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Sample records for biobehavioral family model

  1. The biobehavioral family model: testing social support as an additional exogenous variable.

    PubMed

    Woods, Sarah B; Priest, Jacob B; Roush, Tara

    2014-12-01

    This study tests the inclusion of social support as a distinct exogenous variable in the Biobehavioral Family Model (BBFM). The BBFM is a biopsychosocial approach to health that proposes that biobehavioral reactivity (anxiety and depression) mediates the relationship between family emotional climate and disease activity. Data for this study included married, English-speaking adult participants (n = 1,321; 55% female; M age = 45.2 years) from the National Comorbidity Survey Replication, a nationally representative epidemiological study of the frequency of mental disorders in the United States. Participants reported their demographics, marital functioning, social support from friends and relatives, anxiety and depression (biobehavioral reactivity), number of chronic health conditions, and number of prescription medications. Confirmatory factor analyses supported the items used in the measures of negative marital interactions, social support, and biobehavioral reactivity, as well as the use of negative marital interactions, friends' social support, and relatives' social support as distinct factors in the model. Structural equation modeling indicated a good fit of the data to the hypothesized model (χ(2)  = 846.04, p = .000, SRMR = .039, CFI = .924, TLI = .914, RMSEA = .043). Negative marital interactions predicted biobehavioral reactivity (β = .38, p < .001), as did relatives' social support, inversely (β = -.16, p < .001). Biobehavioral reactivity predicted disease activity (β = .40, p < .001) and was demonstrated to be a significant mediator through tests of indirect effects. Findings are consistent with previous tests of the BBFM with adult samples, and suggest the important addition of family social support as a predicting factor in the model. PMID:24981970

  2. A Biobehavioral Model of Cancer Stress and Disease Course

    PubMed Central

    Andersen, Barbara L.; Kiecolt-Glaser, Janice K.; Glaser, Ronald

    2009-01-01

    Approximately 1 million Americans are diagnosed with cancer each year and must cope with the disease and treatments. Many studies have documented the deteriorations in quality of life that occur. These data suggest that the adjustment process is burdensome and lengthy. There is ample evidence showing that adults experiencing other long-term stressors experience not only high rates of adjustment difficulties (e.g., syndromal depression) but important biologic effects, such as persistent downregulation of elements of the immune system, and adverse health outcomes, such as higher rates of respiratory tract infections. Thus, deteriorations in quality of life with cancer are underscored if they have implications for biological processes, such as the immune system, relating to disease progression and spread. Considering these and other data, a biobehavioral model of adjustment to the stresses of cancer is offered, and mechanisms by which psychological and behavioral responses may influence biological processes and, perhaps, health outcomes are proposed. Finally, strategies for testing the model via experiments testing psychological interventions are offered. PMID:8024167

  3. Educating cancer prevention researchers in emerging biobehavioral models: lessons learned.

    PubMed

    Correa-Fernández, Virmarie; Davila, Marivel; Kamrudin, Samira A; Li, Dennis H; Noor, Syed W; Oluyomi, Abiodun O; Chang, Shine; Cameron, Carrie

    2011-12-01

    To increase the adoption of transdisciplinary research methods among future cancer prevention investigators, faculty members from The University of Texas MD Anderson Cancer Center developed a graduate-level course in biobehavioral methods in cancer prevention research. Two instructors paired by topic and area of expertise offered an hour-long lecture-based seminar every week for 15 weeks during the spring semester of 2010. Students and presenters both evaluated the overall course content and delivery method, as well as each session. A total of 11 students and 22 presenters participated in the course. In each class session, one presenter was from a behavioral science background,and the other was from a biological sciences background. Both presenters and students expressed overall satisfaction with the content and format of the course. The presentation of topics from a transdisciplinary perspective and interaction with presenters from both biological and behavioral sciences are valuable and can help junior researchers prepare to meet the emerging challenges in cancer prevention research. PMID:21720937

  4. Biobehavioral Influences on Cancer Progression

    PubMed Central

    Costanzo, Erin S.; Sood, Anil K.; Lutgendorf, Susan K.

    2010-01-01

    Synopsis This review focuses on the contributions of stress-related behavioral factors to cancer growth and metastasis and the biobehavioral mechanisms underlying these relationships. We describe behavioral factors that are important in modulation of the stress response and the pivotal role of neuroendocrine regulation in the downstream alteration of physiological pathways relevant to cancer control, including the cellular immune response, inflammation, and tumor angiogenesis, invasion, and cell-signaling pathways. Consequences for cancer progression and metastasis, as well as quality of life, are delineated. Finally, behavioral and pharmacological interventions for cancer patients with the potential to alter these biobehavioral pathways are discussed. PMID:21094927

  5. Biobehavioral Outcomes Following Psychological Interventions for Cancer Patients

    PubMed Central

    Andersen, Barbara L.

    2007-01-01

    Psychological interventions for adult cancer patients have primarily focused on reducing stress and enhancing quality of life. However, there has been expanded focus on biobehavioral outcomes—health behaviors, compliance, biologic responses, and disease outcomes—consistent with the Biobehavioral Model of cancer stress and disease course. The author reviewed this expanded focus in quasi-experimental and experimental studies of psychological interventions, provided methodologic detail, summarized findings, and highlighted novel contributions. A final section discussed methodologic issues, research directions, and challenges for the coming decade. PMID:12090371

  6. Preparation and tumor cell model based biobehavioral evaluation of the nanocarrier system using partially reduced graphene oxide functionalized by surfactant

    PubMed Central

    Wang, Yimin; Liu, Kunping; Luo, Zewei; Duan, Yixiang

    2015-01-01

    Background Currently, surfactant-functionalized nanomaterials are tending toward development of novel tumor-targeted drug carriers to overcome multidrug resistance in cancer therapy. Now, investigating the biocompatibility and uptake mechanism of specific drug delivery systems is a growing trend, but usually a troublesome issue, in simple pharmaceutical research. Methods We first reported the partially reduced graphene oxide modified with poly(sodium 4-styrenesulfonate) (PSS) as a nanocarrier system. Then, the nanocarrier was characterized by atomic force microscope, scanning electron microscope, high-resolution transmission electron microscope, ultraviolet–visible (UV-vis) spectroscopy, Fourier transform infrared spectroscopy, X-Ray powder diffraction, and Raman spectroscopy. Epirubicin (EPI) was attached to PSSG via π–π stacking, hydrogen bonding, and physical absorption to form conjugates of PSSG–EPI. The adsorption and desorption profiles, cytotoxicity coupled with drug accumulation, and uptake of PSSG and PSSG–EPI were evaluated. Finally, the subcellular behaviors, distribution, and biological fate of the drug delivery system were explored by confocal laser scanning microscope using direct fluorescence colocalization imaging and transmission electron microscopy. Results The partially reduced graphene oxide sheets functionalized by surfactant exhibit good dispersibility. Moreover, due to much less carboxyl groups retained on the edge of PSSG sheets, the nanocarriers exhibit biocompatibility in vitro. The obtained PSSG shows a high drug-loading capacity of 2.22 mg/mg. The complexes of PSSG–EPI can be transferred to lysosomes in 2 hours through endocytosis, then the drug is released in the cytoplasm in 8 hours, and ultimately EPI is delivered into cell nucleus to exhibit medicinal effects in 1 day. Conclusion The comprehensive exploration of the biological uptake mechanism of functional graphene-mediated tumor cell targeting model provides a typical

  7. Personalized Biobehavioral HIV Prevention for Women and Adolescent Girls

    PubMed Central

    Teitelman, Anne M.; Bevilacqua, Amanda W.; Jemmott, Loretta Sweet

    2013-01-01

    Background: Women and adolescent girls bear a significant burden of the global HIV pandemic. Both behavioral and biomedical prevention approaches have been shown to be effective. In order to foster the most effective combination HIV-prevention approaches for women and girls, it is imperative to understand the unique biological, social, and structural considerations that increase vulnerability to acquiring HIV within this population. Primary Study Objective: The purpose of this article is to propose novel ideas for personalized biobehavioral HIV prevention for women and adolescent girls. The central argument is that we must transcend unilevel solutions for HIV prevention toward comprehensive, multilevel combination HIV prevention packages to actualize personalized biobehavioral HIV prevention. Our hope is to foster transnational dialogue among researchers, practitioners, educators, and policy makers toward the actualization of the proposed recommendations. Methods: We present a commentary organized to review biological, social, and structural factors that increase vulnerability to HIV acquisition among women and adolescent girls. The overview is followed by recommendations to curb HIV rates in the target population in a sustainable manner. Results: The physiology of the lower female reproductive system biologically increases HIV risk among women and girls. Social (eg, intimate partner violence) and structural (eg, gender inequality) factors exacerbate this risk by increasing the likelihood of viral exposure. Our recommendations for personalized biobehavioral HIV prevention are to (1) create innovative mechanisms for personalized HIV risk—reduction assessments; (2) develop mathematical models of local epidemics; (3) prepare personalized, evidence-based combination HIV risk—reduction packages; (4) structure gender equity into society; and (5) eliminate violence (both physical and structural) against women and girls. Conclusions: Generalized programs and

  8. Biobehavioral Approaches to Cancer Progression and Survival

    PubMed Central

    Lutgendorf, Susan K.; Andersen, Barbara L.

    2014-01-01

    Over the last decade, there have been groundbreaking strides in our understanding of the multiple biological pathways by which psychosocial and behavioral factors can affect cancer progression. It is now clear that biobehavioral factors not only affect cellular immunity but both directly and indirectly modulate fundamental processes in cancer growth, including inflammation, angiogenesis, invasion, and metastasis. There is also an emerging understanding of how psychological and behavioral factors used in interventions can impact these physiological processes. This review outlines our current understanding of the physiological mechanisms by which psychological, social, and behavioral processes can affect cancer progression. The intervention literature is discussed, along with recommendations for future research to move the field of biobehavioral oncology forward. PMID:25730724

  9. Family Relational Factors in Pediatric Depression and Asthma: Pathways of Effect

    ERIC Educational Resources Information Center

    Wood, Beatrice L.; Miller, Bruce D.; Lim, Jungha; Lillis, Kathleen; Ballow, Mark; Stern, Trudy; Simmens, Samuel

    2006-01-01

    Objective: This study tested a multilevel biobehavioral family model proposing that negative family emotional climate contributes to child depressive symptoms, which in turn contribute to asthma disease severity. Parent-child relational insecurity is proposed as a mediator. Method: Children with asthma (N = 112; ages 7-18; 55% male) reported…

  10. Developmental interplay between children's biobehavioral risk and the parenting environment from toddler to early school age: Prediction of socialization outcomes in preadolescence.

    PubMed

    Kochanska, Grazyna; Boldt, Lea J; Kim, Sanghag; Yoon, Jeung Eun; Philibert, Robert A

    2015-08-01

    We followed 100 community families from toddler age to preadolescence. Each mother- and father-child dyad was observed at 25, 38, 52, 67, and 80 months (10 hr/child) to assess positive and power-assertive parenting. At age 10 (N = 82), we obtained parent- and child-reported outcome measures of children's acceptance of parental socialization: cooperation with parental monitoring, negative attitude toward substance use, internalization of adult values, and callous-unemotional tendencies. Children who carried a short serotonin transporter linked polymorphic region gene (5-HTTLPR) allele and were highly anger prone, based on anger observed in laboratory from 25 to 80 months, were classified as high in biobehavioral risk. The remaining children were classified as low in biobehavioral risk. Biobehavioral risk moderated links between parenting history and outcomes. For low-risk children, parenting measures were unrelated to outcomes. For children high in biobehavioral risk, variations in positive parenting predicted cooperation with monitoring and negative attitude toward substance use, and variations in power-assertive parenting predicted internalization of adult values and callous-unemotional tendencies. Suboptimal parenting combined with high biobehavioral risk resulted in the poorest outcomes. The effect for attitude toward substance use supported differential susceptibility: children high in biobehavioral risk who received optimal parenting had a more adaptive outcome than their low-risk peers. The remaining effects were consistent with diathesis-stress. PMID:25154427

  11. Developmental interplay between children’s biobehavioral risk and the parenting environment from toddler to early school age: Prediction of socialization outcomes in preadolescence

    PubMed Central

    Kochanska, Grazyna; Boldt, Lea J.; Kim, Sanghag; Yoon, Jeung Eun; Philibert, Robert A.

    2014-01-01

    We followed 100 community families from toddler age to preadolescence. Each mother- and father-child dyad was observed at 25, 38, 52, 67, and 80 months (10 hours per child) to assess positive and power-assertive parenting. At age 10 (N=82), we obtained parent- and child-reported outcome measures of children’s acceptance of parental socialization: cooperation with parental monitoring, negative attitude toward substance use, internalization of adult values, and callous-unemotional (CU) tendencies. Children who carried a short 5-HTTLPR allele and were highly anger prone, based on anger observed in laboratory from 25 to 80 months, were classified as high in biobehavioral risk. The remaining children were classified as low in biobehavioral risk. Biobehavioral risk moderated links between parenting history and outcomes. For low-risk children, parenting measures were unrelated to outcomes. For children high in biobehavioral risk, variations in positive parenting predicted cooperation with monitoring and negative attitude toward substance use, and variations in power-assertive parenting predicted internalization of adult values and CU tendencies. Suboptimal parenting combined with high biobehavioral risk resulted in the poorest outcomes. The effect for attitude toward substance use supported differential susceptibility: Children high in biobehavioral risk who received optimal parenting had a more adaptive outcome than their low-risk peers. The remaining effects were consistent with diathesis-stress. PMID:25154427

  12. Biobehavioral Measures as Outcomes: A Cautionary Tale

    PubMed Central

    Kovach, Christine R.; Woods, Diana Lynn; Devine, Elizabeth C.; Logan, Brent R.; Raff, Hershel

    2013-01-01

    This article discusses the use of biobehavioral measures as outcomes for healthcare intervention studies. Effect size (ES) values for salivary cortisol, and observation-based measures of pain and agitation are examined. Effects pre to post treatment were assessed separately for nursing home (NH) residents with and without acute psychotic symptoms. This study revealed large positive effects on both pain and agitation measures in the group with acute psychotic symptoms and small-to-medium positive effects on these same measures in the group without acute psychotic symptoms. In both of these groups the ES values were not consistently positive on the cortisol measures. Prior to determining if a measure can be used to estimate minimum clinically important differences, it is essential to consider if the biomarker will be responsive to therapy in the populations and contexts being studied. PMID:24158972

  13. Maternal parenting predicts infant biobehavioral regulation among women with a history of childhood maltreatment.

    PubMed

    Martinez-Torteya, Cecilia; Dayton, Carolyn J; Beeghly, Marjorie; Seng, Julia S; McGinnis, Ellen; Broderick, Amanda; Rosenblum, Katherine; Muzik, Maria

    2014-05-01

    Early biobehavioral regulation, a major influence of later adaptation, develops through dyadic interactions with caregivers. Thus, identification of maternal characteristics that can ameliorate or exacerbate infants' innate vulnerabilities is key for infant well-being and long-term healthy development. The present study evaluated the influence of maternal parenting, postpartum psychopathology, history of childhood maltreatment, and demographic risk on infant behavioral and physiological (i.e., salivary cortisol) regulation using the still-face paradigm. Our sample included 153 women with high rates of childhood maltreatment experiences. Mother-infant dyads completed a multimethod assessment at 7 months of age. Structural equation modeling showed that maternal positive (i.e., sensitive, warm, engaged, and joyful) and negative (i.e., overcontrolling and hostile) behaviors during interactions were associated with concurrent maternal depressive symptoms, single parent status, and low family income. In turn, positive parenting predicted improved infant behavioral regulation (i.e., positive affect and social behaviors following the stressor) and decreased cortisol reactivity (i.e., posttask levels that were similar to or lower than baseline cortisol). These findings suggest increased risk for those women experiencing high levels of depressive symptoms postpartum and highlight the importance of maternal positive interactive behaviors during the first year for children's neurodevelopment. PMID:24621516

  14. The Ocean-Hill Brownsville and Cambodian-Kent State Crises: A Biobehavioral Approach to Human Sociobiology.

    ERIC Educational Resources Information Center

    Beck, Henry

    1979-01-01

    The author traces the origin of his thinking on a biobehavioral systems approach to human sociobiology and argues that it is a fruitful alternative to sociobiological models derived from population biology and genetics. Available from Behavioral Science, Systems Science Publications, University of Louisville, Louisvilly, KY 40208; sc $3.75.…

  15. Environmental Stress and Biobehavioral Antecedents of Coronary Heart Disease.

    ERIC Educational Resources Information Center

    Krantz, David S.; And Others

    1988-01-01

    Provides an overview of research on the biobehavioral antecedents of coronary heart disease, including stressful occupational settings characterized by high demands and little control over the job, and the Type A pattern, particularly hostility and mode of anger expression (anger-in). Discusses research on physiologic responsiveness (reactivity)…

  16. Background and Design of the Profiling Biobehavioral Responses to Mechanical Support in Advanced Heart Failure (PREMISE) Study

    PubMed Central

    Lee, Christopher S.; Mudd, James O.; Gelow, Jill M.; Nguyen, Thuan; Hiatt, Shirin O.; Green, Jennifer K.; Denfeld, Quin E.; Bidwell, Julie T.; Grady, Kathleen L.

    2013-01-01

    Background Unexplained heterogeneity in response to ventricular assist device (VAD) implantation for the management of advanced heart failure impedes our ability to predict favorable outcomes, provide adequate patient and family education, and personalize monitoring and symptom management strategies. The purpose of this paper is to describe the background and design of a study entitled Profiling Biobehavioral Responses to Mechanical Support in Advanced Heart Failure (PREMISE). Study Design and Methods PREMISE is a prospective cohort study designed to a) identify common and distinct trajectories of change in physical and psychological symptom burden, b) characterize common trajectories of change in serum biomarkers of myocardial stress, systemic inflammation, and endothelial dysfunction, and c) quantify associations between symptoms and biomarkers of pathogenesis in adults undergoing VAD implantation. Latent growth mixture modeling, including parallel process and cross-classification modeling, will be used to address the study aims and will entail identifying trajectories, quantifying associations between trajectories and both clinical and quality-of-life outcomes, and identifying predictors of favorable symptom and biomarker responses to VAD implantation. Conclusion Research findings from PREMISE will be used to enhance shared patient and provider decision-making, and shape a much-needed new breed of interventions and clinical management strategies that are tailored to differential symptom and pathogenic responses to VAD implantation. PMID:23839571

  17. A biobehavioral research perspective on alcohol abuse and alcoholism.

    PubMed Central

    Brady, J V

    1988-01-01

    An empirical biobehavioral research approach to the conditions generally identified as alcohol abuse and alcoholism emphasizes the temporal ordering of participating biochemical, physiological, and behavioral events that provide an operational basis for characterizing the functional aspects of this complex disorder and identifying distinguishable features of the alcohol abuse and dependence process. The available evidence suggests that alcoholism is a condition determined by a host of continuous variables rather than an entity possessing static qualities that imply intractability. The challenge for biobehavioral research is to determine the details of how chronic and excessive alcohol drinking is generated as well as the conditions under which such overindulgence can be attenuated and prevented. Environmental context, for example, can dramatically alter the frequency and amount of alcohol intake. Such contextual malleability is suggested as an important key to at least some of the inconsistencies in the literature with regard to the conditions under which chronic and excessive alcohol intake occurs. Excessive and chronic alcohol ingestion would seem most parsimoniously viewed as a set of behaviors for which others might have been substituted, and intermittently do, rather than as a highly specific disorder or disease. Though current etiological, preventive, and therapeutic orientations emphasize the role of physical dependence and favor genetic influences as strong determinants of alcohol-related disorders, it is important to recognize that troubled drinking is malleable, waxing and then entering periods of remission, with alcohol drinking even in severely dependent individuals remaining susceptible to control by both antecedent and consequating environmental events. PMID:3141967

  18. The Ocean-Hill Brownsville and Cambodian-Kent State crises: a biobehavioral approach to human sociobiology.

    PubMed

    Beck, H

    1979-01-01

    The author traces the origin of his thinking on a biobehavioral systems approach to human sociobiology as it evolved from his observations and analyses of on-the-ground human behavior in local, Ocean-Hill Brownsville, and nationwide, Cambodia-Kent State, political crises, as well as from his naturalistic observations of face-to-face behavior in group psychotherapy. He argues that the resulting sociobiological paradigm--arrived at independently by several other workers--is a fruitful alternative to sociobiological models derived from population biology and genetics. PMID:435218

  19. Behavioral Symptoms after Breast Cancer Treatment: A Biobehavioral Approach

    PubMed Central

    Fagundes, Christopher; LeRoy, Angie; Karuga, Maryanne

    2015-01-01

    Being diagnosed and treated for breast cancer is emotionally and physically challenging. Breast cancer is the most commonly diagnosed cancer and the second leading cause of death for women in the United States. Accordingly, women with a breast cancer history are the largest group of female cancer survivors. Psychological stress substantially augments adverse autonomic, endocrine, and immune discharge, including enhanced production of proinflammatory cytokines. Importantly, inflammation is a key biological mechanism underlying the symptom cluster of pain, depression, fatigue, and sleep disturbances; there is also good evidence that inflammation contributes to breast cancer recurrence. Stress may exert direct effects on psychological and physiological risk processes. In this review, we take a biobehavioral approach to understanding predictors and mechanisms underlying somatic symptoms in breast cancer survivors. PMID:26247972

  20. Boundaries between Parent and Family Education and Family Therapy: The Levels of Family Involvement Model.

    ERIC Educational Resources Information Center

    Doherty, William J.

    1995-01-01

    Presents model that addresses issues of where to place parent and family education in the spectrum of professional services to families, and how to distinguish between education and therapy in work with families. Offers five-level model of involvement with families as an alternative to the dichotomous distinction between education and therapy.…

  1. Emerging Biobehavioral Factors of Fatigue in Sickle Cell Disease

    PubMed Central

    Ameringer, Suzanne; Smith, Wally R.

    2010-01-01

    Purpose The symptom most frequently associated with sickle cell disease (SCD) is pain, but recent research is beginning to indicate that fatigue as an increasingly important symptom of this disease upon which to focus research efforts. This article explores biological and behavioral factors that can potentially contribute to fatigue in SCD. Organizing Framework A biobehavioral framework guides this discussion of factors that may contribute to SCD fatigue. Findings The pathophysiology of the disease process, such as the profound hemolytic anemia and unpredictable vasoocclusive crises, suggests that individuals with SCD are at risk for both acute and chronic fatigue. For example, hypoxemia can cause muscle weakness and produce oxidative stress, which, in turn, increases fatigue. Sickled erythrocytes disrupt the vascular endothelium and stimulate proinflammatory cytokines, which are linked to sleep disruptions. Pain, the most notorious symptom of SCD, has a complex and mechanistically poorly understood relationship with fatigue. Conclusions Little is known about the symptom of fatigue in SCD. Considering the biological and behavioral factors of SCD that could potentially contribute to fatigue, there is a great need for research on the nature and potential mechanisms of fatigue in SCD. Clinical Relevance Fatigue in SCD may negatively affect quality of life. Understanding factors that may contribute to fatigue aids the clinician in identifying causes and determining treatment. PMID:21342421

  2. Biobehavioral pain profile in individuals with chronic spine pain.

    PubMed

    Matteliano, Deborah; Scherer, Yvonne Krall; Chang, Yu-Ping

    2014-03-01

    Pain in the spine is the most frequently described pain problem in primary care, afflicting at least 54 million Americans. When spinal pain becomes chronic, the prognosis for recovery is poor, often leading to disability and reduced quality of life. Clinical treatment is inadequate, often focusing on physical pathology alone. To improve treatment outcomes for chronic pain as recommended by current guidelines, the Biobehavioral Pain Profile (BPP), which includes six pain response subscales, was developed to guide cognitive behavioral therapy (CBT). The purpose of this study was to describe the BPP in 100 individuals with chronic spine pain and examine the associations between the BPP and important clinical outcomes, including chronic pain, disability, and quality of life. Participants reported a high level of pain, a low quality of life, and a high level of disability despite receiving treatment with opioids. Scores on BPP subscales including evaluating loss of control, past and current experience, physiologic responsivity, and thoughts of disease progression were elevated, indicating a need for CBT. Five of the six BPP subscales had a significant association with quality of life, chronic pain, and disability with the thought of disease progression being a strong factor for most of the clinical outcome variables. By identifying BPP, clinicians can provide appropriate treatments to improve individuals' quality of life and prevent further disability. Further study using the BPP to guide CBT is needed. PMID:24602429

  3. A Biobehavioral Perspective on Depressive Symptoms in Patients with a Cerebral Astrocytoma

    PubMed Central

    Starkweather, Angela; Sherwood, Paula; Lyon, Debra E.; McCain, Nancy L.; Bovbjerg, Dana Howard; Broaddus, William C.

    2013-01-01

    Over 51,000 individuals are diagnosed with a primary brain tumor in the United States each year, and for those with the most common type of malignant tumor, an astrocytoma, almost 75% will die within five years of diagnosis. While surgery, radiation, and chemotherapy have improved length of survival, mortality remains high, which underscores the need to understand how other factors affect the disease trajectory. Several recent studies have shown that depressive symptoms are independently associated with reduced quality of life and survival time after controlling for medial variables in patients with an astrocytoma. Thus, depressive symptoms represent a significant risk factor for adverse outcomes in this patient population. A growing body of evidence indicates that depressive symptoms are linked to underlying biological phenomena, particularly inflammatory activation modulated through increased peripheral levels of proinflammatory cytokines. Recent research has shown that neoplastic astrocytes respond to elevated proinflammatory cytokine levels by secreting immune mediators within the central nervous system, including cytokines and glial fibrillary acidic protein (GFAP) that promote astrogliosis and angiogenesis, and may increase tumor growth and metastasis. However, because these biological factors have not as yet been measured in conjunction with depressive symptoms in these patients, little is known about the interactions that potentially influence the treatment trajectory. In order to guide future research and provide a deeper understanding of the factors that may influence depressive symptoms and length of survival in patients with an astrocytoma, a review of the literature was undertaken. Publications over the past ten years were analyzed to examine the theoretical models and measures of depressive symptoms used in previous research. While numerous studies have documented the relationship between depression and reduced length of survival, there were several

  4. Implications of Biobehavioral States for the Education and Treatment of Students with the Most Profoundly Handicapping Conditions.

    ERIC Educational Resources Information Center

    Guess, Doug; And Others

    1988-01-01

    Implications of biobehavioral state measures for the assessment of students with profoundly handicapping conditions are discussed in relation to similar behaviors observed in infants and among persons recovering from severe head trauma. Biobehavioral states assessed include: asleep-inactive, asleep-active, drowsy, awake-inactive-alert,…

  5. Community implementation outcomes of Attachment and Biobehavioral Catch-up.

    PubMed

    Caron, E B; Weston-Lee, Patria; Haggerty, Danielle; Dozier, Mary

    2016-03-01

    Bringing evidence-based treatments to community practice is a critical challenge for the field. When implemented in the community, evidence-based treatments often fail to provide the benefits shown in laboratory settings. Therefore, when evidence-based treatments are transported to the community, it is essential to investigate implementation process and outcomes. The present study assessed whether Attachment and Biobehavioral Catch-up (ABC), an intervention for high-risk parents that has been shown to be efficacious in randomized clinical trials (RCTs), changed parent behavior in a community-based setting. This study examined data collected from 78 cases by 9 parent coaches in a diverse community setting in Hawaii, and compared data to benchmarks from RCTs. Parent coach fidelity was coded from intervention session video clips, and was also compared with benchmarks. Caregivers participating in ABC were primarily birth parents, and most were referred through Child Protective Services involvement or for reasons of harsh parenting or neglect. Parental behavior was assessed before and after intervention using a semi-structured play task. Increases in parental following the lead and delight, and decreases in parental intrusiveness, were observed; these changes were comparable to effect sizes observed in RCTs. Intent to treat analyses were conducted using behavioral data from videotaped sessions, and suggested that ABC also improved following the lead in parents who subsequently dropped out of treatment. These results support the viability of ABC for enhancing parenting behavior among parents at high risk for maltreatment, and demonstrate that parent coaches in community agencies can successfully implement ABC. PMID:26746112

  6. The biobehavioral consequences of psychogenic stress in a small, social primate (Callithrix jacchus jacchus).

    PubMed

    Johnson, E O; Kamilaris, T C; Carter, C S; Calogero, A E; Gold, P W; Chrousos, G P

    1996-09-01

    The biobehavioral consequences of psychogenic stress were examined using neuroendocrine and ethological methods in a captive colony of common marmosets (Callithrix jacchus jacchus). Specifically, hypothalamic-pituitary-adrenal (HPA) axis reactivity was evaluated as a function of gender and social status in four consecutive social environments [(1) stable heterosexual pairs; (2) isolation; (3) unstable peer groups; and (4) stable peer groups], by measuring both basal plasma cortisol, adrenocorticotropic hormone (ACTH) and beta-endorphin concentrations and responsiveness of these hormones to dexamethasone, ovine corticotropin-releasing hormone (oCRH), and ACTH1-24. Socially stressful conditions, such as isolation and peer group formation, were associated with increased HPA axis function and behavioral arousal, and individual profiles were related to gender and social status. Hormonal levels prior to group formation predicted subsequent status in peer groups. Basal morning concentrations of plasma cortisol, as well as cortisol responsiveness to dexamethasone suppression, were sensitive indices of HPA axis arousal during periods of social stress. The context-dependent development of hormonal and behavioral profiles, reminiscent of depression and/or anorexia nervosa, suggests that the common marmoset may be a useful model of psychiatric hypercortisolism. PMID:8874833

  7. Ordinary Variations in Human Maternal Caregiving in Infancy and Biobehavioral Development in Early Childhood: A Follow-up Study

    PubMed Central

    Hane, Amie Ashley; Henderson, Heather A.; Fox, Nathan A.; Reeb-Sutherland, Bethany C.

    2016-01-01

    Rodent models of early caregiving find that pups reared by dams providing low levels of early stimulation subsequently display heightened stress reactivity and social aggression. We examined these effects in humans by investigating the effects of early caregiving on markers of biobehavioral development at ages 2 and 3 years. This study extended the findings reported by Hane and Fox (2006) in which 185 mothers and infants were observed and scored for variations in maternal caregiving behavior (MCB) at age 9 months. Relative to young children who received high quality MCB in infancy, those who received low-quality MCB showed significantly higher socially inhibited behavior with adults, right frontal electroencephalographam (EEG) asymmetry, aggressive play, and maternal reported internalizing behavior problems and anger proneness. These effects were independent of early temperamental reactivity. Results parallel rodent models and demonstrate that ordinary variations in MCB influence stress reactivity and social behavior in young children. (149 words) PMID:20806328

  8. A biobehavioral approach to understanding obesity and the development of obesogenic illnesses among Latino immigrants in the United States.

    PubMed

    D'Alonzo, Karen T; Johnson, Shanda; Fanfan, Dany

    2012-10-01

    The prevalence of obesity and obesity-related illnesses is higher among Hispanics (Latinos) than other racial and ethnic groups, and rates increase exponentially with the number of years living in the United States. Mounting evidence suggests that the origins of many chronic illnesses among disadvantaged minority groups may lie with cumulative exposure to chronic psychological and physiological stressors through the biobehavioral process of allostatic load (AL). Among immigrant Latinos, acculturation stress may contribute to an increase in AL and thus may be an independent risk factor for the development of obesity and obesogenic illnesses. The purpose of this theoretical article is to present a proposed model of the effects of acculturation stress on AL and obesity among Latino immigrants. Such a model can be useful to guide intervention efforts to decrease obesity among immigrant Latinos by adding education, skill building, and social integration strategies to healthy eating and physical activity to reduce the deleterious impact of acculturation stress. PMID:22923710

  9. Intervening with Foster Parents to Enhance Biobehavioral Outcomes among Infants and Toddlers

    ERIC Educational Resources Information Center

    Dozier, Mary; Bick, Johanna; Bernard, Kristin

    2011-01-01

    Children in foster care face a number of challenges that threaten their ability to form attachment relationships with foster parents and to regulate their behavior and biology. The authors describe the Attachment and Biobehavioral Catch-Up (ABC) intervention, an evidence-based intervention aimed at helping foster children develop trusting…

  10. Cancer Patients with Major Depressive Disorder: Testing a Biobehavioral/Cognitive Behavior Intervention

    ERIC Educational Resources Information Center

    Brothers, Brittany M.; Yang, Hae-Chung; Strunk, Daniel R.; Andersen, Barbara L.

    2011-01-01

    Objective: In this Phase II trial, we evaluated a novel psychological treatment for depressed patients coping with the stresses of cancer. Effectiveness of a combined biobehavioral intervention (BBI) and cognitive behavior therapy (CBT) was studied. Method: Participants were 36 cancer survivors (mean age = 49 years; 88% Caucasian; 92% female)…

  11. Brief Report: A Pilot Study of Parent-Child Biobehavioral Synchrony in Autism Spectrum Disorder

    ERIC Educational Resources Information Center

    Baker, Jason K.; Fenning, Rachel M.; Howland, Mariann A.; Baucom, Brian R.; Moffitt, Jacquelyn; Erath, Stephen A.

    2015-01-01

    The theory of biobehavioral synchrony proposes that the predictive power of parent-child attunement likely lies in the manner with which behaviors are aligned with relevant biological processes. Symptoms of autism spectrum disorder (ASD) may challenge the formation of behavioral and physiological synchrony, but maintenance of such parent-child…

  12. Early Father Involvement Moderates Biobehavioral Susceptibility to Mental Health Problems in Middle Childhood

    ERIC Educational Resources Information Center

    Boyce, W. Thomas; Essex, Marilyn J.; Alkon, Abbey; Goldsmith, H. Hill; Kraemer, Helena C.; Kupfer, David J.

    2006-01-01

    Objective: To study how early father involvement and children's biobehavioral sensitivity to social contexts interactively predict mental health symptoms in middle childhood. Method: Fathers' involvement in infant care and maternal symptoms of depression were prospectively ascertained in a community-based study of child health and development in…

  13. Familial Dysautonomia: Mechanisms and Models.

    PubMed

    Dietrich, Paula; Dragatsis, Ioannis

    2016-08-01

    Hereditary Sensory and Autonomic Neuropathies (HSANs) compose a heterogeneous group of genetic disorders characterized by sensory and autonomic dysfunctions. Familial Dysautonomia (FD), also known as HSAN III, is an autosomal recessive disorder that affects 1/3,600 live births in the Ashkenazi Jewish population. The major features of the disease are already present at birth and are attributed to abnormal development and progressive degeneration of the sensory and autonomic nervous systems. Despite clinical interventions, the disease is inevitably fatal. FD is caused by a point mutation in intron 20 of the IKBKAP gene that results in severe reduction in expression of IKAP, its encoded protein. In vitro and in vivo studies have shown that IKAP is involved in multiple intracellular processes, and suggest that failed target innervation and/or impaired neurotrophic retrograde transport are the primary causes of neuronal cell death in FD. However, FD is far more complex, and appears to affect several other organs and systems in addition to the peripheral nervous system. With the recent generation of mouse models that recapitulate the molecular and pathological features of the disease, it is now possible to further investigate the mechanisms underlying different aspects of the disorder, and to test novel therapeutic strategies. PMID:27494199

  14. Family Stress: A Coping Model for Intervention.

    ERIC Educational Resources Information Center

    Zeitlin, Shirley; Rosenblatt, William P.

    A support program was developed at the John F. Kennedy Medical Center in Edison, New Jersey for families of handicapped children (from birth to the age of 3) who are involved in an early intervention program. A cognitive-behavioral model (the Coping with Stress Model) was designed to help families assess coping effectiveness. The process, which…

  15. Teaching-Family Model: Insuring Quality Practice

    ERIC Educational Resources Information Center

    McElgunn, Peggy

    2012-01-01

    The Teaching-Family Model was one of the earliest approaches to be supported by an extensive research base. As it has evolved over four decades, it retains the focus on teaching and learning but incorporates a strength- and relationship-based orientation. The model is also unique in gathering ongoing practice-based evidence to insure quality.

  16. A family of lowered isothermal models

    NASA Astrophysics Data System (ADS)

    Gieles, Mark; Zocchi, Alice

    2015-11-01

    We present a family of self-consistent, spherical, lowered isothermal models, consisting of one or more mass components, with parametrized prescriptions for the energy truncation and for the amount of radially biased pressure anisotropy. The models are particularly suited to describe the phase-space density of stars in tidally limited, mass-segregated star clusters in all stages of their life-cycle. The models extend a family of isotropic, single-mass models by Gomez-Leyton and Velazquez, of which the well-known Woolley, King and Wilson (in the non-rotating and isotropic limit) models are members. We derive analytic expressions for the density and velocity dispersion components in terms of potential and radius, and introduce a fast model solver in PYTHON (LIMEPY), that can be used for data fitting or for generating discrete samples.

  17. The Family FIRO Model: A Modest Proposal for Organizing Family Treatment.

    ERIC Educational Resources Information Center

    Doherty, William J.; Colangelo, Nicholas

    1984-01-01

    Presents a model for organizing family issues and family treatment. Schutz's Fundamental Interpersonal Relations Orientation (FIRO) model is offered as a framework for organizing family issues into inclusion, control, and affection categories, constituting a logical hierarchy of core issues to be dealt with in treating multiproblem families. (JAC)

  18. The Family FIRO Model: The Integration of Group Theory and Family Theory.

    ERIC Educational Resources Information Center

    Colangelo, Nicholas; Doherty, William J.

    1988-01-01

    Presents the Family Fundamental Interpersonal Relations Orientation (Family FIRO) Model, an integration of small-group theory and family therapy. The model is offered as a framework for organizing family issues. Discusses three fundamental issues of human relatedness and their applicability to group dynamics. (Author/NB)

  19. Emphases of the Major Family Therapy Models: A Family FIRO Analysis.

    ERIC Educational Resources Information Center

    Doherty, William J.; And Others

    1985-01-01

    Analyzes 13 models of family therapy according to their special emphases on the Family FIRO (Fundamental Interpersonal Relationship Orientation) model's dimensions of inclusion, control, and intimacy. Final conceptual analysis of models indicated that four family therapy models emphasized inclusion as a primary focus, four emphasized control, and…

  20. Graphical Models via Univariate Exponential Family Distributions

    PubMed Central

    Yang, Eunho; Ravikumar, Pradeep; Allen, Genevera I.; Liu, Zhandong

    2016-01-01

    Undirected graphical models, or Markov networks, are a popular class of statistical models, used in a wide variety of applications. Popular instances of this class include Gaussian graphical models and Ising models. In many settings, however, it might not be clear which subclass of graphical models to use, particularly for non-Gaussian and non-categorical data. In this paper, we consider a general sub-class of graphical models where the node-wise conditional distributions arise from exponential families. This allows us to derive multivariate graphical model distributions from univariate exponential family distributions, such as the Poisson, negative binomial, and exponential distributions. Our key contributions include a class of M-estimators to fit these graphical model distributions; and rigorous statistical analysis showing that these M-estimators recover the true graphical model structure exactly, with high probability. We provide examples of genomic and proteomic networks learned via instances of our class of graphical models derived from Poisson and exponential distributions. PMID:27570498

  1. A Model of Family Background, Family Process, Youth Self-Control, and Delinquent Behavior in Two-Parent Families

    ERIC Educational Resources Information Center

    Jeong, So-Hee; Eamon, Mary Keegan

    2009-01-01

    Using data from a national sample of two-parent families with 11- and 12-year-old youths (N = 591), we tested a structural model of family background, family process (marital conflict and parenting), youth self-control, and delinquency four years later. Consistent with the conceptual model, marital conflict and youth self-control are directly…

  2. Biobehavioral Intervention for Cancer Stress: Conceptualization, Components, and Intervention Strategies

    ERIC Educational Resources Information Center

    Andersen, Barbara L.; Golden-Kreutz, Deanna M.; Emery, Charles F.; Thiel, Debora L.

    2009-01-01

    Trials testing the efficacy of psychological interventions for cancer patients had their beginnings in the 1970s. Since then, hundreds of trials have found interventions to be generally efficacious. In this article, we describe an intervention grounded in a conceptual model that includes psychological, behavioral, and biological components. It is…

  3. Three Family Models from the Heterotic String

    SciTech Connect

    Raby, Stuart

    2005-12-02

    In this talk I outline work done in collaboration with R.J. Zhang and T. Kobayashi. We show how to construct the equivalent of three family orbifold GUTs in five dimensions from the heterotic string. I focus on one particular model with E(6) gauge symmetry in 5D, the third family and Higgs doublet coming from the 5D bulk and the first two families living on 4D SO(10) branes. Note the E(6) gauge symmetry is broken to Pati-Salam in 4D which subsequently breaks to the Standard Model gauge symmetry via the Higgs mechanism. The model has two flaws, one fatal and one perhaps only unaesthetic. The model has a small set of vector-like exotics with fractional electromagnetic charge. Unfortunately not all of these states obtain mass at the compactification scale. This flaw is fatal. The second problem is R parity violating interactions. These problems may be avoidable in alternate orbifold compactification schemes. It is these problems which we discuss in this talk.

  4. Relationships between environmental stressors and stress biobehavioral responses of preterm infants in NICU.

    PubMed

    Peng, Niang-Huei; Bachman, Jean; Jenkins, Ruth; Chen, Chao-Huei; Chang, Yue-Cune; Chang, Yu-Shan; Wang, Teh-Ming

    2013-10-01

    Although research has demonstrated that the neonatal intensive care unit (NICU) is a stressful environment for preterm and high-risk infants, little research validates the suspected relationships between infant biobehavioral responses and environmental stress in the NICU. This exploratory study examined the relationship between environmental stress and biobehavioral responses of preterm infants. The study used a repeated-measures research design to examine research variables in one group of preterm infants. Measurements of research variables were recorded every 2 minutes during two 60-minute observation periods for each research day (1 hour in the morning and 1 hour in the afternoon) and conducted over 2 days. A convenience sample of 37 preterm infants was recruited from 2 medical centers in Taiwan. A total of 4164 observations were made and recorded during the study. There was a statistically significant (P < .05) relationship between environmental stressors and changes in physiological signals. There were also statistically significant (P < .05) relationships between environmental stress and some specific stress behaviors. This research is applicable to neonatal clinical practice because it demonstrates the importance of recognizing the preterm infant's biological stress responses to environmental stressors, allowing for early interventions to reduce the possibility of more serious physiological or pathological changes in the status of the preterm infant. PMID:24042180

  5. Psychology of Supplementation in Sport and Exercise: Motivational Antecedents and Biobehavioral Outcomes

    NASA Astrophysics Data System (ADS)

    Lutz, Rafer; Arent, Shawn

    Research concerning the physiological and biobehavioral effects of supplements commonly used in sport or exercise settings has multiplied rapidly over the last decade. However, less attention has been directed to understanding the motivational pathways leading to sport and exercise supplement use. This chapter summarizes known usage rates for sport/fitness supplements and describes motivational theories and constructs that may be of use for understanding individuals' use of these substances. In this respect, we contend that researchers should consider behavioral approaches, the theory of planned behavior, balance theory, achievement goal theory, social physique anxiety, and muscle dysmorphia as useful for developing an understanding of the psychological influences on supplement use. For some of the latter theories/constructs, research has already shown support for their explanatory abilities, whereas research is scant and the utility for understanding sport/exercise supplement use is yet to be determined for many of the theories. In addition to describing the motivation behind supplement use, this chapter summarizes the biobehavioral effects of a select group of supplements commonly used to improve performance, fitness, or health. Specifically, we consider psychobiological effects of caffeine, creatine, Ginkgo biloba, and St. John's wort related to enhanced arousal, improved memory and cognition, enhanced brain function and protection, and reduced depression. There is promising initial evidence for the efficacy of these compounds in producing favorable psychological outcomes, although certain shortcomings of many studies on these compounds must be taken into account before reaching definitive conclusions.

  6. Family Ranching and Farming: A Consensus Management Model to Improve Family Functioning and Decrease Work Stress.

    ERIC Educational Resources Information Center

    Zimmerman, Toni Schindler; Fetsch, Robert J.

    1994-01-01

    Notes that internal and external threats could squeeze ranch and farm families out of business. Offers six-step Consensus Management Model that combines strategic planning with psychoeducation/family therapy. Describes pilot test with intergenerational ranch family that indicated improvements in family functioning, including reduced stress and…

  7. Family Stress and Adaptation to Crises: A Double ABCX Model of Family Behavior.

    ERIC Educational Resources Information Center

    McCubbin, Hamilton I.; Patterson, Joan M.

    Recent developments in family stress and coping research and a review of data and observations of families in a war-induced crisis situation led to an investigation of the relationship between a stressor and family outcomes. The study, based on the Double ABCX Model in which A (the stressor event) interacts with B (the family's crisis-meeting…

  8. An Examination of Family Communication within the Core and Balance Model of Family Leisure Functioning

    ERIC Educational Resources Information Center

    Smith, Kevin M.; Freeman, Patti A.; Zabriskie, Ramon B.

    2009-01-01

    The purpose of this study was to examine family communication within the core and balance model of family leisure functioning. The study was conducted from a youth perspective of family leisure and family functioning. The sample consisted of youth (N= 95) aged 11 - 17 from 25 different states in the United States. Path analyses indicated that…

  9. A Process Model of Family Formation and Development

    ERIC Educational Resources Information Center

    Garland, Diana R.

    2012-01-01

    Theoretical models of family formation have assumed sexual coupling as the foundation of family life. This article proposes instead a model of family formation predicated on the processes of taking care of one another, eating together, and sharing life together. The interpersonal dynamics that distinguish a family from other close relationships…

  10. Childhood negative emotionality predicts biobehavioral dysregulation fifteen years later.

    PubMed

    Hagan, Melissa J; Luecken, Linda J; Modecki, Kathryn L; Sandler, Irwin N; Wolchik, Sharlene A

    2016-09-01

    The temperamental trait of negative emotionality (NE) plays an important role in maladaptation among adults experiencing significant life stress. However, the prospective relation between childhood NE and subsequent interrelated behavioral, emotional, and biological dysregulation in later life has not yet been established among children who experience early adversity. Using a longitudinal sample of youth who experienced parental divorce during childhood (N = 160; 53% male; 83% White), we tested the hypothesis that childhood NE would predict physiological, emotional, and behavioral dysregulation 15 years later. NE was assessed by maternal report when youth were between 9 and 12 years old. Fifteen years later, young adults (mean age = 25.55 years) participated in a psychosocial stress task to assess cortisol reactivity and reported on internalizing symptoms and problematic alcohol use. Structural equation modeling revealed that higher childhood NE predicted significantly greater alcohol use, internalizing symptoms, and total cortisol output during a stress task 15 years later. Importantly, these findings held after adjusting for childhood internalizing symptoms. In addition, problematic alcohol use was associated with greater cortisol reactivity and internalizing symptoms. Findings suggest that childhood NE is a critical risk marker for interrelated forms of dysregulation in young adulthood among at-risk youth. (PsycINFO Database Record PMID:27100364

  11. Behavioral Health Issues among American Indians and Alaska Natives: Explorations on the Frontiers of the Biobehavioral Sciences.

    ERIC Educational Resources Information Center

    Manson, Spero M., Ed.; Dinges, Norman G., Ed.

    1988-01-01

    The nine major overview and position papers contained in the monograph were originally presented at a conference held for the purpose of reviewing, from the Native American perspective, the National Institute of Medicine's comprehensive volume, "Health and Behavior: Frontiers of Research in the Biobehavioral Sciences." The papers, each of which…

  12. Exponential family models and statistical genetics.

    PubMed

    Palmgren, J

    2000-02-01

    This article describes the evolution of applied exponential family models, starting at 1972, the year of publication of the seminal papers on generalized linear models and on Cox regression, and leading to multivariate (i) marginal models and inference based on estimating equations and (ii) random effects models and Bayesian simulation-based posterior inference. By referring to recent work in genetic epidemiology, on semiparametric methods for linkage analysis and on transmission/disequilibrium tests for haplotype transmission this paper illustrates the potential for the recent advances in applied probability and statistics to contribute to new and unified tools for statistical genetics. Finally, it is emphasized that there is a need for well-defined postgraduate education paths in medical statistics in the year 2000 and thereafter. PMID:10826159

  13. Total force fitness: the military family fitness model.

    PubMed

    Bowles, Stephen V; Pollock, Liz Davenport; Moore, Monique; Wadsworth, Shelley MacDermid; Cato, Colanda; Dekle, Judith Ward; Meyer, Sonia Wei; Shriver, Amber; Mueller, Bill; Stephens, Mark; Seidler, Dustin A; Sheldon, Joseph; Picano, James; Finch, Wanda; Morales, Ricardo; Blochberger, Sean; Kleiman, Matthew E; Thompson, Daniel; Bates, Mark J

    2015-03-01

    The military lifestyle can create formidable challenges for military families. This article describes the Military Family Fitness Model (MFFM), a comprehensive model aimed at enhancing family fitness and resilience across the life span. This model is intended for use by Service members, their families, leaders, and health care providers but also has broader applications for all families. The MFFM has three core components: (1) family demands, (2) resources (including individual resources, family resources, and external resources), and (3) family outcomes (including related metrics). The MFFM proposes that resources from the individual, family, and external areas promote fitness, bolster resilience, and foster well-being for the family. The MFFM highlights each resource level for the purpose of improving family fitness and resilience over time. The MFFM both builds on existing family strengths and encourages the development of new family strengths through resource-acquiring behaviors. The purpose of this article is to (1) expand the military's Total Force Fitness (TFF) intent as it relates to families and (2) offer a family fitness model. This article will summarize relevant evidence, provide supportive theory, describe the model, and proffer metrics that support the dimensions of this model. PMID:25735013

  14. Participatory Action Research as a Model for Conducting Family Research.

    ERIC Educational Resources Information Center

    Turnbull, Ann P.; Friesen, Barbara J.; Ramirez, Carmen

    1998-01-01

    This article discusses a participatory action research (PAR) approach to conducting family research. It proposes a model of PAR implementation level including the options of family members as research leaders and researchers as ongoing advisors, researchers and family members as coresearchers, and researches as leaders, and family members as…

  15. Economic Disadvantage in Complex Family Systems: Expansion of Family Stress Models

    ERIC Educational Resources Information Center

    Barnett, Melissa A.

    2008-01-01

    Economic disadvantage is associated with multiple risks to early socioemotional development. This article reviews research regarding family stress frameworks to model the pathways from economic disadvantage to negative child outcomes via family processes. Future research in this area should expand definitions of family and household to incorporate…

  16. Family Economic Pressure and Adolescent Suicidal Ideation: Application of the Family Stress Model

    ERIC Educational Resources Information Center

    Yoder, Kevin A.; Hoyt, Dan R.

    2005-01-01

    This study used a sample of 501 families from the Mississippi Delta region to examine the feasibility of the Family Stress Model for understanding adolescent suicidal ideation. The results indicated that family economic pressure was related to parental depressive symptoms, which, in turn, was related to parental hostile behavior and physical…

  17. Capturing the Family Context of Emotion Regulation: A Family Systems Model Comparison Approach

    ERIC Educational Resources Information Center

    Fosco, Gregory M.; Grych, John H.

    2013-01-01

    Several dimensions of family functioning are recognized as formative influences on children's emotion regulation. Historically, they have been studied separately, limiting our ability to understand how they function within the family system. The present investigation tested models including family emotional climate, interparental conflict,…

  18. Families with Noncompliant Children: Applications of the Systemic Model.

    ERIC Educational Resources Information Center

    Neilans, Thomas H.; And Others

    This paper describes the application of a systems approach model to assessing families with a labeled noncompliant child. The first section describes and comments on the applied methodology for the model. The second section describes the classification of 61 families containing a child labeled by the family as noncompliant. An analysis of data…

  19. Family boundary characteristics, work-family conflict and life satisfaction: A moderated mediation model.

    PubMed

    Qiu, Lin; Fan, Jinyan

    2015-10-01

    Although work-family border and boundary theory suggest individuals' boundary characteristics influence their work-family relationship, it is largely unknown how boundary flexibility and permeability mutually influence work-family conflict and subsequent employee outcomes. Moreover, the existing work-family conflict research has been mainly conducted in the United States and other Western countries. To address these gaps in the work-family literature, the present study examines a moderated mediation model regarding how family boundary characteristics may influence individuals' work-family conflict and life satisfaction with a sample of 278 Chinese full-time employees. Results showed that employees' family flexibility negatively related to their perceived work interference with family (WIF) and family interference with work (FIW), and both these two relationships were augmented by individuals' family permeability. In addition, WIF mediated the relationship between family flexibility and life satisfaction; the indirect effect of family flexibility on life satisfaction via WIF was stronger for individuals with higher family permeability. The theoretical and managerial implications of these findings are discussed. PMID:25331584

  20. Stress-related asthma and family therapy: Case study

    PubMed Central

    2012-01-01

    This paper applies the Biobehavioral Family Model (BBFM) of stress- related illness to the study and treatment of an adolescent with intractable asthma. The model is described, along with supportive research findings. Then a case study is presented, demonstrating how the model is clinically applied. We tell the story of an asthmatic adolescent presenting for therapy due to her intense asthmatic crises, and the case is presented to exemplify how the BBFM can help understand the family-psychobiological contribution to exacerbation of disease activity, and therefore guide treatment towards the amelioration of severe physical symptoms. Facets of the patient’s intra-familial interactions are consistent with the BBFM, which support clinical validation of the model. In the case described, it is likely that additional asthma medications would not have had the desired ameliorative effect, because they did not target the family relational processes contributing to the symptoms. The recognition of the influences of family relational processes on the disease was crucial for effective intervention. The therapy incorporates and weaves together BBFM understanding of family patterns of interaction and physiological/medical concerns integrated with Bowenian intervention strategies. This case study validates the importance and usefulness of BBFM for intervention with stress-sensitive illnesses such as asthma. PMID:23148727

  1. Modeling Family Adaptation to Fragile X Syndrome

    ERIC Educational Resources Information Center

    Raspa, Melissa; Bailey, Donald, Jr.; Bann, Carla; Bishop, Ellen

    2014-01-01

    Using data from a survey of 1,099 families who have a child with Fragile X syndrome, we examined adaptation across 7 dimensions of family life: parenting knowledge, social support, social life, financial impact, well-being, quality of life, and overall impact. Results illustrate that although families report a high quality of life, they struggle…

  2. [Families and psychiatry: models and evolving links].

    PubMed

    Frankhauser, Adeline

    2016-01-01

    The role of the families of persons with severe psychiatric disorders (schizophrenia in particular) in the care of their relatives has recently evolved: once seen as pathogenic to be kept at a distance, the family is now recognised by professionals as a partner in the care process. The links between families and psychiatric institutions remain complex and marked by ambivalence and paradoxes. PMID:27157191

  3. A Versatile Family of Galactic Wind Models

    NASA Astrophysics Data System (ADS)

    Bustard, Chad; Zweibel, Ellen G.; D'Onghia, Elena

    2016-03-01

    We present a versatile family of model galactic outflows including non-uniform mass and energy source distributions, a gravitational potential from an extended mass source, and radiative losses. The model easily produces steady-state wind solutions for a range of mass-loading factors, energy-loading factors, galaxy mass, and galaxy radius. We find that, with radiative losses included, highly mass-loaded winds must be driven at high central temperatures, whereas low mass-loaded winds can be driven at low temperatures just above the peak of the cooling curve, meaning radiative losses can drastically affect the wind solution even for low mass-loading factors. By including radiative losses, we are able to show that subsonic flows can be ignored as a possible mechanism for expelling mass and energy from a galaxy compared to the more efficient transonic solutions. Specifically, the transonic solutions with low mass loading and high energy loading are the most efficient. Our model also produces low-temperature, high-velocity winds that could explain the prevalence of low-temperature material in observed outflows. Finally, we show that our model, unlike the well-known Chevalier & Clegg model, can reproduce the observed linear relationship between wind X-ray luminosity and star formation rate (SFR) over a large range of SFR from 1-1000 M⊙ yr-1 assuming the wind mass-loading factor is higher for low-mass, and hence, low-SFR galaxies. We also constrain the allowed mass-loading factors that can fit the observed X-ray luminosity versus SFR trend, further suggesting an inverse relationship between mass loading and SFR as explored in advanced numerical simulations.

  4. Calibration of Polytomous Item Families Using Bayesian Hierarchical Modeling

    ERIC Educational Resources Information Center

    Johnson, Matthew S.; Sinharay, Sandip

    2005-01-01

    For complex educational assessments, there is an increasing use of item families, which are groups of related items. Calibration or scoring in an assessment involving item families requires models that can take into account the dependence structure inherent among the items that belong to the same item family. This article extends earlier works in…

  5. A Conceptual Model Facilitating the Transition of Involuntary Migrant Families

    PubMed Central

    Samarasinghe, Kerstin Linnéa

    2011-01-01

    Refugee families face a complex transition due to the nature of involuntary migration and the process of acculturation. There are several risk factors to the family adaptation process during the transition period, which are sociocontextually environmental dependant. Facilitating a healthy transition for refugee families, therefore, requires the role of nursing to incorporate sociopolitics into the discipline. This paper introduces a sociopolitically oriented and community-driven assessment and intervention model which is based on a family systematic approach. Interventions that aid the families in their acculturation process as well as empowers them to a well-functioning daily life, as per the SARFI model, should be adopted. As such, the future of nursing may provide additional primary health care services for refugee families; this is through a team-led “family nurse” who provides quality care for the family unit in collaboration with other health care professionals and societal authorities. PMID:22191055

  6. Teaching English to Refugees: A Family Model.

    ERIC Educational Resources Information Center

    Andre, Elise; Brown, Dorothy S.

    The instructional program in English as a second language (ESL) followed by a family of 12 Hmong refugees in a small midwestern town is described. Eight of the younger members of the family met for one hour three times each week. Instruction was under the guidance of two teachers, thus allowing for individual help. Other volunteers assisted from…

  7. The Decker Family Development Center: Supportive Data of an Intervention Model for Multiple-Risk Families.

    ERIC Educational Resources Information Center

    Newman, Carole; And Others

    The Decker Family Development Center in Barberton (Ohio) is a holistic "one-stop shop" that provides services to families who are at multiple risk. During its 5 years of operation, this center has developed a model that goes beyond cooperation into co-construction to empower stakeholders. This paper describes the center and its successes and…

  8. A Family-Centered Model for Sharing Genetic Risk.

    PubMed

    Daly, Mary B

    2015-01-01

    The successes of the Human Genome Project have ushered in a new era of genomic science. To effectively translate these discoveries, it will be critical to improve the communication of genetic risk within families. This will require a systematic approach that accounts for the nature of family relationships and sociocultural beliefs. This paper proposes the application of the Family Systems Illness Model, used in the setting of cancer care, to the evolving field of genomics. PMID:26479564

  9. Legumes as a Model Plant Family

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The human population derives the majority of its nutrition either directly or indirectly (via animal protein) from two plant families: the grasses and the legumes. Grain legumes alone supply approximately 33% of human protein nutrition. Thus, it is critical for genetic improvement of legume crop spe...

  10. The biobehavioral and neuroimmune impact of low-dose ionizing radiation

    PubMed Central

    York, Jason M; Blevins, Neil A; Meling, Daryl D; Peterlin, Molly B; Gridley, Daila S; Cengel, Keith A; Freund, Gregory G

    2011-01-01

    In the clinical setting, repeated exposures (10–30) to low-doses of ionizing radiation (≤ 200 cGy), as seen in radiotherapy for cancer, causes fatigue. Almost nothing is known, however, about the fatigue inducing effects of a single exposure to environmental low-dose ionizing radiation that might occur during high-altitude commercial air flight, a nuclear reactor accident or a solar particle event (SPE). To investigate the short-term impact of low-dose ionizing radiation on mouse biobehaviors and neuroimmunity, male CD-1 mice were whole body irradiated with 50 cGy or 200 cGy of gamma or proton radiation. Gamma radiation was found to reduce spontaneous locomotor activity by 35% and 36%, respectively, 6 h post irradiation. In contrast, the motivated behavior of social exploration was un-impacted by gamma radiation. Examination of pro-inflammatory cytokine gene transcripts in the brain demonstrated that gamma radiation increased hippocampal TNF-α expression as early as 4 h post-irradiation. This was coupled to subsequent increases in IL-1RA (8 h and 12 h post irradiation) in the cortex and hippocampus and reductions in activity-regulated cytoskeleton-associated protein (Arc) (24 h post irradiation) in the cortex. Finally, restraint stress was a significant modulator of the neuroimmune response to radiation blocking the ability of 200 cGy gamma radiation from impairing locomotor activity and altering the brain-based inflammatory response to irradiation. Taken together, these findings indicate that low-dose ionizing radiation rapidly activates the neuroimmune system potentially causing early onset fatigue-like symptoms in mice. PMID:21958477

  11. The biobehavioral and neuroimmune impact of low-dose ionizing radiation.

    PubMed

    York, Jason M; Blevins, Neil A; Meling, Daryl D; Peterlin, Molly B; Gridley, Daila S; Cengel, Keith A; Freund, Gregory G

    2012-02-01

    In the clinical setting, repeated exposures (10-30) to low-doses of ionizing radiation (≤200 cGy), as seen in radiotherapy for cancer, causes fatigue. Almost nothing is known, however, about the fatigue inducing effects of a single exposure to environmental low-dose ionizing radiation that might occur during high-altitude commercial air flight, a nuclear reactor accident or a solar particle event (SPE). To investigate the short-term impact of low-dose ionizing radiation on mouse biobehaviors and neuroimmunity, male CD-1 mice were whole body irradiated with 50 cGy or 200 cGy of gamma or proton radiation. Gamma radiation was found to reduce spontaneous locomotor activity by 35% and 36%, respectively, 6 h post irradiation. In contrast, the motivated behavior of social exploration was un-impacted by gamma radiation. Examination of pro-inflammatory cytokine gene transcripts in the brain demonstrated that gamma radiation increased hippocampal TNF-α expression as early as 4 h post-irradiation. This was coupled to subsequent increases in IL-1RA (8 and 12 h post irradiation) in the cortex and hippocampus and reductions in activity-regulated cytoskeleton-associated protein (Arc) (24 h post irradiation) in the cortex. Finally, restraint stress was a significant modulator of the neuroimmune response to radiation blocking the ability of 200 cGy gamma radiation from impairing locomotor activity and altering the brain-based inflammatory response to irradiation. Taken together, these findings indicate that low-dose ionizing radiation rapidly activates the neuroimmune system potentially causing early onset fatigue-like symptoms in mice. PMID:21958477

  12. Biobehavioral Factors Mediate Exercise Effects on Fatigue in Breast Cancer Survivors

    PubMed Central

    Rogers, Laura Q; Vicari, Sandra; Trammell, Rita; Hopkins-Price, Patricia; Fogleman, Amanda; Spenner, Allison; Rao, Krishna; Courneya, Kerry S; Hoelzer, Karen S; Robbs, Randall; Verhulst, Steven

    2015-01-01

    Purpose Examine mediators of fatigue response to an exercise intervention for breast cancer survivors (BCS) in a pilot randomized controlled trial. Methods Postmenopausal BCS (n=46; ≤ Stage II), off primary treatment, and reporting fatigue and/or sleep dysfunction were randomized to a 3-month exercise intervention (160 minutes/week of moderate intensity aerobic walking, twice weekly resistance training with resistance bands) or control group. Six discussion group sessions provided behavioral support to improve adherence. Fatigue, serum cytokines, accelerometer physical activity, cardiorespiratory fitness, sleep dysfunction, and psychosocial factors were assessed at baseline and 3 months. Results Exercise intervention effect sizes for fatigue were: fatigue intensity d=0.30 (p=.34), interference d=−0.38 (p=.22), and general fatigue d=−0.49 (p=.13). Using Freedman-Schatzkin difference-in-coefficients tests, increase in fatigue intensity was significantly mediated by interleukin (IL)-6 (82%), IL-10 (94%), IL-6:IL-10 (49%), and tumor necrosis factor (TNF)-alpha:IL-10 (78%) with reduced sleep dysfunction increasing the relationship between intervention and fatigue intensity rather than mediating intervention effects (−88%). Decrease in fatigue interference was mediated by sleep dysfunction (35%) while IL-10 and pro:anti-inflammatory cytokine ratios increased the relationship between intervention and interference (−25% to −40%). The reduction in general fatigue was significantly mediated by minutes of physical activity (76%), sleep dysfunction (45%), and physical activity enjoyment (40%) with IL-10 (−40%) and IL-6:IL-10 (−11%) increasing the intervention-fatigue relationship. In the intervention group, higher baseline fatigue, anxiety, depression, and perceived exercise barriers interference predicted a greater decline in fatigue interference and/or general fatigue during the intervention. Conclusions Biobehavioral factors mediated and enhanced

  13. Psychosocial Telephone Counseling for Survivors of Cervical Cancer: Results of a Randomized Biobehavioral Trial

    PubMed Central

    Wenzel, Lari; Osann, Kathryn; Hsieh, Susie; Tucker, Jo A.; Monk, Bradley J.; Nelson, Edward L.

    2015-01-01

    Purpose Survivors of cervical cancer experience quality-of-life (QOL) disruptions that persist years after treatment. This study examines the effect of a psychosocial telephone counseling (PTC) intervention on QOL domains and associations with biomarkers. Patients and Methods We conducted a randomized clinical trial in survivors of cervical cancer, who were ≥ 9 and less than 30 months from diagnosis (n = 204), to compare PTC to usual care (UC). PTC included five weekly sessions and a 1-month booster. Patient-reported outcomes (PROs) and biospecimens were collected at baseline and 4 and 9 months after enrollment. Changes in PROs over time and associations with longitudinal change in cytokines as categorical variables were analyzed using multivariable analysis of variance for repeated measures. Results Participant mean age was 43 years; 40% of women were Hispanic, and 51% were non-Hispanic white. Adjusting for age and baseline scores, participants receiving PTC had significantly improved depression and improved gynecologic and cancer-specific concerns at 4 months compared with UC participants (all P < .05); significant differences in gynecologic and cancer-specific concerns (P < .05) were sustained at 9 months. Longitudinal change in overall QOL and anxiety did not reach statistical significance. Participants with decreasing interleukin (IL) -4, IL-5, IL-10, and IL-13 had significantly greater improvement in QOL than those with increasing cytokine levels. Conclusion This trial confirms that PTC benefits mood and QOL cancer-specific and gynecologic concerns for a multiethnic underserved population of survivors of cancer. The improvement in PROs with decreases in T-helper type 2 and counter-regulatory cytokines supports a potential biobehavioral pathway relevant to cancer survivorship. PMID:25713429

  14. Psycho-socioeconomic bio-behavioral associations on all-cause mortality: cohort study

    PubMed Central

    Loprinzi, Paul D.; Davis, Robert E.

    2016-01-01

    Background: The purpose of this study was to examine the cumulative effects of psychological,socioeconomic, biological and behavioral parameters on mortality. Methods: A prospective design was employed. Data from the 2005-2006 National Health and Nutrition Examination Survey (NHANES) were used (analyzed in 2015); follow-up mortality status evaluated in 2011. Psychological function was assessed from the Patient Health Questionnaire-9 (PHQ-9) as a measure of depression. Socioeconomic risk was assessed from poverty level, education, minority status, and social living status. Biological parameters included cholesterol, weight status, diabetes, hypertension and systemic inflammation. Behavioral parameters assessed included physical activity (accelerometry), dietary behavior, smoking status (cotinine) and sleep. These 14 psycho-socioeconomic bio-behavioral (PSBB) parameters allowed for the calculation of an overall PSBB Index, ranging from 0-14. Results: Among the evaluated 2530 participants, 161 died over the unweighted median follow-up period of 70.0 months. After adjustment, for every 1 increase in the overall PSBB index score,participants had a 15% reduced risk of all-cause mortality (HR = 0.85; 95% CI: 0.76-0.96). After adjustment, the Behavioral Index (HR = 0.73; 95% CI: 0.60-0.88) and the Socioeconomic Index(HR = 0.82; 95% CI: 0.68-0.99) were significant, but the Psychological Index (HR = 0.67; 95%CI: 0.29-1.51) and the Biological Index (HR = 1.03; 95% CI: 0.89-1.18) were not. Conclusion: Those with a worse PSBB score had an increased risk of all-cause mortality.Promotion of concurrent health behaviors may help to promote overall well-being and prolong survival. PMID:27386420

  15. Supporting Teachers, Strengthening Families: A Model Child Abuse Prevention Approach

    ERIC Educational Resources Information Center

    Olson, Maril

    2007-01-01

    This article talks about a model child abuse prevention approach called, "Supporting Teachers, Strengthening Families." It is NAEYC's professional development initiative to help early childhood educators play leading roles in preventing child abuse and neglect through family strengthening efforts. It focuses on six strategies that high-quality…

  16. Generalized Linear Models in Family Studies

    ERIC Educational Resources Information Center

    Wu, Zheng

    2005-01-01

    Generalized linear models (GLMs), as defined by J. A. Nelder and R. W. M. Wedderburn (1972), unify a class of regression models for categorical, discrete, and continuous response variables. As an extension of classical linear models, GLMs provide a common body of theory and methodology for some seemingly unrelated models and procedures, such as…

  17. Trials and tribulations of conducting bio-behavioral surveys in prisons: implementation science and lessons from Ukraine.

    PubMed

    Azbel, Lyuba; Grishaev, Yevgeny; Wickersham, Jeffrey A; Chernova, Olena; Dvoryak, Sergey; Polonsky, Maxim; Altice, Frederick L

    2016-06-13

    Purpose - Ukraine is home to Europe's worst HIV epidemic, overwhelmingly fueled by people who inject drugs who face harsh prison sentences. In Ukraine, HIV and other infectious diseases are concentrated in prisons, yet the magnitude of this problem had not been quantified. The purpose of this paper is to evaluate the systematic health survey of prisoners in the former Soviet Union (FSU). Design/methodology/approach - Qualitative interviews were carried out with research and prison administrative staff to assess the barriers and facilitators to conducting a bio-behavioral survey in Ukrainian prisons. Findings - Crucial barriers at the institutional, staff, and participant level require addressing by: first, ensuring Prison Department involvement at every stage; second, tackling pre-conceived attitudes about drug addiction and treatment among staff; and third, guaranteeing confidentiality for participants. Originality/value - The burden of many diseases is higher than expected and much higher than in the community. Notwithstanding the challenges, scientifically rigorous bio-behavioral surveys are attainable in criminal justice systems in the FSU with collaboration and careful consideration of this specific context. PMID:27219905

  18. Non-shock initiation model for explosive families : experimental results.

    SciTech Connect

    Anderson, Mark U.; Jensen, Charles B.; Todd, Steven N.; Hugh, Chance G.; Caipen, Terry L.

    2010-03-01

    The 'DaMaGe-Initiated-Reaction' (DMGIR) computational model has been developed to predict the response of high explosives to non-shock mechanical insults. The distinguishing feature of this model is the introduction of a damage variable, which relates the evolution of damage to the initiation of a reaction in the explosive, and its growth to detonation. Specifically designed experiments were used to study the initiation process of each explosive family with embedded shock sensors and optical diagnostics. The experimental portion of this model development began with a study of PBXN-5 to develop DMGIR model coefficients for the rigid plastic bonded family, followed by studies of the cast, and bulk-moldable explosive families. The experimental results show an initiation mechanism that is related to input energy and material damage, with well defined initiation thresholds for each explosive family. These initiation details will extend the predictive capability of the DMGIR model from the rigid family into the cast and bulk-moldable families.

  19. A Family of Rater Accuracy Models.

    PubMed

    Wolfe, Edward W; Jiao, Hong; Song, Tian

    2015-01-01

    Engelhard (1996) proposed a rater accuracy model (RAM) as a means of evaluating rater accuracy in rating data, but very little research exists to determine the efficacy of that model. The RAM requires a transformation of the raw score data to accuracy measures by comparing rater-assigned scores to true scores. Indices computed based on raw scores also exist for measuring rater effects, but these indices ignore deviations of rater-assigned scores from true scores. This paper demonstrates the efficacy of two versions of the RAM (based on dichotomized and polytomized deviations of rater-assigned scores from true scores) to two versions of raw score rater effect models (i.e., a Rasch partial credit model, PCM, and a Rasch rating scale model, RSM). Simulated data are used to demonstrate the efficacy with which these four models detect and differentiate three rater effects: severity, centrality, and inaccuracy. Results indicate that the RAMs are able to detect, but not differentiate, rater severity and inaccuracy, but not rater centrality. The PCM and RSM, on the other hand, are able to both detect and differentiate all three of these rater effects. However, the RSM and PCM do not take into account true scores and may, therefore, be misleading when pervasive trends exist in the rater-assigned data. PMID:26075664

  20. Adolescent Suicide-A Family Crisis: A Model for Effective Intervention by Family Therapists.

    ERIC Educational Resources Information Center

    Walker, Betty A.; Mehr, Marilyn

    1983-01-01

    Presents a model of crisis intervention counseling which outlines a professionally appropriate and realistic structure for effectively treating adolescent suicidal patients and their families. Discusses primary goals of the initial, intervention, and termination sessions which help adolescents communicate their emotional conflicts to their…

  1. Testing a model of family stress and coping based on war and non-war stressors, family resources and coping among Lebanese families.

    PubMed

    Farhood, L F

    1999-08-01

    This study was undertaken to describe the objective stressors, perceived stress, coping, and resources of families living in Beirut during the Lebanese war (1975-1991) and to test a model predicting the relationships of these variables to family adaptation. The sample consisted of 438 families chosen at random. Independent variables included objective stressors and perceived stress. The mediating variables were family resources and coping strategies. The dependent variables were health and interactional indicators of family adaptation: physical and psychological health, depression, and interpersonal and marital relationships. Findings provided support for the theoretical framework. Multiple regression analyses revealed that perceived stress, rather than the objective occurrence of events, predicted family adaptation. Family resources, particularly social support, positively impacted family adaptation and was associated with increased use of cognitive coping. The findings provide a theoretical model which, on further testing, can serve as a basis for practice by health professionals when working with traumatized families. PMID:10478497

  2. Life Skills Literacy: An Intervention Model to Alleviate Family Poverty

    ERIC Educational Resources Information Center

    Johnson, Lee N.; Carswell, Andrew T.; Palmer, Lance; Sweaney, Annie L.; Mullis, Rebecca M.; Leonas, Karen K.; Moss, Joan Koonce; Mauldin, Teresa

    2005-01-01

    Life Skills Literacy (LSL) is a multidisciplinary intervention model that helps families living with limited resources (including poverty) achieve sustainable well-being. This model, based on ecological theory and a readiness for change framework, prepares people to learn from the program and teaches necessary life skills. The LSL project…

  3. Skill-Based Management Training: The Teaching Family Model Revisisted.

    ERIC Educational Resources Information Center

    Baron, Richard L.; And Others

    This paper provides a description of the Program Manager Workshop, a skill-based management training workshop for managers of group homes. The workshop is an extension of the Teaching-Family Model of Community Based Care, a model used in residential treatment homes for persons experiencing problems such as delinquency, retardation, mental illness,…

  4. The family, crisis and chronic illness: an evolutionary model.

    PubMed

    Shaw, M C; Halliday, P H

    1992-05-01

    While chronic illness has a profound impact upon the individual, an immense burden is imposed upon the family. When the competing demands of an illness and the family escalate exponentially, there may be a crisis. Traditionally, crisis theory has been applied to acute care contexts such as emergency, intensive care and mental health nursing. Yet, clinical experience with families and chronic illness supports the notion of periodic crises from the prediagnostic phase to the long-haul of the illness. Moreover, the authors hypothesize that the family's perception of the event determines whether the crisis is perceived as a threat or a challenge. This paper thus addresses the perception of crisis within the framework of chronic illness from a biological and family systems nursing perspective. First, the theory of Humberto Maturana, a Chilean biologist, is explored and applied to clinical observations regarding family, crisis and chronic illness. Second, an evolutionary model for conceptualizing crisis and chronic illness is presented. Third, the role of beliefs in the family perceptions of crisis and chronic illness is discussed. PMID:1602067

  5. Frailty Models for Familial Risk with Application to Breast Cancer.

    PubMed

    Gorfine, Malka; Hsu, Li; Parmigiani, Giovanni

    2013-12-01

    In evaluating familial risk for disease we have two main statistical tasks: assessing the probability of carrying an inherited genetic mutation conferring higher risk; and predicting the absolute risk of developing diseases over time, for those individuals whose mutation status is known. Despite substantial progress, much remains unknown about the role of genetic and environmental risk factors, about the sources of variation in risk among families that carry high-risk mutations, and about the sources of familial aggregation beyond major Mendelian effects. These sources of heterogeneity contribute substantial variation in risk across families. In this paper we present simple and efficient methods for accounting for this variation in familial risk assessment. Our methods are based on frailty models. We implemented them in the context of generalizing Mendelian models of cancer risk, and compared our approaches to others that do not consider heterogeneity across families. Our extensive simulation study demonstrates that when predicting the risk of developing a disease over time conditional on carrier status, accounting for heterogeneity results in a substantial improvement in the area under the curve of the receiver operating characteristic. On the other hand, the improvement for carriership probability estimation is more limited. We illustrate the utility of the proposed approach through the analysis of BRCA1 and BRCA2 mutation carriers in the Washington Ashkenazi Kin-Cohort Study of Breast Cancer. PMID:24678132

  6. The Family-Study Interface and Academic Outcomes: Testing a Structural Model

    ERIC Educational Resources Information Center

    Meeuwisse, Marieke; Born, Marise Ph.; Severiens, Sabine E.

    2011-01-01

    Expanding on family-work and work-study models, this article investigated a model for family-study conflict and family-study facilitation. The focus of the study was the relationship of family-study conflict and family-study facilitation with students' effortful behaviors and academic performance among a sample of university students (N = 1,656).…

  7. Guide to Parent Involvement: Parents as Adult Learners. The Family Academy Model of the Family as Educator.

    ERIC Educational Resources Information Center

    American Univ., Washington, DC. Adult Learning Potential Inst.

    This document is the second of a series of four reports developed to provide a comprehensive overview of parent involvement, encompassing the family, parenting needs, and existing resources, in addition to current parent education approaches and practices. This "Family Academy Model" provides one interpretation of how the family functions as…

  8. Biobehavioral indices of emotion regulation relate to school attitudes, motivation, and behavior problems in a low-income preschool sample.

    PubMed

    Miller, Alison L; Seifer, Ronald; Stroud, Laura; Sheinkopf, Stephen J; Dickstein, Susan

    2006-12-01

    Effective emotion regulation may promote resilience and preschool classroom adjustment by supporting adaptive peer interactions and engagement in learning activities. We investigated how hypothalamus-pituitary-adrenal axis (HPA) regulation, cardiac reactivity, and classroom emotion displays related to adjustment among low-income preschoolers attending Head Start. A total of 62 four-year-olds completed a laboratory session including a baseline soothing video; emotion-eliciting slides/video clips, and recovery. Salivary cortisol, heart rate, and vagal tone were measured throughout. Independent coders used handheld computers to observe classroom emotion expression/regulation. Teachers rated child motivation, persistence/attention, learning attitudes, and internalizing/externalizing symptoms. Results reveal associations between biobehavioral markers of regulatory capacity and early school adjustment. PMID:17347370

  9. Applying ecological modeling to parenting for Australian refugee families.

    PubMed

    Grant, Julian; Guerin, Pauline B

    2014-10-01

    Children in families with parents from refugee backgrounds are often viewed as a vulnerable group with increased risks of developing physical or psychological problems. However, there is very little research regarding the strategies that parents might use to parent their children in a new country while they also manage the interrelated challenges of poverty, social isolation, maternal stress, and mental ill health that often go along with resettlement. We explore the application of ecological modeling, specifically at individual, institutional, and policy levels, within an Australian context to critique the factors that shape the development of parenting capacity within refugee families settling in a new Western country. Ecological modeling enables examination of how public policy at local state and national levels influences the individual and family directly and through the organizations that are given the task of implementing many of the policy recommendations. Recommendations for health practice and research are made. PMID:24583875

  10. Randomized crossover trial of kangaroo care to reduce biobehavioral pain responses in preterm infants: a pilot study.

    PubMed

    Cong, Xiaomei; Ludington-Hoe, Susan M; Walsh, Stephen

    2011-04-01

    Kangaroo care (KC), skin-to-skin contact between mother and infant, is a promising method for blunting pain responses. This crossover pilot tested KC effects on biobehavioral responses to heel stick in preterm infants (30-32 weeks' gestational age, 2-9 days old) measured by Premature Infant Pain Profile (PIPP) and salivary and serum cortisol. Mother-infant dyads were randomly assigned to KC heel stick (KCH) first or incubator heel stick (IH) first. Study 1 (80-min study, N = 18) tested the effect of 80 min of KC before and throughout the heel stick procedure versus incubator care. Study 2 (30-min study, N = 10) tested 30 min of KC before and throughout the heel stick versus incubator care. KCH and IH began during a premeasurement phase and continued through four data collection phases: baseline, heel warming, heel stick, and recovery. PIPP responses were measured every 30 s during data collection; salivary cortisol was measured at the end of baseline and recovery; and serum cortisol was measured during heel stick. Study 1 showed no differences between KCH and IH. Study 2 showed lower PIPP scores at four time points during recovery (p < .05 to p < .001), lower salivary cortisol at the end of recovery (p < .05), and lower serum cortisol during heel stick for the KCH condition (p < .05) as well as clinically lower PIPP scores in the KCH condition during heel stick. Thirty minutes of KC before and throughout the heel stick reduced biobehavioral responses to pain in preterm infants. PMID:21196428

  11. Work, Family, and Mental Health: Testing Different Models of Work-Family Fit.

    ERIC Educational Resources Information Center

    Grzywacz, Joseph G.; Bass, Brenda L.

    2003-01-01

    Using family resilience theory, this study examined the effects of work-family conflict and work-family facilitation on mental health among working adults to gain a better understanding of work-family fit. Results suggest that family to work facilitation is a family protective factor that offsets and buffers the deleterious effects of work-family…

  12. Three-family supersymmetric standardlike models from intersecting brane worlds.

    PubMed

    Cvetic, M; Shiu, G; Uranga, A M

    2001-11-12

    We construct the first three family N = 1 supersymmetric string model with standard model gauge group SU(3)(C) x SU(2)(L) x U(1)(Y) from an orientifold of type IIA theory on T(6)/(Z(2) x Z(2)) and D6-branes intersecting at angles. In addition to the minimal supersymmetric standard model particles, the model contains right-handed neutrinos, a chiral (but anomaly-free) set of exotic multiplets, and extra vectorlike multiplets. We discuss some phenomenological features of this model. PMID:11690462

  13. Toward a Wellness Model of Time-Effective Family Psychotherapy.

    ERIC Educational Resources Information Center

    Friedman, Steven

    1991-01-01

    Contends that psychologists need to appreciate the client's resources and strengths and avoid being coopted into a medical framework which skews one's thinking toward pathology and deficits. Describes a time-effective model of family psychotherapy which emphasizes possibilities, strengths, and resources. (Author/NB)

  14. Redistributing Wealth to Families: The Advantages of the MYRIADE Model

    ERIC Educational Resources Information Center

    Legendre, Francois; Lorgnet, Jean-Paul; Thibault, Florence

    2005-01-01

    This study aims to shed light on the main characteristics of the French system for redistributing wealth to families through tax revenues and social transfers. For the purposes of this exercise, the authors used the MYRIADE microsimulation model, which covers most of the redistribution system, though it is limited to monetary flows such as family…

  15. Treating Families of Demented Patients: Two Group Models.

    ERIC Educational Resources Information Center

    Kramer, Joel

    The prevalence of dementias in the elderly is steadily increasing. While caring for a dementing patient at home, families are subject to tremendous physical stresses and emotional reactions such as guilt, anger, grief, role confusion, depression, resentment, and loneliness. Two group treatment models addressing the mental health needs of…

  16. Designing Experiments to Discriminate Families of Logic Models.

    PubMed

    Videla, Santiago; Konokotina, Irina; Alexopoulos, Leonidas G; Saez-Rodriguez, Julio; Schaub, Torsten; Siegel, Anne; Guziolowski, Carito

    2015-01-01

    Logic models of signaling pathways are a promising way of building effective in silico functional models of a cell, in particular of signaling pathways. The automated learning of Boolean logic models describing signaling pathways can be achieved by training to phosphoproteomics data, which is particularly useful if it is measured upon different combinations of perturbations in a high-throughput fashion. However, in practice, the number and type of allowed perturbations are not exhaustive. Moreover, experimental data are unavoidably subjected to noise. As a result, the learning process results in a family of feasible logical networks rather than in a single model. This family is composed of logic models implementing different internal wirings for the system and therefore the predictions of experiments from this family may present a significant level of variability, and hence uncertainty. In this paper, we introduce a method based on Answer Set Programming to propose an optimal experimental design that aims to narrow down the variability (in terms of input-output behaviors) within families of logical models learned from experimental data. We study how the fitness with respect to the data can be improved after an optimal selection of signaling perturbations and how we learn optimal logic models with minimal number of experiments. The methods are applied on signaling pathways in human liver cells and phosphoproteomics experimental data. Using 25% of the experiments, we obtained logical models with fitness scores (mean square error) 15% close to the ones obtained using all experiments, illustrating the impact that our approach can have on the design of experiments for efficient model calibration. PMID:26389116

  17. A new, but old business model for family physicians: cash.

    PubMed

    Weber, J Michael

    2013-01-01

    The following study is an exploratory investigation into the opportunity identification, opportunity analysis, and strategic implications of implementing a cash-only family physician practice. The current market dynamics (i.e., increasing insurance premiums, decreasing benefits, more regulations and paperwork, and cuts in federal and state programs) suggest that there is sufficient motivation for these practitioners to change their current business model. In-depth interviews were conducted with office managers and physicians of family physician practices. The results highlighted a variety of issues, including barriers to change, strategy issues, and opportunities/benefits. The implications include theory applications, strategic marketing applications, and managerial decision-making. PMID:23924222

  18. Culture and Parenting: Family Models Are Not One-Size-Fits-All. FPG Snapshot #67

    ERIC Educational Resources Information Center

    FPG Child Development Institute, 2012

    2012-01-01

    Family process models guide theories and research about family functioning and child development outcomes. Theory and research, in turn, inform policies and services aimed at families. But are widely accepted models valid across cultural groups? To address these gaps, FPG researchers examined the utility of two family process models for families…

  19. Comparison of glycosyltransferase families using the profile hidden Markov model.

    PubMed

    Kikuchi, Norihiro; Kwon, Yeon-Dae; Gotoh, Masanori; Narimatsu, Hisashi

    2003-10-17

    In order to investigate the relationship between glycosyltransferase families and the motif for them, we classified 47 glycosyltransferase families in the CAZy database into four superfamilies, GTS-A, -B, -C, and -D, using a profile Hidden Markov Model method. On the basis of the classification and the similarity between GTS-A and nucleotidylyltransferase family catalyzing the synthesis of nucleotide-sugar, we proposed that ancient oligosaccharide might have been synthesized by the origin of GTS-B whereas the origin of GTS-A might be the gene encoding for synthesis of nucleotide-sugar as the donor and have evolved to glycosyltransferases to catalyze the synthesis of divergent carbohydrates. We also suggested that the divergent evolution of each superfamily in the corresponding subcellular component has increased the complexities of eukaryotic carbohydrate structure. PMID:14521949

  20. A family of models for Schelling binary choices

    NASA Astrophysics Data System (ADS)

    Cavalli, Fausto; Naimzada, Ahmad; Pireddu, Marina

    2016-02-01

    We introduce and study a family of discrete-time dynamical systems to model binary choices based on the framework proposed by Schelling in 1973. The model we propose uses a gradient-like adjustment mechanism by means of a family of smooth maps and allows understanding and analytically studying the phenomena qualitatively described by Schelling. In particular, we investigate existence of steady states and their relation to the equilibria of the static model studied by Schelling, and we analyze local stability, linking several examples and considerations provided by Schelling with bifurcation theory. We provide examples to confirm the theoretical results and to numerically investigate the possible destabilizations, as well as the emergence of coexisting attractors. We show the existence of chaos for a particular example.

  1. Graphical models of residue coupling in protein families.

    PubMed

    Thomas, John; Ramakrishnan, Naren; Bailey-Kellogg, Chris

    2008-01-01

    Many statistical measures and algorithmic techniques have been proposed for studying residue coupling in protein families. Generally speaking, two residue positions are considered coupled if, in the sequence record, some of their amino acid type combinations are significantly more common than others. While the proposed approaches have proven useful in finding and describing coupling, a significant missing component is a formal probabilistic model that explicates and compactly represents the coupling, integrates information about sequence,structure, and function, and supports inferential procedures for analysis, diagnosis, and prediction.We present an approach to learning and using probabilistic graphical models of residue coupling. These models capture significant conservation and coupling constraints observable ina multiply-aligned set of sequences. Our approach can place a structural prior on considered couplings, so that all identified relationships have direct mechanistic explanations. It can also incorporate information about functional classes, and thereby learn a differential graphical model that distinguishes constraints common to all classes from those unique to individual classes. Such differential models separately account for class-specific conservation and family-wide coupling, two different sources of sequence covariation. They are then able to perform interpretable functional classification of new sequences, explaining classification decisions in terms of the underlying conservation and coupling constraints. We apply our approach in studies of both G protein-coupled receptors and PDZ domains, identifying and analyzing family-wide and class-specific constraints, and performing functional classification. The results demonstrate that graphical models of residue coupling provide a powerful tool for uncovering, representing, and utilizing significant sequence structure-function relationships in protein families. PMID:18451428

  2. Exponential-family random graph models for valued networks

    PubMed Central

    Krivitsky, Pavel N.

    2013-01-01

    Exponential-family random graph models (ERGMs) provide a principled and flexible way to model and simulate features common in social networks, such as propensities for homophily, mutuality, and friend-of-a-friend triad closure, through choice of model terms (sufficient statistics). However, those ERGMs modeling the more complex features have, to date, been limited to binary data: presence or absence of ties. Thus, analysis of valued networks, such as those where counts, measurements, or ranks are observed, has necessitated dichotomizing them, losing information and introducing biases. In this work, we generalize ERGMs to valued networks. Focusing on modeling counts, we formulate an ERGM for networks whose ties are counts and discuss issues that arise when moving beyond the binary case. We introduce model terms that generalize and model common social network features for such data and apply these methods to a network dataset whose values are counts of interactions. PMID:24678374

  3. Fourth standard model family neutrino at future linear colliders

    SciTech Connect

    Ciftci, A.K.; Ciftci, R.; Sultansoy, S.

    2005-09-01

    It is known that flavor democracy favors the existence of the fourth standard model (SM) family. In order to give nonzero masses for the first three-family fermions flavor democracy has to be slightly broken. A parametrization for democracy breaking, which gives the correct values for fundamental fermion masses and, at the same time, predicts quark and lepton Cabibbo-Kobayashi-Maskawa (CKM) matrices in a good agreement with the experimental data, is proposed. The pair productions of the fourth SM family Dirac ({nu}{sub 4}) and Majorana (N{sub 1}) neutrinos at future linear colliders with {radical}(s)=500 GeV, 1 TeV, and 3 TeV are considered. The cross section for the process e{sup +}e{sup -}{yields}{nu}{sub 4}{nu}{sub 4}(N{sub 1}N{sub 1}) and the branching ratios for possible decay modes of the both neutrinos are determined. The decays of the fourth family neutrinos into muon channels ({nu}{sub 4}(N{sub 1}){yields}{mu}{sup {+-}}W{sup {+-}}) provide cleanest signature at e{sup +}e{sup -} colliders. Meanwhile, in our parametrization this channel is dominant. W bosons produced in decays of the fourth family neutrinos will be seen in detector as either di-jets or isolated leptons. As an example, we consider the production of 200 GeV mass fourth family neutrinos at {radical}(s)=500 GeV linear colliders by taking into account di-muon plus four jet events as signatures.

  4. A Network Synthesis Model for Generating Protein Interaction Network Families

    PubMed Central

    Sahraeian, Sayed Mohammad Ebrahim; Yoon, Byung-Jun

    2012-01-01

    In this work, we introduce a novel network synthesis model that can generate families of evolutionarily related synthetic protein–protein interaction (PPI) networks. Given an ancestral network, the proposed model generates the network family according to a hypothetical phylogenetic tree, where the descendant networks are obtained through duplication and divergence of their ancestors, followed by network growth using network evolution models. We demonstrate that this network synthesis model can effectively create synthetic networks whose internal and cross-network properties closely resemble those of real PPI networks. The proposed model can serve as an effective framework for generating comprehensive benchmark datasets that can be used for reliable performance assessment of comparative network analysis algorithms. Using this model, we constructed a large-scale network alignment benchmark, called NAPAbench, and evaluated the performance of several representative network alignment algorithms. Our analysis clearly shows the relative performance of the leading network algorithms, with their respective advantages and disadvantages. The algorithm and source code of the network synthesis model and the network alignment benchmark NAPAbench are publicly available at http://www.ece.tamu.edu/bjyoon/NAPAbench/. PMID:22912671

  5. Disaster Hits Home: A Model of Displaced Family Adjustment after Hurricane Katrina

    ERIC Educational Resources Information Center

    Peek, Lori; Morrissey, Bridget; Marlatt, Holly

    2011-01-01

    The authors explored individual and family adjustment processes among parents (n = 30) and children (n = 55) who were displaced to Colorado after Hurricane Katrina. Drawing on in-depth interviews with 23 families, this article offers an inductive model of displaced family adjustment. Four stages of family adjustment are presented in the model: (a)…

  6. Solution-focused therapy. Counseling model for busy family physicians.

    PubMed Central

    Greenberg, G.; Ganshorn, K.; Danilkewich, A.

    2001-01-01

    OBJECTIVE: To provide family doctors in busy office practices with a model for counseling compatible with patient-centred medicine, including the techniques, strategies, and questions necessary for implementation. QUALITY OF EVIDENCE: The MEDLINE database was searched from 1984 to 1999 using the terms psychotherapy in family practice, brief therapy in family practice, solution-focused therapy, and brief psychotherapy. A total of 170 relevant articles were identified; 75 abstracts were retrieved and a similar number of articles read. Additional resources included seminal books on solution-focused therapy (SFT), bibliographies of salient articles, participation in workshops on SFT, and observation of SFT counseling sessions taped by leaders in the field. MAIN MESSAGE: Solution-focused therapy's concentration on collaborative identification and amplification of patient strengths is the foundation upon which solutions to an array of problems are built. Solution-focused therapy offers simplicity, practicality, and relative ease of application. From the perspective of a new learner, MECSTAT provides a framework that facilitates development of skills. CONCLUSION: Solution-focused therapy recognizes that, even in the bleakest of circumstances, an emphasis on individual strength is empowering. In recognizing patients as experts in self-care, family physicians support and accentuate patient-driven change, and in so doing, are freed from the hopelessness and burnout that can accompany misplaced feelings of responsibility. PMID:11768927

  7. Family Members Affected by a Close Relative's Addiction: The Stress-Strain-Coping-Support Model

    ERIC Educational Resources Information Center

    Orford, Jim; Copello, Alex; Velleman, Richard; Templeton, Lorna

    2010-01-01

    This article outlines the stress-strain-coping-support (SSCS) model which underpins the whole programme of work described in this supplement. The need for such a model is explained: previous models of substance misuse and the family have attributed dysfunction or deficiency to families or family members. In contrast, the SSCS model assumes that…

  8. Towards a Family Process Model of Maternal and Paternal Depressive Symptoms: Exploring Multiple Relations with Child and Family Functioning

    ERIC Educational Resources Information Center

    Cummings, E. Mark; Keller, Peggy S.; Davies, Patrick T.

    2005-01-01

    Background: Research has focused on maternal dysphoria and child adjustment. However, family process models indicate gaps in the study of paternal dysphoria, broader family functioning, and diverse child outcomes. Method: A community sample of 235 mothers and fathers of kindergarten children completed measures of depressive symptoms, family…

  9. Shape modeling with family of Pearson distributions: Langmuir waves

    NASA Astrophysics Data System (ADS)

    Vidojevic, Sonja

    2014-10-01

    Two major effects of Langmuir wave electric field influence on spectral line shapes are appearance of depressions shifted from unperturbed line and an additional dynamical line broadening. More realistic and accurate models of Langmuir waves are needed to study these effects with more confidence. In this article we present distribution shapes of a high-quality data set of Langmuir waves electric field observed by the WIND satellite. Using well developed numerical techniques, the distributions of the empirical measurements are modeled by family of Pearson distributions. The results suggest that the existing theoretical models of energy conversion between an electron beam and surrounding plasma is more complex. If the processes of the Langmuir wave generation are better understood, the influence of Langmuir waves on spectral line shapes could be modeled better.

  10. Modeling spatial accessibility of immigrants to culturally diverse family physicians.

    PubMed

    Wanga, Lu; Roisman, Deborah

    2011-01-01

    This article uses accessibility as an analytical tool to examine health care access among immigrants in a multicultural urban setting. It applies and improves on two widely used accessibility models—the gravity model and the two-step floating catchment area model—in measuring spatial accessibility by Mainland Chinese immigrants in the Toronto Census Metropolitan Area. Empirical data on physician-seeking behaviors are collected through two rounds of questionnaire surveys. Attention is focused on journey to physician location and utilization of linguistically matched family physicians. Based on the survey data, a two-zone accessibility model is developed by relaxing the travel threshold and distance impedance parameters that are traditionally treated as a constant in the accessibility models. General linear models are used to identify relationships among spatial accessibility, geography, and socioeconomic characteristics of Mainland Chinese immigrants. The results suggest a spatial mismatch in the supply of and demand for culturally sensitive care, and residential location is the primary factor that determines spatial accessibility to family physicians. The article yields important policy implications. PMID:21488318

  11. Multimodal Physiotherapy Based on a Biobehavioral Approach as a Treatment for Chronic Tension-Type Headache: A Case Report

    PubMed Central

    Beltran-Alacreu, Hector; Lopez-de-Uralde-Villanueva, Ibai; La Touche, Roy

    2015-01-01

    Introduction: Tension-type headache (TTH) is the most common primary headache affecting the general population, which is characterized by bilateral headache and mild to moderate pain. This disorder causes high levels of disability and recent scientific evidence suggests that manual therapy (MT) and therapeutic exercise are effective in reducing medication intake and decreasing the frequency and intensity of headaches in patients with TTH. Case Presentation: A 34-year-old woman was known to have chronic TTH. Initially, the patient presented moderate headaches 5 days per week, mechanical neck pain and no positive response to analgesics. A battery of self-reports was given to the patient to assess disability (using the Spanish versions of the Headache Impact Test-6 and the neck disability index), pain (visual analogue scale) and psychosocial issues (Spanish version of the pain catastrophizing scale) involved in the headaches. All measurements were taken four times during 161 days. Eleven sessions of treatment including MT, motor control therapeutic exercise (MCTE) and therapeutic patient education (TPE) were applied. Conclusions: This biobehavioral-based multimodal physical rehabilitation treatment combining MT, TPE and MCTE produced a substantial reduction in pain intensity, pain catastrophizing, disability and the impact of headaches on patient’s life. PMID:26705532

  12. Biobehavioral consequences of prenatal exposure to a matrilineal overthrow and relocation in captive infant rhesus (Macaca mulatta) monkeys.

    PubMed

    Herrington, Joshua A; Del Rosso, Laura A; Capitanio, John P

    2016-09-01

    There is a general consensus that perinatal experiences help to shape infant behavior; however, relatively little is known about the effects of prenatal experience on postnatal phenotype in non-human primates. The current study sought to take advantage of a naturally occurring incident in a captive population of rhesus monkeys. Following a matrilineal overthrow in an outdoor field cage, pregnant female rhesus macaques were relocated from outdoor to indoor housing. Using data collected from the California National Primate Research Center's Biobehavioral Assessment Program, we assessed infants born to mothers that were in their first or second trimester of pregnancy during the overthrow and relocation, and compared their data with that of animals from two control groups born in the same year: indoor mother raised infants and field cage reared infants. Our results suggest that the experience of an overthrow and relocation during the first trimester elevated postnatal emotional responsiveness, while the same experience in the second trimester resulted in modified HPA axis regulation, elevated glucocorticoid output following maternal separation, and lower hematocrit levels compared to control groups. These data add to a growing body of literature that prenatal experiences represent a significant contribution to postnatal phenotypic variability. Findings such as ours have implications for studies in captive management and the management of captive rhesus monkey populations. Am. J. Primatol. 78:895-903, 2016. © 2016 Wiley Periodicals, Inc. PMID:27150125

  13. Youth Depression in the Family Context: Familial Risk Factors and Models of Treatment

    ERIC Educational Resources Information Center

    Sander, Janay B.; McCarty, Carolyn A.

    2005-01-01

    Research on parent risk factors, family environment, and familial involvement in the treatment of depression in children and adolescents is integrated, providing an update to prior reviews on the topic. First, the psychosocial parent and family factors associated with youth depression are examined. The literature indicates that a broad array of…

  14. A family of dynamic models for large-eddy simulation

    NASA Technical Reports Server (NTRS)

    Carati, D.; Jansen, K.; Lund, T.

    1995-01-01

    Since its first application, the dynamic procedure has been recognized as an effective means to compute rather than prescribe the unknown coefficients that appear in a subgrid-scale model for Large-Eddy Simulation (LES). The dynamic procedure is usually used to determine the nondimensional coefficient in the Smagorinsky (1963) model. In reality the procedure is quite general and it is not limited to the Smagorinsky model by any theoretical or practical constraints. The purpose of this note is to consider a generalized family of dynamic eddy viscosity models that do not necessarily rely on the local equilibrium assumption built into the Smagorinsky model. By invoking an inertial range assumption, it will be shown that the coefficients in the new models need not be nondimensional. This additional degree of freedom allows the use of models that are scaled on traditionally unknown quantities such as the dissipation rate. In certain cases, the dynamic models with dimensional coefficients are simpler to implement, and allow for a 30% reduction in the number of required filtering operations.

  15. Three family GUT-like models from heterotic string

    SciTech Connect

    Takahashi, Kei-Jiro

    2008-05-13

    We construct three-family SU(5) and SO(10) GUT-like models, based on an orbifold in the E{sub 8}xE{sub 8} heterotic string theory [28]. We recently classified orbifolds on the E{sub 6} root lattice. Interestingly, we found that some of the twisted sectors from the Z{sub 3}xZ{sub 3} orbifold on the E{sub 6} root lattice have just three fixed tori respectively, and it leads to three degenerate massless states. These models also include strongly coupled sectors in the low energy and messenger states charged with both hidden and visible sectors. We present the massless spectra of the models, and consider their interactions.

  16. Putting theory to the test: Examining family context, caregiver motivation, and conflict in the Family Check-Up model

    PubMed Central

    Fosco, Gregory M.; Van Ryzin, Mark; Stormshak, Elizabeth A.; Dishion, Thomas J.

    2014-01-01

    This study examined contextual factors (caregiver depression, family resources, ethnicity, and initial levels of youth problem behavior) related to the effectiveness of the Family Check-Up (FCU) and evaluated family processes as a mediator of FCU intervention response and adolescent antisocial behavior. We followed a sample of 180 ethnically diverse youths of families who engaged in the FCU intervention. Family data were collected as part of the FCU assessment, and youth data were collected over 4 years, from sixth through ninth grade. Findings indicated that caregiver depression and minority status predicted greater caregiver motivation to change. In turn, caregiver motivation was the only direct predictor of FCU intervention response during a 1-year period. Growth in family conflict from sixth through eighth grade mediated the link between FCU response and ninth-grade antisocial behavior. This study explicitly tested core aspects of the FCU intervention model and demonstrated that caregiver motivation is a central factor that underlies family response to the FCU. The study also provided support for continued examination of family process mechanisms that account for enduring effects of the FCU and other family-centered interventions. PMID:24438894

  17. Putting theory to the test: examining family context, caregiver motivation, and conflict in the Family Check-Up model.

    PubMed

    Fosco, Gregory M; Van Ryzin, Mark; Stormshak, Elizabeth A; Dishion, Thomas J

    2014-05-01

    This study examined contextual factors (caregiver depression, family resources, ethnicity, and initial levels of youth problem behavior) related to the effectiveness of the Family Check-Up (FCU) and evaluated family processes as a mediator of FCU intervention response and adolescent antisocial behavior. We followed a sample of 180 ethnically diverse youths of families who engaged in the FCU intervention. Family data were collected as part of the FCU assessment, and youth data were collected over 4 years, from sixth through ninth grade. Findings indicated that caregiver depression and minority status predicted greater caregiver motivation to change. In turn, caregiver motivation was the only direct predictor of FCU intervention response during a 1-year period. Growth in family conflict from sixth through eighth grade mediated the link between FCU response and ninth-grade antisocial behavior. This study explicitly tested core aspects of the FCU intervention model and demonstrated that caregiver motivation is a central factor that underlies family response to the FCU. The study also provided support for continued examination of family process mechanisms that account for enduring effects of the FCU and other family-centered interventions. PMID:24438894

  18. Even Start Family Literacy Program Evaluation, Oklahoma City Public Schools: A National Diffusion Network Approved Program, Family Intergenerational-Interaction Literacy Model 1993-94.

    ERIC Educational Resources Information Center

    Oklahoma City Univ., OK.

    The Even Start Family Literacy Program, in its fourth year of operation, provides a literacy environment based on the Family Intergenerational-Interaction Literacy Model (FILM) in the southwest area of Oklahoma City. The FILM model is designed to provide a family literacy education program for parents, extended family, and their preschool children…

  19. Creating Better Family Child Care Jobs: Model Work Standards.

    ERIC Educational Resources Information Center

    Haack, Peggy

    Based on the premise that good child care jobs are the cornerstone of high-quality services for children and families, this booklet details workplace standards for family child care providers. The booklet is designed to be used for educating family child care providers, evaluating individual family child care programs, setting goals and measuring…

  20. Family support and acceptance, gay male identity formation, and psychological adjustment: a path model.

    PubMed

    Elizur, Y; Ziv, M

    2001-01-01

    While heterosexist family undermining has been demonstrated to be a developmental risk factor in the life of persons with same-gender orientation, the issue of protective family factors is both controversial and relatively neglected. In this study of Israeli gay males (N = 114), we focused on the interrelations of family support, family acceptance and family knowledge of gay orientation, and gay male identity formation, and their effects on mental health and self-esteem. A path model was proposed based on the hypotheses that family support, family acceptance, family knowledge, and gay identity formation have an impact on psychological adjustment, and that family support has an effect on gay identity formation that is mediated by family acceptance. The assessment of gay identity formation was based on an established stage model that was streamlined for cross-cultural practice by defining three basic processes of same-gender identity formation: self-definition, self-acceptance, and disclosure (Elizur & Mintzer, 2001). The testing of our conceptual path model demonstrated an excellent fit with the data. An alternative model that hypothesized effects of gay male identity on family acceptance and family knowledge did not fit the data. Interpreting these results, we propose that the main effect of family support/acceptance on gay identity is related to the process of disclosure, and that both general family support and family acceptance of same-gender orientation play a significant role in the psychological adjustment of gay men. PMID:11444052

  1. Three-family unification in higher dimensional models

    SciTech Connect

    Mimura, Yukihiro; Nandi, S.

    2009-05-01

    In orbifold models, gauge, Higgs, and the matter fields can be unified in one multiplet from the compactification of higher dimensional supersymmetric gauge theory. We study how three families of chiral fermions can be unified in the gauge multiplet. The bulk gauge interaction includes the Yukawa interactions to generate masses for quarks and leptons after the electroweak symmetry is broken. The bulk Yukawa interaction has global or gauged flavor symmetry originating from the R symmetry or bulk gauge symmetry, and the Yukawa structure is restricted. When the global and gauged flavor symmetries are broken by orbifold compactification, the remaining gauge symmetry which contains the standard model gauge symmetry is restricted. The restrictions from the bulk flavor symmetries can provide explanations of fermion mass hierarchy.

  2. Evaluation of the Stress Adjustment and Adaptation Model among Families Reporting Economic Pressure

    ERIC Educational Resources Information Center

    Vandsburger, Etty; Biggerstaff, Marilyn A.

    2004-01-01

    This research evaluates the Stress Adjustment and Adaptation Model (double ABCX model) examining the effects resiliency resources on family functioning when families experience economic pressure. Families (N = 128) with incomes at or below the poverty line from a rural area of a southern state completed measures of perceived economic pressure,…

  3. Economic Crisis and Marital Problems in Turkey: Testing the Family Stress Model

    ERIC Educational Resources Information Center

    Aytac, Isik A.; Rankin, Bruce H.

    2009-01-01

    This paper applied the family stress model to the case of Turkey in the wake of the 2001 economic crisis. Using structural equation modeling and a nationally representative urban sample of 711 married women and 490 married men, we tested whether economic hardship and the associated family economic strain on families resulted in greater marital…

  4. Applying the Post-Modern Double ABC-X Model to Family Food Insecurity

    ERIC Educational Resources Information Center

    Hutson, Samantha; Anderson, Melinda; Swafford, Melinda

    2015-01-01

    This paper develops the argument that using the Double ABC-X model in family and consumer sciences (FCS) curricula is a way to educate nutrition and dietetics students regarding a family's perceptions of food insecurity. The Double ABC-X model incorporates ecological theory as a basis to explain family stress and the resulting adjustment and…

  5. Graded Response Model Based on the Logistic Positive Exponent Family of Models for Dichotomous Responses

    ERIC Educational Resources Information Center

    Samejima, Fumiko

    2008-01-01

    Samejima ("Psychometrika "65:319--335, 2000) proposed the logistic positive exponent family of models (LPEF) for dichotomous responses in the unidimensional latent space. The objective of the present paper is to propose and discuss a graded response model that is expanded from the LPEF, in the context of item response theory (IRT). This specific…

  6. Parallel family trees for transfer matrices in the Potts model

    NASA Astrophysics Data System (ADS)

    Navarro, Cristobal A.; Canfora, Fabrizio; Hitschfeld, Nancy; Navarro, Gonzalo

    2015-02-01

    The computational cost of transfer matrix methods for the Potts model is related to the question in how many ways can two layers of a lattice be connected? Answering the question leads to the generation of a combinatorial set of lattice configurations. This set defines the configuration space of the problem, and the smaller it is, the faster the transfer matrix can be computed. The configuration space of generic (q , v) transfer matrix methods for strips is in the order of the Catalan numbers, which grows asymptotically as O(4m) where m is the width of the strip. Other transfer matrix methods with a smaller configuration space indeed exist but they make assumptions on the temperature, number of spin states, or restrict the structure of the lattice. In this paper we propose a parallel algorithm that uses a sub-Catalan configuration space of O(3m) to build the generic (q , v) transfer matrix in a compressed form. The improvement is achieved by grouping the original set of Catalan configurations into a forest of family trees, in such a way that the solution to the problem is now computed by solving the root node of each family. As a result, the algorithm becomes exponentially faster than the Catalan approach while still highly parallel. The resulting matrix is stored in a compressed form using O(3m ×4m) of space, making numerical evaluation and decompression to be faster than evaluating the matrix in its O(4m ×4m) uncompressed form. Experimental results for different sizes of strip lattices show that the parallel family trees (PFT) strategy indeed runs exponentially faster than the Catalan Parallel Method (CPM), especially when dealing with dense transfer matrices. In terms of parallel performance, we report strong-scaling speedups of up to 5.7 × when running on an 8-core shared memory machine and 28 × for a 32-core cluster. The best balance of speedup and efficiency for the multi-core machine was achieved when using p = 4 processors, while for the cluster

  7. Family, Infant, and Toddler (FIT) Guide. A Model for Rural Family-Implemented Educational Programs.

    ERIC Educational Resources Information Center

    Carr, Ann B., Ed.; And Others

    The manual describes the Family, Infant, and Toddler Project for rural handicapped preschoolers and their families. The project, based on an ecological perspective, has three goals: to develop a demonstration service program, to increase the pool of qualified personnel, and to expand educational services to preschool aged mentally retarded…

  8. Learning from e-Family History: A Model of Online Family Historian Research Behaviour

    ERIC Educational Resources Information Center

    Friday, Kate

    2014-01-01

    Introduction: This paper reports on doctoral research which investigated the online research behaviour of family historians, from the overall perspective of local studies collections and developing online services for family historians. Method: A hybrid (primarily ethnographic) study was employed using qualitative diaries and shadowing, to examine…

  9. [The comparative study on parent-adolescent communication between the model student family and the delinquent adolescent family].

    PubMed

    Kim, Y H; Shin, H S

    1990-12-31

    This research is based on the communication system theory which considers the family as a communication system or a communication network and which understand interpersonal relations among family members through a communication. This research is intended to define the difference of Parent-Adolescent Child communication between the model student family and the delinquent adolescent family, and also found the factors affecting parent-adolescent child communication. This aims to clarify wether a delinquent behavior is associated with family members' relations caused by dysfunctional communication between parents and their child, moreover explorate their problem to find the method of nursing intervention for prevention and treatment for delinquency. Subjects are 190 families (570 persons: father, mother, adolescent child) of model high school students and 87 families (261 persons) of delinquent adolescents. The employed tool is Olson et al's Parent-Adolescent Communication Scale (PAC, 20 items). The followings are the results derived through hypotheses verification. First, Comparison of two groups showed a significant difference in Parent-Adolescent Communication (t = 2.77, p less than 0.1). In the communication of delinquent group showed lower response than the model group. And also communication of the model group was more opened and positive (t = 2.41, p less than .05), and showed fewer problems (t = 2.06, p less than .05), the delinquent group had more problems. 2ndary, the delinquent group showed significantly more disagreement in response to variable of PAC than the model group. As analyzing of factors affects the Parents-Adolescent Communication, the best method to protect juvenile from delinquency are consistent open-hearted, congruent communication with mutual concern and warm mind between parents and child. And even though the all family don't hardly send together their time for their job, parents have to arrange many times to hold communication with children

  10. Family socioeconomic status, family health, and changes in students' math achievement across high school: A mediational model.

    PubMed

    Barr, Ashley Brooke

    2015-09-01

    In response to recent calls to integrate understandings of socioeconomic disparities in health with understandings of socioeconomic disparities in academic achievement, this study tested a mediational model whereby family socioeconomic status predicted gains in academic achievement across high school through its impact on both student and parent health. Data on over 8000 high school students in the U.S. were obtained from wave 1 (2009-2010) and wave 2 (2012) of the High School Longitudinal Study of 2009 (HSLS:09), and structural equation modeling with latent difference scores was used to determine the role of family health problems in mediating the well-established link between family SES and gains in academic achievement. Using both static and dynamic indicators of family SES, support was found for this mediational model. Higher family SES in 9th grade reduced the probability of students and their parents experiencing a serious health problem in high school, thereby promoting growth in academic achievement. In addition, parent and student health problems mediated the effect of changes in family SES across high school on math achievement gains. Results emphasize the importance of considering the dynamic nature of SES and that both student and parent health should be considered in understanding SES-related disparities in academic achievement. This relational process provides new mechanisms for understanding the intergenerational transmission of socioeconomic status and the status attainment process more broadly. PMID:26189011

  11. Growth mixture modelling in families of the Framingham Heart Study

    PubMed Central

    2009-01-01

    Growth mixture modelling, a less explored method in genetic research, addresses unobserved heterogeneity in population samples. We applied this technique to longitudinal data of the Framingham Heart Study. We examined systolic blood pressure (BP) measures in 1060 males from 692 families and detected three subclasses, which varied significantly in their developmental trajectories over time. The first class consisted of 60 high-risk individuals with elevated BP early in life and a steep increase over time. The second group of 131 individuals displayed first normal BP, but showed a significant increase over time and reached high BP values late in their life time. The largest group of 869 individuals could be considered a normative group with normal BP on all exams. To identify genetic modulators for this phenotype, we tested 2,340 single-nucleotide polymorphisms on chromosome 8 for association with the class membership probabilities of our model. The probability of being in Class 1 was significantly associated with a very rare variant (rs1445404) present in only four individuals from four different families located in the coding region of the gene EYA (eyes absent homolog 1 in Drosophila) (p = 1.39 × 10-13). Mutations in EYA are known to cause brachio-oto-renal syndrome, as well as isolated renal malformations. Renal malformations could cause high BP early in life. This result awaits replication; however, it suggests that analyzing genetic data stratified for high-risk subgroups defined by a unique development over time could be useful for the detection of rare mutations in common multi-factorial diseases. PMID:20017979

  12. Validating the Relationship Qualities of Influence and Persuasion with the Family Social Relations Model.

    ERIC Educational Resources Information Center

    Hsiung, Rachel Oakley; Bagozzi, Richard P.

    2003-01-01

    Uses the family social relations model (SRM) to test for the personal relationship qualities of influence and persuasion in the family decision-making context of buying a new car. Uncovers patterns in the relationship qualities of influence and persuasion across three decisions families make when buying a new car (i.e., how much to spend, car…

  13. Relations between Minuchin's Structural Family Model and Kohut's Self-Psychology Constructs.

    ERIC Educational Resources Information Center

    Perosa, Linda

    1996-01-01

    Examines relationship between structural family model and self-psychology constructs. College women (n=164) completed the Structural Family Interaction Scale-Revised (SFIS-R), the Parental Relations Inventory, and the Goal Instability and Superiority scales from the Self-Expression Inventory. Indicated that women raised in families with strong…

  14. Integrating Gender on Multiple Levels: A Conceptual Model for Teaching Gender Issues in Family Therapy

    ERIC Educational Resources Information Center

    Williams, Lee; McBain, Heidi

    2006-01-01

    As the field of family therapy has evolved, there has been growing recognition as to the importance of gender in family therapy. To prepare the next generation of family therapists adequately, it is important that they recognize the many and complex ways in which gender permeates their work. In this article we present an integrative model to help…

  15. Testing a Mediational Model of Communication Among Medical Staff and Families of Cancer Patients

    ERIC Educational Resources Information Center

    Gionta, Dana A.; Harlow, Lisa L.; Loitman, Jane E.; Leeman, Joanne M.

    2005-01-01

    Three structural equation models of communication between family members and medical staff were examined to understand relations among staff accessibility, inhibitory family attitudes, getting communication needs met, perceived stress, and satisfaction with communication. Compared to full and direct models, a mediational model fit best in which…

  16. Dynamic Processes in Regulation and Some Implications for Biofeedback and Biobehavioral Interventions

    PubMed Central

    Lehrer, Paul; Eddie, David

    2013-01-01

    Systems theory has long been applied in psychology, biology, and sociology. This paper applies newer methods of control systems modeling to the assessment of system stability in health and disease. Control systems can be characterized as open or closed systems with feedback loops. Feedback produces oscillatory activity, and the complexity of naturally occurring oscillatory patterns reflects the multiplicity of feedback mechanisms, such that many mechanisms operate simultaneously to control the system. Unstable systems, often associated with poor health, are characterized by absence of oscillation, random noise, or a very simple pattern of oscillation. This modeling approach can be applied to a diverse range of phenomena, including cardiovascular and brain activity, mood and thermal regulation, and social system stability. External system stressors such as disease, psychological stress, injury, or interpersonal conflict may perturb a system, yet simultaneously stimulate oscillatory processes and exercise control mechanisms. Resonance can occur in systems with negative feedback loops, causing high-amplitude oscillations at a single frequency. Resonance effects can be used to strengthen modulatory oscillations, but may obscure other information and control mechanisms, and weaken system stability. Positive as well as negative feedback loops are important for system function and stability. Examples are presented of oscillatory processes in heart rate variability, and regulation of autonomic, thermal, pancreatic and central nervous system processes, as well as in social/organizational systems such as marriages and business organizations. Resonance in negative feedback loops can help stimulate oscillations and exercise control reflexes, but also can deprive the system of important information. Empirical hypotheses derived from this approach are presented, including that moderate stress may enhance health and functioning. PMID:23572244

  17. Comparing biobehavioral profiles across two social stress paradigms in children with and without autism spectrum disorders

    PubMed Central

    2012-01-01

    Background Autism spectrum disorders (ASD) are defined by impairment in reciprocal social interaction and flexible adaptation to the environment. This study compared physiological stress in children with and without ASD exposed to two social stress protocols. We hypothesized that the ASD group would show heightened initial and enduring cortisol levels to the social stressors, which would be moderated by age and intelligence. Methods Twenty-seven children with ASD and 32 with typical development (TYP) completed a standardized social-evaluative performance task and a validated paradigm of social play with peers. Physiological stress was measured by salivary cortisol at nine time points. Statistical approaches included repeated-measures linear mixed models and correlation analyses. Results The average cortisol level of both groups during initial exposure to social situations was significantly greater than baseline levels (ASD, P = 0.018; TYP, P = 0.006). Stress responsivity was significantly different between the groups; the TYP group showed a significant reduction in cortisol over time (P = 0.023), whereas the ASD group maintained an elevated cortisol level (P >0.05). The ASD group evidenced greater variability in between-group, within-group and intra-individual analyses. Age was a positive moderator of stress for the ASD group (P = 0.047), whereas IQ was a negative moderator for the TYP group (P = 0.061). Conclusions Initial stress to novel social scenarios is idiosyncratic and predictive of subsequent exposure. Amidst significant variability in cortisol, children with ASD show enhanced and sustained social stress that increases with age. Developmental and cognitive factors differentially moderate stress in children with ASD and TYP, respectively. A model of neuroendocrine reactivity is proposed. PMID:23158965

  18. Effects of Family-Centered Empowerment Model Based Education Program on Quality of Life in Methamphetamine Users and Their Families

    PubMed Central

    Ghasemi, Afsaneh; Rahimi Foroshani, Abbass; Kheibar, Nasrin; Latifi, Marziye; Khanjani, Narges; Eshagh Afkari, Mohammad; Taghdisi, Mohammad Hossein; Ghasemi, Faranak; Shojaeizadeh, Davoud; Dastoorpour, Maryam

    2014-01-01

    Background: Nowadays there are more concerns about drug treatment of methamphetamine abusers whereas quality of life (QOL) related supportive psychotherapy is less credited. Objectives: This study aimed to evaluate the effects of family-centered empowerment model on social support and QOL of methamphetamine users and their families. Patients and Methods: This study was a randomized clinical trial; individuals were randomly allocated to three groups: a group for educating methamphetamine users in recovery (95 subjects), a group for educating a family member of methamphetamine users in recovery (95 subjects) and a control group (95 subjects). Data collecting instruments were standard questionnaires of social support and health-related quality of life (HRQOL). Data were analyzed using χ2-test, t-test, paired t-test, Pearson’s correlation and ANOVA. Results: Mean scores of QOL and social support dimensions changed significantly in two intervention groups (P < 0.0001), but didn’t change in the control group (P > 0.05). Also, there was a positive significant relation (P < 0.05) between total social support and all dimensions of QOL for all study groups. Conclusions: Family-centered empowerment model, easily adapted to methamphetamine users and their families, leads to improved social supports and QOL. PMID:24829765

  19. A Strengths Model for Learning in a Family Literacy Program.

    ERIC Educational Resources Information Center

    Potts, Meta W.

    Family literacy programs are developed on the premise that the important relationships between children and adults affect literacy achievement and activity. The programs bring parents and children together in a teaching and learning environment. The critical teacher in a child's life is the parent. Family programs support and strengthen family…

  20. Family Involvement Following Institutionalization: Modeling Nursing Home Visits over Time

    ERIC Educational Resources Information Center

    Gaugler, Joseph E.; Zarit, Steven H.; Pearlin, Leonard I.

    2003-01-01

    Gerontological research has emphasized family members' continued involvement in the lives of loved ones following institutionalization. However, many of these studies are cross-sectional in design and do not ascertain how family members' visits change over time. The present study utilized a growth curve analysis to examine preplacement and…

  1. Modeling Familial Cancer with Induced Pluripotent Stem Cells

    PubMed Central

    Lee, Dung-Fang; Su, Jie; Kim, Huen Suk; Chang, Betty; Papatsenko, Dmitri; Zhao, Ruiying; Yuan, Ye; Gingold, Julian; Xia, Weiya; Darr, Henia; Mirzayans, Razmik; Hung, Mien-Chie; Schaniel, Christoph; Lemischka, Ihor R.

    2015-01-01

    SUMMARY In vitro modeling of human disease has recently become feasible with induced pluripotent stem cell (iPSC) technology. Here, we established patient-derived iPSCs from a Li-Fraumeni Syndrome (LFS) family and investigated the role of mutant p53 in the development of osteosarcoma (OS). LFS iPSC-derived osteoblasts (OBs) recapitulated OS features including defective osteoblastic differentiation as well as tumorigenic ability. Systematic analyses revealed that the expression of genes enriched in LFS-derived OBs strongly correlated with decreased time to tumor recurrence and poor patient survival. Furthermore, LFS OBs exhibited impaired upregulation of the imprinted gene H19 during osteogenesis. Restoration of H19 expression in LFS OBs facilitated osteoblastic differentiation and repressed tumorigenic potential. By integrating human imprinted gene network (IGN) into functional genomic analyses, we found that H19 mediates suppression of LFS-associated OS through the IGN component DECORIN (DCN). In summary, these findings demonstrate the feasibility of studying inherited human cancer syndromes with iPSCs. PMID:25860607

  2. On Being a Father or Sibling in Light of the Humanbecoming Family Model.

    PubMed

    Baumann, Steven L; Braddick, Marybeth

    2016-01-01

    The following article provides an updated discussion on two Parse grounded exploratory descriptive studies in light to her recently added humanbecoming family model. The comments of the fathers and siblings from the studies reveal that family life is unpredictable and that family relationships are paradoxical evolutional emergences of shifting hopes and dreams. The humanbecoming family model provided a useful way to consider fathering and being a sibling, as unexpected unfoldings of joy-sorrow reveal purposeful new possibilities. It guides health professionals to avoid the imposition of their views on what is best for the family in favor of bearing witness to the suffering and disappointments that unfold in family life. It is important to remain open to families' sources of meaning, courage, and hope in the moment. PMID:26660776

  3. Developmental Idealism and Cultural Models of the Family in Malawi.

    PubMed

    Thornton, Arland; Pierotti, Rachael S; Young-DeMarco, Linda; Watkins, Susan

    2014-10-01

    This paper examines the extent to which developmental idealism has been disseminated in Malawi. Developmental idealism is a set of beliefs and values about development and the relationships between development and family structures and behavior. Developmental idealism states that attributes of societies and families defined as modern are better than attributes defined as traditional, that modern societies help produce modern families, that modern families facilitate the achievement of modern societies, and that the future will bring family change in the direction of modernity. Previous research has demonstrated that knowledge of developmental idealism is widespread in many places around the world, but provides little systematic data about it in sub-Saharan Africa or how knowledge of it is associated with certain demographic characteristics in that region. In this paper, we address this issue by examining whether ordinary people in two settings in Malawi, a sub-Saharan African country, have received and understood messages that are intended to associate development with certain types of family forms and family behaviors. We then examine associations between demographic characteristics and developmental idealism to investigate possible mechanisms linking global discourse about development to the grassroots. We analyze data collected in face-to-face surveys from two samples of Malawian men in 2009 and 2010, one rural, the other in a low-to-medium income neighborhood of a city. Our analysis of these survey data shows considerable evidence that many developmental idealism beliefs have been spread in that country and that education has positive effects on beliefs in the association between development and family attributes. We also find higher levels of developmental idealism awareness in the urban sample than we do in the rural sample, but once dissimilarities in education and wealth between the two samples are controlled, awareness levels no longer differed between

  4. Developmental Idealism and Cultural Models of the Family in Malawi

    PubMed Central

    Pierotti, Rachael S.; Young-DeMarco, Linda; Watkins, Susan

    2014-01-01

    This paper examines the extent to which developmental idealism has been disseminated in Malawi. Developmental idealism is a set of beliefs and values about development and the relationships between development and family structures and behavior. Developmental idealism states that attributes of societies and families defined as modern are better than attributes defined as traditional, that modern societies help produce modern families, that modern families facilitate the achievement of modern societies, and that the future will bring family change in the direction of modernity. Previous research has demonstrated that knowledge of developmental idealism is widespread in many places around the world, but provides little systematic data about it in sub-Saharan Africa or how knowledge of it is associated with certain demographic characteristics in that region. In this paper, we address this issue by examining whether ordinary people in two settings in Malawi, a sub-Saharan African country, have received and understood messages that are intended to associate development with certain types of family forms and family behaviors. We then examine associations between demographic characteristics and developmental idealism to investigate possible mechanisms linking global discourse about development to the grassroots. We analyze data collected in face-to-face surveys from two samples of Malawian men in 2009 and 2010, one rural, the other in a low-to-medium income neighborhood of a city. Our analysis of these survey data shows considerable evidence that many developmental idealism beliefs have been spread in that country and that education has positive effects on beliefs in the association between development and family attributes. We also find higher levels of developmental idealism awareness in the urban sample than we do in the rural sample, but once dissimilarities in education and wealth between the two samples are controlled, awareness levels no longer differed between

  5. Confusions and Contradictions in Family Policy Developments: Application of a Model.

    ERIC Educational Resources Information Center

    Zimmerman, Shirley L.

    1982-01-01

    Applies a model of change to an analysis of recent developments in family policy. The model includes such concepts as cultural values, ideology, purposive group action, and structural relations. Clarifies some of the contradictions and confusions of recent political and organizational developments concerning families. (Author/RC)

  6. Understanding Chinese American Adolescents' Developmental Outcomes: Insights from the Family Stress Model

    ERIC Educational Resources Information Center

    Benner, Aprile D.; Kim, Su Yeong

    2010-01-01

    In this brief report, we investigated whether the Family Stress Model could be replicated with a sample of Chinese American families. Path analyses with 444 adolescents and their parents provided support for the model's generalizability. Specifically, mothers' and fathers' reports of economic status (i.e., income, financial, and job instability)…

  7. The Family of Origin Parachute Model: Landing Safely in Adult Romantic Relationships

    ERIC Educational Resources Information Center

    Busby, Dean M.; Gardner, Brandt C.; Taniguchi, Narumi

    2005-01-01

    This study investigates the utility of the family of origin parachute model in predicting longitudinal outcomes for couples in romantic relationships. This conceptual model contains common family variables that are theoretically and empirically related to later adult functioning and are believed to influence attitudes that adult children develop…

  8. Counseling Family Members of Addicts/Alcoholics: The Stages of Change Model

    ERIC Educational Resources Information Center

    van Wormer, Katherine

    2008-01-01

    This article adapts the stages of change model, a model in which specific interventions of harm reduction are directed toward the client's readiness for treatment, as a guiding framework for counseling family members of alcoholics/addicts. Interventions at each stage of the family's readiness for change, from precontemplation to action, are…

  9. Using the Rasch Measurement Model in Psychometric Analysis of the Family Effectiveness Measure

    PubMed Central

    McCreary, Linda L.; Conrad, Karen M.; Conrad, Kendon J.; Scott, Christy K; Funk, Rodney R.; Dennis, Michael L.

    2013-01-01

    Background Valid assessment of family functioning can play a vital role in optimizing client outcomes. Because family functioning is influenced by family structure, socioeconomic context, and culture, existing measures of family functioning--primarily developed with nuclear, middle class European American families--may not be valid assessments of families in diverse populations. The Family Effectiveness Measure was developed to address this limitation. Objectives To test the Family Effectiveness Measure with data from a primarily low-income African American convenience sample, using the Rasch measurement model. Method A sample of 607 adult women completed the measure. Rasch analysis was used to assess unidimensionality, response category functioning, item fit, person reliability, differential item functioning by race and parental status, and item hierarchy. Criterion-related validity was tested using correlations with five other variables related to family functioning. Results The Family Effectiveness Measure measures two separate constructs: The effective family functioning construct was a psychometrically sound measure of the target construct that was more efficient due to the deletion of 22 items. The ineffective family functioning construct consisted of 16 of those deleted items but was not as strong psychometrically. Items in both constructs evidenced no differential item functioning by race. Criterion-related validity was supported for both. Discussion In contrast to the prevailing conceptualization that family functioning is a single construct, assessed by positively and negatively worded items, use of the Rasch analysis suggested the existence of two constructs. While the effective family functioning is a strong and efficient measure of family functioning, the ineffective family functioning will require additional item development and psychometric testing. PMID:23636342

  10. Family-Supportive Organization Perceptions, Multiple Dimensions of Work-Family Conflict, and Employee Satisfaction: A Test of Model across Five Samples

    ERIC Educational Resources Information Center

    Lapierre, Laurent M.; Spector, Paul E.; Allen, Tammy D.; Poelmans, Steven; Cooper, Cary L.; O'Driscoll, Michael P.; Sanchez, Juan I.; Brough, Paula; Kinnunen, Ulla

    2008-01-01

    Using samples of managers drawn from five Western countries, we tested a theoretical model linking employees' perceptions of their work environment's family-supportiveness to six different dimensions of work-family conflict (WFC), and to their job satisfaction, family satisfaction, and life satisfaction. Our results are consistent with a causal…

  11. Parametric Modeling in the CAE Process: Creating a Family of Models

    NASA Technical Reports Server (NTRS)

    Brown, Christopher J.

    2011-01-01

    This Presentation meant as an example - Give ideas of approaches to use - The significant benefit of PARAMETRIC geometry based modeling The importance of planning before you build Showcase some NX capabilities - Mesh Controls - Associativity - Divide Face - Offset Surface Reminder - This only had to be done once! - Can be used for any cabinet in that "family" Saves a lot of time if pre-planned Allows re-use in the future

  12. Topic models: A novel method for modeling couple and family text data

    PubMed Central

    Atkins, David C.; Rubin, Tim N.; Steyvers, Mark; Doeden, Michelle A.; Baucom, Brian R.; Christensen, Andrew

    2012-01-01

    Couple and family researchers often collect open-ended linguistic data – either through free response questionnaire items or transcripts of interviews or therapy sessions. Because participant's responses are not forced into a set number of categories, text-based data can be very rich and revealing of psychological processes. At the same time it is highly unstructured and challenging to analyze. Within family psychology analyzing text data typically means applying a coding system, which can quantify text data but also has several limitations, including the time needed for coding, difficulties with inter-rater reliability, and defining a priori what should be coded. The current article presents an alternative method for analyzing text data called topic models (Steyvers & Griffiths, 2006), which has not yet been applied within couple and family psychology. Topic models have similarities with factor analysis and cluster analysis in that topic models identify underlying clusters of words with semantic similarities (i.e., the “topics”). In the present article, a non-technical introduction to topic models is provided, highlighting how these models can be used for text exploration and indexing (e.g., quickly locating text passages that share semantic meaning) and how output from topic models can be used to predict behavioral codes or other types of outcomes. Throughout the article a collection of transcripts from a large couple therapy trial (Christensen et al., 2004) is used as example data to highlight potential applications. Practical resources for learning more about topic models and how to apply them are discussed. PMID:22888778

  13. A Family-Oriented Decision-Making Model for Human Research in Mainland China.

    PubMed

    Rui, Deng

    2015-08-01

    This essay argues that individual-oriented informed consent is inadequate to protect human research subjects in mainland China. The practice of family-oriented decision-making is better suited to guide moral research conduct. The family's role in medical decision-making originates from the mutual benevolence that exists among family members, and is in accordance with family harmony, which is the aim of Confucian society. I argue that the practice of informed consent for medical research on human subjects ought to remain family-oriented in mainland China. This essay explores the main features of this model of informed consent and demonstrates the proper authority of the family. The family's participation in decision-making as a whole does not negate or deny the importance of the individual who is the subject of the choice, but rather acts more fully to protect research subjects. PMID:26142439

  14. The Cancer Family Caregiving Experience: An Updated and Expanded Conceptual Model

    PubMed Central

    Fletcher, Barbara Swore; Miaskowski, Christine; Given, Barbara; Schumacher, Karen

    2011-01-01

    Objective The decade from 2000–2010 was an era of tremendous growth in family caregiving research specific to the cancer population. This research has implications for how cancer family caregiving is conceptualized, yet the most recent comprehensive model of cancer family caregiving was published ten years ago. Our objective was to develop an updated and expanded comprehensive model of the cancer family caregiving experience, derived from concepts and variables used in research during past ten years. Methods A conceptual model was developed based on cancer family caregiving research published from 2000–2010. Results Our updated and expanded model has three main elements: 1) the stress process, 2) contextual factors, and 3) the cancer trajectory. Emerging ways of conceptualizing the relationships between and within model elements are addressed, as well as an emerging focus on caregiver-patient dyads as the unit of analysis. Conclusions Cancer family caregiving research has grown dramatically since 2000 resulting in a greatly expanded conceptual landscape. This updated and expanded model of the cancer family caregiving experience synthesizes the conceptual implications of an international body of work and demonstrates tremendous progress in how cancer family caregiving research is conceptualized. PMID:22000812

  15. Integrating gender on multiple levels: a conceptual model for teaching gender issues in family therapy.

    PubMed

    Williams, Lee; McBain, Heidi

    2006-07-01

    As the field of family therapy has evolved, there has been growing recognition as to the importance of gender in family therapy. To prepare the next generation of family therapists adequately, it is important that they recognize the many and complex ways in which gender permeates their work. In this article we present an integrative model to help educators teach family therapists about gender issues. The model examines how gender influences clinical work on multiple levels, including contextual levels such as society and the marriage and family therapy field. The model also acknowledges how gender can influence individuals, including clients, therapists, and supervisors. Finally, the model attempts to capture the complexity of how gender can impact the relational dynamics between two or more individuals. PMID:16933441

  16. Linking family cohesion and flexibility with expressed emotion, family burden and psychological distress in caregivers of patients with psychosis: A path analytic model.

    PubMed

    Koutra, Katerina; Simos, Panagiotis; Triliva, Sofia; Lionis, Christos; Vgontzas, Alexandros N

    2016-06-30

    The present study aimed to evaluate a path analytic model accounting for caregivers' psychological distress that takes into account perceived family cohesion and flexibility, expressed emotion and caregiver's burden associated with the presence of mental illness in the family. 50 first-episode and 50 chronic patients diagnosed with schizophrenia or bipolar disorder (most recent episode manic severe with psychotic features) recruited from the Inpatient Psychiatric Unit of the University Hospital of Heraklion, Crete, Greece, and their family caregivers participated in the study. Family functioning was assessed in terms of cohesion and flexibility (FACES-IV), expressed emotion (FQ), family burden (FBS) and caregivers' psychological distress (GHQ-28). Structural equation modelling was used to evaluate the direct and indirect effects of family dynamics on caregivers' psychological distress. The results showed that neither family cohesion nor family flexibility exerted significant direct effects on caregivers' psychological distress. Instead, the effect of flexibility was mediated by caregivers' criticism and family burden indicating an indirect effect on caregivers' psychological distress. These results apply equally to caregivers of first episode and chronic patients. Family interventions aiming to improve dysfunctional family interactions by promoting awareness of family dynamics could reduce the burden and improve the emotional well-being of family caregivers. PMID:27085666

  17. Place of family in recovery models for those with a mental illness.

    PubMed

    Reupert, Andrea; Maybery, Darryl; Cox, Merrilee; Scott Stokes, Eileen

    2015-12-01

    Within the context of mental illness, there is an acknowledgement that the social environment is critical to recovery. Nonetheless, how family roles and interactions are presented in recovery frameworks is unclear. This systematic review sought to: (i) identify how family is defined in recovery models, and (ii) synthesize how family relationships and roles are incorporated into recovery models for those with a mental illness. A systematic search of electronic databases was conducted for peer reviewed, English language papers published between 1980 to April 2013, from Ovid MEDLINE, PsycINFO, Proquest, CINAHL plus and Web of Knowledge. Studies were included if they presented a recovery framework and include primary data from people with a mental illness where family was incorporated. A narrative thematic analysis was conducted on the eligible 31 studies, using inductive, open coding techniques. Eight studies did not define what was meant by 'family' while 10 studies focused exclusively on an individual's relationships with parents; six papers collected parenting demographics. Family roles included being a (adult) child, parent, spouse and being part of a 'family'. Family interactions involved being passive recipients of family support, caring for elderly parents and children and reciprocal, give and take relationships. Family interactions and roles offer the opportunity to both facilitate and impede recovery. PMID:26279272

  18. Family of fish-eye-related models and their supersymmetric partners

    SciTech Connect

    Makowski, Adam J.

    2010-05-15

    A large family of potentials related to the Maxwell fish-eye model is derived with the help of conformal mappings. It is shown that the whole family admits square-integrable E=0 solutions of the Schroedinger equation for discrete values of the coupling constant. A corresponding supersymmetric family of partner potentials to the preceding ones is derived as well. Some applications of the considered potentials are also discussed.

  19. Reciprocity Family Counseling: A Multi-Ethnic Model.

    ERIC Educational Resources Information Center

    Penrose, David M.

    The Reciprocity Family Counseling Method involves learning principles of behavior modification including selective reinforcement, behavioral contracting, self-correction, and over-correction. Selective reinforcement refers to the recognition and modification of parent/child responses and reinforcers. Parents and children are asked to identify…

  20. A Family Involvement Model for Hearing-Impaired Infants.

    ERIC Educational Resources Information Center

    Fitzgerald, Mary Trabue; Fischer, Rebecca M.

    1987-01-01

    The Mama Lere Parent-Infant Training Program (Nashville, Tennessee) which serves hearing- and speech-impaired children focuses on family involvement and an intervention plan which includes four service delivery components: facilitation of child communicative competence; educational advocacy and team decision making; information exchange; and…

  1. A Longitudinal Family-Level Model of Arab Muslim Adolescent Behavior Problems

    ERIC Educational Resources Information Center

    Aroian, Karen J.; Templin, Thomas N.; Hough, Edythe Ellison; Ramaswamy, Vidya; Katz, Anne

    2011-01-01

    Arab-American Muslim adolescents in immigrant families face a number of challenges that put them at risk for behavior problems. This study of Arab-American Muslim Adolescents and their relatively recent immigrant mothers tested a longitudinal family-level model of adolescent behavior problems. Mother-adolescent dyads (N = 530) completed measures…

  2. Culture Specific Approaches to the Treatment of Latin Multiple Substance Abusers: Family and Ecological Intervention Models.

    ERIC Educational Resources Information Center

    Szapocznik, Jose; And Others

    Four models developed for the treatment of Cuban American adult and adolescent drug and alcohol abusers are discussed in this paper. The study reviewed was aimed at (1) investigating the effectiveness of "Ecological Family Systems Therapy," an approach created by the Spanish Family Guidance Clinic in Miami, Florida, and (2) identifying the…

  3. Building a Conceptual Model of Family Response to a Child's Chronic Illness or Disability.

    ERIC Educational Resources Information Center

    McDonald, Thomas P.; And Others

    This literature review provides information to help in building a model of family caregiving for children with emotional disorders, focusing on the elements of stress, coping, and appraisal. Because literature on families' perceptions, use of resources, and coping with a child with an emotional disorder is nonexistent, the review uses the…

  4. Rural-Urban Differences in Marital Happiness and Family Satisfaction: Towards a General Model.

    ERIC Educational Resources Information Center

    Thornton-Stahura, Barbara

    Study objectives were to: derive a set of variables originating from background status attainments and proceeding through marital behavior via a literature search; develop models of marital happiness and family satisfaction by residence; delimit specific variables contributing to marital happiness and family satisfaction by residence within the…

  5. Using the Prevent-Teach-Reinforce Model with Families of Young Children with ASD

    ERIC Educational Resources Information Center

    Sears, Kacie M.; Blair, Kwang-Sun Cho; Iovannone, Rose; Crosland, Kimberly

    2013-01-01

    This study was conducted to examine the feasibility and potential efficacy of implementing an adapted, family-centered version of the school-based prevent-teach-reinforce (PTR) model. The research included two families who implemented the PTR process for their children in collaboration with the researchers. The adapted PTR was tested using a…

  6. Comparison of model results transporting the odd nitrogen family with results transporting separate odd nitrogen species

    NASA Technical Reports Server (NTRS)

    Douglass, Anne R.; Jackman, Charles H.; Stolarski, Richard S.

    1989-01-01

    A fast two-dimensional residual circulation stratospheric family transport model, designed to minimize computer requirements, is developed. The model was used to calculate the ambient and perturbed atmospheres in which odd nitrogen species are transported as a family, and the results were compared with calculations in which HNO3, N2O5, ClONO2, and HO2NO2 are transported separately. It was found that ozone distributions computed by the two models for a present-day atmosphere are nearly identical. Good agreement was also found between calculated species concentrations and the ozone response, indicating the general applicability of the odd-nitrogen family approximations.

  7. Models of population-based analyses for data collected from large extended families

    PubMed Central

    Lee, Elisa T.; Howard, Barbara V.; Fabsitz, Richard R.; Devereux, Richard B.; MacCluer, Jean W.; Laston, Sandra; Comuzzie, Anthony G.; Shara, Nawar M.; Welty, Thomas K.

    2014-01-01

    Large studies of extended families usually collect valuable phenotypic data that may have scientific value for purposes other than testing genetic hypotheses if the families were not selected in a biased manner. These purposes include assessing population-based associations of diseases with risk factors/covariates and estimating population characteristics such as disease prevalence and incidence. Relatedness among participants however, violates the traditional assumption of independent observations in these classic analyses. The commonly used adjustment method for relatedness in population-based analyses is to use marginal models, in which clusters (families) are assumed to be independent (unrelated) with a simple and identical covariance (family) structure such as those called independent, exchangeable and unstructured covariance structures. However, using these simple covariance structures may not be optimally appropriate for outcomes collected from large extended families, and may under- or over-estimate the variances of estimators and thus lead to uncertainty in inferences. Moreover, the assumption that families are unrelated with an identical family structure in a marginal model may not be satisfied for family studies with large extended families. The aim of this paper is to propose models incorporating marginal models approaches with a covariance structure for assessing population-based associations of diseases with their risk factors/covariates and estimating population characteristics for epidemiological studies while adjusting for the complicated relatedness among outcomes (continuous/categorical, normally/non-normally distributed) collected from large extended families. We also discuss theoretical issues of the proposed models and show that the proposed models and covariance structure are appropriate for and capable of achieving the aim. PMID:20882324

  8. Inborn errors of metabolism: psychosocial challenges and proposed family systems model of intervention.

    PubMed

    Weber, Stacy L; Segal, Summer; Packman, Wendy

    2012-04-01

    Inborn errors of metabolism result in psychosocial crises that challenge individual and familial modes of functioning across the life cycle. Increased stress, mood disorders, interpersonal challenges, decreased quality of life, and grief reactions are all common for patients and their families. To effectively care for these patients, a holistic approach to their care, which incorporates their social context, is essential. Patients and their families need support as they focus on immediate practical demands, grieve over illness-related losses, and reorient future expectations. A family systems based model provides a flexible and individualized approach to care that allows for optimal psychosocial adjustment throughout the disease process. PMID:22532988

  9. Intellectual Development in Family Constellations with Adopted and Natural Children: A Test of the Zajonc and Markus Model

    ERIC Educational Resources Information Center

    Grotevant, Harold D.; And Others

    1977-01-01

    Presents a study of a theoretical confluence model which predicts the effects of birth order, child spacing and family size on intellectual development. The fit of this model was tested on samples of families with biological and adopted children. (JMB)

  10. The McMaster Model of Family Functioning: observer and parental ratings in a nonclinical sample.

    PubMed

    Stevenson-Hinde, J; Akister, J

    1995-09-01

    The McMaster Model of Family Functioning defines seven dimensions, which may be assessed either by an observer applying a Clinical Rating Scale (CRS) to a semi-structured interview of the family and/or by family members completing a questionnaire, the Family Assessment Device (FAD). The present article applied both methods of assessment, as well as the Dyadic Adjustment Scale (DAS), to a nonclinical sample (N = 105). Interobserver reliability on the CRS was highly significant. Parent (FAD) vs. observer (CRS) agreement was also highly significant, except for Affective Responsiveness and Behavior Control, for which agreement was barely significant. When families were labeled as "healthy" or "unhealthy" according to cut-offs, agreement between observers and parents was high (87%), and disagreements illuminated dynamics of individual families. Finally, the DAS (completed by mothers) was significantly correlated with both the CRS and the FAD, particularly for General Functioning. PMID:8582479

  11. Primary Care Reform: Can Quebec's Family Medicine Group Model Benefit from the Experience of Ontario's Family Health Teams?

    PubMed Central

    Breton, Mylaine; Lévesque, Jean-Frédéric; Pineault, Raynald; Hogg, William

    2011-01-01

    Canadian politicians, decision-makers, clinicians and researchers have come to agree that reforming primary care services is a key strategy for improving healthcare system performance. However, it is only more recently that real transformative initiatives have been undertaken in different Canadian provinces. One model that offers promise for improving primary care service delivery is the family medicine group (FMG) model developed in Quebec. A FMG is a group of physicians working closely with nurses in the provision of services to enrolled patients on a non-geographic basis. The objectives of this paper are to analyze the FMG's potential as a lever for improving healthcare system performance and to discuss how it could be improved. First, we briefly review the history of primary care in Quebec. Then we present the FMG model in relation to the four key healthcare system functions identified by the World Health Organization: (a) funding, (b) generating human and technological resources, (c) providing services to individuals and communities and (d) governance. Next, we discuss possible ways of advancing primary care reform, looking particularly at the family health team (FHT) model implemented in the province of Ontario. We conclude with recommendations to inspire other initiatives aimed at transforming primary care. PMID:23115575

  12. Longitudinal and Integrative Tests of Family Stress Model Effects on Mexican-Origin Adolescents

    PubMed Central

    White, Rebecca M. B.; Liu, Yu; Nair, Rajni L.; Tein, Jenn-Yun

    2015-01-01

    The family stress model represents a common framework through which to examine the effects of environmental stressors on adolescent adjustment. The model suggests that economic and neighborhood stressors influence youth adjustment via disruptions to parenting. Incorporating integrative developmental theory, we examined the degree to which parents’ cultural value orientations mitigated the effects of stressors on parenting disruptions and the degree to which environmental adversity qualified the effect of parenting on adolescent adjustment. We tested the hypothesized Integrative Family Stress Model longitudinally in a sample of mother-youth dyads (N = 749) and father-youth dyads (N = 467) from Mexican origin families, across three times points spanning early to middle adolescence. Providing the first longitudinal evidence of family stress mediated effects, mothers’ perceptions of economic pressure were associated with increases in adolescent externalizing symptoms five years later via intermediate increases in harsh parenting. The remaining findings supported the notion that integrative developmental theory can inform family stress model hypothesis testing that is culturally and contextually relevant for wide range of diverse families and youth. For example, fathers’ perceptions of economic pressure and neighborhood danger had important implications for adolescent internalizing, via reductions in paternal warmth, but only at certain levels of neighborhood adversity. Mothers’ familism value orientations mitigated the effects of economic pressure on maternal warmth, protecting their adolescents from experiencing developmental costs associated with environmental stressors. Results are discussed in terms of identifying how integrative developmental theory intersects with the family stress model to set diverse youth on different developmental pathways. PMID:25751100

  13. An efficient technique for Bayesian modeling of family data using the BUGS software

    PubMed Central

    Bae, Harold T.; Perls, Thomas T.; Sebastiani, Paola

    2014-01-01

    Linear mixed models have become a popular tool to analyze continuous data from family-based designs by using random effects that model the correlation of subjects from the same family. However, mixed models for family data are challenging to implement with the BUGS (Bayesian inference Using Gibbs Sampling) software because of the high-dimensional covariance matrix of the random effects. This paper describes an efficient parameterization that utilizes the singular value decomposition of the covariance matrix of random effects, includes the BUGS code for such implementation, and extends the parameterization to generalized linear mixed models. The implementation is evaluated using simulated data and an example from a large family-based study is presented with a comparison to other existing methods. PMID:25477899

  14. A hierarchical frailty model for familial testicular germ-cell tumors.

    PubMed

    Valberg, Morten; Grotmol, Tom; Tretli, Steinar; Veierød, Marit B; Moger, Tron A; Aalen, Odd O

    2014-02-15

    Using a 2-level hierarchical frailty model, we analyzed population-wide data on testicular germ-cell tumor (TGCT) status in 1,135,320 two-generational Norwegian families to examine the risk of TGCT in family members of patients. Follow-up extended from 1954 (cases) or 1960 (unaffected persons) to 2008. The first-level frailty variable was compound Poisson-distributed. The underlying Poisson parameter was randomized to model the frailty variation between families and was decomposed additively to characterize the correlation structure within a family. The frailty relative risk (FRR) for a son, given a diseased father, was 4.03 (95% confidence interval (CI): 3.12, 5.19), with a borderline significantly higher FRR for nonseminoma than for seminoma (P = 0.06). Given 1 affected brother, the lifetime FRR was 5.88 (95% CI: 4.70, 7.36), with no difference between subtypes. Given 2 affected brothers, the FRR was 21.71 (95% CI: 8.93, 52.76). These estimates decreased with the number of additional healthy brothers. The estimated FRRs support previous findings. However, the present hierarchical frailty approach allows for a very precise definition of familial risk. These FRRs, estimated according to numbers of affected/nonaffected family members, provide new insight into familial TGCT. Furthermore, new light is shed on the different familial risks of seminoma and nonseminoma. PMID:24219863

  15. A Latent Class Model for Testing for Linkage and Classifying Families when the Sample May Contain Segregating and Non-Segregating Families

    PubMed Central

    Bastone, Laurel A.; Spielman, Richard S.; Wang, Xingmei; Ten Have, Thomas R.; Putt, Mary E.

    2010-01-01

    In a quantitative trait locus (QTL) study, it is usually not feasible to select families with offspring that simultaneously display variability in more than one phenotype. When multiple phenotypes are of interest, the sample will, with high probability, contain ‘non-segregating’ families, i.e. families with both parents homozygous at the QTL. These families potentially reduce the power of regression-based methods to detect linkage. Moreover, follow-up studies in individual families will be inefficient, and potentially even misleading, if non-segregating families are selected for the study. Our work extends Haseman-Elston regression using a latent class model to account for the mixture of segregating and non-segregating families. We provide theoretical motivation for the method using an additive genetic model with two distinct functions of the phenotypic outcome, squared difference (SqD) and mean-corrected product (MCP). A permutation procedure is developed to test for linkage; simulation shows that the test is valid for both phenotypic functions. For rare alleles, the method provides increased power compared to a ‘marginal’ approach that ignores the two types of families; for more common alleles, the marginal approach has better power. These results appear to reflect the ability of the algorithm to accurately assign families to the two classes and the relative weights of segregating and non-segregating families to the test of linkage. An application of Bayes rule is used to estimate the family-specific probability of segregating. High predictive value positive values for segregating families, particularly for MCP, suggest that the method has considerable value for identifying segregating families. The method is illustrated for gene expression phenotypes measured on 27 candidate genes previously demonstrated to show linkage in a sample of 14 families. PMID:20558995

  16. Attachment-based family therapy for depressed and suicidal adolescents: theory, clinical model and empirical support.

    PubMed

    Ewing, E Stephanie Krauthamer; Diamond, Guy; Levy, Suzanne

    2015-01-01

    Attachment-Based Family Therapy (ABFT) is a manualized family-based intervention designed for working with depressed adolescents, including those at risk for suicide, and their families. It is an empirically informed and supported treatment. ABFT has its theoretical underpinnings in attachment theory and clinical roots in structural family therapy and emotion focused therapies. ABFT relies on a transactional model that aims to transform the quality of adolescent-parent attachment, as a means of providing the adolescent with a more secure relationship that can support them during challenging times generally, and the crises related to suicidal thinking and behavior, specifically. This article reviews: (1) the theoretical foundations of ABFT (attachment theory, models of emotional development); (2) the ABFT clinical model, including training and supervision factors; and (3) empirical support. PMID:25778674

  17. "All in the Family" in Context: A Unified Model of Media Studies Applied to Television Criticism.

    ERIC Educational Resources Information Center

    Timberg, Bernard

    Proposing the use of a single comprehensive communications model, the Circles of Context Model, for all forms of communication, this paper shows how the model can be used to identify different kinds of criticism of the television comedy series "All in the Family" and the ways in which that criticism shifted during the show's nine-year run.…

  18. Family Resource Systems: The Nebraska Model. Proceedings of the Family Resource Systems Conference (January 24-25, 1980).

    ERIC Educational Resources Information Center

    Stark, Jack A., Ed.

    Proceedings are presented from a 1980 conference on community based services for families of developmentaly disabled children. The following ten papers are included: "Leading Edge Services to Families of Persons with Developmental Disabilities" (R. Perske); "Family Resource Services and Support Systems for Families with Handicapped Children" (B.…

  19. Validating the revised Health Belief Model for young families: implications for nurses' health promotion practice.

    PubMed

    Roden, Janet

    2004-12-01

    By modifying the Health Belief Model (HBM) nurses can provide health promotion guidance for families through the revised HBM for young families. The constructs 'perceived behavioral control' and 'behavioral intention' from Ajzen's Theory of Planned Behavior were added to the HBM to provide a health orientation. An initial qualitative study informed the second quantitative study through thematic data obtained by interviewing parents about family health. The second comparative study of low and high socioeconomic status families of preschool-aged children living in western Sydney, Australia, measured family health through the Parental Health Behavior Questionnaire (PHBQ). After a small pilot study, the researcher distributed 150 questionnaires to center directors from preschools, kindergartens and long day care, who then handed out questionnaires to interested parents. Data collection occurred in 1998 with consenting parents returning the questionnaires for collection by the researchers. A convenience sample of 103 was obtained with a 69% return rate. Analysis was undertaken through MANCOVA. Justification for validity occurred through logical analysis and hypothesis testing, based on the literature, while reliability was acknowledged by undertaking Cronbach coefficient alphas on small variable clusters. Results support the constructs 'perceived behavioral control' and 'behavioral intention' in the revised model, suggesting that for families of different socioeconomic background, differences emerge in terms of their perceived control over their child's health and the initiation of health behaviors for their child. Recommendations for further research are for refinement of the PHBQ, new research with different families, and further testing of all the model constructs. PMID:15507045

  20. Selection of sugar cane full-sib families using mixed models and ISSR markers.

    PubMed

    Almeida, L M; Viana, A P; Gonçalves, G M; Entringer, G C

    2014-01-01

    In 2006, an experiment examining families belonging to the first selection stage of the Sugar Cane Breeding Program of Universidade Federal Rural do Rio de Janeiro/Rede Interuniversitária para o Desenvolvimento do Setor Sucroalcooleiro was conducted. Families and plants within families were evaluated to select superior plants for subsequent stages of the breeding program. The experiment was arranged in a randomized block design, in which progenies were grouped into 4 sets, each with 4 replicates and 100 seedlings per plot. The following traits were evaluated: average stem diameter, total plot weight, number of stems, Brix of the lower stem, and Brix of the upper stem. The study of families used the restricted maximum likelihood/best linear unbiased procedure mixed models. After selection, families were genotyped via inter-simple sequence repeat to assess the genetic distance of genotypes. This approach was found to be efficient for selecting new genotypes. PMID:25501142

  1. A Test of the Family Stress Model on Toddler-Aged Children’s Adjustment Among Hurricane Katrina Impacted and Nonimpacted Low-Income Families

    PubMed Central

    Scaramella, Laura V.; Sohr-Preston, Sara L.; Callahan, Kristin L.; Mirabile, Scott P.

    2010-01-01

    Hurricane Katrina dramatically altered the level of social and environmental stressors for the residents of the New Orleans area. The Family Stress Model describes a process whereby felt financial strain undermines parents’ mental health, the quality of family relationships, and child adjustment. Our study considered the extent to which the Family Stress Model explained toddler-aged adjustment among Hurricane Katrina affected and nonaffected families. Two groups of very low-income mothers and their 2-year-old children participated (pre-Katrina, n = 55; post-Katrina, n = 47). Consistent with the Family Stress Model, financial strain and neighborhood violence were associated with higher levels of mothers’ depressed mood; depressed mood was linked to less parenting efficacy. Poor parenting efficacy was associated to more child internalizing and externalizing problems. PMID:18645744

  2. Two models of multiple family therapy in the treatment of adolescent anorexia nervosa: a systematic review.

    PubMed

    Gelin, Zoé; Cook-Darzens, Solange; Simon, Yves; Hendrick, Stéphan

    2016-03-01

    Multiple family therapy (MFT) is a therapeutic method that brings together several families affected by the same pathology. Although from an ideological and conceptual point of view, MFT is often linked to family therapy and group therapy, it is difficult to define it with precision, a weakness which may in turn hinder research on therapeutic effectiveness. This is most notable in the field of eating disorders (ED) where, in spite of MFT's great popularity, research evidence remains limited. Within the context of a systematic review of the literature on MFT in the treatment of anorexia nervosa, the purpose of this article is to provide a theoretical and clinical framework for describing two MFT models, in an attempt to explore their common and distinct concepts, principles, techniques, and factors of change. The first program is a day treatment adaptation of the Maudsley family-based MFT approach, developed in Belgium at the Therapeutic Centre for Adolescents suffering from Eating Disorders: it focuses on the management of ED symptoms, using a strong cognitive behavioral orientation. The second is an integrated systemic MFT outpatient and inpatient program carried out on the ED unit of a pediatric hospital in Paris, France: it emphasizes intra- and inter-family relationships within a systemic framework. Our effort to describe and compare these two models constitutes a first step toward determining the relative value of different models of MFT. Indeed, each model presents specific characteristics that may make it best suited for specific ED populations and/or types of families. PMID:26223191

  3. Trajectories of Change in Obesity among Tehranian Families: Multilevel Latent Growth Curve Modeling

    PubMed Central

    Akbarzadeh, Mahdi; Mahjub, Hossein; Soltanian, Ali Reza; Daneshpour, Maryam; Morris, Nathan

    2016-01-01

    Objectives. To evaluate the trajectories of change in obesity within and between Tehranian families, who participated in the Tehran Lipid and Glucose Study (TLGS). Methods. This study is a family-based longitudinal design, in four waves. A total of 14761 individuals, within 3980 families, were selected. Three anthropometric measurements, body mass index (BMI), waist circumference (WC), and a body shape index (ABSI), were recorded. Multilevel latent growth curve modeling (MLGCM) approach was used for evaluating the change trajectories in obesity within and between the families. Results. The mean age of the subjects in the present study was 33.28 ± 19.01 (range 3–89 years) and 50.1% were male. Obesity was significantly increased (P < 0.001). Individuals with more fat become obese slower, whereas families with more fat become obese faster (P < 0.001). The initial value and growth rate of WC and ABSI were greater in men than in women, while this result is contrary to BMI (P < 0.001). Conclusions. Our findings demonstrated that there is an alarming increase in the obesity trend in Tehranian families. The important role of the family in the prevention of obesity is highlighted, underlining the need for public health programs, as family centered educations to lifestyle modification, which can address this emerging crisis. PMID:27042349

  4. A Test of the Family Stress Model on Toddler-Aged Children's Adjustment among Hurricane Katrina Impacted and Nonimpacted Low-Income Families

    ERIC Educational Resources Information Center

    Scaramella, Laura V.; Sohr-Preston, Sara L.; Callahan, Kristin L.; Mirabile, Scott P.

    2008-01-01

    Hurricane Katrina dramatically altered the level of social and environmental stressors for the residents of the New Orleans area. The Family Stress Model describes a process whereby felt financial strain undermines parents' mental health, the quality of family relationships, and child adjustment. Our study considered the extent to which the Family…

  5. A path modeling approach to understanding family conflict: Reciprocal patterns of parent coercion and adolescent avoidance

    PubMed Central

    Saxbe, Darby E.; Ramos, Michelle R.; Timmons, Adele C.; Rodriguez, Aubrey R.; Margolin, Gayla

    2014-01-01

    Conflict between parents and adolescents involves reciprocal exchanges in which family members influence and shape each other’s behavior. This study uses multilevel path analysis to examine interrelations in observed behavior during 15-minute conflict discussions conducted by 103 family triads, looking specifically at parent coercive and youth avoidant behaviors. We also explore the moderating roles of parents’ past aggressive family conflict behavior on parents’ responses to youth behavior. Discussions were coded in three-minute segments. Analyses used time-lagged codes so that a family member’s behavior in one segment predicted another family member’s behavior in the following segment. The fully saturated cross-lagged model tested all possible paths (parents’ behavior predicting parents’ and youths’ subsequent behavior, and vice versa). Parents’ coercive behavior was associated with more avoidant youth behavior in the following segment when controlling for youths’ prior avoidant behavior. The opposite direction of effects also emerged: mothers became more coercive when youth were more avoidant in a prior segment. Fathers’ coercive behavior was not associated with youths’ prior behavior and, with both parents in the same model, father and youth behavior were no longer associated; however, fathers’ coercive behavior predicted more mother coercive behavior in the following segment. Mothers who had behaved more aggressively during family conflict over two waves of data collection became more coercive when youths were more avoidant, although parents’ history of aggressive family conflict behavior did not moderate father-to-youth or youth-to-parent paths. PMID:24821521

  6. Augmented composite likelihood for copula modeling in family studies under biased sampling.

    PubMed

    Zhong, Yujie; Cook, Richard J

    2016-07-01

    The heritability of chronic diseases can be effectively studied by examining the nature and extent of within-family associations in disease onset times. Families are typically accrued through a biased sampling scheme in which affected individuals are identified and sampled along with their relatives who may provide right-censored or current status data on their disease onset times. We develop likelihood and composite likelihood methods for modeling the within-family association in these times through copula models in which dependencies are characterized by Kendall's [Formula: see text] Auxiliary data from independent individuals are exploited by augmentating composite likelihoods to increase precision of marginal parameter estimates and consequently increase efficiency in dependence parameter estimation. An application to a motivating family study in psoriatic arthritis illustrates the method and provides some evidence of excessive paternal transmission of risk. PMID:26819481

  7. 'Train the trainer' model: implications for health professionals and farm family health in Australia.

    PubMed

    Brumby, Susan; Smith, Andrew

    2009-01-01

    Australia is a large country with 60% of land used for agricultural production. Its interior is sparsely populated, with higher morbidity and mortality recorded in rural areas, particularly farmers, farm families, and agricultural workers. Rural health professionals in addressing health education gaps of farming groups have reported using behavioralist approaches. These approaches in isolation have been criticized as disempowering for participants who are identified as passive learners or 'empty vessels.' A major challenge in rural health practice is to develop more inclusive and innovative models in building improved health outcomes. The Sustainable Farm Families Train the Trainer (SFFTTT) model is a 5-day program developed by Western District Health Service designed to enhance practice among health professionals working with farm families in Australia. This innovative model of addressing farmer health asks health professionals to understand the context of the farm family and encourages them to value the experience and existing knowledge of the farmer, the family and the farm business. The SFFTTT program has engaged with health agencies, community, government, and industry groups across Australia and over 120 rural nurses have been trained since 2005. These trainers have successfully delivered programs to 1000 farm families, with high participant completion, positive evaluation, and improved health indicators. Rural professionals report changes in how they approach health education, clinical practice, and promotion with farm families and agricultural industries. This paper highlights the success of SFFTTT as an effective tool in enhancing primary health practice in rural and remote settings. The program is benefiting not only drought ravaged farmers but assisting rural nurses, health agencies, and health boards to engage with farm families at a level not identified previously. Furthermore, nurses and health professionals are now embracing a more 'farmer

  8. Preparing the personal physician for practice: changing family medicine residency training to enable new model practice.

    PubMed

    Green, Larry A; Jones, Samuel M; Fetter, Gerald; Pugno, Perry A

    2007-12-01

    After two years of intensive study, in 2004 the Future of Family Medicine report concluded that the current U.S. health care system is inadequate and unsustainable, and called for changes within the specialty of family medicine to ensure the future health of the American public. With guidance and encouragement from many disciplines and health experts, a set of 10 recommendations was established to accomplish a transformative change in how family physicians serve their patients and how the essential function of primary care is achieved. From these recommendations came a period of innovation and experimentation in the training of family physicians, entitled Preparing the Personal Physician for Practice (P4). The P4 project is a carefully designed and evaluated initiative led by the American Board of Family Medicine and the Association of Family Medicine Residency Directors and administered by TransforMED, a practice redesign initiative of the American Academy of Family Physicians. Fourteen family medicine programs were chosen to participate and will put their innovations into practice from 2007 to 2012, during which time regular evaluation will be conducted. The purpose of P4 is to learn how to improve the graduate medical education of family physicians such that they are prepared to be outstanding personal physicians and to work in the new models of practice now emerging. The innovations tested by P4 residencies are expected to inspire substantial changes in the content, structure, and locations of training of family physicians and to guide future revisions in accreditation and certification requirements. PMID:18046133

  9. The Impact of Field Trips and Family Involvement on Mental Models of the Desert Environment

    ERIC Educational Resources Information Center

    Judson, Eugene

    2011-01-01

    This study examined the mental models of the desert environment held by fourth- and seventh-grade students in the USA and whether those mental models could be affected by: (1) classroom field trips to a desert riparian preserve, and (2) interaction with family members at the same preserve. Results generally indicated that students in this study…

  10. Longitudinal and Integrative Tests of Family Stress Model Effects on Mexican Origin Adolescents

    ERIC Educational Resources Information Center

    White, Rebecca M. B.; Liu, Yu; Nair, Rajni L.; Tein, Jenn-Yun

    2015-01-01

    The family stress model represents a common framework through which to examine the effects of environmental stressors on adolescent adjustment. The model suggests that economic and neighborhood stressors influence youth adjustment via disruptions to parenting. Incorporating integrative developmental theory, we examined the degree to which parents'…

  11. The Impact of Role Modeling on Proteges' Personal Learning and Work-to-Family Enrichment

    ERIC Educational Resources Information Center

    Kwan, Ho Kwong; Mao, Yina; Zhang, Haina

    2010-01-01

    The present study investigates the impact of role modeling as perceived by proteges on their personal learning (i.e., relational job learning and personal skill development) and work-to-family enrichment (WFE). Results from a two-wave field survey of 173 proteges in the People's Republic of China indicate that role modeling positively affects…

  12. A Relational Goal-Oriented Model of Optimal Service Delivery to Children and Families

    ERIC Educational Resources Information Center

    King, Gillian

    2009-01-01

    This article presents a Relational Goal-Oriented Model of Service Delivery to Children with physical or mental health difficulties and their families. This research-informed and practice-relevant model provides a broad understanding of what effective service provision entails and requires from practitioners and service organizations. The model…

  13. A Model for Building School-Family-Community Partnerships: Principles and Process

    ERIC Educational Resources Information Center

    Bryan, Julia; Henry, Lynette

    2012-01-01

    The extant literature documents the importance of school counselors' roles in school-family-community partnerships, yet no model exists to guide school counselors through the process of building partnerships. The authors propose a model to help school counselors navigate the process and principles of partnerships. They define partnerships; discuss…

  14. Lepton asymmetries for the Bs→γl+l- decay in a family nonuniversal Z' model

    NASA Astrophysics Data System (ADS)

    Şirvanlı, Berin Belma

    2014-05-01

    The exclusive Bs→γl+l- decay is analyzed in the framework of a family nonuniversal Z' model by calculating the differential branching ratio, double lepton polarizations, and forward-backward asymmetries. Our results are compared against those of the Standard Model. The predictions of this work are hoped to be tested in the near future at LHCb.

  15. The Baby TALK Model: An Innovative Approach to Identifying High-Risk Children and Families

    ERIC Educational Resources Information Center

    Villalpando, Aimee Hilado; Leow, Christine; Hornstein, John

    2012-01-01

    This research report examines the Baby TALK model, an innovative early childhood intervention approach used to identify, recruit, and serve young children who are at-risk for developmental delays, mental health needs, and/or school failure, and their families. The report begins with a description of the model. This description is followed by an…

  16. Supporting resilience in foster families: A model for program design that supports recruitment, retention, and satisfaction of foster families who care for infants with prenatal substance exposure.

    PubMed

    Marcellus, Lenora

    2010-01-01

    As the health, social, and developmental needs of infants in foster care become more complex, foster families are challenged to develop specialized knowledge to effectively address these needs. The goal of this qualitative research study was to identify the process of becoming a foster family and providing family foster caregiving within the context of caring for infants with prenatal drug and alcohol exposure. A constructivist grounded theory approach was used to study foster families (including mothers, fathers, and birth and adoptive children) who specialized in caring for infants within a Canadian provincial child welfare system. This article describes an infant foster care model, applies resilience theory to the model, and provides recommendations for program development for foster families that specialize in the infant population. PMID:20565011

  17. Experience and extensions to the ASM2 family of models.

    PubMed

    Dudley, J; Buck, G; Ashley, R; Jack, A

    2002-01-01

    The development of ASM2 has created a complex model for biological phosphorus removal. Most of the published work on calibrating this model has focused on the design of experiments to maximise information with which to calibrate the model, or the use of hourly data collected around and within an aeration tank. But many sewage works do not collect such data, nor have such instrumentation. The application of ASM2 with sparse data collected at a low frequency, and mostly only input-output, is considered in this paper, based on data collected at a Swedish sewage works. This paper shows that ASM2 can be calibrated with such measurements. This paper also looks at a modification to ASM2d to better handle heterotrophic usage of volatile fatty acids, and the use of this model to study the effects of large increases in in-sewer storage on sewage treatment works. Concern about the generation of large quantities of VFAs, and their effect on the sewage treatment processes, was unfounded. PMID:11989871

  18. Parent and family impact of autism spectrum disorders: a review and proposed model for intervention evaluation.

    PubMed

    Karst, Jeffrey S; Van Hecke, Amy Vaughan

    2012-09-01

    Raising a child with an autism spectrum disorder (ASD) can be an overwhelming experience for parents and families. The pervasive and severe deficits often present in children with ASD are associated with a plethora of difficulties in caregivers, including decreased parenting efficacy, increased parenting stress, and an increase in mental and physical health problems compared with parents of both typically developing children and children with other developmental disorders. In addition to significant financial strain and time pressures, high rates of divorce and lower overall family well-being highlight the burden that having a child with an ASD can place on families. These parent and family effects reciprocally and negatively impact the diagnosed child and can even serve to diminish the positive effects of intervention. However, most interventions for ASD are evaluated only in terms of child outcomes, ignoring parent and family factors that may have an influence on both the immediate and long-term effects of therapy. It cannot be assumed that even significant improvements in the diagnosed child will ameliorate the parent and family distress already present, especially as the time and expense of intervention can add further family disruption. Thus, a new model of intervention evaluation is proposed, which incorporates these factors and better captures the transactional nature of these relationships. PMID:22869324

  19. Who steers the ship? Rural family physicians' views on collaborative care models for patients with dementia.

    PubMed

    Kosteniuk, Julie; Morgan, Debra; Innes, Anthea; Keady, John; Stewart, Norma; D'Arcy, Carl; Kirk, Andrew

    2014-01-01

    Little is known about the views of rural family physicians (FPs) regarding collaborative care models for patients with dementia. The study aims were to explore FPs' views regarding this issue, their role in providing dementia care, and the implications of providing dementia care in a rural setting. This study employed an exploratory qualitative design with a sample of 15 FPs. All rural FPs indicated acceptance of collaborative models. The main disadvantages of practicing rural were accessing urban-based health care and related services and a shortage of local health care resources. The primary benefit of practicing rural was FPs' social proximity to patients, families, and some health care workers. Rural FPs provided care for patients with dementia that took into account the emotional and practical needs of caregivers and families. FPs described positive and negative implications of rural dementia care, and all were receptive to models of care that included other health care professionals. PMID:23552172

  20. Analysis of familial aggregation of atopic eczema and other atopic diseases by ODDS RATIO regression models.

    PubMed

    Diepgen, T L; Blettner, M

    1996-05-01

    In order to determine the relative importance of genetics and the environment on the occurrence of atopic diseases, we investigated the familial aggregation of atopic eczema, allergic rhinitis, and allergic asthma in the relatives of 426 patients with atopic eczema and 628 subjects with no history of eczema (5,136 family members in total). Analyses were performed by regression models for odds ratios (OR) allowing us to estimate OR for the familial aggregation and simultaneously to adjust for other covariates. Three models were analyzed assuming that the OR i) is the same among any two members of a family, ii) depends on different familial constellations, i.e., whether the pairs are siblings, parents, or parent/sibling pairs, and iii) is not the same between the father and the children and between the mother and the children. The OR of familial aggregation for atopic eczema was 2.16 (95% confidence interval (95%-CI) 1.58-2.96) if no distinction was made between the degree of relationship. Further analyses within the members of the family showed a high OR among siblings (OR = 3.86; 95%-CI 2.10-7.09), while the OR between parents and siblings was only 1.90 (95%-CI 1.31-2.97). Only for atopic eczema was the familial aggregation between fathers and siblings (ms: OR = 2.66; fs: OR = 1.29). This can be explained by stronger maternal heritability, shared physical environment of mother and child, or environmental events that affect the fetus in utero. Since for all atopic diseases a stronger correlation was found between siblings than between siblings and parents, our study indicates that environmental factors, especially during childhood, seem to explain the recently observed increased frequencies of atopic diseases. PMID:8618061

  1. A Footprint Family extended MRIO model to support Europe's transition to a One Planet Economy.

    PubMed

    Galli, Alessandro; Weinzettel, Jan; Cranston, Gemma; Ercin, Ertug

    2013-09-01

    Currently, the European economy is using nearly three times the ecological assets that are locally available. This situation cannot be sustained indefinitely. Tools are needed that can help reverse the unsustainable trend. In 2010, an EC funded One Planet Economy Network: Europe (OPEN:EU) project was launched to develop the evidence and innovative practical tools that will allow policy-makers and civil society to identify policy interventions to transform Europe into a One Planet Economy, by 2050. Building on the premise that no indicator alone is able to comprehensively monitor (progress towards) sustainability, the project has drawn on the Ecological, Carbon and Water Footprints to define a Footprint Family suite of indicators, to track human pressure on the planet. An environmentally-extended multi-regional input-output (MRIO) model has then been developed to group the Footprint Family under a common framework and combine the indicators in the family with national economic accounts and trade statistics. Although unable to monitor the full spectrum of human pressures, once grouped within the MRIO model, the Footprint Family is able to assess the appropriation of ecological assets, GHG emissions as well as freshwater consumption and pollution associated with consumption of specific products and services within a specified country. Using MRIO models within the context of Footprint analyses also enables the Footprint Family to take into account full production chains with technologies specific to country of origin. PMID:23273807

  2. The Effectiveness of Structured and Semistructured Satir Model Groups on Family Relationships with College Students in Taiwan.

    ERIC Educational Resources Information Center

    Pan, Peter Jen Der

    2000-01-01

    Examines the effects of group counseling based on the Satir model on college students' family roles and relationships with family members. Forty-two college participants in Taiwan were assigned to one of two experimental conditions. Results reveal that participants' family roles became more positive and definite, and their relationship with family…

  3. The Double ABCX Model of Adaptation in Racially Diverse Families with a School-Age Child with Autism

    ERIC Educational Resources Information Center

    Manning, Margaret M.; Wainwright, Laurel; Bennett, Jillian

    2011-01-01

    In this study, the Double ABCX model of family adaptation was used to explore the impact of severity of autism symptoms, behavior problems, social support, religious coping, and reframing, on outcomes related to family functioning and parental distress. The sample included self-report measures collected from 195 families raising school-age…

  4. Work-Family Conflict Among Newly Licensed Registered Nurses: A Structural Equation Model of Antecedents and Outcomes.

    PubMed

    Unruh, Lynn Y; Raffenaud, Amanda; Fottler, Myron

    2016-01-01

    Conflict between work and family is a human resource management issue that is particularly relevant for nurses. Nursing is a demanding profession, and a high proportion of nurses are women, who tend to have greater family responsibilities than men. Little is known regarding work-family conflict among nurses, and even less is known about how this affects newly licensed registered nurses (NLRNs), who can be stressed from their new jobs and careers. This study empirically tests a model of antecedents and outcomes of work-family and family-work conflict among a sample of NLRNs. We developed a model of the relationships between personal and work environment characteristics, work-family and family-work conflicts, job satisfaction, and intent to leave the job and profession. We used structural equation modeling (Amos, IBM SPSS) to test the model with data from.a survey of NLRNs. We examined a number of latent variables, as well as direct and mediating relationships. The measurement models for all latent variables were validated. The final model indicated that age, health, and family responsibilities are antecedents of family-work conflict; job demands lead to work-family conflict; family-work conflict contributes to job difficulties, which lowers job satisfaction, which, in turn, increases the intent to leave the job and profession; and work-family conflict increases the intent to leave the job and profession (but does not directly affect job satisfaction). Policies to help NLRNs with family responsibilities could reduce family-work conflict, which might reduce job difficulties and improve satisfaction and retention. In addition, policies to reduce job demands could reduce work-family conflict and improve retention. PMID:27111932

  5. Family health advocacy: an empowerment model for pregnant and parenting African American women in rural communities.

    PubMed

    Baffour, Tiffany D; Jones, Maurine A; Contreras, Linda K

    2006-01-01

    The model of family health advocacy built firmly upon principles of empowerment theory seeks to help individuals, families, and communities to improve their circumstances by incorporating multiple levels of intervention. The goal of family health advocacy is to improve the well-being of pregnant women and mothers of children younger than 2 years by providing social support and health education about risk factors related to infant mortality and prematurity. This program primarily targets rural African American women, a group at high risk. Advocacy and referral for needed medical and social services are provided. This article presents a comprehensive model of health advocacy, including social marketing strategies, recruitment efforts, and curriculum development. PMID:16775472

  6. A proposed intergenerational model of substance abuse, family functioning, and abuse/neglect.

    PubMed

    Sheridan, M J

    1995-05-01

    Although the link between substance abuse and child maltreatment has been relatively well established, there is a general recognition that this is not a simple cause-effect relationship. The current study explored the relationships among substance abuse, family functioning, and abuse/neglect in a sample of incarcerated substance abusers. Data were gathered on the earlier life experiences of 81 men and women serving sentences in two maximum security prisons, including assessments of their parents' substance abuse problems; levels of family competence within their families-of-origin; their exposure, as children and adults, to physical, emotional, and sexual abuse and physical/emotional neglect; and their own levels of substance abuse. Results showed generally high percentages of parental substance abuse and abuse/neglect, and relatively low levels of family competence. Correlational analyses revealed significant direct and indirect relationships among parental substance abuse, family dynamics, and exposure to both child and adult maltreatment. These four variables were also significantly associated with respondents' own substance abuse in later life, suggesting the potential for continuation of these patterns into successive generations. An intergenerational model of these family and personal functioning variables is presented and implications for service delivery with correctional clients is discussed. PMID:7664133

  7. Review of family relational stress and pediatric asthma: the value of biopsychosocial systemic models.

    PubMed

    Wood, Beatrice L; Miller, Bruce D; Lehman, Heather K

    2015-06-01

    Asthma is the most common chronic disease in children. Despite dramatic advances in pharmacological treatments, asthma remains a leading public health problem, especially in socially disadvantaged minority populations. Some experts believe that this health gap is due to the failure to address the impact of stress on the disease. Asthma is a complex disease that is influenced by multilevel factors, but the nature of these factors and their interrelations are not well understood. This paper aims to integrate social, psychological, and biological literatures on relations between family/parental stress and pediatric asthma, and to illustrate the utility of multilevel systemic models for guiding treatment and stimulating future research. We used electronic database searches and conducted an integrated analysis of selected epidemiological, longitudinal, and empirical studies. Evidence is substantial for the effects of family/parental stress on asthma mediated by both disease management and psychobiological stress pathways. However, integrative models containing specific pathways are scarce. We present two multilevel models, with supporting data, as potential prototypes for other such models. We conclude that these multilevel systems models may be of substantial heuristic value in organizing investigations of, and clinical approaches to, the complex social-biological aspects of family stress in pediatric asthma. However, additional systemic models are needed, and the models presented herein could serve as prototypes for model development. PMID:25683472

  8. A Research Framework for Understanding the Practical Impact of Family Involvement in the Juvenile Justice System: The Juvenile Justice Family Involvement Model.

    PubMed

    Walker, Sarah Cusworth; Bishop, Asia S; Pullmann, Michael D; Bauer, Grace

    2015-12-01

    Family involvement is recognized as a critical element of service planning for children's mental health, welfare and education. For the juvenile justice system, however, parents' roles in this system are complex due to youths' legal rights, public safety, a process which can legally position parents as plaintiffs, and a historical legacy of blaming parents for youth indiscretions. Three recent national surveys of juvenile justice-involved parents reveal that the current paradigm elicits feelings of stress, shame and distrust among parents and is likely leading to worse outcomes for youth, families and communities. While research on the impact of family involvement in the justice system is starting to emerge, the field currently has no organizing framework to guide a research agenda, interpret outcomes or translate findings for practitioners. We propose a research framework for family involvement that is informed by a comprehensive review and content analysis of current, published arguments for family involvement in juvenile justice along with a synthesis of family involvement efforts in other child-serving systems. In this model, family involvement is presented as an ascending, ordinal concept beginning with (1) exclusion, and moving toward climates characterized by (2) information-giving, (3) information-eliciting and (4) full, decision-making partnerships. Specific examples of how courts and facilities might align with these levels are described. Further, the model makes predictions for how involvement will impact outcomes at multiple levels with applications for other child-serving systems. PMID:26407854

  9. LMX, Breach Perceptions, Work-Family Conflict, and Well-Being: A Mediational Model.

    PubMed

    Hill, Rachel T; Morganson, Valerie J; Matthews, Russell A; Atkinson, Theresa P

    2016-01-01

    Despite research advances, work-family scholars still lack an understanding of how leadership constructs relate to an employee's ability to effectively manage the work-family interface. In addition, there remains a need to examine the process through which leadership and work-family conflict influence well-being outcomes. Using a sample of 312 workers, a mediated process model grounded in social exchange theory is tested wherein the authors seek to explain how leaders shape employee perceptions, which, in turn, impact organizational fulfillment of expectations (i.e., psychological contract breach), work-family conflict, and well-being. A fully latent structural equation model was used to test study hypotheses, all of which were supported. Building on existing theory, findings suggest that the supervisor plays a critical role as a frontline representative for the organization and that work-family conflict is reduced and well-being enhanced through a process of social exchange between the supervisor and worker. PMID:25802949

  10. A Sociocultural Model Relating Family and School Variables to Literacy Learning for Mexican Children

    ERIC Educational Resources Information Center

    Jensen, Bryant T.

    2009-01-01

    This dissertation has three purposes: (a) to structure an argument for binational collaboration of educational advancement for children of Mexican origins; (b) to put forward a conceptual model of how family and school characteristics develop alongside student learning; and (c) to answer a set of questions concerning literacy learning for children…

  11. Female-Headed Families: An Ecological Model of Residential Concentration in a Small City.

    ERIC Educational Resources Information Center

    And Others; Roncek, Dennis W.

    1980-01-01

    Proposed an ecological model to explain the concentration of female-headed families in a small city. Data for city blocks provided patterns of concentration. Of the physical variables, only historical development of the city and market decisions by nonresidential consumers were important predictors of concentration; spatial concentration was not…

  12. Restructuring Routine Parent-Teacher Conferences: The Family-School Conference Model.

    ERIC Educational Resources Information Center

    Minke, Kathleen M.; Anderson, Kellie J.

    2003-01-01

    Compared traditional parent-teacher conferences with an alternative collaborative model that includes students (family-school conferences) in a suburban elementary school. Found that teachers and parents valued traditional conferences as opportunities for information exchange, but both groups reported anxiety that may interfere with communication.…

  13. Developmental Processes in African American Families: An Application of McLoyd's Theoretical Model

    ERIC Educational Resources Information Center

    Nievar, M. Angela; Luster, Tom

    2006-01-01

    In accordance with McLoyd's model of African American children's development, we examined the linkages among family income, maternal psychological distress, marital conflict, parenting, and children's outcomes in early and middle childhood, using a sample of 591 African American children from the National Longitudinal Survey of Youth. Income…

  14. Challenges in Disseminating Model Programs: A Qualitative Analysis of the Strengthening Washington DC Families Program

    ERIC Educational Resources Information Center

    Fox, Danielle Polizzi; Gottfredson, Denise C.; Kumpfer, Karol K.; Beatty, Penny D.

    2004-01-01

    This article discusses the challenges faced when a popular model program, the Strengthening Families Program, which in the past has been implemented on a smaller scale in single organizations, moves to a larger, multiorganization endeavor. On the basis of 42 interviews conducted with program staff, the results highlight two main themes that…

  15. Children at Risk for Academic Failure: A Model of Individual and Family Factors

    ERIC Educational Resources Information Center

    Quilliams, Laura; Beran, Tanya

    2009-01-01

    The purpose of this study was to identify individual and family risk factors that may explain why some students are at risk for academic failure. Students' self-concept, academic motivation, and their parents' involvement in education were reported by both students and teachers. A latent variable path model fit the data well (Comparative Fit Index…

  16. Toward a Dialectical Model of Family Gender Discourse: Body, Identity, and Sexuality.

    ERIC Educational Resources Information Center

    Blume, Libby Balter; Blume, Thomas W.

    2003-01-01

    Proposes a dialectical model representing gender discourse in families. A brief review of literature in sociology, psychology, and gender studies focuses on three dialectical issues: nature versus culture, similarity versus difference, and stability versus fluidity. Deconstructing gender theories from a postmodern feminist perspective, the authors…

  17. Applying the Nominal Response Model within a Longitudinal Framework to Construct the Positive Family Relationships Scale

    ERIC Educational Resources Information Center

    Preston, Kathleen Suzanne Johnson; Parral, Skye N.; Gottfried, Allen W.; Oliver, Pamella H.; Gottfried, Adele Eskeles; Ibrahim, Sirena M.; Delany, Danielle

    2015-01-01

    A psychometric analysis was conducted using the nominal response model under the item response theory framework to construct the Positive Family Relationships scale. Using data from the Fullerton Longitudinal Study, this scale was constructed within a long-term longitudinal framework spanning middle childhood through adolescence. Items tapping…

  18. A Formative Evaluation of the Children, Youth, and Families at Risk Coaching Model

    ERIC Educational Resources Information Center

    Olson, Jonathan R.; Smith, Burgess; Hawkey, Kyle R.; Perkins, Daniel F.; Borden, Lynne M.

    2016-01-01

    In this article, we describe the results of a formative evaluation of a coaching model designed to support recipients of funding through the Children, Youth, and Families at Risk (CYFAR) initiative. Results indicate that CYFAR coaches draw from a variety of types of coaching and that CYFAR principle investigators (PIs) are generally satisfied with…

  19. Parent Power Nights: A Model for Engaging Adults/Families in Learning Mathematics

    ERIC Educational Resources Information Center

    Kosheleva, Olga; Lesser, Larry; Munter, Judith; Trillo, Sylvia

    2008-01-01

    Located on the U.S./México border, The University of Texas at El Paso (UTEP) offers academic programs in K-12 school teacher preparation. Many of the courses integrate parents and families into teacher preparation courses. One example of effective adult/community learning is the "Parent Power Night" (PPN) component. This model builds a…

  20. The Conservation of Resources Model Applied to Work-Family Conflict and Strain.

    ERIC Educational Resources Information Center

    Grandey, Alicia A.; Cropanzano, Russell

    1999-01-01

    Using time-lagged research design and path analysis, findings from 132 college faculty supported the conservation of resources model, which predicts that, as chronic work and family stressors drain resources, dissatisfaction and life distress increase and health declines. Self-esteem was not a moderating variable. (SK)

  1. Breaking the Patriarchal Vision of Social Science: Lessons from a Family Therapy Model.

    ERIC Educational Resources Information Center

    McNamee, Sheila

    The Milan model of systemic family therapy, developed in Italy and based on G. Bateson's cybernetic epistemology, can help meet the goals of a feminist/systemic epistemology in research by accepting data in its "traditional" form yet also connecting it to the act of researching, itself, thereby merging a feminist perspective with the domain of…

  2. Socialization of Coping with Community Violence: Influences of Caregiver Coaching, Modeling, and Family Context

    ERIC Educational Resources Information Center

    Kliewer, Wendy; Parrish, Katie Adams; Taylor, Kelli W.; Jackson, Kate; Walker, Jean M.; Shivy, Victoria A.

    2006-01-01

    A socialization model of coping with community violence was tested in 101 African American adolescents (55% male, ages 9-13) and their maternal caregivers living in high-violence areas of a mid-sized, southeastern city. Participants completed interviews assessing caregiver coping, family context, and child adjustment. Caregiver-child dyads also…

  3. McCoy Manor: A Model Family Literacy-Housing Authority Program. Final Report.

    ERIC Educational Resources Information Center

    Fisher, Allison L.

    A project operated a model, adaptable family literacy program in a housing authority that served 35 residents. Its objectives were to improve parents' basic skills and help them improve their ability to assist their children, to assist parents in learning appropriate expectations for their children and understanding individual differences, and to…

  4. Brief Strategic Family Therapy: Implementing evidence-based models in community settings

    PubMed Central

    Szapocznik, José; Muir, Joan A.; Duff, Johnathan H.; Schwartz, Seth J.; Brown, C. Hendricks

    2014-01-01

    Reflecting a nearly 40-year collaborative partnership between clinical researchers and clinicians, the present article reviews the authors’ experience in developing, investigating, and implementing the Brief Strategic Family Therapy (BSFT) model. The first section of the article focuses on the theory, practice, and studies related to this evidence-based family therapy intervention targeting adolescent drug abuse and delinquency. The second section focuses on the implementation model created for the BSFT intervention– a model that parallels many of the recommendations furthered within the implementation science literature. Specific challenges encountered during the BSFT implementation process are reviewed, along with ways of conceptualizing and addressing these challenges from a systemic perspective. The implementation approach that we employ uses the same systemic principles and intervention techniques as those that underlie the BSFT model itself. Recommendations for advancing the field of implementation science, based on our on-the-ground experiences, are proposed. PMID:24274187

  5. Pre-test prediction models of BRCA1 or BRCA2 mutation in breast/ovarian families attending familial cancer clinics

    PubMed Central

    de la Hoya, M; Diez, O; Perez-Segura, P; Godino, J; Fernandez, J; Sanz, J; Alonso, C; Baiget, M; Diaz-Rubio, E; Caldes, T

    2003-01-01

    Objective: To test whether statistical models developed to calculate pre-test probability of being a BRCA1/2 carrier can differentiate better between the breast/ovarian families to be referred to the DNA test laboratory. Study design: A retrospective analysis was performed in 109 Spanish breast/ovarian families previously screened for germline mutations in both the BRCA1 and BRCA2 genes. Four easy to use logistic regression models originally developed in Spanish (HCSC model), Dutch (LUMC model), Finnish (HUCH model), and North American (U Penn model) families and one model based on empirical data of Frank 2002 were tested. A risk counsellor was asked to assign a subjective pre-test probability for each family. Sensitivity, specificity, negative and positive predictive values, and areas under receiver operator characteristics (ROC) curves were calculated in each case. Correlation between predicted probability and mutation prevalence was tested. All statistical tests were two sided. Results: Overall, the models performed well, improving the performances of a genetic counsellor. The median ROC curve area was 0.80 (range 0.77-0.82). At 100% sensitivity, the median specificity was 30% (range 25-33%). At 92% sensitivity, the median specificity was 42% (range 33.3-54.2%) and the median negative predictive value was 93% (range 89.7-98%). BRCA1 families tended to score higher risk than BRCA2 families in all models tested. Conclusions: All models increased the discrimination power of an experienced risk counsellor, suggesting that their use is valuable in the context of clinical counselling and genetic testing to optimise selection of patients for screening and allowing for more focused management. Models developed in different ethnic populations performed similarly well in a Spanish series of families, suggesting that models targeted to specific populations may not be necessary in all cases. Carrier probability as predicted by the models is consistent with actual prevalence

  6. Cognitive-Existential Family Therapy: A Proposed Theoretical Integration Model for Pastoral Counselors.

    PubMed

    Saunders, James A

    2015-03-01

    Fundamental Christianity and psychology are frequently viewed as incompatible pursuits. However, proponents of the integrationist movement posit that pastoral counselors can utilize principles from psychology if they adopt the premise that all truth is God's truth. Assuming this perspective, Cognitive-Existential Family Therapy (CEFT) - a theoretical integration model compatible with Christian fundamentalism - is proposed. The philosophical assumptions and models of personality, health, and abnormality are explored. Additionally, the article provides an overview of the therapeutic process. PMID:26162205

  7. An explicit SU(12) family and flavor unification model with natural fermion masses and mixings

    SciTech Connect

    Albright, Carl H.; Feger, Robert P.; Kephart, Thomas W.

    2012-07-01

    We present an SU(12) unification model with three light chiral families, avoiding any external flavor symmetries. The hierarchy of quark and lepton masses and mixings is explained by higher dimensional Yukawa interactions involving Higgs bosons that contain SU(5) singlet fields with VEVs about 50 times smaller than the SU(12) unification scale. The presented model has been analyzed in detail and found to be in very good agreement with the observed quark and lepton masses and mixings.

  8. Breaking the Cycle of Illiteracy: The Kenan Family Literacy Model Program. The William R. Kenan, Jr. Charitable Trust Family Literacy Project. Final Report 1988-1989.

    ERIC Educational Resources Information Center

    Darling, Sharon; Hayes, Andrew E.

    The Kenan Trust Family Literacy Project was implemented during the 1988-89 school year at three model sites in Louisville, Kentucky, and four in North Carolina. The model was designed to teach undereducated parents together with their 3- or 4-year-old children. Children participated in a comprehensive preschool program while adults studied in…

  9. Uncovering a family caregiving model: insights from research to benefit HIV-infected patients, their caregivers, and health professionals.

    PubMed

    Wacharasin, Chintana; Homchampa, Pissamai

    2008-01-01

    The purpose of this study was to understand family caregiving practices for HIV-infected patients, including problems and needs based on experiences of primary family caregivers and persons living with HIV (PLWH) in Rayong province, Thailand. The participants were 48 PLWH and 48 primary family caregivers. Data collection consisted of individual in-depth interviews of PLWH and family caregivers, plus focus groups with the primary family caregivers and observations. Content analysis was performed to analyze the qualitative data. Results indicated that there was a transformation in family caregivers from the time of initial diagnosis to their offering of loving, caregiving practices. The most unexpected result was that primary family caregivers evolved their own model for caregiving practices; the most concerning result was their fear of stigmatization. Caregiving practices included seeking treatment and help, providing support and care, keeping the closure of diagnosis, coping with stress, requesting the truth about diagnosis, and maintaining family values and dignity. PMID:18762146

  10. Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model

    PubMed Central

    Bissig-Choisat, Beatrice; Wang, Lili; Legras, Xavier; Saha, Pradip K.; Chen, Leon; Bell, Peter; Pankowicz, Francis P.; Hill, Matthew C.; Barzi, Mercedes; Leyton, Claudia Kettlun; Leung, Hon-Chiu Eastwood; Kruse, Robert L.; Himes, Ryan W.; Goss, John A.; Wilson, James M.; Chan, Lawrence; Lagor, William R.; Bissig, Karl-Dimiter

    2015-01-01

    Diseases of lipid metabolism are a major cause of human morbidity, but no animal model entirely recapitulates human lipoprotein metabolism. Here we develop a xenograft mouse model using hepatocytes from a patient with familial hypercholesterolaemia caused by loss-of-function mutations in the low-density lipoprotein receptor (LDLR). Like familial hypercholesterolaemia patients, our familial hypercholesterolaemia liver chimeric mice develop hypercholesterolaemia and a 'humanized‘ serum profile, including expression of the emerging drug targets cholesteryl ester transfer protein and apolipoprotein (a), for which no genes exist in mice. We go on to replace the missing LDLR in familial hypercholesterolaemia liver chimeric mice using an adeno-associated virus 9-based gene therapy and restore normal lipoprotein profiles after administration of a single dose. Our study marks the first time a human metabolic disease is induced in an experimental animal model by human hepatocyte transplantation and treated by gene therapy. Such xenograft platforms offer the ability to validate human experimental therapies and may foster their rapid translation into the clinic. PMID:26081744

  11. Different concepts and models of information for family-relevant genetic findings: comparison and ethical analysis.

    PubMed

    Lenk, Christian; Frommeld, Debora

    2015-08-01

    Genetic predispositions often concern not only individual persons, but also other family members. Advances in the development of genetic tests lead to a growing number of genetic diagnoses in medical practice and to an increasing importance of genetic counseling. In the present article, a number of ethical foundations and preconditions for this issue are discussed. Four different models for the handling of genetic information are presented and analyzed including a discussion of practical implications. The different models' ranges of content reach from a strictly autonomous position over self-governed arrangements in the practice of genetic counseling up to the involvement of official bodies and committees. The different models show a number of elements which seem to be very useful for the handling of genetic data in families from an ethical perspective. In contrast, the limitations of the standard medical attempt regarding confidentiality and personal autonomy in the context of genetic information in the family are described. Finally, recommendations for further ethical research and the development of genetic counseling in families are given. PMID:25894235

  12. Should the Confucian family-determination model be rejected? A case study.

    PubMed

    Li, En-Chang; Wen, Chun-Feng

    2010-10-01

    This essay explores a tragic event that happened in China, which garnered much attention, the Li case: a young woman who was nine months pregnant and her baby died as a result of the failure to receive a medically necessary c-section due to the hospital having failed to secure her family's consent for the c-section. Differing from some critiques, this essay argues that the Li case should not be used to blame the Confucian family-determination model that has been applied in Chinese society for thousands of years. Based on summarizing the reasons supporting the model, this essay indicates that it is an integral part of the model that, in emergency or special cases, the physician must take medical action to save the patient, without the need to secure the consent of a family member. In order to prevent tragic cases like the Li case from happening, we recommend that relevant Chinese laws be further developed and specified and that, most importantly, Chinese physicians must cultivate the Confucian virtue of benevolence in their practice of taking care of patients in a virtuous way, along with patients' families. PMID:20923930

  13. A simple marriage model for the power-law behaviour in the frequency distributions of family names

    NASA Astrophysics Data System (ADS)

    Wu, Hao-Yun; Chou, Chung-I.; Tseng, Jie-Jun

    2011-01-01

    In many countries, the frequency distributions of family names are found to decay as a power law with an exponent ranging from 1.0 to 2.2. In this work, we propose a simple marriage model which can reproduce this power-law behaviour. Our model, based on the evolution of families, consists of the growth of big families and the formation of new families. Preliminary results from the model show that the name distributions are in good agreement with empirical data from Taiwan and Norway.

  14. Significant speedup of database searches with HMMs by search space reduction with PSSM family models

    PubMed Central

    Beckstette, Michael; Homann, Robert; Giegerich, Robert; Kurtz, Stefan

    2009-01-01

    Motivation: Profile hidden Markov models (pHMMs) are currently the most popular modeling concept for protein families. They provide sensitive family descriptors, and sequence database searching with pHMMs has become a standard task in today's genome annotation pipelines. On the downside, searching with pHMMs is computationally expensive. Results: We propose a new method for efficient protein family classification and for speeding up database searches with pHMMs as is necessary for large-scale analysis scenarios. We employ simpler models of protein families called position-specific scoring matrices family models (PSSM-FMs). For fast database search, we combine full-text indexing, efficient exact p-value computation of PSSM match scores and fast fragment chaining. The resulting method is well suited to prefilter the set of sequences to be searched for subsequent database searches with pHMMs. We achieved a classification performance only marginally inferior to hmmsearch, yet, results could be obtained in a fraction of runtime with a speedup of >64-fold. In experiments addressing the method's ability to prefilter the sequence space for subsequent database searches with pHMMs, our method reduces the number of sequences to be searched with hmmsearch to only 0.80% of all sequences. The filter is very fast and leads to a total speedup of factor 43 over the unfiltered search, while retaining >99.5% of the original results. In a lossless filter setup for hmmsearch on UniProtKB/Swiss-Prot, we observed a speedup of factor 92. Availability: The presented algorithms are implemented in the program PoSSuMsearch2, available for download at http://bibiserv.techfak.uni-bielefeld.de/possumsearch2/. Contact: beckstette@zbh.uni-hamburg.de Supplementary information: Supplementary data are available at Bioinformatics online. PMID:19828575

  15. Sculpting present and future: a systemic intervention model applied to psychosomatic families.

    PubMed

    Onnis, L; Di Gennaro, A; Cespa, G; Agostini, B; Chouhy, A; Dentale, R C; Quinzi, P

    1994-09-01

    We present a therapeutic intervention model for use with psychosomatic families. This method, the result of our extensive research on various psychosomatic disorders, uses family sculptures of the "present" and "future": each family member is requested to represent the family as it now "is," and how it "will be" in the future. We discuss the theoretical reasons for our choice of this method: (a) the opportunity to use a therapeutic language that is similar to the nonverbal language of the psychosomatic symptom, and (b) the usefulness of reinserting temporal dimensions into family systems that seem to have lost their evolutionary potential and to be in a sort of "time lock." Two clinical cases are discussed (a child with chronic asthma and an anorexic adolescent); the use of sculptures in both cases revealed the underlying problems and made positive therapeutic interventions possible. Finally, we point out how the use of sculpture as a therapeutic technique enables therapists to deal with multiple systemic levels. PMID:7828715

  16. b {r-arrow} s transitions in family-dependent U(1)' models.

    SciTech Connect

    Barger, V.; Everett, L.; Jiang, J.; Langacker, P.; Liu, T.; Wagner, C. E. M.; High Energy Physics; Univ. of Chicago; Univ. of Wisconsin; Inst. for Advanced Study

    2009-01-01

    We analyze flavor-changing-neutral-current (FCNC) effects in the b {yields} s transitions that are induced by family non-universal U(1){prime} gauge symmetries. After systematically developing the necessary formalism, we present a correlated analysis for the {Delta}B = 1,2 processes. We adopt a model-independent approach in which we only require family-universal charges for the first and second generations and small fermion mixing angles. We analyze the constraints on the resulting parameter space from B{sub s}-{bar B} mixing and the time-dependent CP asymmetries of the penguin-dominated B{sub d} {yields} ({pi},{phi}, {eta}{prime}, {rho},{omega},f0)K{sub S} decays. Our results indicate that the currently observed discrepancies in some of these modes with respect to the Standard Model predictions can be consistently accommodated within this general class of models.

  17. A risk management model for familial breast cancer: A new application using Fuzzy Cognitive Map method.

    PubMed

    Papageorgiou, Elpiniki I; Jayashree Subramanian; Karmegam, Akila; Papandrianos, Nikolaos

    2015-11-01

    Breast cancer is the most deadly disease affecting women and thus it is natural for women aged 40-49 years (who have a family history of breast cancer or other related cancers) to assess their personal risk for developing familial breast cancer (FBC). Besides, as each individual woman possesses different levels of risk of developing breast cancer depending on their family history, genetic predispositions and personal medical history, individualized care setting mechanism needs to be identified so that appropriate risk assessment, counseling, screening, and prevention options can be determined by the health care professionals. The presented work aims at developing a soft computing based medical decision support system using Fuzzy Cognitive Map (FCM) that assists health care professionals in deciding the individualized care setting mechanisms based on the FBC risk level of the given women. The FCM based FBC risk management system uses NHL to learn causal weights from 40 patient records and achieves a 95% diagnostic accuracy. The results obtained from the proposed model are in concurrence with the comprehensive risk evaluation tool based on Tyrer-Cuzick model for 38/40 patient cases (95%). Besides, the proposed model identifies high risk women by calculating higher accuracy of prediction than the standard Gail and NSAPB models. The testing accuracy of the proposed model using 10-fold cross validation technique outperforms other standard machine learning based inference engines as well as previous FCM-based risk prediction methods for BC. PMID:26220142

  18. Beyond Main Effects Models of Adolescent Work Intensity, Family Closeness, and School Disengagement: Mediational and Conditional Hypotheses.

    ERIC Educational Resources Information Center

    Roisman, Glenn I.

    2002-01-01

    Interviewed adolescents in grades 9 through 12 to examine family closeness as either mediator or moderator of relationships between intense work and academic engagement. Found that for boys, the family closeness mediational model provided best fit for data; for girls, the moderator model fit best. Found girls were especially vulnerable to negative…

  19. Incorporating Religiosity into a Developmental Model of Positive Family Functioning across Generations

    PubMed Central

    Spilman, Sarah K.; Neppl, Tricia K.; Donnellan, M. Brent; Schofield, Thomas J.; Conger, Rand D.

    2012-01-01

    This study evaluated a developmental model of intergenerational continuity in religiosity and its association with observed competency in romantic and parent-child relationships across two generations. Using multi-informant data from the Family Transitions Project, a 20-year longitudinal study of families that began during early adolescence (N = 451), we found that parental religiosity assessed during the youth’s adolescence was positively related to the youth’s own religiosity during adolescence which, in turn, predicted their religiosity after the transition to adulthood. The findings also supported the theoretical model guiding the study, which proposes that religiosity acts as a personal resource that will be uniquely and positively associated with the quality of family relationships. Especially important, the findings demonstrate support for the role of religiosity in a developmental process that promotes positive family functioning after addressing earlier methodological limitations in this area of study, such as cross-sectional research designs, single informant measurement, retrospective reports, and the failure to control for other individual differences. PMID:22545832

  20. Structural propensities of kinase family proteins from a Potts model of residue co-variation.

    PubMed

    Haldane, Allan; Flynn, William F; He, Peng; Vijayan, R S K; Levy, Ronald M

    2016-08-01

    Understanding the conformational propensities of proteins is key to solving many problems in structural biology and biophysics. The co-variation of pairs of mutations contained in multiple sequence alignments of protein families can be used to build a Potts Hamiltonian model of the sequence patterns which accurately predicts structural contacts. This observation paves the way to develop deeper connections between evolutionary fitness landscapes of entire protein families and the corresponding free energy landscapes which determine the conformational propensities of individual proteins. Using statistical energies determined from the Potts model and an alignment of 2896 PDB structures, we predict the propensity for particular kinase family proteins to assume a "DFG-out" conformation implicated in the susceptibility of some kinases to type-II inhibitors, and validate the predictions by comparison with the observed structural propensities of the corresponding proteins and experimental binding affinity data. We decompose the statistical energies to investigate which interactions contribute the most to the conformational preference for particular sequences and the corresponding proteins. We find that interactions involving the activation loop and the C-helix and HRD motif are primarily responsible for stabilizing the DFG-in state. This work illustrates how structural free energy landscapes and fitness landscapes of proteins can be used in an integrated way, and in the context of kinase family proteins, can potentially impact therapeutic design strategies. PMID:27241634

  1. From Family Violence to Dating Violence: Testing a Dual Pathway Model.

    PubMed

    Morris, Anjana Madan; Mrug, Sylvie; Windle, Michael

    2015-09-01

    Risk factors for adolescent perpetration of or victimization by dating violence stem from different levels of adolescents' social ecologies, including the family, individual, and peer domains. However, these multiple risk factors have not been fully integrated into a single comprehensive model of dating violence development. The present study examined prospective links between exposure to family violence in pre-adolescence; pro-violent beliefs, aggression, deviant peer affiliation, and aggression toward opposite-sex peers in early adolescence and dating violence in late adolescence. Using a longitudinal study of 461 youth (51 % female; 80 % African American, 19 % Caucasian, 1 % other ethnicities), path modeling evaluated a theoretically developed dual pathway model involving a general violence pathway and an early romantic aggression pathway. Each pathway links exposure to family violence in pre-adolescence with early adolescent pro-violent beliefs and/or aggressive behavior. In both pathways, pro-violent beliefs may reinforce aggressive behaviors between same-sex and opposite-sex peers, as well as strengthen bonds with deviant peers. In the last part of both pathways, aggressive behavior and peer deviance in early adolescence may contribute directly to late adolescent dating violence perpetration and victimization. The findings provided support for both pathways, as well as sex differences in the model. PMID:26208831

  2. A new model of physical evolution of Jupiter-family comets

    NASA Astrophysics Data System (ADS)

    Rickman, H.; Szutowicz, S.; Wójcikowski, K.

    2014-07-01

    We aim to find the statistical physical lifetimes of Jupiter Family comets. For this purpose, we try to model the processes that govern the dynamical and physical evolution of comets. We pay special attention to physical evolution; attempts at such modelling have been made before, but we propose a more accurate model, which will include more physical effects. The model is tested on a sample of fictitious comets based on real Jupiter Family comets with some orbital elements changed to a state before the capture by Jupiter. We model four different physical effects: erosion by sublimation, dust mantling, rejuvenation (mantle blow-off), and splitting. While for sublimation and splitting there already are some models, like di Sisto et. al. (2009), and we only wish to make them more accurate, dust mantling and rejuvenation have not been included in previous, statistical physical evolution models. Each of these effects depends on one or more tunable parameters, which we establish by choosing the model that best fits the observed comet sample in a way similar to di Sisto et. al. (2009). In contrast to di Sisto et. al., our comparison also involves the observed active fractions vs. nuclear radii.

  3. A Novel Approach for Identifying Causal Models of Complex Diseases from Family Data

    PubMed Central

    Park, Leeyoung; Kim, Ju H.

    2015-01-01

    Causal models including genetic factors are important for understanding the presentation mechanisms of complex diseases. Familial aggregation and segregation analyses based on polygenic threshold models have been the primary approach to fitting genetic models to the family data of complex diseases. In the current study, an advanced approach to obtaining appropriate causal models for complex diseases based on the sufficient component cause (SCC) model involving combinations of traditional genetics principles was proposed. The probabilities for the entire population, i.e., normal–normal, normal–disease, and disease–disease, were considered for each model for the appropriate handling of common complex diseases. The causal model in the current study included the genetic effects from single genes involving epistasis, complementary gene interactions, gene–environment interactions, and environmental effects. Bayesian inference using a Markov chain Monte Carlo algorithm (MCMC) was used to assess of the proportions of each component for a given population lifetime incidence. This approach is flexible, allowing both common and rare variants within a gene and across multiple genes. An application to schizophrenia data confirmed the complexity of the causal factors. An analysis of diabetes data demonstrated that environmental factors and gene–environment interactions are the main causal factors for type II diabetes. The proposed method is effective and useful for identifying causal models, which can accelerate the development of efficient strategies for identifying causal factors of complex diseases. PMID:25701286

  4. Income and Family Events: Family Income, Family Size, and Consumption

    ERIC Educational Resources Information Center

    Cutright, Phillips

    1971-01-01

    This paper considers the structure of family income, examines some factors affecting family size, reviews alternative definitions of an adequate income for families with varying numbers, and presents data on actual consumption, according to family income and family size. A model depicting the causal relations among factors affecting consumption is…

  5. Feasibility and potential efficacy of the family-centered Prevent-Teach-Reinforce model with families of children with developmental disorders.

    PubMed

    Bailey, Kathleen M; Blair, Kwang-Sun Cho

    2015-12-01

    This study examined the feasibility and potential efficacy of the family-centered Prevent-Teach-Reinforce (PTR) model with three families of young children with an autism spectrum disorder or language delay with sensory processing problems. Particularly, the study assessed the family adherence to the PTR intervention, changes in child behavior, family use of the Individualized Behavior Rating Scale Tool (IBRST), procedural integrity, and social validity. A multiple-baseline design across families was used to examine the functional relation between parent-implemented PTR intervention and changes in child behavior. Results indicated that the family-centered PTR process was successful in promoting parents to design and implement the PTR intervention plans with fidelity, and the parents' implemented intervention plans were effective in increasing replacement behavior and decreasing problem behavior across children. The results also indicated that the parents successfully used the IBRST to monitor their child's progress and were highly satisfied with the PTR intervention process and outcomes for their children. PMID:26451882

  6. Divergent Evolution Paths of Different Genetic Families in the Penna Model

    NASA Astrophysics Data System (ADS)

    Sitarz, Mikołaj; Maksymowicz, Andrzej

    We present some simulations results of population growth and evolution, using the standard asexual Penna model, with individuals characterized by a string of bits representing a genome containing some possible mutations. After about 20 000 simulation steps, when only a few genetic families are still present from among rich variety of families at the beginning of the simulation game, strong peaks in mutation distribution functions are observed. This known effect is due to evolution rules with hereditary mechanism. The birth and death balance in the simulation game also leads to elimination of families specified by different genomes. The number of families G(t) versus time t follow the power law, G∝tn. Our results show the power coefficient exponent n is changing with time. Starting from about -1, smoothly achieves about -2 after hundreds of steps, and finally has semi-smooth transition to 0, when only one family exists in the environment. This is in contrast with constant n about -1 as found, for example, in Ref. 1. We suspect that this discrepancy may be due to two different time scales in simulations — initial stages follow the n ≈ -1 law, yet for large number of simulation steps we get n ≈ -2, provided the random initial population was sufficiently big to allow for still reliable statistical analysis. The n ≈ -1 evolution stage seems to be associated with the Verhulst mechanism of population elimination due to the limited environmental capacity — when the standard evolution rules were modified, we observed a plateau (n =0) in the power law in short time scale, again followed by n ≈ -2 law for longer times. The modified model uses birth rate controlled by the current population instead of the standard Verhulst death factor.

  7. Inverse scattering method and soliton double solution family for the general symplectic gravity model

    SciTech Connect

    Gao Yajun

    2008-08-15

    A previously established Hauser-Ernst-type extended double-complex linear system is slightly modified and used to develop an inverse scattering method for the stationary axisymmetric general symplectic gravity model. The reduction procedures in this inverse scattering method are found to be fairly simple, which makes the inverse scattering method applied fine and effective. As an application, a concrete family of soliton double solutions for the considered theory is obtained.

  8. Protein family and fold occurrence in genomes: power-law behaviour and evolutionary model.

    PubMed

    Qian, J; Luscombe, N M; Gerstein, M

    2001-11-01

    Global surveys of genomes measure the usage of essential molecular parts, defined here as protein families, superfamilies or folds, in different organisms. Based on surveys of the first 20 completely sequenced genomes, we observe that the occurrence of these parts follows a power-law distribution. That is, the number of distinct parts (F) with a given genomic occurrence (V) decays as F=aV(-b), with a few parts occurring many times and most occurring infrequently. For a given organism, the distributions of families, superfamilies and folds are nearly identical, and this is reflected in the size of the decay exponent b. Moreover, the exponent varies between different organisms, with those of smaller genomes displaying a steeper decay (i.e. larger b). Clearly, the power law indicates a preference to duplicate genes that encode for molecular parts which are already common. Here, we present a minimal, but biologically meaningful model that accurately describes the observed power law. Although the model performs equally well for all three protein classes, we focus on the occurrence of folds in preference to families and superfamilies. This is because folds are comparatively insensitive to the effects of point mutations that can cause a family member to diverge beyond detectable similarity. In the model, genomes evolve through two basic operations: (i) duplication of existing genes; (ii) net flow of new genes. The flow term is closely related to the exponent b and can accommodate considerable gene loss; however, we demonstrate that the observed data is reproduced best with a net inflow, i.e. with more gene gain than loss. Moreover, we show that prokaryotes have much higher rates of gene acquisition than eukaryotes, probably reflecting lateral transfer. A further natural outcome from our model is an estimation of the fold composition of the initial genome, which potentially relates to the common ancestor for modern organisms. Supplementary material pertaining to this work

  9. Toward a Stress Process Model of Children’s Exposure to Physical Family and Community Violence

    PubMed Central

    Brooks-Gunn, Jeanne

    2011-01-01

    Theoretically informed models are required to further the comprehensive understanding of children’s ETV. We draw on the stress process paradigm to forward an overall conceptual model of ETV (ETV) in childhood and adolescence. Around this conceptual model, we synthesize research in four dominant areas of the literature which are detailed but often disconnected including: (1) exposure to three forms of physical violence (e.g., child physical maltreatment, interparental violence, and community ETV); (2) the multilevel correlates and causes of ETV (e.g., neighborhood characteristics including concentrated disadvantage; family characteristics including socio-economic status and family stressors); (3) a range of consequences of ETV (e.g., internalizing and externalizing mental health problems, role transitions, and academic outcomes); and (4) multilevel and cross domain mediators and moderators of ETV influences (e.g., school and community factors, family social support, and individual coping resources). We highlight the range of interconnected processes through which violence exposures may influence children and suggest opportunities for prevention and intervention. We further identify needed future research on children’s ETV including coping resources as well as research on cumulative contributions of violence exposure, violence exposure modifications, curvilinearity, and timing of exposure. PMID:19434492

  10. Toward a stress process model of children's exposure to physical family and community violence.

    PubMed

    Foster, Holly; Brooks-Gunn, Jeanne

    2009-06-01

    Theoretically informed models are required to further the comprehensive understanding of children's ETV. We draw on the stress process paradigm to forward an overall conceptual model of ETV (ETV) in childhood and adolescence. Around this conceptual model, we synthesize research in four dominant areas of the literature which are detailed but often disconnected including: (1) exposure to three forms of physical violence (e.g., child physical maltreatment, interparental violence, and community ETV); (2) the multilevel correlates and causes of ETV (e.g., neighborhood characteristics including concentrated disadvantage; family characteristics including socio-economic status and family stressors); (3) a range of consequences of ETV (e.g., internalizing and externalizing mental health problems, role transitions, and academic outcomes); and (4) multilevel and cross domain mediators and moderators of ETV influences (e.g., school and community factors, family social support, and individual coping resources). We highlight the range of interconnected processes through which violence exposures may influence children and suggest opportunities for prevention and intervention. We further identify needed future research on children's ETV including coping resources as well as research on cumulative contributions of violence exposure, violence exposure modifications, curvilinearity, and timing of exposure. PMID:19434492