Stream's currents and sea life, and also made space exploration history by studying the behavior of aquanauts in a sealed, self-contained, self-sufficient capsule for NASA. On July 14, 1969, the Ben Franklin was towed to the high-velocity center of the Stream off the coast of Palm Beach, Florida. With a NASA observer on board, the sub descended to 1,000 feet off of Riviera Beach, Florida and drifted 1,400 miles north with the current for more than four weeks, reemerging near Maine. During the course of the dive, NASA conducted exhaustive analyses of virtually every aspect of onboard life. They measured sleep quality and patterns, sense of humor and behavioral shifts, physical reflexes, and the effects of a long-term routine on the crew. The submarine's record-shattering dive influenced the design of Apollo and Skylab missions and continued to guide NASA scientists as they devised future marned space-flight missions.

  6. Deep-Sea Submarine 'Ben Franklin'

    NASA Technical Reports Server (NTRS)

    1969-01-01

    The deep-sea submarine 'Ben Franklin' is being docked in the harbor. Named for American patriot and inventor Ben Franklin, who discovered the Gulf Steam, the 50-foot Ben Franklin was built between 1966 and 1968 in Switzerland for deep-ocean explorer Jacques Piccard and the Grumman Aircraft Engineering Corporation. The submersible made a famous 30-day drift dive off the East Coast of the United States and Canada in 1969 mapping the Gulf Stream's currents and sea life. It also made space exploration history by studying the behavior of aquanauts in a sealed, self-contained, self-sufficient capsule for NASA. On July 14, 1969, the Ben Franklin was towed to the high-velocity center of the Stream off the coast of Palm Beach, Florida. With a NASA observer on board, the sub descended to 1,000 feet off of Riviera Beach, Florida and drifted 1,400 miles north with the current for more than four weeks, reemerging near Maine. During the course of the dive, NASA conducted exhaustive analyses of virtually every aspect of onboard life. They measured sleep quality and patterns, sense of humor and behavioral shifts, physical reflexes, and the effect of a long-term routine on the crew. The submarine's record-shattering dive influenced the design of Apollo and Skylab missions and continued to guide NASA scientists as they devised future marned space-flight missions.

  7. David Ben-Gurion: A Creative Leader

    ERIC Educational Resources Information Center

    Rosemarin, Shoshana

    2014-01-01

    David Ben-Gurion (1886-1973), the first Prime Minister of Israel, is included in Pasternak's (2001) list of the nine most memorable leaders of the twentieth century. All of them are remembered for the reforms they initiated. Roosevelt (USA), Stalin (Russia), Castro (Cuba), and Thatcher (England) focused on social-economical changes, whereas…

  8. GENERAL VIEW OF FORMER F. & H. BENNING COMPLEX NORTH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    GENERAL VIEW OF FORMER F. & H. BENNING COMPLEX NORTH TOWARDS TENTHOUSE CREEK. THE SHELL MILL WAS LOCATED IN THE BUILDING IN THE FOREGROUND. THE SHUCKING AND PROCESSING WAS DONE IN THE REAR BUILDING. OYSTER BOATS DOCKED WHERE THE CRANES ARE CURRENTLY LOCATED. - F. & H. Benning Company, 1014 Benning Road, Galesville, Anne Arundel County, MD

  9. 27 CFR 9.118 - Ben Lomond Mountain.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Ben Lomond Mountain. 9.118... Lomond Mountain. (a) Name. The name of the viticultural area described in this section is “Ben Lomond Mountain.” (b) Approved maps. The appropriate maps for determining the boundaries of the Ben...

  10. 27 CFR 9.118 - Ben Lomond Mountain.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Ben Lomond Mountain. 9.118... Lomond Mountain. (a) Name. The name of the viticultural area described in this section is “Ben Lomond Mountain.” (b) Approved maps. The appropriate maps for determining the boundaries of the Ben...

  11. 27 CFR 9.118 - Ben Lomond Mountain.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Ben Lomond Mountain. 9.118... Lomond Mountain. (a) Name. The name of the viticultural area described in this section is “Ben Lomond Mountain.” (b) Approved maps. The appropriate maps for determining the boundaries of the Ben...

  12. 27 CFR 9.118 - Ben Lomond Mountain.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Ben Lomond Mountain. 9.118... Lomond Mountain. (a) Name. The name of the viticultural area described in this section is “Ben Lomond Mountain.” (b) Approved maps. The appropriate maps for determining the boundaries of the Ben...

  13. 27 CFR 9.118 - Ben Lomond Mountain.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Ben Lomond Mountain. 9.118... Lomond Mountain. (a) Name. The name of the viticultural area described in this section is “Ben Lomond Mountain.” (b) Approved maps. The appropriate maps for determining the boundaries of the Ben...

  14. 2006 National Caring Awards. Ben Carson, MD.

    PubMed

    2006-11-01

    Ben Carson is world famous, both for his work as a physician and as a humanitarian. Dr. Carson is the director of neurosurgery at Johns Hopkins University Hospital, who made history in 1987 when he successfully separated Siamese twins joined at the head. As important as this life-saving work is to him, what is more important is the philanthropic work that he and his wife, Candy, are doing to help underprivileged youth. PMID:17153676

  15. Genetic, Genomic and Epigenomic Studies of Balkan Endemic Nephropathy (Ben).

    PubMed

    Staneva, Rada G; Balabanski, L; Dimova, I; Rukova, B; Hadjidekova, S; Dimitrov, P; Simeonov, V; Ivanov, S; Vagarova, R; Malinov, M; Cukuranovic, R; Stefanovic, V; Polenakovic, M; Djonov, V; Galabov, A; Toncheva, D

    2015-01-01

    BEN is a primary, chronic tubulointerstitial nephritis characterized with chronic anemia, absence of edema, xantoderma, normal blood pressure and normal findings on the fundus oculi. The disease is distributed in restricted areas in Bulgaria, Romania, Croatia, Bosnia, Former Yugoslavia. Despite numerous studies on genetic and environmental factors and their possible involvement in BEN, its etiopathogenesis still remains elusive. Our recent study aim to elucidate the possible epigenetic component in BEN development. Whole genome DNA array methylation analysis was applied to compare the methylation profiles of male and female BEN patients from endemic regions in Bulgaria and Serbia and healthy controls. All three most prominent candidate genes with aberrations in the epigenetic profile discovered with this study are involved in the inflammatory/immune processes and oncogenesis. These data are in concordance with the reported pathological alterations in BEN. This research supports the role of epigenetic changes in BEN pathology. Exome sequencing of 22.000 genes with Illumina Nextera Exome Enrichment Kit revealed three mutant genes (CELA1, HSPG2, and KCNK5) in BEN patients which encode proteins involved in basement membrane/extracellular matrix and vascular tone, tightly connected to process of angiogenesis. We suggest that an abnormal process of angiogenesis plays a key role in the molecular pathogenesis of BEN. PMID:27442376

  16. Sifting through the Essential Fictions of Nonfiction: Contextualizing Ben Franklin.

    ERIC Educational Resources Information Center

    Smart, Karl

    One of the greatest myths or fictions of nonfiction is that it contains no fiction. Ben Franklin's flight from Boston to Philadelphia illustrates how changes occur in the retelling of the "facts" of a life. In his "Autobiography," Franklin writes that his friend, Collins, arranged for a ship's passage for Franklin by telling the ship's captain…

  17. BEN: A model to calculate the economic benefit of noncompliance. User's manual

    SciTech Connect

    Not Available

    1992-10-01

    The Agency developed the BEN computer model to calculate the economic benefit a violator derives from delaying or avoiding compliance with environmental statutes. In general, the Agency uses the BEN computer model to assist its own staff in developing settlement penalty figures. While the primary purpose of the BEN model is to calculate the economic benefit of noncompliance, the model may also be used to calculate the after tax net present value of a pollution prevention or mitigation project and to calculate 'cash outs' in Superfund cases. The document, the BEN User's Manual, contains all the formulas that make up the BEN computer model and is freely available to the public upon request.

  18. Registration of four soybean germplasm lines containing defoliating insect resistance QTLS from PI 229358 introgressed into 'Benning'

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Five soybean [Glycine max (L.) Merr.] germplasm lines were developed by the Georgia Agricultural Experiment Stations and released in 2005: G95-Ben335 (Reg. No. GP-332, PI 644042), G95-Ben1818 (Reg. No. GP-333, PI 644043), G95-Ben2403 (Reg. No. GP-334, PI 644044), G95-Ben2448 (Reg. No. GP-335, PI 644...

  19. 78 FR 63570 - Proposed Collection; Comment Request for Forms W-8BEN, W-8BEN-E, W-8ECI, W-8EXP, and W-8IMY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-24

    ... (sections 1471-1474) in T.D. 9610 (78 FR 5874). The general requirements of an FFI Agreement are described... Internal Revenue Service Proposed Collection; Comment Request for Forms W-8BEN, W-8BEN-E, W-8ECI, W-8EXP, and W-8IMY AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for...

  20. The Residence Teaching Practicum Internship at Ben-Gurion University of the Negev.

    ERIC Educational Resources Information Center

    Hoz, Ron; Peretz, Arna

    1996-01-01

    Describes an internship program at Israel's Ben-Gurion University, examining the role of practicums in teacher education, noting the work of mentors and interns, and discussing internship methods at selected North American universities. Suggestions are made to enhance the effectiveness of Ben-Gurion's Residence Practicum Internship. (SM)

  1. From Cherries Garcia to Child Care--The Story of Ben & Jerry's Children's Center.

    ERIC Educational Resources Information Center

    Neugebauer, Bonnie

    1990-01-01

    Jerry Greenfield, of Ben and Jerry's Ice Cream, and David Barash, director of human resources for the company, are interviewed about the Ben and Jerry's Children's Center. Objectives of management and employees regarding the center are discussed. Contributions of the company and its employees to the development of the center are noted. (SH)

  2. BEN:LINCS: A Community Model for the Pennsylvania Education Network.

    ERIC Educational Resources Information Center

    Garrigan, Scott

    BEN:LINCS (Bethlehem Education Network: A Local Instructional Network for Culture and Science), a Pennsylvania Testbed Project, attempts to demonstrate a sustainable model that supports network-based educational activities among schools, homes, libraries, museums, and local cultural organizations. The BEN:LINCS project envisioned a community-based…

  3. When autonomy kills: the case of Sami Mbarka Ben Garci.

    PubMed

    Garasic, Mirko; Foster, Charles

    2012-12-01

    Foucault suggested that foreigners and criminals are treated in a particularly unfavourable way by the law. We find arguable support for that proposition in the case of Sami Mbarka Ben Garci. He was a Tunisian Muslim prisoner, charged with rape, held in an Italian prison. He went on a hunger strike, protesting his innocence. He was not force-fed, and was allowed to die. Hunger strikers are commonly force fed. We ask why he was not, and although the reasons in his case are not clear, we suggest that many prisoners perceived as being 'undesirable' (in the sense of being foreigners, or facing particularly serious allegations) are allowed to die (the rhetoric being that their autonomy is being respected), while other prisoners' autonomy would be violated in order to ensure survival. We explore the European and some domestic jurisprudence surrounding force-feeding, and conclude that the law is applied in a worryingly inconsistent way. PMID:23447905

  4. [Academic heritage of Jiu huang ben cao (Materia Medica for Relief of Famines) in Japan].

    PubMed

    He, Huiling; Xiao, Yongzhi

    2014-11-01

    Jiu huang ben cao (Materia Medica for Relief of Famines) was the first monograph on famines herbal in the history of China, which creates a new research field of edible plants. Around the middle and late 17th century, Jiu huang ben cao was spread to Japan and aroused great attention of famous Japanese herbalists. Thus, all versions of different edition systems were circulated in Japan. Later, some famous Japanese scholar ssuccessively quoted texts of Jiu huang ben cao from the Nong zheng quan shu (Whole book on Agricultural Administration) spread in Japan, and block-printed it as an independent work. As a result, Jiu huang ben cao virtually circulated widely in Japan. PMID:25620360

  5. BenR, a XylS Homologue, Regulates Three Different Pathways of Aromatic Acid Degradation in Pseudomonas putida

    PubMed Central

    Cowles, Charles E.; Nichols, Nancy N.; Harwood, Caroline S.

    2000-01-01

    Pseudomonas putida converts benzoate to catechol using two enzymes that are encoded on the chromosome and whose expression is induced by benzoate. Benzoate also binds to the regulator XylS to induce expression of the TOL (toluene degradation) plasmid-encoded meta pathway operon for benzoate and methylbenzoate degradation. Finally, benzoate represses the ability of P. putida to transport 4-hydroxybenzoate (4-HBA) by preventing transcription of pcaK, the gene encoding the 4-HBA permease. Here we identified a gene, benR, as a regulator of benzoate, methylbenzoate, and 4-HBA degradation genes. A benR mutant isolated by random transposon mutagenesis was unable to grow on benzoate. The deduced amino acid sequence of BenR showed high similarity (62% identity) to the sequence of XylS, a member of the AraC family of regulators. An additional seven genes located adjacent to benR were inferred to be involved in benzoate degradation based on their deduced amino acid sequences. The benABC genes likely encode benzoate dioxygenase, and benD likely encodes 2-hydro-1,2-dihydroxybenzoate dehydrogenase. benK and benF were assigned functions as a benzoate permease and porin, respectively. The possible function of a final gene, benE, is not known. benR activated expression of a benA-lacZ reporter fusion in response to benzoate. It also activated expression of a meta cleavage operon promoter-lacZ fusion inserted in an E. coli chromosome. Third, benR was required for benzoate-mediated repression of pcaK-lacZ fusion expression. The benA promoter region contains a direct repeat sequence that matches the XylS binding site previously defined for the meta cleavage operon promoter. It is likely that BenR binds to the promoter region of chromosomal benzoate degradation genes and plasmid-encoded methylbenzoate degradation genes to activate gene expression in response to benzoate. The action of BenR in repressing 4-HBA uptake is probably indirect. PMID:11053377

  6. 40 CFR 721.1025 - Benzenamine, 4-chloro-2-methyl-; benzenamine, 4-chloro-2-methyl-, hydrochloride; and ben-zenamine...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Benzenamine, 4-chloro-2-methyl-; benzenamine, 4-chloro-2-methyl-, hydrochloride; and ben-zenamine, 2-chloro-6-methyl-. 721.1025 Section 721... Benzenamine, 4-chloro-2-methyl-; benzenamine, 4-chloro-2-methyl-, hydrochloride; and ben-zenamine,...

  7. 40 CFR 721.1025 - Benzenamine, 4-chloro-2-methyl-; benzenamine, 4-chloro-2-methyl-, hydrochloride; and ben-zenamine...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Benzenamine, 4-chloro-2-methyl-; benzenamine, 4-chloro-2-methyl-, hydrochloride; and ben-zenamine, 2-chloro-6-methyl-. 721.1025 Section 721... Benzenamine, 4-chloro-2-methyl-; benzenamine, 4-chloro-2-methyl-, hydrochloride; and ben-zenamine,...

  8. 76 FR 28005 - Draft Environmental Impact Statement (DEIS) for Training Land Expansion at Fort Benning, GA and AL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-13

    ...,800 acres of land in the vicinity of Fort Benning, Georgia (GA) and Alabama (AL) for military training..., comprised of approximately 182,000 contiguous acres, is located in west-central GA and east- central AL... Benning, GA and AL AGENCY: Department of the Army, DoD. ACTION: Notice of Availability (NOA). SUMMARY:...

  9. 78 FR 31593 - Aleris Recycling Bens Run, LLC, Including On-Site Leased Workers From Winans Extras Support...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration Aleris Recycling Bens Run, LLC, Including On-Site Leased Workers From... Recycling Bens Run, LLC, Friendly, West Virginia. The determination was issued on March 13, 2013....

  10. 78 FR 61385 - Aleris Recycling Bens Run, LLC, a Subsidiary of Aleris Corporation, Including On-Site Leased...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-03

    ... former workers of Aleris Recycling Bens Run, LLC, Friendly, West Virginia (subject firm). The Department's Notice of determination was published in the Federal Register on May 24, 2013 (78 FR 31593). The... Employment and Training Administration Aleris Recycling Bens Run, LLC, a Subsidiary of Aleris...

  11. 40 CFR 721.1150 - Substituted polyglycidyl ben-zena-mine.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Substituted polyglycidyl ben-zena-mine. 721.1150 Section 721.1150 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.1150...

  12. Dr. von Braun on top of the Deep-Sea Research Submarine 'Ben Franklin'

    NASA Technical Reports Server (NTRS)

    1969-01-01

    This photograph depicts Dr. von Braun (at right, showing his back) and other NASA officials surveying the deep-sea research submarine 'Ben Franklin.' Named for American patriot and inventor Ben Franklin, who discovered the Gulf Steam, the 50-foot Ben Franklin was built between 1966 and 1968 in Switzerland for deep-ocean explorer Jacques Piccard and the Grumman Aircraft Engineering Corporation. The submersible made a famous 30-day drift dive off the East Coast of the United States and Canada in 1969 mapping the Gulf Stream's currents and sea life, and also made space exploration history by studying the behavior of aquanauts in a sealed, self-contained, self-sufficient capsule for NASA. On July 14, 1969, the Ben Franklin was towed to the high-velocity center of the Stream off the coast of Palm Beach, Florida. With a NASA observer on board, the sub descended to 1,000 feet off of Riviera Beach, Florida and drifted 1,400 miles north with the current for more than four weeks, reemerging near Maine. During the course of the dive, NASA conducted exhaustive analyses of virtually every aspect of onboard life. They measured sleep quality and patterns, sense of humor and behavioral shifts, physical reflexes, and the effects of a long-term routine on the crew. The submarine's record-shattering dive influenced the design of Apollo and Skylab missions and continued to guide NASA scientists as they devised future marned space-flight missions.

  13. Dr. von Braun on Top of the Deep-Sea Research Submarine 'Ben Franklin'

    NASA Technical Reports Server (NTRS)

    1969-01-01

    This photograph depicts Dr. von Braun (fourth from far right) and other NASA officials surveying the deep-sea research submarine 'Ben Franklin.' Named for American patriot and inventor Ben Franklin, who discovered the Gulf Steam, the 50-foot Ben Franklin was built between 1966 and 1968 in Switzerland for deep-ocean explorer Jacques Piccard and the Grumman Aircraft Engineering Corporation. The submersible made a famous 30-day drift dive off the East Coast of the United States and Canada in 1969 mapping the Gulf Stream's currents and sea life, and also made space exploration history by studying the behavior of aquanauts in a sealed, self-contained, self-sufficient capsule for NASA. On July 14, 1969, the Ben Franklin was towed to the high-velocity center of the Stream off the coast of Palm Beach, Florida. With a NASA observer on board, the sub descended to 1,000 feet off of Riviera Beach, Florida and drifted 1,400 miles north with the current for more than four weeks, reemerging near Maine. During the course of the dive, NASA conducted exhaustive analyses of virtually every aspect of onboard life. They measured sleep quality and patterns, sense of humor and behavioral shifts, physical reflexes, and the effects of a long-term routine on the crew. The submarine's record-shattering dive influenced the design of Apollo and Skylab missions and continued to guide NASA scientists as they devised future marned space-flight missions.

  14. Interior View of the Deep-Sea Research Submarine 'Ben Franklin'

    NASA Technical Reports Server (NTRS)

    1969-01-01

    This is an interior view of the living quarters of the deep-sea research submarine 'Ben Franklin.' Named for American patriot and inventor Ben Franklin, who discovered the Gulf Steam, the 50-foot Ben Franklin was built between 1966 and 1968 in Switzerland for deep- ocean explorer Jacques Piccard and the Grumman Aircraft Engineering Corporation. The submersible made a famous 30-day drift dive off the East Coast of the United States and Canada in 1969 mapping the Gulf Stream's currents and sea life, and also made space exploration history by studying the behavior of aquanauts in a sealed, self-contained, self-sufficient capsule for NASA. On July 14, 1969, the Ben Franklin was towed to the high-velocity center of the Stream off the coast of Palm Beach, Florida. With a NASA observer on board, the sub descended to 1,000 feet off of Riviera Beach, Florida and drifted 1,400 miles north with the current for more than four weeks, reemerging near Maine. During the course of the dive, NASA conducted exhaustive analyses of virtually every aspect of onboard life. They measured sleep quality and patterns, sense of humor and behavioral shifts, physical reflexes, and the effect of a long-term routine on the crew. The submarine's record-shattering dive influenced the design of Apollo and Skylab missions and continued to guide NASA scientists as they devised future marned space-flight missions.

  15. Systematic revision of the mealybug genus Delottococcus Cox & Ben-Dov (Hemiptera: Pseudococcidae)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A systematic revision of the mealybug genus Delottococcus Cox & Ben-Dov is presented. Nine species are treated, including D. millari which is described as new. The 8 previously described species are: Delottococcus aberiae (De Lotto), D. confusus (De Lotto), D. elisabethae (Brain), D. euphorbiae (E...

  16. 75 FR 5511 - Safety Zone; AICW Closure Safety Zone for Ben Sawyer Bridge Replacement Project, Sullivan's...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-03

    ... bridge replacement operations. Discussion of Rule The Coast Guard is establishing a temporary safety zone... Instruction. This rule establishes a temporary safety zone to protect the public from bridge replacement...; AICW Closure Safety Zone for Ben Sawyer Bridge Replacement Project, Sullivan's Island, SC. (a)...

  17. Deep-Sea Research Submarine 'Ben Franklin' at the East Coast of the United States

    NASA Technical Reports Server (NTRS)

    1969-01-01

    In this photograph, the deep-sea Research Submarine 'Ben Franklin' drifts off the East Coast of the United States (U.S.) prior to submerging into the ocean. Named for American patriot and inventor Ben Franklin, who discovered the Gulf Steam, the 50-foot Ben Franklin was built between 1966 and 1968 in Switzerland for deep-ocean explorer Jacques Piccard and the Grumman Aircraft Engineering Corporation. The submersible made a famous 30-day drift dive off the East Coast of the United States and Canada in 1969 mapping the Gulf Stream's currents and sea life, and also made space exploration history by studying the behavior of aquanauts in a sealed, self-contained, self-sufficient capsule for NASA. On July 14, 1969, the Ben Franklin was towed to the high-velocity center of the Stream off the coast of Palm Beach, Florida. With a NASA observer on board, the sub descended to 1,000 feet off of Riviera Beach, Florida and drifted 1,400 miles north with the current for more than four weeks, reemerging near Maine. During the course of the dive, NASA conducted exhaustive analyses of virtually every aspect of onboard life. They measured sleep quality and patterns, sense of humor and behavioral shifts, physical reflexes, and the effects of a long-term routine on the crew. The submarine's record-shattering dive influenced the design of Apollo and Skylab missions and continued to guide NASA scientists as they devised future marned space-flight missions.

  18. Electronic Theses at Ben-Gurion University: Israel as Part of the Worldwide ETD Movement

    ERIC Educational Resources Information Center

    Asner, Haya; Polani, Tsviya

    2008-01-01

    This article discusses the electronic thesis and dissertation project at the Ben-Gurion University of the Negev, Be'er Sheva, Israel. It describes the status of the ETD movement in Israel as part of the worldwide spread of ETDs as reported in the literature. It also examines openness to ETDs by faculty and by publisher discipline. (Contains 6…

  19. Military vehicle trafficking impacts vegetation and soil bulk density at Fort Benning, Georgia

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Potential increases in wind erosion that might be brought about by military vehicles travelling off-road during training are of concern to the United States military. Field studies were conducted in the summer of 2012 at Fort Benning, Georgia. The objective of the experiment was to assess the traffi...

  20. Military vehicle trafficking impacts on vegetation and soil bulk density at Fort Benning, Georgia

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Potential increases in wind erosion that might be brought about by military vehicles travelling on off-road sites during training are of concern to the Military establishment. Field studies were conducted in the summer of 2012 at Fort Benning, Georgia. The objective of the experiment was to assess t...

  1. Education, Life Expectancy and Family Bargaining: The Ben-Porath Effect Revisited

    ERIC Educational Resources Information Center

    Leker, Laura; Ponthiere, Gregory

    2015-01-01

    Following Ben-Porath [1967. "The Production of Human Capital and the Life-Cycle of Earnings." "Journal of Political Economy" 75 (3): 352-365], the influence of life expectancy on education and on human capital has attracted much attention among growth theorists. Whereas existing growth models rely on an education decision made…

  2. Ant community composition across a gradient of disturbed military landscapes at Fort Benning, Georgia

    USGS Publications Warehouse

    Graham, J.H.; Krzysik, A.J.; Kovacic, D.A.; Duda, J.J.; Freeman, D.C.; Emlen, J.M.; Zak, J.C.; Long, W.R.; Wallace, M.P.; Chamberlin-Graham, C.; Nutter, J.P.; Balbach, H.E.

    2008-01-01

    Military training, soil texture, and ground cover influence ant communities at Fort Benning, a military installation in west-central Georgia. We sampled 81,237 ground-dwelling ants (47 species in 20 genera) with pitfall traps at 40 sites on a continuum from nearly pristine forest to highly disturbed training areas. We also measured 15 environmental variables related to vegetation and soil. Sites disturbed by military training had fewer trees, less canopy cover, more bare ground, and more compact soils with shallower A-horizons than comparable undisturbed sites. Pheidole bicarinata, Dorymyrmex smithi, and Pogonomyrmex badius dominated the most highly disturbed sites. Competitively submissive myrmicines, such as Aphaenogaster and Crematogaster, and formicines, such as Camponotus and Formica, were abundant in the undisturbed sites. Solenopsis invicta occurred in all but the least disturbed sites. Ant community composition was a useful indicator of disturbance at Fort Benning.

  3. Evaluation of pest vulnerability of 'Benning' soybean value added and insect resistant near isogenic lines.

    PubMed

    Samuel-Foo, Michelle; All, John N; Boerma, H Roger

    2013-04-01

    Crop enhancement with value added traits may affect vulnerability to insects, and evaluating the susceptibility levels of the various value added traits in elite germplasm would aid in developing integrated pest management strategies. During 2007-2008, five 'Benning' soybean (Glycine max (L.) Merr) lines with different value added nutritional traits and four insect resistant quantitative trait loci (QTL) lines were evaluated in an effort to determine their pest vulnerability under artificial and natural insect pest populations. The lines showed variable susceptibility to lepidopterous insect pests classified as defoliators and stem feeders in replicated greenhouse and field tests. The study was carried out in Athens and Midville, GA. The green cloverworm (Hypena scabra (F.)) was the most common lepidopteran defoliator occurring in the fields. Other caterpillar pests found included the soybean looper (Pseudoplusia includens (Walker)), the bollworm (Helicoverpa zea (Boddie)), and the velvetbean caterpillar (Anticarsia gemmatalis (Hübner)). Data indicated that there was no significantly increased pest susceptibility among the value added cultivars with improved nutritional qualities, with the insect resistant quantitative trait loci lines Benning M and Benning MGH consistently being less susceptible to lepidopterous (Noctuidae) leaf injury. PMID:23786071

  4. Land Cover Differences in Soil Carbon and Nitrogen at Fort Benning, Georgia

    SciTech Connect

    Garten Jr., C.T.

    2004-02-09

    Land cover characterization might help land managers assess the impacts of management practices and land cover change on attributes linked to the maintenance and/or recovery of soil quality. However, connections between land cover and measures of soil quality are not well established. The objective of this limited investigation was to examine differences in soil carbon and nitrogen among various land cover types at Fort Benning, Georgia. Forty-one sampling sites were classified into five major land cover types: deciduous forest, mixed forest, evergreen forest or plantation, transitional herbaceous vegetation, and barren land. Key measures of soil quality (including mineral soil density, nitrogen availability, soil carbon and nitrogen stocks, as well as properties and chemistry of the O-horizon) were significantly different among the five land covers. In general, barren land had the poorest soil quality. Barren land, created through disturbance by tracked vehicles and/or erosion, had significantly greater soil density and a substantial loss of carbon and nitrogen relative to soils at less disturbed sites. We estimate that recovery of soil carbon under barren land at Fort Benning to current day levels under transitional vegetation or forests would require about 60 years following reestablishment of vegetation. Maps of soil carbon and nitrogen were produced for Fort Benning based on a 1999 land cover map and field measurements of soil carbon and nitrogen stocks under different land cover categories.

  5. Structure of a putative BenF-like porin from Pseudomonas fluorescens Pf-5 at 2.6 A resolution

    SciTech Connect

    Sampathkumar, P.; Swaminathan, S.; Lu, F.; Zhao, X.; Li, Z.; Gilmore, J.; Bain, K.; Rutter, M. E.; Gheyi, T.; Schwinn, D.; Bonanno, J. B.; Pieper, U.; Fajardo, J. E.; Fiser, A.; Almo, S. C.; Chance, M. R.; Baker, D.; Atwell, S.; Thompson, D. A.; Emtage, J. S.; Wasserman, S. R.; Sali, A.; Sauder, J. M.; Burley, S. K.

    2010-11-01

    Gram-negative bacteria typically overcome poor permeability of outer membranes through general porins like OmpF and OmpC, which form water-filled transmembrane pores permitting diffusion of hydrophilic molecules with no particular selectivity. Many bacteria lacking such general porins use substrate-specific porins to overcome growth-limiting conditions and facilitate selective transport of metabolites. Exclusive reliance on substrate-specific porins yields lower membrane permeability to small molecules (<600 Da) versus that seen for Escherichia coli. In Pseudomonads, transit of most small molecules across the cell membrane is thought to be mediated by substrate-specific channels of the OprD superfamily. This property explains, at least in part, the high incidence of Pseudomonas aeruginosa antibiotic resistance. High-throughput DNA sequencing of the P. aeruginosa chromosome revealed the presence of 19 genes encoding structurally related, substrate-specific porins (with 30-45% pairwise amino acid sequence identity) that mediate transmembrane passage of small, water-soluble compounds. The OprD superfamily encompasses the eponymous OprD subfamily, which includes 9 P. aeruginosa proteins that convey basic amino acids and carbapenem antibiotics, and the OpdK subfamily, which includes 11 P. aeruginosa proteins that convey aromatic acids and other small aromatic compounds. Genome sequencing of other gram-negative bacteria has revealed additional members of the OprD and OpdK subfamilies in various organisms, including other pseudomonads. Among the many bacteria in which OprD superfamily members have been identified are P. putida, P. fluorescens Pf-5, P. syringae, and Azotobacter vinelandii, all of which share closely related genes that encode the so-called BenF-like porins. In P. putida, benF is part of an operon involved in benzoate catabolism regulated by benR. Within this operon, benK, benE, and benF genes have been suggested to contribute toward either influx or efflux

  6. Inducer responses of BenM, a LysR-type transcriptional regulator from Acinetobacter baylyi ADP1

    SciTech Connect

    Craven, Sarah H.; Ezezika, Obidimma C.; Haddad, Sandra; Hall, Ruth A.; Momany, Cory; Neidle, Ellen L.; Georgia

    2009-06-25

    BenM and CatM control transcription of a complex regulon for aromatic compound degradation. These Acinetobacter baylyi paralogues belong to the largest family of prokaryotic transcriptional regulators, the LysR-type proteins. Whereas BenM activates transcription synergistically in response to two effectors, benzoate and cis,cis-muconate, CatM responds only to cis,cis-muconate. Here, site-directed mutagenesis was used to determine the physiological significance of an unexpected benzoate-binding pocket in BenM discovered during structural studies. Residues in BenM were changed to match those of CatM in this hydrophobic pocket. Two BenM residues, R160 and Y293, were found to mediate the response to benzoate. Additionally, alteration of these residues caused benzoate to inhibit activation by cis,cis-muconate, positioned in a separate primary effector-binding site of BenM. The location of the primary site, in an interdomain cleft, is conserved in diverse LysR-type regulators. To improve understanding of this important family, additional regulatory mutants were analysed. The atomic-level structures were characterized of the effector-binding domains of variants that do not require inducers for activation, CatM(R156H) and BenM(R156H,T157S). These structures clearly resemble those of the wild-type proteins in their activated muconate-bound complexes. Amino acid replacements that enable activation without effectors reside at protein interfaces that may impact transcription through effects on oligomerization.

  7. The BEN domain is a novel sequence-specific DNA-binding domain conserved in neural transcriptional repressors

    PubMed Central

    Dai, Qi; Ren, Aiming; Westholm, Jakub O.; Serganov, Artem A.; Patel, Dinshaw J.; Lai, Eric C.

    2013-01-01

    We recently reported that Drosophila Insensitive (Insv) promotes sensory organ development and has activity as a nuclear corepressor for the Notch transcription factor Suppressor of Hairless [Su(H)]. Insv lacks domains of known biochemical function but contains a single BEN domain (i.e., a “BEN-solo” protein). Our chromatin immunoprecipitation (ChIP) sequencing (ChIP-seq) analysis confirmed binding of Insensitive to Su(H) target genes in the Enhancer of split gene complex [E(spl)-C]; however, de novo motif analysis revealed a novel site strongly enriched in Insv peaks (TCYAATHRGAA). We validate binding of endogenous Insv to genomic regions bearing such sites, whose associated genes are enriched for neural functions and are functionally repressed by Insv. Unexpectedly, we found that the Insv BEN domain binds specifically to this sequence motif and that Insv directly regulates transcription via this motif. We determined the crystal structure of the BEN–DNA target complex, revealing homodimeric binding of the BEN domain and extensive nucleotide contacts via α helices and a C-terminal loop. Point mutations in key DNA-contacting residues severely impair DNA binding in vitro and capacity for transcriptional regulation in vivo. We further demonstrate DNA-binding and repression activities by the mammalian neural BEN-solo protein BEND5. Altogether, we define novel DNA-binding activity in a conserved family of transcriptional repressors, opening a molecular window on this extensive gene family. PMID:23468431

  8. Territoriality of feral pigs in a highly persecuted population on Fort Benning, Georgia

    USGS Publications Warehouse

    Sparklin, B.D.; Mitchell, M.S.; Hanson, L.B.; Jolley, D.B.; Ditchkoff, S.S.

    2009-01-01

    We examined home range behavior of female feral pigs (Sus scrofa) in a heavily hunted population on Fort Benning Military Reservation in west-central Georgia, USA. We used Global Positioning System location data from 24 individuals representing 18 sounders (i.e., F social groups) combined with markrecapture and camera-trap data to evaluate evidence of territorial behavior at the individual and sounder levels. Through a manipulative experiment, we examined evidence for an inverse relationship between population density and home range size that would be expected for territorial animals. Pigs from the same sounder had extensive home range overlap and did not have exclusive core areas. Sounders had nearly exclusive home ranges and had completely exclusive core areas, suggesting that female feral pigs on Fort Benning were territorial at the sounder level but not at the individual level. Lethal removal maintained stable densities of pigs in our treatment area, whereas density increased in our control area; territory size in the 2 areas was weakly and inversely related to density of pigs. Territorial behavior in feral pigs could influence population density by limiting access to reproductive space. Removal strategies that 1) match distribution of removal efforts to distribution of territories, 2) remove entire sounders instead of individuals, and 3) focus efforts where high-quality food resources strongly influence territorial behaviors may be best for long-term control of feral pigs.

  9. Modeling soil quality thresholds to ecosystem recovery at Fort Benning, GA, USA

    SciTech Connect

    Garten Jr, Charles T; Ashwood, Tom L

    2004-12-01

    The objective of this research was to use a simple model of soil carbon (C) and nitrogen (N) dynamics to predict nutrient thresholds to ecosystem recovery on degraded soils at Fort Benning, Georgia, in the southeastern USA. Artillery, wheeled, and tracked vehicle training at military installations can produce soil disturbance and potentially create barren, degraded soils. Ecosystem reclamation is an important component of natural resource management at military installations. Four factors were important to the development of thresholds to recovery of aboveground biomass on degraded soils: (1) initial amounts of aboveground biomass, (2) initial soil C stocks (i.e., soil quality), (3) relative recovery rates of biomass, and (4) soil sand content. Forests and old fields on soils with varying sand content had different predicted thresholds for ecosystem recovery. Soil C stocks at barren sites on Fort Benning were generally below predicted thresholds to 100% recovery of desired future ecosystem conditions defined on the basis of aboveground biomass. Predicted thresholds to ecosystem recovery were less on soils with more than 70% sand content. The lower thresholds for old field and forest recovery on more sandy soils were apparently due to higher relative rates of net soil N mineralization. Calculations with the model indicated that a combination of desired future conditions, initial levels of soil quality (defined by soil C stocks), and the rate of biomass accumulation determine the predicted success of ecosystem recovery on disturbed soils.

  10. Development and Demonstration of a Hybrid Modeling Capability Within the Fort Benning HSPF Watershed Model: Refinement of Unpaved Road Simulation Using Wepp:Road

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A four-year project funded by the Strategic Environmental Research and Development Program (SERDP) is in progress to develop a comprehensive watershed management model (using EPA’s BASINS modeling system and HSPF watershed model) for Fort Benning, Georgia. The resulting Fort Benning Watershed Model ...

  11. [„Kids’ Skills” by Ben Furman – Description and Research Review].

    PubMed

    Perband, Anke; Haupts, Nadja; Rogner, Josef

    2016-01-01

    The article describes the programme „Kids’ Skills“ by the Finnish psychiatrist Ben Furman. „Kids’ Skills“ was developed to address behavioural issues in children. It is based on the assumption that children’s behavioural problems should not be pathologized, but can instead be corrected by learning a corresponding skill. The programme is characterised by its focus on strengths and its humorous and playful approach. The 15 steps of “Kids’ Skills” are intended to identify the specific skill, help generate a learning process and continue motivating the child. The authors describe the steps of the programme using a case study. They also address the limited number of existing studies, which have included a telephone and an online survey of practitioners using the programme, as well as case studies. The results of these studies are discussed with regard to their basis in evidence and practical relevance. Continuing research is recommended and possible implementations are suggested. PMID:26947531

  12. A study of the macro-environment at BenCat in southern Vietnam

    NASA Astrophysics Data System (ADS)

    Verma, R. P.; Chau, L. H.; Thin, C. X.

    1992-12-01

    Based on the meteorological data over a period of 4 years (1980-3), the macro-environment of BenCat Farm situated in the southern part of Vietnam (27 m above mean sea-level, 11° N and 106° E) was categorized as a “monsoon tropical climate”, due to heavy rainfall (annual mean 2028.96 mm) and about 32% wet days (annual mean 116.52 days) together with high air temperature (annual mean daily temperature 28.58, max. 32.33 and min 24.85° C). April was the hottest (monthly mean >35°C) and January the coldest month (monthly mean <22° C) of the year. The maximum number of wet days were during September and October (mean 18 days.month), whereas the minimum number of wet days were during January and February (mean <1 day/month). The months of December and January at Ben-Cat buffalo farm were categorized as the “comfortable (moderate-Dry) period” as the mean daily temperature was <27° C, while the remaining 10 months of the Calender year (February-November) were categorized as the “hot period” (mean daily temperature >27° C). On the basis of rainfall and the number of wet days, the hot period was further subdivided into a “hot-dry period” (February-April, mean of 1.67 wet days/month and mean rainfall 19.43 mm/month) and a “hot-humid period” (May-November, mean of 15.57 wet days/month and mean rainfall 276.28 mm/month).

  13. 33 CFR 334.750 - Ben's Lake, a tributary of Choctawhatchee Bay, Fla., at Eglin Air Force Base; restricted area.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Choctawhatchee Bay, Fla., at Eglin Air Force Base; restricted area. 334.750 Section 334.750 Navigation and... RESTRICTED AREA REGULATIONS § 334.750 Ben's Lake, a tributary of Choctawhatchee Bay, Fla., at Eglin Air Force..., without the permission of the Commander, Eglin Air Force Base, Florida, or his authorized...

  14. 33 CFR 334.750 - Ben's Lake, a tributary of Choctawhatchee Bay, Fla., at Eglin Air Force Base; restricted area.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Choctawhatchee Bay, Fla., at Eglin Air Force Base; restricted area. 334.750 Section 334.750 Navigation and... RESTRICTED AREA REGULATIONS § 334.750 Ben's Lake, a tributary of Choctawhatchee Bay, Fla., at Eglin Air Force..., without the permission of the Commander, Eglin Air Force Base, Florida, or his authorized...

  15. [Book Review] The Dead Sea, the lake and its setting, edited by T. Niemi, Z. Ben-Avraham, J. Gat

    USGS Publications Warehouse

    ten Brink, Uri

    1998-01-01

    Review of The Dead Sea, the Lake and its Setting. Tina M. Niemi, Zvi Ben-Avraham, and Joel R. Gat (Editors). Oxford Monographs on Geology and Geophysics No. 36. Oxford University Press, N.Y. 286 pp. ISBN 0-19-508703-8, 1997. $75.

  16. Development of the Fort Benning Dependents' Schools Multi-Ethnic Curriculum Guide and Human Relations Workshop; Post-Workshop Evaluation.

    ERIC Educational Resources Information Center

    Fort Benning Dependents' Schools, GA.

    Since the Korean War and the integration of all ethnic groups in the Army, the Fort Benning Dependents' Schools have served the educational needs of the sons and daughters of culturally different families living on the post. A letter from the Department of the Army on April 22, 1970 expressed the desires of the department to make greater efforts…

  17. Common and distinct DNA-binding and regulatory activities of the BEN-solo transcription factor family

    PubMed Central

    Dai, Qi; Ren, Aiming; Westholm, Jakub O.; Duan, Hong; Patel, Dinshaw J.

    2015-01-01

    Recently, the BEN (BANP, E5R, and NAC1) domain was recognized as a new class of conserved DNA-binding domain. The fly genome encodes three proteins that bear only a single BEN domain (“BEN-solo” factors); namely, Insensitive (Insv), Bsg25A (Elba1), and CG9883 (Elba2). Insv homodimers preferentially bind CCAATTGG palindromes throughout the genome to mediate transcriptional repression, whereas Bsg25A and Elba2 heterotrimerize with their obligate adaptor, Elba3 (i.e., the ELBA complex), to recognize a CCAATAAG motif in the Fab-7 insulator. While these data suggest distinct DNA-binding properties of BEN-solo proteins, we performed reporter assays that indicate that both Bsg25A and Elba2 can individually recognize Insv consensus sites efficiently. We confirmed this by solving the structure of Bsg25A complexed to the Insv site, which showed that key aspects of the BEN:DNA recognition strategy are similar between these proteins. We next show that both Insv and ELBA proteins are competent to mediate transcriptional repression via Insv consensus sequences but that the ELBA complex appears to be selective for the ELBA site. Reciprocally, genome-wide analysis reveals that Insv exhibits significant cobinding to class I insulator elements, indicating that it may also contribute to insulator function. Indeed, we observed abundant Insv binding within the Hox complexes with substantial overlaps with class I insulators, many of which bear Insv consensus sites. Moreover, Insv coimmunoprecipitates with the class I insulator factor CP190. Finally, we observed that Insv harbors exclusive activity among fly BEN-solo factors with respect to regulation of Notch-mediated cell fate choices in the peripheral nervous system. This in vivo activity is recapitulated by BEND6, a mammalian BEN-solo factor that conserves the Notch corepressor function of Insv but not its capacity to bind Insv consensus sites. Altogether, our data define an array of common and distinct biochemical and functional

  18. Common and distinct DNA-binding and regulatory activities of the BEN-solo transcription factor family.

    PubMed

    Dai, Qi; Ren, Aiming; Westholm, Jakub O; Duan, Hong; Patel, Dinshaw J; Lai, Eric C

    2015-01-01

    Recently, the BEN (BANP, E5R, and NAC1) domain was recognized as a new class of conserved DNA-binding domain. The fly genome encodes three proteins that bear only a single BEN domain ("BEN-solo" factors); namely, Insensitive (Insv), Bsg25A (Elba1), and CG9883 (Elba2). Insv homodimers preferentially bind CCAATTGG palindromes throughout the genome to mediate transcriptional repression, whereas Bsg25A and Elba2 heterotrimerize with their obligate adaptor, Elba3 (i.e., the ELBA complex), to recognize a CCAATAAG motif in the Fab-7 insulator. While these data suggest distinct DNA-binding properties of BEN-solo proteins, we performed reporter assays that indicate that both Bsg25A and Elba2 can individually recognize Insv consensus sites efficiently. We confirmed this by solving the structure of Bsg25A complexed to the Insv site, which showed that key aspects of the BEN:DNA recognition strategy are similar between these proteins. We next show that both Insv and ELBA proteins are competent to mediate transcriptional repression via Insv consensus sequences but that the ELBA complex appears to be selective for the ELBA site. Reciprocally, genome-wide analysis reveals that Insv exhibits significant cobinding to class I insulator elements, indicating that it may also contribute to insulator function. Indeed, we observed abundant Insv binding within the Hox complexes with substantial overlaps with class I insulators, many of which bear Insv consensus sites. Moreover, Insv coimmunoprecipitates with the class I insulator factor CP190. Finally, we observed that Insv harbors exclusive activity among fly BEN-solo factors with respect to regulation of Notch-mediated cell fate choices in the peripheral nervous system. This in vivo activity is recapitulated by BEND6, a mammalian BEN-solo factor that conserves the Notch corepressor function of Insv but not its capacity to bind Insv consensus sites. Altogether, our data define an array of common and distinct biochemical and functional

  19. Full-Length Structures of BenM and Two Variants Reveal Different Oligomerization Schemes for LysR-Type Transcriptional Regulators

    SciTech Connect

    Ruangprasert, Ajchareeya; Craven, Sarah H.; Neidle, Ellen L.; Momany, Cory

    2010-11-30

    BenM, a LysR-type transcriptional regulator (LTTR) from the bacterium Acinetobacter baylyi, responds synergistically to benzoate and cis,cis-muconate. With these effectors, BenM activates gene expression during benzoate consumption. Without effectors, BenM represses transcription. Here, X-ray crystallography was used to determine the full-length structures of BenM and two variants that activate transcription without benzoate or cis,cis-muconate: BenM(R156H) and BenM(E226K). Previous studies indicate that these regulators function as tetramers. Here, interconnections between subunits in the crystals prevented the formation of a closed oligomer and highlighted the inherent flexibility of this multidomain regulator. Nevertheless, analysis of subunit interfaces suggested the functional significance of key interactions. The structures of BenM and its variants were nearly identical, implying that transcriptional differences rely on factors beyond major conformational changes defined solely by sequence. Comparisons of BenM with other LTTRs, including unpublished structures in the Protein Data Bank, revealed extensive variation in the relative orientations of DNA-binding domains (DBDs) and effector-binding domains (EBDs). To form dimers, different LTTRs used similar interfaces between two EBDs, each containing two subdomains: EBD-I and EBD-II. Surprisingly, the dimers used three substantially different schemes to form higher-order oligomers. In one scheme used by BenM, oligomer assembly involved contacts between the EBD-II regions and the DBD regions of adjacent subunits. In another scheme, there were no contacts between the EBDs; only the DBDs were involved in tetramer formation. In the third scheme, the oligomer interface involved DBD and EBD-I/EBD-II contacts. These diverse schemes demonstrate novel variation in the oligomeric structures of individual LTTRs within this large and important family.

  20. Effects of Heavy, Tracked-Vehicle Disturbance on Forest Soil Properties at Fort Benning, Georgia

    SciTech Connect

    Garten, C.T.,JR.

    2004-05-20

    The purpose of this report is to describe the effects of heavy, tracked-vehicle disturbance on various measures of soil quality in training compartment K-11 at Fort Benning, Georgia. Predisturbance soil sampling in April and October of 2002 indicated statistically significant differences in soil properties between upland and riparian sites. Soil density was less at riparian sites, but riparian soils had significantly greater C and N concentrations and stocks than upland soils. Most of the C stock in riparian soils was associated with mineral-associated organic matter (i.e., the silt + clay fraction physically separated from whole mineral soil). Topographic differences in soil N availability were highly dependent on the time of sampling. Riparian soils had higher concentrations of extractable inorganic N than upland soils and also exhibited significantly greater soil N availability during the spring sampling. The disturbance experiment was performed in May 2003 by driving a D7 bulldozer through the mixed pine/hardwood forest. Post-disturbance sampling was limited to upland sites because training with heavy, tracked vehicles at Fort Benning is generally confined to upland soils. Soil sampling approximately one month after the experiment indicated that effects of the bulldozer were limited primarily to the forest floor (O-horizon) and the surface (0-10 cm) mineral soil. O-horizon dry mass and C stocks were significantly reduced, relative to undisturbed sites, and there was an indication of reduced mineral soil C stocks in the disturbance zone. Differences in the surface (0-10 cm) mineral soil also indicated a significant increase in soil density as a result of disturbance by the bulldozer. Although there was some tendency for greater soil N availability in disturbed soils, the changes were not significantly different from undisturbed controls. It is expected that repeated soil disturbance over time, which will normally occur in a military training area, would simply

  1. Modeling Soil Quality Thresholds to Ecosystem Recovery at Fort Benning, Georgia, USA

    SciTech Connect

    Garten Jr., C.T.

    2004-03-08

    The objective of this research was to use a simple model of soil C and N dynamics to predict nutrient thresholds to ecosystem recovery on degraded soils at Fort Benning, Georgia, in the southeastern USA. The model calculates aboveground and belowground biomass, soil C inputs and dynamics, soil N stocks and availability, and plant N requirements. A threshold is crossed when predicted soil N supplies fall short of predicted N required to sustain biomass accrual at a specified recovery rate. Four factors were important to development of thresholds to recovery: (1) initial amounts of aboveground biomass, (2) initial soil C stocks (i.e., soil quality), (3) relative recovery rates of biomass, and (4) soil sand content. Thresholds to ecosystem recovery predicted by the model should not be interpreted independent of a specified recovery rate. Initial soil C stocks influenced the predicted patterns of recovery by both old field and forest ecosystems. Forests and old fields on soils with varying sand content had different predicted thresholds to recovery. Soil C stocks at barren sites on Fort Benning generally lie below predicted thresholds to 100% recovery of desired future ecosystem conditions defined on the basis of aboveground biomass (18000 versus 360 g m{sup -2} for forests and old fields, respectively). Calculations with the model indicated that reestablishment of vegetation on barren sites to a level below the desired future condition is possible at recovery rates used in the model, but the time to 100% recovery of desired future conditions, without crossing a nutrient threshold, is prolonged by a reduced rate of forest growth. Predicted thresholds to ecosystem recovery were less on soils with more than 70% sand content. The lower thresholds for old field and forest recovery on more sandy soils are apparently due to higher relative rates of net soil N mineralization in more sandy soils. Calculations with the model indicate that a combination of desired future

  2. Assessing the Health Impacts of Air Pollution Regulations Using BenMAP, the Environmental Benefits Mapping and Analysis Program

    NASA Astrophysics Data System (ADS)

    Hubbell, B.; McCubbin, D.; Hallberg, A.

    2003-12-01

    The U.S. EPA Office of Air and Radiation has developed BenMAP, the environmental Benefits Mapping and Analysis Program, a new software tool for estimating the health and environmental impacts of environmental regulations. BenMAP is the US EPA's premier tool for estimating benefits associated with air pollution reduction strategies, and has recently been used in evaluating US EPA's Proposed Non-Road Diesel Vehicle Standards and the proposed Clear Skies Act legislation. BenMAP is a geographic information system (GIS) that uses modeled and monitored air quality data combined with population forecasts to develop estimates of changes in community level exposure to ambient environmental pollution (currently ambient air pollution, e.g. ozone and PM). These estimated changes in exposure to ambient pollution are used as inputs to concentration-response functions derived from the epidemiological literature, along with data on baseline incidence of health effects, i.e. county level age and cause specific mortality rates. The resulting point estimates of changes in incidence of health effects, along with their associated uncertainty distributions (currently based on reported standard errors in the literature), are then multiplied by economic unit values (represented by distributions), i.e. the cost of a hospital admission, to derive dollar estimates of health benefits. BenMAP is unique in that it uses highly detailed census and health data matched with spatially detailed environmental quality data to estimate health benefits. The program can also provide estimates of the uncertainty associated with the estimated benefits. Other features of the program include the ability to pool results from multiple studies of the same endpoint, using fixed or random effects weights, or user supplied weights. BenMAP also incorporates functions to manipulate and combine information on environmental quality from many different sources. For the current version focusing on air pollution, these

  3. A BEN-domain-containing protein associates with heterochromatin and represses transcription.

    PubMed

    Sathyan, Kizhakke M; Shen, Zhen; Tripathi, Vidisha; Prasanth, Kannanganattu V; Prasanth, Supriya G

    2011-09-15

    In eukaryotes, higher order chromatin structure governs crucial cellular processes including DNA replication, transcription and post-transcriptional gene regulation. Specific chromatin-interacting proteins play vital roles in the maintenance of chromatin structure. We have identified BEND3, a quadruple BEN domain-containing protein that is highly conserved amongst vertebrates. BEND3 colocalizes with HP1 and H3 trimethylated at K9 at heterochromatic regions in mammalian cells. Using an in vivo gene locus, we have been able to demonstrate that BEND3 associates with the locus only when it is heterochromatic and dissociates upon activation of transcription. Furthermore, tethering BEND3 inhibits transcription from the locus, indicating that BEND3 is involved in transcriptional repression through its interaction with histone deacetylases and Sall4, a transcription repressor. We further demonstrate that BEND3 is SUMOylated and that such modifications are essential for its role in transcriptional repression. Finally, overexpression of BEND3 causes premature chromatin condensation and extensive heterochromatinization, resulting in cell cycle arrest. Taken together, our data demonstrate the role of a novel heterochromatin-associated protein in transcriptional repression. PMID:21914818

  4. Student Intern Ben Freed Competes as Finalist in Intel STS Competition, Three Other Interns Named Semifinalists | Poster

    Cancer.gov

    By Ashley DeVine, Staff Writer Werner H. Kirstin (WHK) student intern Ben Freed was one of 40 finalists to compete in the Intel Science Talent Search (STS) in Washington, DC, in March. “It was seven intense days of interacting with amazing judges and incredibly smart and interesting students. We met President Obama, and then the MIT astronomy lab named minor planets after each of us,” Freed said of the competition.  

  5. Geomorphological activity during the Lateglacial in the corrie complex of Ben Hope, NW Highlands, Scotland

    NASA Astrophysics Data System (ADS)

    Mills, S. C.; Lukas, S.

    2009-04-01

    The Lateglacial Period in Europe is characterised by pronounced climatic fluctuations and encompasses the time from Devensian (Weichselian) ice sheet retreat to the beginning of the Holocene. The most notable period in terms of geomorphological activity is the Younger Dryas (12.7-11.5 ka BP), during which an ice cap centred on the main watershed covered c. 350 km2 of the NW Highlands (Lukas and Bradwell, 2009); only one individual corrie glacier existed on an isolated mountain massif (Arkle) to the north of the main watershed in this area during the Younger Dryas (Carr et al., 2009). The study site at Ben Hope, c. 10 km east of the main ice cap, is the most prominent and highest mountain in this area (927 m asl). At this site, Sissons (1977) suggested the presence of small glaciers in the three corries on the eastern side of the mountain, based on the identification of lateral moraines and a series of hummocky moraines. However, recent mapping of the field evidence by the present authors suggests that the landform assemblages in the corrie might have been misinterpreted from aerial photographs: The undulating ground at the toe of the corrie (A) resembles openwork blocks with a-axes of up to 5 m that are angular to subangular. The corrie headwall contains (B) an elongated accumulation of large blocks (a-axes up to 10 m) between 644 m and 740 m a.s.l. This feature displays a steep front (35-40°) and a central depression that is elongated downslope. Above this feature, a truncated spur displaying antiscarps can be observed (C). The centre of the corrie is occupied by a lochan and two coherent, 15 m-high, blocky ridges that are covered by up to 2 m of peat (D). The evidence is at present interpreted as (A) undulating rockfall debris, possibly on to former glacier ice which melted during retreat, due to the presence of depressions and lack of spatial order. (B) is interpreted as a tongue-shaped rock glacier, (C) as a localised rockslope failure originating from the NE

  6. Lattice Boltzmann implementation of the three-dimensional Ben-Naim potential for water-like fluids

    NASA Astrophysics Data System (ADS)

    Moradi, Nasrollah; Greiner, Andreas; Rao, Francesco; Succi, Sauro

    2013-03-01

    We develop a three-dimensional lattice Boltzmann (LB) model accounting for directional interactions between water-like molecules, based on the so-called Ben-Naim (BN) potential [A. Ben-Naim, Molecular Theory of Water and Aqueous Solutions: Part I: Understanding Water (World Scientific Publishing Company, 2010); A. Ben-Naim, "Statistical mechanics of `waterlike' particles in two dimensions. I. Physical model and application of the Percus-Yevick equation," J. Chem. Phys. 54, 3682 (1971)], 10.1063/1.1675414. The water-like molecules are represented by rigid tetrahedra, with two donors and two acceptors at the corners and interacting with neighboring tetrahedra, sitting on the nodes of a regular lattice. The tetrahedra are free to rotate about their centers under the drive of the torque arising from the interparticle potential. The orientations of the water molecules are evolved in time via an overdamped Langevin dynamics for the torque, which is solved by means of a quaternion technique. The resulting advection-diffusion-reaction equation for the quaternion components is solved by a LB method, acting as a dynamic minimizer for the global energy of the fluid. By adding thermal fluctuations to the torque equation, the model is shown to reproduce some microscopic features of real water, such as an average number of hydrogen bonds per molecules (HBs) between 3 and 4, in a qualitative agreement with microscopic water models. Albeit slower than a standard LB solver for ordinary fluids, the present scheme opens up potentially far-reaching scenarios for multiscale applications based on a coarse-grained representation of the water solvent.

  7. A study of decisive factors in cross-national acquisitions - An example of BenQ and Foxconn cooperation

    NASA Astrophysics Data System (ADS)

    Tu, Kai-Jan

    2012-09-01

    As a result of globalization, the number of multinational mergers and acquisitions across the globe has grown steadily over the years. In this article I have conducted research based on two key studies: the failure and success of two companies, BenQ and Foxconn, through the mergers and acquisitions. I gain the conclusion that effective cross-border culture communication is an absolute, decisive factor in building successful relationships among companies; enterprises must develop a "cross-border culture communication motivation function" from both the acquiring and the acquired parts of the partnership. It is only then, that enterprises can exert their market and financial synergy influence to the fullest extents.

  8. [Review on fragmentary volume of original block - printed edition of Nan jing ben yi (Gist of the Classic of Questioning)].

    PubMed

    Shi, Changyong

    2002-01-01

    Nan jing ben yi (Gist of the Classic of Questioning) was written by Hua Shou of the Yuan dynasty. The extant first volume of the original block - printed edition, revised by Lü Fu, was collected in the Library of China Academy of Military Medical Science. There is a preface written by Jie Hong, a Director Ministry of Techndogy in 1366 at the front of this volume. The red seal in the first page showed that it had been collected by Yun Xiang, Pan Zuyin et al. It is highly possible that this volume is the only existing copy. PMID:12015054

  9. Federal land management, carbon sequestration, and climate change in the Southeastern U.S.: a case study with fort benning

    USGS Publications Warehouse

    Zhao, S.; Liu, S.; Li, Z.; Sohl, T.L.

    2010-01-01

    Land use activities can have a major impact on the temporal trendsandspatialpatternsofregionalland-atmosphereexchange of carbon. Federal lands generally have substantially different land management strategies from surrounding areas, and the carbon consequences have rarely been quantified and assessed. Using the Fort Benning Installation as a case study, we used the General Ensemble biogeochemical Modeling System (GEMS) to simulate and compare ecosystem carbon sequestration between the U.S. Army's Fort Benning and surrounding areas from 1992 to 2050. Our results indicate that the military installation sequestered more carbon than surrounding areas from 1992 to 2007 (76.7 vs 18.5 g C m-2 yr-1), and is projected to continue sequestering more carbon from 2008 to 2050 (75.7 vs 25.6 g C m-2 yr-1), mostly because of the proactive management approaches adopted on military training lands. Our results suggest that federal lands might play a positive and important role in sequestering and conserving atmospheric carbon because some anthropogenic disturbances (e.g., urbanization, forest harvesting, and agriculture) can be minimized or prevented on federal lands

  10. Nucleotide sequences of the Acinetobacter calcoaceticus benABC genes for benzoate 1,2-dioxygenase reveal evolutionary relationships among multicomponent oxygenases.

    PubMed Central

    Neidle, E L; Hartnett, C; Ornston, L N; Bairoch, A; Rekik, M; Harayama, S

    1991-01-01

    The nucleotide sequences of the Acinetobacter calcoaceticus benABC genes encoding a multicomponent oxygenase for the conversion of benzoate to a nonaromatic cis-diol were determined. The enzyme, benzoate 1,2-dioxygenase, is composed of a hydroxylase component, encoded by benAB, and an electron transfer component, encoded by benC. Comparison of the deduced amino acid sequences of BenABC with related sequences, including those for the multicomponent toluate, toluene, benzene, and naphthalene 1,2-dioxygenases, indicated that the similarly sized subunits of the hydroxylase components were derived from a common ancestor. Conserved cysteine and histidine residues may bind a [2Fe-2S] Rieske-type cluster to the alpha-subunits of all the hydroxylases. Conserved histidines and tyrosines may coordinate a mononuclear Fe(II) ion. The less conserved beta-subunits of the hydroxylases may be responsible for determining substrate specificity. Each dioxygenase had either one or two electron transfer proteins. The electron transfer component of benzoate dioxygenase, encoded by benC, and the corresponding protein of the toluate 1,2-dioxygenase, encoded by xylZ, were each found to have an N-terminal region which resembled chloroplast-type ferredoxins and a C-terminal region which resembled several oxidoreductases. These BenC and XylZ proteins had regions similar to certain monooxygenase components but did not appear to be evolutionarily related to the two-protein electron transfer systems of the benzene, toluene, and naphthalene 1,2-dioxygenases. Regions of possible NAD and flavin adenine dinucleotide binding were identified. PMID:1885518

  11. WWBT? What Would Ben Think about Killer Apps, Cutting Edges, and Tipping Points in the History of Weather and Climate?

    NASA Astrophysics Data System (ADS)

    Fleming, J. R.

    2006-12-01

    This paper examines the history of weather and climate since 1706 along three intertwined analytical axes: technology (killer apps), science (cutting edges), and social issues (tipping points). For example, Franklin's best-known killer app, the lightning rod, gains added significance when seen in light of his cutting edge contributions to the science of electricity, his lifelong promotion of useful knowledge, and the societal tipping point his work triggered in our relationship to the sky. Subsequently, other major tipping points and conceptual shifts followed the introduction of telegraphy, radio, television, digital computers, and rocketry into meteorology. Following an analysis of the career and contributions of Benjamin Franklin (1706-1790), the paper examines later historical moments and watersheds, not merely in retrospect, but from the perspective of leading participants at the time. It focuses on technologies of significant promise, especially those involving electro- magnetism, up to and including the dawn of the twenty-first century, and asks playfully, "What would Ben think?"

  12. Lattice Boltzmann implementation of the three-dimensional Ben-Naim potential for water-like fluids.

    PubMed

    Moradi, Nasrollah; Greiner, Andreas; Rao, Francesco; Succi, Sauro

    2013-03-28

    We develop a three-dimensional lattice Boltzmann (LB) model accounting for directional interactions between water-like molecules, based on the so-called Ben-Naim (BN) potential [A. Ben-Naim, Molecular Theory of Water and Aqueous Solutions: Part I: Understanding Water (World Scientific Publishing Company, 2010); "Statistical mechanics of 'waterlike' particles in two dimensions. I. Physical model and application of the Percus-Yevick equation," J. Chem. Phys. 54, 3682 (1971)]. The water-like molecules are represented by rigid tetrahedra, with two donors and two acceptors at the corners and interacting with neighboring tetrahedra, sitting on the nodes of a regular lattice. The tetrahedra are free to rotate about their centers under the drive of the torque arising from the interparticle potential. The orientations of the water molecules are evolved in time via an overdamped Langevin dynamics for the torque, which is solved by means of a quaternion technique. The resulting advection-diffusion-reaction equation for the quaternion components is solved by a LB method, acting as a dynamic minimizer for the global energy of the fluid. By adding thermal fluctuations to the torque equation, the model is shown to reproduce some microscopic features of real water, such as an average number of hydrogen bonds per molecules (HBs) between 3 and 4, in a qualitative agreement with microscopic water models. Albeit slower than a standard LB solver for ordinary fluids, the present scheme opens up potentially far-reaching scenarios for multiscale applications based on a coarse-grained representation of the water solvent. PMID:23556707

  13. Module Curriculum Guide: A Study of Ourstory in Africa Pre and Post "His-story." Reference Works of Yosef Ben Jochannan.

    ERIC Educational Resources Information Center

    Alexander, E. Curtis

    The published and unpublished works of Dr. Yosef ben-Jochannan serve as the basis for this reference guide to African history and culture. The guide is intended for use by curriculum developers and high school and college level classroom teachers as they develop and implement courses on African studies and/or units to be incorporated into existing…

  14. 75 FR 38179 - Proposed Collection; Comment Request for Forms W-8BEN, W-8ECI, W-8EXP, and W-8IMY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-01

    ...- 8ECI-180,000; Form W-8EXP-240; Form W-8IMY-400. Estimated Time Per Respondent: Form W-8BEN-13 hr., 47 min.; Form W- 8ECI-10 hr., 33 min.; Form W-8EXP-18 hr., 28 min.; Form W-8IMY-16 hr., 46 min....

  15. Who Are Students of Physical Therapy? A Case Study: The Academic College of Judea and Samaria and the Ben Gurion University

    ERIC Educational Resources Information Center

    Davidovitch, Nitza; Danziger, Yosefa

    2006-01-01

    This study focuses on the attributes of students of Physical Therapy, and compares the profiles of students of Physical Therapy in two institutions of higher learning in Israel, Ben Gurion University (BGU) and the Academic College of Judea and Samaria (ACJS), Israel's largest public academic college. This study focuses on this department, where…

  16. 76 FR 60452 - In the Matter of: Bahram Maghazehe, a.k.a. Benjamin Maghazehe, a.k.a. Ben Maghazehe, 154 Sequoia...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-29

    ... most recent being that of August 12, 2011 (76 FR 50,661 (Aug. 16, 2011)), has continued the Regulations... Bureau of Industry and Security In the Matter of: Bahram Maghazehe, a.k.a. Benjamin Maghazehe, a.k.a. Ben Maghazehe, 154 Sequoia Drive, Newtown, PA 18940, Respondent; Order Relating to Bahram Maghazehe...

  17. Expression of the cell adhesion proteins BEN/SC1/DM-GRASP and TAG-1 defines early steps of axonogenesis in the human spinal cord.

    PubMed

    Karagogeos, D; Pourquié, C; Kyriakopoulou, K; Tavian, M; Stallcup, W; Péault, B; Pourquié, O

    1997-03-17

    We have studied the expression pattern of two cell adhesion proteins of the immunoglobin (Ig) superfamily, BEN/SC1/DM-GRASP (BEN) and the transient axonal glycoprotein TAG-1, during the development of the human nervous system. This study was performed by immunocytochemistry on sections of human embryos ranging from 4 to 13 weeks postconception. The overall distribution of the two proteins during development is very similar to that reported in other vertebrate species, but several important differences have been observed. Both proteins exhibit a transient expression on selected neuronal populations, which include the motor and the sensory neurons. In addition, BEN was also detected on virtually all neurons derived from the neural crest as well as in nonneuronal tissues. A major difference of expression with the chick embryo is that, in the motor neurons, BEN expression was not observed at early stages of development, thus arguing against a role of this molecule in pathfinding and fasciculation. BEN was observed to be restricted to subsets of motor neurons, such as the medial column at the upper limb level. Expression was also detected in a laterodorsal population of the ventral horn cells, which are likely to correspond to migrating preganglionic neurons that originate from the motor pool at the thoracic level. TAG-1 was found on commissural neurons and weakly on the sympathetic neurons; it was also detected on restricted nonneuronal populations. In addition, we observed TAG-1 expression in fibers that could correspond either to subsets of dorsal root ganglia (DRGs) central afferences (including the Ia fibers) or to the axons of association interneurons and in scattered motoneurons likely to correspond either to preganglionic neurons, to gamma-motoneurons, or to late-born motoneurons. Therefore, our results indicate that the molecular strategies used to establish the axonal scaffolding of the nervous system in humans are extremely conserved among the different

  18. A Honeycomb BeN2 Sheet with a Desirable Direct Band Gap and High Carrier Mobility.

    PubMed

    Zhang, Cunzhi; Sun, Qiang

    2016-07-21

    Using global particle-swarm optimization method, we report, for the first time, a BeN2 sheet (h-BeN2) with a graphene-like honeycomb lattice but displaying a direct band gap. Symmetry group analysis indicates that the dipole transition is allowed between the conduction band minimum and the valence band maximum. Although the direct band gap of 2.23 eV is close to that (2.14 eV) of MoS2 sheet, the h-BeN2 sheet has additional advantages: the direct band gap feature of the h-BeN2 sheet is quite insensitive to the layer stacking pattern and layer number, in contrast to the well-known direct-to-indirect band gap transition observed in TMDs and h-BN sheets. When rolled up, all the resulting h-BeN2 nanotubes have direct band gaps independent of chirality and diameter. Furthermore, the intrinsic acoustic-phonon-limited carrier mobility of the h-BeN2 sheet can reach ∼10(5) cm(2) V(-1) s(-1) for electron and ∼10(4) cm(2) V(-1) s(-1) for hole, which are higher than that of MoS2 and black phosphorus. PMID:27338078

  19. Projected climate and vegetation changes and potential biotic effects for Fort Benning, Georgia; Fort Hood, Texas; and Fort Irwin, California

    USGS Publications Warehouse

    Shafer, S.L.; Atkins, J.; Bancroft, B.A.; Bartlein, P.J.; Lawler, J.J.; Smith, B.; Wilsey, C.B.

    2012-01-01

    The responses of species and ecosystems to future climate changes will present challenges for conservation and natural resource managers attempting to maintain both species populations and essential habitat. This report describes projected future changes in climate and vegetation for three study areas surrounding the military installations of Fort Benning, Georgia, Fort Hood, Texas, and Fort Irwin, California. Projected climate changes are described for the time period 2070–2099 (30-year mean) as compared to 1961–1990 (30-year mean) for each study area using data simulated by the coupled atmosphere-ocean general circulation models CCSM3, CGCM3.1(T47), and UKMO-HadCM3, run under the B1, A1B, and A2 future greenhouse gas emissions scenarios. These climate data are used to simulate potential changes in important components of the vegetation for each study area using LPJ, a dynamic global vegetation model, and LPJ-GUESS, a dynamic vegetation model optimized for regional studies. The simulated vegetation results are compared with observed vegetation data for the study areas. Potential effects of the simulated future climate and vegetation changes for species and habitats of management concern are discussed in each study area, with a particular focus on federally listed threatened and endangered species.

  20. ODEs approaches in modeling fibrosis. Comment on "Towards a unified approach in the modeling of fibrosis: A review with research perspectives" by Martine Ben Amar and Carlo Bianca

    NASA Astrophysics Data System (ADS)

    Ragusa, Maria Alessandra; Russo, Giulia

    2016-07-01

    Ben Amar and Bianca valuably reviewed the state of the art of fibrosis modeling approach scenario [1]. Each paragraph identifies and examines a specific theoretical tool according to their scale level (molecular, cellular or tissue). For each of them it is shown the area of application, along with a clear description of strong and weak points. This critical analysis denotes the necessity to develop a more suitable and original multiscale approach in the future [2].

  1. Similarities between the antABC-Encoded Anthranilate Dioxygenase and the benABC-Encoded Benzoate Dioxygenase of Acinetobacter sp. Strain ADP1

    PubMed Central

    Bundy, Becky M.; Campbell, Alan L.; Neidle, Ellen L.

    1998-01-01

    Acinetobacter sp. strain ADP1 can use benzoate or anthranilate as a sole carbon source. These structurally similar compounds are independently converted to catechol, allowing further degradation to proceed via the β-ketoadipate pathway. In this study, the first step in anthranilate catabolism was characterized. A mutant unable to grow on anthranilate, ACN26, was selected. The sequence of a wild-type DNA fragment that restored growth revealed the antABC genes, encoding 54-, 19-, and 39-kDa proteins, respectively. The deduced AntABC sequences were homologous to those of class IB multicomponent aromatic ring-dihydroxylating enzymes, including the dioxygenase that initiates benzoate catabolism. Expression of antABC in Escherichia coli, a bacterium that normally does not degrade anthranilate, enabled the conversion of anthranilate to catechol. Unlike benzoate dioxygenase (BenABC), anthranilate dioxygenase (AntABC) catalyzed catechol formation without requiring a dehydrogenase. In Acinetobacter mutants, benC substituted for antC during growth on anthranilate, suggesting relatively broad substrate specificity of the BenC reductase, which transfers electrons from NADH to the terminal oxygenase. In contrast, the benAB genes did not substitute for antAB. An antA point mutation in ACN26 prevented anthranilate degradation, and this mutation was independent of a mucK mutation in the same strain that prevented exogenous muconate degradation. Anthranilate induced expression of antA, although no associated transcriptional regulators were identified. Disruption of three open reading frames in the immediate vicinity of antABC did not prevent the use of anthranilate as a sole carbon source. The antABC genes were mapped on the ADP1 chromosome and were not linked to the two known supraoperonic gene clusters involved in aromatic compound degradation. PMID:9721284

  2. Comments on "Modified wind chill temperatures determined by a whole body thermoregulation model and human-based convective coefficients" by Ben Shabat, Shitzer and Fiala (2013) and "Facial convective heat exchange coefficients in cold and windy environments estimated from human experiments" by Ben Shabat and Shitzer (2012)

    NASA Astrophysics Data System (ADS)

    Osczevski, Randall J.

    2014-08-01

    Ben Shabat et al. (Int J Biometeorol 56(4):639-51, 2013) present revised charts for wind chill equivalent temperatures (WCET) and facial skin temperatures (FST) that differ significantly from currently accepted charts. They credit these differences to their more sophisticated calculation model and to the human-based equation that it used for finding the convective heat transfer coefficient (Ben Shabat and Shitzer, Int J Biometeorol 56:639-651, 2012). Because a version of the simple model that was used to create the current charts accurately reproduces their results when it uses the human-based equation, the differences that they found must be entirely due to this equation. In deriving it, Ben Shabat and Shitzer assumed that all of the heat transfer from the surface of their cylindrical model was due to forced convection alone. Because several modes of heat transfer were occurring in the human experiments they were attempting to simulate, notably radiation, their coefficients are actually total external heat transfer coefficients, not purely convective ones, as the calculation models assume. Data from the one human experiment that used heat flux sensors supports this conclusion and exposes the hazard of using a numerical model with several adjustable parameters that cannot be measured. Because the human-based equation is faulty, the values in the proposed charts are not correct. The equation that Ben Shabat et al. (Int J Biometeorol 56(4):639-51, 2013) propose to calculate WCET should not be used.

  3. 40 CFR 721.1750 - 1H-Benzotriazole, 5-(pen-tyl-oxy)- and 1H-ben-zo-tri-a-zole, 5-(pen-tyl-oxy)-, sodium and...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 1H-ben-zo-tri-a-zole, 5-(pen-tyl-oxy)-, sodium and potassium salts. 721.1750 Section 721.1750... 1H-Benzotriazole, 5-(pen-tyl-oxy)- and 1H-ben-zo-tri-a-zole, 5-(pen-tyl-oxy)-, sodium and potassium...-tyl-oxy)-, sodium salt (PMN P-92-35), and 1H-benzotriazole, 5-(pentyloxy)- , potassium salt (PMN...

  4. 40 CFR 721.1750 - 1H-Benzotriazole, 5-(pen-tyl-oxy)- and 1H-ben-zo-tri-a-zole, 5-(pen-tyl-oxy)-, sodium and...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 1H-ben-zo-tri-a-zole, 5-(pen-tyl-oxy)-, sodium and potassium salts. 721.1750 Section 721.1750... 1H-Benzotriazole, 5-(pen-tyl-oxy)- and 1H-ben-zo-tri-a-zole, 5-(pen-tyl-oxy)-, sodium and potassium...-tyl-oxy)-, sodium salt (PMN P-92-35), and 1H-benzotriazole, 5-(pentyloxy)- , potassium salt (PMN...

  5. 40 CFR 721.1750 - 1H-Benzotriazole, 5-(pen-tyl-oxy)- and 1H-ben-zo-tri-a-zole, 5-(pen-tyl-oxy)-, sodium and...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 1H-ben-zo-tri-a-zole, 5-(pen-tyl-oxy)-, sodium and potassium salts. 721.1750 Section 721.1750... 1H-Benzotriazole, 5-(pen-tyl-oxy)- and 1H-ben-zo-tri-a-zole, 5-(pen-tyl-oxy)-, sodium and potassium...-tyl-oxy)-, sodium salt (PMN P-92-35), and 1H-benzotriazole, 5-(pentyloxy)- , potassium salt (PMN...

  6. 40 CFR 721.1750 - 1H-Benzotriazole, 5-(pen-tyl-oxy)- and 1H-ben-zo-tri-a-zole, 5-(pen-tyl-oxy)-, sodium and...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 1H-ben-zo-tri-a-zole, 5-(pen-tyl-oxy)-, sodium and potassium salts. 721.1750 Section 721.1750... 1H-Benzotriazole, 5-(pen-tyl-oxy)- and 1H-ben-zo-tri-a-zole, 5-(pen-tyl-oxy)-, sodium and potassium...-tyl-oxy)-, sodium salt (PMN P-92-35), and 1H-benzotriazole, 5-(pentyloxy)- , potassium salt (PMN...

  7. 40 CFR 721.1750 - 1H-Benzotriazole, 5-(pen-tyl-oxy)- and 1H-ben-zo-tri-a-zole, 5-(pen-tyl-oxy)-, sodium and...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 1H-ben-zo-tri-a-zole, 5-(pen-tyl-oxy)-, sodium and potassium salts. 721.1750 Section 721.1750... 1H-Benzotriazole, 5-(pen-tyl-oxy)- and 1H-ben-zo-tri-a-zole, 5-(pen-tyl-oxy)-, sodium and potassium...-tyl-oxy)-, sodium salt (PMN P-92-35), and 1H-benzotriazole, 5-(pentyloxy)- , potassium salt (PMN...

  8. Predicted Effects of Prescribed Burning and Timber Management on Forest Recovery and Sustainability at Fort Benning, Georgia

    SciTech Connect

    Garten, C.T.,JR.

    2004-04-13

    The objective of this work was to use a simple compartment model of soil carbon (C) and nitrogen (N) dynamics to predict forest recovery on degraded soils and forest sustainability, following recovery, under different regimes of prescribed fire and timber management. This report describes the model and a model-based analysis of the effect of prescribed burning and forest thinning or clearcutting on stand recovery and sustainability at Fort Benning, GA. I developed the model using Stella{reg_sign} Research Software (High Performance Systems, Inc., Hanover, NH) and parameterized the model using data from field studies at Fort Benning, literature sources, and parameter fitting. The model included (1) a tree biomass submodel that predicted aboveground and belowground tree biomass, (2) a litter production submodel that predicted the dynamics of herbaceous aboveground and belowground biomass, (3) a soil C and N submodel that predicted soil C and N stocks (to a 30 cm soil depth) and net soil N mineralization, and (4) an excess N submodel that calculated the difference between predicted plant N demands and soil N supplies. There was a modeled feedback from potential excess N (PEN) to tree growth such that forest growth was limited under conditions of N deficiency. Two experiments were performed for the model-based analysis. In the first experiment, forest recovery from barren soils was predicted for 100 years with or without prescribed burning and with or without timber management by thinning or clearcutting. In the second experiment, simulations began with 100 years of predicted forest growth in the absence of fire or harvesting, and sustainability was predicted for a further 100 years either with or without prescribed burning and with or without forest management. Four performance variables (aboveground tree biomass, soil C stocks, soil N stocks, and PEN) were used to evaluate the predicted effects of timber harvesting and prescribed burning on forest recovery and

  9. Ben Franklin's Scientific Amusements

    NASA Astrophysics Data System (ADS)

    Herschbach, Dudley

    2003-04-01

    As an American icon, Benjamin Franklin is often portrayed as wise and canny in business and politics, earnestly pursuing and extolling diligence, sensible conduct, pragmatism, and good works. Also legendary are some of his inventions, particularly the lightning rod, bifocals, and an efficient wood-burning stove. The iconic image is misleading in major respects. Today, surprisingly few people appreciate that, in the 18th century, Franklin was greatly esteemed throughout Europe as a scientist (termed then a "natural philosopher.") He was hailed as the "Newton of Electricity." Indeed, until Franklin, electricity seemed more mysterious than had gravity in Newton's time, and lightning was considered the wrath of God. By his own account, Franklin's studies of electricity and many other phenomena were prompted not by practical aims, but by his playful curiosity--which often became obsessive. Also not generally appreciated is the importance of Franklin's scientific reputation in enhancing his efforts to obtain French support for the American Revolution.

  10. Ben Franklin's Junto Revisited.

    ERIC Educational Resources Information Center

    Merriam, Sharan

    1979-01-01

    Describes the Colonial Junto organized by Benjamin Franklin in 1727 as a discussion club to debate politics, morals, and natural philosophy, and the later American Philosophical Society which extended (and continues) the subject knowledge. The present-day Junto Center for Continuing Education in Philadelphia is an adult education information…

  11. Turning Around Ben Franklin

    ERIC Educational Resources Information Center

    Lozen, Stephen

    2010-01-01

    One would think that being the nation's only private, urban, two-year technical college might be a source of some notoriety, especially if that institution also traces its history back to a bequest in Benjamin Franklin's will. But even among New England's higher education community, Boston's Benjamin Franklin Institute of Technology (BFIT) is a…

  12. [Increase of entomological indices during the pre-epidemic period of dengue in Ben Tre, South Vietnam].

    PubMed

    Nguyen, T P Q; Luu, L L; Vu, T Q H; Buisson, Y

    2011-10-01

    Dengue has emerged in Vietnam 50 years ago and since has become endemo-epidemic throughout the whole country. Each year, major epidemics of dengue fever (DF) and dengue hemorrhagic fever (DHF) hit South Vietnam during the rainy season, causing significant morbidity and mortality, especially among young children. The only preventive measure is vector control, but it is often implemented too late or indiscriminately. The aim of this study was to investigate, in the pre-epidemic stage, the existence of significant changes in vector indices, which will predict DF/DHF outbreaks. We conducted a descriptive transversal study, repeated once a month for four months (March to June) in the village of Locthuan (province Ben Tre) in the Mekong's delta. Adult mosquitoes were caught in 30 houses, and larvae were collected in water holding containers of 50 houses. The houses were randomly selected. Vector densities were calculated according to the indices recommended by WHO. Virological analysis was carried out on lots of female Aedes and larvae in order to determine viral infection rates. Catches of adult mosquitoes collected 496 specimens including 329 Aedes, 139 Culex and 28 Anopheles. Aedes aegypti was present in 63% of visited homes that is an average density of 1.8 mosquitoes per house. The increase in imaginal indices during the 4 months was not significant. The survey of breeding sites of Ae. aegypti identified 1292 water containers in which 71,569 larval specimens were collected. The values of house index, container index [CI] and Breteau index [BI] increased each month, the latter from 166 to 442. This increase was significant for CI and BI. Breeding sites were mostly intra-home, mainly consisting of large and small ceramic jars. Larval density of Ae. aegypti in the containers also increased significantly over the 4 months. It was correlated with the lack of cover and predators such as Mesocyclops spp., Micronecta spp. and larvivorous fishes. Cultivation of 15 pools of

  13. [Classes of crude drugs and its distribution of producing area in the attached illustrations in Ben cao tu jing (Illustrated Classic of Materia Medica)].

    PubMed

    Xu, T; Peng, H S

    2016-03-01

    Ben cao tu jing (Illustrated Classic of Materia Medica) is the earliest extant atlas book of materia medica in China, with 933 attached drawings. Among them, the largest portion, amounting to 670, are herbaceous plants, mostly commonly used, with definite marks of the origin producing areas, distributed across 149 administrative divisions(prefectures and counties) of the Song Dynasty, most of them in Northern area which were distributed denser than those in Southern area. The densest ones were located in Southern Shanxi, Eastern Sichuan and Eastern Anhui. In the attached drawings, the frequency of highest occurrence appeared in this Classic are three prefectures, Chuzhou, Shizhou and Guangzhou. PMID:27255195

  14. Potential DNA slippage structures acquired during evolutionary divergence of Acinetobacter calcoaceticus chromosomal benABC and Pseudomonas putida TOL pWW0 plasmid xylXYZ, genes encoding benzoate dioxygenases.

    PubMed Central

    Harayama, S; Rekik, M; Bairoch, A; Neidle, E L; Ornston, L N

    1991-01-01

    The xylXYZ DNA region is carried on the TOL pWW0 plasmid in Pseudomonas putida and encodes a benzoate dioxygenase with broad substrate specificity. The DNA sequence of the region is presented and compared with benABC, the chromosomal region encoding the benzoate dioxygenase of Acinetobacter calcoaceticus. Corresponding genes from the two biological sources share common ancestry: comparison of aligned XylX-BenA, XylY-BenB, and XylZ-BenC amino acid sequences revealed respective identities of 58.3, 61.3, and 53%. The aligned genes have diverged to assume G+C contents that differ by 14.0 to 14.9%. Usage of the unusual arginine codons AGA and AGG appears to have been selected in the P. putida xylX gene as it diverged from the ancestor it shared with A. calcoaceticus benA. Homologous A. calcoaceticus and P. putida genes exhibit different patterns of DNA sequence repetition, and analysis of one such pattern suggests that mutations creating different DNA slippage structures made a significant contribution to the evolutionary divergence of xylX. PMID:1938949

  15. [Study on carving workers of Chong xiu zheng he jing shi zheng lei bei yong ben cao (Revised Prepared Materia Medica Classified under Syndromes in Zhenghe Period) published by Huiming Xuan (Huiming Sanctum)].

    PubMed

    Liang, Fei; Li, Jian; Zhang, Wei; Zhang, Rui-Xian

    2012-11-01

    The ancient carving workers have made a great contribution to the xylographic printing art in ancient China, so the studies on them are significant for a survey of ancient Chinese printing history, and for the identification of ancient Chinese books edition. Zheng lei ben cao published by Huiming Xuan (Huiming Sanctum) in the Jin and Yuan dynasties, which is the earliest extant edition of Zhenghe version system of Zheng lei ben cao and has important literature value. Thirty carving workers were involved in its printing process. On the whole, these workers had a relatively high technique and completed a remarkably fine work. In addition to lettering, 28 persons of them also made a total of 536 pages with 900 exquisite engraving illustrations on Chinese materia medica included in this book. Because of the high levels on carving, this precious book has been the representative of Pingshui edition, which has a great reputation but has very few works now. PMID:23363847

  16. Chinese herbal medicine formula Gu-Ben-Fang-Xiao-Tang attenuates airway inflammation by modulating Th17/Treg balance in an ovalbumin-induced murine asthma model

    PubMed Central

    Ruan, Guiying; Tao, Baohong; Wang, Dongguo; Li, Yong; Wu, Jingyi; Yin, Genquan

    2016-01-01

    Gu-Ben-Fang-Xiao-Tang (GBFXT) is a traditional Chinese medicine formula consisting of 11 medicinal plants, which has been used in the treatment of asthma. The present study aimed to determine the protective effects and the underlying mechanisms of GBFXT on ovalbumin (OVA)-induced allergic inflammation in a mouse model of allergic asthma. A total of 50 mice were randomly assigned to the following five experimental groups: Normal, model, montelukast (2.6 mg/kg), 12 g/kg GBFXT and 36 g/kg GBFXT groups. Airway responsiveness was measured using the forced oscillation technique, while differential cell count in the bronchoalveolar lavage fluid (BALF) was measured by Wright-Giemsa staining. Histological assessment was performed by hematoxylin and eosin staining, while BALF levels of Th17/Treg cytokines were measured by enzyme-linked immunosorbent assay, and the proportions of Th17 and Treg cells were evaluated by flow cytometry. The results showed that GBFXT suppressed airway hyperresponsiveness during methacholine-induced constriction, reduced the percentage of leukocytes and eosinophils, and resulted in decreased absolute neutrophil infiltration in lung tissue. In addition, GBFXT treatment significantly decreased the IL-17A cytokine level and increased the IL-10 cytokine level in the BALF. Furthermore, GBFXT significantly suppressed Th17 cells and increased Treg cells in asthmatic mice. In conclusion, the current results demonstrated that GBFXT may effectively inhibit the progression of airway inflammation in allergic asthma, partially by modulating the Th17/Treg cell balance.

  17. [Textual research on Guang dong xin yu (New Sayings of Guangdong) quoted in Ben cao gang mu shi yi (Supplements to Compendium of Materia Medica].

    PubMed

    Zhang, Ruixian; Zhang, Wei; Li, Jian; Liang, Fei

    2014-05-01

    Altogether 15 terms for Guang dong xin yu (New Sayings of Guangdong) were used in Ben cao gang mu shi yi (Supplements to Compendium of Materia Medica), including Yue yu (Cantonese sayings), Chong yu (Sayings from Insect Drug), Jie yu (Sayings from Crustacean Drug), Xin yu (New Sayings), Yue hai xiang yu (Fragrant Sayings from Cantonese Region), Yue zhi mu yu (Sayings from Plants in Cantonese Annals), Guang dong suo yu (Trivial Sayings from Guangdong), Yue shan lu (Records of Cantonese Mountains), Yue lu (Cantonese Records), Jiao guang lu (Joint Guangdong Records), Yue cao zhi (Records of Cantonese Grasses), Guang guo lu (Records of Guangdong Fruits), Nan yue suo ji (Trivial Records of Southern Canton), Guang zhi (Guangdong Records), Yue zhi (Cantonese Records) etc. dealing with 57 sorts of drugs (with individual overlapping ones), the author of Xin yu was Qu Dajun, a surviving fogy of the Ming Dynasty actively involved in the activities to restore the old dynasty and resist the Qing Dynasty, and was persecuted in the literary inquisition in which his works were burnt so that Zhao Xuemin, when quoting his texts, had to go in a roundabout way. PMID:25208840

  18. Evaluation of health benefit using BenMAP-CE with an integrated scheme of model and monitor data during Guangzhou Asian Games.

    PubMed

    Ding, Dian; Zhu, Yun; Jang, Carey; Lin, Che-Jen; Wang, Shuxiao; Fu, Joshua; Gao, Jian; Deng, Shuang; Xie, Junping; Qiu, Xuezhen

    2016-04-01

    Guangzhou is the capital and largest city (land area: 7287 km(2)) of Guangdong province in South China. The air quality in Guangzhou typically worsens in November due to unfavorable meteorological conditions for pollutant dispersion. During the Guangzhou Asian Games in November 2010, the Guangzhou government carried out a number of emission control measures that significantly improved the air quality. In this paper, we estimated the acute health outcome changes related to the air quality improvement during the 2010 Guangzhou Asian Games using a next-generation, fully-integrated assessment system for air quality and health benefits. This advanced system generates air quality data by fusing model and monitoring data instead of using monitoring data alone, which provides more reliable results. The air quality estimates retain the spatial distribution of model results while calibrating the value with observations. The results show that the mean PM2.5 concentration in November 2010 decreased by 3.5 μg/m(3) compared to that in 2009 due to the emission control measures. From the analysis, we estimate that the air quality improvement avoided 106 premature deaths, 1869 cases of hospital admission, and 20,026 cases of outpatient visits. The overall cost benefit of the improved air quality is estimated to be 165 million CNY, with the avoided premature death contributing 90% of this figure. The research demonstrates that BenMAP-CE is capable of assessing the health and cost benefits of air pollution control for sound policy making. PMID:27090690

  19. Reviews Book: Big Ben Book: Mini Weapons of Mass Destruction Equipment: Waves and Radiation Sample Pack Book: The Exploratorium Science Snackbook Book: Super Structures Book: The Universe and the Atom

    NASA Astrophysics Data System (ADS)

    2010-11-01

    WE RECOMMEND Mini Weapons of Mass Destruction A pictorial guide to making safe mini weapons Waves and Radiation Sample Pack Pack shines light on the electromagnetic spectrum The Exploratorium Science Snackbook Book is full of ideas for fascinating physics demonstrations Super Structures The science of bridges, buildings, dams and engineering WORTH A LOOK Big Ben The physics of the world-famous clock The Universe and the Atom A comprehensive guide to physics

  20. The remodeling of the fibers texture Comment on "Towards a unified approach in the modeling of fibrosis: A review with research perspectives" by Martine Ben Amar and Carlo Bianca

    NASA Astrophysics Data System (ADS)

    Napoli, Gaetano

    2016-07-01

    The term fibrosis refers to the development of fibrous connective tissue, in an organ or in a tissue, as a reparative response to injury or damage. The review article by Ben Amar and Bianca [1] proposes a unified multiscale approach for the modeling of fibrosis, accounting for phenomena occurring at different spatial scales (molecular, cellular and macroscopic). The main aim is to define a general unified framework able to describe the mechanisms, not yet completely understood, that trigger physiological and pathological fibrosis.

  1. Public health benefits of reducing air pollution in Shanghai: a proof-of-concept methodology with application to BenMAP.

    PubMed

    Voorhees, A Scott; Wang, Jiandong; Wang, Cuicui; Zhao, Bin; Wang, Shuxiao; Kan, Haidong

    2014-07-01

    In recent years, levels of particulate matter (PM) air pollution in China have been relatively high, exceeding China's Class II standards in many cities and impacting public health. This analysis takes Chinese health impact functions and underlying health incidence, applies 2010-2012 modeled and monitored PM air quality data, and estimates avoided cases of mortality and morbidity in Shanghai, assuming achievement of China's Class II air quality standards. In Shanghai, the estimated avoided all cause mortality due to PM10 ranged from 13 to 55 cases per day and from 300 to 800 cases per year. The estimated avoided impact on hospital admissions due to PM10 ranged from 230 cases to 580 cases per day and from 5400 to 7900 per year. The estimated avoided impact on all cause mortality due to PM2.5 ranged from 6 to 26 cases per day and from 39 to 1400 per year. The estimated impact on all cause mortality of a year exposure to an annual or monthly mean PM2.5 concentration ranged from 180 to 3500 per year. In Shanghai, the avoided cases of all cause mortality had an estimated monetary value ranging from 170 million yuan (1 US dollar=4.2 yuan Purchasing Power Parity) to 1200 million yuan. Avoided hospital admissions had an estimated value from 20 to 43 million yuan. Avoided emergency department visits had an estimated value from 5.6 million to 15 million yuan. Avoided outpatient visits had an estimated value from 21 million to 31 million yuan. In this analysis, available data were adequate to estimate avoided health impacts and assign monetary value. Sufficient supporting documentation was available to construct and format data sets for use in the United States Environmental Protection Agency's health and environmental assessment model, known as the Environmental Benefits Mapping and Analysis Program - Community Edition ("BenMAP-CE"). PMID:24742548

  2. Fort Benning Indianhead Townhome Renovations

    SciTech Connect

    Stephenson, R.; Roberts, S.; Butler, T.; Kim, E.

    2012-12-01

    The NAHB Research Center partnered with production builder Winchester/Camberley Homes to build a DOE Building America New Construction Test House (NCTH). This single family, detached house, located in the mixed-humid climate zone of Silver Spring, MD, was completed in June 2011. The primary goal for this house was to improve energy efficiency by 30% over the Building America B10 benchmark by developing and implementing an optimized energy solutions package design that could be cost effectively and reliably constructed on a production basis using quality management practices. The intent of this report is to outline the features of this house, discuss the implementation of the energy efficient design, and report on short-term testing results. During the interactive design process of this project, numerous iterations of the framing, air sealing, insulation, and space conditioning systems were evaluated for energy performance, cost, and practical implementation. The final design featured numerous advanced framing techniques, high levels of insulation, and the HVAC system entirely within conditioned space. Short-term testing confirmed a very tight thermal envelope and efficient and effective heating and cooling. In addition, relevant heating, cooling, humidity, energy, and wall cavity moisture data will be collected and presented in a future long-term report.

  3. Ben-Hur Staircase Climbs

    ERIC Educational Resources Information Center

    Dodge, John; Simoson, Andrew

    2012-01-01

    How many ways may one climb an even number of stairs so that left and right legs are exercised equally, that is, both legs take the same number of strides, take the same number of total stairs, and take strides of either 1 or 2 stairs at a time? We characterize the solution with a difference equation and find its generating function.

  4. XMM-Newton observation of the persistent Be/NS X-ray binary pulsar RX J0440.9+4431

    NASA Astrophysics Data System (ADS)

    La Palombara, N.; Sidoli, L.; Esposito, P.; Tiengo, A.; Mereghetti, S.

    2012-03-01

    Many X-ray accreting pulsars have a soft excess below 10 keV. This feature was also detected in faint sources and at low luminosity levels, suggesting that it is an ubiquitous phenomenon. For the high luminosity pulsars (LX > 1036 erg s-1), the fit to this component with thermal emission models usually provides low temperatures (kT < 0.5 keV) and large emission regions (R ≥ a few hundred km), hence it is referred to as a "soft" excess. Nevertheless, we previously found that in persistent, low-luminosity (LX ~ 1034 erg s-1) and long-period (P > 100 s) Be accreting pulsars the observed excess can be modeled with a rather hot (kTBB > 1 keV) black-body component of small area (RBB < 0.5 km), which can be interpreted as emission from the NS polar caps. In this paper, we present an analysis of an XMM-Newton observation of the Galactic Be pulsar RX J0440.9+4431, which is a poorly studied member of this class of sources. We find a best-fit period of P = 204.96 ± 0.02 s, which implies an average pulsar spin-down over the past 13 years of Ṗ ≃ 6 × 10-9 s s-1. The estimated source luminosity is LX ~ 8 × 1034 erg s-1, which is higher by a factor of less than ten compared to those obtained in the first source observations, but almost two orders of magnitude lower than those measured during the few outbursts that have been detected most recently. The source spectrum can be described with a power-law and black-body model, with kTBB = 1.34 ± 0.04 keV and RBB = 273 ± 16 m, suggesting a polar-cap origin of this component. Our results support the classification of RX J0440.9+4431 as a persistent Be/NS pulsar, and confirm that the hot black-body spectral component is a common property of this class of sources.

  5. Water volume and sediment volume and density in Lake Linganore between Boyers Mill Road Bridge and Bens Branch, Frederick County, Maryland, 2012

    USGS Publications Warehouse

    Sekellick, Andrew J.; Banks, William S.L.; Myers, Michael K.

    2013-01-01

    To assist in understanding sediment loadings and the management of water resources, a bathymetric survey was conducted in the part of Lake Linganore between Boyers Mill Road Bridge and Bens Branch in Frederick County, Maryland. The bathymetric survey was performed in January 2012 by the U.S. Geological Survey, in cooperation with the City of Frederick and Frederick County. A separate, but related, field effort to collect 18 sediment cores was conducted in March and April 2012. Depth and location data from the bathymetric survey and location data for the sediment cores were compiled and edited by using geographic information system (GIS) software. A three-dimensional triangulated irregular network (TIN) model of the lake bottom was created to calculate the volume of stored water in the reservoir. Large-scale topographic maps of the valley prior to inundation in 1972 were provided by the Frederick County Division of Utilities and Solid Waste Management and digitized for comparison with current (2012) conditions in order to calculate sediment volume. Cartographic representations of both water depth and sediment accumulation were produced, along with an accuracy assessment for the resulting bathymetric model. Vertical accuracies at the 95-percent confidence level for the collected data, the bathymetric surface model, and the bathymetric contour map were calculated to be 0.64 feet (ft), 1.77 ft, and 2.30 ft, respectively. A dry bulk sediment density was calculated for each of the 18 sediment cores collected during March and April 2012, and used to determine accumulated sediment mass. Water-storage capacity in the study area is 110 acre-feet (acre-ft) at a full-pool elevation 308 ft above the National Geodetic Vertical Datum of 1929, whereas total sediment volume in the study area is 202 acre-ft. These totals indicate a loss of about 65 percent of the original water-storage capacity in the 40 years since dam construction. This corresponds to an average rate of sediment

  6. Biological systems modeling in the context of fibrosis. Comment on "Towards a unified approach in the modeling of fibrosis: A review with research perspectives" by Martine Ben Amar and Carlo Bianca

    NASA Astrophysics Data System (ADS)

    Kolev, Mikhail K.

    2016-07-01

    Over the last decades the collaboration between scientists from biology, medicine and pharmacology on one side and scholars from mathematics, physics, mechanics and computer science on the other has led to better understanding of the properties of living systems, the mechanisms of their functioning and interactions with the environment and to the development of new therapies for various disorders and diseases. The target paper [1] by Ben Amar and Bianca presents a detailed description of the research methods and techniques used by biomathematicians, bioinformaticians, biomechanicians and biophysicists for studying biological systems, and in particular in the context of pathological fibrosis.

  7. L'affleurement triasique du Debadib Ben Gasseur (Nord-Ouest de la Tunisie) : diapir enraciné à épanchements latéraux dans la mer Albienne, replissé au cours des phases de compression tertiairesThe Triassic rocks of the Debadib Ben Gasseur area (northwestern Tunisia): diapir with overhangs spreading downslope in the Albian Sea and deformed during the Tertiary compressional deformations

    NASA Astrophysics Data System (ADS)

    Chikhaoui, Mongi; Jallouli, Chokri; Turki, Mohamed Moncef; Soussi, Mohamed; Braham, Ahmed; Zaghbib-Turki, Dalia

    2002-12-01

    The Triassic outcrops of the Debadib-Ben Gasseur area, located in the Kef area (northwestern Tunisia) have recently been interpreted as submarine 'salt glaciers' interbedded within the Albian deposits (J.-M. Vila et al., C. R. Acad. Sci. Paris, Ser. II 318 (1994) 1661-1667). New cartographic, drills and gravimetric data recognised evidence for an Albian diapiric stage for the Triassic rocks. The Triassic rocks as pulling out of the sedimentary cover could spread laterally as small size 'salt glaciers' before they have been deformed during the Tertiary compressional deformations. To cite this article: M. Chikhaoui et al., C. R. Geoscience 334 (2002) 1129-1133.

  8. A time for multi-scale modeling of anti-fibrotic therapies. Comment on "Towards a unified approach in the modeling of fibrosis: A review with research perspectives" by Martine Ben Amar and Carlo Bianca

    NASA Astrophysics Data System (ADS)

    Wu, Min

    2016-07-01

    The development of anti-fibrotic therapies in diversities of diseases becomes more and more urgent recently, such as in pulmonary, renal and liver fibrosis [1,2], as well as in malignant tumor growths [3]. As reviewed by Ben Amar and Bianca [4], various theoretical, experimental and in-silico models have been developed to understand the fibrosis process, where the implication on therapeutic strategies has also been frequently demonstrated (e.g., [5-7]). In [4], these models are analyzed and sorted according to their approaches, and in the end of [4], a unified multi-scale approach was proposed to understand fibrosis. While one of the major purposes of extensive modeling of fibrosis is to shed light on therapeutic strategies, the theoretical, experimental and in-silico studies of anti-fibrosis therapies should be conducted more intensively.

  9. Comparison of mathematical models of fibrosis. Comment on "Towards a unified approach in the modeling of fibrosis: A review with research perspectives" by M. Ben Amar and C. Bianca

    NASA Astrophysics Data System (ADS)

    Kachapova, Farida

    2016-07-01

    Mathematical and computational models in biology and medicine help to improve diagnostics and medical treatments. Modeling of pathological fibrosis is reviewed by M. Ben Amar and C. Bianca in [4]. Pathological fibrosis is the process when excessive fibrous tissue is deposited on an organ or tissue during a wound healing and can obliterate their normal function. In [4] the phenomena of fibrosis are briefly explained including the causes, mechanism and management; research models of pathological fibrosis are described, compared and critically analyzed. Different models are suitable at different levels: molecular, cellular and tissue. The main goal of mathematical modeling of fibrosis is to predict long term behavior of the system depending on bifurcation parameters; there are two main trends: inhibition of fibrosis due to an active immune system and swelling of fibrosis because of a weak immune system.

  10. The role of time delay in the modeling of fibrosis. Comment on "Towards a unified approach in the modeling of fibrosis: A review with research perspectives" by Martine Ben Amar and Carlo Bianca

    NASA Astrophysics Data System (ADS)

    Guerrini, Luca

    2016-07-01

    Martine Ben Amar and Carlo Bianca have written a valuable paper [1], which is a timely review of the different theoretical tools for the modeling of physiological and pathological fibrosis existing in the literature. The review [1] is written with clarity and in a simple way, which makes it understandable to a wide audience. The author presents an exhaustive exposition of the interplay between the different scholars which works in the modeling of fibrosis diseases and a survey of the main theoretical approaches, among others, ODE-based models, PDE-based models, models with internal structure, mechanics of continuum approach, agent-based models. A critical analysis discusses their applicability, including advantages and disadvantages.

  11. Agent based simulations in disease modeling Comment on "Towards a unified approach in the modeling of fibrosis: A review with research perspectives" by Martine Ben Amar and Carlo Bianca

    NASA Astrophysics Data System (ADS)

    Pappalardo, Francesco; Pennisi, Marzio

    2016-07-01

    Fibrosis represents a process where an excessive tissue formation in an organ follows the failure of a physiological reparative or reactive process. Mathematical and computational techniques may be used to improve the understanding of the mechanisms that lead to the disease and to test potential new treatments that may directly or indirectly have positive effects against fibrosis [1]. In this scenario, Ben Amar and Bianca [2] give us a broad picture of the existing mathematical and computational tools that have been used to model fibrotic processes at the molecular, cellular, and tissue levels. Among such techniques, agent based models (ABM) can give a valuable contribution in the understanding and better management of fibrotic diseases.

  12. Levi ben Gerson (1288-1344)

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    Philosopher, therologian and astronomer, born in Bagnols, Gard, France. Invented Jacob's staff, an instrument to measure the angles between stars. It is a staff with square cross-section, about 1 m long, with perforated cross-pieces which slide along the staff. The end of the staff is held at the eye and the cross-piece slid along until the two ends fit within the two stars being measured. The st...

  13. And Now, a Message for Today's Students from Ben Franklin.

    ERIC Educational Resources Information Center

    Levy, Tedd

    1991-01-01

    Suggests that Benjamin Franklin's autobiography contains many useful messages for today's students. Discusses Franklin's list of virtues that he followed in an attempt at attaining moral perfection. Includes temperance, industry, justice, tranquillity, and humility. Describes the message of Franklin's lesson as one of achieving through effort…

  14. Revisiting the Personal Essay with Ben Hamper's "Rivethead"

    ERIC Educational Resources Information Center

    Kramer, Jacob

    2011-01-01

    The personal essay--a paper in which a student brings in his or her own experience or concerns--is probably familiar to most historians. Teaching at the City University of New York, the author has found grading personal essays somewhat perplexing. They are sometimes written in response to an assignment that does not call for personal reflection.…

  15. Reply to comment by Ben-Zvi, A., D. Rosenfeld and A. Givati on the paper: Levin, Z., N. Halfon and P. Alpert, “Reassessment of rain experiments and operations in Israel including synoptic considerations,” Atmos. Res. 97, 513-525. DOI: 10.1016/j.atmosres.2010.06.011

    NASA Astrophysics Data System (ADS)

    Levin, Zev; Halfon, Noam; Alpert, Pinhas

    2011-03-01

    Levin et al. (2010; hereafter LHA) (Levin, Z., Halfon, N., Alpert, P., 2010. Reassessment of rain experiments and operations in Israel including synoptic considerations. Atmos. Res. 97, 513-525. DOI:10.1016/j.atmosres.2010.06.011.), reanalyzed the results of the operational seeding in northern Israel between 1975 and 2007 and the preceding Israel 2 cloud seeding experiment (1969-1975) and concluded that there is no net increase in precipitation over the target areas. Our analysis revealed that a synoptic bias during Israel 2 is one of the reasons for the apparent positive effect of seeding in the northern target area and the negative effect in the southern area both of which disappeared in the following experiment in the south (Israel 3; 1975-1995) and the operational seeding in the north. Ben-Zvi et al. (2010;hereafter BRG) criticized our paper primarily on the ground that we did not consider the positive results of Israel 1 experiment (1960-1967). It should be noted that in Israel 1 different seeding lines were used from those in both Israel 2 and the operational period. In addition, its raw data is not accessible anymore for reanalysis. Furthermore, Israel 2 had been designed as a confirmatory cross-over experiment to Israel 1 and failed to reproduce its promising results with double ratio (DR) of ~ 1.00, namely, zero rainfall enhancements. The same DR values were also found in Israel 3 and in the operational seeding. Therefore, because of the differences in the two experiments, the lack of access to the raw data and the disappointing results of the confirmatory experiment, we decided to concentrate our analysis on the more recent seeding activities. The attempt by BRG to explain the reduction of the DR to ~ 1.00 in the operational seeding period by the suppression due to pollution have been disproved by Alpert et al. (2008, 2009) and also fail to explain the sharp decline of the target/control ratio right at the beginning of the operational seeding period when

  16. 40 CFR 721.1150 - Substituted polyglycidyl ben-zena-mine.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... found to cause cancer, reproductive effects, kidney and liver effects in laboratory animals, and.... —Similar chemicals cause cancer, reproductive effects, and kidney and liver changes in laboratory animals. They have also caused allergic reactions in humans. —Prevent all contact with skin, eyes, and...

  17. 40 CFR 721.1150 - Substituted polyglycidyl ben-zena-mine.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... found to cause cancer, reproductive effects, kidney and liver effects in laboratory animals, and.... —Similar chemicals cause cancer, reproductive effects, and kidney and liver changes in laboratory animals. They have also caused allergic reactions in humans. —Prevent all contact with skin, eyes, and...

  18. 40 CFR 721.1150 - Substituted polyglycidyl ben-zena-mine.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... found to cause cancer, reproductive effects, kidney and liver effects in laboratory animals, and.... —Similar chemicals cause cancer, reproductive effects, and kidney and liver changes in laboratory animals. They have also caused allergic reactions in humans. —Prevent all contact with skin, eyes, and...

  19. 40 CFR 721.1150 - Substituted polyglycidyl ben-zena-mine.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... found to cause cancer, reproductive effects, kidney and liver effects in laboratory animals, and.... —Similar chemicals cause cancer, reproductive effects, and kidney and liver changes in laboratory animals. They have also caused allergic reactions in humans. —Prevent all contact with skin, eyes, and...

  20. "It's All About Ben10[TM]": Children's Play, Health and Sustainability Decisions in the Early Years

    ERIC Educational Resources Information Center

    Edwards, S.; Skouteris, H.; Rutherford, L.; Cutter-Mackenzie, A.

    2013-01-01

    In today's fast food, fast-paced consumer society, too few questions are asked about the influence of digital media on young children's health and sustainability choices, and indeed how such choices are expressed in children's play (and early childhood classrooms). By interviewing children and parents, and using such data to prompt teacher…

  1. Observing ben wyckoff: from basic research to programmed instruction and social issues.

    PubMed

    Escobar, Rogelio; Lattal, Kennon A

    2011-01-01

    L. Benjamin Wyckoff's seminal contributions to both psychological theory and application are the subject of this review. Wyckoff started his academic career as a graduate student at Indiana University, where he developed the observing-response procedure under the guidance of B. F. Skinner and C. J. Burke. At the University of Wisconsin-Madison, Wyckoff refined his mathematical theory of secondary reinforcement. This theory was the impetus for his creation of an electronic simulation of a rat running a T maze, one of the first "computer models" of learning. Wyckoff next went to Emory University, leaving there to help create two of the most successful companies dedicated to the advancement of programmed instruction and teaching machines: Teaching Machines, Inc. and the Human Development Institute. Wyckoff's involvement in these companies epitomizes the application of basic behavior-analytic principles in the development of technology to improve education and human relationships. The emergent picture of Wyckoff is that of a man who, through his research, professional work in educational applications of behavioral principles, and active involvement in the civil rights movement of the 1960s, was strongly committed to applying behavioral science to positively influence human behavior change. PMID:22532737

  2. Some Observations of Ben Franklin Related to the Stilling of Waves by Oil

    ERIC Educational Resources Information Center

    Gugliotti, Marcos

    2007-01-01

    Benjamin Franklin's famous published work "Of the Stilling of Waves by Means of Oil" is an extract from letters between Franklin, Brownrigg, and Farsih which presents the observations on chemical study.

  3. Pulling the Parent Trigger--Forum. "Education Next" Talks with Ben Austin and Michael J. Petrilli

    ERIC Educational Resources Information Center

    Austin, Ben; Petrilli, Michael J.

    2013-01-01

    Championed by California-based Parent Revolution, and adopted first by California in early 2010, more than a half-dozen states now have parent trigger laws. The parent trigger, which allows a majority of parents at a low-performing school to vote to seize control from the local district, has been wielded at four California schools. Is the parent…

  4. Effects of Ben 10 on Kids in the Age-Group 5 to 8 Years

    ERIC Educational Resources Information Center

    Sandhu, Devendar

    2014-01-01

    "The problem with our society is that our values aren't in the right place. There's an awful lot of bleeding and naked bodies on prime-time networks, but not nearly enough cable television on public programming." --Bauvard, Evergreens Are Prudish Technology has expanded the availability of information through various routes,…

  5. The Ben Franklin Book of Easy and Incredible Experiments, Activities, Projects, and Science Fun.

    ERIC Educational Resources Information Center

    Rudy, Lisa Jo, Ed.

    Benjamin Franklin was the first great American scientist. This book contains activities which are organized into six subjects that Benjamin Franklin investigated: observation and experimentation, meteorology, electricity, sound and music, paper and printing, and lenses and vision. At the end of each chapter is a list of resources and ideas. The…

  6. Ben Franklin: A Curiosity-Driven Scientist, a Service-Driven Citizen

    NASA Astrophysics Data System (ADS)

    Herschbach, Dudley

    2003-04-01

    At the age of 42, Franklin retired from his prosperous printing business, ``to have leisure to read, study, and make experiments." The scope of his scientific work was remarkable. Beyond his key contributions to understanding electrcity, Franklin wrote major papers on population growth, on meterology, on heat conduction and evaporation, charted the Gulf Stream, studied bioluminescence and the stilling of water waves by a surface layer of oil. He also advanced arguments in favor of conservation of mass and the wave theory of light. Although always alert for practical applications, his style was that of an explorer, eager for adventure and insight. However, Franklin did not consider science as important as public service. He promoted many civic projects in Philadelphia, including a circulating library, fire department, paving of streets, hospital, and was the prime mover in founding the American Philosophical Society and an academy that evolved into the University of Pennsylvania. As well as publishing the most widely read newspaper in the colonies and his bestselling almanac, he became public printer for several of the colonies and postmaster. He lived in England 14 years as a trade representative, largely struggling in vain. At the age of 70, he undertook a decade of service as minister to France, achieving against great odds crucial diplomatic triumphs.

  7. Ben Jonson: A Collection of Critical Essays. Twentieth Century Views Series.

    ERIC Educational Resources Information Center

    Barish, Jonas A., Ed.

    One of a series of works aimed at presenting contemporary critical opinion on major authors, this collection includes essays by Jonas A. Barish, T. S. Eliot, L. C. Knights, Harry Levin, Edmund Wilson, Arthur Sale, C. H. Herford, Paul Goodman, Edward B. Partridge, Ray L. Heffner, Jr., Joseph Allen Bryant, Jr., and Dolora Cunningham--all dealing…

  8. Some Observations of Ben Franklin Related to the Stilling of Waves by Oil

    NASA Astrophysics Data System (ADS)

    Gugliotti, Marcos

    2007-06-01

    While studying the calming effect of oil on water, Benjamin Franklin made other interesting observations and arrived at conclusions related to chemical concepts and phenomena unusual for scientists of that time. A careful analysis of Franklin's article on wave damping can lead to discussions on different topics in chemistry, and may be an interesting manner to present chemical concepts in introductory chemistry courses.

  9. [The research of revision on herb properties in Shaoxing Ben cao].

    PubMed

    Liu, Yue; Zheng, Jin-Sheng

    2011-01-01

    Shaoxing Bencao, wrote by WANG Jixian in South Song dynasty (1159), is a classic Chinese medicine book which aims to revise herb properties described in former literature. There are 371 items in the book evaluating herb properties recorded in books about herbs. Keeping those the thought right, correcting those he thought wrong, complementing those missed and selecting better ones from those with disputes. He revised herb properties in 50.9% of all the items. Herb properties were evaluated mainly according to record and clinical practice with emphasis on property-effect (effect and adverse effect) relationship. Logical deduction was also used to deduce herb toxicity and quality according to herb flavor, nature, tastes and their growing environment. The book described in detail the influence of processing on the herb properties and toxicity. The evaluation methods in this book are of reference value for learning about the formation of knowledge of herb properties. PMID:21569699

  10. Tibbon, Jacob ben Machir ibn [known as Prophatius] (1236-1312)

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    Doctor, born in Marseilles, Spain (now France), a translator, mathematician and astronomer. He invented what is known as Jacob's quadrant, and the book in which he describes it contains a table of 11 stars used in the construction of the instrument. He wrote Luhot (Tables) a book of astronomical tables giving positions of stars at Paris. Tibbon's work was mentioned in DANTE's Divine Comedy and u...

  11. Observing Ben Wyckoff: From Basic Research to Programmed Instruction and Social Issues

    PubMed Central

    Escobar, Rogelio; Lattal, Kennon A

    2011-01-01

    L. Benjamin Wyckoff's seminal contributions to both psychological theory and application are the subject of this review. Wyckoff started his academic career as a graduate student at Indiana University, where he developed the observing-response procedure under the guidance of B. F. Skinner and C. J. Burke. At the University of Wisconsin–Madison, Wyckoff refined his mathematical theory of secondary reinforcement. This theory was the impetus for his creation of an electronic simulation of a rat running a T maze, one of the first “computer models” of learning. Wyckoff next went to Emory University, leaving there to help create two of the most successful companies dedicated to the advancement of programmed instruction and teaching machines: Teaching Machines, Inc. and the Human Development Institute. Wyckoff's involvement in these companies epitomizes the application of basic behavior-analytic principles in the development of technology to improve education and human relationships. The emergent picture of Wyckoff is that of a man who, through his research, professional work in educational applications of behavioral principles, and active involvement in the civil rights movement of the 1960s, was strongly committed to applying behavioral science to positively influence human behavior change. PMID:22532737

  12. Radiative 10Be(n, γ)11Be capture at thermal and astrophysical energies

    NASA Astrophysics Data System (ADS)

    Dubovichenko, S. B.; Dzhazairov-Kakhramanov, A. V.

    2016-09-01

    The modified potential cluster model with the forbidden states and the classification of states according to the Young tableaux, which are irreducible representations of permutation symmetric group SU(4), was used in this paper. Within the framework of this model the possibility of describing the experimental data available for the total reaction cross sections and the reaction rate of neutron radiative capture on 10Be at thermal and astrophysical energies has been shown.

  13. Addition of Astra-Ben 20 to Sequester Aflatoxin During Protein Extraction of Contaminated Peanut Meal

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Peanut meal is an excellent source of high quality protein; however, the relatively high aflatoxin concentrations typically associated with this commodity currently limit applications within the feed market, in addition to being prohibitive for any future food ingredient markets. Accordingly, the e...

  14. Ben's Perception of Space and Subitizing Activity: A Constructivist Teaching Experiment

    ERIC Educational Resources Information Center

    MacDonald, Beth L.

    2015-01-01

    This 22-session constructivist teaching experiment set out to investigate a preschool student's number understanding relative to his subitizing activity. Subitizing, a quick apprehension of the numerosity of a small set of items, has been found to characterize perceptual and conceptual processes students rely on as their understanding of number…

  15. A space maintainability experiment aboard the Ben Franklin submersible during the 30-day Gulf Stream drift mission.

    NASA Technical Reports Server (NTRS)

    Kappler, J. R.; May, C. B.

    1972-01-01

    In the summer of 1969, a deep submersible drifted for 30 days below the surface of the Gulf Stream, while operated by a six man crew. The main purpose of the mission was oceanographic research. The crew's activities and completely self-contained environment resembled those of a space station such as Skylab. Because of these similarities aspects of onboard vehicle maintenance during the actual conduct of a scientific mission were investigated. The maintainability study was accomplished in six distinct phases. Two useful plots of manpower distribution were developed. A maintenance action summary is presented in a table.

  16. ‘I Haue Ben Crised and Besy’: Illness and Resilience in the Fifteenth-Century Stonor Letters

    PubMed Central

    Thorpe, Deborah

    2016-01-01

    The modern and medieval meanings of words reporting ill health often bear little resemblance to one another. This article compares the use of ‘diseased’ and ‘sick’ in the fifteenth-century Stonor family letters. It examines the word ‘crased’, which implies physical ill health most directly, but also suggests emotional, psychological, or spiritual distress in female family members especially. The article then turns to the practical implications of poor health, asking how and why it affected the day-to-day concerns of the Stonors and their associates. It uncovers compelling evidence for resilience in the face of many and competing calls of duty. Finally, the article presents unique palaeographical evidence for the impact of illness, where a correspondent is so ‘seke’ that he can scarcely hold his pen.

  17. Microscopic analysis of 10,11Be elastic scattering on protons and 12C and breakup processes of 11Be within the 10Be+n cluster model

    NASA Astrophysics Data System (ADS)

    Spasova, K.; Lukyanov, V. K.; Kadrev, D. N.; Antonov, A. N.; Zemlyanaya, E. V.; Lukyanov, K. V.; Gaidarov, M. K.

    2016-06-01

    The elastic scattering cross-sections of 10,11Be on protons and 12C at energy E < 100 MeV/nucleon using microscopically calculated optical potentials (OP) are presented. The real OP is obtained by a folding procedure with effective NN interactions, while the imaginary OP is estimated within the high energy approximation (HEA). The spin-orbit part of the OP is also included. The characteristics of the breakup processes of 11Be on different nuclear targets are also considered. The cross-sections of diffractive breakup and stripping reactions of 11Be on 9Be, 93Nb, 181Ta and 238U at energy E = 63 MeV/nucleon and the longitudinal momentum distributions of 10Be fragments produced in the breakup of 11Be on these nuclei are presented. The results are in a good agreement with the available experimental data, in particular the obtained widths of about 50 MeV/c are closed to the empirical ones.

  18. Evaluation of Lateglacial temperatures in the Southern Alps of New Zealand based on glacier modelling at Irishman Stream, Ben Ohau Range

    NASA Astrophysics Data System (ADS)

    Doughty, Alice M.; Anderson, Brian M.; Mackintosh, Andrew N.; Kaplan, Michael R.; Vandergoes, Marcus J.; Barrell, David J. A.; Denton, George H.; Schaefer, Joerg M.; Chinn, Trevor J. H.; Putnam, Aaron E.

    2013-08-01

    Climate proxy records from the middle to high latitude Southern Hemisphere indicate that a Lateglacial (15,000-11,500 years ago) climate reversal, approximately coeval with the Antarctic Cold Reversal (ACR), interrupted a warming trend during deglaciation. In New Zealand, some palaeoclimate proxy records indicate a cool episode during the ACR (ca 14,500-12,500 years ago), while others do not express a significant change in climate. Recently published moraine maps and ages present an opportunity to improve the palaeoclimate interpretation through numerical modelling of glaciers. We use a coupled energy-balance and ice-flow model to quantify palaeoclimate from past glacier extent constrained by mapped and dated moraines in the headwaters of Irishman Stream, a high-elevation catchment in the Southern Alps. First, a suite of steady-state model runs is used to identify the temperature and precipitation forcing required to fit the modelled glacier to well-dated Lateglacial moraine crests. Second, time-dependent glacier simulations forced by a nearby proxy temperature record derived from chironomids are used to assess the fit with the glacial geomorphic record. Steady-state experiments using an optimal parameter set demonstrate that the conditions under which the 13,000 year old moraine formed were 2.3-3.2 °C colder than present with the range in temperature corresponding to a ±20% variance in precipitation relative to the present-day. This reconstructed climate change relative to the present-day corresponds to an equilibrium-line altitude of ca 2000 ± 40 m above sea level (asl), which is ca 400 m lower than present. Time-dependent simulations of glacier length produce ice advance to within 100 m of the 13,000 year old terminal moraine, indicating that the chironomid-based temperature forcing and moraine record provide consistent information about past climate. Our results, together with other climate proxy reconstructions from pollen records and marine sediment cores, support the notion that temperatures during the ACR in New Zealand were ˜2-3 °C cooler than today.

  19. Coffy, YouTube, and Uncle Ben: The Use of Film and New Media in the Teaching of African American Studies at the University of Hawai'i

    ERIC Educational Resources Information Center

    White, Elisa Joy

    2009-01-01

    In this article, the author discusses how she uses film and new media to "teach students to comprehend the complex historical, social, political, and cultural dimensions of the African American experience." The author uses D.W. Griffith's 1915 "Birth of a Nation," a number of "Blaxploitation" films, YouTube videos, and cultural tropes common to…

  20. TU-A-17A-02: In Memoriam of Ben Galkin: Virtual Tools for Validation of X-Ray Breast Imaging Systems

    SciTech Connect

    Myers, K; Bakic, P; Abbey, C; Kupinski, M; Mertelmeier, T

    2014-06-15

    This symposium will explore simulation methods for the preclinical evaluation of novel 3D and 4D x-ray breast imaging systems – the subject of AAPM taskgroup TG234. Given the complex design of modern imaging systems, simulations offer significant advantages over long and costly clinical studies in terms of reproducibility, reduced radiation exposures, a known reference standard, and the capability for studying patient and disease subpopulations through appropriate choice of simulation parameters. Our focus will be on testing the realism of software anthropomorphic phantoms and virtual clinical trials tools developed for the optimization and validation of breast imaging systems. The symposium will review the stateof- the-science, as well as the advantages and limitations of various approaches to testing realism of phantoms and simulated breast images. Approaches based upon the visual assessment of synthetic breast images by expert observers will be contrasted with approaches based upon comparing statistical properties between synthetic and clinical images. The role of observer models in the assessment of realism will be considered. Finally, an industry perspective will be presented, summarizing the role and importance of virtual tools and simulation methods in product development. The challenges and conditions that must be satisfied in order for computational modeling and simulation to play a significantly increased role in the design and evaluation of novel breast imaging systems will be addressed. Learning Objectives: Review the state-of-the science in testing realism of software anthropomorphic phantoms and virtual clinical trials tools; Compare approaches based upon the visual assessment by expert observers vs. the analysis of statistical properties of synthetic images; Discuss the role of observer models in the assessment of realism; Summarize the industry perspective to virtual methods for breast imaging.

  1. Biophysical processes in fibrosis. Comment on: "Towards a unified approach in the modeling of fibrosis: A review with research perspectives" by Carlo Bianca and Martine Ben Amar

    NASA Astrophysics Data System (ADS)

    La Porta, Caterina A. M.; Zapperi, Stefano

    2016-07-01

    The process of inflammation tries to protect the body after an injury due to biological causes such as the presence of pathogens or chemicals, or to physical processes such as burns or cuts. The biological rationale for this process has the main goal of eliminating the cause of the injury and then repairing the damaged tissues. We can distinguish two kinds of inflammations: acute and chronic. In acute inflammation, a series of events involving the local vascular systems, the immune system and various cells within the injured tissue work together to eradicate the harmful stimuli. If the inflammation does not resolve the problem, it can evolve into a chronic inflammation, where the type of cells involved changes and there is a simultaneous destruction and healing of the tissue from the inflammation process.

  2. U.S. ARMY HUMAN FACTORS RESEARCH AND DEVELOPMENT ANNUAL CONFERENCE, INDIVIDUAL AND SMALL-UNIT TRAINING FOR COMBAT OPERATIONS (12TH, FORT BENNING, GEORGIA, OCTOBER 1966).

    ERIC Educational Resources Information Center

    JACOBS, T.O.; AND OTHERS

    RESEARCH IN THE AREA OF MILITARY TRAINING AND TRAINING METHODS WAS REVIEWED AND ASSESSED FOR (1) ITS RELEVANCE TO MODERN COMBAT OPERATIONS (IDENTIFICATION OF COMBAT TASKS, DEVELOPMENT OF SKILL TRAINING, AND EVALUATION) AND (2) ITS EFFICIENCY (REDUCED COST AND TIME AND INCREASED TRAINEE PROFICIENCY, OR BOTH). CASES OF EFFECTIVE RESEARCH IN USE OF…

  3. Ben's Model: A Multivocal Synthesis for an Evidence-Based, Family-Centered Program Planning Model for Young Children with Autism

    ERIC Educational Resources Information Center

    Music, Amber D.

    2013-01-01

    Every year, the prevalence of children with autism increases, and community programs should be prepared to address the needs of this population. Comprehensive Treatment Models (CTMs) are in place to help serve children with autism, but the components of these programs are diverse. Furthermore, recommendations from prominent organizations such as…

  4. Granulocyte colony stimulating factor (G-CSF) can allow treatment with clozapine in a patient with severe benign ethnic neutropaenia (BEN): a case report.

    PubMed

    Spencer, Benjamin W J; Williams, Hugh R J; Gee, Siobhan H; Whiskey, Eromona; Rodrigues, Joseph P; Mijovic, Aleksandar; MacCabe, James H

    2012-09-01

    Clozapine is the treatment of choice for treatment-resistant schizophrenia, but it is associated with a risk of neutropaenia and agranulocytosis. Clozapine use is regulated by mandatory blood monitoring in the UK, requiring cessation of treatment should the absolute neutrophil count (ANC) drop below specified values. Benign reductions in the ANC in non-white populations are common, and this can preclude a patient from receiving treatment with clozapine. A diagnosis of benign ethnic neutropaenia can reduce these treatment restrictions (UK specific), but the degree of neutropaenia can be significant enough to still prevent treatment. In this report, we show that response to granulocyte colony stimulating factor (G-CSF) may be quite variable and difficult to predict, but with careful monitoring it can be used to increase the ANC count and allow continued treatment with clozapine. PMID:22719015

  5. Variation of a benthic heterotrophic bacteria community with different respiratory metabolisms in Coyuca de Benítez coastal lagoon (Guerrero, Mexico).

    PubMed

    Ferrara-Guerrero, María Jesús; Castellanos-Páez, María Elena; Garza-Mouriño, Gabriela

    2007-03-01

    The fluctuations of the number, biomass and composition of the heterotrophic community were studied daily for two days, according to depth, pH, Eh, O2 and organic carbon concentration within a zone of the canal between the Coyuca de Benitez lagoon (Guerrero, Mexico) and the coastal waters. At the three moments of the day studied (6 am, 2 pm and 10 pm), the oxygen concentrations in the overlying water and in the superficial sediment layer were near air-saturation in the diurnal samplings (582 microM at 6 am and 665 microM at 2 pm), and sub-satured during the night (158 microM). In the sediments, the models of vertical distribution of Eh and organic carbon distributions were very irregular due to the bio-perturbation of the benthic, meio- and macrofauna, whose activity allows the superficial organic carbon to migrate towards sediment deeper layers. Vertical distribution of the different viable bacteria populations seems to be related to the hydrodynamic patterns of the communicating canal and sediments heterogeneity. In the sediment column, the heterotrophic bacteria total number varied from 6.8 to 20.3 x 108 cells cm(-3). The highest heterotrophic bacterial biomass values were encountered during the diurnal samplings (39.2 microgC.l(-1) at 6 am and 34.4 microgC.(l(-1) at 2 pm) and the lowest during the night (9.7 microgC.l(-1). The fluctuations of viable heterotrophic bacteria populations with different respiratory metabolisms (aerobic, microaerophilic and anaerobic) can be explained by the existence of suboxic microniches that appear when particles of sediment are resuspended due to the water circulation and the benthic infauna excavating activity, that allows the supernatant water oxygen to penetrate through its galleries towards deeper sediment zones. The statistical analysis (Multiple lineal regression model r2 > or = 0.5) showed that the on the whole, the hydrological parameters are not influence over the bacterial number and bacterial biomass distribution (r2 < or = 0.5), Nevertheless, the variations of the heterotrophic bacteria community observed in the two days sampling, seem to be governed (with F-values of 0.6 to 0.9) by the irregular flows of bio-available organic material and the sediment porosity. PMID:18457123

  6. Promoting healthy eating, active play and sustainability consciousness in early childhood curricula, addressing the Ben10™ problem: a randomised control trial

    PubMed Central

    2014-01-01

    Background This paper details the research protocol for a study funded by the Australian Research Council. An integrated approach towards helping young children respond to the significant pressures of ‘360 degree marketing’ on their food choices, levels of active play, and sustainability consciousness via the early childhood curriculum is lacking. The overall goal of this study is to evaluate the efficacy of curriculum interventions that educators design when using a pedagogical communication strategy on children’s knowledge about healthy eating, active play and the sustainability consequences of their toy food and toy selections. Methods/Design This cluster-randomised trial will be conducted with 300, 4 to 5 year-old children attending pre-school. Early childhood educators will develop a curriculum intervention using a pedagogical communication strategy that integrates content knowledge about healthy eating, active play and sustainability consciousness and deliver this to their pre-school class. Children will be interviewed about their knowledge of healthy eating, active play and the sustainability consequences of their food and toy selections. Parents will complete an Eating and Physical Activity Questionnaire rating their children’s food preferences, digital media viewing and physical activity habits. All measures will be administered at baseline, the end of the intervention and 6 months post intervention. Informed consent will be obtained from all parents and the pre-school classes will be allocated randomly to the intervention or wait-list control group. Discussion This study is the first to utilise an integrated pedagogical communication strategy developed specifically for early childhood educators focusing on children’s healthy eating, active play, and sustainability consciousness. The significance of the early childhood period, for young children’s learning about healthy eating, active play and sustainability, is now unquestioned. The specific teaching and learning practices used by early childhood educators, as part of the intervention program, will incorporate a sociocultural perspective on learning; this perspective emphasises building on the play interests of children, that are experienced within the family and home context, as a basis for curriculum provision. Trial Registration Australian New Zealand Clinical Trials Registry ACTRN12614000363684: Date registered: 07/04/2014 PMID:24888732

  7. Association analysis using SSR markers to identify QTL for seed protein content in soybeans

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Five soybean [Glycine max (L.) Merr.] germplasm lines were developed by the Georgia Agricultural Experiment Stations and released in 2005: G95-Ben335 (PI644042), G95-Ben 1818 (PI 644043), G95-Ben2403 (PI 6444044), G95-Ben2448 (PI644045), and G95-Ben4123 (PI644046). They were selected within the prod...

  8. PHOTOCOPY OF DRAWING (from Cultural Resources Management Program for the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PHOTOCOPY OF DRAWING (from Cultural Resources Management Program for the Environment Management Division, Directorate of Public Works, Fort Benning, Georgia) Delineator unknown. GARAGES - Fort Benning, Building No. 864, 7325 Miller Loop, Main Post, Fort Benning Military Reservation, Chattahoochee County, GA

  9. Registration of five soybean germplasm lines selected within the cultivar ‘Benning’ differing in seed and agronomic traits

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Five soybean [Glycine max (L.) Merr.] germplasm lines were developed by the Georgia Agricultural Experiment Stations and released in 2005: G95-Ben335 (Reg. No. GP-332, PI 644042), G95-Ben1818 (Reg. No. GP-333, PI 644043), G95-Ben2403 (Reg. No. GP-334, PI 644044), G95-Ben2448 (Reg. No. GP-335, PI 644...

  10. Assisting Students Struggling with Mathematics: Response to Intervention (RtI) for Elementary and Middle Schools. Q&A with Ben Clarke Ph.D and Paul Riccomini, Ph.D. REL Mid-Atlantic Event

    ERIC Educational Resources Information Center

    Clarke, Ben; Riccomini, Paul

    2013-01-01

    This REL Mid-Atlantic Event focused on effective strategies for screening, instruction, and differentiation of instruction as part of math RtI implementation. The Q&A presented in this document address the questions participants had for Dr. Clarke and Dr. Riccomini following the event. Dr. Clarke's and Dr. Riccomini's PowerPoint presentations…

  11. Validation of multi-scale models for fibrosis. Comment on "Towards a unified approach in the modeling of fibrosis: A review with research perspectives" by M. Ben Amar and C. Bianca

    NASA Astrophysics Data System (ADS)

    Eftimie, Raluca

    2016-07-01

    Over the last few decades, medical research has started to emphasise the need for an integrative approach that could unravel the progression of various diseases across different spatial and temporal scales, and the links between the different phases of disease progression [2,6]. Among these diseases, the fibroproliferative disorders are a leading cause of morbidity and mortality by affecting tissues and organ systems [11], and thus investigating and understanding the common mechanisms behind fibrogenesis might lead to the development of new therapies [6,9].

  12. Asymptotic methods as multiscale methods for fibrosis. Comment on "Towards a unified approach in the modeling of fibrosis: A review with research perspectives" by Martine Ben Amar and Carlo Bianca

    NASA Astrophysics Data System (ADS)

    Dogbe, Christian

    2016-07-01

    The definition of multiscale models for biological system is the new challenge of the last and this century. In particular the construction of methods which allow to link the dynamics described at mesoscopic scale with the dynamics at macroscopic scale has been performed in the last century in the kinetic theory of gas [1-5] and it is of great interest also in this century for what concern the applications [6-9]. The most famous method for deriving the macroscopic description from kinetic equation is based on the definition of the parabolic/diffusive and hyperbolic scalings and subsequently on the so-called small Knudsen number (proportional to the mean free path) limit.

  13. Creating a multi-gas proxy for Delta 14C and atmospheric fossil fuel-CO2. Kevin Coakley, John Miller , Scott Lehman, Stephen Montzka, Colm Sweeney, Arlyn Andrews , Ben Miller

    NASA Astrophysics Data System (ADS)

    Coakley, K. J.; Miller, J. B.; Lehman, S.; Montzka, S. A.; Andrews, A. E.; Miller, B. R.

    2013-12-01

    The C14:C12 ratio of atmospheric CO2 (expressed as Delta 14C) is the gold standard measurement to derive the portion of observed atmospheric CO2 gradients resulting from combustion of fossil fuels (CO2-ff). This is because fossil fuels are devoid of 14C, unlike all other sources and sinks that impact atmospheric Delta14C. With enough 14C measurements, independent, 'top-down', estimation of US fossil fuel-CO2 emissions should be possible. However, our ability to make carbon-14 measurements is severely constrained by cost, accessibility to accelerator mass spectrometers (AMS) and the volume of air required to make high precision (~0.2 %) measurements of 14CO2 (mixing ratio is ~ 4e-16 mol/mol). Thus, Delta 14C is currently measured in only a small subset of NOAA/ESRL Global Monitoring Division (GMD) tall-tower and aircraft air samples. Here, we present a Projection Pursuit Regression (PPR) model to predict CO2-ff measured at different times and altitudes in terms of surrogate gases that are more widespread and relatively inexpensive to measure. This method would, in effect, allow expansion of Delta 14C measurements by factor of ~3 or 4 throughout North America. To create a proxy for CO2-ff, we take advantage of the observed correlations between (Delta 14C-derrived) CO2-ff and regional-scale enhancements of a wide array of anthropogenic gases, like CO, SF6, and halo- and hydro-carbons. We select the complexity and form of the PPR model by cross validation where validation data prediction error is minimized. In cross validation, the prediction model is based on the training data and not the validation data. We quantify prediction model performance with test data excluded from the model development process. According to cross validation, the PPR model is superior to a simpler linear model. Comparison with test CO2-ff data shows that CO2-ff can be predicted with a root mean square error of 1.1 ppm, only slightly higher than the Delta 14C-precision limit for CO2-ff of 1 ppm. Applying the PPR model to the large NOAA/ESRL/GMD database of surrogate gases, we can create a large set of synthetic CO2-ff data for the US. Finally, we will discuss the application of this large data set of lower-precision CO2-ff to top down determination of US fossil fuel CO2 emissions by presenting results from an Observation System Simulation Experiment (OSSE).

  14. Cells distribution in the modeling of fibrosis. Comment on "Towards a unified approach in the modeling of fibrosis: A review with research perspectives" by Martine Ben Amar and Carlo Bianca

    NASA Astrophysics Data System (ADS)

    Abdel-Aty, Mahmoud

    2016-07-01

    The modeling of a complex system requires the analysis of all microscopic constituents and in particular of their interactions [1]. The interest in this research field has increased considering also recent developments in the information sciences. However interaction among scholars working in various fields of the applied sciences can be considered the true motor for the definition of a general framework for the analysis of complex systems. In particular biological systems constitute the platform where many scientists have decided to collaborate in order to gain a global description of the system. Among others, cancer-immune system competition (see [2] and the review papers [3,4]) has attracted much attention.

  15. Medicines Management for Nurses at a Glance Young Simon and Pitcher Ben Medicines Management for Nurses at a Glance 120pp £26.99 Wiley Blackwell 9781118840726 1118840720 [Formula: see text].

    PubMed

    2016-06-01

    THIS BOOK is a general introduction to topics related to medicines management, rather than an in-depth discussion. However, it provides a good starting point for expanding knowledge of medicines management. PMID:27246420

  16. The transport of drug in fibrosis. Comment on "Towards a unified approach in the modeling of fibrosis: A review with research perspectives" by Martine Ben Amar and Carlo Bianca

    NASA Astrophysics Data System (ADS)

    Ivancevic, Vladimir

    2016-07-01

    The topic of the review article [1] is the derivation of a multiscale paradigm for the modeling of fibrosis. Firstly, the biological process of the physiological and pathological fibrosis including therapeutical actions is reviewed. Fibrosis can be a consequence of tissue damage, infections and autoimmune diseases, foreign material, tumors. Some questions regarding the pathogenesis, progression and possible regression of fibrosis are lacking. At each scale of observation, different theoretical tools coming from computational, mathematical and physical biology have been proposed. However a complete framework that takes into account the different mechanisms occurring at different scales is still missing. Therefore with the main aim to define a multiscale approach for the modeling of fibrosis, the authors of [1] have presented different top-down and bottom-up approaches that have been developed in the literature. Specifically, their description refers to models for fibrosis diseases based on ordinary and partial differential equation, agents [2], thermostatted kinetic theory [3-5], coarse-grained structures [6-8] and constitutive laws for fibrous collagen networks [9]. A critical analysis has been addressed for all frameworks discussed in the paper. Open problems and future research directions referring to both biological and modeling insight of fibrosis are presented. The paper concludes with the ambitious aim of a multiscale model.

  17. Control and optimization in the modeling of fibrosis. Comment on "Towards a unified approach in the modeling of fibrosis: A review with research perspectives" by Martine Ben Amar and Carlo Bianca

    NASA Astrophysics Data System (ADS)

    Sivasundaram, Seenith

    2016-07-01

    The review paper [1] is devoted to the survey of different structures that have been developed for the modeling and analysis of various types of fibrosis. Biomathematics, bioinformatics, biomechanics and biophysics modeling have been treated by means of a brief description of the different models developed. The review is impressive and clearly written, addressed to a reader interested not only in the theoretical modeling but also in the biological description. The models have been described without recurring to technical statements or mathematical equations thus allowing the non-specialist reader to understand what framework is more suitable at a certain observation scale. The review [1] concludes with the possibility to develop a multiscale approach considering also the definition of a therapeutical strategy for pathological fibrosis. In particular the control and optimization of therapeutics action is an important issue and this article aims at commenting on this topic.

  18. Multiscale modeling of fibrosis - What's next? Reply to Comments on "Towards a unified approach in the modeling of fibrosis: A review with research perspective" by Martine Ben Amar and Carlo Bianca

    NASA Astrophysics Data System (ADS)

    Ben Amar, Martine; Bianca, Carlo

    2016-07-01

    Following the commentary articles on the review [1], this reply aims at providing further issues on the possibility to develop a multiscale approach for the modeling of physiological and pathological fibrosis. Specifically this manuscript is devoted to the capability to employ new theoretical frameworks of the biomathematics, biophysics and bioinformatics for the derivation of a specific multiscale model including the possibility to validate the related model with experimental and empirical data. In particular comments on the mathematical control, frameworks with fractional-order, time delay, asymptotic methods, transport of drugs open the door to future investigations.

  19. Medicines Management for Nurses at a Glance Young Simon and Pitcher Ben Medicines Management for Nurses at a Glance 120pp £26.99 Wiley Blackwell 9781118840726 1118840720 [Formula: see text].

    PubMed

    2016-05-27

    THIS PUBLICATION presents a general introduction to medicines management rather than an in-depth discussion. However, it is a good starting point for expanding your knowledge on the subject. PMID:27231070

  20. BOILER, LOCATED IN BACK ROOM OF OYSTER SHUCKING BUILDING. STEAM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    BOILER, LOCATED IN BACK ROOM OF OYSTER SHUCKING BUILDING. STEAM WAS USED IN OYSTER PROCESSING, FOR EXAMPLE IN STERILIZING EQUIPMENT. - F. & H. Benning Company, 1014 Benning Road, Galesville, Anne Arundel County, MD

  1. DETAIL OF SPARE CONICAL CRUSHER AND GRINDING BURR WHEELS REMOVED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    DETAIL OF SPARE CONICAL CRUSHER AND GRINDING BURR WHEELS REMOVED FROM THE MILLING MACHINE. - F. & H. Benning Company Oyster Mill, 14430 Solomons Island Road (moved from 1014 Benning Road, Galesville, Anne Arundel County, Maryland), Solomons, Calvert County, MD

  2. Currants

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Descriptions of four newly released black currant (Ribes nigrum L.) cultivars are presented. Three of the cultivars are from Scotland: Ben Dorain, Ben Avon, and Big Ben. The fourth, Cancanska Crna, is from Yugoslavia . Each of these black currants have high vitamin C and other antioxidant compounds....

  3. MicroRNA Profiling in Patients with Upper Tract Urothelial Carcinoma Associated with Balkan Endemic Nephropathy.

    PubMed

    Popovska-Jankovic, Katerina; Noveski, Predrag; Jankovic-Velickovic, Ljubinka; Stojnev, Slavica; Cukuranovic, Rade; Stefanovic, Vladisav; Toncheva, Draga; Staneva, Rada; Polenakovic, Momir; Plaseska-Karanfilska, Dijana

    2016-01-01

    Balkan endemic nephropathy (BEN) is a disease that affects people that live in the alluvial plains along the tributaries of the Danube River in the Balkan region. BEN is a chronic tubulointerstitial disease with a slow progression to terminal renal failure and has strong association with upper tract urothelial carcinoma (UTUC). There are several hypotheses about the etiology of BEN, but only the toxic effect of aristolochic acid has been confirmed as a risk factor in the occurrence of the disease. Aberrantly expressed miRNAs have been shown to be associated with many types of cancers. A number of studies have investigated the expression of microRNAs in urothelial carcinoma, mainly on urothelial bladder cancer, and only a few have included patients with UTUC. Here we present the first study of microRNA profiling in UTUC tissues from patients with BEN (BEN-UTUC) and patients with UTUC from nonendemic Balkan regions (non-BEN-UTUC) in comparison to normal kidney tissues. We found 10 miRNAs that were differentially expressed in patients with BEN-UTUC and 15 miRNAs in patients with non-BEN-UTUC. miRNA signature determined in BEN-UTUC patients differs from the non-BEN-UTUC patients; only miR-205-5p was mutual in both groups. PMID:27218105

  4. Removal of rhodamine B using iron-pillared bentonite.

    PubMed

    Hou, Mei-Fang; Ma, Cai-Xia; Zhang, Wei-De; Tang, Xiao-Yan; Fan, Yan-Ning; Wan, Hong-Fu

    2011-02-28

    The iron-pillared bentonite (Fe-Ben) was prepared by ion-exchange using the natural bentonite (GZ-Ben) from Gaozhou, China, at room temperature without calcination. Both Fe-Ben and GZ-Ben were characterized by X-ray diffraction, N(2) adsorption and Fourier transform infrared spectroscopy. The results show that the d(001) value and surface area of the bentonite material increased after iron pillaring. Fe-Ben adsorbed much more Rhodamine B (RhB) than GZ-Ben, which can be ascribed to the special surface properties and large surface area of Fe-Ben. The optimum pH value for the adsorption of RhB on Fe-Ben is 5.0. The adsorption of RhB onto Fe-Ben can be well described by the pseudo-second-order kinetic model and the intraparticle diffusion kinetic model. The adsorption isotherm of RhB onto Fe-Ben matches well with the Langmuir model. PMID:21168960

  5. MicroRNA Profiling in Patients with Upper Tract Urothelial Carcinoma Associated with Balkan Endemic Nephropathy

    PubMed Central

    Popovska-Jankovic, Katerina; Noveski, Predrag; Jankovic-Velickovic, Ljubinka; Stojnev, Slavica; Cukuranovic, Rade; Stefanovic, Vladisav; Toncheva, Draga; Staneva, Rada; Polenakovic, Momir; Plaseska-Karanfilska, Dijana

    2016-01-01

    Balkan endemic nephropathy (BEN) is a disease that affects people that live in the alluvial plains along the tributaries of the Danube River in the Balkan region. BEN is a chronic tubulointerstitial disease with a slow progression to terminal renal failure and has strong association with upper tract urothelial carcinoma (UTUC). There are several hypotheses about the etiology of BEN, but only the toxic effect of aristolochic acid has been confirmed as a risk factor in the occurrence of the disease. Aberrantly expressed miRNAs have been shown to be associated with many types of cancers. A number of studies have investigated the expression of microRNAs in urothelial carcinoma, mainly on urothelial bladder cancer, and only a few have included patients with UTUC. Here we present the first study of microRNA profiling in UTUC tissues from patients with BEN (BEN-UTUC) and patients with UTUC from nonendemic Balkan regions (non-BEN-UTUC) in comparison to normal kidney tissues. We found 10 miRNAs that were differentially expressed in patients with BEN-UTUC and 15 miRNAs in patients with non-BEN-UTUC. miRNA signature determined in BEN-UTUC patients differs from the non-BEN-UTUC patients; only miR-205-5p was mutual in both groups. PMID:27218105

  6. Resting State Brain Entropy Alterations in Relapsing Remitting Multiple Sclerosis

    PubMed Central

    Zhou, Fuqing; Zhuang, Ying; Gong, Honghan; Zhan, Jie; Grossman, Murray; Wang, Ze

    2016-01-01

    Brain entropy (BEN) mapping provides a novel approach to characterize brain temporal dynamics, a key feature of human brain. Using resting state functional magnetic resonance imaging (rsfMRI), reliable and spatially distributed BEN patterns have been identified in normal brain, suggesting a potential use in clinical populations since temporal brain dynamics and entropy may be altered in disease conditions. The purpose of this study was to characterize BEN in multiple sclerosis (MS), a neurodegenerative disease that affects millions of people. Since currently there is no cure for MS, developing treatment or medication that can slow down its progression represents a high research priority, for which validating a brain marker sensitive to disease and the related functional impairments is essential. Because MS can start long time before any measurable symptoms and structural deficits, assessing the dynamic brain activity and correspondingly BEN may provide a critical way to study MS and its progression. Because BEN is new to MS, we aimed to assess BEN alterations in the relapsing-remitting MS (RRMS) patients using a patient versus control design, to examine the correlation of BEN to clinical measurements, and to check the correlation of BEN to structural brain measures which have been more often used in MS studies. As compared to controls, RRMS patients showed increased BEN in motor areas, executive control area, spatial coordinating area, and memory system. Increased BEN was related to greater disease severity as measured by the expanded disability status scale (EDSS) and greater tissue damage as indicated by the mean diffusivity. Patients also showed decreased BEN in other places, which was associated with less disability or fatigue, indicating a disease-related BEN re-distribution. Our results suggest BEN as a novel and useful tool for characterizing RRMS. PMID:26727514

  7. Resting State Brain Entropy Alterations in Relapsing Remitting Multiple Sclerosis.

    PubMed

    Zhou, Fuqing; Zhuang, Ying; Gong, Honghan; Zhan, Jie; Grossman, Murray; Wang, Ze

    2016-01-01

    Brain entropy (BEN) mapping provides a novel approach to characterize brain temporal dynamics, a key feature of human brain. Using resting state functional magnetic resonance imaging (rsfMRI), reliable and spatially distributed BEN patterns have been identified in normal brain, suggesting a potential use in clinical populations since temporal brain dynamics and entropy may be altered in disease conditions. The purpose of this study was to characterize BEN in multiple sclerosis (MS), a neurodegenerative disease that affects millions of people. Since currently there is no cure for MS, developing treatment or medication that can slow down its progression represents a high research priority, for which validating a brain marker sensitive to disease and the related functional impairments is essential. Because MS can start long time before any measurable symptoms and structural deficits, assessing the dynamic brain activity and correspondingly BEN may provide a critical way to study MS and its progression. Because BEN is new to MS, we aimed to assess BEN alterations in the relapsing-remitting MS (RRMS) patients using a patient versus control design, to examine the correlation of BEN to clinical measurements, and to check the correlation of BEN to structural brain measures which have been more often used in MS studies. As compared to controls, RRMS patients showed increased BEN in motor areas, executive control area, spatial coordinating area, and memory system. Increased BEN was related to greater disease severity as measured by the expanded disability status scale (EDSS) and greater tissue damage as indicated by the mean diffusivity. Patients also showed decreased BEN in other places, which was associated with less disability or fatigue, indicating a disease-related BEN re-distribution. Our results suggest BEN as a novel and useful tool for characterizing RRMS. PMID:26727514

  8. Common Polymorphisms in GSTA1, GSTM1 and GSTT1 Are Associated with Susceptibility to Urinary Bladder Cancer in Individuals from Balkan Endemic Nephropathy Areas of Serbia.

    PubMed

    Matic, Marija; Dragicevic, Biljana; Pekmezovic, Tatjana; Suvakov, Sonja; Savic-Radojevic, Ana; Pljesa-Ercegovac, Marija; Dragicevic, Dejan; Smiljic, Jelena; Simic, Tatjana

    2016-01-01

    Balkan endemic nephropathy (BEN) is a chronic familial form of interstitial nephritis that might eventually lead to end stage renal disease. This nephropathy affects individuals living along of the Danube River and its tributaries in Serbia, Bosnia, Croatia, Bulgaria and Romania. The increased incidence of urinary tract tumors in the BEN areas is well described, but its specific genetic predisposition is still unclear. Certain nephrocarcinogenic compounds, including those associated with BEN, are metabolized by glutathione S-transferase (GST) superfamily of phase II detoxication enzymes. Importantly, the GST-mediated detoxification may result in formation of more toxic compounds. We examined the association of common GST polymorphisms and bladder cancer (BC) risk in individuals from BEN areas in Serbia. A hospital-based case-control study included 201 BC cases (67 from BEN region) and 122 controls. Each polymorphism was identified by a PCR-based method. Individuals from BEN region with low-expression GSTA1 genotype (AB+BB) exhibited a 2.6-fold higher BC risk compared to those with GSTA1 (AA) genotype who were from non-BEN region (OR = 2.60, p = 0.015). In contrast, carriers of GSTM1-active genotype from BEN region had a 2.9-fold increased BC risk compared to those with GSTM1-active genotype from non-BEN region (OR = 2.90, p = 0.010). Likewise, carriers with GSTT1-active genotype from BEN region exhibited 2.1-fold higher BC risk compared to those from non-BEN region with GSTT1-active genotype (OR = 2.10, p = 0.027). Thus, common polymorphisms in GSTA1, GSTM1 and GSTT1 are associated with susceptibility to BC in individuals from BEN areas of Serbia. PMID:27568660

  9. Identification and Clinical Characterization of Children With Benign Ethnic Neutropenia.

    PubMed

    Ortiz, Michael V; Meier, Emily R; Hsieh, Matthew M

    2016-04-01

    Benign ethnic neutropenia (BEN) is an asymptomatic condition reported in adults of African and Middle Eastern descent. The clinical description in children is currently lacking. In our urban outpatient pediatric hematology clinic, the median neutrophil count of children with BEN was lower than previous reports in adults at 893×10 cells/L, but increased with older age. There was an equal male to female ratio and 24% of our BEN children reported ethnicities other than African or Middle Eastern. Children with BEN had a clinical course comparable with other healthy children including otherwise normal blood counts, except for mild anemia. PMID:26925714

  10. Offspring of parents with Balkan Endemic Nephropathy have higher C-reactive protein levels suggestive of inflammatory processes: a longitudinal study

    PubMed Central

    2009-01-01

    Background Despite the characteristic extensive tubulointerstitial fibrosis, Balkan Endemic Nephropathy (BEN) is usually considered a non-inflammatory disease. Methods We examined a marker of inflammation, C-reactive protein (CRP), in the offspring of patients with BEN, a population at risk for BEN, prior to development of established disease to determine if an inflammatory process could be identified in the early stages of the disease. In 2003/04, 102 adult offspring whose parents had BEN and a control group of 99 adult offspring of non-BEN patients were enrolled in this prospective study. This cohort was re-examined yearly for four consecutive years. Levels of serum CRP were measured in years 3 and 4 and compared between groups. The data were analyzed with mixed models. Results Compared to controls, offspring of BEN parents had statistically higher CRP levels in two consecutive years, suggestive of early inflammatory reactivity. Whenever the mother was affected by BEN (both parents, or mother only), serum CRP was significantly increased, but not if only the father had BEN. CRP was inversely related to kidney cortex width but not to markers or renal function. Conclusion Early stages of BEN may involve inflammatory processes. The observation of a maternal involvement supports the concept of fetal programming, which has been implicated in the pathogenesis of other chronic kidney diseases. PMID:19400955

  11. Suitability of Soybean Meal from Insect-Resistant Soybeans for Broiler Chickens.

    PubMed

    Ortega, María A; Davis, Adam J; Boerma, H Roger; Parrott, Wayne A

    2016-03-23

    Benning(M) and Benning(MGH) are near-isogenic lines (NILs) of the soybean cultivar Benning, which contain insect-resistance quantitative trait loci (QTLs) from the soybean accession PI 229358. Benning(M) contains QTL-M, which confers antibiosis and antixenosis. In addition to QTL-M, Benning(MGH) contains QTL-G, which confers antibiosis, and QTL-H, which confers antixenosis. Soybean meal was produced from Benning and the NILs. Nutritional composition, digestible amino acid content, and nitrogen-corrected true metabolizable energy (TMEN) were equivalent among soybean meals. A 21-day broiler feeding trial was carried out to determine if the QTLs affect soybean meal quality. Weight gain and feed-to-gain ratio were evaluated. No biologically significant differences were detected for broilers fed Benning, Benning(M), and Benning(MGH). This demonstrates that soybean meal produced from the insect-resistant NILs is equivalent to soybean meal produced from their non-insect-resistant parent cultivar for broiler weight gain. PMID:26949980

  12. Correlates of the MMPI-2-RF in a College Setting

    ERIC Educational Resources Information Center

    Forbey, Johnathan D.; Lee, Tayla T. C.; Handel, Richard W.

    2010-01-01

    The current study examined empirical correlates of scores on Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF; A. Tellegen & Y. S. Ben-Porath, 2008; Y. S. Ben-Porath & A. Tellegen, 2008) scales in a college setting. The MMPI-2-RF and six criterion measures (assessing anger, assertiveness, sex roles, cognitive failures,…

  13. INTERIOR VIEW WITH GRINDING MILL AND CONVEYOR EXTENDING UP TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    INTERIOR VIEW WITH GRINDING MILL AND CONVEYOR EXTENDING UP TO SORTING DRUM. DRIVE ENGINE AT LOWER LEFT. RADIATOR FOR ENGINE AT RIGHT. - F. & H. Benning Company Oyster Mill, 14430 Solomons Island Road (moved from 1014 Benning Road, Galesville, Anne Arundel County, Maryland), Solomons, Calvert County, MD

  14. Hyper-resting brain entropy within chronic smokers and its moderation by Sex

    PubMed Central

    Li, Zhengjun; Fang, Zhuo; Hager, Nathan; Rao, Hengyi; Wang, Ze

    2016-01-01

    Cigarette smoking is a chronic relapsing brain disorder, and remains a premier cause of morbidity and mortality. Functional neuroimaging has been used to assess differences in the mean strength of brain activity in smokers’ brains, however less is known about the temporal dynamics within smokers’ brains. Temporal dynamics is a key feature of a dynamic system such as the brain, and may carry information critical to understanding the brain mechanisms underlying cigarette smoking. We measured the temporal dynamics of brain activity using brain entropy (BEN) mapping and compared BEN between chronic non-deprived smokers and non-smoking controls. Because of the known sex differences in neural and behavioral smoking characteristics, comparisons were also made between males and females. Associations between BEN and smoking related clinical measures were assessed in smokers. Our data showed globally higher BEN in chronic smokers compared to controls. The escalated BEN was associated with more years of smoking in the right limbic area and frontal region. Female nonsmokers showed higher BEN than male nonsmokers in prefrontal cortex, insula, and precuneus, but the BEN sex difference in smokers was less pronounced. These findings suggest that BEN mapping may provide a useful tool for probing brain mechanisms related to smoking. PMID:27377552

  15. Comparative 1H NMR Metabolomic Urinalysis of People Diagnosed with Balkan Endemic Nephropathy, and Healthy Subjects, in Romania and Bulgaria: A Pilot Study

    PubMed Central

    Mantle, Peter; Modalca, Mirela; Nicholls, Andrew; Tatu, Calin; Tatu, Diana; Toncheva, Draga

    2011-01-01

    1H NMR spectroscopy of urine has been applied to exploring metabolomic differences between people diagnosed with Balkan endemic nephropathy (BEN), and treated by haemodialysis, and those without overt renal disease in Romania and Bulgaria. Convenience sampling was made from patients receiving haemodialysis in hospital and healthy controls in their village. Principal component analysis clustered healthy controls from both countries together. Bulgarian BEN patients clustered separately from controls, though in the same space. However, Romanian BEN patients not only also clustered away from controls but also clustered separately from the BEN patients in Bulgaria. Notably, the urinary metabolomic data of two people sampled as Romanian controls clustered within the Romanian BEN group. One of these had been suspected of incipient symptoms of BEN at the time of selection as a ‘healthy’ control. This implies, at first sight, that metabolomic analysis can be predictive of impending morbidity before conventional criteria can diagnose BEN. Separate clustering of BEN patients from Romania and Bulgaria could indicate difference in aetiology of this particular silent renal atrophy in different geographic foci across the Balkans. PMID:22069742

  16. College? No Thanks, Mom and Dad

    ERIC Educational Resources Information Center

    Ruark, Jennifer

    2009-01-01

    Robin Wagner, director of the library at Gettysburg College, remembers a few years ago when her son, Ben, was a high-school senior. While all his friends were talking about their college plans, Ben, who had been accepted to the University of Pittsburgh's engineering program, refused to return the offer card. On the band-room whiteboard where kids…

  17. VIEW ALONG RAW MATERIAL CONVEYOR AT RIGHT WITH CRUSHED SHELL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW ALONG RAW MATERIAL CONVEYOR AT RIGHT WITH CRUSHED SHELL CONVEYOR ABOVE. ENGINE AND RADIATOR AT LOWER LEFT. - F. & H. Benning Company Oyster Mill, 14430 Solomons Island Road (moved from 1014 Benning Road, Galesville, Anne Arundel County, Maryland), Solomons, Calvert County, MD

  18. List 47: currants

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This summary presents the descriptions of two newly released black currant (Ribes nigrum L.) for the List of New Fruit and Nut Cultivars. These black currant cultivars were just released and now hold US plant patents. The cultivars are 'Ben Chaska' and 'Ben Como'. These black currants have quality f...

  19. Hyper-resting brain entropy within chronic smokers and its moderation by Sex.

    PubMed

    Li, Zhengjun; Fang, Zhuo; Hager, Nathan; Rao, Hengyi; Wang, Ze

    2016-01-01

    Cigarette smoking is a chronic relapsing brain disorder, and remains a premier cause of morbidity and mortality. Functional neuroimaging has been used to assess differences in the mean strength of brain activity in smokers' brains, however less is known about the temporal dynamics within smokers' brains. Temporal dynamics is a key feature of a dynamic system such as the brain, and may carry information critical to understanding the brain mechanisms underlying cigarette smoking. We measured the temporal dynamics of brain activity using brain entropy (BEN) mapping and compared BEN between chronic non-deprived smokers and non-smoking controls. Because of the known sex differences in neural and behavioral smoking characteristics, comparisons were also made between males and females. Associations between BEN and smoking related clinical measures were assessed in smokers. Our data showed globally higher BEN in chronic smokers compared to controls. The escalated BEN was associated with more years of smoking in the right limbic area and frontal region. Female nonsmokers showed higher BEN than male nonsmokers in prefrontal cortex, insula, and precuneus, but the BEN sex difference in smokers was less pronounced. These findings suggest that BEN mapping may provide a useful tool for probing brain mechanisms related to smoking. PMID:27377552

  20. Changes in pathogenicity and immunogenicity of Mycoplasma mycoides subsp. mycoides strains revealed by comparative genomics analysis

    PubMed Central

    Li, Yuan; Wang, Yang; Wang, Rui; Zhu, Yongqiang; Liu, Suli; Wang, Qi; Shao, Jiari; Chen, Ying; Gao, Liping; Zhou, Changping; Liu, Henggui; Wang, Xiumei; Zheng, Huajun; Xin, Jiuqing

    2016-01-01

    Mycoplasma mycoides subsp. mycoides is the causative agent of contagious bovine pleuropneumonia. A pathogenic strain BEN-1 was isolated from bovine lung and underwent continuous passages in rabbits for 468 generations. During this process, the strain’s strong virulence became weak and, gradually, it lost the ability to confer protective immunity in cattle but developed virulence in rabbits. In order to gain insight into the mechanisms behind the reduction in virulence and the loss of immunogenicity, we sequenced five representative strains of the BEN series, including the original strain (BEN-1), the strain generation that first acquired virulence in rabbits (BEN-50), the two vaccine strain generations (BEN-181 and BEN-326), and the strain generation showing the greatest loss of immunogenicity (BEN-468). The gene mutation rate in the four different propagation stages varied greatly, and over half of variations observed in each generation were removed during the propagation process. However, the variation maintained in the BEN-468 generation might contribute to its changes in virulence and immunogenicity. We thus identified 18 genes associated with host adaptation, six genes contributing to virulence in cattle, and 35 genes participating in conferring immunity in cattle. These findings might help us optimize the vaccine to obtain more effective immunization results. PMID:26750304

  1. Changes in pathogenicity and immunogenicity of Mycoplasma mycoides subsp. mycoides strains revealed by comparative genomics analysis.

    PubMed

    Li, Yuan; Wang, Yang; Wang, Rui; Zhu, Yongqiang; Liu, Suli; Wang, Qi; Shao, Jiari; Chen, Ying; Gao, Liping; Zhou, Changping; Liu, Henggui; Wang, Xiumei; Zheng, Huajun; Xin, Jiuqing

    2016-01-01

    Mycoplasma mycoides subsp. mycoides is the causative agent of contagious bovine pleuropneumonia. A pathogenic strain BEN-1 was isolated from bovine lung and underwent continuous passages in rabbits for 468 generations. During this process, the strain's strong virulence became weak and, gradually, it lost the ability to confer protective immunity in cattle but developed virulence in rabbits. In order to gain insight into the mechanisms behind the reduction in virulence and the loss of immunogenicity, we sequenced five representative strains of the BEN series, including the original strain (BEN-1), the strain generation that first acquired virulence in rabbits (BEN-50), the two vaccine strain generations (BEN-181 and BEN-326), and the strain generation showing the greatest loss of immunogenicity (BEN-468). The gene mutation rate in the four different propagation stages varied greatly, and over half of variations observed in each generation were removed during the propagation process. However, the variation maintained in the BEN-468 generation might contribute to its changes in virulence and immunogenicity. We thus identified 18 genes associated with host adaptation, six genes contributing to virulence in cattle, and 35 genes participating in conferring immunity in cattle. These findings might help us optimize the vaccine to obtain more effective immunization results. PMID:26750304

  2. The role of lecithin cholesterol acyltransferase and organic substances from coal in the etiology of Balkan endemic nephropathy: A new hypothesis

    USGS Publications Warehouse

    Pavlovic, N.M.; Orem, W.H.; Tatu, C.A.; Lerch, H.E.; Bunnell, J.E.; Feder, G.L.; Kostic, E.N.; Ordodi, V.L.

    2008-01-01

    Balkan endemic nephropathy (BEN) occurs in Serbia, Bulgaria, Romania, Bosnia and Herzegovina, and Croatia. BEN has been characterized as a chronic, slowly progressive renal disease of unknown etiology. In this study, we examined the influence of soluble organic compounds in drinking water leached from Pliocene lignite from BEN-endemic areas on plasma lecithin-cholesterol acyltransferase (LCAT) activity. We found that changes for all samples were the most prominent for the dilution category containing 90% plasma and 10% of diluting media. Water samples from BEN villages from Serbia and Romania showed higher LCAT inhibiting activity (p = 0.02) and (p = 0.003), respectively, compared to deionised water and non-endemic water. A secondary LCAT deficiency could result from this inhibitory effect of the organic compounds found in endemic water supplies and provide an ethiopathogenic basis for the development of BEN in the susceptible population. ?? 2007 Elsevier Ltd. All rights reserved.

  3. A possible link between Balkan endemic nephropathy and the leaching of toxic organic compounds from Pliocene lignite by groundwater: Preliminary investigation

    USGS Publications Warehouse

    Orem, W.H.; Feder, G.L.; Finkelman, R.B.

    1999-01-01

    Balkan endemic nephropathy (BEN) is a fatal kidney disease that is known to occur only in clusters of villages in alluvial valleys of tributaries of the Danube River in Bulgaria, Romania, Yugoslavia, Bosnia, and Croatia. The confinement of this disease to a specific geographic area has led to speculation that an environmental factor may be involved in the etiology of BEN. Numerous environmental factors have been suggested as causative agents for producing BEN, including toxic metals in drinking water, metal deficiency in soils of BEN areas, and environmental mycotoxins to name a few. These hypotheses have either been disproved or have failed to conclusively demonstrate a connection to the etiology of BEN, or the clustering of BEN villages. In previous work, we observed a distinct geographic relationship between the distribution of Pliocene lignites in the Balkans and BEN villages. We hypothesized that the long-term consumption of well water containing toxic organic compounds derived from the leaching of nearby Pliocene lignites by groundwater was a primary factor in the etiology of BEN. In our current work, chemical analysis using 13C nuclear magnetic resonance (13CNMR) spectroscopy indicated a high degree of organic functionality in Pliocene lignite from the Balkans, and suggested that groundwater can readily leach organic matter from these coal beds. Semi-quantitative gas chromatography/mass spectroscopy analysis of solvent extracts of groundwater from shallow wells in BEN villages indicated the presence of potentially toxic aromatic compounds, such as napthalene, fluorene, phenanthrene, and pyrene at concentrations in the ppb range. Laboratory leaching of Balkan Pliocene lignites with distilled water yielded soluble organic matter (> 500 MW) containing large amounts of aromatic structures similar to the simple/discrete aromatic compounds detected in well water from BEN villages. These preliminary results are permissive of our hypothesis and suggest that further

  4. Correlation Of Balkan Endemic Nephropathy With Fluorescent Organic Compounds In Shallow Groundwater

    NASA Astrophysics Data System (ADS)

    Goldberg, Marvin C.; Feder, Gerald L.; Radovanovic, Zoran

    1994-04-01

    Balkan endemic nephropathy (BEN) is a disease of intersitial nephropathy leading to end-stage renal failure. The disease occurs in persons living in villages on alluvial valleys of streams tributary to the Danube River in Rumania, Bulgaria and former Yugoslavia. The etiologic agent is not known, but a contaminant in shallow groundwater has become suspect. In this study, samples of drinking water from endemic and non-endemic village water supplies were analyzed by excitation/emission matrix (EEM) fluorescence spectroscopy. Spectra characteristic of groundwater from BEN households show elongated teardrop shapes in the fluorescence excitation/emission matrix. A sharp rise occurs in fluorescence emission between 380 and 400 nanometers (nm) and a trailing emission intensity from 400 to 550 nm. Spectra of groundwater samples from some BEN households have an additional excitation maxima at 300 nm, which further contributes to the emission intensity at 400 nm. Spectra of water samples from non-BEN households located in endemic villages show characteristics of BEN household waters, exhibiting the 250-nm excitation peak, even though the fluorophoric intensity is much less than that in samples from BEN household waters. Samples from non-endemic villages do not show the characteristic EEM spectra described as "teardrop shaped". The non-BEN households have lower concentrations of these fluorophores in the drinking water than the endemic households; hence, one of the factors in contracting the disease may be the concentration of these fluorescent materials in drinking water.

  5. Endemic nephropathy and upper urothelial carcinoma--new insights in molecular biology.

    PubMed

    Jankovic Velickovic, Ljubinka; Dolicanin, Zana; Stefanovic, Vladisav

    2014-01-01

    Upper Tract Urothelial Carcinoma (UTUC) is an uncommon disease which occurs more frequently in some regions of Balkan countries than in other areas in the world. Investigation of UTUC in the South Morava River basin and its tributaries where BEN is endemic revealed increased frequency not only of tumour of the renal pelvis and ureter but also of urinary bladder tumours. A comparative morphological and immunohistochemical study of UTUC in the BEN region and control rural and city populations free of BEN, identify growth pattern as the best morphological characteristic which differentiated BEN and control tumours, i.e. solid growth for BEN tumours and papillary for control tumours. Overexpression of tumour suppressor p53 as well as decreased expression of E-CD was detected in BEN tumours. Other cells cycle related molecular markers--Cyclin D1, p16, and HER-2 showed no difference in expression between groups, as well as the proliferative marker Ki-67. Investigation of apoptosis-related markers identifies Bax as a specific marker of BEN-associated UTUC. Decrease of the pro-apoptotic protein Bax together with alteration of Survivin may be indicative of specific disturbances of an intrinsic apoptotic pathway in UTUC arising in endemic areas. PMID:24802310

  6. Balkan nephropathy: evolution of our knowledge.

    PubMed

    Bamias, Giorgos; Boletis, John

    2008-09-01

    Balkan endemic nephropathy (BEN), originally described in the late 1950s as a chronic tubulointerstitial kidney disease, is identified by its unique epidemiological features. The most remarkable characteristic of BEN is the focal topographical nature that characterizes its occurrence at the global, national, and even household level. BEN affects only certain endemic rural foci along tributaries of the Danube River in the Balkan countries of Bosnia, Bulgaria, Croatia, Romania, and Serbia. The spatial distribution has remained astonishingly unchanged with time because the disease affects the same endemic clusters as 50 years ago. The natural course of the disease is characterized by universal development of end-stage renal disease and the frequent development of upper urinary tract tumors, posing a substantial disease burden to the afflicted areas. The greatest challenge in the study of BEN has been the elucidation of its cause. The unique features of the disease, in particular its endemic nature and the long incubation period required for the disease to develop, have led to the proposal that BEN represents a unique environmental disease. The quest for the responsible environmental factor has been long and diverse, and although no definitive answer has been provided to date, converging lines of evidence support the theory that long-term consumption of food contaminated with aristolochic acid underlies the pathogenesis of BEN. The present review describes the evolution of our knowledge of BEN in relation to the development of the main theories for its pathogenesis. PMID:18725017

  7. Values of Alpha 1 Microglobulin Does Not Differ between Individuals with and without Family History of Balkan Endemic Nephropathy

    PubMed Central

    Trnacevic, Senaid; Hodzic, Emir; Atic, Mirza; Dugonjic, Maida; Hasanovic, Evlijana

    2014-01-01

    Aim. The aim of this study was to compare urinary alpha 1 microglobulin (A1MG) in healthy individuals with and without family burden for Balkan endemic nephropathy (BEN) in an endemic village. Methods. Otherwise healthy inhabitants with microalbuminuria or proteinuria were divided into two groups: with (n = 24) and without (n = 32) family BEN burden and screened for urinary A1MG and A1MG/urine creatinine ratio. Results. Average value of urinary A1MG was 10.35 ± 7.01 mg/L in group with and 10.79 ± 8.27 mg/L in group without family history for BEN (NS, P = 0.87). A1MG was higher than 10 mg/L in eight (33.33%) inhabitants with family history and in 12 (37.5%) without (NS, P = 0.187). Average values of urinary A1MG/creatinine ratio were 1.30 ± 1.59 and 0.94 ± 0.78 in group with and group without family BEN history (NS, P = 0.39, resp.). Elevated values of this ratio were found in 13 (54.17%) inhabitants with and 14 (43.75%) without family history for BEN (NS, P = 0.415). Conclusion. We did not find statistically significant difference in the examined markers between healthy individuals with and without family burden for BEN. We concluded that these markers are not predictive of risk for BEN. PMID:24563783

  8. Balkan endemic nephropathy—current status and future perspectives

    PubMed Central

    Pavlović, Nikola M.

    2013-01-01

    Balkan endemic nephropathy (BEN), originally described in 1956, is a unique familial, chronic renal disease encountered with a high-prevalence rate in Serbia, Bulgaria, Romania, Croatia and Bosnia and Herzegovina. The most prominent features of the disease are its endemic nature, long-incubation period, familial clustering of the disease and an unusually high incidence of associated upper urothelial cancer (UUC). There are no clear-cut data on BEN incidence and prevalence, since the studies carried out in different endemic areas yielded contradictory information. In spite of intermittent variations, the incidence of new cases has remained stable over time. It has been estimated that almost 100 000 people are at risk of BEN, whereas 25 000 have the disease. The clinical signs and symptoms of BEN are non-specific and often remain unrecognized for years. There are no pathognomonic diagnostic features of BEN, but the set of epidemiological, clinical and biochemical data along with the pattern of pathologic injury in the absence of any other renal diseases are highly suggestive of this entity. Although the aetiology has been extensively studied, fostering the publication of various hypotheses, only one of them has provided conclusive evidence related to the aetiology of BEN. Studies conducted over the past decade have provided particularly strong arguments that BEN and UUC are caused by chronic poisoning with aristolochic acids (AAs). In light of these later studies, one can raise the question whether AAs could be responsible for previously and currently widespread unrecognized global renal disease and UUC. PMID:26064484

  9. Cloning and Characterization of Benzoate Catabolic Genes in the Gram-Positive Polychlorinated Biphenyl Degrader Rhodococcus sp. Strain RHA1

    PubMed Central

    Kitagawa, Wataru; Miyauchi, Keisuke; Masai, Eiji; Fukuda, Masao

    2001-01-01

    Benzoate catabolism is thought to play a key role in aerobic bacterial degradation of biphenyl and polychlorinated biphenyls (PCBs). Benzoate catabolic genes were cloned from a PCB degrader, Rhodococcus sp. strain RHA1, by using PCR amplification and temporal temperature gradient electrophoresis separation. A nucleotide sequence determination revealed that the deduced amino acid sequences encoded by the RHA1 benzoate catabolic genes, benABCDK, exhibit 33 to 65% identity with those of Acinetobacter sp. strain ADP1. The gene organization of the RHA1 benABCDK genes differs from that of ADP1. The RHA1 benABCDK region was localized on the chromosome, in contrast to the biphenyl catabolic genes, which are located on linear plasmids. Escherichia coli cells containing RHA1 benABCD transformed benzoate to catechol via 2-hydro-1,2-dihydroxybenzoate. They transformed neither 2- nor 4-chlorobenzoates but did transform 3-chlorobenzoate. The RHA1 benA gene was inactivated by insertion of a thiostrepton resistance gene. The resultant mutant strain, RBD169, neither grew on benzoate nor transformed benzoate, and it did not transform 3-chlorobenzoate. It did, however, exhibit diminished growth on biphenyl and growth repression in the presence of a high concentration of biphenyl (13 mM). These results indicate that the cloned benABCD genes could play an essential role not only in benzoate catabolism but also in biphenyl catabolism in RHA1. Six rhodococcal benzoate degraders were found to have homologs of RHA1 benABC. In contrast, two rhodococcal strains that cannot transform benzoate were found not to have RHA1 benABC homologs, suggesting that many Rhodococcus strains contain benzoate catabolic genes similar to RHA1 benABC. PMID:11673430

  10. Signature Peptide-Enabled Metagenomics (Seventh Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting 2012)

    ScienceCinema

    McMahon, Ben [LANL

    2013-01-25

    Ben McMahon of Los Alamos National Laboratory (LANL) presents "Signature Peptide-Enabled Metagenomics" at the 7th Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting held in June, 2012 in Santa Fe, NM.

  11. Dual delivery systems based on polyamine analog BENSpm as prodrug and gene delivery vectors

    NASA Astrophysics Data System (ADS)

    Zhu, Yu

    Combination drug and gene therapy shows promise in cancer treatment. However, the success of such strategy requires careful selection of the therapeutic agents, as well as development of efficient delivery vectors. BENSpm (N 1, N11-bisethylnorspermine), a polyamine analogue targeting the intracellular polyamine pathway, draws our special attention because of the following reasons: (1) polyamine pathway is frequently dysregulated in cancer; (2) BENSpm exhibits multiple functions to interfere with the polyamine pathway, such as to up-regulate polyamine metabolism enzymes and down-regulate polyamine biosynthesis enzymes. Therefore BENSpm depletes all natural polyamines and leads to apoptosis and cell growth inhibition in a wide range of cancers; (3) preclinical studies proved that BENSpm can act synergistically with various chemotherapy agents, making it a promising candidate in combination therapy; (4) multiple positive charges in BENSpm enable it as a suitable building block for cationic polymers, which can be further applied to gene delivery. In this dissertation, our goal was to design dual-function delivery vector based on BENSpm that can function as a gene delivery vector and, after intracellular degradation, as an active anticancer agent targeting dysregulated polyamine metabolism. We first demonstrated strong synergism between BENSpm and a potential therapeutic gene product TRAIL. Strong synergism was obtained in both estrogen-dependent MCF-7 breast cancer cells and triple-negative MDA-MB-231 breast cancer cells. Significant dose reduction of TRAIL in combination with BENSpm in MDA-MB-231 cells, together with the fact that BENSpm rendered MCF-7 cells more sensitive to TRAIL treatment verified our rationale of designing BENSpm-based delivery platform. This was expected to be beneficial for overcoming drug resistance in chemotherapy, as well as boosting the therapeutic effect of therapeutic genes. We first designed a lipid-based BENSpm dual vector (Lipo-SS-BEN

  12. Meanwhile, at the Bottom of the Ocean ...

    NASA Video Gallery

    The Ben Franklin mission has been forgotten by time, overshadowed by the concurrent Apollo 11 mission. However, the scientific findings obtained by six aquanauts have provided a foundation for unde...

  13. Hey! A Fire Ant Stung Me!

    MedlinePlus

    ... play with it. Reviewed by: Elana Pearl Ben-Joseph, MD Date reviewed: April 2016 For Teens For Kids For Parents MORE ON THIS TOPIC Camping and Woods Safety Hey! A Black Widow Spider Bit Me! Learning About Allergies Hey! ...

  14. Correction: Single-molecule magnet behaviour in polynuclear assembly of trivalent cerium ions with polyoxomolybdates.

    PubMed

    Khélifa, A Ben; Belkhiria, M Salah; Huang, G; Freslon, S; Guillou, O; Bernot, K

    2016-06-01

    Correction for 'Single-molecule magnet behaviour in polynuclear assembly of trivalent cerium ions with polyoxomolybdates' by A. Ben Khélifa, et al., Dalton Trans., 2015, 44, 16458-16464. PMID:27161299

  15. Signature Peptide-Enabled Metagenomics (Seventh Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting 2012)

    SciTech Connect

    McMahon, Ben

    2012-06-01

    Ben McMahon of Los Alamos National Laboratory (LANL) presents "Signature Peptide-Enabled Metagenomics" at the 7th Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting held in June, 2012 in Santa Fe, NM.

  16. Genetics Home Reference: fucosidosis

    MedlinePlus

    ... muscle stiffness (spasticity); clusters of enlarged blood vessels forming small, dark red spots on the skin (angiokeratomas); ... link) FUCOSIDOSIS Sources for This Page Ben Turkia H, Tebib N, Azzouz H, Abdelmoula MS, Bouguila J, ...

  17. Dengue Fever

    MedlinePlus

    ... away from areas that have a dengue fever epidemic, the risk of contracting dengue fever is small for international travelers./p> Reviewed by: Elana Pearl Ben-Joseph, ... Nile Virus First Aid: Vomiting Are Insect Repellents With DEET ...

  18. SOLUTION RHEOLOGY OF HYPERBRANCHED POLYESTERS AND THEIR BLENDS WITH LINEAR POLYMERS

    EPA Science Inventory

    In this study, the rheological properties of different generations of hyperbranched polyesters in 1-methyl-2-pyrrolidinone solvent and their blends with poly(2-hydroxyethyl methacrylate) have ben investigated. All the hyperbranched polyester solutions exhibited Newtonian behavior...

  19. 75 FR 31770 - Notice of Intent To Prepare an Environmental Impact Statement (EIS) for Training Land Expansion...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-04

    ... they train at home station to deploy to support operations abroad. This action will also support the... distinct study areas southeast and south of Fort Benning in Chattahoochee, Marion, Webster, and...

  20. 17. Woodworking Mill (basement): view looking north showing Ames Iron ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. Woodworking Mill (basement): view looking north showing Ames Iron Works steam boiler; note turbine control handle in middle right of photo - Ben Thresher's Mill, State Aid No. 1, Barnet, Caledonia County, VT

  1. ISS Update: Robotic Refueling Mission Payload Overview

    NASA Video Gallery

    Public Affairs Officer Kyle Herring talks by phone with Ben Reed, Deputy Project Manager of the Satellite Servicing Capabilities Office at Goddard Space Flight Center. They talk about the Robotic R...

  2. 18. Blacksmith Shop (first floor): view looking north; trip hammer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. Blacksmith Shop (first floor): view looking north; trip hammer and coal bin in background, shears and swage block in foreground - Ben Thresher's Mill, State Aid No. 1, Barnet, Caledonia County, VT

  3. Probing the Milky Way

    NASA Astrophysics Data System (ADS)

    Asanok, Kitiyanee; Fenech, Danielle; Greaves, Jane; Healy, Fiona; Hoare, Melvin; Mooley, Kunal; Prinja, Raman; Rodriguez, Luiz; Shaw, Ben; Walker, Charlie

    2016-06-01

    Charlie Walker, Ben Shaw and colleagues give an overview of how the sensitivity, superb resolution and lack of obscuration in e-MERLIN data is changing what we know about our home galaxy and the lifecycles of its stars.

  4. Methyl salicylate overdose

    MedlinePlus

    Deep heating rubs overdose; Oil of wintergreen overdose ... These products contain methyl salicylate: Deep-heating creams used to relieve sore muscles and joints (Ben Gay, Icy Hot) Oil of wintergreen Solutions for vaporizers Other products ...

  5. Determination of β haplotypes in patients with sickle-cell anemia in the state of Rio Grande do Norte, Brazil.

    PubMed

    Cabral, Cynthia Hatsue Kitayama; Serafim, Edvis Santos Soares; de Medeiros, Waleska Rayane Dantas Bezerra; de Medeiros Fernandes, Thales Allyrio Araújo; Kimura, Elza Miyuki; Costa, Fernando Ferreira; de Fátima Sonati, Maria; Rebecchi, Ivanise Marina Moretti; de Medeiros, Tereza Maria Dantas

    2011-07-01

    β(S) haplotypes were studied in 47 non-related patients with sickle-cell anemia from the state of Rio Grande do Norte, Brazil. Molecular analysis was conducted by PCR/RFLP using restriction endonucleases XmnI, HindIII, HincII and HinfI to analyze six polymorphic sites from the beta cluster. Twenty-seven patients (57.5%) were identified with genotype CAR/CAR, 9 (19.1%) CAR/BEN, 6 (12.8%) CAR/CAM, 1 (2.1%) BEN/BEN, 2 (4.3%) CAR/Atp, 1 (2.1%) BEN/Atp and 1 (2.1%) with genotype Atp/Atp. The greater frequency of Cameroon haplotypes compared to other Brazilian states suggests the existence of a peculiarity of African origin in the state of Rio Grande do Norte. PMID:21931513

  6. Space Station Live: Students Help Build Station Trainers

    NASA Video Gallery

    NASA Public Affairs Officer Josh Byerly speaks with students Ben Holloway, Helmut Brenner and Robert Lipham from Cypress Woods High School in Cypress, Texas, about their experiences in the HUNCH ed...

  7. 12. Wagon Repair and Paint Shop (second floor in Woodworking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Wagon Repair and Paint Shop (second floor in Woodworking Mill): view looking east showing paint storage on left and old living quarters on right - Ben Thresher's Mill, State Aid No. 1, Barnet, Caledonia County, VT

  8. Determination of βS haplotypes in patients with sickle-cell anemia in the state of Rio Grande do Norte, Brazil

    PubMed Central

    Cabral, Cynthia Hatsue Kitayama; Serafim, Édvis Santos Soares; de Medeiros, Waleska Rayane Dantas Bezerra; de Medeiros Fernandes, Thales Allyrio Araújo; Kimura, Elza Miyuki; Costa, Fernando Ferreira; de Fátima Sonati, Maria; Rebecchi, Ivanise Marina Moretti; de Medeiros, Tereza Maria Dantas

    2011-01-01

    βS haplotypes were studied in 47 non-related patients with sickle-cell anemia from the state of Rio Grande do Norte, Brazil. Molecular analysis was conducted by PCR/RFLP using restriction endonucleases XmnI, HindIII, HincII and HinfI to analyze six polymorphic sites from the beta cluster. Twenty-seven patients (57.5%) were identified with genotype CAR/CAR, 9 (19.1%) CAR/BEN, 6 (12.8%) CAR/CAM, 1 (2.1%) BEN/BEN, 2 (4.3%) CAR/Atp, 1 (2.1%) BEN/Atp and 1 (2.1%) with genotype Atp/Atp. The greater frequency of Cameroon haplotypes compared to other Brazilian states suggests the existence of a peculiarity of African origin in the state of Rio Grande do Norte. PMID:21931513

  9. 75 FR 39497 - Procurement List; Proposed Additions and Deletion

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-09

    ..., Fort Benning, GA. NPA: Job Options, Inc., San Diego, CA. Contracting Activity: Dept of the Army, XU W40M Southeast Regional Contracting Office, Fort Gordon, GA. Service Type/Location: Operations...

  10. A vet with a vision.

    PubMed

    Ben-Shlomo, Gil

    2016-09-10

    When he learned what being a veterinarian meant, Gil Ben-Shlomo felt that the career had been invented especially for him. He has since specialised, and is now professor of ophthalmology at Iowa State University. PMID:27609975

  11. Caring after conflict.

    PubMed

    Dallaire, Roméo

    2012-07-01

    Senator Roméo Dallaire commanded the UN Assistance Mission for Rwanda in 1994. He spoke to Ben Jones about helping combatants after conflict, child soldiers and why writing his books meant "going back to hell". PMID:22807593

  12. Developing Creativity Ecosystems: Preparing College Students for Tomorrow's Innovation Challenge

    ERIC Educational Resources Information Center

    Hulme, Eileen; Thomas, Ben; DeLaRosby, Hal

    2014-01-01

    Eileen Hulme, Ben Thomas, and Hal DeLaRosby argue for the importance of creativity as a learning outcome and challenge higher education to produce students capable of becoming the innovative leaders the twenty-first-century economy requires.

  13. How and Why I Built a Research Laboratory

    NASA Astrophysics Data System (ADS)

    Lakhdar, Zohra Ben

    2005-10-01

    The 2005 L'ORÉAL-UNESCO award for women in physics recognized Zohra Ben Lakhdar's contributions to research in Tunisia. But when Professor Ben Lakhdar was a young girl in 1950s Tunisia, girls did not go to school beyond the elementary grades, and she found herself under the tutelage of her mother learning how to take care of a family and home. Tunisia's independence in 1956 changed that, and Professor Ben Lakhdar soon became the only girl in an all-boys' college. In 1978 when she returned to Tunisia after earning her PhD in Paris, fewer than 10 Tunisians were doing research. But the number of students in the country was increasing and trained teachers were needed. Developing the capability to do research in Tunisia was urgent. So Professor Ben Lakhdar built a research laboratory in Tunisia. This paper tells the story.

  14. High School Parking Lots.

    ERIC Educational Resources Information Center

    Neff, Thomas G.

    2002-01-01

    Describes the reorganization of the site of Ben Davis High School in Wayne Township, Indiana as an example of improvements to school parking lot design and vehicle/pedestrian traffic flow and security. Includes design drawings. (EV)

  15. VIEW IN OPPOSITE DIRECTION AS MD1351 AND MD1352. RAW MATERIAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW IN OPPOSITE DIRECTION AS MD-135-1 AND MD-135-2. RAW MATERIAL CONVEYOR AT LEFT DEPOSITS SHELL INTO MILLING MACHINE AT LOWER LEFT. ENGINE IS AT LOWER RIGHT AND RADIATOR AT LOWER CENTER. ROLLER SORTER IS AT TOP OF CONVEYOR. - F. & H. Benning Company Oyster Mill, 14430 Solomons Island Road (moved from 1014 Benning Road, Galesville, Anne Arundel County, Maryland), Solomons, Calvert County, MD

  16. P19 contributes to Mycoplasma mycoides subsp. mycoides adhesion to EBL cells.

    PubMed

    Zhou, Yumei; Wang, Yang; Li, Yuan; Nick, Nwankpa; Zou, Xiaohui; Bai, Fan; Wu, Jindi; Xin, Jiuqing

    2016-04-01

    Mycoplasma mycoides subsp. mycoides (Mmm) is the causative agent of contagious bovine pleuropneumonia (CBPP). The virulent Mmm Ben-1 strain was isolated from the lung of a CBPP-infected cow in China in the 1950s. To attenuate the virulence of the Ben-1 strain and preserve its protective ability, the isolate was re-isolated after inoculation into the testicles of rabbits and into the rabbit thorax. As a result, after the subsequent isolates were continuously passaged 468 times in rabbits, its pathogenicity to cattle decreased. However, the molecular mechanisms leading to attenuation of the Mmm Ben-1 remain unknown. We compared the entire genomes of the Ben-1 strain and the 468 th generation strain passaged in rabbits (Ben-468) and discovered that a putative protein gene named p19 was absent from the Ben-468 strain. The p19 gene was cloned and expressed in Escherichia coli to obtain recombinant P19 (rP19). Western blot analysis demonstrated that the P19 protein is detected in the cell-membrane fraction, the cell-soluble cytosolic fraction and whole-cell lysate of the Mmm Ben-1 strain. The rP19 can interact with international standard serum against CBPP. Immunostaining visualised via confocal laser scanning microscopy indicated that P19 is able to adhere to embryonic bovine lung (EBL) cells, and this finding was also confirmed by a sandwich ELISA. We also found that anti-rP19 serum could inhibit the adhesion of the Mmm Ben-1 total proteins to EBL cells. PMID:26806796

  17. Betaine protects cerebellum from oxidative stress following levodopa and benserazide administration in rats

    PubMed Central

    Alirezaei, Masoud

    2015-01-01

    Objective(s): The aim of the present study was to evaluate antioxidant and methyl donor effects of betaine in cerebellum following levodopa and benserazide administration in rats. Materials and Methods: Sprague-Dawley male rats were treated with levodopa (LD), betaine (Bet), levodopa plus betaine (LD/Bet), levodopa plus benserazide (LD/Ben), levodopa plus betaine-benserazide (LD/Bet-Ben), and the controls with vehicle for 10 consecutive days, orally. Results: Treatment of rats with LD and benserazide significantly increased total homocysteine in plasma of the LD/Ben group when compared to the other groups. Lipid peroxidation of cerebellum increased significantly in LD-treated rats when compared to the other groups. In contrast, glutathione peroxidase activity and glutathione content in cerebellum were significantly higher in the betaine-treated rats when compared to the LD and LD/Ben groups. Serum dopamine concentration increased significantly in LD-treated rats in comparison with the LD/Ben group. LD/Bet-treated rats also demonstrated significantly higher dopamine levels when compared to the LD/Ben group. Conclusion: We observed valuable effects of Bet in combination with LD and benserazide, which routinely were used for Parkinson’s disease (PD) treatment, in experimentally-induced oxidative stress and hyperhomocysteinemia in rats. Therefore, it seems that Bet is a vital and promising agent regarding PD for future clinical trials in humans. PMID:26730328

  18. Evaluating Weight of Evidence in the Mystery of Balkan Endemic Nephropathy

    PubMed Central

    Bui-Klimke, Travis; Wu, Felicia

    2014-01-01

    Balkan Endemic Nephropathy (BEN) is a chronic, progressive wasting disease of the kidneys, endemic in certain rural regions of the Balkan nations Croatia, Serbia, Bulgaria, and Romania. It is irreversible, and ultimately fatal. Though this disease was first described in the 1920s, its causes have been a mystery and a source of much academic and clinical contention. Possible etiologic agents that have been explored include exposure to metals and metalloids, viruses and bacteria, and the environmental toxins aristolochic acid (AA) and ochratoxin A (OTA). Aristolochic acid is a toxin produced by weeds of the genus Aristolochia, common in Balkan wheat fields. Aristolochia seeds may intermingle with harvested grains and thus inadvertently enter human diets. Ochratoxin A is a mycotoxin (fungal toxin) common in many foods, including cereal grains. In this study, we analyzed the weight of evidence for each of the suspected causes of BEN using the Bradford Hill Criteria (BHC): nine conditions that determine weight of evidence for a causal relationship between an agent and a disease. Each agent postulated to cause BEN was evaluated using the nine criteria, and for each criterion was given a rating based on the strength of the association between exposure to the substance and BEN. From the overall available scientific evidence for each of these suspected risk factors, aristolochic acid is the agent with the greatest weight of evidence in causing BEN. We describe other methods for testing causality from epidemiological studies, which support this conclusion of AA causing BEN. PMID:24954501

  19. Angiogenesis in upper tract urothelial carcinoma associated with Balkan endemic nephropathy

    PubMed Central

    Velickovic, Ljubinka Jankovic; Petrovic, Ana Ristic; Stojnev, Slavica; Dolicanin, Zana; Hattori, Takanori; Sugihara, Hiroyuki; Mukaisho, Ken-ichi; Stojanovic, Mariola; Stefanovic, Vladisav

    2012-01-01

    Upper tract urothelial carcinoma (UTUC) associated with Balkan endemic nephropathy (BEN) is characterized by a number of aberrations in cell-cycle regulation and apoptosis. The aim of this study was to detect angiogenesis-related marker(s) specific for BEN UTUC, and to examine the influence of HIF 1α upon angiogenesis and apoptosis in UTUC. Present investigation included 110 patients with UTUC, 50 from BEN region and 60 control tumors. Altered expression of VEGFR1 was more often present in control UTUC than in BEN tumors (p<0.005). It was associated with high grade, low and high stage, solid growth, and metaplastic change of control UTUC. Microvessel density assessed by CD31 (MVD CD31) was significantly higher in UTUC with lymphovascular invasion (p<0.05), and in BEN tumors with papillary growth (p<0.05). Discriminant analysis indicated that BEN and control tumors do not differ significantly in expression of angiogenesis related markers. The most important discriminant variable that determined control UTUC was expression of VEGFR1 (p=0.002). HIF 1α in UTUC significantly correlated with the low stage, papillary growth and expression of Bcl-2, Caspase-3 index, and MVD CD34 (p<0.001; 0.0005; 0.01; 0.005; 0.01, respectively). HIF-1α may be helpful marker in evaluation of UTUC, especially when combined with angiogenesis and apoptosis. PMID:22977664

  20. Locus control region HS2 point mutations are generally not responsible for elevated fetal hemoglobin expression of sickle cell patients

    SciTech Connect

    Gilman, J.G.

    1994-09-01

    The locus control region (LCR), composed of four hypersensitive sites (HS1-4) 5{prime} of the {epsilon} globin gene, confers strong, copy-number dependent expression on globin genes in transgenic mice. Several {beta}-globin gene cluster haplotypes carry the sickle cell gene, and show variable levels of fetal hemoglobin (Hb F) expression in association with DNA sequence differences in HS2, {gamma} and {beta} globin promoters, and {gamma}IVSII: The Senegal (SEN or No. 3) haplotype generally has high (>10%) Hb F, Benin (BEN or No. 19) has intermediate Hb F (but some low and some high), and Banu (BAN or No. 20) generally has low Hb F. Huisman and colleagues have proposed that `factors produced under conditions of hematopoietic stress, together with genetic determinants on the haplotype-3 like LCR sequences, allow for high level expression of {gamma} globin genes`. We have now used slot blot to screen high Hb F (>9.5%) and low Hb F cases for two of the three HS2 point mutations described by Oener et al. Comparing eight high Hb F BEN/BEN with two low Hb F BEN/BEN, all ten had the BEN mutations considered by Oener et al. to be associated with low Hb F. Comparing three high Hb F BEN/BAN with two low Hb F BEN/BAN, all five were heterozygous at three positions; this is consistent with BEN having G and T and BAN having A at both positions. DNA sequencing of HS2 for BAN, which is generally associated with low HB F, showed that the point mutations at all three positions were those seen in SEN (generally high Hb F); only the AT repeat region showed major differences, confirming results of Huisman and colleagues. Hence, if there is any effect of HS2 of the Senegal sickle cell haplotype in causing elevated Hb F under hematopoietic stress, it must be due to specific variation in the AT repeat region, which Oener et al. have suggested may bind a silencer.

  1. Constant sediment budget of Mekong delta shorelines: implications from long-term shoreline changes

    NASA Astrophysics Data System (ADS)

    Tamura, T.; Saito, Y.; Nguyen, V. L.; Ta, T. K. O.

    2015-12-01

    The sustainability of delta shorelines requires the sufficient sediment supply that is equal to or more than the sediment removal by tides and waves. The Mekong River delta, southern Vietnam, is a mixed-energy, complicated system with multiple delta plain shorelines that share the sediment supply from the river. We reconstructed the long-term shoreline changes of the Mekong delta over the last 2500 years based on the architecture and chronology of beach ridges on three delta plain in Ben Tre (North, Central, and South Ben Tre), and a delta plain in Tra Vinh to consider the sediment flux and its contribution to the growth of individual delta plains. While each delta plain shows temporal changes in growth rate, the sum of these four plains is nearly constant. This implies that the net sediment supply to the shorelines is constant, and that the geomorphological changes at distributary branches cause changes in sediment supply to each shoreline compartment. The distributary between North and Central Ben Tre was choked sometime between 500 and 1000 years ago, causing the rapid and stagnant shoreline progradation in North and Central Ben Tre, respectively. The shoreline of Central Ben Tre however has prograded slowly even after the choking, suggesting the beach sand can be supplied beyond the distributary or onshore from the delta front. Pre-industrial changes in delta geomorphology, based on geological records, improve the understanding of the delta systems and when compared with historical changes, diagnose the post-industrial state of delta.

  2. (abstract) Line Mixing Behavior of Hydrogen-Broadened Ammonia Under Jovian Atmospheric Conditions

    NASA Technical Reports Server (NTRS)

    Spilker, Thomas R.

    1994-01-01

    Laboratory spectral data reported last year have been used to investigate the line mixing behavior of hydrogen-broadened ammonia inversion lines. The data show that broadening parameters appearing in the modified Ben-Reuven opacity formalism of Berge and Gulkis (1976) cannot maintain constant values over pressure ranges that include low to moderate pressures and high pressures. Also, they cannot change drastically in value, as in the Spilker (1990) revision of the Berge and Gulkis formalism. It has long been recognized that at low pressures, less than about 1 bar of a Jovian atmospheric mixture, a VVW formalism yields more accurate predictions of ammonia opacity than Ben-Reuven formalisms. At higher pressures the Ben-Reuven formalisms are more accurate. Since the Ben-Reuven lineshape collapses to a VVW lineshape in the low pressure limit, this low pressure inaccuracy of the Ben-Reuven formalisms is surprising. By incorporating various behavior, a new formalism is produced that is more accurate than previous formalisms, particularly in the critical 'transition region' from 0.5 to 2 bars, and that can be used without discontinuity from pressures of zero to hundreds of bars. The new formalism will be useful in such applications as interpretation of radio astronomical and radio occultation data on giant planet atmospheres, and radiative transfer modeling of those atmospheres.

  3. HLB1 Is a Tetratricopeptide Repeat Domain-Containing Protein That Operates at the Intersection of the Exocytic and Endocytic Pathways at the TGN/EE in Arabidopsis[OPEN

    PubMed Central

    Sparks, J. Alan; Renna, Luciana; Liao, Fuqi; Brandizzi, Federica

    2016-01-01

    The endomembrane system plays essential roles in plant development, but the proteome responsible for its function and organization remains largely uncharacterized in plants. Here, we identified and characterized the HYPERSENSITIVE TO LATRUNCULIN B1 (HLB1) protein isolated through a forward-genetic screen in Arabidopsis thaliana for mutants with heightened sensitivity to actin-disrupting drugs. HLB1 is a plant-specific tetratricopeptide repeat domain-containing protein of unknown function encoded by a single Arabidopsis gene. HLB1 associated with the trans-Golgi network (TGN)/early endosome (EE) and tracked along filamentous actin, indicating that it could link post-Golgi traffic with the actin cytoskeleton in plants. HLB1 was found to interact with the ADP-ribosylation-factor guanine nucleotide exchange factor, MIN7/BEN1 (HOPM INTERACTOR7/BREFELDIN A-VISUALIZED ENDOCYTIC TRAFFICKING DEFECTIVE1) by coimmunoprecipitation. The min7/ben1 mutant phenocopied the mild root developmental defects and latrunculin B hypersensitivity of hlb1, and analyses of a hlb1/ min7/ben1 double mutant showed that hlb1 and min7/ben1 operate in common genetic pathways. Based on these data, we propose that HLB1 together with MIN7/BEN1 form a complex with actin to modulate the function of the TGN/EE at the intersection of the exocytic and endocytic pathways in plants. PMID:26941089

  4. Limitations and plausibility of the Pliocene lignite hypothesis in explaining the etiology of Balkan endemic nephropathy

    PubMed Central

    Maharaj, S V M

    2014-01-01

    Background: Balkan endemic nephropathy (BEN) is a chronic, tubulointerstitial renal disease often accompanied by urothelial cancer that has a lethality of nearly 100%. Introduction: One of the many factors that have been proposed to play an etiological role in BEN is exposure to organic compounds from Pliocene lignite coal deposits via the drinking water in endemic areas. Objectives: The objective of this study was to systematically evaluate the role of the tenets of the Pliocene lignite hypothesis in the etiology of BEN in order to provide an improved understanding of the hypothesis for colleagues and patients alike. Methods: A comprehensive compilation of the possible limitations of the hypothesis, with each limitation addressed in turn is presented. Results: The Pliocene lignite hypothesis can best account for, is consistent with, or has the potential to explain the evidence associated with the myriad of factors related to BEN. Conclusions: Residents of endemic areas are exposed to complex mixtures containing hundreds of organic compounds at varying doses and their potentially more toxic (including nephrotoxic) and/or carcinogenic metabolites; however, a multifactorial etiology of BEN appears most likely. PMID:24075451

  5. HLB1 Is a Tetratricopeptide Repeat Domain-Containing Protein That Operates at the Intersection of the Exocytic and Endocytic Pathways at the TGN/EE in Arabidopsis.

    PubMed

    Sparks, J Alan; Kwon, Taegun; Renna, Luciana; Liao, Fuqi; Brandizzi, Federica; Blancaflor, Elison B

    2016-03-01

    The endomembrane system plays essential roles in plant development, but the proteome responsible for its function and organization remains largely uncharacterized in plants. Here, we identified and characterized the HYPERSENSITIVE TO LATRUNCULIN B1 (HLB1) protein isolated through a forward-genetic screen in Arabidopsis thaliana for mutants with heightened sensitivity to actin-disrupting drugs. HLB1 is a plant-specific tetratricopeptide repeat domain-containing protein of unknown function encoded by a single Arabidopsis gene. HLB1 associated with the trans-Golgi network (TGN)/early endosome (EE) and tracked along filamentous actin, indicating that it could link post-Golgi traffic with the actin cytoskeleton in plants. HLB1 was found to interact with the ADP-ribosylation-factor guanine nucleotide exchange factor, MIN7/BEN1 (HOPM INTERACTOR7/BREFELDIN A-VISUALIZED ENDOCYTIC TRAFFICKING DEFECTIVE1) by coimmunoprecipitation. The min7/ben1 mutant phenocopied the mild root developmental defects and latrunculin B hypersensitivity of hlb1, and analyses of ahlb1/ min7/ben1 double mutant showed that hlb1 and min7/ben1 operate in common genetic pathways. Based on these data, we propose that HLB1 together with MIN7/BEN1 form a complex with actin to modulate the function of the TGN/EE at the intersection of the exocytic and endocytic pathways in plants. PMID:26941089

  6. Molecular and biological characterization of highly infectious transcripts from full-length cDNA clones of broad bean wilt virus 1.

    PubMed

    Ferriol, Inmaculada; Ambrós, Silvia; da Silva, Dorivaldo M; Falk, Bryce W; Rubio, Luis

    2016-06-01

    Broad bean wilt virus 1 (BBWV-1), genus Fabavirus, has a genome composed of two single-stranded positive-sense RNAs of ∼5.8 (RNA1) and 3.4kb (RNA2). Full-length cDNA clones of both genomic RNAs (pBenR1 and pBenR2) from BBWV-1 isolate Ben were constructed under the control of the T7 promoter. In vitro derived capped transcripts were infectious in Nicotiana benthamiana, Chenopodium quinoa and Vicia faba plants. The biological activity of viral transcripts was not affected by extra bases at the 5'-terminus introduced during in vitro transcription. Virions derived from the infectious cDNA clones displayed similar viral infectivity and accumulation, as well as symptom induction as the wild-type BBWV-1 isolate. PMID:26951858

  7. The etiology of Balkan endemic nephropathy: still more questions than answers.

    PubMed Central

    Tatu, C A; Orem, W H; Finkelman, R B; Feder, G L

    1998-01-01

    Balkan endemic nephropathy (BEN) has attracted increasing attention as a possible environmental disease, and a significant amount of research from complementary scientific fields has been dedicated to its etiology. There are two actual competing theories attempting to explain the cause of this kidney disease: 1) the mycotoxin hypothesis, which considers that BEN is produced by ochratoxin A ingested intermittently in small amounts by the individuals in the endemic regions, and 2) the Pliocene lignite hypothesis, which proposes that the disease is caused by long-term exposure to polycyclic aromatic hydrocarbons and other toxic organic compounds leaching into the well drinking water from low rank coals underlying or proximal to the endemic settlements. We outline the current developments and future prospects in the study of BEN and differentiate possible factors and cofactors in disease etiology. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 PMID:9799184

  8. The etiology of Balkan endemic nephropathy: Still more questions than answers

    USGS Publications Warehouse

    Tatu, C.A.; Orem, W.H.; Finkelman, R.B.; Feder, G.L.

    1998-01-01

    Balkan endemic nephropathy (BEN) has attracted increasing attention as a possible environmental disease, and a significant amount of research from complementary scientific fields has been dedicated to its etiology. There are two actual competing theories attempting to explain the cause of this kidney disease: 1) the mycotoxin hypothesis, which considers that BEN is produced by ochratoxin A ingested intermittently in small amounts by the individuals in the endemic regions, and 2) the Pliocene lignite hypothesis, which proposes that the disease is caused by long-term exposure to polycyclic aromatic hydrocarbons and other toxic organic compounds leaching into the well drinking water from low rank coals underlying or proximal to the endemic settlements. We outline the current developments and future prospects in the study of BEN and differentiate possible factors and cofactors in disease etiology.

  9. Natural Compounds as Potential Treatments of NF2-Deficient Schwannoma and Meningioma: Cucurbitacin D and Goyazensolide

    PubMed Central

    Spear, Samuel A.; Burns, Sarah S.; Oblinger, Janet L.; Ren, Yulin; Pan, Li; Kinghorn, A. Douglas; Welling, D. Bradley; Chang, Long-Sheng

    2015-01-01

    Hypothesis Cucurbitacin D and goyazensolide, two plant-derived natural compounds, possess potent growth-inhibitory activity in schwannoma and meningioma cells. Background Currently, no FDA-approved drugs are available for neurofibromatosis type 2 (NF2)-associated schwannomas and meningiomas. Selected natural compounds with antineoplastic activity, such as cucurbitacin and goyazensolide, may be developed as potential treatments for these tumors. Methods The Nf2-deficient mouse schwannoma Sch10545 and human benign meningioma Ben-Men-1 cells were treated with various concentrations of cucurbitacin D and goyazensolide. The effect on cell proliferation was determined using resazurin assays. Flow cytometry was used to assess the cell cycle profiles. Western blot analysis was performed to investigate the expression of various signal molecules related to the cell cycle and the AKT pathway. Results Cucurbitacin D inhibited proliferation of Sch10545 cells (IC50 ~0.75 μM) and Ben-Men-1 cells (IC50 ~0.2 μM). Goyazensolide also reduced cell proliferation of Sch10545 cells (IC50 ~0.9 μM) and Ben-Men-1 cells (IC50 ~1 μM). The G2/M population increased in both Sch10545 and Ben-Men-1 cells treated with cucurbitacin D or goyazensolide around the IC50. Cucurbitacin and goyazensolide substantially reduced the levels of cyclins E and A in treated Sch10545 and Ben-Men-1 cells. Cucurbitacin D also inhibited cyclin B, phospho-AKT and phospho-PRAS40 expression. In addition, goyazensolide reduced the levels of phospho-AKT and NFκB and increased the expression of pro-apoptotic Bim in Sch10545 and Ben-Men-1 cells. Conclusions Both cucurbitacin D and goyazensolide effectively inhibit proliferation of NF2-deficient schwannoma and meningioma cells, suggesting that these natural compounds should be further evaluated as potential treatments for NF2-related tumors. PMID:23928514

  10. Post-transplant bendamustine reduces GvHD while preserving GvL in experimental haploidentical bone marrow transplantation.

    PubMed

    Stokes, Jessica; Hoffman, Emely A; Zeng, Yi; Larmonier, Nicolas; Katsanis, Emmanuel

    2016-07-01

    Advances in haploidentical bone marrow transplantation (h-BMT) have drastically broadened the treatment options for patients requiring BMT. The possibility of significantly reducing the complications resulting from graft-versus-host disease (GvHD) with the administration of post-transplant cyclophosphamide (PT-CY) has substantially improved the efficacy and applicability of T cell-replete h-BMT. However, higher frequency of disease recurrence remains a major challenge in h-BMT with PT-CY. There is a critical need to identify novel strategies to prevent GvHD while sparing the graft-versus-leukaemia (GvL) effect in h-BMT. To this end, we evaluated the impact of bendamustine (BEN), given post-transplant, on GvHD and GvL using clinically relevant murine h-BMT models. We provide results indicating that post-transplant bendamustine (PT-BEN) alleviates GvHD, significantly improving survival, while preserving engraftment and GvL effects. We further document that PT-BEN can mitigate GvHD even in the absence of Treg. Our results also indicate that PT-BEN is less myelosuppressive than PT-CY, significantly increasing the number and proportion of CD11b(+) Gr-1(hi) cells, while decreasing lymphoid cells. In vitro we observed that BEN enhances the suppressive function of myeloid-derived suppressor cells (MDSCs) while impairing the proliferation of T- and B-cells. These results advocate for the consideration of PT-BEN as a new therapeutic platform for clinical implementation in h-BMT. PMID:27030315

  11. NASA Lewis and Ohio Company Hit Hole in One

    NASA Technical Reports Server (NTRS)

    1998-01-01

    Ben Hogan Company's Golf Ball Division, which is based in Elyria, Ohio, had developed concepts and prototypes for new golf balls but was unable to determine exact performance characteristics. Specifically, the company's R&D department wanted to measure the spin rates of experimental golf balls. After the Golf Ball Division requested assistance, researchers and technicians from the NASA Lewis Research Center went to Elyria and conducted several days worth of tests. Ben Hogan is using the test results to improve the spin characteristics of a new ball it plans to introduce to the market.

  12. Dual delivery systems based on polyamine analog BENSpm as prodrug and gene delivery vectors

    NASA Astrophysics Data System (ADS)

    Zhu, Yu

    Combination drug and gene therapy shows promise in cancer treatment. However, the success of such strategy requires careful selection of the therapeutic agents, as well as development of efficient delivery vectors. BENSpm (N 1, N11-bisethylnorspermine), a polyamine analogue targeting the intracellular polyamine pathway, draws our special attention because of the following reasons: (1) polyamine pathway is frequently dysregulated in cancer; (2) BENSpm exhibits multiple functions to interfere with the polyamine pathway, such as to up-regulate polyamine metabolism enzymes and down-regulate polyamine biosynthesis enzymes. Therefore BENSpm depletes all natural polyamines and leads to apoptosis and cell growth inhibition in a wide range of cancers; (3) preclinical studies proved that BENSpm can act synergistically with various chemotherapy agents, making it a promising candidate in combination therapy; (4) multiple positive charges in BENSpm enable it as a suitable building block for cationic polymers, which can be further applied to gene delivery. In this dissertation, our goal was to design dual-function delivery vector based on BENSpm that can function as a gene delivery vector and, after intracellular degradation, as an active anticancer agent targeting dysregulated polyamine metabolism. We first demonstrated strong synergism between BENSpm and a potential therapeutic gene product TRAIL. Strong synergism was obtained in both estrogen-dependent MCF-7 breast cancer cells and triple-negative MDA-MB-231 breast cancer cells. Significant dose reduction of TRAIL in combination with BENSpm in MDA-MB-231 cells, together with the fact that BENSpm rendered MCF-7 cells more sensitive to TRAIL treatment verified our rationale of designing BENSpm-based delivery platform. This was expected to be beneficial for overcoming drug resistance in chemotherapy, as well as boosting the therapeutic effect of therapeutic genes. We first designed a lipid-based BENSpm dual vector (Lipo-SS-BEN

  13. Benjamin P. Flower (1962-2012)

    NASA Astrophysics Data System (ADS)

    Hastings, David W.; Shevenell, Amelia E.; Kennett, James P.

    2012-10-01

    Benjamin P. Flower, a gifted paleoceanographer and marine geologist, supportive colleague, and dedicated educator at the University of South Florida (USF) College of Marine Science (CMS) passed away on 1 July 2012 from complications related to a rare genetic immune dysfunction, Common Variable Immunodeficiency. He was 49 years old. During his brief illness, Ben's love of life and boundless high spirits were an inspiration to his family, friends, and colleagues. He exhibited remarkable courage and kept his sense of humor in face of adversity. Ben's intellectualism and enduring love of science remained intact, even in his last hours.

  14. Generation of broadband electrostatic noise by electron acoustic solitons

    SciTech Connect

    Dubouloz, N.; Pottelette, R.; Malingre, M. ); Treumann, R.A. )

    1991-02-01

    Broadband electrostatic noise (BEN) bursts whose amplitude sometimes reaches about 100 mV m{sup {minus}1} have been observed by the Viking satellite in the dayside auroral zone. These emissions have been shown to be greatly influenced by nonlinear effects and to occur simultaneously with the observation of particle distributions favouring the destabilization of the electron acoustic mode. It is shown that electron acoustic solitons passing by the satellite would generate spectra that can explain the high-frequency part of BEN, above the electron plasma frequency.

  15. Dormancy release and flowering time in Ziziphus jujuba Mill., a "direct flowering" fruit tree, has a facultative requirement for chilling.

    PubMed

    Meir, Michal; Ransbotyn, Vanessa; Raveh, Eran; Barak, Simon; Tel-Zur, Noemi; Zaccai, Michele

    2016-03-15

    In deciduous fruit trees, the effect of chilling on flowering has mostly been investigated in the "indirect flowering" group, characterized by a period of rest between flower bud formation and blooming. In the present study, we explored the effects of chilling and chilling deprivation on the flowering of Ziziphus jujuba, a temperate deciduous fruit tree belonging to the "direct flowering" group, in which flower bud differentiation, blooming and fruit development occur after dormancy release, during a single growing season. Dormancy release, vegetative growth and flowering time in Z. jujuba cv. Ben-Li were assessed following several treatments of chilling. Chilling treatments quantitatively decreased the timing of vegetative bud dormancy release, thereby accelerating flowering, but had no effect on the time from dormancy release to flowering. Trees grown at a constant temperature of 25°C, without chilling, broke dormancy and flowered, indicating the facultative character of chilling in this species. We measured the expression of Z. jujuba LFY and AP1 homologues (ZjLFY and ZjAP1). Chilling decreased ZjLFY expression in dormant vegetative buds but had no effect on ZjAP1expression, which reached peak expression before dormancy release and at anthesis. In conclusion, chilling is not obligatory for dormancy release of Z. jujuba cv. Ben-Li vegetative buds. However, the exposure to chilling during dormancy does accelerate vegetative bud dormancy release and flowering. PMID:26949231

  16. Detection of Overreported Psychopathology with the MMPI-2 RF Form Validity Scales

    ERIC Educational Resources Information Center

    Sellbom, Martin; Bagby, R. Michael

    2010-01-01

    We examined the utility of the validity scales on the recently released Minnesota Multiphasic Personality Inventory-2 Restructured Form (MMPI-2 RF; Ben-Porath & Tellegen, 2008) to detect overreported psychopathology. This set of validity scales includes a newly developed scale and revised versions of the original MMPI-2 validity scales. We used an…

  17. Further Validation of the MMPI-2 And MMPI-2-RF Response Bias Scale: Findings from Disability and Criminal Forensic Settings

    ERIC Educational Resources Information Center

    Wygant, Dustin B.; Sellbom, Martin; Gervais, Roger O.; Ben-Porath, Yossef S.; Stafford, Kathleen P.; Freeman, David B.; Heilbronner, Robert L.

    2010-01-01

    The present study extends the validation of the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) and the Minnesota Multiphasic Personality Inventory-2 Restructured Form (MMPI-2-RF) Response Bias Scale (RBS; R. O. Gervais, Y. S. Ben-Porath, D. B. Wygant, & P. Green, 2007) in separate forensic samples composed of disability claimants and…

  18. A Replication of the MMPI-A PSY-5 Scales and Development of Facet Subscales

    ERIC Educational Resources Information Center

    Bolinskey, P. Kevin; Arnau, Randolph C.; Archer, Robert P.; Handel, Richard W.

    2004-01-01

    McNulty, Harkness, Ben-Porath and Williams recently developed Personality Psychopathology Five (PSY-5) scales for the Minnesota Multiphasic Personality Inventory A (MMPI-A). This study examined these new scales in a sample of 545 adolescents receiving inpatient psychiatric treatment. Item-level principal components analyses were employed to…

  19. Managing Osteoarthritis Pain with Medicines: A Review of the Research for Adults

    MedlinePlus

    ... to you, like Advil ® , Motrin ® , Aleve ® , and Celebrex ® . Skin creams: Common brand names include BenGay ® , Aspercreme ® , or Theragen ® . ... these medicines reduce pain better than acetaminophen. Diclofenac skin cream works as well as NSAID pills. All of ...

  20. Does Topic Familiarity Affect Assessed Difficulty and Actual Performance on Reading Comprehension Tests in LSP?

    ERIC Educational Resources Information Center

    Peretz, Arna S.; Shoham, Miriam

    A study investigated the hypothesis that topic familiarity and assessed difficulty of a second language text correlated positively with performance on reading comprehension tests in languages for special purposes (LSP). Subjects were 177 advanced students of English as a Foreign Language (EFL) at Ben Gurion University (Israel). Faculty from the…

  1. The "Day in the Life of a Teenage Hobo" Project: Integrating Technology with Shneiderman's Collect-Relate-Create- Donate Framework

    ERIC Educational Resources Information Center

    Reich, Justin; Daccord, Thomas

    2009-01-01

    Used wisely, academic technology empowers students to take responsibility for their own learning. "In Leonardo's Laptop," Ben Shneiderman provides teachers with a powerful framework, "Collect-Relate-Create-Donate" (CRCD), for designing student-centered learning opportunities using computers. Shneiderman developed his model by applying new insights…

  2. English Leadership Quarterly, 1994.

    ERIC Educational Resources Information Center

    Strickland, James, Ed.; Kiernan, Henry, Ed.

    1994-01-01

    These 4 issues of the English Leadership Quarterly comprise volume 16, published during 1994. Articles in number 1 deal with practical advice, and include: "The Law of Privacy and the Writing Teacher" (Ben T. Allen); Beware of Teachers Who Laminate Their Lesson Plans and Other Useful Suggestions about Teaching" (Robert Perrin); "Firefighter, Cook,…

  3. "I Didn't Used to Have Much Friends": Exploring the Friendship Concepts and Capabilities of a Boy with Autism and Severe Learning Disabilities

    ERIC Educational Resources Information Center

    Potter, Carol

    2015-01-01

    Whilst progress has been made in understanding the friendships of children with autism, research on the friendships of children with additional learning disabilities remains extremely limited. In this research, a qualitative case study approach provided a rich description of the friendship concepts and capabilities of Ben, a 10-year-old boy with…

  4. Comparison of thermal inactivation kinetics of E. coli K12 in apple cider using conventional glass tubes, aluminum thermal-death-time disks, and a pilot-scale pasteurizer

    Technology Transfer Automated Retrieval System (TEKTRAN)

    To estimate thermal inactivation rates of microorganisms in food, heating apparatuses of bench-top scale such as glass tubes, capillary tubes, and aluminum disks have been developed and tested. However, little work has been done on comparing the thermal inactivation of microorganisms obtained by ben...

  5. Effects of the bias enhanced nucleation hot-filament chemical-vapor deposition parameters on diamond nucleation on iridium

    NASA Astrophysics Data System (ADS)

    Arnault, J. C.; Schull, G.; Polini, R.; Mermoux, M.; Faerber, J.

    2005-08-01

    The effects of the bias current density and the filament-to-substrate distance on the nucleation of diamond on iridium buffer layers were investigated in a hot-filament chemical-vapor deposition (HFCVD) reactor. The nucleation density increased by several orders of magnitude with the raise of the bias current density. According to high-resolution field-emission gun scanning electron microscopy observation, diamond nuclei formed during bias-enhanced nucleation (BEN) did not show any preferred oriented growth. Moreover, the first-nearest-neighbor distance distribution was consistent with a random nucleation mechanism. This occurrence suggested that the diffusion of carbon species at the substrate surface was not the predominant mechanism taking place during BEN in the HFCVD process. This fact was attributed to the formation of a graphitic layer prior to diamond nucleation. We also observed that the reduction of the filament sample distance during BEN was helpful for diamond growth. This nucleation behavior was different from the one previously reported in the case of BEN-microwave chemical-vapor deposition experiments on iridium and has been tentatively explained by taking into account the specific properties and limitations of the HFCVD technique.

  6. Application of the “4R” nutrient stewardship concept to horticultural crops: getting nutrients in the “right” place

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The 4R nutrient stewardship concept was introduced in 2009 by International Plant Nutrition Institute to define the right source, rate, time, and place to apply fertilizers to produce not only the most economical outcome in any given crop but to also to provide desirable social and environmental ben...

  7. Exploring the Relationships among Race, Class, Gender, and Middle School Students' Perceptions of School Racial Climate

    ERIC Educational Resources Information Center

    Watkins, Natasha D.; Aber, Mark S.

    2009-01-01

    Although school climate has been thought to be especially important for racial minority and poor students (Booker, 2006; Haynes, Emmons, & Ben-Avie, 1997), little research has explored the significance of racial climate for these students. Furthermore, research in the area has tended to treat race, socioeconomic class, and gender separately,…

  8. Leadership Development in China: How the Companies Develop Their Leaders and What Critical Factors Contribute to Enhancing the Effectiveness of Leadership Development Practices

    ERIC Educational Resources Information Center

    Qiao, June Xuejun; Rothwell, William J.; Vicere, Albert A.

    2007-01-01

    This study investigated how companies in China develop their leaders and what critical factors contribute to enhancing the effectiveness of leadership development practices. This study adopted a multiple-case study design. Four companies--ABB, BenQ, Lenovo and Motorola were studied. The findings suggest that the four companies in China develop…

  9. Framework for automated spatio-temporal enhancement of coarse resolution leaf area index (FASE-LAI) – Application to MODIS LAI

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A multi-scale satellite-based Framework for Automated Spatio-temporal Enhancement of coarse-resolution leaf area index (LAI) products (FASE-LAI) has ben established to generate 4-day time-series of Landsat-scale LAI, thereby meeting the critical demands of applications needing frequent and high spat...

  10. Finding a Light

    ERIC Educational Resources Information Center

    Lang, James M.

    2007-01-01

    In this article, the author passes along a few pieces of advice from "Tips and Thoughts on Improving the Teaching Process in College: A Personal Diary," a self-published book by Joe Ben Hoyle, an associate professor of accounting at the University of Richmond. He excerpts five tips from the 34 in the book, each of which comes wrapped in a pleasing…

  11. Hey! A Tarantula Bit Me!

    MedlinePlus

    ... leave you alone. Reviewed by: Elana Pearl Ben-Joseph, MD Date reviewed: April 2013 For Teens For Kids For Parents MORE ON THIS TOPIC Hey! A Fire Ant Stung Me! Hey! A Scorpion Stung Me! Hey! A Black Widow Spider Bit Me! Hey! A Brown Recluse ...

  12. Hey! A Brown Recluse Spider Bit Me!

    MedlinePlus

    ... putting them on. Reviewed by: Elana Pearl Ben-Joseph, MD Date reviewed: April 2013 For Teens For Kids For Parents MORE ON THIS TOPIC Hey! A Fire Ant Stung Me! Hey! A Tarantula Bit Me! Hey! A Scorpion Stung Me! Hey! A Black Widow Spider Bit Me! Camping and Woods Safety ...

  13. Hey! A Scorpion Stung Me!

    MedlinePlus

    ... putting them on. Reviewed by: Elana Pearl Ben-Joseph, MD Date reviewed: April 2013 For Teens For Kids For Parents MORE ON THIS TOPIC Hey! A Fire Ant Stung Me! Hey! A Gnat Bit Me! Hey! A Tarantula Bit Me! Hey! A Bee Stung Me! Hey! A Black Widow Spider Bit Me! Hey! A Mosquito Bit ...

  14. Innovative Schools in Michigan. Connect: Making Learning Personal

    ERIC Educational Resources Information Center

    Page, Stephen F., Ed.

    2015-01-01

    This second issue of "Connect" highlights innovative teaching as practiced by teachers and administrators in Michigan schools as they seek to provide greater personalization for every student's learning. Nicholas Provenzano and Ben Gilpin give field reports from their schools, which have implemented a version of 20-Time--a concept…

  15. The Fed's Year of Transition

    ERIC Educational Resources Information Center

    Schug, Mark C.; Niederjohn, Scott

    2006-01-01

    The purpose of this article is to: (1) Examine the historical development of the Federal Reserve System; (2) Provide background on Ben Bernanke, the new Fed chairman; (3) Explain the basic tools of monetary policy used by the Fed; (4) Examine the causes of the Great Depression, a topic of special interest to Bernanke; and (5) Provide some key…

  16. Varia. (Miscellany).

    ERIC Educational Resources Information Center

    Matthey, Marinette

    1996-01-01

    This collection of diverse research papers in linguistics includes: "La notion de tour de parole dans une perspective syntaxique" ("The Notion of Turn Taking from a Syntactic Perspective") (Jean-Marc Luscher, Sandrine Piaget, Christian Rubattel); "'Si tu me fais honneur d'un p'tit telephone demain matin ben je suis contente': Structure des…

  17. An Analysis of the Impacts of the AIR Funding Formula Proposal on New Mexico School Districts

    ERIC Educational Resources Information Center

    Johnson, Jerry; Strange, Marty

    2009-01-01

    This report of the Rural School and Community Trust and the Ben Lujan Leadership and Public Policy Institute presents findings from an investigation of the impact of the funding formula proposal commissioned by the New Mexico Funding Formula Task Force (FFTF) and developed by American Institutes of Research (AIR). Appointed by the New Mexico…

  18. More High School Graduates: How Schools Can Save Students from Dropping Out

    ERIC Educational Resources Information Center

    Levin, Ben

    2012-01-01

    "More High School Graduates" is a comprehensive guide for school leaders and government policymakers committed to boosting high school graduation rates. Drawing from his knowledge as an education official and professor, author Ben Levin presents a system to turn around secondary schools that is adaptable for local-, district-, and state-level…

  19. Potential population-level effects of land-use change and climate change

    EPA Science Inventory

    Climate change and land-use change are poised to be two fo the largest drivers of biological changeover the next century. We explored the potential effects of these two forces on a population of Red-cockaded Woodpeckers (Picoides borealis) at Fort Benning in Georgia, USA. We us...

  20. An Experimental Evaluation of Stress-Management Training for the Airborne Soldier. Technical Report 550.

    ERIC Educational Resources Information Center

    Burke, William P.

    A project was conducted to evaluate the effectiveness of the stress-management training given to students in the jumpmaster training course at Fort Benning, Georgia. The course, which trains airborne personnel to conduct landings of men and equipment, features relatively stressful training programs during which instructors grade the performance of…

  1. Cognitive Congruence between Teachers' Questions and Students' Answers.

    ERIC Educational Resources Information Center

    Neumann, Lily; Mahler, Sophia

    1989-01-01

    A study assessed the impact of a teacher-training workshop at Israel's Ben Gurion University's medical school which focused on classroom interaction. Results of the workshop indicated verbal teacher-student interactions significantly outnumbered individual statements; interactions increased, especially in larger classes; cognitive correspondence…

  2. Short and Long Term Effects of Teacher-Training Workshop in Medical School.

    ERIC Educational Resources Information Center

    Mahler, Sophia; Benor, Dan E.

    A study measured both short- and long-term effects of an educational workshop designed for teachers in the Faculty of Health Sciences, Ben-Gurion, Israel. Participants were 60 volunteer faculty members who were randomly assigned to one of eight multidisciplinary groups for the 4-day workshop, which aimed at improving teachers' instructional…

  3. Changes in the Rhythm of Lessons Following a Teacher-Training Workshop in Medical School.

    ERIC Educational Resources Information Center

    Mahler, Sophia; And Others

    A study examined both cognitive and activity rhythms of lessons in a variety of disciplines and teaching styles in the medical school curriculum among 20 faculty members at Ben Gurion University, Israel. Studied were changes which occurred in the rhythms following a teacher training program, and interrelationship among rhythms and size of learning…

  4. Elevation of south facade. The twostory structure to the right ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Elevation of south facade. The two-story structure to the right of the J.C. Lore Oyster House houses the F. & H. Benning Company Oyster Mill, see HAER No. MD-135. - J.C. Lore Oyster House, 14430 Solomons Island Road, Solomons, Calvert County, MD

  5. Elevation of waterfront facade looking west. The twostory structure at ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Elevation of waterfront facade looking west. The two-story structure at the left houses the F. & H. Benning Company Mill and is not part of the J.C. Lore Oyster House. - J.C. Lore Oyster House, 14430 Solomons Island Road, Solomons, Calvert County, MD

  6. Principal Components Analyses of the MMPI-2 PSY-5 Scales. Identification of Facet Subscales

    ERIC Educational Resources Information Center

    Arnau, Randolph C.; Handel, Richard W.; Archer, Robert P.

    2005-01-01

    The Personality Psychopathology Five (PSY-5) is a five-factor personality trait model designed for assessing personality pathology using quantitative dimensions. Harkness, McNulty, and Ben-Porath developed Minnesota Multiphasic Personality Inventory-2 (MMPI-2) scales based on the PSY-5 model, and these scales were recently added to the standard…

  7. Validity of the MMPI-2-RF (Restructured Form) L-r and K-r Scales in Detecting Underreporting in Clinical and Nonclinical Samples

    ERIC Educational Resources Information Center

    Sellbom, Martin; Bagby, R. Michael

    2008-01-01

    In the current investigation, the authors examined the validity of the L-r and K-r scales on the recently developed Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF; Y. S. Ben-Porath & A. Tellegen, in press) in measuring underreported response bias. Three archival samples previously collected for examining MMPI-2 validity…

  8. Hey! A Flea Bit Me!

    MedlinePlus

    ... to keep the flea population down. Wearing an insect repellent also may help. Ask your parents to apply one that contains 10%–30% DEET. Reviewed by: Elana Pearl Ben-Joseph, MD Date reviewed: September ... Getty Images, Corbis, Veer, Science Photo Library, Science Source Images, Shutterstock, and Clipart.com

  9. A Place for Individual Enquiry? Why We Would Miss Controlled Assessments in History

    ERIC Educational Resources Information Center

    Fowle, Mark; Egelnick, Ben

    2013-01-01

    Most history teachers will, at some point, recognise the tension between teaching an engaging history course while at the same time meeting the requirements of an exam specification. Mark Fowle and Ben Egelnick reflect here on how they approached teaching a formal requirement of an exam specification. Rather than see "controlled…

  10. APPLICATION OF NIR FOR RAPID WHAT QUALITY ANALYSIS

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Since the development of the first computerized near-infrared (NIR) spectrometer by I. Ben-Gera and K. Norris (USDA) in 1968 for the measurement of moisture in meat products, NIR spectroscopy has seen an unprecedented growth in its use, not only in agricultural products but also in many different an...

  11. Blast Off! The Team America Rocketry Challenge

    ERIC Educational Resources Information Center

    Peckham, Susanne

    2009-01-01

    This article features the team of students from Madison (Wisconsin) West High School who took first place in the Seventh Annual Team America Rocketry Challenge (TARC), earning the title of national champion. The four-member team--Jacqui German, Tenzin Sonam, John Schoech, and Ben Winokur--spent several months perfecting their design after the…

  12. 77 FR 34887 - Substantial Business Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-12

    ... to: CC:PA:LPD:PR (REG-107889-12), room 5203, Internal Revenue Service, PO Box 7604, Ben Franklin... of 8 a.m. and 4 p.m. to CC:PA:LPD:PR (REG- 107889-12), Courier's Desk, Internal Revenue Service,...

  13. Older People and Their Attitude to the Use of Information and Communication Technologies--A Review Study with Special Focus on the Czech Republic (Older People and Their Attitude to ICT)

    ERIC Educational Resources Information Center

    Klimova, Blanka; Simonova, Ivana; Poulova, Petra; Truhlarova, Zuzana; Kuca, Kamil

    2016-01-01

    Rising standards of living and good quality health care have contributed to people living longer. According to the Eurostat agency (Benácová & Valenta, 2009), in the next 50 years there will be twice as many older people worldwide. The aging process, however, brings about new economic and social issues. Therefore, there is constant effort to…

  14. Mark Twain and the American Myth.

    ERIC Educational Resources Information Center

    Calisch, Richard

    1986-01-01

    Discusses how traditional character types (such as Rip Van Winkle, the Ben Franklin character, and the Great Puritan) that Twain criticized through his satire survived his attacks and can be found today in many kinds of literature, including film and television. (SRT)

  15. Coming to a hospital near you: mass spectrometry imaging

    ScienceCinema

    Bowen, Ben

    2014-06-24

    Berkeley Lab's Ben Bowen discusses "Coming to a hospital near you: mass spectrometry imaging" in this Oct. 28, 2013 talk, which is part of a Science at the Theater event entitled Eight Big Ideas. Go here to watch the entire event with all 8 speakers.

  16. Israel's Interdisciplinary Center Draws Praise for Its International Outlook

    ERIC Educational Resources Information Center

    Kalman, Matthew

    2009-01-01

    Tal Ben-Shahar was once a successful psychology professor at Harvard University. His classes on positive psychology attracted audiences of more than 850 students, making it the most popular course on the campus. But the best-selling author of "Heaven Can Wait" and "Happier" left America in 2006 to return to his native Israel and teach at a…

  17. 75 FR 61664 - Endangered and Threatened Wildlife and Plants; Endangered Status for the Altamaha Spinymussel and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-06

    ...We, the U.S. Fish and Wildlife Service, propose to list the Altamaha spinymussel (Elliptio spinosa), a freshwater mussel endemic to the Altamaha River drainage of southeastern Georgia, as an endangered species under the Endangered Species Act of 1973, as amended (Act), and to designate approximately 240 kilometers (149 miles) of mainstem river channel as critical habitat in Appling, Ben Hill,......

  18. Testimony Presented at an Open Hearing of the National Commission on Excellence in Teacher Education (Austin, Texas, October 4-5, 1984).

    ERIC Educational Resources Information Center

    1984

    Testimony was presented on various issues of restoring excellence to education. The following papers are included in this document: (1) "The Neglected Obligation of the Teaching Profession" (Richard Swain); (2) "Instructional Supervision for Excellence in Education" (Ben M. Harris); (3) "Competency Testing: Excellence without Equity" (G. Pritchy…

  19. Taking Flight Internationally

    ERIC Educational Resources Information Center

    Roach, Ronald

    2007-01-01

    This article describes how Dr. Ben Vinson III, the new director of the Center for Africana Studies at Johns Hopkins University and a specialist in Latin American history, is strengthening the center's internationalist orientation. While it took more than three decades for Johns Hopkins University to approve a Black studies program in its arts and…

  20. Sprechen Sie Physik?

    NASA Astrophysics Data System (ADS)

    Lamden, Ralph J.

    2009-07-01

    Ben Stein's article about the use of the German language in physics (April pp16-17) reminds me that when I started an honours physics degree at Manchester University in 1949, a qualification in German was a requirement for the course. At that time Zeitschrift für Physik was a notable journal that had to be read in the original German.

  1. Business Ethics: A View from the Classroom

    ERIC Educational Resources Information Center

    Galbraith, Diane D.; Webb, Fred L.

    2010-01-01

    The global economy has been devastated in the last year and according to Federal Reserve Chairman, Ben Bernanke, America's economy was threatened, reminiscent of the Great Depression. Our nation is also in a serious ethical and moral decline, as evidenced by steroid use in baseball, corporate scandals, accounting fraud, religious immorality within…

  2. The Business Case for Sustainability

    ERIC Educational Resources Information Center

    Freese, Walt

    2007-01-01

    Sustainability is an evolving and often misused word in business. As the landscape changes in terms of how resources are evaluated, so does the context of sustainability. In the most general terms, Ben & Jerry's looks at sustainability from the perspective of the social and environmental resources. Improper use of the term has been called "green…

  3. Chemical lake restoration products: sediment stability and phosphorus dynamics.

    PubMed

    Egemose, Sara; Reitzel, Kasper; Andersen, Frede Ø; Flindt, Mogens R

    2010-02-01

    Laboratory experiments with sediments from three shallow Danish lakes were conducted to evaluate the effects of chemical lake restoration products during resuspension. Phosphorus (P) removal, sediment stability, sediment consolidation and color reduction were studied over time. The investigated products were aluminum (Al), Phoslock (a commercial bentonite product coated with lanthanum) and a combination of Al covered with bentonite (Al/Ben). All treatments effectively reduced the P concentration in the water. However, the treatments containing Al reduced the P concentration immediately after resuspension, whereas Phoslock required several days after resuspension to reduce the P concentration. Especially Phoslock, but also Al/Ben, increased the sediment stability threshold by 265% and 101%, respectively, whereas Al had no stabilizing effect. The fresh Al floc was resuspended 5x easier than untreated sediment. The largest consolidation of the sediment occurred with addition of Phoslock, followed by Al/Ben, while Al alone had no effect. Enhanced consolidation may be of importance for macrophyte colonisation of organic sediment. Phoslock improved the light climate moderately by removing color, whereas Al was very effective in removing color. Ben/Al showed intermediate effects on color reduction. These findings are important when decisions are made on restoration method for a specific lake, which may be more or less wind exposed. PMID:20055487

  4. 78 FR 35951 - Proposed Low-Effect Habitat Conservation Plan for the City of Santa Cruz Graham Hill Water...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-14

    ... endangered Zayante band winged grasshopper (Trimerotropis infantilis), and will address associated impacts... take of Mount Hermon June beetle and Zayante band-winged grasshopper. Associated impacts and... grasshopper were listed by the U.S. Fish and Wildlife Service as endangered on January 1, 1997. The Ben...

  5. Package Deal

    ERIC Educational Resources Information Center

    Ford, William J.

    2012-01-01

    This article features the Higher Education Recruitment Consortium, or HERC, website, which lists all positions such as custodians, administrators, and other faculty positions at colleges, universities, and research institutions throughout the country. HERC, based in Ben Lomond, California, uses its "dual career" hiring services to help couples…

  6. Philosophy and Empirical Evidence: Achieving Vision through Research

    ERIC Educational Resources Information Center

    Ben-Avie, Michael; Comer, James P.

    2005-01-01

    Ben-Avie and Comer describe how Jewish day schools and the Yale Child Study Center's School Development Program (SDP) share a common agenda regarding the aim of education. The foundational science of education is child development, advocates James P. Comer in such seminal works as "School Power" (1980) and "Waiting For A Miracle" (1998). SDP, the…

  7. Key Qualifications in Work and Education.

    ERIC Educational Resources Information Center

    Nijhof, Wim J., Ed.; Streumer, Jan N., Ed.

    This book contains the following chapters: "The Demarcation Issue: Introduction" (Wim J. Nijhof, Jan N. Streumer); "Qualifying for the Future" (Wim J. Nijhof); "The Many Meanings of Occupational Competence and Qualification" (Per-Erik Ellstroem); "Qualification and Labour Markets: Institutionalisation and Individualisation" (Ben Hoevels); "The…

  8. Controlling Cancer: Choices for a Healthy Life. Hearing before the Select Committee on Aging. House of Representatives, Ninety-Ninth Congress, First Session (Cranston, RI).

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Select Committee on Aging.

    This paper contains testimony and prepared statements from the Congressional hearing called to examine ways of controlling cancer. Opening statements are included from Representatives Claudine Schneider, Jim Lightfoot, and Ben Blaz. Testimonies are given by Rosemarie Lindgren, a homemaker and former cancer patient, and by Jules Cardin, a patient…

  9. Study shows reduction in death for men with intermediate-grade prostate cancer

    Cancer.gov

    Short-term hormone therapy given in combination with radiation therapy to men with early-stage prostate cancer increased their chances of living longer compared to treatment with radiation therapy alone, according to a clinical trial supported by NCI. Ben

  10. Ácaros del mango

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Los ácaros constituyen un grupo abundante y diverso que ocupa diferentes hábitats en árboles frutales y la estructura y disposición del follaje y ramas del mango, contribuyen significativamente a que se presente gran diversidad de ácaros benéficos y dañinos asociados a esta especie frutal. En Colomb...

  11. None So Blind: Early Childhood Education and Care--The Connective Tissue

    ERIC Educational Resources Information Center

    Gammage, Philip

    2007-01-01

    The author makes sense of the story of his professional life through the eyes of several important writers and teachers on education and says that, for him, Bridget Plowden ranks alongside John Dewey, Friedrich Froebel, Ben Morris and A.S. Neill.

  12. Factor Structure of the Psychopathic Personality Inventory (PPI): Findings from a Large Incarcerated Sample

    ERIC Educational Resources Information Center

    Neumann, Craig S.; Malterer, Melanie B.; Newman, Joseph P.

    2008-01-01

    Exploratory factor analysis (EFA) of the Psychopathic Personality Inventory (PPI; S. O. Lilienfeld, 1990; S. O. Lilienfeld & B. P. Andrews, 1996) with a community sample has suggested that the PPI subscales may comprise 2 higher order factors (S. D. Benning, C. J. Patrick, B. M. Hicks, D. M. Blonigen, & R. F. Krueger, 2003). However, substantive…

  13. 75 FR 33740 - Indoor Tanning Services; Cosmetic Services; Excise Taxes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-15

    ... Internal Revenue Service 26 CFR Parts 40 and 49 RIN 1545-BJ40 Indoor Tanning Services; Cosmetic Services; Excise Taxes AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice of proposed rulemaking by...-112841-10), Room 5203, Internal Revenue Service, P.O. Box 7604, Ben Franklin Station, Washington,...

  14. The Community College System in North Carolina: A Silver Anniversary History, 1963-1988.

    ERIC Educational Resources Information Center

    Wiggs, Jon Lee

    Documenting the 25-year history of the North Carolina Community College System (NCCCS), this book focuses on each of the successive academic terms from 1963-64 to 1987-88. The chapters are grouped into five sections, corresponding to the lengths of tenure of the five NCCCS presidents: the (Isaac) Ready years from 1963 to 1970; the (Ben) Fountain…

  15. Science and Education across Cultures: Another Look at the Negev Bedouins and Their Environmental Management Practices

    ERIC Educational Resources Information Center

    Saito, Carlos Hiroo

    2014-01-01

    This is a rejoinder to the original article written by Wisam Sedawi, Orit Ben Zvi Assaraf, and Julie Cwikel about waste-related implication on the welfare of children living in the Negev's Bedouin Arab community. More specifically, the authors discuss the role of environmental education in the improvement of participants' life…

  16. Utility of the MMPI-2-RF (Restructured Form) Validity Scales in Detecting Malingering in a Criminal Forensic Setting: A Known-Groups Design

    ERIC Educational Resources Information Center

    Sellbom, Martin; Toomey, Joseph A.; Wygant, Dustin B.; Kucharski, L. Thomas; Duncan, Scott

    2010-01-01

    The current study examined the utility of the recently released Minnesota Multiphasic Personality Inventory-2 Restructured Form (MMPI-2-RF; Ben-Porath & Tellegen, 2008) validity scales to detect feigned psychopathology in a criminal forensic setting. We used a known-groups design with the Structured Interview of Reported Symptoms (SIRS; Rogers,…

  17. Successful Education Research: Guidelines for Getting Going, Getting Funded and Getting Published

    ERIC Educational Resources Information Center

    Deacon, Roger; Parker, Ben

    2009-01-01

    As part of the Teacher Education Research and Development Programme (TEP), a project focusing on "Stimulation of practice-based teacher education research", was undertaken by Dr. Roger Deacon and Dr. Ben Parker, in conjunction with the Centre for Education Policy Development (CEPD). As part of the project, a set of research guidelines entitled,…

  18. VALUING ACID MINE DRAINAGE REMEDIATION IN WEST VIRGINIA: BENEFIT TRANSFER WITH PREFERENCE CALIBRATION

    EPA Science Inventory

    Several thousand kilometers of West Virginia streams are degraded by acid mine drainage (AMD), and the estimates for cleanup range in the billions of dollars. Not enough money is available to restore all the affected streams, so some way to prioritize those streams is needed. Ben...

  19. The New Campus, 1980. Volume 33.

    ERIC Educational Resources Information Center

    Hackler, George, Ed.; And Others

    1980-01-01

    This issue of "The New Campus" contains 14 articles that allude to or deal directly with the quality of continuing education programs. Articles and authors are as follows: "A Study of the Use of an SCA-FM Broadcast System for Teacher Inservice Education" (Charles Koelling and Richard Robinson); "The Changing Role of Adult Education" (Ben J.…

  20. Self-Immolative Polycations as Gene Delivery Vectors and Prodrugs Targeting Polyamine Metabolism in Cancer

    PubMed Central

    2015-01-01

    Polycations are explored as carriers to deliver therapeutic nucleic acids. Polycations are conventionally pharmacological inert with the sole function of delivering therapeutic cargo. This study reports synthesis of a self-immolative polycation (DSS-BEN) based on a polyamine analogue drug N1,N11-bisethylnorspermine (BENSpm). The polycation was designed to function dually as a gene delivery carrier and a prodrug targeting dysregulated polyamine metabolism in cancer. Using a combination of NMR and HPLC, we confirm that the self-immolative polycation undergoes intracellular degradation into the parent drug BENSpm. The released BENSpm depletes cellular levels of spermidine and spermine and upregulates polyamine catabolic enzymes spermine/spermidine N1-acetyltransferase (SSAT) and spermine oxidase (SMO). The synthesized polycations form polyplexes with DNA and facilitate efficient transfection. Taking advantage of the ability of BENSpm to sensitize cancer cells to TNFα-induced apoptosis, we show that DSS-BEN enhances the cell killing activity of TNFα gene therapy. The reported findings validate DSS-BEN as a dual-function delivery system that can deliver a therapeutic gene and improve the outcome of gene therapy as a result of the intracellular degradation of DSS-BEN to BENSpm and the subsequent beneficial effect of BENSpm on dysregulated polyamine metabolism in cancer. PMID:25153488

  1. Exhibitions in Sight

    ERIC Educational Resources Information Center

    Wasserman, Burton

    1978-01-01

    During this past year a vast number of art shows have been exhibited across the United States. Their most striking features were their range and diversity. Here are some comments on Ben Shahn's paintings and photography focusing on social realism, some works by the Polish Constructivists, interested in redefining form in relation to space, the…

  2. 78 FR 8060 - Treatment of Grantor of an Option on a Partnership Interest

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-05

    ... (noncompensatory partnership option regulations) were published in the Federal Register (68 FR 2930). Final...: CC:PA:LPD:PR (REG-106918-08), room 5203, Internal Revenue Service, PO Box 7604, Ben Franklin Station... Sec. 1.761-3, Benjamin Weaver at (202) 622-3050; concerning the proposed regulations under Sec....

  3. 76 FR 20593 - Guidance Under Section 108(a) Concerning the Exclusion of Section 61(a)(12) Discharge of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-13

    ... submissions to: CC:PA:LPD:PR (REG-154159-09), Room 5203, Internal Revenue Service, P.O. Box 7604, Ben Franklin...://www.regulations.gov (IRS REG-154159-09). FOR FURTHER INFORMATION CONTACT: Bryan A. Rimmke or Benjamin... these regulations are Bryan A. Rimmke and Benjamin H. Weaver, Office of the Associate Chief...

  4. Did I Grow up Just to Stay Home?

    ERIC Educational Resources Information Center

    Reynolds, Geoffrey A.

    2009-01-01

    This article focuses on the background of the English duo Everything but the Girl (EBTG). EBTG was formed in 1982 in Hull, England, consisting of Tracey Thorn (lead singer, sometimes guitar) and Ben Watt (guitar, keyboard, and vocal). Their music includes: alternative, dance, electronica, lounge, and pop.

  5. [Carving and spread of Xu Shuwei's medical books in the Southern Song Dynasty].

    PubMed

    Zhang, Haipeng

    2015-09-01

    Xu Shuwei's Pu ji ben shi fang (Moxibustion in Prescription for Universal Relief) was carved for several times and disseminated to Hubei, Hunan, Zhejiang, Jiangsu, Fujian, Sichuan Provinces and the areas under the rule of the Jin ethnic minority group. While Shang han bai zheng ge (Poets of Syndrome of Exo-pathogenic Cold disease), Shang han fa wei lun (Discourse on Elucidation of Exo-pathogenic Cold Disease), and Shang han jiu shi lun (90 Discourses on Exo-pathogenic Disease) were scarcely carved or spread in its copying form with very limited distribution. Hence, Pu ji ben shi fang exerts greater influence in the Southern Song Dynasty. When analysing the citations from the Pu ji ben sgiu fang in the books of the Southern Song Dynasty, very few texts were cited from Pu ji ben shi fang. Thus, in terms of knowledge on exo-pathogenic cold disease in the Southern Song Dynasty, Xu's influence was quite limited even though he himself had deep insight into this art of disease. PMID:26813096

  6. Psychological Treatment as Part of Dropout Prevention: An Israeli Program

    ERIC Educational Resources Information Center

    Schwartz, Hava; Hain, Rebecca

    2014-01-01

    This article reports on the integration of psychotherapy in a comprehensive dropout prevention program developed at the Dean of Students' office of Ben-Gurion University of the Negev in Israel. The program's psychologists conducted psychotherapy with a subset of dropout prevention program participants who had reacted with emotional…

  7. Q & A with Carmella Van Vleet

    ERIC Educational Resources Information Center

    Curriculum Review, 2008

    2008-01-01

    This article presents an interview with Carmella Van Vleet, a former teacher and educational speaker. She has written family humor and parenting articles, and is also the author of "How to Handle School Snafus," "Great Ancient Egypt Projects You Can Build Yourself" and "Amazing Ben Franklin Inventions You Can Build Yourself." In this interview,…

  8. The Deliberate Sabotage of Public Education by Liberal Elitists.

    ERIC Educational Resources Information Center

    Dixon, Greg

    1982-01-01

    Responding to Ben Brodinsky's article, the author declares that the New Right wants the schools turned back to the local school boards elected by the people so that the schools will reflect the moral standards of local communities. (Author/MLF)

  9. Material Specters: International Conflicts, Disaster Management, and Educational Projects

    ERIC Educational Resources Information Center

    Papastephanou, Marianna

    2011-01-01

    In this essay, Marianna Papastephanou discusses three books--Michalinos Zembylas's "The Politics of Trauma in Education"; Sigal Ben-Porath's "Citizenship Under Fire: Democratic Education in Times of Conflict"; and Kenneth Saltman's "Capitalizing on Disaster: Taking and Breaking Public Schools"--from the perspective of the material causality of…

  10. A test of self-stationarity

    USGS Publications Warehouse

    Regan, Robert D.

    1972-01-01

    A method for testing the stationarity of a single time series has been devised. The method utilizes two pre-existing tests of stationarity. A computer program that permits routine testing of any time series has been developed, and the test has ben successfully applied to several known series. In certain cases the self-stationarity determined can be equated to stationarity.

  11. Hepatic monooxygenase induction and promutagen activation in channel catfish from a contaminated river basin

    SciTech Connect

    Winston, G.W.; Shane, B.S.; Henry, C.B.

    1988-12-01

    To better understand the etiology of cancer in fish from polluted waters, the impact of environmental contaminants on xenobiotic metabolism of channel catfish (Ictalurus punctatus) from a highly polluted water body, Devil's Swamp in southeastern Louisiana, has been investigated. Fish from Devil's Swamp bioaccumulated polynuclear aromatic hydrocarbons (PAH), chlorinated hydrocarbon insecticides (CHI), and polychlorinated biphenyls (PCB) in fat tissue, the latter exceeding 7000 ppb. Reference catfish from the University farm, Ben Hur, were virtually devoid of PAH, CHI, and PCB. Liver microsomal enzymes (MFO) from Devil's Swamp fish were markedly induced. The specific content of cytochromes P450 and b5 and the specific activities of NAD(P)H-cytochrome c reductase were two to three times higher than those of Ben Hur fish. Consistent with this induction, a 9000g supernatant from Devil's Swamp but not Ben Hur fish activated 2-aminofluorene and benzo(a)pyrene (BP) to mutagens in the Ames test. BP metabolism by Devil's Swamp fish liver microsomes was inhibited to a greater extent by alpha-naphthoflavone than was BP metabolism by Ben Hur fish microsomes. This finding indicates that the induced activity in the Devil's Swamp fish liver was the result of P450 isozymes characteristic of PAH/PCB induction. Thus, exposure of fish to environmental pollutants can alter MFO leading to enhanced metabolic activation of promutagens to mutagens.

  12. 76 FR 72969 - Proclaiming Certain Lands as Reservation for the Fort Sill Apache Indian Tribe

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ... Indians. FOR FURTHER INFORMATION CONTACT: Ben Burshia, Bureau of Indian Affairs, Division of Real Estate... to residence at such reservation. New Mexico Principal Meridian Luna County, New Mexico That part of... Twenty-four (24) south, Range Six (6) west, N.M.P.M., Luna County, New Mexico, being described as...

  13. 77 FR 49455 - Proclaiming Certain Lands as an Addition to and Becoming a Part of the Laguna Reservation for the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-16

    ... the Pueblo of Laguna Indian Reservation for the Pueblo of Laguna, New Mexico. FOR FURTHER INFORMATION CONTACT: Ben Burshia, Bureau of Indian Affairs, Division of Real Estate Services, MS-4639-MIB, 1849 C... Reservation Cibola County, New Mexico Those certain parcels of land known as Parcels I and II,...

  14. Making the Negev Bloom

    ERIC Educational Resources Information Center

    Harman, Danna

    2007-01-01

    In this article, the author features Ben Gurion University of the Negev, which was established in 1969 in Beersheba, the south's largest city, with a self-proclaimed double mission: to educate students and to help solve the many problems that have plagued the communities that surround it. While it is clear that one university cannot solve the…

  15. Predicting Drug Court Treatment Completion Using the MMPI-2-RF

    ERIC Educational Resources Information Center

    Mattson, Curtis; Powers, Bradley; Halfaker, Dale; Akeson, Steven; Ben-Porath, Yossef

    2012-01-01

    We examined the ability of the Minnesota Multiphasic Personality Inventory-2 Restructured Form (MMPI-2-RF; Ben-Porath & Tellegen, 2008) substantive scales to predict Drug Court treatment completion in a sample of individuals identified as being at risk for failure to complete the program. Higher scores on MMPI-2-RF scales Behavior/Externalizing…

  16. Response Inhibition in Preschoolers at Familial Risk for Attention Deficit Hyperactivity Disorder: A Behavioral and Electrophysiological Stop-Signal Study

    ERIC Educational Resources Information Center

    Berger, Andrea; Alyagon, Uri; Hadaya, Hadas; Atzaba-Poria, Naama; Auerbach, Judith G.

    2013-01-01

    Children participating in the Ben-Gurion Infant Development Study were assessed with a dynamic-tracking version of the stop-signal task at the age of 5 years. The sample consisted of 60 males. Stop-signal reaction time (SSRT) was correlated with concurrent ratings of the child's attention deficit hyperactivity disorder (ADHD) symptoms.…

  17. Yield estimation in commercial cranberry systems using physiological, environmental, and genetic variables

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This study sought to improve the current understanding of yield by measuring the effects of genetic, physiological, and environmental variables on yield. Sixty-six variables representing ‘Stevens’ and ‘Ben Lear’ cultivars were evaluated from samples collected from eight commercial cranberry marshes ...

  18. AN APPROACH TO THE DEVELOPMENT OF MODELS TO QUANTITATIVELY ASSESS THE EFFECTS OF EXPOSURE TO ENVIRONMENTALLY RELEVANT LEVELS OF ENDOCRINE DISRUPTORS

    EPA Science Inventory

    An approach to the development of quantitative models to assess the effects of exposure to environmentally relevant levels of endocrine disruptors on homeostasis in adults.

    Ben-Jonathan N, Cooper RL, Foster P, Hughes CL, Hoyer PB, Klotz D, Kohn M, Lamb DJ, Stancel GM.
    <...

  19. Private Higher Education: The Job Ahead. Volume 9.

    ERIC Educational Resources Information Center

    American Association of Presidents of Independent Colleges and Universities, Rockford, IL.

    Issues pertaining to private higher education are considered in five articles. In "Toward a Philosophy of Higher Education," Ben C. Fisher suggests a need for greater unity of purpose, more attention to producing good citizens, and a sense of the importance of religious values. The maintenance of a strong dual system of education, both at the…

  20. Chronicle of Higher Education. Volume 50, Number 49, August 13, 2004

    ERIC Educational Resources Information Center

    Chronicle of Higher Education, 2004

    2004-01-01

    "Chronicle of Higher Education" presents an abundant source of news and information for college and university faculty members and administrators. This August 13, 2004 issue of "Chronicle of Higher Education" includes the following articles: (1) "Don't Be That Guy" (Ben-Al, Sarah; Sterritt, David); (2) "A Diverse Department" (Baron, Dennis;…

  1. Afro-American Literature Units: The Junior Novel, Drama, Biography; Grades 8, 9, 10.

    ERIC Educational Resources Information Center

    Montgomery County Public Schools, Rockville, MD.

    This course guide for black literature recommends three specific themes for each of three literary genres: (1) the junior novel--Man's Relations to Mankind and to Self in "The Troubled Summer" by Ben Haas (grade 8); (2) drama--Human Relations and Values in "A Raisin in the Sun" by Lorraine Hansberry (grade 9); and (3) biography--Character and…

  2. A Working Ranch with an Effective Medusahead Management Program

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Since 2005, rancher Ben McGough, owner of the Circle Bar Ranch in Mitchell, Oregon, has been working with USDA-ARS rangeland ecologist Roger Sheley to implement EBIPM on the ranch. More than 600 acres were infested with medusahead (Taeniatherum caput-medusae) when they began working together. We de...

  3. A working ranch with an effective medusahead management program

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Since 2005, ranchers Ben and Barbara McGough of the Circle Bar Ranch in Mitchell, OR have been implementing ecologically-based invasive plant management (EBIPM) for extensive infestations of the invasive annual grass, medusahead on their property. This video details the scope of the problem, the im...

  4. Acne

    MedlinePlus

    ... can try different ones to see which helps. Products with benzoyl peroxide (say: BEN-zoil peh - ROK - side) or salicylic (say: sal-uh-SIL - ick) acid in them are usually pretty helpful for treating acne. Benzoyl peroxide kills the bacteria that can lead to acne and it also ...

  5. The Ability of Minnesota Multiphasic Personality Inventory--2 Validity Scales To Detect Fake-Bad Responses in Psychiatric Inpatients.

    ERIC Educational Resources Information Center

    Arbisi, Paul A.; Ben-Porath, Yossef S.

    1998-01-01

    The effectiveness of the Infrequency-Psychopathology Scale (P. Arbisi and Y. Ben-Porath, 1995) in discriminating between groups of patients administered the Minnesota Multiphasic Personality Inventory--2 under honest and fake-bad conditions was studied with 74 patients. Results support use of the scale in detecting malingering in psychiatric…

  6. Evaluating the Latent Structure of the MMPI-2 F(p) Scale in a Forensic Sample: A Taxometric Analysis

    ERIC Educational Resources Information Center

    Strong, David R.; Glassmire, David M.; Frederick, Richard I.; Greene, Roger L.

    2006-01-01

    P. A. Arbisi and Y. S. Ben-Porath (1995) originally proposed that the Infrequency Psychopathology scale, F(p), be used as the final step in an algorithm to determine the validity of a Minnesota Multiphasic Personality Inventory-2 (MMPI-2) protocol. The current study used taxometric procedures to determine the latent structure of F(p) among…

  7. Chronicle of Higher Education. Volume 51, Number 30, April 1, 2005

    ERIC Educational Resources Information Center

    Chronicle of Higher Education, 2005

    2005-01-01

    "Chronicle of Higher Education" presents an abundant source of news and information for college and university faculty members and administrators. This April 1, 2005 issue of "Chronicle of Higher Education" includes the following articles: (1) "Hollywood Profits v. Technological Progress" (Ben-Atar, Doron); (2) "Notes on Metakitsch" (Yaffe,…

  8. Crew of Gemini 10 arrive aboard the recovery ship U.S.S. Guadalcanal

    NASA Technical Reports Server (NTRS)

    1966-01-01

    Crew of Gemini 10 space flight, Astronauts John W. Young (left) and Michael Collins (right), arrive aboard the recovery ship U.S.S. Guadalcanal. Greeting them are Ben James, Senior NASA Public Affairs Officer aboard ship and John C. Stonesifer, Manned Spacecraft Center (MSC) Landing and Recovery Division.

  9. Educational Justice, Epistemic Justice, and Leveling Down

    ERIC Educational Resources Information Center

    Kotzee, Ben

    2013-01-01

    Harry Brighouse and Adam Swift argue that education is a positional good; this, they hold, implies that there is a qualified case for leveling down educational provision. In this essay, Ben Kotzee discusses Brighouse and Swift's argument for leveling down. He holds that the argument fails in its own terms and that, in presenting the problem…

  10. Freedom Road: Colonial Life

    ERIC Educational Resources Information Center

    Auerbach, Barbara

    2010-01-01

    While historical fiction by Jean Fritz as well as titles like Robert Lawson's "Ben and Me" (1939) or "Mr. Revere and I" (1954) and Esther Forbes's "Johnny Tremain" (1943) are widely known classics that bring this period to life, recent years have yielded a wealth of new offerings--many of which are accessible picture books or read-alouds. These…

  11. 1975--Looking Ahead

    ERIC Educational Resources Information Center

    Training and Development Journal, 1975

    1975-01-01

    Several prominent figures in the training and development/human resources profession offer their appraisals of the challenges facing practitioners in 1975. Included are Joe Batten, Martin Broadwell, Kate Kirkham, Malcolm Knowles, Tom Jaap, Gordon Lippitt, George Ordione, and Ben Treoge. (MW)

  12. Exemplary World Wide Web Resources. Pull-out Feature 3.

    ERIC Educational Resources Information Center

    Helms, Ronald G.

    1997-01-01

    Offers an abundance of World Wide Web resources for K-12 educators. Briefly describes interesting web sites, including the "K-12 History on the Internet Resource Guide" and sites by National Geographic, the Smithsonian Institute, and Ben and Jerry's. Discusses personal web pages including the author's own. (MJP)

  13. Science Fiction: Today and Tomorrow.

    ERIC Educational Resources Information Center

    Bretnor, Reginald, Ed.

    A critical symposium on science fiction, this book features essays (by Ben Bova, Frederik Pohl, George Zebrowski, Frank Herbert, Theodore Sturgeon, Alan E. Nourse, Thomas N. Scortia, Reginald Bretnor, James Gunn, Alexei and Cory Panshin, Poul Anderson, Hal Clement, Anne McCaffrey, Gordon R. Dickson, and Jack Williamson) dealing with such subjects…

  14. Indigenous Knowledge and Science in a Globalized Age

    ERIC Educational Resources Information Center

    Regmi, Jagadish; Fleming, Michelle

    2012-01-01

    This forum explores and expands on Ben-Zvi Assaraf, Eshach, Orion, and Alamour's article titled "Cultural Differences and Students' Spontaneous Models of the Water Cycle: A Case Study of Jewish and Bedouin Children in Israel" by examining how indigenous knowledge is appropriated in science classrooms; how students from indigenous students'…

  15. Rethinking Historical and Cultural Source of Spontaneous Mental Models of Water Cycle: In the Perspective of South Korea

    ERIC Educational Resources Information Center

    Nam, Younkyeong

    2012-01-01

    This review explores Ben-Zvi Assaraf, Eshach, Orion, and Alamour's paper titled "Cultural Differences and Students' Spontaneous Models of the Water Cycle: A Case Study of Jewish and Bedouin Children in Israel" by examining how the authors use the concept of spontaneous mental models to explain cultural knowledge source of Bedouin children's mental…

  16. Holocaust Education in Jewish Schools in Israel: Goals, Dilemmas, Challenges

    ERIC Educational Resources Information Center

    Gross, Zehavit

    2010-01-01

    Research has shown the Holocaust to be the primary component of Jewish identity (Farago in Yahadut Zmanenu 5:259-285, 1989; Gross in Influence of the trip to Poland within the framework of the Ministry of Education on the working through of the Holocaust. Unpublished M.A. thesis, Ben-Gurion University, Beer Sheva, 2000; "Herman in Jewish identity:…

  17. Expanding Excellence: Teachers Cross District Lines to Learn with Peers

    ERIC Educational Resources Information Center

    Owens, Ben; Strahan, David

    2016-01-01

    This article provides a vignette which demonstrates some of the outcomes that occur when teachers collaborate across school district lines. The project began as an idea from Ben Owens, a 2014 Hope Street Group National Teacher Fellow. The basic notion was that good teaching doesn't happen in isolation. As someone who came into teaching after a…

  18. Frost Bite: A Dramatic Tale of Research in Aesthetic Education

    ERIC Educational Resources Information Center

    Hirsch, Miriam

    2008-01-01

    This article follows the author's research on the integration of an aesthetic arts initiative in a private elementary school with an established traditional arts program. The narrative describes the sequence of events, interpersonal interactions, and learning experiences in the format of a full-length dramatic performance. Informed by Ben Peretz's…

  19. Books Day by Day: Anniversaries, Anecdotes, and Activities.

    ERIC Educational Resources Information Center

    Ohanian, Susan

    Celebrating centuries of the written word--from the works of Confucius, Shakespeare, and Ben Franklin to the adventures of Nancy Drew and Harry Potter--this book offers a literary smorgasbord of milestones, anecdotes, and quotes, along with smart, fun, practical activities for exploring and enjoying a wide range of literature. More than a calendar…

  20. Education and "Thick" Epistemology

    ERIC Educational Resources Information Center

    Kotzee, Ben

    2011-01-01

    In this essay Ben Kotzee addresses the implications of Bernard Williams's distinction between "thick" and "thin" concepts in ethics for epistemology and for education. Kotzee holds that, as in the case of ethics, one may distinguish between "thick" and "thin" concepts of epistemology and, further, that this distinction points to the importance of…

  1. The Construction of a Managerial Education Discourse and the Involvement of Philanthropic Entrepreneurs: The Case of Israel

    ERIC Educational Resources Information Center

    Resnik, Julia

    2011-01-01

    Similar to many other countries, an educational reform anchored in a managerial discourse was proposed in Israel in 2004 by the Dovrat Committee, encouraged by the "inter-state education gap" social problem that economist Dan Ben-David formulated on the basis of international examinations, such as PISA and TIMMS. Through a neo-Weberian approach…

  2. Effect of harvest timing on leaf production and yield of diterpene glycosides in Stevia rebaudiana Bert: a specialty perennial crop for Mississippi

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Stevia rebaundiana (Bertoni), a perennial shrub of the Asteraceae, is one of the most important sources of non-caloric natural sweeteners. Stevia’s plant extracts and glycosides have been used for several years in Paraguay and Brazil. Several studies suggest that Stevia and its glycosides exert ben...

  3. Generation of broadband electrostatic waves in Earth's magnetotail.

    PubMed

    Grabbe, C

    2000-04-17

    The theory that broad-band electrostatic waves (BEN) in Earth's magnetotail are trapped-electron ("BGK") modes is reexamined. Electron/ion beams analyzed for a realistic magnetized-plasma source model with kappa distributions are found to drive an unstable spectrum of broad angular range over several orders of magnitude in f, up to (0.1-0.2)f(pe). Analysis indicates that trapping essential for the BGK paradigm is good only at the highest f, whereas most of the spectrum has minimal trapping and can be driven by electron/ion beam instabilities. A new model is proposed in which trapped-electron modes exist only at the highest f band, whereas electron/ion beam instabilities drive the bulk of the broad-band spectrum below that. BEN wave data from ISEE-1 and ISEE-3 show large angles of propagation with respect to the magnetic field for ff(ce) is observed only in a narrow angular range around the magnetic field and may be BGK modes. This predicts that the BEN solitary waves in the source region are not in BEN well into the lobe. PMID:11019159

  4. Revisiting Curriculum Potential

    ERIC Educational Resources Information Center

    Deng, Zongyi

    2011-01-01

    This article analyzes the notion of curriculum potential by revisiting the ideas of Miriam Ben-Peretz and Joseph Schwab. Invoking the German "Didaktik" tradition and by way of a curriculum-making framework, the paper argues that interpreting curriculum materials for curriculum potential requires a careful analysis and unpacking of the meanings and…

  5. MediBook: Combining Semantic Networks with Metadata for Learning Resources To Build a Web Based Learning System.

    ERIC Educational Resources Information Center

    Steinacker, Achim; Faatz, Andreas; Seeberg, Cornelia; Rimac, Ivica; Hormann, Stefan; El Saddik, Abdulmotaleb; Steinmetz, Ralf

    This paper gives an overview of MediBook, a joint project of the Medical Department of the University GieBen (Germany) and the Department of Electrical Engineering and Information Technology at Darmstadt University of Technology (Germany) funded by the Hessian Ministry for Science and Arts (HMWK). The basis of MediBook is a formal representation…

  6. The Introduction of Religious Charter Schools: A Cultural Movement in the Private School Sector

    ERIC Educational Resources Information Center

    Bailey, Marcia J. Harr; Cooper, Bruce S.

    2009-01-01

    Charter schools are opening, and religious associations are also sponsoring these schools since religious groups find private school tuitions to be high and prohibitive. This study includes studies of Tarek ibn Ziyad Academy, a Minnesota Arabic charter school (Blaine and Inver Grove Heights, MN); Ben Gamla Charter School, a Florida English-Hebrew…

  7. 5. East and north (rear) elevations of the horse pasture ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. East and north (rear) elevations of the horse pasture store, looking southwest; the store's two outbuildings can ben seen at the right of the view - Horsepasture Store, U.S. Route 58 & State Route 687, Horse Pasture, Henry County, VA

  8. 76 FR 12408 - Notice of Intent to Rule on Request To Release Airport Property at Ellington Field Airport...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-07

    ... Ellington Field Airport, Houston, Texas AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice..., Aviation Director, at the following address: Mr. Mario C. Diaz, Aviation Director, Houston Airport System, 16930 John F. Kennedy Blvd., Houston, Texas 77032. FOR FURTHER INFORMATION CONTACT: Mr. Ben...

  9. Due Process Hearing Case Study

    ERIC Educational Resources Information Center

    Bateman, David F.

    2008-01-01

    Ben is a 16-year-old student who resides with his family in an unnamed School District. He is eligible for special education by reason of specific learning disability and ADHD. His parents requested a due process hearing, alleging that the District failed to provide him with a free appropriate public education (FAPE) and requesting reimbursement…

  10. Value Added Processing of Aflatoxin Contaminated Peanut Meal: Aflatoxin Sequestration During Protein Extraction

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The efficacy of a bentonite clay, Astra-Ben 20A (AB20A), to sequester aflatoxin from contaminated (~110 ppb) peanut meal during protein extraction was studied. Aqueous peanut meal dispersions (10% w/w) were prepared varying pH, temperature, enzymatic hydrolysis conditions, and concentrations of AB2...

  11. The New Campus, 1982. Volume 35.

    ERIC Educational Resources Information Center

    Hackler, George, Ed.

    1982-01-01

    Ten articles on continuing professional education are presented. Titles and authors are as follows: "Merging Continuing Education and Inservice Teacher Education: A Concept Worth Exploring" (Alvah M. Kilgore); "Ablative Absolute Continuing Education, Ignorance Flees" (Ben J. Wiens); "Humanize! Individualize! Personalize! Through Contracting" (Carl…

  12. The Relationship between Sensory Sensitivity and Autistic Traits in the General Population

    ERIC Educational Resources Information Center

    Robertson, Ashley E.; Simmons, David R.

    2013-01-01

    Individuals with Autism Spectrum Disorders (ASDs) tend to have sensory processing difficulties (Baranek et al. in J Child Psychol Psychiatry 47:591-601, 2006). These difficulties include over- and under-responsiveness to sensory stimuli, and problems modulating sensory input (Ben-Sasson et al. in J Autism Dev Disorders 39:1-11, 2009). As those…

  13. Cholesterol-lowering activity of soy-derived glyceollins in the golden Syrian hamster model

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Hypercholesterolemia is one of the major factors contributing to the risk of cardiovascular disease (CVD), which is the leading cause of death in the developed countries. Consumption of soy foods has been recognized to lower the risk of CVD, and phytochemicals in soy may contribute to the health ben...

  14. 7 CFR 1944.450 - OMB control number.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 13 2014-01-01 2013-01-01 true OMB control number. 1944.450 Section 1944.450... number. The reporting and recordkeeping requirements contained in this regulation have ben approved by the Office of Management and Budget and have been assigned OMB control number 0575-0043....

  15. Coming to a hospital near you: mass spectrometry imaging

    SciTech Connect

    Bowen, Ben

    2013-10-31

    Berkeley Lab's Ben Bowen discusses "Coming to a hospital near you: mass spectrometry imaging" in this Oct. 28, 2013 talk, which is part of a Science at the Theater event entitled Eight Big Ideas. Go here to watch the entire event with all 8 speakers.

  16. Potential functional variants associated with age at puberty in a validation population of swine

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Puberty in pigs is defined as age at first estrus and gilts that have an earlier age at puberty are more likely to have greater sow lifetime productivity. Because age at puberty is predictive for sow longevity and lifetime productivity, but not routinely measured in commercial herds, it would be ben...

  17. 300 Junior Novel Anticipation Guides

    ERIC Educational Resources Information Center

    Polette, Nancy

    2006-01-01

    In this book, the author has created reproducible anticipation guides to 300 popular junior novels (grades 4-8) ranging from classics like Ben and Me and Cricket in Times Square to the current award winner, Kira, Kira. The book consists of 300 reproducible sets of open ended values questions to pique the interest of readers. Librarians and…

  18. The ABC's of Professionalism

    ERIC Educational Resources Information Center

    Kramer, Pamela A.

    2003-01-01

    Every teacher must develop the characteristics of a professional and model professionalism everyday. In fact, among the standards of the National Council for Accreditation of Teacher Education (NCATE) is a requirement that teacher candidates demonstrate specific dispositions of professionals (NCATE 2001). Bridges (in Ben-Peretz 2001, 50) advised…

  19. Walbridge School: At Walbridge School in Madison, WI, One Size Does Not Fit All

    ERIC Educational Resources Information Center

    Perreth, Katherine

    2009-01-01

    In this article, the author talks about Walbridge School, a small school in Madison, Wisconsin that brings hope to students with disabilities. The author shares how her eldest son, Ben, who has experienced cognitive impairment, specifically language processing, has improved his reading and writing skills. The small school, with its teacher/pupil…

  20. Psychometric Properties of the MMPI-2-RF Somatic Complaints (RC1) Scale

    ERIC Educational Resources Information Center

    Thomas, Michael L.; Locke, Dona E. C.

    2010-01-01

    The MMPI-2 Restructured Form (MMPI-2-RF; Tellegen & Ben-Porath, 2008) was designed to be psychometrically superior to its MMPI-2 counterpart. However, the test has yet to be extensively evaluated in diverse clinical settings. The purpose of this study was to examine the psychometric properties of the MMPI-2-RF Somatic Complaints (RC1) scale in a…

  1. A current disruption mechanism in the neutral sheet for triggering substorm expansions

    NASA Technical Reports Server (NTRS)

    Lui, A. T. Y.; Mankofsky, A.; Chang, C.-L.; Papadopoulos, K.; Wu, C. S.

    1989-01-01

    Two main areas were addressed in support of an effort to understand mechanism responsible for the broadband electrostatic noise (BEN) observed in the magnetotail. The first area concerns the generation of BEN in the boundary layer region of the magnetotail whereas the second area concerns the occassional presence of BEN in the neutral sheet region. For the generation of BEN in the boundary layer region, a hybrid simulation code was developed to perform reliable longtime, quiet, highly resolved simulations of field aligned electron and ion beam flow. The result of the simulation shows that broadband emissions cannot be generated by beam-plasma instability if realistic values of the ion beam parameters are used. The waves generated from beam-plasma instability are highly discrete and are of high frequencies. For the plasma sheet boundary layer condition, the wave frequencies are in the kHz range, which is incompatible with the observation that the peak power in BEN occur in the 10's of Hz range. It was found that the BEN characteristics are more consistent with lower hybrid drift instability. For the occasional presence of BEN in the neutral sheet region, a linear analysis of the kinetic cross-field streaming instability appropriate to the neutral sheet condition just prior to onset of substorm expansion was performed. By solving numerically the dispersion relation, it was found that the instability has a growth time comparable to the onset time scale of substorm onset. The excited waves have a mixed polarization in the lower hybrid frequency range. The imposed drift driving the instability corresponds to unmagnetized ions undergoing current sheet acceleration in the presence of a cross-tail electric field. The required electric field strength is in the 10 mV/m range which is well within the observed electric field values detected in the neutral sheet during substorms. This finding can potentially account for the disruption of cross-tail current and its diversion to

  2. Essential oil from black currant buds as chemotaxonomy marker and antimicrobial agent.

    PubMed

    Ethorđević, Boban S; Pljevljakušić, Ðorđević S; Savikin, Katarina P; Stević, Tatjana R; Bigović, Dubravka J

    2014-08-01

    Dormant buds are recognized as valuable side product of the blackcurrant cultivation. Four blackcurrant varieties cultivated in Serbia, i.e., Ben Sarek, Ometa, Ben Lomond, and Ben Nevis, were evaluated for the content, chemical composition, and antimicrobial activity of their bud essential oils. The oil yields of buds harvested during two different growth periods ranged from 1.2-2.0%, and the variety Ometa had the highest yield among the tested varieties. GC-FID and GC/MS analysis of the oils allowed the identification of eight main components, i.e., α-pinene (1.6-5.4%), sabinene (1.9-38.4%), δ-car-3-ene (13.0-50.7%), β-phellandrene (2.9-18.0%), terpinolene (6.6-11.9%), terpinen-4-ol (0.9-6.6%), β-caryophyllene (3.8-10.4%), and α-humulene (0.2-4.1%). In addition, the similarity degree of the essential-oil compositions of buds harvested from the upper and lower parts of the shrubs was investigated by hierarchical clustering. All essential oils originating from the same genotype were grouped in the same cluster, indicating the reliability of essential oils as chemotaxonomic markers. For more detailed chemotaxonomic investigations, the three compounds with the greatest variance were chosen, i.e., sabinene, δ-car-3-ene, and β-phellandrene, which proved to be efficient for the variety distinction. Factor analysis showed that the essential-oil composition as chemotaxonomic marker in blackcurrants was more reliable for variety Ben Sarek than for variety Ben Nevis. Moreover, it was demonstrated that the essential oils had very strong inhibitory activity against all tested microorganisms. Fungi were more sensitive than bacteria; indeed their growth was completely inhibited at much lower concentrations. In comparison to commercial antibiotics, significantly lower concentrations of the oils were necessary for the complete inhibition of fungal growth. PMID:25146766

  3. A LATE BRITTLE COMPONENT OF MOTION WITHIN THE DUCTILE EASTERN SIERRA CREST SHEAR ZONE (ESCSZ) ALONG THE EASTERN BOUNDARY OF THE TOLUMNE BATHOLITH IN THE SADDLEBAG LAKE, CA AREA. WHITESIDES, Andrew1, ENRIQUEZ, Marcus2 , HARDY, Jill1 , EHRET, Philip1, IANNONE, Monika1, CULBERT, Kristan1 GROSS, Ben3, LODEWYK, Jessica3, CAO, Wenrong1 , ZHANG, Tao1, MEMETI, Valbone3, PATERSON, Scott1 SCHMIDT, Keegan4. (1) Department of Earth Sciences, University of Southern California, Los Angeles, CA 90089-0740, awhitesi@usc.edu , (2) Department of Geological Sciences, Cal State L.A., 5151 State University Drive, Los Angeles, CA 90032, (3) Department of Earth and Planetary Sciences, Washington University, Campus Box 1169, 1 Brookings Dr, Saint Louis, MO, 63130, (4) Division of Natural Science and Mathematics, Lewis-Clark State College, 500 8th Ave., Lewiston, ID 83501

    NASA Astrophysics Data System (ADS)

    Whitesides, A. S.; Enriquez, M.; Hardy, J.; Ehret, P.; Iannone, M.; Culbert, K. N.; Gross, M. B.; Lodewyk, J.; Cao, W.; Zhang, T.; Memeti, V.; Paterson, S. R.; Schmidt, K. L.

    2009-12-01

    During mapping (by the Undergraduate Team Research program, University of Southern California) in the Saddlebag Lake pendant just along the eastern margin of the Tuolumne batholith we have discovered a brittle slip component in the ESCSZ that juxtaposes largely metasedimentary and metavolcanic rock packages. The metasedimentary package is dominated by bedded sandstones and siltstones and local conglomerates whereas the metavolcanics show a large range of volcanic and volcaniclastic units. All of the units dip steeply and have an average N-NW strike. Dextral oblique ductile shear is distributed in domains in both rock packages with varying width from ~2 km in the South to ~1 km in the North. Shear sense in planes at high angles to a steep to SW plunging mineral lineation include S-C structures, shear bands, asymmetrical folding, sigma and delta clasts, and asymmetrical boudins. Partitioning of shear is common with the metarhyolites and metasediments showing higher non-coaxial strain than in the metaandesite and metadacite units. Map-scale “z-shaped” asymmetrical folds within the shear zone are also consistent with dextral shearing. Folded and sheared dikes of the 88-85 Ma Cathedral Peak phase of the Tuolumne batholith are common in the shear zone. A newly discovered brittle slip surface with breccias, gouge, and local pseudotachylite and large quartz veins was also mapped in the center of the ductile shear zone typically along the contact between the western metasedimentary and eastern metavolcanics (often a metarhyolite at the contact) on the east. Local slickenlines, steps, and offset dikes indicate that the brittle fault also had oblique dextral movement, similar to the ductile shear zone. In the mapped area no dikes originating from the TB cross the brittle fault and some are terminated at the brittle fault surface We interpret these observations to indicate northward displacement of the metasedimentary package by first ductile then brittle faulting during cooling and possibly uplift of this region with the youngest motion post 82 Ma.

  4. Earthquake nucleation mechanisms and periodic loading: Models, Experiments, and Observations

    NASA Astrophysics Data System (ADS)

    Dahmen, K.; Brinkman, B.; Tsekenis, G.; Ben-Zion, Y.; Uhl, J.

    2010-12-01

    The project has two main goals: (a) Improve the understanding of how earthquakes are nucleated ¬ with specific focus on seismic response to periodic stresses (such as tidal or seasonal variations) (b) Use the results of (a) to infer on the possible existence of precursory activity before large earthquakes. A number of mechanisms have been proposed for the nucleation of earthquakes, including frictional nucleation (Dieterich 1987) and fracture (Lockner 1999, Beeler 2003). We study the relation between the observed rates of triggered seismicity, the period and amplitude of cyclic loadings and whether the observed seismic activity in response to periodic stresses can be used to identify the correct nucleation mechanism (or combination of mechanisms). A generalized version of the Ben-Zion and Rice model for disordered fault zones and results from related recent studies on dislocation dynamics and magnetization avalanches in slowly magnetized materials are used in the analysis (Ben-Zion et al. 2010; Dahmen et al. 2009). The analysis makes predictions for the statistics of macroscopic failure events of sheared materials in the presence of added cyclic loading, as a function of the period, amplitude, and noise in the system. The employed tools include analytical methods from statistical physics, the theory of phase transitions, and numerical simulations. The results will be compared to laboratory experiments and observations. References: Beeler, N.M., D.A. Lockner (2003). Why earthquakes correlate weakly with the solid Earth tides: effects of periodic stress on the rate and probability of earthquake occurrence. J. Geophys. Res.-Solid Earth 108, 2391-2407. Ben-Zion, Y. (2008). Collective Behavior of Earthquakes and Faults: Continuum-Discrete Transitions, Evolutionary Changes and Corresponding Dynamic Regimes, Rev. Geophysics, 46, RG4006, doi:10.1029/2008RG000260. Ben-Zion, Y., Dahmen, K. A. and J. T. Uhl (2010). A unifying phase diagram for the dynamics of sheared solids

  5. Big Bang Day : The Great Big Particle Adventure - 1. Atom

    SciTech Connect

    2009-10-08

    In this series, comedian and physicist Ben Miller asks the CERN scientists what they hope to find. The notion of atoms dates back to Greek philosophers who sought a natural mechanical explanation of the Universe, as opposed to a divine one. The existence what we call chemical atoms, the constituents of all we see around us, wasn't proved until a hundred years ago, but almost simultaneously it was realised these weren't the indivisible constituents the Greeks envisaged. Much of the story of physics since then has been the ever-deeper probing of matter until, at the end of the 20th century, a complete list of fundamental ingredients had been identified, apart from one, the much discussed Higgs particle. In this programme, Ben finds out why this last particle is so pivotal, not just to atomic theory, but to our very existence - and how hopeful the scientists are of proving its existence.

  6. Formation of molecules in an expanding Bose-Einstein condensate

    NASA Astrophysics Data System (ADS)

    Yurovsky, Vladimir; Ben-Reuven, Abraham

    2004-05-01

    A mean field theory [1] is extended to an inhomogeneous case of expanding hybrid atom-molecule Bose-Einstein condensates. This theory is applied to the recent MPI experiments [2] on ^87Rb demonstrating the formation of ultracold molecules due to Feshbach resonance. The subsequent dissociation of the molecules is treated using a non-mean-field parametric approximation [3]. The latter method is also used in determining optimal conditions for the formation of molecular BEC. [1] V. A. Yurovsky, A. Ben-Reuven, P. S. Julienne and C. J. Williams, Phys. Rev. A 60, R765 (1999); Phys. Rev. A 62, 043605 (2000). [2] S. Dürr, T. Volz, A. Marte, and G. Rempe, Phys. Rev. Lett. 92, 020406 (2004). [3] V. A. Yurovsky and A. Ben-Reuven, Phys. Rev. A 67, 043611 (2003).

  7. Computer determination of peptide conformations in water: different roads to structure.

    PubMed Central

    Simmerling, C L; Elber, R

    1995-01-01

    Fragments of proteins (short peptides) that "fold" suggest a mechanism of how complete conformational search in protein folding is avoided. We used a computational method to determine structures of two foldable peptides in explicit water: RVEW and CSVTC. The optimization starts from random structures and no experimental constraints are used. In agreement with NMR data, the simulations find a hydrophobic pair (Val/Trp) in REVW. The structure of CSVTC is induced by a surface water that bridges two amide hydrogens, a drive to structure hypothesized by Ben-Naim [Ben-Naim, A. (1990) J. Chem. Phys. 93, 8196-8210] that is largely ignored in studies of folding. Tendency to structure in short peptide chains suggests a mechanism for the formation of short-range nucleation sites in protein folding. Images Fig. 2 Fig. 3 PMID:7724538

  8. First Paleomagnetic Map of the Easternmost Mediterranean Derived from Combined Geophysical-Geological Analysis

    NASA Astrophysics Data System (ADS)

    Eppelbaum, Lev; Katz, Youri

    2014-05-01

    he easternmost Mediterranean is a tectonically complex region evolving in the long term and located in the midst of the progressive Afro-Eurasian collision (e.g., Ben-Avraham, 1978; Khain, 1984). Both rift-oceanic systems and terrane belts are known to have been formed in this collision zone (Stampfli et al., 2013). Despite years of investigation, the geological-geophysical structure of the easternmost Mediterranean is not completely known. The formation of its modern complex structure is associated with the evolution of the Neotethys Ocean and its margins (e.g., Ben-Avraham and Ginzburg, 1990; Robertson et al., 1991; Ben-Avraham et al., 2002). The easternmost Mediterranean was formed during the initial phase of the Neotethys in the Early and Late Permian (Golonka and Ford, 2000; Stampfli et al., 2013). At present this block of the ocean crust situated in the northern part of the Sinai plate (Ben-Avraham, 1978; Eppelbaum et al., 2012, 2014) is object of our investigation. The easternmost Mediterranean region has attracted increasing attention in connection with the recent discoveries of significant hydrocarbon deposits in this region (e.g., Montadert et al., 2010; Schenk et al., 2010; Eppelbaum et al., 2012). For example, Schenk et al. (2010) consider that more than 4 trillion m3 of recoverable gas is available in the Levant Basin (which located in the central part of the easternmost Mediterranean). Currently seismic prospecting is the main tool used in hydrocarbon deposit discovery. However, even sophisticated seismic data analysis (e.g., Hall et al., 2005; Roberts and Peace, 2007; Gardosh et al., 2010; Marlow et al., 2011; Lazar et al., 2012), fails to identify the full complex structural-tectonic mosaic of this region, and more importantly, is unable to clarify its baffling complex tectonic evolution. This highlights the need for combined analysis of geophysical data associated with the paleomagnetic and paleobiogeographic conditions that can yield deep

  9. Trojan Horse Method: recent results in nuclear astrophysics

    NASA Astrophysics Data System (ADS)

    Spitaleri, C.; Lamia, L.; Gimenez Del Santo, M.; Burjan, V.; Carlin, N.; Li, Chengbo; Cherubini, S.; Crucilla, V.; Gulino, M.; Hons, Z.; Kroha, V.; Irgaziev, B.; La Cognata, M.; Mrazek, J.; Mukhamedzhanov, M.; Munhoz, M. G.; Palmerini, S.; Pizzone, R. G.; Puglia, M. R.; Rapisarda, G. G.; Romano, S.; Sergi, L.; Zhou, Shu-Hua; Somorjai, E.; Souza, F. A.; Tabacaru, G.; Szanto de Toledo, A.; Tumino, A.; Wen, Qungang; Wakabayashi, Y.; Yamaguchi, H.

    2015-07-01

    The accurate knowledge of thermonuclear reaction rates is important in understanding the energy generation, the neutrinos luminosity and the synthesis of elements in stars. The physical conditions under which the majority of astrophysical reactions proceed in stellar environments make it difficult or impossible to measure them under the same conditions in the laboratory. That is why different indirect techniques are being used along with direct measurements. The Trojan Horse Method (THM) is introduced as an independent technique to obtain the bare nucleus astrophysical S(E)-factor. As examples the results of recent the application of THM to the 2H(11B, σ08Be)n and 2H(10B, σ07Be)n reactions are presented.

  10. [Huang Yizhou's study on Nei jing (Inner Canon)].

    PubMed

    Hu, Benxiang; Huang, Youmei; Yu, Chengfen

    2002-01-01

    Being a great classical scholar of the late Qing dynasty, Huang Yizhou collated Nei jing (Inner Canon) by textual criticism. But most of his works were missing. By reviewing historical documents and literature, it has been found that his collated books include Huang di nei jing su wen jiao ben (Collated Edition of Huangdi's Inner Canon Plain Questions), Huang di nei jing su wen chong jiao zheng (Recollated Huangdi's Inner Canon Plain Questions), Nei jing zhen ci (Acupuncture in Inner Canon), Huang di nei jing jiu juan ji zhu (Variorum of Nine Volumes of Huangdi's Inner Canon), Huang di nei jing ming tang (Acupuncture Chart of Huangdi's Inner Canon), and Jiu chao tai su jiao ben (Old Extremely Plain Question Recension). Many of his disciples became famous scholars in the Republican period. PMID:12015056

  11. Teaching children generalized imitation skills: a case report.

    PubMed

    Brown, Freddy Jackson; Peace, Natalie; Parsons, Rachel

    2009-03-01

    Generalized imitation plays an important role in the acquisition of new skills, in particular language and communication. In this case report a multiple exemplar training procedure, with an errorless learning phase, was used to teach Ben, a 13-year-old child with severe intellectual disabilities, to imitate behaviours modelled by an adult instructor. After exposure to seven multiple exemplars, Ben learned to imitate novel actions to criterion (i.e. generalized imitation). These skills were maintained at 90 percent at 6 week and 18 week follow-up. In line with earlier research, this article provides some further support for the finding that multiple exemplar training can facilitate the reliable emergence of generalized imitation skills. Topographically similar behaviours during the learning phase can be difficult to discriminate and hence can slow the learning process. Future research could explore how generalized imitation supports the development of basic communication and activity skills. PMID:19332505

  12. Globularity and language-readiness: generating new predictions by expanding the set of genes of interest

    PubMed Central

    Boeckx, Cedric; Benítez-Burraco, Antonio

    2014-01-01

    This study builds on the hypothesis put forth in Boeckx and Benítez-Burraco (2014), according to which the developmental changes expressed at the levels of brain morphology and neural connectivity that resulted in a more globular braincase in our species were crucial to understand the origins of our language-ready brain. Specifically, this paper explores the links between two well-known ‘language-related’ genes like FOXP2 and ROBO1 implicated in vocal learning and the initial set of genes of interest put forth in Boeckx and Benítez-Burraco (2014), with RUNX2 as focal point. Relying on the existing literature, we uncover potential molecular links that could be of interest to future experimental inquiries into the biological foundations of language and the testing of our initial hypothesis. Our discussion could also be relevant for clinical linguistics and for the interpretation of results from paleogenomics. PMID:25505436

  13. Big Bang Day : The Great Big Particle Adventure - 1. Atom

    ScienceCinema

    None

    2011-04-25

    In this series, comedian and physicist Ben Miller asks the CERN scientists what they hope to find. The notion of atoms dates back to Greek philosophers who sought a natural mechanical explanation of the Universe, as opposed to a divine one. The existence what we call chemical atoms, the constituents of all we see around us, wasn't proved until a hundred years ago, but almost simultaneously it was realised these weren't the indivisible constituents the Greeks envisaged. Much of the story of physics since then has been the ever-deeper probing of matter until, at the end of the 20th century, a complete list of fundamental ingredients had been identified, apart from one, the much discussed Higgs particle. In this programme, Ben finds out why this last particle is so pivotal, not just to atomic theory, but to our very existence - and how hopeful the scientists are of proving its existence.

  14. Some classes of renormalizable tensor models

    NASA Astrophysics Data System (ADS)

    Geloun, Joseph Ben; Livine, Etera R.

    2013-08-01

    We identify new families of renormalizable tensor models from anterior renormalizable tensor models via a mapping capable of reducing or increasing the rank of the theory without having an effect on the renormalizability property. Mainly, a version of the rank 3 tensor model as defined by Ben Geloun and Samary [Ann. Henri Poincare 14, 1599 (2013); e-print arXiv:1201.0176 [hep-th

  15. The Novel Small Molecule Inhibitor, OSU-T315, Suppresses Vestibular Schwannoma and Meningioma Growth by Inhibiting PDK2 Function in the AKT Pathway Activation

    PubMed Central

    Mercado-Pimentel, ME; Igarashi, S; Dunn, AM; Behbahani, M; Miller, C; Read, CM; Jacob, A

    2016-01-01

    Activation of PKB/AKT signaling, which requires PDK1 and PDK2 function, drives Vestibular Schwannoma (VS) and meningioma growth. PDK2 function is defined as a molecule that phosphorylates AKT-Ser473. Integrin-Linked Kinase (ILK) functions as PDK2 in PKB/AKT activation in many cancers; therefore, we hypothesized that OSU-T315, a small molecule ILK inhibitor, will inhibit the ILK-PDK2 function in PKB/AKT signaling activation in VS and meningioma cell growth. OSU-T315 decreased cell viability at IC50 < 2μM in VS (HEI193) and meningioma (Ben-Men-1) cell lines, in primary cells at < 3.5μM, while in normal primary Schwann cells at 7.1μM. OSU-T315 inhibits AKT signaling by decreasing phosphorylation at AKT-Ser473, AKT-Thr308, ILK-Ser246 and ILK-Thr173. In addition, OSU-T315 affected the phosphorylation or expression levels of AKT downstream proliferation effectors as well as autophagy markers. Flow cytometry shows that OSU-T315 increased the percentage of cells arrested at G2/M for both, HEI193 (39.99%) and Ben-Men-1 (26.96%) cells, compared to controls (21.54%, 8.47%). Two hours of OSU-T315 treatment increased cell death in both cell lines (34.3%, 9.1%) versus untreated (12.1%, 8.1%). Though longer exposure increased cell death in Ben-Men-1, TUNEL assays showed that OSU-T315 does not induce apoptosis. OSU-T315 was primarily cytotoxic for HEI193 and Ben-Men-1 inducing a dysregulated autophagy. Our studies suggest that OSU-T315 has translational potential as a chemotherapeutic agent against VS and meningioma.

  16. Management of mycoses in neutropenic patients: a brief history, 1960–2008

    PubMed Central

    Bennett, John E.

    2009-01-01

    The career that this symposium honours, that of Ben E. de Pauw, MD, PhD, could be said to have begun in 1970 upon his graduation from the University of Amsterdam. However, it was his move to Nijmegen in 1975 to finish his PhD studies that really began the career in which he forged expertise in haematology, oncology, immunology and infectious diseases into one spectacular career that resulted in more than 200 publications. PMID:19372177

  17. Nouvelles données paléoenvironnementales pour le Quaternaire récent en Tunisie centrale (bassin de Maknassy)

    NASA Astrophysics Data System (ADS)

    Ouda, Bouchra; Zouari, Kamel; Ouezdou, Hedi Ben; Chkir, Najiba; Causse, Christiane

    1998-06-01

    Sedimentary deposits outcropping on the Wadi Leben and Wadi Ben Sellam banks in the Maknassy Basin (central Tunisia) have registered paleoclimatic variations, and particularly humid episodes, already known for Upper Pleistocene and Holocene, in present hyperarid areas of northern Sahara. A pluridisciplinary study, including prehistory, sedimentology, mineralogy, ecology and radiochronology ( 14C, uranium-thorium [U-Th]), improves the comprehension of paleoenvironmental interpretations and makes it possible to precisely determine the chronological framework of humid episodes during the Upper Quaternary in Tunisia.

  18. [Intensive care and legislation].

    PubMed

    Ehlers, Alexander P F; Moroder, Anke

    2016-04-01

    Der Artikel beschäftigt sich zunächst mit einem Überblick über den Rechtsrahmen von ärztlicher Behandlung am Lebensende und sodann mit den derzeit gültigen Maßstäben für Sterbehilfe. Dabei wird das neue Gesetz zur Strafbarkeit der geschäftsmäßigen Förderung der Selbsttötung berücksichtigt. PMID:27031200

  19. Different Representations of Physics or Hail Poetry! — Thou heaven-born maid, thou gildest e'en the physics teacher's trade! (stolen from W. S. Gilbert)

    NASA Astrophysics Data System (ADS)

    Morse, Robert

    2006-12-01

    Robert Morse, physics teacher at St. Albans School in Washington, D.C., has taught physics in public and private schools for 37 years. His website on Ben Franklin and Electrostatics was recently reviewed in the June 2006 issue of Natural History Magazine. A previous foray into poetry, "The Pool Table Physics Lab Rap," is one of the pieces on the Physics Pholk Songs CD, part of the Activity-Based Physics project.

  20. Edible oils for liver protection: hepatoprotective potentiality of Moringa oleifera seed oil against chemical-induced hepatitis in rats.

    PubMed

    Al-Said, Mansour S; Mothana, Ramzi A; Al-Yahya, Mohammed A; Al-Blowi, Ali S; Al-Sohaibani, Mohammed; Ahmed, Atallah F; Rafatullah, Syed

    2012-07-01

    In the present study, in vitro antioxidant, antioxidative stress and hepatoprotective activity of Moringa oleifera Lam. seed oil (Ben oil; BO) was evaluated against carbon tetrachloride (CCl(4) ) induced lipid peroxidation and hepatic damage in rats. The oil at 0.2 and 0.4 mL/rat was administered orally for 21 consecutive days. The substantially elevated serum enzymatic (GOT, GPT, ALP, GGT) and bilirubin levels were significantly restored towards normalization by the oil. There was a significant elevation in the level of malondialdehyde (MDA), non-protein sulfhydryl (NP-SH), and total protein (TP) contents in the liver tissue. The results obtained indicated that BO possesses potent hepatoprotective action against CCl(4) -induced hepatic damage by lowering liver marker enzymes, MDA concentration, and elevating NP-SH and TP levels in liver tissue. The biochemical observations were supplemented with histopathological examination of rat liver. The results of this study showed that treatment with Ben oil or silymarin (as a reference) appears to enhance the recovery from hepatic damage induced by CCl(4) . The pentobarbital induced narcolepsy prolongation in mice was retarded by the Ben oil. Acute toxicity test in mice showed no morbidity or mortality. In vitro DPPH radical scavenging and β-carotene-linolic acid assay tests of the BO exhibited a moderate antioxidant activity in both tests used. The possible mechanism(s) of the liver protective activity of Ben oil activity may be due to free radical scavenging potential caused by the presence of antioxidant component(s) in the oil. Consequently, BO can be used as a therapeutic regime in treatment of some hepatic disorders. PMID:22757719

  1. Enhancement of nutritionally significant constituents of black currant seeds by chemical elicitor application.

    PubMed

    Flores, Gema; Ruiz del Castillo, María Luisa

    2016-03-01

    Black currant seeds are obtained as a residue during juice production. Black currant seed oil contains high amounts of nutritionally desirable constituents such as γ-linolenic acid (GLA), α-linolenic acid (ALA) and stearidonic acid (SA), as well as certain phenolic acids, which act as natural antioxidants. Fatty acids and phenolic acids of seeds from black currant cultivars after elicitation with methyl jasmonate (MJ) were examined. GLA contents around 25% with respect to total fatty acid content were measured in seeds after pre-harvest treatment of black currants with 0.02mM MJ in 0.05% Tween-20. High GLA samples also exhibited high SA content (higher than 10% with respect to total fatty acid content); however, ALA dropped (from 16% to 10%). High GLA content seeds also showed increased contents of gallic, caffeic, p-coumaric and ferulic acids. In particular, seeds from 0.02mM MJ treated Ben Hope black currants exerted contents of gallic, caffeic, p-coumaric and ferulic acids of 201.4, 125.9, 201.3 and 112.5μgg(-1)vs 124.3, 58.6, 165.4 and 95.8μgg(-1) measured in seeds from untreated Ben Hope black currants. Comparable results were obtained for Ben Alder and Ben Gairn berries. Chemical elicitation with 0.02 MJ is proposed as an industrial practice in such a way that, after consideration of quality issues, it would be obtained high added value black currant seeds. PMID:26471680

  2. Space elevator radiation hazards and how to mitigate them.

    SciTech Connect

    Jorgensen, A. M.; Gassend, B.; Friedel, R. H. W.; Cayton, T. E.; Patamia, S. E.

    2004-01-01

    The conclusions of this paper are: (1) the radiation field is severe; (2) shielding with aluminium is not economical; (3) shielding with a magnetic field may be feasible; (4) reducing dose by going gaster is not very effective; (5) larger/heavier climbers are more efficient when shielding with a heavy material (contrary requirement to talk by Ben Shelef); (6) climber mass and cost to orbit are impacted; and (7) power requirement could be impacted.

  3. Solids Far from Equilibrium

    NASA Astrophysics Data System (ADS)

    Godrèche, C.

    2011-03-01

    Preface; 1. Shape and growth of crystals P. Nozières; 2. Instabilities of planar solidification fronts B. Caroli, C. Caroli and B. Roulet; 3. An introduction to the kinetics of first-order phase transition J. S. Langer; 4. Dendritic growth and related topics Y. Pomeau and M. Ben Amar; 5. Growth and aggregation far from equilibrium L. M. Sander; 6. Kinetic roughening of growing surfaces J. Krug and H. Spohn; Acknowledgements; References; Index.

  4. Lattice QCD simulations on big cats, sea monsters and clock towers

    NASA Astrophysics Data System (ADS)

    Joó, Bálint; USQCD Collaboration; Hadron Spectrum Collaboration

    2009-07-01

    We present details of lattice QCD computations we are performing on the Cray XT series of computers, from BigBen - an XT3 hosted at the Pittsburgh Supercomputing Center (PSC) - through Jaguar (XT4) and Kraken (XT5) - which are hosted at the National Center for Computational Science (NCCS) and the National Institute of Computational Science (NICS), respectively, at Oak Ridge National Laboratory (ORNL). We discuss algorithmic tuning to make the computation more efficient and present some recent results.

  5. Cliff Joslyn on the Global Brain

    SciTech Connect

    Joslyn, Cliff A.; Goertzel, Ben

    2012-02-24

    This is an interview I did with Ben Goertzel, an old friend and editor of the H+ electronic journal on technological, scientific, and cultural trends that are changing human beings. It's published by Humanity+, the world’s leading nonprofit for the ethical use of technology to extend human capabilities. It concerns some of my work in cybernetic technology and knowledge systems from the early 1990's, with some implications for my current work.

  6. Cliff Joslyn on the Global Brain

    SciTech Connect

    Joslyn, Cliff A.

    2012-01-24

    This is an interview I did with Ben Goertzel, an old friend and editor of the H+ electronic journal on technological, scientific, and cultural trends that are changing human beings. It's published by Humanity+, the world’s leading nonprofit for the ethical use of technology to extend human capabilities. It concerns some of my work in cybernetic technology and knowledge systems from the early 1990's, with some implications for my current work.

  7. Soldier sentenced for exposing eight sex partners to HIV.

    PubMed

    1998-04-01

    An HIV-positive Army soldier at Fort Benning, GA was sentenced to 15 years in prison after admitting to having unprotected sex with at least 8 women. [Name removed] pleaded guilty at his court martial to charges of aggravated assault, sodomy, adultery, and disobeying orders. The women said [name removed] never told them that he was HIV-positive. Four of the women became pregnant. One miscarried, and one delivered an HIV-infected baby. PMID:11365240

  8. The potential energy surface and chaos in 2D Hamiltonian systems

    NASA Astrophysics Data System (ADS)

    Li, Jiangdan; Zhang, Suying

    2011-02-01

    We provide a new insight into the relationship between the geometric property of the potential energy surface and chaotic behavior of 2D Hamiltonian dynamical systems, and give an indicator of chaos based on the geometric property of the potential energy surface by defining Mean Convex Index (MCI). We also discuss a model of unstable Hamiltonian in detail, and show our results in good agreement with HBLSL's (Horwitz, Ben Zion, Lewkowicz, Schiffer and Levitan) new Riemannian geometric criterion.

  9. The Day After

    NASA Astrophysics Data System (ADS)

    Shostak, Seth

    1996-03-01

    It could happen tomorrow, or in a hundred years. Astronomers may discover we are not alone in the universe. It is a prospect made even more likely by the recent discoveries of bona fide planets around other stars, and Mercury wants our readers to be ready. With sidebars by Ben Bova; James M. Cordes, T. Joseph W. Lazio, and Carl Sagan; and H. Paul Shuch.

  10. The Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF): incremental validity in predicting early postoperative outcomes in spine surgery candidates.

    PubMed

    Marek, Ryan J; Block, Andrew R; Ben-Porath, Yossef S

    2015-03-01

    A substantial proportion of individuals who undergo surgical procedures to relieve spine pain continue to report significant pain and dysfunction after recovery. Psychopathology and patient expectations have been linked to poor results, leading to an increasing reliance on presurgical psychological screening (PPS) as part of the surgical diagnostic process. The original Minnesota Multiphasic Personality Inventory (MMPI; Hathaway & McKinley, 1943) and the MMPI-2 (Butcher, Graham, Ben-Porath, Tellegen, & Dahlstrom, 2001) were among the measures most commonly used in PPS evaluations and research. This study focuses on the newest version of the test, the MMPI-2-Restructured Form (MMPI-2-RF; Ben-Porath & Tellegen, 2008/2011; Tellegen & Ben-Porath, 2008/2011) as a predictor of outcomes for spine surgery candidates. Using a sample of 172 men and 210 women who underwent a PPS, we examined the ability of MMPI-2-RF scale scores to predict early surgical outcomes independent of other presurgical risk factors identified by other means, as well as patients' presurgical expectations. MMPI-2-RF results accounted for up to 11% of additional variance in measures of early postoperative functioning. MMPI-2-RF scales that assess for emotional/internalizing problems, specifically Demoralization, measures of somatoform dysfunction, and interpersonal problems contributed most to the prediction of diminished outcome. PMID:25364871

  11. Experimental characterization of broadband electrostatic noise due to plasma compression

    NASA Astrophysics Data System (ADS)

    Dubois, Ami M.; Thomas, Edward, Jr.; Amatucci, William E.; Ganguli, Gurudas

    2015-11-01

    For a wide variety of laboratory and space plasma environments, theory states that plasmas are unstable to transverse shear flows over a very broad frequency range, where the shear scale length (LE) compared to the ion gyro-radius (ρi) determines the character of the shear-driven instability that may prevail. During active periods in the Earth's magnetosphere, such sheared flows are intensified and broadband electrostatic noise (BEN) is often observed by satellites traversing natural boundary layers. An interpenetrating magnetized plasma configuration is used to create a transverse velocity shear profile similar to that found at natural space plasma boundary layers. The continuous variation and the associated transition of the instability regimes driven by the shear flow mechanism are demonstrated in a single laboratory experiment. For the first time, broadband wave emission, which is correlated to increasing/decreasing stress (i.e., ρi/LE) on a plasma boundary layer, is found under controlled and repeatable conditions. This result provides evidence that the compression/relaxation of a plasma boundary layer leads to a BEN signature and holds out the promise for understanding the cause and effect of the in situ observation of BEN by satellites. This project was supported with funding from the U.S. Department of Energy, the Defense Threat Reduction Agency, and NRL Base Funds.

  12. Cleavage of spike protein of SARS coronavirus by protease factor Xa is associated with viral infectivity

    SciTech Connect

    Du, Lanying; Kao, Richard Y.; Zhou, Yusen; He, Yuxian; Zhao, Guangyu; Wong, Charlotte; Jiang, Shibo; Yuen, Kwok-Yung; Jin, Dong-Yan; Zheng, Bo-Jian . E-mail: bzheng@hkucc.hku.hk

    2007-07-20

    The spike (S) protein of SARS coronavirus (SARS-CoV) has been known to recognize and bind to host receptors, whose conformational changes then facilitate fusion between the viral envelope and host cell membrane, leading to viral entry into target cells. However, other functions of SARS-CoV S protein such as proteolytic cleavage and its implications to viral infection are incompletely understood. In this study, we demonstrated that the infection of SARS-CoV and a pseudovirus bearing the S protein of SARS-CoV was inhibited by a protease inhibitor Ben-HCl. Also, the protease Factor Xa, a target of Ben-HCl abundantly expressed in infected cells, was able to cleave the recombinant and pseudoviral S protein into S1 and S2 subunits, and the cleavage was inhibited by Ben-HCl. Furthermore, this cleavage correlated with the infectivity of the pseudovirus. Taken together, our study suggests a plausible mechanism by which SARS-CoV cleaves its S protein to facilitate viral infection.

  13. Diversity and Complexity in Chromatin Recognition by TFII-I Transcription Factors in Pluripotent Embryonic Stem Cells and Embryonic Tissues

    PubMed Central

    Makeyev, Aleksandr V.; Enkhmandakh, Badam; Hong, Seung-Hyun; Joshi, Pujan; Shin, Dong-Guk; Bayarsaihan, Dashzeveg

    2012-01-01

    GTF2I and GTF2IRD1 encode a family of closely related transcription factors TFII-I and BEN critical in embryonic development. Both genes are deleted in Williams-Beuren syndrome, a complex genetic disorder associated with neurocognitive, craniofacial, dental and skeletal abnormalities. Although genome-wide promoter analysis has revealed the existence of multiple TFII-I binding sites in embryonic stem cells (ESCs), there was no correlation between TFII-I occupancy and gene expression. Surprisingly, TFII-I recognizes the promoter sequences enriched for H3K4me3/K27me3 bivalent domain, an epigenetic signature of developmentally important genes. Moreover, we discovered significant differences in the association between TFII-I and BEN with the cis-regulatory elements in ESCs and embryonic craniofacial tissues. Our data indicate that in embryonic tissues BEN, but not the highly homologous TFII-I, is primarily recruited to target gene promoters. We propose a “feed-forward model” of gene regulation to explain the specificity of promoter recognition by TFII-I factors in eukaryotic cells. PMID:22970219

  14. Divergent trend in density versus viscosity of ionic liquid/water mixtures: a molecular view from guanidinium ionic liquids.

    PubMed

    Singh, Akhil Pratap; Gardas, Ramesh L; Senapati, Sanjib

    2015-10-14

    Ionic liquids (ILs) have shown great potential in the dissolution and stability of biomolecules when a low-to-moderate quantity of water is added. Hence, determining the thermophysical properties and understanding these novel mixtures at the molecular level are of both fundamental and practical importance. In this context, here we report the synthesis of two nontoxic guanidinium cation based ILs, tetramethylguanidinium benzoate [TMG][BEN] and tetramethylguanidinium salicylate [TMG][SAL], and present a detailed comparison of their thermophysical properties in the presence of water. The results show that the [TMG][SAL]/water mixtures have higher density and higher apparent molar volume, but a lower viscosity and higher compressibility than the [TNG][BEN]/water mixtures. The measured viscosity and compressibility data are explained from ab initio quantum mechanical calculations and liquid-phase molecular dynamics simulations, where salicylate anions of denser [TMG][SAL]/water were found to exist as isolated ions due to intramolecular H-bonding. On the contrary, intermolecular H-bonding among the benzoate anions and their strong tendency to form an extended H-bonding network with water made [TMG][BEN]/water solutions more viscous and less compressible. This study shows the importance of probing these emerging solvents at the molecular-to-atomic level, which could be helpful in their optimal usage for task-specific applications. PMID:26347332

  15. A theoretical study of π-stacking interactions in C-substituted tetrazoles.

    PubMed

    Farrokhzadeh, Abdolkarim; Modarresi-Alam, Ali Reza; Akher, Farideh Badichi; Ebrahimi, Ali

    2016-06-01

    The π-stacking effects of benzene ring (Ben) with 1H- and 2H-tetrazole derivatives (1H-TZ-X and 2H-TZ-X) substituted at C5 (where X is Cl, COH, NO, NO2, CN, NH2, OH, OCH3, SH and H) has been investigated by the quantum mechanical calculations at the M06-2X/6-311++G** level. The results indicate the 1H-TZ-X||Ben complexes (|| donates π-stacking interaction) are more stable than 2H-TZ-X||Ben while in unstacked forms, 1H-TZ-X is less stable than 2H-TZ-X. All substituents enhance the π-stacking interaction relative to the unsubstituted ones and enhancement is higher for the electron-withdrawing substituents (EWSs). Also, investigation of the local and direct effect of substituents in stacking interaction showed that all substituents regardless of whether are electron donating or electron withdrawing have an additive effect in π-stacking interaction. Excellent correlations were found between the binding energies of the complexes and combination of substituent constant terms. The results showed that the electrostatic interaction alone is not responsible for stacking stabilization but charge penetration is important. Furthermore, analysis of aromaticity, AIM, ESP and NPA were investigated to obtain aromaticity index, non-bonding interactions, chemical reactivity and polarity (dipole moment), respectively. PMID:27258189

  16. [Textual research on the literature sources, its related names and medicinal part of Lonicera japonica Thunb].

    PubMed

    Wang, Peng; Zhou, Yang; Fu, Xian-Jun; Wang, Zhen-Guo

    2013-05-01

    The "jin yin hua" (Lonicera japonica Thunb.) used in the clinic nowadays is the flower of honeysuckle, excluding its stem, leave, branch, vine or the whole plant. In the early time, the name of "ren dong" (honeysuckle) or "ren dong teng" (Caulis lonicerae) didn't refer exclusively to the flower of honeysuckle. A few early literature, such as Xin xiu ben cao (Newly Revised Materia Medica) recorded briefly the flower, yet only mentions its time of blossom and shape without mentioning the medicinal use of its flower, nor the title of "jin yin hua", as the identification for this plant. Therefore, it cannot be regarded as the primary source of "jin yin hua". This research points out that the first appearance of the name of "jin yin hua" should be in Su shen liang fang (Su-Shen's Effective Prescriptions) of the Song Dynasty, and the first usage of the flower "jin yin hua" as a single drug was in Wai ke jing yao (Essence of External Diseases) of the Song Dynasty. Thus, the conclusion that "jin yin hua" is first seen in Xin xiu ben cao or lv chan yan ben cao (Mountainous Materia Medica) quoted in the ninth edition of teaching material of Traditional Chinese Pharmacology, and Chinese Materia Medica are all wrong and should be corrected accordingly. PMID:24060026

  17. Experimental study to explore the 8Be-induced nuclear reaction via the Trojan horse method

    NASA Astrophysics Data System (ADS)

    Wen, Qun-Gang; Li, Cheng-Bo; Zhou, Shu-Hua; Irgaziev, Bakhadir; Fu, Yuan-Yong; Spitaleri, Claudio; La Cognata, Marco; Zhou, Jing; Meng, Qiu-Ying; Lamia, Livio; Lattuada, Marcello

    2016-03-01

    To explore a possible indirect method for 8Be induced astrophysical reactions, the 8Be=(8Be+n ) cluster structure has been studied via the Trojan horse method. For the first time a 8Be nucleus having an ultrashort lifetime is studied by the Trojan horse method and a 9Be nucleus in the ground state is used for this purpose. The 9Be nucleus is assumed to have a (8Be+n ) cluster structure and used as a Trojan horse nucleus. The 8Be nucleus acts as a participant, while the neutron is a spectator to the virtual 8Be+d →α +6Li reaction via the 3-body reaction 8Be+d →α +6Li+n . The experimental neutron momentum distribution inside 9Be has been reconstructed. The agreement between the experimental momentum distribution and the theoretical one indicates that a (8Be+n ) cluster structure inside 9Be is very likely. Therefore, the experimental study of 8Be induced reactions, for example, the measurement of the 8Be+α →12C reaction proceeding through the Hoyle state, is possible.

  18. Mode de mise en place des corps salifères dans l'Atlas septentrional de Tunisie. Exemple de l'appareil de Bir Afou

    NASA Astrophysics Data System (ADS)

    Ben Chelbi, Mohamed; Melki, Fetheddine; Zargouni, Fouad

    2006-05-01

    30 km southwest of Tunis, two thin flaky 'Triassic' intrusions underline the two flanks of the Atlasic anticline of Bir Afou. These evaporites are interbedded within the Clansayesian shales, and are under and overlain by glauconitic conglomeratic contacts. The 'Triassic' flakes, topic of our study, are sourced from the Bir Afou Triassic mass after a rapid pouring out during Late Aptian extensional tectonics. This structure corresponds, for us, to a 'salt glacier', similar to that one described at Ben Gasseur by Vila and al. [J.M. Vila, M. Ben Youssef, M. Chikhaoui, M. Ghanmi, Bull. Soc. géol. France 167 (1996) 235-246], which was subsequently folded during Lower Eocene times. Middle and Upper Eocene transgressive formations unconformably deposited on top of the Aptian anticlinal hinge. The major Late Miocene compressive phase is responsible for the present structures and that are superimposed onto the pre-existing 'salt glacier'. This salifereous system extends the 'salt glacier' domain towards the eastern part of the Tunisian Atlas. To cite this article: M. Ben Chelbi et al., C. R. Geoscience 338 (2006).

  19. [Evolution of the Origin of Herba Schizonepetae].

    PubMed

    Song, X W; Li, G Y; Wang, D Q; Han, B X

    2016-05-01

    Herba Schizonepetae was firstly recorded in the Sheng nong ben caojing (Shennong's Materia Medica) with the title Jiasu. It could be sure that the original plant of Jiasu is Ocimumbasilicum L. ofLabiatae based on the record of Jiasu's name, morphology, edible property before the Song Dynasty. Beginning from the Ben cao tu jing (Illustrated Classic of Materia Medica) in the Song Dynasty, the source of this drug evolved as SchizonepetatenuisfoliaBriq. ofLabiatae, and it has been in use until now. Hence, the sources of Jiasu should be both O. basilicum L. and the co-existence of S. tenuisfolia Briq in the Qing Dynasty. It is claimed that the hometowns of those herb writers who considered the source ofOcimumbasilicum L. to be the producing areas of cultivation of the edible Ocimumbasilicum L. It was found that the source of Jiasu recorded in the Sheng nong ben cao jing should be O. basilicum L. , hence, it is suggested the title Jiasu should be recorded for the source of O. basilicum L, and the original plant of Herba Schizonepetae was Schizonepetatenuisfolia Briq. of Labiatae, and this medicine should be separately recorded. In fact, Jiasu and Herba Schizonepetae were two different kinds of medicines. PMID:27485864

  20. Learning to teach science in urban schools by becoming a researcher of one's own beginning practice

    NASA Astrophysics Data System (ADS)

    Furman, Melina; Calabrese Barton, Angela; Muir, Ben

    2012-03-01

    An urgent goal for science teacher educators is to prepare teachers to teach science in meaningful ways to youth from nondominant backgrounds. This preparation is challenging, for it asks teachers to critically examine how their pedagogical practices might adaptively respond to students and to science. It asks, essentially, for new teachers to become researchers of their own beginning practice. This study explores the story of Ben as he coauthored a transformative action research project in an urban middle school as part of a teacher education program and, later, over his first year of teaching at that same school. We describe how Ben and his partner teacher created innovative spaces for science learning. This offered Ben an opportunity to make some of his deeply engrained pedagogical beliefs come alive within a context of distributed expertise, which provided for him a space of moderate risk where he could afford the chances of failure without undermining how he felt about his own capacity as a teacher. Our study highlights the importance of creating reform opportunities within the context of teacher education programs that may help beginner teachers construct positive images of teaching that they can hold on to in their future practice.

  1. Changing the content of phenolic compounds as the response of blackcurrant (Ribes nigrum L.) leaves after blackcurrant leaf midge (Dasineura tetensi Rübs.) infestation.

    PubMed

    Piotrowski, Wojciech; Oszmiański, Jan; Wojdyło, Aneta; Łabanowska, Barbara H

    2016-09-01

    Blackcurrant leaf midge (Dasineura tetensi) is one of the most common pests of blackcurrant (Ribes nigrum). The aim of this study was to investigate changes in the content of phenolic compounds in the leaves damaged by the larvae of this pest. Additionally, susceptibility of different blackcurrant cultivars to the midge attack was investigated. Qualitative and quantitative analyses of control and pest-infested blackcurrant leaves were performed using LC-PDA-QTOF/MS and UPLC-PDA-FL systems. A total of 39 types of phenolic compounds were identified in blackcurrant leaf extracts and they included 3 flavan-3-ols, 14 hydroxycinnamic acid derivatives, and 22 flavonols. Feeding of blackcurrant leaf midge on blackcurrant leaves lowered the content of leaf polyphenolic compounds. The greatest differences in polyphenolics between control and infected leaves were observed in 'Ruben', 'Fariegh', 'Foxendown', 'Ores', 'Ben Hope', 'Ben Connan' and 'Tisel' cultivars that were probably highly susceptible to the pest attack. In the other cultivars: 'Ben Finlay', 'Polares', 'Tiben', and 'Gofert' the differences in phenolics content were less pronounced, so they were probably less susceptible to D. tetensi attack. Plant polyphenolic compounds was strongly involved in pathogen-plant interaction, and their accumulation significantly decreased as a result of the pathogen attack. PMID:27161581

  2. Coexpression Network Analysis of Benign and Malignant Phenotypes of SIV-Infected Sooty Mangabey and Rhesus Macaque

    PubMed Central

    Silvestri, Guido; Bosinger, Steven E.; Li, Bai-Lian; Jong, Ambrose; Zhou, Yan-Hong; Huang, Sheng-He

    2016-01-01

    To explore the differences between the extreme SIV infection phenotypes, nonprogression (BEN: benign) to AIDS in sooty mangabeys (SMs) and progression to AIDS (MAL: malignant) in rhesus macaques (RMs), we performed an integrated dual positive-negative connectivity (DPNC) analysis of gene coexpression networks (GCN) based on publicly available big data sets in the GEO database of NCBI. The microarray-based gene expression data sets were generated, respectively, from the peripheral blood of SMs and RMs at several time points of SIV infection. Significant differences of GCN changes in DPNC values were observed in SIV-infected SMs and RMs. There are three groups of enriched genes or pathways (EGPs) that are associated with three SIV infection phenotypes (BEN+, MAL+ and mixed BEN+/MAL+). The MAL+ phenotype in SIV-infected RMs is specifically associated with eight EGPs, including the protein ubiquitin proteasome system, p53, granzyme A, gramzyme B, polo-like kinase, Glucocorticoid receptor, oxidative phosyphorylation and mitochondrial signaling. Mitochondrial (endosymbiotic) dysfunction is solely present in RMs. Specific BEN+ pattern changes in four EGPs are identified in SIV-infected SMs, including the pathways contributing to interferon signaling, BRCA1/DNA damage response, PKR/INF induction and LGALS8. There are three enriched pathways (PRR-activated IRF signaling, RIG1-like receptor and PRR pathway) contributing to the mixed (BEN+/MAL+) phenotypes of SIV infections in RMs and SMs, suggesting that these pathways play a dual role in the host defense against viral infections. Further analysis of Hub genes in these GCNs revealed that the genes LGALS8 and IL-17RA, which positively regulate the barrier function of the gut mucosa and the immune homeostasis with the gut microbiota (exosymbiosis), were significantly differentially expressed in RMs and SMs. Our data suggest that there exists an exo- (dysbiosis of the gut microbiota) and endo- (mitochondrial dysfunction

  3. Obituary: Benjamin Franklin Peery Jr. (1922-2010)

    NASA Astrophysics Data System (ADS)

    Cowley, Charles

    2011-12-01

    Professor Benjamin F. Peery, Jr. died at his home in Silver Spring, MD of natural causes on 30 November 2010. His full life began in St. Joseph, MO (home of the Pony Express) on 4 March 1922. His father was a railway mail clerk, so his family moved frequently. Most of his childhood was spent in southeastern Minnesota. He enlisted in the army in 1942, and served in campaigns in North Africa and Italy. After his discharge in 1945, he enrolled in the University of Minnesota, earning a BS in Physics in 1949. One of his early hobbies was to build and fly model airplanes. His intention to pursue aeronautical engineering changed to physics, but after receiving a MS in physics from Fisk University in 1955, he decided on a career in astronomy. He told the editors of the PBS series The Astronomers (1991, in which his career is highlighted) he thought it was shamefully absurd not to know what made the stars shine. So he began PhD studies in astronomy at the University of Michigan (Ann Arbor). His dissertation was on the complex eclipsing binary VV Cephei, where a compact hot star passes behind a cool giant star, revealing the structure of that giant's atmosphere. This task was especially demanding because of the complexity of the system's spectrum and the formidable array of observations assembled by Ben's advisor, Dean McLaughlin. Fortunately, Ben's strong physics background enabled him to design and construct one of the first oscilloscope measuring engines, which his fellow students called the PeeryScope. The final (1961) dissertation is an impressive combination of observational and astrophysical analysis. His degree was obtained in 1962; he had already begun a career at the University of Indiana, where he taught and did research (1959--1976). The Indiana years were highly productive. In addition to his own research, he was advisor on six PhD dissertations, and a master's thesis. Several of his students have also had productive careers. An ADS search on his students' names

  4. A State-of-the-Knowledge Review on Pseudo-Steady Shock-Wave Reflections and their Transition Criteria

    NASA Astrophysics Data System (ADS)

    Ben-Dor, G.

    2006-07-01

    1991 Ben-Dor published a monograph, entitled “ Shock Wave Reflection Phenomena”, that was, in fact, a state-of-the-knowledge review of the phenomena. This state-of-the-knowledge will be referred to in the followings as the “old”-state-of-the-knowledge (This state-of-the-knowledge existed until the mid 1990s. A few years later Li and Ben-Dor (Shock Wave 5(1/2), 59-73, 1995) modified the analytical approach for evaluating the transition criteria from the single-Mach to the transitional- Mach reflection (SMR, rightleftarrows,TMR) and from the transitional-Mach to the double-Mach reflection (TMR, rightleftarrows ,DMR) and presented some modified and new criteria for the formation and termination of both the TMR and DMR wave configurations. Experimental results from various sources revealed that the transition boundaries between the SMR, TMR and DMR wave configurations that were based on the modified analytical approach were better than those of the “old” state-of-the-knowledge that as mentioned earlier was summarized in Ben-Dor’s (Shock Wave Reflection Phenomena, Springer, 1991) monograph. Unfortunately, however, the results of Li and Ben-Dor’s (Shock Wave 5(1/2), 59-73, 1995) modified analytical approach have not been internalized, and publications by various scientists in the past decade neglected the revised and better transition criteria and kept on referring to the old and wrong criteria that appeared in Ben-Dor’s (Shock Wave Reflection Phenomena, Springer, 1991) monograph. For this reason, a state-of-the-knowledge review that is based on the above-mentioned 10-year-old findings of Li and Ben-Dor (Shock Wave 5(1/2), 59-73, 1995) is presented herein. At the first step, the “old” state-of-the-knowledge is presented.

  5. Electrospun nanofibrous scaffolds increase the efficacy of stem cell-mediated therapy of surgically resected glioblastoma.

    PubMed

    Bagó, Juli R; Pegna, Guillaume J; Okolie, Onyi; Mohiti-Asli, Mahsa; Loboa, Elizabeth G; Hingtgen, Shawn D

    2016-06-01

    Engineered stem cell (SC)-based therapy holds enormous promise for treating the incurable brain cancer glioblastoma (GBM). Retaining the cytotoxic SCs in the surgical cavity after GBM resection is one of the greatest challenges to this approach. Here, we describe a biocompatible electrospun nanofibrous scaffold (bENS) implant capable of delivering and retaining tumor-homing cytotoxic stem cells that suppress recurrence of post-surgical GBM. As a new approach to GBM therapy, we created poly(l-lactic acid) (PLA) bENS bearing drug-releasing human mesenchymal stem cells (hMSCs). We discovered that bENS-based implant increased hMSC retention in the surgical cavity 5-fold and prolonged persistence 3-fold compared to standard direct injection using our mouse model of GBM surgical resection/recurrence. Time-lapse imaging showed cytotoxic hMSC/bENS treatment killed co-cultured human GBM cells, and allowed hMSCs to rapidly migrate off the scaffolds as they homed to GBMs. In vivo, bENS loaded with hMSCs releasing the anti-tumor protein TRAIL (bENS(sTR)) reduced the volume of established GBM xenografts 3-fold. Mimicking clinical GBM patient therapy, lining the post-operative GBM surgical cavity with bENS(sTR) implants inhibited the re-growth of residual GBM foci 2.3-fold and prolonged post-surgical median survival from 13.5 to 31 days in mice. These results suggest that nanofibrous-based SC therapies could be an innovative new approach to improve the outcomes of patients suffering from terminal brain cancer. PMID:27016620

  6. 3-Chlorobenzoate is taken up by a chromosomally encoded transport system in Cupriavidus necator JMP134.

    PubMed

    Ledger, T; Aceituno, F; González, B

    2009-08-01

    Cupriavidus necator JMP134(pJP4) is able to grow on 3-chlorobenzoate (3-CB), a model chloroaromatic pollutant. Catabolism of 3-CB is achieved via the expression of the chromosomally encoded benABCD genes and the tfd genes from plasmid pJP4. Since passive diffusion of benzoic acid derivatives at physiological pH is negligible, the uptake of this compound should be facilitated by a transport system. However, no transporter has so far been described to perform this function, and identification of chloroaromatic compound transporters has been limited. In this work, uptake experiments using 3-[ring-UL-(14)C]CB showed an inducible transport system in strain JMP134, whose expression is activated by 3-CB and benzoate. A similar level of 3-CB uptake was found for a mutant strain of JMP134, defective in chlorobenzoate degradation, indicating that metabolic drag is not an important component of the measured uptake rate. Competitive inhibitor assays showed that uptake of 3-CB was inhibited by benzoate and, to a lesser degree, by 3-CB and 3,5-dichlorobenzoate, but not by any of 12 other substituted benzoates tested. The expression of several gene candidates for this transport function was analysed by RT-PCR, including both permease-type and ABC-type ATP-dependent transporters. Induction of a chromosomally encoded putative permease transporter (benP gene) was found specifically in the presence of 3-CB or benzoate. A benP knockout mutant of strain JMP134 displayed an almost complete loss of 3-CB transport activity. This is to our knowledge the first report of a 3-CB transporter. PMID:19423632

  7. Desire for social contact, not empathy, may explain "rescue" behavior in rats.

    PubMed

    Silberberg, Alan; Allouch, Candice; Sandfort, Samantha; Kearns, David; Karpel, Heather; Slotnick, Burton

    2014-05-01

    Ben-Ami Bartal et al. (Science 334:1427-1430, 2011) showed that a rat in an open space (free rat) would touch the front door of a restraining tube to open its rear door, thereby enabling a rat trapped within (trapped rat) to enter a larger space that was farther away from the free rat. Since opening the rear door distanced the trapped rat from the free rat, Ben-Ami Bartal et al. argued free-rat behavior could not be motivated by the pursuit of social contact. Instead, this rat was empathically motivated, its goal being to reduce the presumed distress of the rat trapped in the restraining tube. In two experiments, we show that (a) a free rat will not learn to touch the front door to open the rear door when it is the first condition of the experiment; (b) over time, a trapped rat will often return to a restraining tube despite its presumed aversiveness; and (c) a free rat experienced in touching the front door will continue to touch it even if touching does not free the trapped rat. We explain these results and Ben-Ami Bartal et al.'s in terms of two processes, neophobia and the pursuit of social contact. When first placed in a restraining tube, neophobia causes the trapped rat to escape the tube when the rear door is opened. Across sessions, neophobia diminishes, permitting the rats' pursuit of social contact to emerge and dominate free- and trapped-rat behavior. PMID:24126919

  8. Hysteresis processes in the regular reflection↔Mach reflection transition in steady flows

    NASA Astrophysics Data System (ADS)

    Ben-Dor, G.; Ivanov, M.; Vasilev, E. I.; Elperin, T.

    2002-05-01

    Ernst Mach recorded experimentally, in the late 1870s, two different shock-wave reflection configurations and laid the foundations for one of the most exciting and active research field in an area that is generally known as Shock Wave Reflection Phenomena. The first wave reflection, a two-shock wave configuration, is known nowadays as regular reflection, RR, and the second wave reflection, a three-shock wave configuration, was named after Ernst Mach and is called nowadays Mach reflection, MR. A monograph entitled Shock Wave Reflection Phenomena, which was published by Ben-Dor in 1990, summarized the state-of-the-art of the reflection phenomena of shock waves in steady, pseudo-steady and unsteady flows. Intensive analytical, experimental and numerical investigations in the last decade, which were led mainly by Ben-Dor's research group and his collaboration with Chpoun's, Zeitoun's and Ivanov's research groups, shattered the state-of-the-knowledge, as it was presented in Ben-Dor (Shock Wave Reflection Phenomena, Springer, New York, 1991), for the case of steady flows. Skews's and Hornung's research groups joined in later and also contributed to the establishment of the new state-of-the-knowledge of the reflection of shock waves in steady flows. The new state-of-the-knowledge will be presented in this review. Specifically, the hysteresis phenomenon in the RR↔MR transition process, which until the early 1990s was believed not to exist, will be presented and described in detail, in a variety of experimental set-ups and geometries. Analytical, experimental and numerical investigations of the various hysteresis processes will be presented.

  9. Fabrication of coated bovine serum albumin (BSA)-epigallocatechin gallate (EGCG) nanoparticles and their transport across monolayers of human intestinal epithelial Caco-2 cells.

    PubMed

    Li, Zheng; Ha, Jungheun; Zou, Tao; Gu, Liwei

    2014-06-01

    The bovine serum albumin (BSA)-epigallocatechin gallate (EGCG) nanoparticles were fabricated using a desolvation method, and coated with poly-ε-lysine or chitosan. BSA-EGCG nanoparticles (BEN), poly-ε-lysine coated BSA-EGCG nanoparticles (PBEN), and chitosan coated BSA-EGCG nanoparticles (CBEN) had a spherical morphology and a size of 186, 259, and 300 nm, respectively. The loading efficiency of EGCG in these nanoparticles was 32.3%, 35.4%, and 32.7%, whereas the loading capacity was 18.9%, 17.0%, and 16.0% (w/w), respectively. Poly-ε-lysine or chitosan coating prevented the aggregation of nanoparticles at pH 4.5-5.0. However, they caused particle aggregation at pH 6.5-7.0. BEN had negative zeta-potentials between pH 4.5 and 6.0. Poly-ε-lysine or chitosan coating changed the zeta-potentials to positive. The release study of EGCG from the nanoparticles in the simulated gastric or intestinal fluid with or without digestive enzymes showed that poly-ε-lysine and chitosan coatings delayed EGCG release from the nanoparticles. Poly-ε-lysine or chitosan coating improved the stability of EGCG during storage at 60 °C compared with EGCG in the uncoated particles. EGCG in BEN, PBEN, and CBEN had a decreasing apparent permeability coefficient (Papp) on Caco-2 monolayers, whereas pure EGCG showed relatively stable Papp during the incubation over time. EGCG in CBEN showed significantly higher Papp, suggesting that chitosan coated BSA-EGCG nanoparticles may improve the absorption of EGCG. PMID:24741679

  10. β-globin haplotypes in normal and hemoglobinopathic individuals from Reconcavo Baiano, State of Bahia, Brazil

    PubMed Central

    2010-01-01

    Five restriction site polymorphisms in the β-globin gene cluster (HincII-5‘ ε, HindIII-G γ, HindIII-A γ, HincII- ψβ1 and HincII-3‘ ψβ1) were analyzed in three populations (n = 114) from Reconcavo Baiano, State of Bahia, Brazil. The groups included two urban populations from the towns of Cachoeira and Maragojipe and one rural Afro-descendant population, known as the “quilombo community”, from Cachoeira municipality. The number of haplotypes found in the populations ranged from 10 to 13, which indicated higher diversity than in the parental populations. The haplotypes 2 (+ - - - -), 3 (- - - - +), 4 (- + - - +) and 6 (- + + - +) on the βA chromosomes were the most common, and two haplotypes, 9 (- + + + +) and 14 (+ + - - +), were found exclusively in the Maragojipe population. The other haplotypes (1, 5, 9, 11, 12, 13, 14 and 16) had lower frequencies. Restriction site analysis and the derived haplotypes indicated homogeneity among the populations. Thirty-two individuals with hemoglobinopathies (17 sickle cell disease, 12 HbSC disease and 3 HbCC disease) were also analyzed. The haplotype frequencies of these patients differed significantly from those of the general population. In the sickle cell disease subgroup, the predominant haplotypes were BEN (Benin) and CAR (Central African Republic), with frequencies of 52.9% and 32.4%, respectively. The high frequency of the BEN haplotype agreed with the historical origin of the afro-descendant population in the state of Bahia. However, this frequency differed from that of Salvador, the state capital, where the CAR and BEN haplotypes have similar frequencies, probably as a consequence of domestic slave trade and subsequent internal migrations to other regions of Brazil. PMID:21637405

  11. Land use scenarios development and impacts assessment on vegetation carbon/nitrogen sequestration in the West African Sudan savanna watershed, Benin

    NASA Astrophysics Data System (ADS)

    Chabi, A.

    2015-12-01

    AbstractBackground: Reduced Emissions from Deforestation and Degradation (REDD+), being developed through the United Nations Framework Convention on Climate Change (UNFCCC) requires information on the carbon/nitrogen stocks in the plant biomass for predicting future climate under scenarios development. The development of land use scenarios in West Africa is needed to predict future impacts of change in the environment and the socio-economic status of rural communities. The study aims at developing land use scenario based on mitigation strategy to climate change as an issue of contributing for carbon and nitrogen sequestration, the condition 'food focused' as a scenario based crop production and 'financial investment' as scenario based on an economic development pathway, and to explore the possible future temporal and spatial impacts on vegetation carbon/nitrogen sequestration/emission and socio-economic status of rural communities. Preliminary results: BEN-LUDAS (Benin-Land Use DyNamic Simulator) model, carbon and nitrogen equations, remote sensing and socio-economic data were used to predict the future impacts of each scenario in the environment and human systems. The preliminary results which are under analysis will be presented soon. Conclusion: The proposed BEN-LUDAS models will help to contribute to policy decision making at the local and regional scale and to predict future impacts of change in the environment and socio-economic status of the rural communities. Keywords: Land use scenarios development, BEN-LUDAS, socio-economic status of rural communities, future impacts of change, assessment, West African Sudan savanna watershed, Benin

  12. Real-time science and outreach from the UNOLS fleet via HiSeasNet

    NASA Astrophysics Data System (ADS)

    Foley, S.; Berger, J.; Orcutt, J. A.; Brice, D.; Coleman, D. F.; Grabowski, E. M.

    2010-12-01

    The HiSeasNet satellite communications network has ben providing cost-effective, reliable, continuous Internet connectivity to the UNOLS oceanographic research fleet for nearly nine years. During that time, HiSeasNet has supported science and outreach programs with a variety of real-time interactions back to shore including videoconferencing, webcasting, shared whiteboards, and streaming high-definition video feeds. Solutions have varied in scale, cost, and capability. As real-time science and outreach becomes more common, experience with a variety of technologies continues to build, and more opportunities yet to explore.

  13. [Discussion on sources of texts of Meng Sheng's Herbology of dietotherapy cited in Jinling edition of Compendium of materia medica].

    PubMed

    Shang, Z

    2000-07-01

    Most of the citations of Meng Sheng's Herbology of Dietotherapy in Compendium of Materia Medica are originated from the Daguan Herbology and Zhenghe Herbology. When comparing these sources of citations in Compendium of Materia Medica with the texts in Daguan and Zhenghe, it can be found that there are differences, In Compendium of Materia Medica, it is indicated that these sources marked "Meng Sheng's Herbology of Dietotherapy" are actually derived from other sources, while citations from other sources are marked "Meng Sheng's Herbology of Dietotherapy" which are not found in Classified Herbology (Zhenglei ben cao). This might be due to the editions of Daguan and Zhenghe Li Shizhen applied are different. PMID:11624691

  14. Instabilities and waves in thin films of living fluids

    NASA Astrophysics Data System (ADS)

    Sankararaman, Sumithra; Ramaswamy, Sriram

    2009-03-01

    We formulate the thin-film hydrodynamics of a suspension of polar self-driven particles and show that it is prone to several instabilities through the interplay of activity, polarity and the existence of a free surface. Our approach extends, to self-propelling systems, the work of Ben Amar and Cummings [Phys Fluids 13 (2001) 1160] on thin-film nematics. Based on our estimates the instabilities should be seen in bacterial suspensions and the lamellipodium, and are potentially relevant to the morphology of biofilms. We suggest several experimental tests of our theory.

  15. Instabilities and waves in thin films of living fluids.

    PubMed

    Sankararaman, Sumithra; Ramaswamy, Sriram

    2009-03-20

    We formulate the thin-film hydrodynamics of a suspension of polar self-driven particles and show that it is prone to several instabilities through the interplay of activity, polarity, and the existence of a free surface. Our approach extends, to self-propelling systems, the work of Ben Amar and Cummings [Phys. Fluids 13 1160 (2001)10.1063/1.1359748] on thin-film nematics. Based on our estimates the instabilities should be seen in bacterial suspensions and the lamellipodium, and are potentially relevant to the morphology of biofilms. We suggest several experimental tests of our theory. PMID:19392245

  16. Instabilities and Waves in Thin Films of Living Fluids

    NASA Astrophysics Data System (ADS)

    Sankararaman, Sumithra; Ramaswamy, Sriram

    2009-03-01

    We formulate the thin-film hydrodynamics of a suspension of polar self-driven particles and show that it is prone to several instabilities through the interplay of activity, polarity, and the existence of a free surface. Our approach extends, to self-propelling systems, the work of Ben Amar and Cummings [Phys. FluidsPHFLE61070-6631 13 1160 (2001)10.1063/1.1359748] on thin-film nematics. Based on our estimates the instabilities should be seen in bacterial suspensions and the lamellipodium, and are potentially relevant to the morphology of biofilms. We suggest several experimental tests of our theory.

  17. Talaromyces rubrifaciens, a new species discovered from heating, ventilation and air conditioning systems in China.

    PubMed

    Luo, Yi; Lu, Xiaohong; Bi, Wu; Liu, Fan; Gao, Weiwei

    2016-01-01

    A new Talaromyces species, T. rubrifaciens, was isolated from supply air outlets of heating, ventilation and air conditioning (HVAC) systems in three kinds of public building in Beijing and Nanjing, China. Morphologically it exhibits many characters of section Trachyspermi but is distinguished from other species of this section by restricted growth and broad and strictly biverticillate conidiophores. Phylogenetic analyses based on the internal transcribed spacer rDNA (ITS), β-tubulin (BenA), calmodulin (CaM) and RNA polymerase second largest subunit (RPB2) genes reveal that T. rubrifaciens is a distinct species in section Trachyspermi. PMID:27055570

  18. [Discussion of a medical officer carrying the arm-band of the Red Cross during the second world war].

    PubMed

    Riaud, Xavier

    2008-12-01

    Sacrificing his life to save that of his soldiers and of his nursing staff, Captain Ben Salomon became a legend. Yet, studies of international treaties and of some directives specific to the American Army have seriously held back the historical and public recognition of his heroism. Indeed, when he took hold of the machine gun to cover his men's retreat in 1944, he was wearing a Red Cross armband and was enlisted as a "doctor". What did this mean exactly? Was his action a misdemeanor or definitely an act of heroism? PMID:19579343

  19. Trapping of hydrogen atoms inside small beryllium clusters and their ions

    NASA Astrophysics Data System (ADS)

    Naumkin, F. Y.; Wales, D. J.

    2016-08-01

    Structure, stability and electronic properties are evaluated computationally for small Ben (n = 5-9) cluster cages accommodating atomic H inside and forming core-shell species. These parameters are predicted to vary significantly upon insertion of H, for ionic derivatives, and with the system size. In particular, the energy barrier for H-atom exit from the cage changes significantly for ions compared to the neutral counterparts. The corresponding effects predicted for cage assemblies suggest the possibility of efficient charge-control of hydrogen release. This, together with a high capacity for storing hydrogen in extended such assemblies might indicate a possible way towards feasible hydrogen-storage solutions.

  20. Relaxation of photogenerated carriers in the anatase form of crystalline titanium dioxide

    NASA Astrophysics Data System (ADS)

    Itoh, Chihiro; Wada, Akio

    2005-01-01

    Relaxation of photo-generated carriers in anatase form of crystalline titanium dioxide has ben studied by the photoconductivity measurement. Illumination of anatase crystal with UV light at 300 K has found to induce persistent enhancement in conductivity over 3000 seconds. The magnitude of the induced change is 4000 times greater than that measured in rutile crystal in the same experimental condition. The decay of the persistent photoconductivity after the termination of the UV illumination was characterized by the stretched exponential function. The excitation spectrum measurement revealed that the persistent conductivity characterized by the stretched-exponential relaxation was induced by super-band-gap excitation.

  1. Facility for testing infrared imaging seekers in a countermeasures environment

    NASA Astrophysics Data System (ADS)

    Sidery, Colin J.; Pyle, Andrew

    2001-08-01

    A new Imaging Infrared Countermeasure Hardware-in-the-Loop facility has been designed and built by Matra BAe Dynamics to test imaging sensors in a complex infrared environment. Drawing upon currently available leading edge technologies and UK expertise, the test bed has ben completed in a twelve-month program. The facility comprises a Thermal Picture Synthesizer with up to four further independent channels, each capable of representing a countermeasure (jammer, flare or laser) within the scene. A six stage broadband reflective collimator relays the complex scene to the sensor.

  2. Behavior of adaptive digital erosions

    NASA Astrophysics Data System (ADS)

    Cuciurean-Zapan, Clara; Dougherty, Edward R.; Chen, Yidong

    1996-10-01

    Design of statistically optimal erosion-based filters is problematic due to the complexity of the search process. Specialized search techniques and constraints on optimality are used to mitigate the full search. Adaptation of structuring elements has also ben employed. The present paper looks at the behavior of an adaptive filter relative to the actual optimal filter for a single erosion in two models, signal-union-noise and dilation. It does so in the context of state transitions, where filter states are stacks that determine the structuring element upon thresholding.

  3. Big Bang Day : Physics Rocks

    ScienceCinema

    None

    2011-04-25

    Is particle physics the new rock 'n' roll? The fundamental questions about the nature of the universe that particle physics hopes to answer have attracted the attention of some very high profile and unusual fans. Alan Alda, Ben Miller, Eddie Izzard, Dara O'Briain and John Barrowman all have interests in this branch of physics. Brian Cox - CERN physicist, and former member of 90's band D:Ream, tracks down some very well known celebrity enthusiasts and takes a light-hearted look at why this subject can appeal to all of us.

  4. A robust optimization methodology for preliminary aircraft design

    NASA Astrophysics Data System (ADS)

    Prigent, S.; Maréchal, P.; Rondepierre, A.; Druot, T.; Belleville, M.

    2016-05-01

    This article focuses on a robust optimization of an aircraft preliminary design under operational constraints. According to engineers' know-how, the aircraft preliminary design problem can be modelled as an uncertain optimization problem whose objective (the cost or the fuel consumption) is almost affine, and whose constraints are convex. It is shown that this uncertain optimization problem can be approximated in a conservative manner by an uncertain linear optimization program, which enables the use of the techniques of robust linear programming of Ben-Tal, El Ghaoui, and Nemirovski [Robust Optimization, Princeton University Press, 2009]. This methodology is then applied to two real cases of aircraft design and numerical results are presented.

  5. Nuclear Regulatory Commission issuances, Volume 46, No. 4

    SciTech Connect

    1997-10-01

    This report includes the issuances received in October 1997. Issuances are from the Commission, the Atomic Safety and Licensing Boards, and the Directors` Decisions. Five issuances were received on the following subjects: (1) decontamination and decommissioning funding for Sequoyah Fuels Corporation and General Atomics; (2) involvement in NRC-licensed activities by Aharon Ben-Haim; (3) Barnett Industrial X-Ray, Inc.; (4) spent fuel storage installation at Northern States Power Company; and (5) Vermont Yankee Nuclear Power Station. No issuances were received from the the Administrative Law Judges or the Decisions on Petitions for Rulemaking.

  6. Big Bang Day : Physics Rocks

    SciTech Connect

    2009-10-07

    Is particle physics the new rock 'n' roll? The fundamental questions about the nature of the universe that particle physics hopes to answer have attracted the attention of some very high profile and unusual fans. Alan Alda, Ben Miller, Eddie Izzard, Dara O'Briain and John Barrowman all have interests in this branch of physics. Brian Cox - CERN physicist, and former member of 90's band D:Ream, tracks down some very well known celebrity enthusiasts and takes a light-hearted look at why this subject can appeal to all of us.

  7. Metals and kidney markers in adult offspring of endemic nephropathy patients and controls: a two-year follow-up study

    PubMed Central

    Karmaus, Wilfried; Dimitrov, Plamen; Simeonov, Valeri; Tsolova, Svetla; Bonev, Angel; Georgieva, Rossitza

    2008-01-01

    Background The etiology of Balkan Endemic Nephropathy, (BEN), a tubulointerstitial kidney disease, is unknown. Although this disease is endemic in rural areas of Bosnia, Bulgaria, Croatia, Romania, and Serbia, similar manifestations are reported to occur in other regions, for instance Tunisia and Sri Lanka. A number of explanations have been stated including lignites, aristolochic acid, ochratoxin A, metals, and metalloids. Etiologic claims are often based on one or a few studies without sound scientific evidence. In this systematic study, we tested whether exposures to metals (cadmium and lead) and metalloids (arsenic and selenium) are related to Balkan Endemic Nephropathy. Methods In 2003/04 we recruited 102 adults whose parents had BEN and who resided in one of three communities (Vratza, Bistretz, or Beli Izvor, Bulgaria). A control group comprised of 99 adults having non-BEN hospitalized parents was enrolled in the study during the same time. We conducted face-to-face interviews, ultrasound kidney measurements, and determined kidney function in two consecutive investigations (2003/04 and 2004/05). Metals and metalloids were measured in urine and blood samples. To assess the agreement between these consecutive measurements, we calculated intraclass correlation coefficients. Repeated measurement data were analyzed using mixed models. Results We found that cadmium and arsenic were associated with neither kidney size nor function. Lead had a significant but negligible effect on creatinine clearance. Selenium showed a weak but significant negative association with two of the four kidney parameters, namely creatinine clearance and β2-microglobulin. It was positively related to kidney length. These associations were not restricted to the offspring of BEN patients. Adding credence to these findings are reports showing comparable kidney effects in animals exposed to selenium. Conclusion The findings of this 2-year follow-up study indicate that metals and metalloids do

  8. [Herbal textual research on origin and development of traditional Chinese medicine "duhuo" and "qianghuo"].

    PubMed

    Shan, Feng; Yuan, Yuan; Hao, Jin-Da; Huang, Lu-Qi

    2014-09-01

    To clarify the origin and development of the traditional Chinese medicine "Duhuo" and "Qianghuo" with medicinal literatures. Medical literatures of past dynasties were analysed and combined with the modern material. The "Duhuo" in Herbal writing Shen Nong Ben Cao Jing include traditional Chinese medicine "Duhuo" and "Qianghuo", "Qianghuo" was separated from "Duhuo" due to the distinguish of clinical application. The origin of "Qianghuo" is Notopterygium incisum and N. forbesii, However, The origin of "Duhuo" is very complex, Angelica pubescens f. biserrata as authentic "Duhuo" was used from Song Dynasty. "Qianghuo" was originated from "Duhuo". PMID:25522638

  9. Seamounts and ferromanganese crusts within and near the U.S. EEZ off California - Data for RV Farnella cruise F7-87-SC

    USGS Publications Warehouse

    Hein, James R.; Reid, Jane A.; Conrad, Tracey A.; Dunham, Rachel E.; Clague, David A.; Schulz, Marjorie S.; Davis, Alice S.

    2010-01-01

    The purpose of this report is to present and briefly describe ship-board and laboratory data for a U.S. Geological Survey (USGS) research cruise aboard the RV Farnella that took place December 3-21, 1987 (cruise F7-87-SC). The purpose of the cruise was to survey seamounts and ferromanganese crusts within and near the U.S. Exclusive Economic Zone (EEZ) off California. Eight seamounts were studied - Rodriguez, San Marcos, Adam, Hoss, Little Joe, Ben, Flint, and Jasper. A geophysical survey of Jasper Seamount took place, but that seamount was not sampled; whereas Adam and Hoss Seamounts were sampled, but not surveyed with geophysics lines.

  10. The Top 10 Reasons Children With Autism Deserve ABA

    PubMed Central

    Walsh, Mary Beth

    2011-01-01

    We who advocate for applied behavior analysis (ABA) for children with autism spectrum disorders often construct our arguments based on the scientific evidence. However, the audience that most needs to hear this argument, that is, the parents of children, especially very young children, diagnosed with autism, may not be convinced by the science alone. This essay attempts to make the case for the multiple benefits of ABA intervention through the use of humor and anecdotes couched in a “Top Ten List,” and illustrating most points with stories of an engaging child with autism (my son, Ben). PMID:22532906

  11. Geomorphological evolution of a newly restored upland temporary stream

    NASA Astrophysics Data System (ADS)

    Marteau, Baptiste; Batalla, Ramon J.; Gibbins, Chris N.; Green, David R.; Vericat, Damià

    2015-04-01

    The river Ehen, NW England, has been designated as a Special Area of Conservation (SAC) as it hosts England's largest population of freshwater pearl mussels (M. margaritifera). One of the Ehen's main headwater tributary, Ben Gill, was diverted to Ennerdale Lake in the 1970s to help increase the volume of water available for abstraction. Concerns over this diversion on the hydrology and sediment dynamics of the Ehen has led to the reconnection of this temporary stream as part of a project designed to improve habitat conditions for mussels in the Ehen. The reconnection has involved the construction of a new section of channel, following the natural (pre-diversion) course of Ben Gill. This paper presents findings of research designed to track the morphological evolution of the newly created Ben Gill channel. The work follows a previous research in which fluvial dynamics in the Ehen were studied before the reconnection of Ben Gill. Morpho-sedimentary dynamics are analysed at multiple scales: from the movement of individual particles, to changes on channel morphology following competent flow events. Changes in the channel's grain size distributions have been investigated in different sections, while bed mobility has been assessed using a combination of radio frequency identification (RFID) tags inserted into representative particles and painted bed patches. Additionally, digital elevation models (DEMs) of the entire new channel have been constructed by means of automatic digital photogrammetry using high resolution aerial photography taken by an unmanned aerial vehicle (UAV). DEMs of difference (DoD) between major flow events have been used to track lateral and longitudinal changes in the channel at a spatial resolution of less than 5cm. Finally, in order to link sedimentological changes in the new channel to its impact on the main stem Ehen, morpho-sedimentary changes of a gravel bar at the confluence have been monitored combining tracers (i.e. RFID) and repeated

  12. Scattering of {sup 11}Be Around the Coulomb barrier

    SciTech Connect

    Acosta, L.; Martel, I.; Perez-Bernal, F.; Sanchez-Benitez, A. M.; Alvarez, M. A. G.; Gomez-Camacho, J.; Andres, M. V.; Espino, J. M.; Moro, A. M.; Mukha, I.; Borge, M. J. G.; Cortes, M.; Galaviz, D.; Maira, A.; Reillo, E.; Tengblad, O.; Rusek, K.

    2009-08-26

    Preliminary results on the {sup 11}Be+{sup 120}Sn quasielastic scattering as well as the {sup 11}Be{yields}{sup 10}Be+n breakup channel are presented in this work. The angular distributions of these channels were measured at REX-ISOLDE-CERN. The accuracy and angular range of the presented results provide stronger constrains to the theoretical interpretation than existing published results. We compare these new data with coupled-channel (CC) and continuum-discretized coupled-channel (CDCC) calculations. The role played by transfer and breakup channels in the elastic scattering is discussed.

  13. Simple models for intermittent deformation and slip avalanches: from crystals to granular materials and earthquakes

    NASA Astrophysics Data System (ADS)

    Dahmen, K.; Ben-Zion, Y.; Uhl, J.

    2011-12-01

    Slowly sheared solid or densely packed granular materials often deform in an intermittent way with slip avalanches. The distribution of sizes follows often a power law over a broad range of sizes. In these cases, universal (i.e. detail-independent) scaling behavior governs the statistics of the slip-avalanches. Under some conditions, there are also "characteristic" statistics associated with enhanced occurrence of system-size events, and long-term mode switching between power law and characteristic behavior. These dynamic regimes can be understood with basic micromechanical model for deformation of solids with only two tuning parameter: weakening and dissipation of elastic stress transfer. For granular materials the packing fraction plays the role of the dissipation parameter and it sets the size of the largest slip avalanche. The model can reproduce observed stress-strain curves, power spectra of acoustic emissions, statistics of slip avalanches, and geometrical properties of slip, with a continuous phase transition from brittle to ductile behavior. Exact universal predictions for the power law exponents of the avalanche size distributions, durations, power spectra of acoustic emissions, and scaling functions are extracted using an analytical mean field theory and renormalization group tools. For granular materials a dynamic phase diagram with solid-like behavior and large slip avalanches at large packing fractions, and fluid-like behavior at lower packing fractions is obtained. The results agree with recent experimental observations and simulations of the statistics of dislocation dynamics in sheared crystals such as ice [1], slip avalanches in sheared granular materials [2], and avalanches in magnetic and fault systems [3,4]. [1] K. A. Dahmen, Y. Ben-Zion, and J.T. Uhl, "A micromechanical model for deformation in solids with universal predictions for stress strain curves and slip avalanches", Physical Review Letters 102, 175501/1-4 (2009). [2] K. A. Dahmen, Y

  14. Sandsturm kontra Wassersturm: Physik im Alltag

    NASA Astrophysics Data System (ADS)

    Müller, Andreas

    2006-07-01

    Sandstürme ereignen sich oft, Wasserstürme hingegen so gut wie nie. Eine Abschätzung zeigt, dass man beim Herauslösen eines Wassertropfens beispielsweise aus dem Meer eine sehr große Kraft benötigt und sehr viel Arbeit verrichten muss. Das scheint die Erklärung zu sein. Führt man eine entsprechende Energiebetrachtung durch, so könnte es durchaus Wasserstürme geben. Diese Überlegung ist zwar mathematisch richtig, aber unvollständig.

  15. Hygroscopicity Evaluation of Halide Scintillators

    SciTech Connect

    Zhuravleva, M; Stand, L; Wei, H; Hobbs, C. L.; Boatner, Lynn A; Ramey, Joanne Oxendine; Burger, Arnold; Rowe, E; Bhattacharya, P.; Tupitsyn, E; Melcher, Charles L

    2014-01-01

    A collaborative study of relative hygroscopicity of anhydrous halide scintillators grown at various laboratories is presented. We have developed a technique to evaluate moisture sensitivity of both raw materials and grown crystals, in which the moisture absorption rate is measured using a gravimetric analysis. Degradation of the scintillation performance was investigated by recording gamma-ray spectra and monitoring the photopeak position, count rate and energy resolution. The accompanying physical degradation of the samples exposed to ambient atmosphere was photographically recorded as well. The results were compared with ben

  16. Vom magnetischen Bakterium zur Brieftaube: Geo-Biomagnetismus

    NASA Astrophysics Data System (ADS)

    Winklhofer, Michael

    2004-05-01

    Die Fähigkeit, das Erdmagnetfeld wahrzunehmen und sich an ihm zu orientieren, ist im Tierreich weit verbreitet. Durch welche physikalischen Mechanismen magnetische Sinnesreize in Nervensignale umgesetzt werden, ist jedoch weitgehend ungeklärt. Bei magnetotaktischen Bakterien üben zum Beispiel biogene ferrimagnetische Kristalle als mikroskopische Kompassnadeln ein Drehmoment auf die Zelle aus. Magnetit findet sich im Gewebe zahlreicher Tiere. Doch erst bei zwei Arten, der Brieftaube und der Regenbogenforelle, konnten auch entsprechende Sinneszellen gefunden werden. Diese unterscheiden sich allerdings in ihren magnetischen Eigenschaften fundamental voneinander. Die Identifizierung der physikalischen Mechanismen des Geo-Biomagnetismus bleibt eine Herausforderung für Biophysik und Sinnesphysiologie.

  17. Talking about Life

    NASA Astrophysics Data System (ADS)

    Impey, Chris

    2010-08-01

    Preface; Part I. Introduction Timothy Ferris, Iris Fry, Steven Dick, Ann Druyan, Pinky Nelson, Neil Tyson, Steve Benner and William Bains; Part II. Earth Roger Buick, Lynn Rothschild, John Baross, Joe Kirschvink, Andrew Knoll, Simon Conway Morris, Roger Hanlon and Lori Marino; Part III. Solar System Chris McKay, David Grinspoon, Jonathan Lunine, Carolyn Porco, Laurie Leshin, Guy Consolmagno and Peter Smith; Part IV. Exoplanets Alan Boss, Geoff Marcy, Debra Fischer, Sara Seager, David Charbonneau and Vikki Meadows; Part V. Frontiers Jill Tarter, Seth Shostak, Ray Kurzweil, Nick Bostrom, Paul Davies, Martin Rees, Ben Bova and Jennifer Michael Hecht; Reading list; Glossary; Index.

  18. Study of the 10B(p,α)7Be Reaction through the Indirect Trojan Horse Method

    NASA Astrophysics Data System (ADS)

    Puglia, S. M. R.; Romano, S.; Del Santo, M. G.; Lamia, L.; Spitaleri, C.; Carlin, N.; Cherubini, S.; Gulino, M.; Kroha, V.; Kubono, S.; La Cognata, M.; Li, C.; Pizzone, R. G.; Qungang, W.; Rapisarda, G. G.; Sergi, M. L.; Somoryai, E.; Souza, F.; Szanto de Toledo, A.; Tudisco, S.; Tumino, A.; Wakabayashi, Y.; Yamaguchi, H.

    2010-03-01

    The 10B(p,α)7Be reaction is the main responsible for 10B destruction in stellar interior. In such environments the process takes places mainly through a resonant state of the compound 11C nucleus. The 10B(p,α)7Be reaction has been studied by means of the Trojan Horse Method using the 2H(10B,α7Be)n three-body reaction. The experiment was performed at the Laboratori Nazionali del Sud in Catania. The 10B(p,α)7Be reaction cross section has been extracted at low neutron momentum.

  19. Discovery and classification of 17 new supernovae by the Palomar Transient Factory

    NASA Astrophysics Data System (ADS)

    Ben-Ami, S.; Badenes, C.; Kulkarni, S. R.; Matheson, T.; Xu, D.; Gal-Yam, A.; Arcavi, I.; Kasliwal, M. M.; Quimby, R.; Yaron, O.; Stenberg, A.; Green, Y.; Nugent, P. E.; Howell, D. A.; Sullivan, M.; Cooke, J.; Cenko, S. B.; Law, N.; Levitan, D.; Ofek, E. O.; Poznanski, D.; Palomar Transient Factory

    2010-10-01

    We report the discovery and spectroscopic classification of 17 new supernovae from the Palomar Transient Factory (PTF; http://www.astro.caltech.edu/ptf ). The supernovae were discovered and classified by Oarical, an autonomous software framework of the PTF collaboration, based on observations made with the Palomar 48-inch Oschin Schmidt telescope. Spectroscopy was undertaken with the R-C spectrograph mounted at the Cassegrain focus of the Mayall 4-m telescope at Kitt Peak Observatory on UT 2010 October 8-10 by Ben- Ami, Badenes, Kulkarni, and Matheson.

  20. An Analysis of Health Impacts Associated with Pollutant Response to Changes in Emissions In Different Regions of Central California

    NASA Astrophysics Data System (ADS)

    Tran, C.; Tanrikulu, S.; Beaver, S.; Hilken, H.

    2011-12-01

    Exposure to ozone and particulate matter has been shown to have considerable human health impacts. Currently major air basins of central California such as the San Francisco Bay Area (SFBA), Sacramento area, and the San Joaquin Valley (SJV) are all designated as in nonattainment of the Federal 8-hour ozone and 24-hour PM2.5 standards, despite California's comprehensive emission control programs for the last fifty years. Although these programs were very effective, decreasing anthropogenic emissions 40 to 50 percent in the region from 1990 to 2010 alone, the ambient response of pollutants was mixed and varied among these three interconnected regions. The purpose of this work was to investigate differences in each region's human health impact response to changes in emissions using the US EPA's BenMAP program. Inputs to BenMAP were prepared using the CMAQ model. Ambient concentrations were simulated for 2005. Then, anthropogenic emissions were reduced 10 to 60 percent across the board in 10 percent increments for the purpose of assessing pollutant responses to changes in emissions. BenMAP was run for each emission reduction scenario. The BenMAP results were normalized by county population to enable comparisons among counties that ranged from rural and agricultural to urban and densely populated. In all regions, the benefits of direct PM emission reductions were greater than those of similar precursor reductions. With respect to mortality rates, direct PM reductions produced the largest benefits in Nevada, Stanislaus, Tuolumne, and San Francisco Counties. For a 40 percent reduction in emissions, reductions in annual mortality rates ranged from 120 to 140 per million for these counties. Precursor emission reductions' benefits were maximized at the southern end of SJV, with Tulare showing the maximum reduction of around 83 mortalities per million. Monetized benefits of avoided mortalities as a result of direct PM emission reductions were significantly higher in

  1. No-Reflow Phoenomenon by Intracoronary Thrombus in Acute Myocardial Infarction

    PubMed Central

    2016-01-01

    Recently, percutaneous coronary intervention has been the treatment of choice in most acute myocardial infarction cases. Although the results of percutaneous coronary interventions have ben good, the no-reflow phenomenon and distal embolization of intracoronary thrombus are still major problems even after successful interventions. In this article, we will briefly review the deleterious effects of no-reflow and distal embolization of intracoronary thrombus during percutaneous coronary interventions. The current trials focused on the prevention and treatment of the no-reflow phenomenon and intracoronary thrombus. PMID:26865998

  2. Isolation, characterization, and expression of a second {beta}-tubulin-encoding gene from Colletotrichum gloeosporioides f. sp. aeschynomene

    SciTech Connect

    Buhr, T.L.; Dickman, M.B.

    1994-11-01

    Colletotrichum gloeosporioides (Penz.) Sacc. F. sp. aeschynomene incites anthracnose on Aeschynomene virgininica (northern jointvetch). Northern jointvetch is a leguminous weed in rice and soybean fields. Contaminating northern jointvetch seeds greatly reduce the market value of rice. C. gloeosporioides (Penz.) Sacc. F. sp. aeschynomene has been commercially marketed as a mycoherbicide to decrease populations of northern jointvetch. Development of a transformation system would be extremely useful for investigating the molecular biology of C. gloeosporioides (Penz.) Sacc. F. sp. aeschynomen. This paper reports the nucleotide sequence of a second gene for {beta} Tub (TUB2) in C. gloeosporioides (Penz.) Sacc. F. sp. aeschynomene and identifies a molecular lesion which likely confers BEN (systemic fungicide) resistance.

  3. TU-A-17A-01: Memorial to Benjamin M. Galkin - Memorial Lecture

    SciTech Connect

    Suntharalingam, N

    2014-06-15

    This past year Medical Physics lost one of its active members, Benjamin M. Galkin. Ben Galkin was a Past-Treasurer of the AAPM. During his leadership role he played an important part in Securing membership, for the AAPM, in the American Institute of physics. As Treasurer he was also a prime mover in starting the journal, Medical Physics, and served as its business manager in the formative years.Ben Galkin received his Masters Degree at Columbia University in New York, under the mentorship of Dr. Edith Quimby, one of the pioneer Hospital Radiation Physicists in the country. He started his professional career at Jefferson Hospital in Philadelphia, joining Robert Gorson, and remained there until retirement. He served as the institution’s Radiation Safety Officer throughout his career. His research interest was Breast Imaging. He held joint faculty appointments in the Department of Radiology and the Department of Radiation Therapy and Nuclear Medicine, rising up to the rank of Full professor. He was a well respected teacher for the residents in Radiology.

  4. Group I Paks as therapeutic targets in NF2-deficient meningioma

    PubMed Central

    Duron, Sergio G.; Campbell, David A.; Ong, Christy C.; Hoeflich, Klaus P.; Chang, Long-Sheng; Welling, D. Bradley; Yang, Zeng-jie; Chernoff, Jonathan

    2015-01-01

    Neurofibromatosis type 2 (NF2) is an autosomal dominant disorder characterized by the development of multiple tumors in the central nervous system, most notably schwannomas and meningiomas. Mutational inactivation of NF2 is found in 40–60% of sporadic meningiomas, but the molecular mechanisms underlying malignant changes of meningioma cells remain unclear. Because group I p21-activated kinases (Paks) bind to and are inhibited by the NF2-encoded protein Merlin, we assessed the signaling and anti-tumor effects of three group-I specific Pak inhibitors - Frax597, 716 and 1036 - in NF2−/− meningiomas in vitro and in an orthotopic mouse model. We found that these Pak inhibitors suppressed the proliferation and motility of both benign (Ben-Men1) and malignant (KT21-MG1) meningiomas cells. In addition, we found a strong reduction in phosphorylation of Mek and S6, and decreased cyclin D1 expression in both cell lines after treatment with Pak inhibitors. Using intracranial xenografts of luciferase-expressing KT21-MG1 cells, we found that treated mice showed significant tumor suppression for all three Pak inhibitors. Similar effects were observed in Ben-Men1 cells. Tumors dissected from treated animals exhibited an increase in apoptosis without notable change in proliferation. Collectively, these results suggest that Pak inhibitors might be useful agents in treating NF2-deficient meningiomas. PMID:25596744

  5. BEND3 represses rDNA transcription by stabilizing a NoRC component via USP21 deubiquitinase

    PubMed Central

    Khan, Abid; Giri, Sumanprava; Wang, Yating; Chakraborty, Arindam; Ghosh, Archit K.; Anantharaman, Aparna; Aggarwal, Vasudha; Sathyan, Kizhakke M.; Ha, Taekjip; Prasanth, Kannanganattu V.; Prasanth, Supriya G.

    2015-01-01

    Ribosome biogenesis dictates the translational capacity of cells. Several mechanisms establish and maintain transcriptional output from eukaryotic ribosomal DNA (rDNA) loci. rDNA silencing is one such mechanism that ensures the inactivity and hence the maintenance of a silenced state of a subset of rRNA gene copies. Whereas oncogenic agents stimulate rRNA gene transcription, tumor suppressors decrease rRNA gene transcription. We demonstrate in mammalian cells that BANP, E5R, and Nac1 (BEN) domain 3 (BEND3), a quadruple BEN domain-containing protein, localizes in nucleoli and binds to ribosomal RNA gene promoters to help repress rRNA genes. Loss of BEND3 increases histone H3K4 trimethylation and, correspondingly, decreases rDNA promoter DNA methylation, consistent with a role for BEND3 in rDNA silencing. BEND3 associates with the nucleolar-remodeling complex (NoRC), and SUMOylated BEND3 stabilizes NoRC component TTF-1–interacting protein 5 via association with ubiquitin specific protease 21 (USP21) debiquitinase. Our results provide mechanistic insights into how the novel rDNA transcription repressor BEND3 acts together with NoRC to actively coordinate the establishment of rDNA silencing. PMID:26100909

  6. BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells

    PubMed Central

    Dai, Qi; Andreu-Agullo, Celia; Insolera, Ryan; Wong, Li Chin; Shi, Song-Hai; Lai, Eric C.

    2013-01-01

    The activity of the Notch pathway revolves around a CSL-class transcription factor, which recruits distinct complexes that activate or repress target gene expression. The co-activator complex is deeply conserved and includes the cleaved Notch intracellular domain (NICD) and Mastermind. By contrast, numerous CSL co-repressor proteins have been identified, and these are mostly different between invertebrate and vertebrate systems. In this study, we demonstrate that mammalian BEND6 is a neural BEN-solo factor that shares many functional attributes with Drosophila Insensitive, a co-repressor for the Drosophila CSL factor. BEND6 binds the mammalian CSL protein CBF1 and antagonizes Notch-dependent target activation. In addition, its association with Notch- and CBF1-regulated enhancers is promoted by CBF1 and antagonized by activated Notch. In utero electroporation experiments showed that ectopic BEND6 inhibited Notch-mediated self-renewal of neocortical neural stem cells and promoted neurogenesis. Conversely, knockdown of BEND6 increased NSC self-renewal in wild-type neocortex, and exhibited genetic interactions with gain and loss of Notch pathway activity. We recapitulated all of these findings in cultured neurospheres, in which overexpression and depletion of BEND6 caused reciprocal effects on neural stem cell renewal and neurogenesis. These data reveal a novel mammalian CSL co-repressor in the nervous system, and show that the Notch-inhibitory activity of certain BEN-solo proteins is conserved between flies and mammals. PMID:23571214

  7. BEND3 represses rDNA transcription by stabilizing a NoRC component via USP21 deubiquitinase.

    PubMed

    Khan, Abid; Giri, Sumanprava; Wang, Yating; Chakraborty, Arindam; Ghosh, Archit K; Anantharaman, Aparna; Aggarwal, Vasudha; Sathyan, Kizhakke M; Ha, Taekjip; Prasanth, Kannanganattu V; Prasanth, Supriya G

    2015-07-01

    Ribosome biogenesis dictates the translational capacity of cells. Several mechanisms establish and maintain transcriptional output from eukaryotic ribosomal DNA (rDNA) loci. rDNA silencing is one such mechanism that ensures the inactivity and hence the maintenance of a silenced state of a subset of rRNA gene copies. Whereas oncogenic agents stimulate rRNA gene transcription, tumor suppressors decrease rRNA gene transcription. We demonstrate in mammalian cells that BANP, E5R, and Nac1 (BEN) domain 3 (BEND3), a quadruple BEN domain-containing protein, localizes in nucleoli and binds to ribosomal RNA gene promoters to help repress rRNA genes. Loss of BEND3 increases histone H3K4 trimethylation and, correspondingly, decreases rDNA promoter DNA methylation, consistent with a role for BEND3 in rDNA silencing. BEND3 associates with the nucleolar-remodeling complex (NoRC), and SUMOylated BEND3 stabilizes NoRC component TTF-1-interacting protein 5 via association with ubiquitin specific protease 21 (USP21) debiquitinase. Our results provide mechanistic insights into how the novel rDNA transcription repressor BEND3 acts together with NoRC to actively coordinate the establishment of rDNA silencing. PMID:26100909

  8. High and low frequency instabilities driven by counter-streaming electron beams in space plasmas

    SciTech Connect

    Mbuli, L. N.; Maharaj, S. K.; Bharuthram, R.

    2014-05-15

    A four-component plasma composed of a drifting (parallel to ambient magnetic field) population of warm electrons, drifting (anti-parallel to ambient magnetic field) cool electrons, stationary hot electrons, and thermal ions is studied in an attempt to further our understanding of the excitation mechanisms of broadband electrostatic noise (BEN) in the Earth's magnetospheric regions such as the magnetosheath, plasmasphere, and plasma sheet boundary layer (PSBL). Using kinetic theory, beam-driven electrostatic instabilities such as the ion-acoustic, electron-acoustic instabilities are found to be supported in our multi-component model. The dependence of the instability growth rates and real frequencies on various plasma parameters such as beam speed, number density, temperature, and temperature anisotropy of the counter-streaming (relative to ambient magnetic field) cool electron beam are investigated. It is found that the number density of the anti-field aligned cool electron beam and drift speed play a central role in determining which instability is excited. Using plasma parameters which are closely correlated with the measurements made by the Cluster satellites in the PSBL region, we find that the electron-acoustic and ion-acoustic instabilities could account for the generation of BEN in this region.

  9. Does Discourse Congruence Influence Spoken Language Comprehension before Lexical Association? Evidence from Event-Related Potentials

    PubMed Central

    Boudewyn, Megan A.; Gordon, Peter C.; Long, Debra; Polse, Lara; Swaab, Tamara Y.

    2011-01-01

    The goal of this study was to examine how lexical association and discourse congruence affect the time course of processing incoming words in spoken discourse. In an ERP norming study, we presented prime-target pairs in the absence of a sentence context to obtain a baseline measure of lexical priming. We observed a typical N400 effect when participants heard critical associated and unassociated target words in word pairs. In a subsequent experiment, we presented the same word pairs in spoken discourse contexts. Target words were always consistent with the local sentence context, but were congruent or not with the global discourse (e.g., “Luckily Ben had picked up some salt and pepper/basil”, preceded by a context in which Ben was preparing marinara sauce (congruent) or dealing with an icy walkway (incongruent). ERP effects of global discourse congruence preceded those of local lexical association, suggesting an early influence of the global discourse representation on lexical processing, even in locally congruent contexts. Furthermore, effects of lexical association occurred earlier in the congruent than incongruent condition. These results differ from those that have been obtained in studies of reading, suggesting that the effects may be unique to spoken word recognition. PMID:23002319

  10. East with the night: longitudinal migration of the Orinoco goose (Neochen jubata) between Manú National Park, Peru and the Llanos de Moxos, Bolivia.

    PubMed

    Davenport, Lisa C; Nole Bazán, Inés; Carlos Erazo, Nancy

    2012-01-01

    We report on the intra-Amazonian migration of a pair of Orinoco Geese (Neochen jubata) from Manú National Park, Peru. The species is Critically Endangered in Peru, so a major aim of the study was to aid conservation planning by learning the wet season location of the country's last known breeding population. We captured a breeding pair on October 27, 2010, and fitted the birds with Microwave Telemetry, Inc. GPS/Argos satellite PTT's. The pair migrated ∼655 km from Manú National Park to the Llanos de Moxos, Bolivia (Dept. of Bení) in a predominantly longitudinal migration, reaching their final destination on December 23, 2010. Major movements (>5 km per time period) were almost exclusively at night and were undertaken with and without moonlight. Foraging areas used at stopovers in the Llanos de Moxos were remarkably limited, suggesting the importance of grazing lawns maintained by the geese and other herbivores, possibly including cattle. Orinoco Geese are resident in the Llanos de Moxos year-round, so the Manú geese represent a partial migration from the Bení region. We hypothesize that cavity nest limitation explains the partial migration of Orinoco Geese from the Llanos de Moxos. PMID:23056512

  11. Correlations and Synchronization in Earthquake Physics (Invited)

    NASA Astrophysics Data System (ADS)

    Rundle, J. B.; Gran, J. D.; Holliday, J. R.; Turcotte, D. L.; Klein, W.; Tiampo, K. F.

    2009-12-01

    Synchronization in earthquake physics has been observed for many years, both in the tendency for earthquakes to cluster in space and time, and by virtue of the fact that, through elastic interactions, areas on a fault that begin to slip induce their neighbor locations to slip in a growing avalanche of failing sites. A similar dynamics has been observed for many years in neural networks by Abeles and others, but it was not until the mid 1990’s that Hopfield and collaborators were able to model this effect by means of an earthquake-type slider block model. In fact, Hopfield used the threshold properties of neon light bulbs to build a laboratory demonstration of an interacting synchronous network of bulbs using the same physics, an electrical analog of the mechanical spring slider system. Hopfield was also able to show that subtle differences in the block failure algorithm led to a Lyapunov exponent that drove the network of sliding blocks toward periodic limit cycles. Other methods of producing periodic, or “characteristic earthquake” behavior in slider block systems have been discussed by Ben-Zion et al, and more recently by Gran et al. In the Ben-Zion model, incomplete healing of blocks during sliding events leads to large periodic earthquakes for values of healing parameter below a critical point. This critical point appears to be characterized by the same scaling exponents as are observed for mean field site percolation on a Bethe lattice.

  12. Rethinking historical and cultural source of spontaneous mental models of water cycle: in the perspective of South Korea

    NASA Astrophysics Data System (ADS)

    Nam, Younkyeong

    2012-06-01

    This review explores Ben-Zvi Assaraf, Eshach, Orion, and Alamour's paper titled "Cultural Differences and Students' Spontaneous Models of the Water Cycle: A Case Study of Jewish and Bedouin Children in Israel" by examining how the authors use the concept of spontaneous mental models to explain cultural knowledge source of Bedouin children's mental model of water compared to Jewish children's mental model of water in nature. My response to Ben-Zvi Assaraf et al.'s work expands upon their explanations of the Bedouin children's cultural knowledge source. Bedouin children's mental model is based on their culture, religion, place of living and everyday life practices related to water. I suggest a different knowledge source for spontaneous mental model of water in nature based on unique history and traditions of South Korea where people think of water in nature in different ways. This forum also addresses how western science dominates South Korean science curriculum and ways of assessing students' conceptual understanding of scientific concepts. Additionally I argue that western science curriculum models could diminish Korean students' understanding of natural world which are based on Korean cultural ways of thinking about the natural world. Finally, I also suggest two different ways of considering this unique knowledge source for a more culturally relevant teaching Earth system education.

  13. DISCOVERY OF A DARK AURORAL OVAL ON SATURN

    NASA Technical Reports Server (NTRS)

    2002-01-01

    The ultraviolet image was obtained by the NASA/ESA Hubble Space Telescope with the European Faint Object Camera (FOC) on June 1992. It represents the sunlight reflected by the planet in the near UV (220 nm). * The image reveals a dark oval encircling the north magnetic pole of Saturn. This auroral oval is the first ever observed for Saturn, and its darkness is unique in the solar system (L. Ben-Jaffel, V. Leers, B. Sandel, Science, Vol. 269, p. 951, August 18, 1995). The structure represents an excess of absorption of the sunlight at 220 nm by atmospheric particles that are the product of the auroral activity itself. The large tilt of the northern pole of Saturn at the time of observation, and the almost perfect symmetry of the planet's magnetic field, made this observation unique as even the far side of the dark oval across the pole is visible! * Auroral activity is usually characterized by light emitted around the poles. The dark oval observed for Saturn is a STUNNING VISUAL PROOF that transport of energy and charged particles from the magnetosphere to the atmosphere of the planet at high latitudes induces an auroral activity that not only produces auroral LIGHT but also UV-DARK material near the poles: auroral electrons are probably initiating hydrocarbon polymer formation in these regions. Credits: L. Ben Jaffel, Institut d'Astrophysique de Paris-CNRS, France, B. Sandel (Univ. of Arizona), NASA/ESA, and Science (magazine).

  14. East with the Night: Longitudinal Migration of the Orinoco Goose (Neochen jubata) between Manú National Park, Peru and the Llanos de Moxos, Bolivia

    PubMed Central

    Davenport, Lisa C.; Nole Bazán, Inés; Carlos Erazo, Nancy

    2012-01-01

    We report on the intra-Amazonian migration of a pair of Orinoco Geese (Neochen jubata) from Manú National Park, Peru. The species is Critically Endangered in Peru, so a major aim of the study was to aid conservation planning by learning the wet season location of the country's last known breeding population. We captured a breeding pair on October 27, 2010, and fitted the birds with Microwave Telemetry, Inc. GPS/Argos satellite PTT's. The pair migrated ∼655 km from Manú National Park to the Llanos de Moxos, Bolivia (Dept. of Bení) in a predominantly longitudinal migration, reaching their final destination on December 23, 2010. Major movements (>5 km per time period) were almost exclusively at night and were undertaken with and without moonlight. Foraging areas used at stopovers in the Llanos de Moxos were remarkably limited, suggesting the importance of grazing lawns maintained by the geese and other herbivores, possibly including cattle. Orinoco Geese are resident in the Llanos de Moxos year-round, so the Manú geese represent a partial migration from the Bení region. We hypothesize that cavity nest limitation explains the partial migration of Orinoco Geese from the Llanos de Moxos. PMID:23056512

  15. [Folk memory of Baosheng Dadi].

    PubMed

    Li, Chunxing

    2011-07-01

    In Fujian and Taiwan, there are a lot of temples dedicated to Baosheng Dadi (Life Blessing Emperor), who was named WU Ben (courtesy name as Huaji and pseudonym as Xuedong). He was born in the fourth year of the Taipingxingguo Period (979) and died in the third year of the Jingyou Period (1036) in the Northern Song Dynasty. He was clever and rich in knowledge when he was a child. He decided to be a doctor after his father and mother's death at early ages. WU Ben passed the imperial examinations at the provincial level when he was 24 years old and was appointed as supervising censor. Several years later, he resigned and began to cultivate himself according to doctrine of Taoism in Mount Dayan, Baijiao Village, Quanzhou District. Meanwhile, he studied Traditional Chinese Medicine in his spare time and helped patients. After his death, people called him Medical Sage out of respect and memory and built temples dedicated to him. After that, emperors in many dynasties had conferred him. The Emperor Song-ren-zong conferred him as Baosheng Dadi and rewarded him with the dragon robe. Local officials are requested to sacrifice to him in spring and autumn every year. From then on, Baosheng Dadi became a highly skilled doctor in folk belief. PMID:22169495

  16. Field experiments using SPEAR: a speech control system for UGVs

    NASA Astrophysics Data System (ADS)

    Chhatpar, Siddharth R.; Blanco, Chris; Czerniak, Jeffrey; Hoffman, Orin; Juneja, Amit; Pruthi, Tarun; Liu, Dongqing; Karlsen, Robert; Brown, Jonathan

    2009-05-01

    This paper reports on a Field Experiment carried out by the Human Research and Engineering Directorate at Ft. Benning to evaluate the efficacy of using speech to control an Unmanned Ground Vehicle (UGV) concurrently with a handcontroller. The SPEAR system, developed by Think-A-Move, provides speech-control of UGVs. The system picks up user-speech in the ear canal with an in-ear microphone. This property allows it to work efficiently in high-noise environments, where traditional speech systems, employing external microphones, fail. It has been integrated with an iRobot PackBot 510 with EOD kit. The integrated system allows the hand-controller to be supplemented with speech for concurrent control. At Ft. Benning, the integrated system was tested by soldiers from the Officer Candidate School. The Experiment had dual focus: 1) Quantitative measurement of the time taken to complete each station and the cognitive load on users; 2) Qualitative evaluation of ease-of-use and ergonomics through soldier-feedback. Also of significant benefit to Think-A-Move was soldier-feedback on the speech-command vocabulary employed: What spoken commands are intuitive, and how the commands should be executed, e.g., limited-motion vs. unlimited-motion commands. Overall results from the Experiment are reported in the paper.

  17. Supertransvectants, cohomology, and deformations

    NASA Astrophysics Data System (ADS)

    Ben Fraj, Nizar; Laraiedh, Ismail; Omri, Salem

    2013-02-01

    Over the (1, N)-dimensional real superspace, N = 2, 3, we classify {osp}(N|2)-invariant binary differential operators acting on the superspaces of weighted densities, where {osp}(N|2) is the orthosymplectic Lie superalgebra. This result allows us to compute the first differential {osp}(N|2)-relative cohomology of the Lie superalgebra K(N) of contact vector fields with coefficients in the superspace of linear differential operators acting on the superspaces of weighted densities. We classify generic formal {osp}(3|2)-trivial deformations of the K(3)-module structure on the superspaces of symbols of differential operators. We prove that any generic formal {osp}(3|2)-trivial deformation of this K(3)-module is equivalent to its infinitesimal part. This work is the simplest generalization of a result by the first author et al. [Basdouri, I., Ben Ammar, M., Ben Fraj, N., Boujelbene, M., and Kammoun, K., "Cohomology of the Lie superalgebra of contact vector fields on {K}^{1|1} and deformations of the superspace of symbols," J. Nonlinear Math. Phys. 16, 373 (2009), 10.1142/S1402925109000431].

  18. Specific conductance and water temperature data for San Francisco Bay, California, for Water Year 2003

    USGS Publications Warehouse

    Buchanan, P.A.

    2004-01-01

    This article presents time-series graphs of specific-conductance and water-temperature data collected in San Francisco Bay during water year 2003 (October 1, 2002, through September 30, 2003). Specific-conductance and water-temperature data were recorded at 15-minute intervals at the following US Geological Survey (USGS) locations (Figure 1): • Suisun Bay at Benicia Bridge, near Benicia, CA. (BEN) (site # 11455780) • Carquinez Strait at Carquinez Bridge, near Crockett, CA. (CARQ) (site # 11455820) • Napa River at Mare Island Causeway, near Vallejo, CA. (NAP) (site # 11458370) • San Pablo Strait at Point San Pablo, CA. (PSP) (site # 11181360) • San Pablo Bay at Petaluma River Channel Marker 9, CA. (SPB) (site # 380519122262901) • San Francisco Bay at Presidio Military Reservation, CA. (PRES) (site # 11162690) • San Francisco Bay at San Mateo Bridge, near Foster City, CA. (SMB) (site # 11162765) Suspended-sediment-concentration data also were collected at most of these sites during water year 2003. Specific-conductance and water-temperature data from PSP, PRES, and SMB were recorded by the CA Department of Water Resources (DWR) before 1988, by the USGS National Research Program from 1988 to 1989, and by the USGS-DWR cooperative program since 1990. BEN, CARQ, NAP, and SPB were established in 1998 by USGS. The monitoring station at PRES was discontinued on November 12, 2002, due to shoaling at the site.

  19. Specific-conductance, water-temperature, and water-level data, San Francisco Bay, California, for water years 2001-2002

    USGS Publications Warehouse

    Buchanan, P.A.

    2003-01-01

    This article presents time-series plots of specific-conductance, water-temperature, and water-level data collected in San Francisco Bay during water years 2001 and 2002 (October 1, 2000, through September 30, 2002). Specific-conductance and water-temperature data were recorded at 15-minute intervals at the following US Geological Survey (USGS) locations (Figure 1): • Suisun Bay at Benicia Bridge, near Benicia, California (BEN) (site # 11455780) • Carquinez Strait at Carquinez Bridge, near Crockett, California (CARQ) (site # 11455820) • Napa River at Mare Island Causeway, near Vallejo, California (NAP) (site # 11458370) • San Pablo Strait at Point San Pablo, California (PSP) (site # 11181360) • San Pablo Bay at Petaluma River Channel Marker 9, California (SPB) (site # 380519122262901) • San Francisco Bay at Presidio Military Reservation, California (PRES) (site # 11162690) • San Francisco Bay at Pier 24, at San Francisco, California (P24) (site # 11162700) • San Francisco Bay at San Mateo Bridge, near Foster City, California (SMB) (site # 11162765). Water-level data were recorded only at PSP through January 1, 2001. Suspended-sediment concentration data also were collected at most of these sites and were published by Buchanan and Ganju (2003). The data from PSP, PRES, P24, and SMB were recorded by the California Department of Water Resources (DWR) before 1988, by the USGS National Research Program from 1988 to 1989, and by the USGSDWR cooperative program since 1990. BEN, CARQ, NAP, and SPB were established in 1998 by the USGS.

  20. Quantitation of Aristolochic Acids in Corn, Wheat Grain, and Soil Samples Collected in Serbia: Identifying a Novel Exposure Pathway in the Etiology of Balkan Endemic Nephropathy.

    PubMed

    Chan, Wan; Pavlović, Nikola M; Li, Weiwei; Chan, Chi-Kong; Liu, Jingjing; Deng, Kailin; Wang, Yinan; Milosavljević, Biljana; Kostić, Emina N

    2016-07-27

    While to date investigations provided convincing evidence on the role of aristolochic acids (AAs) in the etiology of Balkan endemic nephropathy (BEN) and upper urothelial cancer (UUC), the exposure pathways by which AAs enter human bodies to cause BEN and UUC remain obscure. The goal of this study is to test the hypothesis that environmental pollution by AAs and root uptake of AAs in the polluted soil may be one of the pathways by which AAs enter the human food chain. The hypothesis driving this study was that the decay of Aristolochia clematitis L., a AA-containing herbaceous plant that is found growing widespread in the endemic regions, could release free AAs to the soil, which could be taken up by food crops growing nearby, thereby transferring this potent human nephrotoxin and carcinogen into their edible parts. Using the highly sensitive and selective high-performance liquid chromatography coupled with fluorescence detection method, we identified and quantitated in this study for the first time AAs in corn, wheat grain, and soil samples collected from the endemic village Kutles in Serbia. Our results provide the first direct evidence that food crops and soil in the Balkans are contaminated with AAs. It is possible that the presence of AAs in edible parts of crops originating from the AA-contaminated soil could be one of the major pathways by which humans become exposed to AAs. PMID:27362729

  1. The geochemistry of oils and gases from the Cumberland overthrust sheet in Virginia and Tennessee: Chapter G.12 in Coal and petroleum resources in the Appalachian basin: distribution, geologic framework, and geochemical character

    USGS Publications Warehouse

    Dennen, Kristen O.; Deering, Mark; Burruss, Robert A.

    2014-01-01

    This study presents high-resolution gas chromatograms of oils and molecular and isotopic analyses of oil-associated gases from 17 wells producing in the Upper Cambrian to Lower Ordovician Knox Group, the Middle and Upper Ordovician Stones River Group, and the Upper Ordovician Trenton Limestone in the Cumberland overthrust sheet. The wells are located in the Ben Hur and Rose Hill fields in Lee County, Va., and in the Swan Creek field in Hancock and Claiborne Counties, Tenn. They produce oils typical of those from source rocks that are rich in Gloeocapsomorpha prisca (G. prisca) (Assemblage A-type kerogen). The Rose Hill oils appear to come from a source that contains a higher proportion of Assemblage A-type kerogen than the Ben Hur and Swan Creek oils. Extrapolation of the δ13C compositions of oil-associated gases to possible kerogen compositions gives estimates of -23 to -24 per mil within the range of isotopic compositions of known G. prisca source material. Gases produced from the Knox Group wells in the Swan Creek field are different from those in the Middle and Upper Ordovician reservoirs and come from a source with a broader range of isotopic values. Trends in isotopic and gasoline-range compositional parameters of the oils and associated gas isotopic and molecular compositions are most likely influenced by changes in local source depositional facies.

  2. New sections in Penicillium containing novel species producing patulin, pyripyropens or other bioactive compounds.

    PubMed

    Houbraken, J; Wang, L; Lee, H B; Frisvad, J C

    2016-06-01

    Subgenera and sections have traditionally been used in Penicillium classifications. In the past, this sectional classification was based on macro- and microscopic characters, and occasionally supplemented with physiological and/or extrolite data. Currently, 25 sections are accepted, largely based on phylogenetic data. Certain sections of subgenus Penicillium were never studied in detail using a multigene sequence approach combined with phenotypic, ecological and extrolite data. Based on a combined partial β-tubulin (BenA), calmodulin (CaM) and RNA polymerase II second largest subunit (RPB2) multigene sequence dataset, we introduce two new sections (Osmophila and Robsamsonia) in subgenus Penicillium and synonymize section Digitata with section Penicillium. The phylogeny correlates well with phenotypic, physiological and ecological data, and some extrolites were diagnostic for certain Penicillium sections. Furthermore, four new species belonging to the newly introduced sections are described using a polyphasic approach, including BenA, CaM and RPB2 sequences, macro- and micromorphological data and extrolite profiles. The new section Robsamsonia and the new species Penicillium robsamsonii and Penicillium samsonianum were introduced to celebrate Dr. Robert A. Samson's 70th birthday. PMID:27616794

  3. A Phylogenetic Analysis of Greek Isolates of Aspergillus Species Based on Morphology and Nuclear and Mitochondrial Gene Sequences

    PubMed Central

    Krimitzas, Antonios; Kouvelis, Vassili N.; Kapsanaki-Gotsi, Evangelia; Typas, Milton A.

    2013-01-01

    Aspergillus species originating from Greece were examined by morphological and molecular criteria to explore the diversity of this genus. The phylogenetic relationships of these species were determined using sequences from the ITS and IGS region of the nuclear rRNA gene complex, two nuclear genes (β-tubulin (benA) and RNA polymerase II second largest subunit (rpb2)) and two mitochondrial genes (small rRNA subunit (rns) and cytochrome oxidase subunit I (cox1)) and, where available, related sequences from databases. The morphological characters of the anamorphs and teleomorphs, and the single gene phylogenetic trees, differentiated and placed the species examined in the well-supported sections of Aenei, Aspergillus, Bispori, Candidi, Circumdati, Clavati, Cremei, Flavi, Flavipedes, Fumigati, Nidulantes, Nigri, Restricti, Terrei, Usti, and Zonati, with few uncertainties. The combined use of the three commonly employed nuclear genes (benA, rpb2, and ITS), the IGS region, and two less often used mitochondrial gene sequences (rns and cox1) as a single unit resolved several taxonomic ambiguities. A phylogenetic tree was inferred using Neighbour-Joining, Maximum Parsimony, and Bayesian methods. The strains examined formed seven well-supported clades within the genus Aspergillus. Altogether, the concatenated nuclear and mitochondrial sequences offer additional tools for an improved understanding of phylogenetic relationships within this genus. PMID:23762830

  4. Development, optimization and validation of a highly sensitive UPLC-ESI-MS/MS method for simultaneous quantification of amlodipine, benazeprile and benazeprilat in human plasma: application to a bioequivalence study.

    PubMed

    Rezk, Mamdouh R; Badr, Kamal A

    2014-09-01

    A rapid, simple, sensitive and specific LC-MS/MS method has been developed and validated for the simultaneous estimation of amlodipine (AML), benazepril (BEN) and benazeprilat (BNT) using eplerenone and torsemide as internal standards (IS). The Xevo TQD LC-MS/MS was operated under the multiple-reaction monitoring mode using electrospray ionization. Sample preparation involves both extraction and precipitation techniques. The reconstituted samples were chromatographed on Acquity UPLC BEH C18 (50mm×2.1mm, 1.7μm) column by pumping 0.1% formic acid and acetonitrile in a gradient mode at a flow rate of 0.45ml/min. A detailed validation of the method was performed as per the FDA guidelines and the standard curves were found to be linear in the range of 0.1-5ng/ml for AML; 5-1200ng/ml for both BEN and BNT. The intra-day and inter-day precision and accuracy results were within the acceptable limits. A run time of 2.5min for each sample made it possible to analyze more than 300 human plasma samples per day. The developed assay method was successfully applied to a bioequivalence study in human volunteers. PMID:24863555

  5. Effects of acidic precipitation on the water quality of streams in the Laurel Hill area, Somerset County, Pennsylvania, 1983-86

    USGS Publications Warehouse

    Barker, J.L.; Witt, E. C., III

    1990-01-01

    Five headwater streams in the Laurel Hill area in southwestern Pennsylvania were investigated from September 1983 through February 1986 to determine possible effects of acidic precipitation on water quality. Precipitation in the Laurel Hill area is among the most acidic in the Nation, with a mean volume-weighted pH of 4.06. Sulfate is the dominant acid-forming anion, averaging 3.6 milligrams per liter or about 50 kilograms per hectare in wet deposition alone. Nitrate averages about 2 milligrams per liter or 7 kilograms per hectare in the study area. Stream chemistry in the five streams is quite variable and apparently is influenced to a large degree by the bedrock geology and by small amounts of alkaline material in watershed soils. Three of the five streams with no or little acid-neutralizing capacity presently are devoid of fish because of low pH and elevated aluminum concentrations. Aluminum concentrations increase in the other two streams during rainfall and snowmelt despite comparatively higher base flow and acid-neutralizing capacities. Comparison of the chemistry of streamflow during 14 storm events at South Fork Bens Creek and North Fork Bens Creek reveals similar chemical responses when discharge suddenly increases. Concentrations of dissolved metals and sulfate increased during stormflow and snowmelt runoff, whereas concentrations of base cations, silica, and chloride decreased. Nitrate concentrations were not affected by rainfall runoff by tended to increase with snowmelt runoff.

  6. Virtual-state character of the 9Be1 /2+ state in the 9Be(γ ,n )8Be reaction

    NASA Astrophysics Data System (ADS)

    Odsuren, Myagmarjav; Kikuchi, Yuma; Myo, Takayuki; Aikawa, Masayuki; Katō, Kiyoshi

    2015-07-01

    We study the character of the first excited 1 /2+ state of 9Be, which is observed as a low-lying sharp peak in the cross section of 9Be(γ ,n ) 2 4He just above the 8Be+n threshold. Using the α +α +n three-body model, we describe the ground and excited unbound states of 9Be above the α +α +n threshold. Applying the complex scaling method to the three-body model, we find no 1 /2+ resonant solutions with the scaling angle of θ ≤15∘ , while the low-lying peak in the photodisintegration cross section is reproduced in the present calculation. It is found that the 8Be+n continuum states dominate the low-lying peak in the cross section. Furthermore, using the analytical continuation of the coupling constant of the three-body interaction for the α +α +n system, we discuss the virtual-state character of the 1 /2+ state.

  7. Polyphasic taxonomy of the genus Talaromyces

    PubMed Central

    Yilmaz, N.; Visagie, C.M.; Houbraken, J.; Frisvad, J.C.; Samson, R.A.

    2014-01-01

    The genus Talaromyces was described by Benjamin in 1955 as a sexual state of Penicillium that produces soft walled ascomata covered with interwoven hyphae. Phylogenetic information revealed that Penicillium subgenus Biverticillium and Talaromyces form a monophyletic clade distinct from the other Penicillium subgenera. Subsequently, in combination with the recent adoption of the one fungus one name concept, Penicillium subgenus Biverticillium was transferred to Talaromyces. At the time, the new combinations were made based only on phylogenetic information. As such, the aim of this study was to provide a monograph on Talaromyces applying a polyphasic species concept, including morphological, molecular and physiological characters. Based on an ITS, BenA and RPB2 multigene phylogeny, we propose a new sectional classification for the genus, placing the 88 accepted species into seven sections, named sections Bacillispori, Helici, Islandici, Purpurei, Subinflati, Talaromyces and Trachyspermi. We provide morphological descriptions for each of these species, as well as notes on their identification using morphology and DNA sequences. For molecular identification, BenA is proposed as a secondary molecular marker to the accepted ITS barcode for fungi. PMID:25492983

  8. Quantitative analysis of seismic trapped waves in the rupture zone of the Landers, 1992, California earthquake: Evidence for a shallow trapping structure

    NASA Astrophysics Data System (ADS)

    Peng, Z.; Ben-Zion, Y.; Michael, A. J.; Zhu, L.

    2002-12-01

    velocity FZ material. To put additional constraints on properties of the shallow trapping structure at Landers, we modeled FZ trapped waves with a genetic inversion algorithm (Michael and Ben-Zion, 2002) using the 2D analytical solution of Ben-Zion and Aki (1990) and Ben-Zion (1998) for a uniform FZ structure. The synthetic waveform modeling indicates an effective FZ waveguide with depth of about 3-5 km, width on the order of 200 m, shear velocity reduction relative to the host rock of about 40-50%, and S wave quality factor of about 30. The modeling also shows that the waveguide is not centered at the exposed fault trace (station C00), but at a distance of about 100 m east of C00. Shallow trapping structures with similar properties appear to characterize also the Karadere-Duzce branch of the north Anatolian fault (Ben-Zion et al., 2002) and the Parkfield segment of the San Andreas fault (Michael and Ben-Zion, 2002; Korneev et al., 2002).

  9. Obituary: Benjamin Franklin Peery Jr. (1922-2010)

    NASA Astrophysics Data System (ADS)

    Cowley, Charles

    2011-12-01

    Professor Benjamin F. Peery, Jr. died at his home in Silver Spring, MD of natural causes on 30 November 2010. His full life began in St. Joseph, MO (home of the Pony Express) on 4 March 1922. His father was a railway mail clerk, so his family moved frequently. Most of his childhood was spent in southeastern Minnesota. He enlisted in the army in 1942, and served in campaigns in North Africa and Italy. After his discharge in 1945, he enrolled in the University of Minnesota, earning a BS in Physics in 1949. One of his early hobbies was to build and fly model airplanes. His intention to pursue aeronautical engineering changed to physics, but after receiving a MS in physics from Fisk University in 1955, he decided on a career in astronomy. He told the editors of the PBS series The Astronomers (1991, in which his career is highlighted) he thought it was shamefully absurd not to know what made the stars shine. So he began PhD studies in astronomy at the University of Michigan (Ann Arbor). His dissertation was on the complex eclipsing binary VV Cephei, where a compact hot star passes behind a cool giant star, revealing the structure of that giant's atmosphere. This task was especially demanding because of the complexity of the system's spectrum and the formidable array of observations assembled by Ben's advisor, Dean McLaughlin. Fortunately, Ben's strong physics background enabled him to design and construct one of the first oscilloscope measuring engines, which his fellow students called the PeeryScope. The final (1961) dissertation is an impressive combination of observational and astrophysical analysis. His degree was obtained in 1962; he had already begun a career at the University of Indiana, where he taught and did research (1959--1976). The Indiana years were highly productive. In addition to his own research, he was advisor on six PhD dissertations, and a master's thesis. Several of his students have also had productive careers. An ADS search on his students' names

  10. Archaeological Geophysics in Israel: Past, Present and Future

    NASA Astrophysics Data System (ADS)

    Eppelbaum, L. V.

    2009-04-01

    Israel is a country with diverse and rapidly changeable environments where is localized a giant number of archaeological objects of various age, origin and size. The archaeological remains occur in a complex (multi-layered and variable) geological-archaeological media. It is obvious that direct archaeological excavations cannot be employed at all localized and supposed sites taking into account the financial, organizational, ecological and other reasons. Therefore, for delineation of buried archaeological objects, determination their physical-geometrical characteristics and classification, different geophysical methods are widely applied. The number of employed geophysical methodologies is constantly increasing and now Israeli territory may be considered as a peculiar polygon for various geophysical methods testing. The geophysical investigations at archaeological sites in Israel could be tentatively divided on three stages: (1) past [- 1990] (e.g., Batey, 1987; Ben-Menahem, 1979; Dolphin, 1981; Ginzburg and Levanon, 1977; Karcz et al., 1977; Karcz and Kafri, 1978; Tanzi et al., 1983; Shalem, 1949; Willis, 1928), (2) present [1991 - 2008] (e.g., Bauman et al., 2005; Ben-Dor et al., 1999; Ben-Yosef et al., 2008; Berkovitch et al., 2000; Borradaile, 2003; Boyce et al., 2004; Bruins et al., 2003; Daniels et al., 2003; Ellenblum et al., 1998; Eppelbaum, 1999, 2000a, 2000b, 2005, 2007a, 2007b, 2008b; Eppelbaum and Ben-Avraham, 2002; Eppelbaum and Itkis, 2000, 2001; 2003, 2009; Eppelbaum et al., 2000a, 2000b, 2001a, 2001b, 2003a, 2003b, 2004a, 2004b; 2005, 2006a, 2006b, 2006c, 2006d, 2007, 2009a, 2009b; Ezersky et al., 2000; Frumkin et al., 2003; Itkis and Eppelbaum, 1998; Itkis, 2003; Itkis et al., 2002, 2003, 2008; Jol et al., 2003, 2008; Kamai and Hatzor, 2007; Khesin et al., 1996; Korjenkov and Mazor, 1999; Laukin et al., 2001; McDermott et al., 1993; Marco, 2008; Marco et al., 2003; Nahas et al., 2006; Neishtadt et al., 2006; Nur and Ron, 1997; Paparo, 1991; Porat

  11. Socio-economic development with regard to the availability of resources in Benin, West Africa

    NASA Astrophysics Data System (ADS)

    Mbarek, R.; Behle, C.; Doevenspeck, M.; Mulindabigwi, V.; Schopp, M.; Singer, U.; Henrichsmeyer, W.; Janssens, M.; Schug, W.

    2003-04-01

    The socio-economic part within the IMPETUS-Project analyses interdependencies between resource availability and socio-economic development in Benin. The results of various research activities of natural and social sciences are integrated in a modelling system, in order to calculate development scenarios of resource utilisation and food security in Benin for the next two decades. Missing data concerning water usage and economic parameters are collected in field surveys, in co-operation with other disciplines and stakeholders on site, investigating the upper Ouémé-catchment in particular. The demand of water is analysed by water frequency observation, household analysis and interviews with experts and shows the effects of changing socio-economic parameters on demand growth. The analysis of water availability investigates the question, how the gap between water demand and water availability, due to demographic, social and natural conditions, may be closed by improved management systems and improved technical equipment. A further field of interest is to measure the influence of land use systems and rain variability on carbon balance and food security. Rain variability associated with inadequate land use systems has become the most important factor for determining food insecurity and emission of (global )greenhouse gases in Benin. Therefore, farmers in Benin need efficient water management systems, otherwise they are obliged to extend their agricultural areas or to migrate towards less occupied regions. The results of the above mentioned research activities are introduced in the modelling system BenIMPACT (Benin Integrated Modelling System for Policy Analysis, Climate and Technology Change). It consists of an agricultural sector model (spatial, synthetic, non-linear), a tool to calculate water balances and a basic data system, which provides data and results in a mapping tool (BenMap). Establishing BenIMPACT as a decision support system in corresponding institutions

  12. Disaggregation of Rainy Hours: Compared Performance of Various Models.

    NASA Astrophysics Data System (ADS)

    Ben Haha, M.; Hingray, B.; Musy, A.

    In the urban environment, the response times of catchments are usually short. To de- sign or to diagnose waterworks in that context, it is necessary to describe rainfall events with a good time resolution: a 10mn time step is often necessary. Such in- formation is not always available. Rainfall disaggregation models have thus to be applied to produce from rough rainfall data that short time resolution information. The communication will present the performance obtained with several rainfall dis- aggregation models that allow for the disaggregation of rainy hours into six 10mn rainfall amounts. The ability of the models to reproduce some statistical character- istics of rainfall (mean, variance, overall distribution of 10mn-rainfall amounts; ex- treme values of maximal rainfall amounts over different durations) is evaluated thanks to different graphical and numerical criteria. The performance of simple models pre- sented in some scientific papers or developed in the Hydram laboratory as well as the performance of more sophisticated ones is compared with the performance of the basic constant disaggregation model. The compared models are either deterministic or stochastic; for some of them the disaggregation is based on scaling properties of rainfall. The compared models are in increasing complexity order: constant model, linear model (Ben Haha, 2001), Ormsbee Deterministic model (Ormsbee, 1989), Ar- tificial Neuronal Network based model (Burian et al. 2000), Hydram Stochastic 1 and Hydram Stochastic 2 (Ben Haha, 2001), Multiplicative Cascade based model (Olsson and Berndtsson, 1998), Ormsbee Stochastic model (Ormsbee, 1989). The 625 rainy hours used for that evaluation (with a hourly rainfall amount greater than 5mm) were extracted from the 21 years chronological rainfall series (10mn time step) observed at the Pully meteorological station, Switzerland. The models were also evaluated when applied to different rainfall classes depending on the season first and on the

  13. The HD 209458 system: a re-assessment

    NASA Astrophysics Data System (ADS)

    Ballester, G. E.

    2014-03-01

    The hot-Jupiter HD 209458b was the first exoplanet on which an extended upper atmosphere was discovered in H I reaching out to Roche-lobe distances (Vidal-Madjar et al. 2003; Ben-Jaffel 2008). Subsequently the heavier and abundant species of O I and C II were also observed, presumably dragged along in a strong hydrodynamic outflow of the lighter bulk hydrogen gas (Vidal-Madjar et al. 2004; Ben-Jaffel & Hosseini 2010). Recently, an extended nebula of Si III ions was reported from COS observations in contradiction with STIS observations that show no detection (Linsky et al. 2010; Vidal-Madjar et al. 2004). There is also a very recent detection of extended Mg I ions on this planet but not of Mg II as would be expected (Vidal-Madjar et al. 2013). Here we present new results from a study where we have re-analyzed all available HST FUV data on Si III for this system, showing that 7 out of 8 transit observations with STIS do not show any transit signature in Si III, and also showing the reported COS detection to be invalid because the observations used to represent the off-transit stellar flux showed a similar ~9% variability than the reported ~8% transit signature (Ballester and Ben- Jaffel 2014). The Mg I detection reveals that magnesium is not effectively removed by silicate condensation in the lower atmosphere of this planet, and consequently, that silicon should also be present in some form, most likely in the lower ionization state of Si II. The detection of Mg I and future potential detection of some form of silicon open a new avenue to study both upper and lower regions of the same atmosphere. On the top region, species are controlled principally by the huge stellar input. Here, we also present new results from a study of the star HD 290458, where we find evidence for low activity on a long-term basis (Ballester et al. 2014). This implies a significantly lower EUV flux to the planet than assumed in previous hydrodynamic and upper-atmospheric modeling of the hot

  14. Preliminary Results on Seismicity and Fault Zone Structure Along the 1944 Rupture of the North Anatolian Fault East of Ismetpasa

    NASA Astrophysics Data System (ADS)

    Ozakin, Y.; Ben-Zion, Y.; Aktar, M.; Karabulut, H.; Peng, Z.

    2010-12-01

    The North Anatolian Fault (NAF), a continental plate boundary similar in some respects to the San Andreas Fault (SAF), is of great importance to Turkey in terms of seismic hazard. The geological history, lithology & topography suggest that the NAF is generally a bimaterial interface separating different rock bodies. Theoretical and observational studies suggest that there may be fundamental differences between properties of earthquakes and seismic radiation generated by ruptures along interfaces that separate similar and dissimilar solids (e.g., Weertman 1980; Ben-Zion 2001; Dor et al. 2008; Ampuero & Ben-Zion 2008; Zaliapin & Ben-Zion 2010). High-resolution imaging of the internal fault structure in various locations can be used to test hypotheses associated with bimaterial ruptures, and estimate expected shaking hazard based on the results. It is also important to clarify the geometry and seismic potential of various sections through high-resolution studies of seismicity. To begin such studies, we conducted a pilot seismic experiment east of Ismetpasa on the 1944 rupture of the NAF with a line of 6-11 seismometers that cross the fault. The location was chosen because it is within the area where Dor et al. (2008) found strong asymmetry of rock damage that may reflect repeating ruptures on a bimaterial fault interface. The location also coincides with a section of the NAF that is partially creeping at least at shallow depth. The creep rate decayed from a maximum of 4-5 cm/yr following the 1994 earthquake to a present value of to 0.7 cm/yr (Cakir et al. 2005). The small local network has been operating for ~2.5 yr. Earthquake detection was done by a manual inspection of automatic identification of candidate events. To date we were able to detect only ~235 events in the magnitude range -1 to 2.5 within a radius of 45 km from the center of the network. Using template earthquakes for detecting more events was not successful so far, as the signals produced by the

  15. [Determination of Gasoline Composition Based on Raman Spectroscopy].

    PubMed

    Zhang, Bing; Deng, Zhi-yin; Zheng, Jing-kui; Wang, Xiao-ping

    2015-06-01

    For the purpose of the rapid prediction of every composition in gasoline, the Raman spectra of the gasoline brand 93 and 97, a batch of one-one mixtures with aromatic, olefin, ben, methanol and ethanol with different ratios are measured, 410 mixture samples were measured totally in this research. The obtained Raman spectra were preprocessed by a series of processing, they were data smoothing, baseline deduction and spectral normalized, etc. After that 33 characteristic peaks were extracted to be the eigenvalues for the whole Raman spectra. According to the current national standard test method, the values of every composition were measured by the gas chromatography. By using the eigenvalues as inputs, and actual contents of aromatic, olefin, ben, methanol and ethanol got from gas chromatography as outputs, two mathematical models of multi-output least squares support vector regression and partial least squares combination with multiple regression analysis were established to predict the values of the above compositions of a sample, respectively. The predicting results were compared with the values calculated from the gas chromatography measurement results and the mixture proportions, the multi-output least squares support vector regression has a better effects, and the obtained root mean square error of prediction for aromatic, olefin, ben, methanol and ethanol are 0.27%, 0.27%, 0.22%, 0.17%, 0.14%; the correlation coefficients are 0.999 3, 0.998 5, 0.998 6, 0.992 3, 0.993 5, respectively. This model is also applied to the detection of the unknown sample, the root mean square error of the prediction for the results does not exceed 0.5%, which can achieve the measurement requirements in the industry. Results show that the Raman spectra analysis technology based on multi-output least squares support vector regression can be a precise, fast and convenient new method for gasoline composition detection, and can be applied to the quality control of the gasoline

  16. Reliability and validity of the Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF) in evaluations of chronic low back pain patients.

    PubMed

    Tarescavage, Anthony M; Scheman, Judith; Ben-Porath, Yossef S

    2015-06-01

    The purpose of the current study was to investigate the reliability and concurrent validity of Minnesota Multiphasic Personality Inventory (MMPI)-2-Restructured Form (2-RF) (Ben-Porath & Tellegen, 2008/2011) scores in a sample of 811 chronic low back pain patients (346 males, 529 females) beginning treatment in a short-term interdisciplinary pain rehabilitation program. We calculated internal consistency coefficients, mean-item correlations, and SEM for all substantive scales, as well as zero-order correlations with collateral medical record information and self-report testing. Results indicated reliability and validity for most of the MMPI-2-RF substantive scales. Implications of these findings and limitations of this study are discussed. PMID:25436662

  17. Big Bang Day : The Great Big Particle Adventure - 3. Origins

    SciTech Connect

    2009-10-13

    In this series, comedian and physicist Ben Miller asks the CERN scientists what they hope to find. If the LHC is successful, it will explain the nature of the Universe around us in terms of a few simple ingredients and a few simple rules. But the Universe now was forged in a Big Bang where conditions were very different, and the rules were very different, and those early moments were crucial to determining how things turned out later. At the LHC they can recreate conditions as they were billionths of a second after the Big Bang, before atoms and nuclei existed. They can find out why matter and antimatter didn't mutually annihilate each other to leave behind a Universe of pure, brilliant light. And they can look into the very structure of space and time - the fabric of the Universe

  18. Tectonique quaternaire et plis de rampe dans le golfe d'Hammamet ( offshore tunisien)

    NASA Astrophysics Data System (ADS)

    Ben Romdhane, Malika; Brahim, Noureddine; Ouali, Jamel; Mercier, Éric

    2006-05-01

    The Jriba trough is an Upper Miocene graben located within the Tunisian offshore Gulf of Hammamet area, east of the Atlas front. This distensive structure suffered a compressive event during the Early Quaternary (Villafranchian). The Jriba structure was previously interpreted as 'flower structure', which possibly complicated by halokinetics movements. A new analysis of a set of seismic lines crossing the Jriba trough allows us to propose a new tectonic model where the Villafranchian deformation is characterized by (1) occurrence of a decollement level cutting Messinian to Pliocene layers; and (2) the growth of fault-related folds (fault-propagation fold). The NE-SW Miocene, inherited normal faults, locate the position of the ramps and folds whereas the NW-SE inherited normal faults are reactivated as tear faults. These NW-SE tear faults define various domains of different shortening values (one kilometre at maximum). To cite this article: M. Ben Romdhane et al., C. R. Geoscience 338 (2006).

  19. Does it Make Sense to Speak of Self-Locating Uncertainty in the Universal Wave Function? Remarks on Sebens and Carroll

    NASA Astrophysics Data System (ADS)

    Kent, Adrian

    2015-02-01

    Following a proposal of Vaidman (Int Stud Philos Sci 12:245-261, 1998) (in: Zalta EN (ed) The Stanford encyclopaedia of philosophy, 2014) (in: Ben-Menahem Y, Hemmo M (ed) The probable and the improbable: understanding probability in physics, essays in memory of Itamar Pitowsky, 2011), Sebens and Carroll (Quantum theory: a two-time success story 2014), (arXiv preprint arXiv:1405.7577 2014) have argued that in Everettian (i.e. purely unitary) quantum theory, observers are uncertain, before they complete their observation, about which Everettian branch they are on. They argue further that this solves the problem of making sense of probabilities within Everettian quantum theory, even though the theory itself is deterministic. We note some problems with these arguments.

  20. NE Ohio Urban Growth Monitoring and Modeling Prototype. Revised

    NASA Technical Reports Server (NTRS)

    Siebert, Loren; Klosterman, Richard E.

    2001-01-01

    At the University of Akron, Dr. Loren Siebert, Dr. Richard Klosterman, and their graduate research assistants (Jung-Wook Kim, Mohammed Hoque, Aziza Parveen, and Ben Stabler) worked on the integration of remote sensing and GIs-based planning support systems. The primary goal of the project was to develop methods that use remote sensing land cover mapping and GIs-based modeling to monitor and project urban growth and farmland loss in northeast Ohio. Another research goal has been to use only GIS data that are accessible via the World Wide Web, to determine whether Ohio's small counties and townships that do not currently have parcel-level GIS systems can apply these techniques. The project was jointly funded by NASA and USGS OhioView grants during the 2000-2001 academic year; the work is now being continued under a USGS grant.

  1. Validity of the Externalizing Spectrum Inventory in a Criminal Offender Sample: Relations with Disinhibitory Psychopathology, Personality, and Psychopathic Features

    PubMed Central

    Venables, Noah C.; Patrick, Christopher J.

    2013-01-01

    The Externalizing Spectrum Inventory (ESI; Krueger, Markon, Patrick, Benning, & Kramer, 2007) provides a self-report based method for indexing a range of correlated problem behaviors and traits in the domain of deficient impulse control. The ESI organizes lower-order behaviors and traits of this kind around higher-order factors encompassing general disinhibitory proneness, callous-aggression, and substance abuse. The current study used data from a male prisoner sample (N = 235) to evaluate the validity of ESI total and factor scores in relation to external criterion measures consisting of externalizing disorder symptoms (including child and adult antisocial deviance and substance-related problems) assessed via diagnostic interview, personality traits assessed by self-report, and psychopathic features as assessed by both interview and self-report. Results provide evidence for the validity of the ESI measurement model and point to its potential utility as a referent for research on the neurobiological correlates and etiological bases of externalizing proneness. PMID:21787091

  2. Role of acid diffusion in matrix acidizing of carbonates

    SciTech Connect

    Hoefner, M.L.; Fogler, H.S.; Stenius, P.; Sjoblom, J.

    1987-02-01

    To increase the efficiency of matrix treatments in carbonates, a new type of retarded acid-in-oil microemulsion system has ben developed. The microemulsion is of low viscosity but can exhibit acid diffusion rates two orders of magnitude lower than aqueous HCl. Decreased acid diffusion delays spending and allows live acid to penetrate the rock matrix more uniformly and to greater distances. Coreflood results show that the microemulsion can stimulate cores in fewer PV's and under conditions of low injection rates where aqueous HCl fails completely. The microemulsion could also conceivably increase acid penetration along any natural fractures and fissures that may be present, thus increasing acidizing efficiency in this type of treatment. The relationship between the acid diffusion rate and the ability of the fluid to matrix-stimulate limestone is investigated.

  3. ThrowBot: design considerations for a man-portable throwable robot

    NASA Astrophysics Data System (ADS)

    Barnes, Mitchell; Everett, H. R.; Rudakevych, Pavlo

    2005-05-01

    The pocket-sized ThrowBot is a sub-kilogram-class robot that provides short-range remote eyes and ears for urban combat. This paper provides an overview of lessons learned from experience, testing, and evaluation of the iRobot ThrowBot developed under the Defense Advanced Research Projects Agency (DARPA) Tactical Mobile Robots (TMR) program. Emphasis has been placed on investigating requirements for the next generation of ThrowBots to be developed by iRobot Corporation and SPAWAR Systems Center, San Diego (SSC San Diego) Unmanned Systems Branch. Details on recent evaluation activities performed at the Military Operations in Urban Terrain (MOUT) test site at Fort Benning, GA, are included, along with insights obtained throughout the development of the ThrowBot since its inception in 1999 as part of the TMR program.

  4. The ISOPHOT Mapping Simulation System

    NASA Astrophysics Data System (ADS)

    Gabriel, C.; Hur, M.

    2002-12-01

    From version 9.0 onwards, the ISOPHOT Interactive Anal- ysis (PIA) package offers its users an integrated mapping simu- lation system, capable of generating sky images including sev- eral point / extended sources on a flat / gradient background, simulating what ISOPHOT would have recorded under certain instrument and spacecraft raster configurations. While the ben- efits of performing simulations for accessing the efficiency, ac- curacy, confusion level, etc., on different mapping algorithms and deconvolution techniques in and outside PIA are mostly of interest to calibrators and instrument specialists, it is also very important for a general observer because this highly user friendly system provides the possibility of simulating his / her observation by matching the selected observing mode.

  5. Cytoskeletal Mechanics

    NASA Astrophysics Data System (ADS)

    Mofrad, Mohammad R. K.; Kamm, Roger D.

    2006-10-01

    1. Introduction and the biological basis for cell mechanics Mohammad R. K. Mofrad and Roger Kamm; 2. Experimental measurements of intracellular mechanics Paul Janmey and Christoph Schmidt; 3. The cytoskeleton as a soft glassy material Jeffrey Fredberg and Ben Fabry; 4. Continuum elastic or viscoelastic models for the cell Mohammad R. K. Mofrad, Helene Karcher and Roger Kamm; 5. Multiphasic models of cell mechanics Farshid Guuilak, Mansoor A. Haider, Lori A. Setton, Tod A. Laursen and Frank P. T. Baaijens; 6. Models of cytoskeletal mechanics based on tensegrity Dimitrije Stamenovic; 7. Cells, gels and mechanics Gerald H. Pollack; 8. Polymer-based models of cytoskeletal networks F. C. MacKintosh; 9. Cell dynamics and the actin cytoskeleton James L. McGrath and C. Forbes Dewey, Jr; 10. Active cellular motion: continuum theories and models Marc Herant and Micah Dembo; 11. Summary Mohammad R. K. Mofrad and Roger Kamm.

  6. Cytoskeletal Mechanics

    NASA Astrophysics Data System (ADS)

    Mofrad, Mohammad R. K.; Kamm, Roger D.

    2011-08-01

    1. Introduction and the biological basis for cell mechanics Mohammad R. K. Mofrad and Roger Kamm; 2. Experimental measurements of intracellular mechanics Paul Janmey and Christoph Schmidt; 3. The cytoskeleton as a soft glassy material Jeffrey Fredberg and Ben Fabry; 4. Continuum elastic or viscoelastic models for the cell Mohammad R. K. Mofrad, Helene Karcher and Roger Kamm; 5. Multiphasic models of cell mechanics Farshid Guuilak, Mansoor A. Haider, Lori A. Setton, Tod A. Laursen and Frank P. T. Baaijens; 6. Models of cytoskeletal mechanics based on tensegrity Dimitrije Stamenovic; 7. Cells, gels and mechanics Gerald H. Pollack; 8. Polymer-based models of cytoskeletal networks F. C. MacKintosh; 9. Cell dynamics and the actin cytoskeleton James L. McGrath and C. Forbes Dewey, Jr; 10. Active cellular motion: continuum theories and models Marc Herant and Micah Dembo; 11. Summary Mohammad R. K. Mofrad and Roger Kamm.

  7. Study of the {sup 10}B(p,alpha){sup 7}Be Reaction through the Indirect Trojan Horse Method

    SciTech Connect

    Puglia, S. M. R.; Romano, S.; Lamia, L.; Spitaleri, C.; Cherubini, S.; Gulino, M.; La Cognata, M.; Pizzone, R. G.; Rapisarda, G. G.; Sergi, M. L.; Tudisco, S.; Del Santo, M. G.; Carlin, N.; Souza, F.; Szanto de Toledo, A.; Kroha, V.; Kubono, S.; Wakabayashi, Y.; Yamaguchi, H.; Li, C.

    2010-03-01

    The {sup 10}B(p,alpha){sup 7}Be reaction is the main responsible for {sup 10}B destruction in stellar interior. In such environments the process takes places mainly through a resonant state of the compound {sup 11}C nucleus. The {sup 10}B(p,alpha){sup 7}Be reaction has been studied by means of the Trojan Horse Method using the {sup 2}H({sup 10}B,alpha{sup 7}Be)n three-body reaction. The experiment was performed at the Laboratori Nazionali del Sud in Catania. The {sup 10}B(p,alpha){sup 7}Be reaction cross section has been extracted at low neutron momentum.

  8. Optimal multiyear management of a water supply system under uncertainty: Robust counterpart approach

    NASA Astrophysics Data System (ADS)

    Housh, Mashor; Ostfeld, Avi; Shamir, Uri

    2011-10-01

    In this paper, the robust counterpart (RC) approach (Ben-Tal et al., 2009) is applied to optimize management of a water supply system (WSS) fed from aquifers and desalination plants. The water is conveyed through a network to meet desired consumptions, where the aquifers recharges are uncertain. The objective is to minimize the net present value cost of multiyear operation, satisfying operational and physical constraints. The RC is a min-max guided approach, which converts the original problem into a deterministic equivalent problem, requiring only that the uncertain parameters resides within a user-defined uncertainty set. The robust policy obtained by the RC approach is compared with polices obtained by other decision-making approaches including stochastic approaches.

  9. Congruent numbers with many prime factors

    PubMed Central

    Tian, Ye

    2012-01-01

    Mohammed Ben Alhocain, in an Arab manuscript of the 10th century, stated that the principal object of the theory of rational right triangles is to find a square that when increased or diminished by a certain number, m becomes a square [Dickson LE (1971) History of the Theory of Numbers (Chelsea, New York), Vol 2, Chap 16]. In modern language, this object is to find a rational point of infinite order on the elliptic curve . Heegner constructed such rational points in the case that m are primes congruent to 5,7 modulo 8 or twice primes congruent to 3 modulo 8 [Monsky P (1990) Math Z 204:45–68]. We extend Heegner's result to integers m with many prime divisors and give a sketch in this report. The full details of all the proofs will be given in ref. 1 [Tian Y (2012) Congruent Numbers and Heegner Points, arXiv:1210.8231]. PMID:23213259

  10. Electron microscope methods in the search for the earliest life forms on Earth (in 3.5-3.3 GA cherts from the Barberton Greenstone Belt, South Africa): applications for extraterrestrial life studies

    NASA Astrophysics Data System (ADS)

    Westall, Frances; Gerneke, Dane

    1998-07-01

    A suite of previously unknown microfossils and related biogenic structures has been revealed in some of the oldest sediments on Earth using scanning electron microscopy. High resolution scanning electron microscopy of HF-etched, biolaminated charts has brought to light a variety of small fossil coccoid and rod-shaped bacteria and associated fossil biofilms containing bedding planes. These microfossils have ben completely replaced by minerals. This vastly improved early Archaean microfossil database sheds new light on the diversity of life on Earth relatively soon after the cessation of heavy bolide bombardment at about 3.8 Ga. This is the critical period when life may have been able to develop on Mars and these early Archaean terrestrial microfossils will serve as valuable analogues for possible extraterrestrial life.

  11. Analysis of pharmaceutical materials through the use of FT-Raman microprobe imaging

    NASA Astrophysics Data System (ADS)

    Rodriguez, Christiane

    1999-04-01

    The characterization of pharmaceutical solids has always ben a concern for the pharmaceutical scientist, whether it be a formulator, analytical chemist or process chemist. Traditionally, characterization meant chemical purity, but today a more comprehensive characterization is crucial for a safe and consistent pharmaceutical product. Typically, FTIR and FT-Raman are the vibrational techniques used to physical characterize solids. Recent advances in imaging technology have made FT-Raman microscopy another powerful tool for obtaining information of pharmaceutical products. This advance has made it possible to not only obtain chemical information, but gives the ability to spatially resolve the obtained information. Descriptions of various experimental procedures for analyzing formulated tablets as well as other materials of pharmaceutical interest using imaging techniques will be given.

  12. Basic amino acid residues located in the N-terminal region of BEND3 are essential for its nuclear localization.

    PubMed

    Shiheido, Hirokazu; Shimizu, Jun

    2015-02-20

    BEN domain-containing protein 3 (BEND3) has recently been reported to function as a heterochromatin-associated protein in transcriptional repression in the nucleus. BEND3 should have nuclear localization signals (NLSs) to localize to the nucleus in light of its molecular weight, which is higher than that allowed to pass through nuclear pore complexes. We here analyzed the subcellular localization of deletion/site-directed mutants of human BEND3 by an immunofluorescence assay in an attempt to identify the amino acids essential for its nuclear localization. We found that three basic amino acid residues located in the N-terminal region of BEND3 (BEND356-58, KRK) are essential, suggesting that these residues play a role as a functional NLS. These results provide valuable information for progressing research on BEND3. PMID:25600804

  13. Nuclear Resonance Fluorescence for Materials Assay

    SciTech Connect

    Quiter, Brian J.; Ludewigt, Bernhard; Mozin, Vladimir; Prussin, Stanley

    2009-06-29

    This paper discusses the use of nuclear resonance fluorescence (NRF) techniques for the isotopic and quantitative assaying of radioactive material. Potential applications include age-dating of an unknown radioactive source, pre- and post-detonation nuclear forensics, and safeguards for nuclear fuel cycles Examples of age-dating a strong radioactive source and assaying a spent fuel pin are discussed. The modeling work has ben performed with the Monte Carlo radiation transport computer code MCNPX, and the capability to simulate NRF has bee added to the code. Discussed are the limitations in MCNPX?s photon transport physics for accurately describing photon scattering processes that are important contributions to the background and impact the applicability of the NRF assay technique.

  14. Nuclear Resonance Fluorescence for Materials Assay

    SciTech Connect

    Quiter, Brian; Ludewigt, Bernhard; Mozin, Vladimir; Prussin, Stanley

    2009-06-05

    This paper discusses the use of nuclear resonance fluorescence (NRF) techniques for the isotopic and quantitative assaying of radioactive material. Potential applications include age-dating of an unknown radioactive source, pre- and post-detonation nuclear forensics, and safeguards for nuclear fuel cycles Examples of age-dating a strong radioactive source and assaying a spent fuel pin are discussed. The modeling work has ben performed with the Monte Carlo radiation transport computer code MCNPX, and the capability to simulate NRF has bee added to the code. Discussed are the limitations in MCNPX's photon transport physics for accurately describing photon scattering processes that are important contributions to the background and impact the applicability of the NRF assay technique.

  15. Fifteen new species of Penicillium.

    PubMed

    Visagie, C M; Renaud, J B; Burgess, K M N; Malloch, D W; Clark, D; Ketch, L; Urb, M; Louis-Seize, G; Assabgui, R; Sumarah, M W; Seifert, K A

    2016-06-01

    We introduce 15 new species of Penicillium isolated from a diverse range of locations, including Canada, Costa Rica, Germany, Italy, New Zealand, Tanzania, USA and the Dry Valleys of Antarctica, from a variety of habitats, including leaf surfaces in tropical rain forests, soil eaten by chimpanzees, infrabuccal pockets of carpenter ants, intestinal contents of caterpillars and soil. The new species are classified in sections Aspergilloides (1), Canescentia (2), Charlesia (1), Exilicaulis (3), Lanata-Divaricata (7) and Stolkia (1). Each is characterised and described using classical morphology, LC-MS based extrolite analyses and multigene phylogenies based on ITS, BenA and CaM. Significant extrolites detected include andrastin, pulvilloric acid, penitrem A and citrinin amongst many others. PMID:27616792

  16. [Research on the citation of Herbal in Dongeuibogam].

    PubMed

    Xiao, Yongzhi; Dang, Zhizheng

    2014-07-01

    Dongeuibogam is the most prestigious traditional medical book in Korea, written by Heo Joon, who codified it by picking the essence of Chinese traditional medical books before the Ming Dynasty and some other ancient Chinese books and sorted them out. Among the citations of this book, those marked as"Herbal" is more complicated. We made a preliminary research on the citations of such Herbal, from their distribution, sources, citation manners, pharmacological features, to find that 23 rolls of main text to include citations of Herbal in each roll. We also found that most Herbal referred by Heo Joon come from Zheng lei ben cao (Classified Materia Medica), and a few of the contents are mixed with the contents of other medical books. Heo Joon abstracted and modified the citations from the source literature, embodying his ideas of pursuing conciseness and practicability. PMID:25429883

  17. Evaluating nephrotoxicity of high-molecular-weight organic compounds in drinking water from lignite aquifers

    USGS Publications Warehouse

    Bunnell, J.E.; Tatu, C.A.; Lerch, H.E.; Orem, W.H.; Pavlovic, N.

    2007-01-01

    High-molecular-weight organic compounds such as humic acids and/or fulvic acids that are naturally mobilized from lignite beds into untreated drinking-water supplies were suggested as one possible cause of Balkan endemic nephropathy (BEN) and cancer of the renal pelvis. A lab investigation was undertaken in order to assess the nephrotoxic potential of such organic compounds using an in vitro tissue culture model. Because of the infeasibility of exposing kidney tissue to low concentrations of organics for years in the lab, tangential flow ultrafiltration was employed to hyperconcentrate samples suitable for discerning effects in the short time frames necessitated by tissue culture systems. Effects on HK-2 kidney cells were measured using two different cell proliferation assays (MTT and alamarBlue). Results demonstrated that exposure of kidney tissue to high-molecular-weight organics produced excess cell death or proliferation depending on concentration and duration of exposure. Copyright ?? Taylor & Francis Group, LLC.

  18. The nucleation of austenite in ferritic ductile cast iron

    SciTech Connect

    Chou, J.M.; Hon, M.H. ); Lee, J.L. )

    1992-07-01

    Austempered ductile cast iron has recently been receiving increasing attention because of its excellent combination of strength and ductility. Since the austenitization process has a significant influence on the mechanical properties of austempered ductile cast iron, several investigations on the nucleation sites of austenite and diffusion paths of carbon from spheroidal graphite have been reported in ferritic ductile cast iron. However, agreement on this subject has not ben reached. The purpose of this paper is to study the preferential nucleation sites of austenite during austenitization at two austenitizing temperatures in ferritic ductile cast iron. An attempt was made to understand the reasons which give rise to preferential austenite nucleation sites. The carbon diffusion paths from spheroidal graphite were also investigated.

  19. TMAP [Teleoperated Mobile Antiarmor Platform]: The Army`s near term entree to battlefield robotics

    SciTech Connect

    Simmons, R.K.

    1988-05-01

    TMAP is a remotely operated battlefield system consisting of a 750-pound all terrain vehicle, remotely operated by a solider over a fiber optic communication link 4 km long. Using state-of-the-art automation and robotic technology, Martin Marietta Aero and Naval Systems is developing a modular prototype system under contract to Sandia National Laboratories. The Army Material developer is the Missile Command (MICOM) at Huntsville, Alabama; the Combat Developer is the Infantry School (USAIS) at Ft. Benning, Georgia. With the weapons removed by Congress in December 1987, the O & O is being rewritten for a ``Tactical Multipurpose Automated Platform`` (TMAP) instead of the original Teleoperated Mobile Antiarmor Platform. With minimal modification the modular TMAP system can be used in many applications (eg., antiarmor or antiair weapons, mine detection, medical support). System acceptance and Army evaluation testing is scheduled for summer and fall of 1988. 9 figs., 2 tabs.

  20. Defining and Computing a Valued Based Cyber Security Measure

    SciTech Connect

    Aissa, Anis Ben; Abercrombie, Robert K; Sheldon, Frederick T; Mili, Ali

    2011-01-01

    In earlier works (Ben-Aissa et al. 2010; Abercrombie et al. 2008; Sheldon et al. 2009), we presented a value based measure of cybersecurity that quantifies the security of a system in concrete terms, specifically, in terms of how much each system stakeholder stands to lose (in dollars per hour of operation) as a result of security threats and system vulnerabilities; our metric varies according to the stakes that each stakeholder has in meeting each security requirement. In this paper, we discuss the specification and design of a system that collects, updates, and maintains all the information that pertains to estimating our cybersecurity measure, and offers stakeholders quantitative means to make security-related decisions.