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Sample records for bona-fide occupational qualification

  1. 29 CFR 1604.2 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 4 2014-07-01 2014-07-01 false Sex as a bona fide occupational qualification. 1604.2... GUIDELINES ON DISCRIMINATION BECAUSE OF SEX § 1604.2 Sex as a bona fide occupational qualification. (a) The commission believes that the bona fide occupational qualification exception as to sex should be...

  2. 29 CFR 1604.2 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 4 2011-07-01 2011-07-01 false Sex as a bona fide occupational qualification. 1604.2... GUIDELINES ON DISCRIMINATION BECAUSE OF SEX § 1604.2 Sex as a bona fide occupational qualification. (a) The commission believes that the bona fide occupational qualification exception as to sex should be...

  3. 29 CFR 1604.2 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Sex as a bona fide occupational qualification. 1604.2... GUIDELINES ON DISCRIMINATION BECAUSE OF SEX § 1604.2 Sex as a bona fide occupational qualification. (a) The commission believes that the bona fide occupational qualification exception as to sex should be...

  4. 29 CFR 1604.2 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 4 2012-07-01 2012-07-01 false Sex as a bona fide occupational qualification. 1604.2... GUIDELINES ON DISCRIMINATION BECAUSE OF SEX § 1604.2 Sex as a bona fide occupational qualification. (a) The commission believes that the bona fide occupational qualification exception as to sex should be...

  5. 29 CFR 1604.2 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 4 2013-07-01 2013-07-01 false Sex as a bona fide occupational qualification. 1604.2... GUIDELINES ON DISCRIMINATION BECAUSE OF SEX § 1604.2 Sex as a bona fide occupational qualification. (a) The commission believes that the bona fide occupational qualification exception as to sex should be...

  6. 7 CFR 15a.61 - Sex as a bona-fide occupational qualification.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 1 2014-01-01 2014-01-01 false Sex as a bona-fide occupational qualification. 15a.61... RECEIVING OR BENEFITTING FROM FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs and Activities Prohibited § 15a.61 Sex as a bona-fide...

  7. 7 CFR 15a.61 - Sex as a bona-fide occupational qualification.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Sex as a bona-fide occupational qualification. 15a.61... RECEIVING OR BENEFITTING FROM FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs and Activities Prohibited § 15a.61 Sex as a bona-fide...

  8. 7 CFR 15a.61 - Sex as a bona-fide occupational qualification.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 1 2011-01-01 2011-01-01 false Sex as a bona-fide occupational qualification. 15a.61... RECEIVING OR BENEFITTING FROM FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs and Activities Prohibited § 15a.61 Sex as a bona-fide...

  9. 7 CFR 15a.61 - Sex as a bona-fide occupational qualification.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Sex as a bona-fide occupational qualification. 15a.61... RECEIVING OR BENEFITTING FROM FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs and Activities Prohibited § 15a.61 Sex as a bona-fide...

  10. 7 CFR 15a.61 - Sex as a bona-fide occupational qualification.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 1 2012-01-01 2012-01-01 false Sex as a bona-fide occupational qualification. 15a.61... RECEIVING OR BENEFITTING FROM FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs and Activities Prohibited § 15a.61 Sex as a bona-fide...

  11. 6 CFR 17.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 6 Domestic Security 1 2011-01-01 2011-01-01 false Sex as a bona fide occupational qualification... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 17.550 Sex as...

  12. 49 CFR 25.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false Sex as a bona fide occupational qualification. 25... BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 25.550 Sex as...

  13. 29 CFR 36.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 1 2013-07-01 2013-07-01 false Sex as a bona fide occupational qualification. 36.550 Section 36.550 Labor Office of the Secretary of Labor NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex...

  14. 10 CFR 5.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Sex as a bona fide occupational qualification. 5.550 Section 5.550 Energy NUCLEAR REGULATORY COMMISSION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex...

  15. 32 CFR 196.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 2 2011-07-01 2011-07-01 false Sex as a bona fide occupational qualification... DEFENSE (CONTINUED) MISCELLANEOUS NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment...

  16. 6 CFR 17.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 6 Domestic Security 1 2013-01-01 2013-01-01 false Sex as a bona fide occupational qualification... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 17.550 Sex as...

  17. 10 CFR 5.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Sex as a bona fide occupational qualification. 5.550 Section 5.550 Energy NUCLEAR REGULATORY COMMISSION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex...

  18. 32 CFR 196.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Sex as a bona fide occupational qualification... DEFENSE (CONTINUED) MISCELLANEOUS NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment...

  19. 45 CFR 86.61 - Sex as a bona-fide occupational qualification.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Sex as a bona-fide occupational qualification. 86... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 86.61 Sex as...

  20. 29 CFR 36.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Sex as a bona fide occupational qualification. 36.550 Section 36.550 Labor Office of the Secretary of Labor NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex...

  1. 22 CFR 146.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Sex as a bona fide occupational qualification... BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 146.550 Sex as...

  2. 32 CFR 196.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Sex as a bona fide occupational qualification... DEFENSE (CONTINUED) MISCELLANEOUS NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment...

  3. 45 CFR 86.61 - Sex as a bona-fide occupational qualification.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Sex as a bona-fide occupational qualification. 86... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 86.61 Sex as...

  4. 10 CFR 1042.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Sex as a bona fide occupational qualification. 1042.550 Section 1042.550 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of...

  5. 34 CFR 106.61 - Sex as a bona-fide occupational qualification.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 1 2014-07-01 2014-07-01 false Sex as a bona-fide occupational qualification. 106.61..., DEPARTMENT OF EDUCATION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs...

  6. 6 CFR 17.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 6 Domestic Security 1 2014-01-01 2014-01-01 false Sex as a bona fide occupational qualification... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 17.550 Sex as...

  7. 34 CFR 106.61 - Sex as a bona-fide occupational qualification.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Sex as a bona-fide occupational qualification. 106.61..., DEPARTMENT OF EDUCATION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs...

  8. 22 CFR 146.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Sex as a bona fide occupational qualification... BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 146.550 Sex as...

  9. 45 CFR 618.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 3 2012-10-01 2012-10-01 false Sex as a bona fide occupational qualification. 618... FOUNDATION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or...

  10. 45 CFR 2555.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 4 2014-10-01 2014-10-01 false Sex as a bona fide occupational qualification... FOR NATIONAL AND COMMUNITY SERVICE NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment...

  11. 49 CFR 25.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false Sex as a bona fide occupational qualification. 25... BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 25.550 Sex as...

  12. 45 CFR 2555.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Sex as a bona fide occupational qualification... FOR NATIONAL AND COMMUNITY SERVICE NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment...

  13. 45 CFR 86.61 - Sex as a bona-fide occupational qualification.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Sex as a bona-fide occupational qualification. 86... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 86.61 Sex as...

  14. 10 CFR 1042.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Sex as a bona fide occupational qualification. 1042.550 Section 1042.550 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of...

  15. 32 CFR 196.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 2 2012-07-01 2012-07-01 false Sex as a bona fide occupational qualification... DEFENSE (CONTINUED) MISCELLANEOUS NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment...

  16. 34 CFR 106.61 - Sex as a bona-fide occupational qualification.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 1 2013-07-01 2013-07-01 false Sex as a bona-fide occupational qualification. 106.61..., DEPARTMENT OF EDUCATION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs...

  17. 29 CFR 36.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 1 2011-07-01 2011-07-01 false Sex as a bona fide occupational qualification. 36.550 Section 36.550 Labor Office of the Secretary of Labor NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex...

  18. 22 CFR 229.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Sex as a bona fide occupational qualification... THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 229.550 Sex...

  19. 45 CFR 618.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 3 2013-10-01 2013-10-01 false Sex as a bona fide occupational qualification. 618... FOUNDATION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or...

  20. 45 CFR 86.61 - Sex as a bona-fide occupational qualification.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Sex as a bona-fide occupational qualification. 86... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 86.61 Sex as...

  1. 49 CFR 25.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false Sex as a bona fide occupational qualification. 25... BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 25.550 Sex as...

  2. 22 CFR 229.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Sex as a bona fide occupational qualification... THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 229.550 Sex...

  3. 45 CFR 618.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 3 2014-10-01 2014-10-01 false Sex as a bona fide occupational qualification. 618... FOUNDATION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or...

  4. 49 CFR 25.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 1 2014-10-01 2014-10-01 false Sex as a bona fide occupational qualification. 25... BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 25.550 Sex as...

  5. 10 CFR 5.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Sex as a bona fide occupational qualification. 5.550 Section 5.550 Energy NUCLEAR REGULATORY COMMISSION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex...

  6. 6 CFR 17.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 6 Domestic Security 1 2012-01-01 2012-01-01 false Sex as a bona fide occupational qualification... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 17.550 Sex as...

  7. 32 CFR 196.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 2 2013-07-01 2013-07-01 false Sex as a bona fide occupational qualification... DEFENSE (CONTINUED) MISCELLANEOUS NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment...

  8. 29 CFR 36.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 1 2012-07-01 2012-07-01 false Sex as a bona fide occupational qualification. 36.550 Section 36.550 Labor Office of the Secretary of Labor NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex...

  9. 45 CFR 2555.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Sex as a bona fide occupational qualification... FOR NATIONAL AND COMMUNITY SERVICE NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment...

  10. 10 CFR 1042.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Sex as a bona fide occupational qualification. 1042.550 Section 1042.550 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of...

  11. 45 CFR 2555.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 4 2012-10-01 2012-10-01 false Sex as a bona fide occupational qualification... FOR NATIONAL AND COMMUNITY SERVICE NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment...

  12. 10 CFR 5.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Sex as a bona fide occupational qualification. 5.550 Section 5.550 Energy NUCLEAR REGULATORY COMMISSION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex...

  13. 22 CFR 146.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Sex as a bona fide occupational qualification... BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 146.550 Sex as...

  14. 34 CFR 106.61 - Sex as a bona-fide occupational qualification.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 1 2011-07-01 2011-07-01 false Sex as a bona-fide occupational qualification. 106.61..., DEPARTMENT OF EDUCATION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs...

  15. 10 CFR 1042.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Sex as a bona fide occupational qualification. 1042.550 Section 1042.550 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of...

  16. 34 CFR 106.61 - Sex as a bona-fide occupational qualification.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 1 2012-07-01 2012-07-01 false Sex as a bona-fide occupational qualification. 106.61..., DEPARTMENT OF EDUCATION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs...

  17. 22 CFR 229.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Sex as a bona fide occupational qualification... THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 229.550 Sex...

  18. 45 CFR 2555.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 4 2013-10-01 2013-10-01 false Sex as a bona fide occupational qualification... FOR NATIONAL AND COMMUNITY SERVICE NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment...

  19. 49 CFR 25.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Sex as a bona fide occupational qualification. 25... BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 25.550 Sex as...

  20. 22 CFR 229.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Sex as a bona fide occupational qualification... THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 229.550 Sex...

  1. 10 CFR 5.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Sex as a bona fide occupational qualification. 5.550 Section 5.550 Energy NUCLEAR REGULATORY COMMISSION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex...

  2. 6 CFR 17.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Sex as a bona fide occupational qualification... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 17.550 Sex as...

  3. 45 CFR 86.61 - Sex as a bona-fide occupational qualification.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Sex as a bona-fide occupational qualification. 86... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 86.61 Sex as...

  4. 22 CFR 229.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Sex as a bona fide occupational qualification... THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 229.550 Sex...

  5. 45 CFR 618.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Sex as a bona fide occupational qualification. 618... FOUNDATION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or...

  6. 29 CFR 36.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true Sex as a bona fide occupational qualification. 36.550 Section 36.550 Labor Office of the Secretary of Labor NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex...

  7. 10 CFR 1042.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Sex as a bona fide occupational qualification. 1042.550 Section 1042.550 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of...

  8. 22 CFR 146.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Sex as a bona fide occupational qualification... BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 146.550 Sex as...

  9. 45 CFR 618.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 3 2011-10-01 2011-10-01 false Sex as a bona fide occupational qualification. 618... FOUNDATION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or...

  10. 22 CFR 146.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Sex as a bona fide occupational qualification... BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 146.550 Sex as...

  11. Age Discrimination by Local Governmental Entities--The Defense of a Bona Fide Occupational Qualification.

    ERIC Educational Resources Information Center

    Hujar, Frances B.

    1979-01-01

    The bona fide occupational qualification defense is interpreted narrowly and is most likely to be applied in job situations that involve the safety of others. Available from Baylor Law Review, B.U. Station, Box 6262, Waco, TX 76706. (Author/IRT)

  12. 40 CFR 5.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Sex as a bona fide occupational... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 5.550 Sex as...

  13. 28 CFR 54.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Sex as a bona fide occupational... ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 54.550 Sex as...

  14. 31 CFR 28.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Sex as a bona fide occupational... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 28.550 Sex as...

  15. 14 CFR 1253.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Sex as a bona fide occupational... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 1253.550 Sex...

  16. 31 CFR 28.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false Sex as a bona fide occupational... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 28.550 Sex as...

  17. 43 CFR 41.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Sex as a bona fide occupational... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 41.550 Sex as...

  18. 13 CFR 113.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Sex as a bona fide occupational... ADMINISTRATOR Nondiscrimination on the Basis of Sex in Education Programs or Activities Receiving Federal Financial Assistance Discrimination on the Basis of Sex in Employment in Education Programs Or...

  19. 28 CFR 54.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Sex as a bona fide occupational... ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 54.550 Sex as...

  20. 40 CFR 5.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Sex as a bona fide occupational... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 5.550 Sex as...

  1. 40 CFR 5.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Sex as a bona fide occupational... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 5.550 Sex as...

  2. 28 CFR 54.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Sex as a bona fide occupational... ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 54.550 Sex as...

  3. 15 CFR 8a.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Sex as a bona fide occupational... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 8a.550 Sex as...

  4. 13 CFR 113.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Sex as a bona fide occupational... ADMINISTRATOR Nondiscrimination on the Basis of Sex in Education Programs or Activities Receiving Federal Financial Assistance Discrimination on the Basis of Sex in Employment in Education Programs Or...

  5. 24 CFR 3.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Sex as a bona fide occupational... and Urban Development NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in...

  6. 28 CFR 54.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Sex as a bona fide occupational... ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 54.550 Sex as...

  7. 24 CFR 3.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Sex as a bona fide occupational... and Urban Development NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in...

  8. 31 CFR 28.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Sex as a bona fide occupational... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 28.550 Sex as...

  9. 15 CFR 8a.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Sex as a bona fide occupational... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 8a.550 Sex as...

  10. 40 CFR 5.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Sex as a bona fide occupational... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 5.550 Sex as...

  11. 31 CFR 28.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false Sex as a bona fide occupational... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 28.550 Sex as...

  12. 14 CFR 1253.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Sex as a bona fide occupational... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 1253.550 Sex...

  13. 24 CFR 3.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Sex as a bona fide occupational... and Urban Development NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in...

  14. 28 CFR 54.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Sex as a bona fide occupational... ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 54.550 Sex as...

  15. 13 CFR 113.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Sex as a bona fide occupational... ADMINISTRATOR Nondiscrimination on the Basis of Sex in Education Programs or Activities Receiving Federal Financial Assistance Discrimination on the Basis of Sex in Employment in Education Programs Or...

  16. 15 CFR 8a.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Sex as a bona fide occupational... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 8a.550 Sex as...

  17. 15 CFR 8a.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Sex as a bona fide occupational... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 8a.550 Sex as...

  18. 43 CFR 41.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Sex as a bona fide occupational... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 41.550 Sex as...

  19. 13 CFR 113.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Sex as a bona fide occupational... ADMINISTRATOR Nondiscrimination on the Basis of Sex in Education Programs or Activities Receiving Federal Financial Assistance Discrimination on the Basis of Sex in Employment in Education Programs Or...

  20. 13 CFR 113.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Sex as a bona fide occupational... ADMINISTRATOR Nondiscrimination on the Basis of Sex in Education Programs or Activities Receiving Federal Financial Assistance Discrimination on the Basis of Sex in Employment in Education Programs Or...

  1. 14 CFR § 1253.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Sex as a bona fide occupational... ADMINISTRATION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or...

  2. 24 CFR 3.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Sex as a bona fide occupational... and Urban Development NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in...

  3. 31 CFR 28.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance: Treasury 1 2012-07-01 2012-07-01 false Sex as a bona fide occupational... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 28.550 Sex as...

  4. 24 CFR 3.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Sex as a bona fide occupational... and Urban Development NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in...

  5. 14 CFR 1253.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Sex as a bona fide occupational... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 1253.550 Sex...

  6. 43 CFR 41.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Sex as a bona fide occupational... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 41.550 Sex as...

  7. 43 CFR 41.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Sex as a bona fide occupational... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 41.550 Sex as...

  8. 14 CFR 1253.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Sex as a bona fide occupational... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 1253.550 Sex...

  9. 40 CFR 5.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Sex as a bona fide occupational... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 5.550 Sex as...

  10. 43 CFR 41.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Sex as a bona fide occupational... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 41.550 Sex as...

  11. 15 CFR 8a.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Sex as a bona fide occupational... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 8a.550 Sex as...

  12. 36 CFR 1211.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Sex as a bona fide... RECORDS ADMINISTRATION GENERAL RULES NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment...

  13. 44 CFR 19.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 44 Emergency Management and Assistance 1 2014-10-01 2014-10-01 false Sex as a bona fide... MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex...

  14. 18 CFR 1317.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 2 2014-04-01 2014-04-01 false Sex as a bona fide... VALLEY AUTHORITY NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs...

  15. 41 CFR 101-4.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 41 Public Contracts and Property Management 2 2012-07-01 2012-07-01 false Sex as a bona fide... ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 101-4.550...

  16. 18 CFR 1317.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Sex as a bona fide... VALLEY AUTHORITY NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs...

  17. 38 CFR 23.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2011-07-01 2011-07-01 false Sex as a bona fide... VETERANS AFFAIRS (CONTINUED) NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in...

  18. 38 CFR 23.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2012-07-01 2012-07-01 false Sex as a bona fide... VETERANS AFFAIRS (CONTINUED) NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in...

  19. 41 CFR 101-4.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Sex as a bona fide... ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 101-4.550...

  20. 38 CFR 23.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2014-07-01 2014-07-01 false Sex as a bona fide... VETERANS AFFAIRS (CONTINUED) NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in...

  1. 36 CFR 1211.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false Sex as a bona fide... RECORDS ADMINISTRATION GENERAL RULES NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment...

  2. 44 CFR 19.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 44 Emergency Management and Assistance 1 2013-10-01 2013-10-01 false Sex as a bona fide... MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex...

  3. 36 CFR 1211.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false Sex as a bona fide... RECORDS ADMINISTRATION GENERAL RULES NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment...

  4. 38 CFR 23.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Sex as a bona fide... VETERANS AFFAIRS (CONTINUED) NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in...

  5. 18 CFR 1317.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Sex as a bona fide... VALLEY AUTHORITY NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs...

  6. 18 CFR 1317.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Sex as a bona fide... VALLEY AUTHORITY NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs...

  7. 44 CFR 19.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 44 Emergency Management and Assistance 1 2012-10-01 2011-10-01 true Sex as a bona fide... MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex...

  8. 41 CFR 101-4.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 41 Public Contracts and Property Management 2 2014-07-01 2012-07-01 true Sex as a bona fide... ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 101-4.550...

  9. 41 CFR 101-4.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 2 2013-07-01 2012-07-01 true Sex as a bona fide... ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 101-4.550...

  10. 41 CFR 101-4.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 41 Public Contracts and Property Management 2 2011-07-01 2007-07-01 true Sex as a bona fide... ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 101-4.550...

  11. 18 CFR 1317.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 2 2013-04-01 2012-04-01 true Sex as a bona fide... VALLEY AUTHORITY NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs...

  12. 36 CFR 1211.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 3 2014-07-01 2014-07-01 false Sex as a bona fide... RECORDS ADMINISTRATION GENERAL RULES NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment...

  13. 44 CFR 19.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false Sex as a bona fide... MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex...

  14. 38 CFR 23.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2013-07-01 2013-07-01 false Sex as a bona fide... VETERANS AFFAIRS (CONTINUED) NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in...

  15. 36 CFR 1211.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 3 2013-07-01 2012-07-01 true Sex as a bona fide... RECORDS ADMINISTRATION GENERAL RULES NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment...

  16. 44 CFR 19.550 - Sex as a bona fide occupational qualification.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Sex as a bona fide... MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex...

  17. Age Discrimination in Employment--The Bona Fide Occupational Qualification Defense--Balancing the Interest of the Older Worker in Acquiring and Continuing Employment against the Interest in Public Safety.

    ERIC Educational Resources Information Center

    Cooper, Janet C.; Obee, John A.

    1978-01-01

    The judicial interpretations of age as a bona fide occupational qualification (BFOQ) under the Age Discrimination in Employment Act of 1967 are examined. The applications, extension, and results of these interpretations, and alternate approaches to BFOQ analysis in age discrimination cases are discussed. (BH)

  18. Catalog of Canadian fitness screening protocols for public safety occupations that qualify as a bona fide occupational requirement.

    PubMed

    Gumieniak, Robert J; Jamnik, Veronica K; Gledhill, Norman

    2013-04-01

    The purpose of this paper was to provide succinct descriptions of prominent job-specific physical fitness protocols (JSPFPs) that were constructed to satisfy the legal obligations to qualify as a bona fide occupational requirement for physically demanding public safety occupations. The intent of a JSPFP is to determine whether an applicant or incumbent possesses the necessary physical capabilities to safely and efficiently perform the critical on-the-job tasks encountered in a physically demanding occupation. The JSPFP information summarized in this report is accessible in full detail in the public domain. Therefore, prospective JSPFP participants and fitness professionals who require the information to train participants can fully inform themselves about the specific protocol requirements and associated fitness training implications. PMID:22744418

  19. 42 CFR 433.54 - Bona fide donations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 4 2014-10-01 2014-10-01 false Bona fide donations. 433.54 Section 433.54 Public... Financial Participation § 433.54 Bona fide donations. (a) A bona fide donation means a provider-related donation, as defined in § 433.52, made to the State or unit of local government, that has no direct...

  20. 42 CFR 433.54 - Bona fide donations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 4 2011-10-01 2011-10-01 false Bona fide donations. 433.54 Section 433.54 Public... Financial Participation § 433.54 Bona fide donations. (a) A bona fide donation means a provider-related donation, as defined in § 433.52, made to the State or unit of local government, that has no direct...

  1. 42 CFR 433.54 - Bona fide donations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 4 2012-10-01 2012-10-01 false Bona fide donations. 433.54 Section 433.54 Public... Financial Participation § 433.54 Bona fide donations. (a) A bona fide donation means a provider-related donation, as defined in § 433.52, made to the State or unit of local government, that has no direct...

  2. 42 CFR 433.54 - Bona fide donations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 4 2013-10-01 2013-10-01 false Bona fide donations. 433.54 Section 433.54 Public... Financial Participation § 433.54 Bona fide donations. (a) A bona fide donation means a provider-related donation, as defined in § 433.52, made to the State or unit of local government, that has no direct...

  3. 42 CFR 433.54 - Bona fide donations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Bona fide donations. 433.54 Section 433.54 Public... Financial Participation § 433.54 Bona fide donations. (a) A bona fide donation means a provider-related donation, as defined in § 433.52, made to the State or unit of local government, that has no direct...

  4. Employment Discrimination--Age Discrimination in Employment Act of 1967--Bona Fide Occupational Qualification--Hodgson v. Greyhound Lines, Inc.

    ERIC Educational Resources Information Center

    Champion, Susan Elizabeth

    1975-01-01

    Examines the circuit court's decision in favor of Greyhound in a suit alleging that the company's refusal to accept applications for bus driver from persons under 35 violated the Age Discrimination in Employment Act (ADEA). Submits that the decision frustrates congressional intent by permitting arbitrary and unreasonable age discrimination. (JT)

  5. 7 CFR 27.93 - Bona fide spot markets.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 2 2013-01-01 2013-01-01 false Bona fide spot markets. 27.93 Section 27.93 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE COMMODITY STANDARDS AND STANDARD CONTAINER REGULATIONS COTTON CLASSIFICATION UNDER COTTON...

  6. 78 FR 25181 - Revision of Regulations Defining Bona Fide Cotton Spot Markets

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-30

    ... assure consistency with the revised Cotton Research and Promotion Act. Updated bona fide spot market... Federal Register on August 4, 1988 (53 FR 29327). For each of these bona fide spot markets, the Cotton and... Service 7 CFR Part 27 RIN 0581-AD26 Revision of Regulations Defining Bona Fide Cotton Spot Markets...

  7. 78 FR 9330 - Revision of Regulations Defining Bona Fide Cotton Spot Markets

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-08

    ... Cotton Research and Promotion Act. Updated bona fide spot market definitions will allow for published... Federal Register on August 4, 1988 (53 FR 29327). For each of these bona fide spot markets, the Cotton and... Defining Bona Fide Cotton Spot Markets AGENCY: Agricultural Marketing Service, USDA. ACTION: Proposed...

  8. 17 CFR 270.10e-1 - Death, disqualification, or bona fide resignation of directors.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... bona fide resignation of directors. 270.10e-1 Section 270.10e-1 Commodity and Securities Exchanges....10e-1 Death, disqualification, or bona fide resignation of directors. If a registered investment company, by reason of the death, disqualification, or bona fide resignation of any director, does not...

  9. 29 CFR 1625.12 - Exemption for bona fide executive or high policymaking employees.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 4 2011-07-01 2011-07-01 false Exemption for bona fide executive or high policymaking employees. 1625.12 Section 1625.12 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION AGE DISCRIMINATION IN EMPLOYMENT ACT Interpretations § 1625.12 Exemption for bona fide executive or high policymaking employees....

  10. 76 FR 72921 - Proposed CERCLA Administrative Bona Fide Prospective Purchaser Settlement; The City of Dowagiac...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Proposed CERCLA Administrative Bona Fide Prospective Purchaser Settlement; The City of Dowagiac Brownfield Redevelopment Authority AGENCY: Environmental Protection Agency. ACTION: Notice; request...

  11. 29 CFR 4.156 - Employees in bona fide executive, administrative, or professional capacity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Employees in bona fide executive, administrative, or professional capacity. 4.156 Section 4.156 Labor Office of the Secretary of Labor LABOR STANDARDS FOR FEDERAL SERVICE CONTRACTS Application of the McNamara-O'Hara Service Contract Act Employees Covered by the Act § 4.156 Employees in bona fide...

  12. Fiat or Bona Fide Boundary—A Matter of Granular Perspective

    PubMed Central

    Vogt, Lars; Grobe, Peter; Quast, Björn; Bartolomaeus, Thomas

    2012-01-01

    Background Distinguishing bona fide (i.e. natural) and fiat (i.e. artificial) physical boundaries plays a key role for distinguishing natural from artificial material entities and is thus relevant to any scientific formal foundational top-level ontology, as for instance the Basic Formal Ontology (BFO). In BFO, the distinction is essential for demarcating two foundational categories of material entity: object and fiat object part. The commonly used basis for demarcating bona fide from fiat boundary refers to two criteria: (i) intrinsic qualities of the boundary bearers (i.e. spatial/physical discontinuity, qualitative heterogeneity) and (ii) mind-independent existence of the boundary. The resulting distinction of bona fide and fiat boundaries is considered to be categorial and exhaustive. Methodology/Principal Findings By referring to various examples from biology, we demonstrate that the hitherto used distinction of boundaries is not categorial: (i) spatial/physical discontinuity is a matter of scale and the differentiation of bona fide and fiat boundaries is thus granularity-dependent, and (ii) this differentiation is not absolute, but comes in degrees. By reducing the demarcation criteria to mind-independence and by also considering dispositions and historical relations of the bearers of boundaries, instead of only considering their spatio-structural properties, we demonstrate with various examples that spatio-structurally fiat boundaries can nevertheless be mind-independent and in this sense bona fide. Conclusions/Significance We argue that the ontological status of a given boundary is perspective-dependent and that the strictly spatio-structural demarcation criteria follow a static perspective that is ignorant of causality and the dynamics of reality. Based on a distinction of several ontologically independent perspectives, we suggest different types of boundaries and corresponding material entities, including boundaries based on function (locomotion

  13. 17 CFR Appendix B to Part 151 - Examples of Bona Fide Hedging Transactions and Positions

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... of a synthetic long put.521 A synthetic long put may be a bona fide hedge for anticipated production...)(B)). The synthetic long put is a substitute for transactions that the farmer will make at a later time in the physical marketing channel after the crop is harvested. The synthetic long put reduces...

  14. 17 CFR 240.16b-5 - Bona fide gifts and inheritance.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Bona fide gifts and inheritance. 240.16b-5 Section 240.16b-5 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) GENERAL RULES AND REGULATIONS, SECURITIES EXCHANGE ACT OF 1934 Rules and Regulations Under...

  15. 17 CFR 240.16b-5 - Bona fide gifts and inheritance.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Bona fide gifts and inheritance. 240.16b-5 Section 240.16b-5 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... gifts and inheritance. Both the acquisition and the disposition of equity securities shall be...

  16. Bona Fide Seniority Systems and Relief from "Last Hired, First Fired" Layoffs Under Title VII

    ERIC Educational Resources Information Center

    Spiegelman, Paul J.

    1976-01-01

    The history of the exemption for bona fide seniority systems under Title VII is explored briefly. It is suggested that the courts can provide protection for incumbent workers potentially disadvantaged, which may mean substantial monetary liability for employers using "last hired, first fired" layoff systems. (Author/LBH)

  17. 29 CFR 1625.12 - Exemption for bona fide executive or high policymaking employees.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... and issues, to develop and recommend policy direction to the top executive officers of the corporation... 29 Labor 4 2012-07-01 2012-07-01 false Exemption for bona fide executive or high policymaking... executive or high policymaking employees. (a) Section 12(c)(1) of the Act, added by the 1978 amendments...

  18. 29 CFR 1625.12 - Exemption for bona fide executive or high policymaking employees.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... and issues, to develop and recommend policy direction to the top executive officers of the corporation... 29 Labor 4 2014-07-01 2014-07-01 false Exemption for bona fide executive or high policymaking... executive or high policymaking employees. (a) Section 12(c)(1) of the Act, added by the 1978 amendments...

  19. 29 CFR 1625.12 - Exemption for bona fide executive or high policymaking employees.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... and issues, to develop and recommend policy direction to the top executive officers of the corporation... 29 Labor 4 2010-07-01 2010-07-01 false Exemption for bona fide executive or high policymaking... executive or high policymaking employees. (a) Section 12(c)(1) of the Act, added by the 1978 amendments...

  20. 29 CFR 1625.12 - Exemption for bona fide executive or high policymaking employees.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... and issues, to develop and recommend policy direction to the top executive officers of the corporation... 29 Labor 4 2013-07-01 2013-07-01 false Exemption for bona fide executive or high policymaking... executive or high policymaking employees. (a) Section 12(c)(1) of the Act, added by the 1978 amendments...

  1. Identification of the bona fide DHDPS from a common plant pathogen.

    PubMed

    Atkinson, Sarah C; Hor, Lilian; Dogovski, Con; Dobson, Renwick C J; Perugini, Matthew A

    2014-09-01

    Agrobacterium tumefaciens is a Gram-negative soil-borne bacterium that causes Crown Gall disease in many economically important crops. The absence of a suitable chemical treatment means there is a need to discover new anti-Crown Gall agents and also characterize bona fide drug targets. One such target is dihydrodipicolinate synthase (DHDPS), a homo-tetrameric enzyme that catalyzes the committed step in the metabolic pathway yielding meso-diaminopimelate and lysine. Interestingly, there are 10 putative DHDPS genes annotated in the A. tumefaciens genome, including three whose structures have recently been determined (PDB IDs: 3B4U, 2HMC, and 2R8W). However, we show using quantitative enzyme kinetic assays that nine of the 10 dapA gene products, including 3B4U, 2HMC, and 2R8W, lack DHDPS function in vitro. A sequence alignment showed that the product of the dapA7 gene contains all of the conserved residues known to be important for DHDPS catalysis and allostery. This gene was cloned and the recombinant product expressed and purified. Our studies show that the purified enzyme (i) possesses DHDPS enzyme activity, (ii) is allosterically inhibited by lysine, and (iii) adopts the canonical homo-tetrameric structure in both solution and the crystal state. This study describes for the first time the structure, function and allostery of the bona fide DHDPS from A. tumefaciens, which offers insight into the rational design of pesticide agents for combating Crown Gall disease. PMID:24677246

  2. An Evaluation of the Effects of "Bona Fide" Homogeneous Grouping on the Achievement of Elementary School Students.

    ERIC Educational Resources Information Center

    Tesh, Anita S.; Jaeger, Richard M.

    The effects of "bona fide" homogeneous grouping of students in grades 4 through 8 in a southeastern school system on the students' subsequent academic achievement were studied. These effects were studied for black students as well as for all students regardless of race, across 2 years. The student population was composed of over 4,800 fourth-…

  3. Cep295 is a conserved scaffold protein required for generation of a bona fide mother centriole

    PubMed Central

    Tsuchiya, Yuki; Yoshiba, Satoko; Gupta, Akshari; Watanabe, Koki; Kitagawa, Daiju

    2016-01-01

    Centrioles surrounded by pericentriolar material (PCM) serve as the core structure of the centrosome. A newly formed daughter centriole grows into a functional mother centriole. However, the underlying mechanisms remain poorly understood. Here we show that Cep295, an evolutionarily conserved protein, is required for generation of a bona fide mother centriole organizing a functional centrosome. We find that Cep295 is recruited to the proximal centriole wall in the early stages of procentriole assembly. Cep295 then acts as a scaffold for the proper assembly of the daughter centriole. We also find that Cep295 binds directly to and recruits Cep192 onto the daughter centriole wall, which presumably endows the function of the new mother centriole for PCM assembly, microtubule-organizing centre activity and the ability for centriole formation. These findings led us to propose that Cep295 acts upstream of the conserved pathway for centriole formation and promotes the daughter-to-mother centriole conversion. PMID:27562453

  4. Pithovirus sibericum, a new bona fide member of the “Fourth TRUC” club

    PubMed Central

    Sharma, Vikas; Colson, Philippe; Chabrol, Olivier; Pontarotti, Pierre; Raoult, Didier

    2015-01-01

    Nucleocytoplasmic large DNA viruses, or representatives of the proposed order Megavirales, include giant viruses of Acanthamoeba that were discovered over the last 12 years and are bona fide microbes. Phylogenies based on a few genes conserved amongst these megaviruses and shared by microbes classified as Eukarya, Bacteria, and Archaea, allowed for delineation of a fourth monophylogenetic group or “TRUC” (Things Resisting Uncompleted Classification) composed of the Megavirales representatives. A new Megavirales member named Pithovirus sibericum was isolated from a >30,000-year-old dated Siberian permafrost sample. This virion is as large as recently described pandoraviruses but has a genome that is approximately three to four times shorter. Our objective was to update the classification of P. sibericum as a new member of the “Fourth TRUC” club. Phylogenetic trees were constructed based on four conserved ancient genes and a phyletic analysis was concurrently conducted based on the presence/absence patterns of a set of informational genes from members of Megavirales, Bacteria, Archaea, and Eukarya. Phylogenetic analyses based on the four conserved genes revealed that P. sibericum is part of the fourth TRUC composed of Megavirales members, and is closely related to the families Marseilleviridae and Ascoviridae/Iridoviridae. Additionally, hierarchical clustering delineated four branches, and showed that P. sibericum is part of this fourth TRUC. Overall, phylogenetic and phyletic analyses using informational genes clearly indicate that P. sibericum is a new bona fide member of the “Fourth TRUC” club composed of representatives of Megavirales, alongside Bacteria, Archaea, and Eukarya. PMID:26300849

  5. Age Discrimination in Employment--The Bona Fide Occupational Qualification Defense--Balancing the Interest of the Older Worker in Acquiring and Continuing Employment against the Interest in Public Safety.

    ERIC Educational Resources Information Center

    Obee, John A.; Cooper, Janet C.

    1978-01-01

    Because further litigation probably will perpetuate the battle of the experts in age projections, the problem of determining medically the functional age of individuals should be addressed administratively by the agencies concerned with public safety and with the problems of the older worker. Available from Wayne State University Law School, 468…

  6. Bona fide interaction-driven topological phase transition in correlated SPT states

    NASA Astrophysics Data System (ADS)

    Meng, Zi Yang; He, Yuan-Yao; Wu, Han-Qing; You, Yi-Zhuang; Xu, Cenke; Lu, Zhong-Yi

    It is expected the interplay between non-trivial band topology and strong electron correlation will lead to very rich physics. Thus a controlled study of the competition between topology and correlation is of great interest. Here, employing large-scale quantum Monte Carlo simulations, we provide a concrete example of the Kane-Mele-Hubbard model on an AA stacking bilayer honeycomb lattice with inter-layer antiferromagnetic interaction. Our simulation identified several different phases: a quantum spin-Hall insulator (QSH), a xy-plane antiferromagnetic Mott insulator (xy-AFM) and an inter-layer dimer-singlet insulator (dimer-singlet). Most importantly, a bona fide topological phase transition between the QSH and the dimer-singlet insulators, purely driven by the inter-layer antiferromagnetic interaction is found. At the transition, the spin and charge gap of the system close while the single-particle excitations remain gapped, which means that this transition has no mean field analogue and it can be viewed as a transition between bosonic SPT states. At one special point, this transition is described by a (2+1)d O(4) nonlinear sigma model with exact SO(4) symmetry, and a topological term at theta=p. Relevance of this work towards more general interacting SPT states is discussed.

  7. Squalene epoxidase is a bona fide oncogene by amplification with clinical relevance in breast cancer

    PubMed Central

    Brown, David N.; Caffa, Irene; Cirmena, Gabriella; Piras, Daniela; Garuti, Anna; Gallo, Maurizio; Alberti, Saverio; Nencioni, Alessio; Ballestrero, Alberto; Zoppoli, Gabriele

    2016-01-01

    SQLE encodes squalene epoxidase, a key enzyme in cholesterol synthesis. SQLE has sporadically been reported among copy-number driven transcripts in multi-omics cancer projects. Yet, its functional relevance has never been subjected to systematic analyses. Here, we assessed the correlation of SQLE copy number (CN) and gene expression (GE) across multiple cancer types, focusing on the clinico-pathological associations in breast cancer (BC). We then investigated whether any biological effect of SQLE inhibition could be observed in BC cell line models. Breast, ovarian, and colorectal cancers showed the highest CN driven GE among 8,783 cases from 22 cancer types, with BC presenting the strongest one. SQLE overexpression was more prevalent in aggressive BC, and was an independent prognostic factor of unfavorable outcome. Through SQLE pharmacological inhibition and silencing in a panel of BC cell lines portraying the diversity of SQLE CN and GE, we demonstrated that SQLE inhibition resulted in a copy-dosage correlated decrease in cell viability, and in a noticeable increase in replication time, only in lines with detectable SQLE transcript. Altogether, our results pinpoint SQLE as a bona fide metabolic oncogene by amplification, and as a therapeutic target in BC. These findings could have implications in other cancer types. PMID:26777065

  8. MN48: a new Galactic bona fide luminous blue variable revealed by Spitzer and SALT

    NASA Astrophysics Data System (ADS)

    Kniazev, A. Y.; Gvaramadze, V. V.; Berdnikov, L. N.

    2016-07-01

    In this paper, we report the results of spectroscopic and photometric observations of the candidate evolved massive star MN48 disclosed via detection of a mid-infrared circular shell around it with the Spitzer Space Telescope. Follow-up optical spectroscopy of MN48 with the Southern African Large Telescope (SALT) carried out in 2011-2015 revealed significant changes in the spectrum of this star, which are typical of luminous blue variables (LBVs). The LBV status of MN48 was further supported by photometric monitoring which shows that in 2009-2011 this star has brightened by ≈0.9 and 1 mag in the V and Ic bands, respectively, then faded by ≈1.1 and 1.6 mag during the next four years, and apparently started to brighten again recently. The detected changes in the spectrum and brightness of MN48 make this star the 18th known Galactic bona fide LBV and increase the percentage of LBVs associated with circumstellar nebulae to more than 70 per cent. We discuss the possible birth place of MN48 and suggest that this star might have been ejected either from a putative star cluster embedded in the H II region IRAS 16455-4531 or the young massive star cluster Westerlund 1.

  9. Direct Reading of Bona Fide Barcode Assays for Diagnostics with Smartphone Apps.

    PubMed

    Wong, Jessica X H; Li, Xiaochun; Liu, Frank S F; Yu, Hua-Zhong

    2015-01-01

    The desire to develop new point-of-care (POC) diagnostic tools has led to the adaptation of smartphones to tackle limitations in state-of-the-art instrumentation and centralized laboratory facilities. Today's smartphones possess the computer-like ability to image and process data using mobile apps; barcode scanners are one such type of apps. We demonstrate herein that a diagnostic assay can be performed by patterning immunoassay strips in a bona fide barcode format such that after target binding and signal enhancement, the linear barcode can be read directly with a standard smartphone app. Quantitative analysis can then be performed based on the grayscale intensities with a customized mobile app. This novel diagnostic concept has been validated for a real-world application, i.e., the detection of human chorionic gonadotropin, a pregnancy hormone. With the possibility of multiplex detection, the barcode assay protocol promises to boost POC diagnosis research by the direct adaptation of mobile devices and apps. PMID:26122608

  10. Direct Reading of Bona Fide Barcode Assays for Diagnostics with Smartphone Apps

    NASA Astrophysics Data System (ADS)

    Wong, Jessica X. H.; Li, Xiaochun; Liu, Frank S. F.; Yu, Hua-Zhong

    2015-06-01

    The desire to develop new point-of-care (POC) diagnostic tools has led to the adaptation of smartphones to tackle limitations in state-of-the-art instrumentation and centralized laboratory facilities. Today’s smartphones possess the computer-like ability to image and process data using mobile apps; barcode scanners are one such type of apps. We demonstrate herein that a diagnostic assay can be performed by patterning immunoassay strips in a bona fide barcode format such that after target binding and signal enhancement, the linear barcode can be read directly with a standard smartphone app. Quantitative analysis can then be performed based on the grayscale intensities with a customized mobile app. This novel diagnostic concept has been validated for a real-world application, i.e., the detection of human chorionic gonadotropin, a pregnancy hormone. With the possibility of multiplex detection, the barcode assay protocol promises to boost POC diagnosis research by the direct adaptation of mobile devices and apps.

  11. Bona fide interaction-driven topological phase transition in correlated symmetry-protected topological states

    NASA Astrophysics Data System (ADS)

    He, Yuan-Yao; Wu, Han-Qing; You, Yi-Zhuang; Xu, Cenke; Meng, Zi Yang; Lu, Zhong-Yi

    2016-03-01

    It is expected that the interplay between nontrivial band topology and strong electron correlation will lead to very rich physics. Thus a controlled study of the competition between topology and correlation is of great interest. Here, employing large-scale quantum Monte Carlo simulations, we provide a concrete example of the Kane-Mele-Hubbard model on an AA-stacking bilayer honeycomb lattice with interlayer antiferromagnetic interaction. Our simulation identified several different phases: a quantum spin Hall insulator (QSH), an x y -plane antiferromagnetic Mott insulator, and an interlayer dimer-singlet insulator. Most importantly, a bona fide topological phase transition between the QSH and the dimer-singlet insulators, purely driven by the interlayer antiferromagnetic interaction, is found. At the transition, the spin and charge gap of the system close while the single-particle excitations remain gapped, which means that this transition has no mean-field analog and it can be viewed as a transition between bosonic symmetry-protected topological (SPT) states. At one special point, this transition is described by a (2 +1 )d O (4 ) nonlinear sigma model with exact S O (4 ) symmetry and a topological term at exactly Θ =π . The relevance of this work towards more general interacting SPT states is discussed.

  12. Direct Reading of Bona Fide Barcode Assays for Diagnostics with Smartphone Apps

    PubMed Central

    Wong, Jessica X. H.; Li, Xiaochun; Liu, Frank S. F.; Yu, Hua-Zhong

    2015-01-01

    The desire to develop new point-of-care (POC) diagnostic tools has led to the adaptation of smartphones to tackle limitations in state-of-the-art instrumentation and centralized laboratory facilities. Today’s smartphones possess the computer-like ability to image and process data using mobile apps; barcode scanners are one such type of apps. We demonstrate herein that a diagnostic assay can be performed by patterning immunoassay strips in a bona fide barcode format such that after target binding and signal enhancement, the linear barcode can be read directly with a standard smartphone app. Quantitative analysis can then be performed based on the grayscale intensities with a customized mobile app. This novel diagnostic concept has been validated for a real-world application, i.e., the detection of human chorionic gonadotropin, a pregnancy hormone. With the possibility of multiplex detection, the barcode assay protocol promises to boost POC diagnosis research by the direct adaptation of mobile devices and apps. PMID:26122608

  13. N,N'-Diamidocarbenes: Isolable Divalent Carbons with Bona Fide Carbene Reactivity.

    PubMed

    Moerdyk, Jonathan P; Schilter, David; Bielawski, Christopher W

    2016-08-16

    Since the first reported isolation of a carbene just over a quarter century ago, the study of such compounds-including stable derivatives-has flourished. Indeed, N-heterocyclic carbenes (NHCs), of which imidazolylidenes and their derivatives are the most pervasive subclass, feature prominently in organocatalysis, as ligands for transition metal catalysts, and as stabilizers of reactive species. However, imidazolylidenes (and many other NHCs) typically lack the reactivity characteristic of electrophilic carbenes, including insertion into unactivated C-H bonds, participation in [2 + 1] cycloadditions, and reaction with carbon monoxide. This has led to debates over whether NHCs are truly carbenic in nature or perhaps better regarded as ylides. The fundamental and synthetic utility of transformations that involve electrophilic carbenes has motivated our group and others to expand the reactivity of NHCs and other stable carbenes to encompass electrophilic carbene chemistry. These efforts have led to the development of the diamidocarbenes (DACs), a stable and unique subset of the NHCs that feature carbonyl groups inserted into the N-heterocyclic scaffold. To date, crystalline five-, six-, and seven-membered DACs have been prepared and studied. Unlike imidazolylidenes, which are often designated as prototypical NHCs, the DACs exhibit a reactivity profile similar to that of bona fide carbenes, reactive species that are less "tamed" by heteroatom π conjugation. The DACs engage in [2 + 1] cycloadditions with electron-rich or -poor alkenes, aldehydes, alkynes, and nitriles, and doing so in a reversible manner in some cases. They also react with isonitriles, reversibly couple to CO, and mediate the dehydrogenation of hydrocarbons. Such rich chemistry may be rationalized in terms of their ambiphilicity: DACs are nucleophilic, as required for some of the reactions above, yet also have electrophilic character, as evidenced by their insertions into unactivated N-H and C-H bonds

  14. A Resource for the Transcriptional Signature of Bona Fide Trophoblast Stem Cells and Analysis of Their Embryonic Persistence

    PubMed Central

    Pfeifer, Dietmar; Arnold, Sebastian J.

    2015-01-01

    Trophoblast stem cells (TSCs) represent the multipotent progenitors that give rise to the different cells of the embryonic portion of the placenta. Here, we analysed the expression of key TSC transcription factors Cdx2, Eomes, and Elf5 in the early developing placenta of mouse embryos and in cultured TSCs and reveal surprising heterogeneity in protein levels. We analysed persistence of TSCs in the early placenta and find that TSCs remain in the chorionic hinge until E9.5 and are lost shortly afterwards. To define the transcriptional signature of bona fide TSCs, we used inducible gain- and loss-of-function alleles of Eomes or Cdx2, and EomesGFP, to manipulate and monitor the core maintenance factors of TSCs, followed by genome-wide expression profiling. Combinatorial analysis of resulting expression profiles allowed for defining novel TSC marker genes that might functionally contribute to the maintenance of the TSC state. Analyses by qRT-PCR and in situ hybridisation validated novel TSC- and chorion-specific marker genes, such as Bok/Mtd, Cldn26, Duox2, Duoxa2, Nr0b1, and Sox21. Thus, these expression data provide a valuable resource for the transcriptional signature of bona fide and early differentiating TSCs and may contribute to an increased understanding of the transcriptional circuitries that maintain and/or establish stemness of TSCs. PMID:26783396

  15. The vapB–vapC Operon of Acidovorax citrulli Functions as a Bona-fide Toxin–Antitoxin Module

    PubMed Central

    Shavit, Reut; Lebendiker, Mario; Pasternak, Zohar; Burdman, Saul; Helman, Yael

    2016-01-01

    Toxin–antitoxin systems are commonly found on plasmids and chromosomes of bacteria and archaea. These systems appear as biscystronic genes encoding a stable toxin and a labile antitoxin, which protects the cells from the toxin’s activity. Under specific, mostly stressful conditions, the unstable antitoxin is degraded, the toxin becomes active and growth is arrested. Using genome analysis we identified a putative toxin–antitoxin encoding system in the genome of the plant pathogen Acidovorax citrulli. The system is homologous to vapB–vapC systems from other bacterial species. PCR and phylogenetic analyses suggested that this locus is unique to group II strains of A. citrulli. Using biochemical and molecular analyses we show that A. citrulli VapBC module is a bona-fide toxin–antitoxin module in which VapC is a toxin with ribonuclease activity that can be counteracted by its cognate VapB antitoxin. We further show that transcription of the A. citrulli vapBC locus is induced by amino acid starvation, chloramphenicol and during plant infection. Due to the possible role of TA systems in both virulence and dormancy of human pathogenic bacteria, studies of these systems are gaining a lot of attention. Conversely, studies characterizing toxin–antitoxin systems in plant pathogenic bacteria are lacking. The study presented here validates the activity of VapB and VapC proteins in A. citrulli and suggests their involvement in stress response and host–pathogen interactions. PMID:26779154

  16. Nanoceria as bona fide catalytic antioxidants in medicine: what we know and what we want to know….

    PubMed

    Wong, Lily L; McGinnis, James F

    2014-01-01

    Cerium oxide (CeO2) nanoparticles, CeNPs or nanoceria are inorganic and possess catalytic antioxidant activity. They scavenge reactive oxygen species and act as an oxygen buffer. Their application in industry is well-established. However, their usage as bona fide antioxidants in biological systems has been recent and is quite revolutionary. Other reviews have documented nanoceria's protective effect in reducing oxidative stress in cell culture and in animal disease models that are associated with oxidative stress. We specifically have targeted CeNPs as ophthalmic therapeutics to slow the progression of retinal degeneration and as anti-angiogenic agents in rodent models. The radical scavenging activity of CeNPs is mainly due to the dramatic increase of surface area to volume ratio in these nanocrystalline structures. The parameters for CeNPs usage in industrial settings are decidedly not suitable for biological applications. In this short review, we report the pharmacokinetics, biodistribution, and toxicity evaluation of CeNPs when applied as ophthalmic therapeutic agents in an in vivo system. We highlight studies that examine how CeNPs behave in biological environments and how they interact with bio-macromolecules. We also discuss studies that examine the dynamic changes of the surface chemistry of CeNPs in physiological buffers. Finally, we raise a list of questions that we think ought to be answered for CeNPs to be considered the antioxidants of choice in medicine, specifically in the treatment of ocular diseases. PMID:24664776

  17. Bap1 Is a Bona Fide Tumor Suppressor: Genetic Evidence from Mouse Models Carrying Heterozygous Germline Bap1 Mutations.

    PubMed

    Kadariya, Yuwaraj; Cheung, Mitchell; Xu, Jinfei; Pei, Jianming; Sementino, Eleonora; Menges, Craig W; Cai, Kathy Q; Rauscher, Frank J; Klein-Szanto, Andres J; Testa, Joseph R

    2016-05-01

    Individuals harboring inherited heterozygous germline mutations in BAP1 are predisposed to a range of benign and malignant tumor types, including malignant mesothelioma, melanoma, and kidney carcinoma. However, evidence to support a tumor-suppressive role for BAP1 in cancer remains contradictory. To test experimentally whether BAP1 behaves as a tumor suppressor, we monitored spontaneous tumor development in three different mouse models with germline heterozygous mutations in Bap1, including two models in which the knock-in mutations are identical to those reported in human BAP1 cancer syndrome families. We observed spontaneous malignant tumors in 54 of 93 Bap1-mutant mice (58%) versus 4 of 43 (9%) wild-type littermates. All three Bap1-mutant models exhibited a high incidence and similar spectrum of neoplasms, including ovarian sex cord stromal tumors, lung and mammary carcinomas, and spindle cell tumors. Notably, we also observed malignant mesotheliomas in two Bap1-mutant mice, but not in any wild-type animals. We further confirmed that the remaining wild-type Bap1 allele was lost in both spontaneous ovarian tumors and mesotheliomas, resulting in the loss of Bap1 expression. Additional studies revealed that asbestos exposure induced a highly significant increase in the incidence of aggressive mesotheliomas in the two mouse models carrying clinically relevant Bap1 mutations compared with asbestos-exposed wild-type littermates. Collectively, these findings provide genetic evidence that Bap1 is a bona fide tumor suppressor gene and offer key insights into the contribution of carcinogen exposure to enhanced cancer susceptibility. Cancer Res; 76(9); 2836-44. ©2016 AACR. PMID:26896281

  18. Defenses under the Age Discrimination in Employment Act: Misinterpretation, Misdirection, and the 1978 Amendments.

    ERIC Educational Resources Information Center

    Player, Mack A.

    1978-01-01

    Three exceptions or defenses to the Age Discrimination in Employment Act of 1967 are analyzed--the bona fide occupational qualification, bona fide seniority system, and bona fide benefit plan. Available from Georgia Law Review, University of Georgia School of Law, Athens, Georgia 30602; sc $3.50. (IRT)

  19. Conservation of major and minor jelly-roll capsid proteins in Polinton (Maverick) transposons suggests that they are bona fide viruses

    PubMed Central

    2014-01-01

    Reviewers This article was reviewed by Lakshminarayan M. Iyer and I. King Jordan. For complete reviews, see the Reviewers’ Reports section. Polintons (also known as Mavericks) and Tlr elements of Tetrahymena thermophila represent two families of large DNA transposons widespread in eukaryotes. Here, we show that both Polintons and Tlr elements encode two key virion proteins, the major capsid protein with the double jelly-roll fold and the minor capsid protein, known as the penton, with the single jelly-roll topology. This observation along with the previously noted conservation of the genes for viral genome packaging ATPase and adenovirus-like protease strongly suggests that Polintons and Tlr elements combine features of bona fide viruses and transposons. We propose the name ‘Polintoviruses’ to denote these putative viruses that could have played a central role in the evolution of several groups of DNA viruses of eukaryotes. PMID:24773695

  20. SCF(JFK) is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer.

    PubMed

    Yan, Ruorong; He, Lin; Li, Zhongwu; Han, Xiao; Liang, Jing; Si, Wenzhe; Chen, Zhe; Li, Lei; Xie, Guojia; Li, Wanjin; Wang, Peiyan; Lei, Liandi; Zhang, Hongquan; Pei, Fei; Cao, Dengfeng; Sun, Luyang; Shang, Yongfeng

    2015-03-15

    Loss of function/dysregulation of inhibitor of growth 4 (ING4) and hyperactivation of NF-κB are frequent events in many types of human malignancies. However, the molecular mechanisms underlying these remarkable aberrations are not understood. Here, we report that ING4 is physically associated with JFK. We demonstrated that JFK targets ING4 for ubiquitination and degradation through assembly of an Skp1-Cul1-F-box (SCF) complex. We showed that JFK-mediated ING4 destabilization leads to the hyperactivation of the canonical NF-κB pathway and promotes angiogenesis and metastasis of breast cancer. Significantly, the expression of JFK is markedly up-regulated in breast cancer, and the level of JFK is negatively correlated with that of ING4 and positively correlated with an aggressive clinical behavior of breast carcinomas. Our study identified SCF(JFK) as a bona fide E3 ligase for ING4 and unraveled the JFK-ING4-NF-κB axis as an important player in the development and progression of breast cancer, supporting the pursuit of JFK as a potential target for breast cancer intervention. PMID:25792601

  1. BONA FIDE, STRONG-VARIABLE GALACTIC LUMINOUS BLUE VARIABLE STARS ARE FAST ROTATORS: DETECTION OF A HIGH ROTATIONAL VELOCITY IN HR CARINAE

    SciTech Connect

    Groh, J. H.; Damineli, A.; Moises, A. P.; Teodoro, M.; Hillier, D. J.; Barba, R.; Fernandez-Lajus, E.; Gamen, R. C.; Solivella, G.

    2009-11-01

    We report optical observations of the luminous blue variable (LBV) HR Carinae which show that the star has reached a visual minimum phase in 2009. More importantly, we detected absorptions due to Si IV lambdalambda4088-4116. To match their observed line profiles from 2009 May, a high rotational velocity of v{sub rot} approx = 150 +- 20 km s{sup -1} is needed (assuming an inclination angle of 30 deg.), implying that HR Car rotates at approx =0.88 +- 0.2 of its critical velocity for breakup (v{sub crit}). Our results suggest that fast rotation is typical in all strong-variable, bona fide galactic LBVs, which present S-Dor-type variability. Strong-variable LBVs are located in a well-defined region of the HR diagram during visual minimum (the 'LBV minimum instability strip'). We suggest this region corresponds to where v{sub crit} is reached. To the left of this strip, a forbidden zone with v{sub rot}/v{sub crit}>1 is present, explaining why no LBVs are detected in this zone. Since dormant/ex LBVs like P Cygni and HD 168625 have low v{sub rot}, we propose that LBVs can be separated into two groups: fast-rotating, strong-variable stars showing S-Dor cycles (such as AG Car and HR Car) and slow-rotating stars with much less variability (such as P Cygni and HD 168625). We speculate that supernova (SN) progenitors which had S-Dor cycles before exploding (such as in SN 2001ig, SN 2003bg, and SN 2005gj) could have been fast rotators. We suggest that the potential difficulty of fast-rotating Galactic LBVs to lose angular momentum is additional evidence that such stars could explode during the LBV phase.

  2. Bona Fide, Strong-Variable Galactic Luminous Blue Variable Stars are Fast Rotators: Detection of a High Rotational Velocity in HR Carinae

    NASA Astrophysics Data System (ADS)

    Groh, J. H.; Damineli, A.; Hillier, D. J.; Barbá, R.; Fernández-Lajús, E.; Gamen, R. C.; Moisés, A. P.; Solivella, G.; Teodoro, M.

    2009-11-01

    We report optical observations of the luminous blue variable (LBV) HR Carinae which show that the star has reached a visual minimum phase in 2009. More importantly, we detected absorptions due to Si IV λλ4088-4116. To match their observed line profiles from 2009 May, a high rotational velocity of v rot sime 150 ± 20 km s-1 is needed (assuming an inclination angle of 30°), implying that HR Car rotates at sime0.88 ± 0.2 of its critical velocity for breakup (v crit). Our results suggest that fast rotation is typical in all strong-variable, bona fide galactic LBVs, which present S-Dor-type variability. Strong-variable LBVs are located in a well-defined region of the HR diagram during visual minimum (the "LBV minimum instability strip"). We suggest this region corresponds to where v crit is reached. To the left of this strip, a forbidden zone with v rot/v crit>1 is present, explaining why no LBVs are detected in this zone. Since dormant/ex LBVs like P Cygni and HD 168625 have low v rot, we propose that LBVs can be separated into two groups: fast-rotating, strong-variable stars showing S-Dor cycles (such as AG Car and HR Car) and slow-rotating stars with much less variability (such as P Cygni and HD 168625). We speculate that supernova (SN) progenitors which had S-Dor cycles before exploding (such as in SN 2001ig, SN 2003bg, and SN 2005gj) could have been fast rotators. We suggest that the potential difficulty of fast-rotating Galactic LBVs to lose angular momentum is additional evidence that such stars could explode during the LBV phase. Based on observations made with the 1.6 m telescope at the Observatório Pico dos Dias (OPD-LNA, Brazil), with the 2.15 m telescope of the Complejo Astronomico El Leoncito (CASLEO, Argentina), and with the 2.2 m ESO telescope at La Silla (Chile) under program 083.D-0589. CASLEO is operated under agreement between CONICET, SECYT, and the National Universities of La Plata, Córdoba and San Juan, Argentina.

  3. The Role of Qualifications in Governing Occupations and Professions. Working Paper No 20

    ERIC Educational Resources Information Center

    Cedefop - European Centre for the Development of Vocational Training, 2013

    2013-01-01

    Qualifications are commonly seen as one of the core instruments for governing and regulating the labour market. Linked to access to occupations and professions, qualifications define what a person needs to know and be able to do to carry out a certain activity on the labour market. Various factors, from health and safety to consumer protection and…

  4. From School to Work. A Comparative Study of Educational Qualifications and Occupational Destinations.

    ERIC Educational Resources Information Center

    Shavit, Yossi, Ed.; Muller, Walter, Ed.

    The 15 chapters in this book deal with varying institutional characteristics of educational systems and their effects on occupational outcomes. "The Institutional Embeddedness of the Stratification Process: A Comparative Study of Qualifications and Occupations in Thirteen Countries" (Walter Mueller, Yossi Shavit) discusses results of a comparative…

  5. European Trends in the Development of Occupations and Qualifications. Volume I. CEDEFOP Reference Document.

    ERIC Educational Resources Information Center

    Sellin, Burkart

    This document is intended to provide updated information on the most important trends in the development of occupations and qualifications in Europe in the face of current demographic, social, economic, technical, environmental, and cultural challenges. It provides a general summary of the most important trends at the macro level, and makes…

  6. Trends in the Structure of Qualifications for Occupations Relating to Computer Networks.

    ERIC Educational Resources Information Center

    CEDEFOP Flash, 1994

    1994-01-01

    A 1993 study compared trends in the structure of qualifications for occupations related to the installation, management, and maintenance of computer networks in Germany, France, Italy, the Netherlands, Portugal, and the United Kingdom. Staff involved in networks required specialized new skills related to feasibility and design, installation,…

  7. Developing legally defensible physiological employment standards for prominent physically demanding public safety occupations: a Canadian perspective.

    PubMed

    Jamnik, V; Gumienak, R; Gledhill, N

    2013-10-01

    Canadian court decisions and human rights legislation impose strict legal criteria for developing applicant and incumbent physiological employment standards to qualify as a bona fide occupational requirement. These legal criteria compel researchers and employers to ensure that the standards are criterion-based and validly linked to the critical life threatening physically demanding tasks of the occupation, and this has led to the establishment of a systematic research process template to ensure this connection. Validation of job-related physiological employment standards is achieved using both construct and content procedures and reliability is established via test-retest procedures. The 1999 Supreme Court of Canada Meiorin Decision also obliges employers to demonstrate that it is impossible to accommodate an individual applicant or employee who is adversely impacted by lowering the physiological employment standards without imposing undue hardship on the employer. Recent evidence has demonstrated convincingly that familiarization opportunities, motivational feedback/coaching during test performance, and participation in a 6-week job-specific physical fitness training program can overcome the adverse impact of a physiological employment standards on a sub-group of participants, thereby providing "de facto" accommodation. In this article, the authors review the physiological employment standards for prominent Canadian physically demanding public safety occupations; police, correctional officers, nuclear emergency personnel, structural fire fighters, and wildland fire fighters, to illustrate the steps, challenges, and solutions involved in developing and implementing physiological employment standards designed to meet the requirements to qualify as a bona fide occupational requirement. PMID:23494548

  8. [Occupational medicine qualification examination and check-up].

    PubMed

    Heierli, C

    1984-01-01

    At the examination of a future apprentice his health conditions and the strain he may experience in his chosen trade are compared. The recommendation to choose an other trade shall be given in cases of important inadequacies. Examples of such cases and the outcome of these apprenticeships collected from a survey of all apprenticeships in Basle starting in 1973-77 are given. Measures preventing such inadequacies are suggested. Periodic examinations are prescribed by the Swiss workers compensation law in cases a worker runs an actual risk of noxious exposures at his place of work. The rationale is to prevent strain as mentioned above and to reveal any occupational disease or similar problem related to the daily work. PMID:6711140

  9. Anticipation of Occupation and Qualification Trends in the European Union: Innovations for Effective Anticipation of Qualification and Competence Trends and the Adaptation of VET Provision in Member States.

    ERIC Educational Resources Information Center

    Sellin, Burkart, Ed.

    The approaches being taken and innovations being adopted at the national and European levels to anticipate occupation and qualification trends in the European Union (EU) were examined in a survey of the 15 EU member states. The survey findings were presented by country and in a synthesis. In addition, the findings for Belgium were broken down by…

  10. 29 CFR 1604.3 - Separate lines of progression and seniority systems.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... GUIDELINES ON DISCRIMINATION BECAUSE OF SEX § 1604.3 Separate lines of progression and seniority systems. (a... lines of progression or separate seniority lists based on sex where this would adversely affect any employee unless sex is a bona fide occupational qualification for that job. Accordingly,...

  11. 29 CFR 1604.5 - Job opportunities advertising.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 4 2011-07-01 2011-07-01 false Job opportunities advertising. 1604.5 Section 1604.5 Labor... BECAUSE OF SEX § 1604.5 Job opportunities advertising. It is a violation of title VII for a help-wanted... a bona fide occupational qualification for the particular job involved. The placement of...

  12. 29 CFR 1604.5 - Job opportunities advertising.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 4 2012-07-01 2012-07-01 false Job opportunities advertising. 1604.5 Section 1604.5 Labor... BECAUSE OF SEX § 1604.5 Job opportunities advertising. It is a violation of title VII for a help-wanted... a bona fide occupational qualification for the particular job involved. The placement of...

  13. 29 CFR 1604.5 - Job opportunities advertising.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Job opportunities advertising. 1604.5 Section 1604.5 Labor... BECAUSE OF SEX § 1604.5 Job opportunities advertising. It is a violation of title VII for a help-wanted... a bona fide occupational qualification for the particular job involved. The placement of...

  14. 29 CFR 1604.5 - Job opportunities advertising.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 4 2013-07-01 2013-07-01 false Job opportunities advertising. 1604.5 Section 1604.5 Labor... BECAUSE OF SEX § 1604.5 Job opportunities advertising. It is a violation of title VII for a help-wanted... a bona fide occupational qualification for the particular job involved. The placement of...

  15. A Symposium on Employment Rights of the Handicapped.

    ERIC Educational Resources Information Center

    DePaul Law Review, 1978

    1978-01-01

    Employment rights of the handicapped are examined in this collection of symposium papers. Addressed are: procedural aspects of plaintiff litigation, job relatedness and bona fide occupational qualification doctrines, plaintiff's private right of action, arbitration, insurance, state fair employment legislation, and federal and constitutional…

  16. Guidelines on Discrimination Because of Sex.

    ERIC Educational Resources Information Center

    Equal Employment Opportunity Commission, Washington, DC.

    This brochure presents regulatory guidelines on sex discrimination with sections devoted to: general principles; sex as a bona fide occupational qualification; separate lines of progression and seniority systems; discrimination against married women; advertising job opportunities; employment agencies; pre-employment inquiries as to sex; the…

  17. Pime v. Loyola University of Chicago: The Seventh Circuit Extends the BFOQ Defense.

    ERIC Educational Resources Information Center

    Curry, Susan J.; And Others

    1988-01-01

    The significance of the court decision in Pime vs. Loyola University of Chicago, concerning the university's right to reserve tenure track positions for Jesuit faculty, is in the expansion of the defense relating to bona fide occupational qualifications. It opens other schools to similar litigation. (MSE)

  18. Age Discrimination in Employment Suits: A Practical Guide.

    ERIC Educational Resources Information Center

    McDonald, J. Michael

    1979-01-01

    Focuses on those elements of an age discrimination suit that have traditionally presented the most difficulty for attorneys--burden of proof, bona fide occupational qualifications, and procedure matters among them. Available from West Virginia Law Review, W.V.U. Law Center, Morgantown, West Virginia 26506; sc $4.00. (Author/IRT)

  19. Relating Age Change and Behavior to Job Requirements.

    ERIC Educational Resources Information Center

    Schaie, K. Warner

    The Age Discrimination in Employment Act has been amended to outlaw mandatory retirement at any age. However, the act permits employers to impose a specific retirement age if there is a bona fide occupational qualification (BFOQ) which cannot be met by all or most individuals. Imposition of BFOQ mandatory retirement ages by employers has led to…

  20. 15 CFR 40.2 - Qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... bona-fide citizen of a country with whom the United States has proper diplomatic arrangements for such training programs. (2) Able to speak, read, write, and understand the English language. (3) Sponsored...

  1. Peaceful Uses Bona Fides: Criteria for Evaluation and Case Studies

    SciTech Connect

    Ajemian, Chris K.; Hazel, Mike; Kessler, Carol E.; Mathews, Carrie E.; Morris, Fred A.; Seward, Amy M.; Peterson, Danielle J.; Smith, Brian W.

    2007-06-06

    This study applies a set of indicators to assess the peaceful nature of a state’s nuclear program. Evaluation of a country’s nuclear program relative to these indicators can help the international community to take appropriate actions to ensure that the growth of the global nuclear energy industry proceeds peacefully and to minimize nuclear proliferation risks.

  2. Differentiating Bona Fide Strategic Planning from Other Planning.

    ERIC Educational Resources Information Center

    Meredith, Mark; And Others

    The extent to which a college has been engaged in strategic planning was studied with a sample of 96 institutions which had been identified as using strategic planning in a 1985 study. Survey questions consisted of a mixture of: (1) activities proper and essential to strategic planning; and (2) approaches and views of strategic planning that have…

  3. 7 CFR 27.93 - Bona fide spot markets.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., East Texas and Oklahoma, West Texas, Desert Southwest and San Joaquin Valley. Such markets will... counties. San Joaquin Valley All California counties except those included in the Desert Southwest market. ..., Erath, Comanche, Mills, San Saba, Mason, Sutton, Edwards, Kinney, Maverick, Webb, Zapata, Star...

  4. 7 CFR 27.93 - Bona fide spot markets.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., East Texas and Oklahoma, West Texas, Desert Southwest and San Joaquin Valley. Such markets will... counties. San Joaquin Valley All California counties except those included in the Desert Southwest market. ..., Erath, Comanche, Mills, San Saba, Mason, Sutton, Edwards, Kinney, Maverick, Webb, Zapata, Star...

  5. 7 CFR 27.93 - Bona fide spot markets.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., East Texas and Oklahoma, West Texas, Desert Southwest and San Joaquin Valley. Such markets will... counties. San Joaquin Valley All California counties except those included in the Desert Southwest market. ..., Parker, Erath, Comanche, Mills, San Saba, Mason, Sutton, Edwards, Kinney, Maverick, Webb, Zapata,...

  6. 7 CFR 27.93 - Bona fide spot markets.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., East Texas and Oklahoma, West Texas, Desert Southwest and San Joaquin Valley. Such markets will... counties. San Joaquin Valley All California counties except those included in the Desert Southwest market. ..., Erath, Comanche, Mills, San Saba, Mason, Sutton, Edwards, Kinney, Maverick, Webb, Zapata, Star...

  7. New Zealand's Move to Graduate-Profile Framed Qualifications: Implications, Challenges and the Occupational Identity Solution

    ERIC Educational Resources Information Center

    Chan, Selena

    2016-01-01

    In 2008, the New Zealand Qualifications Authority (NZQA), responsible for the quality assurance of all qualifications, embarked on a review of all qualifications between Levels 1 and 6 on the 10-level National Qualifications Framework (NQF). The review process mandated the reviewed qualifications to be founded on outcome statements of graduate…

  8. Occupational and Qualification Structures in the Field of Environmental Protection in the Metal and Chemical Industries in Italy.

    ERIC Educational Resources Information Center

    Stanzani, Claudio

    This report provides an initial analysis of the occupational and qualification structures in the field of environmental protection in the Italian metal and chemical industries. The first two chapters review the legislative background, situation in industry, and provision of environmental education and training. The third chapter presents results…

  9. Occupational and Qualification Structures in the Field of Environmental Protection in the Metal and Chemical Industries in the United Kingdom.

    ERIC Educational Resources Information Center

    European Centre for the Development of Vocational Training, Berlin (Germany).

    A study analyzed the occupational structure and qualifications associated with the field of environmental protection in the metal and chemical industries in the United Kingdom. The analysis included nine case studies based on interviews with firms in the chemicals and metals sectors. Information was gathered within an analytical framework that…

  10. Occupational and Qualification Structures in the Field of Environmental Protection in the Metal and Chemical Industries--Study on the Federal Republic of Germany.

    ERIC Educational Resources Information Center

    Nitschke, Christoph; And Others

    A study focused on new occupational and qualification structures in the field of environmental protection in the metal and chemical industries in the Federal Republic of Germany. A total of 22 interviews were conducted with representatives of 11 firms. The public debate on occupational requirements in the field of environmental protection and on…

  11. How Closely Do Australian Training Package Qualifications Reflect the Skills in Occupations? An Empirical Investigation of Seven Qualifications

    ERIC Educational Resources Information Center

    Smith, Erica; Smith, Andy; Hampson, Ian; Junor, Anne

    2015-01-01

    This paper uses evidence from an Australian research project into under-recognized skills in occupations, gathered through industry-level interviews and company case studies, to examine VET curricula. The project, funded by the Australian Research Council, focused on skill in jobs traditionally regarded in Australia as unskilled. As part of the…

  12. Canadian Classification and Dictionary of Occupations 1971. Volume One, Classification and Definitions. Volume Two, Occupational Qualification Requirements.

    ERIC Educational Resources Information Center

    Department of Manpower and Immigration, Ottawa (Ontario). Program Development Service.

    The Canadian Classification and Dictionary of Occupations (CCDO) has been designed for use in manpower research and analysis, conducting surveys, census taking and compilation, planning of educational and training programs, counseling and placement services, rehabilitation, immigration and mobility of workers, and personnel and other operations in…

  13. The Recognition of Occupational Skills and Educational Qualifications within the EEC.

    ERIC Educational Resources Information Center

    Bertrand, Olivier

    1992-01-01

    A survey conducted in France, Germany, Italy, Spain, and the United Kingdom analyzed employment practices and viewpoints of the social partners regarding comparability of qualifications and geographical mobility. Carried out in late 1991 with a limited sampling of respondents (firms, employers' organizations, and unions), the survey focused…

  14. European Trends in the Development of Occupations and Qualifications. Findings of Research, Studies and Analyses for Policy and Practice. Volume II. CEDEFOP Reference Document.

    ERIC Educational Resources Information Center

    Sellin, Burkart, Ed.

    This document contains 23 papers on European trends in vocational education and training (VET) and the development of occupations and qualifications. The following papers are included: "Vocational Socialisation and Competence Development: The Historical Dimension" (Walter R. Heinz); "European Trends in the Development of Vocational Education and…

  15. Occupational Forecasts for 1998 for Ireland and Their Implications for Educational Qualifications.

    ERIC Educational Resources Information Center

    Canny, Angela; Hughes, Gerard

    The Census of Population provides data on the structure of employment by occupation and industry for Ireland that are supplemented by the Labor Force Survey (LFS), which collects information on employment by occupation and industry. Expected strong growth in the Irish economy from 1993-98 should lead to a significant increase in employment. This…

  16. Co-operation in Research on Trends in the Development of Occupations and Qualifications in the European Union. Report on the Current State, Results and Development of the CEDEFOP Ciretoq Network. Interim Report, CEDEFOP Panorama.

    ERIC Educational Resources Information Center

    Sellin, Burkart

    The European Centre for the Development of Vocational Training has developed a thematic network on the Circle for Research Cooperation on Trends in Occupations and Qualifications (Ciretoq) to follow up its preliminary work on trends in qualifications and certification. On the basis of available surveys and surveys evaluated by Ciretoq, the…

  17. 45 CFR 1606.11 - Qualifications on hearing procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... debarment decisions shall state the effective date of the debarment and the period of debarment, which shall... debarment was based; (3) Bona fide change in ownership or management of a recipient; (4) Elimination of... described in § 1606.8(c), to review the matter and make a written recommended decision on debarment. (2)...

  18. 7 CFR 27.96 - Quotations in bona fide spot markets.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Cotton Division will on each business day determine and quote by bale volume the prices or values of base... determined and quoted by bale volume in each such spot market for those qualities normally produced or traded... settlement of futures contracts, the Cotton Division will on each business day determine and quote by...

  19. 7 CFR 27.96 - Quotations in bona fide spot markets.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Cotton Division will on each business day determine and quote by bale volume the prices or values of base... determined and quoted by bale volume in each such spot market for those qualities normally produced or traded... settlement of futures contracts, the Cotton Division will on each business day determine and quote by...

  20. 17 CFR 151.5 - Bona fide hedging and other exemptions for Referenced Contracts.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... representation for a period of at least two years following the expiration of the swap. (j) Financial distress... persons under financial distress circumstances for a time certain from any of the requirements of this part. Financial distress circumstances are situations involving the potential default or bankruptcy...

  1. 17 CFR 151.5 - Bona fide hedging and other exemptions for Referenced Contracts.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... representation for a period of at least two years following the expiration of the swap. (j) Financial distress... persons under financial distress circumstances for a time certain from any of the requirements of this part. Financial distress circumstances are situations involving the potential default or bankruptcy...

  2. 17 CFR Appendix B to Part 151 - Examples of Bona Fide Hedging Transactions and Positions

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... TRADING COMMISSION POSITION LIMITS FOR FUTURES AND SWAPS Pt. 151, App. B Appendix B to Part 151—Examples... the last five trading days. 521 Put-call parity describes the mathematical relationship between price... will be processed into 5,000 ounces of silver. To finance the purchase, Silver Processor A borrows...

  3. 17 CFR Appendix B to Part 151 - Examples of Bona Fide Hedging Transactions and Positions

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... TRADING COMMISSION (CONTINUED) POSITION LIMITS FOR FUTURES AND SWAPS Pt. 151, App. B Appendix B to Part... the last five trading days. 521 Put-call parity describes the mathematical relationship between price... will be processed into 5,000 ounces of silver. To finance the purchase, Silver Processor A borrows...

  4. Variability in automatic activation as an unobtrusive measure of racial attitudes: a bona fide pipeline?

    PubMed

    Fazio, R H; Jackson, J R; Dunton, B C; Williams, C J

    1995-12-01

    The research examines an unobtrusive measure of racial attitudes based on the evaluations that are automatically activated from memory on the presentation of Black versus White faces. Study 1, which concerned the technique's validity, obtained different attitude estimates for Black and White participants and also revealed that the variability among White participants was predictive of other race-related judgments and behavior. Study 2 concerned the lack of correspondence between the unobtrusive estimates and Modern Racism Scale (MRS) scores. The reactivity of the MRS was demonstrated in Study 3. Study 4 observed an interaction between the unobtrusive estimates and an individual difference in motivation to control prejudiced reactions when predicting MRS scores. The theoretical implications of the findings for consideration of automatic and controlled components of racial prejudice are discussed, as is the status of the MRS. PMID:8531054

  5. 26 CFR 1.937-1 - Bona fide residency in a possession.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... of the Internal Revenue Code. Example 7. Closer connection to United States than to possession. Z, a... and venture capital business. Z's wife and two teenage children remain in State C to allow the children to complete high school. Z travels back to the United States regularly to see his wife...

  6. 26 CFR 1.937-1 - Bona fide residency in a possession.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... of the Internal Revenue Code. Example 7. Closer connection to United States than to possession. Z, a... and venture capital business. Z's wife and two teenage children remain in State C to allow the children to complete high school. Z travels back to the United States regularly to see his wife...

  7. 26 CFR 1.937-1 - Bona fide residency in a possession.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... of the Internal Revenue Code. Example 7. Closer connection to United States than to possession. Z, a... and venture capital business. Z's wife and two teenage children remain in State C to allow the children to complete high school. Z travels back to the United States regularly to see his wife...

  8. 26 CFR 1.937-1 - Bona fide residency in a possession.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... spouse from whom the individual is legally separated under a decree of divorce or separate maintenance... tourist season. For the remainder of each year, P lives with her husband and children in Possession...

  9. 17 CFR 151.5 - Bona fide hedging and other exemptions for Referenced Contracts.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... any physical-delivery Referenced Contract during the last five days of trading of the Core Referenced... such position is maintained in any physical-delivery Referenced Contract during the last five days of... position is maintained in any physical-delivery Referenced Contract during the last five days of trading...

  10. 7 CFR 27.96 - Quotations in bona fide spot markets.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... determined by the sale of spot cotton in such spot market. Quotations shall be determined and maintained in each designated spot market by the Cotton Division, Agricultural Marketing Service, USDA, as follows... determined and quoted by bale volume in each such spot market for those qualities normally produced or...

  11. 7 CFR 27.96 - Quotations in bona fide spot markets.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... determined by the sale of spot cotton in such spot market. Quotations shall be determined and maintained in each designated spot market by the Cotton Division, Agricultural Marketing Service, USDA, as follows... determined and quoted by bale volume in each such spot market for those qualities normally produced or...

  12. 7 CFR 27.96 - Quotations in bona fide spot markets.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... determined by the sale of spot cotton in such spot market. Quotations shall be determined and maintained in each designated spot market by the Cotton Division, Agricultural Marketing Service, USDA, as follows... determined and quoted by bale volume in each such spot market for those qualities normally produced or...

  13. 29 CFR 4.156 - Employees in bona fide executive, administrative, or professional capacity.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... set forth in 29 CFR part 541. Thus, such employees as laboratory technicians, draftsmen, and air..., administrative, or professional capacity as those terms are defined in 29 CFR part 541. Employees within...

  14. 29 CFR 4.156 - Employees in bona fide executive, administrative, or professional capacity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... set forth in 29 CFR part 541. Thus, such employees as laboratory technicians, draftsmen, and air..., administrative, or professional capacity as those terms are defined in 29 CFR part 541. Employees within...

  15. 29 CFR 4.156 - Employees in bona fide executive, administrative, or professional capacity.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... set forth in 29 CFR part 541. Thus, such employees as laboratory technicians, draftsmen, and air..., administrative, or professional capacity as those terms are defined in 29 CFR part 541. Employees within...

  16. 29 CFR 4.156 - Employees in bona fide executive, administrative, or professional capacity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... set forth in 29 CFR part 541. Thus, such employees as laboratory technicians, draftsmen, and air..., administrative, or professional capacity as those terms are defined in 29 CFR part 541. Employees within...

  17. Genome segment 5 of Antheraea mylitta cytoplasmic polyhedrosis virus encodes a bona fide guanylyltransferase

    PubMed Central

    2014-01-01

    Background Antheraea mylitta cytoplasmic polyhedrosis virus (AmCPV), a cypovirus of Reoviridae family, infects non mulberry Indian silk worm, Antheraea mylitta, and contains eleven segmented double stranded RNA in its genome (S1-S11). Some of its genome segments (S1-S3, and S6-S11) have been previously characterized but genome segment encoding the viral guanylyltransferase which helps in RNA capping has not been characterized. Results In this study genome segment 5 (S5) of AmCPV was converted to cDNA, cloned and sequenced. S5 consisted of 2180 nucleotides, with one long ORF of 1818 nucleotides and could encode a protein of 606 amino acids with molecular mass of ~65 kDa (p65). Bioinformatics analysis showed presence of KLRS and HxnH motifs as observed in some other reoviral guanylyltransferase and suggests that S5 may encodes viral guanylyltransferase. The ORF of S5 was expressed in E. coli as 65 kDa his tagged fusion protein, purified through Ni-NTA chromatography and polyclonal antibody was raised. Immunoblot analysis of virion particles with the purified antibody showed specific immunoreactive band and suggests p65 as a viral structural protein. Functional analysis showed that recombinant p65 possesses guanylyltransferase activity, and transfers GMP moiety to the 5' diphosphate (A/G) ended viral RNA after the formation of p65-GMP complex for capping. Kinetic analysis showed Km of this enzyme for GTP and RNA was 34.24 uM and 98.35 nM, respectively. Site directed mutagenesis at K21A in KLRS motif, and H93A or H105A in HxnH motif completely abolished the autoguanylylation activity and indicates importance of these residues at these sites. Thermodynamic analysis showed p65-GTP interaction was primarily driven by enthalpy (ΔH = -399.1 ± 4.1 kJ/mol) whereas the p65-RNA interaction by favorable entropy (0.043 ± 0.0049 kJ/ mol). Conclusion Viral capping enzymes play a critical role in the post transcriptional or post replication modification in case of RNA virus. Our results of cloning, sequencing and functional analysis of AmCPV S5 indicates that S5 encoded p65 through its guanylyltransferase activity can transfer guanine residue to the 5' end of viral RNA for capping. Further studies will help to understand complete capping process of cypoviral RNA during viral replication within the viral capsid. PMID:24649879

  18. 29 CFR 516.3 - Bona fide executive, administrative, and professional employees (including academic...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... employees (including academic administrative personnel and teachers in elementary or secondary schools), and... professional employees (including academic administrative personnel and teachers in elementary or secondary... employed in the capacity of academic administrative personnel or teachers in elementary or...

  19. A bona fide La protein is required for embryogenesis in Arabidopsis thaliana

    PubMed Central

    Fleurdépine, Sophie; Deragon, Jean-Marc; Devic, Martine; Guilleminot, Jocelyne; Bousquet-Antonelli, Cécile

    2007-01-01

    Searches in the Arabidopsis thaliana genome using the La motif as query revealed the presence of eight La or La-like proteins. Using structural and phylogenetic criteria, we identified two putative genuine La proteins (At32 and At79) and showed that both are expressed throughout plant development but at different levels and under different regulatory conditions. At32, but not At79, restores Saccharomyces cerevisiae La nuclear functions in non-coding RNAs biogenesis and is able to bind to plant 3′-UUU-OH RNAs. We conclude that these La nuclear functions are conserved in Arabidopsis and supported by At32, which we renamed as AtLa1. Consistently, AtLa1 is predominantly localized to the plant nucleoplasm and was also detected in the nucleolar cavity. The inactivation of AtLa1 in Arabidopsis leads to an embryonic-lethal phenotype with deficient embryos arrested at early globular stage of development. In addition, mutant embryonic cells display a nucleolar hypertrophy suggesting that AtLa1 is required for normal ribosome biogenesis. The identification of two distantly related proteins with all structural characteristics of genuine La proteins suggests that these factors evolved to a certain level of specialization in plants. This unprecedented situation provides a unique opportunity to dissect the very different aspects of this crucial cellular activity. PMID:17459889

  20. 29 CFR 516.3 - Bona fide executive, administrative, and professional employees (including academic...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... employees (including academic administrative personnel and teachers in elementary or secondary schools), and... professional employees (including academic administrative personnel and teachers in elementary or secondary... employed in the capacity of academic administrative personnel or teachers in elementary or...

  1. 29 CFR 516.3 - Bona fide executive, administrative, and professional employees (including academic...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... employees (including academic administrative personnel and teachers in elementary or secondary schools), and... professional employees (including academic administrative personnel and teachers in elementary or secondary... employed in the capacity of academic administrative personnel or teachers in elementary or...

  2. 26 CFR 1.937-1 - Bona fide residency in a possession.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... international waters. For this purpose, a vessel is considered to be predominantly used in local and international waters if, during the taxable year, the aggregate amount of time it is used in international... vacation to Europe and Asia. Thus, for taxable year 2006, W is not present in Possession P for at least...

  3. Handling context-sensitivity in protein structures using graph theory: bona fide prediction.

    PubMed

    Samudrala, R; Moult, J

    1997-01-01

    We constructed five comparative models in a blind manner for the second meeting on the Critical Assessment of protein Structure Prediction methods (CASP2). The method used is based on a novel graph-theoretic clique-finding approach, and attempts to address the problem of interconnected structural changes in the comparative modeling of protein structures. We discuss briefly how the method is used for protein structure prediction, and detail how it performs in the blind tests. We find that compared to CASP1, significant improvements in building insertions and deletions and sidechain conformations have been achieved. PMID:9485494

  4. Discriminating strength: a bona fide measure of non-classical correlations

    NASA Astrophysics Data System (ADS)

    Farace, A.; De Pasquale, A.; Rigovacca, L.; Giovannetti, V.

    2014-07-01

    A new measure of non-classical correlations is introduced and characterized. It tests the ability of using a state ρ of a composite system AB as a probe for a quantum illumination task (e.g. see Lloyd 2008 Science 321 1463), in which one is asked to remotely discriminate between the two following scenarios: (i) either nothing happens to the probe, or (ii) the subsystem A is transformed via a local unitary {{R}_{A}} whose properties are partially unspecified when producing ρ. This new measure can be seen as the discrete version of the recently introduced interferometric power measure (Girolami et al 2013 e-print arXiv:1309.1472) and, at least for the case in which A is a qubit, it is shown to coincide (up to an irrelevant scaling factor) with the local quantum uncertainty measure of Girolami, Tufarelli and Adesso (2013 Phys. Rev. Lett. 110 240402). Analytical expressions are derived which allow us to formally prove that, within the set of separable configurations, the maximum value of our non-classicality measure is achieved over the set of quantum-classical states (i.e. states ρ which admit a statistical unravelling where each element of the associated ensemble is distinguishable via local measures on B).

  5. Human Services: A Bona Fide Profession in the 21st Century.

    ERIC Educational Resources Information Center

    Diambra, Joel F.

    2000-01-01

    Discusses interviews with David Maloney, Franklin Rother, and Lynn McKinney concerning the status of human services as an established profession. Summarizes that human services has come a long way in establishing itself as a unique and worthwhile career and that the job market for human service workers well trained and skilled in direct service…

  6. 29 CFR 516.3 - Bona fide executive, administrative, and professional employees (including academic...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... employees (including academic administrative personnel and teachers in elementary or secondary schools), and... professional employees (including academic administrative personnel and teachers in elementary or secondary... employed in the capacity of academic administrative personnel or teachers in elementary or...

  7. 29 CFR 516.3 - Bona fide executive, administrative, and professional employees (including academic...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... employees (including academic administrative personnel and teachers in elementary or secondary schools), and... professional employees (including academic administrative personnel and teachers in elementary or secondary... employed in the capacity of academic administrative personnel or teachers in elementary or...

  8. Mobility in Europe (EU and EEA) with Particular Reference to Health Care Occupations and Recognition of the Relevant Vocational Qualifications.

    ERIC Educational Resources Information Center

    Sellin, Burkart

    2002-01-01

    Analysis of recent trends in European mobility and migration and transnational recognition of qualifications in the health sector indicates no major increase in mobility in the European Union; more complex and fluid migration patterns; and increased competition for highly skilled workers, especially in health care. Fundamental barriers to mobility…

  9. 78 FR 20642 - Notice of Proposed CERCLA Agreement and Order on Consent for Removal Action by Bona Fide...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-05

    ... Prospective Purchaser; All Metals Processing Company Site, San Fernando Valley Area 2 Superfund Site, Glendale... concerning a removal action to carried out at the All Metal Processing Company Site, part of the San...

  10. Dictyostelium discoideum CenB Is a Bona Fide Centrin Essential for Nuclear Architecture and Centrosome Stability ▿

    PubMed Central

    Mana-Capelli, Sebastian; Gräf, Ralph; Larochelle, Denis A.

    2009-01-01

    Centrins are a family of proteins within the calcium-binding EF-hand superfamily. In addition to their archetypical role at the microtubule organizing center (MTOC), centrins have acquired multiple functionalities throughout the course of evolution. For example, centrins have been linked to different nuclear activities, including mRNA export and DNA repair. Dictyostelium discoideum centrin B is a divergent member of the centrin family. At the amino acid level, DdCenB shows 51% identity with its closest relative and only paralog, DdCenA. Phylogenetic analysis revealed that DdCenB and DdCenA form a well-supported monophyletic and divergent group within the centrin family of proteins. Interestingly, fluorescently tagged versions of DdCenB were not found at the centrosome (in whole cells or in isolated centrosomes). Instead, DdCenB localized to the nuclei of interphase cells. This localization disappeared as the cells entered mitosis, although Dictyostelium cells undergo a closed mitosis in which the nuclear envelope (NE) does not break down. DdCenB knockout cells exhibited aberrant nuclear architecture, characterized by enlarged and deformed nuclei and loss of proper centrosome-nucleus anchoring (observed as NE protrusions). At the centrosome, loss of DdCenB resulted in defects in the organization and morphology of the MTOC and supernumerary centrosomes and centrosome-related bodies. The multiple defects that the loss of DdCenB generated at the centrosome can be explained by its atypical division cycle, transitioning into the NE as it divides at mitosis. On the basis of these findings, we propose that DdCenB is required at interphase to maintain proper nuclear architecture, and before delocalizing from the nucleus, DdCenB is part of the centrosome duplication machinery. PMID:19465563