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Sample records for bo wang chen

  1. Corrigendum on: Wang H, Chen C, Li J, Yang X, Zhang H and Wang Z. Modified first dorsal metacarpal artery island flap for sensory reconstruction of thumb pulp defects. J Hand Surg Eur. 2016, 41: 177-84.

    PubMed

    2016-05-01

    The authors apologise for an error in the presentation of the affiliations of the authors of this published paper. The correct details are:Hui Wang(1,2*), Chao Chen(3*), Jun Li(4), Xiaoxi Yang(5), Hui Zhang(1,6), Zhiqiang Wang(1,7) (1)Graduate School, Southern Medical University, Guangzhou, Guangdong, PR China(2)The department of Hand Surgery, The Second Hospital of Tangshan, Tangshan, Hebei, PR China(3)The department of Orthopedics, Chinese PLA General Hospital, Beijing, PR China(4)The emergency department, The Second Hospital of Tangshan, Tangshan, Hebei, PR China(5)The department of traditional Chinese Medicine, College of traditional Chinese Medicine, North China University of Technology, Tangshan, Hebei, PR China(6)The department of Joint Surgery, The Second Hospital of Tangshan, Tangshan, Hebei, PR China(7)The department of Orthopaedics, Affiliated Hospital, North China University of Technology, Tangshan, Hebei, 063000, PR China*Hui Wang and Chao Chen contributed equally to this work. PMID:26936745

  2. News & Information President Chen Yiyu Meets with Omi Professor Wang Jie Meets with NSF Assistant Director Vice President Sun Jiaguang Visited Japan and Germany on International Evaluation Vice President Shen Wenqing Meets JST Delegation Vice President Wang Jie Meets with Vice President of the Royal Society of Edinburgh 12th Meeting of China-Korea Joint Committee for Basic Scientific Research Held Further Implement the Scientific Outlook for Development and Open up a New Prospect for Science Funding Panel Meeting for A3 Foresight Program 2008 held in Hangzhou Department Director's Fund for Earthquake Relief Vice President Shen Wenqing Meets IRRI Officials President Chen Yiyu Visits Taiwan Province NSFC VIP Attends the NSFC-JST Workshop 1st NSFC-JST Joint Evaluation for Funded Projects Ends Successfully NSFC Delegation Visits the U.S. Top Heads Meet at China-US Computer Science Leadership Summit President Chen Yiyu Met with Her Royal Highness Princess Maha Chari Sirindhorn of Thailand

    NASA Astrophysics Data System (ADS)

    2008-01-01

    President Chen Yiyu Meets with Omi Professor Wang Jie Meets with NSF Assistant Director Vice President Sun Jiaguang Visited Japan and Germany on International Evaluation Vice President Shen Wenqing Meets JST Delegation Vice President Wang Jie Meets with Vice President of the Royal Society of Edinburgh 12th Meeting of China-Korea Joint Committee for Basic Scientific Research Held Further Implement the Scientific Outlook for Development and Open up a New Prospect for Science Funding Panel Meeting for A3 Foresight Program 2008 held in Hangzhou Department Director's Fund for Earthquake Relief Vice President Shen Wenqing Meets IRRI Officials President Chen Yiyu Visits Taiwan Province NSFC VIP Attends the NSFC-JST Workshop 1st NSFC-JST Joint Evaluation for Funded Projects Ends Successfully NSFC Delegation Visits the U.S. Top Heads Meet at China-US Computer Science Leadership Summit President Chen Yiyu Met with Her Royal Highness Princess Maha Chari Sirindhorn of Thailand

  3. Comet Ge-Wang

    NASA Astrophysics Data System (ADS)

    Ge, Yong-liang; Wang, Qi; Han, Tao

    1990-03-01

    Comet Ge-Wang (1988o) was discovered by GE Yong-liang and WANG Qi at Xinglong Station of Beijing Observatory on 1988 November 4. We collected 13 observations of this comet in China and abroad and calculated its orbit. It passed the perihelion on 1988 May 23. Ephemerides up to 1991 April are given.

  4. Comet Ge-Wang

    NASA Astrophysics Data System (ADS)

    Ge, Yong-Liang; Wang, Qi; Han, Tao

    1989-03-01

    Comet Ge-Wang (1988o) was discovered by GE Yong-liang and WANG Qi at Xinglong Station of Beijing Observatory on November 4, 1988. Thirteen observations of this comet were collected in China and abroad and calculated its orbit. It passed the perihelion on May 23, 1988. Ephemerides up to April 1991 are given.

  5. Editorial: Which Wei Wang?

    SciTech Connect

    Sprouse, Gene D.

    2007-12-01

    The APS journals receive manuscripts from scientists all over the world. For authors whose names cannot be expressed in Latin characters, their names in the byline must be transliterated, a process that is not necessarily bidirectionally unique. For example, the eight Chinese names all transliterate as Wei Wang. To remove some of the ambiguity arising from this unfortunate degeneracy of names, APS will allow some authors the option to include their names in their own language in parentheses after the transliterated name, such as Wei Wang. The option to present names in the article byline in this manner is an experiment initially offered to Chinese, Japanese, and Korean authors, whose names can be expressed in Unicode characters. An example of a Japanese name is Tadanori Minamisono and a Korean name is Chang Kee Jung. In the English text the given name precedes the family name, while the reverse is true for the characters. As we gain experience, we may be able to broaden this offer to other languages. Authors who wish to try this option will need to prepare their manuscripts by following the special instructions at http://authors.aps.org/names.html.

  6. Heterotic Chen-Ruan cohomology

    NASA Astrophysics Data System (ADS)

    Manion, Ryan

    We extend the construction of the Chen-Ruan cohomology in the setting of heterotic string theory. We show that it properly reduces to the Chen-Ruan cohomology in the case where the gauge bundle E is chosen to be the tangent bundle TX and examine its basic properties, followed by demonstrating nontrivial examples and computations. The second portion of this work examines the extension of the anomaly cancellation condition for gerbes through an extended example. Namely, we use Fourier-Mukai transforms and the methods of [Donagi-Pantev 04] to set up a construction of bundles over a gerbe which should be non-anomalous.

  7. Wang-Landau Without Binning

    NASA Astrophysics Data System (ADS)

    Brown, G.; Nicholson, D.; Odbadrakh, Kh.; Eisenbach, M.; Rusanu, A.

    2012-02-01

    Results are presented for Wang-Landau calculations on a Heisenberg model of BCC Fe that describe the density of states as function defined for all accessible energies instead of a function tabulated at discrete values of the energy. The density of states function described here is an analytic result valid near the ground state supplemented by a polynomial expansion. The probability density of Wang-Landau random walkers is sampled for a fixed density of states, and that probability density can be used to improve the estimated density of states. Methods for evaluating the convergence of the density of states are discussed along with the diffusion behavior of the random walkers. This work was performed at the Oak Ridge National Laboratory, which is managed by UT-Battelle, LLC under Contract No. DE-AC05-00OR22725, and sponsored by the Laboratory Directed Research and Development Program (ORNL), by the Mathematical, Information, and Computational Sciences Division; Office of Advanced Scientific Computing Research (US DOE), and by the Division of Materials Sciences and Engineering; Office of Basic Energy Sciences (US DOE). Computer resources provided by Florida State University.

  8. Communicating between the Apple and the Wang

    SciTech Connect

    Barton, G.W., Downey, R.

    1982-10-26

    This manual covers what the beginner needs to know in order to transfer files between an Apple's Microcomputer and a Wang's OIS Word Processor. We have also tried to indicate where the experienced user might want to look for additional details. We cover the use of Apple Writer )(, VisiTerm, VisiCalc, and EasyWriter Professional. For us, the two most useful connections are from Applewriter to Wang and from Visicalc to Wang. From Wang to Apple Writer via Visiterm may have some value. Files can be transferred by VisiTerm to Wang, but they arrive with RETURNS in the middle of words, which have to be edited out, so we do not recommend it. We describe how to go from EasyWriter to Wang, but we do not know how to go from Wang to EasyWriter. We see no reason to go from Wang to VisiCalc, so we haven't thought about it. All instructions are given for a typical configuration of the Apple, namely the one on which this manual was composed. It is detailed in the section on Hardware and Software.

  9. Improved Chen-Smith image coder

    NASA Astrophysics Data System (ADS)

    Rubino, Eduardo M.; de Queiroz, Ricardo L.; Malvar, Henrique S.

    1995-04-01

    A new transform coder based on the zonal sampling strategy, which outperforms the JPEG baseline coder with comparable computational complexity, is presented. The primary transform used is the 8- x 8-pixel-block discrete cosine transform, although it can be replaced by other transforms, such as the lapped orthogonal transform, without any change in the algorithm. This coder is originally based on the Chen-Smith coder; therefore we call it an improved Chen-Smith (ICS) coder. However, because many new features were incorporated in this improved version, it largely outperforms its predecessor. Key approaches in the ICS coder, such as a new quantizer design, arithmetic coders, noninteger bit-rate allocation, decimalized variance maps, distance-based block classification, and human visual sensitivity weighting, are essential for its high performance, Image compression programs were developed and applied to several test images. The results show that the ICS performs substantially better than the JPEG coder.

  10. Generalized Chen-Wu type cosmological model

    NASA Astrophysics Data System (ADS)

    John, Moncy V.; Joseph, K. Babu

    2000-04-01

    Recent measurements require modifications in conventional cosmology by way of introducing components other than ordinary matter into the total energy density in the universe. On the basis of some dimensional considerations in line with quantum cosmology, Chen and Wu [W. Chen and Y. Wu, Phys. Rev. D 41, 695 (1990)] have argued that an additional component, which corresponds to an effective cosmological constant Λ, must vary as a-2 in the classical era. Their decaying-Λ model assumes inflation and yields a value for q0, which is not compatible with observations. We generalize this model by arguing that the Chen-Wu ansatz is applicable to the total energy density of the universe and not to Λ alone. The resulting model, which has a coasting evolution (i.e., a~t), is devoid of the problems of horizon, flatness, monopole, cosmological constant, size, age and generation of density perturbations. However, to avoid serious contradictions with big bang nucleosynthesis, the model has to make the predictions Ωm=4/3 and ΩΛ=2/3, which in turn are at variance with current observational values.

  11. [Chen Muhua announces nationwide census in 1982].

    PubMed

    1981-03-10

    A nationwide census, only the 3rd in the history of the People's Republic of China, will be taken in July 1982, announced Vice-Premier Chen Muhua at a meeting of the census office under the State Council which opened here today. The 1st census was conducted in 1953, and the 2nd in 1964. Chen, who is in charge of the census, told officials, population specialists and statisticians from across China it was unprecedented in both Chinese history and the history of the world to attempt to count a population that has been long estimated at 1 billion. The census has been proposed in order to ascertain a range of 20 demographic factors necessary for the effective administration of the current economic readjustment and China's modernization drive, the vice-premier said. It will assist family planning and population control, facilitate food and clothing supplies, and make possible assessment of construction needs--housing, hospitals, schools, and other public services, she continued. A great deal of trouble in planning and administration has been caused by the inadequacy of available figures, Chen said. The results will be calculated in 2 stages. Figures such as the number of households and people will be announced first, while other more precise breakdowns such as sex, age, nationality, education, marital status, and occupation will be available later. 2 experimental censuses were carried out in July, 1980. The 950,000 residents in both Wuxi City and Wuxi County in east China's Jiangsu Province, were surveyed. The conference, acting on reports and recommendations from these, will establish further experimental counts in the coming months, while preparatory procedures, organizational work, and regulations are to be discussed and consolidated. The 1982 nationwide census has the support of the UN's fund for population activities. PMID:12338073

  12. [Textual Research on Wang Fengchun's Life].

    PubMed

    Wang, Ti

    2012-01-01

    WANG Fengchun (1884 - 1949), born in Wu County, Jiangsu Province, was one of the four famous doctors of Beijing in the Republic of China periods. He learned Confucianism during his childhood and then learned medicine from AI Buchan, a famous doctor in Wuzhong area. In 1908, he went to Beijing and was appointed as the prosecutor of the court of law and a medical official, but also had learnt medicine from LI Jun, the head of the Business Ministry. In 1910, Wang resigned and lived as doctor in Beijing. According to the literature, from 1935 to 1942, Wang had been appointed 11 times as a member of Beiping (Beijing) TCM examination committee or test committee. In 1938, he was appointed as president of the Beijing Branch of the National Medical Professional Association and created the Beijing Medicine Monthly in 1939. In September 1939, Wang began to make preparations for a TCM symposium, i.e. the Medicine Symposium which was established officially in October 1939. In 1941, he was appointed as the director of the Beijing Traditional Chinese Medicines Workshop, employing famous doctors to cultivate reserve talents of medicines. Being a realist, he often exchanged opinions with TCM and western medical doctors and also made a contribution to medical education. PMID:22613482

  13. Free and Beautiful: Lucia Chen--New York Public Library

    ERIC Educational Resources Information Center

    Library Journal, 2004

    2004-01-01

    This article details the work of Lucia Chen of the New York Public Library. Lucia Chen combined her two passions--organization and beautification--in her recent project, creating an online version of the New York Public Library's (NYPL) legendary picture collection. Artists ranging from set designers to filmmakers have long used the collection,…

  14. Thermodynamic properties of gold nanoparticles described by Sutton-Chen potential and Quantum Sutton-Chen potential

    NASA Astrophysics Data System (ADS)

    Park, Yongjin; Carri, Gustavo

    2009-10-01

    Thermodynamic properties of gold nanoparticles (<1.6nm) have been investigated by atomistic Monte Carlo simulations with three different potential functions/parameterizations (Sutton-Chen potential, Sutton-Chen potential with Pawluk's parameterization, and Quantum Sutton-Chen potential). The melting temperature of gold nanoparticles is predicted and compared to other theoretical and experimental values. The agreement between the predicted melting temperatures and the experimental values was not satisfactory for any of the three potentials in the studied range of sizes. However, the Sutton-Chen potential showed very good agreement for nanoparticles larger than 1.3nm while the Quantum Sutton-Chen potential exhibited a trend of melting temperatures similar to the experimental one although it consistently overestimated the melting temperatures.

  15. [Probing the cause on Wang Qingrens idea of "Fallacious theory, effective prescription" of Wang Qingren].

    PubMed

    Pan, Da-wei

    2006-07-01

    The theory of human body in Yilin Gaicuo (Correction on Errors in Medical Classics) by Wang Qingren in late Qing Dynasty is different from that of traditional Chinese Medicine and that of anatomy of western medicine. However, the prescriptions recorded in Yilin Gaicuo (Correction on Errors in Medical Classics) are indeed effective clinically. The paradox of "Fallacious theory, effective prescription" suggests that the theories of Wang Qingren are not superficial in anatomy. By carefully analyzing the concept of zang-fu organs and concept of qi and blood as well as the theory of human body in Yilin Gaicuo (Correction on Errors in Medical Classics), although many viewpoints of theories of Wang Qingren deviates from that of traditional Chinese Medicine, they inherits the qi and blood concept, the core theory of Chinese Medicine. Therefore, the theories belong to the theoretical scope of Chinese Medicine. The root of "Fallacious theory, effective prescription" is in the heritage of the qi and blood concept. The set view of Wang Qingren in criticizing the theories of traditional Chinese Medicine and establishing new theories revealed in this process possesses the significance of revelation to the contemporary Chinese Medicine. PMID:17278444

  16. [Analysis of Wang Shuhe's academic contribution and epistemology].

    PubMed

    Meng, Qin-Yun

    2010-11-01

    Wang Shuhe is considered to be Zhang Zhongjing's disciple according to four reasons: A. the acquaintance of Yu Jiaxi and Fan Xingzhun and others. B. the close relation of Wang Shuhe and Wei Xun. C. Zhang Zhongjing's complete works kept by Wang Shuhe and Wang Shuhe's autobiography. D. the record in Maijing and that Wang Shuhe called Zhang Zhongjing master. It was speculated that Wang Shuhe was the minister of imperial medical affairs of the Wu Kingdom from the title of the emperor's reign recorded by Huang Fumi and Jingzhou's attribution. He contributed to Traditional Chinese Medicine in three aspects-preserving and classifying Zhang Zhongjng's complete works; preserving literature on pulse diagnosis, writing Maijing and standardizing methods for pulse-taking; and advancing the concept of syndrome and Bianzheng (transmutation with steaming in infant feverish perspiration), probing the theory of feverish diseases, and people's well-being, demonstrating the spirit of Bianzhenglunzhi. PMID:21223699

  17. Weighted Lin-Wang tests for crossing hazards.

    PubMed

    Koziol, James A; Jia, Zhenyu

    2014-01-01

    Lin and Wang have introduced a quadratic version of the logrank test, appropriate for situations in which the underlying survival distributions may cross. In this note, we generalize the Lin-Wang procedure to incorporate weights and investigate the performance of Lin and Wang's test and weighted versions in various scenarios. We find that weighting does increase statistical power in certain situations; however, none of the procedures was dominant under every scenario. PMID:24795776

  18. Analysis of parameters probability on Zhang-Wang signature scheme

    NASA Astrophysics Data System (ADS)

    Yang, Weiping; Liu, Chenglian

    2014-10-01

    Zhang and Wang proposed an improved signature scheme without using one-way hash functions. In this paper, we analyze the odd and even probability of signature parameters in Zhang-Wang signature scheme, which combined with Boolean algebra, such as bitwise exclusive-or (XOR). Furthermore, it is pointed out that we can use them for attacks.

  19. Bridging η2 -BO in B2(BO)3(-) and B3(BO)3(-) clusters: boronyl analogs of boranes.

    PubMed

    Zhai, Hua-Jin; Guo, Jin-Chang; Li, Si-Dian; Wang, Lai-Sheng

    2011-10-01

    Anion photoelectron spectroscopy and theoretical calculations are combined to probe the structures and chemical bonding of two boron-rich oxide clusters, B(5)O(3)(-) and B(6)O(3)(-), which are shown to be appropriately formulated as B(2)(BO)(3)(-) and B(3)(BO)(3)(-), respectively. The anion clusters are found to each possess a bridging η(2)-BO group, as well as two terminal BO groups and are analogs of B(2)H(3)(-) and B(3)H(3)(-). This finding advances the boronyl chemistry and helps establish the isolobal analogy between boron-rich oxide clusters and boranes. PMID:21954002

  20. Beauty and physics: 13 important contributions of Chen Ning Yang

    NASA Astrophysics Data System (ADS)

    Shi, Yu

    2014-06-01

    In 2012, Chen Ning Yang received a 90th birthday gift in the form of a black cube inscribed with his 13 most important contributions, which cover four major areas of physics: statistical mechanics, condensed matter physics, particle physics and field theory. We briefly describe these 13 contributions and make general comments about Yang's distinctive style as a trailblazing leader in research.

  1. [Study of dates of birth and death of WANG Tao].

    PubMed

    Song, Zhen-Min

    2011-03-01

    The dates of birth and death of WANG Tao, a famous doctor in Tang dynasty, are not found in literature and scholars have different points upon this subject. It could be sure that WANG Tao was appointed mayor of Huayuan county in the ninth year of Kaiyuan period (721) and in December of the fourteenth year of Tianbao period (756) he the revolt in Hejian. The recording after 756 could not be found in literature. According to the official system in Tang dynasty that officers retired at their age of 70, it could be sure that WANG Tao was less than 70 year old in 756. Considering his age when he was the county mayor in 721, it could be speculated that WANG Tao was born during the third year of Chuigong period (687) to the second year of Changshou period (693), and his death date should be some date after 756. But it couldn't be validated. PMID:21624275

  2. Chemical gas-dynamics beyond Wang Chang-Uhlenbeck's kinetics

    SciTech Connect

    Kolesnichenko, Evgeniy G.; Gorbachev, Yuriy E.

    2014-12-09

    Wang Chang-Uhlenbeck equation does not give possibility to take into account intermolecular processes such as redistribution of the energy among different degrees of freedom. The modification of the generalized Wang Chang-Uhlenbeck equation including such processes is proposed. It allows to study for instance the kinetics of non-radiative transitions. Limitations of this approach are connected with the requirements of absence of polarization of rotational momentum and phases of intermolecular vibrations.

  3. Massively parallel Wang Landau sampling on multiple GPUs

    SciTech Connect

    Yin, Junqi; Landau, D. P.

    2012-01-01

    Wang Landau sampling is implemented on the Graphics Processing Unit (GPU) with the Compute Unified Device Architecture (CUDA). Performances on three different GPU cards, including the new generation Fermi architecture card, are compared with that on a Central Processing Unit (CPU). The parameters for massively parallel Wang Landau sampling are tuned in order to achieve fast convergence. For simulations of the water cluster systems, we obtain an average of over 50 times speedup for a given workload.

  4. Spatial chaos of Wang tiles with two symbols

    NASA Astrophysics Data System (ADS)

    Chen, Jin-Yu; Chen, Yu-Jie; Hu, Wen-Guei; Lin, Song-Sun

    2016-02-01

    This investigation completely classifies the spatial chaos problem in plane edge coloring (Wang tiles) with two symbols. For a set of Wang tiles B , spatial chaos occurs when the spatial entropy h ( B ) is positive. B is called a minimal cycle generator if P ( B ) ≠ 0̸ and P ( B ' ) = 0̸ whenever B ' ⫋ B , where P ( B ) is the set of all periodic patterns on ℤ2 generated by B . Given a set of Wang tiles B , write B = C 1 ∪ C 2 ∪ ⋯ ∪ C k ∪ N , where Cj, 1 ≤ j ≤ k, are minimal cycle generators and B contains no minimal cycle generator except those contained in C1∪C2∪⋯∪Ck. Then, the positivity of spatial entropy h ( B ) is completely determined by C1∪C2∪⋯∪Ck. Furthermore, there are 39 equivalence classes of marginal positive-entropy sets of Wang tiles and 18 equivalence classes of saturated zero-entropy sets of Wang tiles. For a set of Wang tiles B , h ( B ) is positive if and only if B contains a MPE set, and h ( B ) is zero if and only if B is a subset of a SZE set.

  5. Dynamic states of a unidirectional ring of chen oscillators

    SciTech Connect

    Carvalho, Ana

    2015-03-10

    We study curious dynamical patterns appearing in a network of a unidirectional ring of Chen oscillators coupled to a ‘buffer’ cell. The network has Z{sub 3} exact symmetry group. We simulate the coupled cell systems associated to the two networks and obtain steady-states, rotating waves, quasiperiodic behavior, and chaos. The different patterns appear to arise through a sequence of Hopf, period-doubling and period-halving bifurcations. The network architecture appears to explain some patterns, whereas the properties of the chaotic oscillator may explain others. We use XPPAUT and MATLAB to compute numerically the relevant states.

  6. HyBoLT Flight Experiment

    NASA Technical Reports Server (NTRS)

    Chen, Fang-Jeng (Frank); Berry, Scott A.

    2010-01-01

    HyBoLT was a Hypersonic Boundary Layer Transition flight experiment funded by the Hypersonics Project of the Fundamental Aeronautics Program in NASA's Aeronautics Research Mission Directorate. The HyBoLT test article mounted on the top of the ALV X-1 rocket was launched from Virginia's Wallops Island on August 22, 2008. Unfortunately a problem in the rocket's flight control system caused the vehicle to veer off the designed flight course. Launch officials activated a self-destruct mechanism in the rocket's nose cone after 20 seconds into flight. This report is a closeout document about the HyBoLT flight experiment. Details are provided of the objectives and approach associated with this experimental program as well as the 20 seconds flight data acquired before the vehicle was destroyed.

  7. Registration of ‘BoMaster’ switchgrass

    Technology Transfer Automated Retrieval System (TEKTRAN)

    'BoMaster' switchgrass [Panicum virgatum L.] (Reg. no. CV-_____, PI 645256) was cooperatively developed by the USDA-Agricultural Research Service and the North Carolina Agricultural Research Service, North Carolina State University and released in 2006. The incorporation and preservation of the uniq...

  8. Asiago classification of ASASSN-15bo

    NASA Astrophysics Data System (ADS)

    Benetti, S.; Tomasella, L.; Cappellaro, E.; Elias-Rosa, N.; Ochner, P.; Pastorello, A.; Tartaglia, L.; Terreran, G.; Turatto, M.

    2015-02-01

    The Asiago Transient Classification Program (Tomasella et al. 2014, AN, 335, 841) reports the spectroscopic observation of ASASSN-15bo (ATel #6989). The observation was performed with the Asiago 1.82m Copernico Telescope (+AFOSC; range 340-820 nm; resolution 1.4 nm), equipped with the CCD Andor IKON L936.

  9. "Qi Yuling v. Chen Xiaoqi et al.": Judicial Interpretation by the Supreme People's Court

    ERIC Educational Resources Information Center

    Chinese Education and Society, 2006

    2006-01-01

    This article presents a reply to an inquiry regarding the Qi Yuling v. Chen Xiaoqi et al. case. The Supreme People's Court of China stated that by infringing on Qi Yuling's right to select and use her own name, Chen Xiaoqi et al. have violated Qi Yuling's fundamental constitutional right to education and have caused actual damages. Therefore, the…

  10. BoF - Python in Astronomy

    NASA Astrophysics Data System (ADS)

    Barrett, P. E.

    This BoF will be chaired by Paul Barrett and will begin with an introduction to Python in astronomy, be followed by reports of current Python projects, and conclude with a discussion about the current state of Python in astronomy. The introduction will give a brief overview of the language, highlighting modules, resources, and aspects of the language that are important to scientific programming and astronomical data analysis. The closing discussion will provide an opportunity for questions and comments.

  11. Minister Wang Wei on family planning policy and population aging.

    PubMed

    1987-01-01

    Mr. Wang Wei, Minister-in-Charge of the State Family Planning Commission, was interviewed by the correspondent of the magazine "Outlook Weekly" on the 16th of last July in Beijing. Mr. Wang Wei said that the aging process of China's population could not be separated from the family planning program which was an important factor leading to China's population aging. He also said that population aging in China would have its limit as any development does. The aging of China's population is the manifestation of the contradiction between the unplanned and planned reproduction of its population. Population aging will disappear as soon as the contradiction is settled. Since the aging of China's population is caused by the decrease of children, one cannot only see the social burden aggravated by the relative increase in elderly population but should also see the social burden alleviated by the decrease in the absolute number of children. Only by doing so can one see the whole picture. The allegation made by some people that the social dependency ratio would increase due to population aging is groundless. Mr. Wang Wei does not agree with the viewpoint that China may relax its policy of family planning to some extent on the ground that population aging causes the decrease in the total social dependency ratio so as to ease the difficulties brought about by the rapid population aging. The basic state policy of striving to quadruple the gross output value of industry and agriculture and to control China's population at about 1.2 billion at the end of the century is the correct policy to solve the problem of population aging in China, and it is also the only alternative. PMID:12268533

  12. Phonon spectra and temperature variation of bulk properties of Cu, Ag, Au and Pt using Sutton-Chen and modified Sutton-Chen potentials

    NASA Astrophysics Data System (ADS)

    Januszko, A.; Bose, S. K.

    2015-07-01

    Three potentials of the Finnis-Sinclair type are studied with regard to their suitability for predicting bulk thermal and elastic properties of fcc metals Cu, Ag, Au and Pt over a wide temperature range. We start with a particular parametrization of the Finnis-Sinclair model known as the Sutton-Chen potential and a later version of the same, known as the quantum Sutton-Chen potential. The quasiharmonic lattice dynamics method is used to study the temperature variation of the thermodynamic properties. Both models are found to yield poor results for thermal expansion, which can be traced to rapid softening of transverse phonon frequencies with increasing lattice parameter. The form of the Sutton-Chen potential is modified here to seek improvement in the agreement between quasiharmonic calculations and experimental data. It is found that the modified potential better predicts bulk properties in nearly all cases studied. Significant improvement is seen over the Sutton-Chen potential, while lesser but still substantial improvement is observed over the Quantum-Sutton Chen potential.

  13. Case 1. "Qi Yuling v. Chen Xiaoqi et al.": Opinion by the Higher People's Court of Shandong Province

    ERIC Educational Resources Information Center

    Chinese Education and Society, 2006

    2006-01-01

    This article presents the details of Qi Yuling v. Chen Xiaoqi et al case. The plaintiff Qi Yuling filed a lawsuit at the Intermediate People's Court in Zaozhuang, Shandong against defendants Chen Xiaoqi, Chen Kezheng, Jining Business School in Shandong ("Jining Business School"), the Eighth Middle School of Tengzhou, Shandong ("Tengzhou Eighth…

  14. B2(BO)6 0/- and B 2(BS) 6 0/- doubly bridged structures containing BO or BS as ligands.

    PubMed

    Li, Da-Zhi; Li, Si-Dian

    2014-09-01

    The investigation on the geometrical and electronic properties of B(2)(BO)(6) (0/-) and B(2)(BS)(6) (0/-) has been performed by density functional theory (DFT) using the B3LYP and BP86 methods. The chemical bonding in B(2)A(6) (A = H, BO, and BS) series is elucidated through the recently developed adaptive natural density partitioning (AdNDP). D(2h) B(2)(BO)(6) and B(2)(BS)(6) were found to possess two bridging η (2)-BO or η (2)-BS groups, as well as four terminal BO or BS groups that are analogs of diborane B(2)H(6). D(2)h B(2)(BO)(6) (-) and B(2)(BS)(6) (-) with two bridging η (2)-BO or η (2)-BS groups which are more stable than their corresponding D(3d) structures. The binding energy of B(2)(BO)(6) and B(2)(BS)(6) with respect to B(2)(BO)(6) (D2h) → 2B(BO)(3) (D(3h)) and B(2)(BS)(6)(D(2h)) → 2B(BS)(3) (D(3h)) are estimated to be (△)E = 19.8 and 40.6 kcal mol(-1) at CCSD(T)//B3LYP level, respectively. This finding advances the boronyl chemistry and helps establish the isolobal analogy between boron-rich oxide clusters and boranes. PMID:25159274

  15. Comment on ''Sensitivity Analysis and Determination of Streambed Leakance and Aquifer Hydraulic Properties'' by Xunhong Chen and Xi Chen, Journal of Hydrology, 2003, v.284, 270-284

    SciTech Connect

    Kollet, S

    2004-05-17

    Recently, studies of the Platte River watershed have gained significant attention from federal and Nebraska, USA, state agencies due to the importance of groundwater/surface-water interactions under drought conditions. Using archive data from a 1983 pumping test, Chen and Chen (2003) interpret the hydraulic properties of the alluvium and a streambed of the Platte River near Kearney, Nebraska, and compare their data with results of other studies performed over the past several years. Three important inconsistencies of this article will be highlighted here: (1) misuse of the analytical model of Hunt (1999), (2) departure of their results from previously published data, and (3) unsatisfactory explanation of these anomalous results.

  16. Aesthetic use of BoNT: Options and outcomes.

    PubMed

    Gendler, Ellen; Nagler, Arielle

    2015-12-01

    There are a multitude of uses for BoNT in the aesthetic realm. Efficacy has been shown in softening glabellar creases, crows feet, forehead rhytides, and in correcting facial asymmetries, including mild eyelid ptosis. Facial shape can be altered through injections of BoNT into masseter, and smiles can be altered with BoNT. Clinical examples of the above will be shown, as well as adverse outcomes with inaccurate injection techniques. PMID:26368007

  17. Ke Wang, a Chinese television soap opera with a message.

    PubMed

    Wang, M; Singhal, A

    1992-01-01

    The Chinese soap opera, Ke Wang, was created by Li Xiaoming between August 1989 and June 1990 and produced at a cost of US$4650 per episode. The characters were drawn from everyday ordinary Chinese life: a traditional and open-minded and caring woman, a typical mother who works hard and loves her children, a highly educated upwardly mobile man who divorces his wife, a professor criticized during the Cultural Revolution, a doctor prejudiced against ordinary people, a kind honest man who marries the divorcee, a friend of the divorcee, a man who is optimistic in spite of bad experiences during the Cultural Revolution, and an excellent medical doctor who also resolves conflicts. The program was very popular, even among Communists, because of its value-based content, the real-life nature of the show, the change from highly restricted programming, the elaborate and supportive media coverage, and dialogue which closely matches audience preferences. The show has been aired by over 100 stations to date and has reached a total estimated audience of 550 million. The sale of television sets has increased since the show's appearance. The script reflects the conflicts between traditional and modern Chinese values. Pro-social values and behaviors are learned from the role models depicted; examples are given of immediate social impact. Ke Wang was a by-product of the Beijing Television Arts Center's interest in designing television programs that are relevant to the lives of ordinary people. The 60-minute scripts dealt with issues such as the status of women, social morality, family harmony, class conflict, responsible parenthood, maintenance of traditional culture, volunteerism, child development, and coping with physical disability. The Chinese government hailed Ke Wang as model television and awarded US$20,000 in prize money to the producers. The Chinese government is planning to produce other entertainment-education soap operas, which raises the problem of blatant, political

  18. Synthetic lipophilic antioxidant BO-653 suppresses HCV replication.

    PubMed

    Yasui, Fumihiko; Sudoh, Masayuki; Arai, Masaaki; Kohara, Michinori

    2013-02-01

    The influence of the intracellular redox state on the hepatitis C virus (HCV) life cycle is poorly understood. This study demonstrated the anti-HCV activity of 2,3-dihydro-5-hydroxy-2,2-dipentyl-4,6-di-tert-butylbenzofuran (BO-653), a synthetic lipophilic antioxidant, and examined whether BO-653's antioxidant activity is integral to its anti-HCV activity. The anti-HCV activity of BO-653 was investigated in HuH-7 cells bearing an HCV subgenomic replicon (FLR3-1 cells) and in HuH-7 cells infected persistently with HCV (RMT-tri cells). BO-653 inhibition of HCV replication was also compared with that of several hydrophilic and lipophilic antioxidants. BO-653 suppressed HCV replication in FLR3-1 and RMT-tri cells in a concentration-dependent manner. The lipophilic antioxidants had stronger anti-HCV activities than the hydrophilic antioxidants, and BO-653 displayed the strongest anti-HCV activity of all the antioxidants examined. Therefore, the anti-HCV activity of BO-653 was examined in chimeric mice harboring human hepatocytes infected with HCV. The combination treatment of BO-653 and polyethylene glycol-conjugated interferon-α (PEG-IFN) decreased serum HCV RNA titer more than that seen with PEG-IFN alone. These findings suggest that both the lipophilic property and the antioxidant activity of BO-653 play an important role in the inhibition of HCV replication. PMID:23192857

  19. Bridge Between the Hyperchaotic Lorenz System and the Hyperchaotic Chen System

    NASA Astrophysics Data System (ADS)

    Ma, Chao; Wang, Xingyuan

    This paper presents a novel unified hyperchaotic system that contains the hyperchaotic Lorenz system and the hyperchaotic Chen system as two dual systems at the two extremes of its parameter spectrum. The new system is hyperchaotic over almost the whole range of the system parameter and continuously transfers from the hyperchaotic Lorenz system to the hyperchaotic Chen system. The new findings are not only demonstrated by computer simulations but also verified with bifurcation analysis, Lyapunov exponents and Lyapunov dimension.

  20. Wang-Landau simulation of Gō model molecules.

    PubMed

    Böker, Arne; Paul, Wolfgang

    2016-01-01

    Gō-like models are one of the oldest protein modeling concepts in computational physics and have proven their value over and over for forty years. The essence of a Gō model is to define a native contact matrix for a well-defined low-energy polymer configuration, e.g., the native state in the case of proteins or peptides. Many different potential shapes and many different cut-off distances in the definition of this native contact matrix have been proposed and applied. We investigate here the physical consequences of the choice for this cut-off distance in the Gō models derived for a square-well tangent sphere homopolymer chain. For this purpose we are performing flat-histogram Monte Carlo simulations of Wang-Landau type, obtaining the thermodynamic and structural properties of such models over the complete temperature range. Differences and similarities with Gō models for proteins and peptides are discussed. PMID:26810395

  1. Multiple Walkers in the Wang-Landau Algorithm

    SciTech Connect

    Brown, G

    2005-12-28

    The mean cost for converging an estimated density of states using the Wang-Landau algorithm is measured for the Ising and Heisenberg models. The cost increases in a power-law fashion with the number of spins, with an exponent near 3 for one-dimensional models, and closer to 2.4 for two-dimensional models. The effect of multiple, simultaneous walkers on the cost is also measured. For the one-dimensional Ising model the cost can increase with the number of walkers for large systems. For both the Ising and Heisenberg models in two-dimensions, no adverse impact on the cost is observed. Thus multiple walkers is a strategy that should scale well in a parallel computing environment for many models of magnetic materials.

  2. Improving Wang-Landau sampling with adaptive windows

    NASA Astrophysics Data System (ADS)

    Cunha-Netto, A. G.; Caparica, A. A.; Tsai, Shan-Ho; Dickman, Ronald; Landau, D. P.

    2008-11-01

    Wang-Landau sampling (WLS) of large systems requires dividing the energy range into “windows” and joining the results of simulations in each window. The resulting density of states (and associated thermodynamic functions) is shown to suffer from boundary effects in simulations of lattice polymers and the five-state Potts model. Here, we implement WLS using adaptive windows. Instead of defining fixed energy windows (or windows in the energy-magnetization plane for the Potts model), the boundary positions depend on the set of energy values on which the histogram is flat at a given stage of the simulation. Shifting the windows each time the modification factor f is reduced, we eliminate border effects that arise in simulations using fixed windows. Adaptive windows extend significantly the range of system sizes that may be studied reliably using WLS.

  3. The Receptor Binding Domain of Botulinum Neurotoxin Serotype A (BoNT/A) Inhibits BoNT/A and BoNT/E Intoxications In Vivo

    PubMed Central

    Ben David, Alon; Diamant, Eran; Barnea, Ada; Rosen, Osnat; Torgeman, Amram

    2013-01-01

    The receptor binding domain of botulinum neurotoxin (BoNT), also designated the C terminus of the heavy chain (HC), is a promising vaccine candidate against botulism. In this study, a highly efficient expression system for the protein was developed in Escherichia coli, which provided yields that were 1 order of magnitude higher than those reported to date (350 mg HC per liter). The product was highly immunogenic, protecting mice from a challenge with 105 50% lethal dose (LD50) after a single vaccination and generating a neutralizing titer of 49.98 IU/ml after three immunizations. In addition, a single boost with HC increased neutralizing titers by up to 1 order of magnitude in rabbits hyperimmunized against toxoid. Moreover, we demonstrate here for the first time in vivo inhibition of BoNT/A intoxication by HC/A, presumably due to a blockade of the neurotoxin protein receptor SV2. Administration of HC/A delayed the time to death from 10.4 to 27.3 h in mice exposed to a lethal dose of BoNT/A (P = 0.0005). Since BoNT/A and BoNT/E partially share SV2 isoforms as their protein receptors, the ability of HC/A to cross-inhibit BoNT/E intoxication was evaluated. The administration of HC/A together with BoNT/E led to 50% survival and significantly delayed the time to death for the nonsurviving mice (P = 0.003). Furthermore, a combination of HC/A and a subprotective dose of antitoxin E fully protected mice against 850 mouse LD50 of BoNT/E, suggesting complementary mechanisms of protection consisting of toxin neutralization by antibodies and receptor blocking by HC/A. PMID:23761665

  4. Low-energy BO and BO 2 emission from H 2BO 3 sputtered in a low-pressure high-frequency SNMS plasma

    NASA Astrophysics Data System (ADS)

    Jenett, Holger; Ai, Xingtao; Hodoroaba, Vasile-Dan; Iga, Ione; Mu Tao, Lee

    1999-07-01

    Background corrected secondary neutral energy spectra derived from Cu powder pellets with H 3BO 3, MgO, Al 2O 3, TiO 2, Y 2O 3 and ZrO 2, show energy distributions being more or less typical for collision cascades in the cases of the metal ions M +, of O + at energies >5 eV above the ion generation potential, and of the molecules Cu 2+, AlO +, TiO +, YO + and ZrO +, whereas the larger parts of the energy distributions of BO +and BO 2+exhibit a similar shape as the Ar +plasma gas ions. From this, and from the background of the low decomposition and melting temperatures of H 3BO 3 and B 2O 3, respectively, we conclude that the detected BO and BO 2 molecules have been emitted with thermal energies in processes implying lower energies than collision cascades. Evidence was found that the same holds for HBO 2 and H 2BO 2. In order to obtain relative correction factors for MO + molecular ion intensities, electron impact ionization cross sections have been calculated for the light MO molecules using the binary-encounter Bethe (BEB) formula, and for the respective metal M atoms by means of the semiempirical Lotz formula. For the heavy MO molecules YO and ZrO, cross sections have been estimated using the Thomson formula. The comparison of corrected relative MO/M and M/Cu intensities yields evidence that thermal (H)BO x emission amounts to the same order of magnitude as B emission from collision cascades, and that this situation is comparable to the high yield of MO molecules emitted in collision cascades from oxides with high M masses. Since the normal energy window of an HF-plasma secondary neutral mass spectrometer does not accept particles with originally thermal energies, it is concluded that these findings are relevant for quantification.

  5. Growth and characterization of acentric BaHf(BO3)2 and BaZr(BO3)2

    NASA Astrophysics Data System (ADS)

    Mączka, Mirosław; Szymborska-Małek, Katarzyna; Gągor, Anna; Majchrowski, Andrzej

    2015-05-01

    Growth, single crystal X-ray diffraction, polarized Raman and infrared (IR) studies of BaHf(BO3)2 are presented. Raman and IR spectra of polycrystalline BaZr(BO3)2 are also reported to facilitate assignment of modes. BaHf(BO3)2 borate crystallizes in trigonal system, space group R3c, with lattice parameters: a=5.1540(4) Å, c=33.901(3) Å. It accommodates dolomite-like structure doubled in the c direction, which is built of alternating layers of HfO6 octahedra and BaO6 distorted trigonal prisms that are connected through borate groups. The obtained structural as well as spectroscopic data show that BaHf(BO3)2 is isostructural with BaZr(BO3)2 and the deviations from centrosymmetry is small.

  6. The Structure of the Kac-Wang-Yan Algebra

    NASA Astrophysics Data System (ADS)

    Linshaw, Andrew R.

    2015-11-01

    The Lie algebra D of regular differential operators on the circle has a universal central extension {hat{D}} . The invariant subalgebra {hat{D}^+} under an involution preserving the principal gradation was introduced by Kac, Wang, and Yan. The vacuum {hat{D}^+} -module with central charge {c in C} , and its irreducible quotient {V}_c, possess vertex algebra structures, and {V}_c has a nontrivial structure if and only if c in 1/2 Z. We show that for each integer {n > 0} , V_{n/2} and V_{-n} are W -algebras of types W(2, 4,dots,2n) and W(2, 4,dots, 2n^2 + 4n), respectively. These results are formal consequences of Weyl's first and second fundamental theorems of invariant theory for the orthogonal group {O(n)} and the symplectic group {Sp(2n)} , respectively. Based on Sergeev's theorems on the invariant theory of {Osp(1, 2n)} we conjecture that V_{-n+1/2} is of type W(2, 4,dots, 4n^2 + 8n + 2), and we prove this for {n = 1} . As an application, we show that invariant subalgebras of {βγ} -systems and free fermion algebras under arbitrary reductive group actions are strongly finitely generated.

  7. [Mr. Wang Le-ting: a master of acupuncture].

    PubMed

    Niu, Xue-Song; Wang, Fan

    2012-11-01

    Mr. WANG Le-ting attaches great importance to accurate differentiation of syndromes, strict selection of acupoints, technique and direction of needle insertion, clear reinforcing and reducing methods after the appearance of needling sensations, proper opportunities of manipulations as well as needle withdrawal techniques, and reasonable application of acupuncture and moxibustion respectively. The above mentioned principles are known as his "5 agreements". He emphasizes that the selection of acupoints should be "in accordance with both the meridians and the accurate location of the points", and "needling sensation is necessary for each point". He holds that the back-shu points of the five-zang organs and Geshu (BL 17) can be adopted for patient with deficiency of qi, blood, yin and yang. In the aspect of acupoint theory, he insists the accurate location of Xuanzhong (GB 39). He also adjusts the locations of Huatuo Jiaji (EX-B 2) points, and finds the location of the new Dubi (ST 35). For easier applications, he divides the functions of acupoints into different schools of qi, blood, cold, heat, deficiency, excess, wind and dampness. And 41 combinations of acupoints are also invented as innovation. He is always strict to his students, instructing and influencing them by his own words and deeds. He is always conscientious and meticulous, which benefit immensely his followers, and remains a lot of precious experiences for the later generations. PMID:23214000

  8. The Structure of the Kac-Wang-Yan Algebra

    NASA Astrophysics Data System (ADS)

    Linshaw, Andrew R.

    2016-07-01

    The Lie algebra {mathcal{D}} of regular differential operators on the circle has a universal central extension {hat{mathcal{D}}}. The invariant subalgebra {hat{mathcal{D}}^+} under an involution preserving the principal gradation was introduced by Kac, Wang, and Yan. The vacuum {hat{mathcal{D}}^+}-module with central charge {c in mathbb{C}}, and its irreducible quotient {mathcal{V}_c}, possess vertex algebra structures, and {mathcal{V}_c} has a nontrivial structure if and only if {c in 1/2mathbb{Z}}. We show that for each integer {n > 0}, {mathcal{V}_{n/2}} and {mathcal{V}_{-n}} are {mathcal{W}}-algebras of types {mathcal{W}(2, 4,dots,2n)} and {mathcal{W}(2, 4,dots, 2n^2 + 4n)}, respectively. These results are formal consequences of Weyl's first and second fundamental theorems of invariant theory for the orthogonal group {O(n)} and the symplectic group {Sp(2n)}, respectively. Based on Sergeev's theorems on the invariant theory of {Osp(1, 2n)} we conjecture that {mathcal{V}_{-n+1/2}} is of type {mathcal{W}(2, 4,dots, 4n^2 + 8n + 2)}, and we prove this for {n = 1}. As an application, we show that invariant subalgebras of {βγ}-systems and free fermion algebras under arbitrary reductive group actions are strongly finitely generated.

  9. [Research on Wang Mengying's theory of nourishing - Yin and protecting - fluid].

    PubMed

    Feng, Chonglian

    2002-01-01

    As a famous physician of Zhejiang and Jiangsu in the late Qing dynasty, Wang Mengying was especially conversant with Wen Bing (Warm Disease). By reading Wang's works and his 16 - volume clinical case records now extant, it can be held that the clinical career of Wang was penetrated with the idea of nourishing - yin and protecting - fluid, which can be summarized into as. plain nourishing, reducing yang to nourish yin, activating Qi and distributing fluid, and protection prior to having been injured. PMID:12015060

  10. Structure of the BoNT/A1--receptor complex.

    PubMed

    Benoit, Roger M; Frey, Daniel; Wieser, Mara M; Thieltges, Katherine M; Jaussi, Rolf; Capitani, Guido; Kammerer, Richard A

    2015-12-01

    Botulinum neurotoxin A causes botulism but is also used for medical and cosmetic applications. A detailed molecular understanding of BoNT/A--host receptor interactions is therefore fundamental for improving current clinical applications and for developing new medical strategies targeting human disorders. Towards this end, we recently solved an X-ray crystal structure of BoNT/A1 in complex with its neuronal protein receptor SV2C. Based on our findings, we discuss the potential implications for BoNT/A function. PMID:26260692

  11. Generalizing Swendsen-Wang to sampling arbitrary posterior probabilities.

    PubMed

    Barbu, Adrian; Zhu, Song-Chun

    2005-08-01

    Many vision tasks can be formulated as graph partition problems that minimize energy functions. For such problems, the Gibbs sampler provides a general solution but is very slow, while other methods, such as Ncut and graph cuts are computationally effective but only work for specific energy forms and are not generally applicable. In this paper, we present a new inference algorithm that generalizes the Swendsen-Wang method to arbitrary probabilities defined on graph partitions. We begin by computing graph edge weights, based on local image features. Then, the algorithm iterates two steps. 1) Graph clustering: It forms connected components by cutting the edges probabilistically based on their weights. 2) Graph relabeling: It selects one connected component and flips probabilistically, the coloring of all vertices in the component simultaneously. Thus, it realizes the split, merge, and regrouping of a "chunk" of the graph, in contrast to Gibbs sampler that flips a single vertex. We prove that this algorithm simulates ergodic and reversible Markov chain jumps in the space of graph partitions and is applicable to arbitrary posterior probabilities or energy functions defined on graphs. We demonstrate the algorithm on two typical problems in computer vision--image segmentation and stereo vision. Experimentally, we show that it is 100-400 times faster in CPU time than the classical Gibbs sampler and 20-40 times faster then the DDMCMC segmentation algorithm. For stereo, we compare performance with graph cuts and belief propagation. We also show that our algorithm can automatically infer generative models and obtain satisfactory results (better than the graphic cuts or belief propagation) in the same amount of time. PMID:16119263

  12. Role of the BO bond in the reaction dynamics of BO+H 2→HBO+H

    NASA Astrophysics Data System (ADS)

    Sogas, J.; Albertí, M.; Giménez, X.; Aguilar, A.

    2001-10-01

    An extensive quasiclassical trajectory study of the dynamics of the title reaction has been carried out on a six-dimensional, analytical potential energy surface, with the goal of understanding the role of the BO bond. For this purpose, trajectories for different hypothetical isotopes of the BO molecule have been calculated, for selected rovibrational levels of the reactants, at low and moderate collision energies. For all these cases, a clear departure from the BO bond spectator behaviour, as well as an unexpected role of hindered rotation normal modes at the transition state, is found.

  13. A new paradigm for petascale Monte Carlo simulation: Replica exchange Wang Landau sampling

    SciTech Connect

    Li, Ying Wai; Vogel, Thomas; Wuest, Thomas; Landau, David P

    2014-01-01

    We introduce a generic, parallel Wang Landau method that is naturally suited to implementation on massively parallel, petaflop supercomputers. The approach introduces a replica-exchange framework in which densities of states for overlapping sub-windows in energy space are determined iteratively by traditional Wang Landau sampling. The advantages and general applicability of the method are demonstrated for several distinct systems that possess discrete or continuous degrees of freedom, including those with complex free energy landscapes and topological constraints.

  14. Biological activity of BO-1236, a new antipseudomonal cephalosporin.

    PubMed Central

    Nakagawa, S; Sanada, M; Matsuda, K; Hazumi, N; Tanaka, N

    1987-01-01

    BO-1236, a new cephalosporin having an N-methyl-5,6-dihydroxyisoindolinium moiety on the 3-methylene of the cephem, showed potent activity against gram-negative organisms, including Pseudomonas aeruginosa. The in vitro activity of BO-1236 was superior or comparable to that of ceftazidime, cefotaxime, and cefoperazone in susceptibility tests with clinical isolates. BO-1236 was significantly more active than ceftazidime against P. aeruginosa strains susceptible or resistant to ceftazidime or gentamicin or both. MBCs were usually close to MICs, both of which were influenced by inoculum size to about the same degree as those of the other beta-lactams. BO-1236 was stable to all types of beta-lactamases except type I oxyiminocephalosporin-hydrolyzing enzyme, by which BO-1236 was slightly hydrolyzed. BO-1236 showed protective activity superior to that of ceftazidime and cefotaxime in experimental infections in mice caused by two strains of P. aeruginosa and showed activity comparable to that of ceftazidime and cefotaxime against other gram-negative bacterial infections. PMID:3116919

  15. On the Prediction of Separation Bubbles Using a Modified Chen-Thyson Model

    NASA Technical Reports Server (NTRS)

    Platzer, Max F.; Ekaterinaris, John A.; Chandrasekhara, M. S.

    2007-01-01

    The prediction of separation bubbles on NACA 65-213 and NACA 0012 using a modified Chen-Thyson transition model is presented. The contents include: 1) Background; 2) Analysis of NACA 65-213 separation bubble using cebeci's viscous-inviscid interaction method; 3) Analysis of NACA 0012 separation bubble using navier-stokes method; and 4) Comparison with experiment.

  16. Level of chemical and microbiological contaminations in chili bo (paste).

    PubMed

    Zaini, Nurul Aqilah Mohd; Harith, Hanis Hazeera; Olusesan, Akanbi Taiwo; Zulkifli, Anwarul Hidayah; Bakar, Fatimah Abu; Osman, Azizah; Hamid, Azizah Abd; Saari, Nazamid

    2010-03-01

    The objective of this study was to determine the level of preservatives and microbiological loads in various brands of commercially available chili bo (paste). Fifteen different brands of chili bo obtained from the local market and hypermarkets were analyzed for pH, moisture and benzoic acid content, microbiological loads (aerobic, anaerobic, aerobic spores, and fungi), and thermophilic microorganisms. Results showed that both moisture content and pH vary among samples. The concentrations of benzoic acid detected in chili bo were found to be in the range of 537 to 5,435 mg/kg. Nine of fifteen brands were found to exceed the maximum level permitted by the Malaysian Food Law in accordance with the Codex Alimentarius (1,000 mg/kg for benzoic acid). An apparent correlation between benzoic acid concentration and microbiological loads present in the chili bo was observed. The microbiological loads were found to be relatively low in the end products containing high amounts of benzoic acid. The heat-resistant (70 to 80 degrees C) microorganisms present in chili bo were identified as Ochrobacterum tritici, Stenotrophomonas rhizophila, Microbacterium maritypicum, Roseomonas spp., CDC group II-E subgroup A, Flavimonas oryzihabitans, and Pseudomonas aeruginosa, with M. maritypicum being the most frequently found (in 9 of 15 samples) microorganism. Most of these identified microorganisms were not known to cause foodborne illnesses. PMID:20202342

  17. [Mr. Chen Ying-long of chengjiang acupuncture school: a brief introduction].

    PubMed

    Zhu, An-Ning; Zhang, Jian-Bin; Sun, Xiao-Zhong; Meng, Xian-Jun

    2012-11-01

    Through consultation of the historical literatures on Mr. CHEN Ying-long, investigating his teaching experiences in Xiamen Hospital of TCM and Xiamen University, the characteristics of his educational idea on acupuncture-moxibustion, are found as follows: great significance is found in the dissemination of Chengjiang acupuncture school in Minnan area of China and abroad through the combination of the succession of education from a masters to disciples and the classroom teaching; importance is attached to medical ethics, and priority is put on building up ethics and teaching by precept and example. In order to inherit the Chengjiang acupuncture school, Mr. CHEN focuses on fostering a proper studying method, emphasizes on the basic skills of acupuncture, reinforces clinical practice and techniques, edits books, and imparts knowledge and solves doubts. PMID:23214002

  18. A Class of Integer Order and Fractional Order Hyperchaotic Systems via the Chen System

    NASA Astrophysics Data System (ADS)

    Xu, Fei

    2016-06-01

    In this article, we investigate the generation of a class of hyperchaotic systems via the Chen chaotic system using both integer order and fractional order differential equation systems. Based on the Chen chaotic system, we designed a system with four nonlinear ordinary differential equations. For different parameter sets, the trajectory of the system may diverge or display a hyperchaotic attractor with double wings. By linearizing the ordinary differential equation system with divergent trajectory and designing proper switching controls, we obtain a chaotic attractor. Similar phenomenon has also been observed in linearizing the hyperchaotic system. The corresponding fractional order systems are also considered. Our investigation indicates that, switching control can be applied to either linearized chaotic or nonchaotic differential equation systems to create chaotic attractor.

  19. Detection of Bovine Herpesvirus 4 (BoHV-4) DNA in the Cell Fraction of Milk of Dairy Cattle with History of BoHV-4 Infection

    PubMed Central

    Donofrio, Gaetano; Flammini, Cesidio Filippo; Scatozza, Franco; Cavirani, Sandro

    2000-01-01

    We have demonstrated, by PCR and restriction enzyme analysis of the PCR product, the presence of bovine herpesvirus 4 (BoHV-4) DNA in the cell fraction of milk from dairy cattle with a history of BoHV-4 infection. We next evaluated the infectious nature of BoHV-4 DNA in those cells. Cocultivation of a BoHV-4-sensitive cell line with BoHV-4 DNA-positive milk cell samples produced cytopathic effects. The same result was obtained from frozen and thawed milk cell fraction coming from the cell milk fraction PCR-positive cows, ensuring that cells were killed and only infectious virus could be recovered after cocultivation with sensitive cells. This report shows that infectious BoHV-4 can be present in milk cells and that therefore nursing may be one of the transmission routes of BoHV-4. PMID:11101621

  20. The Evolving Magnetic Topology of τ Boötis

    NASA Astrophysics Data System (ADS)

    Fares, M. W. Mengel R.; Marsden, S. C.; Carter, B. D.; Jeffers, S. V.; Petit, P.; Donati, J.-F.; Folsom, C. P.; BCool Collaboration

    2016-04-01

    We present six epochs of spectropolarimetric observations of the hot-Jupiter-hosting star τ Boötis that extend the exceptional previous multi-year data set of its large-scale magnetic field. Our results confirm that the large-scale magnetic field of τ Boötis varies cyclicly, with the observation of two further magnetic reversals; between December 2013 and May 2014 and between January and March 2015. We also show that the field evolves in a broadly solar-type manner in contrast to other F-type stars. We further present new results which indicate that the chromospheric activity cycle and the magnetic activity cycles are related, which would indicate a very rapid magnetic cycle. As an exemplar of long-term magnetic field evolution, τ Boötis and this long-term monitoring campaign presents a unique opportunity for studying stellar magnetic cycles.

  1. The evolving magnetic topology of τ Boötis

    NASA Astrophysics Data System (ADS)

    Mengel, M. W.; Fares, R.; Marsden, S. C.; Carter, B. D.; Jeffers, S. V.; Petit, P.; Donati, J.-F.; Folsom, C. P.; the BCool Collaboration

    2016-07-01

    We present six epochs of spectropolarimetric observations of the hot-Jupiter-hosting star τ Boötis that extend the exceptional previous multiyear data set of its large-scale magnetic field. Our results confirm that the large-scale magnetic field of τ Boötis varies cyclicly, with the observation of two further magnetic reversals; between 2013 December and 2014 May and between 2015 January and March. We also show that the field evolves in a broadly solar-type manner in contrast to other F-type stars. We further present new results which indicate that the chromospheric activity cycle and the magnetic activity cycles are related, which would indicate a very rapid magnetic cycle. As an exemplar of long-term magnetic field evolution, τ Boötis and this long-term monitoring campaign presents a unique opportunity for studying stellar magnetic cycles.

  2. Replica-exchange Wang Landau sampling: pushing the limits of Monte Carlo simulations in materials sciences

    SciTech Connect

    Perera, Meewanage Dilina N; Li, Ying Wai; Eisenbach, Markus; Vogel, Thomas; Landau, David P

    2015-01-01

    We describe the study of thermodynamics of materials using replica-exchange Wang Landau (REWL) sampling, a generic framework for massively parallel implementations of the Wang Landau Monte Carlo method. To evaluate the performance and scalability of the method, we investigate the magnetic phase transition in body-centered cubic (bcc) iron using the classical Heisenberg model parameterized with first principles calculations. We demonstrate that our framework leads to a significant speedup without compromising the accuracy and precision and facilitates the study of much larger systems than is possible with its serial counterpart.

  3. Temperature dependent luminescence characteristics of KBe2BO3F2 and RbBe2BO3F2

    NASA Astrophysics Data System (ADS)

    Martincik, J.; Babin, V.; Liu, L.; Wang, X.; Chen, C. T.; Beitlerova, A.; Mihokova, E.; Nikl, M.

    2015-04-01

    This paper reports on a study of the luminescence characteristics of KBe2BO3F2 (KBBF) and RbBe2BO3F2(RBBF) crystals in UV/visible spectral range. The KBBF crystals are very popular for their nonlinear optical properties, however they have a potential to be used as scintillators for neutron detection. To determine the effectiveness of KBBF scintillation we combine the results from measurements of optical absorption; radioluminescence; light yield; photoluminescence and decay kinetics in the temperature range 8-330 K. Temperature dependence of luminescence in KBBF crystals is discussed.

  4. Time budgets of Snow Geese Chen caerulescens and Ross's Geese Chen rossii in mixed flocks: Implications of body size, ambient temperature and family associations

    USGS Publications Warehouse

    Jonsson, J.E.; Afton, A.D.

    2009-01-01

    Body size affects foraging and forage intake rates directly via energetic processes and indirectly through interactions with social status and social behaviour. Ambient temperature has a relatively greater effect on the energetics of smaller species, which also generally are more vulnerable to predator attacks than are larger species. We examined variability in an index of intake rates and an index of alertness in Lesser Snow Geese Chen caerulescens caerulescens and Ross's Geese Chen rossii wintering in southwest Louisiana. Specifically we examined variation in these response variables that could be attributed to species, age, family size and ambient temperature. We hypothesized that the smaller Ross's Geese would spend relatively more time feeding, exhibit relatively higher peck rates, spend more time alert or raise their heads up from feeding more frequently, and would respond to declining temperatures by increasing their proportion of time spent feeding. As predicted, we found that Ross's Geese spent more time feeding than did Snow Geese and had slightly higher peck rates than Snow Geese in one of two winters. Ross's Geese spent more time alert than did Snow Geese in one winter, but alert rates differed by family size, independent of species, in contrast to our prediction. In one winter, time spent foraging and walking was inversely related to average daily temperature, but both varied independently of species. Effects of age and family size on time budgets were generally independent of species and in accordance with previous studies. We conclude that body size is a key variable influencing time spent feeding in Ross's Geese, which may require a high time spent feeding at the expense of other activities. ?? 2008 The Authors.

  5. Growth and characterization of acentric BaHf(BO{sub 3}){sub 2} and BaZr(BO{sub 3}){sub 2}

    SciTech Connect

    Mączka, Mirosław; Szymborska-Małek, Katarzyna; Gągor, Anna; Majchrowski, Andrzej

    2015-05-15

    Growth, single crystal X-ray diffraction, polarized Raman and infrared (IR) studies of BaHf(BO{sub 3}){sub 2} are presented. Raman and IR spectra of polycrystalline BaZr(BO{sub 3}){sub 2} are also reported to facilitate assignment of modes. BaHf(BO{sub 3}){sub 2} borate crystallizes in trigonal system, space group R3c, with lattice parameters: a=5.1540(4) Å, c=33.901(3) Å. It accommodates dolomite-like structure doubled in the c direction, which is built of alternating layers of HfO{sub 6} octahedra and BaO{sub 6} distorted trigonal prisms that are connected through borate groups. The obtained structural as well as spectroscopic data show that BaHf(BO{sub 3}){sub 2} is isostructural with BaZr(BO{sub 3}){sub 2} and the deviations from centrosymmetry is small. - Graphical abstract: Arrangement of BO{sub 3} groups in BaHf(BO{sub 3}){sub 2} along the c direction in one unit cell. Dark and light blue denote different borate groups. - Highlights: • BaHf(BO{sub 3}){sub 2} single crystals were grown. • X-ray diffraction showed that this borate crystallizes in the acentric R3c structure. • Raman and IR spectra were measured for BaHf(BO{sub 3}){sub 2} and BaZr(BO{sub 3}){sub 2}, respectively. • Assignment of modes is proposed.

  6. Role of bovine herpesvirus type 5 (BoHV-5) in diseases of cattle. Recent findings on BoHV-5 association with genital disease

    PubMed Central

    Favier, P.A.; Marin, M.S.; Pérez, S.E.

    2012-01-01

    Bovine herpesvirus type 5 (BoHV-5) belongs to the family Herpesviridae, subfamily Alphaherpesvirinae, genus Varicellovirus. This virus is a major causative agent of non-suppurative meningoencephalitis in young cattle. It was first isolated in 1962 from a neurological disease outbreak in Australia. BoHV-5 is genetically and antigenically related to bovine herpesvirus type 1 (BoHV-1), a highly prevalent virus responsible for respiratory and genital disease in cattle. Initially, BoHV-5 was considered a subtype of BoHV-1 (BoHV-1.3). However, the exclusive presentation of outbreaks of neurological disease suggested that the virus was a new agent with characteristics of neuropathogenicity. Even though both are neurotropic viruses, only BoHV-5 is capable of replicating extensively in the central nervous system and inducing neurological disease. Occasionally, encephalitis caused by BoHV-1 has been reported. Like other alpha-herpesviruses, BoHV-5 can establish latency in nervous ganglia and, by stress factors or glucocorticoid treatment, latent virus can be reactivated. During episodes of reactivation, the virus is excreted in nasal, ocular and genital secretions and transmitted to other susceptible hosts. Recently, BoHV-5 has been associated with infection of the reproductive tract. The virus has been isolated and the presence of viral DNA has been demonstrated in semen samples from Brazil and Australia and natural transmission of the virus through contaminated semen has also been described. Embryos and oocytes are permissive for BoHV-5 infection and BoHV-5 DNA has been detected in the central nervous system of aborted fetuses. The objective of this review is to compile the limited information on the recent association between BoHV-5 and reproductive disorders in cattle. PMID:26623291

  7. AmeriFlux US-Bo1 Bondville

    SciTech Connect

    Meyers, Tilden

    2016-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-Bo1 Bondville. Site Description - Agriculture, continuous no-till since 1986, Annual rotation between corn (C4) and soybeans (C3). The field was planted with corn during 2005 and 2007, with soybeans during 2006 and 2008.

  8. AmeriFlux US-Bo2 Bondville (companion site)

    SciTech Connect

    Bernacchi, Carl

    2016-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-Bo2 Bondville (companion site). Site Description - Located 400m north of Tilden Meyer's site and planted with opposite crop in corn/soybean rotation

  9. FIRST Robotics, Gulfport High, StenniSphere, Bo Clarke, mentor

    NASA Technical Reports Server (NTRS)

    2006-01-01

    Bo Clarke, mentor for Gulfport High School's Team Fusion, offers strategy tips to students and coaches during the FIRST Robotics Competition kickoff held at StenniSphere on Jan. 7. Clarke is the lead building and infrastructure specialist for NASA's Shared Services Center at Stennis Space Center.

  10. Reemergence of chikungunya virus in Bo, Sierra Leone.

    PubMed

    Ansumana, Rashid; Jacobsen, Kathryn H; Leski, Tomasz A; Covington, Andrea L; Bangura, Umaru; Hodges, Mary H; Lin, Baochuan; Bockarie, Alfred S; Lamin, Joseph M; Bockarie, Moses J; Stenger, David A

    2013-07-01

    We diagnosed 400 possible IgM-positive cases of chikungunya virus in Bo, Sierra Leone, during July 2012-January 2013 by using lateral flow immunoassays. Cases detected likely represent only a small fraction of total cases. Further laboratory testing is required to confirm this outbreak and characterize the virus. PMID:23764023

  11. Fetal Intrahepatic Cholestasis Secondary to BO Hemolytic Disease

    PubMed Central

    Raju, T. N. K.; Javed, Durr-I-Shahwar

    1981-01-01

    A rare occurrence of severe, direct hyperbilirubinemia in an infant with BO incompatibility was noted at four hours of age. Severe fetal hemolysis and markedly elevated indirect bilirubin levels might have caused induction of conjugating enzymes during fetal life in this case. Intrahepatic cholestasis was responsible for persistent conjugated hyperbilirubinemia after birth. This responded favorably to cholestyramine therapy. PMID:7196459

  12. Reemergence of Chikungunya Virus in Bo, Sierra Leone

    PubMed Central

    Ansumana, Rashid; Leski, Tomasz A.; Covington, Andrea L.; Bangura, Umaru; Hodges, Mary H.; Lin, Baochuan; Bockarie, Alfred S.; Lamin, Joseph M.; Bockarie, Moses J.; Stenger, David A.

    2013-01-01

    We diagnosed 400 possible IgM-positive cases of chikungunya virus in Bo, Sierra Leone, during July 2012–January 2013 by using lateral flow immunoassays. Cases detected likely represent only a small fraction of total cases. Further laboratory testing is required to confirm this outbreak and characterize the virus. PMID:23764023

  13. 40 CFR 721.3032 - Boric acid (H3BO2), zinc salt.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Boric acid (H3BO2), zinc salt. 721... Substances § 721.3032 Boric acid (H3BO2), zinc salt. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as boric acid (H3BO2), zinc salt (PMN...

  14. 40 CFR 721.3032 - Boric acid (H3BO2), zinc salt.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Boric acid (H3BO2), zinc salt. 721... Substances § 721.3032 Boric acid (H3BO2), zinc salt. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as boric acid (H3BO2), zinc salt (PMN...

  15. 40 CFR 721.3032 - Boric acid (H3BO2), zinc salt.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Boric acid (H3BO2), zinc salt. 721... Substances § 721.3032 Boric acid (H3BO2), zinc salt. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as boric acid (H3BO2), zinc salt (PMN...

  16. 40 CFR 721.3032 - Boric acid (H3BO2), zinc salt.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Boric acid (H3BO2), zinc salt. 721... Substances § 721.3032 Boric acid (H3BO2), zinc salt. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as boric acid (H3BO2), zinc salt (PMN...

  17. 40 CFR 721.3032 - Boric acid (H3BO2), zinc salt.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Boric acid (H3BO2), zinc salt. 721... Substances § 721.3032 Boric acid (H3BO2), zinc salt. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as boric acid (H3BO2), zinc salt (PMN...

  18. Bridge No. 1396, Fourth Potomac and Second B&O Crossing, with ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bridge No. 1396, Fourth Potomac and Second B&O Crossing, with B&O Potomac Crossing (built ca. 1914 as part of B&O's Magnolia Cutoff) in background, looking east. - Western Maryland Railway, Cumberland Extension, Pearre to North Branch, from WM milepost 125 to 160, Pearre, Washington County, MD

  19. Blaschke's rolling ball theorem and the Trudinger-Wang monotone bending

    NASA Astrophysics Data System (ADS)

    Karakhanyan, Aram L.

    2016-04-01

    We revisit the classical rolling ball theorem of Blaschke for convex surfaces with positive curvature and show that it is linked to another inclusion principle in the optimal mass transportation theory due to Trudinger and Wang. We also discuss an application to reflector antennae design problem.

  20. Commentary: A Closer Look at Task Analysis--Reactions to Wang, Schnipke, and Witt

    ERIC Educational Resources Information Center

    LaDuca, Tony

    2006-01-01

    In the Spring 2005 issue, Wang, Schnipke, and Witt provided an informative description of the task inventory approach that centered on four functions of job analysis. The discussion included persuasive arguments for making systematic connections between tasks and KSAs. But several other facets of the discussion were much less persuasive. This…

  1. An L1-Script-Transfer-Effect Fallacy: A Rejoinder to Wang et al

    ERIC Educational Resources Information Center

    Yamada, Jun

    2004-01-01

    Do different L1 (first language) writing systems differentially affect word identification in English as a second language (ESL)? Wang, Koda, and Perfetti [Cognition 87 (2003) 129] answered yes by examining Chinese students with a logographic L1 background and Korean students with an alphabetic L1 background for their phonological and orthographic…

  2. Additional symbols used in double-spaced text for Wang OIS word-processor users

    SciTech Connect

    Miller, J.A.

    1983-06-01

    This paper illustrates samples of Greek symbols (and other symbols) that are on the Wang daisy printwheel but not in the form that is often required. This technique can be used in place of rub-ons. It applies to double-spaced formats only, and involves creating new format lines within the text.

  3. Chen's derivative rule revisited: Role of tip-orbital interference in STM

    NASA Astrophysics Data System (ADS)

    Mándi, Gábor; Palotás, Krisztián

    2015-04-01

    On the occasion of its 25th anniversary, we revise Chen's derivative rule for electron tunneling [C. J. Chen, Phys. Rev. B 42, 8841 (1990), 10.1103/PhysRevB.42.8841] for the purpose of computationally efficient simulations of scanning tunneling microscopy (STM) based on first-principles electronic structure data. The revised model allows the weighting of tunneling matrix elements of different tip-orbital characters by an arbitrary energy-independent choice or based on energy-dependent weighting coefficients obtained by an expansion of the tip single-electron wave functions/density of states projected onto the tip-apex atom. Tip-orbital interference in the STM junction is included in the model by construction and can be analyzed quantitatively. As a further advantage, arbitrary tip geometrical orientations are included in the revised model by rotating the coordinate system of the tip apex using Euler angles and redefining the weighting coefficients of the tunneling matrix elements. We demonstrate the reliability of the model by applying it to two functionalized surfaces of recent interest where quantum interference effects play an important role in the STM imaging process: N-doped graphene and a magnetic Mn2H complex on the Ag(111) surface. We find that the proposed tunneling model is 25 times faster than the Bardeen method concerning computational time, while maintaining good agreement. Our results show that the electronic structure of the tip has a considerable effect on STM images, and the Tersoff-Hamann model does not always provide sufficient results in view of quantum interference effects. For both studied surfaces, we highlight the importance of interference between s and pz tip orbitals that can cause a significant contrast change in the STM images. Our method, thus, provides a fast and reliable tool for calculating STM images based on Chen's derivative rule, taking into account the electronic structure and local geometry of the tip apex.

  4. Chen Jingrun, China's famous mathematician: devastated by brain injuries on the doorstep to solving a fundamental mathematical puzzle.

    PubMed

    Lei, Ting; Belykh, Evgenii; Dru, Alexander B; Yagmurlu, Kaan; Elhadi, Ali M; Nakaji, Peter; Preul, Mark C

    2016-07-01

    Chen Jingrun (1933-1996), perhaps the most prodigious mathematician of his time, focused on the field of analytical number theory. His work on Waring's problem, Legendre's conjecture, and Goldbach's conjecture led to progress in analytical number theory in the form of "Chen's Theorem," which he published in 1966 and 1973. His early life was ravaged by the Second Sino-Japanese War and the Chinese Cultural Revolution. On the verge of solving Goldbach's conjecture in 1984, Chen was struck by a bicyclist while also bicycling and suffered severe brain trauma. During his hospitalization, he was also found to have Parkinson's disease. Chen suffered another serious brain concussion after a fall only a few months after recovering from the bicycle crash. With significant deficits, he remained hospitalized for several years without making progress while receiving modern Western medical therapies. In 1988 traditional Chinese medicine experts were called in to assist with his treatment. After a year of acupuncture and oxygen therapy, Chen could control his basic bowel and bladder functions, he could walk slowly, and his swallowing and speech improved. When Chen was unable to produce complex work or finish his final work on Goldbach's conjecture, his mathematical pursuits were taken up vigorously by his dedicated students. He was able to publish Youth Math, a mathematics book that became an inspiration in Chinese education. Although he died in 1996 at the age of 63 after surviving brutal political repression, being deprived of neurological function at the very peak of his genius, and having to be supported by his wife, Chen ironically became a symbol of dedication, perseverance, and motivation to his students and associates, to Chinese youth, to a nation, and to mathematicians and scientists worldwide. PMID:27364253

  5. The light subunit of system bo,+ is fully functional in the absence of the heavy subunit

    PubMed Central

    Reig, Núria; Chillarón, Josep; Bartoccioni, Paola; Fernández, Esperanza; Bendahan, Annie; Zorzano, Antonio; Kanner, Baruch; Palacín, Manuel; Bertran, Joan

    2002-01-01

    The heteromeric amino acid transporters are composed of a type II glycoprotein and a non-glycosylated polytopic membrane protein. System bo,+ exchanges dibasic for neutral amino acids. It is composed of rBAT and bo,+AT, the latter being the polytopic membrane subunit. Mutations in either of them cause malfunction of the system, leading to cystinuria. bo,+AT-reconstituted systems from HeLa or MDCK cells catalysed transport of arginine that was totally dependent on the presence of one of the bo,+ substrates inside the liposomes. rBAT was essential for the cell surface expression of bo,+AT, but it was not required for reconstituted bo,+AT transport activity. No system bo,+ transport was detected in liposomes derived from cells expressing rBAT alone. The reconstituted bo,+AT showed kinetic asymmetry. Expressing the cystinuria-specific mutant A354T of bo,+AT in HeLa cells together with rBAT resulted in defective arginine uptake in whole cells, which was paralleled by the reconstituted bo,+AT activity. Thus, subunit bo,+AT by itself is sufficient to catalyse transmembrane amino acid exchange. The polytopic subunits may also be the catalytic part in other heteromeric transporters. PMID:12234930

  6. The brightest of reionizing galaxies (BoRG) survey

    NASA Astrophysics Data System (ADS)

    Trenti, Michele

    2012-09-01

    Until now, investigating the early stages of galaxy formation has been primarily the realm of theoretical modeling and computer simulations, which require many physical ingredients and are challenging to test observationally. However, the latest Hubble Space Telescope observations in the near infrared are shedding new light on the properties of galaxies within the first billion years after the Big Bang, including our recent discovery of the most distant proto-cluster of galaxies at redshift z ~ 8. Here, I compare predictions from models of primordial and metal-enriched star formation during the dark ages with the latest Hubble observations of galaxies during the epoch of reionization. I focus in particular on the luminosity function and on galaxy clustering as measured from our Hubble Space Telescope Brightest of Reionizing Galaxies (BoRG) survey. BoRG has the largest area coverage to find luminous and rare z ~ 8 sources that are among the first galaxies to have formed in the Universe.

  7. The BoNuS Experiment At Jefferson Lab

    SciTech Connect

    Stephen Baltmann

    2005-02-01

    The BoNuS experiment at Jefferson Lab's Hall B is going to measure the structure of the quasi-free neutron via electron scattering off a deuteron target and detection of the slowly recoiling spectator proton at very backward angles. To detect the low momentum backward recoiling protons, the CLAS detector will be augmented with a novel radial time projection chamber featuring gas electron multipliers. Data taking is anticipated for 2005 or 2006.

  8. Water quality associated public health risk in Bo, Sierra Leone.

    PubMed

    Jimmy, David H; Sundufu, Abu J; Malanoski, Anthony P; Jacobsen, Kathryn H; Ansumana, Rashid; Leski, Tomasz A; Bangura, Umaru; Bockarie, Alfred S; Tejan, Edries; Lin, Baochuan; Stenger, David A

    2013-01-01

    Human health depends on reliable access to safe drinking water, but in many developing countries only a limited number of wells and boreholes are available. Many of these water resources are contaminated with biological or chemical pollutants. The goal of this study was to examine water access and quality in urban Bo, Sierra Leone. A health census and community mapping project in one neighborhood in Bo identified the 36 water sources used by the community. A water sample was taken from each water source and tested for a variety of microbiological and physicochemical substances. Only 38.9% of the water sources met World Health Organization (WHO) microbial safety requirements based on fecal coliform levels. Physiochemical analysis indicated that the majority (91.7%) of the water sources met the requirements set by the WHO. In combination, 25% of these water resources met safe drinking water criteria. No variables associated with wells were statistically significant predictors of contamination. This study indicated that fecal contamination is the greatest health risk associated with drinking water. There is a need to raise hygiene awareness and implement inexpensive methods to reduce fecal contamination and improve drinking water safety in Bo, Sierra Leone. PMID:22350346

  9. Wang OIS glossary package for reformatting documents telecommunicated to the OIS system

    SciTech Connect

    Markow, S.R.

    1983-12-09

    Documents that are composed on a computer and then transmitted by telecommunications into a Wang Office Information System (OIS) word processing system need to be reformatted and cleaned up before they can be used properly as word processing documents suitable for further revisions or additions. This report describes a group of glossary entries created for the Wang OIS which simplifies the job of cleaning up telecommunicated documents. This glossary is a semi-automated process designed to eliminate most of the tedious work needed to be performed in removing extra spaces and returns, adjusting formats, moving material, repagination, using tabs or indents, and similar problems. The report briefly discusses the problems, describes the glossary approach to solving them, and gives instructions for actually using the glossary entries.

  10. Two alternate proofs of Wang's lune formula for sparse distributed memory and an integral approximation

    NASA Technical Reports Server (NTRS)

    Jaeckel, Louis A.

    1988-01-01

    In Kanerva's Sparse Distributed Memory, writing to and reading from the memory are done in relation to spheres in an n-dimensional binary vector space. Thus it is important to know how many points are in the intersection of two spheres in this space. Two proofs are given of Wang's formula for spheres of unequal radii, and an integral approximation for the intersection in this case.

  11. Wang-Landau sampling in face-centered-cubic hydrophobic-hydrophilic lattice model proteins

    NASA Astrophysics Data System (ADS)

    Liu, Jingfa; Song, Beibei; Yao, Yonglei; Xue, Yu; Liu, Wenjie; Liu, Zhaoxia

    2014-10-01

    Finding the global minimum-energy structure is one of the main problems of protein structure prediction. The face-centered-cubic (fcc) hydrophobic-hydrophilic (HP) lattice model can reach high approximation ratios of real protein structures, so the fcc lattice model is a good choice to predict the protein structures. The lacking of an effective global optimization method is the key obstacle in solving this problem. The Wang-Landau sampling method is especially useful for complex systems with a rough energy landscape and has been successfully applied to solving many optimization problems. We apply the improved Wang-Landau (IWL) sampling method, which incorporates the generation of an initial conformation based on the greedy strategy and the neighborhood strategy based on pull moves into the Wang-Landau sampling method to predict the protein structures on the fcc HP lattice model. Unlike conventional Monte Carlo simulations that generate a probability distribution at a given temperature, the Wang-Landau sampling method can estimate the density of states accurately via a random walk, which produces a flat histogram in energy space. We test 12 general benchmark instances on both two-dimensional and three-dimensional (3D) fcc HP lattice models. The lowest energies by the IWL sampling method are as good as or better than those of other methods in the literature for all instances. We then test five sets of larger-scale instances, denoted by the S, R, F90, F180, and CASP target instances on the 3D fcc HP lattice model. The numerical results show that our algorithm performs better than the other five methods in the literature on both the lowest energies and the average lowest energies in all runs. The IWL sampling method turns out to be a powerful tool to study the structure prediction of the fcc HP lattice model proteins.

  12. Exploring new frontiers in statistical physics with a new, parallel Wang-Landau framework

    SciTech Connect

    Vogel, Thomas; Li, Ying Wai; Wuest, Thomas; Landau, David P

    2014-01-01

    Combining traditional Wang Landau sampling for multiple replica systems with an exchange of densities of states between replicas we describe a general framework for simulations on massively parallel Petaflop supercomputers. The advantages and general applicability of the method for simulations of complex systems are demonstrated for the classical 2D Potts spin model featuring a strong first-order transition and the self-assembly of lipid bilayers in amphiphilic solutions in a continuous model.

  13. Minke whale (Balaenoptera acutorostrata) boings detected at the Station ALOHA Cabled Observatory.

    PubMed

    Oswald, Julie N; Au, Whitlow W L; Duennebier, Fred

    2011-05-01

    Minke whales (Balaenoptera acutorostrata) in the tropical North Pacific are elusive and difficult to detect visually. The recent association of a unique sound called the "boing" to North Pacific minke whales has made it possible to use passive acoustics to investigate the occurrence of this species in Hawaiian waters. One year of recordings (17 February 2007-18 February 2008) made at the Station ALOHA Cabled Observatory were examined to investigate the characteristics of boings and temporal patterns in their occurrence at this site, located 100 km north of Oahu. Characteristics of boings exhibited low variability. Pulse repetition rate and duration measurements matched those for "central" or "Hawaii" boing types. Boings were detected from October until May, with a peak in March. Although no boings were detected from June to September, the absence of boings does not necessarily indicate the absence of minke whales. Significant diel variation in boing rate was not observed. The absence of a diel pattern in boing production suggests that day- or night-time acoustic surveys are equally acceptable methods for studying minke whale occurrence. Future research should include efforts to determine what other sounds are produced by minke whales in this area, and which age/sex classes produce boings. PMID:21568435

  14. Exploring Replica-Exchange Wang-Landau sampling in higher-dimensional parameter space

    SciTech Connect

    Valentim, Alexandra; Rocha, Julio C. S.; Tsai, Shan-Ho; Li, Ying Wai; Eisenbach, Markus; Fiore, Carlos E; Landau, David P

    2015-01-01

    We considered a higher-dimensional extension for the replica-exchange Wang-Landau algorithm to perform a random walk in the energy and magnetization space of the two-dimensional Ising model. This hybrid scheme combines the advantages of Wang-Landau and Replica-Exchange algorithms, and the one-dimensional version of this approach has been shown to be very efficient and to scale well, up to several thousands of computing cores. This approach allows us to split the parameter space of the system to be simulated into several pieces and still perform a random walk over the entire parameter range, ensuring the ergodicity of the simulation. Previous work, in which a similar scheme of parallel simulation was implemented without using replica exchange and with a different way to combine the result from the pieces, led to discontinuities in the final density of states over the entire range of parameters. From our simulations, it appears that the replica-exchange Wang-Landau algorithm is able to overcome this diculty, allowing exploration of higher parameter phase space by keeping track of the joint density of states.

  15. Cyan-emitting LiBaBO3:Eu2+ phosphor: Crystal structure and luminescence property comparison with LiSrBO3:Eu2+

    NASA Astrophysics Data System (ADS)

    Huang, Zhaohui; Ji, Haipeng; Fang, Minghao; Molokeev, Maxim S.; Liu, Shuyue; Liu, Yan'gai; Wu, Xiaowen

    2015-05-01

    Cyan-emitting LiBaBO3:Eu2+ phosphor was synthesized by solid-state reaction at 800 °C. Structure refinement by Rietveld method reveals that LiBaBO3 crystallizes in a monoclinic cell, space groups P21/c or P21/n. Upon 365 nm excitation, LiBaBO3:Eu2+ shows a symmetric emission band peaking at 496 nm with full-width at half-maximum of 80 nm; when monitoring at 496 nm, a broad excitation band in the UV region (250-420 nm) is observed. The luminescence property of LiBaBO3:Eu2+ is considerably different from LiSrBO3:Eu2+ which holds the same space group. The local structures of the two hosts are compared to explain the different behaviors of Eu2+.

  16. Isolation and quantification of botulinum neurotoxin from complex matrices using the BoTest matrix assays.

    PubMed

    Dunning, F Mark; Piazza, Timothy M; Zeytin, Füsûn N; Tucker, Ward C

    2014-01-01

    Accurate detection and quantification of botulinum neurotoxin (BoNT) in complex matrices is required for pharmaceutical, environmental, and food sample testing. Rapid BoNT testing of foodstuffs is needed during outbreak forensics, patient diagnosis, and food safety testing while accurate potency testing is required for BoNT-based drug product manufacturing and patient safety. The widely used mouse bioassay for BoNT testing is highly sensitive but lacks the precision and throughput needed for rapid and routine BoNT testing. Furthermore, the bioassay's use of animals has resulted in calls by drug product regulatory authorities and animal-rights proponents in the US and abroad to replace the mouse bioassay for BoNT testing. Several in vitro replacement assays have been developed that work well with purified BoNT in simple buffers, but most have not been shown to be applicable to testing in highly complex matrices. Here, a protocol for the detection of BoNT in complex matrices using the BoTest Matrix assays is presented. The assay consists of three parts: The first part involves preparation of the samples for testing, the second part is an immunoprecipitation step using anti-BoNT antibody-coated paramagnetic beads to purify BoNT from the matrix, and the third part quantifies the isolated BoNT's proteolytic activity using a fluorogenic reporter. The protocol is written for high throughput testing in 96-well plates using both liquid and solid matrices and requires about 2 hr of manual preparation with total assay times of 4-26 hr depending on the sample type, toxin load, and desired sensitivity. Data are presented for BoNT/A testing with phosphate-buffered saline, a drug product, culture supernatant, 2% milk, and fresh tomatoes and includes discussion of critical parameters for assay success. PMID:24638074

  17. Forcing term in single-phase and Shan-Chen-type multiphase lattice Boltzmann models.

    PubMed

    Huang, Haibo; Krafczyk, Manfred; Lu, Xiyun

    2011-10-01

    Numerous schemes have been proposed to incorporate a bulk forcing term into the lattice Boltzmann equation. In this paper we present a simple and straightforward comparative analysis of five popular schemes [Shan and Chen, Phys. Rev. E 47, 1815 (1993); Phys Rev Lett. 81, 1618 (1998); He et al., Phys. Rev. E 57, R13 (1998); Guo et al., Phys. Rev. E 65, 046308 (2002); Kupershtokh et al., Comput. Math. Appl. 58, 965 (2009)] in which their differences and similarities are identified. From the analysis we classify the schemes into two groups; the behaviors of the schemes in each group are proven to be identical up to second order. Numerical test simulating the two-dimensional unsteady Taylor-Green vortex flow problem demonstrate that all five schemes are of comparable accuracy for single-phase flow. However, for two-phase flow the situation is different, which is demonstrated by incorporating these schemes into different Shan-Chen-type multiphase models. The forcing scheme in the original Shan-Chen (SC) multiphase model turns out to be inaccurate in terms of the resulting surface tension for different density ratios and relaxation times. In the numerical tests, a typical equation of state and interparticle interactions including next-nearest neighbors were incorporated into the SC model. Our results confirm that the surface-tension values obtained from the original SC lattice Boltzmann method (LBM) simulation depend on the value of the relaxation time τ. For τ<0.7Δt, the surface tension agree well with the analytical solutions. However, when τ>0.7Δt, the surface tension turns out to be systematically larger than the analytical one, exceeding it by more than a factor of 2 for τ=2Δt. In contrast, with the application of the scheme proposed by He et al., the SC LBM produces very accurate surface tensions independent of the value of τ. We also found that the densities of the coexisting liquid and gas can be adjusted to match those at thermodynamic equilibrium if the

  18. Review of the genus Canalirogas van Achterberg & Chen (Hymenoptera, Braconidae, Rogadinae) from Vietnam, with description of ten new species

    PubMed Central

    Long, Khuat Dang; van Achterberg, Cornelis

    2015-01-01

    Abstract The Vietnamese species of the genus Canalirogas van Achterberg & Chen, 1996 (Hymenoptera: Braconidae: Rogadinae) are revised. Ten species are new to science, viz., Canalirogas affinis sp. n., Canalirogas cucphuongensis sp. n., Canalirogas curvinervis sp. n., Canalirogas eurycerus sp. n., Canalirogas hoabinhicus sp. n., Canalirogas intermedius sp. n., Canalirogas parallelus sp. n., Canalirogas robberti sp. n., Canalirogas vittatus sp. n. and Canalirogas vuquangensis sp. n. One species is new for the Vietnamese fauna: Canalirogas spilonotus (Cameron, 1905) and Canalirogas balgooyi van Achterberg & Chen, 1996, is synonymized with it (syn. n.); a lectotype is designated for Troporhogas spilonotus. A key to the Vietnamese species of the genus is also provided. PMID:26085793

  19. VizieR Online Data Catalog: Spitzer/IRS debris disk catalog. I. (Chen+, 2014)

    NASA Astrophysics Data System (ADS)

    Chen, C. H.; Mittal, T.; Kuchner, M.; Forrest, W. J.; Lisse, C. M.; Manoj, P.; Sargent, B. A.; Watson, D. M.

    2014-05-01

    In Chen et al. (2006ApJS..166..351C), we obtained IRS spectra of 59 main-sequence stars with previously reported IRAS 60um excesses. We augment those data with newly obtained IRS spectra of 64 main-sequence stars with MIPS 24um and/or IRAS 25um excesses using the SL (5.2-14.0um) and LL (14.0-38.0um; λ/Δλ~60) modules as part of the program "Characterizing Warm Debris around Main Sequence Stars" (PID 40651 led by PI: J. Houck). For targets not observed as part of our programs, we downloaded Cornell Atlas of Spitzer/Infrared Spectrograph Sources (CASSIS; Lebouteiller et al. 2011ApJS..196....8L) spectra wherever possible. We assembled MIPS 24 and/or 70um photometry for 473 IRS sources to calibrate the IRS spectra and better constrain our targets' global SEDs (see Table 2). (4 data files).

  20. Complete mitochondrial genome of the Pseudogastromyzon jiulongjiangensis Chen (Cypriniformes, Homalopteridae) and phylogenetic analysis of the Cyprinoidei.

    PubMed

    Lv, Yaoping; Zhang, Kaibo; Liu, Ziming; Hu, Zehui; Wang, Kaiwei; Zhou, Haidong

    2016-07-01

    The Pseudogastromyzon jiulongjiangensis Chen (Cypriniformes, Homalopteridae) is a promising ornamental and commercial candidate in China. In this study, the complete mitochondrial genome of P. jiulongjiangensis was first determined. It is 16,571 bp length and consists of 22 tRNA genes, 13 protein-coding genes, two rRNA genes, and a control region. Except for eight tRNA and ND6 genes, all other mitochondrial genes are encoded on the heavy strand. Phylogenetic analysis revealed that P. jiulongjiangensis, Formosania lacustris, and other seven fish first clustered into the Homalopteridae clade. Then, the Homalopteridae and Cobitidae formed the sister group. The Catostomoidae and Cyprinidae constituted the sister branch, which is inconsistent with the previous phenotypic report. It is suggested that the taxonomic research might lose some significant evolutionary characters. This study will contribute to phylogenetic analysis of the Homalopteridae and the natural resources conservation of P. jiulongjiangensis. PMID:27158787

  1. 40 CFR 721.3031 - Boric acid (H3BO3), zinc salt (2=3).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Boric acid (H3BO3), zinc salt (2=3... Substances § 721.3031 Boric acid (H3BO3), zinc salt (2=3). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as boric acid (H3BO3), zinc salt (2=3) (PMN...

  2. 40 CFR 721.3031 - Boric acid (H3BO3), zinc salt (2=3).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Boric acid (H3BO3), zinc salt (2=3... Substances § 721.3031 Boric acid (H3BO3), zinc salt (2=3). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as boric acid (H3BO3), zinc salt (2=3) (PMN...

  3. 40 CFR 721.3031 - Boric acid (H3BO3), zinc salt (2=3).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Boric acid (H3BO3), zinc salt (2=3... Substances § 721.3031 Boric acid (H3BO3), zinc salt (2=3). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as boric acid (H3BO3), zinc salt (2=3) (PMN...

  4. 40 CFR 721.3031 - Boric acid (H3BO3), zinc salt (2=3).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Boric acid (H3BO3), zinc salt (2=3... Substances § 721.3031 Boric acid (H3BO3), zinc salt (2=3). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as boric acid (H3BO3), zinc salt (2=3) (PMN...

  5. 40 CFR 721.3031 - Boric acid (H3BO3), zinc salt (2=3).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Boric acid (H3BO3), zinc salt (2=3... Substances § 721.3031 Boric acid (H3BO3), zinc salt (2=3). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as boric acid (H3BO3), zinc salt (2=3) (PMN...

  6. The role of herpesviruses (BoHV-1 and BoHV-4) and pestiviruses (BVDV and BDV) in ruminant abortion cases in western Turkey.

    PubMed

    Tuncer-Göktuna, Pelin; Alpay, Gizem; Öner, Eda Baldan; Yeşilbağ, Kadir

    2016-06-01

    The economic impact of abortions in ruminant breeders is one of the biggest problems in livestock. Of the infectious agents, viruses, especially herpesviruses and pestiviruses, are the most important causative agents of abortion in ruminants. In the present study, the role of herpesviruses (bovine herpesvirus-1 (BoHV-1), bovine herpesvirus-4 (BoHV-4)) and pestiviruses (bovine viral diarrhea virus (BVDV), border disease virus (BDV)) was investigated in cases of ruminant abortion between 2007 and 2015 in western Turkey. Out of 81 aborted fetal samples (60 calves, 19 lambs, and 2 kids), 42 were positive, which included 31 calves, 9 lambs, and 2 goats; 39 aborted fetal samples were negative for the pestivirus antigen ELISA. BoHV-1 antigen ELISA was positive in 3 cases which included 2 calves and 1 lamb; the remainder 78 cases were negative. Pestivirus and BoHV-1 were positive in 51.85 and 3.70 %, respectively, of the samples. According to PCR analysis, BoHV-4 was not encountered in any of the tested samples. In one of the calf fetus samples, both BVDV and BoHV-1 were positive; in one of the lamb fetus samples, BoHV-1 was positive. There was a much higher level of pestivirus antigen than the other viral agents evaluated in the study (p < 0.0001). The results of this study indicate that pestiviruses are a common viral cause of ruminant abortions in the examined area. PMID:27038195

  7. Comment on “Magnetostratigraphic study of the Kuche Depression, Tarim Basin, and Cenozoic uplift of the Tian Shan Range, Western China” Baochun Huang, John D.A. Piper, Shoutao Peng, Tao Liu, Zhong Li, Qingchen Wang, Rixiang Zhu [Earth Planet. Sci. Lett., 2006, doi:10.1016/j.epsl.2006.09.020

    NASA Astrophysics Data System (ADS)

    Charreau, Julien; Chen, Yan; Gilder, Stuart; Barier, Laurie

    2008-04-01

    The recent publication of "Magnetostratigraphic study of the Kuche Depression, Tarim Basin, and Cenozoic uplift of the Tian Shan Range,Western China" by B.C. Huang, J.D.A. Piper, S.T. Peng, T. Liu, Z. Li, Q.C. Wang, R.X. Zhu [Earth Planet. Sci. Lett., 2006, doi:10.1016/j.epsl.2006.09.020] discusses the Cenozoic uplift history of the Tianshan Mountains by studying the magnetostratigraphy of Paleogene to Neogene continental sediments from two sections located in the Kuche basin at the northern edge of the Tarim basin. To support their conclusion they reinterpreted a magnetostratigraphic study of the Yaha section, which lies ~ 10 km south of their sections, we previously published [J. Charreau, S. Gilder, Y. Chen, S. Dominguez, J.-P. Avouac, S. Sen, M. Jolivet, Y. Li and W. Wang, Magnetostratigraphy of the Yaha section, Tarim Basin (China): 11 Ma acceleration in erosion and uplift of the Tianshan Mountains, Geology 34(3), 2006, 181­184.]. Here, (1) we argue that the interpretations of the sedimentation rate changes they proposed for the Kuche sections are partially invalid, (2) we disagree with their reinterpretation of the age of the Yaha section, and (3) we think that the way they interpret their AMS data is incorrect.

  8. In vitro antibacterial activity and beta-lactamase stability of a new carbapenem, BO-2727.

    PubMed Central

    Inoue, K; Hamana, Y; Mitsuhashi, S

    1995-01-01

    The in vitro activity of BO-2727, a new carbapenem, was compared with those of meropenem, biapenem, imipenem, and ceftazidime. BO-2727 was four- or eightfold more active than the other carbapenems against methicillin-resistant staphylococci and Pseudomonas aeruginosa strains, including imipenem- and ceftazidime-resistant bacteria. BO-2727 was quite stable to penicillinases, cephalosporinases, and oxyiminocephalosporinases, but not to metallo-beta-lactamase. Time-kill studies against Staphylococcus aureus Smith, Escherichia coli ML4707, and P. aeruginosa GN11189 showed that BO-2727 has potent bactericidal activity at concentrations greater than the MIC. PMID:8619591

  9. BoA: a versatile software for bolometer data reduction

    NASA Astrophysics Data System (ADS)

    Schuller, Frédéric

    2012-09-01

    Together with the development of the Large APEX Bolometer Camera (LABOCA) for the Atacama Pathfinder Experiment (APEX), a new data reduction package has been written. This software naturally interfaces with the telescope control system, and provides all functionalities for the reduction, analysis and visualization of bolometer data. It is used at APEX for real time processing of observations performed with LABOCA and other bolometer arrays, providing feedback to the observer. Written in an easy-to-script language, BoA is also used offline to reduce APEX continuum data. In this paper, the general structure of this software is presented, and its online and offline capabilities are described.

  10. Crystal Structure of High-Temperature Phase β-NaSrBO3 and Photoluminescence of β-NaSrBO3:Ce(3.).

    PubMed

    Yi, Huan; Wu, Li; Wu, Liwei; Zhao, Lixia; Xia, Zhiguo; Zhang, Yi; Kong, Yongfa; Xu, Jingjun

    2016-07-01

    α-NaSrBO3 is an excellent phosphor host for phosphor-converted white light-emitting diode (w-LED) application with very interesting properties. However, it undergoes a phase transformation to β-NaSrBO3 at the LED working temperature. In this study, the high-temperature phase β-NaSrBO3 was stabilized to room temperature by introducing Na(+) and Ce(3+) via a high-temperature solid-state reaction method. The crystal structure of β-NaSrBO3 was determined from the powder X-ray diffraction data. It crystallizes in space group P21/c with the following lattice parameters: a = 6.06214(8) Å, b = 5.41005(7) Å, c = 9.1468(1) Å, β = 102.116(1)°, and V = 293.301(7) Å(3). Na and Sr sites are found to be mixed occupied by each other, and the isolated [BO3](3-) anionic groups are distributed in parallel. Ce(3+)-activated β-NaSrBO3:Ce(3+) blue-emitting phosphors were synthesized. The temperature-dependent photoluminescence spectra indicate that the thermal stability of β-NaSrBO3:Ce(3+) is better than that of α-NaSrBO3:Ce(3+) at the same temperature. A near-ultraviolet pumped warm w-LED with a β-NaSrBO3:0.05Ce(3+) phosphor as the blue component was fabricated. The w-LED lamp after illumination at 250 mA gives chromaticity coordinates, a color rendering index, and a correlated color temperature of (0.3821, 0.3430), 92.8, and 3654 K, respectively. PMID:27299933

  11. Towards Transformation of Knowledge and Subjectivity in Curriculum Inquiry: Insights from Chen Kuan-Hsing's "Asia as Method"

    ERIC Educational Resources Information Center

    Lin, Angel M. Y.

    2012-01-01

    Chen's book, "Asia as Method" (Duke University Press, 2010), and his theorization on topics of de-imperialization, de-colonization, de-cold war, as well as on foregrounding epistemologies and frames of reference situated in the diverse contexts in Asia have contributed to empowering scholars and researchers situated not only in Taiwan, but also in…

  12. A comparative assessment of the Chen et al. and Suchey-Brooks pubic aging methods on a North American sample, .

    PubMed

    Fleischman, Julie M

    2013-03-01

    Accurately estimating the age-at-death of adult human skeletons is fundamental in forensic anthropology. This study evaluates the accuracy of two pubic bone age estimation methods-Chen et al. and Suchey-Brooks. Specimens were obtained from a known collection of modern pubic bones curated at the Maricopa County Forensic Science Center in Phoenix, Arizona. A sample of 296 left male pubic bones of European ancestry was statistically evaluated via bias, absolute mean error, and intra- and inter-observer error. Results indicate that the two methods are similar; the Suchey-Brooks method is the most accurate for aging young adults (error c. 7 years), while the Revised Chen et al. method is most accurate for aging middle-age adults (error c. 6 years). Thus, the Chen et al. method is an important contribution to forensic anthropology for aging older adult skeletal remains. There are, however, some limitations such as subjectivity and the intricate scoring system of Chen et al. method. PMID:23425207

  13. Mating and Oviposition Behaviors of Diorhabda elongata deserticola Chen (Chrysomelidae, Coleoptera), an Effective Biocontrol Agent of the Saltcedar

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Diorhabda elongata deserticola Chen is an important biocontrol agent for management of the invasive alien saltcedar in the United States. The mating and oviposition behaviors, including, the relationships between mating frequency and fecundity, and between oviposition style and parasitized eggs, of...

  14. Boronyl Mimics Gold: a Photoelectron Spectroscopy Study

    NASA Astrophysics Data System (ADS)

    Jian, Tian; Lopez, Gary; Wang, Lai-Sheng

    2015-06-01

    Previous studies have found that gold atom and boronyl bear similarities in bonding in many gas phase clusters. B10(BO), B12(BO), B3(BO)n (n=1, 2) were found to possess similar bonding and structures to B10Au, B12Au, B3Aun (n=1, 2), respectively. During the recent photoelectron spectroscopy experiments, the spectra of BiBO- and BiAu- clusters are found to exhibit similar patterns, hinting that they possess similar geometric structures. While BiAu- is a linear molecule, BiBO- is also linear. The similarity in bonding between BiBO- and BiAu- is owing to the fact that Au and BO are monovalent σ ligands. The electron affinities are measured to be 1.79±0.04eV for BiBO- and 1.36±0.02eV for BiAu-. The current results provide new examples for the BO/Au isolobal analogy and enrich the chemistry of boronyl and gold. H.-J. Zhai, C.-Q. Miao, S.-D. Li, L.-S. Wang, J. Phys. Chem. A 2010, 114, 12155-1216 Q. Chen, H. Bai, H.-J. Zhai, S.-D. Li, L.-S. Wang, J. Chem. Phys. 2013, 139, 044308 H. Bai, H.-J. Zhai, S.-D. Li, L.-S. Wang, Phys. Chem. Chem. Phys., 2013, 15, 9646-9653 H.-J. Zhai, Q. Chen, H. Bai, S.-D. Li, L.-S. Wang, Acc. Chem. Res. 2014, 47, 2435-2445

  15. High-pressure x-ray diffraction study of YBO{sub 3}/Eu{sup 3+}, GdBO{sub 3}, and EuBO{sub 3}: Pressure-induced amorphization in GdBO{sub 3}

    SciTech Connect

    Wang, Pei; Xu, Chao; Ren, Xiangting; Lei, Li; Wang, Shanmin; Peng, Fang; Yan, Xiaozhi; Liu, Dongqiong; Wang, Qiming; He, Duanwei; Xiong, Lun; Liu, Jing

    2014-01-28

    Angle-dispersive synchrotron X-ray diffraction measurements were performed on vaterite-type YBO{sub 3}/Eu{sup 3+}, GdBO{sub 3}, and EuBO{sub 3}, respectively, up to 41 GPa at room temperature using a diamond-anvil cell. Pressure-induced amorphization was observed in hexagonal GdBO{sub 3} with a significant compression along the c-axis. Compared to the ions of the distorted GdBO{sub 3} phase, its anions may lose their long-range order prior to the cations at high pressures. Based on the experimental pressure-volume data, the obtained bulk moduli of YBO{sub 3}/Eu{sup 3+} and GdBO{sub 3} are 329 and 321 GPa, respectively, which are more than 90% larger than that of EuBO{sub 3} (167 GPa) and are presumably attributed to Gd{sup 3+} and Y{sup 3+} with a high density of d valence electrons.

  16. The synthesis and crystal structures of the related series of aluminoborates: Co 2.1Al 0.9BO 5, Ni 2AlBO 5, and Cu 2AlBO 5

    NASA Astrophysics Data System (ADS)

    Hriljac, J. A.; Brown, R. D.; Cheetham, A. K.; Satek, L. C.

    1990-02-01

    We report on the growth of single crystals of Ni 2AlBO 5, Cu 2AlBO 5, and the mixed-valent Co 2.1Al 0.9BO 5 from borax fluxes. All of these materials have been studied by single-crystal X-ray diffraction. The nickel and cobalt compounds are isostructural with the natural mineral ludwigite, while the copper compound is a monoclinically distorted variant of this structure. All three compounds show nonrandom disorder of the transition metal and aluminium atoms over four crystallographically distinct metal sites. We discuss the structural effects of this disorder and attempt to rationalize the observed occupancies on the basis of covalent and ionic forces. Ni 2AlBO 5: orthorhombic, a = 12.013(1)Å, b = 9.111(1)Å, c = 2.942(1)Å, space group Pbam, Z = 4, R = 4.07%. Co 2.1Al 0.9BO 5: orthorhombic, a = 12.010(2)Å, b = 9.197(2)Å, c = 2.993(1)Å, space group Pbam, Z = 4, R = 4.44%. Cu 2AlBO 5: monoclinic, a = 9.365(1)Å, b = 11.778(2)Å, c = 3.072(2)Å, β = 97.71(2)°, space group P2 1a, Z = 4, R = 4.59% .

  17. Security analysis of boolean algebra based on Zhang-Wang digital signature scheme

    SciTech Connect

    Zheng, Jinbin

    2014-10-06

    In 2005, Zhang and Wang proposed an improvement signature scheme without using one-way hash function and message redundancy. In this paper, we show that this scheme exits potential safety concerns through the analysis of boolean algebra, such as bitwise exclusive-or, and point out that mapping is not one to one between assembly instructions and machine code actually by means of the analysis of the result of the assembly program segment, and which possibly causes safety problems unknown to the software.

  18. Wang-Landau Algorithm for Continuous Models and Joint Density of States

    SciTech Connect

    Zhou, Chenggang; Schulthess, Thomas C; Torbrugge, S.; Landau, D. P.

    2006-01-01

    We present a modified Wang-Landau algorithm for models with continuous degrees of freedom. We demonstrate this algorithm with the calculation of the joint density of states of ferromagnet Heisenberg models and a model polymer chain. The joint density of states contains more information than the density of states of a single variable-energy, but is also much more time consuming to calculate. We present strategies to significantly speed up this calculation for large systems over a large range of energy and order parameter.

  19. Conodont index fossil Hindeodus changxingensis Wang fingers greatest mass extinction event

    USGS Publications Warehouse

    Metcalfe, I.; Nicoll, R.S.; Wardlaw, B.R.

    2007-01-01

    The marine conodont fossil species, Hindeodus changxingensis Wang, that has a distinctive morphology, is restricted to a very narrow stratigraphic interval essentially from the Permian-Triassic extinction event through the internationally recognized boundary and into the very earliest Triassic. The species is geographically widespread in the Tethyan Region, from Italy to South China, and serves as a characteristic index fossil to reliably identify this short but critical interval that encompasses the greatest mass extinction of life on earth and the boundary between the Paleozoic and Mesozoic Eras. ?? 2007 Nanjing Institute of Geology and Palaeontology, CAS.

  20. Protein folding of the H0P model: A parallel Wang-Landau study

    SciTech Connect

    Shi, Guangjie; Wuest, Thomas; Li, Ying Wai; Landau, David P

    2015-01-01

    We propose a simple modication to the hydrophobic-polar (HP) protein model, by introducing a new type of monomer, "0", with intermediate hydrophobicity of some amino acids between H and P. With the replica-exchange Wang-Landau sampling method, we investigate some widely studied HP sequences as well as their H0P counterparts and observe that the H0P sequences exhibit dramatically reduced ground state degeneracy and more signicant transition signals at low temperature for some thermodynamic properties, such as the specific heat.

  1. [Analysis on professor WANG Juyi's crevice theory from Tao Teh King].

    PubMed

    Luo, Lu; Wang, Juyi

    2015-10-01

    The crevice theory proposed by professor WANG Juyi is analyzed in this article. In the crevice theory, it is believed that the meridians are located among "skin, pulse, flesh, tendon and bone", and the crevice is the path for the transportation of qi-blood and body fluid in the body, which is the essential condition for vital movement. This is in agreement with the idea of "action through inaction" from Tao Teh King. Based on crevice theory, the abnormalities of meridians can reflex the deficiency and excess of diseases, and regulating meridians is a significant way to treat diseases, and maintaining smooth meridian is important for healthcare. PMID:26790228

  2. Super-radiant super-resolving displacement estimation via multiple photons by the Wang's method

    NASA Astrophysics Data System (ADS)

    Xia, Li-Xin; Abdureyim, Muhammad-Tursun; Liu, Run-Qin; Yu, Sheng-Qing; Guo, Ling; Zhou, Xiang-Ling

    2015-06-01

    In this paper, we propose a super-radiant measurement scheme to achieve Heisenberg limit super-resolving displacement estimation by encoding multiple light momenta into a three-level atomic ensemble with multiple ? photons. And by the Wang's method (Phys. Rev. Lett. 2014, 113, 083601), we use ? coherent pulses to prepare a ?-excitation super-radiant state in a super-position of two timed Dicke states that are ? light momenta apart in the momentum space. The phase difference between these two states induced by a uniform displacement of the atomic ensemble has ? sensitivity. In the end, we introduce two experiments based on Ramsey interferometry in crystal and in ultracold atoms.

  3. An L1-script-transfer-effect fallacy: a rejoinder to Wang et al. (2003).

    PubMed

    Yamada, Jun

    2004-09-01

    Do different L1 (first language) writing systems differentially affect word identification in English as a second language (ESL)? Wang, Koda, and Perfetti [Cognition 87 (2003) 129] answered yes by examining Chinese students with a logographic L1 background and Korean students with an alphabetic L1 background for their phonological and orthographic processing skills on English word identification. Such a conclusion is premature, however. We propose that the L1 phonological system (rather than the L1 writing system) of the learner largely accounts for cognitive processes in learning to read a second language (L2). PMID:15147932

  4. Security analysis of boolean algebra based on Zhang-Wang digital signature scheme

    NASA Astrophysics Data System (ADS)

    Zheng, Jinbin

    2014-10-01

    In 2005, Zhang and Wang proposed an improvement signature scheme without using one-way hash function and message redundancy. In this paper, we show that this scheme exits potential safety concerns through the analysis of boolean algebra, such as bitwise exclusive-or, and point out that mapping is not one to one between assembly instructions and machine code actually by means of the analysis of the result of the assembly program segment, and which possibly causes safety problems unknown to the software.

  5. Comments on "Adaptive resolution simulation in equilibrium and beyond" by H. Wang and A. Agarwal

    NASA Astrophysics Data System (ADS)

    Klein, R.

    2015-09-01

    Wang and Agarwal (Eur. Phys. J. Special Topics, this issue, 2015, doi: 10.1140/epjst/e2015-02411-2) discuss variants of Adaptive Resolution Molecular Dynamics Simulations (AdResS), and their applications. Here we comment on their report, addressing scaling properties of the method, artificial forcings implemented to ensure constant density across the full simulation despite changing thermodynamic properties of the simulated media, the possible relation between an AdResS system on the one hand and a phase transition phenomenon on the other, and peculiarities of the SPC/E water model.

  6. Modern process study on Chen Co and Ranwu Lake of Tibetan Plateau

    NASA Astrophysics Data System (ADS)

    Ju, J.

    2013-12-01

    Lakes are important junctions of geospheres. There are many lakes distributed on the Tibetan Plateau (TP). Lake sediment is one of the important media for retrieving the past environmental changes. Because of the uniqueness of environment of the TP, sediment, water and ecological system in lakes has local characteristic inevitably. Modern process research on different lakes will benefit interpreting the proxies more accurately. The development of observation station makes the observation and sampling more convenient. Modern process of lakes can be fulfilled in two ways, spatial or seasonal variation study, with a same aim finding out the dominant factors controlling the variations. Chen Co is a closed lake locating at inland area of southern Tibet. Ranwu Lake is an open lake locating at outflow area of SE Tibet. In this study, I studied the spatial and (or) seasonal variation of lake water and sediment in the two distinct types of lakes to make clear the mechanism of modern process. Particular attention was given to the pattern and degree of influence of rivers supplied by glaciers on lakes. Preliminary conclusions are outlined as follow: (1) In the lakes with glacier melt supplying rivers, the patterns of supply of the rivers to the lake are different. In close lake Chen Co, the influence of glacier melt is mainly reflected in the south lake area. In the open lake Ranwu Lake, the influence is comprehensive and direct. This difference influencing patterns how the lake sediments reflected the glacier melt under the past environmental changes. (2) The supply of Kaluxiong Qu River, supplied mainly by glacier melt, to Chen co has North-South difference: more directly to south lake area, reflecting by lower value of conductivity and pH, finer grain size and west to east transporting trend, greater deposition rate, more allogenic fine sediments, not obvious biological and endogenic deposition there. This enlightens the site selection for lake cores and interpretation of

  7. 75 FR 8310 - Defense Acquisition University (DAU) Board of Visitors (BoV) Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-24

    ... of the Secretary Defense Acquisition University (DAU) Board of Visitors (BoV) Meeting AGENCY: Defense Acquisition University, DoD. ACTION: Meeting notice. SUMMARY: The next meeting of the Defense Acquisition University (DAU) Board of Visitors (BoV) will be held at DAU Headquarters at Fort Belvoir, Virginia....

  8. Source of the North Pacific "boing" sound attributed to minke whales.

    PubMed

    Rankin, Shannon; Barlow, Jay

    2005-11-01

    During a recent cetacean survey of the U.S. waters surrounding the Hawaiian Islands, the probable source of the mysterious "boing" sound of the North Pacific Ocean was identified as a minke whale, Balaenoptera acutorostrata. Examination of boing vocalizations from three research surveys confirms previous work that identified two distinct boing vocalization types in the North Pacific. The eastern boing (n = 22) has a pulse repetition rate of 92 s(-1) and a duration of 3.6 s and was found only east of 138 degrees W. The central boing (n = 106) has a pulse repetition rate of 115 s(-1) and a duration of approximately 2.6 s and was found only west of 135 degrees W. Central boing vocalizations produced by a single source (n = 84) indicate that variation in repetition rate and duration of the calls of the individual were not significantly different than the variation among individuals of the same boing type. Despite a slight latitudinal overlap in the vocalizations, pulse repetition rates of the eastern and central boings were distinct. PMID:16334704

  9. Current controlled negative differential resistance behavior in Co2FeO2BO3 and Fe3O2BO3 single crystals

    NASA Astrophysics Data System (ADS)

    dos Santos, E. C.; Freitas, D. C.; Fier, I.; Fernandes, J. C.; Continentino, M. A.; de Oliveira, A. J. A.; Walmsley, L.

    2016-03-01

    I-V curves showing negative differential resistance (NDR) are reported for single crystals of Co2FeO2BO3 at 315 K and 290 K and for Fe3O2BO3 at 300 K, 260 K and 220 K. Resistivity measurements are presented for both systems, parallel and perpendicular to the c axis, in the range 315-120 K. The high hysteretic behavior of the I-V curves in Co2FeO2BO3 around room temperature is discussed and the heat dissipated is estimated, suggesting an increase in the sample temperature of almost 22 K for the I-V curve at 315 K and a dominant contribution of Joule self-heating for the observed NDR. In contrast, insignificant hysteresis is observed on the I-V curves of Fe3O2BO3 around room temperature. The depinning of charge order domains is suggested as the main contribution to the NDR phenomenon for Fe3O2BO3. The high reproducibility of the NDR in the Fe3O2BO3 single crystal allows its use as a low frequency oscillator, as it is demonstrated.

  10. Face-capping μ3-BO in B6(BO)7-: boron oxide analogue of B6H7- with rhombic 4c-2e bonds.

    PubMed

    Guo, Jin-Chang; Lu, Hai-Gang; Zhai, Hua-Jin; Li, Si-Dian

    2013-11-14

    Using the first-principle approaches, we predict a B6(BO)7(-) cluster with a face-capping μ(3)-BO, which is the boron oxide analogue of closo-B6H7(-) with a face-capping μ(3)-H. Detailed topological analysis of electron density clearly reveals the existence of three rhombic 4c-2e bonds around the B/H apex in both C3v B6(BO)7(-) and C3v B6H7(-), which possesses similar electron densities at their bond and ring critical points. The adaptive natural density partitioning (AdNDP) analysis provides a direct and visual picture of the B-B-B-B/H 4c-2e bonds for the first time. Adiabatic and vertical electron detachment energies of the concerned monoanions are calculated to facilitate their future photoelectron spectroscopy measurements and characterizations. The presence of the B6(BO)7(-) and B6H7(-) clusters extends the BO/H isolobal analogy to the whole μ(n)-BO/H series (n = 1, 2, and 3) and enriches the chemistry of boronyl. PMID:24147988

  11. Efficient combination of Wang-Landau and transition matrix Monte Carlo methods for protein simulations.

    PubMed

    Ghulghazaryan, Ruben G; Hayryan, Shura; Hu, Chin-Kun

    2007-02-01

    An efficient combination of the Wang-Landau and transition matrix Monte Carlo methods for protein and peptide simulations is described. At the initial stage of simulation the algorithm behaves like the Wang-Landau algorithm, allowing to sample the entire interval of energies, and at the later stages, it behaves like transition matrix Monte Carlo method and has significantly lower statistical errors. This combination allows to achieve fast convergence to the correct values of density of states. We propose that the violation of TTT identities may serve as a qualitative criterion to check the convergence of density of states. The simulation process can be parallelized by cutting the entire interval of simulation into subintervals. The violation of ergodicity in this case is discussed. We test the algorithm on a set of peptides of different lengths and observe good statistical convergent properties for the density of states. We believe that the method is of general nature and can be used for simulations of other systems with either discrete or continuous energy spectrum. PMID:17195159

  12. Wormholes supported by phantom energy from Shan-Chen cosmological fluids

    NASA Astrophysics Data System (ADS)

    Wang, Deng; Meng, Xin-He

    2016-03-01

    In the present paper, the exact solutions of spherically symmetrical Einstein field equations describing wormholes supported by phantom energy that violates the null energy condition from Shan-Chen background fluid are obtained. We have considered the important case of the model parameter ψ ≈ 1, which corresponds to the "saturation effect", and this regime corresponds to an effective form of "asymptotic freedom" for the fluids, but occurring at cosmological rather than subnuclear scales. Then we investigate the allowed range for the values of the model parameters g and ω when the spacetime metrics describe wormholes and discuss the possible singularities of the solutions, finding that the obtained spacetimes are geodesically complete. Furthermore, we construct two traversable wormholes through matching our obtained interior solutions to the exterior Schwarzschild solutions and analyze the traversablities of the wormholes. Finally, we consider the case of anisotropic pressure and discover that the transverse pressure also crosses the phantom divide -1 with the growth of the wormhole dimension, and it tends to be the same as the radial pressure with the growth of the wormhole radius.

  13. Antibodies to Influenza A Viruses in Wintering Snow Geese (Chen caerulescens) in Texas.

    PubMed

    Wong, Jessica K; Wilcox, Benjamin R; Fojtik, Alinde; Poulson, Rebecca L; Stallknecht, David E

    2016-05-01

    Wild waterfowl in the order Anseriformes are recognized reservoirs for influenza A viruses (IAVs); however, prevalence of infection can vary greatly by species. Few isolates of IAVs have been reported from snow geese (Chen caerulescens), and generally they have not been regarded as an important component of this reservoir. In February 2013, 151 combined cloacal and oropharangeal swabs and 147 serum samples were collected from snow geese wintering on the Gulf coast of Texas. None of the swab samples tested positive by virus isolation, but antibodies to IAVs were detected in 87 (59%) birds tested by competitive blocking ELISA (bELISA). To further characterize these detected antibodies, positive samples were tested by virus microneutralization (MN) for antibodies to viruses representing 14 hemagglutinin subtypes (HA1-HA12, H14, and H15). By MN, antibodies to H1 (n = 41; 47%), H5 (n = 32; 37%), H6 (n = 49; 56%), H9 (n = 50; 57%), and H12 (n = 24; 28%) were detected. Snow goose populations have increased in North America since the 1960s, and their association with agricultural lands provides a potential indirect source of IAV infection for domestic poultry. This potential, as well as the detection of antibodies to HA subtypes H5, H9, and H12 that are not well represented in other waterfowl species, suggests that further snow geese surveillance is indicated. PMID:27309076

  14. Bulk Modulus of Spherical Palladium Nanoparticles by Chen-Mobius Lattice Inversion Method

    NASA Astrophysics Data System (ADS)

    Abdul-Hafidh, Esam

    2015-03-01

    Palladium is a precious and rare element that belongs to the Platinum group metals (PGMS) with the lowest density and melting point. Numerous uses of Pd in dentistry, medicine and industrial applications attracted considerable investment. Preparation and characterization of palladium nanoparticles have been conducted by many researchers, but very little effort has taken place on the study of Pd physical properties, such as, mechanical, optical, and electrical. In this study, Chen-Mobius lattice inversion method is used to calculate the cohesive energy and modulus of palladium. The method was employed to calculate the cohesive energy by summing over all pairs of atoms within palladium spherical nanoparticles. The modulus is derived from the cohesive energy curve as a function of particles' sizes. The cohesive energy has been calculated using the potential energy function proposed by (Rose et al., 1981). The results are found to be comparable with previous predictions of metallic nanoparticles. This work is supported by the Royal commission at Yanbu- Saudi Arabia.

  15. Multiphase fluid simulations through porous rock using Shan-Chen type lattice Boltzmann method

    NASA Astrophysics Data System (ADS)

    Qohar, Ulin Nuha Abdul; Latief, Fourier Dzar Eljabbar; Fauzi, Umar

    2015-09-01

    Fluid flow with multiphase components is one of the daily problems that interesting to learn and widely used in various fields, one of them in rock physics. Euler approach and Lagrange approach, the two models are applied to study the fluid flow, which often known as the microscopic and macroscopic approaches. Lattice Boltzmann Method combines the advantages and appropriate of both approaches, that is used as a more efficient model approach, also known as mesoscopic. The LB method has been used to model the two-phase fluid flow with different viscosities using the Shan-Chen model, this model explain the interaction between two different fluid phases. Validated numerical models compiled using two ways, namely analytical models and physical models. Based on this research, numerical models are designed to meet the analytical model with an error on the lattice at the edge of the lattice. When compared with physical models, numerical models have qualitatively suitability. Based on the results of the validation of numerical models, modeling is done to the image of porous rock which gives the results of multiphase fluid flow profile inside the pore. Moreover, the results obtained indicate that there are effective pores that fluid can not be drained.

  16. Apoptosis of human pancreatic carcinoma cell-1 cells induced by Yin Chen Hao Decoction

    PubMed Central

    Zhou, Hai-Bo; Chen, Jing-Ming; Shao, Li-Ming; Chen, Zhi-Gang

    2015-01-01

    AIM: To evaluate human pancreatic carcinoma cell line (PANC-1) cells apoptosis and Bcl-2 and Bax expression induced by Yin Chen Hao Decoction (YCHD). METHODS: The cell growth inhibitory rate was determined by MTT assay. Apoptosis of PANC-1 cells before and after treatment with YCHD was determined by TUNEL staining. Expression of the apoptosis-associated genes, Bcl-2 and Bax, was detected by immunohistochemical staining and reverse transcription -PCR. RESULTS: YCHD inhibited the growth of PANC-1 cells. Following treatment with YCHD for 24-96 h, the apoptotic rate of PANC-1 cells increased with time. In addition, the positive rate of Bcl-2 protein expression decreased in a time-dependent manner, whereas the positive rate of Bax protein expression increased in a time-dependent manner. Following treatment of with YCHD for 24-96h, expression of BAX mRNA increased gradually and BCL-2 mRNA reduced gradually with time. CONCLUSION: YCHD induces apoptosis of PANC-1 cells mediated in part via up-regulation of BAX and down-regulation of BCL-2. PMID:26217086

  17. Impact of Bovine Herpesvirus 4 (BoHV-4) on Reproduction.

    PubMed

    Chastant-Maillard, S

    2015-06-01

    Bovine herpesvirus 4 (BoHV-4) is increasingly considered as responsible for various reproductive troubles. This virus infects blood mononuclear cells and displays a specific tropism for vascular endothelia, mammary tissue, endometrium and foetal tissues. Viral multiplication can be reactivated by corticosteroids or stress, both factors present at calving. BoHV-4 has been isolated in a large variety of clinical cases, primarily metritis, vaginitis and mastitis, but also endometritis, abortion and orchitis. Its impact on reproductive performance has been suggested by several epidemiological studies: seroprevalence against BoHV-4 is higher in aborted females and in repeat breeders. Nevertheless, its intrinsic pathogenic power seems low, symptoms developing only when BoHV-4 cooperates with bacteria: within the uterus or mammary gland. BoHV-4 is rather currently considered as a cofactor for the development of an inflammatory reaction initiated by bacteria. PMID:23998345

  18. Luminescent Characteristics of LiSrBO3:Eu3+ Phosphor for White Light Emitting Diode

    NASA Astrophysics Data System (ADS)

    Li, Pan-Lai; Wang, Zhi-Jun; Yang, Zhi-Ping; Guo, Qing-Lin

    2009-04-01

    LiSrBO3:Eu3+ phosphor is synthesized by a high solid-state reaction method, and its luminescent characteristics are investigated. The emission and excitation spectra of LiSrBO3:Eu3+ phosphors exhibit that the phosphors can be effectively excited by near ultraviolet (401 nm) and blue (471 nm) light, and emit 615 nm red light. The effect of Eu3+ concentration on the emission spectrum of LiSrBO3:Eu3+ phosphor is studied; the results show that the emission intensity increases with increasing Eu3+ concentration, and then decreases because of concentration quenching. It reaches the maximum at 3 mol%, and the concentration self-quenching mechanism is the dipoledipole interaction according to the Dexter theory. Under the conditions of charge compensation Li+, Na+ or K+ incorporated in LiSrBO3, the luminescent intensities of LiSrBO3:Eu3+ phosphor are enhanced.

  19. Spin-Phonon and Electron-Phonon Interactions in Multiferroic GdFe3 (BO3)4 and TbFe3 (BO3)4 Evidenced by IR Reflection Spectroscopy

    NASA Astrophysics Data System (ADS)

    Klimin, S. A.; Kashchenko, M. A.; Bezmaternykh, L. N.

    2016-03-01

    We study temperature-dependent polarized reflection spectra of multiferroic GdFe3 (BO3)4 and TbFe3 (BO3)4 single crystals. Signatures of spin-lattice interactions in both compounds and of a formation of the electron-phonon coupled mode in TbFe3 (BO3)4 are discussed.

  20. In vivo image analysis of BoHV-4-based vector in mice.

    PubMed

    Franceschi, Valentina; Stellari, Fabio Franco; Mangia, Carlo; Jacca, Sarah; Lavrentiadou, Sophia; Cavirani, Sandro; Heikenwalder, Mathias; Donofrio, Gaetano

    2014-01-01

    Due to its biological characteristics bovine herpesvirus 4 (BoHV-4) has been considered as an appropriate gene delivery vector. Its genomic clone, modified as a bacterial artificial chromosome (BAC), is better genetically manipulable and can be used as an efficient gene delivery and vaccine vector. Although a large amount of data have been accumulated in vitro on this specific aspect, the same cannot be asserted for the in vivo condition. Therefore, here we investigated the fate of a recombinant BoHV-4 strain expressing luciferase (BoHV-4-A-CMVlucΔTK) after intraperitoneal or intravenous inoculation in mice, by generating a novel recombinant BoHV-4 expressing luciferase (BoHV-4-A-CMVlucΔTK) and by following the virus replication through in vivo imaging analysis. BoHV-4-A-CMVlucΔTK was first characterized in vitro where it was shown, on one hand that its replication properties are identical to those of the parental virus, and on the other that the transduced/infected cells strongly express luciferase. When BoHV-4-A-CMVlucΔTK was inoculated in mice, either intraperitoneally or intravenously, BoHV-4-A-CMVlucΔTK infection/transduction was exclusively localized to the liver, as detected by in vivo image analysis, and in particular almost exclusively in the hepatocytes, as determined by immuno-histochemistry. These data, that add a new insight on the biology of BoHV-4 in vivo, provide the first indication for the potential use of a BoHV-4-based vector in gene-transfer in the liver. PMID:24752229

  1. In Vivo Image Analysis of BoHV-4-Based Vector in Mice

    PubMed Central

    Franceschi, Valentina; Stellari, Fabio Franco; Mangia, Carlo; Jacca, Sarah; Lavrentiadou, Sophia; Cavirani, Sandro; Heikenwalder, Mathias; Donofrio, Gaetano

    2014-01-01

    Due to its biological characteristics bovine herpesvirus 4 (BoHV-4) has been considered as an appropriate gene delivery vector. Its genomic clone, modified as a bacterial artificial chromosome (BAC), is better genetically manipulable and can be used as an efficient gene delivery and vaccine vector. Although a large amount of data have been accumulated in vitro on this specific aspect, the same cannot be asserted for the in vivo condition. Therefore, here we investigated the fate of a recombinant BoHV-4 strain expressing luciferase (BoHV-4-A-CMVlucΔTK) after intraperitoneal or intravenous inoculation in mice, by generating a novel recombinant BoHV-4 expressing luciferase (BoHV-4-A-CMVlucΔTK) and by following the virus replication through in vivo imaging analysis. BoHV-4-A-CMVlucΔTK was first characterized in vitro where it was shown, on one hand that its replication properties are identical to those of the parental virus, and on the other that the transduced/infected cells strongly express luciferase. When BoHV-4-A-CMVlucΔTK was inoculated in mice, either intraperitoneally or intravenously, BoHV-4-A-CMVlucΔTK infection/transduction was exclusively localized to the liver, as detected by in vivo image analysis, and in particular almost exclusively in the hepatocytes, as determined by immuno-histochemistry. These data, that add a new insight on the biology of BoHV-4 in vivo, provide the first indication for the potential use of a BoHV-4-based vector in gene-transfer in the liver. PMID:24752229

  2. Microsolvation of LiBO2 in water: anion photoelectron spectroscopy and ab initio calculations.

    PubMed

    Zeng, Zhen; Hou, Gao-Lei; Song, Jian; Feng, Gang; Xu, Hong-Guang; Zheng, Wei-Jun

    2015-04-14

    The microsolvation of LiBO2 in water was investigated by conducting anion photoelectron spectroscopy and ab initio studies on the LiBO2(H2O)n(-) (n = 0-5) clusters. By comparing calculations with experiments, the structures of these clusters and their corresponding neutrals were assigned, and their structural evolutions were revealed. During the anionic structural evolution with n increasing to 5, hydroxyborate and metaborate channels were identified and the metaborate channel is more favorable. For the hydroxyborate structures, the anionic Li(+)-BO2(-) ion pair reacts with a water molecule to produce the LiBO(OH)2(-) moiety and three water molecules tend to dissolve this moiety. In the metaborate channel, two types of solvent-separated ion pair (SSIP) geometries were determined as the ring-type and linear-type. The transition from the contact ion pair (CIP) to the ring-type of SSIP starts at n = 3, while that to the linear-type of SSIP occurs at n = 4. In neutral LiBO2(H2O)n clusters, the first water molecule prefers to react with the Li(+)-BO2(-) ion pair to generate the LiBO(OH)2 moiety, analogous to the bulk crystal phase of α-LiBO2 with two O atoms substituted by two OH groups. The Li-O distance in the LiBO(OH)2 moiety increases with the increasing number of water molecules and elongates abruptly at n = 4. Our studies provide new insight into the initial dissolution of LiBO2 salt in water at the molecular level and may be correlated to the bulk state. PMID:25758204

  3. Absolute and geometric parameters of contact binary BO Arietis

    NASA Astrophysics Data System (ADS)

    Gürol, B.; Gürsoytrak, S. H.; Bradstreet, D. H.

    2015-08-01

    We present the results of our investigation on the geometrical and physical parameters of the W UMa type binary system BO Ari from analyzed CCD (BVRI) light curves and radial velocity data. The photometric data were obtained in 2009 and 2010 at Ankara University Observatory (AUO) and the spectroscopic observations were made in 2007 and 2010 at TUBITAK National Observatory (TUG). These light and radial velocity observations were analyzed simultaneously by using the Wilson-Devinney (2013 revision) code to obtain absolute and geometrical parameters. The system was determined to be an A-type W UMa system. Combining our photometric solution with the spectroscopic data we derived masses and radii of the eclipsing system to be M1 = 0.995M⊙,M2 = 0.189M⊙,R1 = 1.090R⊙ and R2 = 0.515R⊙ . Finally, we discuss the evolutionary status of the system.

  4. Home birth and hospital birth trends in Bo, Sierra Leone.

    PubMed

    Jacobsen, Kathryn H; Abdirahman, Hafsa A; Ansumana, Rashid; Bockarie, Alfred S; Bangura, Umaru; Jimmy, David Henry; Malanoski, Anthony P; Sundufu, Abu James; Stenger, David A

    2012-06-01

    As of April 2010, all maternity care at government healthcare facilities in Sierra Leone is provided at no cost to patients. In late 2010, we conducted a community health census of 18 sections of the city of Bo (selected via randomized cluster sampling from 68 total sections). Among the 3421 women with a history of pregnancy who participated in the study, older women most often reported having a history of both home and hospital deliveries, while younger women showed a preference for hospital births. The proportion of lastborn children delivered at a healthcare facility increased from 71.8% of offspring 10-14 years old to 81.1% of those one to nine years old and 87.3% of infants born after April 2010. These findings suggest that the new maternal healthcare initiative has accelerated an existing trend toward a preference for healthcare facility births, at least in some urban parts of Sierra Leone. PMID:22375565

  5. Notes on Metaphire multitheca (Chen, 1938) (Oligochaeta, Megascolecidae) recorded from Vietnam, with descriptions of two new species

    PubMed Central

    Nguyen, Anh D.; Nguyen, Tung T.

    2015-01-01

    Abstract The paper deals with Pheretima multitheca multitheca Chen, 1938 recorded from Vietnam (non Pheretima multitheca Chen, 1938 now in Metaphire from Hainan Island). As a result, a new species, Amynthas erroneous sp. n., is revealed from materials which were previously misidentified as Pheretima multitheca multitheca. The new species is obviously distinguished from other Amynthas species by multiple spermathecal pores lateroventral in intersegments 5/6/7/8/9, and presence of two pairs of crescentic genital markings in xviii. In addition, another new species, Amynthas nhonmontis sp. n., is described and easily recognized by multiple spermathecal pores ventral in intersegments 5/6/7/8 and three pairs of genital markings in xvii, xix and xx. PMID:26085799

  6. Performance of Replica-Exchange Wang-Landau Sampling for the 2D Ising Model: A Brief Survey

    SciTech Connect

    Zhao, Yiwei; Cheung, Siu Wun; Li, Ying Wai; Eisenbach, Markus

    2014-01-01

    We report a brief performance study of the replica-exchange Wang-Landau algorithm, a recently proposed parallel realization of Wang-Landau sampling, using the 2D Ising model as a test case. The simulation time is found to scale inversely with the square root of the number of subwindows (and thus number of processors) used to span the global parameter space. We also investigate the time profiles for random walkers in dierent subwindows to complete iterations, which will aid the development of and adaptive load-balancing scheme.

  7. Robustness of the Chen-Dougherty-Bittner procedure against non-normality and heterogeneity in the coefficient of variation.

    PubMed

    Powell, Douglas A; Anderson, Lucy M; Cheng, Robert Y S; Alvord, W Gregory

    2002-10-01

    Chen, Dougherty, and Bittner [Y. Chen, E. R. Dougherty, and M. L. Bittner, J. Biomed. Opt. 2(4), 364-374 (1997)] provided the derivation of a probability density function (PDF) for a signal ratio from a DNA microarray. This PDF is potentially useful for testing whether a pair of signals from the same gene has a common mean. The derivation of the PDF assumes the normality of all signal distributions and a common coefficient of variation (CV) for all signals within a microarray. The testing procedure requires the calculation of a common confidence interval for a microarray, based on a maximum likelihood estimator of the "common" CV, and the determination of whether or not a ratio for a particular gene falls within this interval. This study used Monte Carlo techniques and demonstrated that the procedure is robust to violations of normality and also to constancy in the coefficients of variation. A closer examination of the dynamics of the procedure found that the robustness was the result of offsetting effects. The size of the confidence interval was increased as a result of higher estimates of the common CV, as the actual CV pattern became heterogeneous. This effect mitigated the inflation in the size of the ratio as a result of increasing CV heterogeneity. These findings suggest that the Chen-Dougherty-Bittner procedure may be used even if underlying assumptions do not hold. PMID:12421134

  8. Moult migration of emperor geese Chen canagica between Alaska and Russia

    USGS Publications Warehouse

    Hupp, J.W.; Schmutz, J.A.; Ely, C.R.; Syroechkovskiy, E.E., Jr.; Kondratyev, A.V.; Eldridge, W.D.; Lappo, E.

    2007-01-01

    We studied reproductive success and post-breeding movements of 32 adult female emperor geese Chen canagica that were marked with satellite radio transmitters on their nesting area on the Yukon-Kuskokwim Delta (YKD), Alaska 2000–2004. All 16 females that failed to successfully reproduce departed the YKD and moulted remiges either on the north coast of the Chukotka Peninsula, Russia (n=15), or on St. Lawrence Island, Alaska (n=1). Of 16 females that successfully nested, one migrated to Russia following hatch whereas the remainder stayed on the YKD. While moulting on the Chukotka Peninsula, emperor geese with satellite transmitters primarily used coastal lagoons west of Kolyuchin Bay. We observed 21,150 adult-plumaged emperor geese during aerial surveys in Chukotka in 2002. Most (95%) were in the same region used by geese that had been marked with satellite transmitters in Alaska. The number of emperor geese observed in Russia was comparable to our estimate of ≥20,000 adults that either do not nest or nest unsuccessfully each year on the YKD, suggesting that most nonproductive adults, or ≥28% of the adult population departs the YKD to moult elsewhere. The number of moult migrants may be substantially higher in years of poor reproductive success or if adult-plumaged birds that are not of breeding age also leave the YKD. Moult migration of emperor geese between Alaska and Russia is likely substantially greater than previously believed. Russian moulting habitats are important to the North American population of emperor geese and events that affect survival of geese in Russia could impact population trends on the YKD. Protection of coastal lagoons on the north coast of Chukotka is warranted.

  9. Aktivitätsmessung auf nukleinsäuremodifizierten Oberflächen

    NASA Astrophysics Data System (ADS)

    Schmidt, Peter Michael

    2003-06-01

    Im Bereich der medizinischen Diagnostik spielen DNA-Chips eine immer wichtigere Rolle. Dabei werden Glas- oder Silikon-Oberflächen mit Tausenden von einzelsträngigen DNA-Fragmenten, sog. Sonden, bestückt, die mit den passenden DNA-Fragmenten in der zugefügten Patientenprobe verschmelzen. Die Auswertung solcher Messungen liefert die Diagnose für Krankheiten wie z.B. Krebs, Alzheimer oder für den Nachweis pathogener Erreger. Durch fortschreitende Miniaturisierung dieser Meßsysteme können bis zu 40.000 Genfragmente des Menschen in einer einzigen Messung analysiert werden. Neben den DNA-Fragmenten können Bio-Chips auch für andere biologische Komponenten wie Antikörper und Proteine eingesetzt werden, wobei bei letzteren neben der Bindung auch die Aktivität ein wichtiger Diagnoseparamter ist. Am Fraunhofer-Institut für medizinische Technik und am Lehrstuhl für Analytische Biochemie der Universität Potsdam wurden im Rahmen einer Doktorarbeit Methoden entwickelt, die es ermöglichen auf nukleinsäuremodifizierten Sensoroberflächen die Aktivität von Proteinen zu messen. Es wurden Nukleinsäuren auf Oberflächen optischer Sensoren verankert. Diese fungierten als Rezeptor für die Proteine sowie auch als Substrat für Restriktionsenzyme, die Nukleinsäuren schneiden und Polymerasen, die Nukleinsäuren synthetisieren und verlängern können. Seine Anwendung fand diese Messmethode in der Messung der Aktivität des Proteins Telomerase, das in 90% aller Tumore erhöhte Aktivität gegenüber gesunden Zellen aufweist. Die Vorteile dieses neuen Assays gegenüber älteren Methoden liegt im Verzicht auf radioaktiv-markierten Komponenten und einer deutlich verkürzten Analysezeit. Die Arbeit schliesst mit einem funktionsfähigen Nachweis der Telomeraseaktivität im Zellextrakt von gesunden und kranken Zellen. Der direkte Einfluß von Hemmstoffen auf die Aktivität konnte sichtbar gemacht werden, und steht daher bei der Entwicklung neuer Tumor-Diagnostika und

  10. Aktivitätsmessung auf nukleinsäuremodifizierten Oberflächen

    NASA Astrophysics Data System (ADS)

    Schmidt, Peter Michael

    2003-06-01

    Im Bereich der medizinischen Diagnostik spielen DNA-Chips eine immer wichtigere Rolle. Dabei werden Glas- oder Silikon-Oberflächen mit Tausenden von einzelsträngigen DNA-Fragmenten, sog. Sonden, bestückt, die mit den passenden DNA-Fragmenten in der zugefügten Patientenprobe verschmelzen. Die Auswertung solcher Messungen liefert die Diagnose für Krankheiten wie z.B. Krebs, Alzheimer oder für den Nachweis pathogener Erreger. Durch fortschreitende Miniaturisierung dieser Meßsysteme können bis zu 40.000 Genfragmente des Menschen in einer einzigen Messung analysiert werden. Neben den DNA-Fragmenten können Bio-Chips auch für andere biologische Komponenten wie Antikörper und Proteine eingesetzt werden, wobei bei letzteren neben der Bindung auch die Aktivität ein wichtiger Diagnoseparamter ist. Am Fraunhofer-Institut für medizinische Technik und am Lehrstuhl für Analytische Biochemie der Universität Potsdam wurden im Rahmen einer Doktorarbeit Methoden entwickelt, die es ermöglichen auf nukleinsäuremodifizierten Sensoroberflächen die Aktivität von Proteinen zu messen. Es wurden Nukleinsäuren auf Oberflächen optischer Sensoren verankert. Diese fungierten als Rezeptor für die Proteine sowie auch als Substrat für Restriktionsenzyme, die Nukleinsäuren schneiden und Polymerasen, die Nukleinsäuren synthetisieren und verlängern können. Seine Anwendung fand diese Messmethode in der Messung der Aktivität des Proteins Telomerase, das in 90% aller Tumore erhöhte Aktivität gegenüber gesunden Zellen aufweist. Die Vorteile dieses neuen Assays gegenüber älteren Methoden liegt im Verzicht auf radioaktiv-markierten Komponenten und einer deutlich verkürzten Analysezeit. Die Arbeit schliesst mit einem funktionsfähigen Nachweis der Telomeraseaktivität im Zellextrakt von gesunden und kranken Zellen. Der direkte Einfluß von Hemmstoffen auf die Aktivität konnte sichtbar gemacht werden, und steht daher bei der Entwicklung neuer Tumor-Diagnostika und

  11. Mechanism of enhanced antipseudomonal activity of BO-2727, a new injectable 1-beta-methyl carbapenem.

    PubMed Central

    Hazumi, N; Fuse, A; Matsuda, K; Hashizume, T; Sanada, M

    1995-01-01

    The mechanism of the enhanced activity of BO-2727 against imipenem-resistant Pseudomonas aeruginosa was studied by using a set of four isogenic strains derived from beta-lactamase-deficient P. aeruginosa PAO4089 (blaJ blaP). Complementation of the blaJ and blaP mutations conferred greater resistance to biapenem, panipenem, and imipenem than to BO-2727 and meropenem, most notably in the outer membrane protein D2-deficient strain. The higher levels of resistance to biapenem, panipenem, and imipenem can be explained by the slow but significant hydrolysis by beta-lactamase, whereas the reduced levels of resistance to BO-2727 and meropenem would be attributable to their stability in the presence of high levels of beta-lactamase and the fact that they cause only low induction of beta-lactamase. It is also noted that the activity of BO-2727 against the beta-lactamase-deficient strain was less affected by the loss of the D2 porin than was that of meropenem, indicating that BO-2727 in comparison with meropenem can overcome an intrinsic resistance caused by the loss of D2. Moreover, comparative in vitro resistance studies have shown that BO-2727 and meropenem selected fewer resistant cells than other carbapenems. In conclusion, BO-2727 exhibited improved activity against imipenem-resistant P. aeruginosa, probably because of its ability to overcome loss of the D2 porin and beta-lactamase hydrolysis. PMID:7793876

  12. Fourier Transform Infrared Emission Spectroscopy and AB Initio Study of Hbo and BO

    NASA Astrophysics Data System (ADS)

    Li, G.; Hargreaves, R. J.; Bernath, P. F.

    2010-06-01

    The Fourier-transform infrared emission spectra of HBO and BO were recorded using a Bruker IFS-125HR Fourier transform spectrometer. HBO molecules were synthesized using a high temperature tube furnace at 1450 °C. Our spectra of the HBO molecule in the 1200-4000 cm-1 region contain the v1 and v3 fundamental vibrational modes plus numerous hot bands. An accurate potential energy surface using the MRCI method with correlation consistent core-valence basis sets aug-cc-PCVnZ (n=3, 4, 5) is being calculated and a vibrational configuration interaction (VCI) calculation based on this surface will be performed to assist in the assignment of the HBO hot bands. BO molecules were produced by applying a DC discharge to the furnace containing HBO. Our spectrum of BO in the 1200-2100 cm-1 region contains the fundamental bands of both isotopic species, 11BO, 10BO, and one hot band of the main isotopologue 11BO. The fundamental band of 11BO contains 95 lines roughly equally distributed between the P and R branches. A combined least-squares fit with ground state microwave data was performed to determine the spectroscopic constants. Further results on this ongoing project will be presented.

  13. Luminescence and Site Occupancy of Eu2+ in Ba2 Ca(BO3)2

    NASA Astrophysics Data System (ADS)

    Li, Pan-Lai; Wang, Zhi-Jun; Yang, Zhi-Ping; Guo, Qing-Lin

    2011-01-01

    A green phosphor Ba2Ca(BO3)2:Eu2+ was synthesized by a high temperature solid-state reaction method under a reductive atmosphere. The luminescence and site occupancy of Eu2+ in Ba2Ca(BO3)2 are investigated. Ba2Ca(BO3)2:Eu2+ shows one green band (537 nm) under 400 nm near ultraviolet excitation which is suitable for UV LED. Ca2+ and Ba2+ ions in Ba2Ca(BO3)2 are replaced by Eu2+ ions, the Ba2Ca(BO3)2:Eu2+ shows a dissymmetrical emission band. The influence of Eu2+ doping concentrations on the emission intensity of Ba2Ca(BO3)2:Eu2+ is studied. It is found that the emission intensity is influenced by the Eu2+ concentration and reaches the maximum value at 2% Eu2+. According to the Dexter theory, the concentration quenching mechanisms of Eu2+ in Ba2Ca(BO3)2 are the d-dinteraction.

  14. The synthesis and crystal structures of the related series of aluminoborates: Co sub 2. 1 Al sub 0. 9 BO sub 55 , Ni sub 2 AlBO sub 5 , and Cu sub 2 AlBO sub 5

    SciTech Connect

    Hriljac, J.A.; Brown, R.D.; Cheetham, A.K. ); Satek, L.C. )

    1990-02-01

    We report on the growth of single crystals of Ni{sub 2}AlBO{sub 5}, Cu{sub 2}AlBO{sub 5}, and the mixed-valent Co{sub 2.1}Al{sub 0.9}BO{sub 5} from borax fluxes. All of these materials have been studied by single-crystal X-ray diffraction. The nickel and cobalt compounds are isostructural with the natural mineral ludwigite, while the copper compound is a monoclinically distorted variant of this structure. All three compounds show nonrandom disorder of the transition metal and aluminium atoms over four crystallographically distinct metal sites. We discuss the structural effects of this disorder and attempt to rationalize the observed occupancies on the basis of covalent and ionic forces. Ni{sub 2}AlBO{sub 5}: orthorhombic, a = 12.O13(1) {angstrom}, b = 9.111(1) {angstrom}, c = 2.942(1){angstrom}, space group Pbam, Z = 4, R = 4.07%. Co{sub 2.1}Al{sub 0.9}BO{sub 5}: orthorhombic, a = 12.010(2) {angstrom}, b = 9.197(2) {angstrom}, c = 2.993(1) {angstrom}, space group Pbam, Z = 4, R = 4.44%. Cu{sub 2}AlBO{sub 5}; monoclinic, a = 9.365(1) {angstrom}, b = 11.778(2) {angstrom}, c = 3.072(2) {angstrom}, {beta} = 97.71(2){degree}, space group P2{sub 1}/a, Z = 4, R = 4.59%.

  15. OpenACC programs of the Swendsen-Wang multi-cluster spin flip algorithm

    NASA Astrophysics Data System (ADS)

    Komura, Yukihiro

    2015-12-01

    We present sample OpenACC programs of the Swendsen-Wang multi-cluster spin flip algorithm. OpenACC is a directive-based programming model for accelerators without requiring modification to the underlying CPU code itself. In this paper, we deal with the classical spin models as with the sample CUDA programs (Komura and Okabe, 2014), that is, two-dimensional (2D) Ising model, three-dimensional (3D) Ising model, 2D Potts model, 3D Potts model, 2D XY model and 3D XY model. We explain the details of sample OpenACC programs and compare the performance of the present OpenACC implementations with that of the CUDA implementations for the 2D and 3D Ising models and the 2D and 3D XY models.

  16. Replica-exchange Wang-Landau simulations of the H0P lattice protein model

    NASA Astrophysics Data System (ADS)

    Shi, Guangjie; Wüst, Thomas; Li, Ying Wai; Landau, David P.

    The hydrophobic-polar (HP) lattice protein model has been the subject of intensive investigation in an effort to aid our understanding of protein folding. However, the high ground state degeneracies caused by its simplification stands in contrast to the generally unique native states of natural proteins. Here we proposed a simple modification, by introducing a new type of ``neutral'' monomer, 0, i.e. neither hydrophobic nor polar, thus rendering the model more realistic without increasing the difficulties of sampling significantly. With the replica exchange Wang-Landau (REWL) scheme we investigated several widely studied HP proteins and their H0P counterparts. Dramatic differences in both ground state and thermodynamic properties have been found. For example, the H0P version of Crambin shows more clear two-step folding and 3 order of magnitudes less ground state degeneracy than its HP counterpart. Supported by NSF.

  17. Thermodynamics and structural properties of a confined HP protein determined by Wang-Landau simulation

    SciTech Connect

    Pattanasiri, Busara; Li, Ying Wai; Landau, David P; Wuest, Thomas; Triampo, Wannapong

    2013-01-01

    We used Wang-Landau sampling with inventive Monte Carlo moves to study the influence of surface characteristics on physical behavior of a hydrophobic-polar (HP) lattice protein model confined between two attractive surfaces. Three types of surfaces, namely, surfaces that attract: (a) all monomers; (b) only P monomers; or (c) only H monomers, have been considered. After obtaining the densities of states, we then found the thermodynamic and structural quantities, such as specific heat, number of surface contacts, and number of hydrophobic interaction pairs. A few conformational transitions , e.g., debridging process and hydrophobic core formation, can be identified based on an analysis of these quantities. Depending on the surface types, these transitions take place at different temperatures, while the ground state configurations show structural variations. These scenarios are confirmed by snapshots of typical states of the systems.

  18. Nonequilibrium behaviors of the three-dimensional Heisenberg model in the Swendsen-Wang algorithm

    NASA Astrophysics Data System (ADS)

    Nonomura, Yoshihiko; Tomita, Yusuke

    2016-01-01

    Recently, it was shown [Y. Nonomura, J. Phys. Soc. Jpn. 83, 113001 (2014), 10.7566/JPSJ.83.113001] that the nonequilibrium critical relaxation of the two-dimensional (2D) Ising model from a perfectly ordered state in the Wolff algorithm is described by stretched-exponential decay, and a universal scaling scheme was found to connect nonequilibrium and equilibrium behaviors. In the present study we extend these findings to vector spin models, and the 3D Heisenberg model could be a typical example. To evaluate the critical temperature and critical exponents precisely using the above scaling scheme, we calculate nonequilibrium ordering from the perfectly disordered state in the Swendsen-Wang algorithm, and we find that the critical ordering process is described by stretched-exponential growth with a comparable exponent to that of the 3D X Y model. The critical exponents evaluated in the present study are consistent with those in previous studies.

  19. ``Binless Wang-Landau sampling'' - a multicanonical Monte Carlo algorithm without histograms

    NASA Astrophysics Data System (ADS)

    Li, Ying Wai; Eisenbach, Markus

    Inspired by the very successful Wang-Landau (WL) sampling, we innovated a multicanonical Monte Carlo algorithm to obtain the density of states (DOS) for physical systems with continuous state variables. Unlike the original WL scheme where the DOS is obtained as a numerical array of finite resolution, our algorithm assumes an analytical form for the DOS using a well chosen basis set, with coefficients determined iteratively similar to the WL approach. To avoid undesirable artificial errors caused by the discretization of state variables, we get rid of the use of a histogram for keeping track of the number of visits to energy levels, but store the visited states directly for the fitting of coefficients. This new algorithm has the advantage of producing an analytical expression for the DOS, while the original WL sampling can be readily recovered. This research was supported by the Office of Science of the Department of Energy under Contract DE-AC05-00OR22725.

  20. [Spectra characteristics of LiM (M = Ca, Sr, Ba) BO3 : Tb3+ phosphor].

    PubMed

    Wang, Zhi-Jun; Li, Pan-Lai; Yang, Zhi-Ping; Guo, Qing-Lin

    2009-11-01

    LiM (M = Ca, Sr, Ba) BO3 : Tb3+ phosphors were synthesized by solid state reaction. The starting materials CaCO3, SrCO3, BaCO3, H3 BO3, Li2 CO3, Na2 CO3, K2 CO3 and Tb4 O7 (99.99% in mass) in appropriate stoichiometric ratio were mixed in the alumina crucible, then the mixed powders were calcined at 700 degrees C for 2 h, and LiCaBO3 : Tb3+, LiSrBO3 : Tb3+ and LiB-aBO3 : Tb3+ phosphors were obtained. The emission and excitation spectra were measured by a Shimadzu RF-540 ultraviolet spectrophotometer. All the photoluminescence properties of these phosphors were measured at room temperature. The emission spectra of LiM (M = Ca, Sr, Ba) BO3 : Tb3+ phosphors show several bands, and the main emission peaks correspond to the 5D4 --> 7F6(486, 486, 488 nm), 5D4 --> F5 (544, 544, 544 nm), 5D4 --> 7F4 (590, 595, 593 nm) and 5D4 --> 7F3 (620, 620, 616 nm) typical transitions of Tb3+, and the typical transitions of Tb3+ happens to split because of the effects of LiM (M = Ca, Sr, Ba) BO3 crystals field. The excitation spectra for the 544 nm green emission of LiM (M = Ca, Sr, Ba)BO3 : Tb3+ phosphors illuminate that these kinds of phosphors can be effectively excited by ultraviolet (350-410 nm) light, and emit green light, therefore, they are promising phosphors for white light emitting diodes. Effects of activation and charge compensation on the luminescence intensities of LiM (M = Ca, Sr, Ba) BO3 : Tb3+ phosphors were studied, and the results show that the intensities were obviously effected. PMID:20101952

  1. Genetic variation in BoLA microsatellite loci in Portuguese cattle breeds.

    PubMed

    Bastos-Silveira, C; Luís, C; Ginja, C; Gama, L T; Oom, M M

    2009-02-01

    Major histocompatibility complex (MHC) typing based on microsatellites can be a valuable approach to understanding the selective processes occurring at linked or physically close MHC genes and can provide important information on variability and relationships of populations. Using microsatellites within or in close proximity with bovine lymphocyte antigen (BoLA) genes, we investigated the polymorphisms in the bovine MHC, known as the BoLA, in eight Portuguese cattle breeds. Additional data from non-BoLA microsatellite loci were also used to compare the variability between these regions. Diversity was higher in BoLA than in non-BoLA microsatellites, as could be observed by the number of alleles, allelic richness and observed heterozygosity. Brava de Lide, a breed selected for aggressiveness and nobility, presented the lowest values of observed heterozygosity and allelic richness in both markers. Results from neutrality tests showed few statistically significant differences between the observed Hardy-Weinberg homozygosity (F) and the expected homozygosity (F(E)), indicating the apparent neutrality of the BoLA microsatellites within the analysed breeds. Nevertheless, we detected a trend of lower values of observed homozygosity compared with the expected one. We also detected some differences in the levels of allelic variability among the four BoLA microsatellites. Our data showed a higher number of alleles at the BoLA-DRB3 locus than at the BoLA-DRBP1 locus. These differences could be related to their physical position in the chromosome and may reflect functional requirements for diversity. PMID:18945294

  2. Search for compounds of the NaBaR(BO{sub 3}){sub 2} family (R = La, Nd, Gd, and Yb) and the new NaBaYb(BO{sub 3}){sub 2} orthoborate

    SciTech Connect

    Svetlyakova, T. N. Kokh, A. E.; Kononova, N. G.; Fedorov, P. P.; Rashchenko, S. V.; Maillard, A.

    2013-01-15

    A search for compounds of the NaBaR(BO{sub 3}){sub 2} composition (where R = La{sup 3+}, Nd{sup 3+}, Gd{sup 3+}, or Yb{sup 3+}) is performed by solid state synthesis and spontaneous crystallization. A new compound, NaBaYb(BO{sub 3}){sub 2}, is found in this series. It crystallizes in space group R3{sup -} and belongs to the family of sublayer complex orthoborates with isolated BO{sub 3} groups NaBaR(BO{sub 3}){sub 2} (R = Y, Sc, and Yb). Theoretical X-ray powder diffraction patterns of NaBaY(BO{sub 3}){sub 2}, NaBaSc(BO{sub 3}){sub 2}, and NaBaYb(BO{sub 3}){sub 2} are calculated based on single-crystal data.

  3. A new rubidium beryllium borate, RbBe4(BO3)3.

    PubMed

    Wen, Xiao-Hong; Li, R-K; Chen, C-T

    2006-03-01

    Single crystals of a new rubidium beryllium borate, RbBe4(BO3)3, have been obtained by spontaneous nucleation from a high-temperature melt. This new orthorhombic (Pnma) structure type contains [Be2BO4]- rings, made of two BeO4 tetrahedra and one BO3 triangle, which constitute the basic structural units. The m plane runs through the B and one of the O atoms and intersects the ring. These rings form chains in the a direction, which are connected in the b and c directions to form zeolite-type cages in which the Rb+ cations are located, at sites of m symmetry. PMID:16518029

  4. Pi and sigma double conjugations in boronyl polyboroene nanoribbons: B(n)(BO)2- and B(n)(BO)2 (n = 5-12).

    PubMed

    Zhai, Hua-Jin; Chen, Qiang; Bai, Hui; Lu, Hai-Gang; Li, Wei-Li; Li, Si-Dian; Wang, Lai-Sheng

    2013-11-01

    A series of boron dioxide clusters, B(x)O2(-) (x = 7-14), have been produced and investigated using photoelectron spectroscopy and quantum chemical calculations. The dioxide clusters are shown to possess elongated ladder-like structures with two terminal boronyl (BO) groups, forming an extensive series of boron nanoribbons, B(n)(BO)2(-) (n = 5-12). The electron affinities of B(n)(BO)2 exhibit a 4n periodicity, indicating that the rhombic B4 unit is the fundamental building block in the nanoribbons. Both π and σ conjugations are found to be important in the unique bonding patterns of the boron nanoribbons. The π conjugation in these clusters is analogous to the polyenes (aka polyboroenes), while the σ conjugation plays an equally important role in rendering the stability of the nanoribbons. The concept of σ conjugation established here has no analogues in hydrocarbons. Calculations suggest the viability of even larger boronyl polyboroenes, B16(BO)2 and B20(BO)2, extending the boron nanoribbons to ~1.5 nm in length or possibly even longer. The nanoribbons form a new class of nanowires and may serve as precursors for a variety of boron nanostructures. PMID:24206292

  5. The spatial and temporal expression of Ch-en, the engrailed gene in the polychaete Chaetopterus, does not support a role in body axis segmentation

    NASA Technical Reports Server (NTRS)

    Seaver, E. C.; Paulson, D. A.; Irvine, S. Q.; Martindale, M. Q.

    2001-01-01

    We are interested in understanding whether the annelids and arthropods shared a common segmented ancestor and have approached this question by characterizing the expression pattern of the segment polarity gene engrailed (en) in a basal annelid, the polychaete Chaetopterus. We have isolated an en gene, Ch-en, from a Chaetopterus cDNA library. Genomic Southern blotting suggests that this is the only en class gene in this animal. The predicted protein sequence of the 1.2-kb cDNA clone contains all five domains characteristic of en proteins in other taxa, including the en class homeobox. Whole-mount in situ hybridization reveals that Ch-en is expressed throughout larval life in a complex spatial and temporal pattern. The Ch-en transcript is initially detected in a small number of neurons associated with the apical organ and in the posterior portion of the prototrochophore. At later stages, Ch-en is expressed in distinct patterns in the three segmented body regions (A, B, and C) of Chaetopterus. In all segments, Ch-en is expressed in a small set of segmentally iterated cells in the CNS. In the A region, Ch-en is also expressed in a small group of mesodermal cells at the base of the chaetal sacs. In the B region, Ch-en is initially expressed broadly in the mesoderm that then resolves into one band/segment coincident with morphological segmentation. The mesodermal expression in the B region is located in the anterior region of each segment, as defined by the position of ganglia in the ventral nerve cord, and is involved in the morphogenesis of segment-specific feeding structures late in larval life. We observe banded mesodermal and ectodermal staining in an anterior-posterior sequence in the C region. We do not observe a segment polarity pattern of expression of Ch-en in the ectoderm, as is observed in arthropods. Copyright 2001 Academic Press.

  6. Two new cave-dwelling species of the millipede genus Paracortina Wang & Zhang, 1993 from southern China (Diplopoda, Callipodida, Paracortinidae)

    PubMed Central

    Liu, Weixin; Tian, Mingyi

    2015-01-01

    Abstract Two new species of the millipede genus Paracortina Wang & Zhang, 1993 are described. Both are presumed troglophiles: Paracortina zhangi sp. n. from a cave in Ceheng County, southwestern Guizhou Province and Paracortina yinae sp. n. from a cave in Longlin County, western Guangxi Zhuang Autonomous Region. A distribution map and a key to all 12 Paracortina species are also provided. PMID:26312031

  7. On the Status of Women in Seventeenth-Century China: Teaching Spence's "The Death of Woman Wang."

    ERIC Educational Resources Information Center

    Gao, James Z.

    1998-01-01

    Describes the application of Frederick Drake and Denee Corbin's method of "dramatization in the classroom" to teaching Chinese history. Outlines the use of the book, "The Death of Woman Wang," to study 17th-century Chinese social life and laws. Includes an outline of activities for the preparation and teaching of the lesson. (DSK)

  8. Why Three Heads Are a Better Bet than Four: A Reply to Sun, Tweney, and Wang (2010)

    ERIC Educational Resources Information Center

    Hahn, Ulrike; Warren, Paul A.

    2010-01-01

    We (Hahn & Warren, 2009) recently proposed a new account of the systematic errors and biases that appear to be present in people's perception of randomly generated events. In a comment on that article, Sun, Tweney, and Wang (2010) critiqued our treatment of the gambler's fallacy. We had argued that this fallacy was less gross an error than it…

  9. Bridge No. 1363, First B&O Crossing, detail of skewed through ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Bridge No. 1363, First B&O Crossing, detail of skewed through truss, looking west. - Western Maryland Railway, Cumberland Extension, Pearre to North Branch, from WM milepost 125 to 160, Pearre, Washington County, MD

  10. Skewed west portal of Bridge No. 1363, First B&O Crossing, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Skewed west portal of Bridge No. 1363, First B&O Crossing, looking east. - Western Maryland Railway, Cumberland Extension, Pearre to North Branch, from WM milepost 125 to 160, Pearre, Washington County, MD

  11. A vibrational spectroscopic study of the borate mineral takedaite Ca3(BO3)2

    NASA Astrophysics Data System (ADS)

    Frost, Ray L.; López, Andrés; Xi, Yunfei; Graça, Leonardo M.; Scholz, Ricardo

    2014-11-01

    We have studied the mineral takedaite Ca3(BO3)2, a borate mineral of calcium using SEM with EDX and vibrational spectroscopy. Chemical analysis shows a homogeneous phase, composed of Ca. Boron was not detected. A very intense Raman band at 1087 cm-1 is assigned to the BO stretching vibration of BO3 units. Additional Raman bands may be due to isotopic splitting. In the infrared spectrum, bands at 1218 cm-1 and at 1163, 1262 and 1295 cm-1 are assigned to the trigonal borate stretching modes. Raman bands at 712 and 715 cm-1 are assigned to the in-plane bending modes of the BO3 units. Vibrational spectroscopy enables aspects of the molecular structure of takedaite to be assessed.

  12. Brookland Site Development Study, Brookland, bounded by B&O Railroad Tracks, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Brookland Site Development Study, Brookland, bounded by B&O Railroad Tracks, Rhode Island & Brentwood Avenues on the south, 18th Street & South Dakota Avenue on the east, and Michigan Avenue on the North, Washington, District of Columbia, DC

  13. 48. Quincy, MA, BO37, Launch Area, Underground Missile Storage Structure, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    48. Quincy, MA, BO-37, Launch Area, Underground Missile Storage Structure, interior detail of water and hydraulic pumps VIEW WEST - NIKE Missile Battery PR-79, Launch Area, East Windsor Road south of State Route 101, Foster, Providence County, RI

  14. Charge Transfer Salts of BO with Paramagnetic Isothiocyanato Complex Anions: (BO)[ M(isoq) 2(NCS) 4]; M=Cr III or Fe III, isoq=isoquinoline and BO=Bis(ethylenedioxo)tetrathiafulvalene

    NASA Astrophysics Data System (ADS)

    Setifi, Fatima; Ota, Akira; Ouahab, Lahcéne; Golhen, Stèphane; Yamochi, Hideki; Saito, Gunzi

    2002-11-01

    The preparation, X-ray structures and magnetic properties of two isostructural new charge transfer salts: (BO)[ M(isoq) 2(NCS) 4]; M=Cr III(1), Fe III(2) and isoq=isoquinoline are reported. Their structure consists of alternate organic and inorganic layers, each layer being formed by mixed columns of BO radical cations and paramagnetic metal complex anions. There are short intermolecular contacts between donor and anion (S2 anion· · ·S4 BO<3.5 Å) and between adjacent BO molecules (O· · · O1<3.2 Å). The two compounds are insulators. ESR measurements show single signal without separating the donor and anion spins. The magnetic measurements obey the Curie-Weiss law and revealed dominant antiferromagnetic interactions between anion spin and donor spin, but long-range magnetic ordering did not occur down to 2 K. This is directly related to structural reasons which were deduced from a comparison of the title compounds with other 1:1 salts containing same anion complexes and different donors.

  15. In situ high pressure investigations on metastable BiBO3

    NASA Astrophysics Data System (ADS)

    Khanna, Atul; Mishra, A. K.; Sharma, S. M.

    2016-05-01

    Synchrotron based angle dispersive x-ray diffraction (ADXRD) studies were performed on metastable crystalline bismuth orthoborate (BiBO3) up to 14.5 GPa during compression and decompression cycle. These studies revealed that the BiBO3 is unstable and it converts to Bi4B2O9 phase at high pressure. Moreover the transformation is found to be irreversible.

  16. In vitro and in vivo antibacterial activities of BO-2727, a new carbapenem.

    PubMed Central

    Asahi, Y; Miyazaki, S; Yamaguchi, K

    1995-01-01

    BO-2727, a new injectable carbapenem, was evaluated for its in vitro and in vivo antibacterial activities in comparison with those of biapenem, meropenem, imipenem, cefpirome, and ceftazidime. BO-2727 had activity comparable to that of imipenem against methicillin-susceptible staphylococci and streptococci, with MICs at which 90% of strains tested (MIC90s) are inhibited being equal to 0.5 microgram/ml or less. Against methicillin-resistant staphylococci, BO-2727 was the most active among the antibiotics tested, with MIC90s ranging from 4 to 8 micrograms/ml. BO-2727 was highly active against members of the family Enterobacteriaceae, Haemophilus influenzae, and Moraxella catarrhalis, with MIC90s ranging from 0.006 to 2 micrograms/ml. BO-2727 was also highly active against Pseudomonas aeruginosa (imipenem-susceptible strains), for which the MIC90 was 2 micrograms/ml, which was lower than those of imipenem, cefpirome, and ceftazidime and comparable to those of biapenem and meropenem. Differences in activity between BO-2727 and the other carbapenems against imipenem-resistant P. aeruginosa were particularly striking (MIC90, 8 micrograms/ml). Furthermore, BO-2727 displayed a high degree of activity against many of the ceftazidime-, ciprofloxacin-, and/or gentamicin-resistant isolates of P. aeruginosa. The in vivo efficacy of BO-2727 against experimental septicemia caused by gram-positive and gram-negative bacteria, including methicillin-resistant Staphylococcus aureus and imipenem-resistant P. aeruginosa, reflected its potent in vitro activity and high levels in plasma. PMID:7625784

  17. Lead zinc borate, PbZn2(BO3)2.

    PubMed

    Chen, Xue An; Zhao, Ying Hua; Chang, Xin An; Zhang, Li; Xue, Hai Ping

    2006-01-01

    PbZn2(BO3)2 crystallizes in the space group Pccn, with the Pb cation at a site with imposed twofold symmetry. The compound represents a new structure type in which ZnBO3 layers are bridged by Pb2+ cations, giving rise to a three-dimensional framework. Channels parallel to the [010] direction accommodate the stereochemically active lone pairs of the Pb2+ cations. PMID:16397327

  18. In vitro and in vivo antibacterial activities of BO-1341, a new antipseudomonal cephalosporin.

    PubMed Central

    Nakagawa, S; Sanada, M; Matsuda, K; Hashizume, T; Asahi, Y; Ushijima, R; Ohtake, N; Tanaka, N

    1989-01-01

    BO-1341, a new antipseudomonal semisynthetic cephalosporin, was evaluated for in vitro and in vivo antibacterial activities in comparison with ceftazidime, cefotaxime, and cefoperazone. The in vitro activity of BO-1341 was generally superior or comparable to the activities of the reference antibiotics against clinical isolates of the family Enterobacteriaceae. BO-1341 was highly active against Pseudomonas aeruginosa (MIC for 90% of the strains tested, 1.56 micrograms/ml), Pseudomonas maltophilia (MIC for 50% of the strains tested, 1.56 micrograms/ml), and Acinetobacter calcoaceticus (MIC for 90% of the strains tested, 3.13 micrograms/ml). Furthermore, BO-1341 was highly active against P. aeruginosa isolates resistant to the other antibiotics. Of 199 P. aeruginosa isolates tested, only 2 were resistant to BO-1341. These two strains were also resistant to ceftazidime, cefotaxime, and cefoperazone. Haemophilus influenzae, Branhamella catarrhalis, and nonenteric streptococci were also susceptible to BO-1341, but Staphylococcus aureus, Streptococcus faecalis, and Bacteroides fragilis were not susceptible to the compound. The protective efficacy against experimental infections in mice caused by nine strains of gram-negative bacteria, including P. aeruginosa, reflected the potent in vitro activity. PMID:2510590

  19. Be2BO3F: A Phase of Beryllium Fluoride Borate Derived from KBe2BO3F2 with Short UV Absorption Edge.

    PubMed

    Guo, Shu; Liu, Lijuan; Xia, Mingjun; Kang, Lei; Huang, Qian; Li, Chao; Wang, Xiaoyang; Lin, Zheshuai; Chen, Chuangtian

    2016-07-01

    A phase of beryllium fluoride borate Be2BO3F (BBF) was successfully developed and grown by spontaneous nucleation from high temperature solution. The crystal belongs to the trigonal space group of R3̅c (No. 167), with lattice parameters a = 4.442(1) Å, c = 24.956(5) Å, and Z = 2. It is constructed by the infinite planar [Be2BO3F2]∞ layers, in which the planar triangle [BO3](3-) and the tetrahedral [BeO3F](5-) anionic groups are arranged in parallel via corner-sharing O atoms in each ab plane. BBF is an incongruent compound and decomposes at about 650 °C. The deep-ultraviolet (DUV) transmittance spectrum reveals that its UV cutoff wavelength is down to ∼150 nm. Theoretical calculations show that BBF has a large birefringence (Δn = 0.13 at 200 nm), which mainly originates from the infinite planar [Be2BO3F2]∞ layers. In conclusion, BBF may be served as a potential DUV birefringent material. PMID:27332696

  20. Nonconvergence of the Wang-Landau algorithms with multiple random walkers

    NASA Astrophysics Data System (ADS)

    Belardinelli, R. E.; Pereyra, V. D.

    2016-05-01

    This paper discusses some convergence properties in the entropic sampling Monte Carlo methods with multiple random walkers, particularly in the Wang-Landau (WL) and 1 /t algorithms. The classical algorithms are modified by the use of m -independent random walkers in the energy landscape to calculate the density of states (DOS). The Ising model is used to show the convergence properties in the calculation of the DOS, as well as the critical temperature, while the calculation of the number π by multiple dimensional integration is used in the continuum approximation. In each case, the error is obtained separately for each walker at a fixed time, t ; then, the average over m walkers is performed. It is observed that the error goes as 1 /√{m } . However, if the number of walkers increases above a certain critical value m >mx , the error reaches a constant value (i.e., it saturates). This occurs for both algorithms; however, it is shown that for a given system, the 1 /t algorithm is more efficient and accurate than the similar version of the WL algorithm. It follows that it makes no sense to increase the number of walkers above a critical value mx, since it does not reduce the error in the calculation. Therefore, the number of walkers does not guarantee convergence.

  1. Wang-Landau sampling of the interplay between surface adsorption and folding of HP lattice proteins

    SciTech Connect

    Li, Ying Wai; Wuest, Thomas; Landau, David P

    2014-01-01

    Generic features associated with the adsorption of proteins on solid surfaces are reviewed within the framework of the hydrophobic-polar (HP) lattice protein model. The thermodynamic behavior and structural properties of various HP protein sequences interacting with attractive surfaces have been studied using extensive Wang-Landau sampling with different types of surfaces, each of which attracts either: all monomers, only hydrophobic (H) monomers, or only polar (P) monomers, respectively. Consequently, different types of folding behavior occur for varied surface strengths. Analysis of the combined patterns of various structural observables, e.g., the derivatives of the numbers of interaction contacts, together with the specific heat, leads to the identification of fundamental categories of folding and transition hierarchies. We also inferred a connection between the transition categories and the relative surface strengths, i.e., the ratios of the surface attractive strengths to the intra-chain attraction among H monomers. We thus believe that the folding hierarchies and identification scheme are generic for different HP sequences interacting with attractive surfaces, regardless of the chain length, sequence, or surface attraction.

  2. Somatic embryogenesis and enhanced shoot organogenesis in Metabriggsia ovalifolia W. T. Wang.

    PubMed

    Ouyang, Yao; Chen, Yulu; Lü, Jinfeng; Teixeira da Silva, Jaime A; Zhang, Xinhua; Ma, Guohua

    2016-01-01

    An efficient protocol providing a dual regeneration pathway via direct shoot organogenesis and somatic embryogenesis for an endangered species, Metabriggsia ovalifolia W. T. Wang, was established from leaf explants. When applied at 2.5 μM, the cytokinins 6-benzyladenine (BA) or thidiazuron (TDZ) and the auxins indole-3-butyric acid (IBA), α-naphthaleneacetic acid (NAA) and indole-3-acetic acid (IAA) could induce shoots when on basal Murashige and Skoog (MS) medium. BA and TDZ could induce more adventitious shoots (19.1 and 31.2/explant, respectively) than NAA (4.6/explant), IBA (5.7/explant) or IAA (6.4/explant). BA and TDZ at 5-10 μM could induce both shoots and somatic embryos. A higher concentration of TDZ (25 μM) induced only somatic embryos (39.8/explant). The same concentration of BA induced both adventitious shoots (23.6/explant) and somatic embryos (9.7/explant). Thus, somatic embryogenesis in this plant needs a high cytokinin concentration (BA; TDZ), as evidenced by histology. Somatic embryos germinated easily when left on the same media, but formed adventitious roots in two weeks on MS supplemented with 0.5 μM NAA, 0.5 μM IBA and 0.1% activated charcoal. Over 93% of plantlets survived following acclimatization and transfer to a mixture of sand and vermiculite (1:1, v/v) in trays. PMID:27090564

  3. Somatic embryogenesis and enhanced shoot organogenesis in Metabriggsia ovalifolia W. T. Wang

    PubMed Central

    Ouyang, Yao; Chen, Yulu; Lü, Jinfeng; Teixeira da Silva, Jaime A.; Zhang, Xinhua; Ma, Guohua

    2016-01-01

    An efficient protocol providing a dual regeneration pathway via direct shoot organogenesis and somatic embryogenesis for an endangered species, Metabriggsia ovalifolia W. T. Wang, was established from leaf explants. When applied at 2.5 μM, the cytokinins 6-benzyladenine (BA) or thidiazuron (TDZ) and the auxins indole-3-butyric acid (IBA), α-naphthaleneacetic acid (NAA) and indole-3-acetic acid (IAA) could induce shoots when on basal Murashige and Skoog (MS) medium. BA and TDZ could induce more adventitious shoots (19.1 and 31.2/explant, respectively) than NAA (4.6/explant), IBA (5.7/explant) or IAA (6.4/explant). BA and TDZ at 5–10 μM could induce both shoots and somatic embryos. A higher concentration of TDZ (25 μM) induced only somatic embryos (39.8/explant). The same concentration of BA induced both adventitious shoots (23.6/explant) and somatic embryos (9.7/explant). Thus, somatic embryogenesis in this plant needs a high cytokinin concentration (BA; TDZ), as evidenced by histology. Somatic embryos germinated easily when left on the same media, but formed adventitious roots in two weeks on MS supplemented with 0.5 μM NAA, 0.5 μM IBA and 0.1% activated charcoal. Over 93% of plantlets survived following acclimatization and transfer to a mixture of sand and vermiculite (1:1, v/v) in trays. PMID:27090564

  4. Enhanced von Weizsäcker Wang-Govind-Carter kinetic energy density functional for semiconductors

    NASA Astrophysics Data System (ADS)

    Shin, Ilgyou; Carter, Emily A.

    2014-05-01

    We propose a new form of orbital-free (OF) kinetic energy density functional (KEDF) for semiconductors that is based on the Wang-Govind-Carter (WGC99) nonlocal KEDF. We enhance within the latter the semi-local von Weizsäcker KEDF term, which is exact for a single orbital. The enhancement factor we introduce is related to the extent to which the electron density is localized. The accuracy of the new KEDF is benchmarked against Kohn-Sham density functional theory (KSDFT) by comparing predicted energy differences between phases, equilibrium volumes, and bulk moduli for various semiconductors, along with metal-insulator phase transition pressures. We also compare point defect and (100) surface energies in silicon for a broad test of its applicability. This new KEDF accurately reproduces the exact non-interacting kinetic energy of KSDFT with only one additional adjustable parameter beyond the three parameters in the WGC99 KEDF; it exhibits good transferability between semiconducting to metallic silicon phases and between various III-V semiconductors without parameter adjustment. Overall, this KEDF is more accurate than previously proposed OF KEDFs (e.g., the Huang-Carter (HC) KEDF) for semiconductors, while the computational efficiency remains at the level of the WGC99 KEDF (several hundred times faster than the HC KEDF). This accurate, fast, and transferable new KEDF holds considerable promise for large-scale OFDFT simulations of metallic through semiconducting materials.

  5. Efficient generation of peptide hydrazides via direct hydrazinolysis of Peptidyl-Wang-TentaGel resins.

    PubMed

    Bello, Claudia; Kikul, Frauke; Becker, Christian F W

    2015-03-01

    Peptide hydrazides are valuable building blocks in peptide and protein chemistry, e.g. as precursors of peptide thioesters that allow the preparation of these important intermediates under mild conditions. Additional robust and versatile methods for the generation of peptide hydrazides from standard solid supports are therefore highly desired in order to facilitate access to peptide thioester via Fmoc-based SPPS. Here, the efficient generation of peptide hydrazides from conventional 4-hydroxymethyl phenol Wang-TentalGel peptidyl resins is described. Direct hydrazinolysis of a 19mer mucin1 peptide gives the protected peptide hydrazide in excellent yields. Testing a series of octapeptides carrying the 20 common proteinogenic amino acids at their C-terminus led to preparation of all corresponding peptide hydrazides in very good to excellent yields and purities. The available set of octapeptides allowed analyzing the influence of the nature of the C-terminal amino acid and of the solvent on the hydrazinolysis reaction. Furthermore, the compatibility of the method with posttranslational modifications (here glycosylation) and with potentially sensitive functional groups in amino acid side chains makes this approach a viable alternative for obtaining peptide hydrazides. It combines the advantages of a straightforward synthesis with stereochemical stability and flexibility, as it provides easy access to the peptide acid and the peptide thioester (via the hydrazide) from the same solid support. PMID:25648984

  6. Applications of Wang-Landau sampling to determine phase equilibria in complex fluids

    NASA Astrophysics Data System (ADS)

    Ganzenmüller, Georg; Camp, Philip J.

    2007-10-01

    Applications of the Wang-Landau algorithm for simulating phase coexistence at fixed temperature are presented. The number density is sampled using either volume scaling or particle insertion/deletion. The resulting algorithms, while being conceptually easy, are of comparable efficiency to existing multicanonical methods but with the advantage that neither the chemical potential nor the pressure at phase coexistence has to be estimated in advance of the simulation. First, we benchmark the algorithm against literature results for the vapor-liquid transition in the Lennard-Jones fluid. We then demonstrate the general applicability of the algorithm by studying vapor-liquid coexistence in two examples of complex fluids: charged soft spheres, which exhibit a transition similar to that in the restricted primitive model of ionic fluids, being characterized by strong ion pairing in the vapor phase; and Stockmayer fluids with high dipole strengths, in which the constituent particles aggregate to form chains, and for which the very existence of a transition has been widely debated. Finally, we show that the algorithm can be used to locate a weak isotropic-nematic transition in a fluid of Gay-Berne mesogens.

  7. Applications of Wang-Landau sampling to determine phase equilibria in complex fluids.

    PubMed

    Ganzenmüller, Georg; Camp, Philip J

    2007-10-21

    Applications of the Wang-Landau algorithm for simulating phase coexistence at fixed temperature are presented. The number density is sampled using either volume scaling or particle insertion/deletion. The resulting algorithms, while being conceptually easy, are of comparable efficiency to existing multicanonical methods but with the advantage that neither the chemical potential nor the pressure at phase coexistence has to be estimated in advance of the simulation. First, we benchmark the algorithm against literature results for the vapor-liquid transition in the Lennard-Jones fluid. We then demonstrate the general applicability of the algorithm by studying vapor-liquid coexistence in two examples of complex fluids: charged soft spheres, which exhibit a transition similar to that in the restricted primitive model of ionic fluids, being characterized by strong ion pairing in the vapor phase; and Stockmayer fluids with high dipole strengths, in which the constituent particles aggregate to form chains, and for which the very existence of a transition has been widely debated. Finally, we show that the algorithm can be used to locate a weak isotropic-nematic transition in a fluid of Gay-Berne mesogens. PMID:17949170

  8. Validation of Community Models: 2. Development of a Baseline, Using the Wang-Sheeley-Arge Model

    NASA Technical Reports Server (NTRS)

    MacNeice, Peter

    2009-01-01

    This paper is the second in a series providing independent validation of community models of the outer corona and inner heliosphere. Here I present a comprehensive validation of the Wang-Sheeley-Arge (WSA) model. These results will serve as a baseline against which to compare the next generation of comparable forecasting models. The WSA model is used by a number of agencies to predict Solar wind conditions at Earth up to 4 days into the future. Given its importance to both the research and forecasting communities, it is essential that its performance be measured systematically and independently. I offer just such an independent and systematic validation. I report skill scores for the model's predictions of wind speed and interplanetary magnetic field (IMF) polarity for a large set of Carrington rotations. The model was run in all its routinely used configurations. It ingests synoptic line of sight magnetograms. For this study I generated model results for monthly magnetograms from multiple observatories, spanning the Carrington rotation range from 1650 to 2074. I compare the influence of the different magnetogram sources and performance at quiet and active times. I also consider the ability of the WSA model to forecast both sharp transitions in wind speed from slow to fast wind and reversals in the polarity of the radial component of the IMF. These results will serve as a baseline against which to compare future versions of the model as well as the current and future generation of magnetohydrodynamic models under development for forecasting use.

  9. Generic transition hierarchies of lattice HP protein adsorption: A Wang-Landau study

    NASA Astrophysics Data System (ADS)

    Li, Ying Wai; Landau, D. P.; Wüst, T.

    2012-02-01

    We have applied Wang-Landau sampling with appropriate trial movesootnotetextT. W"ust and D. P. Landau, Phy. Rev. Lett. 102, 178101 (2009). to investigate the thermodynamics and structural properties of the HP lattice protein modelootnotetextK. A. Dill, Biochemistry 24, 1501 (1985). interacting with an attractive substrate. The conformational ``phase transitions'' of several benchmark HP sequences have been identified by a comprehensive canonical analysis of the specific heat and structural observables, e. g. radius of gyration and thermal derivatives of number of surface contacts. Three major ``transitions'': adsorption, hydrophobic core formation, and ``flattening'' of adsorbed structures, are observed. Depending on the surface attractive strength relative to the intra-protein attraction among the H monomers, these processes take place in a different order upon cooling. We identify a small number of generic categories that are sufficient to classify the folding hierarchies for different HP chains consisting of assorted sequences and chain lengths, regardless of the monomer type that the surface attracts. We thus believe that this classification scheme is generally applicable to lattice protein adsorption problems.

  10. Temperature-dependent phase transition of ferroelectric perovskites: A Wang-Landau-DFT approach

    NASA Astrophysics Data System (ADS)

    Yuk, Simuck; Li, Ying Wai; Eisenbach, Markus; Cooper, Valentino

    Since the discovery of ferroelectricity in perovskite oxides, considerable efforts have been devoted to understanding their phase transition behaviors in terms of temperature, pressure, and composition. Such materials have regularly been used in transducer and actuator applications. As our first step to make accurate predictions of the crystal phases of more complex oxides such as Pb(ZrxTi1-x) O3, we have used the Wang-Landau (WL) algorithm and density functional theory (DFT) to examine the temperature-dependent phase transition of PbTiO3, BaTiO3, and KNbO3. DFT was employed to evaluate the energetics of important crystal-structure candidates, which were later used as the input for WL algorithm. In addition, we examine how the choice of exchange-correlation functionals affects our predictions of the relevant phase transition temperatures. Research supported by the U.S. Department of Energy, Office of Science, Basic Energy Sciences, Materials Science and Engineering Division and the Office of Science Early Career Research Program (V.R.C.) and used resources at NERSC and OLCF.

  11. Enhanced von Weizsäcker Wang-Govind-Carter kinetic energy density functional for semiconductors

    SciTech Connect

    Shin, Ilgyou; Carter, Emily A.

    2014-05-14

    We propose a new form of orbital-free (OF) kinetic energy density functional (KEDF) for semiconductors that is based on the Wang-Govind-Carter (WGC99) nonlocal KEDF. We enhance within the latter the semi-local von Weizsäcker KEDF term, which is exact for a single orbital. The enhancement factor we introduce is related to the extent to which the electron density is localized. The accuracy of the new KEDF is benchmarked against Kohn-Sham density functional theory (KSDFT) by comparing predicted energy differences between phases, equilibrium volumes, and bulk moduli for various semiconductors, along with metal-insulator phase transition pressures. We also compare point defect and (100) surface energies in silicon for a broad test of its applicability. This new KEDF accurately reproduces the exact non-interacting kinetic energy of KSDFT with only one additional adjustable parameter beyond the three parameters in the WGC99 KEDF; it exhibits good transferability between semiconducting to metallic silicon phases and between various III-V semiconductors without parameter adjustment. Overall, this KEDF is more accurate than previously proposed OF KEDFs (e.g., the Huang-Carter (HC) KEDF) for semiconductors, while the computational efficiency remains at the level of the WGC99 KEDF (several hundred times faster than the HC KEDF). This accurate, fast, and transferable new KEDF holds considerable promise for large-scale OFDFT simulations of metallic through semiconducting materials.

  12. Phase transition of a single star polymer: A Wang-Landau sampling study

    NASA Astrophysics Data System (ADS)

    Wang, Zilu; He, Xuehao

    2011-09-01

    Star polymers, as an important class of nonlinear macromolecules, process special thermodynamic properties for the existence of a common connecting point. The thermodynamic transitions of a single star polymer are systematically studied with the bond fluctuation model using Wang-Landau sampling techniques. A new analysis method employing the shape factor is proposed to locate the coil-globule (CG) and liquid-crystal (LC) transitions, which shows a higher efficiency and accuracy than the canonical specific heat function. The LC transition temperature is found to obey the identical scaling law as the linear polymers. However, the CG transition temperature shifts towards the LC transition with the increasing of the arm number. The reason is that for the star polymer a lower temperature is needed for the attractive force to overcome the excluded volume effect of the polymer chain because of its high arm density. This work clearly proves the structural distinction of the linear and star polymers can only affect the CG transition while has no influence on the LC transition.

  13. Structure, composition, and assembly of paracrystalline phycobiliproteins in Synechocystis sp. strain BO 8402 and of phycobilisomes in the derivative strain BO 9201.

    PubMed Central

    Reuter, W; Westermann, M; Brass, S; Ernst, A; Böger, P; Wehrmeyer, W

    1994-01-01

    The phycobiliproteins of the unicellular cyanobacterium Synechocystis sp. strain BO 8402 and its derivative strain BO 9201 are compared. The biliproteins of strain BO 8402 are organized in paracrystalline inclusion bodies showing an intense autofluorescence in vivo. These protein-pigment aggregates have been isolated. The highly purified complexes contain phycocyanin with traces of phycoerythrin, corresponding linker polypeptides LR35PC and LR33PE (the latter in a small amount), and a unique colored polypeptide with an M(r) of 55,000, designated L55. Allophycocyanin and the core linker polypeptides are absent. The substructure of the aggregates has been studied by electron microscopy. Repetitive subcomplexes of hexameric stacks of biliproteins form extraordinary long rods associated side by side in a highly condensed arrangement. Evidence that the linker polypeptides LR35PC and LR33PE stabilize the biliprotein hexamers is presented, while the location and function of the colored linker L55 remain uncertain. The derivative strain BO 9201 contains established hemidiscoidal phycobilisomes comprising phycoerythrin, phycocyanin, and allophycocyanin as well as the corresponding linker polypeptides. The core-membrane linker protein (LCM), and two polypeptides with M(r)s of 40,000 and 45,000 which are present in small amounts, exhibit strong cross-reactivity in Western blot (immunoblot) analysis using an antibody directed against the colored LCM of a Nostoc sp. In contrast, strain BO 8402 exhibits no polypeptide with a significant immunological cross-reactivity in Western blot analysis. Physiological and genetic implications of the unusual pigment compositions of both strains are discussed. Images PMID:8300542

  14. Feasibility and effectiveness of a Chen-style Tai Chi programme for stress reduction in junior secondary school students.

    PubMed

    Lee, Linda Y K; Chong, Yeuk Lan; Li, Ngai Yin; Li, Man Chung; Lin, Lai Na; Wong, Lee Yi; Wong, Brian Kit; Yip, Wing Ping; Hon, Cho Hang; Chung, Pui Kuen; Man, Shuk Yee

    2013-04-01

    Stress is common in junior secondary school students (JSSS). This study aimed to determine the feasibility and effectiveness of a Chen-style Tai Chi programme for stress reduction in JSSS. A non-equivalent pre-test/post-test control group design was adopted, and a convenience sample of 69 JSSS was recruited. The experimental group (n = 32) joined a Chen-style Tai Chi programme, which included 10 sessions of 80-minute Tai Chi training (one session per week). The control group (n = 37) proceeded with self-study. Participants' stress levels were assessed using the Perceived Stress Scale. Feasibility was determined as the percentage of participants completing and attending the programme. Effectiveness was measured as the significant difference in changes in stress levels before and after the intervention between the two groups. Results preliminarily supported that the programme was feasible for JSSS. Completion rate was 100%, and attendance rate was 90%. However, no significant difference was noted in changes in stress levels before and after the intervention between the two groups. The potential health benefits of Tai Chi could not be detected owing to the restrictions imposed by the research setting and study limitations. The present study represents initial efforts in this direction and serves as reference for future study. PMID:22674634

  15. Quasi-spherical LuBO{sub 3} nanoparticles: Synthesis, formation, and luminescence properties

    SciTech Connect

    Gao, Yu; Yang, Feng; Han, Wenchi; Fang, Qinghong; Xu, Zhenhe

    2014-03-01

    Graphical abstract: Quasi-spherical LuBO3 nanoparticles have been prepared via a facile hydrothermal route. The possible growth mechanism and the luminescent properties of the as-prepared microcrystals have been discussed. - Highlights: • LuBO{sub 3} nanoparticles were prepared by a facile hydrothermal route. • The Eu{sup 3+} and Tb{sup 3+}-doped LuBO{sub 3} products show strong red and green emissions. • This method may be more widely applicable in the design of other rare-earth compounds. - Abstract: Quasi-spherical LuBO{sub 3} nanoparticles have been successfully synthesized by a designed hydrothermal conversion method. The Lu(OH)CO{sub 3} nanoparticles were first prepared by a simple homogeneous precipitation method. Subsequently, LuBO{sub 3} nanoparticles were synthesized at the expense of the Lu(OH)CO{sub 3} nanoparticles during a hydrothermal conversion process. The conversion process from the Lu(OH)CO{sub 3} precursor to LuBO{sub 3} nanoparticles was investigated by time-dependent experiments. Moreover, the as-obtained Eu{sup 3+} and Tb{sup 3+}-doped LuBO{sub 3} products show strong characteristic red and green emissions under ultraviolet excitation and low-voltage electron beam excitation, respectively. This work sheds some light on the knowledge of conversion of different kind of lutetium compounds, and the luminescent properties have potential applications in fluorescent lamps and field emission displays. More importantly, this simple method is expected to allow the large-scale production of other complex rare-earth compounds with controllable morphologies and sizes, and exploration of the morphology and photoluminescence properties.

  16. Thermoluminescence characteristics of Zn(BO2)2:Ce3+ under beta irradiation.

    PubMed

    Kucuk, Nil; Kucuk, Ilker; Yüksel, Mehmet; Topaksu, Mustafa

    2016-03-01

    In this study, the thermoluminescence (TL) characteristics of undoped and various Ce(3) (+)-doped Zn(BO2)2 powder samples excited by beta irradiation are reported for the first time. Zn(BO2)2:Ce(3+) powder samples were prepared by the nitric acid method (NAM) using the starting oxides [zinc oxide (ZnO), boric acid (H3BO3) and doped element oxide (CeO2)]. The formations of the obtained samples were confirmed by an X-ray diffraction study. Dose responses of Ce(3) (+)-doped Zn(BO2)2 samples were investigated after the beta irradiation in the dose range from 143 mGy to 60 Gy. All TL measurements were made on using an automated Risø TL/OSL DA-20 reader. TL emission was detected through a filter pack (Schott BG-39 and Corning 7-59) transmitting between 330 and 480 nm. TL glow curves were obtained using a constant heating rate of 5°C s(-1) from room temperature (RT) to 450°C in an N2 atmosphere. The dose response and minimum detectable dose (MDD) values of the samples were determined. The dose responses of all the samples tested exhibited a superlinear behaviour. MDD value of 4 % Ce(3) (+)-doped Zn(BO2)2 sample, which shows a high temperature peak at about 230°C, was determined as 96 mGy. MDD values for 1, 2, 3, 5 and 10 % Ce(3) (+)-doped Zn(BO2)2 samples were also determined as 682, 501, 635, 320 and 824 mGy, respectively. The trap parameters of undoped and 4 % Ce(3) (+)-doped Zn(BO2)2 samples were estimated by the computerised glow curve deconvolution method. PMID:26142459

  17. Comparison of the ligand-binding properties of native and copper-less cytochromes bo from Escherichia coli.

    PubMed Central

    Moody, A J; Mitchell, R; Jeal, A E; Rich, P R

    1997-01-01

    The binding of four anionic ligands, cyanide, fluoride, azide and formate, to cytochrome bo purified from Escherichia coli cells grown with a copper supplement (+Cu cyt.bo) is described. Membrane-bound cytochrome bo that lacks the copper component, CuB, of its active site can be prepared from cells grown under conditions where the availability of copper is limited by the presence of a CuI chelator, 2,2'-bicinchinonic acid. The ligand-binding properties of this copper-less enzyme (-Cu cyt.bo) are compared with those of +Cu cyt. bo. As judged from near-UV/visible spectroscopic changes, cyanide forms a low-spin complex with +Cu cyt.bo, whereas azide, fluoride and formate form high-spin complexes. The pH-dependences of binding suggest that for all four of these anionic ligands, both the rates of binding and the binding affinities are primarily dependent on the concentration of their protonated forms. -Cu cyt.bo, which shows less than 15% of the duroquinol oxidase activity of +Cu cyt.bo, binds cyanide, azide and fluoride, but with greatly decreased affinity (<1/30, 1/2000 and 1/2500 respectively at pH5.5 compared with +Cu cyt.bo). The complex of azide with -Cu cyt.bo still seems to be high-spin and azide binding to -Cu cyt.bo is still pH-dependent, although less so than azide binding to +Cu cyt.bo. PMID:9210397

  18. Monte Carlo and Molecular Dynamics in the Multicanonical Ensemble: Connections between Wang-Landau Sampling and Metadynamics

    NASA Astrophysics Data System (ADS)

    Vogel, Thomas; Perez, Danny; Junghans, Christoph

    2014-03-01

    We show direct formal relationships between the Wang-Landau iteration [PRL 86, 2050 (2001)], metadynamics [PNAS 99, 12562 (2002)] and statistical temperature molecular dynamics [PRL 97, 050601 (2006)], the major Monte Carlo and molecular dynamics work horses for sampling from a generalized, multicanonical ensemble. We aim at helping to consolidate the developments in the different areas by indicating how methodological advancements can be transferred in a straightforward way, avoiding the parallel, largely independent, developments tracks observed in the past.

  19. Photoluminescence Properties of CaAlBO4:M (M: Pb2+, Dy3+, and Sm3+)

    NASA Astrophysics Data System (ADS)

    Erdoğmuş, E.; Pekgözlü, İ.

    2014-07-01

    Pb2+, Dy3+, and Sm3+ doped CaAlBO4 materials were synthesized by the conventional solid state reaction. The synthesized phosphors were characterized by X-Ray powder diffraction. The emission and excitation spectra of these phosphors were measured at room temperature. The emission band of CaAlBO4:Pb2+ appeared as a broad band at 339 nm upon excitation with 272 nm. The second phosphor, CaAlBO4: Dy3+, emits at 477, 570, and 670 nm upon 347 nm excitation. The third phosphor, CaAlBO4:Sm3+, emits at 563, 594, 643, and 705 nm upon 236 nm excitation.

  20. PHOTOMETRIC PROPERTIES OF THE INTERACTING BINARY BO MONOCEROTIS: EVIDENCE FOR MAGNETIC ACTIVITY

    SciTech Connect

    Reed, Phillip A.; Yuhas, Bernard J. E-mail: byuha055@live.kutztown.edu

    2013-05-15

    BO Monocerotis (BO Mon) is a severely neglected short-period (2.23 days) Algol-type eclipsing binary star system undergoing angular momentum variations that are likely due to the evolved secondary star experiencing cycles of magnetic activity. We present the first CCD light curves of BO Mon, which were observed at the Kutztown University Observatory (Kutztown, PA) in 2012 using B, V, and I filters. The analysis presented here is the first of its kind for BO Mon and provides the first physical model of the system's parameters. We also incorporate over 40 yr of published times of minimum light to provide a new ephemeris curve and perform a period study that greatly improves, while differing significantly from, an earlier ephemeris analysis that was done more than 13 yr ago. The observed variations in BO Mon's orbital period supply evidence for mass transfer and magnetic activity and our photometric model affords the basic properties of the system for use in future photometric and spectroscopic studies.

  1. Synthesis and thermoluminescence properties of rare earth-doped NaMgBO3 phosphor.

    PubMed

    Khan, Z S; Ingale, N B; Omanwar, S K

    2016-05-01

    Rare earth (Dy(3+) and Sm(3+))-doped sodium magnesium borate (NaMgBO3) is synthesized by solution combustion synthesis method keeping their thermoluminescence properties in mind. The reaction produced very stable crystalline NaMgBO3:RE (RE = Dy(3+), Sm(3+)) phosphors. The phosphors are exposed to (60)Co gamma-ray radiations dose of varying rate from 5 to 25 Gy, and their TL characteristics with kinetic parameters are studied. NaMgBO3:Dy(3+) phosphor shows two peaks for lower doping concentration of Dy(3+) while it reduced to single peak for the higher concentrations of activator Dy(3+). NaMgBO3:Dy(3+) shows the major glow peak around 200 °C while NaMgBO3:Sm(3+) phosphors show two well-separated glow peaks at 200 and 332 °C respectively. The thermoluminescence intensity of these phosphors was compare with the commercially available TLD-100 (Harshaw) phosphor. The TL responses for gamma-ray radiations dose were found to be linear from 5 to 25 Gy for both phosphors while the fading in each case is calculated for the tenure of 45 days. PMID:26178829

  2. Superhalogens beget superhalogens: a case study of (BO2)n oligomers.

    PubMed

    Kandalam, Anil K; Kiran, Boggavarapu; Jena, P; Pietsch, S; Ganteför, G

    2015-10-28

    Superhalogens belong to a class of molecules that not only mimic the chemistry of halogen atoms but also possess electron affinities that are much larger than that of chlorine, the element with the highest electron affinity in the periodic table. Using BO2 as an example and the synergy between density functional theory-based calculations and photoelectron spectroscopy experiments we demonstrate another unusual property of superhalogens. Unlike halogens, whose ability to accept an electron falls upon dimerization, B2O4, the dimer of BO2, has an electron affinity larger than that of the BO2 building block. This ability of (BO2)2 and subsequent, higher oligomers (BO2)n (n = 3 and 4), to retain their superhalogen characteristics can be traced to the enhanced bonding interactions between oxygen and boron atoms and due to the delocalization of the charge of the extra-electron over the terminal oxygen atoms. These results open the door to the design and synthesis of a new class of metal-free highly negative ions with potential for novel applications. PMID:26394536

  3. Spectral characteristics of different structural modifications of Lu1 - x Eu x BO3

    NASA Astrophysics Data System (ADS)

    Shmurak, S. Z.; Kedrov, V. V.; Kiselev, A. P.; Smyt'ko, I. M.

    2015-01-01

    The spectral and structural characteristics of polycrystals of Eu3+-doped lutetium borates Lu1 - x Eu x BO3) annealed at different temperatures have been investigated over a wide range of europium concentrations. The conditions for the preparation of Lu1 - x Eu x BO3 in the calcite and vaterite phases have been determined. It has been found that there is a radical difference between the excitation spectra of the main emission bands of the calcite and vaterite phases of the Lu1 - x Eu x BO3 borates. The influence of the europium concentration on the structure of Lu1 - x Eu x BO3 has been analyzed. It has been established that, at europium concentrations of higher than 15 at %, only the vaterite structure is formed independently of the annealing temperature. Thus, by varying the Eu3+ concentration and the annealing temperature of Lu1 - x Eu x BO3, it is possible to directionally synthesize a specific structural modification and, consequently, to control the spectral characteristics of this compound.

  4. Signature of the Superatom to Superhalogen Behavior of Aun(BO2)m clusters

    NASA Astrophysics Data System (ADS)

    Kandalam, Anil; Gotz, Matthias; Willis, Mary; Gantefor, Gerd; Jena, Puru

    2010-03-01

    We report the discovery of a new class of clusters consisting of Aun(BO2)m which formed during the oxygenation of gold clusters when boron nitride was used as insulation in the pulsed arc cluster ion source (PACIS). Using DFT based calculations, we trace the origin of these species to be due to the unusual stability of the BO2 moiety as well as shed light on their formation process. PES measurements and the corresponding DFT calculations further reveal some rather remarkable properties of Aun(BO2)m clusters such as large HOMO-LUMO gaps in the range of 3.00 eV -- 3.95 eV and electron affinities substantially larger than that of F, the most electronegative element in the periodic table. In addition, some of the most predominant features of the electronic structure of the bare Au clusters, namely odd-even alternation in the electron affinity, are preserved in the Aun(BO2) species. The synergy between theory and experiment illustrates that Aun(BO2)m clusters, behave as superatoms and superhalogens, opening the door for the synthesis of a new class of cluster-assembled materials.

  5. Probing BoNT/A protease exosites: implications for inhibitor design and light chain longevity.

    PubMed

    Xue, Song; Javor, Sacha; Hixon, Mark S; Janda, Kim D

    2014-11-01

    Botulinum neurotoxin serotype A (BoNT/A) is one of the most lethal toxins known. Its extreme toxicity is due to its light chain (LC), a zinc protease that cleaves SNAP-25, a synaptosome-associated protein, leading to the inhibition of neuronal activity. Studies on BoNT/A LC have revealed that two regions, termed exosites, can play an important role in BoNT catalytic activity. A clear understanding of how these exosites influence neurotoxin catalytic activity would provide a critical framework for deciphering the mechanism of SNAP-25 cleavage and the design of inhibitors. Herein, based on the crystallographic structure of BoNT/A LC complexed with its substrate, we designed an α-exosite binding probe. Experiments with this unique probe demonstrated that α-exosite binding enhanced both catalytic activity and stability of the LC. These data help delineate why α-exosite binding is needed for SNAP-25 cleavage and also provide new insights into the extended lifetime observed for BoNT/A LC in vivo. PMID:25295706

  6. Toxicity of Alangium salvifolium Wang chemical constituents against the tobacco cutworm Spodoptera litura Fab.

    PubMed

    Selin-Rani, Selvaraj; Senthil-Nathan, Sengottayan; Revathi, Kannan; Chandrasekaran, Rajamanickam; Thanigaivel, Annamalai; Vasantha-Srinivasan, Prabhakaran; Ponsankar, Athirstam; Edwin, Edward Sam; Pradeepa, Venkatraman

    2016-01-01

    Widespread use of synthetic pesticides has resulted in the development of insecticide-resistant populations of pests and harmful effects on human health and the environment. There is a need to identify alternative pest management strategies to reduce our reliance on conventional chemical pesticides. In recent years the use of botanical pesticides for protecting crops from insect pests has assumed greater importance. Methanol extract of Alangium salvifolium (L.f.) Wang has potential insecticidal activity against Spodoptera litura Fab. The active fractions were identified through chromatographic techniques as F-IV (Rf value=0.45) and F-VI (Rf value=0.63) and were subjected to GC-MS (GCMATE II). Fifty, 100 and 200ppm of active fractions were applied to fourth instar larvae and the mortality increased with higher concentrations. Relative consumption rate, relative growth rate, efficiency of conversion of ingested food and efficiency of conversion of digested food values all decreased in treated larvae, but approximate digestibility rate increased after treatment. The hydrolytic enzymes, such as acid phosphatase, alkaline phosphatase and the glycolytic enzyme lactate dehydrogenase were inhibited in treated larvae compared with controls. The histopathology study revealed that the epithelial columnar cells were enlarged, completely atrophied; intercellular spaces were swollen, and also noted a cytoplasmic ooze of cell material that mixed with food column. The present study clearly showed the active fractions from A. salvifolium as potential botanicals to control the larvae of S. litura. This is the first report for nutritional indices, enzymatic activities and histological effects of A. salvifolium chemical constituents against S. litura. Thus probably, this will be used as an alternative for synthetic pesticides against the polyphagous pest like S. litura. PMID:26778440

  7. Ferromagnetism and strong magnetic anisotropy of the PbMnBO4 orthoborate single crystals

    NASA Astrophysics Data System (ADS)

    Pankrats, A.; Sablina, K.; Eremin, M.; Balaev, A.; Kolkov, M.; Tugarinov, V.; Bovina, A.

    2016-09-01

    The PbMnBO4 orthoborate single crystals were first grown and their magnetic properties and ferromagnetic resonance were studied. It was found that the ferromagnetic state below the Curie temperature TC=31 K is characterized by the strong magnetic anisotropy. The significant effective anisotropy fields of PbMnBO4 determine the energy gap in the FMR spectrum, which is extraordinary large for ferromagnets (112 GHz at T=4.2 K). It was shown that the static Jahn-Teller effect characteristic of the Mn3+ ion leads to both the ferromagnetic ordering and the strong magnetic anisotropy in the crystal. In the strong external magnetic field the induced ferromagnetic ordering is retained in the crystal above the Curie temperature up to the temperatures multiply higher than TC. A weak anomaly of the dielectric permittivity was observed in PbMnBO4 at the Curie temperature at which the long-range ferromagnetic order is established.

  8. BoD services in layer 1 VPN with dynamic virtual concatenation group

    NASA Astrophysics Data System (ADS)

    Du, Shu; Peng, Yunfeng; Long, Keping

    2008-11-01

    Bandwidth-on-Demand (BoD) services are characteristic of dynamic bandwidth provisioning based on customers' resource requirement, which will be a must for future networks. BoD services become possible with the development of make-before-break, Virtual Concatenation (VCAT) and Link Capacity Adjustment Scheme (LCAS). In this paper, we introduce BoD services into L1VPN, thus the resource assigned to a L1VPN can be gracefully adjusted at various bandwidth granularities based on customers' requirement. And we propose a dynamic bandwidth adjustment scheme, which is compromise between make-before-break and VCAT&LCAS and mainly based on the latter. The scheme minimizes the number of distinct paths to support a connection between a source-destination pair, and uses make-beforebreak technology for re-optimization.

  9. A buetschliite-type rare-earth borate, KBaY(BO 3) 2

    NASA Astrophysics Data System (ADS)

    Gao, Jianhua; Song, Limei; Hu, Xiaoyun; Zhang, Dekai

    2011-01-01

    The title compound was firstly synthesized by solid state reaction and its single crystals were successfully obtained using a selected flux. It is isotypic with the mineral buetschliite, K 2Ca(CO 3) 2, and crystallizes in the trigonal space group R-3m with a = 5.4526(12) Å, c = 17.781(8) Å, Z = 3. In the structure, Ba and K atoms are disordered on a same site in the proportion of 0.492(4):0.508(4). The fundamental building units are YO 6 octahedra and BO 3 triangles. The structure consists of [YB 2O 6] ∞ double layers constructed by corner-sharing YO 6 and BO 3 groups. Ba/K atoms occupy the spaces between these two layers and play the role of bridges. In addition, the luminescence properties of Eu 3+ doped KBaY(BO 3) 2 were also studied.

  10. Scorpion toxins for the reversal of BoNT-induced paralysis.

    PubMed

    Lowery, Colin A; Adler, Michael; Borrell, Andrew; Janda, Kim D

    2013-12-15

    The botulinum neurotoxins, characterized by their neuromuscular paralytic effects, are the most toxic proteins known to man. Due to their extreme potency, ease of production, and duration of activity, the BoNT proteins have been classified by the Centers for Disease Control as high threat agents for bioterrorism. In an attempt to discover effective BoNT therapeutics, we have pursued a strategy in which we leverage the blockade of K(+) channels that ultimately results in the reversal of neuromuscular paralysis. Towards this end, we utilized peptides derived from scorpion venom that are highly potent K(+) channel blockers. Herein, we report the synthesis of charybdotoxin, a 37 amino acid peptide, and detail its activity, along with iberiotoxin and margatoxin, in a mouse phrenic nerve hemidiaphragm assay in the absence and the presence of BoNT/A. PMID:24252544

  11. Antiatherogenic effects of the antioxidant BO-653 in three different animal models

    PubMed Central

    Cynshi, Osamu; Kawabe, Yoshiki; Suzuki, Tsukasa; Takashima, Yoshiaki; Kaise, Hiroshi; Nakamura, Minako; Ohba, Yasuhiro; Kato, Yoshiaki; Tamura, Kunio; Hayasaka, Akira; Higashida, Atsuko; Sakaguchi, Hisashi; Takeya, Motohiro; Takahashi, Kiyoshi; Inoue, Kenji; Noguchi, Noriko; Niki, Etsuo; Kodama, Tatsuhiko

    1998-01-01

    Antioxidants have been proposed to have antiatherogenic potential by their inhibition of low density lipoprotein (LDL) oxidation. Here, we report an antioxidant, BO-653 (2,3-dihydro-5-hydroxy-2,2-dipentyl-4,6-di-tert-butylbenzofuran), designed to exhibit antioxidative potency comparable to that of α-tocopherol, but yet possess a high degree of lipophilicity comparable to that of probucol. BO-653 exhibits a high affinity for LDL and is well distributed in aortic vessels in vivo. In atherosclerosis models of rabbits and mice, BO-653 has been shown to be able to suppress the formation of atherosclerotic lesions without untoward side effects. Specifically, there was no reduction of high density lipoprotein levels. This antioxidant provides additional evidence in support of the oxidized-LDL hypothesis, and itself is a promising candidate antioxidant for clinical use. PMID:9707611

  12. Bag of Lines (BoL) for Improved Aerial Scene Representation

    DOE PAGESBeta

    Sridharan, Harini; Cheriyadat, Anil M.

    2014-09-22

    Feature representation is a key step in automated visual content interpretation. In this letter, we present a robust feature representation technique, referred to as bag of lines (BoL), for high-resolution aerial scenes. The proposed technique involves extracting and compactly representing low-level line primitives from the scene. The compact scene representation is generated by counting the different types of lines representing various linear structures in the scene. Through extensive experiments, we show that the proposed scene representation is invariant to scale changes and scene conditions and can discriminate urban scene categories accurately. We compare the BoL representation with the popular scalemore » invariant feature transform (SIFT) and Gabor wavelets for their classification and clustering performance on an aerial scene database consisting of images acquired by sensors with different spatial resolutions. The proposed BoL representation outperforms the SIFT- and Gabor-based representations.« less

  13. Rapid iron borate (FeBO3) powder fabrication using microwave heating

    NASA Astrophysics Data System (ADS)

    Yang, Chia-En; Cheng, Jiping; Yin, Shizhuo

    2010-08-01

    Microwave assisted synthesis of crystalline FeBO3 powder is investigated in a multimode cavity at 2.45GHz as a possible method for faster synthesis. An Alumina-SiC susceptor enclosure was placed inside the cavity to overcome poor microwave absorption of the precursor at low temperatures. Enhanced diffusion was observed with appropriate precursor viscosity at reaction temperature. Less than 8 hours was found enough to complete FeBO3 synthesis, as compared with more than 20 hours of synthesis using conventional muffle oven. Microwave enhanced diffusion was not obvious with too high viscosity and eventually leveled by thermal diffusion with too low viscosity. The microwave synthesized FeBO3 particles were found more rhombohedral and smaller than conventional furnace synthesized ones, thus are inherently more suitable as optical composite materials.

  14. Bag of Lines (BoL) for Improved Aerial Scene Representation

    SciTech Connect

    Sridharan, Harini; Cheriyadat, Anil M.

    2014-09-22

    Feature representation is a key step in automated visual content interpretation. In this letter, we present a robust feature representation technique, referred to as bag of lines (BoL), for high-resolution aerial scenes. The proposed technique involves extracting and compactly representing low-level line primitives from the scene. The compact scene representation is generated by counting the different types of lines representing various linear structures in the scene. Through extensive experiments, we show that the proposed scene representation is invariant to scale changes and scene conditions and can discriminate urban scene categories accurately. We compare the BoL representation with the popular scale invariant feature transform (SIFT) and Gabor wavelets for their classification and clustering performance on an aerial scene database consisting of images acquired by sensors with different spatial resolutions. The proposed BoL representation outperforms the SIFT- and Gabor-based representations.

  15. Three enzymatically active neurotoxins of Clostridium botulinum strain Af84: BoNT/A2, /F4, and /F5.

    PubMed

    Kalb, Suzanne R; Baudys, Jakub; Smith, Theresa J; Smith, Leonard A; Barr, John R

    2014-04-01

    Botulinum neurotoxins (BoNTs) are produced by various species of clostridia and are potent neurotoxins which cause the disease botulism, by cleaving proteins needed for successful nerve transmission. There are currently seven confirmed serotypes of BoNTs, labeled A-G, and toxin-producing clostridia typically only produce one serotype of BoNT. There are a few strains (bivalent strains) which are known to produce more than one serotype of BoNT, producing either both BoNT/A and /B, BoNT/A and /F, or BoNT/B and /F, designated as Ab, Ba, Af, or Bf. Recently, it was reported that Clostridium botulinum strain Af84 has three neurotoxin gene clusters: bont/A2, bont/F4, and bont/F5. This was the first report of a clostridial organism containing more than two neurotoxin gene clusters. Using a mass spectrometry based proteomics approach, we report here that all three neurotoxins, BoNT/A2, /F4, and /F5, are produced by C. botulinum Af84. Label free MS(E) quantification of the three toxins indicated that toxin composition is 88% BoNT/A2, 1% BoNT/F4, and 11% BoNT/F5. The enzymatic activity of all three neurotoxins was assessed by examining the enzymatic activity of the neurotoxins upon peptide substrates, which mimic the toxins' natural targets, and monitoring cleavage of the substrates by mass spectrometry. We determined that all three neurotoxins are enzymatically active. This is the first report of three enzymatically active neurotoxins produced in a single strain of Clostridium botulinum. PMID:24605815

  16. The role of BoFLC2 in cauliflower (Brassica oleracea var. botrytis L.) reproductive development.

    PubMed

    Ridge, Stephen; Brown, Philip H; Hecht, Valérie; Driessen, Ronald G; Weller, James L

    2015-01-01

    In agricultural species that are sexually propagated or whose marketable organ is a reproductive structure, management of the flowering process is critical. Inflorescence development in cauliflower is particularly complex, presenting unique challenges for those seeking to predict and manage flowering time. In this study, an integrated physiological and molecular approach was used to clarify the environmental control of cauliflower reproductive development at the molecular level. A functional allele of BoFLC2 was identified for the first time in an annual brassica, along with an allele disrupted by a frameshift mutation (boflc2). In a segregating F₂ population derived from a cross between late-flowering (BoFLC2) and early-flowering (boflc2) lines, this gene behaved in a dosage-dependent manner and accounted for up to 65% of flowering time variation. Transcription of BoFLC genes was reduced by vernalization, with the floral integrator BoFT responding inversely. Overall expression of BoFT was significantly higher in early-flowering boflc2 lines, supporting the idea that BoFLC2 plays a key role in maintaining the vegetative state. A homologue of Arabidopsis VIN3 was isolated for the first time in a brassica crop species and was up-regulated by two days of vernalization, in contrast to findings in Arabidopsis where prolonged exposure to cold was required to elicit up-regulation. The correlations observed between gene expression and flowering time in controlled-environment experiments were validated with gene expression analyses of cauliflowers grown outdoors under 'natural' vernalizing conditions, indicating potential for transcript levels of flowering genes to form the basis of predictive assays for curd initiation and flowering time. PMID:25355864

  17. Inpatient healthcare provider bypassing by women and their children in urban Bo, Sierra Leone

    PubMed Central

    Fleming, Lila C; Ansumana, Rashid; Bockarie, Alfred; Alejandre, Joel; Bangura, Umaru; Jimmy, David Henry; Waters, Nigel; Baghi, Heibatollah; Stenger, David; Jacobsen, Kathryn H

    2016-01-01

    Introduction Bypassing refers to a person's decision to seek care at a healthcare facility that is not the nearest one of its type to the person's home. Methods This study examined inpatient care facility bypassing in urban Bo, Sierra Leone using data from 1,980 women with children 15 years of age and younger who were interviewed in 2010-2011. The locations of residential structures and hospitals were identified using a geographic information system (GIS), and the road distances from participating households to the nearest and preferred inpatient care facilities were measured. Results Nine inpatient care facilities serve Bo residents, but more than 70% of the participating women reported that the city's main public hospital (Bo Government Hospital), located in the city center, was their preferred inpatient care provider. Participants resided within a median distance of 0.9 km (Interquartile range (IQR): 0.6, 1.8) from their closest inpatient facility, but they would travel a median distance of 2.4 km (IQR: 1.0, 3.3) to reach their preferred providers. About 87% of the women would bypass their nearest inpatient care facility to access care at a preferred provider. Bypassing rates were similar for various demographic and socioeconomic groups, but higher for women living farther from the city center. Conclusion Although Bo has a diverse healthcare marketplace, access to affordable advanced care options is limited. Most women in Bo would choose to bypass facilities nearer to their homes to seek the low-cost and comprehensive care offered by Bo Government Hospital. PMID:27279971

  18. Pb2Ba3(BO3)3Cl: A Material with Large SHG Enhancement Activated by Pb-Chelated BO3 Groups.

    PubMed

    Dong, Xiaoyu; Jing, Qun; Shi, Yunjing; Yang, Zhihua; Pan, Shilie; Poeppelmeier, Kenneth R; Young, Joshua; Rondinelli, James M

    2015-07-29

    Pb(II) has long been associated with lone pair activity and is often substituted in alkali earth metal borates to create new nonlinear optical (NLO) materials with enhanced second harmonic generation (SHG) capabilities. However, large enhancement in isomorphic Pb-free analogues is rare. Here we report a new NLO material Pb2Ba3(BO3)3Cl with a phase-matching SHG response approximately 3.2× that of KDP and 6× higher than its isomorphic compound Ba5(BO3)3Cl. We show that the enhanced SHG response originates from a unique edge-sharing connection between lead-oxygen polyhedra and boron-oxygen groups, making the dielectric susceptibility more easily affected by the external electric field of an incident photon. This understanding provides a route to identify systems that would benefit from SHG-active cation substitution in isomorphic structures that exhibit weak or null SHG responses. PMID:26147880

  19. In vitro activity of a new carbapenem antibiotic, BO-2727, with potent antipseudomonal activity.

    PubMed Central

    Nakagawa, S; Hashizume, T; Matsuda, K; Sanada, M; Okamoto, O; Fukatsu, H; Tanaka, N

    1993-01-01

    BO-2727, a new 1-beta-methyl-carbapenem, was active at concentrations of 6.25 micrograms/ml or less against gram-positive and gram-negative bacteria, including some imipenem- and/or meropenem-resistant (MICs, > or = 12.5 micrograms/ml) Pseudomonas aeruginosa strains, against which it proved generally fourfold more active than imipenem and meropenem. BO-2727's antipseudomonal activity and its broad spectrum merit further investigation for clinical use by itself, since it was stable in the presence of renal dehydropeptidase I. PMID:8109950

  20. [BO-CEC National Advisory Committee Meetings and Conference: January 21, 1974; January 13, 1975; July 15, 1975:] Appendix B.

    ERIC Educational Resources Information Center

    1975

    Appendix B to the final report of the Business and Office Career Education Curriculum (BO-CEC) project contains three sections. Sections 1 and 2 briefly present the agenda, the participants, and the reports of the BO-CEC National Advisory Committee Meetings of January 1974 and January 1975. Section 3 concerns the July 1975 dissemination conference…

  1. Pb2 BO3 Cl: A Tailor-Made Polar Lead Borate Chloride with Very Strong Second Harmonic Generation.

    PubMed

    Zou, Guohong; Lin, Chensheng; Jo, Hongil; Nam, Gnu; You, Tae-Soo; Ok, Kang Min

    2016-09-19

    A meticulously designed, polar, non-centrosymmetric lead borate chloride, Pb2 BO3 Cl, was synthesized using KBe2 BO3 F2 (KBBF) as a model. Single-crystal X-ray diffraction revealed that the structure of Pb2 BO3 Cl consists of cationic [Pb2 (BO3 )](+) honeycomb layers and Cl(-) anions. Powder second harmonic generation (SHG) measurements on graded polycrystalline Pb2 BO3 Cl indicated that the title compound is phase-matchable (type I) and exhibits a remarkably strong SHG response, which is approximately nine times stronger than that of potassium dihydrogen phosphate, and the largest efficiency observed in materials with structures similar to KBBF. Further characterization suggested that the compound melts congruently at high temperature and has a wide transparency window from the near-UV to the mid-IR region. PMID:27555114

  2. In vitro evaluation of BO-3482, a novel dithiocarbamate carbapenem with activity against methicillin-resistant staphylococci.

    PubMed Central

    Adachi, Y; Nakamura, K; Kato, Y; Hazumi, N; Hashizume, T; Nakagawa, S

    1997-01-01

    BO-3482, a dithiocarbamate carbapenem, inhibited clinical isolates of methicillin-resistant staphylococci (MRS) at 6.25 microg/ml (MIC at which 90% of isolates tested are inhibited [MIC90]), while the MIC90 of imipenem was > 100 microg/ml. BO-3482 was generally less active than imipenem against methicillin-susceptible Staphylococcus aureus, streptococci, enterococci, and gram-negative bacteria, although BO-3482 showed better activity (MIC90) than imipenem against Enterococcus faecium, Haemophilus influenzae, Proteus mirabilis, and Clostridium difficile. The affinities (50% inhibitory concentrations) of BO-3482 for penicillin-binding protein (PBP) PBP 2' of MRS and PBP 5 of E. faecium (both PBPs have low affinities for ordinary beta-lactam antibiotics) were 3.8 and 20 microg/ml, respectively, reflecting the greater activity of BO-3482 against MRS than against E. faecium. PMID:9333063

  3. Characterization of the regulatory network of BoMYB2 in controlling anthocyanin biosynthesis in purple cauliflower.

    PubMed

    Chiu, Li-Wei; Li, Li

    2012-10-01

    Purple cauliflower (Brassica oleracea L. var. botrytis) Graffiti represents a unique mutant in conferring ectopic anthocyanin biosynthesis, which is caused by the tissue-specific activation of BoMYB2, an ortholog of Arabidopsis PAP2 or MYB113. To gain a better understanding of the regulatory network of anthocyanin biosynthesis, we investigated the interaction among cauliflower MYB-bHLH-WD40 network proteins and examined the interplay of BoMYB2 with various bHLH transcription factors in planta. Yeast two-hybrid studies revealed that cauliflower BoMYBs along with the other regulators formed the MYB-bHLH-WD40 complexes and BobHLH1 acted as a bridge between BoMYB and BoWD40-1 proteins. Different BoMYBs exhibited different binding activity to BobHLH1. Examination of the BoMYB2 transgenic lines in Arabidopsis bHLH mutant backgrounds demonstrated that TT8, EGL3, and GL3 were all involved in the BoMYB2-mediated anthocyanin biosynthesis. Expression of BoMYB2 in Arabidopsis caused up-regulation of AtTT8 and AtEGL3 as well as a subset of anthocyanin structural genes encoding flavonoid 3'-hydroxylase, dihydroflavonol 4-reductase, and leucoanthocyanidin dioxygenase. Taken together, our results show that MYB-bHLH-WD40 network transcription factors regulated the bHLH gene expression, which may represent a critical feature in the control of anthocyanin biosynthesis. BoMYB2 together with various BobHLHs specifically regulated the late anthocyanin biosynthetic pathway genes for anthocyanin biosynthesis. Our findings provide additional information for the complicated regulatory network of anthocyanin biosynthesis and the transcriptional regulation of transcription factors in vegetable crops. PMID:22644767

  4. Bovine herpesvirus 4 (BoHV-4) is tropic for bovine endometrial cells and modulates endocrine function

    PubMed Central

    Donofrio, Gaetano; Herath, Shan; Sartori, Chiara; Cavirani, Sandro; Flammini, Cesidio Filippo; Sheldon, Iain Martin

    2009-01-01

    Bovine postpartum uterine disease, metritis, affects about 40% of animals and is widely considered to have a bacterial aetiology. Although the gamma herpesvirus BoHV-4 has been isolated from several outbreaks of metritis or abortion, the role of viruses in endometrial pathology and the mechanisms of viral infection of uterine cells are often ignored. The objectives of the present study were to explore the interaction, tropism and outcomes of BoHV-4 challenge of endometrial stromal and epithelial cells. Endometrial stromal and epithelial cells were purified and infected with a recombinant BoHV-4 carrying an EGFP expression cassette to monitor the establishment of infection. BoHV-4 efficiently infected both stromal and epithelial cells, causing a strong non apoptotic CPE, associated with robust viral replication. The crucial step for the BoHV-4 endometriotropism appeared to be after viral entry as there was enhanced transactivation of the BoHV-4 IE2 gene promoter following transiently transfection into the endometrial cells. Infection with BoHV-4 increased COX-2 protein expression and prostaglandin E2 secretion in endometrial stromal cells, but not epithelial cells. Bovine macrophages are persistently infected with BoHV-4 and co-culture with endometrial stromal cells reactivated BoHV-4 replication in the persistently infected macrophages, suggesting a symbiotic relationship between the cells and virus. In conclusion, the present study provides evidence of cellular and molecular mechanisms supporting the concept that BoHV-4 is a pathogen associated with uterine disease. PMID:17641100

  5. A description of preimaginal stages of Pseudaspidapion botanicum Alonso-Zarazaga & Wang, 2011 (Apionidae, Curculionoidea)

    PubMed Central

    Wang, Zhiliang; Alonso-Zarazaga, M. A.; Zhou, Dakang; Zhang, Runzhi

    2013-01-01

    Abstract The preimaginal stages including egg, mature larva and pupa of Pseudaspidapion botanicum Alonso-Zarazaga & Wang, 2011 were described and figured, diagnostic characters of larva and pupa were discussed, and corresponding biological information was supplied. The nomenclature of frontal setae in the larva compared with curculionid weevils, the absence of the hypopharyngeal bracon in the larva, and the metafemoral setae in the pupa were discussed. Common and different characters among the larvae of Pseudaspidapion botanicum, Aspidapion radiolus (Marsham, 1802) and Aspidapion aeneum (Fabricius, 1775) were also provided. PMID:23653504

  6. Growth and optical properties of nonlinear LuAl3(BO3)4 crystals.

    PubMed

    Fang, Shenghao; Liu, Hua; Huang, Lingxiong; Ye, Ning

    2013-07-15

    The optical properties of pure LuAl(3)(BO(3))(4) (abbreviated as LuAB) crystals were investigated for the first time. Large UV-transparent LuAl(3)(BO(3))(4) crystals were grown by a high-temperature top-seeding method with Li(2)WO(4)O(7)-B(2)O(3) as the flux. The refractive indices of LuAl(3)(BO(3))(4) at several wavelengths covering ultraviolet-visible and near-infrared regions were measured by the auto-collimation method. The parameters of Sellmeier's dispersion equation were determined from the experimental data. The phase-matching curve of second harmonic generation was measured. The nonlinear optical coefficient d(11) of LuAB crystal was determined to be 1.10 pm/V by a phase-matching method. The UV cut-off wavelength of the LuAl(3)(BO(3))(4) crystal was shorter than 190 nm. PMID:23938492

  7. Synthesis and photoluminescence properties of Sm3+-doped YAl3(BO3)4 phosphor.

    PubMed

    Kumar, R Satheesh; Ponnusamya, V; Jose, M T

    2014-09-01

    A near ultraviolet excitable phosphor based on Sm3+-doped YAl3(BO3)4 has been synthesized by modified solid-state reaction at 1000°C. The phase purity and photoluminescence (PL) behavior of the phosphor are studied in detail using the powder X-ray diffraction technique and PL measurements. X-ray diffraction reveals that the phase purity of YAl3(BO3)4 critically depends upon the boric acid concentration. The phosphor has strong excitation at 406 nm in the near ultraviolet region (350–420 nm) and its emission peaks were monitored at 564, 599 and 643 nm. Further, detailed PL analysis demonstrates that the substitution of Sm3+ ions at sites of Y3+ and Al3+ ions enhances the PL efficiency of the phosphor appreciably. First, the PL efficiency of YAl3(BO3)4:Sm3+ was compared with commercial (Y,Gd)BO3:Eu3+ red phosphor. The Fourier transform infrared study provides essential information regarding the change in metal–oxygen bond vibrations of the phosphor. The morphology of the phosphor was investigated through scanning electron microscopy, which reveals that the phosphor possessed distorted spherical and rectangular shapes with average grain sizes in the range 0.5–1 μm. PMID:25337617

  8. 46. Quincy, MA, BO37, Launch Area, Underground Missile Storage Structure, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    46. Quincy, MA, BO-37, Launch Area, Underground Missile Storage Structure, interior view of elevator system with overhead doors in open position and hydraulic shaft in left foreground VIEW WEST - NIKE Missile Battery PR-79, Launch Area, East Windsor Road south of State Route 101, Foster, Providence County, RI

  9. Evidence that Na{sup +}-pumping occurs through the D-channel in Vitreoscilla cytochrome bo

    SciTech Connect

    Kim, Seong K.; Stark, Benjamin C.; Webster, Dale A. . E-mail: webster@iit.edu

    2005-07-01

    The operon (cyo) encoding the Na{sup +}-pumping respiratory terminal oxidase (cytochrome bo) of the bacterium Vitreoscilla was transformed into Escherichia coli GV100, a deletion mutant of cytochrome bo. This was done for the wild type operon and five mutants in three conserved Cyo subunit I amino acids known to be crucial for H{sup +} transport in the E. coli enzyme, one near the nuclear center, one in the K-channel, and one in the D-channel. CO-binding, NADH and ubiquinol oxidase, and Na{sup +}-pumping activities were all substantially inhibited by each mutation. The wild type Vitreoscilla cytochrome bo can pump Na{sup +} against a concentration gradient, resulting in a transmembrane concentration differential of 2-3 orders of magnitude. It is proposed that Vitreoscilla cytochrome bo pumps four Na{sup +} through the D-channel to the exterior and transports four H{sup +} through the K-channel for the reduction of each O{sub 2}.

  10. Cell-free synthesis of cytochrome bo(3) ubiquinol oxidase in artificial membranes.

    PubMed

    Yildiz, Ahu Arslan; Knoll, Wolfgang; Gennis, Robert B; Sinner, Eva-Kathrin

    2012-04-01

    The analysis of membrane proteins is notoriously difficult because isolation and detergent-mediated reconstitution often results in compromising the protein structure and function. We introduce a novel strategy of combining a cell-free expression method for synthesis of a protein species coping with one of the most important obstacles in membrane protein research-preserving the structural-functional integrity of a membrane protein species and providing a stable matrix for application of analytical tools to characterize the membrane protein of interest. We address integration and subsequent characterization of the cytochrome bo(3) ubiquinol oxidase (Cyt-bo(3)) from de novo synthesis without the effort of conventional cell culture, isolation, and purification procedures. The experimental output supports our idea of a suitable platform for in vitro protein synthesis and functional integration into a membrane-mimicking structure. We show the compatibility of different concepts of in vitro synthesis toward biosensor applicability by the example of Cyt-bo(3) protein expression. Our results obtained from in vitro synthesized proteins displayed similar behavior to proteins isolated from the cellular context. Overall, our approach is suitable for the in vitro expression of "complex" protein species such as Cyt-bo(3), which can be reproducible and stably synthesized and preserved in robust, synthetic planar membrane architecture. PMID:22306473

  11. High-temperature heat capacity of YFe3(BO3)4

    NASA Astrophysics Data System (ADS)

    Denisov, V. M.; Denisova, L. T.; Gudim, I. A.; Temerov, V. L.; Volkov, N. V.; Patrin, G. S.; Chumilina, L. G.

    2014-02-01

    The molar heat capacity of YFe3(BO3)4 has been measured using differential scanning calorimetry in the temperature range 339-1086 K. It has been found that the dependence C p = f( T) exhibits an extremum at a temperature of 401 K due to the structural transition.

  12. Westward view of (L to R) B&O Railroad (in West ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Westward view of (L to R) B&O Railroad (in West Virginia), Potomac River, C&O Canal (wide basin), Western Maryland Rail Trail, I-70, and US 40 (National Pike), milepost 112 vicinity. - Western Maryland Railway, Cumberland Extension, Pearre to North Branch, from WM milepost 125 to 160, Pearre, Washington County, MD

  13. Chemiluminescence of BO{sub 2} to map the creation of thermal NO in flames

    SciTech Connect

    Maligne, D. ||; Cessou, A.; Stepowski, D.

    2009-02-15

    The aim of this study is to detect and map the local conditions that generate thermal NO in flames. According to the Zeldovich mechanism, the formation of NO comes from the local conjunction of a high concentration of atomic oxygen and a temperature above a critical high level imposed by the high activation energy of the rate-limiting reaction. The green light emitted when a flame is seeded with boron salts is a chemiluminescence from the BO{sup *}{sub 2} that is chemically formed in its excited state when BO reacts with atomic oxygen. As the rate of this oxidation is also strongly increasing with temperature, the chemiluminescence of BO{sub 2} depends on the concentration of atomic oxygen and on the temperature in a way similar to the formation rate of thermal NO. This double analogy suggests the possibility of an experimental in situ simulation of the formation rate of thermal NO or at least the use of the chemiluminescence of BO{sub 2} to map the sites where thermal NO is being created. Spectroscopic experiments and comparisons with numerical simulations have been performed to test the feasibility of this technique in laminar premixed and diffusion methane/air flames. The agreement is good except in the burnt gases of fuel-rich flames. Imaging strategies with different spectral filters have been developed in the same flames to overcome the problem of interference from soot radiation in diffusion flames. (author)

  14. The Enculturation of BoMee: Looking at the World through Deaf Eyes.

    ERIC Educational Resources Information Center

    Wilcox, Sherman; Corwin, Joanne

    1990-01-01

    This paper presents a cultural model of deafness, describing the experiences of a deaf child as enculturation into a deaf world. The implications of this view on social, cognitive, and linguistic development are explored through description of BoMee, an adopted Korean deaf child being raised in a multilingual, multicultural environment.…

  15. An insertion element prevents phycobilisome synthesis in N2-fixing Synechocystis sp. strain BO 8402.

    PubMed Central

    Brass, S; Ernst, A; Böger, P

    1996-01-01

    The unicellular diazotrophic cyanobacterium Synechocystis sp. strain BO 8402, isolated from Lake Constance, contains a novel insertion sequence, IS8402, in the apcA gene encoding a pigmented protein of phycobilisomes. IS8402 comprises 1,322 bp, flanked by two inverted repeats of 15 bp. Upon insertion in the target DNA, direct duplications of 8 nucleotides were generated. One open reading frame, potentially coding for a protein of 399 amino acids, was found. The deduced amino acid sequence shows homology to putative transposases of the IS4 family. Precise excision of the insertion element resulted in a spontaneous revertant, Synechocystis sp. strain BO 9201, that had regained the ability to form hemidiscoidal phycobilisomes. Apart from the unique insertion of IS8402 into apcA in strain BO 8402 both strains contain at least 12 further homologous insertion elements at corresponding sites in the genomes. The unique insertion in strain BO 8402 prevents the expression of apcABC operon and hence abolishes the formation of intact phycobilisomes. This decreases the quantum efficiency of photosystem II and promotes anaerobic N2 fixation in a unicellular cyanobacterium with a highly oxygen-sensitive nitrogenase. PMID:8787395

  16. Educating Africans for Inferiority under British Rule: Bo School in Sierra Leone.

    ERIC Educational Resources Information Center

    Corby, Richard A.

    1990-01-01

    Sierra Leone's Bo School was established in 1906 by British colonial officials to educate chiefs' sons for subordinate positions. Nevertheless, the school contributed to creation of the postindependence ruling class. Enrollment, curriculum, student life, responsibilities of British and African teachers, and alumni networks are examined. Contains…

  17. Spectral and structural features of Lu1 - x RE x BO3 compounds

    NASA Astrophysics Data System (ADS)

    Shmurak, S. Z.; Kedrov, V. V.; Kiselev, A. P.; Fursova, T. N.; Shmyt'ko, I. M.

    2015-08-01

    The luminescence spectra, luminescence excitation spectra, IR absorption spectra, and crystal structure of orthoborates Lu1 - x RE x BO3 ( RE = Eu, Gd, Tb, Y, Dy) have been investigated. It has been found that the solid solution consisting of a LuBO3 orthoborate, which has two stable structural modifications (calcite and vaterite), and an REBO3 orthoborate, which has one structural modification (vaterite), crystallizes only in the vaterite structure when the concentration of a rare-earth ion substituting for lutetium exceeds 15-20 at %. The investigation of the photoluminescence spectra has demonstrated that, for rare-earth ions Lu3+, Eu3+, Y3+, and Gd3+ in the vaterite modification of Lu1 - x RE x BO3 orthoborates, there are at least two positions that are not equivalent in the symmetry of the local environment. It has been established that the maximum intensity of the luminescence of the vaterite modification of Lu1 - x Tb x BO3 compounds synthesized at 970°C, which is observed at a terbium concentration of 15 at %, is several times higher than the maximum intensity of the luminescence of the calcite modification.

  18. Mössbauer forward scattering on FeBO3 in the RF remagnetization regime

    NASA Astrophysics Data System (ADS)

    Sadykov, E. K.; Dzyublik, A. Ya.; Petrov, G. I.; Arinin, V. V.; Spivak, V. Yu.

    2010-10-01

    The RF Mössbauer spectra have been measured on iron borate (FeBO3) in the forward scattering scheme. A model based on the mechanism of the RF reversal of the hyperfine field reproduces all features of the observed spectra, including the appearance of satellites at the double frequency.

  19. A triple gene mutant of BoHV-1 administered intranasally in lambs replicates efficiently in the nasal epithelium and induces neutralizing antibody

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Bovine herpes virus 1 (BoHV-1) causes respiratory infections and abortions in cattle, and is an important component of Bovine respiratory disease complex (BRDC). BoHV-1 has also been isolated from sheep with respiratory disorder. Experimentally, sheep and goats are infected productively with BoHV-1...

  20. The Use of TaBoRR as a Heavy Oil Upgrader

    SciTech Connect

    Lee Brecher; Charles Mones

    2009-02-05

    Preliminary testing has shown that Western Research Institute's (WRI) Tank Bottom Recovery and Remediation (TaBoRR{reg_sign}) technology shows promise for heavy oil upgrading. Approximately 70 to 75 wt% of a Canadian Cold Lake bitumen feed was converted to a partially upgraded overhead product that could be transported directly by pipeline or blended with the parent bitumen to produce transportable crude. TaBoRR{reg_sign} was originally developed to remediate tank bottom wastes by producing a distillate product and solid waste. TaBoRR{reg_sign}'s processing steps include breaking a water-oil emulsion, recovering a light hydrocarbon fraction by distillation in a stripper unit, and pyrolyzing the residua reducing it to additional overhead and a benign coke for disposal. Cold Lake bitumen was tested in WRI's bench-scale equipment to evaluate the potential use of TaBoRR{reg_sign} technology for heavy oil upgrading to produce a stable, partially (or fully) upgraded product that will allow diluent-reduced or diluent-free transportation of bitumen or ultra-heavy crudes to market. Runs were conducted at temperatures of low, intermediate and high severity in the stripper to produce stripper overhead and bottoms. The bottoms from each of these runs were processed further in a 6-inch screw pyrolyzer to produce pyrolyzer overhead for blending with the corresponding stripper overheads. Proceeding in this fashion yielded three partially upgraded crudes. The products from TaBoRR{reg_sign} processing, the parent bitumen, and bitumen blends were subjected to stability and compatibility testing at the National Centre for Upgrading Technology (NCUT). Chemical analyses of the overhead product blends have met pipeline specifications for viscosity and density; however the bromine number does not, which might indicate the need for mild hydrotreating. Storage stability tests showed the blends to be stable. The blends were also soluble and compatible with most other Alberta crudes.

  1. Elimination of botulinum neurotoxin (BoNT) type B from drinking water by small-scale (personal-use) water purification devices and detection of BoNT in water samples.

    PubMed

    Hörman, Ari; Nevas, Mari; Lindström, Miia; Hänninen, Marja-Liisa; Korkeala, Hannu

    2005-04-01

    Seven small-scale drinking water purification devices were evaluated for their capacity to eliminate botulinum neurotoxin (BoNT) type B from drinking water. Influent water inoculated with toxic Clostridium botulinum cultures and effluent purified water samples were tested for the presence of BoNT by using a standard mouse bioassay and two commercial rapid enzyme immunoassays (EIAs). The water purification devices based on filtration through ceramic or membrane filters with a pore size of 0.2 to 0.4 microm or irradiation from a low-pressure UV-lamp (254 nm) failed to remove BoNT from raw water (reduction of < 0.1 log10 units). A single device based on reverse osmosis was capable of removing the BoNT to a level below the detection limit of the mouse bioassay (reduction of > 2.3 log10 units). The rapid EIAs intended for the detection of BoNT from various types of samples failed to detect BoNT from aqueous samples containing an estimated concentration of BoNT of 396,000 ng/liter. PMID:15812023

  2. Infrared study of lattice dynamics and spin-phonon and electron-phonon interactions in multiferroic TbF e3(BO3) 4 and GdF e3(BO3) 4

    NASA Astrophysics Data System (ADS)

    Klimin, S. A.; Kuzmenko, A. B.; Kashchenko, M. A.; Popova, M. N.

    2016-02-01

    We present a comparative far-infrared reflection spectroscopy study of phonons, phase transitions, spin-phonon, and electron-phonon interactions in isostructural multiferroic iron borates of gadolinium and terbium. The behavior of phonon modes registered in a wide temperature range is consistent with a weak first-order structural phase transition [Ts=143 for GdF e3(BO3) 4 and 200 K for TbF e3(BO3) 4 ] from a high-symmetry high-temperature R 32 structure into a low-symmetry low-temperature P 3121 one. The temperature dependences of frequencies, oscillator strengths, and damping constants of some low-frequency modes reveal an appreciable lattice anharmonicity. Peculiarities in the phonon mode behavior in both compounds at the temperature of an antiferromagnetic ordering [TN=32 K for GdF e3(BO3) 4 and 40 K for TbF e3(BO3) 4 ] evidence the spin-phonon interaction. In the energy range of phonons, GdF e3(BO3) 4 has no electronic levels, but TbF e3(BO3) 4 possesses several. We observe an onset of new bands in the excitation spectrum of TbF e3(BO3) 4 due to a resonance interaction between a lattice phonon and 4 f electronic crystal-field (CF) excitations of T b3 + . This interaction causes delocalization of the CF excitations, their Davydov splitting, and formation of coupled electron-phonon modes.

  3. Calculation of the Curie temperature of Ni using first principles based Wang-Landau Monte-Carlo

    NASA Astrophysics Data System (ADS)

    Eisenbach, Markus; Yin, Junqi; Li, Ying Wai; Nicholson, Don

    2015-03-01

    We combine constrained first principles density functional with a Wang-Landau Monte Carlo algorithm to calculate the Curie temperature of Ni. Mapping the magnetic interactions in Ni onto a Heisenberg like model to underestimates the Curie temperature. Using a model we show that the addition of the magnitude of the local magnetic moments can account for the difference in the calculated Curie temperature. For ab initio calculations, we have extended our Locally Selfconsistent Multiple Scattering (LSMS) code to constrain the magnitude of the local moments in addition to their direction and apply the Replica Exchange Wang-Landau method to sample the larger phase space efficiently to investigate Ni where the fluctuation in the magnitude of the local magnetic moments is of importance equal to their directional fluctuations. We will present our results for Ni where we compare calculations that consider only the moment directions and those including fluctuations of the magnetic moment magnitude on the Curie temperature. This research was sponsored by the Department of Energy, Offices of Basic Energy Science and Advanced Computing. We used Oak Ridge Leadership Computing Facility resources at Oak Ridge National Laboratory, supported by US DOE under contract DE-AC05-00OR22725.

  4. Boronyl chemistry: the BO group as a new ligand in gas-phase clusters and synthetic compounds.

    PubMed

    Zhai, Hua-Jin; Chen, Qiang; Bai, Hui; Li, Si-Dian; Wang, Lai-Sheng

    2014-08-19

    Boronyl (BO) is a monovalent σ radical with a robust B≡O triple bond. Although BO/BO(-) are isovalent to CN/CN(-) and CO, the chemistry of boronyl has remained relatively unknown until recently, whereas CN/CN(-) and CO are well-known inorganic ligands. Further analogy may be established for BO versus H or Au ligands, which are all monovalent σ radicals. This Account intends to provide an overview of research activities over the past few years that are relevant to the development of boronyl chemistry, in particular, in size-selected gaseous clusters containing BO. The systems covered herein include transition metal boronyl clusters, carbon boronyl clusters, boron oxide clusters and boron boronyl complexes, the boronyl boroxine, and the first synthetic Pt-BO bulk compound. In these boronyl clusters and compounds, the BO groups show remarkable structural and chemical integrity as a ligand. Among transition metal boronyls, gold monoboronyl clusters Aun(BO)(-) and Aun(BO) (n = 1-3) have been characterized, and they are shown to possess electronic and structural properties similar to the corresponding Au(n+1)(-) and Au(n+1) bare clusters, demonstrating the BO/Au analogy. The Au-B bonding in the Au-BO clusters is highly covalent. A recent advance in boronyl chemistry is the successful synthesis and isolation of the first boronyl compound, trans-[(Cy3P)2BrPt(BO)]. This unique Pt-BO compound and other potential transition metal boronyl compounds may find applications in catalysis and as chemical building blocks. Carbon boronyl clusters versus boron carbonyl clusters is a topic of interest in designing new aromatic complexes. Experimental and theoretical data obtained to date show that carbon boronyl clusters are generally far more stable than their boron carbonyl counterparts, highlighting the potency of boronyl as a ligand in aromatic compounds. Notably, in light of the BO/H analogy, the perfectly hexagonal (CBO)6 cluster is a carbon boronyl analogue of benzene. The BO

  5. Antiferromagnetically Coupled Dimeric Dodecacopper Supramolecular Architectures of Macrocyclic Ligands with a Symmetrical μ6-BO3(3-) Central Moiety.

    PubMed

    Tandon, Santokh S; Bunge, Scott D; Toth, Sara A; Sanchiz, Joaquin; Thompson, Laurence K; Shelley, Jacob T

    2015-07-20

    Reactions between 2,6-diformyl-4-alkyl(R)-phenol (R = CH3 or C(CH3)3) and 1,3-diamino-2-hydroxypropane (1,3-DAP) in the presence of copper(II) salts (Cu(BF4)2·6H2O, Cu(ClO4)2·6H2O/H3BO3/Ar) and triethylamine (TEA) in a single pot result in self-assembly of dimeric dodecacopper supramolecular architectures of 30-membered hexatopic macrocyclic ligands (H6L4 and H6L5) with unique and fascinating structures having the BO3(3-) anion as the central species bonded to all six copper centers in a symmetrical fashion (μ6-BO3(3-)). A number of closely related macrocyclic hexacopper complexes are reported: {[Cu6(L4)(μ6-BO3)(μ-H2O)(C3H7NO)2(BF4)][BF4]2·3C3H7NO}2 (1) (DMF = C3H7NO), {[Cu6(L4)(μ6-BO3)(μ-C3H7NO)3][ClO4]3·3C3H7NO}2 (2), {[Cu6(L5)(μ6-BO3)(μ-OH)(H2O)3(C3H7NO)][BF4]2·6C3H7NO·4C2H5OH·2H2O}2 (3), {[Cu6(L5)(μ6-BO3)(μ-CH3OH)(CH3OH)2][ClO4]3·10H2O}2 (4), and {[Cu6(L5)(μ6-BO3)(μ-CH3CO2)(μ-CH3O)(CH3OH)][BF4]·13CH3OH·8H2O}2 (5). A polymeric side product {[Cu2(H2L2)(CH3OH)(BF4)][BF4]}n (6), involving a 2 + 2 macrocyclic ligand, was also isolated and structurally characterized. Complex 6 involves dinuclear copper(II) units linked through BF4(-) anions to form a novel 1D single-chain polymeric coordination compound. This appears to be the first report in which a central BO3(3-) species is linked to six copper(II) ions held together by a single macrocyclic ligand through three μ1,1-O(BO3(3-)) and three μ1,3-O(BO3(3-)) bridges. In complexes 1-5 the BO3(3-) is present in the center of the macrocyclic cavity and is bonded to all six metal centers arranged in a benzene-like hexagonal array. In the hexagonal array there are alternate double (μ-alkoxide and μ1,3-O(BO3(3-))) and (μ-phenoxide and μ1,1-O(BO3(3-))) bridges between the Cu(II) centers. The symmetrical hexa-bridging nature of μ6-BO3(3-) is unprecedented in transition metal complex chemistry, and along with alkoxide and phenoxide bridges in the equatorial plane provides effective pathways for an

  6. Improved Electrochemical Performance of Carbon-Coated LiFeBO3 Nanoparticles for Lithium-Ion Batteries

    SciTech Connect

    Li, Zhaoping; Wang, Yiping; Hu, Querui; Yang, Ying; Wu, Zhuangchun; Ban, Chunmei

    2015-09-01

    Carbon-coated LiFeBO3 nanoparticles have been successfully prepared by surfactant-assisted ball milling and a size selection process based on centrifugal separation. We observed monodispersed LiFeBO3 nanoparticles with dimensions of 10–20 nm by transmission electron microscope. The introduced surfactant acts as the dispersant as well as the carbon source for LiFeBO3 nanoparticles. Greatly improved discharge capacities of 190.4 mA h g–1 at 0.1 C and 106.6 mA h g–1 at 1 C rate have been achieved in the LiFeBO3 nanoparticles when cycling the cells between 1.0 V and 4.8 V. Meanwhile, the as-prepared micro-size LiFeBO3 electrodes show lower discharge capacities of 142 mA h g–1 and 93.3 mA h g–1 at 0.1 C and 1 C rates. Moreover, the post-treated LiFeBO3 nanostructure has drastically enhanced the electrochemical performance due to the short diffusion length and ameliorated electrical contract between LiFeBO3 nano particles.

  7. Luminescence and energy transfer of white emitting phosphor YAl3(BO3)4:Ce3+, Dy3+

    NASA Astrophysics Data System (ADS)

    Zhou, Fen; Wang, Di; Cao, He-ying; Li, Jing; Song, Hui-ling; Li, Pan-lai; Wang, Zhi-jun; Zhang, Kun; Pang, Li-bin

    2015-03-01

    A white emitting phosphor of YAl3(BO3)4:Ce3+, Dy3+ is synthesized by a solid state reaction, and its luminescent properties are investigated. Its phase formation is carried out with X-ray powder diffraction analysis, and there is no crystalline phase other than YAl3(BO3)4. YAl3(BO3)4:Ce3+ can produce 422 nm blue emission under 367 nm excitation. The emission spectrum of YAl3(BO3)4:Dy3+ shows several emission peaks under 350 nm excitation, and the peaks locate at 485 nm, 575 nm and 668 nm, respectively. Emission intensities of Ce3+ and Dy3+ in YAl3(BO3)4 are influenced by their concentrations, and the concentration quenching effect is observed. Energy transfer from Ce3+ to Dy3+ in YAl3(BO3)4 is validated and proved to be a resonant type via a quadrupole-quadrupole interaction, and the emission color can be tuned from blue to white by tuning the ratio of Ce3+/Dy3+. Moreover, the critical distance ( R c) of Ce3+ to Dy3+ in YAl3(BO3)4 is calculated to be 1.904 nm.

  8. Therapeutic efficacy of BO-3482, a novel dithiocarbamate carbapenem, in mice infected with methicillin-resistant Staphylococcus aureus.

    PubMed Central

    Nagano, R; Shibata, K; Naito, T; Fuse, A; Asano, K; Hashizume, T; Nakagawa, S

    1997-01-01

    The in vivo activity of BO-3482, which has a dithiocarbamate chain at the C-2 position of 1beta-methyl-carbapenem, was compared with those of vancomycin and imipenem in murine models of septicemia and thigh infection with methicillin-resistant Staphylococcus aureus (MRSA). Because BO-3482 was more susceptible than imipenem to renal dehydropeptidase I in a kinetic study of hydrolysis by this renal enzyme, the therapeutic efficacy of BO-3482 was determined during coadministration with cilastatin. In the septicemia models, which involved two homogeneous MRSA strains and one heterogeneous MRSA strain, the 50% effective doses were, respectively, 4.80, 6.06, and 0.46 mg/kg of body weight for BO-3482; 5.56, 2.15, and 1.79 mg/kg for vancomycin; and >200, >200, and 15.9 mg/kg for imipenem. BO-3482 was also as effective as vancomycin in an MRSA septicemia model with mice with cyclophosphamide-induced immunosuppression. In the thigh infection model with a homogeneous MRSA strain, the bacterial counts in tissues treated with BO-3482-cilastatin were significantly reduced in a dose-dependent manner compared with the counts in those treated with vancomycin and imipenem-cilastatin (P < 0.001). These results indicate that BO-3482-cilastatin is as effective as vancomycin in murine systemic infections and is more bactericidal than vancomycin in local-tissue infections. The potent in vivo activity of BO-3482-cilastatin against such MRSA infections can be ascribed to the good in vitro anti-MRSA activity and improved pharmacokinetics in mice when BO-3482 is combined with cilastatin and to the bactericidal nature of the carbapenem. PMID:9333062

  9. A formulation for the characteristic lengths of fcc materials in first strain gradient elasticity via the Sutton-Chen potential

    NASA Astrophysics Data System (ADS)

    Shodja, H. M.; Tehranchi, A.

    2010-05-01

    The usual continuum theories are inadequate in predicting the mechanical behavior of solids in the presence of small defects and stress concentrators; it is well known that such continuum methods are unable to detect the change of the size of the inhomogeneities and defects. For these reasons various augmented continuum theories and strain gradient theories have been proposed in the literature. The major difficulty in implication of these theories lies in the lack of information about the additional material constants which appear in such theories. For fcc metals, for the calculation of the associated characteristic lengths which arise in first strain gradient theory, an atomistic approach based on the Sutton-Chen interatomic potential function is proposed. For the validity of the computed characteristic lengths, the phenomenon of the size effect pertinent to a nano-sized circular void within an fcc (111) plane is examined via both first strain gradient theory and lattice statics. Comparison of the results explains the physical ramifications of the characteristic lengths in improving the usual continuum results. Moreover, by reconsideration of the Kelvin problem it is shown that a commonly employed variant of the first strain gradient theory is only valid for a few fcc metals.

  10. Plasma biochemistry values in emperor geese (Chen canagica) in Alaska: comparisons among age, sex, incubation, and molt.

    USGS Publications Warehouse

    Franson, J.C.; Hoffman, D.J.; Schmutz, J.A.

    2009-01-01

    Reduced populations of emperor geese (Chen canagica), a Bering Sea endemic, provided the need to assess plasma biochemistry values as indicators of population health. A precursory step to such an investigation was to evaluate patterns of variability in plasma biochemistry values among age, sex, and reproductive period. Plasma from 63 emperor geese was collected on their breeding grounds on the Yukon-Kuskokwim Delta in western Alaska, USA. The geese sampled included 18 incubating adult females captured, in mid June, on their nests by using bow nets, and 30 adults and 15 goslings captured in corral traps in late July and early August, when the adults were molting their wing feathers and the goslings were 5-6 weeks old. Plasma was evaluated for 15 biochemical parameters, by comparing results among age, sex, and sampling period (incubation versus wing-feather molt). Ten of the 15 biochemical parameters assayed differed among adults during incubation, the adults during molt, and the goslings at molt, whereas sex differences were noted in few parameters.