Science.gov

Sample records for blm exhibit divergent

  1. Chimpanzees and bonobos exhibit divergent spatial memory development.

    PubMed

    Rosati, Alexandra G; Hare, Brian

    2012-11-01

    Spatial cognition and memory are critical cognitive skills underlying foraging behaviors for all primates. While the emergence of these skills has been the focus of much research on human children, little is known about ontogenetic patterns shaping spatial cognition in other species. Comparative developmental studies of nonhuman apes can illuminate which aspects of human spatial development are shared with other primates, versus which aspects are unique to our lineage. Here we present three studies examining spatial memory development in our closest living relatives, chimpanzees (Pan troglodytes) and bonobos (P. paniscus). We first compared memory in a naturalistic foraging task where apes had to recall the location of resources hidden in a large outdoor enclosure with a variety of landmarks (Studies 1 and 2). We then compared older apes using a matched memory choice paradigm (Study 3). We found that chimpanzees exhibited more accurate spatial memory than bonobos across contexts, supporting predictions from these species' different feeding ecologies. Furthermore, chimpanzees - but not bonobos - showed developmental improvements in spatial memory, indicating that bonobos exhibit cognitive paedomorphism (delays in developmental timing) in their spatial abilities relative to chimpanzees. Together, these results indicate that the development of spatial memory may differ even between closely related species. Moreover, changes in the spatial domain can emerge during nonhuman ape ontogeny, much like some changes seen in human children. PMID:23106738

  2. Trophic niche divergence among colour morphs that exhibit alternative mating tactics

    PubMed Central

    Lattanzio, Matthew S.; Miles, Donald B.

    2016-01-01

    Discrete colour morphs associated with alternative mating tactics are assumed to be ecologically equivalent. Yet suites of behaviours linked with reproduction can also favour habitat segregation and exploitation of different prey among morphs. By contrast, trophic polymorphisms are usually attributed to morphs exhibiting habitat or prey selectivity. An alternative hypothesis is that habitat variation generates a trophic polymorphism driven by differences in morph reproductive behaviour, the spatial dispersion of morphs in a landscape and their exposure to different prey types. In this scenario, morphs are allowed to vary in habitat or diet selectivity (e.g. specialist or generalist) as they do in behaviour, rather than being assumed to exhibit equivalent levels of ecological specialization. We test this hypothesis using male Urosaurus ornatus lizards that exhibit a discrete dewlap colour polymorphism that reflects alternative mating tactics. We found blue morphs specialize on prey at higher trophic levels, yellow males display plasticity in trophic and morphological attributes and orange males are trophic generalists. Our results also demonstrate that morph diet differences are enhanced in resource-limited habitats. We conclude that discrete behavioural morphs may also diverge in morphology and trophic niche. Jointly, these processes may enhance speciation rates in colour polymorphic taxa. PMID:27152203

  3. Trophic niche divergence among colour morphs that exhibit alternative mating tactics.

    PubMed

    Lattanzio, Matthew S; Miles, Donald B

    2016-04-01

    Discrete colour morphs associated with alternative mating tactics are assumed to be ecologically equivalent. Yet suites of behaviours linked with reproduction can also favour habitat segregation and exploitation of different prey among morphs. By contrast, trophic polymorphisms are usually attributed to morphs exhibiting habitat or prey selectivity. An alternative hypothesis is that habitat variation generates a trophic polymorphism driven by differences in morph reproductive behaviour, the spatial dispersion of morphs in a landscape and their exposure to different prey types. In this scenario, morphs are allowed to vary in habitat or diet selectivity (e.g. specialist or generalist) as they do in behaviour, rather than being assumed to exhibit equivalent levels of ecological specialization. We test this hypothesis using male Urosaurus ornatus lizards that exhibit a discrete dewlap colour polymorphism that reflects alternative mating tactics. We found blue morphs specialize on prey at higher trophic levels, yellow males display plasticity in trophic and morphological attributes and orange males are trophic generalists. Our results also demonstrate that morph diet differences are enhanced in resource-limited habitats. We conclude that discrete behavioural morphs may also diverge in morphology and trophic niche. Jointly, these processes may enhance speciation rates in colour polymorphic taxa. PMID:27152203

  4. Gut Symbionts from Distinct Hosts Exhibit Genotoxic Activity via Divergent Colibactin Biosynthesis Pathways

    PubMed Central

    Vizcaino, Maria I.; Crawford, Jason M.

    2014-01-01

    Secondary metabolites produced by nonribosomal peptide synthetase (NRPS) or polyketide synthase (PKS) pathways are chemical mediators of microbial interactions in diverse environments. However, little is known about their distribution, evolution, and functional roles in bacterial symbionts associated with animals. A prominent example is colibactin, a largely unknown family of secondary metabolites produced by Escherichia coli via a hybrid NRPS-PKS biosynthetic pathway that inflicts DNA damage upon eukaryotic cells and contributes to colorectal cancer and tumor formation in the mammalian gut. Thus far, homologs of this pathway have only been found in closely related Enterobacteriaceae, while a divergent variant of this gene cluster was recently discovered in a marine alphaproteobacterial Pseudovibrio strain. Herein, we sequenced the genome of Frischella perrara PEB0191, a bacterial gut symbiont of honey bees and identified a homologous colibactin biosynthetic pathway related to those found in Enterobacteriaceae. We show that the colibactin genomic island (GI) has conserved gene synteny and biosynthetic module architecture across F. perrara, Enterobacteriaceae, and the Pseudovibrio strain. Comparative metabolomics analyses of F. perrara and E. coli further reveal that these two bacteria produce related colibactin pathway-dependent metabolites. Finally, we demonstrate that F. perrara, like E. coli, causes DNA damage in eukaryotic cells in vitro in a colibactin pathway-dependent manner. Together, these results support that divergent variants of the colibactin biosynthetic pathway are widely distributed among bacterial symbionts, producing related secondary metabolites and likely endowing its producer with functional capabilities important for diverse symbiotic associations. PMID:25527542

  5. MYB31/MYB42 Syntelogs Exhibit Divergent Regulation of Phenylpropanoid Genes in Maize, Sorghum and Rice.

    PubMed

    Agarwal, Tina; Grotewold, Erich; Doseff, Andrea I; Gray, John

    2016-01-01

    ZmMYB31 and ZmMYB42 are R2R3-MYB transcription factors implicated in the regulation of phenylpropanoid genes in maize. Here, we tested the hypothesis that the regulatory function of MYB31 and MYB42 is conserved in other monocots, specifically in sorghum and rice. We demonstrate that syntelogs of MYB31 and MYB42 do bind to phenylpropanoid genes that function in all stages of the pathway and in different tissues along the developmental gradient of seedling leaves. We found that caffeic acid O-methyltransferase (COMT1) is a common target of MYB31 and MYB42 in the mature leaf tissues of maize, sorghum and rice, as evidenced by Chromatin immunoprecipitation (ChIP) experiments. In contrast, 4-coumarate-CoA ligase (4CL2), ferulate-5-hydroxylase (F5H), and caffeoyl shikimate esterase (CSE), were targeted by MYB31 or MYB42, but in a more species-specific fashion. Our results revealed MYB31 and MYB42 participation in auto- and cross-regulation in all three species. Apart from a limited conservation of regulatory modules, MYB31 and MYB42 syntelogs appear to have undergone subfunctionalization following gene duplication and divergence of maize, sorghum, and rice. Elucidating the different regulatory roles of these syntelogs in the context of positive transcriptional activators may help guide attempts to alter the flux of intermediates towards lignin production in biofuel grasses. PMID:27328708

  6. MYB31/MYB42 Syntelogs Exhibit Divergent Regulation of Phenylpropanoid Genes in Maize, Sorghum and Rice

    PubMed Central

    Agarwal, Tina; Grotewold, Erich; Doseff, Andrea I.; Gray, John

    2016-01-01

    ZmMYB31 and ZmMYB42 are R2R3-MYB transcription factors implicated in the regulation of phenylpropanoid genes in maize. Here, we tested the hypothesis that the regulatory function of MYB31 and MYB42 is conserved in other monocots, specifically in sorghum and rice. We demonstrate that syntelogs of MYB31 and MYB42 do bind to phenylpropanoid genes that function in all stages of the pathway and in different tissues along the developmental gradient of seedling leaves. We found that caffeic acid O-methyltransferase (COMT1) is a common target of MYB31 and MYB42 in the mature leaf tissues of maize, sorghum and rice, as evidenced by Chromatin immunoprecipitation (ChIP) experiments. In contrast, 4-coumarate-CoA ligase (4CL2), ferulate-5-hydroxylase (F5H), and caffeoyl shikimate esterase (CSE), were targeted by MYB31 or MYB42, but in a more species-specific fashion. Our results revealed MYB31 and MYB42 participation in auto- and cross-regulation in all three species. Apart from a limited conservation of regulatory modules, MYB31 and MYB42 syntelogs appear to have undergone subfunctionalization following gene duplication and divergence of maize, sorghum, and rice. Elucidating the different regulatory roles of these syntelogs in the context of positive transcriptional activators may help guide attempts to alter the flux of intermediates towards lignin production in biofuel grasses. PMID:27328708

  7. Comparison of stem morphology and anatomy of two alfalfa clonal lines exhibiting divergent cell wall composition

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In previous research, two alfalfa clonal lines (252, 1283) were identified that exhibited environmentally stable differences in stem cell walls. Compared to stems of 1283, stems of 252 have a higher cell wall concentration and greater amounts of lignin and cellulose but reduced levels of pectic suga...

  8. HIV-1 and HIV-2 exhibit divergent interactions with HLTF and UNG2 DNA repair proteins.

    PubMed

    Hrecka, Kasia; Hao, Caili; Shun, Ming-Chieh; Kaur, Sarabpreet; Swanson, Selene K; Florens, Laurence; Washburn, Michael P; Skowronski, Jacek

    2016-07-01

    HIV replication in nondividing host cells occurs in the presence of high concentrations of noncanonical dUTP, apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3 (APOBEC3) cytidine deaminases, and SAMHD1 (a cell cycle-regulated dNTP triphosphohydrolase) dNTPase, which maintains low concentrations of canonical dNTPs in these cells. These conditions favor the introduction of marks of DNA damage into viral cDNA, and thereby prime it for processing by DNA repair enzymes. Accessory protein Vpr, found in all primate lentiviruses, and its HIV-2/simian immunodeficiency virus (SIV) SIVsm paralogue Vpx, hijack the CRL4(DCAF1) E3 ubiquitin ligase to alleviate some of these conditions, but the extent of their interactions with DNA repair proteins has not been thoroughly characterized. Here, we identify HLTF, a postreplication DNA repair helicase, as a common target of HIV-1/SIVcpz Vpr proteins. We show that HIV-1 Vpr reprograms CRL4(DCAF1) E3 to direct HLTF for proteasome-dependent degradation independent from previously reported Vpr interactions with base excision repair enzyme uracil DNA glycosylase (UNG2) and crossover junction endonuclease MUS81, which Vpr also directs for degradation via CRL4(DCAF1) E3. Thus, separate functions of HIV-1 Vpr usurp CRL4(DCAF1) E3 to remove key enzymes in three DNA repair pathways. In contrast, we find that HIV-2 Vpr is unable to efficiently program HLTF or UNG2 for degradation. Our findings reveal complex interactions between HIV-1 and the DNA repair machinery, suggesting that DNA repair plays important roles in the HIV-1 life cycle. The divergent interactions of HIV-1 and HIV-2 with DNA repair enzymes and SAMHD1 imply that these viruses use different strategies to guard their genomes and facilitate their replication in the host. PMID:27335459

  9. BLM Environmental Education National Strategy.

    ERIC Educational Resources Information Center

    Bureau of Land Management (Dept. of Interior), Washington, DC.

    This environmental education strategy was developed by a Bureau of Land Management (BLM) Washington Office Task Group in collaboration with staff at all levels of the BLM. The strategy calls for the BLM to expand its efforts in educating citizens about ecosystems and ecosystem management, and to establish environmental education as an integral…

  10. Ewes With Divergent Cortisol Responses to ACTH Exhibit Functional Differences in the Hypothalamo-Pituitary-Adrenal (HPA) Axis.

    PubMed

    Hewagalamulage, Sakda D; Clarke, Iain J; Rao, Alexandra; Henry, Belinda A

    2016-09-01

    Within any population, the cortisol response to ACTH covers a considerable range. High responders (HRs) exhibit a greater cortisol secretory response to stress or ACTH, compared with individuals classified as low cortisol responders (LRs). We administered ACTH (0.2 μg/kg, iv) to 160 female sheep and selected subpopulations of animals as LR and HR. In the present study, we aimed to characterize the hypothalamo-pituitary-adrenal axis in HR and LR and to identify factors that underlie the differing cortisol responses to ACTH. Hypothalami, pituitaries, and adrenals were collected from nonstressed HR and LR ewes. Expression of genes for CRH, arginine vasopressin (AVP), oxytocin, glucocorticoid receptor, and mineralocorticoid receptor were measured by in situ hybridization in the paraventricular nucleus of the hypothalamus, and proopiomelanocortin (POMC) gene expression was measured in the anterior pituitary. Expression of CRH, AVP, and POMC was higher in HR, with no differences in either glucocorticoid receptor or mineralocorticoid receptor expression. Oxytocin expression was greater in LR. In the adrenal gland, real-time PCR analysis indicated that expression of the ACTH receptor and a range of steroidogenic enzymes was similar in HR and LR. Adrenal weights, the cortex to medulla ratio and adrenal cortisol content were also similar in LR and HR. In conclusion, LR and HR display innate differences in the steady-state expression of CRH, AVP, oxytocin, and POMC, indicating that selection for cortisol responsiveness identifies distinct subpopulations that exhibit innate differences in the gene expression/function of hypothalamo-pituitary-adrenal axis markers. PMID:27414744

  11. DISTANT VIEW, BLM TACK SHED ON LEFT, BLM SEED SHED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    DISTANT VIEW, BLM TACK SHED ON LEFT, BLM SEED SHED AT LEFT CENTER, FIRE DISPATCH OFFICES 1 AND 2 AT RIGHT CENTER, UTILITY BUILDING "B" ON RIGHT. VIEW TO SOUTHWEST. - Cedar City Automotive Repair Shop, 820 North Main Street, Cedar City, Iron County, UT

  12. BLM protein mitigates formaldehyde-induced genomic instability

    PubMed Central

    Kumari, Anuradha; Owen, Nichole; Juarez, Eleonora; McCullough, Amanda K.

    2015-01-01

    Formaldehyde is a reactive aldehyde that has been classified as a class I human carcinogen by the International Agency for Cancer Research. There are growing concerns over the possible adverse health effects related to the occupational and environmental human exposures to formaldehyde. Although formaldehyde-induced DNA and protein adducts have been identified, the genomic instability mechanisms and the cellular tolerance pathways associated with formaldehyde exposure are not fully characterized. This study specifically examines the role of a genome stability protein, Bloom (BLM) in limiting formaldehyde-induced cellular and genetic abnormalities. Here, we show that in the absence of BLM protein, formaldehyde-treated cells exhibited increased cellular sensitivity, an immediate cell cycle arrest, and an accumulation of chromosome radial structures. In addition, live-cell imaging experiments demonstrated that formaldehyde-treated cells are dependent on BLM for timely segregation of daughter cells. Both wild-type and BLM-deficient formaldehyde-treated cells showed an accumulation of 53BP1 and γH2AX foci indicative of DNA double-strand breaks (DSBs); however, relative to wild-type cells, the BLM-deficient cells exhibited delayed repair. In response to formaldehyde exposure, we observed co-localization of 53BP1 and BLM foci at the DSB repair site, where ATM-dependent accumulation of formaldehyde-induced BLM foci occurred after the recruitment of 53BP1. Together, these findings highlight the significance of functional interactions among ATM, 53BP1, and BLM proteins as responders associated with the repair and tolerance mechanisms induced by formaldehyde. PMID:25770783

  13. MMS, BLM assessed

    NASA Astrophysics Data System (ADS)

    Richman, Barbara T.

    After reviewing the Department of the Interior's organizational structure for federal energy and minerals resource management, the U.S. General Accounting Office (GAO) concluded that the ‘accountability and management of minerals programs are weakened by the current split of responsibilities between the Bureau of Land Management [BLM] and Minerals Management Service [MMS].’ Moreover, ‘to facilitate efficient, comprehensive management of these resources and to clarify lines of authority and accountability,’ GAO recommends that ‘to the extent permitted by law’ Secretary of the Interior James Watt should ‘consolidate the department's onshore minerals management responsibilities in the Minerals Management Service.’Mineral management programs within BLM are fragmented, GAO says, which makes for difficult routine monitoring of program costs and results. ‘As major sources of federal receipts and domestic supplies of fuel and nonfuel minerals, these resource management programs require, but are lacking, clear lines of repsonsibility and organization for efficient operations and program review.’ However, MMS ‘has the potential to provide comprehensive management of these resources,’ GAO concludes.

  14. Three Homologous Genes Encoding sn-Glycerol-3-Phosphate Acyltransferase 4 Exhibit Different Expression Patterns and Functional Divergence in Brassica napus1[C][W][OA

    PubMed Central

    Chen, Xue; Truksa, Martin; Snyder, Crystal L.; El-Mezawy, Aliaa; Shah, Saleh; Weselake, Randall J.

    2011-01-01

    Brassica napus is an allotetraploid (AACC) formed from the fusion of two diploid progenitors, Brassica rapa (AA) and Brassica oleracea (CC). Polyploidy and genome-wide rearrangement during the evolution process have resulted in genes that are present as multiple homologs in the B. napus genome. In this study, three B. napus homologous genes encoding endoplasmic reticulum-bound sn-glycerol-3-phosphate acyltransferase 4 (GPAT4) were identified and characterized. Although the three GPAT4 homologs share a high sequence similarity, they exhibit different expression patterns and altered epigenetic features. Heterologous expression in yeast further revealed that the three BnGPAT4 homologs encoded functional GPAT enzymes but with different levels of polypeptide accumulation. Complementation of the Arabidopsis (Arabidopsis thaliana) gpat4 gpat8 double mutant line with individual BnGPAT4 homologs suggested their physiological roles in cuticle formation. Analysis of gpat4 RNA interference lines of B. napus revealed that the BnGPAT4 deficiency resulted in reduced cutin content and altered stomatal structures in leaves. Our results revealed that the BnGPAT4 homologs have evolved into functionally divergent forms and play important roles in cutin synthesis and stomatal development. PMID:21173024

  15. Overexpression of Three TaEXPA1 Homoeologous Genes with Distinct Expression Divergence in Hexaploid Wheat Exhibit Functional Retention in Arabidopsis

    PubMed Central

    Xing, Jiewen; Chen, Yanhong; Han, Zongfu; Yao, Yingyin; Peng, Huiru; Ni, Zhongfu; Sun, Qixin

    2013-01-01

    Common wheat is a hexaploid species with most of the genes present as triplicate homoeologs. Expression divergences of homoeologs are frequently observed in wheat as well as in other polyploid plants. However, little is known about functional variances among homologous genes arising from polyploidy. Expansins play diverse roles in plant developmental processes related to the action of cell wall loosening. Expression of the three TaEXPA1 homoeologs varied dynamically at different stages and organs, and epigenetic modifications contribute to the expression divergence of three TaEXPA1 homoeologs during wheat development. Nevertheless, their functions remain to be clarified. We found that over expression of TaEXPA1-A, -B and -D produced similar morphological changes in transgenic Arabidopsis plants, including increased germination and growth rate during seedling and adult stages, indicating that the proteins encoded by these three wheat TaEXPA1 homoeologs have similar (or conserved) functions in Arabidopsis. Collectively, our present study provided an example of a set of homoeologous genes expression divergence in different developmental stages and organs in hexaploid wheat but functional retention in transgenic Arabidopsis plants. PMID:23696842

  16. Bloom Syndrome Radials are Non-homologous and are Suppressed by Phosphorylated BLM

    PubMed Central

    Rennie, Scott; Mitchell, Asia; Newell, Amy Hanlon; Ziaie, Navid; Moses, Robb E.; Olson, Susan B.

    2015-01-01

    Biallelic mutations in BLM cause Bloom syndrome (BS), a genome instability disorder characterized by growth retardation, sun sensitivity and a predisposition to cancer. As evidence of decreased genome stability, BS cells demonstrate not only elevated levels of spontaneous sister chromatid exchanges (SCE), but also exhibit chromosomal radial formation. The molecular nature and mechanism of radial formation is not known, but they have been thought to be DNA recombination intermediates between homologs that failed to resolve. However, we find that radials in BS cells occur over 95% between non-homologous chromosomes, and occur non-randomly throughout the genome. BLM must be phosphorylated at T99 and T122 for certain cell cycle checkpoints, but it is not known whether these modifications are necessary to suppress radial formation. We find that exogenous BLM constructs preventing phosphorylation at T99 and T122 are not able to suppress radial formation in BS cells, but are able to inhibit SCE formation. These findings indicate that BLM functions in two distinct pathways requiring different modifications. In one pathway—for which the phosphorylation marks appear dispensable—BLM functions to suppress SCE formation. In a second pathway, T99 and T122 phosphorylation are essential for suppression of chromosomal radial formation, both those formed spontaneously and those formed following interstrand crosslink (ICL) damage. PMID:25766002

  17. 43 CFR 3192.10 - What costs will BLM pay?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... AGREEMENTS AND CONTRACTS FOR OIL AND GAS INSPECTION Cooperative Agreements § 3192.10 What costs will BLM pay... Cost Principles for Assistance Programs, of this title. (b) BLM will fund the agreements up to...

  18. 43 CFR 3192.10 - What costs will BLM pay?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... AGREEMENTS AND CONTRACTS FOR OIL AND GAS INSPECTION Cooperative Agreements § 3192.10 What costs will BLM pay... Cost Principles for Assistance Programs, of this title. (b) BLM will fund the agreements up to...

  19. 43 CFR 3192.10 - What costs will BLM pay?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... AGREEMENTS AND CONTRACTS FOR OIL AND GAS INSPECTION Cooperative Agreements § 3192.10 What costs will BLM pay... Cost Principles for Assistance Programs, of this title. (b) BLM will fund the agreements up to...

  20. 43 CFR 3809.10 - How does BLM classify operations?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false How does BLM classify operations? 3809.10 Section 3809.10 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND... Surface Management General Information § 3809.10 How does BLM classify operations? BLM...

  1. 43 CFR 3809.10 - How does BLM classify operations?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false How does BLM classify operations? 3809.10 Section 3809.10 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND... Surface Management General Information § 3809.10 How does BLM classify operations? BLM...

  2. 43 CFR 3809.10 - How does BLM classify operations?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false How does BLM classify operations? 3809.10 Section 3809.10 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND... Surface Management General Information § 3809.10 How does BLM classify operations? BLM...

  3. 43 CFR 3809.10 - How does BLM classify operations?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false How does BLM classify operations? 3809.10 Section 3809.10 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND... Surface Management General Information § 3809.10 How does BLM classify operations? BLM...

  4. BLM Core Terrestrial Indicators and Methods

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The Bureau of Land Management (BLM) Assessment, Inventory, and Monitoring (AIM) Strategy was initiated, in part, to evaluate current monitoring activities and recommend procedures to improve the efficiency and effectiveness of these activities. To this end, the AIM Strategy supports an integrated ap...

  5. 43 CFR 4300.54 - Can BLM increase the size of the land in my permit?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... ADMINISTRATION; ALASKA; REINDEER; GENERAL Changes in the Size of the Permit Area § 4300.54 Can BLM increase the... if BLM determines that the area is too small for the number of reindeer you are grazing. BLM...

  6. 43 CFR 4300.54 - Can BLM increase the size of the land in my permit?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ADMINISTRATION; ALASKA; REINDEER; GENERAL Changes in the Size of the Permit Area § 4300.54 Can BLM increase the... if BLM determines that the area is too small for the number of reindeer you are grazing. BLM...

  7. 43 CFR 4300.54 - Can BLM increase the size of the land in my permit?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... ADMINISTRATION; ALASKA; REINDEER; GENERAL Changes in the Size of the Permit Area § 4300.54 Can BLM increase the... if BLM determines that the area is too small for the number of reindeer you are grazing. BLM...

  8. 43 CFR 4300.54 - Can BLM increase the size of the land in my permit?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ADMINISTRATION; ALASKA; REINDEER; GENERAL Changes in the Size of the Permit Area § 4300.54 Can BLM increase the... if BLM determines that the area is too small for the number of reindeer you are grazing. BLM...

  9. 43 CFR 1821.10 - Where are BLM offices located?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Where are BLM offices located? 1821.10 Section 1821.10 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR GENERAL MANAGEMENT (1000) APPLICATION PROCEDURES General Information § 1821.10 Where are BLM offices located?...

  10. 43 CFR 1821.10 - Where are BLM offices located?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Where are BLM offices located? 1821.10 Section 1821.10 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR GENERAL MANAGEMENT (1000) APPLICATION PROCEDURES General Information § 1821.10 Where are BLM offices located?...

  11. Enhanced Tumor Formation in Mice Heterozygous for Blm Mutation

    NASA Astrophysics Data System (ADS)

    Heppner Goss, Kathleen; Risinger, Mary A.; Kordich, Jennifer J.; Sanz, Maureen M.; Straughen, Joel E.; Slovek, Lisa E.; Capobianco, Anthony J.; German, James; Boivin, Gregory P.; Groden, Joanna

    2002-09-01

    Persons with the autosomal recessive disorder Bloom syndrome are predisposed to cancers of many types due to loss-of-function mutations in the BLM gene, which encodes a recQ-like helicase. Here we show that mice heterozygous for a targeted null mutation of Blm, the murine homolog of BLM, develop lymphoma earlier than wild-type littermates in response to challenge with murine leukemia virus and develop twice the number of intestinal tumors when crossed with mice carrying a mutation in the Apctumor suppressor. These observations indicate that Blm is a modifier of tumor formation in the mouse and that Blm haploinsufficiency is associated with tumor predisposition, a finding with important implications for cancer risk in humans.

  12. 43 CFR 2806.32 - How does BLM determine the population strata served?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false How does BLM determine the population... does BLM determine the population strata served? (a) BLM determines the population strata served as follows: (1) If the site or facility is within a designated RMA, BLM will use the population strata of...

  13. 43 CFR 2806.32 - How does BLM determine the population strata served?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false How does BLM determine the population... does BLM determine the population strata served? (a) BLM determines the population strata served as follows: (1) If the site or facility is within a designated RMA, BLM will use the population strata of...

  14. 43 CFR 2806.32 - How does BLM determine the population strata served?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false How does BLM determine the population... does BLM determine the population strata served? (a) BLM determines the population strata served as follows: (1) If the site or facility is within a designated RMA, BLM will use the population strata of...

  15. 43 CFR 2806.32 - How does BLM determine the population strata served?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false How does BLM determine the population... does BLM determine the population strata served? (a) BLM determines the population strata served as follows: (1) If the site or facility is within a designated RMA, BLM will use the population strata of...

  16. 43 CFR 6301.3 - What is a BLM wilderness area?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false What is a BLM wilderness area? 6301.3... WILDERNESS AREAS Introduction § 6301.3 What is a BLM wilderness area? A BLM wilderness area is an area of public lands that Congress has designated for BLM to manage as a component of the National...

  17. 43 CFR 6301.3 - What is a BLM wilderness area?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false What is a BLM wilderness area? 6301.3... WILDERNESS AREAS Introduction § 6301.3 What is a BLM wilderness area? A BLM wilderness area is an area of public lands that Congress has designated for BLM to manage as a component of the National...

  18. 43 CFR 6301.3 - What is a BLM wilderness area?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false What is a BLM wilderness area? 6301.3... WILDERNESS AREAS Introduction § 6301.3 What is a BLM wilderness area? A BLM wilderness area is an area of public lands that Congress has designated for BLM to manage as a component of the National...

  19. 43 CFR 6301.3 - What is a BLM wilderness area?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false What is a BLM wilderness area? 6301.3... WILDERNESS AREAS Introduction § 6301.3 What is a BLM wilderness area? A BLM wilderness area is an area of public lands that Congress has designated for BLM to manage as a component of the National...

  20. Semihard processes with BLM renormalization scale setting

    SciTech Connect

    Caporale, Francesco; Murdaca, Beatrice; Papa, Alessandro

    2015-04-10

    We apply the BLM scale setting procedure directly to amplitudes (cross sections) of several semihard processes. It is shown that, due to the presence of β{sub 0}-terms in the NLA results for the impact factors, the obtained optimal renormalization scale is not universal, but depends both on the energy and on the process in question. We illustrate this general conclusion considering the following semihard processes: (i) inclusive production of two forward high-p{sub T} jets separated by large interval in rapidity (Mueller-Navelet jets); (ii) high-energy behavior of the total cross section for highly virtual photons; (iii) forward amplitude of the production of two light vector mesons in the collision of two virtual photons.

  1. 43 CFR 2568.111 - What if BLM decides that I qualify for land that is in the category of Federal land that BLM...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false What if BLM decides that I qualify for land that is in the category of Federal land that BLM cannot convey? 2568.111 Section 2568.111 Public... Certain Veterans Alternative Allotments § 2568.111 What if BLM decides that I qualify for land that is...

  2. 43 CFR 2568.111 - What if BLM decides that I qualify for land that is in the category of Federal land that BLM...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false What if BLM decides that I qualify for land that is in the category of Federal land that BLM cannot convey? 2568.111 Section 2568.111 Public... Certain Veterans Alternative Allotments § 2568.111 What if BLM decides that I qualify for land that is...

  3. Outdoor Exhibits

    NASA Technical Reports Server (NTRS)

    1996-01-01

    The National Data Buoy Center (NDBC) at the John C. Stennis Space Center has exhibits located in front of the Visitors Center. These boat-shaped buoys are moored in areas of the ocean that experience hostile environmental conditions. The instruments installed gather information and relay it to the National Weather Service by satellite. Nomad buoys are 20 feet long and weigh 13,900 pounds. They provide information on wind speed and direction, humidity levels, air and sea surface temperature and air pressure. U.S. Coast Guard ships transport buoys to their mooring sites.

  4. 43 CFR 3255.12 - How long will information I give BLM remain confidential or proprietary?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... information I give BLM remain confidential or proprietary? The FOIA (5 U.S.C. 552) does not provide a finite period of time during which information may be exempt from public disclosure. BLM will review...

  5. 43 CFR 3255.12 - How long will information I give BLM remain confidential or proprietary?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... information I give BLM remain confidential or proprietary? The FOIA (5 U.S.C. 552) does not provide a finite period of time during which information may be exempt from public disclosure. BLM will review...

  6. 43 CFR 3255.12 - How long will information I give BLM remain confidential or proprietary?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... information I give BLM remain confidential or proprietary? The FOIA (5 U.S.C. 552) does not provide a finite period of time during which information may be exempt from public disclosure. BLM will review...

  7. 43 CFR 3255.12 - How long will information I give BLM remain confidential or proprietary?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... information I give BLM remain confidential or proprietary? The FOIA (5 U.S.C. 552) does not provide a finite period of time during which information may be exempt from public disclosure. BLM will review...

  8. 43 CFR 3206.14 - How does BLM compute acreage holdings?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false How does BLM compute acreage holdings? 3206.14 Section 3206.14 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU... Lease Issuance § 3206.14 How does BLM compute acreage holdings? BLM computes acreage holdings as...

  9. 43 CFR 3206.14 - How does BLM compute acreage holdings?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false How does BLM compute acreage holdings? 3206.14 Section 3206.14 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU... Lease Issuance § 3206.14 How does BLM compute acreage holdings? BLM computes acreage holdings as...

  10. 43 CFR 3206.14 - How does BLM compute acreage holdings?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false How does BLM compute acreage holdings? 3206.14 Section 3206.14 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU... Lease Issuance § 3206.14 How does BLM compute acreage holdings? BLM computes acreage holdings as...

  11. 43 CFR 3206.14 - How does BLM compute acreage holdings?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false How does BLM compute acreage holdings? 3206.14 Section 3206.14 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU... Lease Issuance § 3206.14 How does BLM compute acreage holdings? BLM computes acreage holdings as...

  12. 43 CFR 3137.24 - Why would BLM reject a unit agreement application?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Why would BLM reject a unit agreement application? 3137.24 Section 3137.24 Public Lands: Interior Regulations Relating to Public Lands (Continued... § 3137.24 Why would BLM reject a unit agreement application? BLM will reject a unit agreement...

  13. 43 CFR 3214.14 - May BLM increase the bond amount above the minimum?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... minimum? 3214.14 Section 3214.14 Public Lands: Interior Regulations Relating to Public Lands (Continued... LEASING Personal and Surety Bonds § 3214.14 May BLM increase the bond amount above the minimum? (a) BLM... surface in a timely manner; (3) MMS has notified BLM that a person covered by the bond owes...

  14. 43 CFR 3216.22 - Does BLM approve all transfer requests?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Does BLM approve all transfer requests? 3216.22 Section 3216.22 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU... Transfers § 3216.22 Does BLM approve all transfer requests? BLM will not approve a transfer if: (a)...

  15. 43 CFR 3216.22 - Does BLM approve all transfer requests?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Does BLM approve all transfer requests? 3216.22 Section 3216.22 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU... Transfers § 3216.22 Does BLM approve all transfer requests? BLM will not approve a transfer if: (a)...

  16. 43 CFR 3216.22 - Does BLM approve all transfer requests?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Does BLM approve all transfer requests? 3216.22 Section 3216.22 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU... Transfers § 3216.22 Does BLM approve all transfer requests? BLM will not approve a transfer if: (a)...

  17. 43 CFR 3216.22 - Does BLM approve all transfer requests?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Does BLM approve all transfer requests? 3216.22 Section 3216.22 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU... Transfers § 3216.22 Does BLM approve all transfer requests? BLM will not approve a transfer if: (a)...

  18. 43 CFR 3217.14 - When will BLM approve my drilling or development contract?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false When will BLM approve my drilling or... RESOURCE LEASING Cooperative Agreements § 3217.14 When will BLM approve my drilling or development contract? BLM may approve a drilling or development contract when: (a) One or more geothermal lessees enter...

  19. 43 CFR 3217.14 - When will BLM approve my drilling or development contract?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false When will BLM approve my drilling or... RESOURCE LEASING Cooperative Agreements § 3217.14 When will BLM approve my drilling or development contract? BLM may approve a drilling or development contract when: (a) One or more geothermal lessees enter...

  20. 43 CFR 3809.311 - What action does BLM take when it receives my notice?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false What action does BLM take when it receives... action does BLM take when it receives my notice? (a) Upon receipt of your notice, BLM will review it within 15 calendar days to see if it is complete under § 3809.301. (b) If your notice is incomplete,...

  1. 43 CFR 3809.311 - What action does BLM take when it receives my notice?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false What action does BLM take when it receives... action does BLM take when it receives my notice? (a) Upon receipt of your notice, BLM will review it within 15 calendar days to see if it is complete under § 3809.301. (b) If your notice is incomplete,...

  2. 43 CFR 3809.311 - What action does BLM take when it receives my notice?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false What action does BLM take when it receives... action does BLM take when it receives my notice? (a) Upon receipt of your notice, BLM will review it within 15 calendar days to see if it is complete under § 3809.301. (b) If your notice is incomplete,...

  3. 43 CFR 3809.311 - What action does BLM take when it receives my notice?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false What action does BLM take when it receives... action does BLM take when it receives my notice? (a) Upon receipt of your notice, BLM will review it within 15 calendar days to see if it is complete under § 3809.301. (b) If your notice is incomplete,...

  4. 43 CFR 2806.11 - How will BLM charge me rent?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false How will BLM charge me rent? 2806.11 Section 2806.11 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND... POLICY MANAGEMENT ACT Rents General Provisions § 2806.11 How will BLM charge me rent? (a) BLM will...

  5. 43 CFR 2806.11 - How will BLM charge me rent?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false How will BLM charge me rent? 2806.11 Section 2806.11 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND... POLICY MANAGEMENT ACT Rents General Provisions § 2806.11 How will BLM charge me rent? (a) BLM will...

  6. 43 CFR 2806.11 - How will BLM charge me rent?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false How will BLM charge me rent? 2806.11 Section 2806.11 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND... POLICY MANAGEMENT ACT Rents General Provisions § 2806.11 How will BLM charge me rent? (a) BLM will...

  7. 43 CFR 2802.11 - How does BLM designate corridors?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... MANAGEMENT, DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) RIGHTS-OF-WAY UNDER THE FEDERAL LAND POLICY MANAGEMENT ACT Lands Available for FLPMA Grants § 2802.11 How does BLM designate corridors? (a..., concerns, and needs. The process results in a resource management plan or plan amendment, which...

  8. 43 CFR 3192.10 - What costs will BLM pay?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false What costs will BLM pay? 3192.10 Section 3192.10 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) DELEGATION OF AUTHORITY, COOPERATIVE AGREEMENTS AND CONTRACTS FOR OIL AND GAS...

  9. Chimpanzees and Bonobos Exhibit Divergent Spatial Memory Development

    ERIC Educational Resources Information Center

    Rosati, Alexandra G.; Hare, Brian

    2012-01-01

    Spatial cognition and memory are critical cognitive skills underlying foraging behaviors for all primates. While the emergence of these skills has been the focus of much research on human children, little is known about ontogenetic patterns shaping spatial cognition in other species. Comparative developmental studies of nonhuman apes can…

  10. 77 FR 71822 - Notice of Availability of the BLM's Responses to Public Comments and of the BLM's Environmental...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-04

    ..., 2012, 77 FR 41442. This Notice announces the availability of the Bureau of Land Management's (BLM... this area and has been mined since 1930. The Secretary issued the first Potash Order in 1939 (4 FR 1012... with development of the other (16 FR 10669, October 18, 1951). The Order was amended in 1965 (30...

  11. 78 FR 29379 - BLM Director's Response to the Appeal by the Governors of Utah and Wyoming of the BLM Assistant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-20

    ...) for Allocation of Oil Shale and Tar Sands Resources on Lands Administered by the Bureau of Land... for Allocation of Oil Shale and Tar Sands Resources on Lands Administered by the BLM in Colorado, Utah... version of Alternative 2(b) from the proposed plan in the Final Oil Shale and Tar Sands...

  12. 78 FR 68466 - BLM Director's Response to the Idaho Governor's Appeal of the BLM Idaho State Director's Governor...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-14

    ... Sage-Grouse Plan concerns, your letter did not identify inconsistencies between your Plan and any of... regulatory requirements by specifically identifying inconsistencies between the Greater Sage-Grouse Plan and... of BLM Idaho's statement that your Greater Sage-Grouse Plan was `not sufficiently final' to...

  13. 78 FR 4435 - BLM Director's Response to the Alaska Governor's Appeal of the BLM Alaska State Director's...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-22

    ... Finding ] of No Significant Impact for the Delta River Special Recreation Management Area (SRMA) Plan and... business hours. A copy of the Delta River SRMA Plan and EARMP are available on the BLM-Alaska Web site at... Assessment (EA) and Finding of No Significant Impact for the Delta River SRMA Plan and the EARMP...

  14. Early phase pharmacokinetics and pulmonary disposition of parenteral bleomycin A2 (BLM A2) in BLM sensitive and resistant strains of mice

    SciTech Connect

    Harrison, J.H.; Filderman, A.E.; Lazo, J.S.

    1986-03-01

    Recent studies have shown that C57BL/6N mice are more sensitive than BALB/c mice to the pulmonary fibrotic effects of BLM. To determine whether the two strains show corresponding differences in BLM pharmacokinetics and pulmonary disposition after parenteral injection, the authors treated C57BL/6N and BALB/c mice with a single dose of (/sup 3/H)-BLM (80 mg/kg,iv). Serial blood samples were collected over 30 min from each animal, followed by pulmonary lavage and collection organs. In C57 BL/6N mice, BLM A2 plasma levels were maximal (178-227 ..mu..g/ml) in the first sample (2 min) and declined in a first order manner with a half-life of 12.6 +/- 3.6 (SD) min. The Vd was 232 +/- 29 ml/kg body weight. Pulmonary lavage recovered 68.1 +/- 3.5% of total lung radioactivity. BLM A2 was the predominant radioactive species and was present in equal proportions in lavage fluid and lung tissue. BALB/c mice showed similar BLM A2 distribution and elimination, and the recovery of BLM A2 in lavage fluid was not decreased as compared with C57BL/6N mice. Therefore, the resistance of BALB/c mice to BLM pulmonary toxicity does not appear to result from enhanced elimination of the drug or relative exclusion of BLM from lung tissues at this dose. These findings indicate that after iv injection, BLM rapidly distributes through a volume similar to extracellular water and, of particular interest, the majority of lung BLM is accessible to pulmonary lavage.

  15. Quantum skew divergence

    SciTech Connect

    Audenaert, Koenraad M. R.

    2014-11-15

    In this paper, we study the quantum generalisation of the skew divergence, which is a dissimilarity measure between distributions introduced by Lee in the context of natural language processing. We provide an in-depth study of the quantum skew divergence, including its relation to other state distinguishability measures. Finally, we present a number of important applications: new continuity inequalities for the quantum Jensen-Shannon divergence and the Holevo information, and a new and short proof of Bravyi's Small Incremental Mixing conjecture.

  16. 43 CFR 3254.11 - What will BLM do if my exploration operations are not in compliance with my permit, other BLM...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false What will BLM do if my exploration operations are not in compliance with my permit, other BLM approvals or orders, or the regulations in this part? 3254.11 Section 3254.11 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF...

  17. Development of a BLM-based intelligent biosensor

    NASA Astrophysics Data System (ADS)

    Liu, Sheng; Wei, Yunlong; Cai, Shaoxi; Tien, H. Ti; Ottova, Angelica L.

    2001-09-01

    Bilayer lipid membranes (BLMs) are promising 'smart' materials for biosensor and biomolecules. A novel pH-microbe of an acupuncture needle support with BLM modified by electron mediators was fabricated. An intelligent biosensor system BLM-based was developed. The intelligent system can automatically measure and analyze pH value of aqueous solution with probes BLMs-based and Si-chips thin-film as sensing elements. It can also give a warning message when the pH value of aqueous solution is over one threshold value. The intelligent system has communication interface of computer. A monitoring system based network can be constructed by connection the intelligence system with computers.

  18. Primate molecular divergence dates.

    PubMed

    Steiper, Michael E; Young, Nathan M

    2006-11-01

    With genomic data, alignments can be assembled that greatly increase the number of informative sites for analysis of molecular divergence dates. Here, we present an estimate of the molecular divergence dates for all of the major primate groups. These date estimates are based on a Bayesian analysis of approximately 59.8 kbp of genomic data from 13 primates and 6 mammalian outgroups, using a range of paleontologically supported calibration estimates. Results support a Cretaceous last common ancestor of extant primates (approximately 77 mya), an Eocene divergence between platyrrhine and catarrhine primates (approximately 43 mya), an Oligocene origin of apes and Old World monkeys (approximately 31 mya), and an early Miocene (approximately 18 mya) divergence of Asian and African great apes. These dates are examined in the context of other molecular clock studies. PMID:16815047

  19. Transcriptomic and Protein Expression Analysis Reveals Clinicopathological Significance of Bloom Syndrome Helicase (BLM) in Breast Cancer.

    PubMed

    Arora, Arvind; Abdel-Fatah, Tarek M A; Agarwal, Devika; Doherty, Rachel; Moseley, Paul M; Aleskandarany, Mohammed A; Green, Andrew R; Ball, Graham; Alshareeda, Alaa T; Rakha, Emad A; Chan, Stephen Y T; Ellis, Ian O; Madhusudan, Srinivasan

    2015-04-01

    Bloom syndrome helicase (BLM) has key roles in homologous recombination repair, telomere maintenance, and DNA replication. Germ-line mutations in the BLM gene causes Bloom syndrome, a rare disorder characterized by premature aging and predisposition to multiple cancers, including breast cancer. The clinicopathologic significance of BLM in sporadic breast cancers is unknown. We investigated BLM mRNA expression in the Molecular Taxonomy of Breast Cancer International Consortium cohort (n = 1,950) and validated in an external dataset of 2,413 tumors. BLM protein level was evaluated in the Nottingham Tenovus series comprising 1,650 breast tumors. BLM mRNA overexpression was significantly associated with high histologic grade, larger tumor size, estrogen receptor-negative (ER(-)), progesterone receptor-negative (PR(-)), and triple-negative phenotypes (ps < 0.0001). BLM mRNA overexpression was also linked to aggressive molecular phenotypes, including PAM50.Her2 (P < 0.0001), PAM50.Basal (P < 0.0001), and PAM50.LumB (P < 0.0001) and Genufu subtype (ER(+)/Her2(-)/high proliferation; P < 0.0001). PAM50.LumA tumors and Genufu subtype (ER(+)/Her2(-)/low proliferation) were more likely to express low levels of BLM mRNA (ps < 0.0001). Integrative molecular clusters (intClust) intClust.1 (P < 0.0001), intClust.5 (P < 0.0001), intClust.9 (P < 0.0001), and intClust.10 (P < 0.0001) were also more likely in tumors with high BLM mRNA expression. BLM mRNA overexpression was associated with poor breast cancer-specific survival (BCSS; ps < 0.000001). At the protein level, altered subcellular localization with high cytoplasmic BLM and low nuclear BLM was linked to aggressive phenotypes. In multivariate analysis, BLM mRNA and BLM protein levels independently influenced BCSS. This is the first and the largest study to provide evidence that BLM is a promising biomarker in breast cancer. PMID:25673821

  20. USGS and BLM agree to expand mapping coordination

    NASA Astrophysics Data System (ADS)

    The U.S. Geological Survey, the largest civilian mapping agency, has just joined hands with the Bureau of Land Management (BLM), the largest federal land management agency, in an agreement to expand coordination of their mapping efforts and develop cartographic technology of mutual benefit.The Memorandum of Understanding signed by the agencies provides a mechanism to produce and exchange conventional maps, digital cartographic data, and remotely sensed data. The new agreement will also help enforce national standards in map making, which will make the data more available and useful to a wider audience.

  1. 43 CFR 3206.11 - What must BLM do before issuing a lease?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false What must BLM do before issuing a lease? 3206.11 Section 3206.11 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) GEOTHERMAL RESOURCE LEASING Lease Issuance § 3206.11 What must BLM...

  2. 43 CFR 3503.38 - How does BLM compute my acreage holdings?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false How does BLM compute my acreage holdings? 3503.38 Section 3503.38 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU... OTHER THAN COAL AND OIL SHALE Areas Available for Leasing Acreage Amounts § 3503.38 How does BLM...

  3. 43 CFR 3503.38 - How does BLM compute my acreage holdings?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false How does BLM compute my acreage holdings? 3503.38 Section 3503.38 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU... OTHER THAN COAL AND OIL SHALE Areas Available for Leasing Acreage Amounts § 3503.38 How does BLM...

  4. 43 CFR 3503.38 - How does BLM compute my acreage holdings?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false How does BLM compute my acreage holdings? 3503.38 Section 3503.38 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU... OTHER THAN COAL AND OIL SHALE Areas Available for Leasing Acreage Amounts § 3503.38 How does BLM...

  5. 43 CFR 3503.38 - How does BLM compute my acreage holdings?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false How does BLM compute my acreage holdings? 3503.38 Section 3503.38 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU... OTHER THAN COAL AND OIL SHALE Areas Available for Leasing Acreage Amounts § 3503.38 How does BLM...

  6. 43 CFR 3270.12 - What other orders or instructions may BLM issue?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) GEOTHERMAL RESOURCE LEASING Utilization of Geothermal Resources-General § 3270.12 What other orders or instructions may BLM issue? BLM may issue: (a) Geothermal resource operational orders, for detailed requirements that...

  7. 43 CFR 3260.12 - What other orders or instructions may BLM issue?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) GEOTHERMAL RESOURCE LEASING Geothermal Drilling Operations-General § 3260.12 What other orders or instructions may BLM issue? BLM may issue: (a) Geothermal resource operational orders for detailed requirements that...

  8. 43 CFR 2932.21 - Why should I contact BLM before submitting an application?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Why should I contact BLM before submitting an application? 2932.21 Section 2932.21 Public Lands: Interior Regulations Relating to Public Lands... Groups, and Recreation Use in Special Areas § 2932.21 Why should I contact BLM before submitting...

  9. 43 CFR 3137.51 - Under what conditions does BLM permit multiple unit operators?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Under what conditions does BLM permit multiple unit operators? 3137.51 Section 3137.51 Public Lands: Interior Regulations Relating to Public...-Alaska Optional Terms § 3137.51 Under what conditions does BLM permit multiple unit operators?...

  10. 43 CFR 3601.51 - How will BLM inspect my operation?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false How will BLM inspect my operation? 3601.51 Section 3601.51 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND... Materials Disposal; General Provisions Contract and Permit Administration § 3601.51 How will BLM inspect...

  11. 43 CFR 3508.22 - What happens if BLM rejects my bid?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false What happens if BLM rejects my bid? 3508... THAN COAL AND OIL SHALE Competitive Lease Applications § 3508.22 What happens if BLM rejects my bid? (a) If your bid is the high bid and we reject it because you did not sign the lease form and pay...

  12. 43 CFR 3602.49 - When will BLM issue a non-renewable contract?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false When will BLM issue a non-renewable contract? 3602.49 Section 3602.49 Public Lands: Interior Regulations Relating to Public Lands (Continued... DISPOSAL Mineral Materials Sales Competitive Sales § 3602.49 When will BLM issue a non-renewable...

  13. 43 CFR 3602.49 - When will BLM issue a non-renewable contract?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false When will BLM issue a non-renewable contract? 3602.49 Section 3602.49 Public Lands: Interior Regulations Relating to Public Lands (Continued... DISPOSAL Mineral Materials Sales Competitive Sales § 3602.49 When will BLM issue a non-renewable...

  14. 43 CFR 3602.49 - When will BLM issue a non-renewable contract?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false When will BLM issue a non-renewable contract? 3602.49 Section 3602.49 Public Lands: Interior Regulations Relating to Public Lands (Continued... DISPOSAL Mineral Materials Sales Competitive Sales § 3602.49 When will BLM issue a non-renewable...

  15. 43 CFR 3602.49 - When will BLM issue a non-renewable contract?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false When will BLM issue a non-renewable contract? 3602.49 Section 3602.49 Public Lands: Interior Regulations Relating to Public Lands (Continued... DISPOSAL Mineral Materials Sales Competitive Sales § 3602.49 When will BLM issue a non-renewable...

  16. 43 CFR 3263.14 - May BLM require me to abandon a well?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false May BLM require me to abandon a well? 3263.14 Section 3263.14 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) GEOTHERMAL RESOURCE LEASING Well Abandonment § 3263.14 May BLM require me...

  17. 43 CFR 3602.43 - How does BLM conduct competitive mineral materials sales?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false How does BLM conduct competitive mineral... (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL MATERIALS DISPOSAL Mineral Materials Sales Competitive Sales § 3602.43 How does BLM conduct...

  18. 43 CFR 3602.43 - How does BLM conduct competitive mineral materials sales?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false How does BLM conduct competitive mineral... (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL MATERIALS DISPOSAL Mineral Materials Sales Competitive Sales § 3602.43 How does BLM conduct...

  19. 43 CFR 3602.43 - How does BLM conduct competitive mineral materials sales?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false How does BLM conduct competitive mineral... (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL MATERIALS DISPOSAL Mineral Materials Sales Competitive Sales § 3602.43 How does BLM conduct...

  20. 43 CFR 3602.42 - How does BLM publicize competitive mineral materials sales?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false How does BLM publicize competitive mineral... (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL MATERIALS DISPOSAL Mineral Materials Sales Competitive Sales § 3602.42 How does BLM publicize...

  1. 43 CFR 3602.42 - How does BLM publicize competitive mineral materials sales?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false How does BLM publicize competitive mineral... (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL MATERIALS DISPOSAL Mineral Materials Sales Competitive Sales § 3602.42 How does BLM publicize...

  2. 43 CFR 3602.43 - How does BLM conduct competitive mineral materials sales?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false How does BLM conduct competitive mineral... (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL MATERIALS DISPOSAL Mineral Materials Sales Competitive Sales § 3602.43 How does BLM conduct...

  3. 43 CFR 3602.42 - How does BLM publicize competitive mineral materials sales?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false How does BLM publicize competitive mineral... (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL MATERIALS DISPOSAL Mineral Materials Sales Competitive Sales § 3602.42 How does BLM publicize...

  4. 43 CFR 3602.41 - When will BLM sell mineral materials on a competitive basis?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false When will BLM sell mineral materials on a... (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL MATERIALS DISPOSAL Mineral Materials Sales Competitive Sales § 3602.41 When will BLM sell mineral...

  5. 43 CFR 3602.41 - When will BLM sell mineral materials on a competitive basis?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false When will BLM sell mineral materials on a... (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL MATERIALS DISPOSAL Mineral Materials Sales Competitive Sales § 3602.41 When will BLM sell mineral...

  6. 43 CFR 3602.41 - When will BLM sell mineral materials on a competitive basis?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false When will BLM sell mineral materials on a... (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL MATERIALS DISPOSAL Mineral Materials Sales Competitive Sales § 3602.41 When will BLM sell mineral...

  7. 43 CFR 3602.42 - How does BLM publicize competitive mineral materials sales?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false How does BLM publicize competitive mineral... (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL MATERIALS DISPOSAL Mineral Materials Sales Competitive Sales § 3602.42 How does BLM publicize...

  8. Stream and River Condition Across the BLM's National System of Public Lands.

    EPA Science Inventory

    The Bureau of Land Management (BLM), in collaboration with the U.S. Environmental Protection Agency, conducted the first ever Western Rivers and Streams Assessment (WRSA), a survey of the condition of BLM streams and rivers throughout the contiguous western U.S. The WRSA was desi...

  9. Stream and River Condition Across the BLM's National System of Public Lands

    EPA Science Inventory

    Meeting Abstract: The Bureau of Land Management (BLM), in collaboration with the U.S. Environmental Protection Agency, conducted the first ever Western Rivers and Streams Assessment (WRSA), a survey of the condition of BLM streams and rivers throughout the contiguous western U.S...

  10. 43 CFR 3601.14 - When can BLM dispose of mineral materials from unpatented mining claims?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) MINERAL MATERIALS DISPOSAL Mineral Materials Disposal; General Provisions Limitations on Disposal of...) BLM may dispose of mineral materials from unpatented mining claims if disposal does not endanger or.... If the mining claimant refuses to sign a waiver, BLM will make sure that disposal of the...

  11. 43 CFR 3601.14 - When can BLM dispose of mineral materials from unpatented mining claims?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) MINERAL MATERIALS DISPOSAL Mineral Materials Disposal; General Provisions Limitations on Disposal of...) BLM may dispose of mineral materials from unpatented mining claims if disposal does not endanger or.... If the mining claimant refuses to sign a waiver, BLM will make sure that disposal of the...

  12. 43 CFR 3601.14 - When can BLM dispose of mineral materials from unpatented mining claims?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) MINERAL MATERIALS DISPOSAL Mineral Materials Disposal; General Provisions Limitations on Disposal of...) BLM may dispose of mineral materials from unpatented mining claims if disposal does not endanger or.... If the mining claimant refuses to sign a waiver, BLM will make sure that disposal of the...

  13. 43 CFR 3601.14 - When can BLM dispose of mineral materials from unpatented mining claims?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) MINERAL MATERIALS DISPOSAL Mineral Materials Disposal; General Provisions Limitations on Disposal of...) BLM may dispose of mineral materials from unpatented mining claims if disposal does not endanger or.... If the mining claimant refuses to sign a waiver, BLM will make sure that disposal of the...

  14. 78 FR 60309 - Notice of Public Meeting, BLM-Alaska Resource Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-01

    ... Bureau of Land Management Notice of Public Meeting, BLM-Alaska Resource Advisory Council AGENCY: Bureau of Land Management, Alaska State Office, Interior. ACTION: Notice of public meeting. SUMMARY: In... 1972 (FACA), the U.S. Department of the Interior, Bureau of Land Management (BLM) Alaska...

  15. 25 CFR 212.4 - Authority and responsibility of the Bureau of Land Management (BLM).

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... the Bureau of Land Management (BLM). The functions of the Bureau of Land Management are found in 43... 25 Indians 1 2013-04-01 2013-04-01 false Authority and responsibility of the Bureau of Land Management (BLM). 212.4 Section 212.4 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY...

  16. 43 CFR 3275.20 - What will BLM do if I waste geothermal resources?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false What will BLM do if I waste geothermal... LEASING Conducting Utilization Operations § 3275.20 What will BLM do if I waste geothermal resources? We will determine the amount of any resources you have lost through waste. If you did not take...

  17. 43 CFR 3275.20 - What will BLM do if I waste geothermal resources?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false What will BLM do if I waste geothermal... LEASING Conducting Utilization Operations § 3275.20 What will BLM do if I waste geothermal resources? We will determine the amount of any resources you have lost through waste. If you did not take...

  18. 43 CFR 3275.20 - What will BLM do if I waste geothermal resources?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false What will BLM do if I waste geothermal... LEASING Conducting Utilization Operations § 3275.20 What will BLM do if I waste geothermal resources? We will determine the amount of any resources you have lost through waste. If you did not take...

  19. 43 CFR 3275.20 - What will BLM do if I waste geothermal resources?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false What will BLM do if I waste geothermal... LEASING Conducting Utilization Operations § 3275.20 What will BLM do if I waste geothermal resources? We will determine the amount of any resources you have lost through waste. If you did not take...

  20. Structure of a Blm10 complex reveals common mechanisms for proteasome binding and gate opening

    PubMed Central

    Sadre-Bazzaz, Kianoush; Whitby, Frank G.; Robinson, Howard; Formosa, Tim; Hill, Christopher P.

    2010-01-01

    Summary The proteasome is an abundant protease that is critically important for numerous cellular pathways. Proteasomes are activated in vitro by three known classes of proteins/complexes, including Blm10/PA200. Here we report a 3.4Å resolution crystal structure of a proteasome-Blm10 complex, which reveals that Blm10 surrounds the proteasome entry pore in the 1.2 MDa complex to form a largely closed dome that is expected to restrict access of potential substrates. This architecture, and the observation that Blm10 induces a disordered proteasome gate structure, challenges the assumption that Blm10 functions as an activator of proteolysis in vivo. The Blm10 C-terminus binds in the same manner as seen for 11S activators and inferred for 19S/PAN activators, and indicates a unified model for gate opening. We also demonstrate that Blm10 acts to maintain mitochondrial function. Consistent with the structural data, the C-terminal residues of Blm10 are needed for this activity. PMID:20227375

  1. 43 CFR 6302.14 - What authorization do I need to climb in BLM wilderness?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... BLM wilderness? 6302.14 Section 6302.14 Public Lands: Interior Regulations Relating to Public Lands...) MANAGEMENT OF DESIGNATED WILDERNESS AREAS Use of Wilderness Areas, Prohibited Acts, and Penalties Use of Wilderness Areas § 6302.14 What authorization do I need to climb in BLM wilderness? (a) You do not need...

  2. 43 CFR 6302.14 - What authorization do I need to climb in BLM wilderness?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... BLM wilderness? 6302.14 Section 6302.14 Public Lands: Interior Regulations Relating to Public Lands...) MANAGEMENT OF DESIGNATED WILDERNESS AREAS Use of Wilderness Areas, Prohibited Acts, and Penalties Use of Wilderness Areas § 6302.14 What authorization do I need to climb in BLM wilderness? (a) You do not need...

  3. 43 CFR 6302.14 - What authorization do I need to climb in BLM wilderness?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... BLM wilderness? 6302.14 Section 6302.14 Public Lands: Interior Regulations Relating to Public Lands...) MANAGEMENT OF DESIGNATED WILDERNESS AREAS Use of Wilderness Areas, Prohibited Acts, and Penalties Use of Wilderness Areas § 6302.14 What authorization do I need to climb in BLM wilderness? (a) You do not need...

  4. 43 CFR 6302.14 - What authorization do I need to climb in BLM wilderness?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... BLM wilderness? 6302.14 Section 6302.14 Public Lands: Interior Regulations Relating to Public Lands...) MANAGEMENT OF DESIGNATED WILDERNESS AREAS Use of Wilderness Areas, Prohibited Acts, and Penalties Use of Wilderness Areas § 6302.14 What authorization do I need to climb in BLM wilderness? (a) You do not need...

  5. 43 CFR 3602.14 - What kind of financial security does BLM require?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL MATERIALS...? (a) For contracts of $2,000 or more, BLM will require a performance bond of an amount sufficient to... post a performance bond. (b) BLM may require a performance bond for contracts of less than $2,000....

  6. 43 CFR 3213.15 - How will BLM notify me if it terminates my lease?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false How will BLM notify me if it terminates my lease? 3213.15 Section 3213.15 Public Lands: Interior Regulations Relating to Public Lands (Continued... LEASING Relinquishment, Termination, and Cancellation § 3213.15 How will BLM notify me if it terminates...

  7. 43 CFR 3215.11 - Must I replace my bond after BLM collects against it?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Must I replace my bond after BLM collects against it? 3215.11 Section 3215.11 Public Lands: Interior Regulations Relating to Public Lands (Continued... against it? If BLM collects against your bond, before you conduct any further operations you must...

  8. 43 CFR 3213.15 - How will BLM notify me if it terminates my lease?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false How will BLM notify me if it terminates my lease? 3213.15 Section 3213.15 Public Lands: Interior Regulations Relating to Public Lands (Continued... LEASING Relinquishment, Termination, and Cancellation § 3213.15 How will BLM notify me if it terminates...

  9. 43 CFR 3213.15 - How will BLM notify me if it terminates my lease?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false How will BLM notify me if it terminates my lease? 3213.15 Section 3213.15 Public Lands: Interior Regulations Relating to Public Lands (Continued... LEASING Relinquishment, Termination, and Cancellation § 3213.15 How will BLM notify me if it terminates...

  10. 43 CFR 3215.11 - Must I replace my bond after BLM collects against it?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Must I replace my bond after BLM collects against it? 3215.11 Section 3215.11 Public Lands: Interior Regulations Relating to Public Lands (Continued... against it? If BLM collects against your bond, before you conduct any further operations you must...

  11. 43 CFR 3215.11 - Must I replace my bond after BLM collects against it?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Must I replace my bond after BLM collects against it? 3215.11 Section 3215.11 Public Lands: Interior Regulations Relating to Public Lands (Continued... against it? If BLM collects against your bond, before you conduct any further operations you must...

  12. 43 CFR 3215.11 - Must I replace my bond after BLM collects against it?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Must I replace my bond after BLM collects against it? 3215.11 Section 3215.11 Public Lands: Interior Regulations Relating to Public Lands (Continued... against it? If BLM collects against your bond, before you conduct any further operations you must...

  13. 43 CFR 3213.15 - How will BLM notify me if it terminates my lease?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false How will BLM notify me if it terminates my lease? 3213.15 Section 3213.15 Public Lands: Interior Regulations Relating to Public Lands (Continued... LEASING Relinquishment, Termination, and Cancellation § 3213.15 How will BLM notify me if it terminates...

  14. 43 CFR 3715.3-3 - How does BLM process the information I submit about my proposed occupancy?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false How does BLM process the information I... (3000) PUBLIC LAW 167; ACT OF JULY 23, 1955 Use and Occupancy Under the Mining Laws § 3715.3-3 How does BLM process the information I submit about my proposed occupancy? BLM will review all...

  15. 43 CFR 3715.3-3 - How does BLM process the information I submit about my proposed occupancy?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false How does BLM process the information I... (3000) PUBLIC LAW 167; ACT OF JULY 23, 1955 Use and Occupancy Under the Mining Laws § 3715.3-3 How does BLM process the information I submit about my proposed occupancy? BLM will review all...

  16. 43 CFR 3715.3-3 - How does BLM process the information I submit about my proposed occupancy?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false How does BLM process the information I... (3000) PUBLIC LAW 167; ACT OF JULY 23, 1955 Use and Occupancy Under the Mining Laws § 3715.3-3 How does BLM process the information I submit about my proposed occupancy? BLM will review all...

  17. 43 CFR 5040.2 - What will BLM do before it establishes sustained-yield forest units?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false What will BLM do before it establishes...) SUSTAINED-YIELD FOREST UNITS § 5040.2 What will BLM do before it establishes sustained-yield forest units? Before BLM designates sustained-yield forest units, it will: (a) Hold a public hearing in the area...

  18. 43 CFR 3809.411 - What action will BLM take when it receives my plan of operations?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false What action will BLM take when it receives... Operations § 3809.411 What action will BLM take when it receives my plan of operations? (a) BLM will review... is complete, that is, it meets the content requirements of § 3809.401(b); (2) Your plan does...

  19. 43 CFR 5040.2 - What will BLM do before it establishes sustained-yield forest units?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false What will BLM do before it establishes...) SUSTAINED-YIELD FOREST UNITS § 5040.2 What will BLM do before it establishes sustained-yield forest units? Before BLM designates sustained-yield forest units, it will: (a) Hold a public hearing in the area...

  20. 43 CFR 3809.411 - What action will BLM take when it receives my plan of operations?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false What action will BLM take when it receives... Operations § 3809.411 What action will BLM take when it receives my plan of operations? (a) BLM will review... is complete, that is, it meets the content requirements of § 3809.401(b); (2) Your plan does...

  1. Measuring Divergent Abilities.

    ERIC Educational Resources Information Center

    Sefer, Jasmina

    The validity and reliability of the Yugoslavian (Beograd) version of the Hungarian adaptation of the Torrance Divergent Capacities Test (HAT-DAT) were tested, with a view toward improving the methodology of scoring the creative abilities test and determining standards for Yugoslavia. The test, based on the work of J. P. Guilford (1977), examines…

  2. Converging or Diverging Lens?

    ERIC Educational Resources Information Center

    Branca, Mario

    2013-01-01

    Why does a lens magnify? Why does it shrink objects? Why does this happen? The activities that we propose here are useful in helping us to understand how lenses work, and they show that the same lens can have different magnification capabilities. A converging lens can also act as a diverging lens. (Contains 4 figures.)

  3. Divergent RNA transcription

    PubMed Central

    Naughton, Catherine; Corless, Samuel; Gilbert, Nick

    2013-01-01

    New approaches using biotinylated-psoralen as a probe for investigating DNA structure have revealed new insights into the relationship between DNA supercoiling, transcription and chromatin compaction. We explore a hypothesis that divergent RNA transcription generates negative supercoiling at promoters facilitating initiation complex formation and subsequent promoter clearance. PMID:23863199

  4. Parallels and Divergences?

    ERIC Educational Resources Information Center

    Spray, Martin

    1985-01-01

    Discusses the varying philosophical viewpoints and program orientations associated with the conservation movement, assessing the implications of these divergences on the objectives and instructional methods of environmental education. Also identifies and explains the range of differences existing in environmental education programs. (ML)

  5. Ion divergence in magnetically insulated diodes

    SciTech Connect

    Slutz, S.A.; Lemke, R.W.; Pointon, T.D.; Desjarlais, M.P.; Johnson, D.J.; Mehlhorn, T.A.; Filuk, A.; Bailey, J.

    1995-12-01

    Magnetically insulated ion diodes are being developed to drive inertial confinement fusion. Ion beam microdivergence must be reduced to achieve the very high beam intensities required to achieve this goal. Three-dimensional particle-in-cell simulations indicate that instability induced fluctuations can produce significant ion divergence during acceleration. These simulations exhibit a fast growing mode early in time, which has been identified as the diocotron instability. The divergence generated by this mode is modest due to the relatively high frequency (>1GHz). Later, a low-frequency low-phase-velocity instability develops. This instability couples effectively to the ions, since the frequency is approximately the reciprocal of the ion transit time, and can generate unacceptably large ion divergences (>30 mrad). Linear stability theory reveals that this mode requires perturbations parallel to the applied magnetic field and is related to the modified two stream instability. Measurements of ion density fluctuations and energy-momentum correlations have confirmed that instabilities develop in ion diodes and contribute to the ion divergence. In addition, spectroscopic measurements indicate that the ions have a significant transverse temperature very close to the emission surface. Passive lithium fluoride (LiF) anodes have larger transverse beam temperatures than laser irradiated active sources. Calculations of source divergence expected from the roughness of LiF surfaces and the possible removal of this layer is presented.

  6. PICH and BLM limit histone association with anaphase centromeric DNA threads and promote their resolution

    PubMed Central

    Ke, Yuwen; Huh, Jae-Wan; Warrington, Ross; Li, Bing; Wu, Nan; Leng, Mei; Zhang, Junmei; Ball, Haydn L; Li, Bing; Yu, Hongtao

    2011-01-01

    Centromeres nucleate the formation of kinetochores and are vital for chromosome segregation during mitosis. The SNF2 family helicase PICH (Plk1-interacting checkpoint helicase) and the BLM (the Bloom's syndrome protein) helicase decorate ultrafine histone-negative DNA threads that link the segregating sister centromeres during anaphase. The functions of PICH and BLM at these threads are not understood, however. Here, we show that PICH binds to BLM and enables BLM localization to anaphase centromeric threads. PICH- or BLM-RNAi cells fail to resolve these threads in anaphase. The fragmented threads form centromeric-chromatin-containing micronuclei in daughter cells. Anaphase threads in PICH- and BLM-RNAi cells contain histones and centromere markers. Recombinant purified PICH has nucleosome remodelling activities in vitro. We propose that PICH and BLM unravel centromeric chromatin and keep anaphase DNA threads mostly free of nucleosomes, thus allowing these threads to span long distances between rapidly segregating centromeres without breakage and providing a spatiotemporal window for their resolution. PMID:21743438

  7. PICH and BLM limit histone association with anaphase centromeric DNA threads and promote their resolution.

    PubMed

    Ke, Yuwen; Huh, Jae-Wan; Warrington, Ross; Li, Bing; Wu, Nan; Leng, Mei; Zhang, Junmei; Ball, Haydn L; Li, Bing; Yu, Hongtao

    2011-08-17

    Centromeres nucleate the formation of kinetochores and are vital for chromosome segregation during mitosis. The SNF2 family helicase PICH (Plk1-interacting checkpoint helicase) and the BLM (the Bloom's syndrome protein) helicase decorate ultrafine histone-negative DNA threads that link the segregating sister centromeres during anaphase. The functions of PICH and BLM at these threads are not understood, however. Here, we show that PICH binds to BLM and enables BLM localization to anaphase centromeric threads. PICH- or BLM-RNAi cells fail to resolve these threads in anaphase. The fragmented threads form centromeric-chromatin-containing micronuclei in daughter cells. Anaphase threads in PICH- and BLM-RNAi cells contain histones and centromere markers. Recombinant purified PICH has nucleosome remodelling activities in vitro. We propose that PICH and BLM unravel centromeric chromatin and keep anaphase DNA threads mostly free of nucleosomes, thus allowing these threads to span long distances between rapidly segregating centromeres without breakage and providing a spatiotemporal window for their resolution. PMID:21743438

  8. Sgs1 Truncations Induce Genome Rearrangements but Suppress Detrimental Effects of BLM Overexpression in Saccharomyces cerevisiae

    PubMed Central

    Mirzaei, Hamed; Syed, Salahuddin; Kennedy, Jessica; Schmidt, Kristina H

    2011-01-01

    RecQ-like DNA helicases are conserved from bacteria to humans. They perform functions in the maintenance of genome stability, and their mutation is associated with cancer predisposition and premature aging syndromes in humans. Here, a series of C-terminal deletions and point mutations of Sgs1, the only RecQ-like helicase in yeast, show that the HRDC and Rad51 interaction domain are dispensable for Sgs1’s role in suppressing genome instability, whereas the zinc-binding domain and the helicase domain are required. BLM expression from the native SGS1 promoter had no adverse effects on cell growth, but also was unable to complement any sgs1Δ defects. BLM overexpression, however, significantly increased the rate of accumulating GCRs in a dosage-dependent manner and greatly exacerbated sensitivity to DNA-damaging agents. Co-expressing sgs1 truncations of up to 900 residues, lacking all known functional domains of Sgs1, suppressed HU sensitivity of BLM overexpressing cells, suggesting a functional relationship between Sgs1 and BLM. Indeed, protein disorder prediction analysis of Sgs1 and BLM was used to produce a functional Sgs1-BLM chimera by replacing the N-terminus of BLM with the disordered N-terminus of Sgs1. The functionality of this chimera suggests that it is the disordered N-terminus, a site of protein binding and post-translational modification, that confers species-specificity to these two RecQ-like proteins. PMID:21111748

  9. Divergence Boundary Conditions for Vector Helmholtz Equations with Divergence Constraints

    NASA Technical Reports Server (NTRS)

    Kangro, Urve; Nicolaides, Roy

    1997-01-01

    The idea of replacing a divergence constraint by a divergence boundary condition is investigated. The connections between the formulations are considered in detail. It is shown that the most common methods of using divergence boundary conditions do not always work properly. Necessary and sufficient conditions for the equivalence of the formulations are given.

  10. Celastrol enhances Nrf2 mediated antioxidant enzymes and exhibits anti-fibrotic effect through regulation of collagen production against bleomycin-induced pulmonary fibrosis.

    PubMed

    Divya, Thomas; Dineshbabu, Vadivel; Soumyakrishnan, Syamala; Sureshkumar, Anandasadagopan; Sudhandiran, Ganapasam

    2016-02-25

    Pulmonary fibrosis (PF) is characterized by excessive accumulation of extracellular matrix components in the alveolar region which distorts the normal lung architecture and impairs the respiratory function. The aim of this study is to evaluate the anti-fibrotic effect of celastrol, a quinine-methide tri-terpenoid mainly found in Thunder God Vine root extracts against bleomycin (BLM)-induced PF through the enhancement of antioxidant defense system. A single intratracheal instillation of BLM (3 U/kg.bw) was administered in rats to induce PF. Celastrol (5 mg/kg) was given intraperitoneally, twice a week for a period of 28 days. BLM-induced rats exhibits declined activities of enzymatic and non-enzymatic antioxidants which were restored upon treatment with celastrol. BLM-induced rats show increased total and differential cell counts as compared to control and celastrol treated rats. Histopathological analysis shows increased inflammation and alveolar damage; while assay of hydroxyproline and Masson's trichrome staining shows an increased collagen deposition in BLM-challenged rats that were decreased upon celastrol treatment. Celastrol also reduces inflammation in BLM-induced rats as evidenced by decrease in the expressions of mast cells, Tumor necrosis factor-alpha (TNF- α) and matrix metalloproteinases (MMPs) 2 and 9. Further, Western blot analysis shows that celastrol is a potent inducer of NF-E2-related factor 2 (Nrf2) and it restores the activities of Phase II enzymes such as hemoxygenase-1 (HO-1), glutathione-S-transferase (GSTs) and NADP(H): quinine oxidoreductase (NQO1) which were declined upon BLM administration. The results of this study show evidence on the protective effect of celastrol against BLM-induced PF through its antioxidant and anti-fibrotic effects. PMID:26768587

  11. 43 CFR 3280.3 - What is BLM's general policy regarding the formation of unit agreements?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) GEOTHERMAL RESOURCES UNIT AGREEMENTS Geothermal Resources Unit Agreements-General § 3280.3 What is BLM's... natural resources of any geothermal reservoir, field, or like area, or any part thereof, lessees and...

  12. 43 CFR 3602.13 - How does BLM measure and establish the price of mineral materials?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000... contract renewal period. (c) BLM measures mineral materials by in-place volume or weight equivalent....

  13. 43 CFR 3809.5 - How does BLM define certain terms used in this subpart?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Land Policy and Management Act of 1976 (43 U.S.C. 1701 et seq.). Mitigation, as defined in 40 CFR 1508... terms of temporary closures ordered by BLM. (2) Casual use does not include use of mechanized...

  14. 43 CFR 3809.5 - How does BLM define certain terms used in this subpart?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Land Policy and Management Act of 1976 (43 U.S.C. 1701 et seq.). Mitigation, as defined in 40 CFR 1508... terms of temporary closures ordered by BLM. (2) Casual use does not include use of mechanized...

  15. 43 CFR 4300.53 - Can BLM reduce the size of the land in my permit?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...; ALASKA; REINDEER; GENERAL Changes in the Size of the Permit Area § 4300.53 Can BLM reduce the size of the... number of reindeer you are grazing; or (b) When disposal, withdrawal, natural causes, such as drought...

  16. 43 CFR 4300.53 - Can BLM reduce the size of the land in my permit?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...; ALASKA; REINDEER; GENERAL Changes in the Size of the Permit Area § 4300.53 Can BLM reduce the size of the... number of reindeer you are grazing; or (b) When disposal, withdrawal, natural causes, such as drought...

  17. 43 CFR 4300.53 - Can BLM reduce the size of the land in my permit?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...; ALASKA; REINDEER; GENERAL Changes in the Size of the Permit Area § 4300.53 Can BLM reduce the size of the... number of reindeer you are grazing; or (b) When disposal, withdrawal, natural causes, such as drought...

  18. 43 CFR 4300.53 - Can BLM reduce the size of the land in my permit?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...; ALASKA; REINDEER; GENERAL Changes in the Size of the Permit Area § 4300.53 Can BLM reduce the size of the... number of reindeer you are grazing; or (b) When disposal, withdrawal, natural causes, such as drought...

  19. Higher-order prediction terms and fixing the renormalization scale using the BLM approach

    NASA Astrophysics Data System (ADS)

    Mirjalili, Abolfazl; Khellat, Mohammad Reza

    2014-12-01

    There is an ambiguity in the perturbative series of QCD observables on how to choose the renormalization and even more the factorization scale. There are many approaches to overcome this obstacle and to fix the scales. Among them, there is the Brodsky-Lepage-Mackenzie (BLM) approach which is based on an intriguing principle. Based on the BLM approach, we intend to absorb the nf-terms in the pQCD series that rightly determines the running behavior of the running coupling into the running coupling. We make an extensive use of the BLM approach to investigate the details of predicting higher order correction terms of some QCD observables. By this way we test different methods to improve the prediction process. It is also found out that an overall normalization could change BLM predictions effectively.

  20. 43 CFR 3507.19 - Under what circumstances will BLM reject my application?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... requirements of this subpart; or (4) In the case of sodium, potassium and sulphur, if BLM determines that the... the application. In making this determination, we will consider: (1) The land use plan;...

  1. Sources and Structures of Mitotic Crossovers That Arise When BLM Helicase Is Absent in Drosophila

    PubMed Central

    LaFave, Matthew C.; Andersen, Sabrina L.; Stoffregen, Eric P.; Holsclaw, Julie K.; Kohl, Kathryn P.; Overton, Lewis J.; Sekelsky, Jeff

    2014-01-01

    The Bloom syndrome helicase, BLM, has numerous functions that prevent mitotic crossovers. We used unique features of Drosophila melanogaster to investigate origins and properties of mitotic crossovers that occur when BLM is absent. Induction of lesions that block replication forks increased crossover frequencies, consistent with functions for BLM in responding to fork blockage. In contrast, treatment with hydroxyurea, which stalls forks, did not elevate crossovers, even though mutants lacking BLM are sensitive to killing by this agent. To learn about sources of spontaneous recombination, we mapped mitotic crossovers in mutants lacking BLM. In the male germline, irradiation-induced crossovers were distributed randomly across the euchromatin, but spontaneous crossovers were nonrandom. We suggest that regions of the genome with a high frequency of mitotic crossovers may be analogous to common fragile sites in the human genome. Interestingly, in the male germline there is a paucity of crossovers in the interval that spans the pericentric heterochromatin, but in the female germline this interval is more prone to crossing over. Finally, our system allowed us to recover pairs of reciprocal crossover chromosomes. Sequencing of these revealed the existence of gene conversion tracts and did not provide any evidence for mutations associated with crossovers. These findings provide important new insights into sources and structures of mitotic crossovers and functions of BLM helicase. PMID:24172129

  2. Loss of Blm enhances basal cell carcinoma and rhabdomyosarcoma tumorigenesis in Ptch1+/- mice.

    PubMed

    Davari, Parastoo; Hebert, Jennifer L; Albertson, Donna G; Huey, Bing; Roy, Ritu; Mancianti, Maria L; Horvai, Andrew E; McDaniel, Lisa D; Schultz, Roger A; Epstein, Ervin H

    2010-06-01

    Basal cell carcinomas (BCCs) have relative genomic stability and relatively benign clinical behavior but whether these two are related causally is unknown. To investigate the effects of introducing genomic instability into murine BCCs, we have compared ionizing radiation-induced tumorigenesis in Ptch1(+/-) mice versus that in Ptch1(+/-) mice carrying mutant Blm alleles. We found that BCCs in Ptch1(+/-) Blm(tm3Brd/tm3Brd) mice had a trend toward greater genomic instability as measured by array comprehensive genomic hybridization and that these mice developed significantly more microscopic BCCs than did Ptch1(+/-) Blm(+/tm3Brd) or Ptch1(+/-) Blm(+/+) mice. The mutant Blm alleles also markedly enhanced the formation of rhabdomyosarcomas (RMSs), another cancer to which Ptch1(+/)(-) mice and PTCH1(+/)(-) (basal cell nevus syndrome) patients are susceptible. Highly recurrent but different copy number changes were associated with the two tumor types and included losses of chromosomes 4 and 10 in all BCCs and gain of chromosome 10 in 80% of RMSs. Loss of chromosome 11 and 13, including the Trp53 and Ptch1 loci, respectively, occurred frequently in BCCs, suggesting tissue-specific selection for genes or pathways that collaborate with Ptch deficiency in tumorigenesis. Despite the quantitative differences, there was no dramatic qualititative difference in the BCC or RMS tumors associated with the mutant Blm genotype. PMID:19995795

  3. Dynamic Investigation of Static Divergence: Analysis and Testing

    NASA Technical Reports Server (NTRS)

    Heeg, Jennifer

    2000-01-01

    The phenomenon known as aeroelastic divergence is the focus of this work. The analyses and experiment presented here show that divergence can occur without a structural dynamic mode losing its oscillatory nature. Aeroelastic divergence occurs when the structural restorative capability or stiffness of a structure is overwhelmed by the static aerodynamic moment. This static aeroelastic coupling does not require the structural dynamic system behavior to cease, however. Aeroelastic changes in the dynamic mode behavior are governed not only by the stiffness, but by damping and inertial properties. The work presented here supports these fundamental assertions by examining a simple system: a typical section airfoil with only a rotational structural degree of freedom. Analytical results identified configurations that exhibit different types of dynamic mode behavior as the system encounters divergence. A wind tunnel model was designed and tested to examine divergence experimentally. The experimental results validate the analytical calculations and explicitly examine the divergence phenomenon where the dynamic mode persists. Three configurations of the wind tunnel model were tested. The experimental results agree very well with the analytical predictions of subcritical characteristics, divergence velocity, and behavior of the noncritical dynamic mode at divergence.

  4. Ethics on Exhibit

    ERIC Educational Resources Information Center

    Vick, Randy M.

    2011-01-01

    This article discusses ethical questions raised by an exhibition of work by an artist with a history of mental illness and the exhibition's relevance to art therapy and “outsider art” discourse on the subject. Considerations for how such an exhibit could be handled had the circumstances included an art therapist and art therapy client are…

  5. An Exhibit for Touching.

    ERIC Educational Resources Information Center

    Hunt, Susan

    1979-01-01

    An exhibit designed for visually handicapped persons presented by the Kalamazoo (Michigan) Institute of Art included bronze sculptures and oil paintings from the institute's permanent collection. (CL)

  6. Divergence in Dialogue

    PubMed Central

    Healey, Patrick G. T.; Purver, Matthew; Howes, Christine

    2014-01-01

    One of the best known claims about human communication is that people's behaviour and language use converge during conversation. It has been proposed that these patterns can be explained by automatic, cross-person priming. A key test case is structural priming: does exposure to one syntactic structure, in production or comprehension, make reuse of that structure (by the same or another speaker) more likely? It has been claimed that syntactic repetition caused by structural priming is ubiquitous in conversation. However, previous work has not tested for general syntactic repetition effects in ordinary conversation independently of lexical repetition. Here we analyse patterns of syntactic repetition in two large corpora of unscripted everyday conversations. Our results show that when lexical repetition is taken into account there is no general tendency for people to repeat their own syntactic constructions. More importantly, people repeat each other's syntactic constructions less than would be expected by chance; i.e., people systematically diverge from one another in their use of syntactic constructions. We conclude that in ordinary conversation the structural priming effects described in the literature are overwhelmed by the need to actively engage with our conversational partners and respond productively to what they say. PMID:24919186

  7. A Teaching Aids Exhibition.

    ERIC Educational Resources Information Center

    Mahanja, Salah

    1985-01-01

    Describes an exhibition for the benefit of teachers of English in Arab Primary Schools, which was prepared by third-year students at the Teachers College for Arab Teachers. The exhibition included games, songs, audiovisual aids, crossword puzzles, vocabulary, spelling booklets, preposition aids, and worksheet and lesson planning aids. (SED)

  8. San Rafael Schools Exhibit.

    ERIC Educational Resources Information Center

    San Rafael City Schools, CA.

    The San Rafael City Schools' exhibit which was displayed at the 1983 Marin County Fair (California) is described. The exhibit, entitled "Education - A Real Winner," consisted of 12 display panels illustrating the following aspects of the school system: (1) early history from 1861; (2) present board and administration; (3) present schools and…

  9. Visitors Center Exhibits

    NASA Technical Reports Server (NTRS)

    1997-01-01

    A child enjoys building his own LEGO model at a play table which was included in the exhibit 'Travel in Space' World Show. The exhibit consisted of 21 displays designed to teach children about flight and space travel from the Wright brothers to future generations of space vehicles.

  10. 43 CFR 3195.37 - Under what circumstances can BLM terminate me as an authorized Federal helium supplier?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... me as an authorized Federal helium supplier? 3195.37 Section 3195.37 Public Lands: Interior... MINERALS MANAGEMENT (3000) HELIUM CONTRACTS Federal Helium Supplier Requirements § 3195.37 Under what circumstances can BLM terminate me as an authorized Federal helium supplier? BLM has the authority to...

  11. 43 CFR 3195.37 - Under what circumstances can BLM terminate me as an authorized Federal helium supplier?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... me as an authorized Federal helium supplier? 3195.37 Section 3195.37 Public Lands: Interior... MINERALS MANAGEMENT (3000) HELIUM CONTRACTS Federal Helium Supplier Requirements § 3195.37 Under what circumstances can BLM terminate me as an authorized Federal helium supplier? BLM has the authority to...

  12. 43 CFR 3195.37 - Under what circumstances can BLM terminate me as an authorized Federal helium supplier?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... me as an authorized Federal helium supplier? 3195.37 Section 3195.37 Public Lands: Interior... MINERALS MANAGEMENT (3000) HELIUM CONTRACTS Federal Helium Supplier Requirements § 3195.37 Under what circumstances can BLM terminate me as an authorized Federal helium supplier? BLM has the authority to...

  13. 43 CFR 3195.37 - Under what circumstances can BLM terminate me as an authorized Federal helium supplier?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... me as an authorized Federal helium supplier? 3195.37 Section 3195.37 Public Lands: Interior... MINERALS MANAGEMENT (3000) HELIUM CONTRACTS Federal Helium Supplier Requirements § 3195.37 Under what circumstances can BLM terminate me as an authorized Federal helium supplier? BLM has the authority to...

  14. 43 CFR 3715.3-4 - How will BLM notify me of the outcome of its review process?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... its review process? 3715.3-4 Section 3715.3-4 Public Lands: Interior Regulations Relating to Public...) PUBLIC LAW 167; ACT OF JULY 23, 1955 Use and Occupancy Under the Mining Laws § 3715.3-4 How will BLM notify me of the outcome of its review process? At the conclusion of the review, BLM will make a...

  15. 43 CFR 3809.432 - What process will BLM follow in reviewing a modification of my plan of operations?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false What process will BLM follow in reviewing... MINERALS MANAGEMENT (3000) MINING CLAIMS UNDER THE GENERAL MINING LAWS Surface Management Modifications of Plans of Operations § 3809.432 What process will BLM follow in reviewing a modification of my plan...

  16. 43 CFR 3601.43 - What is the process for BLM to approve my mining and reclamation plans?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... § 3601.43 What is the process for BLM to approve my mining and reclamation plans? (a) After reviewing... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false What is the process for BLM to approve my mining and reclamation plans? 3601.43 Section 3601.43 Public Lands: Interior Regulations Relating...

  17. 43 CFR 3715.3-4 - How will BLM notify me of the outcome of its review process?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... its review process? 3715.3-4 Section 3715.3-4 Public Lands: Interior Regulations Relating to Public...) PUBLIC LAW 167; ACT OF JULY 23, 1955 Use and Occupancy Under the Mining Laws § 3715.3-4 How will BLM notify me of the outcome of its review process? At the conclusion of the review, BLM will make a...

  18. 43 CFR 3715.3-4 - How will BLM notify me of the outcome of its review process?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... its review process? 3715.3-4 Section 3715.3-4 Public Lands: Interior Regulations Relating to Public...) PUBLIC LAW 167; ACT OF JULY 23, 1955 Use and Occupancy Under the Mining Laws § 3715.3-4 How will BLM notify me of the outcome of its review process? At the conclusion of the review, BLM will make a...

  19. 43 CFR 3601.43 - What is the process for BLM to approve my mining and reclamation plans?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... § 3601.43 What is the process for BLM to approve my mining and reclamation plans? (a) After reviewing... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false What is the process for BLM to approve my mining and reclamation plans? 3601.43 Section 3601.43 Public Lands: Interior Regulations Relating...

  20. 43 CFR 3809.432 - What process will BLM follow in reviewing a modification of my plan of operations?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false What process will BLM follow in reviewing... MINERALS MANAGEMENT (3000) MINING CLAIMS UNDER THE GENERAL MINING LAWS Surface Management Modifications of Plans of Operations § 3809.432 What process will BLM follow in reviewing a modification of my plan...

  1. 43 CFR 3809.432 - What process will BLM follow in reviewing a modification of my plan of operations?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false What process will BLM follow in reviewing... MINERALS MANAGEMENT (3000) MINING CLAIMS UNDER THE GENERAL MINING LAWS Surface Management Modifications of Plans of Operations § 3809.432 What process will BLM follow in reviewing a modification of my plan...

  2. 43 CFR 3601.43 - What is the process for BLM to approve my mining and reclamation plans?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... § 3601.43 What is the process for BLM to approve my mining and reclamation plans? (a) After reviewing... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false What is the process for BLM to approve my mining and reclamation plans? 3601.43 Section 3601.43 Public Lands: Interior Regulations Relating...

  3. 43 CFR 3809.411 - What action will BLM take when it receives my plan of operations?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... undue degradation. (c) Following receipt of your complete plan of operations and before BLM acts on it... undue degradation. BLM may require you to incorporate into your plan of operations other agency permits... would result in unnecessary or undue degradation of public lands....

  4. 43 CFR 3809.411 - What action will BLM take when it receives my plan of operations?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... undue degradation. (c) Following receipt of your complete plan of operations and before BLM acts on it... undue degradation. BLM may require you to incorporate into your plan of operations other agency permits... would result in unnecessary or undue degradation of public lands....

  5. 43 CFR 3280.5 - May BLM require the modification of lease requirements in connection with the creation and...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... requirements in connection with the creation and operation of a unit agreement? 3280.5 Section 3280.5 Public... with the creation and operation of a unit agreement? (a) BLM may, with the consent of the lessees... connection with the creation and operation of any such unit agreement as BLM may consider necessary...

  6. 43 CFR 3280.5 - May BLM require the modification of lease requirements in connection with the creation and...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... requirements in connection with the creation and operation of a unit agreement? 3280.5 Section 3280.5 Public... with the creation and operation of a unit agreement? (a) BLM may, with the consent of the lessees... connection with the creation and operation of any such unit agreement as BLM may consider necessary...

  7. 43 CFR 3280.5 - May BLM require the modification of lease requirements in connection with the creation and...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... requirements in connection with the creation and operation of a unit agreement? 3280.5 Section 3280.5 Public... with the creation and operation of a unit agreement? (a) BLM may, with the consent of the lessees... connection with the creation and operation of any such unit agreement as BLM may consider necessary...

  8. 43 CFR 3809.591 - What are the limitations on the amount by which BLM may reduce my financial guarantee?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Financial Guarantee § 3809.591 What are the limitations on the amount by which BLM may reduce my financial... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false What are the limitations on the amount by which BLM may reduce my financial guarantee? 3809.591 Section 3809.591 Public Lands:...

  9. 43 CFR 3809.591 - What are the limitations on the amount by which BLM may reduce my financial guarantee?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Financial Guarantee § 3809.591 What are the limitations on the amount by which BLM may reduce my financial... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false What are the limitations on the amount by which BLM may reduce my financial guarantee? 3809.591 Section 3809.591 Public Lands:...

  10. 43 CFR 3809.591 - What are the limitations on the amount by which BLM may reduce my financial guarantee?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Financial Guarantee § 3809.591 What are the limitations on the amount by which BLM may reduce my financial... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false What are the limitations on the amount by which BLM may reduce my financial guarantee? 3809.591 Section 3809.591 Public Lands:...

  11. 43 CFR 3809.591 - What are the limitations on the amount by which BLM may reduce my financial guarantee?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Financial Guarantee § 3809.591 What are the limitations on the amount by which BLM may reduce my financial... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false What are the limitations on the amount by which BLM may reduce my financial guarantee? 3809.591 Section 3809.591 Public Lands:...

  12. 43 CFR 3280.5 - May BLM require the modification of lease requirements in connection with the creation and...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... requirements in connection with the creation and operation of a unit agreement? 3280.5 Section 3280.5 Public... with the creation and operation of a unit agreement? (a) BLM may, with the consent of the lessees... connection with the creation and operation of any such unit agreement as BLM may consider necessary...

  13. 43 CFR 3509.48 - What will BLM do after it receives my application for a fractional interest lease?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false What will BLM do after it receives my application for a fractional interest lease? 3509.48 Section 3509.48 Public Lands: Interior Regulations... Lease Applications § 3509.48 What will BLM do after it receives my application for a fractional...

  14. 43 CFR 3509.18 - What will BLM do after it receives my application for a future interest lease?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false What will BLM do after it receives my application for a future interest lease? 3509.18 Section 3509.18 Public Lands: Interior Regulations Relating... Applications § 3509.18 What will BLM do after it receives my application for a future interest lease? (a)...

  15. 43 CFR 3512.11 - Once BLM issues me a permit or lease, may I assign or sublease it?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Once BLM issues me a permit or lease, may I assign or sublease it? 3512.11 Section 3512.11 Public Lands: Interior Regulations Relating to... § 3512.11 Once BLM issues me a permit or lease, may I assign or sublease it? You may assign or...

  16. 43 CFR 3509.18 - What will BLM do after it receives my application for a future interest lease?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false What will BLM do after it receives my application for a future interest lease? 3509.18 Section 3509.18 Public Lands: Interior Regulations Relating... Applications § 3509.18 What will BLM do after it receives my application for a future interest lease? (a)...

  17. 43 CFR 3509.48 - What will BLM do after it receives my application for a fractional interest lease?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false What will BLM do after it receives my application for a fractional interest lease? 3509.48 Section 3509.48 Public Lands: Interior Regulations... Lease Applications § 3509.48 What will BLM do after it receives my application for a fractional...

  18. 43 CFR 3512.11 - Once BLM issues me a permit or lease, may I assign or sublease it?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Once BLM issues me a permit or lease, may I assign or sublease it? 3512.11 Section 3512.11 Public Lands: Interior Regulations Relating to... § 3512.11 Once BLM issues me a permit or lease, may I assign or sublease it? You may assign or...

  19. Communicating Science through Exhibitions

    NASA Astrophysics Data System (ADS)

    Dusenbery, P.; Harold, J.; Morrow, C.

    It is critically important for the public to better understand the scientific process. Museum exhibitions are an important part of informal science education that can effectively reach public audiences as well as school groups. They provide an important gateway for the public to learn about compelling scientific endeavors. There are many ways for scientists to help develop science exhibitions. The Space Science Institute (SSI) is a national leader in producing traveling science exhibitions and their associated educational programming (i.e. interactive websites, educator workshops, public talks, instructional materials). Two of its exhibitions, Space Weather Center and MarsQuest, are currently on tour. Another exhibition, Alien Earths, is in development. The Space Weather Center was developed in partnership with various research missions at NASA's Goddard Space Flight Center. MarsQuest is a 5000 square-foot traveling exhibition. The exhibit's second 3-year tour began this January at the Detroit Science Center. It is enabling millions of Americans to share in the excitement of the scientific exploration of Mars and to learn more about their own planet in the process. The 3,000 square-foot traveling exhibition, called Alien Earths, will bring origins-related research and discoveries to students and the American public. Alien Earths has four interrelated exhibit areas: Our Place in Space, Star Birth, PlanetQuest, and Search for Life. Exhibit visitors will explore the awesome events surrounding the birth of stars and planets; they will join scientists in the hunt for planets outside our solar system including those that may be in ``habitable zones'' around other stars; and finally they will be able to learn about how scientists are looking for signs of life beyond Earth. Besides the exhibits, SSI is also developing interactive web sites based on exhibit themes. New technologies are transforming the Web from a static medium to an interactive environment with tremendous

  20. Genetic and phenotypic divergence between low- and high-altitude populations of two recently diverged cinnamon teal subspecies.

    PubMed

    Wilson, Robert E; Peters, Jeffrey L; McCracken, Kevin G

    2013-01-01

    Spatial variation in the environment can lead to divergent selection between populations occupying different parts of a species' range, and ultimately lead to population divergence. The colonization of new areas can thus facilitate divergence in beneficial traits, yet with little differentiation at neutral genetic markers. We investigated genetic and phenotypic patterns of divergence between low- and high-altitude populations of cinnamon teal inhabiting normoxic and hypoxic regions in the Andes and adjacent lowlands of South America. Cinnamon teal showed strong divergence in body size (PC1; P(ST) = 0.56) and exhibited significant frequency differences in a single nonsynonymous α-hemoglobin amino acid polymorphism (Asn/Ser-α9; F(ST) = 0.60) between environmental extremes, despite considerable admixture of mtDNA and intron loci (F(ST) = 0.004-0.168). Inferences of strong population segregation were further supported by the observation of few mismatched individuals in either environmental extreme. Coalescent analyses indicated that the highlands were most likely colonized from lowland regions but following divergence, gene flow has been asymmetric from the highlands into the lowlands. Multiple selection pressures associated with high-altitude habitats, including cold and hypoxia, have likely shaped morphological and genetic divergence within South American cinnamon teal populations. PMID:23289570

  1. 78 FR 65356 - Notice of Mailing/Street Address Change for the BLM-Utah West Desert District and Salt Lake Field...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-31

    ... Bureau of Land Management Notice of Mailing/Street Address Change for the BLM-Utah West Desert District... mailing/street address for the Bureau of Land Management (BLM), West Desert District and Salt Lake Field... FURTHER INFORMATION CONTACT: Jared Posey, Administrative Officer, BLM West Desert District Office, at...

  2. 43 CFR 2884.24 - What fees do I owe if BLM denies my application or if I withdraw my application?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false What fees do I owe if BLM denies my application or if I withdraw my application? 2884.24 Section 2884.24 Public Lands: Interior Regulations... fees do I owe if BLM denies my application or if I withdraw my application? If BLM denies...

  3. 43 CFR 2804.27 - What fees do I owe if BLM denies my application or if I withdraw my application?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false What fees do I owe if BLM denies my application or if I withdraw my application? 2804.27 Section 2804.27 Public Lands: Interior Regulations....27 What fees do I owe if BLM denies my application or if I withdraw my application? If BLM...

  4. 43 CFR 3830.8 - How will BLM use the information it collects and what does it estimate the burden is on the public?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false How will BLM use the information it collects and what does it estimate the burden is on the public? 3830.8 Section 3830.8 Public Lands... PROVISIONS Providing Information to BLM § 3830.8 How will BLM use the information it collects and what...

  5. 43 CFR 3830.8 - How will BLM use the information it collects and what does it estimate the burden is on the public?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false How will BLM use the information it collects and what does it estimate the burden is on the public? 3830.8 Section 3830.8 Public Lands... PROVISIONS Providing Information to BLM § 3830.8 How will BLM use the information it collects and what...

  6. 43 CFR 3830.8 - How will BLM use the information it collects and what does it estimate the burden is on the public?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false How will BLM use the information it collects and what does it estimate the burden is on the public? 3830.8 Section 3830.8 Public Lands... PROVISIONS Providing Information to BLM § 3830.8 How will BLM use the information it collects and what...

  7. 43 CFR 3830.8 - How will BLM use the information it collects and what does it estimate the burden is on the public?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false How will BLM use the information it collects and what does it estimate the burden is on the public? 3830.8 Section 3830.8 Public Lands... PROVISIONS Providing Information to BLM § 3830.8 How will BLM use the information it collects and what...

  8. New Hurricane Exhibit

    NASA Technical Reports Server (NTRS)

    2007-01-01

    A new exhibit in StenniSphere depicting NASA's role in hurricane prediction and research and SSC's role in helping the region recover from Hurricane Katrina. The cyclone-shaped exhibit focuses on the effects of the Aug. 29, 2005 storm and outlines how NASA is working to improve weather forecasting. Through photos, 3-D models and digital animations, the exhibit tells the story of what happened inside the storm and how NASA's scientific research can increase the accuracy of hurricane tracking and modeling.

  9. Nucleosomes Shape DNA Polymorphism and Divergence

    PubMed Central

    Langley, Sasha A.; Karpen, Gary H.; Langley, Charles H.

    2014-01-01

    An estimated 80% of genomic DNA in eukaryotes is packaged as nucleosomes, which, together with the remaining interstitial linker regions, generate higher order chromatin structures [1]. Nucleosome sequences isolated from diverse organisms exhibit ∼10 bp periodic variations in AA, TT and GC dinucleotide frequencies. These sequence elements generate intrinsically curved DNA and help establish the histone-DNA interface. We investigated an important unanswered question concerning the interplay between chromatin organization and genome evolution: do the DNA sequence preferences inherent to the highly conserved histone core exert detectable natural selection on genomic divergence and polymorphism? To address this hypothesis, we isolated nucleosomal DNA sequences from Drosophila melanogaster embryos and examined the underlying genomic variation within and between species. We found that divergence along the D. melanogaster lineage is periodic across nucleosome regions with base changes following preferred nucleotides, providing new evidence for systematic evolutionary forces in the generation and maintenance of nucleosome-associated dinucleotide periodicities. Further, Single Nucleotide Polymorphism (SNP) frequency spectra show striking periodicities across nucleosomal regions, paralleling divergence patterns. Preferred alleles occur at higher frequencies in natural populations, consistent with a central role for natural selection. These patterns are stronger for nucleosomes in introns than in intergenic regions, suggesting selection is stronger in transcribed regions where nucleosomes undergo more displacement, remodeling and functional modification. In addition, we observe a large-scale (∼180 bp) periodic enrichment of AA/TT dinucleotides associated with nucleosome occupancy, while GC dinucleotide frequency peaks in linker regions. Divergence and polymorphism data also support a role for natural selection in the generation and maintenance of these super

  10. Test Control Center exhibit

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Have you ever wondered how the engineers at John C. Stennis Space Center in Hancock County, Miss., test fire a Space Shuttle Main Engine? The Test Control Center exhibit at StenniSphere can answer your questions by simulating the test firing of a Space Shuttle Main Engine. A recreation of one of NASA's test control centers, the exhibit explains and portrays the 'shake, rattle and roar' that happens during a real test firing.

  11. Communicating Science through Exhibitions

    NASA Astrophysics Data System (ADS)

    Dusenbery, Paul

    2005-04-01

    It is critically important for the public to better understand the scientific process. Museum exhibitions are an important part of informal science education that can effectively reach public audiences as well as school groups. They provide an important gateway for the public to learn about compelling scientific endeavors. Science exhibitions also provide a marvelous opportunity for scientists to become engaged in the exhibit development process. The Space Science Institute (SSI) is a national leader in producing traveling science exhibitions and their associated educational programming (i.e. interactive websites, educator workshops, public talks, instructional materials). The focus of this presentation will be on two of its exhibit projects: MarsQuest (on tour for four years) and Alien Earths (its tour began early in 2005). MarsQuest is enabling millions of Americans to share in the excitement of the scientific exploration of Mars and to learn more about their own planet in the process. Alien Earths will bring origins-related research and discoveries to students and the American public. It has four interrelated exhibit areas: Our Place in Space, Star Birth, Planet Quest, and Search for Life. Exhibit visitors will explore the awesome events surrounding the birth of stars and planets; they will join scientists in the hunt for planets outside our solar system including those that may be in ``habitable zones'' around other stars; and finally they will be able to learn about how scientists are looking for signs of life beyond Earth. SSI is also developing interactive web sites based on exhibit themes. New technologies are transforming the Web from a static medium to an interactive environment with tremendous potential for informal education and inquiry-based investigations. This talk will focus on the role informal science projects play in effectively communicating science to a broad, public audience.

  12. Infrared divergences in de Sitter space

    SciTech Connect

    Polarski, D. Service d'Astrophysique, CEN Saclay, 91191 Gif-sur-Yvette CEDEX, France)

    1991-03-15

    Infrared divergences in de Sitter space are considered. It is shown that symmetry breaking is unavoidable only when the infrared divergence is strong enough. The static vacuum has no symmetry breaking despite the presence of an infrared divergence.

  13. Divergent/passive margin basins

    SciTech Connect

    Edwards, J.D. ); Santogrossi, P.A. )

    1989-01-01

    This book discusses the detailed geology of the four divergent margin basins and establishes a set of analog scenarios which can be used for future petroleum exploration. The divergent margin basins are the Campos basin of Brazil, the Gabon basin, the Niger delta, and the basins of the northwest shelf of Australia. These four petroleum basins present a wide range of stratigraphic sequences and structural styles that represent the diverse evolution of this large and important class of world petroleum basins.

  14. Swamp to Space exhibit

    NASA Technical Reports Server (NTRS)

    2000-01-01

    The menacing-looking alligator is really harmless. It is one of the realistic props to help convince visitors that the feel of the swamp is real in StenniSphere's Swamp to Space exhibit at John C. Stennis Space Center in Hancock County, Miss. The historical section of the Swamp to Space exhibit tells the story of why and how Stennis Space Center came to be. It also pays tribute to the families who moved their homes to make way for the space age in Mississippi.

  15. 43 CFR 3715.6 - What things does BLM prohibit under this subpart?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... required under 43 CFR part 3800, subparts 3802 or 3809; (c) Beginning occupancy before consultation with BLM as required by § 3715.3 for activities that do not require a plan of operations under 43 CFR part 3800, subpart 3802 or that are defined as casual use or notice activities under 43 CFR part...

  16. 43 CFR 3715.6 - What things does BLM prohibit under this subpart?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... required under 43 CFR part 3800, subparts 3802 or 3809; (c) Beginning occupancy before consultation with BLM as required by § 3715.3 for activities that do not require a plan of operations under 43 CFR part 3800, subpart 3802 or that are defined as casual use or notice activities under 43 CFR part...

  17. 43 CFR 3715.6 - What things does BLM prohibit under this subpart?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... required under 43 CFR part 3800, subparts 3802 or 3809; (c) Beginning occupancy before consultation with BLM as required by § 3715.3 for activities that do not require a plan of operations under 43 CFR part 3800, subpart 3802 or that are defined as casual use or notice activities under 43 CFR part...

  18. 43 CFR 5040.1 - Under what authority does BLM establish sustained-yield forest units?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... sustained-yield forest units? 5040.1 Section 5040.1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR FOREST MANAGEMENT (5000) SUSTAINED-YIELD FOREST UNITS § 5040.1 Under what authority does BLM establish sustained-yield forest...

  19. 43 CFR 5040.1 - Under what authority does BLM establish sustained-yield forest units?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... sustained-yield forest units? 5040.1 Section 5040.1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR FOREST MANAGEMENT (5000) SUSTAINED-YIELD FOREST UNITS § 5040.1 Under what authority does BLM establish sustained-yield forest...

  20. 43 CFR 5040.1 - Under what authority does BLM establish sustained-yield forest units?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... sustained-yield forest units? 5040.1 Section 5040.1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR FOREST MANAGEMENT (5000) SUSTAINED-YIELD FOREST UNITS § 5040.1 Under what authority does BLM establish sustained-yield forest...

  1. 43 CFR 5040.3 - How does BLM establish sustained-yield forest units?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... forest units? 5040.3 Section 5040.3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR FOREST MANAGEMENT (5000) SUSTAINED-YIELD FOREST UNITS § 5040.3 How does BLM establish sustained-yield forest units? After a public hearing,...

  2. 43 CFR 5040.3 - How does BLM establish sustained-yield forest units?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... forest units? 5040.3 Section 5040.3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR FOREST MANAGEMENT (5000) SUSTAINED-YIELD FOREST UNITS § 5040.3 How does BLM establish sustained-yield forest units? After a public hearing,...

  3. 43 CFR 5040.1 - Under what authority does BLM establish sustained-yield forest units?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... sustained-yield forest units? 5040.1 Section 5040.1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR FOREST MANAGEMENT (5000) SUSTAINED-YIELD FOREST UNITS § 5040.1 Under what authority does BLM establish sustained-yield forest...

  4. 43 CFR 5040.3 - How does BLM establish sustained-yield forest units?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... forest units? 5040.3 Section 5040.3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR FOREST MANAGEMENT (5000) SUSTAINED-YIELD FOREST UNITS § 5040.3 How does BLM establish sustained-yield forest units? After a public hearing,...

  5. 43 CFR 5040.3 - How does BLM establish sustained-yield forest units?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... forest units? 5040.3 Section 5040.3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR FOREST MANAGEMENT (5000) SUSTAINED-YIELD FOREST UNITS § 5040.3 How does BLM establish sustained-yield forest units? After a public hearing,...

  6. 43 CFR 3507.20 - May I appeal BLM's rejection of my preference right lease?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false May I appeal BLM's rejection of my preference right lease? 3507.20 Section 3507.20 Public Lands: Interior Regulations Relating to Public Lands... rejection of my preference right lease? Yes. You have a right to appeal under the procedures in parts 4...

  7. 43 CFR 3507.20 - May I appeal BLM's rejection of my preference right lease?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false May I appeal BLM's rejection of my preference right lease? 3507.20 Section 3507.20 Public Lands: Interior Regulations Relating to Public Lands... rejection of my preference right lease? Yes. You have a right to appeal under the procedures in parts 4...

  8. 43 CFR 3507.20 - May I appeal BLM's rejection of my preference right lease?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false May I appeal BLM's rejection of my preference right lease? 3507.20 Section 3507.20 Public Lands: Interior Regulations Relating to Public Lands... rejection of my preference right lease? Yes. You have a right to appeal under the procedures in parts 4...

  9. 43 CFR 3507.20 - May I appeal BLM's rejection of my preference right lease?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false May I appeal BLM's rejection of my preference right lease? 3507.20 Section 3507.20 Public Lands: Interior Regulations Relating to Public Lands... rejection of my preference right lease? Yes. You have a right to appeal under the procedures in parts 4...

  10. LOWER COEUR D'ALENE RIVER, IDAHO. A MANAGEMENT ANALYSIS OF BLM LANDS, 1990

    EPA Science Inventory

    This study was intended to provide guidance to BLM for future management of the Lower Coeur dAlene River area, Idaho (17010301, 17010303), giving full consideration to the potential environmental and human health issues in the river and its lateral lakes caused by the presence of...

  11. 43 CFR 3809.900 - Will BLM allow the public to visit mines on public lands?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Will BLM allow the public to visit mines on public lands? 3809.900 Section 3809.900 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT...

  12. 43 CFR 3809.900 - Will BLM allow the public to visit mines on public lands?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Will BLM allow the public to visit mines on public lands? 3809.900 Section 3809.900 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT...

  13. 43 CFR 3809.900 - Will BLM allow the public to visit mines on public lands?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Will BLM allow the public to visit mines on public lands? 3809.900 Section 3809.900 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT...

  14. 43 CFR 3809.900 - Will BLM allow the public to visit mines on public lands?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Will BLM allow the public to visit mines on public lands? 3809.900 Section 3809.900 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT...

  15. 43 CFR 2804.25 - How will BLM process my application?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... application under 43 CFR subpart 2804 for the generation of electricity from wind or solar sources. In... required by 40 CFR parts 1500 through 1508; (2) Determine whether or not your proposed use complies with... electricity generation from wind or solar sources under the BLM's right-of-way regulations. Upon...

  16. 43 CFR 3192.17 - Can BLM reinstate cooperative agreements that have been terminated?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... that have been terminated? 3192.17 Section 3192.17 Public Lands: Interior Regulations Relating to... Agreements § 3192.17 Can BLM reinstate cooperative agreements that have been terminated? (a) If your... prove that you have corrected the problem(s) and are able to carry out the terms of the agreement....

  17. 43 CFR 3192.17 - Can BLM reinstate cooperative agreements that have been terminated?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... that have been terminated? 3192.17 Section 3192.17 Public Lands: Interior Regulations Relating to... Agreements § 3192.17 Can BLM reinstate cooperative agreements that have been terminated? (a) If your... prove that you have corrected the problem(s) and are able to carry out the terms of the agreement....

  18. 43 CFR 3195.26 - What information must I report to BLM?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) HELIUM CONTRACTS Federal... Helium Sales Contract, within 45 days of the end of each quarter, you must report to BLM (see § 3195.13) the following: (a) The name of the company from which you purchased a major helium requirement;...

  19. 43 CFR 3195.26 - What information must I report to BLM?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) HELIUM CONTRACTS Federal... Helium Sales Contract, within 45 days of the end of each quarter, you must report to BLM (see § 3195.13) the following: (a) The name of the company from which you purchased a major helium requirement;...

  20. 43 CFR 3195.33 - What information must I report to BLM?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) HELIUM CONTRACTS Federal Helium Supplier Requirements § 3195.33 What information must I report to BLM? (a) In accordance with the In-Kind Crude Helium Sales Contract, within 45 days of the end of each quarter, you must report...

  1. 43 CFR 3195.26 - What information must I report to BLM?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) HELIUM CONTRACTS Federal... Helium Sales Contract, within 45 days of the end of each quarter, you must report to BLM (see § 3195.13) the following: (a) The name of the company from which you purchased a major helium requirement;...

  2. 43 CFR 3195.33 - What information must I report to BLM?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) HELIUM CONTRACTS Federal Helium Supplier Requirements § 3195.33 What information must I report to BLM? (a) In accordance with the In-Kind Crude Helium Sales Contract, within 45 days of the end of each quarter, you must report...

  3. 43 CFR 3195.33 - What information must I report to BLM?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) HELIUM CONTRACTS Federal Helium Supplier Requirements § 3195.33 What information must I report to BLM? (a) In accordance with the In-Kind Crude Helium Sales Contract, within 45 days of the end of each quarter, you must report...

  4. 43 CFR 3195.26 - What information must I report to BLM?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) HELIUM CONTRACTS Federal... Helium Sales Contract, within 45 days of the end of each quarter, you must report to BLM (see § 3195.13) the following: (a) The name of the company from which you purchased a major helium requirement;...

  5. 43 CFR 3195.33 - What information must I report to BLM?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) HELIUM CONTRACTS Federal Helium Supplier Requirements § 3195.33 What information must I report to BLM? (a) In accordance with the In-Kind Crude Helium Sales Contract, within 45 days of the end of each quarter, you must report...

  6. 43 CFR 3200.6 - What types of geothermal leases will BLM issue?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false What types of geothermal leases will BLM issue? 3200.6 Section 3200.6 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) GEOTHERMAL RESOURCE LEASING Geothermal Resource Leasing § 3200.6...

  7. 43 CFR 3263.14 - May BLM require me to abandon a well?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... for geothermal resource production, injection, or monitoring, or if we determine that the well is not... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false May BLM require me to abandon a well? 3263... LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) GEOTHERMAL RESOURCE LEASING...

  8. 43 CFR 3263.14 - May BLM require me to abandon a well?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... for geothermal resource production, injection, or monitoring, or if we determine that the well is not... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false May BLM require me to abandon a well? 3263... LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) GEOTHERMAL RESOURCE LEASING...

  9. 43 CFR 3263.14 - May BLM require me to abandon a well?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... for geothermal resource production, injection, or monitoring, or if we determine that the well is not... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false May BLM require me to abandon a well? 3263... LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) GEOTHERMAL RESOURCE LEASING...

  10. 43 CFR 3250.13 - What additional BLM orders or instructions govern exploration?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false What additional BLM orders or instructions govern exploration? 3250.13 Section 3250.13 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) GEOTHERMAL RESOURCE LEASING...