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Sample records for berkelium 243

  1. Berkelium

    NASA Astrophysics Data System (ADS)

    Hobart, David E.; Peterson, Joseph R.

    As was the case for the previously discovered transuranium elements, element 97 was first produced via a nuclear bombardment reaction. In December 1949 ion-exchange separation of the products formed by the bombardment of 241Am with accelerated alpha particles provided a new electron-capture activity eluting just ahead of curium (Thompson et al., 1950a,b). This activity was assigned to an isotope (mass number 243) of element 97. The new element was named berkelium after Berkeley, California, USA, the city of its discovery, in a manner parallel to the naming of its lanthanide analog, terbium, after Ytterby, Sweden. The initial investigations of the chemical properties of berkelium were limited to tracer experiments (ion exchange and coprecipitation), and these were sufficient to establish the stability of Bk(III) and the accessibility of Bk(IV) in aqueous solution and to estimate the electrochemical potential of the Bk(IV)/Bk(III) couple (Thompson et al., 1950b,c). Because a complete study of the chemistry of an element is not possible by tracer methods alone, a program for long-term neutron irradiation of about 8 g of 239Pu was initiated in 1952 in the Materials Testing Reactor (Arco, Idaho, USA) to provide macroquantities of berkelium (Cunningham, 1959). In 1958 about 0.6 mg of 249Bk was separated, purified, and used in experiments to determine the absorption spectrum of Bk(III) in aqueous solution and to measure the magnetic susceptibility of Bk(III) (Cunningham, 1959). No Bk(III) absorption was observed over the wavelength range 450-750 nm, but an upper limit of about 20 was set for the molar absorptivity of any Bk(III) absorption in this wavelength region. The magnetic susceptibility, measured from 77 to 298 K with the Bk(III) ions sorbed in a single bead of cation-exchange resin, was found to conform to the Curie-Weiss law with an effective moment of 8.7 mB, suggesting a 5f8 electronic configuration for the Bk(III) ion. The first structure determination of a

  2. Chemistry of berkelium

    SciTech Connect

    Peterson, J.R.; Hobart, D.E.

    1984-01-01

    The possibility of studying the physical and chemical properties of Bk(II) in bulk is intriguing. It has been suggested that this new oxidation state of berkelium is produced by nature via the ..cap alpha.. decay of einsteinium-253 dihalides; however, in these absorption spectrophotometric studies, only the divalent parent species and the divalent californium-249 granddaughter species have been directly identified. Other work has shown that the ..beta.. decay of berkelium-249 in the bulk-phase solid state results in the production of daughter californium-249 species exhibiting the same oxidation state and structural environment as those of the berkelium parent. Direct synthesis of Bk(II) via the reaction Bk + 2BkBr/sub 3/ ..-->.. 3BkBr/sub 2/ should be attempted to establish with certainty the existence of Bk(II) in the bulk-phase solid state and to characterize it via absorption spectrophotometry and X-ray powder diffraction. Studies of berkelium metal under pressure should be continued to determine more precisely its bulk modulus and to search for the existence of a distorted face-centered cubic (fcc) modification between the known fcc and ..cap alpha..-uranium-type orthorhombic phases. An interesting extension of this research would be to investigate the behavior of BkN under pressure to see if it might undergo a sudden volume collapse corresponding to a change in metallic valence from three to four. The preparation and characterization of intermetallic compounds and alloys of berkelium should be pursued, as well as the determination of the stability constants of Bk(IV) complexes. The range of oxidation states accessible to berkelium might be expanded by stabilizing Bk(II) and/or Bk(V) in highly complexing aqueous, nonaqueous, or even molten salt media and/or in appropriate solid-state matrices. 240 references, 9 figures, 5 tables.

  3. METHOD FOR THE RECOVERY AND PURIFICATION OF BERKELIUM

    DOEpatents

    Hulet, E.K.

    1959-10-20

    A solvent extraction process is described for the separation of berkelium from a mixture of elements in the lanthanum and actinium series of the periodic table. In particular, the mixture of elements is dissolved in 1.0N nitric acid, and the resulting solution is extracted with n-tributyl phosphate containlng a stoichiometric excess of solid sodium bismuthate. The berkelium present in the nitric acid solution is oxidized to the IV oxidation state and is preferentially- extracted into the n-tributyl phosphate. The organic phase, containing berkelium in an oxidized state, is extracted with 0.1N hydrochloric acid solution containing a small quantity- of a reducing agent such as yvdrazine hydrochloride. The berkelium is reduced to the III oxidation state and is extracted into the aqueous phase. The berkelium is then recovered from the aqueous phase.

  4. The New Element Berkelium (Atomic Number 97)

    DOE R&D Accomplishments Database

    Seaborg, G. T.; Thompson, S. G.; Ghiorso, A.

    1950-04-26

    An isotope of the element with atomic number 97 has been discovered as a product of the helium-ion bombardment of americium. The name berkelium, symbol Bk, is proposed for element 97. The chemical separation of element 97 from the target material and other reaction products was made by combinations of precipitation and ion exchange adsorption methods making use of its anticipated (III) and (IV) oxidation states and its position as a member of the actinide transition series. The distinctive chemical properties made use of in its separation and the equally distinctive decay properties of the particular isotope constitute the principal evidence for the new element.

  5. Characterization of berkelium(III) dipicolinate and borate compounds in solution and the solid state.

    PubMed

    Silver, Mark A; Cary, Samantha K; Johnson, Jason A; Baumbach, Ryan E; Arico, Alexandra A; Luckey, Morgan; Urban, Matthew; Wang, Jamie C; Polinski, Matthew J; Chemey, Alexander; Liu, Guokui; Chen, Kuan-Wen; Van Cleve, Shelley M; Marsh, Matthew L; Eaton, Teresa M; van de Burgt, Lambertus J; Gray, Ashley L; Hobart, David E; Hanson, Kenneth; Maron, Laurent; Gendron, Frédéric; Autschbach, Jochen; Speldrich, Manfred; Kögerler, Paul; Yang, Ping; Braley, Jenifer; Albrecht-Schmitt, Thomas E

    2016-08-26

    Berkelium is positioned at a crucial location in the actinide series between the inherently stable half-filled 5f(7) configuration of curium and the abrupt transition in chemical behavior created by the onset of a metastable divalent state that starts at californium. However, the mere 320-day half-life of berkelium's only available isotope, (249)Bk, has hindered in-depth studies of the element's coordination chemistry. Herein, we report the synthesis and detailed solid-state and solution-phase characterization of a berkelium coordination complex, Bk(III)tris(dipicolinate), as well as a chemically distinct Bk(III) borate material for comparison. We demonstrate that berkelium's complexation is analogous to that of californium. However, from a range of spectroscopic techniques and quantum mechanical calculations, it is clear that spin-orbit coupling contributes significantly to berkelium's multiconfigurational ground state. PMID:27563098

  6. Possible stabilization of the tetravalent oxidation state of berkelium and californium in acetonitrile with triphenylarsine oxide

    SciTech Connect

    Payne, G.F.; Peterson, J.R.

    1987-01-01

    It appears that we may have prepared Bk(IV) nitrate.nTPAs0 and Bk(IV) perchlorate.nTPAs0 complexes which formed the corresponding Cf(IV) complexes through the beta decay of Bk-249. Definitive proof should come from similar experiments with quantities of Bk-249 large enough to allow spectrophotometric detection of the characteristic f..-->..f transitions in these berkelium and californium species. It is clear, however, that TPAs0 and acetonitrile can play a pivotal role in the stabilization of lanact(IV) species.

  7. 48 CFR 5252.243-9000-5252.243-9001 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false 5252.243-9000-5252.243-9001 Section 5252.243-9000-5252.243-9001 Federal Acquisition Regulations System DEPARTMENT OF THE NAVY ACQUISITION REGULATIONS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of Provisions and Clauses...

  8. Nuclear Data Sheets for A=243

    DOE PAGESBeta

    Nesaraja, Caroline D; McCutchan, Elizabeth A.

    2014-09-30

    We present available information pertaining to the nuclear structure of all nuclei with mass numbers A=243. Various decay and reaction data are evaluated and compared. Adopted data, levels, spin, parity and configuration assignments are given. When there are insufficient data, expected values from systematics of nuclear properties or/and theoretical calculations are quoted. Unexpected or discrepant experimental results are also noted. A summary and compilation of the discovery of various isotopes in this mass region is given in 2013Fr02 (243Np, 243Pu, 243Am, 243Cm, 243Bk, and 243Cf), 2011Me01 (243Es), and 2013Th02 (243Fm).

  9. Geology of 243 Ida

    NASA Astrophysics Data System (ADS)

    Sullivan, R.; Greeley, R.; Pappalardo, R.; Asphaug, E.; Moore, J. M.; Morrison, D.; Belton, M. J. S.; Carr, M.; Chapman, C. R.; Geissler, P.; Greenberg, R.; Granahan, James; Head, J. W., III; Kirk, R.; McEwen, A.; Lee, P.; Thomas, P. C.; Veverka, J.

    1996-03-01

    The surface of 243 Ida is dominated by the effects of impacts. No complex crater morphologies are observed. A complete range of crater degradation states is present, which also reveals optical maturation of the surface (darkening and reddening of materials with increasing exposure age). Regions of bright material associated with the freshest craters might be ballistically emplaced deposits or the result of seismic disturbance of loosely-bound surface materials. Diameter/depth ratios for fresh craters on Ida are ∼1:6.5, similar to Gaspra results, but greater than the 1:5 ratios common on other rocky bodies. Contributing causes include rim degradation by whole-body “ringing,” relatively thin ejecta blankets around crater rims, or an extended strength gradient in near-surface materials due to low gravitational self-packing. Grooves probably represent expressions in surface debris of reactivated fractures in the deeper interior. Isolated positive relief features as large as 150 m are probably ejecta blocks related to large impacts. Evidence for the presence of debris on the surface includes resolved ejecta blocks, mass-wasting scars, contrasts in color and albedo of fresh crater materials, and albedo streaks oriented down local slopes. Color data indicate relatively uniform calcium abundance in pyroxenes and constant pyroxene/olivine ratio. A large, relatively blue unit across the northern polar area is probably related to regolith processes involving ejecta from Azzurra rather than representing internal compositional heterogeneity. A small number of bluer, brighter craters are randomly distributed across the surface, unlike on Gaspra where these features are concentrated along ridges. This implies that debris on Ida is less mobile and/or consistently thicker than on Gaspra. Estimates of the average depth of mobile materials derived from chute depths (20-60 m), grooves (≥30 m), and shallowing of the largest degraded craters (20-50 m minimum, ∼100 m maximum

  10. Geology of 243 Ida

    USGS Publications Warehouse

    Sullivan, R.; Greeley, R.; Pappalardo, R.; Asphaug, E.; Moore, Johnnie N.; Morrison, D.; Belton, M.J.S.; Carr, M.; Chapman, C.R.; Geissler, P.; Greenberg, R.; Granahan, J.; Head, J. W., III; Kirk, R.; McEwen, A.; Lee, P.; Thomas, P.C.; Veverka, J.

    1996-01-01

    The surface of 243 Ida is dominated by the effects of impacts. No complex crater morphologies are observed. A complete range of crater degradation states is present, which also reveals optical maturation of the surface (darkening and reddening of materials with increasing exposure age). Regions of bright material associated with the freshest craters might be ballistically emplaced deposits or the result of seismic disturbance of loosely-bound surface materials. Diameter/depth ratios for fresh craters on Ida are ???1:6.5, similar to Gaspra results, but greater than the 1:5 ratios common on other rocky bodies. Contributing causes include rim degradation by whole-body "ringing," relatively thin ejecta blankets around crater rims, or an extended strength gradient in near-surface materials due to low gravitational self-packing. Grooves probably represent expressions in surface debris of reactivated fractures in the deeper interior. Isolated positive relief features as large as 150 m are probably ejecta blocks related to large impacts. Evidence for the presence of debris on the surface includes resolved ejecta blocks, mass-wasting scars, contrasts in color and albedo of fresh crater materials, and albedo streaks oriented down local slopes. Color data indicate relatively uniform calcium abundance in pyroxenes and constant pyroxene/olivine ratio. A large, relatively blue unit across the northern polar area is probably related to regolith processes involving ejecta from Azzurra rather than representing internal compositional heterogeneity. A small number of bluer, brighter craters are randomly distributed across the surface, unlike on Gaspra where these features are concentrated along ridges. This implies that debris on Ida is less mobile and/or consistently thicker than on Gaspra. Estimates of the average depth of mobile materials derived from chute depths (20-60 m), grooves (???30 m), and shallowing of the largest degraded craters (20-50 m minimum, ???100 m maximum

  11. Nuclear Data Sheets for A = 243

    SciTech Connect

    Nesaraja, C.D.; McCutchan, E.A.

    2014-09-15

    Available information pertaining to the nuclear structure of all nuclei with mass numbers A=243 is presented. Various decay and reaction data are evaluated and compared. Adopted data, levels, spin, parity and configuration assignments are given. When there are insufficient data, expected values from systematics of nuclear properties or/and theoretical calculations are quoted. Unexpected or discrepant experimental results are also noted. A summary and compilation of the discovery of various isotopes in this mass region is given in 2013Fr02 ({sup 243}Np, {sup 243}Pu, {sup 243}Am, {sup 243}Cm, {sup 243}Bk, and {sup 243}Cf), 2011Me01 ({sup 243}Es), and 2013Th02 ({sup 243}Fm)

  12. Nuclear Data Sheets for A=243

    SciTech Connect

    Nesaraja, Caroline D; McCutchan, Elizabeth A.

    2014-09-30

    We present available information pertaining to the nuclear structure of all nuclei with mass numbers A=243. Various decay and reaction data are evaluated and compared. Adopted data, levels, spin, parity and configuration assignments are given. When there are insufficient data, expected values from systematics of nuclear properties or/and theoretical calculations are quoted. Unexpected or discrepant experimental results are also noted. A summary and compilation of the discovery of various isotopes in this mass region is given in 2013Fr02 (243Np, 243Pu, 243Am, 243Cm, 243Bk, and 243Cf), 2011Me01 (243Es), and 2013Th02 (243Fm).

  13. 40 CFR 243.203 - Collection frequency.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Collection frequency. 243.203 Section 243.203 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES... and Recommended Procedures § 243.203 Collection frequency....

  14. 40 CFR 243.203 - Collection frequency.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Collection frequency. 243.203 Section 243.203 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES... and Recommended Procedures § 243.203 Collection frequency....

  15. 40 CFR 243.203 - Collection frequency.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Collection frequency. 243.203 Section 243.203 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES... and Recommended Procedures § 243.203 Collection frequency....

  16. 40 CFR 243.203 - Collection frequency.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Collection frequency. 243.203 Section 243.203 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES... and Recommended Procedures § 243.203 Collection frequency....

  17. 40 CFR 243.203 - Collection frequency.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Collection frequency. 243.203 Section 243.203 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES... and Recommended Procedures § 243.203 Collection frequency....

  18. 46 CFR 169.243 - Electrical.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Electrical. 169.243 Section 169.243 Shipping COAST GUARD... Certification Inspections § 169.243 Electrical. At each inspection for certification and periodic inspection... that they are in proper operating condition, in safe electrical condition, and fit for the service...

  19. 46 CFR 169.243 - Electrical.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Electrical. 169.243 Section 169.243 Shipping COAST GUARD... Certification Inspections § 169.243 Electrical. At each inspection for certification and periodic inspection... that they are in proper operating condition, in safe electrical condition, and fit for the service...

  20. 46 CFR 169.243 - Electrical.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Electrical. 169.243 Section 169.243 Shipping COAST GUARD... Certification Inspections § 169.243 Electrical. At each inspection for certification and periodic inspection... that they are in proper operating condition, in safe electrical condition, and fit for the service...

  1. 46 CFR 169.243 - Electrical.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Electrical. 169.243 Section 169.243 Shipping COAST GUARD... Certification Inspections § 169.243 Electrical. At each inspection for certification and periodic inspection... that they are in proper operating condition, in safe electrical condition, and fit for the service...

  2. 46 CFR 169.243 - Electrical.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Electrical. 169.243 Section 169.243 Shipping COAST GUARD... Certification Inspections § 169.243 Electrical. At each inspection for certification and periodic inspection... that they are in proper operating condition, in safe electrical condition, and fit for the service...

  3. 40 CFR 243.201 - Safety.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Safety. 243.201 Section 243.201 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE STORAGE... Procedures § 243.201 Safety....

  4. 40 CFR 243.201 - Safety.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Safety. 243.201 Section 243.201 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE STORAGE... Procedures § 243.201 Safety....

  5. 40 CFR 243.201 - Safety.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Safety. 243.201 Section 243.201 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE STORAGE... Procedures § 243.201 Safety....

  6. 40 CFR 243.201 - Safety.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Safety. 243.201 Section 243.201 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE STORAGE... Procedures § 243.201 Safety....

  7. 40 CFR 243.204 - Collection management.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Collection management. 243.204 Section 243.204 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES... and Recommended Procedures § 243.204 Collection management....

  8. 40 CFR 243.204 - Collection management.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Collection management. 243.204 Section 243.204 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES... and Recommended Procedures § 243.204 Collection management....

  9. 40 CFR 243.204 - Collection management.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Collection management. 243.204 Section 243.204 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES... and Recommended Procedures § 243.204 Collection management....

  10. 40 CFR 243.204 - Collection management.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Collection management. 243.204 Section 243.204 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES... and Recommended Procedures § 243.204 Collection management....

  11. 40 CFR 243.204 - Collection management.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Collection management. 243.204 Section 243.204 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES... and Recommended Procedures § 243.204 Collection management....

  12. 40 CFR 243.100 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Scope. 243.100 Section 243.100 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE STORAGE AND COLLECTION OF RESIDENTIAL, COMMERCIAL, AND INSTITUTIONAL SOLID WASTE General Provisions § 243.100 Scope. (a) These guidelines are...

  13. 40 CFR 243.100 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Scope. 243.100 Section 243.100 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE STORAGE AND COLLECTION OF RESIDENTIAL, COMMERCIAL, AND INSTITUTIONAL SOLID WASTE General Provisions § 243.100 Scope. (a) These guidelines are...

  14. 14 CFR 243.1 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Purpose. 243.1 Section 243.1 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS PASSENGER MANIFEST INFORMATION § 243.1 Purpose. The purpose of this part is to ensure that the...

  15. 14 CFR 243.13 - Filing requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Filing requirements. 243.13 Section 243.13 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS PASSENGER MANIFEST INFORMATION § 243.13 Filing requirements. (a) Each covered airline...

  16. 14 CFR 243.5 - Applicability.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Applicability. 243.5 Section 243.5 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS PASSENGER MANIFEST INFORMATION § 243.5 Applicability. This part applies to covered flight...

  17. 14 CFR 243.17 - Enforcement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Enforcement. 243.17 Section 243.17 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS PASSENGER MANIFEST INFORMATION § 243.17 Enforcement. The U.S. Department of Transportation may...

  18. 42 CFR 24.3 - Policy Board.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Policy Board. 24.3 Section 24.3 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.3 Policy Board. The Secretary or his/her designee shall establish an SBRS Policy Board...

  19. 42 CFR 24.3 - Policy Board.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Policy Board. 24.3 Section 24.3 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.3 Policy Board. The Secretary or his/her designee shall establish an SBRS Policy Board...

  20. 48 CFR 243.204 - Administration.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Administration. 243.204... OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204 Administration. Follow the procedures at PGI 243.204 for administration of change orders....

  1. 48 CFR 243.204 - Administration.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Administration. 243.204... OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204 Administration. Follow the procedures at PGI 243.204 for administration of change orders....

  2. 48 CFR 243.204 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Administration. 243.204... OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204 Administration. Follow the procedures at PGI 243.204 for administration of change orders....

  3. 48 CFR 243.204 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Administration. 243.204... OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204 Administration. Follow the procedures at PGI 243.204 for administration of change orders....

  4. 40 CFR 243.203-1 - Requirement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Requirement. 243.203-1 Section 243.203-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE STORAGE AND COLLECTION OF RESIDENTIAL, COMMERCIAL, AND INSTITUTIONAL SOLID WASTE Requirements and Recommended Procedures § 243.203-1...

  5. 33 CFR 117.243 - Nanticoke River.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Nanticoke River. 117.243 Section 117.243 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Delaware § 117.243 Nanticoke River. (a) The draw...

  6. 33 CFR 117.243 - Nanticoke River.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Nanticoke River. 117.243 Section 117.243 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Delaware § 117.243 Nanticoke River. (a) The draw...

  7. 33 CFR 117.243 - Nanticoke River.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Nanticoke River. 117.243 Section 117.243 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Delaware § 117.243 Nanticoke River. (a) The draw...

  8. 33 CFR 117.243 - Nanticoke River.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Nanticoke River. 117.243 Section 117.243 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Delaware § 117.243 Nanticoke River. (a) The draw...

  9. 33 CFR 117.243 - Nanticoke River.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Nanticoke River. 117.243 Section 117.243 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Delaware § 117.243 Nanticoke River. (a) The draw...

  10. 7 CFR 58.243 - Checking quality.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Checking quality. 58.243 Section 58.243 Agriculture... Procedures § 58.243 Checking quality. All milk, milk products and dry milk products shall be subject to inspection and analysis by the dairy plant for quality and condition throughout each processing...

  11. 14 CFR 243.5 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Applicability. 243.5 Section 243.5 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS PASSENGER MANIFEST INFORMATION § 243.5 Applicability. This part applies to covered flight...

  12. 14 CFR 243.5 - Applicability.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Applicability. 243.5 Section 243.5 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS PASSENGER MANIFEST INFORMATION § 243.5 Applicability. This part applies to covered flight...

  13. 14 CFR 243.5 - Applicability.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Applicability. 243.5 Section 243.5 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS PASSENGER MANIFEST INFORMATION § 243.5 Applicability. This part applies to covered flight...

  14. 14 CFR 243.5 - Applicability.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Applicability. 243.5 Section 243.5 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS PASSENGER MANIFEST INFORMATION § 243.5 Applicability. This part applies to covered flight...

  15. 40 CFR 408.243 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 30 2012-07-01 2012-07-01 false 408.243 Section 408.243 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS CANNED AND PRESERVED SEAFOOD PROCESSING POINT SOURCE CATEGORY Mechanized Clam Processing Subcategory § 408.243...

  16. 40 CFR 408.243 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 29 2011-07-01 2009-07-01 true 408.243 Section 408.243 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS CANNED AND PRESERVED SEAFOOD PROCESSING POINT SOURCE CATEGORY Mechanized Clam Processing Subcategory § 408.243...

  17. 40 CFR 408.243 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true 408.243 Section 408.243 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS CANNED AND PRESERVED SEAFOOD PROCESSING POINT SOURCE CATEGORY Mechanized Clam Processing Subcategory § 408.243...

  18. 40 CFR 408.243 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 30 2013-07-01 2012-07-01 true 408.243 Section 408.243 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS CANNED AND PRESERVED SEAFOOD PROCESSING POINT SOURCE CATEGORY Mechanized Clam Processing Subcategory § 408.243...

  19. 40 CFR 408.243 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 29 2014-07-01 2012-07-01 true 408.243 Section 408.243 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS CANNED AND PRESERVED SEAFOOD PROCESSING POINT SOURCE CATEGORY Mechanized Clam Processing Subcategory § 408.243...

  20. 42 CFR 24.3 - Policy Board.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Policy Board. 24.3 Section 24.3 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.3 Policy Board. The Secretary or his/her designee shall establish an SBRS Policy Board...

  1. 42 CFR 24.3 - Policy Board.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Policy Board. 24.3 Section 24.3 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.3 Policy Board. The Secretary or his/her designee shall establish an SBRS Policy Board...

  2. 42 CFR 24.3 - Policy Board.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Policy Board. 24.3 Section 24.3 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.3 Policy Board. The Secretary or his/her designee shall establish an SBRS Policy Board...

  3. 14 CFR 16.243 - Consent orders.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Consent orders. 16.243 Section 16.243... PRACTICE FOR FEDERALLY-ASSISTED AIRPORT ENFORCEMENT PROCEEDINGS Hearings § 16.243 Consent orders. (a) The... order to dispose of the case by issuance of a consent order. Good faith efforts to resolve a...

  4. 27 CFR 24.243 - Filtering aids.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Filtering aids. 24.243... OF THE TREASURY LIQUORS WINE Storage, Treatment and Finishing of Wine § 24.243 Filtering aids. Inert fibers, pulps, earths, or similar materials, may be used as filtering aids in the cellar treatment...

  5. 27 CFR 24.243 - Filtering aids.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Filtering aids. 24.243... OF THE TREASURY ALCOHOL WINE Storage, Treatment and Finishing of Wine § 24.243 Filtering aids. Inert fibers, pulps, earths, or similar materials, may be used as filtering aids in the cellar treatment...

  6. 27 CFR 24.243 - Filtering aids.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Filtering aids. 24.243... OF THE TREASURY LIQUORS WINE Storage, Treatment and Finishing of Wine § 24.243 Filtering aids. Inert fibers, pulps, earths, or similar materials, may be used as filtering aids in the cellar treatment...

  7. 27 CFR 24.243 - Filtering aids.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Filtering aids. 24.243... OF THE TREASURY LIQUORS WINE Storage, Treatment and Finishing of Wine § 24.243 Filtering aids. Inert fibers, pulps, earths, or similar materials, may be used as filtering aids in the cellar treatment...

  8. 27 CFR 24.243 - Filtering aids.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Filtering aids. 24.243... OF THE TREASURY ALCOHOL WINE Storage, Treatment and Finishing of Wine § 24.243 Filtering aids. Inert fibers, pulps, earths, or similar materials, may be used as filtering aids in the cellar treatment...

  9. 37 CFR 2.43 - Service mark.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2012-07-01 2012-07-01 false Service mark. 2.43 Section 2... COMMERCE RULES OF PRACTICE IN TRADEMARK CASES The Written Application § 2.43 Service mark. In an application to register a service mark, the application shall specify and contain all the elements required...

  10. 37 CFR 2.43 - Service mark.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Service mark. 2.43 Section 2... COMMERCE RULES OF PRACTICE IN TRADEMARK CASES The Written Application § 2.43 Service mark. In an application to register a service mark, the application shall specify and contain all the elements required...

  11. 37 CFR 2.43 - Service mark.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2013-07-01 2013-07-01 false Service mark. 2.43 Section 2... COMMERCE RULES OF PRACTICE IN TRADEMARK CASES The Written Application § 2.43 Service mark. In an application to register a service mark, the application shall specify and contain all the elements required...

  12. 37 CFR 2.43 - Service mark.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2011-07-01 2011-07-01 false Service mark. 2.43 Section 2... COMMERCE RULES OF PRACTICE IN TRADEMARK CASES The Written Application § 2.43 Service mark. In an application to register a service mark, the application shall specify and contain all the elements required...

  13. 37 CFR 2.43 - Service mark.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Service mark. 2.43 Section 2... COMMERCE RULES OF PRACTICE IN TRADEMARK CASES The Written Application § 2.43 Service mark. In an application to register a service mark, the application shall specify and contain all the elements required...

  14. 48 CFR 2152.243-70 - Changes.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Changes. 2152.243-70... CONTRACT CLAUSES Text of Provisions and Clauses 2152.243-70 Changes. As prescribed in 2143.205, insert the following clause: Changes (OCT 2005) (a) Except as provided in paragraph (f) of this clause, the...

  15. 48 CFR 52.243-4 - Changes.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Changes. 52.243-4 Section... AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 52.243-4 Changes... agency procedures. Changes (JUN 2007) (a) The Contracting Officer may, at any time, without notice to...

  16. 48 CFR 2152.243-70 - Changes.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Changes. 2152.243-70... CONTRACT CLAUSES Text of Provisions and Clauses 2152.243-70 Changes. As prescribed in 2143.205, insert the following clause: Changes (OCT 2005) (a) Except as provided in paragraph (f) of this clause, the...

  17. 48 CFR 52.243-4 - Changes.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false Changes. 52.243-4 Section... AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 52.243-4 Changes... agency procedures. Changes (JUN 2007) (a) The Contracting Officer may, at any time, without notice to...

  18. 48 CFR 52.243-4 - Changes.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 2 2012-10-01 2012-10-01 false Changes. 52.243-4 Section... AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 52.243-4 Changes... agency procedures. Changes (JUN 2007) (a) The Contracting Officer may, at any time, without notice to...

  19. 48 CFR 2152.243-70 - Changes.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Changes. 2152.243-70... CONTRACT CLAUSES Text of Provisions and Clauses 2152.243-70 Changes. As prescribed in 2143.205, insert the following clause: Changes (OCT 2005) (a) Except as provided in paragraph (f) of this clause, the...

  20. 48 CFR 52.243-4 - Changes.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 2 2014-10-01 2014-10-01 false Changes. 52.243-4 Section... AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 52.243-4 Changes... agency procedures. Changes (JUN 2007) (a) The Contracting Officer may, at any time, without notice to...

  1. 48 CFR 52.243-4 - Changes.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false Changes. 52.243-4 Section... AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 52.243-4 Changes... agency procedures. Changes (JUN 2007) (a) The Contracting Officer may, at any time, without notice to...

  2. 48 CFR 2152.243-70 - Changes.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Changes. 2152.243-70... CONTRACT CLAUSES Text of Provisions and Clauses 2152.243-70 Changes. As prescribed in 2143.205, insert the following clause: Changes (OCT 2005) (a) Except as provided in paragraph (f) of this clause, the...

  3. 49 CFR 192.243 - Nondestructive testing.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Nondestructive testing. 192.243 Section 192.243 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF NATURAL AND OTHER GAS BY PIPELINE:...

  4. 49 CFR 192.243 - Nondestructive testing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Nondestructive testing. 192.243 Section 192.243 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF NATURAL AND OTHER GAS BY PIPELINE:...

  5. 40 CFR 243.200 - Storage.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Storage. 243.200 Section 243.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE STORAGE AND COLLECTION OF RESIDENTIAL, COMMERCIAL, AND INSTITUTIONAL SOLID WASTE Requirements and...

  6. 40 CFR 243.201 - Safety.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Safety. 243.201 Section 243.201 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE STORAGE AND COLLECTION OF RESIDENTIAL, COMMERCIAL, AND INSTITUTIONAL SOLID WASTE Requirements and...

  7. 27 CFR 70.243 - Exempt amount.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2014-04-01 2014-04-01 false Exempt amount. 70.243 Section 70.243 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT... as wages, salary, or other income for each payroll period described in § 70.244 of this part...

  8. 27 CFR 70.243 - Exempt amount.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Exempt amount. 70.243 Section 70.243 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT... as wages, salary, or other income for each payroll period described in § 70.244 of this part...

  9. 27 CFR 70.243 - Exempt amount.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2011-04-01 2011-04-01 false Exempt amount. 70.243 Section 70.243 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT... as wages, salary, or other income for each payroll period described in § 70.244 of this part...

  10. 27 CFR 70.243 - Exempt amount.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2013-04-01 2013-04-01 false Exempt amount. 70.243 Section 70.243 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT... as wages, salary, or other income for each payroll period described in § 70.244 of this part...

  11. 27 CFR 70.243 - Exempt amount.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2012-04-01 2011-04-01 true Exempt amount. 70.243 Section 70.243 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT... as wages, salary, or other income for each payroll period described in § 70.244 of this part...

  12. 14 CFR 243.3 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... REGULATIONS PASSENGER MANIFEST INFORMATION § 243.3 Definitions. Air piracy means any seizure of or exercise of... piracy. Contact means a person not on the covered flight or an entity that should be contacted in case...

  13. 14 CFR 243.3 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... REGULATIONS PASSENGER MANIFEST INFORMATION § 243.3 Definitions. Air piracy means any seizure of or exercise of... piracy. Contact means a person not on the covered flight or an entity that should be contacted in case...

  14. 12 CFR 243.2 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Company Act, as amended (12 U.S.C. 1841), and the Board's Regulation Y (12 CFR part 225), that has $50... 12 Banks and Banking 4 2014-01-01 2014-01-01 false Definitions. 243.2 Section 243.2 Banks and... Financial Stability Oversight Council established by section 111 of the Dodd-Frank Act (12 U.S.C. 5321)....

  15. 12 CFR 243.2 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Company Act, as amended (12 U.S.C. 1841), and the Board's Regulation Y (12 CFR part 225), that has $50... 12 Banks and Banking 4 2012-01-01 2012-01-01 false Definitions. 243.2 Section 243.2 Banks and... Financial Stability Oversight Council established by section 111 of the Dodd-Frank Act (12 U.S.C. 5321)....

  16. Galileo 243 Ida System Spectral Observations Revisited

    NASA Astrophysics Data System (ADS)

    Granahan, J. C.

    2001-11-01

    On August 28, 1993 the Galileo spacecraft encountered the asteroid 243 Ida and its moon Dactyl. A variety of observations of this asteroid system were collected including visible wavelength (0.4-1.0 microns) imagery with the Solid State Imager (SSI) instrument and infrared wavelength (0.7-5.2 microns) with the Near Infrared Mapping Spectrometer (NIMS). A new analysis of these observations has been conducted using band area analysis, band center measurement, and spectral similarity value measurement using the BAE SYSTEMS Hyperspectral Tool Kit. This abstract reports the initial results of this research effort. These data indicate that 243 Ida has an orthopyroxene/(orthopyroxene + olivine) ratio of about 0.28, a value consistent with that of LL chondrites. The ratio does not vary significantly for the portions of 243 Ida observed by the Galileo NIMS instrument. 243 Ida is a SIV subtype of the S type asteroid population. At least two spectral units were identified in a combined SSI and NIMS spectral data set. The primary difference is the amount of red slope present in the two spectral units. A larger red slope corresponds to regions of 243 Ida where ejecta from the crater Azurra are present. This evidence suggests that impacts enhance the red components of the 243 Ida spectrum, perhaps enhancing the NiFe content. Dactyl has a relatively deep absorption centered approximately at 0.97 microns with no significant two micron absorption features. This is a possible indicator of clinopyroxene and suggests partial melting or fractional crystallization processes occurred on Dactyl. Dactyl appears to be an SII subtype S type asteroid and is spectrally different from 243 Ida. Dactyl may have been produced by partial melting within the Koronis parent body while the 243 Ida region escaped such igneous processing. This study was made possible through support from NASA's Planetary Geology and Geophysics program.

  17. 50 CFR 622.243 - Gear identification.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ADMINISTRATION, DEPARTMENT OF COMMERCE FISHERIES OF THE CARIBBEAN, GULF OF MEXICO, AND SOUTH ATLANTIC Golden Crab Fishery of the South Atlantic Region § 622.243 Gear identification. (a) Golden crab traps and associated buoys—(1) Golden crab traps. A golden crab trap used or possessed in the South Atlantic EEZ or on...

  18. 50 CFR 622.243 - Gear identification.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... ADMINISTRATION, DEPARTMENT OF COMMERCE FISHERIES OF THE CARIBBEAN, GULF OF MEXICO, AND SOUTH ATLANTIC Golden Crab Fishery of the South Atlantic Region § 622.243 Gear identification. (a) Golden crab traps and associated buoys—(1) Golden crab traps. A golden crab trap used or possessed in the South Atlantic EEZ or on...

  19. 40 CFR 243.100 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... AND COLLECTION OF RESIDENTIAL, COMMERCIAL, AND INSTITUTIONAL SOLID WASTE General Provisions § 243.100 Scope. (a) These guidelines are promulgated in partial fulfillment of section 209(a) of the Solid Waste..., commercial, and institutional solid wastes and street wastes. Explicitly excluded are mining,...

  20. 40 CFR 243.100 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... AND COLLECTION OF RESIDENTIAL, COMMERCIAL, AND INSTITUTIONAL SOLID WASTE General Provisions § 243.100 Scope. (a) These guidelines are promulgated in partial fulfillment of section 209(a) of the Solid Waste..., commercial, and institutional solid wastes and street wastes. Explicitly excluded are mining,...

  1. 49 CFR 192.243 - Nondestructive testing.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Welding of Steel in Pipelines § 192.243 Nondestructive... welder whose work is isolated from the principal welding activity, a sample of each welder's work...

  2. 49 CFR 192.243 - Nondestructive testing.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Welding of Steel in Pipelines § 192.243 Nondestructive... welder whose work is isolated from the principal welding activity, a sample of each welder's work...

  3. 49 CFR 192.243 - Nondestructive testing.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Welding of Steel in Pipelines § 192.243 Nondestructive... welder whose work is isolated from the principal welding activity, a sample of each welder's work...

  4. 15 CFR 24.3 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... least include all equipment defined above. Expenditure report means: (1) For nonconstruction grants, the SF-269 “Financial Status Report” (or other equivalent report); (2) for construction grants, the SF... GRANTS AND COOPERATIVE AGREEMENTS TO STATE AND LOCAL GOVERNMENTS General § 24.3 Definitions. As used...

  5. 15 CFR 24.3 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... least include all equipment defined above. Expenditure report means: (1) For nonconstruction grants, the SF-269 “Financial Status Report” (or other equivalent report); (2) for construction grants, the SF... GRANTS AND COOPERATIVE AGREEMENTS TO STATE AND LOCAL GOVERNMENTS General § 24.3 Definitions. As used...

  6. 15 CFR 24.3 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... least include all equipment defined above. Expenditure report means: (1) For nonconstruction grants, the SF-269 “Financial Status Report” (or other equivalent report); (2) for construction grants, the SF... GRANTS AND COOPERATIVE AGREEMENTS TO STATE AND LOCAL GOVERNMENTS General § 24.3 Definitions. As used...

  7. 14 CFR 243.13 - Filing requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... REGULATIONS PASSENGER MANIFEST INFORMATION § 243.13 Filing requirements. (a) Each covered airline that... include a contact at the covered airline, available at any time the covered airline is operating a covered... covered airline shall file any contact change as well as a description of any significant change in...

  8. 28 CFR 2.43 - Early termination.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., YOUTH OFFENDERS, AND JUVENILE DELINQUENTS United States Code Prisoners and Parolees § 2.43 Early... score in the very good risk category and has completed two continuous years of supervision free from an incident of new criminal behavior or serious parole violation; or (ii) Has a salient factor score in a...

  9. 40 CFR 243.100 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... AND COLLECTION OF RESIDENTIAL, COMMERCIAL, AND INSTITUTIONAL SOLID WASTE General Provisions § 243.100 Scope. (a) These guidelines are promulgated in partial fulfillment of section 209(a) of the Solid Waste... required of solid waste collection operations. Under section 211 of the Solid Waste Disposal Act,...

  10. 27 CFR 44.243 - Bond required.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Section 44.243 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY (CONTINUED) TOBACCO EXPORTATION OF TOBACCO PRODUCTS AND CIGARETTE PAPERS AND TUBES, WITHOUT PAYMENT OF TAX, OR WITH DRAWBACK OF TAX Withdrawal of Cigars From Customs Warehouses Bonds §...

  11. 48 CFR 243.205-70 - Pricing of contract modifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Pricing of contract modifications. 243.205-70 Section 243.205-70 Federal Acquisition Regulations System DEFENSE ACQUISITION... Pricing of contract modifications. Use the clause at 252.243-7001, Pricing of Contract Modifications,...

  12. 48 CFR 243.205-70 - Pricing of contract modifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Pricing of contract modifications. 243.205-70 Section 243.205-70 Federal Acquisition Regulations System DEFENSE ACQUISITION... Pricing of contract modifications. Use the clause at 252.243-7001, Pricing of Contract Modifications,...

  13. 48 CFR 243.205-70 - Pricing of contract modifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Pricing of contract modifications. 243.205-70 Section 243.205-70 Federal Acquisition Regulations System DEFENSE ACQUISITION... Pricing of contract modifications. Use the clause at 252.243-7001, Pricing of Contract Modifications,...

  14. 48 CFR 243.205-70 - Pricing of contract modifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Pricing of contract modifications. 243.205-70 Section 243.205-70 Federal Acquisition Regulations System DEFENSE ACQUISITION... Pricing of contract modifications. Use the clause at 252.243-7001, Pricing of Contract Modifications,...

  15. 48 CFR 243.205-70 - Pricing of contract modifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Pricing of contract modifications. 243.205-70 Section 243.205-70 Federal Acquisition Regulations System DEFENSE ACQUISITION... Pricing of contract modifications. Use the clause at 252.243-7001, Pricing of Contract Modifications,...

  16. 26 CFR 1.243-5 - Effect of election.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 3 2010-04-01 2010-04-01 false Effect of election. 1.243-5 Section 1.243-5...) INCOME TAXES Special Deductions for Corporations § 1.243-5 Effect of election. (a) General—(1... tax for each corporation, unless a different apportionment of the $100,000 amount is adopted...

  17. 26 CFR 1.243-5 - Effect of election.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 3 2011-04-01 2011-04-01 false Effect of election. 1.243-5 Section 1.243-5...) INCOME TAXES (CONTINUED) Special Deductions for Corporations § 1.243-5 Effect of election. (a) General—(1... tax for each corporation, unless a different apportionment of the $100,000 amount is adopted...

  18. 47 CFR 90.243 - Mobile relay stations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... § 90.35(b)(3), each mobile relay station, regardless of the frequency or frequencies of the signal by... 47 Telecommunication 5 2011-10-01 2011-10-01 false Mobile relay stations. 90.243 Section 90.243... MOBILE RADIO SERVICES Non-Voice and Other Specialized Operations § 90.243 Mobile relay stations....

  19. 47 CFR 90.243 - Mobile relay stations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... § 90.35(b)(3), each mobile relay station, regardless of the frequency or frequencies of the signal by... 47 Telecommunication 5 2014-10-01 2014-10-01 false Mobile relay stations. 90.243 Section 90.243... MOBILE RADIO SERVICES Non-Voice and Other Specialized Operations § 90.243 Mobile relay stations....

  20. 26 CFR 1.243-5 - Effect of election.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 3 2012-04-01 2012-04-01 false Effect of election. 1.243-5 Section 1.243-5...) INCOME TAXES (CONTINUED) Special Deductions for Corporations § 1.243-5 Effect of election. (a) General—(1) Corporations subject to restrictions and limitations. If an election by an affiliated group under section...

  1. 48 CFR 243.204-70 - Definitization of change orders.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Definitization of change orders. 243.204-70 Section 243.204-70 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204-70 Definitization of change...

  2. 48 CFR 243.205-72 - Unpriced change orders.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Unpriced change orders. 243.205-72 Section 243.205-72 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.205-72 Unpriced change orders. See the clause...

  3. 25 CFR 243.3 - Delegation of authority.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Delegation of authority. 243.3 Section 243.3 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.3... claims of ownership of reindeer in Alaska, as required by the Act (section 500b), must be filed with...

  4. 25 CFR 243.3 - Delegation of authority.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Delegation of authority. 243.3 Section 243.3 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.3... claims of ownership of reindeer in Alaska, as required by the Act (section 500b), must be filed with...

  5. 25 CFR 243.3 - Delegation of authority.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Delegation of authority. 243.3 Section 243.3 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.3... claims of ownership of reindeer in Alaska, as required by the Act (section 500b), must be filed with...

  6. 25 CFR 243.3 - Delegation of authority.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Delegation of authority. 243.3 Section 243.3 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.3... claims of ownership of reindeer in Alaska, as required by the Act (section 500b), must be filed with...

  7. 25 CFR 243.3 - Delegation of authority.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true Delegation of authority. 243.3 Section 243.3 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.3... claims of ownership of reindeer in Alaska, as required by the Act (section 500b), must be filed with...

  8. 40 CFR 243.202-2 - Recommended procedures: Design.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Recommended procedures: Design. 243.202-2 Section 243.202-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID... WASTE Requirements and Recommended Procedures § 243.202-2 Recommended procedures: Design. (a)...

  9. 48 CFR 1852.243-70 - Engineering change proposals.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Engineering change proposals. 1852.243-70 Section 1852.243-70 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND... and Clauses 1852.243-70 Engineering change proposals. As prescribed in 1843.205-70(a)(1), insert...

  10. 48 CFR 1852.243-70 - Engineering change proposals.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Engineering change proposals. 1852.243-70 Section 1852.243-70 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND... and Clauses 1852.243-70 Engineering change proposals. As prescribed in 1843.205-70(a)(1), insert...

  11. 48 CFR 1852.243-70 - Engineering change proposals.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Engineering change proposals. 1852.243-70 Section 1852.243-70 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND... and Clauses 1852.243-70 Engineering change proposals. As prescribed in 1843.205-70(a)(1), insert...

  12. 48 CFR 1852.243-70 - Engineering change proposals.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Engineering change proposals. 1852.243-70 Section 1852.243-70 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND... and Clauses 1852.243-70 Engineering change proposals. As prescribed in 1843.205-70(a)(1), insert...

  13. 14 CFR 243.7 - Information collection requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Information collection requirements. 243.7 Section 243.7 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS PASSENGER MANIFEST INFORMATION § 243.7 Information collection...

  14. 29 CFR 1910.243 - Guarding of portable powered tools.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 5 2010-07-01 2010-07-01 false Guarding of portable powered tools. 1910.243 Section 1910.243 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OCCUPATIONAL SAFETY AND HEALTH STANDARDS Hand and Portable Powered Tools and Other Hand-Held Equipment § 1910.243 Guarding...

  15. 12 CFR 303.243 - Brokered deposit waivers.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Brokered deposit waivers. 303.243 Section 303.243 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE FILING PROCEDURES Other Filings § 303.243 Brokered deposit waivers. (a) Scope. Pursuant to section 29 of the FDI...

  16. 12 CFR 243.3 - Resolution plan required.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 4 2013-01-01 2013-01-01 false Resolution plan required. 243.3 Section 243.3... (CONTINUED) RESOLUTION PLANS § 243.3 Resolution plan required. (a) Initial and annual resolution plans... Corporation on or before the date set forth below (“Initial Submission Date”): (i) July 1, 2012, with...

  17. 40 CFR 98.243 - Calculating GHG emissions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 21 2014-07-01 2014-07-01 false Calculating GHG emissions. 98.243 Section 98.243 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Petrochemical Production § 98.243 Calculating GHG emissions. (a) If you route all process vent emissions...

  18. 12 CFR 19.243 - Removal, suspension, or debarment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Removal, suspension, or debarment. 19.243 Section 19.243 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY RULES OF PRACTICE AND PROCEDURE Removal, Suspension, and Debarment of Accountants From Performing Audit Services § 19.243 Removal, suspension, or debarment. (a)...

  19. 20 CFR 243.4 - Taxation of benefits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Taxation of benefits. 243.4 Section 243.4 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT TRANSFER, ASSIGNMENT, OR WAIVER OF PAYMENTS § 243.4 Taxation of benefits. (a) Annuities paid by the Board are...

  20. 20 CFR 243.4 - Taxation of benefits.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false Taxation of benefits. 243.4 Section 243.4 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT TRANSFER, ASSIGNMENT, OR WAIVER OF PAYMENTS § 243.4 Taxation of benefits. (a) Annuities paid by the Board are...

  1. 20 CFR 243.4 - Taxation of benefits.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true Taxation of benefits. 243.4 Section 243.4 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT TRANSFER, ASSIGNMENT, OR WAIVER OF PAYMENTS § 243.4 Taxation of benefits. (a) Annuities paid by the Board are...

  2. 12 CFR 24.3 - Public welfare investments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... investment would receive consideration under 12 CFR 25.23 as a “qualified investment.” ... 12 Banks and Banking 1 2011-01-01 2011-01-01 false Public welfare investments. 24.3 Section 24.3... DEVELOPMENT ENTITIES, COMMUNITY DEVELOPMENT PROJECTS, AND OTHER PUBLIC WELFARE INVESTMENTS § 24.3...

  3. 12 CFR 24.3 - Public welfare investments.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... investment would receive consideration under 12 CFR 25.23 as a “qualified investment.” ... 12 Banks and Banking 1 2013-01-01 2013-01-01 false Public welfare investments. 24.3 Section 24.3... DEVELOPMENT ENTITIES, COMMUNITY DEVELOPMENT PROJECTS, AND OTHER PUBLIC WELFARE INVESTMENTS § 24.3...

  4. 12 CFR 24.3 - Public welfare investments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... investment would receive consideration under 12 CFR 25.23 as a “qualified investment.” ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Public welfare investments. 24.3 Section 24.3... DEVELOPMENT ENTITIES, COMMUNITY DEVELOPMENT PROJECTS, AND OTHER PUBLIC WELFARE INVESTMENTS § 24.3...

  5. 12 CFR 24.3 - Public welfare investments.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... investment would receive consideration under 12 CFR 25.23 as a “qualified investment.” ... 12 Banks and Banking 1 2014-01-01 2014-01-01 false Public welfare investments. 24.3 Section 24.3... DEVELOPMENT ENTITIES, COMMUNITY DEVELOPMENT PROJECTS, AND OTHER PUBLIC WELFARE INVESTMENTS § 24.3...

  6. 12 CFR 24.3 - Public welfare investments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... investment would receive consideration under 12 CFR 25.23 as a “qualified investment.” ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Public welfare investments. 24.3 Section 24.3... DEVELOPMENT ENTITIES, COMMUNITY DEVELOPMENT PROJECTS, AND OTHER PUBLIC WELFARE INVESTMENTS § 24.3...

  7. 40 CFR 421.242-421.243 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true 421.242-421.243 Section 421.242-421.243 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS NONFERROUS METALS MANUFACTURING POINT SOURCE CATEGORY Secondary Nickel Subcategory §§ 421.242-421.243...

  8. 40 CFR 421.242-421.243 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 30 2013-07-01 2012-07-01 true 421.242-421.243 Section 421.242-421.243 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS NONFERROUS METALS MANUFACTURING POINT SOURCE CATEGORY Secondary Nickel Subcategory §§ 421.242-421.243...

  9. 40 CFR 421.242-421.243 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 29 2011-07-01 2009-07-01 true 421.242-421.243 Section 421.242-421.243 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS NONFERROUS METALS MANUFACTURING POINT SOURCE CATEGORY Secondary Nickel Subcategory §§ 421.242-421.243...

  10. 40 CFR 421.242-421.243 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 29 2014-07-01 2012-07-01 true 421.242-421.243 Section 421.242-421.243 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS NONFERROUS METALS MANUFACTURING POINT SOURCE CATEGORY Secondary Nickel Subcategory §§ 421.242-421.243...

  11. 48 CFR 243.204-70-6 - Allowable profit.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Allowable profit. 243.204-70-6 Section 243.204-70-6 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204-70-6 Allowable profit. When the final price of an...

  12. 40 CFR Appendix to Part 243 - Recommended Bibliography

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Recommended Bibliography Appendix to Part 243 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE STORAGE AND COLLECTION OF RESIDENTIAL, COMMERCIAL, AND INSTITUTIONAL SOLID WASTE Pt. 243, App. Appendix to Part 243—Recommended...

  13. 20 CFR 243.1 - Prohibition against garnishment.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Prohibition against garnishment. 243.1 Section 243.1 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT TRANSFER, ASSIGNMENT, OR WAIVER OF PAYMENTS § 243.1 Prohibition against garnishment. Except as...

  14. 47 CFR 90.243 - Mobile relay stations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Mobile relay stations. 90.243 Section 90.243... MOBILE RADIO SERVICES Non-Voice and Other Specialized Operations § 90.243 Mobile relay stations. (a) Mobile relay operations will be authorized on frequencies below 512 MHz, except in the...

  15. 40 CFR 180.243 - Propazine; tolerances for residues.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .... 180.243 Section 180.243 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... § 180.243 Propazine; tolerances for residues. (a) General. Tolerances are established for residues of... Sorghum, grain, stover 0.25 (b) Section 18 emergency exemptions. (c) Tolerances with...

  16. 40 CFR 243.202-2 - Recommended procedures: Design.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Recommended procedures: Design. 243.202-2 Section 243.202-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID... WASTE Requirements and Recommended Procedures § 243.202-2 Recommended procedures: Design. (a)...

  17. First Galileo image of asteroid 243 Ida

    NASA Technical Reports Server (NTRS)

    Chapman, C. R.; Belton, M. J. S.; Veverka, J.; Neukum, G.; Head, J.; Greeley, Ronald; Klaasen, K.; Morrison, D.

    1994-01-01

    The second spacecraft encounter with an asteroid has yielded an unprecedentedly high resolution portrait of 243 Ida. On 28 Aug. 1993, Galileo obtained an extensive data set on this small member of the Koronis family. Most of the data recorded on the tape recorder will be returned to Earth in spring 1994. A five-frame mosaic of Ida was acquired with good illumination geometry a few minutes before closest approach; it has a resolution of 31 to 38 m/pixel amd was played back during Sept. 1993. Preliminary analyses of this single view of Ida are summarized.

  18. First images of asteroid 243 Ida

    USGS Publications Warehouse

    Belton, M.J.S.; Chapman, C.R.; Veverka, J.; Klaasen, K.P.; Harch, A.; Greeley, R.; Greenberg, R.; Head, J. W., III; McEwen, A.; Morrison, D.; Thomas, P.C.; Davies, M.E.; Carr, M.H.; Neukum, G.; Fanale, F.P.; Davis, D.R.; Anger, C.; Gierasch, P.J.; Ingersoll, A.P.; Pilcher, C.B.

    1994-01-01

    The first images of the asteroid 243 Ida from Galileo show an irregular object measuring 56 kilometers by 24 kilometers by 21 kilometers. Its surface is rich in geologic features, including systems of grooves, blocks, chutes, albedo features, crater chains, and a full range of crater morphologies. The largest blocks may be distributed nonuniformly across the surface; lineaments and dark-floored craters also have preferential locations. Ida is interpreted to have a substantial regolith. The high crater density and size-frequency distribution (-3 differential power-law index) indicate a surface in equilibrium with saturated cratering. A minimum model crater age for Ida - and therefore for the Koronis family to which Ida belongs - is estimated at 1 billion years, older than expected.

  19. 48 CFR 252.243-7001 - Pricing of contract modifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Pricing of contract... of Provisions And Clauses 252.243-7001 Pricing of contract modifications. As prescribed in 243.205-70, use the following clause: Pricing of Contract Modifications (DEC 1991) When costs are a factor in...

  20. 48 CFR 252.243-7001 - Pricing of contract modifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Pricing of contract... of Provisions And Clauses 252.243-7001 Pricing of contract modifications. As prescribed in 243.205-70, use the following clause: Pricing of Contract Modifications (DEC 1991) When costs are a factor in...

  1. 48 CFR 252.243-7001 - Pricing of contract modifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Pricing of contract... of Provisions And Clauses 252.243-7001 Pricing of contract modifications. As prescribed in 243.205-70, use the following clause: Pricing of Contract Modifications (DEC 1991) When costs are a factor in...

  2. 48 CFR 252.243-7001 - Pricing of contract modifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Pricing of contract... of Provisions And Clauses 252.243-7001 Pricing of contract modifications. As prescribed in 243.205-70, use the following clause: Pricing of Contract Modifications (DEC 1991) When costs are a factor in...

  3. 48 CFR 252.243-7001 - Pricing of contract modifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Pricing of contract... of Provisions And Clauses 252.243-7001 Pricing of contract modifications. As prescribed in 243.205-70, use the following clause: Pricing of Contract Modifications (DEC 1991) When costs are a factor in...

  4. 48 CFR 1852.243-71 - Shared savings.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Shared savings. 1852.243-71 Section 1852.243-71 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION... from the implementation of cost reduction projects which are presented to the Government in the form...

  5. 48 CFR 243.204-70-2 - Price ceiling.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Price ceiling. 243.204-70..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204-70-2 Price ceiling. Unpriced change orders shall include a not-to-exceed price....

  6. 9 CFR 354.243 - Operations and procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Operations and procedures. 354.243 Section 354.243 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION VOLUNTARY...

  7. 9 CFR 354.243 - Operations and procedures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Operations and procedures. 354.243 Section 354.243 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION VOLUNTARY...

  8. 48 CFR 243.204-70-2 - Price ceiling.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Price ceiling. 243.204-70..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204-70-2 Price ceiling. Unpriced change orders shall include a not-to-exceed price....

  9. 48 CFR 243.204-70-2 - Price ceiling.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Price ceiling. 243.204-70..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204-70-2 Price ceiling. Unpriced change orders shall include a not-to-exceed price....

  10. 48 CFR 243.204-70-2 - Price ceiling.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Price ceiling. 243.204-70..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204-70-2 Price ceiling. Unpriced change orders shall include a not-to-exceed price....

  11. 48 CFR 243.204-70-2 - Price ceiling.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Price ceiling. 243.204-70..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204-70-2 Price ceiling. Unpriced change orders shall include a not-to-exceed price....

  12. 49 CFR 199.243 - Referral, evaluation, and treatment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Referral, evaluation, and treatment. 199.243... ALCOHOL TESTING Alcohol Misuse Prevention Program § 199.243 Referral, evaluation, and treatment. (a) Each... abuse professionals and counseling and treatment programs. (b) Each covered employee who engages...

  13. 14 CFR 121.243 - Engine breather lines.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Engine breather lines. 121.243 Section 121... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Special Airworthiness Requirements § 121.243 Engine breather lines. (a) Engine breather lines must be so arranged that condensed water vapor that may...

  14. 14 CFR 121.243 - Engine breather lines.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Engine breather lines. 121.243 Section 121... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Special Airworthiness Requirements § 121.243 Engine breather lines. (a) Engine breather lines must be so arranged that condensed water vapor that may...

  15. 14 CFR 121.243 - Engine breather lines.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Engine breather lines. 121.243 Section 121... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Special Airworthiness Requirements § 121.243 Engine breather lines. (a) Engine breather lines must be so arranged that condensed water vapor that may...

  16. 14 CFR 243.15 - Conflict with foreign laws.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Conflict with foreign laws. 243.15 Section 243.15 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION... collection would violate applicable foreign law, but only to the extent it is established by the carrier...

  17. 14 CFR 243.15 - Conflict with foreign laws.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Conflict with foreign laws. 243.15 Section 243.15 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION... collection would violate applicable foreign law, but only to the extent it is established by the carrier...

  18. 14 CFR 243.15 - Conflict with foreign laws.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Conflict with foreign laws. 243.15 Section 243.15 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION... collection would violate applicable foreign law, but only to the extent it is established by the carrier...

  19. 14 CFR 243.15 - Conflict with foreign laws.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Conflict with foreign laws. 243.15 Section 243.15 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION... collection would violate applicable foreign law, but only to the extent it is established by the carrier...

  20. 40 CFR 243.202-2 - Recommended procedures: Design.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Recommended procedures: Design. 243.202-2 Section 243.202-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE STORAGE AND COLLECTION OF RESIDENTIAL, COMMERCIAL, AND INSTITUTIONAL SOLID WASTE Requirements and Recommended Procedures...

  1. 40 CFR 243.202-2 - Recommended procedures: Design.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Recommended procedures: Design. 243.202-2 Section 243.202-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE STORAGE AND COLLECTION OF RESIDENTIAL, COMMERCIAL, AND INSTITUTIONAL SOLID WASTE Requirements and Recommended Procedures §...

  2. 40 CFR 243.204-2 - Recommended procedures: Operations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Recommended procedures: Operations. 243.204-2 Section 243.204-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE STORAGE AND COLLECTION OF RESIDENTIAL, COMMERCIAL, AND INSTITUTIONAL SOLID WASTE Requirements and Recommended Procedures...

  3. 40 CFR 243.200-2 - Recommended procedures: Design.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Recommended procedures: Design. 243.200-2 Section 243.200-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE STORAGE AND COLLECTION OF RESIDENTIAL, COMMERCIAL, AND INSTITUTIONAL SOLID WASTE Requirements and Recommended Procedures §...

  4. 5 CFR 531.243 - Promotion of a GM employee.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Promotion of a GM employee. 531.243... UNDER THE GENERAL SCHEDULE Determining Rate of Basic Pay Special Rules for Gm Employees § 531.243 Promotion of a GM employee. (a) Upon promotion, an employee's status as a GM employee ends, as provided...

  5. 7 CFR 4279.238-4279.243 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false 4279.238-4279.243 Section 4279.238-4279.243 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE GUARANTEED LOANMAKING Biorefinery Assistance...

  6. 7 CFR 4279.238-4279.243 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false 4279.238-4279.243 Section 4279.238-4279.243 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE GUARANTEED LOANMAKING Biorefinery Assistance...

  7. 7 CFR 4279.238-4279.243 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false 4279.238-4279.243 Section 4279.238-4279.243 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE GUARANTEED LOANMAKING Biorefinery Assistance...

  8. 19 CFR 10.243 - Articles eligible for preferential treatment.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 1 2012-04-01 2012-04-01 false Articles eligible for preferential treatment. 10.243 Section 10.243 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. Andean Trade Promotion and Drug Eradication Act Apparel...

  9. 19 CFR 10.243 - Articles eligible for preferential treatment.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 1 2013-04-01 2013-04-01 false Articles eligible for preferential treatment. 10.243 Section 10.243 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. Andean Trade Promotion and Drug Eradication Act Apparel...

  10. 40 CFR 421.242-421.243 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 30 2012-07-01 2012-07-01 false 421.242-421.243 Section 421.242-421.243 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS NONFERROUS METALS MANUFACTURING POINT SOURCE CATEGORY Secondary Nickel Subcategory §§...

  11. 12 CFR 19.243 - Removal, suspension, or debarment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... the same manner as other hearings under the Uniform Rules of Practice and Procedure (12 CFR part 19... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Removal, suspension, or debarment. 19.243 Section 19.243 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY RULES OF...

  12. 14 CFR 121.243 - Engine breather lines.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Engine breather lines. 121.243 Section 121... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Special Airworthiness Requirements § 121.243 Engine breather lines. (a) Engine breather lines must be so arranged that condensed water vapor that may...

  13. 49 CFR 199.243 - Referral, evaluation, and treatment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... for drugs, as directed by the substance abuse professional, to be performed in accordance with 49 CFR... 49 Transportation 3 2011-10-01 2011-10-01 false Referral, evaluation, and treatment. 199.243... ALCOHOL TESTING Alcohol Misuse Prevention Program § 199.243 Referral, evaluation, and treatment. (a)...

  14. 14 CFR 121.243 - Engine breather lines.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Engine breather lines. 121.243 Section 121... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Special Airworthiness Requirements § 121.243 Engine breather lines. (a) Engine breather lines must be so arranged that condensed water vapor that may...

  15. 48 CFR 243.170 - Identification of foreign military sale (FMS) requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... military sale (FMS) requirements. 243.170 Section 243.170 Federal Acquisition Regulations System DEFENSE....170 Identification of foreign military sale (FMS) requirements. Follow the procedures at PGI 243.170 for identifying contract modifications that add FMS requirements....

  16. 48 CFR 243.170 - Identification of foreign military sale (FMS) requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... military sale (FMS) requirements. 243.170 Section 243.170 Federal Acquisition Regulations System DEFENSE....170 Identification of foreign military sale (FMS) requirements. Follow the procedures at PGI 243.170 for identifying contract modifications that add FMS requirements....

  17. 48 CFR 243.170 - Identification of foreign military sale (FMS) requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... military sale (FMS) requirements. 243.170 Section 243.170 Federal Acquisition Regulations System DEFENSE....170 Identification of foreign military sale (FMS) requirements. Follow the procedures at PGI 243.170 for identifying contract modifications that add FMS requirements....

  18. MAGAZINE 242, REAR VIEW WITH MAGAZINE 243 IN BACKGROUND ON ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    MAGAZINE 242, REAR VIEW WITH MAGAZINE 243 IN BACKGROUND ON RIGHT. - Naval Magazine Lualualei, West Loch Branch, Magazine Type 2, Fourth Place, Seventh & Eighth Streets, Pearl City, Honolulu County, HI

  19. MAGAZINE 243, FRONT ELEVATION WITH POLE. MAGAZINE 242 IN BACKGROUND. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    MAGAZINE 243, FRONT ELEVATION WITH POLE. MAGAZINE 242 IN BACKGROUND. - Naval Magazine Lualualei, West Loch Branch, Magazine Type 2, Fourth Place, Seventh & Eighth Streets, Pearl City, Honolulu County, HI

  20. 5. NORTH AND WEST SIDES OF BUILDING 243. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. NORTH AND WEST SIDES OF BUILDING 243. VIEW TO SOUTHEAST. - Rocky Mountain Arsenal, Chlorine Production Cell Building, 405 feet South of December Seventh Avenue; 330 feet West of D Street, Commerce City, Adams County, CO

  1. 6. WEST AND SOUTH SIDES OF BUILDING 243. VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. WEST AND SOUTH SIDES OF BUILDING 243. VIEW TO NORTHEAST. - Rocky Mountain Arsenal, Chlorine Production Cell Building, 405 feet South of December Seventh Avenue; 330 feet West of D Street, Commerce City, Adams County, CO

  2. 40 CFR 243.202-3 - Recommended procedures: Operations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... SOLID WASTE Requirements and Recommended Procedures § 243.202-3 Recommended procedures: Operations. (a... once a week. (b) Solid waste should not be allowed to remain in collection vehicles over 24 hours...

  3. 40 CFR 243.202-3 - Recommended procedures: Operations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... SOLID WASTE Requirements and Recommended Procedures § 243.202-3 Recommended procedures: Operations. (a... once a week. (b) Solid waste should not be allowed to remain in collection vehicles over 24 hours...

  4. 9 CFR 354.243 - Operations and procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Sanitary Conditions and Precautions Against Contamination of Products § 354.243 Operations and procedures... product against contamination by any foreign substance (including, but not being limited to, dust,...

  5. 9 CFR 354.243 - Operations and procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Sanitary Conditions and Precautions Against Contamination of Products § 354.243 Operations and procedures... product against contamination by any foreign substance (including, but not being limited to, dust,...

  6. 48 CFR 243.204-70 - Definitization of change orders.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204-70 Definitization of change orders. ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Definitization of...

  7. 48 CFR 243.204-70 - Definitization of change orders.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204-70 Definitization of change orders. ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Definitization of...

  8. 48 CFR 243.204-70 - Definitization of change orders.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204-70 Definitization of change orders. ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Definitization of...

  9. 48 CFR 243.204-70 - Definitization of change orders.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204-70 Definitization of change orders. ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Definitization of...

  10. 9 CFR 354.243 - Operations and procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Sanitary Conditions and Precautions Against Contamination of Products § 354.243 Operations and procedures... product against contamination by any foreign substance (including, but not being limited to, dust,...

  11. Atomic Mass and Nuclear Binding Energy for Es-243 (Einsteinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Es-243 (Einsteinium, atomic number Z = 99, mass number A = 243).

  12. Atomic Mass and Nuclear Binding Energy for At-243 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-243 (Astatine, atomic number Z = 85, mass number A = 243).

  13. Atomic Mass and Nuclear Binding Energy for Ac-243 (Actinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Ac-243 (Actinium, atomic number Z = 89, mass number A = 243).

  14. SARSAT 121.5/243 MHz technical evaluation

    NASA Technical Reports Server (NTRS)

    Hayes, E. J.; Kissel, F. J.; Bossuat, F.

    1984-01-01

    The NOAA 8 SARSAT system performance was tested at 121.5/243 MHz to measure detection probability, detection threshold, location accuracy, ambiguity resolution, and multiple access capacity. Detection probability exceeds 0.95 for a single satellite pass. Detection threshold margin varies from 2 dB (243 MHz, incoherent) to 20 dB (121.5, coherent). Position location error is 20 km 68% of the time. Ambiguity is resolved 75% of the time. The system can locate 10 separate test signals.

  15. 40 CFR 60.243 - Monitoring of operations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Fertilizer Industry: Granular Triple Superphosphate Storage Facilities § 60.243 Monitoring of operations. (a) The owner or operator of any granular triple superphosphate storage facility subject to the provisions of this subpart shall maintain an accurate account of triple superphosphate in storage to permit...

  16. 40 CFR 60.243 - Monitoring of operations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Fertilizer Industry: Granular Triple Superphosphate Storage Facilities § 60.243 Monitoring of operations. (a) The owner or operator of any granular triple superphosphate storage facility subject to the provisions of this subpart shall maintain an accurate account of triple superphosphate in storage to permit...

  17. 40 CFR 60.243 - Monitoring of operations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Fertilizer Industry: Granular Triple Superphosphate Storage Facilities § 60.243 Monitoring of operations. (a) The owner or operator of any granular triple superphosphate storage facility subject to the provisions of this subpart shall maintain an accurate account of triple superphosphate in storage to permit...

  18. 40 CFR 60.243 - Monitoring of operations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Fertilizer Industry: Granular Triple Superphosphate Storage Facilities § 60.243 Monitoring of operations. (a) The owner or operator of any granular triple superphosphate storage facility subject to the provisions of this subpart shall maintain an accurate account of triple superphosphate in storage to permit...

  19. 40 CFR 60.243 - Monitoring of operations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Fertilizer Industry: Granular Triple Superphosphate Storage Facilities § 60.243 Monitoring of operations. (a) The owner or operator of any granular triple superphosphate storage facility subject to the provisions of this subpart shall maintain an accurate account of triple superphosphate in storage to permit...

  20. 43 CFR 24.3 - General jurisdictional principles.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... enactment of Federal fish and wildlife conservation statutes has generally been associated with the... FISH AND WILDLIFE POLICY: STATE-FEDERAL RELATIONSHIPS § 24.3 General jurisdictional principles. (a) In general the States possess broad trustee and police powers over fish and wildlife within their...

  1. 43 CFR 24.3 - General jurisdictional principles.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... enactment of Federal fish and wildlife conservation statutes has generally been associated with the... FISH AND WILDLIFE POLICY: STATE-FEDERAL RELATIONSHIPS § 24.3 General jurisdictional principles. (a) In general the States possess broad trustee and police powers over fish and wildlife within their...

  2. 43 CFR 24.3 - General jurisdictional principles.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... enactment of Federal fish and wildlife conservation statutes has generally been associated with the... FISH AND WILDLIFE POLICY: STATE-FEDERAL RELATIONSHIPS § 24.3 General jurisdictional principles. (a) In general the States possess broad trustee and police powers over fish and wildlife within their...

  3. 43 CFR 24.3 - General jurisdictional principles.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... enactment of Federal fish and wildlife conservation statutes has generally been associated with the... FISH AND WILDLIFE POLICY: STATE-FEDERAL RELATIONSHIPS § 24.3 General jurisdictional principles. (a) In general the States possess broad trustee and police powers over fish and wildlife within their...

  4. 49 CFR 372.243 - Controlling distances and population data.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 5 2013-10-01 2013-10-01 false Controlling distances and population data. 372.243... population data. In the application of § 372.241: (a) Air-line distances or mileages about corporate limits of municipalities shall be used. (b) The population of any municipality shall be deemed to be...

  5. 49 CFR 372.243 - Controlling distances and population data.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 5 2014-10-01 2014-10-01 false Controlling distances and population data. 372.243... population data. In the application of § 372.241: (a) Air-line distances or mileages about corporate limits of municipalities shall be used. (b) The population of any municipality shall be deemed to be...

  6. 49 CFR 372.243 - Controlling distances and population data.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 5 2011-10-01 2011-10-01 false Controlling distances and population data. 372.243... population data. In the application of § 372.241: (a) Air-line distances or mileages about corporate limits of municipalities shall be used. (b) The population of any municipality shall be deemed to be...

  7. 49 CFR 372.243 - Controlling distances and population data.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Controlling distances and population data. 372.243... population data. In the application of § 372.241: (a) Air-line distances or mileages about corporate limits of municipalities shall be used. (b) The population of any municipality shall be deemed to be...

  8. 49 CFR 372.243 - Controlling distances and population data.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 5 2012-10-01 2012-10-01 false Controlling distances and population data. 372.243... population data. In the application of § 372.241: (a) Air-line distances or mileages about corporate limits of municipalities shall be used. (b) The population of any municipality shall be deemed to be...

  9. 48 CFR 52.243-1 - Changes-Fixed-Price.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false Changes-Fixed-Price. 52....243-1 Changes—Fixed-Price. As prescribed in 43.205(e), insert the following clause: Changes—Fixed-Price (AUG 1987) (a) The Contracting Officer may at any time, by written order, and without notice...

  10. 48 CFR 52.243-1 - Changes-Fixed-Price.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 2 2014-10-01 2014-10-01 false Changes-Fixed-Price. 52....243-1 Changes—Fixed-Price. As prescribed in 43.205(e), insert the following clause: Changes—Fixed-Price (AUG 1987) (a) The Contracting Officer may at any time, by written order, and without notice...

  11. 48 CFR 52.243-1 - Changes-Fixed-Price.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 2 2012-10-01 2012-10-01 false Changes-Fixed-Price. 52....243-1 Changes—Fixed-Price. As prescribed in 43.205(e), insert the following clause: Changes—Fixed-Price (AUG 1987) (a) The Contracting Officer may at any time, by written order, and without notice...

  12. 48 CFR 52.243-1 - Changes-Fixed-Price.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false Changes-Fixed-Price. 52....243-1 Changes—Fixed-Price. As prescribed in 43.205(e), insert the following clause: Changes—Fixed-Price (AUG 1987) (a) The Contracting Officer may at any time, by written order, and without notice...

  13. 40 CFR 180.243 - Propazine; tolerances for residues.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Propazine; tolerances for residues...) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.243 Propazine; tolerances for residues. Tolerances are established for negligible residues (N)...

  14. 27 CFR 46.243 - Articles at multiple locations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2014-04-01 2014-04-01 false Articles at multiple... Cigarette Tubes Held for Sale on April 1, 2009 Records § 46.243 Articles at multiple locations. The dealer must maintain a list of all places where the dealer holds articles subject to the floor stocks...

  15. 27 CFR 46.243 - Articles at multiple locations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2012-04-01 2011-04-01 true Articles at multiple... Cigarette Tubes Held for Sale on April 1, 2009 Records § 46.243 Articles at multiple locations. The dealer must maintain a list of all places where the dealer holds articles subject to the floor stocks...

  16. 27 CFR 46.243 - Articles at multiple locations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2013-04-01 2013-04-01 false Articles at multiple... Cigarette Tubes Held for Sale on April 1, 2009 Records § 46.243 Articles at multiple locations. The dealer must maintain a list of all places where the dealer holds articles subject to the floor stocks...

  17. 48 CFR 1852.243-70 - Engineering change proposals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Engineering change... and Clauses 1852.243-70 Engineering change proposals. As prescribed in 1843.205-70(a)(1), insert the following clause, modified to suit contract type: Engineering Change Proposals (FEB 1998) (a)...

  18. 243. Photocopy of photograph from Artwork of Savannah, Ga. (Chicago: ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    243. Photocopy of photograph from Artwork of Savannah, Ga. (Chicago: W.H. Parish Publishing Co., 1893) Photographer unknown, 1893 'RESIDENCE OF J.A.G. CARSON' - Savannah Victorian Historic District, Bounded by Gwinnett, East Broad, West Broad Street & Anderson Lane, Savannah, Chatham County, GA

  19. 48 CFR 3452.243-70 - Key personnel.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 7 2012-10-01 2012-10-01 false Key personnel. 3452.243-70... Key personnel. As prescribed in 3443.107, insert a clause substantially the same as the following in... contracting officer to be notified that a change of designated key personnel is to take place by...

  20. 48 CFR 3452.243-70 - Key personnel.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Key personnel. 3452.243-70... Key personnel. As prescribed in 3443.107, insert a clause substantially the same as the following in... contracting officer to be notified that a change of designated key personnel is to take place by...

  1. 48 CFR 3452.243-70 - Key personnel.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 7 2014-10-01 2014-10-01 false Key personnel. 3452.243-70... Key personnel. As prescribed in 3443.107, insert a clause substantially the same as the following in... contracting officer to be notified that a change of designated key personnel is to take place by...

  2. 48 CFR 3452.243-70 - Key personnel.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 7 2011-10-01 2011-10-01 false Key personnel. 3452.243-70... Key personnel. As prescribed in 3443.107, insert a clause substantially the same as the following in... contracting officer to be notified that a change of designated key personnel is to take place by...

  3. 48 CFR 3452.243-70 - Key personnel.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Key personnel. 3452.243-70... Key personnel. As prescribed in 3443.106(b), insert the following clause in all solicitations and resultant cost-reimbursement contracts: Key Personnel (AUG 1987) The personnel designated as key...

  4. 40 CFR 243.204-2 - Recommended procedures: Operations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... SOLID WASTE Requirements and Recommended Procedures § 243.204-2 Recommended procedures: Operations. (a...) Solid waste collection systems should be operated in a manner designed to minimize fuel consumption... is great, transfer stations should be used when cost effective. (5) Residential solid...

  5. 40 CFR 243.200-2 - Recommended procedures: Design.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... WASTE Requirements and Recommended Procedures § 243.200-2 Recommended procedures: Design. (a) Reusable waste containers should be constructed of corrosion resistant metal or other material which will not... containers and which is maintained in a clean, spillage-free condition. (1) Reusable waste containers...

  6. 40 CFR 243.204-2 - Recommended procedures: Operations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... SOLID WASTE Requirements and Recommended Procedures § 243.204-2 Recommended procedures: Operations. (a...) Solid waste collection systems should be operated in a manner designed to minimize fuel consumption... is great, transfer stations should be used when cost effective. (5) Residential solid...

  7. 40 CFR 243.204-2 - Recommended procedures: Operations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... WASTE Requirements and Recommended Procedures § 243.204-2 Recommended procedures: Operations. (a...) Solid waste collection systems should be operated in a manner designed to minimize fuel consumption... is great, transfer stations should be used when cost effective. (5) Residential solid...

  8. 40 CFR 243.204-2 - Recommended procedures: Operations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... SOLID WASTE Requirements and Recommended Procedures § 243.204-2 Recommended procedures: Operations. (a...) Solid waste collection systems should be operated in a manner designed to minimize fuel consumption... is great, transfer stations should be used when cost effective. (5) Residential solid...

  9. 40 CFR 243.200-2 - Recommended procedures: Design.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... WASTE Requirements and Recommended Procedures § 243.200-2 Recommended procedures: Design. (a) Reusable waste containers should be constructed of corrosion resistant metal or other material which will not... containers and which is maintained in a clean, spillage-free condition. (1) Reusable waste containers...

  10. 40 CFR 243.200-2 - Recommended procedures: Design.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... WASTE Requirements and Recommended Procedures § 243.200-2 Recommended procedures: Design. (a) Reusable waste containers should be constructed of corrosion resistant metal or other material which will not... containers and which is maintained in a clean, spillage-free condition. (1) Reusable waste containers...

  11. 48 CFR 243.205-72 - Unpriced change orders.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.205-72 Unpriced change orders. See the clause prescriptions at 217.7406 for all unpriced change orders with an... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Unpriced change...

  12. 48 CFR 243.205-72 - Unpriced change orders.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.205-72 Unpriced change orders. See the clause prescriptions at 217.7406 for all unpriced change orders with an... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Unpriced change...

  13. 48 CFR 243.205-72 - Unpriced change orders.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.205-72 Unpriced change orders. See the clause prescriptions at 217.7406 for all unpriced change orders with an... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Unpriced change...

  14. 48 CFR 243.205-72 - Unpriced change orders.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.205-72 Unpriced change orders. See the clause prescriptions at 217.7406 for all unpriced change orders with an... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Unpriced change...

  15. 48 CFR 52.243-6 - Change Order Accounting.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false Change Order Accounting....243-6 Change Order Accounting. As prescribed in 43.205(f), the contracting officer may insert a clause, substantially the same as follows: Change Order Accounting (APR 1984) The Contracting Officer may require...

  16. 48 CFR 52.243-6 - Change Order Accounting.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false Change Order Accounting....243-6 Change Order Accounting. As prescribed in 43.205(f), the contracting officer may insert a clause, substantially the same as follows: Change Order Accounting (APR 1984) The Contracting Officer may require...

  17. 48 CFR 52.243-6 - Change Order Accounting.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 2 2012-10-01 2012-10-01 false Change Order Accounting....243-6 Change Order Accounting. As prescribed in 43.205(f), the contracting officer may insert a clause, substantially the same as follows: Change Order Accounting (APR 1984) The Contracting Officer may require...

  18. 48 CFR 52.243-6 - Change Order Accounting.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 2 2014-10-01 2014-10-01 false Change Order Accounting....243-6 Change Order Accounting. As prescribed in 43.205(f), the contracting officer may insert a clause, substantially the same as follows: Change Order Accounting (APR 1984) The Contracting Officer may require...

  19. 48 CFR 52.243-6 - Change Order Accounting.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Change Order Accounting....243-6 Change Order Accounting. As prescribed in 43.205(f), the contracting officer may insert a clause, substantially the same as follows: Change Order Accounting (APR 1984) The Contracting Officer may require...

  20. 40 CFR 243.200-2 - Recommended procedures: Design.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... diameter at the top of the container to facilitate discharge of the solid waste by gravity. Containers....200-2 Section 243.200-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE STORAGE AND COLLECTION OF RESIDENTIAL, COMMERCIAL, AND INSTITUTIONAL...

  1. 49 CFR 199.243 - Referral, evaluation, and treatment.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... ALCOHOL TESTING Alcohol Misuse Prevention Program § 199.243 Referral, evaluation, and treatment. (a) Each... contract to provide treatment for alcohol problems on behalf of the operator; (3) The sole source of... for drugs, as directed by the substance abuse professional, to be performed in accordance with 49...

  2. 49 CFR 199.243 - Referral, evaluation, and treatment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ALCOHOL TESTING Alcohol Misuse Prevention Program § 199.243 Referral, evaluation, and treatment. (a) Each... contract to provide treatment for alcohol problems on behalf of the operator; (3) The sole source of... for drugs, as directed by the substance abuse professional, to be performed in accordance with 49...

  3. 49 CFR 199.243 - Referral, evaluation, and treatment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... ALCOHOL TESTING Alcohol Misuse Prevention Program § 199.243 Referral, evaluation, and treatment. (a) Each... contract to provide treatment for alcohol problems on behalf of the operator; (3) The sole source of... for drugs, as directed by the substance abuse professional, to be performed in accordance with 49...

  4. 27 CFR 46.243 - Articles at multiple locations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2011-04-01 2011-04-01 false Articles at multiple... Cigarette Tubes Held for Sale on April 1, 2009 Records § 46.243 Articles at multiple locations. The dealer must maintain a list of all places where the dealer holds articles subject to the floor stocks...

  5. 27 CFR 46.243 - Articles at multiple locations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Articles at multiple... Cigarette Tubes Held for Sale on April 1, 2009 Records § 46.243 Articles at multiple locations. The dealer must maintain a list of all places where the dealer holds articles subject to the floor stocks...

  6. 14 CFR 243.11 - Transmission of information after an aviation disaster.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... aviation disaster. 243.11 Section 243.11 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS PASSENGER MANIFEST INFORMATION § 243.11 Transmission of information after an aviation disaster. (a) Each covered airline shall inform the...

  7. 14 CFR 243.11 - Transmission of information after an aviation disaster.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... aviation disaster. 243.11 Section 243.11 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS PASSENGER MANIFEST INFORMATION § 243.11 Transmission of information after an aviation disaster. (a) Each covered airline shall inform the...

  8. 14 CFR 243.11 - Transmission of information after an aviation disaster.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... aviation disaster. 243.11 Section 243.11 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS PASSENGER MANIFEST INFORMATION § 243.11 Transmission of information after an aviation disaster. (a) Each covered airline shall inform the...

  9. 14 CFR 243.11 - Transmission of information after an aviation disaster.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... aviation disaster. 243.11 Section 243.11 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS PASSENGER MANIFEST INFORMATION § 243.11 Transmission of information after an aviation disaster. (a) Each covered airline shall inform the...

  10. 14 CFR 243.11 - Transmission of information after an aviation disaster.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... aviation disaster. 243.11 Section 243.11 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS PASSENGER MANIFEST INFORMATION § 243.11 Transmission of information after an aviation disaster. (a) Each covered airline shall inform the...

  11. 40 CFR 1037.243 - Demonstrating compliance with evaporative emission standards.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... evaporative emission standards. 1037.243 Section 1037.243 Protection of Environment ENVIRONMENTAL PROTECTION... Certifying Vehicle families § 1037.243 Demonstrating compliance with evaporative emission standards. (a) For purposes of certification, your vehicle family is considered in compliance with the evaporative...

  12. 47 CFR 15.243 - Operation in the band 890-940 MHz.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Operation in the band 890-940 MHz. 15.243 Section 15.243 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES Intentional Radiators Radiated Emission Limits, Additional Provisions § 15.243 Operation in the band...

  13. 47 CFR 15.243 - Operation in the band 890-940 MHz.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Operation in the band 890-940 MHz. 15.243 Section 15.243 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES Intentional Radiators Radiated Emission Limits, Additional Provisions § 15.243 Operation in the band...

  14. 47 CFR 15.243 - Operation in the band 890-940 MHz.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Operation in the band 890-940 MHz. 15.243 Section 15.243 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES Intentional Radiators Radiated Emission Limits, Additional Provisions § 15.243 Operation in the band...

  15. 47 CFR 15.243 - Operation in the band 890-940 MHz.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Operation in the band 890-940 MHz. 15.243 Section 15.243 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES Intentional Radiators Radiated Emission Limits, Additional Provisions § 15.243 Operation in the band...

  16. 47 CFR 15.243 - Operation in the band 890-940 MHz.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false Operation in the band 890-940 MHz. 15.243 Section 15.243 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES Intentional Radiators Radiated Emission Limits, Additional Provisions § 15.243 Operation in the band...

  17. 25 CFR 243.10 - How does the Paperwork Reduction Act affect this rule?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How does the Paperwork Reduction Act affect this rule? 243.10 Section 243.10 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.10 How does the Paperwork Reduction Act affect this rule? The actions in this...

  18. 25 CFR 243.10 - How does the Paperwork Reduction Act affect this rule?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false How does the Paperwork Reduction Act affect this rule? 243.10 Section 243.10 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.10 How does the Paperwork Reduction Act affect this rule? The actions in this...

  19. 25 CFR 243.4 - Who can own or possess Alaskan reindeer?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Who can own or possess Alaskan reindeer? 243.4 Section 243.4 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.4 Who can own or possess Alaskan reindeer? (a) Only Alaska Natives, organizations of...

  20. 25 CFR 243.10 - How does the Paperwork Reduction Act affect this rule?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true How does the Paperwork Reduction Act affect this rule? 243.10 Section 243.10 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.10 How does the Paperwork Reduction Act affect this rule? The actions in this...

  1. 25 CFR 243.4 - Who can own or possess Alaskan reindeer?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Who can own or possess Alaskan reindeer? 243.4 Section 243.4 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.4 Who can own or possess Alaskan reindeer? (a) Only Alaska Natives, organizations of...

  2. 25 CFR 243.4 - Who can own or possess Alaskan reindeer?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true Who can own or possess Alaskan reindeer? 243.4 Section 243.4 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.4 Who can own or possess Alaskan reindeer? (a) Only Alaska Natives, organizations of...

  3. 25 CFR 243.10 - How does the Paperwork Reduction Act affect this rule?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false How does the Paperwork Reduction Act affect this rule? 243.10 Section 243.10 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.10 How does the Paperwork Reduction Act affect this rule? The actions in this...

  4. 25 CFR 243.4 - Who can own or possess Alaskan reindeer?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Who can own or possess Alaskan reindeer? 243.4 Section 243.4 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.4 Who can own or possess Alaskan reindeer? (a) Only Alaska Natives, organizations of...

  5. 25 CFR 243.4 - Who can own or possess Alaskan reindeer?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Who can own or possess Alaskan reindeer? 243.4 Section 243.4 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.4 Who can own or possess Alaskan reindeer? (a) Only Alaska Natives, organizations of...

  6. 25 CFR 243.10 - How does the Paperwork Reduction Act affect this rule?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false How does the Paperwork Reduction Act affect this rule? 243.10 Section 243.10 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.10 How does the Paperwork Reduction Act affect this rule? The actions in this...

  7. 14 CFR 243.9 - Procedures for collecting and maintaining the information.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Procedures for collecting and maintaining the information. 243.9 Section 243.9 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS PASSENGER MANIFEST INFORMATION § 243.9 Procedures...

  8. 20 CFR 243.3 - Payments pursuant to court decree or court-approved property settlement.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true Payments pursuant to court decree or court-approved property settlement. 243.3 Section 243.3 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT TRANSFER, ASSIGNMENT, OR WAIVER OF PAYMENTS § 243.3 Payments...

  9. 30 CFR 243.201 - How will MMS determine if I am financially solvent?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... making payments found in 30 CFR 218.51. You are not required to use Electronic Funds Transfer (EFT) for... solvent? 243.201 Section 243.201 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR... Solvency Requirements § 243.201 How will MMS determine if I am financially solvent? (a) The MMS...

  10. Fission probabilities of 242Am,243Cm , and 244Cm induced by transfer reactions

    NASA Astrophysics Data System (ADS)

    Kessedjian, G.; Jurado, B.; Barreau, G.; Marini, P.; Mathieu, L.; Tsekhanovich, I.; Aiche, M.; Boutoux, G.; Czajkowski, S.; Ducasse, Q.

    2015-04-01

    We have measured the fission probabilities of 242Am,243Cm , and 244Cm induced by the transfer reactions 243Am(3He,4He) ,243Am(3He,t ) , and 243Am(3He,d ) , respectively. The details of the experimental procedure and a rigorous uncertainty analysis, including a correlation matrix, are presented. For 243Cm our data show clear structures well below the fission threshold. To our knowledge, it is the first time that these structures have been observed for this nucleus. We have compared the measured fission probabilities to calculations based on the statistical model to obtain information on the fission barriers of the produced fissioning nuclei.

  11. Fission dynamics study in 243Am and 254Fm

    NASA Astrophysics Data System (ADS)

    Banerjee, K.; Ghosh, T. K.; Roy, P.; Bhattacharya, S.; Chaudhuri, A.; Bhattacharya, C.; Pandey, R.; Kundu, S.; Mukherjee, G.; Rana, T. K.; Meena, J. K.; Mohanto, G.; Dubey, R.; Saneesh, N.; Sugathan, P.; Guin, R.; Das, S.; Bhattacharya, P.

    2016-06-01

    Fission fragment mass distributions in the reactions 11B + 232Th and 11B + 243Am were measured in an energy range around the barrier. No sudden change in the width of the mass distribution as a function of center-of-mass energy was observed at near-barrier energies, indicating no quasifission transition in the near-barrier energies. Interestingly, the previous measurements of fission fragment angular anisotropies for the same systems showed significant departure from the statistical saddle-point model predictions at near-barrier energies, indicating the presence of nonequilibrium fission processes.

  12. 25 CFR 243.7 - How can a non-Native acquire live reindeer?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false How can a non-Native acquire live reindeer? 243.7 Section 243.7 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.7 How can a non-Native acquire live reindeer? If you are a non-Native who wants to...

  13. 25 CFR 243.7 - How can a non-Native acquire live reindeer?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false How can a non-Native acquire live reindeer? 243.7 Section 243.7 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.7 How can a non-Native acquire live reindeer? If you are a non-Native who wants to...

  14. 25 CFR 243.7 - How can a non-Native acquire live reindeer?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How can a non-Native acquire live reindeer? 243.7 Section 243.7 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.7 How can a non-Native acquire live reindeer? If you are a non-Native who wants to...

  15. 25 CFR 243.7 - How can a non-Native acquire live reindeer?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true How can a non-Native acquire live reindeer? 243.7 Section 243.7 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.7 How can a non-Native acquire live reindeer? If you are a non-Native who wants to...

  16. 25 CFR 243.7 - How can a non-Native acquire live reindeer?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false How can a non-Native acquire live reindeer? 243.7 Section 243.7 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.7 How can a non-Native acquire live reindeer? If you are a non-Native who wants to...

  17. 21 CFR 1.243 - Is food registration information available to the public?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Is food registration information available to the public? 1.243 Section 1.243 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL GENERAL ENFORCEMENT REGULATIONS Registration of Food Facilities Additional Provisions §...

  18. 25 CFR 243.8 - What penalties apply to violations of this part?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Section 243.8 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN... live Alaskan reindeer who violates the provisions of this part, you are subject to the penalties in... reindeer without a permit issued under § 243.7; or (2) Do not abide by the terms of a permit issued...

  19. 25 CFR 243.13 - Who may appeal an action under this part?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... decision under this part has the right of appeal as provided in 25 CFR part 2 and 43 CFR part 4, subpart D. ... 25 Indians 1 2014-04-01 2014-04-01 false Who may appeal an action under this part? 243.13 Section 243.13 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER...

  20. 25 CFR 243.8 - What penalties apply to violations of this part?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Section 243.8 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN... live Alaskan reindeer who violates the provisions of this part, you are subject to the penalties in... reindeer without a permit issued under § 243.7; or (2) Do not abide by the terms of a permit issued...

  1. 25 CFR 243.8 - What penalties apply to violations of this part?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Section 243.8 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN... live Alaskan reindeer who violates the provisions of this part, you are subject to the penalties in... reindeer without a permit issued under § 243.7; or (2) Do not abide by the terms of a permit issued...

  2. 25 CFR 243.8 - What penalties apply to violations of this part?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Section 243.8 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN... live Alaskan reindeer who violates the provisions of this part, you are subject to the penalties in... reindeer without a permit issued under § 243.7; or (2) Do not abide by the terms of a permit issued...

  3. 25 CFR 243.8 - What penalties apply to violations of this part?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Section 243.8 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN... live Alaskan reindeer who violates the provisions of this part, you are subject to the penalties in... reindeer without a permit issued under § 243.7; or (2) Do not abide by the terms of a permit issued...

  4. 25 CFR 243.13 - Who may appeal an action under this part?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... decision under this part has the right of appeal as provided in 25 CFR part 2 and 43 CFR part 4, subpart D. ... 25 Indians 1 2012-04-01 2011-04-01 true Who may appeal an action under this part? 243.13 Section 243.13 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER...

  5. 25 CFR 243.13 - Who may appeal an action under this part?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... decision under this part has the right of appeal as provided in 25 CFR part 2 and 43 CFR part 4, subpart D. ... 25 Indians 1 2013-04-01 2013-04-01 false Who may appeal an action under this part? 243.13 Section 243.13 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER...

  6. 25 CFR 243.13 - Who may appeal an action under this part?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... decision under this part has the right of appeal as provided in 25 CFR part 2 and 43 CFR part 4, subpart D. ... 25 Indians 1 2010-04-01 2010-04-01 false Who may appeal an action under this part? 243.13 Section 243.13 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER...

  7. 25 CFR 243.13 - Who may appeal an action under this part?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... decision under this part has the right of appeal as provided in 25 CFR part 2 and 43 CFR part 4, subpart D. ... 25 Indians 1 2011-04-01 2011-04-01 false Who may appeal an action under this part? 243.13 Section 243.13 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER...

  8. 30 CFR 243.8 - When will MMS suspend my obligation to comply with an order?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... with an order? 243.8 Section 243.8 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT SUSPENSIONS PENDING APPEAL AND BONDING-MINERALS REVENUE MANAGEMENT... with the Bureau of Land Management for onshore leases, and MMS for OCS leases, as collateral for...

  9. 48 CFR 52.243-3 - Changes-Time-and-Materials or Labor-Hours.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false Changes-Time-and-Materials or Labor-Hours. 52.243-3 Section 52.243-3 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses...

  10. 42 CFR 456.243 - Content of medical care evaluation studies.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 4 2012-10-01 2012-10-01 false Content of medical care evaluation studies. 456.243... Ur Plan: Medical Care Evaluation Studies § 456.243 Content of medical care evaluation studies. Each medical care evaluation study must— (a) Identify and analyze medical or administrative factors related...

  11. 42 CFR 456.243 - Content of medical care evaluation studies.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 4 2013-10-01 2013-10-01 false Content of medical care evaluation studies. 456.243... Ur Plan: Medical Care Evaluation Studies § 456.243 Content of medical care evaluation studies. Each medical care evaluation study must— (a) Identify and analyze medical or administrative factors related...

  12. 42 CFR 456.243 - Content of medical care evaluation studies.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 4 2011-10-01 2011-10-01 false Content of medical care evaluation studies. 456.243... Ur Plan: Medical Care Evaluation Studies § 456.243 Content of medical care evaluation studies. Each medical care evaluation study must— (a) Identify and analyze medical or administrative factors related...

  13. 42 CFR 456.243 - Content of medical care evaluation studies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Content of medical care evaluation studies. 456.243... Ur Plan: Medical Care Evaluation Studies § 456.243 Content of medical care evaluation studies. Each medical care evaluation study must— (a) Identify and analyze medical or administrative factors related...

  14. 42 CFR 456.243 - Content of medical care evaluation studies.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 4 2014-10-01 2014-10-01 false Content of medical care evaluation studies. 456.243... Ur Plan: Medical Care Evaluation Studies § 456.243 Content of medical care evaluation studies. Each medical care evaluation study must— (a) Identify and analyze medical or administrative factors related...

  15. 30 CFR 243.202 - When will MMS monitor my financial solvency?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false When will MMS monitor my financial solvency? 243.202 Section 243.202 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT SUSPENSIONS PENDING APPEAL AND BONDING-MINERALS REVENUE MANAGEMENT...

  16. 30 CFR 243.200 - How do I demonstrate financial solvency?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do I demonstrate financial solvency? 243.200 Section 243.200 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT SUSPENSIONS PENDING APPEAL AND BONDING-MINERALS REVENUE MANAGEMENT Financial...

  17. 30 CFR 550.243 - What general information must accompany the DPP or DOCD?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false What general information must accompany the DPP or DOCD? 550.243 Section 550.243 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Plans and Information Contents of Development and...

  18. 48 CFR 1652.243-70 - Changes-Negotiated benefits contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Changes-Negotiated benefits contracts. 1652.243-70 Section 1652.243-70 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION CLAUSES AND FORMS CONTRACT CLAUSES Texts of FEHBP Clauses...

  19. 48 CFR 243.170 - Identification of foreign military sale (FMS) requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Identification of foreign military sale (FMS) requirements. 243.170 Section 243.170 Federal Acquisition Regulations System DEFENSE....170 Identification of foreign military sale (FMS) requirements. Follow the procedures at PGI...

  20. 48 CFR 243.170 - Identification of foreign military sale (FMS) requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Identification of foreign military sale (FMS) requirements. 243.170 Section 243.170 Federal Acquisition Regulations System DEFENSE....170 Identification of foreign military sale (FMS) requirements. Follow the procedures at PGI...

  1. 20 CFR 243.5 - Assignment of a portion of an annuity paid under the social security overall minimum provision.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... under the social security overall minimum provision. 243.5 Section 243.5 Employees' Benefits RAILROAD... § 243.5 Assignment of a portion of an annuity paid under the social security overall minimum provision. Section 3(f)(3) of the Railroad Retirement Act, the social security overall minimum provision,...

  2. 20 CFR 243.5 - Assignment of a portion of an annuity paid under the social security overall minimum provision.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... under the social security overall minimum provision. 243.5 Section 243.5 Employees' Benefits RAILROAD... § 243.5 Assignment of a portion of an annuity paid under the social security overall minimum provision. Section 3(f)(3) of the Railroad Retirement Act, the social security overall minimum provision,...

  3. 20 CFR 243.5 - Assignment of a portion of an annuity paid under the social security overall minimum provision.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... under the social security overall minimum provision. 243.5 Section 243.5 Employees' Benefits RAILROAD... § 243.5 Assignment of a portion of an annuity paid under the social security overall minimum provision. Section 3(f)(3) of the Railroad Retirement Act, the social security overall minimum provision,...

  4. 20 CFR 243.5 - Assignment of a portion of an annuity paid under the social security overall minimum provision.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... under the social security overall minimum provision. 243.5 Section 243.5 Employees' Benefits RAILROAD... § 243.5 Assignment of a portion of an annuity paid under the social security overall minimum provision. Section 3(f)(3) of the Railroad Retirement Act, the social security overall minimum provision,...

  5. 20 CFR 243.5 - Assignment of a portion of an annuity paid under the social security overall minimum provision.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... under the social security overall minimum provision. 243.5 Section 243.5 Employees' Benefits RAILROAD... § 243.5 Assignment of a portion of an annuity paid under the social security overall minimum provision. Section 3(f)(3) of the Railroad Retirement Act, the social security overall minimum provision,...

  6. Asteroid 243 IDA and its satellite. [Abstract only

    NASA Technical Reports Server (NTRS)

    Chapman, C. R.; Klaasen, K.; Belton, M. J. S.; Veverka, J.

    1994-01-01

    A high-resolution mosaic of Ida shows a highly irregular body (roughly 56 km long), heavily covered with craters, with many interesting geological features, including grooves, blocks, chutes, dark-floored craters, and crater chains. A satellite of Ida, with a preliminary designation of 1993 (243) 1, was discovered in orbit around Ida. It is approximately 1.5 km in diameter, has an albedo and spectral reflectance not grossly different from Ida, and orbits Ida in a prograde direction with a period of roughly 20 hr. No other comparable-sized satellites have been found near Ida. New pictures of the opposite side of Ida reveal an irregular, dog-bone shape, with a prominent gouge that seems to separate Ida into two chief components. A V-shaped valley, well shown in the highest-resolution view of Ida returned in April, may mark a modest expression on the September face of the more dramatic feature on the back side. Ida's dense population of craters shows a wide diversity of morphologies, consistent with the surface having been subjected to saturated bombardment by smaller projectiles. Assuming the same projectile flux applies to Ida was used in deriving Gaspra's cratering age of about 200 m.y., and assuming that Gaspra and Ida both have the same impact strength, then the age of Ida's surface is calculated to be 1-2 b.y. This is considerably older than expected from other evidence concerning the Koronis family. Our favored explanation of Ida's satellite is that it (or a precursor satellite from which the present satellite was derived) formed during the catastrophic disruption event that formed Ida itself and formed the Koronis family of asteroids. Perhaps, instead, the satellite is a block ejected from a cratering impact. In any case, smaller blocks visible on some parts of Ida are more certain to be crater ejecta, whether or not they were ever temporary satellites.

  7. Recognition Code of ZNF191(243-368) and Its Interaction with DNA

    PubMed Central

    Zhao, Dongxin; Huang, Zhongxian

    2015-01-01

    ZNF191(243-368) is the C-terminal region of ZNF191 which contains a putative DNA-binding domain of four Cys2His2 zinc finger motifs. In this study, an expression vector of a fusion protein of ZNF191(243-368) with glutathione-S-transferase (GST) was constructed and transformed into Escherichia coli BL21. The fusion protein GST-ZNF191(243-368) was expressed using this vector to investigate the protein-DNA binding reaction through an affinity selection strategy on the basis of the binding quality of the zinc finger domain. Results showed that ZNF191(243-368) can selectively bind with sequences and react with genes which contain an AGGG core. However, the recognition mechanism of Cys2His2 zinc finger proteins to DNA warrants further investigation. PMID:26457075

  8. 30 CFR 243.100 - What standards must my MMS-specified surety instrument meet?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... INTERIOR MINERALS REVENUE MANAGEMENT SUSPENSIONS PENDING APPEAL AND BONDING-MINERALS REVENUE MANAGEMENT Bonding Requirements § 243.100 What standards must my MMS-specified surety instrument meet? (a) An...

  9. Determination of the 243,246,248Cm thermal neutron induced fission cross sections

    NASA Astrophysics Data System (ADS)

    Serot, O.; Wagemans, C.; Vermote, S.; Heyse, J.; Soldner, T.; Geltenbort, P.

    2005-11-01

    The minor actinide waste produced in nuclear power plants contains various Cm-isotopes, and transmutation scenarios require improved fission cross section data. The available thermal neutron induced fission cross section data for 243Cm, 246Cm and 248Cm are not very accurate, so new cross section measurements have been performed at the high flux reactor of the ILL in Grenoble (France) under better experimental conditions (highly enriched samples, very intense and clean neutron beam). The measurements were performed at a neutron energy of 5.38 meV, yielding fission cross section values of (1240±28)b for 243Cm, (25±47)mb for 246Cm and (685±84)mb for 248Cm. From these results, thermal fission cross section values of (572±14)b; (12±25)mb and (316±43)mb have been deduced for 243Cm, 246Cm and 248Cm, respectively.

  10. 76 FR 13075 - Airworthiness Directives; Airbus Model A330-243F Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-10

    ...-231-AD; Amendment 39-16628; AD 2011-06-04] RIN 2120-AA64 Airworthiness Directives; Airbus Model A330.... ADDRESSES: You may send comments by any of the following methods: Federal eRulemaking Portal: Go to http... AD * * * is issued to extend the applicability to the newly certified model A330-243F. This AD...

  11. 75 FR 52541 - Agency Information Collection Activities: Form I-243, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-26

    ... published in the Federal Register on June 9, 2010, at 75 FR 32799, allowing for a 60-day public comment... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-243, Extension of a Currently Approved Information Collection; Comment Request ACTION: 30-Day Notice...

  12. 40 CFR 52.243 - Interim approval of the Carbon Monoxide plan for the South Coast.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 3 2014-07-01 2014-07-01 false Interim approval of the Carbon Monoxide... § 52.243 Interim approval of the Carbon Monoxide plan for the South Coast. The Carbon Monoxide plan for... such earlier date the State has submitted as a SIP revision a demonstration that the carbon...

  13. 40 CFR 52.243 - Interim approval of the Carbon Monoxide plan for the South Coast.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 3 2013-07-01 2013-07-01 false Interim approval of the Carbon Monoxide... § 52.243 Interim approval of the Carbon Monoxide plan for the South Coast. The Carbon Monoxide plan for... such earlier date the State has submitted as a SIP revision a demonstration that the carbon...

  14. 40 CFR 52.243 - Interim approval of the Carbon Monoxide plan for the South Coast.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 3 2012-07-01 2012-07-01 false Interim approval of the Carbon Monoxide... § 52.243 Interim approval of the Carbon Monoxide plan for the South Coast. The Carbon Monoxide plan for... such earlier date the State has submitted as a SIP revision a demonstration that the carbon...

  15. 40 CFR 52.243 - Interim approval of the Carbon Monoxide plan for the South Coast.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 3 2011-07-01 2011-07-01 false Interim approval of the Carbon Monoxide... § 52.243 Interim approval of the Carbon Monoxide plan for the South Coast. The Carbon Monoxide plan for... such earlier date the State has submitted as a SIP revision a demonstration that the carbon...

  16. 40 CFR 52.243 - Interim approval of the Carbon Monoxide plan for the South Coast.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 3 2010-07-01 2010-07-01 false Interim approval of the Carbon Monoxide... § 52.243 Interim approval of the Carbon Monoxide plan for the South Coast. The Carbon Monoxide plan for... such earlier date the State has submitted as a SIP revision a demonstration that the carbon...

  17. 18 CFR 367.101 - Accounts 231-243, Current and accrued liabilities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., Current and accrued liabilities. 367.101 Section 367.101 Conservation of Power and Water Resources FEDERAL... NATURAL GAS ACT Special Instructions § 367.101 Accounts 231-243, Current and accrued liabilities. Current...; compensation awards, which must be classified as current liabilities regardless of date due; and minor...

  18. 18 CFR 367.101 - Accounts 231-243, Current and accrued liabilities.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., Current and accrued liabilities. 367.101 Section 367.101 Conservation of Power and Water Resources FEDERAL... NATURAL GAS ACT Special Instructions § 367.101 Accounts 231-243, Current and accrued liabilities. Current...; compensation awards, which must be classified as current liabilities regardless of date due; and minor...

  19. 18 CFR 367.2430 - Account 243, Obligations under capital leases-Current.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., Obligations under capital leases-Current. 367.2430 Section 367.2430 Conservation of Power and Water Resources... POWER ACT AND NATURAL GAS ACT Balance Sheet Chart of Accounts Current and Accrued Liabilities § 367.2430 Account 243, Obligations under capital leases—Current. This account must include the portion, due...

  20. 18 CFR 367.101 - Accounts 231-243, Current and accrued liabilities.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., Current and accrued liabilities. 367.101 Section 367.101 Conservation of Power and Water Resources FEDERAL... NATURAL GAS ACT Special Instructions § 367.101 Accounts 231-243, Current and accrued liabilities. Current...; compensation awards, which must be classified as current liabilities regardless of date due; and minor...

  1. 18 CFR 367.101 - Accounts 231-243, Current and accrued liabilities.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., Current and accrued liabilities. 367.101 Section 367.101 Conservation of Power and Water Resources FEDERAL... NATURAL GAS ACT Special Instructions § 367.101 Accounts 231-243, Current and accrued liabilities. Current...; compensation awards, which must be classified as current liabilities regardless of date due; and minor...

  2. 18 CFR 367.101 - Accounts 231-243, Current and accrued liabilities.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., Current and accrued liabilities. 367.101 Section 367.101 Conservation of Power and Water Resources FEDERAL... NATURAL GAS ACT Special Instructions § 367.101 Accounts 231-243, Current and accrued liabilities. Current...; compensation awards, which must be classified as current liabilities regardless of date due; and minor...

  3. 18 CFR 367.2430 - Account 243, Obligations under capital leases-Current.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., Obligations under capital leases-Current. 367.2430 Section 367.2430 Conservation of Power and Water Resources... POWER ACT AND NATURAL GAS ACT Balance Sheet Chart of Accounts Current and Accrued Liabilities § 367.2430 Account 243, Obligations under capital leases—Current. This account must include the portion, due...

  4. 18 CFR 367.2430 - Account 243, Obligations under capital leases-Current.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., Obligations under capital leases-Current. 367.2430 Section 367.2430 Conservation of Power and Water Resources... POWER ACT AND NATURAL GAS ACT Balance Sheet Chart of Accounts Current and Accrued Liabilities § 367.2430 Account 243, Obligations under capital leases—Current. This account must include the portion, due...

  5. 18 CFR 367.2430 - Account 243, Obligations under capital leases-Current.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., Obligations under capital leases-Current. 367.2430 Section 367.2430 Conservation of Power and Water Resources... POWER ACT AND NATURAL GAS ACT Balance Sheet Chart of Accounts Current and Accrued Liabilities § 367.2430 Account 243, Obligations under capital leases—Current. This account must include the portion, due...

  6. 18 CFR 367.2430 - Account 243, Obligations under capital leases-Current.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., Obligations under capital leases-Current. 367.2430 Section 367.2430 Conservation of Power and Water Resources... POWER ACT AND NATURAL GAS ACT Balance Sheet Chart of Accounts Current and Accrued Liabilities § 367.2430 Account 243, Obligations under capital leases—Current. This account must include the portion, due...

  7. 25 CFR 243.2 - What terms do I need to know?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.2 What terms do I need to know? Act means the Reindeer Act of September 1, 1937 (50 Stat. 900; 25 U.S.C. 500 et.... Alaskan reindeer means: (1) All reindeer descended from those present in Alaska at the time of passage...

  8. 25 CFR 243.1 - What is the purpose of this part?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.1... responsibility of Alaska Natives in all branches of the reindeer industry and business in Alaska, and to preserve... acquisition and transferring reindeer and reindeer products in Alaska....

  9. 25 CFR 243.2 - What terms do I need to know?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.2 What terms do I need to know? Act means the Reindeer Act of September 1, 1937 (50 Stat. 900; 25 U.S.C. 500 et.... Alaskan reindeer means: (1) All reindeer descended from those present in Alaska at the time of passage...

  10. 25 CFR 243.1 - What is the purpose of this part?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.1... responsibility of Alaska Natives in all branches of the reindeer industry and business in Alaska, and to preserve... acquisition and transferring reindeer and reindeer products in Alaska....

  11. 25 CFR 243.1 - What is the purpose of this part?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.1... responsibility of Alaska Natives in all branches of the reindeer industry and business in Alaska, and to preserve... acquisition and transferring reindeer and reindeer products in Alaska....

  12. 25 CFR 243.1 - What is the purpose of this part?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.1... responsibility of Alaska Natives in all branches of the reindeer industry and business in Alaska, and to preserve... acquisition and transferring reindeer and reindeer products in Alaska....

  13. 25 CFR 243.2 - What terms do I need to know?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.2 What terms do I need to know? Act means the Reindeer Act of September 1, 1937 (50 Stat. 900; 25 U.S.C. 500 et.... Alaskan reindeer means: (1) All reindeer descended from those present in Alaska at the time of passage...

  14. 25 CFR 243.5 - Who can own imported reindeer, and what limitations apply?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true Who can own imported reindeer, and what limitations apply... REINDEER IN ALASKA § 243.5 Who can own imported reindeer, and what limitations apply? (a) Anyone, including non-Natives, may own imported reindeer in Alaska for any legitimate purpose, subject to State...

  15. 25 CFR 243.1 - What is the purpose of this part?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.1... responsibility of Alaska Natives in all branches of the reindeer industry and business in Alaska, and to preserve... acquisition and transferring reindeer and reindeer products in Alaska....

  16. 25 CFR 243.2 - What terms do I need to know?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.2 What terms do I need to know? Act means the Reindeer Act of September 1, 1937 (50 Stat. 900; 25 U.S.C. 500 et.... Alaskan reindeer means: (1) All reindeer descended from those present in Alaska at the time of passage...

  17. 25 CFR 243.5 - Who can own imported reindeer, and what limitations apply?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Who can own imported reindeer, and what limitations apply... REINDEER IN ALASKA § 243.5 Who can own imported reindeer, and what limitations apply? (a) Anyone, including non-Natives, may own imported reindeer in Alaska for any legitimate purpose, subject to State...

  18. 25 CFR 243.5 - Who can own imported reindeer, and what limitations apply?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Who can own imported reindeer, and what limitations apply... REINDEER IN ALASKA § 243.5 Who can own imported reindeer, and what limitations apply? (a) Anyone, including non-Natives, may own imported reindeer in Alaska for any legitimate purpose, subject to State...

  19. 25 CFR 243.5 - Who can own imported reindeer, and what limitations apply?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Who can own imported reindeer, and what limitations apply... REINDEER IN ALASKA § 243.5 Who can own imported reindeer, and what limitations apply? (a) Anyone, including non-Natives, may own imported reindeer in Alaska for any legitimate purpose, subject to State...

  20. 25 CFR 243.2 - What terms do I need to know?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.2 What terms do I need to know? Act means the Reindeer Act of September 1, 1937 (50 Stat. 900; 25 U.S.C. 500 et.... Alaskan reindeer means: (1) All reindeer descended from those present in Alaska at the time of passage...

  1. 25 CFR 243.5 - Who can own imported reindeer, and what limitations apply?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Who can own imported reindeer, and what limitations apply... REINDEER IN ALASKA § 243.5 Who can own imported reindeer, and what limitations apply? (a) Anyone, including non-Natives, may own imported reindeer in Alaska for any legitimate purpose, subject to State...

  2. Development of cell lines from the sheep used to construct the CHORI-243 ovine BAC library

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Two cell lines, designated MARC.OVSM and MARC.OKF, were initiated from the aorta and kidney, respectively, obtained from the Texel ram used to make the CHORI-243 Ovine BAC library. These cell lines have been submitted to the NIA Aging Cell Repository at the Coriell Cell Respositories, Camden, NJ, U...

  3. 17 CFR 243.103 - No effect on Exchange Act reporting status.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... filings in a timely manner; or (b) There is adequate current public information about the issuer for... a public disclosure required solely by § 243.100 shall not affect whether: (a) For purposes of Forms S-2 (17 CFR 239.12), S-3 (17 CFR 239.13) and S-8 (17 CFR 239.16b) under the Securities Act,...

  4. 20 CFR 702.243 - Settlement application; how submitted, how approved, how disapproved, criteria.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... ADMINISTRATION, DEPARTMENT OF LABOR LONGSHOREMEN'S AND HARBOR WORKERS' COMPENSATION ACT AND RELATED STATUTES ADMINISTRATION AND PROCEDURE Claims Procedures Agreed Settlements § 702.243 Settlement application; how submitted... necessity of future medical treatment (where the settlement includes medical benefits). (g) In cases...

  5. 48 CFR 1652.243-70 - Changes-Negotiated benefits contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Changes-Negotiated... CLAUSES Texts of FEHBP Clauses 1652.243-70 Changes—Negotiated benefits contracts. As prescribed in section 1643.205-70, the following clause shall be inserted in all FEHBP contracts. Changes—Negotiated...

  6. 5 CFR 532.243 - Consultation with the agency wage committee.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Consultation with the agency wage... REGULATIONS PREVAILING RATE SYSTEMS Prevailing Rate Determinations § 532.243 Consultation with the agency wage committee. (a) The lead agency shall submit to the agency wage committee: (1) The data collected in the...

  7. 5 CFR 532.243 - Consultation with the agency wage committee.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Consultation with the agency wage... REGULATIONS PREVAILING RATE SYSTEMS Prevailing Rate Determinations § 532.243 Consultation with the agency wage committee. (a) The lead agency shall submit to the agency wage committee: (1) The data collected in the...

  8. 40 CFR 81.243 - Central Minnesota Intrastate Air Quality Control Region.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 18 2014-07-01 2014-07-01 false Central Minnesota Intrastate Air... Air Quality Control Regions § 81.243 Central Minnesota Intrastate Air Quality Control Region. The Central Minnesota Intrastate Air Quality Control Region consists of the territorial area encompassed...

  9. 40 CFR 81.243 - Central Minnesota Intrastate Air Quality Control Region.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Central Minnesota Intrastate Air... Air Quality Control Regions § 81.243 Central Minnesota Intrastate Air Quality Control Region. The Central Minnesota Intrastate Air Quality Control Region consists of the territorial area encompassed...

  10. 40 CFR 81.243 - Central Minnesota Intrastate Air Quality Control Region.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 17 2011-07-01 2011-07-01 false Central Minnesota Intrastate Air... Air Quality Control Regions § 81.243 Central Minnesota Intrastate Air Quality Control Region. The Central Minnesota Intrastate Air Quality Control Region consists of the territorial area encompassed...

  11. 40 CFR 81.243 - Central Minnesota Intrastate Air Quality Control Region.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 18 2013-07-01 2013-07-01 false Central Minnesota Intrastate Air... Air Quality Control Regions § 81.243 Central Minnesota Intrastate Air Quality Control Region. The Central Minnesota Intrastate Air Quality Control Region consists of the territorial area encompassed...

  12. 40 CFR 81.243 - Central Minnesota Intrastate Air Quality Control Region.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 18 2012-07-01 2012-07-01 false Central Minnesota Intrastate Air... Air Quality Control Regions § 81.243 Central Minnesota Intrastate Air Quality Control Region. The Central Minnesota Intrastate Air Quality Control Region consists of the territorial area encompassed...

  13. 76 FR 63159 - Airworthiness Directives; Airbus Model A330-243F Airplanes Equipped With Rolls Royce Trent 700...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-12

    ...-243F Airplanes Equipped With Rolls Royce Trent 700 Series Engines AGENCY: Federal Aviation... AD applies to Airbus Model A330-243F airplanes; certificated in any category; equipped with Rolls... 39-12221 (66 FR 23838, May 10, 2001] * * * is issued to extend the applicability to the...

  14. 20 CFR 404.243 - Computation where you are eligible for a pension based on noncovered employment.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... pension based on noncovered employment. 404.243 Section 404.243 Employees' Benefits SOCIAL SECURITY... for a pension based on noncovered employment. The provisions of § 404.213 are applicable to... of living amount), minus one-half the portion of your monthly pension which is due to noncovered...

  15. 20 CFR 404.243 - Computation where you are eligible for a pension based on noncovered employment.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... pension based on noncovered employment. 404.243 Section 404.243 Employees' Benefits SOCIAL SECURITY... for a pension based on noncovered employment. The provisions of § 404.213 are applicable to... of living amount), minus one-half the portion of your monthly pension which is due to noncovered...

  16. 25 CFR 1000.243 - What special provisions must be included in an AFA that contains a construction program?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false What special provisions must be included in an AFA that contains a construction program? 1000.243 Section 1000.243 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ANNUAL FUNDING AGREEMENTS UNDER THE TRIBAL SELF-GOVERNMENT...

  17. 30 CFR 243.101 - How will MMS determine the amount of my bond or other surety instrument?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How will MMS determine the amount of my bond or other surety instrument? 243.101 Section 243.101 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT SUSPENSIONS PENDING APPEAL AND BONDING-MINERALS REVENUE MANAGEMENT Bonding Requirements §...

  18. 30 CFR 243.10 - When will MMS collect against a bond or other surety instrument or a person demonstrating...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false When will MMS collect against a bond or other surety instrument or a person demonstrating financial solvency? 243.10 Section 243.10 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT SUSPENSIONS PENDING APPEAL AND BONDING-MINERALS...

  19. 30 CFR 243.12 - May I substitute a demonstration of financial solvency for a bond posted before the effective...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false May I substitute a demonstration of financial solvency for a bond posted before the effective date of this rule? 243.12 Section 243.12 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT SUSPENSIONS PENDING APPEAL AND BONDING-MINERALS...

  20. Effect of His-Tag on Expression, Purification, and Structure of Zinc Finger Protein, ZNF191(243-368)

    PubMed Central

    Huang, Zhongxian

    2016-01-01

    Zinc finger proteins are associated with hereditary diseases and cancers. To obtain an adequate amount of zinc finger proteins for studying their properties, structure, and functions, many protein expression systems are used. ZNF191(243-368) is a zinc finger protein and can be fused with His-tag to generate fusion proteins such as His6-ZNF191(243-368) and ZNF191(243-368)-His8. The purification of His-tag protein using Ni-NTA resin can overcome the difficulty of ZNF191(243-368) separation caused by inclusion body formation. The influences of His-tag on ZNF191(243-368) properties and structure were investigated using spectrographic techniques and hydrolase experiment. Our findings suggest that insertion of a His-tag at the N-terminal or C-terminal end of ZNF191(243-368) has different effects on the protein. Therefore, an expression system should be considered based on the properties and structure of the protein. Furthermore, the hydrolase activity of ZNF191(243-368)-His8 has provided new insights into the design of biological functional molecules. PMID:27524954

  1. Direct high-precision mass measurements on Am241,243, Pu244, and Cf249

    NASA Astrophysics Data System (ADS)

    Eibach, M.; Beyer, T.; Blaum, K.; Block, M.; Düllmann, Ch. E.; Eberhardt, K.; Grund, J.; Nagy, Sz.; Nitsche, H.; Nörtershäuser, W.; Renisch, D.; Rykaczewski, K. P.; Schneider, F.; Smorra, C.; Vieten, J.; Wang, M.; Wendt, K.

    2014-06-01

    The absolute masses of four long-lived transuranium nuclides, Am241,243, Pu244, Pu244, and Cf249, in the vicinity of the deformed N =152 neutron shell closure have been measured directly with the Penning-trap mass spectrometer TRIGA-TRAP. Our measurements confirm the AME2012 mass values of Am241,243 and Pu244 within one standard deviation, which were indirectly determined, by decay spectroscopy studies. In the case of the Cf249 mass, a discrepancy of more than three standard deviations has been observed, affecting absolute masses even in the superheavy element region. The implementation of the mass values into the AME2012 network yields a reduced mass uncertainty for 84 nuclides, particularly for Pu244 and its strongly correlated α decay chains.

  2. Bulk density of asteroid 243 Ida from the orbit of its satellite Dactyl

    USGS Publications Warehouse

    Belton, M.J.S.; Chapman, C.R.; Thomas, P.C.; Davies, M.E.; Greenberg, R.; Klaasen, K.; Byrnes, D.; D'Amario, L.; Synnott, S.; Johnson, T.V.; McEwen, A.; Merline, W.J.; Davis, D.R.; Petit, J.-M.; Storrs, A.; Veverka, J.; Zellner, B.

    1995-01-01

    DURING its reconnaissance of the asteroid 243 Ida, the Galileo spacecraft returned images of a second object, 1993(243)1 Dactyl1 - the first confirmed satellite of an asteroid. Sufficient data were obtained on the motion of Dactyl to determine its orbit as a function of Ida's mass. Here we apply statistical and dynamical arguments to constrain the range of possible orbits, and hence the mass of Ida. Combined with the volume of Ida2, this yields a bulk density of 2.6 ?? 0.5 g cm-3. Allowing for the uncertainty in the porosity of Ida, this density range is consistent with a bulk chon-dritic composition, and argues against some (but not all) classes of meteoritic igneous rock types that have been suggested as compositionally representative of S-type asteroids like Ida. ?? 2002 Nature Publishing Group.

  3. Bulk density of asteroid 243 Ida from the orbit of its satellite Dactyl

    USGS Publications Warehouse

    Belton, M.J.S.; Chapmant, C.R.; Thomas, P.C.; Davies, M.E.; Greenberg, R.; Klaasen, K.; Byrnes, D.; D'Amario, L.; Synnott, S.; Johnson, T.V.; McEwen, A.; Merline, W.J.; Davis, D.R.; Petit, J.-M.; Storrs, A.; Veverka, J.; Zellner, B.

    1995-01-01

    DURING its reconnaissance of the asteroid 243 Ida, the Galileo spacecraft returned images of a second object, 1993(243)1 Dactyl1 - the first confirmed satellite of an asteroid. Sufficient data were obtained on the motion of Dactyl to determine its orbit as a function of Ida's mass. Here we apply statistical and dynamical arguments to constrain the range of possible orbits, and hence the mass of Ida. Combined with the volume of Ida2, this yields a bulk density of 2.6??0.5 g cm-3. Allowing for the uncertainty in the porosity of Ida, this density range is consistent with a bulk chondritic composition, and argues against some (but not all) classes of meteoritic igneous rock types that have been suggested as compositionally representative of S-type asteroids like Ida.

  4. An Unusual Stress Metabolite from a Hydrothermal Vent Fungus Aspergillus sp. WU 243 Induced by Cobalt.

    PubMed

    Ding, Chihong; Wu, Xiaodan; Auckloo, Bibi Nazia; Chen, Chen-Tung Arthur; Ye, Ying; Wang, Kuiwu; Wu, Bin

    2016-01-01

    A novel hybrid polyketide-terpenoid, aspergstressin (1), possessing a unique fused polycyclic structure, was induced from culture broth of strain Aspergillus sp. WU 243 by cobalt ion stimulation. The strain was isolated from the digestive gland of Xenograpsus testudinatus, a unique type of crab which dwells in the Kueishantao hydrothermal vents off Taiwan. The chemical structure and relative configuration of the stress metabolite were established by spectroscopic means. Aspergillus sp. WU 243 produced aspergstressin (1) only under cobalt stressed culture conditions. The results show that stress-driven discovery of new natural products from hydrothermal vent fungi is an effective strategy to unveil the untapped reservoir of small molecules from species found in the hydrothermal vent environment. PMID:26805789

  5. An Unusual Stress Metabolite from a Hydrothermal Vent Fungus Aspergillus sp. WU 243 Induced by Cobalt.

    PubMed

    Ding, Chihong; Wu, Xiaodan; Auckloo, Bibi Nazia; Chen, Chen-Tung Arthur; Ye, Ying; Wang, Kuiwu; Wu, Bin

    2016-01-01

    A novel hybrid polyketide-terpenoid, aspergstressin (1), possessing a unique fused polycyclic structure, was induced from culture broth of strain Aspergillus sp. WU 243 by cobalt ion stimulation. The strain was isolated from the digestive gland of Xenograpsus testudinatus, a unique type of crab which dwells in the Kueishantao hydrothermal vents off Taiwan. The chemical structure and relative configuration of the stress metabolite were established by spectroscopic means. Aspergillus sp. WU 243 produced aspergstressin (1) only under cobalt stressed culture conditions. The results show that stress-driven discovery of new natural products from hydrothermal vent fungi is an effective strategy to unveil the untapped reservoir of small molecules from species found in the hydrothermal vent environment. PMID:26784166

  6. Statistical properties of 243Pu, and 242Pu(n ,γ ) cross section calculation

    NASA Astrophysics Data System (ADS)

    Laplace, T. A.; Zeiser, F.; Guttormsen, M.; Larsen, A. C.; Bleuel, D. L.; Bernstein, L. A.; Goldblum, B. L.; Siem, S.; Garotte, F. L. Bello; Brown, J. A.; Campo, L. Crespo; Eriksen, T. K.; Giacoppo, F.; Görgen, A.; Hadyńska-KlÈ©k, K.; Henderson, R. A.; Klintefjord, M.; Lebois, M.; Renstrøm, T.; Rose, S. J.; Sahin, E.; Tornyi, T. G.; Tveten, G. M.; Voinov, A.; Wiedeking, M.; Wilson, J. N.; Younes, W.

    2016-01-01

    The level density and γ -ray strength function (γ SF ) of 243Pu have been measured in the quasicontinuum using the Oslo method. Excited states in 243Pu were populated using the 242Pu(d ,p ) reaction. The level density closely follows the constant-temperature level density formula for excitation energies above the pairing gap. The γ SF displays a double-humped resonance at low energy as also seen in previous investigations of actinide isotopes. The structure is interpreted as the scissors resonance and has a centroid of ωSR=2.42 (5 ) MeV and a total strength of BSR=10.1 (15 ) μN2 , which is in excellent agreement with sum-rule estimates. The measured level density and γ SF were used to calculate the 242Pu(n ,γ ) cross section in a neutron energy range for which there were previously no measured data.

  7. Spectroscopic monitoring of the luminous blue variable Westerlund1-243 from 2002 to 2009

    NASA Astrophysics Data System (ADS)

    Ritchie, B. W.; Clark, J. S.; Negueruela, I.; Najarro, F.

    2009-12-01

    Context: The massive post-main sequence star W243 in the galactic starburst cluster Westerlund 1 has undergone a spectral transformation from a B2Ia supergiant devoid of emission features in 1981 to an A-type supergiant with a rich emission-line spectrum by 2002/03. Aims: We examine the continued evolution of W243 from 2002 to 2009 to understand its evolutionary state, current physical properties and the origin of its peculiar emission line spectrum. Methods: We used VLT/UVES and VLT/FLAMES to obtain high resolution, high signal-to-noise spectra on six epochs in 2003/04 (UVES) and ten epochs in 2008/09 (FLAMES). These spectra are used alongside other lower-resolution VLT/FLAMES and NTT/EMMI spectra to follow the evolution of W243 from 2002 to 2009. Non-LTE models are used to determine the physical properties of W243. Results: W243 displays a complex, time-varying spectrum with emission lines of hydrogen, helium and Lyman-α pumped metals, forbidden lines of nitrogen and iron, and a large number of absorption lines from neutral and singly-ionized metals. Many lines are complex emission/absorption blends, with significant spectral evolution occurring on timescales of just a few days. The LBV has a temperature of ~8500 K (spectral type A3Ia+), and displays signs of photospheric pulsations and weak episodic mass loss. Nitrogen is highly overabundant, with carbon and oxygen depleted, indicative of surface CNO-processed material and considerable previous mass-loss, although current time-averaged mass-loss rates are low. The emission-line spectrum forms at large radii, when material lost by the LBV in a previous mass-loss event is ionized by an unseen hot companion. Monitoring of the near-infrared spectrum suggests that the star has not changed significantly since it finished evolving to the cool state, close to the Humphreys-Davidson limit, in early 2003. This work is based on observations collected at the European Southern Observatory, Chile, under programme IDs ESO 69

  8. Optimizing tumor targeting of the lipophilic EGFR-binding radiotracer SKI 243 using a liposomal nanoparticle delivery system.

    PubMed

    Medina, Oula Penate; Pillarsetty, Nagavarakishore; Glekas, Athanasios; Punzalan, Blesida; Longo, Valerie; Gönen, Mithat; Zanzonico, Pat; Smith-Jones, Peter; Larson, Steven M

    2011-02-10

    Positron emission tomography (PET) of epidermal growth factor receptor (EGFR) kinase-specific radiolabeled tracers could provide a means for non-invasively characterizing EGFR expression and signaling activity in patients' tumors before, during, and after therapy with EGFR inhibitors. Towards this goal, our group has developed PET tracers which irreversibly bind to EGFR. However, tumor uptake is relatively low because of both the lipophilicity of such tracers (e.g. the morpholino-[124I]-IPQA [SKI 212243]), with octanol-to-water partition coefficients of up to 4, and a short dwell time in the blood and significant hepatobiliary clearance and intestinal reuptake. Liposomal nanoparticle delivery systems may favorably alter the pharmacokinetic profile and improve tumor targeting of highly lipophilic but otherwise promising cancer imaging tracers, such as the EGFR inhibitor SKI 243. SKI 243 is therefore an interesting model molecule for incorporation into lipid-based nanoparticles, as it would not only improve their solubility but also increase the circulation time, availability and, potentially, targeting of tumors. In the current study, we compared the pharmacokinetics and tumor targeting of the bare EGFR kinase-targeting radiotracer SKI 212243 (SKI 243) with that of the same tracer embedded in liposomes. SKI 243 and liposomal SKI 243 are both taken up by tumor xenografts but liposomal SKI 243 remained in the blood longer and consequently exhibited a 3- to 6-fold increase in uptake in the tumor among several other organs. PMID:21047536

  9. Optimizing tumor targeting of the lipophilic EGFR-binding radiotracer SKI243 using a liposomal nanoparticle delivery system

    PubMed Central

    Pillarsetty, Nagavarakishore; Glekas, Athanasios; Punzalan, Blesida; Longo, Valerie; Gönen, Mithat; Zanzonico, Pat; Smith-Jones, Peter

    2015-01-01

    Positron emission tomography (PET) of epidermal growth factor receptor (EGFR) kinase-specific radiolabeled tracers could provide a means for non-invasively characterizing EGFR expression and signaling activity in patients' tumors before, during, and after therapy with EGFR inhibitors. Towards this goal, our group has developed PET tracers which irreversibly bind to EGFR. However, tumor uptake is relatively low because of both the lipophilicity of such tracers (e.g. the morpholino-[124I]-IPQA [SKI212243]), with octanol-to-water partition coefficients of up to 4, and a short dwell time in the blood and significant hepatobiliary clearance and intestinal reuptake. Liposomal nanoparticle delivery systems may favorably alter the pharmacokinetic profile and improve tumor targeting of highly lipophilic but otherwise promising cancer imaging tracers, such as the EGFR inhibitor SKI243. SKI243 is therefore an interesting model molecule for incorporation into lipid-based nanoparticles, as it would not only improve their solubility but also increase the circulation time, availability and, potentially, targeting of tumors. In the current study, we compared the pharmacokinetics and tumor targeting of the bare EGFR kinase-targeting radiotracer SKI212243 (SKI243) with that of the same tracer embedded in liposomes. SKI243 and liposomal SKI243 are both taken up by tumor xenografts but liposomal SKI243 remained in the blood longer and consequently exhibited a 3- to 6-fold increase in uptake in the tumor among several other organs. PMID:21047536

  10. Joint Institute for Nuclear Research Data Analysis Guide - Berkelium Edition

    SciTech Connect

    Henderson, R A

    2009-07-23

    This is a data analysis guide to the JINR system developed by Roger Henderson. It is intended as a complete guide to the data format and the calibration parameters utilized for the analysis of the data. This guide will provide the basic structure of the data files, the description of the individual data items, and the basic equations developed for the calculation of the results. Currently (7/17/2009), calculation of the calibration parameters is not a covered topic. It is intended that this will be covered in a future update.

  11. Aircraft measurement of radio frequency noise at 121.5 MHz, 243MHz and 406MHz

    NASA Technical Reports Server (NTRS)

    Taylor, R. E.; Hill, J. S.

    1977-01-01

    An airborne survey measurement of terrestrial radio-frequency noise over U.S. metropolitan areas has been made at 121.5, 243 and 406 MHz with horizontal-polarization monopole antennas. Flights were at 25,000 feet altitude during the period from December 30, 1976 to January 8, 1977. Radio-noise measurements, expressed in equivalent antenna-noise temperature, indicate a steady-background noise temperature of 572,000 K, at 121.5 MHz, during daylight over New York City. This data is helpful in compiling radio-noise temperature maps; in turn useful for designing satellite-aided, emergency-distress search and rescue communication systems.

  12. Photochemical effects in 243-nm two-photon excitation of atomic hydrogen in flames.

    PubMed

    Goldsmith, J E

    1989-03-15

    This paper describes photochemical effects observed during two-photon 1S-2S excitation of atomic hydrogen in flames using 243-nm laser radiation. An I(4) intensity dependence is observed in regions of the flame where the natural atomic concentration is low, suggesting an I(2) photochemical production mechanism, which we believe is due to two-photon excitation of water molecules, which then predissociate to form H and OH fragments. In a measurement of OH created in the flame by the 243-nm beam, we observe the same I(2) intensity dependence with the laser detuned from the atomic hydrogen 1S-2S resonance, but an apparent I(3.4) dependence is observed when the laser is tuned to the resonance. We believe that a second photochemical mechanism contributes at the resonance, namely, two-photon excitation of H, followed by collisional energy transfer to water molecules, which then fall apart into H and OH fragments. We model this process and show that a combination of I(2) and I(4) dependences can lead to an intensity dependence that mimics a single I(3.4) dependence over a limited range of intensities. PMID:20548641

  13. CHARGE association in a child with de novo inverted duplication (14) (q22{r_arrow}q24.3)

    SciTech Connect

    North, K.N.; Wu, Bai Lin; Cao, B.N.

    1995-07-17

    We report on a 4-{1/2} year old girl with apparent CHARGE association who had a de novo inverted duplication (14) (q22{r_arrow}24.3), iris colobomas, ventricular septal defect, soft tissue choanal atresia, intellectual impairment, growth retardation, sensorineural deafness, apparently low set ears, and upslanting palpebral fissures. Family history was unremarkable and parental chromosomes were normal. Similarities between this and previously reported cases of 14q duplication suggest that a locus for a gene or genes causing some of the anomalies of CHARGE association may reside in the region 14q22 to 24.3. 26 refs., 2 figs., 1 tab.

  14. Study of Methods for Producing a Tunable UV Laser for Spectroscopy at 243nm.

    NASA Astrophysics Data System (ADS)

    Khademian, Ali; Shiner, David

    2002-05-01

    We are beginning an experiment to precisely measure the 1S to 2S interval in atomic tritium. A narrow bandwidth tunable source of several mW at 243nm is required. We seek methods that are less expensive and cumbersome than traditional dye or Ti Sapphire lasers. An all solid state approach has been demonstrated [Zimmermann, Vuletic, Hemmerich and Hansch, Appl. Phys. Lett. 66 p2318, 1995] using a MOPA semiconductor laser with two resonant doubling cavities using KNbO3 and BBO. We study this approach but with possible improvements using PPLN as an alternative to KNbO3 and using CLBO for doubling 486nm as an alternative to BBO. Other IR laser sources are also considered. The current status of our investigations will be presented

  15. Lipoprotein Lipase Deficiency (R243H) in a Type 2 Diabetes Patient with Multiple Arterial Aneurysms.

    PubMed

    Suzuki, Toru; Sawada, Shojiro; Ishigaki, Yasushi; Tsukita, Sohei; Kodama, Shinjiro; Sugisawa, Takashi; Imai, Junta; Yamada, Tetsuya; Yamaguchi, Takashi; Murano, Takeyoshi; Katagiri, Hideki

    2016-01-01

    Lipoprotein lipase (LPL) deficiency is a rare monogenic disorder that manifests as severe hypertriglyceridemia. Whether or not LPL deficiency accelerates the development of atherosclerosis remains controversial. We herein report a 66-year-old woman who was homozygous for the R243H LPL mutation. She had developed multiple arterial aneurysms and systemic atherosclerosis despite good control of other atherogenic risk factors, including diabetes. Furthermore, although intensive pharmaceutical therapies had been minimally effective, medium chain triglyceride (MCT) therapy reduced the serum triglyceride levels. Thus, this case suggests important role that mutated LPL protein plays in the progression of atherosclerosis and that MCT therapy is potentially effective, even for severe hypertriglyceridemia due to LPL deficiency. PMID:27150867

  16. 25 CFR 243.11 - Are transfers of Alaskan reindeer that occurred before issuance of this part valid?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Are transfers of Alaskan reindeer that occurred before... INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.11 Are transfers of Alaskan reindeer that occurred before issuance of this part valid? All transfers of live Alaskan reindeer or reindeer products that...

  17. 25 CFR 243.6 - Which sales or transfers of Alaskan reindeer do not require a permit?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Which sales or transfers of Alaskan reindeer do not... AND WILDLIFE REINDEER IN ALASKA § 243.6 Which sales or transfers of Alaskan reindeer do not require a... reindeer or reindeer products; and (b) Sale of transfer of live reindeer between Alaska Natives or...

  18. 25 CFR 243.6 - Which sales or transfers of Alaskan reindeer do not require a permit?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Which sales or transfers of Alaskan reindeer do not... AND WILDLIFE REINDEER IN ALASKA § 243.6 Which sales or transfers of Alaskan reindeer do not require a... reindeer or reindeer products; and (b) Sale of transfer of live reindeer between Alaska Natives or...

  19. 25 CFR 243.6 - Which sales or transfers of Alaskan reindeer do not require a permit?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true Which sales or transfers of Alaskan reindeer do not... AND WILDLIFE REINDEER IN ALASKA § 243.6 Which sales or transfers of Alaskan reindeer do not require a... reindeer or reindeer products; and (b) Sale of transfer of live reindeer between Alaska Natives or...

  20. 25 CFR 243.11 - Are transfers of Alaskan reindeer that occurred before issuance of this part valid?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Are transfers of Alaskan reindeer that occurred before... INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.11 Are transfers of Alaskan reindeer that occurred before issuance of this part valid? All transfers of live Alaskan reindeer or reindeer products that...

  1. 25 CFR 243.11 - Are transfers of Alaskan reindeer that occurred before issuance of this part valid?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Are transfers of Alaskan reindeer that occurred before... INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.11 Are transfers of Alaskan reindeer that occurred before issuance of this part valid? All transfers of live Alaskan reindeer or reindeer products that...

  2. 25 CFR 243.11 - Are transfers of Alaskan reindeer that occurred before issuance of this part valid?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Are transfers of Alaskan reindeer that occurred before... INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.11 Are transfers of Alaskan reindeer that occurred before issuance of this part valid? All transfers of live Alaskan reindeer or reindeer products that...

  3. 25 CFR 243.11 - Are transfers of Alaskan reindeer that occurred before issuance of this part valid?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true Are transfers of Alaskan reindeer that occurred before... INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.11 Are transfers of Alaskan reindeer that occurred before issuance of this part valid? All transfers of live Alaskan reindeer or reindeer products that...

  4. 25 CFR 243.6 - Which sales or transfers of Alaskan reindeer do not require a permit?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Which sales or transfers of Alaskan reindeer do not... AND WILDLIFE REINDEER IN ALASKA § 243.6 Which sales or transfers of Alaskan reindeer do not require a... reindeer or reindeer products; and (b) Sale of transfer of live reindeer between Alaska Natives or...

  5. 25 CFR 243.6 - Which sales or transfers of Alaskan reindeer do not require a permit?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Which sales or transfers of Alaskan reindeer do not... AND WILDLIFE REINDEER IN ALASKA § 243.6 Which sales or transfers of Alaskan reindeer do not require a... reindeer or reindeer products; and (b) Sale of transfer of live reindeer between Alaska Natives or...

  6. Physical studies of asteroids. XXIII - Photometric observations of the asteroids 6, 32, 196, 243, 416, 532 and 1580

    NASA Astrophysics Data System (ADS)

    Erikson, A.; Lagerkvist, C.-I.; Lindgren, M.; Cutispoto, G.; Debehogne, H.; Hahn, G.; Magnusson, P.

    1991-12-01

    Photometric studies of seven asteroids observed at the European Southern Observatory (La Sill a, Chile) with the 50 cm ESO telescope are presented. For these asteroids (6 Hebe, 32 Pomona, 196 Philomela, 243 Ida, 416 Vaticana, 532 Herculina and 1580 Betulia) composite lightcurves are presented. Mean colour indexes, calculated for some of the nights, are also given.

  7. 25 CFR 900.243 - What effect will an Indian tribe or tribal organization's retrocession have on its rights to...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false What effect will an Indian tribe or tribal organization's..., DEPARTMENT OF THE INTERIOR, AND INDIAN HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS... Procedures § 900.243 What effect will an Indian tribe or tribal organization's retrocession have on...

  8. 25 CFR 900.243 - What effect will an Indian tribe or tribal organization's retrocession have on its rights to...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 2 2011-04-01 2011-04-01 false What effect will an Indian tribe or tribal organization's..., DEPARTMENT OF THE INTERIOR, AND INDIAN HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS... Procedures § 900.243 What effect will an Indian tribe or tribal organization's retrocession have on...

  9. 30 CFR 243.5 - May another person post a bond or other surety instrument or demonstrate financial solvency on my...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... instrument or demonstrate financial solvency on my behalf? 243.5 Section 243.5 Mineral Resources MINERALS... surety instrument or demonstrate financial solvency on my behalf? Any other person, including a designee, payor, or affiliate, may post a bond or other surety instrument or demonstrate financial solvency...

  10. 49 CFR 40.243 - What is the procedure for an alcohol screening test using an EBT or non-evidential breath ASD?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... test using an EBT or non-evidential breath ASD? 40.243 Section 40.243 Transportation Office of the...-evidential breath ASD? As the BAT or STT, you must take the following steps: (a) Select, or allow the... breath has been obtained. (d) Show the employee the displayed test result. (e) If the device is one...

  11. 49 CFR 40.243 - What is the procedure for an alcohol screening test using an EBT or non-evidential breath ASD?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... test using an EBT or non-evidential breath ASD? 40.243 Section 40.243 Transportation Office of the...-evidential breath ASD? As the BAT or STT, you must take the following steps: (a) Select, or allow the... breath has been obtained. (d) Show the employee the displayed test result. (e) If the device is one...

  12. 49 CFR 40.243 - What is the procedure for an alcohol screening test using an EBT or non-evidential breath ASD?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... test using an EBT or non-evidential breath ASD? 40.243 Section 40.243 Transportation Office of the...-evidential breath ASD? As the BAT or STT, you must take the following steps: (a) Select, or allow the... breath has been obtained. (d) Show the employee the displayed test result. (e) If the device is one...

  13. 49 CFR 40.243 - What is the procedure for an alcohol screening test using an EBT or non-evidential breath ASD?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... test using an EBT or non-evidential breath ASD? 40.243 Section 40.243 Transportation Office of the...-evidential breath ASD? As the BAT or STT, you must take the following steps: (a) Select, or allow the... breath has been obtained. (d) Show the employee the displayed test result. (e) If the device is one...

  14. 49 CFR 40.243 - What is the procedure for an alcohol screening test using an EBT or non-evidential breath ASD?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... test using an EBT or non-evidential breath ASD? 40.243 Section 40.243 Transportation Office of the...-evidential breath ASD? As the BAT or STT, you must take the following steps: (a) Select, or allow the... breath has been obtained. (d) Show the employee the displayed test result. (e) If the device is one...

  15. Phosphorylation of HPV-16 E2 at Serine 243 Enables Binding to Brd4 and Mitotic Chromosomes

    PubMed Central

    Chang, Szu-Wei; Liu, Wei-Chen; Liao, Kuan-Yu; Tsao, Yeou-Ping; Hsu, Pang-Hung; Chen, Show-Li

    2014-01-01

    The papillomavirus E2 protein is involved in the maintenance of persistent infection and known to bind either to cellular factors or directly to mitotic chromosomes in order to partition the viral genome into the daughter cells. However, how the HPV-16 E2 protein acts to facilitate partitioning of the viral genome remains unclear. In this study, we found that serine 243 of HPV-16 E2, located in the hinge region, is crucial for chromosome binding during mitosis. Bromodomain protein 4 (Brd4) has been identified as a cellular binding target through which the E2 protein of bovine papillomavirus type 1 (BPV-1) tethers the viral genome to mitotic chromosomes. Mutation analysis showed that, when the residue serine 243 was substituted by glutamic acid or aspartic acid, whose negative charges mimic the effect of constitutive phosphorylation, the protein still can interact with Brd4 and colocalize with Brd4 in condensed metaphase and anaphase chromosomes. However, substitution by the polar uncharged residues asparagine or glutamine abrogated Brd4 and mitotic chromosome binding. Moreover, following treatment with the inhibitor JQ1 to release Brd4 from the chromosomes, Brd4 and E2 formed punctate foci separate from the chromosomes, further supporting the hypothesis that the association of the HPV-16 E2 protein with the chromosomes is Brd4-dependent. In addition, the S243A E2 protein has a shorter half-life than the wild type, indicating that phosphorylation of the HPV-16 E2 protein at serine 243 also increases its half-life. Thus, phosphorylation of serine 243 in the hinge region of HPV-16 E2 is essential for interaction with Brd4 and required for host chromosome binding. PMID:25340539

  16. Haploinsufficiency of ANKRD11 (16q24.3) Is Not Obligatorily Associated with Cognitive Impairment but Shows a Clinical Overlap with Silver-Russell Syndrome

    PubMed Central

    Spengler, S.; Oehl-Jaschkowitz, B.; Begemann, M.; Hennes, P.; Zerres, K.; Eggermann, T.

    2013-01-01

    Microdeletions in 16q24.3 are associated with intellectual disability and a specific phenotype, e.g. short stature and a prominent forehead. The 16q24.3 microdeletion syndrome shows a broad phenotypic overlap with the KBG syndrome, which is caused by mutations within the ANKRD11 gene. Furthermore, both KBG and the 16q24.3 microdeletion syndromes show clinical findings reminiscent of Silver-Russell syndrome (SRS), an imprinting disorder characterized by severe primordial growth retardation. In a cohort of patients referred as SRS, we previously identified a 16q24.3 deletion, but at that time, only patients with larger imbalances in 16q24.3 and intellectual disability had been published. Considering the recent description of the ANKRD11 gene as the causative factor for the 2 16q24.3-associated disorders, we now classified our patient as a 16q24.3 microdeletion syndrome patient exhibiting some characteristic features but normal intelligence. Our case illustrates the broad clinical spectrum associated with microdeletions, and we confirm that the 16q24.3 microdeletion syndrome is a further microdeletion syndrome with very variable expressivity. Indeed, our case is the first 16q24.3 patient of normal intelligence, but we assume that this variant is present in further mentally healthy probands which have not yet been tested. In conclusion, the detection of the 16q24.3 deletion in a proband of unremarkable intellectual capacities once again illustrates the need to perform molecular karyotyping in dysmorphic patients with normal intelligence. PMID:23885231

  17. Haploinsufficiency of ANKRD11 (16q24.3) Is Not Obligatorily Associated with Cognitive Impairment but Shows a Clinical Overlap with Silver-Russell Syndrome.

    PubMed

    Spengler, S; Oehl-Jaschkowitz, B; Begemann, M; Hennes, P; Zerres, K; Eggermann, T

    2013-06-01

    Microdeletions in 16q24.3 are associated with intellectual disability and a specific phenotype, e.g. short stature and a prominent forehead. The 16q24.3 microdeletion syndrome shows a broad phenotypic overlap with the KBG syndrome, which is caused by mutations within the ANKRD11 gene. Furthermore, both KBG and the 16q24.3 microdeletion syndromes show clinical findings reminiscent of Silver-Russell syndrome (SRS), an imprinting disorder characterized by severe primordial growth retardation. In a cohort of patients referred as SRS, we previously identified a 16q24.3 deletion, but at that time, only patients with larger imbalances in 16q24.3 and intellectual disability had been published. Considering the recent description of the ANKRD11 gene as the causative factor for the 2 16q24.3-associated disorders, we now classified our patient as a 16q24.3 microdeletion syndrome patient exhibiting some characteristic features but normal intelligence. Our case illustrates the broad clinical spectrum associated with microdeletions, and we confirm that the 16q24.3 microdeletion syndrome is a further microdeletion syndrome with very variable expressivity. Indeed, our case is the first 16q24.3 patient of normal intelligence, but we assume that this variant is present in further mentally healthy probands which have not yet been tested. In conclusion, the detection of the 16q24.3 deletion in a proband of unremarkable intellectual capacities once again illustrates the need to perform molecular karyotyping in dysmorphic patients with normal intelligence. PMID:23885231

  18. Complete sequencing and characterization of 21,243 full-length human cDNAs.

    PubMed

    Ota, Toshio; Suzuki, Yutaka; Nishikawa, Tetsuo; Otsuki, Tetsuji; Sugiyama, Tomoyasu; Irie, Ryotaro; Wakamatsu, Ai; Hayashi, Koji; Sato, Hiroyuki; Nagai, Keiichi; Kimura, Kouichi; Makita, Hiroshi; Sekine, Mitsuo; Obayashi, Masaya; Nishi, Tatsunari; Shibahara, Toshikazu; Tanaka, Toshihiro; Ishii, Shizuko; Yamamoto, Jun-ichi; Saito, Kaoru; Kawai, Yuri; Isono, Yuko; Nakamura, Yoshitaka; Nagahari, Kenji; Murakami, Katsuhiko; Yasuda, Tomohiro; Iwayanagi, Takao; Wagatsuma, Masako; Shiratori, Akiko; Sudo, Hiroaki; Hosoiri, Takehiko; Kaku, Yoshiko; Kodaira, Hiroyo; Kondo, Hiroshi; Sugawara, Masanori; Takahashi, Makiko; Kanda, Katsuhiro; Yokoi, Takahide; Furuya, Takako; Kikkawa, Emiko; Omura, Yuhi; Abe, Kumi; Kamihara, Kumiko; Katsuta, Naoko; Sato, Kazuomi; Tanikawa, Machiko; Yamazaki, Makoto; Ninomiya, Ken; Ishibashi, Tadashi; Yamashita, Hiromichi; Murakawa, Katsuji; Fujimori, Kiyoshi; Tanai, Hiroyuki; Kimata, Manabu; Watanabe, Motoji; Hiraoka, Susumu; Chiba, Yoshiyuki; Ishida, Shinichi; Ono, Yukio; Takiguchi, Sumiyo; Watanabe, Susumu; Yosida, Makoto; Hotuta, Tomoko; Kusano, Junko; Kanehori, Keiichi; Takahashi-Fujii, Asako; Hara, Hiroto; Tanase, Tomo-o; Nomura, Yoshiko; Togiya, Sakae; Komai, Fukuyo; Hara, Reiko; Takeuchi, Kazuha; Arita, Miho; Imose, Nobuyuki; Musashino, Kaoru; Yuuki, Hisatsugu; Oshima, Atsushi; Sasaki, Naokazu; Aotsuka, Satoshi; Yoshikawa, Yoko; Matsunawa, Hiroshi; Ichihara, Tatsuo; Shiohata, Namiko; Sano, Sanae; Moriya, Shogo; Momiyama, Hiroko; Satoh, Noriko; Takami, Sachiko; Terashima, Yuko; Suzuki, Osamu; Nakagawa, Satoshi; Senoh, Akihiro; Mizoguchi, Hiroshi; Goto, Yoshihiro; Shimizu, Fumio; Wakebe, Hirokazu; Hishigaki, Haretsugu; Watanabe, Takeshi; Sugiyama, Akio; Takemoto, Makoto; Kawakami, Bunsei; Yamazaki, Masaaki; Watanabe, Koji; Kumagai, Ayako; Itakura, Shoko; Fukuzumi, Yasuhito; Fujimori, Yoshifumi; Komiyama, Megumi; Tashiro, Hiroyuki; Tanigami, Akira; Fujiwara, Tsutomu; Ono, Toshihide; Yamada, Katsue; Fujii, Yuka; Ozaki, Kouichi; Hirao, Maasa; Ohmori, Yoshihiro; Kawabata, Ayako; Hikiji, Takeshi; Kobatake, Naoko; Inagaki, Hiromi; Ikema, Yasuko; Okamoto, Sachiko; Okitani, Rie; Kawakami, Takuma; Noguchi, Saori; Itoh, Tomoko; Shigeta, Keiko; Senba, Tadashi; Matsumura, Kyoka; Nakajima, Yoshie; Mizuno, Takae; Morinaga, Misato; Sasaki, Masahide; Togashi, Takushi; Oyama, Masaaki; Hata, Hiroko; Watanabe, Manabu; Komatsu, Takami; Mizushima-Sugano, Junko; Satoh, Tadashi; Shirai, Yuko; Takahashi, Yukiko; Nakagawa, Kiyomi; Okumura, Koji; Nagase, Takahiro; Nomura, Nobuo; Kikuchi, Hisashi; Masuho, Yasuhiko; Yamashita, Riu; Nakai, Kenta; Yada, Tetsushi; Nakamura, Yusuke; Ohara, Osamu; Isogai, Takao; Sugano, Sumio

    2004-01-01

    As a base for human transcriptome and functional genomics, we created the "full-length long Japan" (FLJ) collection of sequenced human cDNAs. We determined the entire sequence of 21,243 selected clones and found that 14,490 cDNAs (10,897 clusters) were unique to the FLJ collection. About half of them (5,416) seemed to be protein-coding. Of those, 1,999 clusters had not been predicted by computational methods. The distribution of GC content of nonpredicted cDNAs had a peak at approximately 58% compared with a peak at approximately 42%for predicted cDNAs. Thus, there seems to be a slight bias against GC-rich transcripts in current gene prediction procedures. The rest of the cDNAs unique to the FLJ collection (5,481) contained no obvious open reading frames (ORFs) and thus are candidate noncoding RNAs. About one-fourth of them (1,378) showed a clear pattern of splicing. The distribution of GC content of noncoding cDNAs was narrow and had a peak at approximately 42%, relatively low compared with that of protein-coding cDNAs. PMID:14702039

  19. Different Interaction Mechanisms of Eu(III) and (243)Am(III) with Carbon Nanotubes Studied by Batch, Spectroscopy Technique and Theoretical Calculation.

    PubMed

    Wang, Xiangxue; Yang, Shubin; Shi, Weiqun; Li, Jiaxing; Hayat, Tasawar; Wang, Xiangke

    2015-10-01

    Herein the sorption of Eu(III) and (243)Am(III) on multiwalled carbon nanotubes (CNTs) are studied, and the results show that Eu(III) and (243)Am(III) could form strong inner-sphere surface complexes on CNT surfaces. However, the sorption of Eu(III) on CNTs is stronger than that of (243)Am(III) on CNTs, suggesting the difference in the interaction mechanisms or properties of Eu(III) and (243)Am(III) with CNTs, which is quite different from the results of Eu(III) and (243)Am(III) interaction on natural clay minerals and oxides. On the basis of the results of density functional theory calculations, the binding energies of Eu(III) on CNTs are much higher than those of (243)Am(III) on CNTs, indicating that Eu(III) could form stronger complexes with the oxygen-containing functional groups of CNTs than (243)Am(III), which is in good agreement with the experimental results of higher sorption capacity of CNTs for Eu(III). The oxygen-containing functional groups contribute significantly to the uptake of Eu(III) and (243)Am(III), and the binding affinity increases in the order of ≡S-OH < ≡S-COOH < ≡S-COO(-). This paper highlights the interaction mechanism of Eu(III) and (243)Am(III) with different oxygen-containing functional groups of CNTs, which plays an important role for the potential application of CNTs in the preconcentration, removal, and separation of trivalent lanthanides and actinides in environmental pollution cleanup. PMID:26371690

  20. Identification of a gene at 16q24.3 that restores cellular senescence in immortal mammary tumor cells.

    PubMed

    Reddy, D E; Sandhu, A K; DeRiel, J K; Athwal, R S; Kaur, G P

    1999-09-01

    We have mapped a cellular senescence gene, SEN16, within a genetic distance of 3 - 7 cM, at 16q24.3. Microcell mediated transfer of a normal human chromosome 16, 16q22-qter or 16q23-qter restored cellular senescence in four immortal cell lines, derived from human and rat mammary tumors. The resumption of indefinite cell proliferation, concordant with the segregation of the donor chromosome, confirmed the presence of a senescence gene at 16q23-qter. While microcell hybrids were maintained in selection medium to retain the donor chromosome, sporadic immortal revertant clones arose among senescent cells. Reversion to immortal growth could occur due to inactivation of the senescence gene either by a mutation or a deletion. The analysis for chromosome 16 specific DNA markers, in revertant clones of senescent microcell hybrids, revealed a consensus deletion, spanning a genetic interval of approximately 3 - 7 cM at 16q24.3. PMID:10490846

  1. Wilsonville Advanced Coal Liquefaction Research and Development Facility, Wilsonville, Alabama. Technical progress report, Run 243 with Illinois 6 coal

    SciTech Connect

    Not Available

    1984-02-01

    This report presents the operating results for Run 243 at the Advanced Coal Liquefaction R and D Facility in Wilsonville, Alabama. This run was made in an Integrated Two-Stage Liquefaction (ITSL) mode using Illinois 6 coal from the Burning Star mine. The primary objective was to demonstrate the effect of a dissolver on the ITSL product slate, especially on the net C/sub 1/-C/sub 5/ gas production and hydrogen consumption. Run 243 began on 3 February 1983 and continued through 28 June 1983. During this period, 349.8 tons of coal was fed in 2947 hours of operation. Thirteen special product workup material balances were defined, and the results are presented herein. 29 figures, 19 tables.

  2. Overview of NATO/AC 243/Panel 3 activities concerning radiowave propagation in coastal environments

    NASA Astrophysics Data System (ADS)

    Christophe, F.; Douchin, N.; Hurtaud, Y.; Dion, D.; Makaruschka, R.; Heemskerk, H.; Anderson, K.

    1995-02-01

    The performances of most systems operating at RF and millimeter waves can be seriously affected by propagation effects. That is the reason why NATO established the Research Study group No. 8 (RSG8) within Panel 3 (physics and electronics) of Defense Research Group (AC 243), with its Propagation Subgroup (PSG) responsible for the propagation aspects. Comparison of mm and other wavelengths was to be considered. In maritime and coastal environments, the use of such wavelengths for various military applications like anti-ship seekers, fire control radars, ship to ship communications or Electronic Support Measurements (ESM) led to the setting up of specific measurement campaigns; the last three are reported hereafter. The first two experiments used facilities close to Lorient, on the Atlantic coast, and Toulon, on the Mediterranean coast of France, with the purpose of documenting the refractive effects for medium range over the horizon paths. These experiments where are referred to as Lorient 89 and Toulon 90 campaigns, are described in this paper, and some typical results are presented. The latest cooperative work of RSG8/PSG took place recently (fall 1993) near Lorient, on a line-of-sight 10 km path over seawater. This experiment, referred to as Lorient 93 campaign, was devoted to the analysis of phase-front distortions due to multipath along with refractive effects, and to the assessment of performances for naval systems like short range tracking radars. Analysis of the data, either on a statistical base or as specific case studies, is being performed presently, but some early typical results will be given in this paper after a detailed description of the experiment.

  3. Investigating SLIM Disk Solutions FOR HLX-1 IN ESO 243-49

    NASA Technical Reports Server (NTRS)

    Godet, O.; Plazolles, B.; Kawaguchi, T.; Lasota, J.-P; Barret, d.; Farrell, S. A.; Braito, V.; Servillat, M.; Webb, N.; Gehrels, N.

    2012-01-01

    The hyperluminous X-ray source HLX-1 in the galaxy ESO 243-49, currently the best intermediate-mass blackhole (BH) candidate, displays spectral transitions similar to those observed in Galactic BH binaries, but with aluminosity 100-1000 times higher. We investigated the X-ray properties of this unique source by fitting multiepochdata collected by Swift, XMM-Newton, and Chandra with a disk model computing spectra for a wide rangeof sub- and super-Eddington accretion rates assuming a non-spinning BH and a face-on disk (i=0 deg.). Under theseassumptions we find that the BH in HLX-1 is in the intermediate-mass range (approximately 2 x 10(exp 4) solar mass) and the accretionflow is in the sub-Eddington regime. The disk radiation efficiency is eta = 0.11 plus or minus 0.03. We also show that the source does follow the LX is proportional to T(exp 4) relation for our mass estimate. At the outburst peaks, the source radiates near the Eddington limit. The accretion rate then stays constant around 4 x 10(exp 4) solar mass yr (sup -1) for several days and then decreases exponentially. Such plateaus in the accretion rate could be evidence that enhanced mass-transfer rateis the driving outburst mechanism in HLX-1. We also report on the new outburst observed in 2011 August by theSwift X-Ray Telescope. The time of this new outburst further strengthens the approximately 1 year recurrence timescale.

  4. miR-24-3p Suppresses Malignant Behavior of Lacrimal Adenoid Cystic Carcinoma by Targeting PRKCH to Regulate p53/p21 Pathway

    PubMed Central

    Zhang, Hong; Tang, Hua

    2016-01-01

    MicroRNA (miRNA) may function as an oncogene or a tumor suppressor in tumorigenesis. However, the mechanism of miRNAs in adenoid cystic carcinoma (ACC) is unclear. Here, we provide evidence that miR-24-3p was downreglated and functions as a tumor suppressor in human lacrimal adenoid cystic carcinoma by suppressing proliferation and migration/invasion while promoting apoptosis. miR-24-3p down-regulated protein kinase C eta (PRKCH) by binding to its untranslated region (3’UTR). PRKCH increased the of the cell growth and migration/invasion in ACC cells and suppressed the expression of p53 and p21 in both mRNA and protein level. The overexpression of miR-24-3p decreased its malignant phenotype. Ectopic expression of PRKCH counteracted the suppression of malignancy induced by miR-24-3p, as well as ectopic expression of miR-24-3p rescued the suppression of PRKCH in the p53/p21 pathway. These results suggest that miR-24-3p promotes the p53/p21 pathway by down-regulating PRKCH expression in lacrimal adenoid cystic carcinoma cells. PMID:27351203

  5. 243Am + 48Ca: A Second Look at the Rf/Db Data Set

    SciTech Connect

    Henderson, R A; Moody, K J

    2008-01-29

    In December of 2005 a series of experiments were performed at the U400 Cyclotron at the Flerov Laboratory of Nuclear Reactions in Dubna, Russia, using the reaction {sup 243}Am ({sup 48}Ca,3n) {sup 288}115 which, after a sequence of five alpha decays, produces a long-lived ({approx}1d) fission activity that had been detected previously in experiments using the Dubna Gas Filled Recoil Separator (DGFRS). These experiments were attempts to establish the elemental identity of the fissioning species as dubnium (element 105), which in turn confirms the identity of the original parent nucleus as element 115 through genetic correlation of the subsequent alpha decays. A series of approximately 24-hour bombardments were followed by chemical separations designed to isolate the Group Four and Five chemical fractions, and then separate the Nb and Ta fractions, which are Group Five homologues of dubnium and should therefore behave chemically similar. The samples were prepared for alpha and fission measurement and counted for an extended period of time. Fission events were detected in the Ta-like fractions only, which correspond to the fission coming from either the {sup 268}Db isotope directly or long-lived electron-capture decay in {sup 268}Db followed by a short half-life fission of {sup 268}Rf. In May of 2007 the Rf and Db fractions were recounted for very long times on alpha spectrometers to look at what species remained after approximately 1.5 years of time. One of the issues to be resolved was the potential for actinide contamination of the counting samples, which might have adverse affects on the observed data from the original experiment. In the original experiment the samples had significant quantities of {beta}-{gamma} activity which made the absolute identification of the alpha activity in each sample difficult. By allowing the {beta}-{gamma} activity to decay away, it gives us the opportunity to make definitive identifications of any alpha emitting isotopes on the

  6. Implications of the delayed 2013 outburst of ESO 243-49 HLX-1

    SciTech Connect

    Godet, O.; Webb, N. A.; Lombardi, J. C.; Vingless, J.; Thomas, M.; Antonini, F.; Barret, D.

    2014-10-01

    After showing four quasi-periodic outbursts spaced by ∼1 yr from 2009 to 2012, the hyper luminous X-ray source ESO 243-49 HLX-1, currently the best intermediate mass black hole (IMBH) candidate, showed an outburst in 2013 delayed by more than a month. In Lasota et al., we proposed that the X-ray light curve is the result of enhanced mass transfer episodes at periapsis from a donor star orbiting the IMBH in a highly eccentric orbit. In this scenario, the delay can be explained only if the orbital parameters can change suddenly from orbit to orbit. To investigate this, we ran Newtonian smooth particle hydrodynamical simulations starting with an incoming donor approaching an IMBH on a parabolic orbit. We survey a large parameter space by varying the star-to-black hole mass ratio (10{sup –5}-10{sup –3}) and the periapsis separation r{sub p} from 2.2 to 2.7r{sub t} with r{sub t} , the tidal radius. To model the donor, we choose several polytropes (Γ = 5/2, n = 3/2, Γ = 3/2, n = 2, Γ = 5/3, n = 2, and Γ = 5/3, n = 3). Once the system is formed, the orbital period decreases until reaching a minimum that may be shallow. Then, the period tends to increase over several periapsis passages due to tidal effects and increasing mass transfer, leading ultimately to the ejection of the donor. We show that the development of stochastic fluctuations inside the donor by adding or removing orbital energy from the system could lead to sudden changes in the orbital period from orbit to orbit with the appropriate order of magnitude to that which has been observed for HLX-1. We also show that given the constraints on the black hole (BH) mass (M {sub BH} > 10{sup 4} M {sub ☉}) and assuming that the HLX-1 system is currently near a minimum in period of ∼1 yr, the donor has to be a white dwarf or a stripped giant core. We predict that if HLX-1 is indeed emerging from a minimum in orbital period, then the period would generally increase with each passage, although substantial

  7. CHARGE association in a child with de novo inv dup (14)(q22{yields}q24.3)

    SciTech Connect

    North, K.; Wu, B.L.; Whiteman, D.

    1994-09-01

    The CHARGE association is an increasingly recognized complex of multiple malformations, that include Coloboma, Heart defect, choanal Atresia, Retardation of mental and somatic development, hypoplastic Genitalia, and Ear abnormalities or deafness. It has been postulated that many of the defects result from abnormalities in the development, migration or interaction of cells of the cephalic neural crest. The majority of cases are sporadic. We report a case of an inverted duplication (14)(q22{yields}q24.3) associated with CHARGE association. The patient was a 4 {1/2}-year-old female and was the product of a normal pregnancy. Family history was unremarkable. The clinical manifestations included the combination of congenital anomalies (coloboma, ventricular septal defect, severe developmental delay and growth retardation, genital hypoplasia and sensorineural deafness) in association with soft tissue choanal atresia, dysphagia, and minor dysmorphic features (low set ears, upslanting palpebral fissures). High resolution cytogenetic studies revealed that the child has 46,XX,inv dup(14)(q22{yields}q24.3) and parents have normal chromosomes. FISH with a chromosome 14 paint probe confirmed that the duplicated region is entirely derived from chromosome 14. FISH with D22S75 probe for region 22q11.2 detected no deletion for this locus. Several duplications or deletions involving different chromosomes have been reported for patients with conditions resembling CHARGE association. This indicates that CHARGE is possible genetically heterogenous, parallelling the phenotypic heterogeneity of the disorder. Two published cases with unbalanced rearrengements involving 14q22 have some comparable features with our case, which suggests that the locus for a gene causing some of the features of CHARGE association may reside at 14q22 or 14q24.3.

  8. Independent Yields of Kr and Xe Fragments in the Photofission of {sup 237}Np and {sup 243}Am Odd Nuclei

    SciTech Connect

    Gangrsky, Yu.P.; Zhemenik, V.I.; Mishinsky, G.V.; Penionzhkevich, Yu.E.

    2005-09-01

    Results are presented that were obtained by measuring the independent yields of Kr (A = 89 - 93) and Xe (A = 135 - 142) appearing as fragments in the photofission of {sup 237}Np and {sup 243}Am odd nuclei. The respective experiments were performed in a beam of bremsstrahlung photons from electrons accelerated to an energy of 25 MeV at the microtron of the Laboratory of Nuclear Reactions at the Joint Institute for Nuclear Research (JINR, Dubna). Use was made of the procedure involving the transportation of fragments emitted from the target by a gas flow along a capillary and the condensation of inert gases in a cryostat at liquid-nitrogen temperature. The identification of Kr and Xe appearing as fragments was performed by the gamma spectra of their daughter products. The mass-number distributions of the independent yields of Kr and Xe isotopes were obtained, along with those for the complementary fragments (Y and La in the fission of {sup 237}Np and Nb and Pr in the fission of {sup 243}Am)

  9. H I study of the environment around ESO 243-49, the host galaxy of an intermediate-mass black hole

    NASA Astrophysics Data System (ADS)

    Musaeva, A.; Koribalski, B. S.; Farrell, S. A.; Sadler, E. M.; Servillat, M.; Jurek, R.; Lenc, E.; Starling, R. L. C.; Webb, N. A.; Godet, O.; Combes, F.; Barret, D.

    2015-02-01

    The lenticular galaxy ESO 243-49 hosts the ultraluminous X-ray source HLX-1, the best candidate intermediate-mass black hole (IMBH) currently known. The environments of IMBHs remain unknown, however, the proposed candidates include the nuclei of dwarf galaxies or globular clusters. Evidence at optical wavelengths points at HLX-1 being the remnant of an accreted dwarf galaxy. Here we report the Australia Telescope Compact Array radio observations of H I emission in and around ESO 243-49 searching for signatures of a recent merger event. No H I line emission is detected in ESO 243-49 with a 5σ upper limit on the H I gas mass of a few 108 M⊙. A likely reason for this non-detection is the cluster environment depleting ESO 243-49's H I gas reservoir. The upper limit is consistent with an interpretation of HLX-1 as a dwarf satellite of ESO 243-49, however, more sensitive observations are required for a detection. We detect ˜5× 108 M⊙ of H I gas in the peculiar spiral galaxy AM 0108-462, located at a projected distance of ˜170 kpc from ESO 243-49. This amount of H I gas is ˜10 times less than in spiral galaxies with similar optical and near-infrared properties in the field, strengthening the conclusion that the cluster environment indeed depletes the H I gas reservoir of these two galaxies. Here we also report observations of AM 0108-462 in several optical and near-infrared bands using the Magellan 6.5-m telescopes, and archival X-ray and ultraviolet observations with XMM-Newton and Swift. These data combined with the H I line data suggest it is likely that AM 0108-462 is experiencing a merger event.

  10. Viscosity Measurements of Ethyl Fluoride (R161) from 243 K to 363 K at Pressures up to 30 MPa

    NASA Astrophysics Data System (ADS)

    Meng, Xianyang; Gu, Xiaoyun; Wu, Jiangtao; Bi, Shengshan

    2015-11-01

    The Montreal Protocol and its subsequent amendments have created a schedule to replace ozone depletion substances, such as chlorofluorocarbons and hydrochlorofluorocarbons, with chlorine-free molecules in several industrial applications. Ethyl fluoride (R161, C2H5F, 353-36-6) was found to be a potential alternative refrigerant for the replacement of controlled substances, such as R22 with excellent cycle performance. In this work, the viscosity of ethyl fluoride is reported at temperatures from 243 K to 363 K and at pressures from saturation pressure to 30 MPa. The experiment was performed with a calibrated vibrating-wire viscometer, which exhibited a combined expanded uncertainty of 2.5 % with a level of confidence of 0.95 (k = 2) for such a fluid. A scheme based on a hard-spheres model was used to correlate the experimental results. The average absolute deviation of the experimental results from the correlations for R161 is 0.88 %.

  11. Protective efficacy of P7C3-S243 in the 6-hydroxydopamine model of Parkinson’s disease

    PubMed Central

    De Jesús-Cortés, Héctor; Miller, Adam D; Britt, Jeremiah K; DeMarco, Anthony J; De Jesús-Cortés, Mayralis; Stuebing, Emily; Naidoo, Jacinth; Vázquez-Rosa, Edwin; Morlock, Lorraine; Williams, Noelle S; Ready, Joseph M; Narayanan, Nandakumar S; Pieper, Andrew A

    2016-01-01

    BACKGROUND There are currently no therapeutic options for patients with Parkinson’s disease that prevent or slow the death of dopaminergic neurons. We have recently identified the novel P7C3 class of neuroprotective molecules that blocks neuron cell death. AIMS The aim of this study was to determine whether treatment with highly active members of the P7C3 series blocks dopaminergic neuron cell death and associated behavioral and neurochemical deficits in the rat 6-hydroxydopamine (6-OHDA) model of Parkinson’s disease. METHODS After unilateral injection of 6-OHDA into the median forebrain bundle, rats were assessed for behavioral function in the open field, cylinder test, and amphetamine-induced circling test. Thereafter, their brains were subjected to neurochemical and immunohistochemical analysis of dopaminergic neuron survival. Analysis was conducted as a function of treatment with P7C3 compounds, with administration initiated either before or after 6-OHDA exposure. RESULTS Animals administered P7C3-A20 or P7C3-S243, two of the most advanced agents in the P7C3 series of neuroprotective compounds, both before and after 6-OHDA exposure showed evidence of protective efficacy in all measures. When P7C3-S243 administration was initiated after 6-OHDA exposure, rats also showed protective efficacy in all measures, which included blocking dopaminergic neuron cell death in ipsilateral substantia nigra pars compacta, preservation of dopamine and its metabolites in ipsilateral striatum, and preservation of normal motor behavior. CONCLUSIONS The P7C3 series of compounds may form the basis for developing new therapeutic agents for slowing or preventing progression of Parkinson’s disease. PMID:27158662

  12. A monolithic collapse origin for the thin and thick disc structure of the S0 galaxy ESO 243-49

    NASA Astrophysics Data System (ADS)

    Comerón, S.; Salo, H.; Peletier, R. F.; Mentz, J.

    2016-09-01

    ESO 243-49 is a high-mass (circular velocity vc ≈ 200 km s-1), edge-on S0 galaxy in the Abell 2877 cluster at a distance of ~95 Mpc. To elucidate the origin of the thick disc of this S0 galaxy, we use Multi Unit Spectroscopic Explorer (MUSE) science verification data to study its kinematics and stellar populations. The thick disc emits ~80% of the light at heights in excess of 3.5 arcsec (1.6 kpc). The rotation velocities of its stars lag by 30-40 km s-1 compared to those in the thin disc, which is compatible with the asymmetric drift. The thick disc is found to be more metal-poor than the thin disc, but both discs have old ages. We suggest an internal origin for the thick disc stars in high-mass galaxies. We propose that the thick disc formed either a) first in a turbulent phase with a high star formation rate and that a thin disc formed shortly afterwards, or b) because of the dynamical heating of a thin pre-existing component. Either way, the star formation in ESO 243-49 was quenched just a few Gyr after the galaxy was born and the formation of a thin and a thick disc must have occurred before the galaxy stopped forming stars. The formation of the discs was so fast that it could be described as a monolithic collapse where several generations of stars formed in rapid succession. Based on observations made at the European Southern Observatory using the Very Large Telescope under programme 60.A-9328(A).

  13. Exonic Re-Sequencing of the Chromosome 2q24.3 Parkinson’s Disease Locus

    PubMed Central

    Labbé, Catherine; Ogaki, Kotaro; Lorenzo-Betancor, Oswaldo; Carrasquillo, Minerva M.; Heckman, Michael G.; McCarthy, Allan; Soto-Ortolaza, Alexandra I.; Walton, Ronald L.; Lynch, Timothy; Siuda, Joanna; Opala, Grzegorz; Krygowska-Wajs, Anna; Barcikowska, Maria; Czyzewski, Krzysztof; Dickson, Dennis W.; Uitti, Ryan J.; Wszolek, Zbigniew K.; Ross, Owen A.

    2015-01-01

    Genome-wide association studies (GWAS) in Parkinson’s disease (PD) have identified over 20 genomic regions associated with disease risk. Many of these loci include several candidate genes making it difficult to pinpoint the causal gene. The locus on chromosome 2q24.3 encompasses three genes: B3GALT1, STK39, and CERS6. In order to identify if the causal variants are simple missense changes, we sequenced all 31 exons of these three genes in 187 patients with PD. We identified 13 exonic variants including four non-synonymous and three insertion/deletion variants (indels). These non-synonymous variants and rs2102808, the GWAS tag SNP, were genotyped in three independent series consisting of a total of 1976 patients and 1596 controls. Our results show that the seven identified 2q24.3 coding variants are not independently responsible for the GWAS association signal at the locus; however, there is a haplotype, which contains both rs2102808 and a STK39 exon 1 6bp indel variant, that is significantly associated with PD risk (Odds Ratio [OR] = 1.35, 95% CI: 1.11–1.64, P = 0.003). This haplotype is more associated than each of the two variants independently (OR = 1.23, P = 0.005 and 1.10, P = 0.10, respectively). Our findings suggest that the risk variant is likely located in a non-coding region. Additional sequencing of the locus including promoter and regulatory regions will be needed to pinpoint the association at this locus that leads to an increased risk to PD. PMID:26090850

  14. 30 CFR 243.7 - What must a person do when posting a bond or other surety instrument or demonstrating financial...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ....7 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT SUSPENSIONS PENDING APPEAL AND BONDING-MINERALS REVENUE MANAGEMENT General Provisions § 243.7 What...(a), or any other theory, as a defense if MMS calls your bond or requires you to pay based on...

  15. 25 CFR 243.12 - Are Alaska reindeer trust assets maintained by the U.S. Government for the benefit of Alaska...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Are Alaska reindeer trust assets maintained by the U.S..., DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.12 Are Alaska reindeer trust assets maintained by the U.S. Government for the benefit of Alaska Natives? Only the titles to Alaskan...

  16. 25 CFR 243.12 - Are Alaska reindeer trust assets maintained by the U.S. Government for the benefit of Alaska...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Are Alaska reindeer trust assets maintained by the U.S..., DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.12 Are Alaska reindeer trust assets maintained by the U.S. Government for the benefit of Alaska Natives? Only the titles to Alaskan...

  17. 25 CFR 243.12 - Are Alaska reindeer trust assets maintained by the U.S. Government for the benefit of Alaska...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Are Alaska reindeer trust assets maintained by the U.S..., DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.12 Are Alaska reindeer trust assets maintained by the U.S. Government for the benefit of Alaska Natives? Only the titles to Alaskan...

  18. 25 CFR 243.12 - Are Alaska reindeer trust assets maintained by the U.S. Government for the benefit of Alaska...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true Are Alaska reindeer trust assets maintained by the U.S..., DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.12 Are Alaska reindeer trust assets maintained by the U.S. Government for the benefit of Alaska Natives? Only the titles to Alaskan...

  19. 25 CFR 243.12 - Are Alaska reindeer trust assets maintained by the U.S. Government for the benefit of Alaska...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Are Alaska reindeer trust assets maintained by the U.S..., DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.12 Are Alaska reindeer trust assets maintained by the U.S. Government for the benefit of Alaska Natives? Only the titles to Alaskan...

  20. 30 CFR 243.6 - When must I or another person meet the bonding or financial solvency requirements under this part?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false When must I or another person meet the bonding... BONDING-MINERALS REVENUE MANAGEMENT General Provisions § 243.6 When must I or another person meet the bonding or financial solvency requirements under this part? If you must meet the bonding or...

  1. CAPN5 mutation in hereditary uveitis: the R243L mutation increases calpain catalytic activity and triggers intraocular inflammation in a mouse model.

    PubMed

    Wert, Katherine J; Bassuk, Alexander G; Wu, Wen-Hsuan; Gakhar, Lokesh; Coglan, Diana; Mahajan, MaryAnn; Wu, Shu; Yang, Jing; Lin, Chyuan-Sheng; Tsang, Stephen H; Mahajan, Vinit B

    2015-08-15

    A single amino acid mutation near the active site of the CAPN5 protease was linked to the inherited blinding disorder, autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV, OMIM #193235). In homology modeling with other calpains, this R243L CAPN5 mutation was situated in a mobile loop that gates substrate access to the calcium-regulated active site. In in vitro activity assays, the mutation increased calpain protease activity and made it far more active at low concentrations of calcium. To test whether the disease allele could yield an animal model of ADNIV, we created transgenic mice expressing human (h) CAPN5(R243L) only in the retina. The resulting hCAPN5(R243L) transgenic mice developed a phenotype consistent with human uveitis and ADNIV, at the clinical, histological and molecular levels. The fundus of hCAPN5(R243L) mice showed enhanced autofluorescence (AF) and pigment changes indicative of reactive retinal pigment epithelial cells and photoreceptor degeneration. Electroretinography showed mutant mouse eyes had a selective loss of the b-wave indicating an inner-retina signaling defect. Histological analysis of mutant mouse eyes showed protein extravasation from dilated vessels into the anterior chamber and vitreous, vitreous inflammation, vitreous and retinal fibrosis and retinal degeneration. Analysis of gene expression changes in the hCAPN5(R243L) mouse retina showed upregulation of several markers, including members of the Toll-like receptor pathway, chemokines and cytokines, indicative of both an innate and adaptive immune response. Since many forms of uveitis share phenotypic characteristics of ADNIV, this mouse offers a model with therapeutic testing utility for ADNIV and uveitis patients. PMID:25994508

  2. A novel maternally inherited 8q24.3 and a rare paternally inherited 14q23.3 CNVs in a family with neurodevelopmental disorders.

    PubMed

    Hu, Jie; Sathanoori, Malini; Kochmar, Sally; Azage, Meron; Mann, Susan; Madan-Khetarpal, Suneeta; Goldstein, Amy; Surti, Urvashi

    2015-08-01

    A 7-year-old female with developmental delay (DD), autism spectrum disorder (ASD), intellectual disability (ID), attention deficit hyperactivity disorder (ADHD), and seizures was referred to our laboratory for oligomicroarray analysis. The analysis revealed a 540 kb microdeletion in the chromosome 8q24.3 region (143,610,058-144,150,241) encompassing multiple genes. Two siblings of the proband were also analyzed. The proband's older sister with DD, seizures, and ASD has a 438 kb intragenic microdeletion of the GPHN gene in the chromosome 14q23.3 region (67,105,512-67,543,291) containing multiple exons, while the proband's older brother with DD, ASD, ID, and ADHD has both the 8q24.3 and the 14q23.3 deletions. All three siblings have a normal karyotype at the 650 G-band level of resolution. Parental FISH analysis indicates that the mother is a carrier for the 8q24.3 deletion and the father is a carrier for the 14q23.3 deletion. The 8q24.3 deletion seen in our patients has not been reported in the literature, while the small deletions of the 14q23.3 region involving multiple exons of the GPHN gene have been reported in a handful of patients in a recent study. The size of the 8q24.3 deletion and its genomic content, as well as the maternal family history, strongly suggest the association between the deletion and the neurodevelopmental disorders. Our study also provides more evidence in support of the association between GPHN deletion and neurodevelopmental disorders. PMID:25866352

  3. CAPN5 mutation in hereditary uveitis: the R243L mutation increases calpain catalytic activity and triggers intraocular inflammation in a mouse model

    PubMed Central

    Wert, Katherine J.; Bassuk, Alexander G.; Wu, Wen-Hsuan; Gakhar, Lokesh; Coglan, Diana; Mahajan, MaryAnn; Wu, Shu; Yang, Jing; Lin, Chyuan-Sheng; Tsang, Stephen H.; Mahajan, Vinit B.

    2015-01-01

    A single amino acid mutation near the active site of the CAPN5 protease was linked to the inherited blinding disorder, autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV, OMIM #193235). In homology modeling with other calpains, this R243L CAPN5 mutation was situated in a mobile loop that gates substrate access to the calcium-regulated active site. In in vitro activity assays, the mutation increased calpain protease activity and made it far more active at low concentrations of calcium. To test whether the disease allele could yield an animal model of ADNIV, we created transgenic mice expressing human (h) CAPN5R243L only in the retina. The resulting hCAPN5R243L transgenic mice developed a phenotype consistent with human uveitis and ADNIV, at the clinical, histological and molecular levels. The fundus of hCAPN5R243L mice showed enhanced autofluorescence (AF) and pigment changes indicative of reactive retinal pigment epithelial cells and photoreceptor degeneration. Electroretinography showed mutant mouse eyes had a selective loss of the b-wave indicating an inner-retina signaling defect. Histological analysis of mutant mouse eyes showed protein extravasation from dilated vessels into the anterior chamber and vitreous, vitreous inflammation, vitreous and retinal fibrosis and retinal degeneration. Analysis of gene expression changes in the hCAPN5R243L mouse retina showed upregulation of several markers, including members of the Toll-like receptor pathway, chemokines and cytokines, indicative of both an innate and adaptive immune response. Since many forms of uveitis share phenotypic characteristics of ADNIV, this mouse offers a model with therapeutic testing utility for ADNIV and uveitis patients. PMID:25994508

  4. Recoil-α-fission and recoil-α-α-fission events observed in the reaction 48Ca + 243Am

    NASA Astrophysics Data System (ADS)

    Forsberg, U.; Rudolph, D.; Andersson, L.-L.; Di Nitto, A.; Düllmann, Ch. E.; Fahlander, C.; Gates, J. M.; Golubev, P.; Gregorich, K. E.; Gross, C. J.; Herzberg, R.-D.; Heßberger, F. P.; Khuyagbaatar, J.; Kratz, J. V.; Rykaczewski, K.; Sarmiento, L. G.; Schädel, M.; Yakushev, A.; Åberg, S.; Ackermann, D.; Block, M.; Brand, H.; Carlsson, B. G.; Cox, D.; Derkx, X.; Dobaczewski, J.; Eberhardt, K.; Even, J.; Gerl, J.; Jäger, E.; Kindler, B.; Krier, J.; Kojouharov, I.; Kurz, N.; Lommel, B.; Mistry, A.; Mokry, C.; Nazarewicz, W.; Nitsche, H.; Omtvedt, J. P.; Papadakis, P.; Ragnarsson, I.; Runke, J.; Schaffner, H.; Schausten, B.; Shi, Yue; Thörle-Pospiech, P.; Torres, T.; Traut, T.; Trautmann, N.; Türler, A.; Ward, A.; Ward, D. E.; Wiehl, N.

    2016-09-01

    Products of the fusion-evaporation reaction 48Ca + 243Am were studied with the TASISpec set-up at the gas-filled separator TASCA at the GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany. Amongst the detected thirty correlated α-decay chains associated with the production of element Z = 115, two recoil-α-fission and five recoil- α- α-fission events were observed. The latter five chains are similar to four such events reported from experiments performed at the Dubna gas-filled separator, and three such events reported from an experiment at the Berkeley gas-filled separator. The four chains observed at the Dubna gas-filled separator were assigned to start from the 2n-evaporation channel 289115 due to the fact that these recoil- α- α-fission events were observed only at low excitation energies. Contrary to this interpretation, we suggest that some of these recoil- α- α-fission decay chains, as well as some of the recoil- α- α-fission and recoil-α-fission decay chains reported from Berkeley and in this article, start from the 3n-evaporation channel 288115.

  5. Physiological Roles for Two Periplasmic Nitrate Reductases in Rhodobacter sphaeroides 2.4.3 (ATCC 17025)▿

    PubMed Central

    Hartsock, Angela; Shapleigh, James P.

    2011-01-01

    The metabolically versatile purple bacterium Rhodobacter sphaeroides 2.4.3 is a denitrifier whose genome contains two periplasmic nitrate reductase-encoding gene clusters. This work demonstrates nonredundant physiological roles for these two enzymes. One cluster is expressed aerobically and repressed under low oxygen while the second is maximally expressed under low oxygen. Insertional inactivation of the aerobically expressed nitrate reductase eliminated aerobic nitrate reduction, but cells of this strain could still respire nitrate anaerobically. In contrast, when the anaerobic nitrate reductase was absent, aerobic nitrate reduction was detectable, but anaerobic nitrate reduction was impaired. The aerobic nitrate reductase was expressed but not utilized in liquid culture but was utilized during growth on solid medium. Growth on a variety of carbon sources, with the exception of malate, the most oxidized substrate used, resulted in nitrite production on solid medium. This is consistent with a role for the aerobic nitrate reductase in redox homeostasis. These results show that one of the nitrate reductases is specific for respiration and denitrification while the other likely plays a role in redox homeostasis during aerobic growth. PMID:21949073

  6. A large early-onset Alzheimer`s disease pedigree linked to chromosome 14q24.3

    SciTech Connect

    Hannequin, D.; Campion, D.; Brice, A.

    1994-09-01

    A large French pedigree including 34 subjects with early-onset progressive dementia was identified. In patients, the mean age-at-onset was 46 {plus_minus} 3.5 (SD) years and the mean age at death 52.6 {plus_minus} 5.7 (SD) years. No evidence for anticipation or genetic imprinting was found. Twelve patients were clinically diagnosed as probable Alzheimer`s disease (AD) according to the NINCDS-ADRDA criteria. Myoclonus and extrapyramidal signs were common and seizures were found in all affected subjects. At autopsy, neuropathological changes typical of AD were present in two brains. A significant lod score of 5.38 was observed at a recombination fraction of {theta} = 0.0 with the genetic marker D14S43, thereby establishing that the responsible gene was located on chromosome 14q24.3. Furthermore, no obligate recombinant was observed with markers D14S77 and D14S71. Typing other genetic markers in this region will allow us to localize more precisely the pathological gene.

  7. FIRST EVIDENCE FOR SPECTRAL STATE TRANSITIONS IN THE ESO 243-49 HYPERLUMINOUS X-RAY SOURCE HLX-1

    SciTech Connect

    Godet, O.; Barret, D.; Webb, N. A.; Farrell, S. A.; Gehrels, N.

    2009-11-10

    The brightest ultra-luminous X-ray source, ESO 243-49 HLX-1, with a 0.2-10 keV X-ray luminosity of up to 10{sup 42} erg s{sup -1}, provides the strongest evidence to date for the existence of intermediate mass black holes (BHs). Although small-scale X-ray spectral variability has already been demonstrated, we have initiated a monitoring campaign with the X-ray Telescope (XRT) onboard the Swift satellite to search for luminosity-related spectral changes and to compare its behavior with the better-studied stellar mass BHs. In this Letter, we report a drop in the XRT count rate by a factor of approx8 which occurred simultaneously with a hardening of the X-ray spectrum. A second observation found that the source had re-brightened by a factor of approx21 which occurred simultaneously with a softening of the X-ray spectrum. This may be the first evidence for a transition between the low/hard and high/soft states.

  8. Gender Difference in Prevalence of Signs and Symptoms of Temporomandibular Joint Disorders: A Retrospective Study on 243 Consecutive Patients

    PubMed Central

    Bagis, Bora; Ayaz, Elif Aydogan; Turgut, Sedanur; Durkan, Rukiye; Özcan, Mutlu

    2012-01-01

    Background: This study evaluated the prevalence of the signs and symptoms of temporomandibular joint disorder (TMD) among patients with TMD symptoms. Methods: Between September 2011 and December 2011, 243 consecutive patients (171 females, 72 males, mean age 41 years) who were referred to the Department of Prosthodontics, Faculty of Dentistry, Karadeniz Technical University, Trabzon were examined physically and completed a questionnaire regarding age, gender, social status, general health, antidepressant drug usage, dental status, limited mouth opening, temporomandibular joint (TMJ) sounds, and parafunctions (bruxism, clenching). The data were analyzed using the chi-square test and binary logistic regression model (alpha = 0.05). Results: With a frequency of 92%, pain in the temporal muscle was the most common symptom, followed by pain during mouth opening (89%) in both genders. TMJ pain at rest, pain in the masseter muscle, clicking, grinding, and anti-depressant use were significantly more frequent in females than males. Age (p=0.006; odds ratio 0.954; 95% CI 0.922-0.987) and missing teeth (p=0.003; odds ratio 3.753; 95% CI 1.589-8.863) had significant effects on the prevalence of TMD. Conclusion: Females had TMD signs and symptoms more frequently than males in the study population. The most common problem in both genders was pain. PMID:22991492

  9. Novel heterozygous C243Y A20/TNFAIP3 gene mutation is responsible for chronic inflammation in autosomal-dominant Behçet's disease

    PubMed Central

    Shigemura, Tomonari; Kaneko, Naoe; Kobayashi, Norimoto; Kobayashi, Keiko; Takeuchi, Yusuke; Nakano, Naoko; Masumoto, Junya; Agematsu, Kazunaga

    2016-01-01

    Objective Although Behçet's disease (BD) is a chronic inflammatory disorder of uncertain aetiology, the existence of familial BD with autosomal-dominant traits suggests that a responsibility gene (or genes) exists. We investigated a Japanese family with a history of BD to search for pathogenic mutations underlying the biological mechanisms of BD. Methods 6 patients over 4 generations who had suffered from frequent oral ulcers, genital ulcers and erythaema nodosum-like lesions in the skin were assessed. Whole-exome sequencing was performed on genomic DNA, and cytokine production was determined from stimulated mononuclear cells. Inflammatory cytokine secretion and Nod2-mediated NF-κB activation were analysed using the transfected cells. Results By whole-exome sequencing, we identified a common heterozygous missense mutation in A20/TNFAIP3, a gene known to regulate NF-κB signalling, for which all affected family members carried a heterozygous C243Y mutation in the ovarian tumour domain. Mononuclear cells obtained from the proband and his mother produced large amounts of interleukin 1β, IL-6 and tumour necrosis factor α (TNF-a) on stimulation as compared with those from normal controls. Although inflammatory cytokine secretion was suppressed by wild-type transfected cells, it was suppressed to a much lesser extent by mutated C243Y A20/TNFAIP3-transfected cells. In addition, impaired suppression of Nod2-mediated NF-κB activation by C243Y A20/TNFAIP3 was observed. Conclusions A C243Y mutation in A20/TNFAIP3 was likely responsible for increased production of human inflammatory cytokines by reduced suppression of NF-κB activation, and may have accounted for the autosomal-dominant Mendelian mode of BD transmission in this family. PMID:27175295

  10. Molecular cloning of t(2;7)(p24.3;p14.2), a novel chromosomal translocation in myelodysplastic syndrome-derived acute myeloid leukemia.

    PubMed

    Fujita, Kazuhiro; Sanada, Masashi; Harada, Hiroshi; Mori, Hiraku; Niikura, Haruo; Omine, Mitsuhiro; Inazawa, Johji; Imoto, Issei

    2009-06-01

    In this study, we report the molecular structure of the breakpoint region in a new chromosomal translocation, t(2;7)(p24.3;p14.2), in a case of acute myeloid leukemia transformed from myelodysplastic syndrome (MDS). An extensive fluorescence in situ hybridization (FISH) analysis showed that NAG (2p24.3) and ELMO1 (7p14.2) were involved at the breakpoints of t(2;7)(p24.3;p14.2). Furthermore, we detected a novel chimeric transcript consisting of NAG and ELMO1. Interestingly, this transcript encoded a truncated molecular form of 3'ELMO1 as the result of a frameshift caused by the chromosomal translocation. Although this study does not provide direct evidence that a defect in NAG-ELMO1 plays a role in the pathogenesis or the leukemic change in MDS, it does suggest that defects in NAG-ELMO1 potentially contributed to the leukemic progression in this case. PMID:19407829

  11. THE COOL ACCRETION DISK IN ESO 243-49 HLX-1: FURTHER EVIDENCE OF AN INTERMEDIATE-MASS BLACK HOLE

    SciTech Connect

    Davis, Shane W.; Narayan, Ramesh; Zhu Yucong; Servillat, Mathieu; Barret, Didier; Godet, Olivier; Webb, Natalie A.; Farrell, Sean A.

    2011-06-20

    With an inferred bolometric luminosity exceeding 10{sup 42} erg s{sup -1}, HLX-1 in ESO 243-49 is the most luminous of ultraluminous X-ray sources and provides one of the strongest cases for the existence of intermediate-mass black holes. We obtain good fits to disk-dominated observations of the source with BHSPEC, a fully relativistic black hole accretion disk spectral model. Due to degeneracies in the model arising from the lack of independent constraints on inclination and black hole spin, there is a factor of 100 uncertainty in the best-fit black hole mass M. Nevertheless, spectral fitting of XMM-Newton observations provides robust lower and upper limits with 3000 M{sub sun} {approx}< M {approx}< 3 x 10{sup 5} M{sub sun}, at 90% confidence, placing HLX-1 firmly in the intermediate-mass regime. The lower bound on M is entirely determined by matching the shape and peak energy of the thermal component in the spectrum. This bound is consistent with (but independent of) arguments based solely on the Eddington limit. Joint spectral modeling of the XMM-Newton data with more luminous Swift and Chandra observations increases the lower bound to 6000 M{sub sun}, but this tighter constraint is not independent of the Eddington limit. The upper bound on M is sensitive to the maximum allowed inclination i, and is reduced to M {approx}< 10{sup 5} M{sub sun} if we limit i {approx}< 75{sup 0}.

  12. Ceftaroline versus isolates from animal bite wounds: comparative in vitro activities against 243 isolates, including 156 Pasteurella species isolates.

    PubMed

    Goldstein, Ellie J C; Citron, Diane M; Merriam, C Vreni; Tyrrell, Kerin L

    2012-12-01

    More than 5 million Americans are bitten by animals, usually dogs, annually. Bite patients comprise ∼1% of all patients who visit emergency departments (300,000/year), and approximately 10,000 require hospitalization and intravenous antibiotics. Ceftaroline is the bioactive component of the prodrug ceftaroline fosamil, which is FDA approved for the treatment of acute bacterial skin and skin structure infections (ABSSSIs), including those containing methicillin-resistant Staphylococcus aureus (MRSA). There are no in vitro data about the activity of ceftaroline against Pasteurella multocida subsp. multocida and Pasteurella multocida subsp. septica, other Pasteurella spp., or other bite wound isolates. We therefore studied the in vitro activity of ceftaroline against 243 animal bite isolates. MICs were determined using the broth microdilution method according to CLSI guidelines. Comparator drugs included cefazolin, ceftriaxone, ertapenem, ampicillin-sulbactam, azithromycin, doxycycline, and sulfamethoxazole-trimethoprim (SMX-TMP). Ceftaroline was the most active agent against all 5 Pasteurella species, including P. multocida subsp. multocida and P. multocida subsp. septica, with a maximum MIC of ≤0.008 μg/ml; more active than ceftriaxone and ertapenem (MIC(90)s, ≤0.015 μg/ml); and more active than cefazolin (MIC(90), 0.5 μg/ml) doxycycline (MIC(90), 0.125 μg/ml), azithromycin (MIC(90), 0.5 μg/ml), ampicillin-sulbactam (MIC(90), 0.125 μg/ml), and SMX-TMP (MIC(90), 0.125 μg/ml). Ceftaroline was also very active against all S. aureus isolates (MIC(90), 0.125 μg/ml) and other Staphylococcus and Streptococcus species, with a maximum MIC of 0.125 μg/ml against all bite isolates tested. Ceftaroline has potential clinical utility against infections involving P. multocida, other Pasteurella species, and aerobic Gram-positive isolates, including S. aureus. PMID:23027193

  13. Ceftaroline versus Isolates from Animal Bite Wounds: Comparative In Vitro Activities against 243 Isolates, Including 156 Pasteurella Species Isolates

    PubMed Central

    Citron, Diane M.; Merriam, C. Vreni; Tyrrell, Kerin L.

    2012-01-01

    More than 5 million Americans are bitten by animals, usually dogs, annually. Bite patients comprise ∼1% of all patients who visit emergency departments (300,000/year), and approximately 10,000 require hospitalization and intravenous antibiotics. Ceftaroline is the bioactive component of the prodrug ceftaroline fosamil, which is FDA approved for the treatment of acute bacterial skin and skin structure infections (ABSSSIs), including those containing methicillin-resistant Staphylococcus aureus (MRSA). There are no in vitro data about the activity of ceftaroline against Pasteurella multocida subsp. multocida and Pasteurella multocida subsp. septica, other Pasteurella spp., or other bite wound isolates. We therefore studied the in vitro activity of ceftaroline against 243 animal bite isolates. MICs were determined using the broth microdilution method according to CLSI guidelines. Comparator drugs included cefazolin, ceftriaxone, ertapenem, ampicillin-sulbactam, azithromycin, doxycycline, and sulfamethoxazole-trimethoprim (SMX-TMP). Ceftaroline was the most active agent against all 5 Pasteurella species, including P. multocida subsp. multocida and P. multocida subsp. septica, with a maximum MIC of ≤0.008 μg/ml; more active than ceftriaxone and ertapenem (MIC90s, ≤0.015 μg/ml); and more active than cefazolin (MIC90, 0.5 μg/ml) doxycycline (MIC90, 0.125 μg/ml), azithromycin (MIC90, 0.5 μg/ml), ampicillin-sulbactam (MIC90, 0.125 μg/ml), and SMX-TMP (MIC90, 0.125 μg/ml). Ceftaroline was also very active against all S. aureus isolates (MIC90, 0.125 μg/ml) and other Staphylococcus and Streptococcus species, with a maximum MIC of 0.125 μg/ml against all bite isolates tested. Ceftaroline has potential clinical utility against infections involving P. multocida, other Pasteurella species, and aerobic Gram-positive isolates, including S. aureus. PMID:23027193

  14. Apparent histological changes of adipocytes after treatment with CL 316,243, a β-3-adrenergic receptor agonist

    PubMed Central

    Ghorbani, Masoud; Teimourian, Shahram; Farzad, Reza; Asl, Nabiollah Namvar

    2015-01-01

    Background and objectives The objective of this experiment was to study the effect of CL 316,243 (CL) (a highly selective β3-adrenergic receptor agonist) on cellular changes occurring in retroperitoneal white adipose tissue (RWAT) of lean and obese rats. Methods Ten-month-old lean and obese Zucker rats were implanted subcutaneously with osmotic mini-pumps, infusing either saline or CL (1 mg/kg body weight/day) for 4 weeks. Results There was no effect of CL on food intake. However, the resting metabolic rate in lean and obese rats increased by 55% and 96% per rat, respectively. Total RWAT weight decreased in both lean and obese rats under influence of CL treatment by 65% and 38%, respectively. Total body weight and body fat were lower in CL treated rats. Detection of uncoupling protein 1 (UCP1) in RWAT was confirmed qualitatively by both immunohistochemistry and immunofluorescence using a rabbit anti rat UCP1 antibody which showed the appearance of a marked increase of this protein in the adipose tissue. Stained semi-thin sections (0.5 μm) also demonstrated abundant nuclei in multilocular adipocytes, in endothelial cells associated with the vasculature, and in interstitial cells. In CL-treated obese rats, a clustering of several multilocular cells around the periphery of a white adipocyte was seen. Conclusion These results indicate that treatment of both lean and obese Zucker rats with CL induces extensive remodeling of RWAT that includes shrinkage of white adipose tissue, appearance of abundant multilocular cells in RWAT together with the appearance of a marked increase of UCP, preferentially in lean rats. PMID:25709398

  15. 16 CFR 24.3 - Misuse of the terms “waterproof,” “dustproof,” “warpproof,” “scuffproof,” “scratchproof,” “scuff...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... SELECT LEATHER AND IMITATION LEATHER PRODUCTS § 24.3 Misuse of the terms “waterproof,” “dustproof... deceptive to: (a) Use the term “Waterproof” to describe all or part of an industry product unless...

  16. 16 CFR 24.3 - Misuse of the terms “waterproof,” “dustproof,” “warpproof,” “scuffproof,” “scratchproof,” “scuff...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... SELECT LEATHER AND IMITATION LEATHER PRODUCTS § 24.3 Misuse of the terms “waterproof,” “dustproof... deceptive to: (a) Use the term “Waterproof” to describe all or part of an industry product unless...

  17. 16 CFR 24.3 - Misuse of the terms “waterproof,” “dustproof,” “warpproof,” “scuffproof,” “scratchproof,” “scuff...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... SELECT LEATHER AND IMITATION LEATHER PRODUCTS § 24.3 Misuse of the terms “waterproof,” “dustproof... deceptive to: (a) Use the term “Waterproof” to describe all or part of an industry product unless...

  18. 16 CFR 24.3 - Misuse of the terms “waterproof,” “dustproof,” “warpproof,” “scuffproof,” “scratchproof,” “scuff...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... SELECT LEATHER AND IMITATION LEATHER PRODUCTS § 24.3 Misuse of the terms “waterproof,” “dustproof... deceptive to: (a) Use the term “Waterproof” to describe all or part of an industry product unless...

  19. 16 CFR 24.3 - Misuse of the terms “waterproof,” “dustproof,” “warpproof,” “scuffproof,” “scratchproof,” “scuff...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... SELECT LEATHER AND IMITATION LEATHER PRODUCTS § 24.3 Misuse of the terms “waterproof,” “dustproof... deceptive to: (a) Use the term “Waterproof” to describe all or part of an industry product unless...

  20. X-RAY VARIABILITY AND HARDNESS OF ESO 243-49 HLX-1: CLEAR EVIDENCE FOR SPECTRAL STATE TRANSITIONS

    SciTech Connect

    Servillat, Mathieu; Farrell, Sean A.; Lin Dacheng; Godet, Olivier; Barret, Didier; Webb, Natalie A.

    2011-12-10

    The ultraluminous X-ray (ULX) source ESO 243-49 HLX-1, which reaches a maximum luminosity of 10{sup 42} erg s{sup -1} (0.2-10 keV), currently provides the strongest evidence for the existence of intermediate-mass black holes (IMBHs). To study the spectral variability of the source, we conduct an ongoing monitoring campaign with the Swift X-ray Telescope (XRT), which now spans more than two years. We found that HLX-1 showed two fast rise and exponential decay type outbursts in the Swift XRT light curve with increases in the count rate of a factor {approx}40 separated by 375 {+-} 13 days. We obtained new XMM-Newton and Chandra dedicated pointings that were triggered at the lowest and highest luminosities, respectively. From spectral fitting, the unabsorbed luminosities ranged from 1.9 Multiplication-Sign 10{sup 40} to 1.25 Multiplication-Sign 10{sup 42} erg s{sup -1}. We confirm here the detection of spectral state transitions from HLX-1 reminiscent of Galactic black hole binaries (GBHBs): at high luminosities, the X-ray spectrum showed a thermal state dominated by a disk component with temperatures of 0.26 keV at most, and at low luminosities the spectrum is dominated by a hard power law with a photon index in the range 1.4-2.1, consistent with a hard state. The source was also observed in a state consistent with the steep power-law state, with a photon index of {approx}3.5. In the thermal state, the luminosity of the disk component appears to scale with the fourth power of the inner disk temperature, which supports the presence of an optically thick, geometrically thin accretion disk. The low fractional variability (rms of 9% {+-} 9%) in this state also suggests the presence of a dominant disk. The spectral changes and long-term variability of the source cannot be explained by variations of the beaming angle and are not consistent with the source being in a super-Eddington accretion state as is proposed for most ULX sources with lower luminosities. All this

  1. Discovery of very high energy γ-ray emission from the BL Lacertae object PKS 0301-243 with H.E.S.S.

    NASA Astrophysics Data System (ADS)

    H.E.S.S. Collaboration; Abramowski, A.; Acero, F.; Aharonian, F.; Ait Benkhali, F.; Akhperjanian, A. G.; Angüner, E.; Anton, G.; Balenderan, S.; Balzer, A.; Barnacka, A.; Becherini, Y.; Becker Tjus, J.; Bernlöhr, K.; Birsin, E.; Bissaldi, E.; Biteau, J.; Böttcher, M.; Boisson, C.; Bolmont, J.; Bordas, P.; Brucker, J.; Brun, F.; Brun, P.; Bulik, T.; Carrigan, S.; Casanova, S.; Cerruti, M.; Chadwick, P. M.; Chalme-Calvet, R.; Chaves, R. C. G.; Cheesebrough, A.; Chrétien, M.; Colafrancesco, S.; Cologna, G.; Conrad, J.; Couturier, C.; Dalton, M.; Daniel, M. K.; Davids, I. D.; Degrange, B.; Deil, C.; deWilt, P.; Dickinson, H. J.; Djannati-Ataï, A.; Domainko, W.; Drury, L. O'C.; Dubus, G.; Dutson, K.; Dyks, J.; Dyrda, M.; Edwards, T.; Egberts, K.; Eger, P.; Espigat, P.; Farnier, C.; Fegan, S.; Feinstein, F.; Fernandes, M. V.; Fernandez, D.; Fiasson, A.; Fontaine, G.; Förster, A.; Füßling, M.; Gajdus, M.; Gallant, Y. A.; Garrigoux, T.; Giebels, B.; Glicenstein, J. F.; Grondin, M.-H.; Grudzińska, M.; Häffner, S.; Hague, J. D.; Hahn, J.; Harris, J.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hervet, O.; Hillert, A.; Hinton, J. A.; Hofmann, W.; Hofverberg, P.; Holler, M.; Horns, D.; Jacholkowska, A.; Jahn, C.; Jamrozy, M.; Janiak, M.; Jankowsky, F.; Jung, I.; Kastendieck, M. A.; Katarzyński, K.; Katz, U.; Kaufmann, S.; Khélifi, B.; Kieffer, M.; Klepser, S.; Klochkov, D.; Kluźniak, W.; Kneiske, T.; Kolitzus, D.; Komin, Nu.; Kosack, K.; Krakau, S.; Krayzel, F.; Krüger, P. P.; Laffon, H.; Lamanna, G.; Lefaucheur, J.; Lemoine-Goumard, M.; Lenain, J.-P.; Lennarz, D.; Lohse, T.; Lopatin, A.; Lu, C.-C.; Marandon, V.; Marcowith, A.; Marx, R.; Maurin, G.; Maxted, N.; Mayer, M.; McComb, T. J. L.; Medina, M. C.; Méhault, J.; Menzler, U.; Meyer, M.; Moderski, R.; Mohamed, M.; Moulin, E.; Murach, T.; Naumann, C. L.; de Naurois, M.; Nedbal, D.; Niemiec, J.; Nolan, S. J.; Oakes, L.; Ohm, S.; de Oña Wilhelmi, E.; Opitz, B.; Ostrowski, M.; Oya, I.; Panter, M.; Parsons, R. D.; Paz Arribas, M.; Pekeur, N. W.; Pelletier, G.; Perez, J.; Petrucci, P.-O.; Peyaud, B.; Pita, S.; Poon, H.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raab, S.; Raue, M.; Reimer, A.; Reimer, O.; Renaud, M.; de los Reyes, R.; Rieger, F.; Rob, L.; Rosier-Lees, S.; Rowell, G.; Rudak, B.; Rulten, C. B.; Sahakian, V.; Sanchez, D. A.; Santangelo, A.; Schlickeiser, R.; Schüssler, F.; Schulz, A.; Schwanke, U.; Schwarzburg, S.; Schwemmer, S.; Sol, H.; Spengler, G.; Spies, F.; Stawarz, Ł.; Steenkamp, R.; Stegmann, C.; Stinzing, F.; Stycz, K.; Sushch, I.; Szostek, A.; Tavernet, J.-P.; Terrier, R.; Tluczykont, M.; Trichard, C.; Valerius, K.; van Eldik, C.; Vasileiadis, G.; Venter, C.; Viana, A.; Vincent, P.; Völk, H. J.; Volpe, F.; Vorster, M.; Wagner, S. J.; Wagner, P.; Ward, M.; Weidinger, M.; Weitzel, Q.; White, R.; Wierzcholska, A.; Willmann, P.; Wörnlein, A.; Wouters, D.; Zacharias, M.; Zajczyk, A.; Zdziarski, A. A.; Zech, A.; Zechlin, H.-S.

    2013-11-01

    The active galactic nucleus PKS 0301-243 (z = 0.266) is a high-synchrotron-peaked BL Lac object that is detected at high energies (HE, 100 MeV 243 at very high energies (E > 100 GeV) by the High Energy Stereoscopic System (H.E.S.S.) from observations between September 2009 and December 2011 for a total live time of 34.9 h. Gamma rays above 200 GeV are detected at a significance of 9.4σ. A hint of variability at the 2.5σ level is found. An integral flux I(E > 200 GeV) = (3.3 ± 1.1stat ± 0.7syst) × 10-12 ph cm-2 s-1 and a photon index Γ = 4.6 ± 0.7stat ± 0.2syst are measured. Multi-wavelength light curves in HE, X-ray and optical bands show strong variability, and a minimal variability timescale of eight days is estimated from the optical light curve. A single-zone leptonic synchrotron self-Compton scenario satisfactorily reproduces the multi-wavelength data. In this model, the emitting region is out of equipartition and the jet is particle dominated. Because of its high redshift compared to other sources observed at TeV energies, the very high energy emission from PKS 0301-243 is attenuated by the extragalactic background light (EBL) and the measured spectrum is used to derive an upper limit on the opacity of the EBL.

  2. Remaining Sites Verification Package for the 600-243 Petroleum-Contaminated Soil Bioremediation Pad, Waste Site Reclassification Form 2007-033

    SciTech Connect

    J. M. Capron

    2008-11-07

    The 600-243 waste site consisted of a bioremediation pad for petroleum-contaminated soils resulting from the 1100 Area Underground Storage Tank (UST) upgrades in 1994. In accordance with this evaluation, the verification sampling results support a reclassification of this site to Interim Closed Out. The results of verification sampling show that residual contaminant concentrations do not preclude any future uses and allow for unrestricted use of shallow zone soils. The results also demonstrate that residual contaminant concentrations are protective of groundwater and the Columbia River.

  3. 241Am and 243Am charge distributions from muonic x-ray spectroscopy and the quadrupole moment of the 240Am fission isomer

    NASA Astrophysics Data System (ADS)

    Johnson, M. W.; Shera, E. B.; Hoehn, M. V.; Naumann, R. A.; Zumbro, J. D.; Bemis, C. E.

    1985-10-01

    The muonic K, L, and M X-ray spectra from 241Am and 243Am have been investigated. Analysis of these spectra yields intrinsic nuclear quadrupole moments [Q0241 = 12.16(15) e b and Q0243 = 12.10(17) e b] and Barrett radii. By combining these results with those from a previous optical isotope-shift study, the intrinsic quadrupole moment for the fission isomer 240fAm is deduced [Q0240f = 29.0(1.3) e b].

  4. Unique de novo interstitial deletion of chromosome 17, del(17) (q23.2q24.3) in a female newborn with multiple congenital anomalies

    SciTech Connect

    Levin, M.L.; Shaffer, L.G.; Lewis, R.L.

    1995-01-02

    We describe a newborn with a novel interstitial deletion of the long arm of chromosome 17 (del(17) (q23.2q24.3)) who died on day of life 17 during a recurrent apneic episode. Her phenotype included severe growth retardation, multiple facial anomalies, maldeveloped oralpharyngeal structures, and digital and widespread skeletal anomalies. This patient`s phenotype was compared to two other reported patients with deletion 17q with minor clinical overlap consistent with a unique deletion. 9 refs., 2 figs.

  5. De novo 14q24.2q24.3 microdeletion including IFT43 is associated with intellectual disability, skeletal anomalies, cardiac anomalies, and myopia.

    PubMed

    Stokman, Marijn F; Oud, Machteld M; van Binsbergen, Ellen; Slaats, Gisela G; Nicolaou, Nayia; Renkema, Kirsten Y; Nijman, Isaac J; Roepman, Ronald; Giles, Rachel H; Arts, Heleen H; Knoers, Nine V A M; van Haelst, Mieke M

    2016-06-01

    We report an 11-year-old girl with mild intellectual disability, skeletal anomalies, congenital heart defect, myopia, and facial dysmorphisms including an extra incisor, cup-shaped ears, and a preauricular skin tag. Array comparative genomic hybridization analysis identified a de novo 4.5-Mb microdeletion on chromosome 14q24.2q24.3. The deleted region and phenotype partially overlap with previously reported patients. Here, we provide an overview of the literature on 14q24 microdeletions and further delineate the associated phenotype. We performed exome sequencing to examine other causes for the phenotype and queried genes present in the 14q24.2q24.3 microdeletion that are associated with recessive disease for variants in the non-deleted allele. The deleted region contains 65 protein-coding genes, including the ciliary gene IFT43. Although Sanger and exome sequencing did not identify variants in the second IFT43 allele or in other IFT complex A-protein-encoding genes, immunocytochemistry showed increased accumulation of IFT-B proteins at the ciliary tip in patient-derived fibroblasts compared to control cells, demonstrating defective retrograde ciliary transport. This could suggest a ciliary defect in the pathogenesis of this disorder. © 2016 Wiley Periodicals, Inc. PMID:26892345

  6. Refined-mapping of the novel TSG within the 17q24.3 chromosomal region in non-small cell lung cancer samples

    PubMed Central

    Huang, Wayren; Wang, Yiching; Chu, Woeichyn; Tseng, Ruochia

    2016-01-01

    Lung cancer is a leading cause of cancer mortality in Taiwan. It has been previously demonstrated that alterations to tumor suppressor genes (TSGs) are involved in the multi-step carcinogenesis process that results in the development of human cancer, including lung cancer. Both copies of the TSG must be inactivated for their function to be lost. As a result, it is important to search for the genomic regions that potentially contain TSGs and to investigate the etiological association of lung cancer with the allelic deletion of various candidate TSGs. Previous genome-wide loss of heterozygosity (LOH) data has demonstrated that the chromosome region at 17q24.3 was a novel and frequent LOH region that was associated with non-small-cell lung cancer (NSCLC). In the present study, refined mapping using 9 additional microsatellite markers was performed targeting chromosome 17q24.3 by polymerase chain reaction (PCR)-LOH analysis. The allelic loss pattern across 48 available tumors indicates that the minimal deletion region was located between markers D17S1882 and D17S2193 and spanned a distance of approximately 2.7 Mb, reaching 65% LOH at locus D17S1816. A putative gene, LOC51321 (AMZ2), was postulated to be the deletion target on 17q24.3 based on the findings from these NSCLC samples. Reverse transcription-PCR (RT-PCR) expression analysis indicated reduced expression of LOC51321 in 54% (7/13) of the NSCLC cell lines tested and 36% (19/53) of the NSCLC tumor tissue samples analyzed. In CL1-5-F4 cells, low mRNA and protein expression of LOC51321 were associated with the promoter hypermethylation, as determined by RT-PCR, western blotting and methylation-specific PCR assays. In addition, treatment with 5-Aza-deoxycytosine successfully restored mRNA expression by de-methylating the putative promoter region in CL1-5-F4 cells that lacked LOC51321 expression, but did harbor the relevant methylated promoter. These findings indicate that LOC51321 may be involved in lung

  7. Densities of mixtures of heptane + methyl 1,1-dimethylethyl ether at temperatures between 243.16 and 333.14 K

    SciTech Connect

    Pinnick, H.R. Jr.; Falling, C.L.; Allred, G.C.; Parrish, W.R.

    1995-07-01

    With government mandates for including oxygenates (alcohols or ethers) in motor fuels, there is a need to develop accurate density tables for custody transfer purposes. This paper reports densities and excess volumes of binary mixtures of heptane and methyl 1,1-dimethylethyl ether (methyl tert-butyl ether, MTBE) at 243.16, 278.15, 288.17, 293,10, 313.14, and 333.14 K. Data were obtained at 0.34, 1.72, and 4.83 MPa. Mixture compositions were between 5 and 95 mol %. Equimolar excess volumes are about 0.4 cm{sup 3}/mol and are weak functions of temperature and pressure.

  8. The equilibrium constant for N2O5 = NO2 + NO3 - Absolute determination by direct measurement from 243 to 397 K

    NASA Technical Reports Server (NTRS)

    Cantrell, C. A.; Davidson, J. A.; Mcdaniel, A. H.; Shetter, R. E.; Calvert, J. G.

    1988-01-01

    Direct determinations of the equilibrium constant for the reaction N2O5 = NO2 + NO3 were carried out by measuring NO2, NO3, and N2O5 using long-path visible and infrared absorption spectroscopy as a function of temperature from 243 to 397 K. The first-order decay rate constant of N2O5 was experimentally measured as a function of temperature. These results are in turn used to derive a value for the rate coefficient for the NO-forming channel in the reaction of NO3 with NO2. The implications of the results for atmospheric chemistry, the thermodynamics of NO3, and for laboratory kinetics studies are discussed.

  9. Standardization of (166m)Ho and 243Am/239Np by live-timed anti-coincidence counting with extending dead time.

    PubMed

    da Silva, C J; Loureiro, J S; Delgado, J U; Poledna, R; Moreira, D S; Iwahara, A; Tauhata, L; da Silva, R L; Lopes, R T

    2012-09-01

    The National Laboratory for Metrology of Ionizing Radiation (LNMRI)/Brazil acquired (166m)Ho and (243)Am/(239)Np solutions from commercial suppliers in order to realize primary standardization and therefore reducing the associated uncertainties. The method used in the standardization was the live-timed 4πβ(LS)-γ(ΝaI(Tl)) anticoincidence counting. The live-timed anticoincidence system is operated since 2006 in LNMRI and is composed of two MTR2 modules donated by Laboratoire National Henri Becquerel (LNE-LNHB)/France. The data acquisition system uses a homemade LabView program and an Excel file for calculus. These systems have been used for primary standardization at LNMRI for many radionuclides and recently took part in the (124)Sb and (177)Lu International Key Comparisons with good performance. PMID:22417696

  10. Study of the Beta-delayed multiple particle break-up of the 2.43 MeV state in Be-9

    NASA Astrophysics Data System (ADS)

    Madurga Flores, Miguel; Borge, M. J. G.; Fynbo, H. O. U.; Jonson, B.; Nyman, G.; Prezado, Y.; Riisager, K.

    The aim of this work is to study the β -delayed multiparticle break-up of the 5/2- state in 9 Be at 2.43 MeV excitation energy. This process is relevant as it has been proposed recently that this level plays a role in the α(αn,γ)9 Be reaction. This state breaks-up in 2α+n, and sequential as well as direct ("democratic") decay have previously been considered. In our work energy and direction of the two emitted α particles has been measured, while those of the neutron have been reconstructed. The sequential decay is considered using the R-matrix formalism. For the democratic decay the hyper-spherical harmonics functions are used. The different decay processes are compared with the data using the Monte-Carlo method. Our preliminary results indicate that the data is better described when democratic decay is assumed.

  11. Integrative functional genomics identifies an enhancer looping to the SOX9 gene disrupted by the 17q24.3 prostate cancer risk locus

    PubMed Central

    Zhang, Xiaoyang; Cowper-Sal·lari, Richard; Bailey, Swneke D.; Moore, Jason H.; Lupien, Mathieu

    2012-01-01

    Genome-wide association studies (GWAS) are identifying genetic predisposition to various diseases. The 17q24.3 locus harbors the single nucleotide polymorphism (SNP) rs1859962 that is statistically associated with prostate cancer (PCa). It defines a 130-kb linkage disequilibrium (LD) block that lies in an ∼2-Mb gene desert area. The functional biology driving the risk associated with this LD block is unknown. Here, we integrate genome-wide chromatin landscape data sets, namely, epigenomes and chromatin openness from diverse cell types. This identifies a PCa-specific enhancer within the rs1859962 risk LD block that establishes a 1-Mb chromatin loop with the SOX9 gene. The rs8072254 and rs1859961 SNPs mapping to this enhancer impose allele-specific gene expression. The variant allele of rs8072254 facilitates androgen receptor (AR) binding driving increased enhancer activity. The variant allele of rs1859961 decreases FOXA1 binding while increasing AP-1 binding. The latter is key to imposing allele-specific gene expression. The rs8072254 variant in strong LD with the rs1859962 risk SNP can account for the risk associated with this locus, while rs1859961 is a rare variant less likely to contribute to the risk associated with this LD block. Together, our results demonstrate that multiple genetic variants mapping to a unique enhancer looping to the SOX9 oncogene can account for the risk associated with the PCa 17q24.3 locus. Allele-specific recruitment of the transcription factors androgen receptor (AR) and activating protein-1 (AP-1) account for the increased enhancer activity ascribed to this PCa-risk LD block. This further supports the notion that an integrative genomics approach can identify the functional biology disrupted by genetic risk variants. PMID:22665440

  12. Effect of Lactobacillus plantarum CJLP243 on the growth performance and cytokine response of weaning pigs challenged with enterotoxigenic Escherichia coli.

    PubMed

    Lee, J S; Awji, E G; Lee, S J; Tassew, D D; Park, Y B; Park, K S; Kim, M K; Kim, B; Park, S C

    2012-11-01

    The purpose of the present study was to evaluate the effect of diets containing Lactobacillus plantarum CJLP243 on the growth and cytokine response of weaning pigs (Sus scrofa) challenged with enterotoxigenic Escherichia coli (ETEC). In a 28-d experiment (14 d before and 14 d after challenge), a total of 108 pigs at 20 ± 1 d of age were allotted to 1 of 6 diets. These were a control diet without ETEC challenge (CON) and 5 treatment diets with ETEC challenge, including a control diet with ETEC challenge (negative control, NC); a positive control diet containing antibiotics (PC); control diet plus (10(8), 10(9), or 10(10)) cfu/kg L. plantarum CJLP243 (T1, T2, and T3, respectively). After challenge, NC showed the least ADFI, whereas PC and T3 had the greatest ADFI (P = 0.002). The ADG of PC, T2, and T3 were greater (P = 0.001) than that of CON, NC, and T1 during wk 1 to wk 2. During wk 3 to wk 4, a marked decline was seen in NC (P = 0.001) compared with CON, whereas PC and T3 showed increased ADG (P = 0.001). The overall ADG of PC and T3 were greater (P < 0.001) than the remaining groups. The PC and T3 had the greatest G:F during the second 2 wk (P = 0.002), and the overall 4-wk experimental period (P = 0.003). At 3 h after challenge, all groups except CON had greater rectal temperatures (RT; P < 0.05). The RT decreased to prechallenge temperatures at 9 h (PC and T3), 24 h (T1 and T2), and remained increased until d 7 in NC. At 7 and 14 d postinfection, the number of animals detected positive for ETEC by PCR assay was the greatest in NC; however, the PC group had the fewest ETEC-positive animals (P < 0.05), which was similar to T3. All challenged pigs, except T2, had greater concentrations of serum haptoglobin compared with CON, with the greatest concentration observed in NC (P < 0.001). Challenged pigs had increased serum concentrations of tumor necrosis factor alpha (TNF-α) 3 to 48 h postinfection, with the greatest concentration of TNF-α at 48 h observed in NC

  13. Human glutamate pyruvate transaminase (GPT): Localization to 8q24.3, cDNA and genomic sequences, and polymorphic sites

    SciTech Connect

    Sohocki, M.M.; Sullivan, L.S.; Daiger, S.P.

    1997-03-01

    Two frequent protein variants of glutamate pyruvate transaminase (GPT) (E.C.2.6.1.2) have been used as genetic markers in humans for more than two decades, although chromosomal mapping of the GPT locus in the 1980s produced conflicting results. To resolve this conflict and develop useful DNA markers for this gene, we isolated and characterized cDNA and genomic clones of GPT. We have definitively mapped human GPT to the terminus of 8q using several methods. First, two cosmids shown to contain the GPT sequence were derived from a chromosome 8-specific library. Second, by fluorescence in situ hybridization, we mapped the cosmid containing the human GPT gene to chromosome band 8q24.3. Third, we mapped the rat gpt cDNA to the syntenic region of rat chromosome 7. Finally, PCR primers specific to human GPT amplify sequences contained within a {open_quotes}half-YAC{close_quotes} from the long arm of chromosome 8, that is, a YAC containing the 8q telomere. The human GPT genomic sequence spans 2.7 kb and consists of 11 exons, ranging in size from 79 to 243 bp. The exonic sequence encodes a protein of 495 amino acids that is nearly identical to the previously reported protein sequence of human GPT-1. The two polymorphic GPT isozymes are the result of a nucleotide substitution in codon 14. In addition, a cosmid containing the GPT sequence also contains a previously unmapped, polymorphic microsatellite sequence, D8S421. The cloned GPT gene and associated polymorphisms will be useful for linkage and physical mapping of disease loci that map to the terminus of 8q, including atypical vitelliform macular dystrophy (VMD1) and epidermolysis bullosa simplex, type Ogna (EBS1). In addition, this will be a useful system for characterizing the telomeric region of 8q. Finally, determination of the molecular basis of the GPT isozyme variants will permit PCR-based detection of this world-wide polymorphism. 22 refs., 3 figs.

  14. Density measurements of subcooled water in the temperature range of (243 and 283) K and for pressures up to 400 MPa

    NASA Astrophysics Data System (ADS)

    Romeo, Raffaella; Giuliano Albo, P. Alberto; Lorefice, Salvatore; Lago, Simona

    2016-02-01

    In this work, accurate density measurements of subcooled water (freshly double-distilled water) were performed along eight constant-mass curves in the temperature range of (243 to 283) K and in the pressure range of (140 to 400) MPa, by a pseudo-isochoric method. The experimental apparatus mainly consisted of a high pressure vessel, especially designed for this experiment, of known volume as a function of temperature and pressure, used to perform measurements in the T-p range under study. The density of subcooled water was obtained by measuring the equilibrium pressure at different temperatures, keeping the mass constant. All terms contributing to the uncertainty of subcooled water density measurements were considered; the estimated relative uncertainty, in the investigated temperature and pressure range, is about 0.07%. The experimental results were compared with the literature densities. In particular, the trend of density versus temperature for a constant mass of sample observed experimentally differs from the trend calculated by the equation provided by the International Association for Properties of Water and Steam (IAPWS-95) outside the range of validity, i.e., in the metastable region.

  15. Deletions in 14q24.1q24.3 are associated with congenital heart defects, brachydactyly, and mild intellectual disability.

    PubMed

    Oehl-Jaschkowitz, Barbara; Vanakker, Olivier M; De Paepe, Anne; Menten, Björn; Martin, Thomas; Weber, Georg; Christmann, Alexander; Krier, Romain; Scheid, Simone; McNerlan, Susan E; McKee, Shane; Tzschach, Andreas

    2014-03-01

    Interstitial deletions of chromosome band 14q24.1q24.3 are apparently very rare. We report on three unrelated patients with overlapping de novo deletions of sizes 5.4, 2.8, and 2.3 Mb in this region. While some clinical problems such as intestinal malrotation, cryptorchidism, and ectopic kidney were only observed in single patients, all three patients had mild intellectual disability, congenital heart defects (truncus arteriosus, pulmonary atresia, atrial septal defect, and/or ventricular septal defect), brachydactyly, hypertelorism, broad nasal bridge, and thin upper lips. Likely haploinsufficiency of one or several of the 19 genes in the common deleted interval (ACTN1, DCAF5, EXD2, GALNTL1, ERH, SLC39A9, PLEKHD1, CCDC177, KIAA0247, LOC100289511, SRSF5, SLC10A1, SMOC1, SLC8A3, ADAM21P1, COX16, SYNJ2BP, SYNJ2BP-COX16, ADAM21) was responsible for these manifestations, but apart from SMOC1, mutations in which cause autosomal recessive Waardenburg anophthalmia syndrome, and ACTN1, mutations in which are associated with congenital macrothrombocytopenia, no disease associations have so far been reported for the other genes. Functional studies and a systematic search for mutations or chromosome aberrations in this region will elucidate the role of individual genes in the clinical manifestations and will provide insight into the underlying biological mechanisms. PMID:24357125

  16. Pituitary deficiency and congenital infiltrating lipomatosis of the face in a girl with deletion of chromosome 1q24.3q31.1.

    PubMed

    Capra, V; Severino, M; Rossi, A; Nozza, P; Doneda, C; Perri, K; Pavanello, M; Fiorio, P; Gimelli, G; Tassano, E; Di Battista, E

    2014-02-01

    Interstitial deletions of the long arm of chromosome 1 are rare and they are classified as proximal or intermediate. The intermediate interstitial deletions span 1q24-1q32. We describe a 6-year-old girl with multiple pituitary hormone deficiency, severe cognitive impairment, bilateral cleft lip and palate, midline facial capillary malformation, erythema of hands and feet and dysplastic cranial vessels, low anti-thrombin III activity, hemifacial overgrowth due to progressive infiltrating lipomatosis with bone overgrowth, marked vascular proliferation and erythema of hands and feet, and abnormal cranial vessels. The girl's karyotype showed an apparently de novo interstitial deletion 1q24.3q31.1, which was defined by array-CGH. The deleted region contains numerous genes, but only eight (CENPL, LHX4, LAMC1, LAMC2, PTGS2, ANGPTL1, TNN, and TNR) are good candidates to explain, at least partially, the phenotype of the proposita. We, therefore, discuss the involvement of these genes and the observed phenotype. PMID:24311370

  17. Neutron capture and fission cross section of /sup 243/Am in the energy range from 5 to 250 keV

    SciTech Connect

    Wisshak, K.; Kappeler, F.

    1983-11-01

    The neutron capture and subthreshold fission cross section of /sup 243/Am was measured in the energy range from 5 to 250 keV using /sup 197/Au and /sup 235/U as the respective standards. Neutrons were produced via the /sup 7/Li(p,n) and the T(p,n) reaction with the Karlsruhe 3-MV pulsed Van de Graaff accelerator. Capture events were detected by two Moxon-Rae detectors with graphite and bismuth graphite converters, respectively. Fission events were registered by an Ne-213 liquid scintillator with pulse-shape discriminator equipment. Flight paths as short as 50 to 70 mm were used to obtain an optimum signal-to-background ratio. After correction for the different efficiency of the individual converter materials, the capture cross section could be determined with a total uncertainty of 3 to 6%. The respective values for the fission cross section are 8 to 12%. The results are compared to predictions of recent evaluations, which in some cases are severely discrepant.

  18. Susceptibility to insulin-dependent diabetes mellitus maps to a locus (IDDM11) on human chromosome 14q24.3-q31

    SciTech Connect

    Field, L.L.; Tobias, R.; Thomson, G.

    1996-04-01

    To locate genes predisposing to insulin-dependent diabetes mellitus (IDDM), an autoimmune disorder resulting from destruction of the insulin-producing pancreatic cells, we are testing linkage of IDDM susceptibility to polymorphic markers across the genome using families with two or more IDDM children. A new susceptibility locus (IDDM11) has been localized to chromosome 14q24.3-q31 by detection of significant linkage to microsatellite D14S67, using both maximum likelihood methods D14S67, using both maximum likelihood methods (LOD{sub max} = 4.0 at {theta} = 0.20) and affected sib pair (ASP) methods (P = 1 x 10{sup -5}). This represents the strongest reported evidence for linkage to any IDDM locus outside the HLA region. The subset of families in which affected children did not show increased sharing of HLA genes (HLA sharing {le}50%) provided most of the support for D14S67 linkage (LOD{sub max}4.6 at {theta} = 0.12;ASP P < 5 x 10{sup -6}). There was significant linkage heterogeneity between the HLA-defined subsets of families (P = 0.009), suggesting that IDDM11 may be an important susceptibility locus in families lacking strong HLA region predisposition. 52 refs., 2 figs., 3 tabs.

  19. New Insights into the 243Am 48Ca Reaction Products Previously Observed in the Experiments on Elements 113, 115, and 117

    SciTech Connect

    Oganessian, Yuri Ts.; Abdullin, F. Sh.; Dmitriev, S.; Gostic, J. M.; Hamilton, Joseph; Henderson, R.; Itkis, M. G.; Moody, K.; Polyakov, A. N.; Ramayya, A. V.; Roberto, James B; Rykaczewski, Krzysztof Piotr; Sagaidak, R. N.; Shaughnessy, D.; Shirokovsky, I. V.; Stoyer, M.; Subbotin, V. G.; Sukhov, A. M.; Tsyganov, Yu. S.; Utyonkov, V.; Voinov, A. A.; Vostokin, G. K.

    2012-01-01

    Results of a new series of experiments on the study of production cross sections and decay properties of the isotopes of element 115 in the reaction {sup 243}Am + {sup 48}Ca are presented. Twenty-one new decay chains originating from {sup 288}115 were established as the product of the 3n-evaporation channel by measuring the excitation function at three excitation energies of the compound nucleus {sup 291}115. The decay properties of all newly observed nuclei are in full agreement with those we measured in 2003. At the lowest excitation energy E* = 33 MeV, for the first time we registered the product of the 2n-evaporation channel, {sup 289}115, which was also observed previously in the reaction {sup 249}Bk + {sup 48}Ca as the daughter nucleus of the decay of {sup 293}117. The maximum cross section for the production of {sup 288}115 is found to be 8.5 pb at E* {approx} 36 MeV.

  20. Density measurements of subcooled water in the temperature range of (243 and 283) K and for pressures up to 400 MPa.

    PubMed

    Romeo, Raffaella; Giuliano Albo, P Alberto; Lorefice, Salvatore; Lago, Simona

    2016-02-21

    In this work, accurate density measurements of subcooled water (freshly double-distilled water) were performed along eight constant-mass curves in the temperature range of (243 to 283) K and in the pressure range of (140 to 400) MPa, by a pseudo-isochoric method. The experimental apparatus mainly consisted of a high pressure vessel, especially designed for this experiment, of known volume as a function of temperature and pressure, used to perform measurements in the T-p range under study. The density of subcooled water was obtained by measuring the equilibrium pressure at different temperatures, keeping the mass constant. All terms contributing to the uncertainty of subcooled water density measurements were considered; the estimated relative uncertainty, in the investigated temperature and pressure range, is about 0.07%. The experimental results were compared with the literature densities. In particular, the trend of density versus temperature for a constant mass of sample observed experimentally differs from the trend calculated by the equation provided by the International Association for Properties of Water and Steam (IAPWS-95) outside the range of validity, i.e., in the metastable region. PMID:26896989

  1. A unique de novo interstitial deletion of chromosome 17, del(17)(q23.2q24.3) in a female newborn with multiple congenital anomalies

    SciTech Connect

    Levin, M.L.; Shaffer, L.G.; Lewis, R.A.

    1994-09-01

    Contiguous gene or microdeletion syndromes occurring on chromosome 17p include the Smith-Magenis and Miller-Dieker syndromes associated with interstitial deletions of 17p11.2 and 17p13.3, respectively. Other cytogenetically visible interstitial deletions on chromosome 17 are quite rare or unique. We describe a newborn with a novel interstitial deletion of the long arm of chromosome 17 [del(17)(q23.2q24.3)] who died on day of life 17 during a recurrent apneic episode. We have compared our patient`s phenotype and karyotype to two reported patients with deletion 17q with minor clinical overlap. The most striking clinical features of this patient were severe intrauterine growth retardation, widespread skeletal malformations (split sutures, hypoplastic acetabulae and scapulae, vertebral anomalies, and digital hypoplasia), cutis verticis gyrata, dysmorphic facial features, and oropharyngeal malformations (absent uvula and submucous cleft palate). Mild congenital heart disease and anomalous optic nerves were also present. Parental karyotyps were normal. DNA from parents and patient has been collected and cell lines established on both parents. Genes which have been previously mapped to the region that is apparently deleted in this patient include: chorionic somatomammotropin A, growth hormone (normal), acid alpha-glucosidase, apolipoprotein H, and the alpha peptide of type 4 voltage gated sodium channel. As in other clinical cytogenetic syndromes, further descriptions of patients with similar or overlapping rearrangements in this region will be necessary to delineate genotype/phenotype correlations for chromosome 17.

  2. A novel autosomal recessive non-syndromic hearing impairment locus (DFNB47) maps to chromosome 2p25.1-p24.3.

    PubMed

    Hassan, Muhammad Jawad; Santos, Regie Lyn P; Rafiq, Muhammad Arshad; Chahrour, Maria H; Pham, Thanh L; Wajid, Muhammad; Hijab, Nadine; Wambangco, Michael; Lee, Kwanghyuk; Ansar, Muhammad; Yan, Kai; Ahmad, Wasim; Leal, Suzanne M

    2006-01-01

    Hereditary hearing impairment (HI) displays extensive genetic heterogeneity. Autosomal recessive (AR) forms of prelingual HI account for approximately 75% of cases with a genetic etiology. A novel AR non-syndromic HI locus (DFNB47) was mapped to chromosome 2p25.1-p24.3, in two distantly related Pakistani kindreds. Genome scan and fine mapping were carried out using microsatellite markers. Multipoint linkage analysis resulted in a maximum LOD score of 4.7 at markers D2S1400 and D2S262. The three-unit support interval was bounded by D2S330 and D2S131. The region of homozygosity was found within the three-unit support interval and flanked by markers D2S2952 and D2S131, which corresponds to 13.2 cM according to the Rutgers combined linkage-physical map. This region contains 5.3 Mb according to the sequence-based physical map. Three candidate genes, KCNF1, ID2 and ATP6V1C2 were sequenced, and were found to be negative for functional sequence variants. PMID:16261342

  3. A novel autosomal recessive non-syndromic hearing impairment locus (DFNB47) maps to chromosome 2p25.1-p24.3

    PubMed Central

    Hassan, Muhammad Jawad; Santos, Regie Lyn P.; Rafiq, Muhammad Arshad; Chahrour, Maria H.; Pham, Thanh L.; Wajid, Muhammad; Hijab, Nadine; Wambangco, Michael; Lee, Kwanghyuk; Ansar, Muhammad; Yan, Kai; Ahmad, Wasim; Leal, Suzanne M.

    2010-01-01

    Hereditary hearing impairment (HI) displays extensive genetic heterogeneity. Autosomal recessive (AR) forms of prelingual HI account for ~75% of cases with a genetic etiology. A novel AR non-syndromic HI locus (DFNB47) was mapped to chromosome 2p25.1-p24.3, in two distantly related Pakistani kindreds. Genome scan and fine mapping were carried out using microsatellite markers. Multipoint linkage analysis resulted in a maximum LOD score of 4.7 at markers D2S1400 and D2S262. The three-unit support interval was bounded by D2S330 and D2S131. The region of homozygosity was found within the three-unit support interval and flanked by markers D2S2952 and D2S131, which corresponds to 13.2 cM according to the Rutgers combined linkage-physical map. This region contains 5.3 Mb according to the sequence-based physical map. Three candidate genes, KCNF1, ID2 and ATP6V1C2 were sequenced, and were found to be negative for functional sequence variants. PMID:16261342

  4. Association of the −243A>G, +61450C>A Polymorphisms of the Glutamate Decarboxylase 2 (GAD2) Gene with Obesity and Insulin Level in North Indian Population

    PubMed Central

    PRAKASH, Jai; MITTAL, Balraj; AWASTHI, Shally; SRIVASTAVA, Neena

    2016-01-01

    Background: Obesity associated with type 2 diabetes, and hypertension increased mortality and morbidity. Glutamate decarboxylase 2 (GAD2) gene is associated with obesity and it regulate food intake and insulin level. We investigated the association of GAD-2gene −243A>G (rs2236418) and +61450C>A (rs992990) polymorphisms with obesity and related phenotypes. Methods: Insulin, glucose and lipid levels were estimated using standard protocols. All subjects were genotyped (PCR-RFLP) method. Results: The −243A>G polymorphism of the GAD-2 gene was significantly associated with higher risk of obesity (P<0.05). Conclusion: GAD-2 gene polymorphisms influence obesity and related phenotype in complex manner, probably by regulating the food intake, insulin and body weight. PMID:27252915

  5. X-Ray Outbursts of ESO 243-49 HLX-1: Comparison with Galactic Low-mass X-Ray Binary Transients

    NASA Astrophysics Data System (ADS)

    Yan, Zhen; Zhang, Wenda; Soria, Roberto; Altamirano, Diego; Yu, Wenfei

    2015-09-01

    We studied the outburst properties of the hyper-luminous X-ray source ESO 243-49 HLX-1, using the full set of Swift monitoring observations. We quantified the increase in the waiting time, recurrence time, and e-folding rise timescale along the outburst sequence, and the corresponding decrease in outburst duration, total radiated energy, and e-folding decay timescale, which confirms previous findings. HLX-1 spends less and less time in outburst and more and more time in quiescence, but its peak luminosity remains approximately constant. We compared the HLX-1 outburst properties with those of bright Galactic low-mass X-ray binary transients (LMXBTs). Our spectral analysis strengthens the similarity between state transitions in HLX-1 and those in Galactic LMXBTs. We also found that HLX-1 follows the nearly linear correlations between the hard-to-soft state transition luminosity and the peak luminosity, and between the rate of change of X-ray luminosity during the rise phase and the peak luminosity, which indicates that the occurrence of the hard-to-soft state transition of HLX-1 is similar to those of Galactic LMXBTs during outbursts. We found that HLX-1 does not follow the correlations between total radiated energy and peak luminosity, and between total radiated energy and e-folding rise/decay timescales we had previously identified in Galactic LMXBTs. HLX-1 would follow those correlations if the distance were several hundreds of kiloparsecs. However, invoking a much closer distance for HLX-1 is not a viable solution to this problem, as it introduces other, more serious inconsistencies with the observations.

  6. Comment on "John's stone: A possible fragment of the 1908 Tunguska meteorite" (Anfinogenov et al., 2014, Icarus 243, 139-147)

    NASA Astrophysics Data System (ADS)

    Haack, Henning; Greenwood, Richard C.; Busemann, Henner

    2016-02-01

    Anfinogenov et al. (Anfinogenov et al. [2014]. Icarus 243, 139-147) argue that a highly silicified gravelite sandstone referred to as "John's stone" could be a fragment of the long-sought-after impactor from the 1908 Tunguska event. We have analyzed the oxygen isotopic composition of two distinct samples of John's stone both kindly provided by Dr Yana Anfingenova. Both samples had very similar isotopic compositions, such that the average of the two was as follows: δ17O = 6.67 ± 0.15‰; δ18O = 12.78 ± 0.28‰; Δ17O = -0.01 ± 0.01 (errors 1SD). This value is well within the range for samples of terrestrial quartz-bearing sedimentary and metamorphic rocks. John's stone has an oxygen isotope composition and mineralogy that is unlike any known group of meteorites. If John's stone is extraterrestrial this would imply that it represents a previously unknown type of meteorite, as suggested by Anfinogenov et al. However, since sandstones can only form on a parent body with liquid water and by inference, also an atmosphere, we argue that there are only two possible parent bodies in the Solar System: the Earth and Mars. Mars can be ruled out for several reasons, including the oxygen isotopic and noble gas composition of John's stone, which is clearly distinct from martian meteorites. Consistent with the O study, the noble gases do not provide any evidence for an extraterrestrial origin of the samples. The lack of any cosmogenic noble gases (particularly striking in 3He, 21Ne, 38Ar) is consistent with a terrestrial origin or an extraterrestrial origin under large shielding. Based on the combined evidence obtained in this study we infer that John's stone is a terrestrial rock unrelated to the Tunguska impactor.

  7. A DETAILED GRAVITATIONAL LENS MODEL BASED ON SUBMILLIMETER ARRAY AND KECK ADAPTIVE OPTICS IMAGING OF A HERSCHEL-ATLAS SUBMILLIMETER GALAXY AT z = 4.243 {sup ,} {sup ,}

    SciTech Connect

    Bussmann, R. S.; Gurwell, M. A.; Fu Hai; Cooray, A.; Smith, D. J. B.; Bonfield, D.; Dunne, L.; Dye, S.; Eales, S.; Auld, R.; Baes, M.; Fritz, J.; Baker, A. J.; Cava, A.; Clements, D. L.; Dariush, A.; Coppin, K.; Dannerbauer, H.; De Zotti, G.; Hopwood, R.; and others

    2012-09-10

    We present high-spatial resolution imaging obtained with the Submillimeter Array (SMA) at 880 {mu}m and the Keck adaptive optics (AO) system at the K{sub S}-band of a gravitationally lensed submillimeter galaxy (SMG) at z = 4.243 discovered in the Herschel Astrophysical Terahertz Large Area Survey. The SMA data (angular resolution Almost-Equal-To 0.''6) resolve the dust emission into multiple lensed images, while the Keck AO K{sub S}-band data (angular resolution Almost-Equal-To 0.''1) resolve the lens into a pair of galaxies separated by 0.''3. We present an optical spectrum of the foreground lens obtained with the Gemini-South telescope that provides a lens redshift of z{sub lens} = 0.595 {+-} 0.005. We develop and apply a new lens modeling technique in the visibility plane that shows that the SMG is magnified by a factor of {mu} = 4.1 {+-} 0.2 and has an intrinsic infrared (IR) luminosity of L{sub IR} = (2.1 {+-} 0.2) Multiplication-Sign 10{sup 13} L{sub Sun }. We measure a half-light radius of the background source of r{sub s} = 4.4 {+-} 0.5 kpc which implies an IR luminosity surface density of {Sigma}{sub IR} (3.4 {+-} 0.9) Multiplication-Sign 10{sup 11} L{sub Sun} kpc{sup -2}, a value that is typical of z > 2 SMGs but significantly lower than IR luminous galaxies at z {approx} 0. The two lens galaxies are compact (r{sub lens} Almost-Equal-To 0.9 kpc) early-types with Einstein radii of {theta}{sub E1} 0.57 {+-} 0.01 and {theta}{sub E2} = 0.40 {+-} 0.01 that imply masses of M{sub lens1} = (7.4 {+-} 0.5) Multiplication-Sign 10{sup 10} M{sub Sun} and M{sub lens2} = (3.7 {+-} 0.3) Multiplication-Sign 10{sup 10} M{sub Sun }. The two lensing galaxies are likely about to undergo a dissipationless merger, and the mass and size of the resultant system should be similar to other early-type galaxies at z {approx} 0.6. This work highlights the importance of high spatial resolution imaging in developing models of strongly lensed galaxies discovered by Herschel.

  8. Evidence for sea level and monsoonally driven variations in terrigenous input to the northern East China Sea during the last 24.3 ka

    NASA Astrophysics Data System (ADS)

    Chang, Fengming; Li, Tiegang; Xiong, Zhifang; Xu, Zhaokai

    2015-06-01

    Geochemical and sedimentological analyses of core PC-1 recovered from the northern East China Sea (ECS) provide insights into variations in terrigenous input associated with sea level and climate changes over the past 24.3 ka. Based on high-resolution multiproxy records, our results suggest that the competing processes of sea level and monsoonally driven precipitation determined terrigenous input to the northern ECS. Dominance of terrigenous material, along with relatively light Globigerinoides ruber δ18O, indicates that the Last Glacial Maximum (LGM) lowstand of sea level has occurred during the period 21.5-19.6 ka, not suggesting an early slow rise but supporting the conventional LGM age of 21 ka. This LGM lowstand was terminated by the rapid sea level rise of 19 ka meltwater pulse (MWP), which is well expressed by the nearly synchronous decreases in both terrigenous detritus and mean grain size from 19.6 to 18.9 ka. MWP-1A is clearly marked in our records by a sharp reduction in terrigenous input and pronounced maxima of G. ruber δ18O at 15.3-14.8 ka, given the considerable age uncertainties of deglacial marine radiocarbon samples. A slightly increasing input of terrigenous matter is noted after 13.4 ka, potentially pointing to a sea level fall following the Inter-Allerød Cooling Period, which was seldom reported previously. Although MWP-1B did not leave robust signatures in terrigenous input, it is explicitly captured by the heavy δ18O of G. ruber and decline in mean grain size at 11.5-10.9 ka. MWP-1c probably occurred in a broad millennial interval with multiple peaks, which are robustly marked by the abrupt variations in terrigenous input and marine organic matter at 9.7-9.3 and 9.1 ka, respectively. During the late Holocene, the effect of continuously weakening monsoon precipitation overwhelmed that of stable sea level resulting in a uniform increase in the proportion of marine-derived organic matter after 5.5 ka.

  9. THE ORIGIN OF VARIABILITY OF THE INTERMEDIATE-MASS BLACK-HOLE ULX SYSTEM HLX-1 IN ESO 243-49

    SciTech Connect

    Lasota, J.-P.; Alexander, T.; Dubus, G.; Farrell, S. A.; Gehrels, N.

    2011-07-10

    The ultra-luminous (L{sub X} {approx}< 10{sup 42} erg s{sup -1}) intermediate-mass black-hole (IMBH) system HLX-1 in the ESO 243-49 galaxy exhibits variability with a possible recurrence time of a few hundred days. Finding the origin of this variability would constrain the still largely unknown properties of this extraordinary object. Since it exhibits a hardness-intensity behavior characteristic of black-hole X-ray transients, we have analyzed the variability of HLX-1 in the framework of the disk instability model that explains outbursts of such systems. We find that the long-term variability of HLX-1 is unlikely to be explained by a model in which outbursts are triggered by thermal-viscous instabilities in an accretion disk. Possible alternatives include the instability in a radiation-pressure-dominated disk but we argue that a more likely explanation is a modulated mass transfer due to tidal stripping of a star in an eccentric orbit around the IMBH. We consider an evolutionary scenario leading to the creation of such a system and estimate the probability of its observation. We conclude, using a simplified dynamical model of the post-collapse cluster, that no more than 1/100 to 1/10 of M{sub .} {approx}< 10{sup 4} M{sub sun} IMBHs-formed by runaway stellar mergers in the dense collapsed cores of young clusters-could have a few x1 M{sub sun} main-sequence star evolve to an asymptotic giant branch on an orbit eccentric enough for mass transfer at periapse, while avoiding collisional destruction or being scattered into the IMBH by two-body encounters. The finite but low probability of this configuration is consistent with the uniqueness of HLX-1. We note, however, that the actual response of a standard accretion disk to bursts of mass transfer may be too slow to explain the observations unless the orbit is close to parabolic (and hence even rarer). Also, increased heating, presumably linked to the highly time-dependent gravitational potential, could shorten the

  10. Separation of berkelium (IV) from trivalent transplutonium elements on ion-exchangers in solutions of phosphoric acid

    SciTech Connect

    Guseva, L.I.; Stepushkina, V.V.; Tikhomirova, G.S.

    1985-01-01

    The dependences of Am, Cm, Bk, Cf and Es behavior on anion- and cation-exchangers in solutions of 0.1-8.0 M H/sub 3/PO/sub 4/ on acid concentration and oxidant content in solution (KBrO/sub 3/) or in resin (PbO/sub 2/) have been studied. Significant differences in distribution coefficients of Bk and other transplutonium elements (TPE) have been found that can be explained by Bk oxidation to the tetravalent state. A simple and effective method of Bk (IV) separation from trivalent TPE has been developed. The method was applied to the isolation of isotopes Bk-249 and Bk-250; the purification factor of Bk (IV) from other TPE is 10/sup 4/-10/sub 6/ per cycle. The possibility of Bk separation from bromate and phosphate ions by its sorption on a cation-exchanger from diluted H/sub 3/PO/sub 4/ solutions with subsequent desorption by the mineral acid has been shown. 20 references, 8 figures.

  11. The ancient mammalian KRAB zinc finger gene cluster on human chromosome 8q24.3 illustrates principles of C2H2 zinc finger evolution associated with unique expression profiles in human tissues

    PubMed Central

    2010-01-01

    Background Expansion of multi-C2H2 domain zinc finger (ZNF) genes, including the Krüppel-associated box (KRAB) subfamily, paralleled the evolution of tetrapodes, particularly in mammalian lineages. Advances in their cataloging and characterization suggest that the functions of the KRAB-ZNF gene family contributed to mammalian speciation. Results Here, we characterized the human 8q24.3 ZNF cluster on the genomic, the phylogenetic, the structural and the transcriptome level. Six (ZNF7, ZNF34, ZNF250, ZNF251, ZNF252, ZNF517) of the seven locus members contain exons encoding KRAB domains, one (ZNF16) does not. They form a paralog group in which the encoded KRAB and ZNF protein domains generally share more similarities with each other than with other members of the human ZNF superfamily. The closest relatives with respect to their DNA-binding domain were ZNF7 and ZNF251. The analysis of orthologs in therian mammalian species revealed strong conservation and purifying selection of the KRAB-A and zinc finger domains. These findings underscore structural/functional constraints during evolution. Gene losses in the murine lineage (ZNF16, ZNF34, ZNF252, ZNF517) and potential protein truncations in primates (ZNF252) illustrate ongoing speciation processes. Tissue expression profiling by quantitative real-time PCR showed similar but distinct patterns for all tested ZNF genes with the most prominent expression in fetal brain. Based on accompanying expression signatures in twenty-six other human tissues ZNF34 and ZNF250 revealed the closest expression profiles. Together, the 8q24.3 ZNF genes can be assigned to a cerebellum, a testis or a prostate/thyroid subgroup. These results are consistent with potential functions of the ZNF genes in morphogenesis and differentiation. Promoter regions of the seven 8q24.3 ZNF genes display common characteristics like missing TATA-box, CpG island-association and transcription factor binding site (TFBS) modules. Common TFBS modules partly

  12. Discovery of a Neuroprotective Chemical, (S)-N-(3-(3,6-Dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(−)-P7C3-S243], with Improved Druglike Properties

    PubMed Central

    2015-01-01

    (−)-P7C3-S243 is a neuroprotective aminopropyl carbazole with improved druglike properties compared with previously reported compounds in the P7C3 class. It protects developing neurons in a mouse model of hippocampal neurogenesis and protects mature neurons within the substantia nigra in a mouse model of Parkinson’s disease. A short, enantioselective synthesis provides the neuroprotective agent in optically pure form. It is nontoxic, orally bioavailable, metabolically stable, and able to cross the blood–brain barrier. As such, it represents a valuable lead compound for the development of drugs to treat neurodegenerative diseases and traumatic brain injury. PMID:24697290

  13. Impaction grafting in the femur in cementless modular revision total hip arthroplasty: a descriptive outcome analysis of 243 cases with the MRP-TITAN revision implant

    PubMed Central

    2013-01-01

    Background We present a descriptive and retrospective analysis of revision total hip arthroplasties (THA) using the MRP-TITAN stem (Peter Brehm, Weisendorf, GER) with distal diaphyseal fixation and metaphyseal defect augmentation. Our hypothesis was that the metaphyseal defect augmentation (Impaction Bone Grafting) improves the stem survival. Methods We retrospectively analyzed the aggregated and anonymized data of 243 femoral stem revisions. 68 patients with 70 implants (28.8%) received an allograft augmentation for metaphyseal defects; 165 patients with 173 implants (71.2%) did not, and served as controls. The mean follow-up was 4.4 ± 1.8 years (range, 2.1–9.6 years). There were no significant differences (p > 0.05) between the study and control group regarding age, body mass index (BMI), femoral defects (types I-III as described by Paprosky), and preoperative Harris Hip Score (HHS). Postoperative clinical function was evaluated using the HHS. Postoperative radiologic examination evaluated implant stability, axial implant migration, signs of implant loosening, periprosthetic radiolucencies, as well as bone regeneration and resorption. Results There were comparable rates of intraoperative and postoperative complications in the study and control groups (p > 0.05). Clinical function, expressed as the increase in the postoperative HHS over the preoperative score, showed significantly greater improvement in the group with Impaction Bone Grafting (35.6 ± 14.3 vs. 30.8 ± 15.8; p ≤ 0.05). The study group showed better outcome especially for larger defects (types II C and III as described by Paprosky) and stem diameters ≥ 17 mm. The two groups did not show significant differences in the rate of aseptic loosening (1.4% vs. 2.9%) and the rate of revisions (8.6% vs. 11%). The Kaplan-Meier survival for the MRP-TITAN stem in both groups together was 93.8% after 8.8 years. [Study group 95.7% after 8.54 years ; control group 93.1% after 8

  14. Estimated (n,f) cross sections for 236,236m237,238-Np, 237,237m-Pu, and 240,241,242,242m,243,244,244m-Am isotopes

    SciTech Connect

    Younes, W; Becker, J; Britt, H

    2004-01-16

    Neutron-induced fission cross sections on targets of {sup 236,236m,237,238}Np, {sup 237,237m}Pu, and {sup 240,241,242,242m,243,244,244m}Am have been estimated for incident neutron energies of up to 6 MeV, using the ''surrogate'' technique and the ({sup 3}He,df) and ({sup 3}He,tf) reactions on stable targets to measure fission probabilities. In isotopes where low-lying isomeric states are known to exist, the (n,f) cross section on the corresponding isomeric targets has been estimated, using the surrogate technique. For targets of {sup 237}Np, {sup 241}Am, {sup 242m}Am, {sup 243}Am, measurements of the (n,f) cross section exist, and comparison with the surrogate-method results suggests that the (n,f) cross sections estimated by the surrogate technique are reliable to within 10% for incident neutron energies E{sub n}{approx}>2 MeV. Tabulated values of the estimated (n,f) cross sections are given in an appendix.

  15. The density and viscosity of aqueous solutions of sodium 2-({[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfinyl)benzimidazol-1-ide and solute-solvent molecular interactions study

    NASA Astrophysics Data System (ADS)

    Deosarkar, S. D.; Puyad, A. L.; Kattekar, P. S.; Kalyankar, T. M.

    2013-03-01

    This paper reports the measured density and viscosity of aqueous solutions of different concentrations of antiulcer drug, sodium 2-({[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfinyl)benzimidazol-1-ide at 40°C. The apparent molar volumes of different solutions were computed using density data. Apparent molar volume at infinite dilution which reflects solute-solvent interaction and S v, the parameter that represents solute-solute interaction has been determined graphically by using Masson's equation. Viscosity data has been analyzed by Jone-Dole equation. Viscosity coefficients A and B were determined and explained in terms of solute-solute, solute-solvent interactions and structure making/breaking ability of said drug.

  16. Identification and molecular confirmation of a small chromosome 10q duplication [dir dup(10)(q24.2 {r_arrow}q24.3)] inherited from a mother mosiac for the abnormality

    SciTech Connect

    Tonk, V.; Schneider, N.R.; Schultz, R.A.; Delgado, M.R.; Mao, Jen-i

    1996-01-02

    We describe a family in which two siblings exhibited developmental delay, reduced muscle tone and mild muscle weakness. Cytogenetic evaluation demonstrated that both children had a tandem duplication of a small portion of the long arm of chromosome 10 [46,XX or XY, dir dup(10)(q24.2{r_arrow}q24.3)], inherited from their clinically normal mother, who was found to be mosaic for the duplicated chromosome 10. Fluorescence in situ hybridization approaches, including total chromosome painting and the use of regional specific cosmid probes, were used to confirm the chromosome 10q origin of the duplicated material. This is the smallest confirmed duplication of this portion of chromosome 10 reported to date. 28 refs., 4 figs.

  17. Measurement of Absolute Fission Yields in the Fast Neutron-Induced Fission of Actinides: {sup 238}U, {sup 237}Np, {sup 238}Pu, {sup 240}Pu, {sup 243}Am, and {sup 244}Cm by Track-Etch-cum-Gamma Spectrometry

    SciTech Connect

    Iyer, R.H.; Naik, H.; Pandey, A.K.; Kalsi, P.C.; Singh, R.J.; Ramaswami, A.; Nair, A.G.C.

    2000-07-15

    The absolute fission yields of 46 fission products in {sup 238}U (99.9997 at.%), 46 fission products in {sup 237}Np, 27 fission products in {sup 238}Pu (99.21 at.%), 30 fission products in {sup 240}Pu (99.48 at.%), 30 fission products in {sup 243}Am (99.998 at.%), and 32 fission products in {sup 244}Cm (99.43 at.%) induced by fast neutrons were determined using a fission track-etch-cum-gamma spectrometric technique. In the case of highly alpha-active and sparingly available actinides - e.g., {sup 238}Pu, {sup 240}Pu, {sup 243}Am, and {sup 244}Cm - a novel recoil catcher technique to collect the fission products on a Lexan polycarbonate foil followed by gamma-ray spectrometry was developed during the course of this work. This completely removed interferences from (a) gamma rays of daughter products in secular equilibrium with the target nuclide (e.g., {sup 243}Am-{sup 239}Np), (b) activation products of the catcher foil [e.g., {sup 24}Na from Al(n,{alpha})], and (c) activation products of the target [e.g., {sup 238}Np from {sup 237}Np(n,{gamma}) and {sup 239}Np from {sup 238}U(n,{gamma})] reactions, making the gamma spectrometric analysis very simple and accurate. The high-yield asymmetric fission products were analyzed by direct gamma spectrometry, whereas the low-yield symmetric products (e.g., Ag, Cd, and Sb) as well as some of the asymmetric fission products (e.g., Br) and rare earths (in the case of {sup 238}U and {sup 237}Np) were radiochemically separated and then analyzed by gamma-ray spectrometry. The neutron spectra in the irradiation positions of the reactors were measured and delineated in the thermal to 10-MeV region using threshold activation detectors. The present data were compared with the ENDF/VI and UKFY2 evaluated data files. From the measured cumulative yields, the mass-chain yields have been deduced using charge distribution systematics. The mass yields, along with similar data for other fast neutron-induced fissioning systems, show several

  18. Characteristics of Symmetric and Asymmetric Fission Modes as a Function of the Compound Nucleus Excitation in the Proton-Induced Fission of 233Pa, 239Np and 243Am

    SciTech Connect

    Beresova, M.; Kliman, J.; Krupa, L.; Bogatchev, A. A.; Itkis, I. M.; Itkis, M. G.; Kniajeva, G. N.; Kondratiev, N. A.; Kozulin, E. M.; Pokrovsky, I. V.; Dorvaux, O.; Khlebnikov, S.; Lyapin, V.; Rubchenia, W.; Stuttge, L.; Trzaska, W.; Vakhtin, D.

    2007-05-22

    Average preequilibrium average statistical prescission and postscission neutron multiplicities as well as average {gamma}-ray multiplicity , average energy emitted by {gamma}-rays and average energy per one gamma quantum <{epsilon}{gamma}> as a function of mass and total kinetic energy (TKE) of fission fragments were measured in the proton-induced reactions p+232Th{yields}233Pa, p+238U{yields}239Np and p+242Pu{yields}243Am (at proton energy Ep=13, 20, 40 and 55 MeV). The fragment mass and energy distributions (MEDs) have been analyzed in terms of the multimodal fission. The decomposition of the experimental MEDs onto the MEDs of the distinct modes has been fulfilled in the framework of a method that is free from any parameterization of the distinct fission mode mass distribution shapes. The main characteristics for symmetric and asymmetric modes have been studied in their dependence on the compound nucleus composition and proton energy. The manifestation of multimodal fission in average {gamma}-ray multiplicities of fission fragments was also studied in this work.

  19. Identification of ZCCHC8 as fusion partner of ROS1 in a case of congenital glioblastoma multiforme with a t(6;12)(q21;q24.3).

    PubMed

    Coccé, Mariela C; Mardin, Balca R; Bens, Susanne; Stütz, Adrian M; Lubieniecki, Fabiana; Vater, Inga; Korbel, Jan O; Siebert, Reiner; Alonso, Cristina N; Gallego, Marta S

    2016-09-01

    Congenital gliobastoma multiforme (GBM) is rare and little is known about the molecular defects underlying the initiation and progression of this tumor type. We present a case of congenital GBM analyzed by conventional cytogenetics, fluorescence in situ hybridization, array comparative genomic hybridization and next generation sequencing. On cytogenetic analysis we detected a reciprocal translocation t(6;12)(q21;q24.3). By sequencing, the translocation was shown to form a fusion between the 5' region of ZCCHC8 and the 3' region of ROS1. RT-PCR analyses confirmed the existence of an in-frame fusion transcript with ZCCHC8 exons 1-3 joined to ROS1 exons 36-43. In addition to the ZCCHC8-ROS1 fusion, we detected a deletion in the short arm of chromosome 9, including homozygous loss of the CDKN2A/2B locus in 9p21.3 and heterozygous deletion of the HAUS6 gene in 9p22.1. The latter encodes a protein involved in faithful chromosome segregation by regulating microtubule nucleation and its deletion might be associated with the marked subclonal changes of ploidy observed in the tumor. This report adds the ZCCHC8-ROS1 fusion as oncogenic driver in GBM and supports the role of ROS1 activation in the pathogenesis of a subset of GBM. © 2016 Wiley Periodicals, Inc. PMID:27121553

  20. Rare hemoglobin variants: Hb G-Szuhu (HBB: c.243C>G), Hb G-Coushatta (HBB: c.68A>C) and Hb Mizuho (HBB: c.206T>C) in Sri Lankan families.

    PubMed

    Perera, P Shiromi; Silva, Ishari; Hapugoda, Menaka; Wickramarathne, Merita N; Wijesiriwardena, Indira; Efremov, Dimitar G; Fisher, Christopher A; Weatherall, David J; Premawardhena, Anuja

    2015-01-01

    In this short communication, we describe the clinical presentation of unusual hemoglobin (Hb), variants in three Sri Lankan cases under study for β-thalassemia intermedia (β-TI). We believe this is the first report on their occurrence in Sri Lanka as well as from the Indian subcontinent. During a molecular study performed on β-TI patients, we identified three unusual Hb variants as Hb G-Szuhu (HBB: c.243C>G), Hb G-Coushatta (HBB: c.68A>C) and Hb Mizuho (HBB: c.206T>C) in three unrelated families. Hb G-Szuhu and Hb G-Coushatta were found in combination with the common β-thalassemia (β-thal) mutation, IVS-I-5 (G>C). Both probands had mild anemia with greatly reduced red cell indices and had non palpable livers and spleens, however, by ultrasound, both were observed to be enlarged. The final Hb variant, Hb Mizuho, was identified as a heterozygous mutation found in both proband and his mother. Both family members had severe anemia and were regularly transfused and had increased red cell parameters. PMID:25572187